HEADER IMMUNE SYSTEM 05-AUG-22 8DYT TITLE CRYO-EM STRUCTURE OF 227 FAB IN COMPLEX WITH (NPNA)8 PEPTIDE COMPND MOL_ID: 1; COMPND 2 MOLECULE: CIRCUMSPOROZOITE PROTEIN; COMPND 3 CHAIN: I, J; COMPND 4 SYNONYM: (NPNA)8 PEPTIDE; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: 227 FAB LIGHT CHAIN; COMPND 8 CHAIN: L, B, D, F, N, P, R, T; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: 227 FAB HEAVY CHAIN; COMPND 12 CHAIN: H, A, C, E, M, O, Q, S; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: PLASMODIUM FALCIPARUM 3D7; SOURCE 3 ORGANISM_TAXID: 36329; SOURCE 4 GENE: CSP; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_COMMON: HUMAN; SOURCE 10 ORGANISM_TAXID: 9606; SOURCE 11 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 12 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 14 MOL_ID: 3; SOURCE 15 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 16 ORGANISM_COMMON: HUMAN; SOURCE 17 ORGANISM_TAXID: 9606; SOURCE 18 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 19 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 10029 KEYWDS MALARIA ANTIBODY, PFCSP, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR G.M.MARTIN,A.B.WARD REVDAT 1 02-AUG-23 8DYT 0 JRNL AUTH G.M.MARTIN,A.B.WARD JRNL TITL SPECTRUM OF PFCSP-ANTIBODY CRYO-EM STRUCTURES AND THE ROLE JRNL TITL 2 OF HOMOTYPIC INTERACTIONS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.30 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.300 REMARK 3 NUMBER OF PARTICLES : 70120 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8DYT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 08-AUG-22. REMARK 100 THE DEPOSITION ID IS D_1000267572. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : 227 FAB - (NPNA)8 COMPLEX; REMARK 245 CIRCUMSPOROZOITE PROTEIN; 227 REMARK 245 FAB LIGHT CHAIN, 227 FAB HEAVY REMARK 245 CHAIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TECNAI ARCTICA REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: I, J, L, H, B, A, D, C, F, E, REMARK 350 AND CHAINS: N, M, P, O, R, Q, T, S REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLN L 1 REMARK 465 SER L 2 REMARK 465 LEU L 107 REMARK 465 GLY L 108 REMARK 465 GLN L 109 REMARK 465 PRO L 110 REMARK 465 LYS L 111 REMARK 465 ALA L 112 REMARK 465 ASN L 113 REMARK 465 PRO L 114 REMARK 465 THR L 115 REMARK 465 VAL L 116 REMARK 465 THR L 117 REMARK 465 LEU L 118 REMARK 465 PHE L 119 REMARK 465 PRO L 120 REMARK 465 PRO L 121 REMARK 465 SER L 122 REMARK 465 SER L 123 REMARK 465 GLU L 124 REMARK 465 GLU L 125 REMARK 465 LEU L 126 REMARK 465 GLN L 127 REMARK 465 ALA L 128 REMARK 465 ASN L 129 REMARK 465 LYS L 130 REMARK 465 ALA L 131 REMARK 465 THR L 132 REMARK 465 LEU L 133 REMARK 465 VAL L 134 REMARK 465 CYS L 135 REMARK 465 LEU L 136 REMARK 465 ILE L 137 REMARK 465 SER L 138 REMARK 465 ASP L 139 REMARK 465 PHE L 140 REMARK 465 TYR L 141 REMARK 465 PRO L 142 REMARK 465 GLY L 143 REMARK 465 ALA L 144 REMARK 465 VAL L 145 REMARK 465 THR L 146 REMARK 465 VAL L 147 REMARK 465 ALA L 148 REMARK 465 TRP L 149 REMARK 465 LYS L 150 REMARK 465 ALA L 151 REMARK 465 ASP L 152 REMARK 465 GLY L 153 REMARK 465 SER L 154 REMARK 465 PRO L 155 REMARK 465 VAL L 156 REMARK 465 LYS L 157 REMARK 465 ALA L 158 REMARK 465 GLY L 159 REMARK 465 VAL L 160 REMARK 465 GLU L 161 REMARK 465 THR L 162 REMARK 465 THR L 163 REMARK 465 LYS L 164 REMARK 465 PRO L 165 REMARK 465 SER L 166 REMARK 465 LYS L 167 REMARK 465 GLN L 168 REMARK 465 SER L 169 REMARK 465 ASN L 170 REMARK 465 ASN L 171 REMARK 465 LYS L 172 REMARK 465 TYR L 173 REMARK 465 ALA L 174 REMARK 465 ALA L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 TYR L 178 REMARK 465 LEU L 179 REMARK 465 SER L 180 REMARK 465 LEU L 181 REMARK 465 THR L 182 REMARK 465 PRO L 183 REMARK 465 GLU L 184 REMARK 465 GLN L 185 REMARK 465 TRP L 186 REMARK 465 LYS L 187 REMARK 465 SER L 188 REMARK 465 HIS L 189 REMARK 465 ARG L 190 REMARK 465 SER L 191 REMARK 465 TYR L 192 REMARK 465 SER L 193 REMARK 465 CYS L 194 REMARK 465 GLN L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLU L 199 REMARK 465 GLY L 200 REMARK 465 SER L 201 REMARK 465 THR L 202 REMARK 465 VAL L 203 REMARK 465 GLU L 204 REMARK 465 LYS L 205 REMARK 465 THR L 206 REMARK 465 VAL L 207 REMARK 465 ALA L 208 REMARK 465 PRO L 209 REMARK 465 THR L 210 REMARK 465 GLU L 211 REMARK 465 CYS L 212 REMARK 465 SER L 213 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 LYS H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 THR H 219 REMARK 465 HIS H 220 REMARK 465 THR H 221 REMARK 465 CYS H 222 REMARK 465 PRO H 223 REMARK 465 PRO H 224 REMARK 465 CYS H 225 REMARK 465 PRO H 226 REMARK 465 ALA H 227 REMARK 465 PRO H 228 REMARK 465 GLU H 229 REMARK 465 LEU H 230 REMARK 465 LEU H 231 REMARK 465 GLY H 232 REMARK 465 GLY H 233 REMARK 465 PRO H 234 REMARK 465 SER H 235 REMARK 465 VAL H 236 REMARK 465 PHE H 237 REMARK 465 LEU H 238 REMARK 465 PHE H 239 REMARK 465 PRO H 240 REMARK 465 PRO H 241 REMARK 465 LYS H 242 REMARK 465 PRO H 243 REMARK 465 LYS H 244 REMARK 465 ASP H 245 REMARK 465 THR H 246 REMARK 465 LEU H 247 REMARK 465 MET H 248 REMARK 465 ILE H 249 REMARK 465 SER H 250 REMARK 465 ARG H 251 REMARK 465 THR H 252 REMARK 465 PRO H 253 REMARK 465 GLU H 254 REMARK 465 VAL H 255 REMARK 465 THR H 256 REMARK 465 CYS H 257 REMARK 465 VAL H 258 REMARK 465 VAL H 259 REMARK 465 VAL H 260 REMARK 465 ASP H 261 REMARK 465 VAL H 262 REMARK 465 SER H 263 REMARK 465 HIS H 264 REMARK 465 GLU H 265 REMARK 465 ASP H 266 REMARK 465 PRO H 267 REMARK 465 GLU H 268 REMARK 465 VAL H 269 REMARK 465 LYS H 270 REMARK 465 PHE H 271 REMARK 465 ASN H 272 REMARK 465 TRP H 273 REMARK 465 TYR H 274 REMARK 465 VAL H 275 REMARK 465 ASP H 276 REMARK 465 GLY H 277 REMARK 465 VAL H 278 REMARK 465 GLU H 279 REMARK 465 VAL H 280 REMARK 465 HIS H 281 REMARK 465 ASN H 282 REMARK 465 ALA H 283 REMARK 465 LYS H 284 REMARK 465 THR H 285 REMARK 465 LYS H 286 REMARK 465 PRO H 287 REMARK 465 ARG H 288 REMARK 465 GLU H 289 REMARK 465 GLU H 290 REMARK 465 GLN H 291 REMARK 465 TYR H 292 REMARK 465 ASN H 293 REMARK 465 SER H 294 REMARK 465 THR H 295 REMARK 465 TYR H 296 REMARK 465 ARG H 297 REMARK 465 VAL H 298 REMARK 465 VAL H 299 REMARK 465 SER H 300 REMARK 465 VAL H 301 REMARK 465 LEU H 302 REMARK 465 THR H 303 REMARK 465 VAL H 304 REMARK 465 LEU H 305 REMARK 465 HIS H 306 REMARK 465 GLN H 307 REMARK 465 ASP H 308 REMARK 465 TRP H 309 REMARK 465 LEU H 310 REMARK 465 ASN H 311 REMARK 465 GLY H 312 REMARK 465 LYS H 313 REMARK 465 GLU H 314 REMARK 465 TYR H 315 REMARK 465 LYS H 316 REMARK 465 CYS H 317 REMARK 465 LYS H 318 REMARK 465 VAL H 319 REMARK 465 SER H 320 REMARK 465 ASN H 321 REMARK 465 LYS H 322 REMARK 465 ALA H 323 REMARK 465 LEU H 324 REMARK 465 PRO H 325 REMARK 465 ALA H 326 REMARK 465 PRO H 327 REMARK 465 ILE H 328 REMARK 465 GLU H 329 REMARK 465 LYS H 330 REMARK 465 THR H 331 REMARK 465 ILE H 332 REMARK 465 SER H 333 REMARK 465 LYS H 334 REMARK 465 ALA H 335 REMARK 465 LYS H 336 REMARK 465 GLY H 337 REMARK 465 GLN H 338 REMARK 465 PRO H 339 REMARK 465 ARG H 340 REMARK 465 GLU H 341 REMARK 465 PRO H 342 REMARK 465 GLN H 343 REMARK 465 VAL H 344 REMARK 465 TYR H 345 REMARK 465 THR H 346 REMARK 465 LEU H 347 REMARK 465 PRO H 348 REMARK 465 PRO H 349 REMARK 465 SER H 350 REMARK 465 ARG H 351 REMARK 465 ASP H 352 REMARK 465 GLU H 353 REMARK 465 LEU H 354 REMARK 465 THR H 355 REMARK 465 LYS H 356 REMARK 465 ASN H 357 REMARK 465 GLN H 358 REMARK 465 VAL H 359 REMARK 465 SER H 360 REMARK 465 LEU H 361 REMARK 465 THR H 362 REMARK 465 CYS H 363 REMARK 465 LEU H 364 REMARK 465 VAL H 365 REMARK 465 LYS H 366 REMARK 465 GLY H 367 REMARK 465 PHE H 368 REMARK 465 TYR H 369 REMARK 465 PRO H 370 REMARK 465 SER H 371 REMARK 465 ASP H 372 REMARK 465 ILE H 373 REMARK 465 ALA H 374 REMARK 465 VAL H 375 REMARK 465 GLU H 376 REMARK 465 TRP H 377 REMARK 465 GLU H 378 REMARK 465 SER H 379 REMARK 465 ASN H 380 REMARK 465 GLY H 381 REMARK 465 GLN H 382 REMARK 465 PRO H 383 REMARK 465 GLU H 384 REMARK 465 ASN H 385 REMARK 465 ASN H 386 REMARK 465 TYR H 387 REMARK 465 LYS H 388 REMARK 465 THR H 389 REMARK 465 THR H 390 REMARK 465 PRO H 391 REMARK 465 PRO H 392 REMARK 465 VAL H 393 REMARK 465 LEU H 394 REMARK 465 ASP H 395 REMARK 465 SER H 396 REMARK 465 ASP H 397 REMARK 465 GLY H 398 REMARK 465 SER H 399 REMARK 465 PHE H 400 REMARK 465 PHE H 401 REMARK 465 LEU H 402 REMARK 465 TYR H 403 REMARK 465 SER H 404 REMARK 465 LYS H 405 REMARK 465 LEU H 406 REMARK 465 THR H 407 REMARK 465 VAL H 408 REMARK 465 ASP H 409 REMARK 465 LYS H 410 REMARK 465 SER H 411 REMARK 465 ARG H 412 REMARK 465 TRP H 413 REMARK 465 GLN H 414 REMARK 465 GLN H 415 REMARK 465 GLY H 416 REMARK 465 ASN H 417 REMARK 465 VAL H 418 REMARK 465 PHE H 419 REMARK 465 SER H 420 REMARK 465 CYS H 421 REMARK 465 SER H 422 REMARK 465 VAL H 423 REMARK 465 MET H 424 REMARK 465 HIS H 425 REMARK 465 GLU H 426 REMARK 465 ALA H 427 REMARK 465 LEU H 428 REMARK 465 HIS H 429 REMARK 465 ASN H 430 REMARK 465 HIS H 431 REMARK 465 TYR H 432 REMARK 465 THR H 433 REMARK 465 GLN H 434 REMARK 465 LYS H 435 REMARK 465 SER H 436 REMARK 465 LEU H 437 REMARK 465 SER H 438 REMARK 465 LEU H 439 REMARK 465 SER H 440 REMARK 465 PRO H 441 REMARK 465 GLY H 442 REMARK 465 GLN B 1 REMARK 465 SER B 2 REMARK 465 LEU B 107 REMARK 465 GLY B 108 REMARK 465 GLN B 109 REMARK 465 PRO B 110 REMARK 465 LYS B 111 REMARK 465 ALA B 112 REMARK 465 ASN B 113 REMARK 465 PRO B 114 REMARK 465 THR B 115 REMARK 465 VAL B 116 REMARK 465 THR B 117 REMARK 465 LEU B 118 REMARK 465 PHE B 119 REMARK 465 PRO B 120 REMARK 465 PRO B 121 REMARK 465 SER B 122 REMARK 465 SER B 123 REMARK 465 GLU B 124 REMARK 465 GLU B 125 REMARK 465 LEU B 126 REMARK 465 GLN B 127 REMARK 465 ALA B 128 REMARK 465 ASN B 129 REMARK 465 LYS B 130 REMARK 465 ALA B 131 REMARK 465 THR B 132 REMARK 465 LEU B 133 REMARK 465 VAL B 134 REMARK 465 CYS B 135 REMARK 465 LEU B 136 REMARK 465 ILE B 137 REMARK 465 SER B 138 REMARK 465 ASP B 139 REMARK 465 PHE B 140 REMARK 465 TYR B 141 REMARK 465 PRO B 142 REMARK 465 GLY B 143 REMARK 465 ALA B 144 REMARK 465 VAL B 145 REMARK 465 THR B 146 REMARK 465 VAL B 147 REMARK 465 ALA B 148 REMARK 465 TRP B 149 REMARK 465 LYS B 150 REMARK 465 ALA B 151 REMARK 465 ASP B 152 REMARK 465 GLY B 153 REMARK 465 SER B 154 REMARK 465 PRO B 155 REMARK 465 VAL B 156 REMARK 465 LYS B 157 REMARK 465 ALA B 158 REMARK 465 GLY B 159 REMARK 465 VAL B 160 REMARK 465 GLU B 161 REMARK 465 THR B 162 REMARK 465 THR B 163 REMARK 465 LYS B 164 REMARK 465 PRO B 165 REMARK 465 SER B 166 REMARK 465 LYS B 167 REMARK 465 GLN B 168 REMARK 465 SER B 169 REMARK 465 ASN B 170 REMARK 465 ASN B 171 REMARK 465 LYS B 172 REMARK 465 TYR B 173 REMARK 465 ALA B 174 REMARK 465 ALA B 175 REMARK 465 SER B 176 REMARK 465 SER B 177 REMARK 465 TYR B 178 REMARK 465 LEU B 179 REMARK 465 SER B 180 REMARK 465 LEU B 181 REMARK 465 THR B 182 REMARK 465 PRO B 183 REMARK 465 GLU B 184 REMARK 465 GLN B 185 REMARK 465 TRP B 186 REMARK 465 LYS B 187 REMARK 465 SER B 188 REMARK 465 HIS B 189 REMARK 465 ARG B 190 REMARK 465 SER B 191 REMARK 465 TYR B 192 REMARK 465 SER B 193 REMARK 465 CYS B 194 REMARK 465 GLN B 195 REMARK 465 VAL B 196 REMARK 465 THR B 197 REMARK 465 HIS B 198 REMARK 465 GLU B 199 REMARK 465 GLY B 200 REMARK 465 SER B 201 REMARK 465 THR B 202 REMARK 465 VAL B 203 REMARK 465 GLU B 204 REMARK 465 LYS B 205 REMARK 465 THR B 206 REMARK 465 VAL B 207 REMARK 465 ALA B 208 REMARK 465 PRO B 209 REMARK 465 THR B 210 REMARK 465 GLU B 211 REMARK 465 CYS B 212 REMARK 465 SER B 213 REMARK 465 ALA A 114 REMARK 465 SER A 115 REMARK 465 THR A 116 REMARK 465 LYS A 117 REMARK 465 GLY A 118 REMARK 465 PRO A 119 REMARK 465 SER A 120 REMARK 465 VAL A 121 REMARK 465 PHE A 122 REMARK 465 PRO A 123 REMARK 465 LEU A 124 REMARK 465 ALA A 125 REMARK 465 PRO A 126 REMARK 465 SER A 127 REMARK 465 SER A 128 REMARK 465 LYS A 129 REMARK 465 SER A 130 REMARK 465 THR A 131 REMARK 465 SER A 132 REMARK 465 GLY A 133 REMARK 465 GLY A 134 REMARK 465 THR A 135 REMARK 465 ALA A 136 REMARK 465 ALA A 137 REMARK 465 LEU A 138 REMARK 465 GLY A 139 REMARK 465 CYS A 140 REMARK 465 LEU A 141 REMARK 465 VAL A 142 REMARK 465 LYS A 143 REMARK 465 ASP A 144 REMARK 465 TYR A 145 REMARK 465 PHE A 146 REMARK 465 PRO A 147 REMARK 465 GLU A 148 REMARK 465 PRO A 149 REMARK 465 VAL A 150 REMARK 465 THR A 151 REMARK 465 VAL A 152 REMARK 465 SER A 153 REMARK 465 TRP A 154 REMARK 465 ASN A 155 REMARK 465 SER A 156 REMARK 465 GLY A 157 REMARK 465 ALA A 158 REMARK 465 LEU A 159 REMARK 465 THR A 160 REMARK 465 SER A 161 REMARK 465 GLY A 162 REMARK 465 VAL A 163 REMARK 465 HIS A 164 REMARK 465 THR A 165 REMARK 465 PHE A 166 REMARK 465 PRO A 167 REMARK 465 ALA A 168 REMARK 465 VAL A 169 REMARK 465 LEU A 170 REMARK 465 GLN A 171 REMARK 465 SER A 172 REMARK 465 SER A 173 REMARK 465 GLY A 174 REMARK 465 LEU A 175 REMARK 465 TYR A 176 REMARK 465 SER A 177 REMARK 465 LEU A 178 REMARK 465 SER A 179 REMARK 465 SER A 180 REMARK 465 VAL A 181 REMARK 465 VAL A 182 REMARK 465 THR A 183 REMARK 465 VAL A 184 REMARK 465 PRO A 185 REMARK 465 SER A 186 REMARK 465 SER A 187 REMARK 465 SER A 188 REMARK 465 LEU A 189 REMARK 465 GLY A 190 REMARK 465 THR A 191 REMARK 465 GLN A 192 REMARK 465 THR A 193 REMARK 465 TYR A 194 REMARK 465 ILE A 195 REMARK 465 CYS A 196 REMARK 465 ASN A 197 REMARK 465 VAL A 198 REMARK 465 ASN A 199 REMARK 465 HIS A 200 REMARK 465 LYS A 201 REMARK 465 PRO A 202 REMARK 465 SER A 203 REMARK 465 ASN A 204 REMARK 465 THR A 205 REMARK 465 LYS A 206 REMARK 465 VAL A 207 REMARK 465 ASP A 208 REMARK 465 LYS A 209 REMARK 465 LYS A 210 REMARK 465 VAL A 211 REMARK 465 GLU A 212 REMARK 465 PRO A 213 REMARK 465 LYS A 214 REMARK 465 SER A 215 REMARK 465 CYS A 216 REMARK 465 ASP A 217 REMARK 465 LYS A 218 REMARK 465 THR A 219 REMARK 465 HIS A 220 REMARK 465 THR A 221 REMARK 465 CYS A 222 REMARK 465 PRO A 223 REMARK 465 PRO A 224 REMARK 465 CYS A 225 REMARK 465 PRO A 226 REMARK 465 ALA A 227 REMARK 465 PRO A 228 REMARK 465 GLU A 229 REMARK 465 LEU A 230 REMARK 465 LEU A 231 REMARK 465 GLY A 232 REMARK 465 GLY A 233 REMARK 465 PRO A 234 REMARK 465 SER A 235 REMARK 465 VAL A 236 REMARK 465 PHE