data_8EN6
# 
_entry.id   8EN6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.367 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8EN6         pdb_00008en6 10.2210/pdb8en6/pdb 
WWPDB D_1000267284 ?            ?                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8EN6 
_pdbx_database_status.recvd_initial_deposition_date   2022-09-28 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kher, G.'        1 ? 
'Sabin, C.'       2 ? 
'Pancera, M.'     3 ? 
'Koromyslova, A.' 4 ? 
'Hansman, G.'     5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of GII.17 norovirus in complex with Nanobody 76' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kher, G.'        1 ? 
primary 'Sabin, C.'       2 ? 
primary 'Pancera, M.'     3 ? 
primary 'Koromyslova, A.' 4 ? 
primary 'Hansman, G.'     5 ? 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8EN6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.412 
_cell.length_a_esd                 ? 
_cell.length_b                     119.706 
_cell.length_b_esd                 ? 
_cell.length_c                     127.816 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8EN6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'GII.17 P domain'    34074.988 2   ? ? ? ? 
2 polymer     man 'Nanobody 76'        13212.732 2   ? ? ? ? 
3 non-polymer syn GLYCEROL             92.094    5   ? ? ? ? 
4 non-polymer syn 'ISOPROPYL ALCOHOL'  60.095    2   ? ? ? ? 
5 non-polymer syn 1,2-ETHANEDIOL       62.068    7   ? ? ? ? 
6 non-polymer syn 'DIMETHYL SULFOXIDE' 78.133    1   ? ? ? ? 
7 water       nat water                18.015    872 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;TKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTTQLSPVNICTFRGDVTHITGSRNYTMNL
ASQNWNDYDPTEEIPAPLGTPDFVGKIQGVLTQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDRDFEANQNTKF
TPVGVIQDGGTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQYFYQ
EAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLVIPPNGYFRFDSWVNQFYTLAPM
;
;TKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTTQLSPVNICTFRGDVTHITGSRNYTMNL
ASQNWNDYDPTEEIPAPLGTPDFVGKIQGVLTQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDRDFEANQNTKF
TPVGVIQDGGTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQYFYQ
EAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLVIPPNGYFRFDSWVNQFYTLAPM
;
A,B ? 
2 'polypeptide(L)' no no 
;QVQLQESGGGLVQAGGSLRLSCAASGTIFSIDAFGWYRQAPGKQREWVAGITSGSSTIYADFVKGRFTISRDNAKNTVFL
QMNSLKPEDTAVYYCNRAKPPTYYSLEPWGKGTQVTVSSHH
;
;QVQLQESGGGLVQAGGSLRLSCAASGTIFSIDAFGWYRQAPGKQREWVAGITSGSSTIYADFVKGRFTISRDNAKNTVFL
QMNSLKPEDTAVYYCNRAKPPTYYSLEPWGKGTQVTVSSHH
;
C,D ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   THR n 
1 2   LYS n 
1 3   PRO n 
1 4   PHE n 
1 5   SER n 
1 6   VAL n 
1 7   PRO n 
1 8   VAL n 
1 9   LEU n 
1 10  THR n 
1 11  VAL n 
1 12  GLU n 
1 13  GLU n 
1 14  MET n 
1 15  THR n 
1 16  ASN n 
1 17  SER n 
1 18  ARG n 
1 19  PHE n 
1 20  PRO n 
1 21  ILE n 
1 22  PRO n 
1 23  LEU n 
1 24  GLU n 
1 25  LYS n 
1 26  LEU n 
1 27  PHE n 
1 28  THR n 
1 29  GLY n 
1 30  PRO n 
1 31  SER n 
1 32  SER n 
1 33  ALA n 
1 34  PHE n 
1 35  VAL n 
1 36  VAL n 
1 37  GLN n 
1 38  PRO n 
1 39  GLN n 
1 40  ASN n 
1 41  GLY n 
1 42  ARG n 
1 43  CYS n 
1 44  THR n 
1 45  THR n 
1 46  ASP n 
1 47  GLY n 
1 48  VAL n 
1 49  LEU n 
1 50  LEU n 
1 51  GLY n 
1 52  THR n 
1 53  THR n 
1 54  GLN n 
1 55  LEU n 
1 56  SER n 
1 57  PRO n 
1 58  VAL n 
1 59  ASN n 
1 60  ILE n 
1 61  CYS n 
1 62  THR n 
1 63  PHE n 
1 64  ARG n 
1 65  GLY n 
1 66  ASP n 
1 67  VAL n 
1 68  THR n 
1 69  HIS n 
1 70  ILE n 
1 71  THR n 
1 72  GLY n 
1 73  SER n 
1 74  ARG n 
1 75  ASN n 
1 76  TYR n 
1 77  THR n 
1 78  MET n 
1 79  ASN n 
1 80  LEU n 
1 81  ALA n 
1 82  SER n 
1 83  GLN n 
1 84  ASN n 
1 85  TRP n 
1 86  ASN n 
1 87  ASP n 
1 88  TYR n 
1 89  ASP n 
1 90  PRO n 
1 91  THR n 
1 92  GLU n 
1 93  GLU n 
1 94  ILE n 
1 95  PRO n 
1 96  ALA n 
1 97  PRO n 
1 98  LEU n 
1 99  GLY n 
1 100 THR n 
1 101 PRO n 
1 102 ASP n 
1 103 PHE n 
1 104 VAL n 
1 105 GLY n 
1 106 LYS n 
1 107 ILE n 
1 108 GLN n 
1 109 GLY n 
1 110 VAL n 
1 111 LEU n 
1 112 THR n 
1 113 GLN n 
1 114 THR n 
1 115 THR n 
1 116 ARG n 
1 117 THR n 
1 118 ASP n 
1 119 GLY n 
1 120 SER n 
1 121 THR n 
1 122 ARG n 
1 123 GLY n 
1 124 HIS n 
1 125 LYS n 
1 126 ALA n 
1 127 THR n 
1 128 VAL n 
1 129 TYR n 
1 130 THR n 
1 131 GLY n 
1 132 SER n 
1 133 ALA n 
1 134 ASP n 
1 135 PHE n 
1 136 ALA n 
1 137 PRO n 
1 138 LYS n 
1 139 LEU n 
1 140 GLY n 
1 141 ARG n 
1 142 VAL n 
1 143 GLN n 
1 144 PHE n 
1 145 GLU n 
1 146 THR n 
1 147 ASP n 
1 148 THR n 
1 149 ASP n 
1 150 ARG n 
1 151 ASP n 
1 152 PHE n 
1 153 GLU n 
1 154 ALA n 
1 155 ASN n 
1 156 GLN n 
1 157 ASN n 
1 158 THR n 
1 159 LYS n 
1 160 PHE n 
1 161 THR n 
1 162 PRO n 
1 163 VAL n 
1 164 GLY n 
1 165 VAL n 
1 166 ILE n 
1 167 GLN n 
1 168 ASP n 
1 169 GLY n 
1 170 GLY n 
1 171 THR n 
1 172 THR n 
1 173 HIS n 
1 174 ARG n 
1 175 ASN n 
1 176 GLU n 
1 177 PRO n 
1 178 GLN n 
1 179 GLN n 
1 180 TRP n 
1 181 VAL n 
1 182 LEU n 
1 183 PRO n 
1 184 SER n 
1 185 TYR n 
1 186 SER n 
1 187 GLY n 
1 188 ARG n 
1 189 ASN n 
1 190 THR n 
1 191 HIS n 
1 192 ASN n 
1 193 VAL n 
1 194 HIS n 
1 195 LEU n 
1 196 ALA n 
1 197 PRO n 
1 198 ALA n 
1 199 VAL n 
1 200 ALA n 
1 201 PRO n 
1 202 THR n 
1 203 PHE n 
1 204 PRO n 
1 205 GLY n 
1 206 GLU n 
1 207 GLN n 
1 208 LEU n 
1 209 LEU n 
1 210 PHE n 
1 211 PHE n 
1 212 ARG n 
1 213 SER n 
1 214 THR n 
1 215 MET n 
1 216 PRO n 
1 217 GLY n 
1 218 CYS n 
1 219 SER n 
1 220 GLY n 
1 221 TYR n 
1 222 PRO n 
1 223 ASN n 
1 224 MET n 
1 225 ASP n 
1 226 LEU n 
1 227 ASP n 
1 228 CYS n 
1 229 LEU n 
1 230 LEU n 
1 231 PRO n 
1 232 GLN n 
1 233 GLU n 
1 234 TRP n 
1 235 VAL n 
1 236 GLN n 
1 237 TYR n 
1 238 PHE n 
1 239 TYR n 
1 240 GLN n 
1 241 GLU n 
1 242 ALA n 
1 243 ALA n 
1 244 PRO n 
1 245 ALA n 
1 246 GLN n 
1 247 SER n 
1 248 ASP n 
1 249 VAL n 
1 250 ALA n 
1 251 LEU n 
1 252 LEU n 
1 253 ARG n 
1 254 PHE n 
1 255 VAL n 
1 256 ASN n 
1 257 PRO n 
1 258 ASP n 
1 259 THR n 
1 260 GLY n 
1 261 ARG n 
1 262 VAL n 
1 263 LEU n 
1 264 PHE n 
1 265 GLU n 
1 266 CYS n 
1 267 LYS n 
1 268 LEU n 
1 269 HIS n 
1 270 LYS n 
1 271 SER n 
1 272 GLY n 
1 273 TYR n 
1 274 VAL n 
1 275 THR n 
1 276 VAL n 
1 277 ALA n 
1 278 HIS n 
1 279 THR n 
1 280 GLY n 
1 281 GLN n 
1 282 HIS n 
1 283 ASP n 
1 284 LEU n 
1 285 VAL n 
1 286 ILE n 
1 287 PRO n 
1 288 PRO n 
1 289 ASN n 
1 290 GLY n 
1 291 TYR n 
1 292 PHE n 
1 293 ARG n 
1 294 PHE n 
1 295 ASP n 
1 296 SER n 
1 297 TRP n 
1 298 VAL n 
1 299 ASN n 
1 300 GLN n 
1 301 PHE n 
1 302 TYR n 
1 303 THR n 
1 304 LEU n 
1 305 ALA n 
1 306 PRO n 
1 307 MET n 
2 1   GLN n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   GLN n 
2 6   GLU n 
2 7   SER n 
2 8   GLY n 
2 9   GLY n 
2 10  GLY n 
2 11  LEU n 
2 12  VAL n 
2 13  GLN n 
2 14  ALA n 
2 15  GLY n 
2 16  GLY n 
2 17  SER n 
2 18  LEU n 
2 19  ARG n 
2 20  LEU n 
2 21  SER n 
2 22  CYS n 
2 23  ALA n 
2 24  ALA n 
2 25  SER n 
2 26  GLY n 
2 27  THR n 
2 28  ILE n 
2 29  PHE n 
2 30  SER n 
2 31  ILE n 
2 32  ASP n 
2 33  ALA n 
2 34  PHE n 
2 35  GLY n 
2 36  TRP n 
2 37  TYR n 
2 38  ARG n 
2 39  GLN n 
2 40  ALA n 
2 41  PRO n 
2 42  GLY n 
2 43  LYS n 
2 44  GLN n 
2 45  ARG n 
2 46  GLU n 
2 47  TRP n 
2 48  VAL n 
2 49  ALA n 
2 50  GLY n 
2 51  ILE n 
2 52  THR n 
2 53  SER n 
2 54  GLY n 
2 55  SER n 
2 56  SER n 
2 57  THR n 
2 58  ILE n 
2 59  TYR n 
2 60  ALA n 
2 61  ASP n 
2 62  PHE n 
2 63  VAL n 
2 64  LYS n 
2 65  GLY n 
2 66  ARG n 
2 67  PHE n 
2 68  THR n 
2 69  ILE n 
2 70  SER n 
2 71  ARG n 
2 72  ASP n 
2 73  ASN n 
2 74  ALA n 
2 75  LYS n 
2 76  ASN n 
2 77  THR n 
2 78  VAL n 
2 79  PHE n 
2 80  LEU n 
2 81  GLN n 
2 82  MET n 
2 83  ASN n 
2 84  SER n 
2 85  LEU n 
2 86  LYS n 
2 87  PRO n 
2 88  GLU n 
2 89  ASP n 
2 90  THR n 
2 91  ALA n 
2 92  VAL n 
2 93  TYR n 
2 94  TYR n 
2 95  CYS n 
2 96  ASN n 
2 97  ARG n 
2 98  ALA n 
2 99  LYS n 
2 100 PRO n 
2 101 PRO n 
2 102 THR n 
2 103 TYR n 
2 104 TYR n 
2 105 SER n 
2 106 LEU n 
2 107 GLU n 
2 108 PRO n 
2 109 TRP n 
2 110 GLY n 
2 111 LYS n 
2 112 GLY n 
2 113 THR n 
2 114 GLN n 
2 115 VAL n 
2 116 THR n 
2 117 VAL n 
2 118 SER n 
2 119 SER n 
2 120 HIS n 
2 121 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 307 ? ? ? ? ? ? ? ? ? Norovirus       142786 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 121 ? ? ? ? ? ? ? ? ? 'Vicugna pacos' 30538  ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP K4LM89_9CALI K4LM89 ? 1 
;TKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTTQLSPVNICTFRGDVTHITGSRNYTMNL
ASQNWNDYDPTEEIPAPLGTPDFVGKIQGVLTQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDRDFEANQNTKF
TPVGVIQDGGTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQYFYQ
EAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLVIPPNGYFRFDSWVNQFYTLAPM
;
224 
2 PDB 8EN6         8EN6   ? 2 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8EN6 A 1 ? 307 ? K4LM89 224 ? 530 ? 224 530 
2 2 8EN6 C 1 ? 121 ? 8EN6   1   ? 121 ? 1   121 
3 1 8EN6 B 1 ? 307 ? K4LM89 224 ? 530 ? 224 530 
4 2 8EN6 D 1 ? 121 ? 8EN6   1   ? 121 ? 1   121 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE              ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE             ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE           ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE             ?                               'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE' ?                               'C2 H6 O S'      78.133  
EDO non-polymer         . 1,2-ETHANEDIOL       'ETHYLENE GLYCOL'               'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE            ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE              ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL             'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE            ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ?                               'C6 H13 N O2'    131.173 
IPA non-polymer         . 'ISOPROPYL ALCOHOL'  2-PROPANOL                      'C3 H8 O'        60.095  
LEU 'L-peptide linking' y LEUCINE              ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE               ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE           ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE              ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE               ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE            ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN           ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE             ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE               ?                               'C5 H11 N O2'    117.146 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8EN6 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.01 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          59.19 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp            291.15 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '17% [w/v] PEG4000, 0.0095 M HEPES [pH 7.5], 8.5% [v/v] isopropanol, and 15% glycerol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M-F' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-10-19 
_diffrn_detector.pdbx_frequency               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL14-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL14-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          11.670 
_reflns.entry_id                                       8EN6 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.530 
_reflns.d_resolution_low                               87.370 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     171712 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.800 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.400 
_reflns.pdbx_Rmerge_I_obs                              0.083 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.300 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           1404 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.094 
_reflns.pdbx_Rpim_I_all                                0.044 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       754982 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
_reflns.pdbx_CC_split_method                           ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_all 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
1.530 1.560  ? ? 33211 ? ? ? 8330 98.400 ? ? ? ? 0.751 ? ? ? ? ? ? ? ? 4.000 ? ? ? 1.500  0.864 0.419 ? 1 1 0.639 ? ? ? ? ? ? ? ? 
? ? 
8.380 87.370 ? ? 5191  ? ? ? 1168 98.400 ? ? ? ? 0.028 ? ? ? ? ? ? ? ? 4.400 ? ? ? 27.600 0.033 0.015 ? 2 1 0.997 ? ? ? ? ? ? ? ? 
? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                98.540 
_refine.B_iso_mean                               17.6947 
_refine.B_iso_min                                4.090 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8EN6 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.6000 
_refine.ls_d_res_low                             64.3100 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     150255 
_refine.ls_number_reflns_R_free                  7305 
_refine.ls_number_reflns_R_work                  142950 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.7100 
_refine.ls_percent_reflns_R_free                 4.8600 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1740 
_refine.ls_R_factor_R_free                       0.1944 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1730 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.340 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      4oos 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.3100 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1400 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         final 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.6000 
_refine_hist.d_res_low                        64.3100 
_refine_hist.number_atoms_solvent             872 
_refine_hist.number_atoms_total               7628 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       855 
_refine_hist.pdbx_B_iso_mean_ligand           27.14 
_refine_hist.pdbx_B_iso_mean_solvent          25.19 
_refine_hist.pdbx_number_atoms_protein        6656 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         100 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
'X-RAY DIFFRACTION' 1.6000 1.6200  5032 . 227 4805 100.0000 . . . 0.2465 0.0000 0.2315 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.6200 1.6400  4928 . 240 4688 100.0000 . . . 0.2683 0.0000 0.2225 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.6400 1.6600  4969 . 232 4737 100.0000 . . . 0.2518 0.0000 0.2173 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.6600 1.6800  4959 . 213 4746 100.0000 . . . 0.2293 0.0000 0.2042 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.6800 1.7000  4992 . 239 4753 100.0000 . . . 0.2290 0.0000 0.2025 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.7000 1.7200  4920 . 234 4686 100.0000 . . . 0.2284 0.0000 0.1968 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.7200 1.7500  4959 . 226 4733 100.0000 . . . 0.2182 0.0000 0.1943 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.7500 1.7700  4981 . 225 4756 99.0000  . . . 0.2102 0.0000 0.1907 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.7700 1.8000  4923 . 241 4682 99.0000  . . . 0.2053 0.0000 0.1917 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.8000 1.8300  4926 . 238 4688 99.0000  . . . 0.2319 0.0000 0.1892 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.8300 1.8600  4994 . 240 4754 100.0000 . . . 0.2033 0.0000 0.1908 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.8600 1.9000  4967 . 272 4695 100.0000 . . . 0.2321 0.0000 0.1877 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.9000 1.9300  4980 . 225 4755 100.0000 . . . 0.2147 0.0000 0.1815 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.9300 1.9700  4989 . 254 4735 100.0000 . . . 0.2064 0.0000 0.1685 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 1.9700 2.0200  4995 . 260 4735 100.0000 . . . 0.1714 0.0000 0.1623 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.0200 2.0600  4971 . 243 4728 100.0000 . . . 0.1932 0.0000 0.1621 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.0600 2.1100  4995 . 256 4739 100.0000 . . . 0.1823 0.0000 0.1622 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.1100 2.1700  5014 . 270 4744 100.0000 . . . 0.1779 0.0000 0.1677 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.1700 2.2400  5001 . 253 4748 100.0000 . . . 0.1887 0.0000 0.1648 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.2400 2.3100  4998 . 274 4724 100.0000 . . . 0.2058 0.0000 0.1709 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.3100 2.3900  5019 . 239 4780 100.0000 . . . 0.2132 0.0000 0.1754 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.3900 2.4900  5015 . 258 4757 100.0000 . . . 0.2034 0.0000 0.1750 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.4900 2.6000  5014 . 252 4762 100.0000 . . . 0.2027 0.0000 0.1783 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.6000 2.7400  5041 . 275 4766 100.0000 . . . 0.2069 0.0000 0.1752 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.7400 2.9100  5027 . 227 4800 100.0000 . . . 0.1937 0.0000 0.1768 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 2.9100 3.1300  5086 . 234 4852 100.0000 . . . 0.1797 0.0000 0.1716 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 3.1300 3.4500  5036 . 249 4787 99.0000  . . . 0.1876 0.0000 0.1682 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 3.4500 3.9500  5101 . 221 4880 100.0000 . . . 0.1625 0.0000 0.1597 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 3.9500 4.9700  5163 . 273 4890 100.0000 . . . 0.1571 0.0000 0.1395 . . . . . . . 30 . . . 
