HEADER VIRAL PROTEIN/IMMUNE SYSTEM 03-AUG-22 8DY6 TITLE VACCINE ELICITED ANTIBODY MU89+S27Y BOUND TO TITLE 2 CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 ENV TRIMER COMPND MOL_ID: 1; COMPND 2 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; COMPND 3 CHAIN: A, B, E, F, I, J; COMPND 4 SYNONYM: ENV POLYPROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 OTHER_DETAILS: CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: MU89+S27Y HEAVY CHAIN; COMPND 9 CHAIN: C, G, K; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: MU89+S27Y LIGHT CHAIN; COMPND 13 CHAIN: D, H, L; COMPND 14 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 GENE: ENV; SOURCE 5 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 9 ORGANISM_TAXID: 10090; SOURCE 10 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 14 ORGANISM_TAXID: 10090; SOURCE 15 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 40674 KEYWDS HIV-1 ENVELOPE, VACCINE-INDUCED ANTIBODY, BROADLY NEUTRALIZING KEYWDS 2 ANTIBODY, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR V.STALLS,P.ACHARYA JRNL AUTH K.WIEHE,K.O.SAUNDERS,V.STALLS,D.CAIN,S.VENKATAYOGI, JRNL AUTH 2 J.S.MARTIN BEEM,M.BERRY,T.EVANGELOUS,R.HENDERSON,B.HORA, JRNL AUTH 3 S.XIA,C.JIANG,A.NEWMAN,C.BOWMAN,X.LU,M.E.BRYAN,J.BAL, JRNL AUTH 4 A.SANZONE,H.CHEN,A.EATON,M.A.TOMAI,C.B.FOX,Y.TAM,C.BARBOSA, JRNL AUTH 5 M.BONSIGNORI,H.MURAMATSU,S.M.ALAM,D.MONTEFIORI,W.B.WILLIAMS, JRNL AUTH 6 N.PARDI,M.TIAN,D.WEISMAN,F.W.ALT,P.ACHARYA,B.F.HAYNES JRNL TITL MUTATION-GUIDED VACCINE DESIGN: A STRATEGY FOR DEVELOPING JRNL TITL 2 BOOSTING IMMUNOGENS FOR HIV BROADLY NEUTRALIZING ANTIBODY JRNL TITL 3 INDUCTION JRNL REF BIORXIV 2022 JRNL REFN ISSN 2692-8205 JRNL DOI 10.1101/2022.11.11.516143V1 REMARK 2 REMARK 2 RESOLUTION. 4.32 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : LATITUDE, CRYOSPARC, UCSF CHIMERAX, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, PHENIX, COOT, ISOLDE REMARK 3 RECONSTRUCTION SCHEMA : FOURIER SPACE REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 6UM6 REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.320 REMARK 3 NUMBER OF PARTICLES : 65441 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8DY6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB. REMARK 100 THE DEPOSITION ID IS D_1000267359. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : V3-GLYCAN VACCINE INDUCED REMARK 245 ANTIBODY MU89+S27Y IN COMPLEX WITH CH848.D949.10.17_N133D_ REMARK 245 N138T.DS.SOSIP.664 HIV ENV TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.50 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 1801 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 59.30 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i, j, k, l, REMARK 350 AND CHAINS: m, n, o, p, q, r, s, t, u, v, REMARK 350 AND CHAINS: w, x, y REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 9 REMARK 465 GLY A 10 REMARK 465 SER A 11 REMARK 465 LEU A 12 REMARK 465 GLN A 13 REMARK 465 PRO A 14 REMARK 465 LEU A 15 REMARK 465 ALA A 16 REMARK 465 THR A 17 REMARK 465 LEU A 18 REMARK 465 TYR A 19 REMARK 465 LEU A 20 REMARK 465 LEU A 21 REMARK 465 GLY A 22 REMARK 465 MET A 23 REMARK 465 LEU A 24 REMARK 465 VAL A 25 REMARK 465 ALA A 26 REMARK 465 SER A 27 REMARK 465 VAL A 28 REMARK 465 LEU A 29 REMARK 465 ALA A 30 REMARK 465 ALA A 31 REMARK 465 GLU A 32 REMARK 465 VAL A 506 REMARK 465 GLY A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 ALA A 514 REMARK 465 VAL A 515 REMARK 465 GLY A 516 REMARK 465 ILE A 517 REMARK 465 GLY A 518 REMARK 465 ALA A 519 REMARK 465 VAL A 520 REMARK 465 PHE A 521 REMARK 465 LEU A 522 REMARK 465 GLY A 523 REMARK 465 PHE A 524 REMARK 465 LEU A 525 REMARK 465 GLY A 526 REMARK 465 ALA A 527 REMARK 465 ALA A 528 REMARK 465 GLY A 529 REMARK 465 SER A 530 REMARK 465 THR A 531 REMARK 465 MET A 532 REMARK 465 GLY A 533 REMARK 465 ALA A 534 REMARK 465 ALA A 535 REMARK 465 SER A 536 REMARK 465 MET A 537 REMARK 465 THR A 538 REMARK 465 LEU A 539 REMARK 465 THR A 540 REMARK 465 VAL A 541 REMARK 465 GLN A 542 REMARK 465 ALA A 543 REMARK 465 ARG A 544 REMARK 465 ASN A 545 REMARK 465 LEU A 546 REMARK 465 LEU A 547 REMARK 465 SER A 548 REMARK 465 GLY A 549 REMARK 465 ILE A 550 REMARK 465 VAL A 551 REMARK 465 GLN A 552 REMARK 465 GLN A 553 REMARK 465 GLN A 554 REMARK 465 SER A 555 REMARK 465 ASN A 556 REMARK 465 LEU A 557 REMARK 465 LEU A 558 REMARK 465 ARG A 559 REMARK 465 ALA A 560 REMARK 465 PRO A 561 REMARK 465 GLU A 562 REMARK 465 ALA A 563 REMARK 465 GLN A 564 REMARK 465 GLN A 565 REMARK 465 HIS A 566 REMARK 465 LEU A 567 REMARK 465 LEU A 568 REMARK 465 LYS A 569 REMARK 465 LEU A 570 REMARK 465 THR A 571 REMARK 465 VAL A 572 REMARK 465 TRP A 573 REMARK 465 GLY A 574 REMARK 465 ILE A 575 REMARK 465 LYS A 576 REMARK 465 GLN A 577 REMARK 465 LEU A 578 REMARK 465 GLN A 579 REMARK 465 ALA A 580 REMARK 465 ARG A 581 REMARK 465 VAL A 582 REMARK 465 LEU A 583 REMARK 465 ALA A 584 REMARK 465 VAL A 585 REMARK 465 GLU A 586 REMARK 465 ARG A 587 REMARK 465 TYR A 588 REMARK 465 LEU A 589 REMARK 465 ARG A 590 REMARK 465 ASP A 591 REMARK 465 GLN A 592 REMARK 465 GLN A 593 REMARK 465 LEU A 594 REMARK 465 LEU A 595 REMARK 465 GLY A 596 REMARK 465 ILE A 597 REMARK 465 TRP A 598 REMARK 465 GLY A 599 REMARK 465 CYS A 600 REMARK 465 SER A 601 REMARK 465 GLY A 602 REMARK 465 LYS A 603 REMARK 465 LEU A 604 REMARK 465 ILE A 605 REMARK 465 CYS A 606 REMARK 465 CYS A 607 REMARK 465 THR A 608 REMARK 465 ASN A 609 REMARK 465 VAL A 610 REMARK 465 PRO A 611 REMARK 465 TRP A 612 REMARK 465 ASN A 613 REMARK 465 SER A 614 REMARK 465 SER A 615 REMARK 465 TRP A 616 REMARK 465 SER A 617 REMARK 465 ASN A 618 REMARK 465 ARG A 619 REMARK 465 ASN A 620 REMARK 465 LEU A 621 REMARK 465 SER A 622 REMARK 465 GLU A 623 REMARK 465 ILE A 624 REMARK 465 TRP A 625 REMARK 465 ASP A 626 REMARK 465 ASN A 627 REMARK 465 MET A 628 REMARK 465 THR A 629 REMARK 465 TRP A 630 REMARK 465 LEU A 631 REMARK 465 GLN A 632 REMARK 465 TRP A 633 REMARK 465 ASP A 634 REMARK 465 LYS A 635 REMARK 465 GLU A 636 REMARK 465 ILE A 637 REMARK 465 SER A 638 REMARK 465 ASN A 639 REMARK 465 TYR A 640 REMARK 465 THR A 641 REMARK 465 GLN A 642 REMARK 465 ILE A 643 REMARK 465 ILE A 644 REMARK 465 TYR A 645 REMARK 465 GLY A 646 REMARK 465 LEU A 647 REMARK 465 LEU A 648 REMARK 465 GLU A 649 REMARK 465 GLU A 650 REMARK 465 SER A 651 REMARK 465 GLN A 652 REMARK 465 ASN A 653 REMARK 465 GLN A 654 REMARK 465 GLN A 655 REMARK 465 GLU A 656 REMARK 465 LYS A 657 REMARK 465 ASN A 658 REMARK 465 GLU A 659 REMARK 465 GLN A 660 REMARK 465 ASP A 661 REMARK 465 LEU A 662 REMARK 465 LEU A 663 REMARK 465 ALA A 664 REMARK 465 LEU A 665 REMARK 465 ASP A 666 REMARK 465 MET B 19 REMARK 465 GLY B 20 REMARK 465 SER B 21 REMARK 465 LEU B 22 REMARK 465 GLN B 23 REMARK 465 PRO B 24 REMARK 465 LEU B 25 REMARK 465 ALA B 26 REMARK 465 THR B 27 REMARK 465 LEU B 28 REMARK 465 TYR B 29 REMARK 465 LEU B 30 REMARK 465 LEU B 31 REMARK 465 GLY B 32 REMARK 465 MET B 33 REMARK 465 LEU B 34 REMARK 465 VAL B 35 REMARK 465 ALA B 36 REMARK 465 SER B 37 REMARK 465 VAL B 38 REMARK 465 LEU B 39 REMARK 465 ALA B 40 REMARK 465 ALA B 41 REMARK 465 GLU B 42 REMARK 465 ASN B 43 REMARK 465 LEU B 44 REMARK 465 TRP B 45 REMARK 465 VAL B 46 REMARK 465 THR B 47 REMARK 465 VAL B 48 REMARK 465 TYR B 49 REMARK 465 TYR B 50 REMARK 465 GLY B 51 REMARK 465 VAL B 52 REMARK 465 PRO B 53 REMARK 465 VAL B 54 REMARK 465 TRP B 55 REMARK 465 LYS B 56 REMARK 465 GLU B 57 REMARK 465 ALA B 58 REMARK 465 LYS B 59 REMARK 465 THR B 60 REMARK 465 THR B 61 REMARK 465 LEU B 62 REMARK 465 PHE B 63 REMARK 465 CYS B 64 REMARK 465 ALA B 65 REMARK 465 SER B 66 REMARK 465 ASP B 67 REMARK 465 ALA B 68 REMARK 465 ARG B 69 REMARK 465 ALA B 70 REMARK 465 TYR B 71 REMARK 465 GLU B 72 REMARK 465 LYS B 73 REMARK 465 GLU B 74 REMARK 465 VAL B 75 REMARK 465 HIS B 76 REMARK 465 ASN B 77 REMARK 465 VAL B 78 REMARK 465 TRP B 79 REMARK 465 ALA B 80 REMARK 465 THR B 81 REMARK 465 HIS B 82 REMARK 465 ALA B 83 REMARK 465 CYS B 84 REMARK 465 VAL B 85 REMARK 465 PRO B 86 REMARK 465 THR B 87 REMARK 465 ASP B 88 REMARK 465 PRO B 89 REMARK 465 SER B 90 REMARK 465 PRO B 91 REMARK 465 GLN B 92 REMARK 465 GLU B 93 REMARK 465 LEU B 94 REMARK 465 VAL B 95 REMARK 465 LEU B 96 REMARK 465 GLY B 97 REMARK 465 ASN B 98 REMARK 465 VAL B 99 REMARK 465 THR B 100 REMARK 465 GLU B 101 REMARK 465 ASN B 102 REMARK 465 PHE B 103 REMARK 465 ASN B 104 REMARK 465 MET B 105 REMARK 465 TRP B 106 REMARK 465 LYS B 107 REMARK 465 ASN B 108 REMARK 465 ASP B 109 REMARK 465 MET B 110 REMARK 465 VAL B 111 REMARK 465 ASP B 112 REMARK 465 GLN B 113 REMARK 465 MET B 114 REMARK 465 HIS B 115 REMARK 465 GLU B 116 REMARK 465 ASP B 117 REMARK 465 ILE B 118 REMARK 465 ILE B 119 REMARK 465 SER B 120 REMARK 465 LEU B 121 REMARK 465 TRP B 122 REMARK 465 ASP B 123 REMARK 465 GLN B 124 REMARK 465 SER B 125 REMARK 465 LEU B 126 REMARK 465 LYS B 127 REMARK 465 PRO B 128 REMARK 465 CYS B 129 REMARK 465 VAL B 130 REMARK 465 LYS B 131 REMARK 465 LEU B 132 REMARK 465 THR B 133 REMARK 465 PRO B 134 REMARK 465 LEU B 135 REMARK 465 CYS B 136 REMARK 465 VAL B 137 REMARK 465 THR B 138 REMARK 465 LEU B 139 REMARK 465 ILE B 140 REMARK 465 CYS B 141 REMARK 465 SER B 142 REMARK 465 ASP B 143 REMARK 465 ALA B 144 REMARK 465 THR B 145 REMARK 465 VAL B 146 REMARK 465 LYS B 147 REMARK 465 THR B 148 REMARK 465 GLY B 149 REMARK 465 THR B 150 REMARK 465 VAL B 151 REMARK 465 GLU B 152 REMARK 465 GLU B 153 REMARK 465 MET B 154 REMARK 465 LYS B 155 REMARK 465 ASN B 156 REMARK 465 CYS B 157 REMARK 465 SER B 158 REMARK 465 PHE B 159 REMARK 465 ASN B 160 REMARK 465 THR B 161 REMARK 465 THR B 162 REMARK 465 THR B 163 REMARK 465 GLU B 164 REMARK 465 ILE B 165 REMARK 465 ARG B 166 REMARK 465 ASP B 167 REMARK 465 LYS B 168 REMARK 465 GLU B 169 REMARK 465 LYS B 170 REMARK 465 LYS B 171 REMARK 465 GLU B 172 REMARK 465 TYR B 173 REMARK 465 ALA B 174 REMARK 465 LEU B 175 REMARK 465 PHE B 176 REMARK 465 TYR B 177 REMARK 465 LYS B 178 REMARK 465 PRO B 179 REMARK 465 ASP B 180 REMARK 465 ILE B 181 REMARK 465 VAL B 182 REMARK 465 PRO B 183 REMARK 465 LEU B 184 REMARK 465 SER B 185 REMARK 465 GLU B 186 REMARK 465 THR B 187 REMARK 465 ASN B 188 REMARK 465 ASN B 189 REMARK 465 THR B 190 REMARK 465 SER B 191 REMARK 465 GLU B 192 REMARK 465 TYR B 193 REMARK 465 ARG B 194 REMARK 465 LEU B 195 REMARK 465 ILE B 196 REMARK 465 ASN B 197 REMARK 465 CYS B 198 REMARK 465 ASN B 199 REMARK 465 THR B 200 REMARK 465 SER B 201 REMARK 465 ALA B 202 REMARK 465 CYS B 203 REMARK 465 THR B 204 REMARK 465 GLN B 205 REMARK 465 ALA B 206 REMARK 465 CYS B 207 REMARK 465 PRO B 208 REMARK 465 LYS B 209 REMARK 465 VAL B 210 REMARK 465 THR B 211 REMARK 465 PHE B 212 REMARK 465 GLU B 213 REMARK 465 PRO B 214 REMARK 465 ILE B 215 REMARK 465 PRO B 216 REMARK 465 ILE B 217 REMARK 465 HIS B 218 REMARK 465 TYR B 219 REMARK 465 CYS B 220 REMARK 465 ALA B 221 REMARK 465 PRO B 222 REMARK 465 ALA B 223 REMARK 465 GLY B 224 REMARK 465 TYR B 225 REMARK 465 ALA B 226 REMARK 465 ILE B 227 REMARK 465 LEU B 228 REMARK 465 LYS B 229 REMARK 465 CYS B 230 REMARK 465 ASN B 231 REMARK 465 ASP B 232 REMARK 465 GLU B 233 REMARK 465 THR B 234 REMARK 465 PHE B 235 REMARK 465 ASN B 236 REMARK 465 GLY B 237 REMARK 465 THR B 238 REMARK 465 GLY B 239 REMARK 465 PRO B 240 REMARK 465 CYS B 241 REMARK 465 SER B 242 REMARK 465 ASN B 243 REMARK 465 VAL B 244 REMARK 465 SER B 245 REMARK 465 THR B 246 REMARK 465 VAL B 247 REMARK 465 GLN B 248 REMARK 465 CYS B 249 REMARK 465 THR B 250 REMARK 465 HIS B 251 REMARK 465 GLY B 252 REMARK 465 ILE B 253 REMARK 465 ARG B 254 REMARK 465 PRO B 255 REMARK 465 VAL B 256 REMARK 465 VAL B 257 REMARK 465 SER B 258 REMARK 465 THR B 259 REMARK 465 GLN B 260 REMARK 465 LEU B 261 REMARK 465 LEU B 262 REMARK 465 LEU B 263 REMARK 465 ASN B 264 REMARK 465 GLY B 265 REMARK 465 SER B 266 REMARK 465 LEU B 267 REMARK 465 ALA B 268 REMARK 465 GLU B 269 REMARK 465 LYS B 270 REMARK 465 GLU B 271 REMARK 465 ILE B 272 REMARK 465 VAL B 273 REMARK 465 ILE B 274 REMARK 465 ARG B 275 REMARK 465 SER B 276 REMARK 465 GLU B 