A 237 REMARK 465 LEU A 238 REMARK 465 PHE A 239 REMARK 465 PRO A 240 REMARK 465 PRO A 241 REMARK 465 LYS A 242 REMARK 465 PRO A 243 REMARK 465 LYS A 244 REMARK 465 ASP A 245 REMARK 465 THR A 246 REMARK 465 LEU A 247 REMARK 465 MET A 248 REMARK 465 ILE A 249 REMARK 465 SER A 250 REMARK 465 ARG A 251 REMARK 465 THR A 252 REMARK 465 PRO A 253 REMARK 465 GLU A 254 REMARK 465 VAL A 255 REMARK 465 THR A 256 REMARK 465 CYS A 257 REMARK 465 VAL A 258 REMARK 465 VAL A 259 REMARK 465 VAL A 260 REMARK 465 ASP A 261 REMARK 465 VAL A 262 REMARK 465 SER A 263 REMARK 465 HIS A 264 REMARK 465 GLU A 265 REMARK 465 ASP A 266 REMARK 465 PRO A 267 REMARK 465 GLU A 268 REMARK 465 VAL A 269 REMARK 465 LYS A 270 REMARK 465 PHE A 271 REMARK 465 ASN A 272 REMARK 465 TRP A 273 REMARK 465 TYR A 274 REMARK 465 VAL A 275 REMARK 465 ASP A 276 REMARK 465 GLY A 277 REMARK 465 VAL A 278 REMARK 465 GLU A 279 REMARK 465 VAL A 280 REMARK 465 HIS A 281 REMARK 465 ASN A 282 REMARK 465 ALA A 283 REMARK 465 LYS A 284 REMARK 465 THR A 285 REMARK 465 LYS A 286 REMARK 465 PRO A 287 REMARK 465 ARG A 288 REMARK 465 GLU A 289 REMARK 465 GLU A 290 REMARK 465 GLN A 291 REMARK 465 TYR A 292 REMARK 465 ASN A 293 REMARK 465 SER A 294 REMARK 465 THR A 295 REMARK 465 TYR A 296 REMARK 465 ARG A 297 REMARK 465 VAL A 298 REMARK 465 VAL A 299 REMARK 465 SER A 300 REMARK 465 VAL A 301 REMARK 465 LEU A 302 REMARK 465 THR A 303 REMARK 465 VAL A 304 REMARK 465 LEU A 305 REMARK 465 HIS A 306 REMARK 465 GLN A 307 REMARK 465 ASP A 308 REMARK 465 TRP A 309 REMARK 465 LEU A 310 REMARK 465 ASN A 311 REMARK 465 GLY A 312 REMARK 465 LYS A 313 REMARK 465 GLU A 314 REMARK 465 TYR A 315 REMARK 465 LYS A 316 REMARK 465 CYS A 317 REMARK 465 LYS A 318 REMARK 465 VAL A 319 REMARK 465 SER A 320 REMARK 465 ASN A 321 REMARK 465 LYS A 322 REMARK 465 ALA A 323 REMARK 465 LEU A 324 REMARK 465 PRO A 325 REMARK 465 ALA A 326 REMARK 465 PRO A 327 REMARK 465 ILE A 328 REMARK 465 GLU A 329 REMARK 465 LYS A 330 REMARK 465 THR A 331 REMARK 465 ILE A 332 REMARK 465 SER A 333 REMARK 465 LYS A 334 REMARK 465 ALA A 335 REMARK 465 LYS A 336 REMARK 465 GLY A 337 REMARK 465 GLN A 338 REMARK 465 PRO A 339 REMARK 465 ARG A 340 REMARK 465 GLU A 341 REMARK 465 PRO A 342 REMARK 465 GLN A 343 REMARK 465 VAL A 344 REMARK 465 TYR A 345 REMARK 465 THR A 346 REMARK 465 LEU A 347 REMARK 465 PRO A 348 REMARK 465 PRO A 349 REMARK 465 SER A 350 REMARK 465 ARG A 351 REMARK 465 ASP A 352 REMARK 465 GLU A 353 REMARK 465 LEU A 354 REMARK 465 THR A 355 REMARK 465 LYS A 356 REMARK 465 ASN A 357 REMARK 465 GLN A 358 REMARK 465 VAL A 359 REMARK 465 SER A 360 REMARK 465 LEU A 361 REMARK 465 THR A 362 REMARK 465 CYS A 363 REMARK 465 LEU A 364 REMARK 465 VAL A 365 REMARK 465 LYS A 366 REMARK 465 GLY A 367 REMARK 465 PHE A 368 REMARK 465 TYR A 369 REMARK 465 PRO A 370 REMARK 465 SER A 371 REMARK 465 ASP A 372 REMARK 465 ILE A 373 REMARK 465 ALA A 374 REMARK 465 VAL A 375 REMARK 465 GLU A 376 REMARK 465 TRP A 377 REMARK 465 GLU A 378 REMARK 465 SER A 379 REMARK 465 ASN A 380 REMARK 465 GLY A 381 REMARK 465 GLN A 382 REMARK 465 PRO A 383 REMARK 465 GLU A 384 REMARK 465 ASN A 385 REMARK 465 ASN A 386 REMARK 465 TYR A 387 REMARK 465 LYS A 388 REMARK 465 THR A 389 REMARK 465 THR A 390 REMARK 465 PRO A 391 REMARK 465 PRO A 392 REMARK 465 VAL A 393 REMARK 465 LEU A 394 REMARK 465 ASP A 395 REMARK 465 SER A 396 REMARK 465 ASP A 397 REMARK 465 GLY A 398 REMARK 465 SER A 399 REMARK 465 PHE A 400 REMARK 465 PHE A 401 REMARK 465 LEU A 402 REMARK 465 TYR A 403 REMARK 465 SER A 404 REMARK 465 LYS A 405 REMARK 465 LEU A 406 REMARK 465 THR A 407 REMARK 465 VAL A 408 REMARK 465 ASP A 409 REMARK 465 LYS A 410 REMARK 465 SER A 411 REMARK 465 ARG A 412 REMARK 465 TRP A 413 REMARK 465 GLN A 414 REMARK 465 GLN A 415 REMARK 465 GLY A 416 REMARK 465 ASN A 417 REMARK 465 VAL A 418 REMARK 465 PHE A 419 REMARK 465 SER A 420 REMARK 465 CYS A 421 REMARK 465 SER A 422 REMARK 465 VAL A 423 REMARK 465 MET A 424 REMARK 465 HIS A 425 REMARK 465 GLU A 426 REMARK 465 ALA A 427 REMARK 465 LEU A 428 REMARK 465 HIS A 429 REMARK 465 ASN A 430 REMARK 465 HIS A 431 REMARK 465 TYR A 432 REMARK 465 THR A 433 REMARK 465 GLN A 434 REMARK 465 LYS A 435 REMARK 465 SER A 436 REMARK 465 LEU A 437 REMARK 465 SER A 438 REMARK 465 LEU A 439 REMARK 465 SER A 440 REMARK 465 PRO A 441 REMARK 465 GLY A 442 REMARK 465 GLN D 1 REMARK 465 SER D 2 REMARK 465 LEU D 107 REMARK 465 GLY D 108 REMARK 465 GLN D 109 REMARK 465 PRO D 110 REMARK 465 LYS D 111 REMARK 465 ALA D 112 REMARK 465 ASN D 113 REMARK 465 PRO D 114 REMARK 465 THR D 115 REMARK 465 VAL D 116 REMARK 465 THR D 117 REMARK 465 LEU D 118 REMARK 465 PHE D 119 REMARK 465 PRO D 120 REMARK 465 PRO D 121 REMARK 465 SER D 122 REMARK 465 SER D 123 REMARK 465 GLU D 124 REMARK 465 GLU D 125 REMARK 465 LEU D 126 REMARK 465 GLN D 127 REMARK 465 ALA D 128 REMARK 465 ASN D 129 REMARK 465 LYS D 130 REMARK 465 ALA D 131 REMARK 465 THR D 132 REMARK 465 LEU D 133 REMARK 465 VAL D 134 REMARK 465 CYS D 135 REMARK 465 LEU D 136 REMARK 465 ILE D 137 REMARK 465 SER D 138 REMARK 465 ASP D 139 REMARK 465 PHE D 140 REMARK 465 TYR D 141 REMARK 465 PRO D 142 REMARK 465 GLY D 143 REMARK 465 ALA D 144 REMARK 465 VAL D 145 REMARK 465 THR D 146 REMARK 465 VAL D 147 REMARK 465 ALA D 148 REMARK 465 TRP D 149 REMARK 465 LYS D 150 REMARK 465 ALA D 151 REMARK 465 ASP D 152 REMARK 465 GLY D 153 REMARK 465 SER D 154 REMARK 465 PRO D 155 REMARK 465 VAL D 156 REMARK 465 LYS D 157 REMARK 465 ALA D 158 REMARK 465 GLY D 159 REMARK 465 VAL D 160 REMARK 465 GLU D 161 REMARK 465 THR D 162 REMARK 465 THR D 163 REMARK 465 LYS D 164 REMARK 465 PRO D 165 REMARK 465 SER D 166 REMARK 465 LYS D 167 REMARK 465 GLN D 168 REMARK 465 SER D 169 REMARK 465 ASN D 170 REMARK 465 ASN D 171 REMARK 465 LYS D 172 REMARK 465 TYR D 173 REMARK 465 ALA D 174 REMARK 465 ALA D 175 REMARK 465 SER D 176 REMARK 465 SER D 177 REMARK 465 TYR D 178 REMARK 465 LEU D 179 REMARK 465 SER D 180 REMARK 465 LEU D 181 REMARK 465 THR D 182 REMARK 465 PRO D 183 REMARK 465 GLU D 184 REMARK 465 GLN D 185 REMARK 465 TRP D 186 REMARK 465 LYS D 187 REMARK 465 SER D 188 REMARK 465 HIS D 189 REMARK 465 ARG D 190 REMARK 465 SER D 191 REMARK 465 TYR D 192 REMARK 465 SER D 193 REMARK 465 CYS D 194 REMARK 465 GLN D 195 REMARK 465 VAL D 196 REMARK 465 THR D 197 REMARK 465 HIS D 198 REMARK 465 GLU D 199 REMARK 465 GLY D 200 REMARK 465 SER D 201 REMARK 465 THR D 202 REMARK 465 VAL D 203 REMARK 465 GLU D 204 REMARK 465 LYS D 205 REMARK 465 THR D 206 REMARK 465 VAL D 207 REMARK 465 ALA D 208 REMARK 465 PRO D 209 REMARK 465 THR D 210 REMARK 465 GLU D 211 REMARK 465 CYS D 212 REMARK 465 SER D 213 REMARK 465 ALA C 114 REMARK 465 SER C 115 REMARK 465 THR C 116 REMARK 465 LYS C 117 REMARK 465 GLY C 118 REMARK 465 PRO C 119 REMARK 465 SER C 120 REMARK 465 VAL C 121 REMARK 465 PHE C 122 REMARK 465 PRO C 123 REMARK 465 LEU C 124 REMARK 465 ALA C 125 REMARK 465 PRO C 126 REMARK 465 SER C 127 REMARK 465 SER C 128 REMARK 465 LYS C 129 REMARK 465 SER C 130 REMARK 465 THR C 131 REMARK 465 SER C 132 REMARK 465 GLY C 133 REMARK 465 GLY C 134 REMARK 465 THR C 135 REMARK 465 ALA C 136 REMARK 465 ALA C 137 REMARK 465 LEU C 138 REMARK 465 GLY C 139 REMARK 465 CYS C 140 REMARK 465 LEU C 141 REMARK 465 VAL C 142 REMARK 465 LYS C 143 REMARK 465 ASP C 144 REMARK 465 TYR C 145 REMARK 465 PHE C 146 REMARK 465 PRO C 147 REMARK 465 GLU C 148 REMARK 465 PRO C 149 REMARK 465 VAL C 150 REMARK 465 THR C 151 REMARK 465 VAL C 152 REMARK 465 SER C 153 REMARK 465 TRP C 154 REMARK 465 ASN C 155 REMARK 465 SER C 156 REMARK 465 GLY C 157 REMARK 465 ALA C 158 REMARK 465 LEU C 159 REMARK 465 THR C 160 REMARK 465 SER C 161 REMARK 465 GLY C 162 REMARK 465 VAL C 163 REMARK 465 HIS C 164 REMARK 465 THR C 165 REMARK 465 PHE C 166 REMARK 465 PRO C 167 REMARK 465 ALA C 168 REMARK 465 VAL C 169 REMARK 465 LEU C 170 REMARK 465 GLN C 171 REMARK 465 SER C 172 REMARK 465 SER C 173 REMARK 465 GLY C 174 REMARK 465 LEU C 175 REMARK 465 TYR C 176 REMARK 465 SER C 177 REMARK 465 LEU C 178 REMARK 465 SER C 179 REMARK 465 SER C 180 REMARK 465 VAL C 181 REMARK 465 VAL C 182 REMARK 465 THR C 183 REMARK 465 VAL C 184 REMARK 465 PRO C 185 REMARK 465 SER C 186 REMARK 465 SER C 187 REMARK 465 SER C 188 REMARK 465 LEU C 189 REMARK 465 GLY C 190 REMARK 465 THR C 191 REMARK 465 GLN C 192 REMARK 465 THR C 193 REMARK 465 TYR C 194 REMARK 465 ILE C 195 REMARK 465 CYS C 196 REMARK 465 ASN C 197 REMARK 465 VAL C 198 REMARK 465 ASN C 199 REMARK 465 HIS C 200 REMARK 465 LYS C 201 REMARK 465 PRO C 202 REMARK 465 SER C 203 REMARK 465 ASN C 204 REMARK 465 THR C 205 REMARK 465 LYS C 206 REMARK 465 VAL C 207 REMARK 465 ASP C 208 REMARK 465 LYS C 209 REMARK 465 LYS C 210 REMARK 465 VAL C 211 REMARK 465 GLU C 212 REMARK 465 PRO C 213 REMARK 465 LYS C 214 REMARK 465 SER C 215 REMARK 465 CYS C 216 REMARK 465 ASP C 217 REMARK 465 LYS C 218 REMARK 465 THR C 219 REMARK 465 HIS C 220 REMARK 465 THR C 221 REMARK 465 CYS C 222 REMARK 465 PRO C 223 REMARK 465 PRO C 224 REMARK 465 CYS C 225 REMARK 465 PRO C 226 REMARK 465 ALA C 227 REMARK 465 PRO C 228 REMARK 465 GLU C 229 REMARK 465 LEU C 230 REMARK 465 LEU C 231 REMARK 465 GLY C 232 REMARK 465 GLY C 233 REMARK 465 PRO C 234 REMARK 465 SER C 235 REMARK 465 VAL C 236 REMARK 465 PHE C 237 REMARK 465 LEU C 238 REMARK 465 PHE C 239 REMARK 465 PRO C 240 REMARK 465 PRO C 241 REMARK 465 LYS C 242 REMARK 465 PRO C 243 REMARK 465 LYS C 244 REMARK 465 ASP C 245 REMARK 465 THR C 246 REMARK 465 LEU C 247 REMARK 465 MET C 248 REMARK 465 ILE C 249 REMARK 465 SER C 250 REMARK 465 ARG C 251 REMARK 465 THR C 252 REMARK 465 PRO C 253 REMARK 465 GLU C 254 REMARK 465 VAL C 255 REMARK 465 THR C 256 REMARK 465 CYS C 257 REMARK 465 VAL C 258 REMARK 465 VAL C 259 REMARK 465 VAL C 260 REMARK 465 ASP C 261 REMARK 465 VAL C 262 REMARK 465 SER C 263 REMARK 465 HIS C 264 REMARK 465 GLU C 265 REMARK 465 ASP C 266 REMARK 465 PRO C 267 REMARK 465 GLU C 268 REMARK 465 VAL C 269 REMARK 465 LYS C 270 REMARK 465 PHE C 271 REMARK 465 ASN C 272 REMARK 465 TRP C 273 REMARK 465 TYR C 274 REMARK 465 VAL C 275 REMARK 465 ASP C 276 REMARK 465 GLY C 277 REMARK 465 VAL C 278 REMARK 465 GLU C 279 REMARK 465 VAL C 280 REMARK 465 HIS C 281 REMARK 465 ASN C 282 REMARK 465 ALA C 283 REMARK 465 LYS C 284 REMARK 465 THR C 285 REMARK 465 LYS C 286 REMARK 465 PRO C 287 REMARK 465 ARG C 288 REMARK 465 GLU C 289 REMARK 465 GLU C 290 REMARK 465 GLN C 291 REMARK 465 TYR C 292 REMARK 465 ASN C 293 REMARK 465 SER C 294 REMARK 465 THR C 295 REMARK 465 TYR C 296 REMARK 465 ARG C 297 REMARK 465 VAL C 298 REMARK 465 VAL C 299 REMARK 465 SER C 300 REMARK 465 VAL C 301 REMARK 465 LEU C 302 REMARK 465 THR C 303 REMARK 465 VAL C 304 REMARK 465 LEU C 305 REMARK 465 HIS C 306 REMARK 465 GLN C 307 REMARK 465 ASP C 308 REMARK 465 TRP C 309 REMARK 465 LEU C 310 REMARK 465 ASN C 311 REMARK 465 GLY C 312 REMARK 465 LYS C 313 REMARK 465 GLU C 314 REMARK 465 TYR C 315 REMARK 465 LYS C 316 REMARK 465 CYS C 317 REMARK 465 LYS C 318 REMARK 465 VAL C 319 REMARK 465 SER C 320 REMARK 465 ASN C 321 REMARK 465 LYS C 322 REMARK 465 ALA C 323 REMARK 465 LEU C 324 REMARK 465 PRO C 325 REMARK 465 ALA C 326 REMARK 465 PRO C 327 REMARK 465 ILE C 328 REMARK 465 GLU C 329 REMARK 465 LYS C 330 REMARK 465 THR C 331 REMARK 465 ILE C 332 REMARK 465 SER C 333 REMARK 465 LYS C 334 REMARK 465 ALA C 335 REMARK 465 LYS C 336 REMARK 465 GLY C 337 REMARK 465 GLN C 338 REMARK 465 PRO C 339 REMARK 465 ARG C 340 REMARK 465 GLU C 341 REMARK 465 PRO C 342 REMARK 465 GLN C 343 REMARK 465 VAL C 344 REMARK 465 TYR C 345 REMARK 465 THR C 346 REMARK 465 LEU C 347 REMARK 465 PRO C 348 REMARK 465 PRO C 349 REMARK 465 SER C 350 REMARK 465 ARG C 351 REMARK 465 ASP C 352 REMARK 465 GLU C 353 REMARK 465 LEU C 354 REMARK 465 THR C 355 REMARK 465 LYS C 356 REMARK 465 ASN C 357 REMARK 465 GLN C 358 REMARK 465 VAL C 359 REMARK 465 SER C 360 REMARK 465 LEU C 361 REMARK 465 THR C 362 REMARK 465 CYS C 363 REMARK 465 LEU C 364 REMARK 465 VAL C 365 REMARK 465 LYS C 366 REMARK 465 GLY C 367 REMARK 465 PHE C 368 REMARK 465 TYR C 369 REMARK 465 PRO C 370 REMARK 465 SER C 371 REMARK 465 ASP C 372 REMARK 465 ILE C 373 REMARK 465 ALA C 374 REMARK 465 VAL C 375 REMARK 465 GLU C 376 REMARK 465 TRP C 377 REMARK 465 GLU C 378 REMARK 465 SER C 379 REMARK 465 ASN C 380 REMARK 465 GLY C 381 REMARK 465 GLN C 382 REMARK 465 PRO C 383 REMARK 465 GLU C 384 REMARK 465 ASN C 385 REMARK 465 ASN C 386 REMARK 465 TYR C 387 REMARK 465 LYS C 388 REMARK 465 THR C 389 REMARK 465 THR C 390 REMARK 465 PRO C 391 REMARK 465 PRO C 392 REMARK 465 VAL C 393 REMARK 465 LEU C 394 REMARK 465 ASP C 395 REMARK 465 SER C 396 REMARK 465 ASP C 397 REMARK 465 GLY C 398 REMARK 465 SER C 399 REMARK 465 PHE C 400 REMARK 465 PHE C 401 REMARK 465 LEU C 402 REMARK 465 TYR C 403 REMARK 465 SER C 404 REMARK 465 LYS C 405 REMARK 465 LEU C 406 REMARK 465 THR C 407 REMARK 465 VAL C 408 REMARK 465 ASP C 409 REMARK 465 LYS C 410 REMARK 465 SER C 411 REMARK 465 ARG C 412 REMARK 465 TRP C 413 REMARK 465 GLN C 414 REMARK 465 GLN C 415 REMARK 465 GLY C 416 REMARK 465 ASN C 417 REMARK 465 VAL C 418 REMARK 465 PHE C 419 REMARK 465 SER C 420 REMARK 465 CYS C 421 REMARK 465 SER C 422 REMARK 465 VAL C 423 REMARK 465 MET C 424 REMARK 465 HIS C 425 REMARK 465 GLU C 426 REMARK 465 ALA C 427 REMARK 465 LEU C 428 REMARK 465 HIS C 429 REMARK 465 ASN C 430 REMARK 465 HIS C 431 REMARK 465 TYR C 432 REMARK 465 THR C 433 REMARK 465 GLN C 434 REMARK 465 LYS C 435 REMARK 465 SER C 436 REMARK 465 LEU C 437 REMARK 465 SER C 438 REMARK 465 LEU C 439 REMARK 465 SER C 440 REMARK 465 PRO C 441 REMARK 465 GLY C 442 REMARK 465 GLN F 1 REMARK 465 SER F 2 REMARK 465 LEU F 107 REMARK 465 GLY F 108 REMARK 465 GLN F 109 REMARK 465 PRO F 110 REMARK 465 LYS F 111 REMARK 465 ALA F 112 REMARK 465 ASN F 113 REMARK 465 PRO F 114 REMARK 465 THR F 115 REMARK 465 VAL F 116 REMARK 465 THR F 117 REMARK 465 LEU F 118 REMARK 465 PHE F 119 REMARK 465 PRO F 120 REMARK 465 PRO F 121 REMARK 465 SER F 122 REMARK 465 SER F 123 REMARK 465 GLU F 124 REMARK 465 GLU F 125 REMARK 465 LEU F 126 REMARK 465 GLN F 127 REMARK 465 ALA F 128 REMARK 465 ASN F 129 