'X-RAY DIFFRACTION' 4.9700 64.3100 5260 . 215 5045 98.0000  . . . 0.1779 0.0000 0.1686 . . . . . . . 30 . . . 
# 
_struct.entry_id                     8EN6 
_struct.title                        'Structure of GII.17 norovirus in complex with Nanobody 76' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8EN6 
_struct_keywords.text            'norovirus, Nanobody, inhibitor, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 4 ? 
H N N 3 ? 
I N N 5 ? 
J N N 5 ? 
K N N 5 ? 
L N N 3 ? 
M N N 5 ? 
N N N 6 ? 
O N N 5 ? 
P N N 5 ? 
Q N N 5 ? 
R N N 3 ? 
S N N 4 ? 
T N N 7 ? 
U N N 7 ? 
V N N 7 ? 
W N N 7 ? 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 10  ? MET A 14  ? THR A 233 MET A 237 5 ? 5  
HELX_P HELX_P2  AA2 SER A 56  ? ILE A 60  ? SER A 279 ILE A 283 5 ? 5  
HELX_P HELX_P3  AA3 ALA A 136 ? LEU A 139 ? ALA A 359 LEU A 362 5 ? 4  
HELX_P HELX_P4  AA4 PRO A 231 ? ALA A 242 ? PRO A 454 ALA A 465 1 ? 12 
HELX_P HELX_P5  AA5 ILE B 28  ? ASP B 32  ? ILE C 28  ASP C 32  5 ? 5  
HELX_P HELX_P6  AA6 ASN B 73  ? LYS B 75  ? ASN C 73  LYS C 75  5 ? 3  
HELX_P HELX_P7  AA7 LYS B 86  ? THR B 90  ? LYS C 86  THR C 90  5 ? 5  
HELX_P HELX_P8  AA8 THR C 10  ? MET C 14  ? THR B 233 MET B 237 5 ? 5  
HELX_P HELX_P9  AA9 SER C 56  ? ILE C 60  ? SER B 279 ILE B 283 5 ? 5  
HELX_P HELX_P10 AB1 ALA C 136 ? LEU C 139 ? ALA B 359 LEU B 362 5 ? 4  
HELX_P HELX_P11 AB2 PRO C 231 ? ALA C 242 ? PRO B 454 ALA B 465 1 ? 12 
HELX_P HELX_P12 AB3 ILE D 28  ? ASP D 32  ? ILE D 28  ASP D 32  5 ? 5  
HELX_P HELX_P13 AB4 ASP D 61  ? LYS D 64  ? ASP D 61  LYS D 64  5 ? 4  
HELX_P HELX_P14 AB5 ASN D 73  ? LYS D 75  ? ASN D 73  LYS D 75  5 ? 3  
HELX_P HELX_P15 AB6 LYS D 86  ? THR D 90  ? LYS D 86  THR D 90  5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? B CYS 22 SG ? ? ? 1_555 B CYS 95 SG ? ? C CYS 22 C CYS 95 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
disulf2 disulf ? ? D CYS 22 SG ? ? ? 1_555 D CYS 95 SG ? ? D CYS 22 D CYS 95 1_555 ? ? ? ? ? ? ? 2.014 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 176 A . ? GLU 399 A PRO 177 A ? PRO 400 A 1 -9.30 
2 PRO 100 B . ? PRO 100 C PRO 101 B ? PRO 101 C 1 5.27  
3 GLU 176 C . ? GLU 399 B PRO 177 C ? PRO 400 B 1 -8.18 
4 PRO 100 D . ? PRO 100 D PRO 101 D ? PRO 101 D 1 5.54  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8  ? 
AA2 ? 14 ? 
AA3 ? 4  ? 
AA4 ? 7  ? 
AA5 ? 8  ? 
AA6 ? 4  ? 
AA7 ? 7  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 1  7  ? anti-parallel 
AA1 2  3  ? anti-parallel 
AA1 2  6  ? anti-parallel 
AA1 4  5  ? anti-parallel 
AA1 4  8  ? anti-parallel 
AA1 5  6  ? anti-parallel 
AA2 1  2  ? anti-parallel 
AA2 1  6  ? anti-parallel 
AA2 2  5  ? anti-parallel 
AA2 3  4  ? anti-parallel 
AA2 3  6  ? anti-parallel 
AA2 4  5  ? anti-parallel 
AA2 4  14 ? anti-parallel 
AA2 6  7  ? parallel      
AA2 7  11 ? anti-parallel 
AA2 8  9  ? anti-parallel 
AA2 8  13 ? anti-parallel 
AA2 9  12 ? anti-parallel 
AA2 10 11 ? anti-parallel 
AA2 10 13 ? anti-parallel 
AA2 11 12 ? anti-parallel 
AA2 13 14 ? parallel      
AA3 1  2  ? anti-parallel 
AA3 2  3  ? anti-parallel 
AA3 3  4  ? anti-parallel 
AA4 1  7  ? parallel      
AA4 2  3  ? anti-parallel 
AA4 2  5  ? anti-parallel 
AA4 3  4  ? anti-parallel 
AA4 5  6  ? anti-parallel 
AA4 5  7  ? anti-parallel 
AA5 1  2  ? anti-parallel 
AA5 1  7  ? anti-parallel 
AA5 2  3  ? anti-parallel 
AA5 2  6  ? anti-parallel 
AA5 4  5  ? anti-parallel 
AA5 4  8  ? anti-parallel 
AA5 5  6  ? anti-parallel 
AA6 1  2  ? anti-parallel 
AA6 2  3  ? anti-parallel 
AA6 3  4  ? anti-parallel 
AA7 1  7  ? parallel      
AA7 2  3  ? anti-parallel 
AA7 2  5  ? anti-parallel 
AA7 3  4  ? anti-parallel 
AA7 5  6  ? anti-parallel 
AA7 5  7  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  LYS A 25  ? THR A 28  ? LYS A 248 THR A 251 
AA1 2  GLU A 206 ? THR A 214 ? GLU A 429 THR A 437 
AA1 3  ASP A 225 ? CYS A 228 ? ASP A 448 CYS A 451 
AA1 4  VAL A 249 ? VAL A 255 ? VAL A 472 VAL A 478 
AA1 5  VAL A 262 ? HIS A 269 ? VAL A 485 HIS A 492 
AA1 6  TYR A 273 ? ALA A 277 ? TYR A 496 ALA A 500 
AA1 7  HIS A 282 ? ASP A 283 ? HIS A 505 ASP A 506 
AA1 8  TYR A 291 ? VAL A 298 ? TYR A 514 VAL A 521 
AA2 1  PHE A 63  ? HIS A 69  ? PHE A 286 HIS A 292 
AA2 2  ASN A 75  ? LEU A 80  ? ASN A 298 LEU A 303 
AA2 3  LYS A 106 ? THR A 114 ? LYS A 329 THR A 337 
AA2 4  THR A 121 ? TYR A 129 ? THR A 344 TYR A 352 
AA2 5  ARG A 141 ? THR A 146 ? ARG A 364 THR A 369 
AA2 6  THR A 158 ? ILE A 166 ? THR A 381 ILE A 389 
AA2 7  GLY A 217 ? GLY A 220 ? GLY A 440 GLY A 443 
AA2 8  PHE C 63  ? THR C 68  ? PHE B 286 THR B 291 
AA2 9  ASN C 75  ? LEU C 80  ? ASN B 298 LEU B 303 
AA2 10 LYS C 106 ? THR C 114 ? LYS B 329 THR B 337 
AA2 11 THR C 121 ? TYR C 129 ? THR B 344 TYR B 352 
AA2 12 ARG C 141 ? THR C 146 ? ARG B 364 THR B 369 
AA2 13 THR C 158 ? ILE C 166 ? THR B 381 ILE B 389 
AA2 14 GLY C 217 ? GLY C 220 ? GLY B 440 GLY B 443 
AA3 1  GLN B 3   ? SER B 7   ? GLN C 3   SER C 7   
AA3 2  LEU B 18  ? SER B 25  ? LEU C 18  SER C 25  
AA3 3  THR B 77  ? MET B 82  ? THR C 77  MET C 82  
AA3 4  PHE B 67  ? ASP B 72  ? PHE C 67  ASP C 72  
AA4 1  GLY B 10  ? GLN B 13  ? GLY C 10  GLN C 13  
AA4 2  ALA B 33  ? GLN B 39  ? ALA C 33  GLN C 39  
AA4 3  GLU B 46  ? ILE B 51  ? GLU C 46  ILE C 51  
AA4 4  THR B 57  ? TYR B 59  ? THR C 57  TYR C 59  
AA4 5  ALA B 91  ? LYS B 99  ? ALA C 91  LYS C 99  
AA4 6  TYR B 104 ? SER B 105 ? TYR C 104 SER C 105 
AA4 7  THR B 113 ? SER B 118 ? THR C 113 SER C 118 
AA5 1  LYS C 25  ? THR C 28  ? LYS B 248 THR B 251 
AA5 2  GLU C 206 ? THR C 214 ? GLU B 429 THR B 437 
AA5 3  ASP C 225 ? CYS C 228 ? ASP B 448 CYS B 451 
AA5 4  VAL C 249 ? VAL C 255 ? VAL B 472 VAL B 478 
AA5 5  VAL C 262 ? HIS C 269 ? VAL B 485 HIS B 492 
AA5 6  TYR C 273 ? ALA C 277 ? TYR B 496 ALA B 500 
AA5 7  HIS C 282 ? ASP C 283 ? HIS B 505 ASP B 506 
AA5 8  TYR C 291 ? VAL C 298 ? TYR B 514 VAL B 521 
AA6 1  GLN D 3   ? SER D 7   ? GLN D 3   SER D 7   
AA6 2  LEU D 18  ? SER D 25  ? LEU D 18  SER D 25  
AA6 3  THR D 77  ? MET D 82  ? THR D 77  MET D 82  
AA6 4  PHE D 67  ? ASP D 72  ? PHE D 67  ASP D 72  
AA7 1  GLY D 10  ? GLN D 13  ? GLY D 10  GLN D 13  
AA7 2  ALA D 33  ? GLN D 39  ? ALA D 33  GLN D 39  
AA7 3  GLU D 46  ? ILE D 51  ? GLU D 46  ILE D 51  
AA7 4  THR D 57  ? TYR D 59  ? THR D 57  TYR D 59  
AA7 5  ALA D 91  ? LYS D 99  ? ALA D 91  LYS D 99  
AA7 6  TYR D 104 ? SER D 105 ? TYR D 104 SER D 105 
AA7 7  THR D 113 ? SER D 118 ? THR D 113 SER D 118 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N PHE A 27  ? N PHE A 250 O PHE A 210 ? O PHE A 433 
AA1 1  7  N THR A 28  ? N THR A 251 O HIS A 282 ? O HIS A 505 
AA1 2  3  N PHE A 211 ? N PHE A 434 O CYS A 228 ? O CYS A 451 
AA1 2  6  N LEU A 209 ? N LEU A 432 O VAL A 274 ? O VAL A 497 
AA1 4  5  N PHE A 254 ? N PHE A 477 O LEU A 263 ? O LEU A 486 
AA1 4  8  N LEU A 251 ? N LEU A 474 O SER A 296 ? O SER A 519 
AA1 5  6  N HIS A 269 ? N HIS A 492 O TYR A 273 ? O TYR A 496 
AA2 1  2  N ASP A 66  ? N ASP A 289 O ASN A 79  ? O ASN A 302 
AA2 1  6  N PHE A 63  ? N PHE A 286 O PHE A 160 ? O PHE A 383 
AA2 2  5  N MET A 78  ? N MET A 301 O VAL A 142 ? O VAL A 365 
AA2 3  4  N GLY A 109 ? N GLY A 332 O ALA A 126 ? O ALA A 349 
AA2 3  6  N THR A 112 ? N THR A 335 O LYS A 159 ? O LYS A 382 
AA2 4  5  N THR A 127 ? N THR A 350 O GLU A 145 ? O GLU A 368 
AA2 4  14 N THR A 121 ? N THR A 344 O GLY C 220 ? O GLY B 443 
AA2 6  7  N VAL A 165 ? N VAL A 388 O CYS A 218 ? O CYS A 441 
AA2 7  11 N GLY A 220 ? N GLY A 443 O THR C 121 ? O THR B 344 
AA2 8  9  N ASP C 66  ? N ASP B 289 O ASN C 79  ? O ASN B 302 
AA2 8  13 N PHE C 63  ? N PHE B 286 O PHE C 160 ? O PHE B 383 
AA2 9  12 N MET C 78  ? N MET B 301 O VAL C 142 ? O VAL B 365 
AA2 10 11 N GLY C 109 ? N GLY B 332 O ALA C 126 ? O ALA B 349 
AA2 10 13 N THR C 112 ? N THR B 335 O LYS C 159 ? O LYS B 382 
AA2 11 12 N THR C 127 ? N THR B 350 O GLU C 145 ? O GLU B 368 
AA2 13 14 N VAL C 165 ? N VAL B 388 O CYS C 218 ? O CYS B 441 
AA3 1  2  N SER B 7   ? N SER C 7   O SER B 21  ? O SER C 21  
AA3 2  3  N LEU B 18  ? N LEU C 18  O MET B 82  ? O MET C 82  
AA3 3  4  O GLN B 81  ? O GLN C 81  N THR B 68  ? N THR C 68  
AA4 1  7  N VAL B 12  ? N VAL C 12  O SER B 118 ? O SER C 118 
AA4 2  3  N TRP B 36  ? N TRP C 36  O VAL B 48  ? O VAL C 48  
AA4 2  5  N TYR B 37  ? N TYR C 37  O TYR B 94  ? O TYR C 94  
AA4 3  4  N GLY B 50  ? N GLY C 50  O ILE B 58  ? O ILE C 58  
AA4 5  6  N LYS B 99  ? N LYS C 99  O TYR B 104 ? O TYR C 104 
AA4 5  7  N ALA B 91  ? N ALA C 91  O VAL B 115 ? O VAL C 115 
AA5 1  2  N PHE C 27  ? N PHE B 250 O PHE C 210 ? O PHE B 433 
AA5 1  7  N THR C 28  ? N THR B 251 O HIS C 282 ? O HIS B 505 
AA5 2  3  N PHE C 211 ? N PHE B 434 O CYS C 228 ? O CYS B 451 
AA5 2  6  N GLN C 207 ? N GLN B 430 O VAL C 276 ? O VAL B 499 
AA5 4  5  N ALA C 250 ? N ALA B 473 O LEU C 268 ? O LEU B 491 
AA5 4  8  N LEU C 251 ? N LEU B 474 O SER C 296 ? O SER B 519 
AA5 5  6  N HIS C 269 ? N HIS B 492 O TYR C 273 ? O TYR B 496 
AA6 1  2  N GLN D 5   ? N GLN D 5   O ALA D 23  ? O ALA D 23  
AA6 2  3  N LEU D 18  ? N LEU D 18  O MET D 82  ? O MET D 82  
AA6 3  4  O GLN D 81  ? O GLN D 81  N THR D 68  ? N THR D 68  
AA7 1  7  N VAL D 12  ? N VAL D 12  O SER D 118 ? O SER D 118 
AA7 2  3  N TRP D 36  ? N TRP D 36  O VAL D 48  ? O VAL D 48  
AA7 2  5  N TYR D 37  ? N TYR D 37  O TYR D 94  ? O TYR D 94  
AA7 3  4  N GLY D 50  ? N GLY D 50  O ILE D 58  ? O ILE D 58  
AA7 5  6  N LYS D 99  ? N LYS D 99  O TYR D 104 ? O TYR D 104 
AA7 5  7  N TYR D 93  ? N TYR D 93  O THR D 113 ? O THR D 113 
# 
_atom_sites.entry_id                    8EN6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   0.013439 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008354 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007824 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . THR A 1 1   ? -2.910  -30.690 57.714  1.00 47.79 ?  224  THR A N   1 
ATOM   2    C CA  . THR A 1 1   ? -3.074  -29.362 58.286  1.00 48.26 ?  224  THR A CA  1 
ATOM   3    C C   . THR A 1 1   ? -3.944  -28.482 57.366  1.00 43.30 ?  224  THR A C   1 
ATOM   4    O O   . THR A 1 1   ? -4.781  -27.713 57.860  1.00 41.26 ?  224  THR A O   1 
ATOM   5    C CB  . THR A 1 1   ? -1.697  -28.683 58.552  1.00 58.16 ?  224  THR A CB  1 
ATOM   6    O OG1 . THR A 1 1   ? -1.842  -27.664 59.552  1.00 56.76 ?  224  THR A OG1 1 
ATOM   7    C CG2 . THR A 1 1   ? -1.121  -28.061 57.268  1.00 58.48 ?  224  THR A CG2 1 
ATOM   8    N N   . LYS A 1 2   ? -3.763  -28.605 56.041  1.00 38.69 ?  225  LYS A N   1 
ATOM   9    C CA  . LYS A 1 2   ? -4.605  -27.863 55.105  1.00 34.43 ?  225  LYS A CA  1 
ATOM   10   C C   . LYS A 1 2   ? -6.066  -28.242 55.317  1.00 27.05 ?  225  LYS A C   1 
ATOM   11   O O   . LYS A 1 2   ? -6.390  -29.441 55.318  1.00 26.20 ?  225  LYS A O   1 
ATOM   12   C CB  . LYS A 1 2   ? -4.230  -28.140 53.647  1.00 31.61 ?  225  LYS A CB  1 
ATOM   13   C CG  . LYS A 1 2   ? -5.075  -27.302 52.680  1.00 33.13 ?  225  LYS A CG  1 
ATOM   14   C CD  . LYS A 1 2   ? -4.929  -27.718 51.224  1.00 29.54 ?  225  LYS A CD  1 
ATOM   15   C CE  . LYS A 1 2   ? -3.580  -27.343 50.678  1.00 37.89 ?  225  LYS A CE  1 
ATOM   16   N NZ  . LYS A 1 2   ? -3.623  -27.481 49.201  1.00 36.72 ?  225  LYS A NZ  1 
ATOM   17   N N   . PRO A 1 3   ? -6.968  -27.269 55.473  1.00 25.94 ?  226  PRO A N   1 
ATOM   18   C CA  . PRO A 1 3   ? -8.369  -27.599 55.788  1.00 21.97 ?  226  PRO A CA  1 
ATOM   19   C C   . PRO A 1 3   ? -9.111  -28.191 54.595  1.00 19.45 ?  226  PRO A C   1 
ATOM   20   O O   . PRO A 1 3   ? -8.982  -27.731 53.458  1.00 20.94 ?  226  PRO A O   1 
ATOM   21   C CB  . PRO A 1 3   ? -8.979  -26.254 56.206  1.00 24.93 ?  226  PRO A CB  1 
ATOM   22   C CG  . PRO A 1 3   ? -7.832  -25.307 56.332  1.00 26.70 ?  226  PRO A CG  1 
ATOM   23   C CD  . PRO A 1 3   ? -6.713  -25.820 55.505  1.00 27.02 ?  226  PRO A CD  1 
ATOM   24   N N   . PHE A 1 4   ? -9.917  -29.191 54.888  1.00 17.97 ?  227  PHE A N   1 
ATOM   25   C CA  . PHE A 1 4   ? -10.742 -29.805 53.864  1.00 16.81 ?  227  PHE A CA  1 
ATOM   26   C C   . PHE A 1 4   ? -11.930 -28.906 53.536  1.00 16.66 ?  227  PHE A C   1 