277 REMARK 465 ASN B 278 REMARK 465 LEU B 279 REMARK 465 THR B 280 REMARK 465 ASN B 281 REMARK 465 ASN B 282 REMARK 465 ALA B 283 REMARK 465 LYS B 284 REMARK 465 ILE B 285 REMARK 465 ILE B 286 REMARK 465 ILE B 287 REMARK 465 VAL B 288 REMARK 465 HIS B 289 REMARK 465 LEU B 290 REMARK 465 HIS B 291 REMARK 465 THR B 292 REMARK 465 PRO B 293 REMARK 465 VAL B 294 REMARK 465 GLU B 295 REMARK 465 ILE B 296 REMARK 465 VAL B 297 REMARK 465 CYS B 298 REMARK 465 THR B 299 REMARK 465 ARG B 300 REMARK 465 PRO B 301 REMARK 465 ASN B 302 REMARK 465 ASN B 303 REMARK 465 ASN B 304 REMARK 465 THR B 305 REMARK 465 ARG B 306 REMARK 465 LYS B 307 REMARK 465 SER B 308 REMARK 465 VAL B 309 REMARK 465 ARG B 310 REMARK 465 ILE B 311 REMARK 465 GLY B 312 REMARK 465 PRO B 313 REMARK 465 GLY B 314 REMARK 465 GLN B 315 REMARK 465 THR B 316 REMARK 465 PHE B 317 REMARK 465 TYR B 318 REMARK 465 ALA B 319 REMARK 465 THR B 320 REMARK 465 GLY B 321 REMARK 465 ASP B 322 REMARK 465 ILE B 323 REMARK 465 ILE B 324 REMARK 465 GLY B 325 REMARK 465 ASP B 326 REMARK 465 ILE B 327 REMARK 465 LYS B 328 REMARK 465 GLN B 329 REMARK 465 ALA B 330 REMARK 465 HIS B 331 REMARK 465 CYS B 332 REMARK 465 ASN B 333 REMARK 465 ILE B 334 REMARK 465 SER B 335 REMARK 465 GLU B 336 REMARK 465 GLU B 337 REMARK 465 LYS B 338 REMARK 465 TRP B 339 REMARK 465 ASN B 340 REMARK 465 ASP B 341 REMARK 465 THR B 342 REMARK 465 LEU B 343 REMARK 465 GLN B 344 REMARK 465 LYS B 345 REMARK 465 VAL B 346 REMARK 465 GLY B 347 REMARK 465 ILE B 348 REMARK 465 GLU B 349 REMARK 465 LEU B 350 REMARK 465 GLN B 351 REMARK 465 LYS B 352 REMARK 465 HIS B 353 REMARK 465 PHE B 354 REMARK 465 PRO B 355 REMARK 465 ASN B 356 REMARK 465 LYS B 357 REMARK 465 THR B 358 REMARK 465 ILE B 359 REMARK 465 LYS B 360 REMARK 465 TYR B 361 REMARK 465 ASN B 362 REMARK 465 GLN B 363 REMARK 465 SER B 364 REMARK 465 ALA B 365 REMARK 465 GLY B 366 REMARK 465 GLY B 367 REMARK 465 ASP B 368 REMARK 465 MET B 369 REMARK 465 GLU B 370 REMARK 465 ILE B 371 REMARK 465 THR B 372 REMARK 465 THR B 373 REMARK 465 HIS B 374 REMARK 465 SER B 375 REMARK 465 PHE B 376 REMARK 465 ASN B 377 REMARK 465 CYS B 378 REMARK 465 GLY B 379 REMARK 465 GLY B 380 REMARK 465 GLU B 381 REMARK 465 PHE B 382 REMARK 465 PHE B 383 REMARK 465 TYR B 384 REMARK 465 CYS B 385 REMARK 465 ASN B 386 REMARK 465 THR B 387 REMARK 465 SER B 388 REMARK 465 ASN B 389 REMARK 465 LEU B 390 REMARK 465 PHE B 391 REMARK 465 ASN B 392 REMARK 465 GLY B 393 REMARK 465 THR B 394 REMARK 465 TYR B 395 REMARK 465 ASN B 396 REMARK 465 GLY B 397 REMARK 465 THR B 398 REMARK 465 TYR B 399 REMARK 465 ILE B 400 REMARK 465 SER B 401 REMARK 465 THR B 402 REMARK 465 ASN B 403 REMARK 465 SER B 404 REMARK 465 SER B 405 REMARK 465 ALA B 406 REMARK 465 ASN B 407 REMARK 465 SER B 408 REMARK 465 THR B 409 REMARK 465 SER B 410 REMARK 465 THR B 411 REMARK 465 ILE B 412 REMARK 465 THR B 413 REMARK 465 LEU B 414 REMARK 465 GLN B 415 REMARK 465 CYS B 416 REMARK 465 ARG B 417 REMARK 465 ILE B 418 REMARK 465 LYS B 419 REMARK 465 GLN B 420 REMARK 465 ILE B 421 REMARK 465 ILE B 422 REMARK 465 ASN B 423 REMARK 465 MET B 424 REMARK 465 TRP B 425 REMARK 465 GLN B 426 REMARK 465 GLY B 427 REMARK 465 VAL B 428 REMARK 465 GLY B 429 REMARK 465 ARG B 430 REMARK 465 CYS B 431 REMARK 465 MET B 432 REMARK 465 TYR B 433 REMARK 465 ALA B 434 REMARK 465 PRO B 435 REMARK 465 PRO B 436 REMARK 465 ILE B 437 REMARK 465 ALA B 438 REMARK 465 GLY B 439 REMARK 465 ASN B 440 REMARK 465 ILE B 441 REMARK 465 THR B 442 REMARK 465 CYS B 443 REMARK 465 ARG B 444 REMARK 465 SER B 445 REMARK 465 ASN B 446 REMARK 465 ILE B 447 REMARK 465 THR B 448 REMARK 465 GLY B 449 REMARK 465 LEU B 450 REMARK 465 LEU B 451 REMARK 465 LEU B 452 REMARK 465 THR B 453 REMARK 465 ARG B 454 REMARK 465 ASP B 455 REMARK 465 GLY B 456 REMARK 465 GLY B 457 REMARK 465 THR B 458 REMARK 465 ASN B 459 REMARK 465 SER B 460 REMARK 465 ASN B 461 REMARK 465 GLU B 462 REMARK 465 THR B 463 REMARK 465 GLU B 464 REMARK 465 THR B 465 REMARK 465 PHE B 466 REMARK 465 ARG B 467 REMARK 465 PRO B 468 REMARK 465 ALA B 469 REMARK 465 GLY B 470 REMARK 465 GLY B 471 REMARK 465 ASP B 472 REMARK 465 MET B 473 REMARK 465 ARG B 474 REMARK 465 ASP B 475 REMARK 465 ASN B 476 REMARK 465 TRP B 477 REMARK 465 ARG B 478 REMARK 465 SER B 479 REMARK 465 GLU B 480 REMARK 465 LEU B 481 REMARK 465 TYR B 482 REMARK 465 LYS B 483 REMARK 465 TYR B 484 REMARK 465 LYS B 485 REMARK 465 VAL B 486 REMARK 465 VAL B 487 REMARK 465 LYS B 488 REMARK 465 ILE B 489 REMARK 465 GLU B 490 REMARK 465 PRO B 491 REMARK 465 LEU B 492 REMARK 465 GLY B 493 REMARK 465 VAL B 494 REMARK 465 ALA B 495 REMARK 465 PRO B 496 REMARK 465 THR B 497 REMARK 465 ARG B 498 REMARK 465 CYS B 499 REMARK 465 LYS B 500 REMARK 465 ARG B 501 REMARK 465 ARG B 502 REMARK 465 VAL B 503 REMARK 465 VAL B 504 REMARK 465 GLY B 505 REMARK 465 ARG B 506 REMARK 465 ARG B 507 REMARK 465 ARG B 508 REMARK 465 ARG B 509 REMARK 465 ARG B 510 REMARK 465 ARG B 511 REMARK 465 ALA B 512 REMARK 465 VAL B 513 REMARK 465 GLY B 514 REMARK 465 ILE B 515 REMARK 465 GLY B 516 REMARK 465 ALA B 517 REMARK 465 VAL B 518 REMARK 465 PHE B 519 REMARK 465 LEU B 520 REMARK 465 GLY B 521 REMARK 465 ILE B 548 REMARK 465 VAL B 549 REMARK 465 GLN B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 SER B 553 REMARK 465 ASN B 554 REMARK 465 LEU B 555 REMARK 465 LEU B 556 REMARK 465 ARG B 557 REMARK 465 ALA B 558 REMARK 465 PRO B 559 REMARK 465 GLU B 560 REMARK 465 ALA B 561 REMARK 465 GLN B 562 REMARK 465 GLN B 563 REMARK 465 HIS B 564 REMARK 465 LEU B 565 REMARK 465 LEU B 566 REMARK 465 LYS B 567 REMARK 465 LEU B 568 REMARK 465 MET C -18 REMARK 465 GLY C -17 REMARK 465 TRP C -16 REMARK 465 SER C -15 REMARK 465 CYS C -14 REMARK 465 ILE C -13 REMARK 465 ILE C -12 REMARK 465 LEU C -11 REMARK 465 PHE C -10 REMARK 465 LEU C -9 REMARK 465 VAL C -8 REMARK 465 ALA C -7 REMARK 465 THR C -6 REMARK 465 ALA C -5 REMARK 465 THR C -4 REMARK 465 GLY C -3 REMARK 465 VAL C -2 REMARK 465 HIS C -1 REMARK 465 SER C 0 REMARK 465 GLN D 1 REMARK 465 SER D 2 REMARK 465 ALA D 3 REMARK 465 LEU D 4 REMARK 465 MET E 9 REMARK 465 GLY E 10 REMARK 465 SER E 11 REMARK 465 LEU E 12 REMARK 465 GLN E 13 REMARK 465 PRO E 14 REMARK 465 LEU E 15 REMARK 465 ALA E 16 REMARK 465 THR E 17 REMARK 465 LEU E 18 REMARK 465 TYR E 19 REMARK 465 LEU E 20 REMARK 465 LEU E 21 REMARK 465 GLY E 22 REMARK 465 MET E 23 REMARK 465 LEU E 24 REMARK 465 VAL E 25 REMARK 465 ALA E 26 REMARK 465 SER E 27 REMARK 465 VAL E 28 REMARK 465 LEU E 29 REMARK 465 ALA E 30 REMARK 465 ALA E 31 REMARK 465 GLU E 32 REMARK 465 VAL E 506 REMARK 465 GLY E 507 REMARK 465 ARG E 508 REMARK 465 ARG E 509 REMARK 465 ARG E 510 REMARK 465 ARG E 511 REMARK 465 ARG E 512 REMARK 465 ARG E 513 REMARK 465 ALA E 514 REMARK 465 VAL E 515 REMARK 465 GLY E 516 REMARK 465 ILE E 517 REMARK 465 GLY E 518 REMARK 465 ALA E 519 REMARK 465 VAL E 520 REMARK 465 PHE E 521 REMARK 465 LEU E 522 REMARK 465 GLY E 523 REMARK 465 PHE E 524 REMARK 465 LEU E 525 REMARK 465 GLY E 526 REMARK 465 ALA E 527 REMARK 465 ALA E 528 REMARK 465 GLY E 529 REMARK 465 SER E 530 REMARK 465 THR E 531 REMARK 465 MET E 532 REMARK 465 GLY E 533 REMARK 465 ALA E 534 REMARK 465 ALA E 535 REMARK 465 SER E 536 REMARK 465 MET E 537 REMARK 465 THR E 538 REMARK 465 LEU E 539 REMARK 465 THR E 540 REMARK 465 VAL E 541 REMARK 465 GLN E 542 REMARK 465 ALA E 543 REMARK 465 ARG E 544 REMARK 465 ASN E 545 REMARK 465 LEU E 546 REMARK 465 LEU E 547 REMARK 465 SER E 548 REMARK 465 GLY E 549 REMARK 465 ILE E 550 REMARK 465 VAL E 551 REMARK 465 GLN E 552 REMARK 465 GLN E 553 REMARK 465 GLN E 554 REMARK 465 SER E 555 REMARK 465 ASN E 556 REMARK 465 LEU E 557 REMARK 465 LEU E 558 REMARK 465 ARG E 559 REMARK 465 ALA E 560 REMARK 465 PRO E 561 REMARK 465 GLU E 562 REMARK 465 ALA E 563 REMARK 465 GLN E 564 REMARK 465 GLN E 565 REMARK 465 HIS E 566 REMARK 465 LEU E 567 REMARK 465 LEU E 568 REMARK 465 LYS E 569 REMARK 465 LEU E 570 REMARK 465 THR E 571 REMARK 465 VAL E 572 REMARK 465 TRP E 573 REMARK 465 GLY E 574 REMARK 465 ILE E 575 REMARK 465 LYS E 576 REMARK 465 GLN E 577 REMARK 465 LEU E 578 REMARK 465 GLN E 579 REMARK 465 ALA E 580 REMARK 465 ARG E 581 REMARK 465 VAL E 582 REMARK 465 LEU E 583 REMARK 465 ALA E 584 REMARK 465 VAL E 585 REMARK 465 GLU E 586 REMARK 465 ARG E 587 REMARK 465 TYR E 588 REMARK 465 LEU E 589 REMARK 465 ARG E 590 REMARK 465 ASP E 591 REMARK 465 GLN E 592 REMARK 465 GLN E 593 REMARK 465 LEU E 594 REMARK 465 LEU E 595 REMARK 465 GLY E 596 REMARK 465 ILE E 597 REMARK 465 TRP E 598 REMARK 465 GLY E 599 REMARK 465 CYS E 600 REMARK 465 SER E 601 REMARK 465 GLY E 602 REMARK 465 LYS E 603 REMARK 465 LEU E 604 REMARK 465 ILE E 605 REMARK 465 CYS E 606 REMARK 465 CYS E 607 REMARK 465 THR E 608 REMARK 465 ASN E 609 REMARK 465 VAL E 610 REMARK 465 PRO E 611 REMARK 465 TRP E 612 REMARK 465 ASN E 613 REMARK 465 SER E 614 REMARK 465 SER E 615 REMARK 465 TRP E 616 REMARK 465 SER E 617 REMARK 465 ASN E 618 REMARK 465 ARG E 619 REMARK 465 ASN E 620 REMARK 465 LEU E 621 REMARK 465 SER E 622 REMARK 465 GLU E 623 REMARK 465 ILE E 624 REMARK 465 TRP E 625 REMARK 465 ASP E 626 REMARK 465 ASN E 627 REMARK 465 MET E 628 REMARK 465 THR E 629 REMARK 465 TRP E 630 REMARK 465 LEU E 631 REMARK 465 GLN E 632 REMARK 465 TRP E 633 REMARK 465 ASP E 634 REMARK 465 LYS E 635 REMARK 465 GLU E 636 REMARK 465 ILE E 637 REMARK 465 SER E 638 REMARK 465 ASN E 639 REMARK 465 TYR E 640 REMARK 465 THR E 641 REMARK 465 GLN E 642 REMARK 465 ILE E 643 REMARK 465 ILE E 644 REMARK 465 TYR E 645 REMARK 465 GLY E 646 REMARK 465 LEU E 647 REMARK 465 LEU E 648 REMARK 465 GLU E 649 REMARK 465 GLU E 650 REMARK 465 SER E 651 REMARK 465 GLN E 652 REMARK 465 ASN E 653 REMARK 465 GLN E 654 REMARK 465 GLN E 655 REMARK 465 GLU E 656 REMARK 465 LYS E 657 REMARK 465 ASN E 658 REMARK 465 GLU E 659 REMARK 465 GLN E 660 REMARK 465 ASP E 661 REMARK 465 LEU E 662 REMARK 465 LEU E 663 REMARK 465 ALA E 664 REMARK 465 LEU E 665 REMARK 465 ASP E 666 REMARK 465 MET F 19 REMARK 465 GLY F 20 REMARK 465 SER F 21 REMARK 465 LEU F 22 REMARK 465 GLN F 23 REMARK 465 PRO F 24 REMARK 465 LEU F 25 REMARK 465 ALA F 26 REMARK 465 THR F 27 REMARK 465 LEU F 28 REMARK 465 TYR F 29 REMARK 465 LEU F 30 REMARK 465 LEU F 31 REMARK 465 GLY F 32 REMARK 465 MET F 33 REMARK 465 LEU F 34 REMARK 465 VAL F 35 REMARK 465 ALA F 36 REMARK 465 SER F 37 REMARK 465 VAL F 38 REMARK 465 LEU F 39 REMARK 465 ALA F 40 REMARK 465 ALA F 41 REMARK 465 GLU F 42 REMARK 465 ASN F 43 REMARK 465 LEU F 44 REMARK 465 TRP F 45 REMARK 465 VAL F 46 REMARK 465 THR F 47 REMARK 465 VAL F 48 REMARK 465 TYR F 49 REMARK 465 TYR F 50 REMARK 465 GLY F 51 REMARK 465 VAL F 52 REMARK 465 PRO F 53 REMARK 465 VAL F 54 REMARK 465 TRP F 55 REMARK 465 LYS F 56 REMARK 465 GLU F 57 REMARK 465 ALA F 58 REMARK 465 LYS F 59 REMARK 465 THR F 60 REMARK 465 THR F 61 REMARK 465 LEU F 62 REMARK 465 PHE F 63 REMARK 465 CYS F 64 REMARK 465 ALA F 65 REMARK 465 SER F 66 REMARK 465 ASP F 67 REMARK 465 ALA F 68 REMARK 465 ARG F 69 REMARK 465 ALA F 70 REMARK 465 TYR F 71 REMARK 465 GLU F 72 REMARK 465 LYS F 73 REMARK 465 GLU F 74 REMARK 465 VAL F 75 REMARK 465 HIS F 76 REMARK 465 ASN F 77 REMARK 465 VAL F 78 REMARK 465 TRP F 79 REMARK 465 ALA F 80 REMARK 465 THR F 81 REMARK 465 HIS F 82 REMARK 465 ALA F 83 REMARK 465 CYS F 84 REMARK 465 VAL F 85 REMARK 465 PRO F 86 REMARK 465 THR F 87 REMARK 465 ASP F 88 REMARK 465 PRO F 89 REMARK 465 SER F 90 REMARK 465 PRO F 91 REMARK 465 GLN F 92 REMARK 465 GLU F 93 REMARK 465 LEU F 94 REMARK 465 VAL F 95 REMARK 465 LEU F 96 REMARK 465 GLY F 97 REMARK 465 ASN F 98 REMARK 465 VAL F 99 REMARK 465 THR F 100 REMARK 465 GLU F 101 REMARK 465 ASN F 102 REMARK 465 PHE F 103 REMARK 465 ASN F 104 REMARK 465 MET F 105 REMARK 465 TRP F 106 REMARK 465 LYS F 107 REMARK 465 ASN F 108 REMARK 465 ASP F 109 REMARK 465 MET F 110 REMARK 465 VAL F 111 REMARK 465 ASP F 112 REMARK 465 GLN F 113 REMARK 465 MET F 114 REMARK 465 HIS F 115 REMARK 465 GLU F 116 REMARK 465 ASP F 117 REMARK 465 ILE F 118 REMARK 465 ILE F 119 REMARK 465 SER F 120 REMARK 465 LEU F 121 REMARK 