REMARK 465 LYS F 130 REMARK 465 ALA F 131 REMARK 465 THR F 132 REMARK 465 LEU F 133 REMARK 465 VAL F 134 REMARK 465 CYS F 135 REMARK 465 LEU F 136 REMARK 465 ILE F 137 REMARK 465 SER F 138 REMARK 465 ASP F 139 REMARK 465 PHE F 140 REMARK 465 TYR F 141 REMARK 465 PRO F 142 REMARK 465 GLY F 143 REMARK 465 ALA F 144 REMARK 465 VAL F 145 REMARK 465 THR F 146 REMARK 465 VAL F 147 REMARK 465 ALA F 148 REMARK 465 TRP F 149 REMARK 465 LYS F 150 REMARK 465 ALA F 151 REMARK 465 ASP F 152 REMARK 465 GLY F 153 REMARK 465 SER F 154 REMARK 465 PRO F 155 REMARK 465 VAL F 156 REMARK 465 LYS F 157 REMARK 465 ALA F 158 REMARK 465 GLY F 159 REMARK 465 VAL F 160 REMARK 465 GLU F 161 REMARK 465 THR F 162 REMARK 465 THR F 163 REMARK 465 LYS F 164 REMARK 465 PRO F 165 REMARK 465 SER F 166 REMARK 465 LYS F 167 REMARK 465 GLN F 168 REMARK 465 SER F 169 REMARK 465 ASN F 170 REMARK 465 ASN F 171 REMARK 465 LYS F 172 REMARK 465 TYR F 173 REMARK 465 ALA F 174 REMARK 465 ALA F 175 REMARK 465 SER F 176 REMARK 465 SER F 177 REMARK 465 TYR F 178 REMARK 465 LEU F 179 REMARK 465 SER F 180 REMARK 465 LEU F 181 REMARK 465 THR F 182 REMARK 465 PRO F 183 REMARK 465 GLU F 184 REMARK 465 GLN F 185 REMARK 465 TRP F 186 REMARK 465 LYS F 187 REMARK 465 SER F 188 REMARK 465 HIS F 189 REMARK 465 ARG F 190 REMARK 465 SER F 191 REMARK 465 TYR F 192 REMARK 465 SER F 193 REMARK 465 CYS F 194 REMARK 465 GLN F 195 REMARK 465 VAL F 196 REMARK 465 THR F 197 REMARK 465 HIS F 198 REMARK 465 GLU F 199 REMARK 465 GLY F 200 REMARK 465 SER F 201 REMARK 465 THR F 202 REMARK 465 VAL F 203 REMARK 465 GLU F 204 REMARK 465 LYS F 205 REMARK 465 THR F 206 REMARK 465 VAL F 207 REMARK 465 ALA F 208 REMARK 465 PRO F 209 REMARK 465 THR F 210 REMARK 465 GLU F 211 REMARK 465 CYS F 212 REMARK 465 SER F 213 REMARK 465 ALA E 114 REMARK 465 SER E 115 REMARK 465 THR E 116 REMARK 465 LYS E 117 REMARK 465 GLY E 118 REMARK 465 PRO E 119 REMARK 465 SER E 120 REMARK 465 VAL E 121 REMARK 465 PHE E 122 REMARK 465 PRO E 123 REMARK 465 LEU E 124 REMARK 465 ALA E 125 REMARK 465 PRO E 126 REMARK 465 SER E 127 REMARK 465 SER E 128 REMARK 465 LYS E 129 REMARK 465 SER E 130 REMARK 465 THR E 131 REMARK 465 SER E 132 REMARK 465 GLY E 133 REMARK 465 GLY E 134 REMARK 465 THR E 135 REMARK 465 ALA E 136 REMARK 465 ALA E 137 REMARK 465 LEU E 138 REMARK 465 GLY E 139 REMARK 465 CYS E 140 REMARK 465 LEU E 141 REMARK 465 VAL E 142 REMARK 465 LYS E 143 REMARK 465 ASP E 144 REMARK 465 TYR E 145 REMARK 465 PHE E 146 REMARK 465 PRO E 147 REMARK 465 GLU E 148 REMARK 465 PRO E 149 REMARK 465 VAL E 150 REMARK 465 THR E 151 REMARK 465 VAL E 152 REMARK 465 SER E 153 REMARK 465 TRP E 154 REMARK 465 ASN E 155 REMARK 465 SER E 156 REMARK 465 GLY E 157 REMARK 465 ALA E 158 REMARK 465 LEU E 159 REMARK 465 THR E 160 REMARK 465 SER E 161 REMARK 465 GLY E 162 REMARK 465 VAL E 163 REMARK 465 HIS E 164 REMARK 465 THR E 165 REMARK 465 PHE E 166 REMARK 465 PRO E 167 REMARK 465 ALA E 168 REMARK 465 VAL E 169 REMARK 465 LEU E 170 REMARK 465 GLN E 171 REMARK 465 SER E 172 REMARK 465 SER E 173 REMARK 465 GLY E 174 REMARK 465 LEU E 175 REMARK 465 TYR E 176 REMARK 465 SER E 177 REMARK 465 LEU E 178 REMARK 465 SER E 179 REMARK 465 SER E 180 REMARK 465 VAL E 181 REMARK 465 VAL E 182 REMARK 465 THR E 183 REMARK 465 VAL E 184 REMARK 465 PRO E 185 REMARK 465 SER E 186 REMARK 465 SER E 187 REMARK 465 SER E 188 REMARK 465 LEU E 189 REMARK 465 GLY E 190 REMARK 465 THR E 191 REMARK 465 GLN E 192 REMARK 465 THR E 193 REMARK 465 TYR E 194 REMARK 465 ILE E 195 REMARK 465 CYS E 196 REMARK 465 ASN E 197 REMARK 465 VAL E 198 REMARK 465 ASN E 199 REMARK 465 HIS E 200 REMARK 465 LYS E 201 REMARK 465 PRO E 202 REMARK 465 SER E 203 REMARK 465 ASN E 204 REMARK 465 THR E 205 REMARK 465 LYS E 206 REMARK 465 VAL E 207 REMARK 465 ASP E 208 REMARK 465 LYS E 209 REMARK 465 LYS E 210 REMARK 465 VAL E 211 REMARK 465 GLU E 212 REMARK 465 PRO E 213 REMARK 465 LYS E 214 REMARK 465 SER E 215 REMARK 465 CYS E 216 REMARK 465 ASP E 217 REMARK 465 LYS E 218 REMARK 465 THR E 219 REMARK 465 HIS E 220 REMARK 465 THR E 221 REMARK 465 CYS E 222 REMARK 465 PRO E 223 REMARK 465 PRO E 224 REMARK 465 CYS E 225 REMARK 465 PRO E 226 REMARK 465 ALA E 227 REMARK 465 PRO E 228 REMARK 465 GLU E 229 REMARK 465 LEU E 230 REMARK 465 LEU E 231 REMARK 465 GLY E 232 REMARK 465 GLY E 233 REMARK 465 PRO E 234 REMARK 465 SER E 235 REMARK 465 VAL E 236 REMARK 465 PHE E 237 REMARK 465 LEU E 238 REMARK 465 PHE E 239 REMARK 465 PRO E 240 REMARK 465 PRO E 241 REMARK 465 LYS E 242 REMARK 465 PRO E 243 REMARK 465 LYS E 244 REMARK 465 ASP E 245 REMARK 465 THR E 246 REMARK 465 LEU E 247 REMARK 465 MET E 248 REMARK 465 ILE E 249 REMARK 465 SER E 250 REMARK 465 ARG E 251 REMARK 465 THR E 252 REMARK 465 PRO E 253 REMARK 465 GLU E 254 REMARK 465 VAL E 255 REMARK 465 THR E 256 REMARK 465 CYS E 257 REMARK 465 VAL E 258 REMARK 465 VAL E 259 REMARK 465 VAL E 260 REMARK 465 ASP E 261 REMARK 465 VAL E 262 REMARK 465 SER E 263 REMARK 465 HIS E 264 REMARK 465 GLU E 265 REMARK 465 ASP E 266 REMARK 465 PRO E 267 REMARK 465 GLU E 268 REMARK 465 VAL E 269 REMARK 465 LYS E 270 REMARK 465 PHE E 271 REMARK 465 ASN E 272 REMARK 465 TRP E 273 REMARK 465 TYR E 274 REMARK 465 VAL E 275 REMARK 465 ASP E 276 REMARK 465 GLY E 277 REMARK 465 VAL E 278 REMARK 465 GLU E 279 REMARK 465 VAL E 280 REMARK 465 HIS E 281 REMARK 465 ASN E 282 REMARK 465 ALA E 283 REMARK 465 LYS E 284 REMARK 465 THR E 285 REMARK 465 LYS E 286 REMARK 465 PRO E 287 REMARK 465 ARG E 288 REMARK 465 GLU E 289 REMARK 465 GLU E 290 REMARK 465 GLN E 291 REMARK 465 TYR E 292 REMARK 465 ASN E 293 REMARK 465 SER E 294 REMARK 465 THR E 295 REMARK 465 TYR E 296 REMARK 465 ARG E 297 REMARK 465 VAL E 298 REMARK 465 VAL E 299 REMARK 465 SER E 300 REMARK 465 VAL E 301 REMARK 465 LEU E 302 REMARK 465 THR E 303 REMARK 465 VAL E 304 REMARK 465 LEU E 305 REMARK 465 HIS E 306 REMARK 465 GLN E 307 REMARK 465 ASP E 308 REMARK 465 TRP E 309 REMARK 465 LEU E 310 REMARK 465 ASN E 311 REMARK 465 GLY E 312 REMARK 465 LYS E 313 REMARK 465 GLU E 314 REMARK 465 TYR E 315 REMARK 465 LYS E 316 REMARK 465 CYS E 317 REMARK 465 LYS E 318 REMARK 465 VAL E 319 REMARK 465 SER E 320 REMARK 465 ASN E 321 REMARK 465 LYS E 322 REMARK 465 ALA E 323 REMARK 465 LEU E 324 REMARK 465 PRO E 325 REMARK 465 ALA E 326 REMARK 465 PRO E 327 REMARK 465 ILE E 328 REMARK 465 GLU E 329 REMARK 465 LYS E 330 REMARK 465 THR E 331 REMARK 465 ILE E 332 REMARK 465 SER E 333 REMARK 465 LYS E 334 REMARK 465 ALA E 335 REMARK 465 LYS E 336 REMARK 465 GLY E 337 REMARK 465 GLN E 338 REMARK 465 PRO E 339 REMARK 465 ARG E 340 REMARK 465 GLU E 341 REMARK 465 PRO E 342 REMARK 465 GLN E 343 REMARK 465 VAL E 344 REMARK 465 TYR E 345 REMARK 465 THR E 346 REMARK 465 LEU E 347 REMARK 465 PRO E 348 REMARK 465 PRO E 349 REMARK 465 SER E 350 REMARK 465 ARG E 351 REMARK 465 ASP E 352 REMARK 465 GLU E 353 REMARK 465 LEU E 354 REMARK 465 THR E 355 REMARK 465 LYS E 356 REMARK 465 ASN E 357 REMARK 465 GLN E 358 REMARK 465 VAL E 359 REMARK 465 SER E 360 REMARK 465 LEU E 361 REMARK 465 THR E 362 REMARK 465 CYS E 363 REMARK 465 LEU E 364 REMARK 465 VAL E 365 REMARK 465 LYS E 366 REMARK 465 GLY E 367 REMARK 465 PHE E 368 REMARK 465 TYR E 369 REMARK 465 PRO E 370 REMARK 465 SER E 371 REMARK 465 ASP E 372 REMARK 465 ILE E 373 REMARK 465 ALA E 374 REMARK 465 VAL E 375 REMARK 465 GLU E 376 REMARK 465 TRP E 377 REMARK 465 GLU E 378 REMARK 465 SER E 379 REMARK 465 ASN E 380 REMARK 465 GLY E 381 REMARK 465 GLN E 382 REMARK 465 PRO E 383 REMARK 465 GLU E 384 REMARK 465 ASN E 385 REMARK 465 ASN E 386 REMARK 465 TYR E 387 REMARK 465 LYS E 388 REMARK 465 THR E 389 REMARK 465 THR E 390 REMARK 465 PRO E 391 REMARK 465 PRO E 392 REMARK 465 VAL E 393 REMARK 465 LEU E 394 REMARK 465 ASP E 395 REMARK 465 SER E 396 REMARK 465 ASP E 397 REMARK 465 GLY E 398 REMARK 465 SER E 399 REMARK 465 PHE E 400 REMARK 465 PHE E 401 REMARK 465 LEU E 402 REMARK 465 TYR E 403 REMARK 465 SER E 404 REMARK 465 LYS E 405 REMARK 465 LEU E 406 REMARK 465 THR E 407 REMARK 465 VAL E 408 REMARK 465 ASP E 409 REMARK 465 LYS E 410 REMARK 465 SER E 411 REMARK 465 ARG E 412 REMARK 465 TRP E 413 REMARK 465 GLN E 414 REMARK 465 GLN E 415 REMARK 465 GLY E 416 REMARK 465 ASN E 417 REMARK 465 VAL E 418 REMARK 465 PHE E 419 REMARK 465 SER E 420 REMARK 465 CYS E 421 REMARK 465 SER E 422 REMARK 465 VAL E 423 REMARK 465 MET E 424 REMARK 465 HIS E 425 REMARK 465 GLU E 426 REMARK 465 ALA E 427 REMARK 465 LEU E 428 REMARK 465 HIS E 429 REMARK 465 ASN E 430 REMARK 465 HIS E 431 REMARK 465 TYR E 432 REMARK 465 THR E 433 REMARK 465 GLN E 434 REMARK 465 LYS E 435 REMARK 465 SER E 436 REMARK 465 LEU E 437 REMARK 465 SER E 438 REMARK 465 LEU E 439 REMARK 465 SER E 440 REMARK 465 PRO E 441 REMARK 465 GLY E 442 REMARK 465 GLN N 1 REMARK 465 SER N 2 REMARK 465 LEU N 107 REMARK 465 GLY N 108 REMARK 465 GLN N 109 REMARK 465 PRO N 110 REMARK 465 LYS N 111 REMARK 465 ALA N 112 REMARK 465 ASN N 113 REMARK 465 PRO N 114 REMARK 465 THR N 115 REMARK 465 VAL N 116 REMARK 465 THR N 117 REMARK 465 LEU N 118 REMARK 465 PHE N 119 REMARK 465 PRO N 120 REMARK 465 PRO N 121 REMARK 465 SER N 122 REMARK 465 SER N 123 REMARK 465 GLU N 124 REMARK 465 GLU N 125 REMARK 465 LEU N 126 REMARK 465 GLN N 127 REMARK 465 ALA N 128 REMARK 465 ASN N 129 REMARK 465 LYS N 130 REMARK 465 ALA N 131 REMARK 465 THR N 132 REMARK 465 LEU N 133 REMARK 465 VAL N 134 REMARK 465 CYS N 135 REMARK 465 LEU N 136 REMARK 465 ILE N 137 REMARK 465 SER N 138 REMARK 465 ASP N 139 REMARK 465 PHE N 140 REMARK 465 TYR N 141 REMARK 465 PRO N 142 REMARK 465 GLY N 143 REMARK 465 ALA N 144 REMARK 465 VAL N 145 REMARK 465 THR N 146 REMARK 465 VAL N 147 REMARK 465 ALA N 148 REMARK 465 TRP N 149 REMARK 465 LYS N 150 REMARK 465 ALA N 151 REMARK 465 ASP N 152 REMARK 465 GLY N 153 REMARK 465 SER N 154 REMARK 465 PRO N 155 REMARK 465 VAL N 156 REMARK 465 LYS N 157 REMARK 465 ALA N 158 REMARK 465 GLY N 159 REMARK 465 VAL N 160 REMARK 465 GLU N 161 REMARK 465 THR N 162 REMARK 465 THR N 163 REMARK 465 LYS N 164 REMARK 465 PRO N 165 REMARK 465 SER N 166 REMARK 465 LYS N 167 REMARK 465 GLN N 168 REMARK 465 SER N 169 REMARK 465 ASN N 170 REMARK 465 ASN N 171 REMARK 465 LYS N 172 REMARK 465 TYR N 173 REMARK 465 ALA N 174 REMARK 465 ALA N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 TYR N 178 REMARK 465 LEU N 179 REMARK 465 SER N 180 REMARK 465 LEU N 181 REMARK 465 THR N 182 REMARK 465 PRO N 183 REMARK 465 GLU N 184 REMARK 465 GLN N 185 REMARK 465 TRP N 186 REMARK 465 LYS N 187 REMARK 465 SER N 188 REMARK 465 HIS N 189 REMARK 465 ARG N 190 REMARK 465 SER N 191 REMARK 465 TYR N 192 REMARK 465 SER N 193 REMARK 465 CYS N 194 REMARK 465 GLN N 195 REMARK 465 VAL N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 GLU N 199 REMARK 465 GLY N 200 REMARK 465 SER N 201 REMARK 465 THR N 202 REMARK 465 VAL N 203 REMARK 465 GLU N 204 REMARK 465 LYS N 205 REMARK 465 THR N 206 REMARK 465 VAL N 207 REMARK 465 ALA N 208 REMARK 465 PRO N 209 REMARK 465 THR N 210 REMARK 465 GLU N 211 REMARK 465 CYS N 212 REMARK 465 SER N 213 REMARK 465 ALA M 114 REMARK 465 SER M 115 REMARK 465 THR M 116 REMARK 465 LYS M 117 REMARK 465 GLY M 118 REMARK 465 PRO M 119 REMARK 465 SER M 120 REMARK 465 VAL M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 LEU M 124 REMARK 465 ALA M 125 REMARK 465 PRO M 126 REMARK 465 SER M 127 REMARK 465 SER M 128 REMARK 465 LYS M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 SER M 132 REMARK 465 GLY M 133 REMARK 465 GLY M 134 REMARK 465 THR M 135 REMARK 465 ALA M 136 REMARK 465 ALA M 137 REMARK 465 LEU M 138 REMARK 465 GLY M 139 REMARK 465 CYS M 140 REMARK 465 LEU M 141 REMARK 465 VAL M 142 REMARK 465 LYS M 143 REMARK 465 ASP M 144 REMARK 465 TYR M 145 REMARK 465 PHE M 146 REMARK 465 PRO M 147 REMARK 465 GLU M 148 REMARK 465 PRO M 149 REMARK 465 VAL M 150 REMARK 465 THR M 151 REMARK 465 VAL M 152 REMARK 465 SER M 153 REMARK 465 TRP M 154 REMARK 465 ASN M 155 REMARK 465 SER M 156 REMARK 465 GLY M 157 REMARK 465 ALA M 158 REMARK 465 LEU M 159 REMARK 465 THR M 160 REMARK 465 SER M 161 REMARK 465 GLY M 162 REMARK 465 VAL M 163 REMARK 465 HIS M 164 REMARK 465 THR M 165 REMARK 465 PHE M 166 REMARK 465 PRO M 167 REMARK 465 ALA M 168 REMARK 465 VAL M 169 REMARK 465 LEU M 170 REMARK 465 GLN M 171 REMARK 465 SER M 172 REMARK 465 SER M 173 REMARK 465 GLY M 174 REMARK 465 LEU M 175 REMARK 465 TYR M 176 REMARK 465 SER M 177 REMARK 465 LEU M 178 REMARK 465 SER M 179 REMARK 465 SER M 180 REMARK 465 VAL M 181 REMARK 465 VAL M 182 REMARK 465 THR M 183 REMARK 465 VAL M 184 REMARK 465 PRO M 185 REMARK 465 SER M 186 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 LEU M 189 REMARK 465 GLY M 190 REMARK 465 THR M 191 REMARK 465 GLN M 192 REMARK 465 THR M 193 REMARK 465 TYR M 194 REMARK 465 ILE M 195 REMARK 465 CYS M 196 REMARK 465 ASN M 197 REMARK 465 VAL M 198 REMARK 465 ASN M 199 REMARK 465 HIS M 200 REMARK 465 LYS M 201 REMARK 465 PRO M 202 REMARK 465 SER M 203 REMARK 465 ASN M 204 REMARK 465 THR M 205 REMARK 465 LYS M 206 REMARK 465 VAL M 207 REMARK 465 ASP M 208 REMARK 465 LYS M 209 REMARK 465 LYS M 210 REMARK 465 VAL M 211 REMARK 465 GLU M 212 REMARK 465 PRO M 213 REMARK 465 LYS M 214 REMARK 465 SER M 215 REMARK 465 CYS M 216 REMARK 465 ASP M 217 REMARK 465 LYS M 218 REMARK 465 THR M 219 REMARK 465 HIS M 220 REMARK 465 THR M 221 REMARK 465 CYS M 222 REMARK 465 PRO M 223 REMARK 465 PRO M 224 REMARK 465 CYS M 225 REMARK 465 PRO M 226 REMARK 465 ALA M 227 REMARK 465 PRO M 228 REMARK 465 GLU M 229 REMARK 465 LEU M 230 REMARK 465 LEU M 231 REMARK 465 GLY M 232 REMARK 465 GLY M 233 REMARK 465 PRO M 234 REMARK 465 SER M 235 REMARK 465 VAL M 236 REMARK 465 PHE M 237 REMARK 465 LEU M 238 REMARK 465 PHE M 239 REMARK 465 PRO M 240 REMARK 465 PRO M 241 REMARK 465 LYS M 242 REMARK 465 PRO M 243 REMARK 465 LYS M 244 REMARK 465 ASP M 245 REMARK 465 THR M 246 REMARK 465 LEU M 247 REMARK 465 MET M 248 REMARK 465 ILE M 249 REMARK 465 SER M 250 REMARK 465 ARG M 251 REMARK 465 THR M 252 REMARK 465 PRO M 253 REMARK 465 GLU M 254 REMARK 465 VAL M 255 REMARK 465 THR M 256 REMARK 465 CYS M 257 REMARK 465 VAL M 258 REMARK 465 VAL M 259 REMARK 465 VAL M 