ATOM   27   O O   . PHE A 1 4   ? -12.335 -28.050 54.324  1.00 16.82 ?  227  PHE A O   1 
ATOM   28   C CB  . PHE A 1 4   ? -11.219 -31.174 54.353  1.00 15.68 ?  227  PHE A CB  1 
ATOM   29   C CG  . PHE A 1 4   ? -12.099 -31.893 53.364  1.00 13.25 ?  227  PHE A CG  1 
ATOM   30   C CD1 . PHE A 1 4   ? -11.560 -32.356 52.165  1.00 15.46 ?  227  PHE A CD1 1 
ATOM   31   C CD2 . PHE A 1 4   ? -13.449 -32.068 53.620  1.00 15.14 ?  227  PHE A CD2 1 
ATOM   32   C CE1 . PHE A 1 4   ? -12.382 -32.999 51.224  1.00 14.78 ?  227  PHE A CE1 1 
ATOM   33   C CE2 . PHE A 1 4   ? -14.273 -32.715 52.711  1.00 15.79 ?  227  PHE A CE2 1 
ATOM   34   C CZ  . PHE A 1 4   ? -13.726 -33.202 51.493  1.00 14.30 ?  227  PHE A CZ  1 
ATOM   35   N N   . SER A 1 5   ? -12.461 -29.076 52.320  1.00 14.01 ?  228  SER A N   1 
ATOM   36   C CA  . SER A 1 5   ? -13.624 -28.322 51.863  1.00 14.63 ?  228  SER A CA  1 
ATOM   37   C C   . SER A 1 5   ? -14.163 -29.030 50.629  1.00 13.69 ?  228  SER A C   1 
ATOM   38   O O   . SER A 1 5   ? -13.501 -29.914 50.073  1.00 12.96 ?  228  SER A O   1 
ATOM   39   C CB  . SER A 1 5   ? -13.287 -26.863 51.535  1.00 14.89 ?  228  SER A CB  1 
ATOM   40   O OG  . SER A 1 5   ? -12.309 -26.783 50.510  1.00 13.22 ?  228  SER A OG  1 
ATOM   41   N N   . VAL A 1 6   ? -15.330 -28.598 50.171  1.00 13.08 ?  229  VAL A N   1 
ATOM   42   C CA  . VAL A 1 6   ? -15.851 -28.997 48.857  1.00 13.81 ?  229  VAL A CA  1 
ATOM   43   C C   . VAL A 1 6   ? -16.150 -27.731 48.065  1.00 14.57 ?  229  VAL A C   1 
ATOM   44   O O   . VAL A 1 6   ? -16.315 -26.646 48.652  1.00 14.06 ?  229  VAL A O   1 
ATOM   45   C CB  . VAL A 1 6   ? -17.102 -29.901 48.977  1.00 13.02 ?  229  VAL A CB  1 
ATOM   46   C CG1 . VAL A 1 6   ? -16.749 -31.202 49.756  1.00 14.12 ?  229  VAL A CG1 1 
ATOM   47   C CG2 . VAL A 1 6   ? -18.281 -29.153 49.637  1.00 16.10 ?  229  VAL A CG2 1 
ATOM   48   N N   . PRO A 1 7   ? -16.228 -27.818 46.730  1.00 12.91 ?  230  PRO A N   1 
ATOM   49   C CA  . PRO A 1 7   ? -16.422 -26.590 45.935  1.00 12.93 ?  230  PRO A CA  1 
ATOM   50   C C   . PRO A 1 7   ? -17.783 -25.962 46.157  1.00 14.15 ?  230  PRO A C   1 
ATOM   51   O O   . PRO A 1 7   ? -18.778 -26.633 46.452  1.00 16.80 ?  230  PRO A O   1 
ATOM   52   C CB  . PRO A 1 7   ? -16.259 -27.053 44.472  1.00 16.51 ?  230  PRO A CB  1 
ATOM   53   C CG  . PRO A 1 7   ? -15.883 -28.499 44.509  1.00 15.37 ?  230  PRO A CG  1 
ATOM   54   C CD  . PRO A 1 7   ? -16.034 -29.028 45.902  1.00 13.08 ?  230  PRO A CD  1 
ATOM   55   N N   . VAL A 1 8   ? -17.813 -24.636 46.020  1.00 12.64 ?  231  VAL A N   1 
ATOM   56   C CA  . VAL A 1 8   ? -19.079 -23.903 46.021  1.00 16.90 ?  231  VAL A CA  1 
ATOM   57   C C   . VAL A 1 8   ? -19.519 -23.941 44.563  1.00 16.40 ?  231  VAL A C   1 
ATOM   58   O O   . VAL A 1 8   ? -19.135 -23.085 43.743  1.00 19.89 ?  231  VAL A O   1 
ATOM   59   C CB  . VAL A 1 8   ? -18.916 -22.483 46.542  1.00 15.27 ?  231  VAL A CB  1 
ATOM   60   C CG1 . VAL A 1 8   ? -20.229 -21.733 46.544  1.00 19.38 ?  231  VAL A CG1 1 
ATOM   61   C CG2 . VAL A 1 8   ? -18.267 -22.554 47.973  1.00 15.18 ?  231  VAL A CG2 1 
ATOM   62   N N   . LEU A 1 9   ? -20.248 -24.975 44.222  1.00 12.81 ?  232  LEU A N   1 
ATOM   63   C CA  . LEU A 1 9   ? -20.855 -25.100 42.917  1.00 11.48 ?  232  LEU A CA  1 
ATOM   64   C C   . LEU A 1 9   ? -22.203 -25.750 43.146  1.00 13.33 ?  232  LEU A C   1 
ATOM   65   O O   . LEU A 1 9   ? -22.308 -26.693 43.949  1.00 11.79 ?  232  LEU A O   1 
ATOM   66   C CB  . LEU A 1 9   ? -20.043 -26.011 41.971  1.00 11.43 ?  232  LEU A CB  1 
ATOM   67   C CG  . LEU A 1 9   ? -18.620 -25.515 41.625  1.00 13.42 ?  232  LEU A CG  1 
ATOM   68   C CD1 . LEU A 1 9   ? -17.772 -26.681 41.030  1.00 12.17 ?  232  LEU A CD1 1 
ATOM   69   C CD2 . LEU A 1 9   ? -18.798 -24.349 40.637  1.00 16.39 ?  232  LEU A CD2 1 
ATOM   70   N N   . THR A 1 10  ? -23.211 -25.300 42.396  1.00 11.59 ?  233  THR A N   1 
ATOM   71   C CA  . THR A 1 10  ? -24.519 -25.940 42.449  1.00 10.63 ?  233  THR A CA  1 
ATOM   72   C C   . THR A 1 10  ? -24.498 -27.258 41.683  1.00 11.30 ?  233  THR A C   1 
ATOM   73   O O   . THR A 1 10  ? -23.577 -27.531 40.900  1.00 11.14 ?  233  THR A O   1 
ATOM   74   C CB  . THR A 1 10  ? -25.587 -25.028 41.856  1.00 13.76 ?  233  THR A CB  1 
ATOM   75   O OG1 . THR A 1 10  ? -25.413 -24.955 40.424  1.00 13.63 ?  233  THR A OG1 1 
ATOM   76   C CG2 . THR A 1 10  ? -25.464 -23.633 42.477  1.00 14.43 ?  233  THR A CG2 1 
ATOM   77   N N   . VAL A 1 11  ? -25.550 -28.065 41.875  1.00 9.25  ?  234  VAL A N   1 
ATOM   78   C CA  . VAL A 1 11  ? -25.646 -29.323 41.141  1.00 11.29 ?  234  VAL A CA  1 
ATOM   79   C C   . VAL A 1 11  ? -25.647 -29.047 39.635  1.00 11.50 ?  234  VAL A C   1 
ATOM   80   O O   . VAL A 1 11  ? -24.914 -29.694 38.867  1.00 11.13 ?  234  VAL A O   1 
ATOM   81   C CB  . VAL A 1 11  ? -26.898 -30.100 41.579  1.00 11.14 ?  234  VAL A CB  1 
ATOM   82   C CG1 . VAL A 1 11  ? -27.159 -31.314 40.675  1.00 11.65 ?  234  VAL A CG1 1 
ATOM   83   C CG2 . VAL A 1 11  ? -26.734 -30.510 43.061  1.00 13.64 ?  234  VAL A CG2 1 
ATOM   84   N N   . GLU A 1 12  ? -26.458 -28.065 39.190  1.00 11.55 ?  235  GLU A N   1 
ATOM   85   C CA  . GLU A 1 12  ? -26.548 -27.796 37.747  1.00 11.43 ?  235  GLU A CA  1 
ATOM   86   C C   . GLU A 1 12  ? -25.273 -27.173 37.166  1.00 11.07 ?  235  GLU A C   1 
ATOM   87   O O   . GLU A 1 12  ? -25.099 -27.186 35.929  1.00 11.79 ?  235  GLU A O   1 
ATOM   88   C CB  . GLU A 1 12  ? -27.750 -26.878 37.464  1.00 14.49 ?  235  GLU A CB  1 
ATOM   89   C CG  . GLU A 1 12  ? -29.040 -27.615 37.555  1.00 20.57 ?  235  GLU A CG  1 
ATOM   90   C CD  . GLU A 1 12  ? -30.277 -26.703 37.417  1.00 24.36 ?  235  GLU A CD  1 
ATOM   91   O OE1 . GLU A 1 12  ? -30.120 -25.511 37.018  1.00 23.39 ?  235  GLU A OE1 1 
ATOM   92   O OE2 . GLU A 1 12  ? -31.379 -27.210 37.730  1.00 22.15 -1 235  GLU A OE2 1 
ATOM   93   N N   . GLU A 1 13  ? -24.363 -26.647 38.011  1.00 10.23 ?  236  GLU A N   1 
ATOM   94   C CA  . GLU A 1 13  ? -23.085 -26.144 37.523  1.00 9.09  ?  236  GLU A CA  1 
ATOM   95   C C   . GLU A 1 13  ? -22.048 -27.252 37.317  1.00 9.13  ?  236  GLU A C   1 
ATOM   96   O O   . GLU A 1 13  ? -20.960 -26.977 36.816  1.00 11.47 ?  236  GLU A O   1 
ATOM   97   C CB  . GLU A 1 13  ? -22.502 -25.105 38.490  1.00 10.29 ?  236  GLU A CB  1 
ATOM   98   C CG  . GLU A 1 13  ? -23.224 -23.738 38.388  1.00 11.17 ?  236  GLU A CG  1 
ATOM   99   C CD  . GLU A 1 13  ? -22.834 -22.740 39.456  1.00 15.79 ?  236  GLU A CD  1 
ATOM   100  O OE1 . GLU A 1 13  ? -22.386 -23.121 40.547  1.00 13.13 ?  236  GLU A OE1 1 
ATOM   101  O OE2 . GLU A 1 13  ? -23.008 -21.524 39.197  1.00 17.72 -1 236  GLU A OE2 1 
ATOM   102  N N   . MET A 1 14  ? -22.337 -28.453 37.746  1.00 8.83  ?  237  MET A N   1 
ATOM   103  C CA  . MET A 1 14  ? -21.364 -29.559 37.779  1.00 8.01  ?  237  MET A CA  1 
ATOM   104  C C   . MET A 1 14  ? -21.681 -30.565 36.687  1.00 9.19  ?  237  MET A C   1 
ATOM   105  O O   . MET A 1 14  ? -22.674 -30.479 35.941  1.00 8.53  ?  237  MET A O   1 
ATOM   106  C CB  . MET A 1 14  ? -21.439 -30.176 39.179  1.00 8.91  ?  237  MET A CB  1 
ATOM   107  C CG  . MET A 1 14  ? -20.936 -29.224 40.256  1.00 9.28  ?  237  MET A CG  1 
ATOM   108  S SD  . MET A 1 14  ? -20.263 -29.946 41.766  1.00 10.13 ?  237  MET A SD  1 
ATOM   109  C CE  . MET A 1 14  ? -21.886 -30.200 42.546  1.00 12.29 ?  237  MET A CE  1 
ATOM   110  N N   . THR A 1 15  ? -20.810 -31.565 36.611  1.00 8.30  ?  238  THR A N   1 
ATOM   111  C CA  . THR A 1 15  ? -20.696 -32.488 35.480  1.00 8.11  ?  238  THR A CA  1 
ATOM   112  C C   . THR A 1 15  ? -20.677 -33.920 35.960  1.00 7.83  ?  238  THR A C   1 
ATOM   113  O O   . THR A 1 15  ? -20.019 -34.228 36.962  1.00 8.60  ?  238  THR A O   1 
ATOM   114  C CB  . THR A 1 15  ? -19.386 -32.185 34.683  1.00 7.99  ?  238  THR A CB  1 
ATOM   115  O OG1 . THR A 1 15  ? -19.326 -30.773 34.385  1.00 7.66  ?  238  THR A OG1 1 
ATOM   116  C CG2 . THR A 1 15  ? -19.394 -32.984 33.339  1.00 8.64  ?  238  THR A CG2 1 
ATOM   117  N N   . ASN A 1 16  ? -21.367 -34.809 35.223  1.00 7.70  ?  239  ASN A N   1 
ATOM   118  C CA  . ASN A 1 16  ? -21.294 -36.234 35.543  1.00 7.08  ?  239  ASN A CA  1 
ATOM   119  C C   . ASN A 1 16  ? -19.857 -36.727 35.335  1.00 8.35  ?  239  ASN A C   1 
ATOM   120  O O   . ASN A 1 16  ? -19.167 -36.319 34.400  1.00 8.72  ?  239  ASN A O   1 
ATOM   121  C CB  . ASN A 1 16  ? -22.258 -37.056 34.666  1.00 8.35  ?  239  ASN A CB  1 
ATOM   122  C CG  . ASN A 1 16  ? -22.691 -38.342 35.324  1.00 8.83  ?  239  ASN A CG  1 
ATOM   123  O OD1 . ASN A 1 16  ? -21.903 -39.265 35.475  1.00 9.02  ?  239  ASN A OD1 1 
ATOM   124  N ND2 . ASN A 1 16  ? -23.965 -38.392 35.771  1.00 9.05  ?  239  ASN A ND2 1 
ATOM   125  N N   . SER A 1 17  ? -19.398 -37.607 36.232  1.00 6.24  ?  240  SER A N   1 
ATOM   126  C CA  . SER A 1 17  ? -18.060 -38.180 36.129  1.00 7.70  ?  240  SER A CA  1 
ATOM   127  C C   . SER A 1 17  ? -18.024 -39.501 35.385  1.00 7.94  ?  240  SER A C   1 
ATOM   128  O O   . SER A 1 17  ? -16.949 -40.112 35.279  1.00 8.79  ?  240  SER A O   1 
ATOM   129  C CB  . SER A 1 17  ? -17.472 -38.346 37.559  1.00 7.96  ?  240  SER A CB  1 
ATOM   130  O OG  . SER A 1 17  ? -18.370 -39.083 38.374  1.00 8.12  ?  240  SER A OG  1 
ATOM   131  N N   . ARG A 1 18  ? -19.161 -39.953 34.856  1.00 6.52  ?  241  ARG A N   1 
ATOM   132  C CA  . ARG A 1 18  ? -19.215 -41.231 34.145  1.00 7.15  ?  241  ARG A CA  1 
ATOM   133  C C   . ARG A 1 18  ? -19.598 -41.081 32.694  1.00 8.65  ?  241  ARG A C   1 
ATOM   134  O O   . ARG A 1 18  ? -19.615 -42.073 31.959  1.00 8.91  ?  241  ARG A O   1 
ATOM   135  C CB  . ARG A 1 18  ? -20.193 -42.177 34.866  1.00 7.48  ?  241  ARG A CB  1 
ATOM   136  C CG  . ARG A 1 18  ? -19.632 -42.544 36.302  1.00 8.21  ?  241  ARG A CG  1 
ATOM   137  C CD  . ARG A 1 18  ? -20.566 -43.481 37.055  1.00 8.07  ?  241  ARG A CD  1 
ATOM   138  N NE  . ARG A 1 18  ? -20.628 -44.786 36.371  1.00 8.69  ?  241  ARG A NE  1 
ATOM   139  C CZ  . ARG A 1 18  ? -21.699 -45.554 36.250  1.00 8.93  ?  241  ARG A CZ  1 
ATOM   140  N NH1 . ARG A 1 18  ? -22.844 -45.289 36.903  1.00 8.96  ?  241  ARG A NH1 1 
ATOM   141  N NH2 . ARG A 1 18  ? -21.633 -46.619 35.458  1.00 10.54 ?  241  ARG A NH2 1 
ATOM   142  N N   . PHE A 1 19  ? -19.941 -39.883 32.255  1.00 7.25  ?  242  PHE A N   1 
ATOM   143  C CA  . PHE A 1 19  ? -20.286 -39.643 30.853  1.00 6.29  ?  242  PHE A CA  1 
ATOM   144  C C   . PHE A 1 19  ? -20.224 -38.129 30.682  1.00 6.66  ?  242  PHE A C   1 
ATOM   145  O O   . PHE A 1 19  ? -20.497 -37.408 31.646  1.00 8.03  ?  242  PHE A O   1 
ATOM   146  C CB  . PHE A 1 19  ? -21.705 -40.164 30.520  1.00 6.99  ?  242  PHE A CB  1 
ATOM   147  C CG  . PHE A 1 19  ? -21.950 -40.407 29.046  1.00 6.66  ?  242  PHE A CG  1 
ATOM   148  C CD1 . PHE A 1 19  ? -21.470 -41.563 28.411  1.00 7.10  ?  242  PHE A CD1 1 
ATOM   149  C CD2 . PHE A 1 19  ? -22.691 -39.481 28.293  1.00 8.18  ?  242  PHE A CD2 1 
ATOM   150  C CE1 . PHE A 1 19  ? -21.712 -41.766 27.027  1.00 8.28  ?  242  PHE A CE1 1 
ATOM   151  C CE2 . PHE A 1 19  ? -22.940 -39.704 26.933  1.00 9.69  ?  242  PHE A CE2 1 
ATOM   152  C CZ  . PHE A 1 19  ? -22.461 -40.829 26.312  1.00 9.51  ?  242  PHE A CZ  1 
ATOM   153  N N   . PRO A 1 20  ? -19.830 -37.608 29.495  1.00 7.24  ?  243  PRO A N   1 
ATOM   154  C CA  . PRO A 1 20  ? -19.575 -36.132 29.372  1.00 7.80  ?  243  PRO A CA  1 
ATOM   155  C C   . PRO A 1 20  ? -20.832 -35.281 29.178  1.00 8.02  ?  243  PRO A C   1 
ATOM   156  O O   . PRO A 1 20  ? -21.111 -34.732 28.105  1.00 8.07  ?  243  PRO A O   1 
ATOM   157  C CB  . PRO A 1 20  ? -18.645 -36.049 28.146  1.00 7.74  ?  243  PRO A CB  1 
ATOM   158  C CG  . PRO A 1 20  ? -19.033 -37.254 27.291  1.00 7.35  ?  243  PRO A CG  1 
ATOM   159  C CD  . PRO A 1 20  ? -19.325 -38.370 28.331  1.00 7.96  ?  243  PRO A CD  1 
ATOM   160  N N   . ILE A 1 21  ? -21.607 -35.170 30.250  1.00 8.04  ?  244  ILE A N   1 