465 TRP F 122 REMARK 465 ASP F 123 REMARK 465 GLN F 124 REMARK 465 SER F 125 REMARK 465 LEU F 126 REMARK 465 LYS F 127 REMARK 465 PRO F 128 REMARK 465 CYS F 129 REMARK 465 VAL F 130 REMARK 465 LYS F 131 REMARK 465 LEU F 132 REMARK 465 THR F 133 REMARK 465 PRO F 134 REMARK 465 LEU F 135 REMARK 465 CYS F 136 REMARK 465 VAL F 137 REMARK 465 THR F 138 REMARK 465 LEU F 139 REMARK 465 ILE F 140 REMARK 465 CYS F 141 REMARK 465 SER F 142 REMARK 465 ASP F 143 REMARK 465 ALA F 144 REMARK 465 THR F 145 REMARK 465 VAL F 146 REMARK 465 LYS F 147 REMARK 465 THR F 148 REMARK 465 GLY F 149 REMARK 465 THR F 150 REMARK 465 VAL F 151 REMARK 465 GLU F 152 REMARK 465 GLU F 153 REMARK 465 MET F 154 REMARK 465 LYS F 155 REMARK 465 ASN F 156 REMARK 465 CYS F 157 REMARK 465 SER F 158 REMARK 465 PHE F 159 REMARK 465 ASN F 160 REMARK 465 THR F 161 REMARK 465 THR F 162 REMARK 465 THR F 163 REMARK 465 GLU F 164 REMARK 465 ILE F 165 REMARK 465 ARG F 166 REMARK 465 ASP F 167 REMARK 465 LYS F 168 REMARK 465 GLU F 169 REMARK 465 LYS F 170 REMARK 465 LYS F 171 REMARK 465 GLU F 172 REMARK 465 TYR F 173 REMARK 465 ALA F 174 REMARK 465 LEU F 175 REMARK 465 PHE F 176 REMARK 465 TYR F 177 REMARK 465 LYS F 178 REMARK 465 PRO F 179 REMARK 465 ASP F 180 REMARK 465 ILE F 181 REMARK 465 VAL F 182 REMARK 465 PRO F 183 REMARK 465 LEU F 184 REMARK 465 SER F 185 REMARK 465 GLU F 186 REMARK 465 THR F 187 REMARK 465 ASN F 188 REMARK 465 ASN F 189 REMARK 465 THR F 190 REMARK 465 SER F 191 REMARK 465 GLU F 192 REMARK 465 TYR F 193 REMARK 465 ARG F 194 REMARK 465 LEU F 195 REMARK 465 ILE F 196 REMARK 465 ASN F 197 REMARK 465 CYS F 198 REMARK 465 ASN F 199 REMARK 465 THR F 200 REMARK 465 SER F 201 REMARK 465 ALA F 202 REMARK 465 CYS F 203 REMARK 465 THR F 204 REMARK 465 GLN F 205 REMARK 465 ALA F 206 REMARK 465 CYS F 207 REMARK 465 PRO F 208 REMARK 465 LYS F 209 REMARK 465 VAL F 210 REMARK 465 THR F 211 REMARK 465 PHE F 212 REMARK 465 GLU F 213 REMARK 465 PRO F 214 REMARK 465 ILE F 215 REMARK 465 PRO F 216 REMARK 465 ILE F 217 REMARK 465 HIS F 218 REMARK 465 TYR F 219 REMARK 465 CYS F 220 REMARK 465 ALA F 221 REMARK 465 PRO F 222 REMARK 465 ALA F 223 REMARK 465 GLY F 224 REMARK 465 TYR F 225 REMARK 465 ALA F 226 REMARK 465 ILE F 227 REMARK 465 LEU F 228 REMARK 465 LYS F 229 REMARK 465 CYS F 230 REMARK 465 ASN F 231 REMARK 465 ASP F 232 REMARK 465 GLU F 233 REMARK 465 THR F 234 REMARK 465 PHE F 235 REMARK 465 ASN F 236 REMARK 465 GLY F 237 REMARK 465 THR F 238 REMARK 465 GLY F 239 REMARK 465 PRO F 240 REMARK 465 CYS F 241 REMARK 465 SER F 242 REMARK 465 ASN F 243 REMARK 465 VAL F 244 REMARK 465 SER F 245 REMARK 465 THR F 246 REMARK 465 VAL F 247 REMARK 465 GLN F 248 REMARK 465 CYS F 249 REMARK 465 THR F 250 REMARK 465 HIS F 251 REMARK 465 GLY F 252 REMARK 465 ILE F 253 REMARK 465 ARG F 254 REMARK 465 PRO F 255 REMARK 465 VAL F 256 REMARK 465 VAL F 257 REMARK 465 SER F 258 REMARK 465 THR F 259 REMARK 465 GLN F 260 REMARK 465 LEU F 261 REMARK 465 LEU F 262 REMARK 465 LEU F 263 REMARK 465 ASN F 264 REMARK 465 GLY F 265 REMARK 465 SER F 266 REMARK 465 LEU F 267 REMARK 465 ALA F 268 REMARK 465 GLU F 269 REMARK 465 LYS F 270 REMARK 465 GLU F 271 REMARK 465 ILE F 272 REMARK 465 VAL F 273 REMARK 465 ILE F 274 REMARK 465 ARG F 275 REMARK 465 SER F 276 REMARK 465 GLU F 277 REMARK 465 ASN F 278 REMARK 465 LEU F 279 REMARK 465 THR F 280 REMARK 465 ASN F 281 REMARK 465 ASN F 282 REMARK 465 ALA F 283 REMARK 465 LYS F 284 REMARK 465 ILE F 285 REMARK 465 ILE F 286 REMARK 465 ILE F 287 REMARK 465 VAL F 288 REMARK 465 HIS F 289 REMARK 465 LEU F 290 REMARK 465 HIS F 291 REMARK 465 THR F 292 REMARK 465 PRO F 293 REMARK 465 VAL F 294 REMARK 465 GLU F 295 REMARK 465 ILE F 296 REMARK 465 VAL F 297 REMARK 465 CYS F 298 REMARK 465 THR F 299 REMARK 465 ARG F 300 REMARK 465 PRO F 301 REMARK 465 ASN F 302 REMARK 465 ASN F 303 REMARK 465 ASN F 304 REMARK 465 THR F 305 REMARK 465 ARG F 306 REMARK 465 LYS F 307 REMARK 465 SER F 308 REMARK 465 VAL F 309 REMARK 465 ARG F 310 REMARK 465 ILE F 311 REMARK 465 GLY F 312 REMARK 465 PRO F 313 REMARK 465 GLY F 314 REMARK 465 GLN F 315 REMARK 465 THR F 316 REMARK 465 PHE F 317 REMARK 465 TYR F 318 REMARK 465 ALA F 319 REMARK 465 THR F 320 REMARK 465 GLY F 321 REMARK 465 ASP F 322 REMARK 465 ILE F 323 REMARK 465 ILE F 324 REMARK 465 GLY F 325 REMARK 465 ASP F 326 REMARK 465 ILE F 327 REMARK 465 LYS F 328 REMARK 465 GLN F 329 REMARK 465 ALA F 330 REMARK 465 HIS F 331 REMARK 465 CYS F 332 REMARK 465 ASN F 333 REMARK 465 ILE F 334 REMARK 465 SER F 335 REMARK 465 GLU F 336 REMARK 465 GLU F 337 REMARK 465 LYS F 338 REMARK 465 TRP F 339 REMARK 465 ASN F 340 REMARK 465 ASP F 341 REMARK 465 THR F 342 REMARK 465 LEU F 343 REMARK 465 GLN F 344 REMARK 465 LYS F 345 REMARK 465 VAL F 346 REMARK 465 GLY F 347 REMARK 465 ILE F 348 REMARK 465 GLU F 349 REMARK 465 LEU F 350 REMARK 465 GLN F 351 REMARK 465 LYS F 352 REMARK 465 HIS F 353 REMARK 465 PHE F 354 REMARK 465 PRO F 355 REMARK 465 ASN F 356 REMARK 465 LYS F 357 REMARK 465 THR F 358 REMARK 465 ILE F 359 REMARK 465 LYS F 360 REMARK 465 TYR F 361 REMARK 465 ASN F 362 REMARK 465 GLN F 363 REMARK 465 SER F 364 REMARK 465 ALA F 365 REMARK 465 GLY F 366 REMARK 465 GLY F 367 REMARK 465 ASP F 368 REMARK 465 MET F 369 REMARK 465 GLU F 370 REMARK 465 ILE F 371 REMARK 465 THR F 372 REMARK 465 THR F 373 REMARK 465 HIS F 374 REMARK 465 SER F 375 REMARK 465 PHE F 376 REMARK 465 ASN F 377 REMARK 465 CYS F 378 REMARK 465 GLY F 379 REMARK 465 GLY F 380 REMARK 465 GLU F 381 REMARK 465 PHE F 382 REMARK 465 PHE F 383 REMARK 465 TYR F 384 REMARK 465 CYS F 385 REMARK 465 ASN F 386 REMARK 465 THR F 387 REMARK 465 SER F 388 REMARK 465 ASN F 389 REMARK 465 LEU F 390 REMARK 465 PHE F 391 REMARK 465 ASN F 392 REMARK 465 GLY F 393 REMARK 465 THR F 394 REMARK 465 TYR F 395 REMARK 465 ASN F 396 REMARK 465 GLY F 397 REMARK 465 THR F 398 REMARK 465 TYR F 399 REMARK 465 ILE F 400 REMARK 465 SER F 401 REMARK 465 THR F 402 REMARK 465 ASN F 403 REMARK 465 SER F 404 REMARK 465 SER F 405 REMARK 465 ALA F 406 REMARK 465 ASN F 407 REMARK 465 SER F 408 REMARK 465 THR F 409 REMARK 465 SER F 410 REMARK 465 THR F 411 REMARK 465 ILE F 412 REMARK 465 THR F 413 REMARK 465 LEU F 414 REMARK 465 GLN F 415 REMARK 465 CYS F 416 REMARK 465 ARG F 417 REMARK 465 ILE F 418 REMARK 465 LYS F 419 REMARK 465 GLN F 420 REMARK 465 ILE F 421 REMARK 465 ILE F 422 REMARK 465 ASN F 423 REMARK 465 MET F 424 REMARK 465 TRP F 425 REMARK 465 GLN F 426 REMARK 465 GLY F 427 REMARK 465 VAL F 428 REMARK 465 GLY F 429 REMARK 465 ARG F 430 REMARK 465 CYS F 431 REMARK 465 MET F 432 REMARK 465 TYR F 433 REMARK 465 ALA F 434 REMARK 465 PRO F 435 REMARK 465 PRO F 436 REMARK 465 ILE F 437 REMARK 465 ALA F 438 REMARK 465 GLY F 439 REMARK 465 ASN F 440 REMARK 465 ILE F 441 REMARK 465 THR F 442 REMARK 465 CYS F 443 REMARK 465 ARG F 444 REMARK 465 SER F 445 REMARK 465 ASN F 446 REMARK 465 ILE F 447 REMARK 465 THR F 448 REMARK 465 GLY F 449 REMARK 465 LEU F 450 REMARK 465 LEU F 451 REMARK 465 LEU F 452 REMARK 465 THR F 453 REMARK 465 ARG F 454 REMARK 465 ASP F 455 REMARK 465 GLY F 456 REMARK 465 GLY F 457 REMARK 465 THR F 458 REMARK 465 ASN F 459 REMARK 465 SER F 460 REMARK 465 ASN F 461 REMARK 465 GLU F 462 REMARK 465 THR F 463 REMARK 465 GLU F 464 REMARK 465 THR F 465 REMARK 465 PHE F 466 REMARK 465 ARG F 467 REMARK 465 PRO F 468 REMARK 465 ALA F 469 REMARK 465 GLY F 470 REMARK 465 GLY F 471 REMARK 465 ASP F 472 REMARK 465 MET F 473 REMARK 465 ARG F 474 REMARK 465 ASP F 475 REMARK 465 ASN F 476 REMARK 465 TRP F 477 REMARK 465 ARG F 478 REMARK 465 SER F 479 REMARK 465 GLU F 480 REMARK 465 LEU F 481 REMARK 465 TYR F 482 REMARK 465 LYS F 483 REMARK 465 TYR F 484 REMARK 465 LYS F 485 REMARK 465 VAL F 486 REMARK 465 VAL F 487 REMARK 465 LYS F 488 REMARK 465 ILE F 489 REMARK 465 GLU F 490 REMARK 465 PRO F 491 REMARK 465 LEU F 492 REMARK 465 GLY F 493 REMARK 465 VAL F 494 REMARK 465 ALA F 495 REMARK 465 PRO F 496 REMARK 465 THR F 497 REMARK 465 ARG F 498 REMARK 465 CYS F 499 REMARK 465 LYS F 500 REMARK 465 ARG F 501 REMARK 465 ARG F 502 REMARK 465 VAL F 503 REMARK 465 VAL F 504 REMARK 465 GLY F 505 REMARK 465 ARG F 506 REMARK 465 ARG F 507 REMARK 465 ARG F 508 REMARK 465 ARG F 509 REMARK 465 ARG F 510 REMARK 465 ARG F 511 REMARK 465 ALA F 512 REMARK 465 VAL F 513 REMARK 465 GLY F 514 REMARK 465 ILE F 515 REMARK 465 GLY F 516 REMARK 465 ALA F 517 REMARK 465 VAL F 518 REMARK 465 PHE F 519 REMARK 465 LEU F 520 REMARK 465 GLY F 521 REMARK 465 ILE F 548 REMARK 465 VAL F 549 REMARK 465 GLN F 550 REMARK 465 GLN F 551 REMARK 465 GLN F 552 REMARK 465 SER F 553 REMARK 465 ASN F 554 REMARK 465 LEU F 555 REMARK 465 LEU F 556 REMARK 465 ARG F 557 REMARK 465 ALA F 558 REMARK 465 PRO F 559 REMARK 465 GLU F 560 REMARK 465 ALA F 561 REMARK 465 GLN F 562 REMARK 465 GLN F 563 REMARK 465 HIS F 564 REMARK 465 LEU F 565 REMARK 465 LEU F 566 REMARK 465 LYS F 567 REMARK 465 LEU F 568 REMARK 465 MET G -18 REMARK 465 GLY G -17 REMARK 465 TRP G -16 REMARK 465 SER G -15 REMARK 465 CYS G -14 REMARK 465 ILE G -13 REMARK 465 ILE G -12 REMARK 465 LEU G -11 REMARK 465 PHE G -10 REMARK 465 LEU G -9 REMARK 465 VAL G -8 REMARK 465 ALA G -7 REMARK 465 THR G -6 REMARK 465 ALA G -5 REMARK 465 THR G -4 REMARK 465 GLY G -3 REMARK 465 VAL G -2 REMARK 465 HIS G -1 REMARK 465 SER G 0 REMARK 465 GLN H 1 REMARK 465 SER H 2 REMARK 465 ALA H 3 REMARK 465 LEU H 4 REMARK 465 MET I 9 REMARK 465 GLY I 10 REMARK 465 SER I 11 REMARK 465 LEU I 12 REMARK 465 GLN I 13 REMARK 465 PRO I 14 REMARK 465 LEU I 15 REMARK 465 ALA I 16 REMARK 465 THR I 17 REMARK 465 LEU I 18 REMARK 465 TYR I 19 REMARK 465 LEU I 20 REMARK 465 LEU I 21 REMARK 465 GLY I 22 REMARK 465 MET I 23 REMARK 465 LEU I 24 REMARK 465 VAL I 25 REMARK 465 ALA I 26 REMARK 465 SER I 27 REMARK 465 VAL I 28 REMARK 465 LEU I 29 REMARK 465 ALA I 30 REMARK 465 ALA I 31 REMARK 465 GLU I 32 REMARK 465 VAL I 506 REMARK 465 GLY I 507 REMARK 465 ARG I 508 REMARK 465 ARG I 509 REMARK 465 ARG I 510 REMARK 465 ARG I 511 REMARK 465 ARG I 512 REMARK 465 ARG I 513 REMARK 465 ALA I 514 REMARK 465 VAL I 515 REMARK 465 GLY I 516 REMARK 465 ILE I 517 REMARK 465 GLY I 518 REMARK 465 ALA I 519 REMARK 465 VAL I 520 REMARK 465 PHE I 521 REMARK 465 LEU I 522 REMARK 465 GLY I 523 REMARK 465 PHE I 524 REMARK 465 LEU I 525 REMARK 465 GLY I 526 REMARK 465 ALA I 527 REMARK 465 ALA I 528 REMARK 465 GLY I 529 REMARK 465 SER I 530 REMARK 465 THR I 531 REMARK 465 MET I 532 REMARK 465 GLY I 533 REMARK 465 ALA I 534 REMARK 465 ALA I 535 REMARK 465 SER I 536 REMARK 465 MET I 537 REMARK 465 THR I 538 REMARK 465 LEU I 539 REMARK 465 THR I 540 REMARK 465 VAL I 541 REMARK 465 GLN I 542 REMARK 465 ALA I 543 REMARK 465 ARG I 544 REMARK 465 ASN I 545 REMARK 465 LEU I 546 REMARK 465 LEU I 547 REMARK 465 SER I 548 REMARK 465 GLY I 549 REMARK 465 ILE I 550 REMARK 465 VAL I 551 REMARK 465 GLN I 552 REMARK 465 GLN I 553 REMARK 465 GLN I 554 REMARK 465 SER I 555 REMARK 465 ASN I 556 REMARK 465 LEU I 557 REMARK 465 LEU I 558 REMARK 465 ARG I 559 REMARK 465 ALA I 560 REMARK 465 PRO I 561 REMARK 465 GLU I 562 REMARK 465 ALA I 563 REMARK 465 GLN I 564 REMARK 465 GLN I 565 REMARK 465 HIS I 566 REMARK 465 LEU I 567 REMARK 465 LEU I 568 REMARK 465 LYS I 569 REMARK 465 LEU I 570 REMARK 465 THR I 571 REMARK 465 VAL I 572 REMARK 465 TRP I 573 REMARK 465 GLY I 574 REMARK 465 ILE I 575 REMARK 465 LYS I 576 REMARK 465 GLN I 577 REMARK 465 LEU I 578 REMARK 465 GLN I 579 REMARK 465 ALA I 580 REMARK 465 ARG I 581 REMARK 465 VAL I 582 REMARK 465 LEU I 583 REMARK 465 ALA I 584 REMARK 465 VAL I 585 REMARK 465 GLU I 586 REMARK 465 ARG I 587 REMARK 465 TYR I 588 REMARK 465 LEU I 589 REMARK 465 ARG I 590 REMARK 465 ASP I 591 REMARK 465 GLN I 592 REMARK 465 GLN I 593 REMARK 465 LEU I 594 REMARK 465 LEU I 595 REMARK 465 GLY I 596 REMARK 465 ILE I 597 REMARK 465 TRP I 598 REMARK 465 GLY I 599 REMARK 465 CYS I 600 REMARK 465 SER I 601 REMARK 465 GLY I 602 REMARK 465 LYS I 603 REMARK 465 LEU I 604 REMARK 465 ILE I 605 REMARK 465 CYS I 606 REMARK 465 CYS I 607 REMARK 465 THR I 608 REMARK 465 ASN I 609 REMARK 465 VAL