260 REMARK 465 ASP M 261 REMARK 465 VAL M 262 REMARK 465 SER M 263 REMARK 465 HIS M 264 REMARK 465 GLU M 265 REMARK 465 ASP M 266 REMARK 465 PRO M 267 REMARK 465 GLU M 268 REMARK 465 VAL M 269 REMARK 465 LYS M 270 REMARK 465 PHE M 271 REMARK 465 ASN M 272 REMARK 465 TRP M 273 REMARK 465 TYR M 274 REMARK 465 VAL M 275 REMARK 465 ASP M 276 REMARK 465 GLY M 277 REMARK 465 VAL M 278 REMARK 465 GLU M 279 REMARK 465 VAL M 280 REMARK 465 HIS M 281 REMARK 465 ASN M 282 REMARK 465 ALA M 283 REMARK 465 LYS M 284 REMARK 465 THR M 285 REMARK 465 LYS M 286 REMARK 465 PRO M 287 REMARK 465 ARG M 288 REMARK 465 GLU M 289 REMARK 465 GLU M 290 REMARK 465 GLN M 291 REMARK 465 TYR M 292 REMARK 465 ASN M 293 REMARK 465 SER M 294 REMARK 465 THR M 295 REMARK 465 TYR M 296 REMARK 465 ARG M 297 REMARK 465 VAL M 298 REMARK 465 VAL M 299 REMARK 465 SER M 300 REMARK 465 VAL M 301 REMARK 465 LEU M 302 REMARK 465 THR M 303 REMARK 465 VAL M 304 REMARK 465 LEU M 305 REMARK 465 HIS M 306 REMARK 465 GLN M 307 REMARK 465 ASP M 308 REMARK 465 TRP M 309 REMARK 465 LEU M 310 REMARK 465 ASN M 311 REMARK 465 GLY M 312 REMARK 465 LYS M 313 REMARK 465 GLU M 314 REMARK 465 TYR M 315 REMARK 465 LYS M 316 REMARK 465 CYS M 317 REMARK 465 LYS M 318 REMARK 465 VAL M 319 REMARK 465 SER M 320 REMARK 465 ASN M 321 REMARK 465 LYS M 322 REMARK 465 ALA M 323 REMARK 465 LEU M 324 REMARK 465 PRO M 325 REMARK 465 ALA M 326 REMARK 465 PRO M 327 REMARK 465 ILE M 328 REMARK 465 GLU M 329 REMARK 465 LYS M 330 REMARK 465 THR M 331 REMARK 465 ILE M 332 REMARK 465 SER M 333 REMARK 465 LYS M 334 REMARK 465 ALA M 335 REMARK 465 LYS M 336 REMARK 465 GLY M 337 REMARK 465 GLN M 338 REMARK 465 PRO M 339 REMARK 465 ARG M 340 REMARK 465 GLU M 341 REMARK 465 PRO M 342 REMARK 465 GLN M 343 REMARK 465 VAL M 344 REMARK 465 TYR M 345 REMARK 465 THR M 346 REMARK 465 LEU M 347 REMARK 465 PRO M 348 REMARK 465 PRO M 349 REMARK 465 SER M 350 REMARK 465 ARG M 351 REMARK 465 ASP M 352 REMARK 465 GLU M 353 REMARK 465 LEU M 354 REMARK 465 THR M 355 REMARK 465 LYS M 356 REMARK 465 ASN M 357 REMARK 465 GLN M 358 REMARK 465 VAL M 359 REMARK 465 SER M 360 REMARK 465 LEU M 361 REMARK 465 THR M 362 REMARK 465 CYS M 363 REMARK 465 LEU M 364 REMARK 465 VAL M 365 REMARK 465 LYS M 366 REMARK 465 GLY M 367 REMARK 465 PHE M 368 REMARK 465 TYR M 369 REMARK 465 PRO M 370 REMARK 465 SER M 371 REMARK 465 ASP M 372 REMARK 465 ILE M 373 REMARK 465 ALA M 374 REMARK 465 VAL M 375 REMARK 465 GLU M 376 REMARK 465 TRP M 377 REMARK 465 GLU M 378 REMARK 465 SER M 379 REMARK 465 ASN M 380 REMARK 465 GLY M 381 REMARK 465 GLN M 382 REMARK 465 PRO M 383 REMARK 465 GLU M 384 REMARK 465 ASN M 385 REMARK 465 ASN M 386 REMARK 465 TYR M 387 REMARK 465 LYS M 388 REMARK 465 THR M 389 REMARK 465 THR M 390 REMARK 465 PRO M 391 REMARK 465 PRO M 392 REMARK 465 VAL M 393 REMARK 465 LEU M 394 REMARK 465 ASP M 395 REMARK 465 SER M 396 REMARK 465 ASP M 397 REMARK 465 GLY M 398 REMARK 465 SER M 399 REMARK 465 PHE M 400 REMARK 465 PHE M 401 REMARK 465 LEU M 402 REMARK 465 TYR M 403 REMARK 465 SER M 404 REMARK 465 LYS M 405 REMARK 465 LEU M 406 REMARK 465 THR M 407 REMARK 465 VAL M 408 REMARK 465 ASP M 409 REMARK 465 LYS M 410 REMARK 465 SER M 411 REMARK 465 ARG M 412 REMARK 465 TRP M 413 REMARK 465 GLN M 414 REMARK 465 GLN M 415 REMARK 465 GLY M 416 REMARK 465 ASN M 417 REMARK 465 VAL M 418 REMARK 465 PHE M 419 REMARK 465 SER M 420 REMARK 465 CYS M 421 REMARK 465 SER M 422 REMARK 465 VAL M 423 REMARK 465 MET M 424 REMARK 465 HIS M 425 REMARK 465 GLU M 426 REMARK 465 ALA M 427 REMARK 465 LEU M 428 REMARK 465 HIS M 429 REMARK 465 ASN M 430 REMARK 465 HIS M 431 REMARK 465 TYR M 432 REMARK 465 THR M 433 REMARK 465 GLN M 434 REMARK 465 LYS M 435 REMARK 465 SER M 436 REMARK 465 LEU M 437 REMARK 465 SER M 438 REMARK 465 LEU M 439 REMARK 465 SER M 440 REMARK 465 PRO M 441 REMARK 465 GLY M 442 REMARK 465 GLN P 1 REMARK 465 SER P 2 REMARK 465 LEU P 107 REMARK 465 GLY P 108 REMARK 465 GLN P 109 REMARK 465 PRO P 110 REMARK 465 LYS P 111 REMARK 465 ALA P 112 REMARK 465 ASN P 113 REMARK 465 PRO P 114 REMARK 465 THR P 115 REMARK 465 VAL P 116 REMARK 465 THR P 117 REMARK 465 LEU P 118 REMARK 465 PHE P 119 REMARK 465 PRO P 120 REMARK 465 PRO P 121 REMARK 465 SER P 122 REMARK 465 SER P 123 REMARK 465 GLU P 124 REMARK 465 GLU P 125 REMARK 465 LEU P 126 REMARK 465 GLN P 127 REMARK 465 ALA P 128 REMARK 465 ASN P 129 REMARK 465 LYS P 130 REMARK 465 ALA P 131 REMARK 465 THR P 132 REMARK 465 LEU P 133 REMARK 465 VAL P 134 REMARK 465 CYS P 135 REMARK 465 LEU P 136 REMARK 465 ILE P 137 REMARK 465 SER P 138 REMARK 465 ASP P 139 REMARK 465 PHE P 140 REMARK 465 TYR P 141 REMARK 465 PRO P 142 REMARK 465 GLY P 143 REMARK 465 ALA P 144 REMARK 465 VAL P 145 REMARK 465 THR P 146 REMARK 465 VAL P 147 REMARK 465 ALA P 148 REMARK 465 TRP P 149 REMARK 465 LYS P 150 REMARK 465 ALA P 151 REMARK 465 ASP P 152 REMARK 465 GLY P 153 REMARK 465 SER P 154 REMARK 465 PRO P 155 REMARK 465 VAL P 156 REMARK 465 LYS P 157 REMARK 465 ALA P 158 REMARK 465 GLY P 159 REMARK 465 VAL P 160 REMARK 465 GLU P 161 REMARK 465 THR P 162 REMARK 465 THR P 163 REMARK 465 LYS P 164 REMARK 465 PRO P 165 REMARK 465 SER P 166 REMARK 465 LYS P 167 REMARK 465 GLN P 168 REMARK 465 SER P 169 REMARK 465 ASN P 170 REMARK 465 ASN P 171 REMARK 465 LYS P 172 REMARK 465 TYR P 173 REMARK 465 ALA P 174 REMARK 465 ALA P 175 REMARK 465 SER P 176 REMARK 465 SER P 177 REMARK 465 TYR P 178 REMARK 465 LEU P 179 REMARK 465 SER P 180 REMARK 465 LEU P 181 REMARK 465 THR P 182 REMARK 465 PRO P 183 REMARK 465 GLU P 184 REMARK 465 GLN P 185 REMARK 465 TRP P 186 REMARK 465 LYS P 187 REMARK 465 SER P 188 REMARK 465 HIS P 189 REMARK 465 ARG P 190 REMARK 465 SER P 191 REMARK 465 TYR P 192 REMARK 465 SER P 193 REMARK 465 CYS P 194 REMARK 465 GLN P 195 REMARK 465 VAL P 196 REMARK 465 THR P 197 REMARK 465 HIS P 198 REMARK 465 GLU P 199 REMARK 465 GLY P 200 REMARK 465 SER P 201 REMARK 465 THR P 202 REMARK 465 VAL P 203 REMARK 465 GLU P 204 REMARK 465 LYS P 205 REMARK 465 THR P 206 REMARK 465 VAL P 207 REMARK 465 ALA P 208 REMARK 465 PRO P 209 REMARK 465 THR P 210 REMARK 465 GLU P 211 REMARK 465 CYS P 212 REMARK 465 SER P 213 REMARK 465 ALA O 114 REMARK 465 SER O 115 REMARK 465 THR O 116 REMARK 465 LYS O 117 REMARK 465 GLY O 118 REMARK 465 PRO O 119 REMARK 465 SER O 120 REMARK 465 VAL O 121 REMARK 465 PHE O 122 REMARK 465 PRO O 123 REMARK 465 LEU O 124 REMARK 465 ALA O 125 REMARK 465 PRO O 126 REMARK 465 SER O 127 REMARK 465 SER O 128 REMARK 465 LYS O 129 REMARK 465 SER O 130 REMARK 465 THR O 131 REMARK 465 SER O 132 REMARK 465 GLY O 133 REMARK 465 GLY O 134 REMARK 465 THR O 135 REMARK 465 ALA O 136 REMARK 465 ALA O 137 REMARK 465 LEU O 138 REMARK 465 GLY O 139 REMARK 465 CYS O 140 REMARK 465 LEU O 141 REMARK 465 VAL O 142 REMARK 465 LYS O 143 REMARK 465 ASP O 144 REMARK 465 TYR O 145 REMARK 465 PHE O 146 REMARK 465 PRO O 147 REMARK 465 GLU O 148 REMARK 465 PRO O 149 REMARK 465 VAL O 150 REMARK 465 THR O 151 REMARK 465 VAL O 152 REMARK 465 SER O 153 REMARK 465 TRP O 154 REMARK 465 ASN O 155 REMARK 465 SER O 156 REMARK 465 GLY O 157 REMARK 465 ALA O 158 REMARK 465 LEU O 159 REMARK 465 THR O 160 REMARK 465 SER O 161 REMARK 465 GLY O 162 REMARK 465 VAL O 163 REMARK 465 HIS O 164 REMARK 465 THR O 165 REMARK 465 PHE O 166 REMARK 465 PRO O 167 REMARK 465 ALA O 168 REMARK 465 VAL O 169 REMARK 465 LEU O 170 REMARK 465 GLN O 171 REMARK 465 SER O 172 REMARK 465 SER O 173 REMARK 465 GLY O 174 REMARK 465 LEU O 175 REMARK 465 TYR O 176 REMARK 465 SER O 177 REMARK 465 LEU O 178 REMARK 465 SER O 179 REMARK 465 SER O 180 REMARK 465 VAL O 181 REMARK 465 VAL O 182 REMARK 465 THR O 183 REMARK 465 VAL O 184 REMARK 465 PRO O 185 REMARK 465 SER O 186 REMARK 465 SER O 187 REMARK 465 SER O 188 REMARK 465 LEU O 189 REMARK 465 GLY O 190 REMARK 465 THR O 191 REMARK 465 GLN O 192 REMARK 465 THR O 193 REMARK 465 TYR O 194 REMARK 465 ILE O 195 REMARK 465 CYS O 196 REMARK 465 ASN O 197 REMARK 465 VAL O 198 REMARK 465 ASN O 199 REMARK 465 HIS O 200 REMARK 465 LYS O 201 REMARK 465 PRO O 202 REMARK 465 SER O 203 REMARK 465 ASN O 204 REMARK 465 THR O 205 REMARK 465 LYS O 206 REMARK 465 VAL O 207 REMARK 465 ASP O 208 REMARK 465 LYS O 209 REMARK 465 LYS O 210 REMARK 465 VAL O 211 REMARK 465 GLU O 212 REMARK 465 PRO O 213 REMARK 465 LYS O 214 REMARK 465 SER O 215 REMARK 465 CYS O 216 REMARK 465 ASP O 217 REMARK 465 LYS O 218 REMARK 465 THR O 219 REMARK 465 HIS O 220 REMARK 465 THR O 221 REMARK 465 CYS O 222 REMARK 465 PRO O 223 REMARK 465 PRO O 224 REMARK 465 CYS O 225 REMARK 465 PRO O 226 REMARK 465 ALA O 227 REMARK 465 PRO O 228 REMARK 465 GLU O 229 REMARK 465 LEU O 230 REMARK 465 LEU O 231 REMARK 465 GLY O 232 REMARK 465 GLY O 233 REMARK 465 PRO O 234 REMARK 465 SER O 235 REMARK 465 VAL O 236 REMARK 465 PHE O 237 REMARK 465 LEU O 238 REMARK 465 PHE O 239 REMARK 465 PRO O 240 REMARK 465 PRO O 241 REMARK 465 LYS O 242 REMARK 465 PRO O 243 REMARK 465 LYS O 244 REMARK 465 ASP O 245 REMARK 465 THR O 246 REMARK 465 LEU O 247 REMARK 465 MET O 248 REMARK 465 ILE O 249 REMARK 465 SER O 250 REMARK 465 ARG O 251 REMARK 465 THR O 252 REMARK 465 PRO O 253 REMARK 465 GLU O 254 REMARK 465 VAL O 255 REMARK 465 THR O 256 REMARK 465 CYS O 257 REMARK 465 VAL O 258 REMARK 465 VAL O 259 REMARK 465 VAL O 260 REMARK 465 ASP O 261 REMARK 465 VAL O 262 REMARK 465 SER O 263 REMARK 465 HIS O 264 REMARK 465 GLU O 265 REMARK 465 ASP O 266 REMARK 465 PRO O 267 REMARK 465 GLU O 268 REMARK 465 VAL O 269 REMARK 465 LYS O 270 REMARK 465 PHE O 271 REMARK 465 ASN O 272 REMARK 465 TRP O 273 REMARK 465 TYR O 274 REMARK 465 VAL O 275 REMARK 465 ASP O 276 REMARK 465 GLY O 277 REMARK 465 VAL O 278 REMARK 465 GLU O 279 REMARK 465 VAL O 280 REMARK 465 HIS O 281 REMARK 465 ASN O 282 REMARK 465 ALA O 283 REMARK 465 LYS O 284 REMARK 465 THR O 285 REMARK 465 LYS O 286 REMARK 465 PRO O 287 REMARK 465 ARG O 288 REMARK 465 GLU O 289 REMARK 465 GLU O 290 REMARK 465 GLN O 291 REMARK 465 TYR O 292 REMARK 465 ASN O 293 REMARK 465 SER O 294 REMARK 465 THR O 295 REMARK 465 TYR O 296 REMARK 465 ARG O 297 REMARK 465 VAL O 298 REMARK 465 VAL O 299 REMARK 465 SER O 300 REMARK 465 VAL O 301 REMARK 465 LEU O 302 REMARK 465 THR O 303 REMARK 465 VAL O 304 REMARK 465 LEU O 305 REMARK 465 HIS O 306 REMARK 465 GLN O 307 REMARK 465 ASP O 308 REMARK 465 TRP O 309 REMARK 465 LEU O 310 REMARK 465 ASN O 311 REMARK 465 GLY O 312 REMARK 465 LYS O 313 REMARK 465 GLU O 314 REMARK 465 TYR O 315 REMARK 465 LYS O 316 REMARK 465 CYS O 317 REMARK 465 LYS O 318 REMARK 465 VAL O 319 REMARK 465 SER O 320 REMARK 465 ASN O 321 REMARK 465 LYS O 322 REMARK 465 ALA O 323 REMARK 465 LEU O 324 REMARK 465 PRO O 325 REMARK 465 ALA O 326 REMARK 465 PRO O 327 REMARK 465 ILE O 328 REMARK 465 GLU O 329 REMARK 465 LYS O 330 REMARK 465 THR O 331 REMARK 465 ILE O 332 REMARK 465 SER O 333 REMARK 465 LYS O 334 REMARK 465 ALA O 335 REMARK 465 LYS O 336 REMARK 465 GLY O 337 REMARK 465 GLN O 338 REMARK 465 PRO O 339 REMARK 465 ARG O 340 REMARK 465 GLU O 341 REMARK 465 PRO O 342 REMARK 465 GLN O 343 REMARK 465 VAL O 344 REMARK 465 TYR O 345 REMARK 465 THR O 346 REMARK 465 LEU O 347 REMARK 465 PRO O 348 REMARK 465 PRO O 349 REMARK 465 SER O 350 REMARK 465 ARG O 351 REMARK 465 ASP O 352 REMARK 465 GLU O 353 REMARK 465 LEU O 354 REMARK 465 THR O 355 REMARK 465 LYS O 356 REMARK 465 ASN O 357 REMARK 465 GLN O 358 REMARK 465 VAL O 359 REMARK 465 SER O 360 REMARK 465 LEU O 361 REMARK 465 THR O 362 REMARK 465 CYS O 363 REMARK 465 LEU O 364 REMARK 465 VAL O 365 REMARK 465 LYS O 366 REMARK 465 GLY O 367 REMARK 465 PHE O 368 REMARK 465 TYR O 369 REMARK 465 PRO O 370 REMARK 465 SER O 371 REMARK 465 ASP O 372 REMARK 465 ILE O 373 REMARK 465 ALA O 374 REMARK 465 VAL O 375 REMARK 465 GLU O 376 REMARK 465 TRP O 377 REMARK 465 GLU O 378 REMARK 465 SER O 379 REMARK 465 ASN O 380 REMARK 465 GLY O 381 REMARK 465 GLN O 382 REMARK 465 PRO O 383 REMARK 465 GLU O 384 REMARK 465 ASN O 385 REMARK 465 ASN O 386 REMARK 465 TYR O 387 REMARK 465 LYS O 388 REMARK 465 THR O 389 REMARK 465 THR O 390 REMARK 465 PRO O 391 REMARK 465 PRO O 392 REMARK 465 VAL O 393 REMARK 465 LEU O 394 REMARK 465 ASP O 395 REMARK 465 SER O 396 REMARK 465 ASP O 397 REMARK 465 GLY O 398 REMARK 465 SER O 399 REMARK 465 PHE O 400 REMARK 465 PHE O 401 REMARK 465 LEU O 402 REMARK 465 TYR O 403 REMARK 465 SER O 404 REMARK 465 LYS O 405 REMARK 465 LEU O 406 REMARK 465 THR O 407 REMARK 465 VAL O 408 REMARK 465 ASP O 409 REMARK 465 LYS O 410 REMARK 465 SER O 411 REMARK 465 ARG O 412 REMARK 465 TRP O 413 REMARK 465 GLN O 414 REMARK 465 GLN O 415 REMARK 465 GLY O 416 REMARK 465 ASN O 417 REMARK 465 VAL O 418 REMARK 465 PHE O 419 REMARK 465 SER O 420 REMARK 465 CYS O 421 REMARK 465 SER O 422 REMARK 465 VAL O 423 REMARK 465 MET O 424 REMARK 465 HIS O 425 REMARK 465 GLU O 426 REMARK 465 ALA O 427 REMARK 465 LEU O 428 REMARK 465 HIS O 429 REMARK 465 ASN O 430 REMARK 465 HIS O 431 REMARK 465 TYR O 432 REMARK 465 THR O 433 REMARK 465 GLN O 434 REMARK 465 LYS O 435 REMARK 465 SER O 436 REMARK 465 LEU O 437 REMARK 465 SER O 438 REMARK 465 LEU O 439 REMARK 465 SER O 440 REMARK 465 PRO O 441 REMARK 465 GLY O 442 REMARK 465 GLN R 1 REMARK 465 SER R 2 REMARK 465 LEU R 107 REMARK 465 GLY R 108 REMARK 465 GLN R 109 REMARK 465 PRO R 110 REMARK 465 LYS R 111 REMARK 465 ALA R 112 REMARK 465 ASN R 113 REMARK 465 PRO R 114 REMARK 465 THR R 115 REMARK 465 VAL R 116 REMARK 465 THR R 117 REMARK 465 LEU R 118 REMARK 465 PHE R 119 REMARK 465 PRO R 120 REMARK 465 PRO R 121 REMARK 465 SER R 122 REMARK 465 SER R 123 REMARK 465 GLU R 124 REMARK 465 GLU R 125 REMARK 465 LEU R 126 REMARK 465 GLN R 127 REMARK 465 ALA R 128 REMARK 465 ASN R 129 REMARK 465 LYS R 130 REMARK 465 ALA R 131 REMARK 465 THR R 132 REMARK 465 LEU R 133 REMARK 465 VAL R 134 REMARK 465 CYS R 135 REMARK 465 LEU R 136 REMARK 465 ILE R 137 REMARK 465 SER R 138 REMARK 465 ASP R 139 REMARK 465 PHE R 140 REMARK 465 TYR R 141 REMARK 465 PRO R 142 REMARK 465 GLY R 143 REMARK 465 ALA R 144 REMARK 465 VAL R 145 REMARK 465 THR R 146 REMARK 465 VAL R 147 REMARK 465 ALA R 148 REMARK 465 TRP R 149 REMARK 465 LYS R 150 REMARK 465 ALA R 151 REMARK 465 ASP R 152 