ATOM   161  C CA  . ILE A 1 21  ? -22.888 -34.445 30.279  1.00 7.61  ?  244  ILE A CA  1 
ATOM   162  C C   . ILE A 1 21  ? -23.042 -33.784 31.648  1.00 7.07  ?  244  ILE A C   1 
ATOM   163  O O   . ILE A 1 21  ? -22.507 -34.260 32.654  1.00 8.30  ?  244  ILE A O   1 
ATOM   164  C CB  . ILE A 1 21  ? -24.083 -35.382 29.984  1.00 7.85  ?  244  ILE A CB  1 
ATOM   165  C CG1 . ILE A 1 21  ? -24.100 -36.566 30.952  1.00 7.69  ?  244  ILE A CG1 1 
ATOM   166  C CG2 . ILE A 1 21  ? -24.084 -35.897 28.519  1.00 7.27  ?  244  ILE A CG2 1 
ATOM   167  C CD1 . ILE A 1 21  ? -25.263 -37.517 30.697  1.00 10.03 ?  244  ILE A CD1 1 
ATOM   168  N N   . PRO A 1 22  ? -23.809 -32.705 31.750  1.00 8.29  ?  245  PRO A N   1 
ATOM   169  C CA  . PRO A 1 22  ? -23.982 -32.046 33.053  1.00 7.95  ?  245  PRO A CA  1 
ATOM   170  C C   . PRO A 1 22  ? -24.784 -32.895 34.010  1.00 8.17  ?  245  PRO A C   1 
ATOM   171  O O   . PRO A 1 22  ? -25.590 -33.746 33.598  1.00 10.27 ?  245  PRO A O   1 
ATOM   172  C CB  . PRO A 1 22  ? -24.761 -30.759 32.731  1.00 11.35 ?  245  PRO A CB  1 
ATOM   173  C CG  . PRO A 1 22  ? -24.901 -30.750 31.233  1.00 15.06 ?  245  PRO A CG  1 
ATOM   174  C CD  . PRO A 1 22  ? -24.465 -32.012 30.622  1.00 10.54 ?  245  PRO A CD  1 
ATOM   175  N N   . LEU A 1 23  ? -24.582 -32.597 35.307  1.00 8.47  ?  246  LEU A N   1 
ATOM   176  C CA  . LEU A 1 23  ? -25.490 -33.117 36.322  1.00 8.46  ?  246  LEU A CA  1 
ATOM   177  C C   . LEU A 1 23  ? -26.839 -32.438 36.188  1.00 8.23  ?  246  LEU A C   1 
ATOM   178  O O   . LEU A 1 23  ? -26.937 -31.263 35.782  1.00 10.99 ?  246  LEU A O   1 
ATOM   179  C CB  . LEU A 1 23  ? -24.966 -32.882 37.737  1.00 8.49  ?  246  LEU A CB  1 
ATOM   180  C CG  . LEU A 1 23  ? -23.711 -33.705 38.095  1.00 7.97  ?  246  LEU A CG  1 
ATOM   181  C CD1 . LEU A 1 23  ? -23.384 -33.395 39.572  1.00 9.08  ?  246  LEU A CD1 1 
ATOM   182  C CD2 . LEU A 1 23  ? -23.940 -35.181 37.943  1.00 9.37  ?  246  LEU A CD2 1 
ATOM   183  N N   . GLU A 1 24  ? -27.868 -33.176 36.563  1.00 8.20  ?  247  GLU A N   1 
ATOM   184  C CA  . GLU A 1 24  ? -29.225 -32.636 36.586  1.00 9.62  ?  247  GLU A CA  1 
ATOM   185  C C   . GLU A 1 24  ? -29.842 -32.583 37.974  1.00 13.42 ?  247  GLU A C   1 
ATOM   186  O O   . GLU A 1 24  ? -30.569 -31.606 38.287  1.00 12.87 ?  247  GLU A O   1 
ATOM   187  C CB  . GLU A 1 24  ? -30.107 -33.472 35.675  1.00 10.82 ?  247  GLU A CB  1 
ATOM   188  C CG  . GLU A 1 24  ? -29.728 -33.395 34.226  1.00 11.72 ?  247  GLU A CG  1 
ATOM   189  C CD  . GLU A 1 24  ? -30.195 -34.591 33.430  1.00 15.52 ?  247  GLU A CD  1 
ATOM   190  O OE1 . GLU A 1 24  ? -31.208 -35.250 33.847  1.00 14.25 ?  247  GLU A OE1 1 
ATOM   191  O OE2 . GLU A 1 24  ? -29.565 -34.891 32.358  1.00 13.11 -1 247  GLU A OE2 1 
ATOM   192  N N   . LYS A 1 25  ? -29.604 -33.599 38.793  1.00 10.22 ?  248  LYS A N   1 
ATOM   193  C CA  . LYS A 1 25  ? -30.396 -33.761 40.006  1.00 12.79 ?  248  LYS A CA  1 
ATOM   194  C C   . LYS A 1 25  ? -29.718 -34.725 40.984  1.00 13.35 ?  248  LYS A C   1 
ATOM   195  O O   . LYS A 1 25  ? -28.731 -35.406 40.666  1.00 11.24 ?  248  LYS A O   1 
ATOM   196  C CB  . LYS A 1 25  ? -31.823 -34.238 39.689  1.00 13.66 ?  248  LYS A CB  1 
ATOM   197  C CG  . LYS A 1 25  ? -31.922 -35.651 39.037  1.00 13.75 ?  248  LYS A CG  1 
ATOM   198  C CD  . LYS A 1 25  ? -33.143 -35.770 38.042  1.00 19.30 ?  248  LYS A CD  1 
ATOM   199  C CE  . LYS A 1 25  ? -32.869 -36.680 36.831  1.00 28.62 ?  248  LYS A CE  1 
ATOM   200  N NZ  . LYS A 1 25  ? -34.176 -37.278 36.336  1.00 27.82 ?  248  LYS A NZ  1 
ATOM   201  N N   . LEU A 1 26  ? -30.226 -34.729 42.214  1.00 10.94 ?  249  LEU A N   1 
ATOM   202  C CA  . LEU A 1 26  ? -29.770 -35.656 43.244  1.00 10.74 ?  249  LEU A CA  1 
ATOM   203  C C   . LEU A 1 26  ? -30.841 -36.719 43.460  1.00 12.87 ?  249  LEU A C   1 
ATOM   204  O O   . LEU A 1 26  ? -32.030 -36.410 43.479  1.00 12.87 ?  249  LEU A O   1 
ATOM   205  C CB  . LEU A 1 26  ? -29.493 -34.912 44.562  1.00 10.09 ?  249  LEU A CB  1 
ATOM   206  C CG  . LEU A 1 26  ? -28.469 -33.758 44.521  1.00 10.01 ?  249  LEU A CG  1 
ATOM   207  C CD1 . LEU A 1 26  ? -28.450 -32.990 45.862  1.00 12.55 ?  249  LEU A CD1 1 
ATOM   208  C CD2 . LEU A 1 26  ? -27.080 -34.281 44.162  1.00 12.38 ?  249  LEU A CD2 1 
ATOM   209  N N   . PHE A 1 27  ? -30.418 -37.973 43.619  1.00 12.17 ?  250  PHE A N   1 
ATOM   210  C CA  . PHE A 1 27  ? -31.356 -39.076 43.772  1.00 13.55 ?  250  PHE A CA  1 
ATOM   211  C C   . PHE A 1 27  ? -30.843 -40.007 44.860  1.00 15.17 ?  250  PHE A C   1 
ATOM   212  O O   . PHE A 1 27  ? -29.630 -40.257 44.933  1.00 13.84 ?  250  PHE A O   1 
ATOM   213  C CB  . PHE A 1 27  ? -31.504 -39.845 42.447  1.00 13.27 ?  250  PHE A CB  1 
ATOM   214  C CG  . PHE A 1 27  ? -32.294 -41.112 42.556  1.00 15.77 ?  250  PHE A CG  1 
ATOM   215  C CD1 . PHE A 1 27  ? -33.682 -41.070 42.513  1.00 16.08 ?  250  PHE A CD1 1 
ATOM   216  C CD2 . PHE A 1 27  ? -31.660 -42.356 42.677  1.00 17.21 ?  250  PHE A CD2 1 
ATOM   217  C CE1 . PHE A 1 27  ? -34.435 -42.237 42.603  1.00 19.53 ?  250  PHE A CE1 1 
ATOM   218  C CE2 . PHE A 1 27  ? -32.418 -43.548 42.776  1.00 20.94 ?  250  PHE A CE2 1 
ATOM   219  C CZ  . PHE A 1 27  ? -33.803 -43.478 42.741  1.00 20.37 ?  250  PHE A CZ  1 
ATOM   220  N N   . THR A 1 28  ? -31.751 -40.538 45.694  1.00 13.55 ?  251  THR A N   1 
ATOM   221  C CA  . THR A 1 28  ? -31.352 -41.621 46.598  1.00 15.35 ?  251  THR A CA  1 
ATOM   222  C C   . THR A 1 28  ? -32.280 -42.828 46.425  1.00 15.25 ?  251  THR A C   1 
ATOM   223  O O   . THR A 1 28  ? -33.463 -42.687 46.098  1.00 16.46 ?  251  THR A O   1 
ATOM   224  C CB  . THR A 1 28  ? -31.304 -41.111 48.081  1.00 14.68 ?  251  THR A CB  1 
ATOM   225  O OG1 . THR A 1 28  ? -30.752 -42.142 48.921  1.00 14.82 ?  251  THR A OG1 1 
ATOM   226  C CG2 . THR A 1 28  ? -32.702 -40.661 48.573  1.00 16.29 ?  251  THR A CG2 1 
ATOM   227  N N   . GLY A 1 29  ? -31.727 -44.036 46.600  1.00 16.10 ?  252  GLY A N   1 
ATOM   228  C CA  . GLY A 1 29  ? -32.551 -45.226 46.577  1.00 16.39 ?  252  GLY A CA  1 
ATOM   229  C C   . GLY A 1 29  ? -31.772 -46.363 47.191  1.00 16.52 ?  252  GLY A C   1 
ATOM   230  O O   . GLY A 1 29  ? -30.558 -46.265 47.420  1.00 16.84 ?  252  GLY A O   1 
ATOM   231  N N   . PRO A 1 30  ? -32.454 -47.460 47.502  1.00 18.59 ?  253  PRO A N   1 
ATOM   232  C CA  . PRO A 1 30  ? -31.745 -48.626 48.038  1.00 18.82 ?  253  PRO A CA  1 
ATOM   233  C C   . PRO A 1 30  ? -30.865 -49.237 46.960  1.00 19.77 ?  253  PRO A C   1 
ATOM   234  O O   . PRO A 1 30  ? -31.184 -49.161 45.772  1.00 20.56 ?  253  PRO A O   1 
ATOM   235  C CB  . PRO A 1 30  ? -32.881 -49.595 48.420  1.00 19.84 ?  253  PRO A CB  1 
ATOM   236  C CG  . PRO A 1 30  ? -34.036 -49.181 47.596  1.00 20.71 ?  253  PRO A CG  1 
ATOM   237  C CD  . PRO A 1 30  ? -33.907 -47.685 47.330  1.00 18.98 ?  253  PRO A CD  1 
ATOM   238  N N   . SER A 1 31  ? -29.780 -49.899 47.395  1.00 19.75 ?  254  SER A N   1 
ATOM   239  C CA  . SER A 1 31  ? -28.805 -50.445 46.460  1.00 20.38 ?  254  SER A CA  1 
ATOM   240  C C   . SER A 1 31  ? -28.274 -51.801 46.943  1.00 25.38 ?  254  SER A C   1 
ATOM   241  O O   . SER A 1 31  ? -27.215 -52.251 46.484  1.00 27.03 ?  254  SER A O   1 
ATOM   242  C CB  . SER A 1 31  ? -27.646 -49.441 46.249  1.00 19.68 ?  254  SER A CB  1 
ATOM   243  O OG  . SER A 1 31  ? -26.928 -49.240 47.454  1.00 20.09 ?  254  SER A OG  1 
ATOM   244  N N   . SER A 1 32  ? -28.987 -52.469 47.846  1.00 24.73 ?  255  SER A N   1 
ATOM   245  C CA  . SER A 1 32  ? -28.546 -53.791 48.284  1.00 27.74 ?  255  SER A CA  1 
ATOM   246  C C   . SER A 1 32  ? -28.766 -54.865 47.217  1.00 28.32 ?  255  SER A C   1 
ATOM   247  O O   . SER A 1 32  ? -28.113 -55.910 47.272  1.00 35.16 ?  255  SER A O   1 
ATOM   248  C CB  . SER A 1 32  ? -29.244 -54.141 49.600  1.00 34.05 ?  255  SER A CB  1 
ATOM   249  O OG  . SER A 1 32  ? -30.647 -53.991 49.482  1.00 33.32 ?  255  SER A OG  1 
ATOM   250  N N   . ALA A 1 33  ? -29.602 -54.612 46.215  1.00 28.37 ?  256  ALA A N   1 
ATOM   251  C CA  . ALA A 1 33  ? -29.945 -55.604 45.203  1.00 31.50 ?  256  ALA A CA  1 
ATOM   252  C C   . ALA A 1 33  ? -29.048 -55.566 43.960  1.00 34.53 ?  256  ALA A C   1 
ATOM   253  O O   . ALA A 1 33  ? -29.337 -56.259 42.979  1.00 37.92 ?  256  ALA A O   1 
ATOM   254  C CB  . ALA A 1 33  ? -31.406 -55.421 44.786  1.00 31.39 ?  256  ALA A CB  1 
ATOM   255  N N   . PHE A 1 34  ? -27.979 -54.779 43.963  1.00 31.21 ?  257  PHE A N   1 
ATOM   256  C CA  . PHE A 1 34  ? -27.018 -54.789 42.865  1.00 26.41 ?  257  PHE A CA  1 
ATOM   257  C C   . PHE A 1 34  ? -25.672 -54.344 43.426  1.00 24.96 ?  257  PHE A C   1 
ATOM   258  O O   . PHE A 1 34  ? -25.581 -53.901 44.568  1.00 23.92 ?  257  PHE A O   1 
ATOM   259  C CB  . PHE A 1 34  ? -27.488 -53.909 41.700  1.00 28.25 ?  257  PHE A CB  1 
ATOM   260  C CG  . PHE A 1 34  ? -27.966 -52.555 42.120  1.00 28.28 ?  257  PHE A CG  1 
ATOM   261  C CD1 . PHE A 1 34  ? -27.084 -51.500 42.220  1.00 23.60 ?  257  PHE A CD1 1 
ATOM   262  C CD2 . PHE A 1 34  ? -29.314 -52.339 42.455  1.00 28.23 ?  257  PHE A CD2 1 
ATOM   263  C CE1 . PHE A 1 34  ? -27.519 -50.281 42.627  1.00 22.11 ?  257  PHE A CE1 1 
ATOM   264  C CE2 . PHE A 1 34  ? -29.758 -51.098 42.855  1.00 27.38 ?  257  PHE A CE2 1 
ATOM   265  C CZ  . PHE A 1 34  ? -28.859 -50.061 42.947  1.00 27.92 ?  257  PHE A CZ  1 
ATOM   266  N N   . VAL A 1 35  ? -24.614 -54.511 42.631  1.00 23.18 ?  258  VAL A N   1 
ATOM   267  C CA  . VAL A 1 35  ? -23.259 -54.127 43.035  1.00 19.48 ?  258  VAL A CA  1 
ATOM   268  C C   . VAL A 1 35  ? -22.990 -52.733 42.496  1.00 19.58 ?  258  VAL A C   1 
ATOM   269  O O   . VAL A 1 35  ? -23.145 -52.495 41.289  1.00 18.19 ?  258  VAL A O   1 
ATOM   270  C CB  . VAL A 1 35  ? -22.211 -55.105 42.487  1.00 22.05 ?  258  VAL A CB  1 
ATOM   271  C CG1 . VAL A 1 35  ? -20.836 -54.695 42.919  1.00 22.77 ?  258  VAL A CG1 1 
ATOM   272  C CG2 . VAL A 1 35  ? -22.502 -56.545 42.904  1.00 26.12 ?  258  VAL A CG2 1 
ATOM   273  N N   . VAL A 1 36  ? -22.568 -51.818 43.364  1.00 13.48 ?  259  VAL A N   1 
ATOM   274  C CA  . VAL A 1 36  ? -22.284 -50.431 42.959  1.00 13.65 ?  259  VAL A CA  1 
ATOM   275  C C   . VAL A 1 36  ? -20.775 -50.307 42.934  1.00 13.94 ?  259  VAL A C   1 
ATOM   276  O O   . VAL A 1 36  ? -20.132 -50.106 43.966  1.00 14.69 ?  259  VAL A O   1 
ATOM   277  C CB  . VAL A 1 36  ? -22.905 -49.402 43.921  1.00 13.50 ?  259  VAL A CB  1 
ATOM   278  C CG1 . VAL A 1 36  ? -22.477 -47.999 43.481  1.00 13.66 ?  259  VAL A CG1 1 
ATOM   279  C CG2 . VAL A 1 36  ? -24.415 -49.552 43.925  1.00 16.74 ?  259  VAL A CG2 1 
ATOM   280  N N   . GLN A 1 37  ? -20.188 -50.451 41.760  1.00 11.33 ?  260  GLN A N   1 
ATOM   281  C CA  . GLN A 1 37  ? -18.736 -50.479 41.657  1.00 12.08 ?  260  GLN A CA  1 
ATOM   282  C C   . GLN A 1 37  ? -18.317 -49.705 40.414  1.00 11.22 ?  260  GLN A C   1 
ATOM   283  O O   . GLN A 1 37  ? -17.500 -50.179 39.626  1.00 9.71  ?  260  GLN A O   1 
ATOM   284  C CB  . GLN A 1 37  ? -18.228 -51.942 41.631  1.00 12.01 ?  260  GLN A CB  1 
ATOM   285  C CG  . GLN A 1 37  ? -16.728 -52.034 41.804  1.00 12.62 ?  260  GLN A CG  1 
ATOM   286  C CD  . GLN A 1 37  ? -16.263 -53.451 42.173  1.00 13.44 ?  260  GLN A CD  1 
ATOM   287  O OE1 . GLN A 1 37  ? -17.044 -54.417 42.057  1.00 14.76 ?  260  GLN A OE1 1 
ATOM   288  N NE2 . GLN A 1 37  ? -15.000 -53.574 42.605  1.00 13.94 ?  260  GLN A NE2 1 
ATOM   289  N N   . PRO A 1 38  ? -18.798 -48.478 40.216  1.00 8.65  ?  261  PRO A N   1 
ATOM   290  C CA  . PRO A 1 38  ? -18.301 -47.723 39.056  1.00 8.64  ?  261  PRO A CA  1 
ATOM   291  C C   . PRO A 1 38  ? -16.804 -47.436 39.158  1.00 9.82  ?  261  PRO A C   1 
ATOM   292  O O   . PRO A 1 38  ? -16.230 -47.309 40.259  1.00 9.32  ?  261  PRO A O   1 
ATOM   293  C CB  . PRO A 1 38  ? -19.106 -46.411 39.099  1.00 9.88  ?  261  PRO A CB  1 
ATOM   294  C CG  . PRO A 1 38  ? -19.336 -46.193 40.619  1.00 10.19 ?  261  PRO A CG  1 