I 610 REMARK 465 PRO I 611 REMARK 465 TRP I 612 REMARK 465 ASN I 613 REMARK 465 SER I 614 REMARK 465 SER I 615 REMARK 465 TRP I 616 REMARK 465 SER I 617 REMARK 465 ASN I 618 REMARK 465 ARG I 619 REMARK 465 ASN I 620 REMARK 465 LEU I 621 REMARK 465 SER I 622 REMARK 465 GLU I 623 REMARK 465 ILE I 624 REMARK 465 TRP I 625 REMARK 465 ASP I 626 REMARK 465 ASN I 627 REMARK 465 MET I 628 REMARK 465 THR I 629 REMARK 465 TRP I 630 REMARK 465 LEU I 631 REMARK 465 GLN I 632 REMARK 465 TRP I 633 REMARK 465 ASP I 634 REMARK 465 LYS I 635 REMARK 465 GLU I 636 REMARK 465 ILE I 637 REMARK 465 SER I 638 REMARK 465 ASN I 639 REMARK 465 TYR I 640 REMARK 465 THR I 641 REMARK 465 GLN I 642 REMARK 465 ILE I 643 REMARK 465 ILE I 644 REMARK 465 TYR I 645 REMARK 465 GLY I 646 REMARK 465 LEU I 647 REMARK 465 LEU I 648 REMARK 465 GLU I 649 REMARK 465 GLU I 650 REMARK 465 SER I 651 REMARK 465 GLN I 652 REMARK 465 ASN I 653 REMARK 465 GLN I 654 REMARK 465 GLN I 655 REMARK 465 GLU I 656 REMARK 465 LYS I 657 REMARK 465 ASN I 658 REMARK 465 GLU I 659 REMARK 465 GLN I 660 REMARK 465 ASP I 661 REMARK 465 LEU I 662 REMARK 465 LEU I 663 REMARK 465 ALA I 664 REMARK 465 LEU I 665 REMARK 465 ASP I 666 REMARK 465 MET J 19 REMARK 465 GLY J 20 REMARK 465 SER J 21 REMARK 465 LEU J 22 REMARK 465 GLN J 23 REMARK 465 PRO J 24 REMARK 465 LEU J 25 REMARK 465 ALA J 26 REMARK 465 THR J 27 REMARK 465 LEU J 28 REMARK 465 TYR J 29 REMARK 465 LEU J 30 REMARK 465 LEU J 31 REMARK 465 GLY J 32 REMARK 465 MET J 33 REMARK 465 LEU J 34 REMARK 465 VAL J 35 REMARK 465 ALA J 36 REMARK 465 SER J 37 REMARK 465 VAL J 38 REMARK 465 LEU J 39 REMARK 465 ALA J 40 REMARK 465 ALA J 41 REMARK 465 GLU J 42 REMARK 465 ASN J 43 REMARK 465 LEU J 44 REMARK 465 TRP J 45 REMARK 465 VAL J 46 REMARK 465 THR J 47 REMARK 465 VAL J 48 REMARK 465 TYR J 49 REMARK 465 TYR J 50 REMARK 465 GLY J 51 REMARK 465 VAL J 52 REMARK 465 PRO J 53 REMARK 465 VAL J 54 REMARK 465 TRP J 55 REMARK 465 LYS J 56 REMARK 465 GLU J 57 REMARK 465 ALA J 58 REMARK 465 LYS J 59 REMARK 465 THR J 60 REMARK 465 THR J 61 REMARK 465 LEU J 62 REMARK 465 PHE J 63 REMARK 465 CYS J 64 REMARK 465 ALA J 65 REMARK 465 SER J 66 REMARK 465 ASP J 67 REMARK 465 ALA J 68 REMARK 465 ARG J 69 REMARK 465 ALA J 70 REMARK 465 TYR J 71 REMARK 465 GLU J 72 REMARK 465 LYS J 73 REMARK 465 GLU J 74 REMARK 465 VAL J 75 REMARK 465 HIS J 76 REMARK 465 ASN J 77 REMARK 465 VAL J 78 REMARK 465 TRP J 79 REMARK 465 ALA J 80 REMARK 465 THR J 81 REMARK 465 HIS J 82 REMARK 465 ALA J 83 REMARK 465 CYS J 84 REMARK 465 VAL J 85 REMARK 465 PRO J 86 REMARK 465 THR J 87 REMARK 465 ASP J 88 REMARK 465 PRO J 89 REMARK 465 SER J 90 REMARK 465 PRO J 91 REMARK 465 GLN J 92 REMARK 465 GLU J 93 REMARK 465 LEU J 94 REMARK 465 VAL J 95 REMARK 465 LEU J 96 REMARK 465 GLY J 97 REMARK 465 ASN J 98 REMARK 465 VAL J 99 REMARK 465 THR J 100 REMARK 465 GLU J 101 REMARK 465 ASN J 102 REMARK 465 PHE J 103 REMARK 465 ASN J 104 REMARK 465 MET J 105 REMARK 465 TRP J 106 REMARK 465 LYS J 107 REMARK 465 ASN J 108 REMARK 465 ASP J 109 REMARK 465 MET J 110 REMARK 465 VAL J 111 REMARK 465 ASP J 112 REMARK 465 GLN J 113 REMARK 465 MET J 114 REMARK 465 HIS J 115 REMARK 465 GLU J 116 REMARK 465 ASP J 117 REMARK 465 ILE J 118 REMARK 465 ILE J 119 REMARK 465 SER J 120 REMARK 465 LEU J 121 REMARK 465 TRP J 122 REMARK 465 ASP J 123 REMARK 465 GLN J 124 REMARK 465 SER J 125 REMARK 465 LEU J 126 REMARK 465 LYS J 127 REMARK 465 PRO J 128 REMARK 465 CYS J 129 REMARK 465 VAL J 130 REMARK 465 LYS J 131 REMARK 465 LEU J 132 REMARK 465 THR J 133 REMARK 465 PRO J 134 REMARK 465 LEU J 135 REMARK 465 CYS J 136 REMARK 465 VAL J 137 REMARK 465 THR J 138 REMARK 465 LEU J 139 REMARK 465 ILE J 140 REMARK 465 CYS J 141 REMARK 465 SER J 142 REMARK 465 ASP J 143 REMARK 465 ALA J 144 REMARK 465 THR J 145 REMARK 465 VAL J 146 REMARK 465 LYS J 147 REMARK 465 THR J 148 REMARK 465 GLY J 149 REMARK 465 THR J 150 REMARK 465 VAL J 151 REMARK 465 GLU J 152 REMARK 465 GLU J 153 REMARK 465 MET J 154 REMARK 465 LYS J 155 REMARK 465 ASN J 156 REMARK 465 CYS J 157 REMARK 465 SER J 158 REMARK 465 PHE J 159 REMARK 465 ASN J 160 REMARK 465 THR J 161 REMARK 465 THR J 162 REMARK 465 THR J 163 REMARK 465 GLU J 164 REMARK 465 ILE J 165 REMARK 465 ARG J 166 REMARK 465 ASP J 167 REMARK 465 LYS J 168 REMARK 465 GLU J 169 REMARK 465 LYS J 170 REMARK 465 LYS J 171 REMARK 465 GLU J 172 REMARK 465 TYR J 173 REMARK 465 ALA J 174 REMARK 465 LEU J 175 REMARK 465 PHE J 176 REMARK 465 TYR J 177 REMARK 465 LYS J 178 REMARK 465 PRO J 179 REMARK 465 ASP J 180 REMARK 465 ILE J 181 REMARK 465 VAL J 182 REMARK 465 PRO J 183 REMARK 465 LEU J 184 REMARK 465 SER J 185 REMARK 465 GLU J 186 REMARK 465 THR J 187 REMARK 465 ASN J 188 REMARK 465 ASN J 189 REMARK 465 THR J 190 REMARK 465 SER J 191 REMARK 465 GLU J 192 REMARK 465 TYR J 193 REMARK 465 ARG J 194 REMARK 465 LEU J 195 REMARK 465 ILE J 196 REMARK 465 ASN J 197 REMARK 465 CYS J 198 REMARK 465 ASN J 199 REMARK 465 THR J 200 REMARK 465 SER J 201 REMARK 465 ALA J 202 REMARK 465 CYS J 203 REMARK 465 THR J 204 REMARK 465 GLN J 205 REMARK 465 ALA J 206 REMARK 465 CYS J 207 REMARK 465 PRO J 208 REMARK 465 LYS J 209 REMARK 465 VAL J 210 REMARK 465 THR J 211 REMARK 465 PHE J 212 REMARK 465 GLU J 213 REMARK 465 PRO J 214 REMARK 465 ILE J 215 REMARK 465 PRO J 216 REMARK 465 ILE J 217 REMARK 465 HIS J 218 REMARK 465 TYR J 219 REMARK 465 CYS J 220 REMARK 465 ALA J 221 REMARK 465 PRO J 222 REMARK 465 ALA J 223 REMARK 465 GLY J 224 REMARK 465 TYR J 225 REMARK 465 ALA J 226 REMARK 465 ILE J 227 REMARK 465 LEU J 228 REMARK 465 LYS J 229 REMARK 465 CYS J 230 REMARK 465 ASN J 231 REMARK 465 ASP J 232 REMARK 465 GLU J 233 REMARK 465 THR J 234 REMARK 465 PHE J 235 REMARK 465 ASN J 236 REMARK 465 GLY J 237 REMARK 465 THR J 238 REMARK 465 GLY J 239 REMARK 465 PRO J 240 REMARK 465 CYS J 241 REMARK 465 SER J 242 REMARK 465 ASN J 243 REMARK 465 VAL J 244 REMARK 465 SER J 245 REMARK 465 THR J 246 REMARK 465 VAL J 247 REMARK 465 GLN J 248 REMARK 465 CYS J 249 REMARK 465 THR J 250 REMARK 465 HIS J 251 REMARK 465 GLY J 252 REMARK 465 ILE J 253 REMARK 465 ARG J 254 REMARK 465 PRO J 255 REMARK 465 VAL J 256 REMARK 465 VAL J 257 REMARK 465 SER J 258 REMARK 465 THR J 259 REMARK 465 GLN J 260 REMARK 465 LEU J 261 REMARK 465 LEU J 262 REMARK 465 LEU J 263 REMARK 465 ASN J 264 REMARK 465 GLY J 265 REMARK 465 SER J 266 REMARK 465 LEU J 267 REMARK 465 ALA J 268 REMARK 465 GLU J 269 REMARK 465 LYS J 270 REMARK 465 GLU J 271 REMARK 465 ILE J 272 REMARK 465 VAL J 273 REMARK 465 ILE J 274 REMARK 465 ARG J 275 REMARK 465 SER J 276 REMARK 465 GLU J 277 REMARK 465 ASN J 278 REMARK 465 LEU J 279 REMARK 465 THR J 280 REMARK 465 ASN J 281 REMARK 465 ASN J 282 REMARK 465 ALA J 283 REMARK 465 LYS J 284 REMARK 465 ILE J 285 REMARK 465 ILE J 286 REMARK 465 ILE J 287 REMARK 465 VAL J 288 REMARK 465 HIS J 289 REMARK 465 LEU J 290 REMARK 465 HIS J 291 REMARK 465 THR J 292 REMARK 465 PRO J 293 REMARK 465 VAL J 294 REMARK 465 GLU J 295 REMARK 465 ILE J 296 REMARK 465 VAL J 297 REMARK 465 CYS J 298 REMARK 465 THR J 299 REMARK 465 ARG J 300 REMARK 465 PRO J 301 REMARK 465 ASN J 302 REMARK 465 ASN J 303 REMARK 465 ASN J 304 REMARK 465 THR J 305 REMARK 465 ARG J 306 REMARK 465 LYS J 307 REMARK 465 SER J 308 REMARK 465 VAL J 309 REMARK 465 ARG J 310 REMARK 465 ILE J 311 REMARK 465 GLY J 312 REMARK 465 PRO J 313 REMARK 465 GLY J 314 REMARK 465 GLN J 315 REMARK 465 THR J 316 REMARK 465 PHE J 317 REMARK 465 TYR J 318 REMARK 465 ALA J 319 REMARK 465 THR J 320 REMARK 465 GLY J 321 REMARK 465 ASP J 322 REMARK 465 ILE J 323 REMARK 465 ILE J 324 REMARK 465 GLY J 325 REMARK 465 ASP J 326 REMARK 465 ILE J 327 REMARK 465 LYS J 328 REMARK 465 GLN J 329 REMARK 465 ALA J 330 REMARK 465 HIS J 331 REMARK 465 CYS J 332 REMARK 465 ASN J 333 REMARK 465 ILE J 334 REMARK 465 SER J 335 REMARK 465 GLU J 336 REMARK 465 GLU J 337 REMARK 465 LYS J 338 REMARK 465 TRP J 339 REMARK 465 ASN J 340 REMARK 465 ASP J 341 REMARK 465 THR J 342 REMARK 465 LEU J 343 REMARK 465 GLN J 344 REMARK 465 LYS J 345 REMARK 465 VAL J 346 REMARK 465 GLY J 347 REMARK 465 ILE J 348 REMARK 465 GLU J 349 REMARK 465 LEU J 350 REMARK 465 GLN J 351 REMARK 465 LYS J 352 REMARK 465 HIS J 353 REMARK 465 PHE J 354 REMARK 465 PRO J 355 REMARK 465 ASN J 356 REMARK 465 LYS J 357 REMARK 465 THR J 358 REMARK 465 ILE J 359 REMARK 465 LYS J 360 REMARK 465 TYR J 361 REMARK 465 ASN J 362 REMARK 465 GLN J 363 REMARK 465 SER J 364 REMARK 465 ALA J 365 REMARK 465 GLY J 366 REMARK 465 GLY J 367 REMARK 465 ASP J 368 REMARK 465 MET J 369 REMARK 465 GLU J 370 REMARK 465 ILE J 371 REMARK 465 THR J 372 REMARK 465 THR J 373 REMARK 465 HIS J 374 REMARK 465 SER J 375 REMARK 465 PHE J 376 REMARK 465 ASN J 377 REMARK 465 CYS J 378 REMARK 465 GLY J 379 REMARK 465 GLY J 380 REMARK 465 GLU J 381 REMARK 465 PHE J 382 REMARK 465 PHE J 383 REMARK 465 TYR J 384 REMARK 465 CYS J 385 REMARK 465 ASN J 386 REMARK 465 THR J 387 REMARK 465 SER J 388 REMARK 465 ASN J 389 REMARK 465 LEU J 390 REMARK 465 PHE J 391 REMARK 465 ASN J 392 REMARK 465 GLY J 393 REMARK 465 THR J 394 REMARK 465 TYR J 395 REMARK 465 ASN J 396 REMARK 465 GLY J 397 REMARK 465 THR J 398 REMARK 465 TYR J 399 REMARK 465 ILE J 400 REMARK 465 SER J 401 REMARK 465 THR J 402 REMARK 465 ASN J 403 REMARK 465 SER J 404 REMARK 465 SER J 405 REMARK 465 ALA J 406 REMARK 465 ASN J 407 REMARK 465 SER J 408 REMARK 465 THR J 409 REMARK 465 SER J 410 REMARK 465 THR J 411 REMARK 465 ILE J 412 REMARK 465 THR J 413 REMARK 465 LEU J 414 REMARK 465 GLN J 415 REMARK 465 CYS J 416 REMARK 465 ARG J 417 REMARK 465 ILE J 418 REMARK 465 LYS J 419 REMARK 465 GLN J 420 REMARK 465 ILE J 421 REMARK 465 ILE J 422 REMARK 465 ASN J 423 REMARK 465 MET J 424 REMARK 465 TRP J 425 REMARK 465 GLN J 426 REMARK 465 GLY J 427 REMARK 465 VAL J 428 REMARK 465 GLY J 429 REMARK 465 ARG J 430 REMARK 465 CYS J 431 REMARK 465 MET J 432 REMARK 465 TYR J 433 REMARK 465 ALA J 434 REMARK 465 PRO J 435 REMARK 465 PRO J 436 REMARK 465 ILE J 437 REMARK 465 ALA J 438 REMARK 465 GLY J 439 REMARK 465 ASN J 440 REMARK 465 ILE J 441 REMARK 465 THR J 442 REMARK 465 CYS J 443 REMARK 465 ARG J 444 REMARK 465 SER J 445 REMARK 465 ASN J 446 REMARK 465 ILE J 447 REMARK 465 THR J 448 REMARK 465 GLY J 449 REMARK 465 LEU J 450 REMARK 465 LEU J 451 REMARK 465 LEU J 452 REMARK 465 THR J 453 REMARK 465 ARG J 454 REMARK 465 ASP J 455 REMARK 465 GLY J 456 REMARK 465 GLY J 457 REMARK 465 THR J 458 REMARK 465 ASN J 459 REMARK 465 SER J 460 REMARK 465 ASN J 461 REMARK 465 GLU J 462 REMARK 465 THR J 463 REMARK 465 GLU J 464 REMARK 465 THR J 465 REMARK 465 PHE J 466 REMARK 465 ARG J 467 REMARK 465 PRO J 468 REMARK 465 ALA J 469 REMARK 465 GLY J 470 REMARK 465 GLY J 471 REMARK 465 ASP J 472 REMARK 465 MET J 473 REMARK 465 ARG J 474 REMARK 465 ASP J 475 REMARK 465 ASN J 476 REMARK 465 TRP J 477 REMARK 465 ARG J 478 REMARK 465 SER J 479 REMARK 465 GLU J 480 REMARK 465 LEU J 481 REMARK 465 TYR J 482 REMARK 465 LYS J 483 REMARK 465 TYR J 484 REMARK 465 LYS J 485 REMARK 465 VAL J 486 REMARK 465 VAL J 487 REMARK 465 LYS J 488 REMARK 465 ILE J 489 REMARK 465 GLU J 490 REMARK 465 PRO J 491 REMARK 465 LEU J 492 REMARK 465 GLY J 493 REMARK 465 VAL J 494 REMARK 465 ALA J 495 REMARK 465 PRO J 496 REMARK 465 THR J 497 REMARK 465 ARG J 498 REMARK 465 CYS J 499 REMARK 465 LYS J 500 REMARK 465 ARG J 501 REMARK 465 ARG J 502 REMARK 465 VAL J 503 REMARK 465 VAL J 504 REMARK 465 GLY J 505 REMARK 465 ARG J 506 REMARK 465 ARG J 507 REMARK 465 ARG J 508 REMARK 465 ARG J 509 REMARK 465 ARG J 510 REMARK 465 ARG J 511 REMARK 465 ALA J 512 REMARK 465 VAL J 513 REMARK 465 GLY J 514 REMARK 465 ILE J 515 REMARK 465 GLY J 516 REMARK 465 ALA J 517 REMARK 465 VAL J 518 REMARK 465 PHE J 519 REMARK 465 LEU J 520 REMARK 465 GLY J 521 REMARK 465 ILE J 548 REMARK 465 VAL J 549 REMARK 465 GLN J 550 REMARK 465 GLN J 551 REMARK 465 GLN J 552 REMARK 465 SER J 553 REMARK 465 ASN J 554 REMARK 465 LEU J 555 REMARK 465 LEU J 556 REMARK 465 ARG J 557 REMARK 465 ALA J 558 REMARK 465 PRO J 559 REMARK 465 GLU J 560 REMARK 465 ALA J 561 REMARK 465 GLN J 562 