REMARK 465 GLY R 153 REMARK 465 SER R 154 REMARK 465 PRO R 155 REMARK 465 VAL R 156 REMARK 465 LYS R 157 REMARK 465 ALA R 158 REMARK 465 GLY R 159 REMARK 465 VAL R 160 REMARK 465 GLU R 161 REMARK 465 THR R 162 REMARK 465 THR R 163 REMARK 465 LYS R 164 REMARK 465 PRO R 165 REMARK 465 SER R 166 REMARK 465 LYS R 167 REMARK 465 GLN R 168 REMARK 465 SER R 169 REMARK 465 ASN R 170 REMARK 465 ASN R 171 REMARK 465 LYS R 172 REMARK 465 TYR R 173 REMARK 465 ALA R 174 REMARK 465 ALA R 175 REMARK 465 SER R 176 REMARK 465 SER R 177 REMARK 465 TYR R 178 REMARK 465 LEU R 179 REMARK 465 SER R 180 REMARK 465 LEU R 181 REMARK 465 THR R 182 REMARK 465 PRO R 183 REMARK 465 GLU R 184 REMARK 465 GLN R 185 REMARK 465 TRP R 186 REMARK 465 LYS R 187 REMARK 465 SER R 188 REMARK 465 HIS R 189 REMARK 465 ARG R 190 REMARK 465 SER R 191 REMARK 465 TYR R 192 REMARK 465 SER R 193 REMARK 465 CYS R 194 REMARK 465 GLN R 195 REMARK 465 VAL R 196 REMARK 465 THR R 197 REMARK 465 HIS R 198 REMARK 465 GLU R 199 REMARK 465 GLY R 200 REMARK 465 SER R 201 REMARK 465 THR R 202 REMARK 465 VAL R 203 REMARK 465 GLU R 204 REMARK 465 LYS R 205 REMARK 465 THR R 206 REMARK 465 VAL R 207 REMARK 465 ALA R 208 REMARK 465 PRO R 209 REMARK 465 THR R 210 REMARK 465 GLU R 211 REMARK 465 CYS R 212 REMARK 465 SER R 213 REMARK 465 ALA Q 114 REMARK 465 SER Q 115 REMARK 465 THR Q 116 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 LYS Q 129 REMARK 465 SER Q 130 REMARK 465 THR Q 131 REMARK 465 SER Q 132 REMARK 465 GLY Q 133 REMARK 465 GLY Q 134 REMARK 465 THR Q 135 REMARK 465 ALA Q 136 REMARK 465 ALA Q 137 REMARK 465 LEU Q 138 REMARK 465 GLY Q 139 REMARK 465 CYS Q 140 REMARK 465 LEU Q 141 REMARK 465 VAL Q 142 REMARK 465 LYS Q 143 REMARK 465 ASP Q 144 REMARK 465 TYR Q 145 REMARK 465 PHE Q 146 REMARK 465 PRO Q 147 REMARK 465 GLU Q 148 REMARK 465 PRO Q 149 REMARK 465 VAL Q 150 REMARK 465 THR Q 151 REMARK 465 VAL Q 152 REMARK 465 SER Q 153 REMARK 465 TRP Q 154 REMARK 465 ASN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ALA Q 158 REMARK 465 LEU Q 159 REMARK 465 THR Q 160 REMARK 465 SER Q 161 REMARK 465 GLY Q 162 REMARK 465 VAL Q 163 REMARK 465 HIS Q 164 REMARK 465 THR Q 165 REMARK 465 PHE Q 166 REMARK 465 PRO Q 167 REMARK 465 ALA Q 168 REMARK 465 VAL Q 169 REMARK 465 LEU Q 170 REMARK 465 GLN Q 171 REMARK 465 SER Q 172 REMARK 465 SER Q 173 REMARK 465 GLY Q 174 REMARK 465 LEU Q 175 REMARK 465 TYR Q 176 REMARK 465 SER Q 177 REMARK 465 LEU Q 178 REMARK 465 SER Q 179 REMARK 465 SER Q 180 REMARK 465 VAL Q 181 REMARK 465 VAL Q 182 REMARK 465 THR Q 183 REMARK 465 VAL Q 184 REMARK 465 PRO Q 185 REMARK 465 SER Q 186 REMARK 465 SER Q 187 REMARK 465 SER Q 188 REMARK 465 LEU Q 189 REMARK 465 GLY Q 190 REMARK 465 THR Q 191 REMARK 465 GLN Q 192 REMARK 465 THR Q 193 REMARK 465 TYR Q 194 REMARK 465 ILE Q 195 REMARK 465 CYS Q 196 REMARK 465 ASN Q 197 REMARK 465 VAL Q 198 REMARK 465 ASN Q 199 REMARK 465 HIS Q 200 REMARK 465 LYS Q 201 REMARK 465 PRO Q 202 REMARK 465 SER Q 203 REMARK 465 ASN Q 204 REMARK 465 THR Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 ASP Q 208 REMARK 465 LYS Q 209 REMARK 465 LYS Q 210 REMARK 465 VAL Q 211 REMARK 465 GLU Q 212 REMARK 465 PRO Q 213 REMARK 465 LYS Q 214 REMARK 465 SER Q 215 REMARK 465 CYS Q 216 REMARK 465 ASP Q 217 REMARK 465 LYS Q 218 REMARK 465 THR Q 219 REMARK 465 HIS Q 220 REMARK 465 THR Q 221 REMARK 465 CYS Q 222 REMARK 465 PRO Q 223 REMARK 465 PRO Q 224 REMARK 465 CYS Q 225 REMARK 465 PRO Q 226 REMARK 465 ALA Q 227 REMARK 465 PRO Q 228 REMARK 465 GLU Q 229 REMARK 465 LEU Q 230 REMARK 465 LEU Q 231 REMARK 465 GLY Q 232 REMARK 465 GLY Q 233 REMARK 465 PRO Q 234 REMARK 465 SER Q 235 REMARK 465 VAL Q 236 REMARK 465 PHE Q 237 REMARK 465 LEU Q 238 REMARK 465 PHE Q 239 REMARK 465 PRO Q 240 REMARK 465 PRO Q 241 REMARK 465 LYS Q 242 REMARK 465 PRO Q 243 REMARK 465 LYS Q 244 REMARK 465 ASP Q 245 REMARK 465 THR Q 246 REMARK 465 LEU Q 247 REMARK 465 MET Q 248 REMARK 465 ILE Q 249 REMARK 465 SER Q 250 REMARK 465 ARG Q 251 REMARK 465 THR Q 252 REMARK 465 PRO Q 253 REMARK 465 GLU Q 254 REMARK 465 VAL Q 255 REMARK 465 THR Q 256 REMARK 465 CYS Q 257 REMARK 465 VAL Q 258 REMARK 465 VAL Q 259 REMARK 465 VAL Q 260 REMARK 465 ASP Q 261 REMARK 465 VAL Q 262 REMARK 465 SER Q 263 REMARK 465 HIS Q 264 REMARK 465 GLU Q 265 REMARK 465 ASP Q 266 REMARK 465 PRO Q 267 REMARK 465 GLU Q 268 REMARK 465 VAL Q 269 REMARK 465 LYS Q 270 REMARK 465 PHE Q 271 REMARK 465 ASN Q 272 REMARK 465 TRP Q 273 REMARK 465 TYR Q 274 REMARK 465 VAL Q 275 REMARK 465 ASP Q 276 REMARK 465 GLY Q 277 REMARK 465 VAL Q 278 REMARK 465 GLU Q 279 REMARK 465 VAL Q 280 REMARK 465 HIS Q 281 REMARK 465 ASN Q 282 REMARK 465 ALA Q 283 REMARK 465 LYS Q 284 REMARK 465 THR Q 285 REMARK 465 LYS Q 286 REMARK 465 PRO Q 287 REMARK 465 ARG Q 288 REMARK 465 GLU Q 289 REMARK 465 GLU Q 290 REMARK 465 GLN Q 291 REMARK 465 TYR Q 292 REMARK 465 ASN Q 293 REMARK 465 SER Q 294 REMARK 465 THR Q 295 REMARK 465 TYR Q 296 REMARK 465 ARG Q 297 REMARK 465 VAL Q 298 REMARK 465 VAL Q 299 REMARK 465 SER Q 300 REMARK 465 VAL Q 301 REMARK 465 LEU Q 302 REMARK 465 THR Q 303 REMARK 465 VAL Q 304 REMARK 465 LEU Q 305 REMARK 465 HIS Q 306 REMARK 465 GLN Q 307 REMARK 465 ASP Q 308 REMARK 465 TRP Q 309 REMARK 465 LEU Q 310 REMARK 465 ASN Q 311 REMARK 465 GLY Q 312 REMARK 465 LYS Q 313 REMARK 465 GLU Q 314 REMARK 465 TYR Q 315 REMARK 465 LYS Q 316 REMARK 465 CYS Q 317 REMARK 465 LYS Q 318 REMARK 465 VAL Q 319 REMARK 465 SER Q 320 REMARK 465 ASN Q 321 REMARK 465 LYS Q 322 REMARK 465 ALA Q 323 REMARK 465 LEU Q 324 REMARK 465 PRO Q 325 REMARK 465 ALA Q 326 REMARK 465 PRO Q 327 REMARK 465 ILE Q 328 REMARK 465 GLU Q 329 REMARK 465 LYS Q 330 REMARK 465 THR Q 331 REMARK 465 ILE Q 332 REMARK 465 SER Q 333 REMARK 465 LYS Q 334 REMARK 465 ALA Q 335 REMARK 465 LYS Q 336 REMARK 465 GLY Q 337 REMARK 465 GLN Q 338 REMARK 465 PRO Q 339 REMARK 465 ARG Q 340 REMARK 465 GLU Q 341 REMARK 465 PRO Q 342 REMARK 465 GLN Q 343 REMARK 465 VAL Q 344 REMARK 465 TYR Q 345 REMARK 465 THR Q 346 REMARK 465 LEU Q 347 REMARK 465 PRO Q 348 REMARK 465 PRO Q 349 REMARK 465 SER Q 350 REMARK 465 ARG Q 351 REMARK 465 ASP Q 352 REMARK 465 GLU Q 353 REMARK 465 LEU Q 354 REMARK 465 THR Q 355 REMARK 465 LYS Q 356 REMARK 465 ASN Q 357 REMARK 465 GLN Q 358 REMARK 465 VAL Q 359 REMARK 465 SER Q 360 REMARK 465 LEU Q 361 REMARK 465 THR Q 362 REMARK 465 CYS Q 363 REMARK 465 LEU Q 364 REMARK 465 VAL Q 365 REMARK 465 LYS Q 366 REMARK 465 GLY Q 367 REMARK 465 PHE Q 368 REMARK 465 TYR Q 369 REMARK 465 PRO Q 370 REMARK 465 SER Q 371 REMARK 465 ASP Q 372 REMARK 465 ILE Q 373 REMARK 465 ALA Q 374 REMARK 465 VAL Q 375 REMARK 465 GLU Q 376 REMARK 465 TRP Q 377 REMARK 465 GLU Q 378 REMARK 465 SER Q 379 REMARK 465 ASN Q 380 REMARK 465 GLY Q 381 REMARK 465 GLN Q 382 REMARK 465 PRO Q 383 REMARK 465 GLU Q 384 REMARK 465 ASN Q 385 REMARK 465 ASN Q 386 REMARK 465 TYR Q 387 REMARK 465 LYS Q 388 REMARK 465 THR Q 389 REMARK 465 THR Q 390 REMARK 465 PRO Q 391 REMARK 465 PRO Q 392 REMARK 465 VAL Q 393 REMARK 465 LEU Q 394 REMARK 465 ASP Q 395 REMARK 465 SER Q 396 REMARK 465 ASP Q 397 REMARK 465 GLY Q 398 REMARK 465 SER Q 399 REMARK 465 PHE Q 400 REMARK 465 PHE Q 401 REMARK 465 LEU Q 402 REMARK 465 TYR Q 403 REMARK 465 SER Q 404 REMARK 465 LYS Q 405 REMARK 465 LEU Q 406 REMARK 465 THR Q 407 REMARK 465 VAL Q 408 REMARK 465 ASP Q 409 REMARK 465 LYS Q 410 REMARK 465 SER Q 411 REMARK 465 ARG Q 412 REMARK 465 TRP Q 413 REMARK 465 GLN Q 414 REMARK 465 GLN Q 415 REMARK 465 GLY Q 416 REMARK 465 ASN Q 417 REMARK 465 VAL Q 418 REMARK 465 PHE Q 419 REMARK 465 SER Q 420 REMARK 465 CYS Q 421 REMARK 465 SER Q 422 REMARK 465 VAL Q 423 REMARK 465 MET Q 424 REMARK 465 HIS Q 425 REMARK 465 GLU Q 426 REMARK 465 ALA Q 427 REMARK 465 LEU Q 428 REMARK 465 HIS Q 429 REMARK 465 ASN Q 430 REMARK 465 HIS Q 431 REMARK 465 TYR Q 432 REMARK 465 THR Q 433 REMARK 465 GLN Q 434 REMARK 465 LYS Q 435 REMARK 465 SER Q 436 REMARK 465 LEU Q 437 REMARK 465 SER Q 438 REMARK 465 LEU Q 439 REMARK 465 SER Q 440 REMARK 465 PRO Q 441 REMARK 465 GLY Q 442 REMARK 465 GLN T 1 REMARK 465 SER T 2 REMARK 465 LEU T 107 REMARK 465 GLY T 108 REMARK 465 GLN T 109 REMARK 465 PRO T 110 REMARK 465 LYS T 111 REMARK 465 ALA T 112 REMARK 465 ASN T 113 REMARK 465 PRO T 114 REMARK 465 THR T 115 REMARK 465 VAL T 116 REMARK 465 THR T 117 REMARK 465 LEU T 118 REMARK 465 PHE T 119 REMARK 465 PRO T 120 REMARK 465 PRO T 121 REMARK 465 SER T 122 REMARK 465 SER T 123 REMARK 465 GLU T 124 REMARK 465 GLU T 125 REMARK 465 LEU T 126 REMARK 465 GLN T 127 REMARK 465 ALA T 128 REMARK 465 ASN T 129 REMARK 465 LYS T 130 REMARK 465 ALA T 131 REMARK 465 THR T 132 REMARK 465 LEU T 133 REMARK 465 VAL T 134 REMARK 465 CYS T 135 REMARK 465 LEU T 136 REMARK 465 ILE T 137 REMARK 465 SER T 138 REMARK 465 ASP T 139 REMARK 465 PHE T 140 REMARK 465 TYR T 141 REMARK 465 PRO T 142 REMARK 465 GLY T 143 REMARK 465 ALA T 144 REMARK 465 VAL T 145 REMARK 465 THR T 146 REMARK 465 VAL T 147 REMARK 465 ALA T 148 REMARK 465 TRP T 149 REMARK 465 LYS T 150 REMARK 465 ALA T 151 REMARK 465 ASP T 152 REMARK 465 GLY T 153 REMARK 465 SER T 154 REMARK 465 PRO T 155 REMARK 465 VAL T 156 REMARK 465 LYS T 157 REMARK 465 ALA T 158 REMARK 465 GLY T 159 REMARK 465 VAL T 160 REMARK 465 GLU T 161 REMARK 465 THR T 162 REMARK 465 THR T 163 REMARK 465 LYS T 164 REMARK 465 PRO T 165 REMARK 465 SER T 166 REMARK 465 LYS T 167 REMARK 465 GLN T 168 REMARK 465 SER T 169 REMARK 465 ASN T 170 REMARK 465 ASN T 171 REMARK 465 LYS T 172 REMARK 465 TYR T 173 REMARK 465 ALA T 174 REMARK 465 ALA T 175 REMARK 465 SER T 176 REMARK 465 SER T 177 REMARK 465 TYR T 178 REMARK 465 LEU T 179 REMARK 465 SER T 180 REMARK 465 LEU T 181 REMARK 465 THR T 182 REMARK 465 PRO T 183 REMARK 465 GLU T 184 REMARK 465 GLN T 185 REMARK 465 TRP T 186 REMARK 465 LYS T 187 REMARK 465 SER T 188 REMARK 465 HIS T 189 REMARK 465 ARG T 190 REMARK 465 SER T 191 REMARK 465 TYR T 192 REMARK 465 SER T 193 REMARK 465 CYS T 194 REMARK 465 GLN T 195 REMARK 465 VAL T 196 REMARK 465 THR T 197 REMARK 465 HIS T 198 REMARK 465 GLU T 199 REMARK 465 GLY T 200 REMARK 465 SER T 201 REMARK 465 THR T 202 REMARK 465 VAL T 203 REMARK 465 GLU T 204 REMARK 465 LYS T 205 REMARK 465 THR T 206 REMARK 465 VAL T 207 REMARK 465 ALA T 208 REMARK 465 PRO T 209 REMARK 465 THR T 210 REMARK 465 GLU T 211 REMARK 465 CYS T 212 REMARK 465 SER T 213 REMARK 465 ALA S 114 REMARK 465 SER S 115 REMARK 465 THR S 116 REMARK 465 LYS S 117 REMARK 465 GLY S 118 REMARK 465 PRO S 119 REMARK 465 SER S 120 REMARK 465 VAL S 121 REMARK 465 PHE S 122 REMARK 465 PRO S 123 REMARK 465 LEU S 124 REMARK 465 ALA S 125 REMARK 465 PRO S 126 REMARK 465 SER S 127 REMARK 465 SER S 128 REMARK 465 LYS S 129 REMARK 465 SER S 130 REMARK 465 THR S 131 REMARK 465 SER S 132 REMARK 465 GLY S 133 REMARK 465 GLY S 134 REMARK 465 THR S 135 REMARK 465 ALA S 136 REMARK 465 ALA S 137 REMARK 465 LEU S 138 REMARK 465 GLY S 139 REMARK 465 CYS S 140 REMARK 465 LEU S 141 REMARK 465 VAL S 142 REMARK 465 LYS S 143 REMARK 465 ASP S 144 REMARK 465 TYR S 145 REMARK 465 PHE S 146 REMARK 465 PRO S 147 REMARK 465 GLU S 148 REMARK 465 PRO S 149 REMARK 465 VAL S 150 REMARK 465 THR S 151 REMARK 465 VAL S 152 REMARK 465 SER S 153 REMARK 465 TRP S 154 REMARK 465 ASN S 155 REMARK 465 SER S 156 REMARK 465 GLY S 157 REMARK 465 ALA S 158 REMARK 465 LEU S 159 REMARK 465 THR S 160 REMARK 465 SER S 161 REMARK 465 GLY S 162 REMARK 465 VAL S 163 REMARK 465 HIS S 164 REMARK 465 THR S 165 REMARK 465 PHE S 166 REMARK 465 PRO S 167 REMARK 465 ALA S 168 REMARK 465 VAL S 169 REMARK 465 LEU S 170 REMARK 465 GLN S 171 REMARK 465 SER S 172 REMARK 465 SER S 173 REMARK 465 GLY S 174 REMARK 465 LEU S 175 REMARK 465 TYR S 176 REMARK 465 SER S 177 REMARK 465 LEU S 178 REMARK 465 SER S 179 REMARK 465 SER S 180 REMARK 465 VAL S 181 REMARK 465 VAL S 182 REMARK 465 THR S 183 REMARK 465 VAL S 184 REMARK 465 PRO S 185 REMARK 465 SER S 186 REMARK 465 SER S 187 REMARK 465 SER S 188 REMARK 465 LEU S 189 REMARK 465 GLY S 190 REMARK 465 THR S 191 REMARK 465 GLN S 192 REMARK 465 THR S 193 REMARK 465 TYR S 194 REMARK 465 ILE S 195 REMARK 465 CYS S 196 REMARK 465 ASN S 197 REMARK 465 VAL S 198 REMARK 465 ASN S 199 REMARK 465 HIS S 200 REMARK 465 LYS S 201 REMARK 465 PRO S 202 REMARK 465 SER S 203 REMARK 465 ASN S 204 REMARK 465 THR S 205 REMARK 465 LYS S 206 REMARK 465 VAL S 207 REMARK 465 ASP S 208 REMARK 465 LYS S 209 REMARK 465 LYS S 210 REMARK 465 VAL S 211 REMARK 465 GLU S 212 REMARK 465 PRO S 213 REMARK 465 LYS S 214 REMARK 465 SER S 215 REMARK 465 CYS S 216 REMARK 465 ASP S 217 REMARK 465 LYS S 218 REMARK 465 THR S 219 REMARK 465 HIS S 220 REMARK 465 THR S 221 REMARK 465 CYS S 222 REMARK 465 PRO S 223 REMARK 465 PRO S 224 REMARK 465 CYS S 225 REMARK 465 PRO S 226 REMARK 465 ALA S 227 REMARK 465 PRO S 228 REMARK 465 GLU S 229 REMARK 465 LEU S 230 REMARK 465 LEU S 231 REMARK 465 GLY S 232 REMARK 465 GLY S 233 REMARK 465 PRO S 234 REMARK 465 SER S 235 REMARK 465 VAL S 236 REMARK 465 PHE S 237 REMARK 465 LEU S 238 REMARK 465 PHE S 239 REMARK 465 PRO S 240 REMARK 465 PRO S 241 REMARK 465 LYS S 242 REMARK 465 PRO S 243 REMARK 465 LYS S 244 REMARK 465 ASP S 245 REMARK 465 THR S 246 REMARK 465 LEU S 247 REMARK 465 MET S 248 REMARK 465 ILE S 249 REMARK 465 SER S 250 REMARK 465 ARG S 251 REMARK 465 THR S 252 REMARK 465 PRO S 253 REMARK 465 GLU S 254 REMARK 465 VAL S 255 REMARK 465 THR S 256 REMARK 465 CYS S 257 REMARK 465 VAL S 258 REMARK 465 VAL S 259 REMARK 465 VAL S 260 REMARK 465 ASP S 261 REMARK 465 VAL S 262 REMARK 465 SER S 263 REMARK 465 HIS S 264 REMARK 465 GLU S 265 REMARK 465 ASP S 266 REMARK 465 PRO S 267 REMARK 465 GLU S 268 REMARK 465 VAL S 269 REMARK 465 LYS S 270 REMARK 465 PHE S 271 REMARK 465 ASN S 272 REMARK 465 TRP S 273 REMARK 465 TYR S 274 REMARK 465 VAL S 275 REMARK 465 ASP S 276 REMARK 465 GLY S 277 REMARK 465 VAL S 278 REMARK 465 GLU S 279 REMARK 465 VAL S 280 REMARK 465 HIS S 281 REMARK 465 ASN S 282 REMARK 465 ALA S 283 REMARK 465 LYS S 284 REMARK 465 THR S 285 REMARK 465 LYS S 286 REMARK 465 PRO S 287 REMARK 465 ARG S 288 REMARK 465 GLU S 289 REMARK 465 GLU S 290 REMARK 465 GLN S 291 REMARK 465 TYR S 292 REMARK 465 ASN S 