ATOM   295  C CD  . PRO A 1 38  ? -19.645 -47.645 41.100  1.00 9.78  ?  261  PRO A CD  1 
ATOM   296  N N   . GLN A 1 39  ? -16.159 -47.281 37.986  1.00 8.46  ?  262  GLN A N   1 
ATOM   297  C CA  . GLN A 1 39  ? -14.720 -47.039 37.939  1.00 8.98  ?  262  GLN A CA  1 
ATOM   298  C C   . GLN A 1 39  ? -14.340 -45.622 37.541  1.00 8.92  ?  262  GLN A C   1 
ATOM   299  O O   . GLN A 1 39  ? -13.208 -45.186 37.818  1.00 9.00  ?  262  GLN A O   1 
ATOM   300  C CB  . GLN A 1 39  ? -14.024 -48.035 36.974  1.00 9.64  ?  262  GLN A CB  1 
ATOM   301  C CG  . GLN A 1 39  ? -14.249 -49.521 37.432  1.00 8.61  ?  262  GLN A CG  1 
ATOM   302  C CD  . GLN A 1 39  ? -13.625 -49.743 38.815  1.00 9.29  ?  262  GLN A CD  1 
ATOM   303  O OE1 . GLN A 1 39  ? -12.429 -49.503 39.003  1.00 10.70 ?  262  GLN A OE1 1 
ATOM   304  N NE2 . GLN A 1 39  ? -14.444 -50.172 39.762  1.00 9.63  ?  262  GLN A NE2 1 
ATOM   305  N N   . ASN A 1 40  ? -15.238 -44.902 36.858  1.00 7.31  ?  263  ASN A N   1 
ATOM   306  C CA  . ASN A 1 40  ? -15.068 -43.467 36.652  1.00 7.11  ?  263  ASN A CA  1 
ATOM   307  C C   . ASN A 1 40  ? -15.766 -42.717 37.808  1.00 8.06  ?  263  ASN A C   1 
ATOM   308  O O   . ASN A 1 40  ? -16.702 -43.237 38.426  1.00 8.98  ?  263  ASN A O   1 
ATOM   309  C CB  . ASN A 1 40  ? -15.654 -43.092 35.279  1.00 8.20  ?  263  ASN A CB  1 
ATOM   310  C CG  . ASN A 1 40  ? -14.804 -43.587 34.157  1.00 7.86  ?  263  ASN A CG  1 
ATOM   311  O OD1 . ASN A 1 40  ? -13.574 -43.457 34.203  1.00 9.48  ?  263  ASN A OD1 1 
ATOM   312  N ND2 . ASN A 1 40  ? -15.438 -44.093 33.114  1.00 7.67  ?  263  ASN A ND2 1 
ATOM   313  N N   . GLY A 1 41  ? -15.282 -41.504 38.113  1.00 6.86  ?  264  GLY A N   1 
ATOM   314  C CA  . GLY A 1 41  ? -15.825 -40.740 39.226  1.00 7.53  ?  264  GLY A CA  1 
ATOM   315  C C   . GLY A 1 41  ? -15.408 -41.288 40.577  1.00 8.30  ?  264  GLY A C   1 
ATOM   316  O O   . GLY A 1 41  ? -16.182 -41.208 41.544  1.00 9.08  ?  264  GLY A O   1 
ATOM   317  N N   . ARG A 1 42  ? -14.199 -41.837 40.663  1.00 8.58  ?  265  ARG A N   1 
ATOM   318  C CA  . ARG A 1 42  ? -13.701 -42.451 41.911  1.00 8.59  ?  265  ARG A CA  1 
ATOM   319  C C   . ARG A 1 42  ? -12.455 -41.707 42.391  1.00 9.94  ?  265  ARG A C   1 
ATOM   320  O O   . ARG A 1 42  ? -11.430 -41.630 41.679  1.00 8.78  ?  265  ARG A O   1 
ATOM   321  C CB  . ARG A 1 42  ? -13.409 -43.948 41.705  1.00 8.62  ?  265  ARG A CB  1 
ATOM   322  C CG  . ARG A 1 42  ? -14.623 -44.780 41.269  1.00 7.22  ?  265  ARG A CG  1 
ATOM   323  C CD  . ARG A 1 42  ? -15.801 -44.756 42.260  1.00 8.99  ?  265  ARG A CD  1 
ATOM   324  N NE  . ARG A 1 42  ? -15.380 -45.342 43.559  1.00 11.91 ?  265  ARG A NE  1 
ATOM   325  C CZ  . ARG A 1 42  ? -15.505 -46.626 43.903  1.00 12.01 ?  265  ARG A CZ  1 
ATOM   326  N NH1 . ARG A 1 42  ? -16.048 -47.534 43.095  1.00 10.06 ?  265  ARG A NH1 1 
ATOM   327  N NH2 . ARG A 1 42  ? -15.105 -47.013 45.133  1.00 11.35 ?  265  ARG A NH2 1 
ATOM   328  N N   . CYS A 1 43  ? -12.547 -41.148 43.605  1.00 9.55  ?  266  CYS A N   1 
ATOM   329  C CA  . CYS A 1 43  ? -11.446 -40.341 44.121  1.00 9.55  ?  266  CYS A CA  1 
ATOM   330  C C   . CYS A 1 43  ? -11.595 -40.266 45.632  1.00 10.73 ?  266  CYS A C   1 
ATOM   331  O O   . CYS A 1 43  ? -12.719 -40.136 46.113  1.00 11.23 ?  266  CYS A O   1 
ATOM   332  C CB  . CYS A 1 43  ? -11.461 -38.933 43.486  1.00 10.27 ?  266  CYS A CB  1 
ATOM   333  S SG  . CYS A 1 43  ? -10.072 -37.851 43.935  1.00 12.18 ?  266  CYS A SG  1 
ATOM   334  N N   . THR A 1 44  ? -10.466 -40.339 46.361  1.00 10.50 ?  267  THR A N   1 
ATOM   335  C CA  . THR A 1 44  ? -10.557 -40.130 47.816  1.00 12.80 ?  267  THR A CA  1 
ATOM   336  C C   . THR A 1 44  ? -10.666 -38.643 48.164  1.00 12.46 ?  267  THR A C   1 
ATOM   337  O O   . THR A 1 44  ? -10.363 -37.760 47.352  1.00 13.26 ?  267  THR A O   1 
ATOM   338  C CB  . THR A 1 44  ? -9.355  -40.744 48.540  1.00 11.17 ?  267  THR A CB  1 
ATOM   339  O OG1 . THR A 1 44  ? -8.161  -40.020 48.212  1.00 12.46 ?  267  THR A OG1 1 
ATOM   340  C CG2 . THR A 1 44  ? -9.218  -42.185 48.119  1.00 12.68 ?  267  THR A CG2 1 
ATOM   341  N N   . THR A 1 45  ? -11.129 -38.357 49.405  1.00 12.08 ?  268  THR A N   1 
ATOM   342  C CA  . THR A 1 45  ? -11.263 -36.942 49.751  1.00 11.00 ?  268  THR A CA  1 
ATOM   343  C C   . THR A 1 45  ? -9.907  -36.253 49.822  1.00 12.43 ?  268  THR A C   1 
ATOM   344  O O   . THR A 1 45  ? -9.860  -35.029 49.696  1.00 13.74 ?  268  THR A O   1 
ATOM   345  C CB  . THR A 1 45  ? -12.024 -36.742 51.072  1.00 13.37 ?  268  THR A CB  1 
ATOM   346  O OG1 . THR A 1 45  ? -11.326 -37.425 52.140  1.00 13.99 ?  268  THR A OG1 1 
ATOM   347  C CG2 . THR A 1 45  ? -13.467 -37.263 50.956  1.00 12.83 ?  268  THR A CG2 1 
ATOM   348  N N   . ASP A 1 46  ? -8.810  -36.997 50.051  1.00 14.25 ?  269  ASP A N   1 
ATOM   349  C CA  . ASP A 1 46  ? -7.501  -36.381 50.052  1.00 14.10 ?  269  ASP A CA  1 
ATOM   350  C C   . ASP A 1 46  ? -6.811  -36.459 48.691  1.00 15.14 ?  269  ASP A C   1 
ATOM   351  O O   . ASP A 1 46  ? -5.607  -36.221 48.608  1.00 16.49 ?  269  ASP A O   1 
ATOM   352  C CB  . ASP A 1 46  ? -6.609  -36.941 51.191  1.00 17.02 ?  269  ASP A CB  1 
ATOM   353  C CG  . ASP A 1 46  ? -6.393  -38.445 51.159  1.00 24.87 ?  269  ASP A CG  1 
ATOM   354  O OD1 . ASP A 1 46  ? -6.964  -39.210 50.340  1.00 22.27 ?  269  ASP A OD1 1 
ATOM   355  O OD2 . ASP A 1 46  ? -5.556  -38.883 51.989  1.00 26.00 -1 269  ASP A OD2 1 
ATOM   356  N N   . GLY A 1 47  ? -7.556  -36.712 47.607  1.00 13.26 ?  270  GLY A N   1 
ATOM   357  C CA  . GLY A 1 47  ? -7.007  -36.488 46.277  1.00 12.77 ?  270  GLY A CA  1 
ATOM   358  C C   . GLY A 1 47  ? -6.370  -37.661 45.560  1.00 13.06 ?  270  GLY A C   1 
ATOM   359  O O   . GLY A 1 47  ? -5.641  -37.423 44.588  1.00 15.50 ?  270  GLY A O   1 
ATOM   360  N N   . VAL A 1 48  ? -6.622  -38.893 45.967  1.00 11.71 ?  271  VAL A N   1 
ATOM   361  C CA  . VAL A 1 48  ? -6.084  -40.061 45.265  1.00 12.46 ?  271  VAL A CA  1 
ATOM   362  C C   . VAL A 1 48  ? -7.110  -40.607 44.271  1.00 11.75 ?  271  VAL A C   1 
ATOM   363  O O   . VAL A 1 48  ? -8.182  -41.106 44.659  1.00 11.40 ?  271  VAL A O   1 
ATOM   364  C CB  . VAL A 1 48  ? -5.671  -41.157 46.255  1.00 11.54 ?  271  VAL A CB  1 
ATOM   365  C CG1 . VAL A 1 48  ? -5.108  -42.359 45.505  1.00 14.14 ?  271  VAL A CG1 1 
ATOM   366  C CG2 . VAL A 1 48  ? -4.681  -40.618 47.254  1.00 13.92 ?  271  VAL A CG2 1 
ATOM   367  N N   . LEU A 1 49  ? -6.767  -40.532 42.973  1.00 11.91 ?  272  LEU A N   1 
ATOM   368  C CA  . LEU A 1 49  ? -7.668  -41.056 41.953  1.00 12.84 ?  272  LEU A CA  1 
ATOM   369  C C   . LEU A 1 49  ? -7.676  -42.580 41.988  1.00 11.96 ?  272  LEU A C   1 
ATOM   370  O O   . LEU A 1 49  ? -6.648  -43.236 42.255  1.00 14.70 ?  272  LEU A O   1 
ATOM   371  C CB  . LEU A 1 49  ? -7.236  -40.597 40.549  1.00 12.30 ?  272  LEU A CB  1 
ATOM   372  C CG  . LEU A 1 49  ? -7.049  -39.099 40.444  1.00 11.64 ?  272  LEU A CG  1 
ATOM   373  C CD1 . LEU A 1 49  ? -6.476  -38.776 39.038  1.00 14.39 ?  272  LEU A CD1 1 
ATOM   374  C CD2 . LEU A 1 49  ? -8.343  -38.297 40.680  1.00 13.06 ?  272  LEU A CD2 1 
ATOM   375  N N   . LEU A 1 50  ? -8.837  -43.151 41.709  1.00 10.85 ?  273  LEU A N   1 
ATOM   376  C CA  . LEU A 1 50  ? -9.047  -44.594 41.760  1.00 10.57 ?  273  LEU A CA  1 
ATOM   377  C C   . LEU A 1 50  ? -9.625  -45.126 40.449  1.00 10.63 ?  273  LEU A C   1 
ATOM   378  O O   . LEU A 1 50  ? -10.196 -44.374 39.650  1.00 10.86 ?  273  LEU A O   1 
ATOM   379  C CB  . LEU A 1 50  ? -10.010 -44.984 42.909  1.00 12.60 ?  273  LEU A CB  1 
ATOM   380  C CG  . LEU A 1 50  ? -9.682  -44.425 44.309  1.00 13.11 ?  273  LEU A CG  1 
ATOM   381  C CD1 . LEU A 1 50  ? -10.822 -44.714 45.281  1.00 12.74 ?  273  LEU A CD1 1 
ATOM   382  C CD2 . LEU A 1 50  ? -8.393  -45.070 44.842  1.00 16.45 ?  273  LEU A CD2 1 
ATOM   383  N N   . GLY A 1 51  ? -9.538  -46.442 40.256  1.00 10.09 ?  274  GLY A N   1 
ATOM   384  C CA  . GLY A 1 51  ? -10.219 -47.062 39.123  1.00 10.16 ?  274  GLY A CA  1 
ATOM   385  C C   . GLY A 1 51  ? -9.687  -46.577 37.789  1.00 10.59 ?  274  GLY A C   1 
ATOM   386  O O   . GLY A 1 51  ? -8.471  -46.597 37.552  1.00 10.70 ?  274  GLY A O   1 
ATOM   387  N N   . THR A 1 52  ? -10.598 -46.150 36.892  1.00 8.94  ?  275  THR A N   1 
ATOM   388  C CA  . THR A 1 52  ? -10.217 -45.581 35.599  1.00 9.32  ?  275  THR A CA  1 
ATOM   389  C C   . THR A 1 52  ? -10.379 -44.057 35.588  1.00 9.53  ?  275  THR A C   1 
ATOM   390  O O   . THR A 1 52  ? -10.449 -43.455 34.509  1.00 9.19  ?  275  THR A O   1 
ATOM   391  C CB  . THR A 1 52  ? -11.026 -46.209 34.446  1.00 7.46  ?  275  THR A CB  1 
ATOM   392  O OG1 . THR A 1 52  ? -12.423 -46.023 34.688  1.00 8.87  ?  275  THR A OG1 1 
ATOM   393  C CG2 . THR A 1 52  ? -10.739 -47.739 34.332  1.00 8.97  ?  275  THR A CG2 1 
ATOM   394  N N   . THR A 1 53  ? -10.356 -43.424 36.757  1.00 9.11  ?  276  THR A N   1 
ATOM   395  C CA  . THR A 1 53  ? -10.731 -42.005 36.850  1.00 9.45  ?  276  THR A CA  1 
ATOM   396  C C   . THR A 1 53  ? -9.578  -41.100 36.430  1.00 11.15 ?  276  THR A C   1 
ATOM   397  O O   . THR A 1 53  ? -8.435  -41.245 36.896  1.00 10.11 ?  276  THR A O   1 
ATOM   398  C CB  . THR A 1 53  ? -11.205 -41.709 38.283  1.00 9.01  ?  276  THR A CB  1 
ATOM   399  O OG1 . THR A 1 53  ? -12.408 -42.455 38.516  1.00 8.99  ?  276  THR A OG1 1 
ATOM   400  C CG2 . THR A 1 53  ? -11.517 -40.238 38.495  1.00 9.13  ?  276  THR A CG2 1 
ATOM   401  N N   . GLN A 1 54  ? -9.867  -40.165 35.532  1.00 8.63  ?  277  GLN A N   1 
ATOM   402  C CA  . GLN A 1 54  ? -8.950  -39.105 35.161  1.00 9.94  ?  277  GLN A CA  1 
ATOM   403  C C   . GLN A 1 54  ? -9.656  -37.748 35.283  1.00 8.77  ?  277  GLN A C   1 
ATOM   404  O O   . GLN A 1 54  ? -10.808 -37.680 35.726  1.00 8.62  ?  277  GLN A O   1 
ATOM   405  C CB  . GLN A 1 54  ? -8.357  -39.292 33.746  1.00 9.12  ?  277  GLN A CB  1 
ATOM   406  C CG  . GLN A 1 54  ? -9.381  -39.628 32.652  1.00 9.30  ?  277  GLN A CG  1 
ATOM   407  C CD  . GLN A 1 54  ? -10.026 -38.384 32.172  1.00 12.07 ?  277  GLN A CD  1 
ATOM   408  O OE1 . GLN A 1 54  ? -9.388  -37.468 31.627  1.00 9.69  ?  277  GLN A OE1 1 
ATOM   409  N NE2 . GLN A 1 54  ? -11.352 -38.334 32.354  1.00 7.99  ?  277  GLN A NE2 1 
ATOM   410  N N   . LEU A 1 55  ? -8.940  -36.641 34.965  1.00 7.66  ?  278  LEU A N   1 
ATOM   411  C CA  . LEU A 1 55  ? -9.385  -35.317 35.433  1.00 8.24  ?  278  LEU A CA  1 
ATOM   412  C C   . LEU A 1 55  ? -10.371 -34.562 34.515  1.00 10.41 ?  278  LEU A C   1 
ATOM   413  O O   . LEU A 1 55  ? -11.175 -33.775 35.040  1.00 11.04 ?  278  LEU A O   1 
ATOM   414  C CB  . LEU A 1 55  ? -8.167  -34.429 35.683  1.00 11.16 ?  278  LEU A CB  1 
ATOM   415  C CG  . LEU A 1 55  ? -7.304  -34.901 36.872  1.00 10.15 ?  278  LEU A CG  1 
ATOM   416  C CD1 . LEU A 1 55  ? -5.992  -34.150 36.797  1.00 12.51 ?  278  LEU A CD1 1 
ATOM   417  C CD2 . LEU A 1 55  ? -7.999  -34.656 38.230  1.00 11.36 ?  278  LEU A CD2 1 
ATOM   418  N N   . SER A 1 56  ? -10.301 -34.743 33.206  1.00 12.49 ?  279  SER A N   1 
ATOM   419  C CA  . SER A 1 56  ? -11.221 -33.859 32.452  1.00 12.86 ?  279  SER A CA  1 
ATOM   420  C C   . SER A 1 56  ? -12.459 -34.594 31.977  1.00 9.16  ?  279  SER A C   1 
ATOM   421  O O   . SER A 1 56  ? -12.361 -35.718 31.489  1.00 9.33  ?  279  SER A O   1 
ATOM   422  C CB  . SER A 1 56  ? -10.544 -33.258 31.229  1.00 12.67 ?  279  SER A CB  1 
ATOM   423  O OG  . SER A 1 56  ? -11.513 -32.488 30.448  1.00 11.76 ?  279  SER A OG  1 
ATOM   424  N N   . PRO A 1 57  ? -13.648 -34.014 32.097  1.00 9.03  ?  280  PRO A N   1 
ATOM   425  C CA  . PRO A 1 57  ? -14.839 -34.760 31.705  1.00 9.45  ?  280  PRO A CA  1 
ATOM   426  C C   . PRO A 1 57  ? -14.966 -34.991 30.221  1.00 8.68  ?  280  PRO A C   1 
ATOM   427  O O   . PRO A 1 57  ? -15.686 -35.909 29.811  1.00 9.91  ?  280  PRO A O   1 
ATOM   428  C CB  . PRO A 1 57  ? -16.003 -33.904 32.229  1.00 13.69 ?  280  PRO A CB  1 
ATOM   429  C CG  . PRO A 1 57  ? -15.460 -32.538 32.251  1.00 10.14 ?  280  PRO A CG  1 