REMARK 465 GLN J 563 REMARK 465 HIS J 564 REMARK 465 LEU J 565 REMARK 465 LEU J 566 REMARK 465 LYS J 567 REMARK 465 LEU J 568 REMARK 465 MET K -18 REMARK 465 GLY K -17 REMARK 465 TRP K -16 REMARK 465 SER K -15 REMARK 465 CYS K -14 REMARK 465 ILE K -13 REMARK 465 ILE K -12 REMARK 465 LEU K -11 REMARK 465 PHE K -10 REMARK 465 LEU K -9 REMARK 465 VAL K -8 REMARK 465 ALA K -7 REMARK 465 THR K -6 REMARK 465 ALA K -5 REMARK 465 THR K -4 REMARK 465 GLY K -3 REMARK 465 VAL K -2 REMARK 465 HIS K -1 REMARK 465 SER K 0 REMARK 465 GLN L 1 REMARK 465 SER L 2 REMARK 465 ALA L 3 REMARK 465 LEU L 4 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 186 51.56 -94.58 REMARK 500 GLN A 258 -11.41 70.29 REMARK 500 LEU A 277 -5.21 66.84 REMARK 500 PHE A 391 71.13 -100.44 REMARK 500 ASN A 396 -169.42 -115.08 REMARK 500 TYR A 400 96.69 -69.72 REMARK 500 SER A 462 38.09 -95.48 REMARK 500 ASN B 616 -30.93 -132.53 REMARK 500 HIS E 66 53.07 -93.56 REMARK 500 LEU E 86 -60.65 -92.71 REMARK 500 THR E 148 -74.73 57.67 REMARK 500 ASN E 186 51.78 -94.48 REMARK 500 GLN E 258 -8.38 70.37 REMARK 500 LEU E 277 -16.60 67.70 REMARK 500 ASN E 404 -91.19 53.08 REMARK 500 ASN E 425 74.68 -100.77 REMARK 500 SER E 462 38.03 -95.97 REMARK 500 TYR F 638 -4.89 68.26 REMARK 500 PRO G 112 45.83 -84.99 REMARK 500 HIS I 66 32.49 -95.95 REMARK 500 GLU I 83 34.01 -91.87 REMARK 500 GLU I 150 -107.64 54.42 REMARK 500 GLU I 151 19.49 58.73 REMARK 500 ASN I 186 51.11 -95.65 REMARK 500 GLN I 258 -11.65 70.60 REMARK 500 ASN I 262 37.40 37.80 REMARK 500 ASN I 404 -72.20 62.51 REMARK 500 ASN I 425 75.65 -101.19 REMARK 500 ASN I 463 -78.49 59.44 REMARK 500 ASN J 616 -30.16 -132.34 REMARK 500 REMARK 500 REMARK: NULL REMARK 610 REMARK 610 MISSING HETEROATOM REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 610 I=INSERTION CODE): REMARK 610 M RES C SSEQI REMARK 610 NAG i 1 REMARK 610 NAG v 1 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 8DTO RELATED DB: PDB REMARK 900 VACCINE ELICITED ANTIBODY MU89 BOUND TO CH848.D949.10.17_N133D_ REMARK 900 N138T.DS.SOSIP.664 HIV-1 ENV TRIMER REMARK 900 RELATED ID: EMD-27776 RELATED DB: EMDB REMARK 900 VACCINE ELICITED ANTIBODY MU89+S27Y BOUND TO CH848.D949.10.17_N133D_ REMARK 900 N138T.DS.SOSIP.664 HIV-1 ENV TRIMER DBREF 8DY6 A 9 666 PDB 8DY6 8DY6 9 666 DBREF 8DY6 B 19 664 PDB 8DY6 8DY6 19 664 DBREF 8DY6 C -18 126 PDB 8DY6 8DY6 -18 126 DBREF 8DY6 D 1 110 PDB 8DY6 8DY6 1 110 DBREF 8DY6 E 9 666 PDB 8DY6 8DY6 9 666 DBREF 8DY6 F 19 664 PDB 8DY6 8DY6 19 664 DBREF 8DY6 G -18 126 PDB 8DY6 8DY6 -18 126 DBREF 8DY6 H 1 110 PDB 8DY6 8DY6 1 110 DBREF 8DY6 I 9 666 PDB 8DY6 8DY6 9 666 DBREF 8DY6 J 19 664 PDB 8DY6 8DY6 19 664 DBREF 8DY6 K -18 126 PDB 8DY6 8DY6 -18 126 DBREF 8DY6 L 1 110 PDB 8DY6 8DY6 1 110 SEQRES 1 A 646 MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR LEU LEU SEQRES 2 A 646 GLY MET LEU VAL ALA SER VAL LEU ALA ALA GLU ASN LEU SEQRES 3 A 646 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 4 A 646 ALA LYS THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 5 A 646 TYR GLU LYS GLU VAL HIS ASN VAL TRP ALA THR HIS ALA SEQRES 6 A 646 CYS VAL PRO THR ASP PRO SER PRO GLN GLU LEU VAL LEU SEQRES 7 A 646 GLY ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASP SEQRES 8 A 646 MET VAL ASP GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 9 A 646 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 10 A 646 CYS VAL THR LEU ILE CYS SER ASP ALA THR VAL LYS THR SEQRES 11 A 646 GLY THR VAL GLU GLU MET LYS ASN CYS SER PHE ASN THR SEQRES 12 A 646 THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU TYR ALA SEQRES 13 A 646 LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER GLU THR SEQRES 14 A 646 ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS ASN THR SEQRES 15 A 646 SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR PHE GLU SEQRES 16 A 646 PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY TYR ALA SEQRES 17 A 646 ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY THR GLY SEQRES 18 A 646 PRO CYS SER ASN VAL SER THR VAL GLN CYS THR HIS GLY SEQRES 19 A 646 ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SEQRES 20 A 646 SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER GLU ASN SEQRES 21 A 646 LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS LEU HIS SEQRES 22 A 646 THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN ASN ASN SEQRES 23 A 646 THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN THR PHE SEQRES 24 A 646 TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS GLN ALA SEQRES 25 A 646 HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP THR LEU SEQRES 26 A 646 GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE PRO ASN SEQRES 27 A 646 LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY ASP MET SEQRES 28 A 646 GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 29 A 646 PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY THR TYR SEQRES 30 A 646 ASN GLY THR TYR ILE SER THR ASN SER SER ALA ASN SER SEQRES 31 A 646 THR SER THR ILE THR LEU GLN CYS ARG ILE LYS GLN ILE SEQRES 32 A 646 ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET TYR ALA SEQRES 33 A 646 PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER ASN ILE SEQRES 34 A 646 THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR ASN SER SEQRES 35 A 646 ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY ASP MET SEQRES 36 A 646 ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL SEQRES 37 A 646 VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS SEQRES 38 A 646 LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG ALA SEQRES 39 A 646 VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY ALA SEQRES 40 A 646 ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU THR SEQRES 41 A 646 VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN GLN SEQRES 42 A 646 GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN HIS SEQRES 43 A 646 LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 44 A 646 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 45 A 646 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 46 A 646 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 47 A 646 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 48 A 646 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 49 A 646 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 50 A 646 ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 B 646 MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR LEU LEU SEQRES 2 B 646 GLY MET LEU VAL ALA SER VAL LEU ALA ALA GLU ASN LEU SEQRES 3 B 646 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 4 B 646 ALA LYS THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 5 B 646 TYR GLU LYS GLU VAL HIS ASN VAL TRP ALA THR HIS ALA SEQRES 6 B 646 CYS VAL PRO THR ASP PRO SER PRO GLN GLU LEU VAL LEU SEQRES 7 B 646 GLY ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASP SEQRES 8 B 646 MET VAL ASP GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 9 B 646 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 10 B 646 CYS VAL THR LEU ILE CYS SER ASP ALA THR VAL LYS THR SEQRES 11 B 646 GLY THR VAL GLU GLU MET LYS ASN CYS SER PHE ASN THR SEQRES 12 B 646 THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU TYR ALA SEQRES 13 B 646 LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER GLU THR SEQRES 14 B 646 ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS ASN THR SEQRES 15 B 646 SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR PHE GLU SEQRES 16 B 646 PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY TYR ALA SEQRES 17 B 646 ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY THR GLY SEQRES 18 B 646 PRO CYS SER ASN VAL SER THR VAL GLN CYS THR HIS GLY SEQRES 19 B 646 ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SEQRES 20 B 646 SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER GLU ASN SEQRES 21 B 646 LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS LEU HIS SEQRES 22 B 646 THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN ASN ASN SEQRES 23 B 646 THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN THR PHE SEQRES 24 B 646 TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS GLN ALA SEQRES 25 B 646 HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP THR LEU SEQRES 26 B 646 GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE PRO ASN SEQRES 27 B 646 LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY ASP MET SEQRES 28 B 646 GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 29 B 646 PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY THR TYR SEQRES 30 B 646 ASN GLY THR TYR ILE SER THR ASN SER SER ALA ASN SER SEQRES 31 B 646 THR SER THR ILE THR LEU GLN CYS ARG ILE LYS GLN ILE SEQRES 32 B 646 ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET TYR ALA SEQRES 33 B 646 PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER ASN ILE SEQRES 34 B 646 THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR ASN SER SEQRES 35 B 646 ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY ASP MET SEQRES 36 B 646 ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL SEQRES 37 B 646 VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS SEQRES 38 B 646 LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG ALA SEQRES 39 B 646 VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY ALA SEQRES 40 B 646 ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU THR SEQRES 41 B 646 VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN GLN SEQRES 42 B 646 GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN HIS SEQRES 43 B 646 LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 44 B 646 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 45 B 646 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 46 B 646 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 47 B 646 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 48 B 646 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 49 B 646 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 50 B 646 ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 C 145 MET GLY TRP SER CYS ILE ILE LEU PHE LEU VAL ALA THR SEQRES 2 C 145 ALA THR GLY VAL HIS SER GLN VAL GLN LEU VAL GLN SER SEQRES 3 C 145 GLY ALA GLU VAL LYS LYS PRO GLY ALA SER VAL LYS VAL SEQRES 4 C 145 SER CYS LYS ALA SER GLY TYR ARG PHE THR ASP HIS TYR SEQRES 5 C 145 ILE HIS TRP VAL ARG GLN ALA PRO GLY GLN GLY PRO GLU SEQRES 6 C 145 TRP MET GLY TRP ILE ASN THR SER SER GLY ARG SER ASN SEQRES 7 C 145 PHE ALA GLN LYS PHE GLN GLY ARG VAL THR MET THR ARG SEQRES 8 C 145 ASP THR SER ILE SER THR ALA TYR MET GLU LEU ASN ARG SEQRES 9 C 145 LEU LYS SER ASP ASP THR ALA VAL TYR TYR CYS THR THR SEQRES 10 C 145 GLY SER TRP ILE SER LEU TYR TYR ASP SER SER GLY TYR SEQRES 11 C 145 PRO ASN PHE ASP TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 12 C 145 VAL THR SEQRES 1 D 110 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 D 110 PRO GLY GLN PRO ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 D 110 TYR ASP VAL GLY ASN TYR ASP LEU VAL SER TRP TYR GLN SEQRES 4 D 110 GLN HIS PRO GLY ASN ALA PRO LYS TYR MET ILE TYR GLU SEQRES 5 D 110 VAL THR LYS ARG PRO ALA GLY ILE SER ASN ARG PHE SER SEQRES 6 D 110 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 D 110 GLY LEU GLN ALA GLU ASP ALA ALA ASP TYR TYR CYS CYS SEQRES 8 D 110 SER TYR ALA GLY SER SER THR VAL ILE PHE GLY GLY GLY SEQRES 9 D 110 THR LYS VAL THR VAL LEU SEQRES 1 E 646 MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR LEU LEU SEQRES 2 E 646 GLY MET LEU VAL ALA SER VAL LEU ALA ALA GLU ASN LEU SEQRES 3 E 646 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 4 E 646 ALA LYS THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 5 E 646 TYR GLU LYS GLU VAL HIS ASN VAL TRP ALA THR HIS ALA SEQRES 6 E 646 CYS VAL PRO THR ASP PRO SER PRO GLN GLU LEU VAL LEU SEQRES 7 E 646 GLY ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASP SEQRES 8 E 646 MET VAL ASP GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 9 E 646 