293 REMARK 465 SER S 294 REMARK 465 THR S 295 REMARK 465 TYR S 296 REMARK 465 ARG S 297 REMARK 465 VAL S 298 REMARK 465 VAL S 299 REMARK 465 SER S 300 REMARK 465 VAL S 301 REMARK 465 LEU S 302 REMARK 465 THR S 303 REMARK 465 VAL S 304 REMARK 465 LEU S 305 REMARK 465 HIS S 306 REMARK 465 GLN S 307 REMARK 465 ASP S 308 REMARK 465 TRP S 309 REMARK 465 LEU S 310 REMARK 465 ASN S 311 REMARK 465 GLY S 312 REMARK 465 LYS S 313 REMARK 465 GLU S 314 REMARK 465 TYR S 315 REMARK 465 LYS S 316 REMARK 465 CYS S 317 REMARK 465 LYS S 318 REMARK 465 VAL S 319 REMARK 465 SER S 320 REMARK 465 ASN S 321 REMARK 465 LYS S 322 REMARK 465 ALA S 323 REMARK 465 LEU S 324 REMARK 465 PRO S 325 REMARK 465 ALA S 326 REMARK 465 PRO S 327 REMARK 465 ILE S 328 REMARK 465 GLU S 329 REMARK 465 LYS S 330 REMARK 465 THR S 331 REMARK 465 ILE S 332 REMARK 465 SER S 333 REMARK 465 LYS S 334 REMARK 465 ALA S 335 REMARK 465 LYS S 336 REMARK 465 GLY S 337 REMARK 465 GLN S 338 REMARK 465 PRO S 339 REMARK 465 ARG S 340 REMARK 465 GLU S 341 REMARK 465 PRO S 342 REMARK 465 GLN S 343 REMARK 465 VAL S 344 REMARK 465 TYR S 345 REMARK 465 THR S 346 REMARK 465 LEU S 347 REMARK 465 PRO S 348 REMARK 465 PRO S 349 REMARK 465 SER S 350 REMARK 465 ARG S 351 REMARK 465 ASP S 352 REMARK 465 GLU S 353 REMARK 465 LEU S 354 REMARK 465 THR S 355 REMARK 465 LYS S 356 REMARK 465 ASN S 357 REMARK 465 GLN S 358 REMARK 465 VAL S 359 REMARK 465 SER S 360 REMARK 465 LEU S 361 REMARK 465 THR S 362 REMARK 465 CYS S 363 REMARK 465 LEU S 364 REMARK 465 VAL S 365 REMARK 465 LYS S 366 REMARK 465 GLY S 367 REMARK 465 PHE S 368 REMARK 465 TYR S 369 REMARK 465 PRO S 370 REMARK 465 SER S 371 REMARK 465 ASP S 372 REMARK 465 ILE S 373 REMARK 465 ALA S 374 REMARK 465 VAL S 375 REMARK 465 GLU S 376 REMARK 465 TRP S 377 REMARK 465 GLU S 378 REMARK 465 SER S 379 REMARK 465 ASN S 380 REMARK 465 GLY S 381 REMARK 465 GLN S 382 REMARK 465 PRO S 383 REMARK 465 GLU S 384 REMARK 465 ASN S 385 REMARK 465 ASN S 386 REMARK 465 TYR S 387 REMARK 465 LYS S 388 REMARK 465 THR S 389 REMARK 465 THR S 390 REMARK 465 PRO S 391 REMARK 465 PRO S 392 REMARK 465 VAL S 393 REMARK 465 LEU S 394 REMARK 465 ASP S 395 REMARK 465 SER S 396 REMARK 465 ASP S 397 REMARK 465 GLY S 398 REMARK 465 SER S 399 REMARK 465 PHE S 400 REMARK 465 PHE S 401 REMARK 465 LEU S 402 REMARK 465 TYR S 403 REMARK 465 SER S 404 REMARK 465 LYS S 405 REMARK 465 LEU S 406 REMARK 465 THR S 407 REMARK 465 VAL S 408 REMARK 465 ASP S 409 REMARK 465 LYS S 410 REMARK 465 SER S 411 REMARK 465 ARG S 412 REMARK 465 TRP S 413 REMARK 465 GLN S 414 REMARK 465 GLN S 415 REMARK 465 GLY S 416 REMARK 465 ASN S 417 REMARK 465 VAL S 418 REMARK 465 PHE S 419 REMARK 465 SER S 420 REMARK 465 CYS S 421 REMARK 465 SER S 422 REMARK 465 VAL S 423 REMARK 465 MET S 424 REMARK 465 HIS S 425 REMARK 465 GLU S 426 REMARK 465 ALA S 427 REMARK 465 LEU S 428 REMARK 465 HIS S 429 REMARK 465 ASN S 430 REMARK 465 HIS S 431 REMARK 465 TYR S 432 REMARK 465 THR S 433 REMARK 465 GLN S 434 REMARK 465 LYS S 435 REMARK 465 SER S 436 REMARK 465 LEU S 437 REMARK 465 SER S 438 REMARK 465 LEU S 439 REMARK 465 SER S 440 REMARK 465 PRO S 441 REMARK 465 GLY S 442 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 ND2 ASN I 3 O TYR A 100C 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PRO I 6 53.48 -96.15 REMARK 500 ASN I 9 73.73 53.47 REMARK 500 ASN J 9 71.87 53.11 REMARK 500 PRO J 10 47.95 -72.89 REMARK 500 ASN L 27B -63.02 -94.71 REMARK 500 THR L 42 75.98 48.76 REMARK 500 ALA L 43 142.45 -36.80 REMARK 500 GLN L 89 144.69 -173.14 REMARK 500 SER L 90 -162.01 -165.93 REMARK 500 ARG H 75 26.64 -140.60 REMARK 500 ALA B 43 140.90 -36.46 REMARK 500 SER B 90 -166.17 -162.81 REMARK 500 VAL A 48 -57.40 -120.01 REMARK 500 ARG A 75 23.63 -140.45 REMARK 500 ASP A 86 48.51 -85.13 REMARK 500 ALA A 88 -178.83 -173.33 REMARK 500 ASN D 27B -62.09 -94.26 REMARK 500 THR D 42 72.04 48.29 REMARK 500 ALA D 43 141.45 -36.75 REMARK 500 GLN D 89 142.44 -171.02 REMARK 500 SER D 90 -167.23 -166.57 REMARK 500 VAL C 48 -51.33 -122.66 REMARK 500 ARG C 75 28.66 -140.84 REMARK 500 ASN F 27B -61.91 -97.54 REMARK 500 THR F 42 70.04 48.36 REMARK 500 ALA F 43 136.93 -35.71 REMARK 500 VAL E 48 -57.39 -120.87 REMARK 500 ASP E 86 47.13 -80.40 REMARK 500 ASN N 27B -61.98 -97.51 REMARK 500 ALA N 43 136.93 -35.62 REMARK 500 VAL M 48 -57.31 -120.91 REMARK 500 ASP M 86 47.64 -86.22 REMARK 500 ASN P 27B -63.13 -94.48 REMARK 500 THR P 42 71.97 48.31 REMARK 500 ALA P 43 141.35 -36.64 REMARK 500 GLN P 89 143.40 -171.91 REMARK 500 SER P 90 -168.50 -168.06 REMARK 500 VAL O 48 -51.41 -122.59 REMARK 500 ARG O 75 28.35 -141.02 REMARK 500 ASN R 27B -62.95 -94.17 REMARK 500 THR R 42 76.09 48.72 REMARK 500 ALA R 43 142.51 -36.81 REMARK 500 GLN R 89 145.46 -173.97 REMARK 500 SER R 90 -163.27 -168.65 REMARK 500 ARG Q 75 25.09 -140.67 REMARK 500 ASP Q 86 49.93 -83.20 REMARK 500 ALA T 43 140.94 -36.49 REMARK 500 SER T 90 -166.06 -161.79 REMARK 500 VAL S 48 -57.17 -120.18 REMARK 500 ARG S 75 23.63 -140.42 REMARK 500 REMARK 500 THIS ENTRY HAS 52 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-27781 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF 227 FAB IN COMPLEX WITH (NPNA)8 PEPTIDE DBREF 8DYT I 1 32 UNP Q5R2L4 Q5R2L4_PLAFA 150 181 DBREF 8DYT J 1 32 UNP Q5R2L4 Q5R2L4_PLAFA 150 181 DBREF 8DYT L 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT H 1 442 PDB 8DYT 8DYT 1 442 DBREF 8DYT B 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT A 1 442 PDB 8DYT 8DYT 1 442 DBREF 8DYT D 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT C 1 442 PDB 8DYT 8DYT 1 442 DBREF 8DYT F 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT E 1 442 PDB 8DYT 8DYT 1 442 DBREF 8DYT N 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT M 1 442 PDB 8DYT 8DYT 1 442 DBREF 8DYT P 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT O 1 442 PDB 8DYT 8DYT 1 442 DBREF 8DYT R 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT Q 1 442 PDB 8DYT 8DYT 1 442 DBREF 8DYT T 1 213 PDB 8DYT 8DYT 1 213 DBREF 8DYT S 1 442 PDB 8DYT 8DYT 1 442 SEQRES 1 I 32 ASN PRO ASN ALA ASN PRO ASN ALA ASN PRO ASN ALA ASN SEQRES 2 I 32 PRO ASN ALA ASN PRO ASN ALA ASN PRO ASN ALA ASN PRO SEQRES 3 I 32 ASN ALA ASN PRO ASN ALA SEQRES 1 J 32 ASN PRO ASN ALA ASN PRO ASN ALA ASN PRO ASN ALA ASN SEQRES 2 J 32 PRO ASN ALA ASN PRO ASN ALA ASN PRO ASN ALA ASN PRO SEQRES 3 J 32 ASN ALA ASN PRO ASN ALA SEQRES 1 L 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 L 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 L 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 L 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 L 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 L 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 L 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 L 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 L 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 L 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 L 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 L 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 L 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 L 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 L 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 L 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 L 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 H 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 H 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 H 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 H 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 H 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 H 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 H 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 H 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 H 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 H 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 H 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 H 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 H 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 H 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 H 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 H 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 H 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 H 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 H 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 H 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 H 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 H 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 H 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 H 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 H 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 H 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 H 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 H 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 H 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 H 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 H 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 H 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 H 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 H 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 H 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY SEQRES 1 B 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 B 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 B 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 B 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 B 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 B 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 B 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 B 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 B 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 B 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 B 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 B 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 B 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 B 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 B 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 B 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 B 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 A 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 A 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 A 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 A 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 A 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 A 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 A 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 A 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 A 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 A 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 A 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 A 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 A 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 A 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 A 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 A 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 A 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 A 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 A 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 A 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 A 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 A 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 A 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 A 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 A 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 A 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 A 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 A 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 A 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 A 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 A 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 A 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 A 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 A 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 A 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY SEQRES 1 D 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 D 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 D 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 D 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 D 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 D 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 D 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 D 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 D 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 D 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 D 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 D 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 D 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 D 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 D 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 D 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 D 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 C 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 C 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 C 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 C 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 C 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 C 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 C 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 C 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 C 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 C 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 C 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 C 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 C 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 C 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 C 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 C 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 