ATOM   430  C CD  . PRO A 1 57  ? -14.031 -32.706 32.726  1.00 10.27 ?  280  PRO A CD  1 
ATOM   431  N N   . VAL A 1 58  ? -14.265 -34.224 29.381  1.00 8.44  ?  281  VAL A N   1 
ATOM   432  C CA  . VAL A 1 58  ? -14.436 -34.429 27.949  1.00 8.93  ?  281  VAL A CA  1 
ATOM   433  C C   . VAL A 1 58  ? -13.737 -35.683 27.449  1.00 11.31 ?  281  VAL A C   1 
ATOM   434  O O   . VAL A 1 58  ? -14.022 -36.119 26.331  1.00 14.00 ?  281  VAL A O   1 
ATOM   435  C CB  . VAL A 1 58  ? -13.954 -33.215 27.111  1.00 7.93  ?  281  VAL A CB  1 
ATOM   436  C CG1 . VAL A 1 58  ? -14.570 -31.917 27.610  1.00 10.09 ?  281  VAL A CG1 1 
ATOM   437  C CG2 . VAL A 1 58  ? -12.418 -33.056 27.083  1.00 8.30  ?  281  VAL A CG2 1 
ATOM   438  N N   . ASN A 1 59  ? -12.868 -36.317 28.235  1.00 7.20  ?  282  ASN A N   1 
ATOM   439  C CA  . ASN A 1 59  ? -12.205 -37.527 27.793  1.00 9.11  ?  282  ASN A CA  1 
ATOM   440  C C   . ASN A 1 59  ? -12.982 -38.795 28.134  1.00 10.64 ?  282  ASN A C   1 
ATOM   441  O O   . ASN A 1 59  ? -12.591 -39.872 27.686  1.00 15.83 ?  282  ASN A O   1 
ATOM   442  C CB  . ASN A 1 59  ? -10.790 -37.606 28.395  1.00 10.15 ?  282  ASN A CB  1 
ATOM   443  C CG  . ASN A 1 59  ? -9.955  -36.347 28.106  1.00 14.52 ?  282  ASN A CG  1 
ATOM   444  O OD1 . ASN A 1 59  ? -9.295  -35.760 29.042  1.00 15.61 ?  282  ASN A OD1 1 
ATOM   445  N ND2 . ASN A 1 59  ? -9.965  -35.931 26.855  1.00 11.81 ?  282  ASN A ND2 1 
ATOM   446  N N   . ILE A 1 60  ? -14.095 -38.702 28.858  1.00 7.47  ?  283  ILE A N   1 
ATOM   447  C CA  . ILE A 1 60  ? -14.785 -39.895 29.339  1.00 6.67  ?  283  ILE A CA  1 
ATOM   448  C C   . ILE A 1 60  ? -15.543 -40.550 28.172  1.00 9.07  ?  283  ILE A C   1 
ATOM   449  O O   . ILE A 1 60  ? -16.322 -39.887 27.476  1.00 8.87  ?  283  ILE A O   1 
ATOM   450  C CB  . ILE A 1 60  ? -15.752 -39.485 30.462  1.00 6.61  ?  283  ILE A CB  1 
ATOM   451  C CG1 . ILE A 1 60  ? -14.974 -38.896 31.661  1.00 9.78  ?  283  ILE A CG1 1 
ATOM   452  C CG2 . ILE A 1 60  ? -16.618 -40.690 30.896  1.00 9.17  ?  283  ILE A CG2 1 
ATOM   453  C CD1 . ILE A 1 60  ? -15.882 -38.131 32.615  1.00 12.09 ?  283  ILE A CD1 1 
ATOM   454  N N   . CYS A 1 61  ? -15.324 -41.869 27.947  1.00 8.01  ?  284  CYS A N   1 
ATOM   455  C CA  . CYS A 1 61  ? -15.935 -42.651 26.858  1.00 6.36  ?  284  CYS A CA  1 
ATOM   456  C C   . CYS A 1 61  ? -15.487 -42.198 25.452  1.00 7.73  ?  284  CYS A C   1 
ATOM   457  O O   . CYS A 1 61  ? -16.197 -42.486 24.440  1.00 8.66  ?  284  CYS A O   1 
ATOM   458  C CB  . CYS A 1 61  ? -17.486 -42.642 26.961  1.00 7.38  ?  284  CYS A CB  1 
ATOM   459  S SG  . CYS A 1 61  ? -18.149 -43.517 28.431  1.00 9.44  ?  284  CYS A SG  1 
ATOM   460  N N   . THR A 1 62  ? -14.318 -41.544 25.332  1.00 7.75  ?  285  THR A N   1 
ATOM   461  C CA  . THR A 1 62  ? -13.687 -41.310 24.036  1.00 7.09  ?  285  THR A CA  1 
ATOM   462  C C   . THR A 1 62  ? -12.625 -42.376 23.788  1.00 10.23 ?  285  THR A C   1 
ATOM   463  O O   . THR A 1 62  ? -12.085 -42.982 24.722  1.00 11.37 ?  285  THR A O   1 
ATOM   464  C CB  . THR A 1 62  ? -13.023 -39.933 23.947  1.00 11.44 ?  285  THR A CB  1 
ATOM   465  O OG1 . THR A 1 62  ? -11.970 -39.805 24.945  1.00 17.26 ?  285  THR A OG1 1 
ATOM   466  C CG2 . THR A 1 62  ? -14.053 -38.833 24.157  1.00 9.46  ?  285  THR A CG2 1 
ATOM   467  N N   . PHE A 1 63  ? -12.369 -42.626 22.519  1.00 8.43  ?  286  PHE A N   1 
ATOM   468  C CA  . PHE A 1 63  ? -11.275 -43.533 22.139  1.00 8.07  ?  286  PHE A CA  1 
ATOM   469  C C   . PHE A 1 63  ? -10.487 -42.952 20.979  1.00 8.94  ?  286  PHE A C   1 
ATOM   470  O O   . PHE A 1 63  ? -11.050 -42.250 20.134  1.00 8.01  ?  286  PHE A O   1 
ATOM   471  C CB  . PHE A 1 63  ? -11.790 -44.914 21.679  1.00 7.55  ?  286  PHE A CB  1 
ATOM   472  C CG  . PHE A 1 63  ? -12.713 -45.613 22.659  1.00 9.15  ?  286  PHE A CG  1 
ATOM   473  C CD1 . PHE A 1 63  ? -14.101 -45.360 22.632  1.00 10.79 ?  286  PHE A CD1 1 
ATOM   474  C CD2 . PHE A 1 63  ? -12.218 -46.587 23.540  1.00 10.17 ?  286  PHE A CD2 1 
ATOM   475  C CE1 . PHE A 1 63  ? -14.965 -46.014 23.531  1.00 11.00 ?  286  PHE A CE1 1 
ATOM   476  C CE2 . PHE A 1 63  ? -13.107 -47.283 24.402  1.00 10.83 ?  286  PHE A CE2 1 
ATOM   477  C CZ  . PHE A 1 63  ? -14.443 -46.991 24.407  1.00 10.02 ?  286  PHE A CZ  1 
ATOM   478  N N   . ARG A 1 64  ? -9.187  -43.288 20.904  1.00 7.87  ?  287  ARG A N   1 
ATOM   479  C CA  . ARG A 1 64  ? -8.357  -42.831 19.802  1.00 7.02  ?  287  ARG A CA  1 
ATOM   480  C C   . ARG A 1 64  ? -7.378  -43.927 19.408  1.00 7.98  ?  287  ARG A C   1 
ATOM   481  O O   . ARG A 1 64  ? -6.920  -44.670 20.283  1.00 9.06  ?  287  ARG A O   1 
ATOM   482  C CB  . ARG A 1 64  ? -7.502  -41.577 20.198  1.00 11.38 ?  287  ARG A CB  1 
ATOM   483  C CG  . ARG A 1 64  ? -8.252  -40.257 20.525  1.00 14.57 ?  287  ARG A CG  1 
ATOM   484  C CD  . ARG A 1 64  ? -7.228  -39.304 21.322  1.00 13.84 ?  287  ARG A CD  1 
ATOM   485  N NE  . ARG A 1 64  ? -7.767  -37.933 21.388  1.00 16.39 ?  287  ARG A NE  1 
ATOM   486  C CZ  . ARG A 1 64  ? -8.675  -37.582 22.278  1.00 18.49 ?  287  ARG A CZ  1 
ATOM   487  N NH1 . ARG A 1 64  ? -9.141  -38.461 23.160  1.00 21.29 ?  287  ARG A NH1 1 
ATOM   488  N NH2 . ARG A 1 64  ? -9.232  -36.369 22.208  1.00 17.44 ?  287  ARG A NH2 1 
ATOM   489  N N   . GLY A 1 65  ? -7.009  -43.971 18.124  1.00 8.61  ?  288  GLY A N   1 
ATOM   490  C CA  . GLY A 1 65  ? -6.024  -44.965 17.653  1.00 8.59  ?  288  GLY A CA  1 
ATOM   491  C C   . GLY A 1 65  ? -6.090  -45.062 16.134  1.00 9.60  ?  288  GLY A C   1 
ATOM   492  O O   . GLY A 1 65  ? -6.511  -44.120 15.464  1.00 10.50 ?  288  GLY A O   1 
ATOM   493  N N   . ASP A 1 66  ? -5.606  -46.185 15.597  1.00 10.31 ?  289  ASP A N   1 
ATOM   494  C CA  . ASP A 1 66  ? -5.745  -46.469 14.177  1.00 9.53  ?  289  ASP A CA  1 
ATOM   495  C C   . ASP A 1 66  ? -6.773  -47.585 14.020  1.00 10.52 ?  289  ASP A C   1 
ATOM   496  O O   . ASP A 1 66  ? -7.020  -48.338 14.969  1.00 10.58 ?  289  ASP A O   1 
ATOM   497  C CB  . ASP A 1 66  ? -4.393  -46.871 13.534  1.00 11.24 ?  289  ASP A CB  1 
ATOM   498  C CG  . ASP A 1 66  ? -3.872  -48.189 14.070  1.00 14.85 ?  289  ASP A CG  1 
ATOM   499  O OD1 . ASP A 1 66  ? -3.213  -48.207 15.148  1.00 17.40 -1 289  ASP A OD1 1 
ATOM   500  O OD2 . ASP A 1 66  ? -4.155  -49.215 13.439  1.00 18.50 ?  289  ASP A OD2 1 
ATOM   501  N N   . VAL A 1 67  ? -7.410  -47.671 12.830  1.00 9.07  ?  290  VAL A N   1 
ATOM   502  C CA  . VAL A 1 67  ? -8.468  -48.653 12.606  1.00 11.07 ?  290  VAL A CA  1 
ATOM   503  C C   . VAL A 1 67  ? -8.146  -49.559 11.421  1.00 12.90 ?  290  VAL A C   1 
ATOM   504  O O   . VAL A 1 67  ? -7.438  -49.179 10.478  1.00 11.28 ?  290  VAL A O   1 
ATOM   505  C CB  . VAL A 1 67  ? -9.854  -48.003 12.380  1.00 10.11 ?  290  VAL A CB  1 
ATOM   506  C CG1 . VAL A 1 67  ? -10.348 -47.333 13.718  1.00 10.30 ?  290  VAL A CG1 1 
ATOM   507  C CG2 . VAL A 1 67  ? -9.814  -47.006 11.187  1.00 7.76  ?  290  VAL A CG2 1 
ATOM   508  N N   . THR A 1 68  ? -8.658  -50.783 11.510  1.00 13.72 ?  291  THR A N   1 
ATOM   509  C CA  . THR A 1 68  ? -8.529  -51.763 10.436  1.00 13.72 ?  291  THR A CA  1 
ATOM   510  C C   . THR A 1 68  ? -9.911  -52.339 10.166  1.00 13.04 ?  291  THR A C   1 
ATOM   511  O O   . THR A 1 68  ? -10.664 -52.657 11.090  1.00 12.57 ?  291  THR A O   1 
ATOM   512  C CB  . THR A 1 68  ? -7.495  -52.845 10.800  1.00 17.23 ?  291  THR A CB  1 
ATOM   513  O OG1 . THR A 1 68  ? -7.921  -53.565 11.942  1.00 22.82 ?  291  THR A OG1 1 
ATOM   514  C CG2 . THR A 1 68  ? -6.180  -52.271 11.220  1.00 15.82 ?  291  THR A CG2 1 
ATOM   515  N N   . HIS A 1 69  ? -10.238 -52.472 8.893   1.00 14.03 ?  292  HIS A N   1 
ATOM   516  C CA  . HIS A 1 69  ? -11.553 -52.944 8.497   1.00 13.70 ?  292  HIS A CA  1 
ATOM   517  C C   . HIS A 1 69  ? -11.710 -54.427 8.790   1.00 17.01 ?  292  HIS A C   1 
ATOM   518  O O   . HIS A 1 69  ? -10.761 -55.205 8.616   1.00 19.14 ?  292  HIS A O   1 
ATOM   519  C CB  . HIS A 1 69  ? -11.765 -52.699 7.004   1.00 14.02 ?  292  HIS A CB  1 
ATOM   520  C CG  . HIS A 1 69  ? -13.108 -53.137 6.545   1.00 17.05 ?  292  HIS A CG  1 
ATOM   521  N ND1 . HIS A 1 69  ? -13.291 -54.087 5.556   1.00 21.11 ?  292  HIS A ND1 1 
ATOM   522  C CD2 . HIS A 1 69  ? -14.337 -52.814 6.988   1.00 16.65 ?  292  HIS A CD2 1 
ATOM   523  C CE1 . HIS A 1 69  ? -14.584 -54.292 5.391   1.00 21.86 ?  292  HIS A CE1 1 
ATOM   524  N NE2 . HIS A 1 69  ? -15.243 -53.539 6.252   1.00 19.74 ?  292  HIS A NE2 1 
ATOM   525  N N   . ILE A 1 70  ? -12.899 -54.809 9.264   1.00 16.68 ?  293  ILE A N   1 
ATOM   526  C CA  . ILE A 1 70  ? -13.235 -56.210 9.537   1.00 17.85 ?  293  ILE A CA  1 
ATOM   527  C C   . ILE A 1 70  ? -13.948 -56.775 8.299   1.00 17.54 ?  293  ILE A C   1 
ATOM   528  O O   . ILE A 1 70  ? -15.065 -56.363 7.955   1.00 17.77 ?  293  ILE A O   1 
ATOM   529  C CB  . ILE A 1 70  ? -14.079 -56.345 10.813  1.00 17.02 ?  293  ILE A CB  1 
ATOM   530  C CG1 . ILE A 1 70  ? -13.226 -55.921 12.024  1.00 16.58 ?  293  ILE A CG1 1 
ATOM   531  C CG2 . ILE A 1 70  ? -14.562 -57.826 10.999  1.00 20.05 ?  293  ILE A CG2 1 
ATOM   532  C CD1 . ILE A 1 70  ? -13.991 -55.760 13.298  1.00 16.78 ?  293  ILE A CD1 1 
ATOM   533  N N   . THR A 1 71  ? -13.277 -57.685 7.576   1.00 19.82 ?  294  THR A N   1 
ATOM   534  C CA  . THR A 1 71  ? -13.808 -58.077 6.262   1.00 23.53 ?  294  THR A CA  1 
ATOM   535  C C   . THR A 1 71  ? -15.202 -58.680 6.380   1.00 22.94 ?  294  THR A C   1 
ATOM   536  O O   . THR A 1 71  ? -15.514 -59.371 7.353   1.00 23.57 ?  294  THR A O   1 
ATOM   537  C CB  . THR A 1 71  ? -12.878 -59.077 5.580   1.00 29.59 ?  294  THR A CB  1 
ATOM   538  O OG1 . THR A 1 71  ? -11.549 -58.546 5.582   1.00 33.05 ?  294  THR A OG1 1 
ATOM   539  C CG2 . THR A 1 71  ? -13.322 -59.288 4.139   1.00 30.43 ?  294  THR A CG2 1 
ATOM   540  N N   . GLY A 1 72  ? -16.061 -58.373 5.406   1.00 22.83 ?  295  GLY A N   1 
ATOM   541  C CA  . GLY A 1 72  ? -17.415 -58.894 5.441   1.00 21.40 ?  295  GLY A CA  1 
ATOM   542  C C   . GLY A 1 72  ? -18.393 -58.090 6.277   1.00 26.18 ?  295  GLY A C   1 
ATOM   543  O O   . GLY A 1 72  ? -19.538 -58.526 6.461   1.00 27.92 ?  295  GLY A O   1 
ATOM   544  N N   . SER A 1 73  ? -17.975 -56.934 6.800   1.00 20.48 ?  296  SER A N   1 
ATOM   545  C CA  . SER A 1 73  ? -18.808 -56.138 7.684   1.00 17.97 ?  296  SER A CA  1 
ATOM   546  C C   . SER A 1 73  ? -18.612 -54.655 7.367   1.00 17.70 ?  296  SER A C   1 
ATOM   547  O O   . SER A 1 73  ? -17.818 -54.281 6.506   1.00 18.52 ?  296  SER A O   1 
ATOM   548  C CB  . SER A 1 73  ? -18.477 -56.378 9.160   1.00 19.09 ?  296  SER A CB  1 
ATOM   549  O OG  . SER A 1 73  ? -17.237 -55.750 9.455   1.00 17.01 ?  296  SER A OG  1 
ATOM   550  N N   . ARG A 1 74  ? -19.393 -53.829 8.059   1.00 16.51 ?  297  ARG A N   1 
ATOM   551  C CA  . ARG A 1 74  ? -19.155 -52.385 8.153   1.00 15.08 ?  297  ARG A CA  1 
ATOM   552  C C   . ARG A 1 74  ? -18.495 -52.012 9.479   1.00 14.04 ?  297  ARG A C   1 
ATOM   553  O O   . ARG A 1 74  ? -18.726 -50.918 10.019  1.00 12.64 ?  297  ARG A O   1 
ATOM   554  C CB  . ARG A 1 74  ? -20.474 -51.632 7.940   1.00 16.62 ?  297  ARG A CB  1 
ATOM   555  C CG  . ARG A 1 74  ? -21.195 -52.147 6.666   1.00 23.89 ?  297  ARG A CG  1 
ATOM   556  C CD  . ARG A 1 74  ? -22.242 -51.218 6.031   1.00 27.97 ?  297  ARG A CD  1 
ATOM   557  N NE  . ARG A 1 74  ? -23.255 -50.779 6.980   1.00 32.69 ?  297  ARG A NE  1 
ATOM   558  C CZ  . ARG A 1 74  ? -24.272 -49.973 6.678   1.00 40.26 ?  297  ARG A CZ  1 
ATOM   559  N NH1 . ARG A 1 74  ? -24.446 -49.508 5.446   1.00 45.67 ?  297  ARG A NH1 1 
ATOM   560  N NH2 . ARG A 1 74  ? -25.113 -49.592 7.646   1.00 37.61 ?  297  ARG A NH2 1 
ATOM   561  N N   . ASN A 1 75  ? -17.686 -52.901 10.024  1.00 13.67 ?  298  ASN A N   1 
ATOM   562  C CA  . ASN A 1 75  ? -17.126 -52.712 11.353  1.00 14.69 ?  298  ASN A CA  1 
ATOM   563  C C   . ASN A 1 75  ? -15.618 -52.575 11.273  1.00 14.96 ?  298  ASN A C   1 