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 10 E 646 CYS VAL THR LEU ILE CYS SER ASP ALA THR VAL LYS THR SEQRES 11 E 646 GLY THR VAL GLU GLU MET LYS ASN CYS SER PHE ASN THR SEQRES 12 E 646 THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU TYR ALA SEQRES 13 E 646 LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER GLU THR SEQRES 14 E 646 ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS ASN THR SEQRES 15 E 646 SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR PHE GLU SEQRES 16 E 646 PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY TYR ALA SEQRES 17 E 646 ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY THR GLY SEQRES 18 E 646 PRO CYS SER ASN VAL SER THR VAL GLN CYS THR HIS GLY SEQRES 19 E 646 ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SEQRES 20 E 646 SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER GLU ASN SEQRES 21 E 646 LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS LEU HIS SEQRES 22 E 646 THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN ASN ASN SEQRES 23 E 646 THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN THR PHE SEQRES 24 E 646 TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS GLN ALA SEQRES 25 E 646 HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP THR LEU SEQRES 26 E 646 GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE PRO ASN SEQRES 27 E 646 LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY ASP MET SEQRES 28 E 646 GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 29 E 646 PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY THR TYR SEQRES 30 E 646 ASN GLY THR TYR ILE SER THR ASN SER SER ALA ASN SER SEQRES 31 E 646 THR SER THR ILE THR LEU GLN CYS ARG ILE LYS GLN ILE SEQRES 32 E 646 ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET TYR ALA SEQRES 33 E 646 PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER ASN ILE SEQRES 34 E 646 THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR ASN SER SEQRES 35 E 646 ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY ASP MET SEQRES 36 E 646 ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL SEQRES 37 E 646 VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS SEQRES 38 E 646 LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG ALA SEQRES 39 E 646 VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY ALA SEQRES 40 E 646 ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU THR SEQRES 41 E 646 VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN GLN SEQRES 42 E 646 GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN HIS SEQRES 43 E 646 LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 44 E 646 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 45 E 646 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 46 E 646 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 47 E 646 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 48 E 646 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 49 E 646 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 50 E 646 ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 F 646 MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR LEU LEU SEQRES 2 F 646 GLY MET LEU VAL ALA SER VAL LEU ALA ALA GLU ASN LEU SEQRES 3 F 646 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 4 F 646 ALA LYS THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 5 F 646 TYR GLU LYS GLU VAL HIS ASN VAL TRP ALA THR HIS ALA SEQRES 6 F 646 CYS VAL PRO THR ASP PRO SER PRO GLN GLU LEU VAL LEU SEQRES 7 F 646 GLY ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASP SEQRES 8 F 646 MET VAL ASP GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 9 F 646 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 10 F 646 CYS VAL THR LEU ILE CYS SER ASP ALA THR VAL LYS THR SEQRES 11 F 646 GLY THR VAL GLU GLU MET LYS ASN CYS SER PHE ASN THR SEQRES 12 F 646 THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU TYR ALA SEQRES 13 F 646 LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER GLU THR SEQRES 14 F 646 ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS ASN THR SEQRES 15 F 646 SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR PHE GLU SEQRES 16 F 646 PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY TYR ALA SEQRES 17 F 646 ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY THR GLY SEQRES 18 F 646 PRO CYS SER ASN VAL SER THR VAL GLN CYS THR HIS GLY SEQRES 19 F 646 ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SEQRES 20 F 646 SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER GLU ASN SEQRES 21 F 646 LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS LEU HIS SEQRES 22 F 646 THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN ASN ASN SEQRES 23 F 646 THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN THR PHE SEQRES 24 F 646 TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS GLN ALA SEQRES 25 F 646 HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP THR LEU SEQRES 26 F 646 GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE PRO ASN SEQRES 27 F 646 LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY ASP MET SEQRES 28 F 646 GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 29 F 646 PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY THR TYR SEQRES 30 F 646 ASN GLY THR TYR ILE SER THR ASN SER SER ALA ASN SER SEQRES 31 F 646 THR SER THR ILE THR LEU GLN CYS ARG ILE LYS GLN ILE SEQRES 32 F 646 ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET TYR ALA SEQRES 33 F 646 PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER ASN ILE SEQRES 34 F 646 THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR ASN SER SEQRES 35 F 646 ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY ASP MET SEQRES 36 F 646 ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL SEQRES 37 F 646 VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS SEQRES 38 F 646 LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG ALA SEQRES 39 F 646 VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY ALA SEQRES 40 F 646 ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU THR SEQRES 41 F 646 VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN GLN SEQRES 42 F 646 GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN HIS SEQRES 43 F 646 LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 44 F 646 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 45 F 646 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 46 F 646 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 47 F 646 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 48 F 646 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 49 F 646 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 50 F 646 ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 G 145 MET GLY TRP SER CYS ILE ILE LEU PHE LEU VAL ALA THR SEQRES 2 G 145 ALA THR GLY VAL HIS SER GLN VAL GLN LEU VAL GLN SER SEQRES 3 G 145 GLY ALA GLU VAL LYS LYS PRO GLY ALA SER VAL LYS VAL SEQRES 4 G 145 SER CYS LYS ALA SER GLY TYR ARG PHE THR ASP HIS TYR SEQRES 5 G 145 ILE HIS TRP VAL ARG GLN ALA PRO GLY GLN GLY PRO GLU SEQRES 6 G 145 TRP MET GLY TRP ILE ASN THR SER SER GLY ARG SER ASN SEQRES 7 G 145 PHE ALA GLN LYS PHE GLN GLY ARG VAL THR MET THR ARG SEQRES 8 G 145 ASP THR SER ILE SER THR ALA TYR MET GLU LEU ASN ARG SEQRES 9 G 145 LEU LYS SER ASP ASP THR ALA VAL TYR TYR CYS THR THR SEQRES 10 G 145 GLY SER TRP ILE SER LEU TYR TYR ASP SER SER GLY TYR SEQRES 11 G 145 PRO ASN PHE ASP TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 12 G 145 VAL THR SEQRES 1 H 110 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 H 110 PRO GLY GLN PRO ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 H 110 TYR ASP VAL GLY ASN TYR ASP LEU VAL SER TRP TYR GLN SEQRES 4 H 110 GLN HIS PRO GLY ASN ALA PRO LYS TYR MET ILE TYR GLU SEQRES 5 H 110 VAL THR LYS ARG PRO ALA GLY ILE SER ASN ARG PHE SER SEQRES 6 H 110 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 H 110 GLY LEU GLN ALA GLU ASP ALA ALA ASP TYR TYR CYS CYS SEQRES 8 H 110 SER TYR ALA GLY SER SER THR VAL ILE PHE GLY GLY GLY SEQRES 9 H 110 THR LYS VAL THR VAL LEU SEQRES 1 I 646 MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR LEU LEU SEQRES 2 I 646 GLY MET LEU VAL ALA SER VAL LEU ALA ALA GLU ASN LEU SEQRES 3 I 646 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 4 I 646 ALA LYS THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 5 I 646 TYR GLU LYS GLU VAL HIS ASN VAL TRP ALA THR HIS ALA SEQRES 6 I 646 CYS VAL PRO THR ASP PRO SER PRO GLN GLU LEU VAL LEU SEQRES 7 I 646 GLY ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASP SEQRES 8 I 646 MET VAL ASP GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 9 I 646 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 10 I 646 CYS VAL THR LEU ILE CYS SER ASP ALA THR VAL LYS THR SEQRES 11 I 646 GLY THR VAL GLU GLU MET LYS ASN CYS SER PHE ASN THR SEQRES 12 I 646 THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU TYR ALA SEQRES 13 I 646 LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER GLU THR SEQRES 14 I 646 ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS ASN THR SEQRES 15 I 646 SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR PHE GLU SEQRES 16 I 646 PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY TYR ALA SEQRES 17 I 646 ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY THR GLY SEQRES 18 I 646 PRO CYS SER ASN VAL SER THR VAL GLN CYS THR HIS GLY SEQRES 19 I 646 ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SEQRES 20 I 646 SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER GLU ASN SEQRES 21 I 646 LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS LEU HIS SEQRES 22 I 646 THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN ASN ASN SEQRES 23 I 646 THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN THR PHE SEQRES 24 I 646 TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS GLN ALA SEQRES 25 I 646 HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP THR LEU SEQRES 26 I 646 GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE PRO ASN SEQRES 27 I 646 LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY ASP MET SEQRES 28 I 646 GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 29 I 646 PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY THR TYR SEQRES 30 I 646 ASN GLY THR TYR ILE SER THR ASN SER SER ALA ASN SER SEQRES 31 I 646 THR SER THR ILE THR LEU GLN CYS ARG ILE LYS GLN ILE SEQRES 32 I 646 ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET TYR ALA SEQRES 33 I 646 PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER ASN ILE SEQRES 34 I 646 THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR ASN SER SEQRES 35 I 646 ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY ASP MET SEQRES 36 I 646 ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL SEQRES 37 I 646 VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS SEQRES 38 I 646 LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG ALA SEQRES 39 I 646 VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY ALA SEQRES 40 I 646 ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU THR SEQRES 41 I 646 VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN GLN SEQRES 42 I 646 GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN HIS SEQRES 43 I 646 LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 44 I 646 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 45 I 646 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 46 I 646 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 47 I 646 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 48 I 646 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 49 I 646 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 50 I 646 ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 J 646 MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR LEU LEU SEQRES 2 J 646 GLY MET LEU VAL ALA SER VAL LEU ALA ALA GLU ASN LEU SEQRES 3 J 646 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 4 J 646 ALA LYS THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 5 