C 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 C 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 C 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 C 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 C 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 C 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 C 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 C 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 C 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 C 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 C 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 C 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 C 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 C 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 C 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 C 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 C 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 C 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 C 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY SEQRES 1 F 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 F 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 F 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 F 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 F 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 F 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 F 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 F 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 F 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 F 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 F 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 F 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 F 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 F 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 F 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 F 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 F 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 E 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 E 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 E 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 E 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 E 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 E 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 E 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 E 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 E 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 E 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 E 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 E 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 E 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 E 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 E 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 E 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 E 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 E 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 E 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 E 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 E 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 E 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 E 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 E 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 E 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 E 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 E 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 E 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 E 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 E 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 E 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 E 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 E 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 E 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 E 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY SEQRES 1 N 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 N 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 N 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 N 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 N 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 N 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 N 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 N 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 N 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 N 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 N 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 N 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 N 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 N 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 N 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 N 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 N 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 M 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 M 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 M 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 M 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 M 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 M 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 M 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 M 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 M 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 M 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 M 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 M 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 M 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 M 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 M 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 M 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 M 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 M 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 M 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 M 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 M 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 M 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 M 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 M 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 M 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 M 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 M 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 M 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 M 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 M 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 M 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 M 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 M 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 M 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 M 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY SEQRES 1 P 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 P 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 P 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 P 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 P 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 P 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 P 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 P 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 P 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 P 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 P 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 P 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 P 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 P 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 P 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 P 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 P 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 O 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 O 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 O 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 O 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 O 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 O 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 O 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 O 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 O 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 O 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 O 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 O 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 O 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 O 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 O 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 O 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 O 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 O 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 O 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 O 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 O 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 O 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 O 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 O 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 O 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 O 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 O 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 O 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 O 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 O 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 O 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 O 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 O 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 O 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 O 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY SEQRES 1 R 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 R 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 R 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 R 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 R 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 R 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 R 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 R 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 R 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 R 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 R 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 R 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 R 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 R 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 R 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 R 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 R 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 Q 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 Q 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 Q 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 Q 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 Q 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 Q 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 Q 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 Q 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 Q 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 Q 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 Q 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 Q 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 Q 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 Q 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 Q 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 Q 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 Q 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 Q 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 Q 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 Q 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 Q 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 Q 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 Q 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 Q 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 Q 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 Q 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 Q 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 Q 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 Q 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 Q 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 Q 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 Q 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 Q 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 Q 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 Q 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY SEQRES 1 T 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 T 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 T 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 T 217 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 T 217 ASN GLY ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 T 217 GLY SER LYS SER GLY THR SER VAL SER LEU ALA ILE THR SEQRES 7 T 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 T 217 SER TYR ASP SER SER LEU SER ALA PHE VAL PHE GLY THR SEQRES 9 T 217 GLY THR LYS VAL THR VAL LEU GLY GLN PRO LYS ALA ASN SEQRES 10 T 217 PRO THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 T 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 T 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 T 217 GLY SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SEQRES 14 T 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 T 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 T 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 T 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 S 453 GLN VAL GLN LEU VAL GLN SER GLY GLY GLY VAL VAL GLN SEQRES 2 S 453 PRO GLY ARG SER LEU ARG LEU SER CYS VAL THR SER GLY SEQRES 3 S 453 PHE THR PHE PRO ALA PHE GLY MET HIS TRP VAL ARG GLN SEQRES 4 S 453 