ATOM   564  O O   . ASN A 1 75  ? -14.979 -53.008 10.311  1.00 14.27 ?  298  ASN A O   1 
ATOM   565  C CB  . ASN A 1 75  ? -17.489 -53.869 12.243  1.00 13.23 ?  298  ASN A CB  1 
ATOM   566  C CG  . ASN A 1 75  ? -18.969 -54.054 12.321  1.00 16.25 ?  298  ASN A CG  1 
ATOM   567  O OD1 . ASN A 1 75  ? -19.734 -53.147 11.973  1.00 18.49 ?  298  ASN A OD1 1 
ATOM   568  N ND2 . ASN A 1 75  ? -19.377 -55.210 12.726  1.00 19.45 ?  298  ASN A ND2 1 
ATOM   569  N N   . TYR A 1 76  ? -15.051 -51.946 12.299  1.00 12.64 ?  299  TYR A N   1 
ATOM   570  C CA  . TYR A 1 76  ? -13.628 -51.640 12.329  1.00 12.95 ?  299  TYR A CA  1 
ATOM   571  C C   . TYR A 1 76  ? -13.067 -51.975 13.703  1.00 11.23 ?  299  TYR A C   1 
ATOM   572  O O   . TYR A 1 76  ? -13.696 -51.681 14.720  1.00 12.05 ?  299  TYR A O   1 
ATOM   573  C CB  . TYR A 1 76  ? -13.332 -50.130 12.029  1.00 9.97  ?  299  TYR A CB  1 
ATOM   574  C CG  . TYR A 1 76  ? -13.574 -49.767 10.589  1.00 9.14  ?  299  TYR A CG  1 
ATOM   575  C CD1 . TYR A 1 76  ? -14.859 -49.512 10.150  1.00 11.24 ?  299  TYR A CD1 1 
ATOM   576  C CD2 . TYR A 1 76  ? -12.529 -49.737 9.675   1.00 11.45 ?  299  TYR A CD2 1 
ATOM   577  C CE1 . TYR A 1 76  ? -15.106 -49.241 8.840   1.00 12.54 ?  299  TYR A CE1 1 
ATOM   578  C CE2 . TYR A 1 76  ? -12.769 -49.448 8.322   1.00 11.55 ?  299  TYR A CE2 1 
ATOM   579  C CZ  . TYR A 1 76  ? -14.068 -49.205 7.941   1.00 12.98 ?  299  TYR A CZ  1 
ATOM   580  O OH  . TYR A 1 76  ? -14.364 -48.896 6.622   1.00 15.02 ?  299  TYR A OH  1 
ATOM   581  N N   . THR A 1 77  ? -11.872 -52.585 13.729  1.00 10.14 ?  300  THR A N   1 
ATOM   582  C CA  . THR A 1 77  ? -11.108 -52.724 14.967  1.00 9.78  ?  300  THR A CA  1 
ATOM   583  C C   . THR A 1 77  ? -10.298 -51.467 15.172  1.00 9.92  ?  300  THR A C   1 
ATOM   584  O O   . THR A 1 77  ? -9.627  -51.030 14.237  1.00 12.00 ?  300  THR A O   1 
ATOM   585  C CB  . THR A 1 77  ? -10.152 -53.907 14.868  1.00 12.41 ?  300  THR A CB  1 
ATOM   586  O OG1 . THR A 1 77  ? -10.957 -55.093 14.793  1.00 14.54 ?  300  THR A OG1 1 
ATOM   587  C CG2 . THR A 1 77  ? -9.195  -53.932 16.080  1.00 14.30 ?  300  THR A CG2 1 
ATOM   588  N N   . MET A 1 78  ? -10.401 -50.851 16.353  1.00 9.72  ?  301  MET A N   1 
ATOM   589  C CA  . MET A 1 78  ? -9.468  -49.807 16.737  1.00 9.07  ?  301  MET A CA  1 
ATOM   590  C C   . MET A 1 78  ? -8.355  -50.356 17.601  1.00 10.45 ?  301  MET A C   1 
ATOM   591  O O   . MET A 1 78  ? -8.626  -50.946 18.646  1.00 10.09 ?  301  MET A O   1 
ATOM   592  C CB  . MET A 1 78  ? -10.138 -48.702 17.545  1.00 8.82  ?  301  MET A CB  1 
ATOM   593  C CG  . MET A 1 78  ? -9.187  -47.465 17.741  1.00 7.96  ?  301  MET A CG  1 
ATOM   594  S SD  . MET A 1 78  ? -10.039 -46.084 18.596  1.00 8.33  ?  301  MET A SD  1 
ATOM   595  C CE  . MET A 1 78  ? -10.785 -45.248 17.187  1.00 10.76 ?  301  MET A CE  1 
ATOM   596  N N   . ASN A 1 79  ? -7.116  -50.081 17.208  1.00 9.84  ?  302  ASN A N   1 
ATOM   597  C CA  . ASN A 1 79  ? -5.954  -50.379 18.025  1.00 10.87 ?  302  ASN A CA  1 
ATOM   598  C C   . ASN A 1 79  ? -5.684  -49.136 18.846  1.00 9.32  ?  302  ASN A C   1 
ATOM   599  O O   . ASN A 1 79  ? -5.307  -48.111 18.278  1.00 9.85  ?  302  ASN A O   1 
ATOM   600  C CB  . ASN A 1 79  ? -4.774  -50.717 17.116  1.00 12.43 ?  302  ASN A CB  1 
ATOM   601  C CG  . ASN A 1 79  ? -5.110  -51.892 16.230  1.00 19.09 ?  302  ASN A CG  1 
ATOM   602  O OD1 . ASN A 1 79  ? -5.503  -52.942 16.737  1.00 21.33 ?  302  ASN A OD1 1 
ATOM   603  N ND2 . ASN A 1 79  ? -5.112  -51.681 14.916  1.00 22.86 ?  302  ASN A ND2 1 
ATOM   604  N N   . LEU A 1 80  ? -5.962  -49.185 20.164  1.00 7.97  ?  303  LEU A N   1 
ATOM   605  C CA  . LEU A 1 80  ? -5.961  -47.945 20.945  1.00 9.74  ?  303  LEU A CA  1 
ATOM   606  C C   . LEU A 1 80  ? -4.563  -47.349 21.091  1.00 12.68 ?  303  LEU A C   1 
ATOM   607  O O   . LEU A 1 80  ? -3.564  -48.076 21.266  1.00 12.26 ?  303  LEU A O   1 
ATOM   608  C CB  . LEU A 1 80  ? -6.532  -48.190 22.355  1.00 9.01  ?  303  LEU A CB  1 
ATOM   609  C CG  . LEU A 1 80  ? -7.981  -48.688 22.404  1.00 8.20  ?  303  LEU A CG  1 
ATOM   610  C CD1 . LEU A 1 80  ? -8.448  -48.884 23.855  1.00 8.61  ?  303  LEU A CD1 1 
ATOM   611  C CD2 . LEU A 1 80  ? -8.978  -47.747 21.691  1.00 10.52 ?  303  LEU A CD2 1 
ATOM   612  N N   . ALA A 1 81  ? -4.507  -46.013 20.999  1.00 9.30  ?  304  ALA A N   1 
ATOM   613  C CA  . ALA A 1 81  ? -3.389  -45.189 21.417  1.00 10.20 ?  304  ALA A CA  1 
ATOM   614  C C   . ALA A 1 81  ? -3.726  -44.557 22.772  1.00 12.96 ?  304  ALA A C   1 
ATOM   615  O O   . ALA A 1 81  ? -4.894  -44.544 23.205  1.00 11.67 ?  304  ALA A O   1 
ATOM   616  C CB  . ALA A 1 81  ? -3.111  -44.056 20.402  1.00 11.63 ?  304  ALA A CB  1 
ATOM   617  N N   . SER A 1 82  ? -2.683  -43.994 23.440  1.00 12.15 ?  305  SER A N   1 
ATOM   618  C CA  . SER A 1 82  ? -2.932  -43.035 24.508  1.00 13.81 ?  305  SER A CA  1 
ATOM   619  C C   . SER A 1 82  ? -3.658  -41.782 23.975  1.00 14.09 ?  305  SER A C   1 
ATOM   620  O O   . SER A 1 82  ? -3.682  -41.505 22.772  1.00 14.37 ?  305  SER A O   1 
ATOM   621  C CB  . SER A 1 82  ? -1.610  -42.583 25.138  1.00 15.97 ?  305  SER A CB  1 
ATOM   622  O OG  . SER A 1 82  ? -0.943  -43.715 25.682  1.00 22.34 ?  305  SER A OG  1 
ATOM   623  N N   . GLN A 1 83  ? -4.231  -41.024 24.912  1.00 15.37 ?  306  GLN A N   1 
ATOM   624  C CA  . GLN A 1 83  ? -4.945  -39.780 24.586  1.00 16.65 ?  306  GLN A CA  1 
ATOM   625  C C   . GLN A 1 83  ? -4.067  -38.800 23.842  1.00 17.07 ?  306  GLN A C   1 
ATOM   626  O O   . GLN A 1 83  ? -4.573  -38.032 22.998  1.00 16.34 ?  306  GLN A O   1 
ATOM   627  C CB  . GLN A 1 83  ? -5.487  -39.110 25.862  1.00 20.08 ?  306  GLN A CB  1 
ATOM   628  C CG  . GLN A 1 83  ? -5.978  -37.613 25.638  1.00 21.76 ?  306  GLN A CG  1 
ATOM   629  C CD  . GLN A 1 83  ? -5.776  -36.713 26.895  1.00 26.49 ?  306  GLN A CD  1 
ATOM   630  O OE1 . GLN A 1 83  ? -6.552  -36.930 27.836  1.00 21.82 ?  306  GLN A OE1 1 
ATOM   631  N NE2 . GLN A 1 83  ? -4.768  -35.694 26.917  1.00 22.54 ?  306  GLN A NE2 1 
ATOM   632  N N   . ASN A 1 84  ? -2.757  -38.781 24.150  1.00 14.98 ?  307  ASN A N   1 
ATOM   633  C CA  . ASN A 1 84  ? -1.834  -37.891 23.467  1.00 16.74 ?  307  ASN A CA  1 
ATOM   634  C C   . ASN A 1 84  ? -1.186  -38.523 22.229  1.00 16.31 ?  307  ASN A C   1 
ATOM   635  O O   . ASN A 1 84  ? -0.221  -37.960 21.686  1.00 15.97 ?  307  ASN A O   1 
ATOM   636  C CB  . ASN A 1 84  ? -0.759  -37.408 24.458  1.00 16.70 ?  307  ASN A CB  1 
ATOM   637  C CG  . ASN A 1 84  ? 0.118   -38.556 24.967  1.00 19.20 ?  307  ASN A CG  1 
ATOM   638  O OD1 . ASN A 1 84  ? 0.118   -39.660 24.366  1.00 17.39 ?  307  ASN A OD1 1 
ATOM   639  N ND2 . ASN A 1 84  ? 0.870   -38.321 26.083  1.00 16.64 ?  307  ASN A ND2 1 
ATOM   640  N N   . TRP A 1 85  ? -1.686  -39.681 21.767  1.00 14.05 ?  308  TRP A N   1 
ATOM   641  C CA  . TRP A 1 85  ? -1.301  -40.433 20.568  1.00 14.06 ?  308  TRP A CA  1 
ATOM   642  C C   . TRP A 1 85  ? -0.011  -41.229 20.770  1.00 15.86 ?  308  TRP A C   1 
ATOM   643  O O   . TRP A 1 85  ? 0.408   -41.950 19.816  1.00 17.36 ?  308  TRP A O   1 
ATOM   644  C CB  . TRP A 1 85  ? -1.190  -39.560 19.312  1.00 14.91 ?  308  TRP A CB  1 
ATOM   645  C CG  . TRP A 1 85  ? -2.525  -38.932 18.958  1.00 15.69 ?  308  TRP A CG  1 
ATOM   646  C CD1 . TRP A 1 85  ? -2.915  -37.660 19.236  1.00 16.80 ?  308  TRP A CD1 1 
ATOM   647  C CD2 . TRP A 1 85  ? -3.645  -39.561 18.296  1.00 15.91 ?  308  TRP A CD2 1 
ATOM   648  N NE1 . TRP A 1 85  ? -4.206  -37.443 18.785  1.00 18.32 ?  308  TRP A NE1 1 
ATOM   649  C CE2 . TRP A 1 85  ? -4.673  -38.603 18.216  1.00 16.14 ?  308  TRP A CE2 1 
ATOM   650  C CE3 . TRP A 1 85  ? -3.879  -40.858 17.790  1.00 15.16 ?  308  TRP A CE3 1 
ATOM   651  C CZ2 . TRP A 1 85  ? -5.905  -38.878 17.615  1.00 13.85 ?  308  TRP A CZ2 1 
ATOM   652  C CZ3 . TRP A 1 85  ? -5.137  -41.132 17.212  1.00 13.12 ?  308  TRP A CZ3 1 
ATOM   653  C CH2 . TRP A 1 85  ? -6.107  -40.144 17.110  1.00 13.30 ?  308  TRP A CH2 1 
ATOM   654  N N   . ASN A 1 86  ? 0.575   -41.210 21.957  1.00 17.03 ?  309  ASN A N   1 
ATOM   655  C CA  . ASN A 1 86  ? 1.678   -42.124 22.234  1.00 17.02 ?  309  ASN A CA  1 
ATOM   656  C C   . ASN A 1 86  ? 1.154   -43.554 22.268  1.00 17.56 ?  309  ASN A C   1 
ATOM   657  O O   . ASN A 1 86  ? -0.057  -43.806 22.276  1.00 14.98 ?  309  ASN A O   1 
ATOM   658  C CB  . ASN A 1 86  ? 2.350   -41.824 23.575  1.00 18.52 ?  309  ASN A CB  1 
ATOM   659  C CG  . ASN A 1 86  ? 3.179   -40.589 23.526  1.00 21.55 ?  309  ASN A CG  1 
ATOM   660  O OD1 . ASN A 1 86  ? 3.475   -40.064 22.448  1.00 25.22 ?  309  ASN A OD1 1 
ATOM   661  N ND2 . ASN A 1 86  ? 3.566   -40.112 24.681  1.00 25.10 ?  309  ASN A ND2 1 
ATOM   662  N N   . ASP A 1 87  ? 2.071   -44.512 22.318  1.00 18.43 ?  310  ASP A N   1 
ATOM   663  C CA  . ASP A 1 87  ? 1.630   -45.902 22.409  1.00 16.67 ?  310  ASP A CA  1 
ATOM   664  C C   . ASP A 1 87  ? 0.852   -46.126 23.690  1.00 17.48 ?  310  ASP A C   1 
ATOM   665  O O   . ASP A 1 87  ? 1.209   -45.597 24.749  1.00 18.94 ?  310  ASP A O   1 
ATOM   666  C CB  . ASP A 1 87  ? 2.838   -46.858 22.403  1.00 17.15 ?  310  ASP A CB  1 
ATOM   667  C CG  . ASP A 1 87  ? 3.541   -46.903 21.074  1.00 23.04 ?  310  ASP A CG  1 
ATOM   668  O OD1 . ASP A 1 87  ? 3.016   -46.391 20.072  1.00 20.24 ?  310  ASP A OD1 1 
ATOM   669  O OD2 . ASP A 1 87  ? 4.672   -47.454 21.049  1.00 24.03 -1 310  ASP A OD2 1 
ATOM   670  N N   . TYR A 1 88  ? -0.191  -46.967 23.607  1.00 16.01 ?  311  TYR A N   1 
ATOM   671  C CA  . TYR A 1 88  ? -0.876  -47.421 24.806  1.00 17.59 ?  311  TYR A CA  1 
ATOM   672  C C   . TYR A 1 88  ? 0.029   -48.389 25.561  1.00 18.41 ?  311  TYR A C   1 
ATOM   673  O O   . TYR A 1 88  ? 0.645   -49.271 24.953  1.00 21.10 ?  311  TYR A O   1 
ATOM   674  C CB  . TYR A 1 88  ? -2.180  -48.127 24.404  1.00 17.50 ?  311  TYR A CB  1 
ATOM   675  C CG  . TYR A 1 88  ? -2.852  -48.899 25.535  1.00 15.62 ?  311  TYR A CG  1 
ATOM   676  C CD1 . TYR A 1 88  ? -3.205  -48.267 26.719  1.00 16.45 ?  311  TYR A CD1 1 
ATOM   677  C CD2 . TYR A 1 88  ? -3.121  -50.256 25.393  1.00 17.84 ?  311  TYR A CD2 1 
ATOM   678  C CE1 . TYR A 1 88  ? -3.781  -48.961 27.774  1.00 12.32 ?  311  TYR A CE1 1 
ATOM   679  C CE2 . TYR A 1 88  ? -3.724  -50.965 26.418  1.00 15.63 ?  311  TYR A CE2 1 
ATOM   680  C CZ  . TYR A 1 88  ? -4.060  -50.323 27.597  1.00 13.64 ?  311  TYR A CZ  1 
ATOM   681  O OH  . TYR A 1 88  ? -4.622  -51.050 28.588  1.00 14.67 ?  311  TYR A OH  1 
ATOM   682  N N   . ASP A 1 89  ? 0.082   -48.242 26.897  1.00 19.47 ?  312  ASP A N   1 
ATOM   683  C CA  . ASP A 1 89  ? 0.837   -49.147 27.759  1.00 22.22 ?  312  ASP A CA  1 
ATOM   684  C C   . ASP A 1 89  ? -0.100  -50.093 28.520  1.00 20.07 ?  312  ASP A C   1 
ATOM   685  O O   . ASP A 1 89  ? -0.690  -49.684 29.530  1.00 23.55 ?  312  ASP A O   1 
ATOM   686  C CB  . ASP A 1 89  ? 1.675   -48.329 28.740  1.00 23.36 ?  312  ASP A CB  1 
ATOM   687  C CG  . ASP A 1 89  ? 2.451   -49.217 29.705  1.00 25.81 ?  312  ASP A CG  1 
ATOM   688  O OD1 . ASP A 1 89  ? 2.433   -50.464 29.536  1.00 24.16 ?  312  ASP A OD1 1 
ATOM   689  O OD2 . ASP A 1 89  ? 3.065   -48.649 30.620  1.00 34.71 -1 312  ASP A OD2 1 
ATOM   690  N N   . PRO A 1 90  ? -0.251  -51.355 28.118  1.00 21.35 ?  313  PRO A N   1 
ATOM   691  C CA  . PRO A 1 90  ? -1.179  -52.255 28.808  1.00 20.59 ?  313  PRO A CA  1 
ATOM   692  C C   . PRO A 1 90  ? -0.684  -52.756 30.166  1.00 26.39 ?  313  PRO A C   1 
ATOM   693  O O   . PRO A 1 90  ? -1.442  -53.455 30.857  1.00 24.61 ?  313  PRO A O   1 
ATOM   694  C CB  . PRO A 1 90  ? -1.319  -53.409 27.818  1.00 25.18 ?  313  PRO A CB  1 
ATOM   695  C CG  . PRO A 1 90  ? 0.016   -53.448 27.146  1.00 27.20 ?  313  PRO A CG  1 
ATOM   696  C CD  . PRO A 1 90  ? 0.373   -52.015 26.959  1.00 22.97 ?  313  PRO A CD  1 
ATOM   697  N N   . THR A 1 91  ? 0.535   -52.376 30.593  1.00 24.61 ?  314  THR A N   1 