J 646 TYR GLU LYS GLU VAL HIS ASN VAL TRP ALA THR HIS ALA SEQRES 6 J 646 CYS VAL PRO THR ASP PRO SER PRO GLN GLU LEU VAL LEU SEQRES 7 J 646 GLY ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASP SEQRES 8 J 646 MET VAL ASP GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 9 J 646 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 10 J 646 CYS VAL THR LEU ILE CYS SER ASP ALA THR VAL LYS THR SEQRES 11 J 646 GLY THR VAL GLU GLU MET LYS ASN CYS SER PHE ASN THR SEQRES 12 J 646 THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU TYR ALA SEQRES 13 J 646 LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER GLU THR SEQRES 14 J 646 ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS ASN THR SEQRES 15 J 646 SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR PHE GLU SEQRES 16 J 646 PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY TYR ALA SEQRES 17 J 646 ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY THR GLY SEQRES 18 J 646 PRO CYS SER ASN VAL SER THR VAL GLN CYS THR HIS GLY SEQRES 19 J 646 ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SEQRES 20 J 646 SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER GLU ASN SEQRES 21 J 646 LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS LEU HIS SEQRES 22 J 646 THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN ASN ASN SEQRES 23 J 646 THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN THR PHE SEQRES 24 J 646 TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS GLN ALA SEQRES 25 J 646 HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP THR LEU SEQRES 26 J 646 GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE PRO ASN SEQRES 27 J 646 LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY ASP MET SEQRES 28 J 646 GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 29 J 646 PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY THR TYR SEQRES 30 J 646 ASN GLY THR TYR ILE SER THR ASN SER SER ALA ASN SER SEQRES 31 J 646 THR SER THR ILE THR LEU GLN CYS ARG ILE LYS GLN ILE SEQRES 32 J 646 ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET TYR ALA SEQRES 33 J 646 PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER ASN ILE SEQRES 34 J 646 THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR ASN SER SEQRES 35 J 646 ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY ASP MET SEQRES 36 J 646 ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL SEQRES 37 J 646 VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS SEQRES 38 J 646 LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG ALA SEQRES 39 J 646 VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY ALA SEQRES 40 J 646 ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU THR SEQRES 41 J 646 VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN GLN SEQRES 42 J 646 GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN HIS SEQRES 43 J 646 LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 44 J 646 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 45 J 646 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 46 J 646 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 47 J 646 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 48 J 646 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 49 J 646 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 50 J 646 ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 K 145 MET GLY TRP SER CYS ILE ILE LEU PHE LEU VAL ALA THR SEQRES 2 K 145 ALA THR GLY VAL HIS SER GLN VAL GLN LEU VAL GLN SER SEQRES 3 K 145 GLY ALA GLU VAL LYS LYS PRO GLY ALA SER VAL LYS VAL SEQRES 4 K 145 SER CYS LYS ALA SER GLY TYR ARG PHE THR ASP HIS TYR SEQRES 5 K 145 ILE HIS TRP VAL ARG GLN ALA PRO GLY GLN GLY PRO GLU SEQRES 6 K 145 TRP MET GLY TRP ILE ASN THR SER SER GLY ARG SER ASN SEQRES 7 K 145 PHE ALA GLN LYS PHE GLN GLY ARG VAL THR MET THR ARG SEQRES 8 K 145 ASP THR SER ILE SER THR ALA TYR MET GLU LEU ASN ARG SEQRES 9 K 145 LEU LYS SER ASP ASP THR ALA VAL TYR TYR CYS THR THR SEQRES 10 K 145 GLY SER TRP ILE SER LEU TYR TYR ASP SER SER GLY TYR SEQRES 11 K 145 PRO ASN PHE ASP TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 12 K 145 VAL THR SEQRES 1 L 110 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 L 110 PRO GLY GLN PRO ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 L 110 TYR ASP VAL GLY ASN TYR ASP LEU VAL SER TRP TYR GLN SEQRES 4 L 110 GLN HIS PRO GLY ASN ALA PRO LYS TYR MET ILE TYR GLU SEQRES 5 L 110 VAL THR LYS ARG PRO ALA GLY ILE SER ASN ARG PHE SER SEQRES 6 L 110 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 L 110 GLY LEU GLN ALA GLU ASP ALA ALA ASP TYR TYR CYS CYS SEQRES 8 L 110 SER TYR ALA GLY SER SER THR VAL ILE PHE GLY GLY GLY SEQRES 9 L 110 THR LYS VAL THR VAL LEU HET NAG A 701 14 HET NAG A 702 14 HET NAG A 703 14 HET NAG E 701 14 HET NAG E 702 14 HET NAG E 703 14 HET NAG E 704 14 HET NAG I 701 14 HET NAG I 702 14 HET NAG M 1 14 HET NAG M 2 14 HET BMA M 3 11 HET NAG N 1 14 HET NAG N 2 14 HET BMA N 3 11 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET MAN O 4 11 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET NAG Q 1 14 HET NAG Q 2 14 HET BMA Q 3 11 HET NAG R 1 14 HET NAG R 2 14 HET BMA R 3 11 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET MAN U 6 11 HET MAN U 7 11 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET BMA W 3 11 HET MAN W 4 11 HET MAN W 5 11 HET NAG X 1 14 HET NAG X 2 14 HET NAG X 3 14 HET NAG Y 1 14 HET NAG Y 2 14 HET BMA Y 3 11 HET NAG Z 1 14 HET NAG Z 2 14 HET BMA Z 3 11 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET BMA b 3 11 HET NAG c 1 14 HET NAG c 2 14 HET BMA c 3 11 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET NAG e 1 14 HET NAG e 2 14 HET NAG f 1 14 HET NAG f 2 14 HET NAG g 1 14 HET NAG g 2 14 HET BMA g 3 11 HET MAN g 4 11 HET MAN g 5 11 HET MAN g 6 11 HET MAN g 7 11 HET NAG h 1 14 HET NAG h 2 14 HET NAG i 1 14 HET NAG i 2 14 HET BMA i 3 11 HET MAN i 4 11 HET MAN i 5 11 HET NAG j 1 14 HET NAG j 2 14 HET NAG j 3 14 HET NAG k 1 14 HET NAG k 2 14 HET BMA k 3 11 HET NAG l 1 14 HET NAG l 2 14 HET NAG m 1 14 HET NAG m 2 14 HET BMA m 3 11 HET NAG n 1 14 HET NAG n 2 14 HET BMA n 3 11 HET NAG o 1 14 HET NAG o 2 14 HET BMA o 3 11 HET NAG p 1 14 HET NAG p 2 14 HET BMA p 3 11 HET NAG q 1 14 HET NAG q 2 14 HET NAG r 1 14 HET NAG r 2 14 HET NAG s 1 14 HET NAG s 2 14 HET NAG t 1 14 HET NAG t 2 14 HET BMA t 3 11 HET MAN t 4 11 HET MAN t 5 11 HET MAN t 6 11 HET MAN t 7 11 HET NAG u 1 14 HET NAG u 2 14 HET NAG v 1 14 HET NAG v 2 14 HET BMA v 3 11 HET MAN v 4 11 HET MAN v 5 11 HET NAG w 1 14 HET NAG w 2 14 HET NAG w 3 14 HET NAG x 1 14 HET NAG x 2 14 HET BMA x 3 11 HET NAG y 1 14 HET NAG y 2 14 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 13 NAG 90(C8 H15 N O6) FORMUL 22 BMA 23(C6 H12 O6) FORMUL 24 MAN 19(C6 H12 O6) HELIX 1 AA1 ALA A 70 CYS A 74 5 5 HELIX 2 AA2 ASN A 98 LYS A 117 1 20 HELIX 3 AA3 ASN A 195 THR A 198 5 4 HELIX 4 AA4 GLU A 335 LYS A 351 1 17 HELIX 5 AA5 ASP A 368 THR A 373 1 6 HELIX 6 AA6 THR A 403 ALA A 407 5 5 HELIX 7 AA7 MET A 475 SER A 481 1 7 HELIX 8 AA8 THR B 529 SER B 534 1 6 HELIX 9 AA9 LEU B 537 ASN B 543 1 7 HELIX 10 AB1 VAL B 570 GLY B 597 1 28 HELIX 11 AB2 ASN B 618 ASP B 624 1 7 HELIX 12 AB3 THR B 627 SER B 636 1 10 HELIX 13 AB4 THR B 639 ALA B 662 1 24 HELIX 14 AB5 ARG C 28 THR C 30 5 3 HELIX 15 AB6 GLN C 62 GLN C 65 5 4 HELIX 16 AB7 LYS C 87 THR C 91 5 5 HELIX 17 AB8 GLN D 81 ALA D 85 5 5 HELIX 18 AB9 ALA E 70 CYS E 74 5 5 HELIX 19 AC1 ASP E 99 LYS E 117 1 19 HELIX 20 AC2 ASN E 195 THR E 198 5 4 HELIX 21 AC3 GLU E 335 LYS E 351 1 17 HELIX 22 AC4 ASP E 368 THR E 373 1 6 HELIX 23 AC5 TRP E 427 VAL E 430 5 4 HELIX 24 AC6 MET E 475 SER E 481 1 7 HELIX 25 AC7 THR F 529 ASN F 543 1 15 HELIX 26 AC8 VAL F 570 GLY F 597 1 28 HELIX 27 AC9 ASN F 618 ASP F 624 1 7 HELIX 28 AD1 THR F 627 ILE F 635 1 9 HELIX 29 AD2 TYR F 638 ALA F 662 1 25 HELIX 30 AD3 ARG G 28 THR G 30 5 3 HELIX 31 AD4 GLN G 62 GLN G 65 5 4 HELIX 32 AD5 LYS G 87 THR G 91 5 5 HELIX 33 AD6 GLN H 81 ALA H 85 5 5 HELIX 34 AD7 ALA I 70 CYS I 74 5 5 HELIX 35 AD8 ASN I 98 LYS I 117 1 20 HELIX 36 AD9 ASN I 195 THR I 198 5 4 HELIX 37 AE1 GLU I 335 LYS I 351 1 17 HELIX 38 AE2 ASP I 368 THR I 373 1 6 HELIX 39 AE3 MET I 475 ARG I 480 1 6 HELIX 40 AE4 THR J 529 SER J 534 1 6 HELIX 41 AE5 LEU J 537 ARG J 542 1 6 HELIX 42 AE6 VAL J 570 GLY J 597 1 28 HELIX 43 AE7 ASN J 618 ASP J 624 1 7 HELIX 44 AE8 THR J 627 ILE J 635 1 9 HELIX 45 AE9 TYR J 638 LEU J 663 1 26 HELIX 46 AF1 ARG K 28 THR K 30 5 3 HELIX 47 AF2 GLN K 62 GLN K 65 5 4 HELIX 48 AF3 LYS K 87 THR K 91 5 5 HELIX 49 AF4 GLN L 81 ALA L 85 5 5 SHEET 1 AA1 2 VAL A 36 TYR A 40 0 SHEET 2 AA1 2 LEU A 494 PRO A 498 -1 O ALA A 497 N THR A 37 SHEET 1 AA2 5 TRP A 45 GLU A 47 0 SHEET 2 AA2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AA2 5 TYR A 223 CYS A 228 -1 N ALA A 224 O VAL A 489 SHEET 4 AA2 5 VAL A 242 VAL A 245 -1 O SER A 243 N LYS A 227 SHEET 5 AA2 5 LEU A 84 VAL A 85 -1 N LEU A 84 O THR A 244 SHEET 1 AA3 2 PHE A 53 ALA A 55 0 SHEET 2 AA3 2 HIS A 216 CYS A 218 -1 O CYS A 218 N PHE A 53 SHEET 1 AA4 2 GLU A 91 ASN A 94 0 SHEET 2 AA4 2 THR A 236 CYS A 239 -1 O CYS A 239 N GLU A 91 SHEET 1 AA5 5 GLU A 167 TYR A 175 0 SHEET 2 AA5 5 MET A 152 THR A 160 -1 N CYS A 155 O ALA A 172 SHEET 3 AA5 5 LEU A 129 ASP A 133 -1 N ILE A 130 O SER A 156 SHEET 4 AA5 5 GLU A 190 LEU A 193 -1 O TYR A 191 N LEU A 129 SHEET 5 AA5 5 ILE A 179 PRO A 181 -1 N VAL A 180 O ARG A 192 SHEET 1 AA6 3 THR A 202 GLN A 203 0 SHEET 2 AA6 3 MET A 434 TYR A 435 1 O TYR A 435 N THR A 202 SHEET 3 AA6 3 ILE A 423 ILE A 424 -1 N ILE A 424 O MET A 434 SHEET 1 AA712 LEU A 259 LEU A 261 0 SHEET 2 AA712 VAL A 271 ARG A 273 0 SHEET 3 AA712 ILE A 284 ARG A 308 -1 O HIS A 287 N VAL A 271 SHEET 4 AA712 THR A 316 ILE A 323 -1 O ALA A 319 N LYS A 305 SHEET 5 AA712 HIS A 330 SER A 334 -1 O ASN A 332 N VAL A 295 SHEET 6 AA712 THR A 357 TYR A 361 0 SHEET 7 AA712 HIS A 374 CYS A 378 0 SHEET 8 AA712 GLU A 381 CYS A 385 -1 O PHE A 383 N PHE A 376 SHEET 9 AA712 GLY A 393 TYR A 395 -1 O TYR A 395 N ILE A 358 SHEET 10 AA712 THR A 413 ILE A 420 -1 O ARG A 419 N TYR A 384 SHEET 11 AA712 GLY A 441 ASP A 457 -1 O ILE A 449 N VAL A 292 SHEET 12 AA712 THR A 465 PRO A 470 -1 O ARG A 469 N THR A 455 SHEET 1 AA8 4 GLN C 3 GLN C 6 0 SHEET 2 AA8 4 SER C 17 SER C 25 -1 O LYS C 23 N VAL C 5 SHEET 3 AA8 4 THR C 78 ASN C 84 -1 O LEU C 83 N VAL C 18 SHEET 4 AA8 4 VAL C 68 ASP C 73 -1 N ASP C 73 O THR C 78 SHEET 1 AA9 6 GLU C 10 LYS C 12 0 SHEET 2 AA9 6 THR C 121 VAL C 125 1 O THR C 124 N GLU C 10 SHEET 3 AA9 6 ALA C 92 TRP C 101 -1 N ALA C 92 O VAL C 123 SHEET 4 AA9 6 HIS C 32 GLN C 39 -1 N TYR C 33 O GLY C 99 SHEET 5 AA9 6 PRO C 45 ILE C 51 -1 O GLU C 46 N ARG C 38 SHEET 6 AA9 6 SER C 58 PHE C 60 -1 O ASN C 59 N TRP C 50 SHEET 1 AB1 6 SER D 9 GLY D 12 0 SHEET 2 AB1 6 VAL D 35 GLN D 40 0 SHEET 3 AB1 6 PRO D 46 ILE D 50 -1 O ILE D 50 N TRP D 37 SHEET 4 AB1 6 ASP D 87 ALA D 94 -1 O CYS D 91 N SER D 36 SHEET 5 AB1 6 THR D 98 PHE D 101 -1 O ILE D 100 N SER D 92 SHEET 6 AB1 6 THR D 105 VAL D 109 -1 O THR D 105 N TYR D 88 SHEET 1 AB2 3 ILE D 18 THR D 23 0 SHEET 2 AB2 3 THR D 72 ILE D 77 -1 O ALA D 73 N CYS D 22 SHEET 3 AB2 3 PHE D 64 SER D 69 -1 N SER D 65 O THR D 76 SHEET 1 AB3 3 LEU E 494 PRO E 498 0 SHEET 2 AB3 3 TRP E 35 TYR E 40 -1 N THR E 37 O ALA E 497 SHEET 3 AB3 3 ILE F 603 PRO F 609 -1 O VAL F 608 N VAL E 36 SHEET 1 AB4 4 TRP E 45 GLU E 47 0 SHEET 2 AB4 4 TYR E 486 ILE E 491 -1 O LYS E 490 N LYS E 46 SHEET 3 AB4 4 TYR E 223 CYS E 228 -1 N ALA E 224 O VAL E 489 SHEET 4 AB4 4 VAL E 242 VAL E 245 -1 O SER E 243 N LYS E 227 SHEET 1 AB5 3 VAL E 75 PRO E 76 0 SHEET 2 AB5 3 PHE E 53 SER E 56 1 N CYS E 54 O VAL E 75 SHEET 3 AB5 3 HIS E 216 CYS E 218 -1 O CYS E 218 N PHE E 53 SHEET 1 AB6 2 GLU E 91 ASN E 94 0 SHEET 2 AB6 2 THR E 236 CYS E 239 -1 O CYS E 239 N GLU E 91 SHEET 1 AB7 5 GLU E 167 TYR E 175 0 SHEET 2 AB7 5 MET E 152 THR E 160 -1 N PHE E 157 O GLU E 170 SHEET 3 AB7 5 LEU E 129 ASP E 133 -1 N ILE E 130 O SER E 156 SHEET 4 AB7 5 GLU E 190 LEU E 193 -1 O TYR E 191 N LEU E 129 SHEET 