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE TRP SEQRES 5 S 453 TYR ASP GLY SER LYS LYS TYR TYR ALA ASP SER VAL ARG SEQRES 6 S 453 GLY ARG PHE THR ILE SER ARG ASP ASN SER ARG ASN THR SEQRES 7 S 453 LEU TYR LEU GLN MET HIS SER LEU ARG ALA GLU ASP THR SEQRES 8 S 453 ALA VAL TYR TYR CYS ALA ARG VAL LYS ASN TYR GLU SER SEQRES 9 S 453 SER GLY TYR SER GLN CYS LEU ASP TYR TRP GLY GLN GLY SEQRES 10 S 453 VAL LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SEQRES 11 S 453 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 S 453 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 S 453 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 S 453 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 S 453 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 S 453 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 S 453 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 S 453 VAL GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO SEQRES 19 S 453 PRO CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL SEQRES 20 S 453 PHE LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SEQRES 21 S 453 SER ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SEQRES 22 S 453 SER HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL SEQRES 23 S 453 ASP GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG SEQRES 24 S 453 GLU GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL SEQRES 25 S 453 LEU THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU SEQRES 26 S 453 TYR LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO SEQRES 27 S 453 ILE GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG SEQRES 28 S 453 GLU PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU SEQRES 29 S 453 LEU THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS SEQRES 30 S 453 GLY PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER SEQRES 31 S 453 ASN GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO SEQRES 32 S 453 VAL LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS SEQRES 33 S 453 LEU THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL SEQRES 34 S 453 PHE SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS SEQRES 35 S 453 TYR THR GLN LYS SER LEU SER LEU SER PRO GLY HELIX 1 AA1 GLN L 79 GLU L 83 5 5 HELIX 2 AA2 THR H 28 PHE H 32 5 5 HELIX 3 AA3 ASP H 61 ARG H 64 5 4 HELIX 4 AA4 ASN H 73 ARG H 75 5 3 HELIX 5 AA5 GLN B 79 GLU B 83 5 5 HELIX 6 AA6 THR A 28 PHE A 32 5 5 HELIX 7 AA7 GLN D 79 GLU D 83 5 5 HELIX 8 AA8 THR C 28 PHE C 32 5 5 HELIX 9 AA9 ASP C 61 ARG C 64 5 4 HELIX 10 AB1 ASN C 73 ARG C 75 5 3 HELIX 11 AB2 GLN F 79 GLU F 83 5 5 HELIX 12 AB3 THR E 28 PHE E 32 5 5 HELIX 13 AB4 GLN N 79 GLU N 83 5 5 HELIX 14 AB5 THR M 28 PHE M 32 5 5 HELIX 15 AB6 GLN P 79 GLU P 83 5 5 HELIX 16 AB7 THR O 28 PHE O 32 5 5 HELIX 17 AB8 ASP O 61 ARG O 64 5 4 HELIX 18 AB9 ASN O 73 ARG O 75 5 3 HELIX 19 AC1 GLN R 79 GLU R 83 5 5 HELIX 20 AC2 THR Q 28 PHE Q 32 5 5 HELIX 21 AC3 ASP Q 61 ARG Q 64 5 4 HELIX 22 AC4 ASN Q 73 ARG Q 75 5 3 HELIX 23 AC5 GLN T 79 GLU T 83 5 5 HELIX 24 AC6 THR S 28 PHE S 32 5 5 SHEET 1 AA1 5 SER L 9 VAL L 11 0 SHEET 2 AA1 5 THR L 102 VAL L 104 1 O LYS L 103 N VAL L 11 SHEET 3 AA1 5 ASP L 85 TYR L 87 -1 N TYR L 86 O THR L 102 SHEET 4 AA1 5 TRP L 35 GLN L 38 -1 N GLN L 38 O ASP L 85 SHEET 5 AA1 5 LYS L 45 ILE L 48 -1 O ILE L 48 N TRP L 35 SHEET 1 AA2 3 VAL L 19 THR L 24 0 SHEET 2 AA2 3 SER L 70 ILE L 75 -1 O ILE L 75 N VAL L 19 SHEET 3 AA2 3 PHE L 62 SER L 67 -1 N SER L 67 O SER L 70 SHEET 1 AA3 2 GLN L 89 ASP L 92 0 SHEET 2 AA3 2 ALA L 95B PHE L 98 -1 O VAL L 97 N SER L 90 SHEET 1 AA4 4 GLN H 3 SER H 7 0 SHEET 2 AA4 4 LEU H 18 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AA4 4 THR H 77 MET H 82 -1 O MET H 82 N LEU H 18 SHEET 4 AA4 4 PHE H 67 ASP H 72 -1 N THR H 68 O GLN H 81 SHEET 1 AA5 6 GLY H 10 VAL H 12 0 SHEET 2 AA5 6 VAL H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AA5 6 ALA H 88 VAL H 95 -1 N TYR H 90 O VAL H 107 SHEET 4 AA5 6 MET H 34 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AA5 6 LEU H 45 ILE H 51 -1 O GLU H 46 N ARG H 38 SHEET 6 AA5 6 LYS H 57 TYR H 59 -1 O TYR H 58 N VAL H 50 SHEET 1 AA6 4 GLY H 10 VAL H 12 0 SHEET 2 AA6 4 VAL H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AA6 4 ALA H 88 VAL H 95 -1 N TYR H 90 O VAL H 107 SHEET 4 AA6 4 LEU H 100G TRP H 103 -1 O ASP H 101 N ARG H 94 SHEET 1 AA7 5 SER B 9 VAL B 11 0 SHEET 2 AA7 5 THR B 102 VAL B 104 1 O LYS B 103 N VAL B 11 SHEET 3 AA7 5 ASP B 85 TYR B 87 -1 N TYR B 86 O THR B 102 SHEET 4 AA7 5 TRP B 35 GLN B 38 -1 N GLN B 38 O ASP B 85 SHEET 5 AA7 5 LYS B 45 ILE B 48 -1 O LEU B 47 N TRP B 35 SHEET 1 AA8 3 VAL B 19 THR B 24 0 SHEET 2 AA8 3 SER B 70 ILE B 75 -1 O VAL B 71 N CYS B 23 SHEET 3 AA8 3 PHE B 62 SER B 67 -1 N SER B 67 O SER B 70 SHEET 1 AA9 2 GLN B 89 ASP B 92 0 SHEET 2 AA9 2 ALA B 95B PHE B 98 -1 O ALA B 95B N ASP B 92 SHEET 1 AB1 4 GLN A 3 SER A 7 0 SHEET 2 AB1 4 LEU A 18 SER A 25 -1 O VAL A 23 N VAL A 5 SHEET 3 AB1 4 THR A 77 MET A 82 -1 O MET A 82 N LEU A 18 SHEET 4 AB1 4 PHE A 67 ASP A 72 -1 N SER A 70 O TYR A 79 SHEET 1 AB2 6 GLY A 10 VAL A 12 0 SHEET 2 AB2 6 VAL A 107 VAL A 111 1 O THR A 110 N GLY A 10 SHEET 3 AB2 6 ALA A 88 VAL A 95 -1 N TYR A 90 O VAL A 107 SHEET 4 AB2 6 MET A 34 GLN A 39 -1 N VAL A 37 O TYR A 91 SHEET 5 AB2 6 LEU A 45 ILE A 51 -1 O GLU A 46 N ARG A 38 SHEET 6 AB2 6 LYS A 57 TYR A 59 -1 O TYR A 58 N VAL A 50 SHEET 1 AB3 4 GLY A 10 VAL A 12 0 SHEET 2 AB3 4 VAL A 107 VAL A 111 1 O THR A 110 N GLY A 10 SHEET 3 AB3 4 ALA A 88 VAL A 95 -1 N TYR A 90 O VAL A 107 SHEET 4 AB3 4 LEU A 100G TRP A 103 -1 O TYR A 102 N ARG A 94 SHEET 1 AB4 5 SER D 9 VAL D 11 0 SHEET 2 AB4 5 THR D 102 VAL D 104 1 O LYS D 103 N VAL D 11 SHEET 3 AB4 5 ALA D 84 TYR D 87 -1 N TYR D 86 O THR D 102 SHEET 4 AB4 5 TRP D 35 GLN D 38 -1 N GLN D 38 O ASP D 85 SHEET 5 AB4 5 LYS D 45 ILE D 48 -1 O LEU D 47 N TRP D 35 SHEET 1 AB5 3 VAL D 19 THR D 24 0 SHEET 2 AB5 3 SER D 70 ILE D 75 -1 O ILE D 75 N VAL D 19 SHEET 3 AB5 3 PHE D 62 SER D 67 -1 N SER D 67 O SER D 70 SHEET 1 AB6 2 GLN D 89 ASP D 92 0 SHEET 2 AB6 2 ALA D 95B PHE D 98 -1 O VAL D 97 N SER D 90 SHEET 1 AB7 4 GLN C 3 SER C 7 0 SHEET 2 AB7 4 LEU C 18 SER C 25 -1 O SER C 25 N GLN C 3 SHEET 3 AB7 4 THR C 77 MET C 82 -1 O MET C 82 N LEU C 18 SHEET 4 AB7 4 PHE C 67 ASP C 72 -1 N THR C 68 O GLN C 81 SHEET 1 AB8 6 GLY C 10 VAL C 12 0 SHEET 2 AB8 6 VAL C 107 VAL C 111 1 O THR C 110 N VAL C 12 SHEET 3 AB8 6 ALA C 88 VAL C 95 -1 N TYR C 90 O VAL C 107 SHEET 4 AB8 6 MET C 34 GLN C 39 -1 N VAL C 37 O TYR C 91 SHEET 5 AB8 6 LEU C 45 ILE C 51 -1 O GLU C 46 N ARG C 38 SHEET 6 AB8 6 LYS C 57 TYR C 59 -1 O TYR C 58 N VAL C 50 SHEET 1 AB9 4 GLY C 10 VAL C 12 0 SHEET 2 AB9 4 VAL C 107 VAL C 111 1 O THR C 110 N VAL C 12 SHEET 3 AB9 4 ALA C 88 VAL C 95 -1 N TYR C 90 O VAL C 107 SHEET 4 AB9 4 LEU C 100G TRP C 103 -1 O ASP C 101 N ARG C 94 SHEET 1 AC1 5 SER F 9 VAL F 11 0 SHEET 2 AC1 5 THR F 102 VAL F 104 1 O LYS F 103 N VAL F 11 SHEET 3 AC1 5 ASP F 85 ASP F 92 -1 N TYR F 86 O THR F 102 SHEET 4 AC1 5 HIS F 34 GLN F 38 -1 N GLN F 38 O ASP F 85 SHEET 5 AC1 5 LYS F 45 ILE F 48 -1 O LEU F 47 N TRP F 35 SHEET 1 AC2 4 SER F 9 VAL F 11 0 SHEET 2 AC2 4 THR F 102 VAL F 104 1 O LYS F 103 N VAL F 11 SHEET 3 AC2 4 ASP F 85 ASP F 92 -1 N TYR F 86 O THR F 102 SHEET 4 AC2 4 ALA F 95B PHE F 98 -1 O VAL F 97 N SER F 90 SHEET 1 AC3 3 VAL F 19 THR F 24 0 SHEET 2 AC3 3 SER F 70 ILE F 75 -1 O ILE F 75 N VAL F 19 SHEET 3 AC3 3 PHE F 62 SER F 67 -1 N SER F 67 O SER F 70 SHEET 1 AC4 4 GLN E 3 SER E 7 0 SHEET 2 AC4 4 LEU E 18 SER E 25 -1 O VAL E 23 N VAL E 5 SHEET 3 AC4 4 THR E 77 MET E 82 -1 O MET E 82 N LEU E 18 SHEET 4 AC4 4 PHE E 67 ASP E 72 -1 N THR E 68 O GLN E 81 SHEET 1 AC5 6 GLY E 10 VAL E 12 0 SHEET 2 AC5 6 VAL E 107 VAL E 111 1 O THR E 110 N VAL E 12 SHEET 3 AC5 6 ALA E 88 VAL E 95 -1 N TYR E 90 O VAL E 107 SHEET 4 AC5 6 MET E 34 GLN E 39 -1 N VAL E 37 O TYR E 91 SHEET 5 AC5 6 LEU E 45 ILE E 51 -1 O GLU E 46 N ARG E 38 SHEET 6 AC5 6 LYS E 57 TYR E 59 -1 O TYR E 58 N VAL E 50 SHEET 1 AC6 4 GLY E 10 VAL E 12 0 SHEET 2 AC6 4 VAL E 107 VAL E 111 1 O THR E 110 N VAL E 12 SHEET 3 AC6 4 ALA E 88 VAL E 95 -1 N TYR E 90 O VAL E 107 SHEET 4 AC6 4 LEU E 100G TRP E 103 -1 O TYR E 102 N ARG E 94 SHEET 1 AC7 5 SER N 9 VAL N 11 0 SHEET 2 AC7 5 THR N 102 VAL N 104 1 O LYS N 103 N VAL N 11 SHEET 3 AC7 5 ASP N 85 ASP N 92 -1 N TYR N 86 O THR N 102 SHEET 4 AC7 5 HIS N 34 GLN N 38 -1 N GLN N 38 O ASP N 85 SHEET 5 AC7 5 LYS N 45 ILE N 48 -1 O LEU N 47 N TRP N 35 SHEET 1 AC8 4 SER N 9 VAL N 11 0 SHEET 2 AC8 4 THR N 102 VAL N 104 1 O LYS N 103 N VAL N 11 SHEET 3 AC8 4 ASP N 85 ASP N 92 -1 N TYR N 86 O THR N 102 SHEET 4 AC8 4 ALA N 95B PHE N 98 -1 O VAL N 97 N SER N 90 SHEET 1 AC9 3 VAL N 19 THR N 24 0 SHEET 2 AC9 3 SER N 70 ILE N 75 -1 O ILE N 75 N VAL N 19 SHEET 3 AC9 3 PHE N 62 SER N 67 -1 N SER N 67 O SER N 70 SHEET 1 AD1 4 GLN M 3 SER M 7 0 SHEET 2 AD1 4 LEU M 18 SER M 25 -1 O VAL M 23 N VAL M 5 SHEET 3 AD1 4 THR M 77 MET M 82 -1 O MET M 82 N LEU M 18 SHEET 4 AD1 4 PHE M 67 ASP M 72 -1 N THR M 68 O GLN M 81 SHEET 1 AD2 6 GLY M 10 VAL M 12 0 SHEET 2 AD2 6 VAL M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AD2 6 ALA M 88 VAL M 95 -1 N TYR M 90 O VAL M 107 SHEET 4 AD2 6 MET M 34 GLN M 39 -1 N VAL M 37 O TYR M 91 SHEET 5 AD2 6 LEU M 45 ILE M 51 -1 O GLU M 46 N ARG M 38 SHEET 6 AD2 6 LYS M 57 TYR M 59 -1 O TYR M 58 N VAL M 50 SHEET 1 AD3 4 GLY M 10 VAL M 12 0 SHEET 2 AD3 4 VAL M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AD3 4 ALA M 88 VAL M 95 -1 N TYR M 90 O VAL M 107 SHEET 4 AD3 4 LEU M 100G TRP M 103 -1 O TYR M 102 N ARG M 94 SHEET 1 AD4 5 SER P 9 VAL P 11 0 SHEET 2 AD4 5 THR P 102 VAL P 104 1 O LYS P 103 N VAL P 11 SHEET 3 AD4 5 ALA P 84 TYR P 87 -1 N TYR P 86 O THR P 102 SHEET 4 AD4 5 TRP P 35 GLN P 38 -1 N GLN P 38 O ASP P 85 SHEET 5 AD4 5 LYS P 45 ILE P 48 -1 O LEU P 47 N TRP P 35 SHEET 1 AD5 3 VAL P 19 THR P 24 0 SHEET 2 AD5 3 SER P 70 ILE P 75 -1 O ILE P 75 N VAL P 19 SHEET 3 AD5 3 PHE P 62 SER P 67 -1 N SER P 67 O SER P 70 SHEET 1 AD6 2 GLN P 89 ASP P 92 0 SHEET 2 AD6 2 ALA P 95B PHE P 98 -1 O VAL P 97 N SER P 90 SHEET 1 AD7 4 GLN O 3 SER O 7 0 SHEET 2 AD7 4 LEU O 18 SER O 25 -1 O SER O 25 N GLN O 3 SHEET 3 AD7 4 THR O 77 MET O 82 -1 O MET O 82 N LEU O 18 SHEET 4 AD7 4 PHE O 67 ASP O 72 -1 N THR O 68 O GLN O 81 SHEET 1 AD8 6 GLY O 10 VAL O 12 0 SHEET 2 AD8 6 VAL O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AD8 6 ALA O 88 VAL O 95 -1 N TYR O 90 O VAL O 107 SHEET 4 AD8 6 MET O 34 GLN O 39 -1 N VAL O 37 O TYR O 91 SHEET 5 AD8 6 LEU O 45 ILE O 51 -1 O GLU O 46 N ARG O 38 SHEET 6 AD8 6 LYS O 57 TYR O 59 -1 O TYR O 58 N VAL O 50 SHEET 1 AD9 4 GLY O 10 VAL O 12 0 SHEET 2 AD9 4 VAL O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AD9 4 ALA O 88 VAL O 95 -1 N TYR O 90 O VAL O 107 SHEET 4 AD9 4 LEU O 100G TRP O 103 -1 O ASP O 101 N ARG O 94 SHEET 1 AE1 5 SER R 9 VAL R 11 0 SHEET 2 AE1 5 THR R 102 VAL R 104 1 O LYS R 103 N VAL R 11 SHEET 3 AE1 5 ASP R 85 TYR R 87 -1 N TYR R 86 O THR R 102 SHEET 4 AE1 5 TRP R 35 GLN R 38 -1 N GLN R 38 O ASP R 85 SHEET 5 AE1 5 LYS R 45 ILE R 48 -1 O ILE R 48 N TRP R 35 SHEET 1 AE2 3 VAL R 19 THR R 24 0 SHEET 2 AE2 3 SER R 70 ILE R 75 -1 O ILE R 75 N VAL R 19 SHEET 3 AE2 3 PHE R 62 SER R 67 -1 N SER R 67 O SER R 70 SHEET 1 AE3 2 GLN R 89 ASP R 92 0 SHEET 2 AE3 2 ALA R 95B PHE R 98 -1 O VAL R 97 N SER R 90 SHEET 1 AE4 4 GLN Q 3 SER Q 7 0 SHEET 2 AE4 4 LEU Q 18 SER Q 25 -1 O SER Q 25 N GLN Q 3 SHEET 3 AE4 4 THR Q 77 MET Q 82 -1 O MET Q 82 N LEU Q 18 SHEET 4 AE4 4 PHE Q 67 ASP Q 72 -1 N THR Q 68 O GLN Q 81 SHEET 1 AE5 6 GLY Q 10 VAL Q 12 0 SHEET 2 AE5 6 VAL Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AE5 6 ALA Q 88 VAL Q 95 -1 N TYR Q 90 O VAL Q 107 SHEET 4 AE5 6 MET Q 34 GLN Q 39 -1 N VAL Q 37 O TYR Q 91 SHEET 5 AE5 6 LEU Q 45 ILE Q 51 -1 O GLU Q 46 N ARG Q 38 SHEET 6 AE5 6 LYS Q 57 TYR Q 59 -1 O TYR Q 58 N VAL Q 50 SHEET 1 AE6 4 GLY Q 10 VAL Q 12 0 SHEET 2 AE6 4 VAL Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AE6 4 ALA Q 88 VAL Q 95 -1 N TYR Q 90 O VAL Q 107 SHEET 4 AE6 4 LEU Q 100G TRP Q 103 -1 O ASP Q 101 N ARG Q 94 SHEET 1 AE7 5 SER T 9 VAL T 11 0 SHEET 2 AE7 5 THR T 102 VAL T 104 1 O LYS T 103 N VAL T 11 SHEET 3 AE7 5 ASP T 85 TYR T 87 -1 N TYR T 86 O THR T 102 SHEET 4 AE7 5 TRP T 35 GLN T 38 -1 N GLN T 38 O ASP T 85 SHEET 5 AE7 5 LYS T 45 ILE T 48 -1 O LEU T 47 N TRP T 35 SHEET 1 AE8 3 VAL T 19 THR T 24 0 SHEET 2 AE8 3 SER T 70 ILE T 75 -1 O VAL T 71 N CYS T 23 SHEET 3 AE8 3 PHE T 62 SER T 67 -1 N SER T 67 O SER T 70 SHEET 1 AE9 2 GLN T 89 ASP T 92 0 SHEET 2 AE9 2 ALA T 95B PHE T 98 -1 O ALA T 95B N ASP T 92 SHEET 1 AF1 4 GLN S 3 SER S 7 0 SHEET 2 AF1 4 LEU S 18 SER S 25 -1 O VAL S 23 N VAL S 5 SHEET 3 AF1 4 THR S 77 MET S 82 -1 O MET S 82 N LEU S 18 SHEET 4 AF1 4 PHE S 67 ASP S 72 -1 N SER S 70 O TYR S 79 SHEET 1 AF2 6 GLY S 10 VAL S 12 0 SHEET 2 AF2 6 VAL S 107 VAL S 111 1 O THR S 110 N GLY S 10 SHEET 3 AF2 6 ALA S 88 VAL S 95 -1 N TYR S 90 O VAL S 107 SHEET 4 AF2 6 MET S 34 GLN S 39 -1 N VAL S 37 O TYR S 91 SHEET 5 AF2 6 LEU S 45 ILE S 51 -1 O GLU S 46 N ARG S 38 SHEET 6 AF2 6 LYS S 57 TYR S 59 -1 O TYR S 58 N VAL S 50 SHEET 1 AF3 4 GLY S 10 VAL S 12 0 SHEET 2 AF3 4 VAL S 107 VAL S 111 1 O THR S 110 N GLY S 10 SHEET 3 AF3 4 ALA S 88 VAL S 95 -1 N TYR S 90 O VAL S 107 SHEET 4 AF3 4 LEU S 100G TRP S 103 -1 O TYR S 102 N ARG S 94 SSBOND 1 CYS L 23 CYS L 88 1555 1555 2.02 SSBOND 2 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 3 CYS B 23 CYS B 88 1555 1555 2.03 SSBOND 4 CYS A 22 CYS A 92 1555 1555 2.03 SSBOND 5 CYS D 23 CYS D 88 1555 1555 2.02 SSBOND 6 CYS C 22 CYS C 92 1555 1555 2.03 SSBOND 7 CYS F 23 CYS F 88 1555 1555 2.02 SSBOND 8 CYS E 22 CYS E 92 1555 1555 2.04 SSBOND 9 CYS N 23 CYS N 88 1555 1555 2.02 SSBOND 10 CYS M 22 CYS M 92 1555 1555 2.04 SSBOND 11 CYS P 23 CYS P 88 1555 1555 2.02 SSBOND 12 CYS O 22 CYS O 92 1555 1555 2.03 SSBOND 13 CYS R 23 CYS R 88 1555 1555 2.02 SSBOND 14 CYS Q 22 CYS Q 92 1555 1555 2.03 SSBOND 15 CYS T 23 CYS T 88 1555 1555 2.03 SSBOND 16 CYS S 22 CYS S 92 1555 1555 2.03 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000