5 AB7 5 ILE E 179 PRO E 181 -1 N VAL E 180 O ARG E 192 SHEET 1 AB8 3 THR E 202 GLN E 203 0 SHEET 2 AB8 3 CYS E 433 TYR E 435 1 O TYR E 435 N THR E 202 SHEET 3 AB8 3 ILE E 423 ASN E 425 -1 N ILE E 424 O MET E 434 SHEET 1 AB912 LEU E 259 LEU E 261 0 SHEET 2 AB912 VAL E 271 ARG E 273 0 SHEET 3 AB912 ILE E 284 ARG E 308 -1 O HIS E 287 N VAL E 271 SHEET 4 AB912 THR E 316 ILE E 323 -1 O PHE E 317 N VAL E 307 SHEET 5 AB912 HIS E 330 SER E 334 -1 O ASN E 332 N VAL E 295 SHEET 6 AB912 THR E 357 TYR E 361 0 SHEET 7 AB912 HIS E 374 CYS E 378 0 SHEET 8 AB912 GLU E 381 CYS E 385 -1 O CYS E 385 N HIS E 374 SHEET 9 AB912 GLY E 393 TYR E 395 -1 O GLY E 393 N TYR E 361 SHEET 10 AB912 THR E 413 LYS E 421 -1 O ARG E 419 N TYR E 384 SHEET 11 AB912 GLY E 441 ASP E 457 -1 O ILE E 449 N VAL E 292 SHEET 12 AB912 THR E 465 PRO E 470 -1 O ARG E 469 N THR E 455 SHEET 1 AC1 4 GLN G 3 GLN G 6 0 SHEET 2 AC1 4 SER G 17 SER G 25 -1 O LYS G 23 N VAL G 5 SHEET 3 AC1 4 THR G 78 ASN G 84 -1 O MET G 81 N VAL G 20 SHEET 4 AC1 4 VAL G 68 ASP G 73 -1 N ASP G 73 O THR G 78 SHEET 1 AC2 6 GLU G 10 LYS G 12 0 SHEET 2 AC2 6 THR G 121 VAL G 125 1 O THR G 124 N GLU G 10 SHEET 3 AC2 6 ALA G 92 TRP G 101 -1 N ALA G 92 O VAL G 123 SHEET 4 AC2 6 HIS G 32 GLN G 39 -1 N TYR G 33 O GLY G 99 SHEET 5 AC2 6 PRO G 45 ILE G 51 -1 O GLU G 46 N ARG G 38 SHEET 6 AC2 6 SER G 58 PHE G 60 -1 O ASN G 59 N TRP G 50 SHEET 1 AC3 6 SER H 9 GLY H 12 0 SHEET 2 AC3 6 VAL H 35 GLN H 40 0 SHEET 3 AC3 6 LYS H 47 ILE H 50 -1 O LYS H 47 N GLN H 39 SHEET 4 AC3 6 ASP H 87 TYR H 93 -1 O TYR H 89 N TYR H 38 SHEET 5 AC3 6 VAL H 99 PHE H 101 -1 O ILE H 100 N SER H 92 SHEET 6 AC3 6 THR H 105 VAL H 109 -1 O THR H 105 N TYR H 88 SHEET 1 AC4 3 ILE H 18 THR H 23 0 SHEET 2 AC4 3 THR H 72 ILE H 77 -1 O ALA H 73 N CYS H 22 SHEET 3 AC4 3 PHE H 64 SER H 69 -1 N SER H 67 O SER H 74 SHEET 1 AC5 3 LEU I 494 PRO I 498 0 SHEET 2 AC5 3 TRP I 35 TYR I 40 -1 N THR I 37 O ALA I 497 SHEET 3 AC5 3 ILE J 603 PRO J 609 -1 O VAL J 608 N VAL I 36 SHEET 1 AC6 4 TRP I 45 GLU I 47 0 SHEET 2 AC6 4 TYR I 486 ILE I 491 -1 O LYS I 490 N LYS I 46 SHEET 3 AC6 4 TYR I 223 CYS I 228 -1 N ALA I 224 O VAL I 489 SHEET 4 AC6 4 VAL I 242 VAL I 245 -1 O SER I 243 N LYS I 227 SHEET 1 AC7 2 PHE I 53 ALA I 55 0 SHEET 2 AC7 2 HIS I 216 CYS I 218 -1 O CYS I 218 N PHE I 53 SHEET 1 AC8 2 GLU I 91 ASN I 94 0 SHEET 2 AC8 2 THR I 236 CYS I 239 -1 O CYS I 239 N GLU I 91 SHEET 1 AC9 5 GLU I 167 TYR I 175 0 SHEET 2 AC9 5 MET I 152 THR I 160 -1 N PHE I 157 O GLU I 170 SHEET 3 AC9 5 LEU I 129 ASP I 133 -1 N ILE I 130 O SER I 156 SHEET 4 AC9 5 GLU I 190 LEU I 193 -1 O TYR I 191 N LEU I 129 SHEET 5 AC9 5 ILE I 179 PRO I 181 -1 N VAL I 180 O ARG I 192 SHEET 1 AD1 3 CYS I 201 GLN I 203 0 SHEET 2 AD1 3 CYS I 433 TYR I 435 1 O CYS I 433 N THR I 202 SHEET 3 AD1 3 ILE I 423 ILE I 424 -1 N ILE I 424 O MET I 434 SHEET 1 AD211 LEU I 259 LEU I 261 0 SHEET 2 AD211 VAL I 271 ARG I 273 0 SHEET 3 AD211 ILE I 284 ILE I 309 -1 O HIS I 287 N VAL I 271 SHEET 4 AD211 GLN I 315 ILE I 323 -1 O PHE I 317 N VAL I 307 SHEET 5 AD211 HIS I 330 SER I 334 -1 O ASN I 332 N VAL I 295 SHEET 6 AD211 THR I 357 TYR I 361 0 SHEET 7 AD211 HIS I 374 CYS I 378 0 SHEET 8 AD211 GLU I 381 CYS I 385 -1 O PHE I 383 N PHE I 376 SHEET 9 AD211 THR I 413 ILE I 420 -1 O ARG I 419 N TYR I 384 SHEET 10 AD211 GLY I 441 GLY I 458 -1 O LEU I 452 N VAL I 286 SHEET 11 AD211 THR I 465 PRO I 470 -1 O THR I 467 N ASP I 457 SHEET 1 AD3 4 GLN K 3 GLN K 6 0 SHEET 2 AD3 4 SER K 17 SER K 25 -1 O LYS K 23 N VAL K 5 SHEET 3 AD3 4 THR K 78 ASN K 84 -1 O MET K 81 N VAL K 20 SHEET 4 AD3 4 VAL K 68 ASP K 73 -1 N ASP K 73 O THR K 78 SHEET 1 AD4 7 GLU K 10 LYS K 12 0 SHEET 2 AD4 7 HIS K 32 GLN K 39 0 SHEET 3 AD4 7 PRO K 45 ILE K 51 -1 O GLU K 46 N ARG K 38 SHEET 4 AD4 7 SER K 58 PHE K 60 -1 O ASN K 59 N TRP K 50 SHEET 5 AD4 7 ALA K 92 TRP K 101 -1 O GLY K 99 N TYR K 33 SHEET 6 AD4 7 TYR K 116 TRP K 117 -1 O TYR K 116 N THR K 98 SHEET 7 AD4 7 THR K 121 VAL K 125 -1 O VAL K 123 N ALA K 92 SHEET 1 AD5 6 SER L 9 GLY L 12 0 SHEET 2 AD5 6 VAL L 35 GLN L 40 0 SHEET 3 AD5 6 PRO L 46 ILE L 50 -1 O LYS L 47 N GLN L 39 SHEET 4 AD5 6 ASP L 87 GLY L 95 -1 O CYS L 91 N SER L 36 SHEET 5 AD5 6 THR L 98 PHE L 101 -1 O THR L 98 N ALA L 94 SHEET 6 AD5 6 THR L 105 VAL L 109 -1 O THR L 105 N TYR L 88 SHEET 1 AD6 3 ILE L 18 THR L 23 0 SHEET 2 AD6 3 THR L 72 ILE L 77 -1 O ALA L 73 N CYS L 22 SHEET 3 AD6 3 PHE L 64 SER L 69 -1 N SER L 65 O THR L 76 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.03 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.03 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.03 SSBOND 4 CYS A 131 CYS A 155 1555 1555 2.03 SSBOND 5 CYS A 201 CYS A 433 1555 1555 2.03 SSBOND 6 CYS A 218 CYS A 247 1555 1555 2.03 SSBOND 7 CYS A 228 CYS A 239 1555 1555 2.03 SSBOND 8 CYS A 296 CYS A 331 1555 1555 2.02 SSBOND 9 CYS A 378 CYS A 445 1555 1555 2.03 SSBOND 10 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 11 CYS B 598 CYS B 604 1555 1555 2.03 SSBOND 12 CYS C 22 CYS C 96 1555 1555 2.04 SSBOND 13 CYS D 22 CYS D 90 1555 1555 2.02 SSBOND 14 CYS E 54 CYS E 74 1555 1555 2.03 SSBOND 15 CYS E 119 CYS E 205 1555 1555 2.03 SSBOND 16 CYS E 126 CYS E 196 1555 1555 2.03 SSBOND 17 CYS E 131 CYS E 155 1555 1555 2.03 SSBOND 18 CYS E 201 CYS E 433 1555 1555 2.03 SSBOND 19 CYS E 218 CYS E 247 1555 1555 2.03 SSBOND 20 CYS E 228 CYS E 239 1555 1555 2.03 SSBOND 21 CYS E 296 CYS E 331 1555 1555 2.03 SSBOND 22 CYS E 378 CYS E 445 1555 1555 2.03 SSBOND 23 CYS E 385 CYS E 418 1555 1555 2.03 SSBOND 24 CYS F 598 CYS F 604 1555 1555 2.03 SSBOND 25 CYS G 22 CYS G 96 1555 1555 2.04 SSBOND 26 CYS H 22 CYS H 90 1555 1555 2.03 SSBOND 27 CYS I 54 CYS I 74 1555 1555 2.03 SSBOND 28 CYS I 119 CYS I 205 1555 1555 2.03 SSBOND 29 CYS I 126 CYS I 196 1555 1555 2.03 SSBOND 30 CYS I 131 CYS I 155 1555 1555 2.03 SSBOND 31 CYS I 201 CYS I 433 1555 1555 2.03 SSBOND 32 CYS I 218 CYS I 247 1555 1555 2.03 SSBOND 33 CYS I 228 CYS I 239 1555 1555 2.03 SSBOND 34 CYS I 296 CYS I 331 1555 1555 2.02 SSBOND 35 CYS I 378 CYS I 445 1555 1555 2.04 SSBOND 36 CYS I 385 CYS I 418 1555 1555 2.03 SSBOND 37 CYS J 598 CYS J 604 1555 1555 2.03 SSBOND 38 CYS K 22 CYS K 96 1555 1555 2.04 SSBOND 39 CYS L 22 CYS L 90 1555 1555 2.03 LINK ND2 ASN A 154 C1 NAG M 1 1555 1555 1.43 LINK ND2 ASN A 158 C1 NAG h 1 1555 1555 1.43 LINK ND2 ASN A 197 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A 703 1555 1555 1.45 LINK ND2 ASN A 241 C1 NAG f 1 1555 1555 1.43 LINK ND2 ASN A 276 C1 NAG m 1 1555 1555 1.44 LINK ND2 ASN A 301 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN A 332 C1 NAG g 1 1555 1555 1.43 LINK ND2 ASN A 339 C1 NAG n 1 1555 1555 1.44 LINK ND2 ASN A 355 C1 NAG A 701 1555 1555 1.44 LINK ND2 ASN A 362 C1 NAG l 1 1555 1555 1.43 LINK ND2 ASN A 386 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN A 392 C1 NAG e 1 1555 1555 1.44 LINK ND2 ASN A 396 C1 NAG A 702 1555 1555 1.44 LINK ND2 ASN A 442 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN A 448 C1 NAG j 1 1555 1555 1.43 LINK ND2 ASN E 154 C1 NAG N 1 1555 1555 1.43 LINK ND2 ASN E 158 C1 NAG V 1 1555 1555 1.43 LINK ND2 ASN E 197 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN E 234 C1 NAG E 702 1555 1555 1.46 LINK ND2 ASN E 241 C1 NAG T 1 1555 1555 1.43 LINK ND2 ASN E 262 C1 NAG W 1 1555 1555 1.43 LINK ND2 ASN E 276 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN E 301 C1 NAG Q 1 1555 1555 1.43 LINK ND2 ASN E 332 C1 NAG U 1 1555 1555 1.43 LINK ND2 ASN E 339 C1 NAG E 703 1555 1555 1.45 LINK ND2 ASN E 355 C1 NAG E 701 1555 1555 1.43 LINK ND2 ASN E 362 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN E 386 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN E 392 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN E 396 C1 NAG E 704 1555 1555 1.44 LINK ND2 ASN E 442 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN E 448 C1 NAG X 1 1555 1555 1.43 LINK ND2 ASN I 154 C1 NAG O 1 1555 1555 1.43 LINK ND2 ASN I 158 C1 NAG u 1 1555 1555 1.43 LINK ND2 ASN I 197 C1 NAG q 1 1555 1555 1.44 LINK ND2 ASN I 234 C1 NAG I 702 1555 1555 1.44 LINK ND2 ASN I 241 C1 NAG s 1 1555 1555 1.43 LINK ND2 ASN I 301 C1 NAG p 1 1555 1555 1.43 LINK ND2 ASN I 332 C1 NAG t 1 1555 1555 1.43 LINK ND2 ASN I 355 C1 NAG I 701 1555 1555 1.43 LINK ND2 ASN I 362 C1 NAG y 1 1555 1555 1.44 LINK ND2 ASN I 386 C1 NAG x 1 1555 1555 1.44 LINK ND2 ASN I 392 C1 NAG r 1 1555 1555 1.43 LINK ND2 ASN I 442 C1 NAG o 1 1555 1555 1.44 LINK ND2 ASN I 448 C1 NAG w 1 1555 1555 1.43 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG N 2 C1 BMA N 3 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.44 LINK O3 BMA O 3 C1 MAN O 4 1555 1555 1.45 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.45 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG Q 2 C1 BMA Q 3 1555 1555 1.45 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG R 2 C1 BMA R 3 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.45 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.44 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.44 LINK O6 BMA U 3 C1 MAN U 7 1555 1555 1.44 LINK O2 MAN U 4 C1 MAN U 5 1555 1555 1.43 LINK O2 MAN U 5 C1 MAN U 6 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.45 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG W 2 C1 BMA W 3 1555 1555 1.44 LINK O3 BMA W 3 C1 MAN W 4 1555 1555 1.44 LINK O6 BMA W 3 C1 MAN W 5 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG X 2 C1 NAG X 3 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.45 LINK O4 NAG Y 2 C1 BMA Y 3 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.45 LINK O4 NAG Z 2 C1 BMA Z 3 1555 1555 1.45 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.44 LINK O4 NAG b 2 C1 BMA b 3 1555 1555 1.45 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.45 LINK O4 NAG c 2 C1 BMA c 3 1555 1555 1.45 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.45 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.44 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.45 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.44 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.45 LINK O4 NAG g 2 C1 BMA g 3 1555 1555 1.44 LINK O3 BMA g 3 C1 MAN g 4 1555 1555 1.44 LINK O6 BMA g 3 C1 MAN g 7 1555 1555 1.44 LINK O2 MAN g 4 C1 MAN g 5 1555 1555 1.43 LINK O2 MAN g 5 C1 MAN g 6 1555 1555 1.44 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.44 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.44 LINK O4 NAG i 2 C1 BMA i 3 1555 1555 1.44 LINK O3 BMA i 3 C1 MAN i 4 1555 1555 1.44 LINK O6 BMA i 3 C1 MAN i 5 1555 1555 1.44 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.44 LINK O4 NAG j 2 C1 NAG j 3 1555 1555 1.44 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.45 LINK O4 NAG k 2 C1 BMA k 3 1555 1555 1.45 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.45 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.47 LINK O4 NAG m 2 C1 BMA m 3 1555 1555 1.44 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.44 LINK O4 NAG n 2 C1 BMA n 3 1555 1555 1.44 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.44 LINK O4 NAG o 2 C1 BMA o 3 1555 1555 1.45 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.44 LINK O4 NAG p 2 C1 BMA p 3 1555 1555 1.45 LINK O4 NAG q 1 C1 NAG q 2 1555 1555 1.44 LINK O4 NAG r 1 C1 NAG r 2 1555 1555 1.45 LINK O4 NAG s 1 C1 NAG s 2 1555 1555 1.44 LINK O4 NAG t 1 C1 NAG t 2 1555 1555 1.45 LINK O4 NAG t 2 C1 BMA t 3 1555 1555 1.44 LINK O3 BMA t 3 C1 MAN t 4 1555 1555 1.44 LINK O6 BMA t 3 C1 MAN t 7 1555 1555 1.44 LINK O2 MAN t 4 C1 MAN t 5 1555 1555 1.43 LINK O2 MAN t 5 C1 MAN t 6 1555 1555 1.44 LINK O4 NAG u 1 C1 NAG u 2 1555 1555 1.44 LINK O4 NAG v 1 C1 NAG v 2 1555 1555 1.43 LINK O4 NAG v 2 C1 BMA v 3 1555 1555 1.44 LINK O3 BMA v 3 C1 MAN v 4 1555 1555 1.44 LINK O6 BMA v 3 C1 MAN v 5 1555 1555 1.44 LINK O4 NAG w 1 C1 NAG w 2 1555 1555 1.44 LINK O4 NAG w 2 C1 NAG w 3 1555 1555 1.44 LINK O4 NAG x 1 C1 NAG x 2 1555 1555 1.45 LINK O4 NAG x 2 C1 BMA x 3 1555 1555 1.45 LINK O4 NAG y 1 C1 NAG y 2 1555 1555 1.45 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000