ATOM   698  C CA  . THR A 1 91  ? 1.092   -52.903 31.841  1.00 26.27 ?  314  THR A CA  1 
ATOM   699  C C   . THR A 1 91  ? 0.801   -52.026 33.054  1.00 25.40 ?  314  THR A C   1 
ATOM   700  O O   . THR A 1 91  ? 1.116   -52.439 34.183  1.00 24.69 ?  314  THR A O   1 
ATOM   701  C CB  . THR A 1 91  ? 2.626   -53.083 31.762  1.00 23.43 ?  314  THR A CB  1 
ATOM   702  O OG1 . THR A 1 91  ? 3.261   -51.812 31.618  1.00 27.38 ?  314  THR A OG1 1 
ATOM   703  C CG2 . THR A 1 91  ? 2.983   -53.924 30.586  1.00 26.85 ?  314  THR A CG2 1 
ATOM   704  N N   . GLU A 1 92  ? 0.233   -50.829 32.881  1.00 23.90 ?  315  GLU A N   1 
ATOM   705  C CA  . GLU A 1 92  ? -0.074  -50.012 34.048  1.00 21.87 ?  315  GLU A CA  1 
ATOM   706  C C   . GLU A 1 92  ? -1.123  -50.684 34.931  1.00 18.51 ?  315  GLU A C   1 
ATOM   707  O O   . GLU A 1 92  ? -1.973  -51.448 34.457  1.00 17.85 ?  315  GLU A O   1 
ATOM   708  C CB  . GLU A 1 92  ? -0.558  -48.613 33.671  1.00 25.80 ?  315  GLU A CB  1 
ATOM   709  C CG  . GLU A 1 92  ? 0.555   -47.731 33.178  1.00 36.85 ?  315  GLU A CG  1 
ATOM   710  C CD  . GLU A 1 92  ? 0.055   -46.353 32.862  1.00 44.71 ?  315  GLU A CD  1 
ATOM   711  O OE1 . GLU A 1 92  ? -1.069  -46.246 32.350  1.00 33.27 ?  315  GLU A OE1 1 
ATOM   712  O OE2 . GLU A 1 92  ? 0.774   -45.376 33.172  1.00 70.84 -1 315  GLU A OE2 1 
ATOM   713  N N   . GLU A 1 93  ? -1.054  -50.386 36.231  1.00 19.57 ?  316  GLU A N   1 
ATOM   714  C CA  . GLU A 1 93  ? -1.903  -51.052 37.225  1.00 19.84 ?  316  GLU A CA  1 
ATOM   715  C C   . GLU A 1 93  ? -3.248  -50.344 37.358  1.00 17.37 ?  316  GLU A C   1 
ATOM   716  O O   . GLU A 1 93  ? -3.601  -49.778 38.405  1.00 16.06 ?  316  GLU A O   1 
ATOM   717  C CB  . GLU A 1 93  ? -1.197  -51.139 38.579  1.00 18.71 ?  316  GLU A CB  1 
ATOM   718  C CG  . GLU A 1 93  ? -0.014  -52.097 38.493  1.00 22.93 ?  316  GLU A CG  1 
ATOM   719  C CD  . GLU A 1 93  ? 0.687   -52.327 39.834  1.00 31.46 ?  316  GLU A CD  1 
ATOM   720  O OE1 . GLU A 1 93  ? 0.433   -51.588 40.805  1.00 35.93 ?  316  GLU A OE1 1 
ATOM   721  O OE2 . GLU A 1 93  ? 1.468   -53.281 39.895  1.00 40.09 -1 316  GLU A OE2 1 
ATOM   722  N N   . ILE A 1 94  ? -3.983  -50.384 36.250  1.00 13.97 ?  317  ILE A N   1 
ATOM   723  C CA  . ILE A 1 94  ? -5.342  -49.834 36.148  1.00 13.68 ?  317  ILE A CA  1 
ATOM   724  C C   . ILE A 1 94  ? -6.234  -50.841 35.428  1.00 10.43 ?  317  ILE A C   1 
ATOM   725  O O   . ILE A 1 94  ? -5.752  -51.747 34.733  1.00 13.77 ?  317  ILE A O   1 
ATOM   726  C CB  . ILE A 1 94  ? -5.334  -48.494 35.389  1.00 11.58 ?  317  ILE A CB  1 
ATOM   727  C CG1 . ILE A 1 94  ? -4.738  -48.703 34.007  1.00 12.21 ?  317  ILE A CG1 1 
ATOM   728  C CG2 . ILE A 1 94  ? -4.537  -47.421 36.198  1.00 15.47 ?  317  ILE A CG2 1 
ATOM   729  C CD1 . ILE A 1 94  ? -4.645  -47.421 33.136  1.00 15.30 ?  317  ILE A CD1 1 
ATOM   730  N N   . PRO A 1 95  ? -7.557  -50.713 35.581  1.00 10.60 ?  318  PRO A N   1 
ATOM   731  C CA  . PRO A 1 95  ? -8.455  -51.711 34.964  1.00 9.80  ?  318  PRO A CA  1 
ATOM   732  C C   . PRO A 1 95  ? -8.466  -51.661 33.442  1.00 9.75  ?  318  PRO A C   1 
ATOM   733  O O   . PRO A 1 95  ? -8.809  -52.669 32.797  1.00 10.62 ?  318  PRO A O   1 
ATOM   734  C CB  . PRO A 1 95  ? -9.844  -51.337 35.542  1.00 10.20 ?  318  PRO A CB  1 
ATOM   735  C CG  . PRO A 1 95  ? -9.546  -50.568 36.763  1.00 12.14 ?  318  PRO A CG  1 
ATOM   736  C CD  . PRO A 1 95  ? -8.277  -49.814 36.490  1.00 12.24 ?  318  PRO A CD  1 
ATOM   737  N N   . ALA A 1 96  ? -8.197  -50.472 32.856  1.00 11.16 ?  319  ALA A N   1 
ATOM   738  C CA  . ALA A 1 96  ? -8.417  -50.155 31.443  1.00 8.95  ?  319  ALA A CA  1 
ATOM   739  C C   . ALA A 1 96  ? -7.894  -48.726 31.279  1.00 8.80  ?  319  ALA A C   1 
ATOM   740  O O   . ALA A 1 96  ? -7.670  -48.054 32.284  1.00 9.89  ?  319  ALA A O   1 
ATOM   741  C CB  . ALA A 1 96  ? -9.915  -50.251 31.085  1.00 9.79  ?  319  ALA A CB  1 
ATOM   742  N N   . PRO A 1 97  ? -7.719  -48.234 30.062  1.00 9.43  ?  320  PRO A N   1 
ATOM   743  C CA  . PRO A 1 97  ? -7.299  -46.835 29.884  1.00 9.27  ?  320  PRO A CA  1 
ATOM   744  C C   . PRO A 1 97  ? -8.197  -45.925 30.700  1.00 8.31  ?  320  PRO A C   1 
ATOM   745  O O   . PRO A 1 97  ? -9.422  -46.158 30.825  1.00 10.23 ?  320  PRO A O   1 
ATOM   746  C CB  . PRO A 1 97  ? -7.473  -46.595 28.376  1.00 9.39  ?  320  PRO A CB  1 
ATOM   747  C CG  . PRO A 1 97  ? -7.254  -47.999 27.787  1.00 11.81 ?  320  PRO A CG  1 
ATOM   748  C CD  . PRO A 1 97  ? -7.959  -48.916 28.788  1.00 10.47 ?  320  PRO A CD  1 
ATOM   749  N N   . LEU A 1 98  ? -7.595  -44.862 31.259  1.00 9.24  ?  321  LEU A N   1 
ATOM   750  C CA  . LEU A 1 98  ? -8.404  -43.921 32.046  1.00 8.20  ?  321  LEU A CA  1 
ATOM   751  C C   . LEU A 1 98  ? -9.523  -43.347 31.149  1.00 8.26  ?  321  LEU A C   1 
ATOM   752  O O   . LEU A 1 98  ? -9.292  -42.968 29.986  1.00 9.25  ?  321  LEU A O   1 
ATOM   753  C CB  . LEU A 1 98  ? -7.529  -42.812 32.625  1.00 10.33 ?  321  LEU A CB  1 
ATOM   754  C CG  . LEU A 1 98  ? -6.336  -43.334 33.457  1.00 11.24 ?  321  LEU A CG  1 
ATOM   755  C CD1 . LEU A 1 98  ? -5.596  -42.150 34.044  1.00 13.05 ?  321  LEU A CD1 1 
ATOM   756  C CD2 . LEU A 1 98  ? -6.830  -44.296 34.546  1.00 11.26 ?  321  LEU A CD2 1 
ATOM   757  N N   . GLY A 1 99  ? -10.752 -43.326 31.684  1.00 8.11  ?  322  GLY A N   1 
ATOM   758  C CA  . GLY A 1 99  ? -11.928 -42.779 30.983  1.00 8.52  ?  322  GLY A CA  1 
ATOM   759  C C   . GLY A 1 99  ? -12.712 -43.817 30.188  1.00 8.84  ?  322  GLY A C   1 
ATOM   760  O O   . GLY A 1 99  ? -13.800 -43.512 29.682  1.00 8.69  ?  322  GLY A O   1 
ATOM   761  N N   . THR A 1 100 ? -12.243 -45.078 30.164  1.00 7.65  ?  323  THR A N   1 
ATOM   762  C CA  . THR A 1 100 ? -12.968 -46.141 29.485  1.00 8.63  ?  323  THR A CA  1 
ATOM   763  C C   . THR A 1 100 ? -14.385 -46.258 30.051  1.00 7.86  ?  323  THR A C   1 
ATOM   764  O O   . THR A 1 100 ? -14.570 -46.099 31.260  1.00 8.25  ?  323  THR A O   1 
ATOM   765  C CB  . THR A 1 100 ? -12.244 -47.476 29.701  1.00 7.92  ?  323  THR A CB  1 
ATOM   766  O OG1 . THR A 1 100 ? -10.940 -47.420 29.127  1.00 9.90  ?  323  THR A OG1 1 
ATOM   767  C CG2 . THR A 1 100 ? -13.017 -48.722 29.134  1.00 10.04 ?  323  THR A CG2 1 
ATOM   768  N N   . PRO A 1 101 ? -15.397 -46.573 29.220  1.00 8.19  ?  324  PRO A N   1 
ATOM   769  C CA  . PRO A 1 101 ? -16.742 -46.776 29.774  1.00 7.87  ?  324  PRO A CA  1 
ATOM   770  C C   . PRO A 1 101 ? -16.727 -47.808 30.897  1.00 8.79  ?  324  PRO A C   1 
ATOM   771  O O   . PRO A 1 101 ? -16.027 -48.819 30.809  1.00 9.12  ?  324  PRO A O   1 
ATOM   772  C CB  . PRO A 1 101 ? -17.557 -47.278 28.570  1.00 7.65  ?  324  PRO A CB  1 
ATOM   773  C CG  . PRO A 1 101 ? -16.774 -46.779 27.346  1.00 10.31 ?  324  PRO A CG  1 
ATOM   774  C CD  . PRO A 1 101 ? -15.339 -46.732 27.750  1.00 7.85  ?  324  PRO A CD  1 
ATOM   775  N N   . ASP A 1 102 ? -17.519 -47.562 31.944  1.00 8.46  ?  325  ASP A N   1 
ATOM   776  C CA  . ASP A 1 102 ? -17.572 -48.459 33.101  1.00 8.92  ?  325  ASP A CA  1 
ATOM   777  C C   . ASP A 1 102 ? -18.948 -49.102 33.264  1.00 10.59 ?  325  ASP A C   1 
ATOM   778  O O   . ASP A 1 102 ? -19.350 -49.469 34.377  1.00 10.69 ?  325  ASP A O   1 
ATOM   779  C CB  . ASP A 1 102 ? -17.122 -47.748 34.399  1.00 9.46  ?  325  ASP A CB  1 
ATOM   780  C CG  . ASP A 1 102 ? -18.103 -46.663 34.862  1.00 9.85  ?  325  ASP A CG  1 
ATOM   781  O OD1 . ASP A 1 102 ? -19.109 -46.412 34.133  1.00 9.34  ?  325  ASP A OD1 1 
ATOM   782  O OD2 . ASP A 1 102 ? -17.840 -46.102 35.946  1.00 7.96  -1 325  ASP A OD2 1 
ATOM   783  N N   . PHE A 1 103 ? -19.679 -49.269 32.167  1.00 8.48  ?  326  PHE A N   1 
ATOM   784  C CA  . PHE A 1 103 ? -20.953 -49.972 32.227  1.00 8.92  ?  326  PHE A CA  1 
ATOM   785  C C   . PHE A 1 103 ? -21.154 -50.774 30.943  1.00 9.93  ?  326  PHE A C   1 
ATOM   786  O O   . PHE A 1 103 ? -20.565 -50.452 29.910  1.00 9.52  ?  326  PHE A O   1 
ATOM   787  C CB  . PHE A 1 103 ? -22.128 -49.009 32.477  1.00 9.60  ?  326  PHE A CB  1 
ATOM   788  C CG  . PHE A 1 103 ? -22.278 -47.928 31.410  1.00 8.34  ?  326  PHE A CG  1 
ATOM   789  C CD1 . PHE A 1 103 ? -23.054 -48.158 30.278  1.00 10.40 ?  326  PHE A CD1 1 
ATOM   790  C CD2 . PHE A 1 103 ? -21.638 -46.709 31.560  1.00 8.83  ?  326  PHE A CD2 1 
ATOM   791  C CE1 . PHE A 1 103 ? -23.199 -47.176 29.266  1.00 10.49 ?  326  PHE A CE1 1 
ATOM   792  C CE2 . PHE A 1 103 ? -21.807 -45.673 30.571  1.00 10.24 ?  326  PHE A CE2 1 
ATOM   793  C CZ  . PHE A 1 103 ? -22.587 -45.933 29.423  1.00 9.40  ?  326  PHE A CZ  1 
ATOM   794  N N   . VAL A 1 104 ? -21.999 -51.821 31.018  1.00 9.33  ?  327  VAL A N   1 
ATOM   795  C CA  . VAL A 1 104 ? -22.382 -52.607 29.836  1.00 7.89  ?  327  VAL A CA  1 
ATOM   796  C C   . VAL A 1 104 ? -23.530 -51.897 29.120  1.00 8.37  ?  327  VAL A C   1 
ATOM   797  O O   . VAL A 1 104 ? -24.601 -51.668 29.698  1.00 11.05 ?  327  VAL A O   1 
ATOM   798  C CB  . VAL A 1 104 ? -22.785 -54.050 30.214  1.00 8.96  ?  327  VAL A CB  1 
ATOM   799  C CG1 . VAL A 1 104 ? -23.483 -54.749 29.029  1.00 10.12 ?  327  VAL A CG1 1 
ATOM   800  C CG2 . VAL A 1 104 ? -21.516 -54.787 30.649  1.00 10.58 ?  327  VAL A CG2 1 
ATOM   801  N N   . GLY A 1 105 ? -23.310 -51.583 27.840  1.00 7.74  ?  328  GLY A N   1 
ATOM   802  C CA  . GLY A 1 105 ? -24.327 -50.921 27.044  1.00 10.24 ?  328  GLY A CA  1 
ATOM   803  C C   . GLY A 1 105 ? -23.791 -50.643 25.654  1.00 9.93  ?  328  GLY A C   1 
ATOM   804  O O   . GLY A 1 105 ? -22.673 -51.037 25.297  1.00 9.53  ?  328  GLY A O   1 
ATOM   805  N N   . LYS A 1 106 ? -24.628 -49.986 24.856  1.00 7.58  ?  329  LYS A N   1 
ATOM   806  C CA  . LYS A 1 106 ? -24.278 -49.617 23.479  1.00 8.63  ?  329  LYS A CA  1 
ATOM   807  C C   . LYS A 1 106 ? -24.161 -48.104 23.421  1.00 7.39  ?  329  LYS A C   1 
ATOM   808  O O   . LYS A 1 106 ? -25.157 -47.396 23.601  1.00 8.71  ?  329  LYS A O   1 
ATOM   809  C CB  . LYS A 1 106 ? -25.336 -50.125 22.511  1.00 9.25  ?  329  LYS A CB  1 
ATOM   810  C CG  . LYS A 1 106 ? -25.539 -51.631 22.600  1.00 10.11 ?  329  LYS A CG  1 
ATOM   811  C CD  . LYS A 1 106 ? -26.909 -52.029 22.065  1.00 10.96 ?  329  LYS A CD  1 
ATOM   812  C CE  . LYS A 1 106 ? -27.045 -53.560 22.063  1.00 12.97 ?  329  LYS A CE  1 
ATOM   813  N NZ  . LYS A 1 106 ? -28.491 -53.915 21.835  1.00 11.35 ?  329  LYS A NZ  1 
ATOM   814  N N   . ILE A 1 107 ? -22.941 -47.604 23.228  1.00 6.49  ?  330  ILE A N   1 
ATOM   815  C CA  . ILE A 1 107 ? -22.656 -46.169 23.204  1.00 6.48  ?  330  ILE A CA  1 
ATOM   816  C C   . ILE A 1 107 ? -22.501 -45.769 21.754  1.00 7.48  ?  330  ILE A C   1 
ATOM   817  O O   . ILE A 1 107 ? -21.660 -46.318 21.028  1.00 6.35  ?  330  ILE A O   1 
ATOM   818  C CB  . ILE A 1 107 ? -21.394 -45.828 24.019  1.00 7.24  ?  330  ILE A CB  1 
ATOM   819  C CG1 . ILE A 1 107 ? -21.645 -46.172 25.494  1.00 8.81  ?  330  ILE A CG1 1 
ATOM   820  C CG2 . ILE A 1 107 ? -21.090 -44.318 23.858  1.00 7.15  ?  330  ILE A CG2 1 
ATOM   821  C CD1 . ILE A 1 107 ? -20.377 -46.133 26.348  1.00 9.92  ?  330  ILE A CD1 1 
ATOM   822  N N   . GLN A 1 108 ? -23.384 -44.879 21.304  1.00 7.81  ?  331  GLN A N   1 
ATOM   823  C CA  . GLN A 1 108 ? -23.366 -44.416 19.921  1.00 7.88  ?  331  GLN A CA  1 
ATOM   824  C C   . GLN A 1 108 ? -22.721 -43.031 19.855  1.00 6.85  ?  331  GLN A C   1 
ATOM   825  O O   . GLN A 1 108 ? -22.903 -42.210 20.738  1.00 6.91  ?  331  GLN A O   1 
ATOM   826  C CB  . GLN A 1 108 ? -24.788 -44.352 19.347  1.00 10.04 ?  331  GLN A CB  1 
ATOM   827  C CG  . GLN A 1 108 ? -24.773 -44.157 17.838  1.00 8.33  ?  331  GLN A CG  1 
ATOM   828  C CD  . GLN A 1 108 ? -26.111 -44.589 17.212  1.00 11.71 ?  331  GLN A CD  1 
ATOM   829  O OE1 . GLN A 1 108 ? -26.983 -43.759 16.953  1.00 14.60 ?  331  GLN A OE1 1 
ATOM   830  N NE2 . GLN A 1 108 ? -26.256 -45.892 16.953  1.00 12.77 ?  331  GLN A NE2 1 
ATOM   831  N N   . GLY A 1 109 ? -21.946 -42.817 18.832  1.00 7.33  ?  332  GLY A N   1 
ATOM   832  C CA  . GLY A 1 109 ? -21.308 -41.508 18.625  1.00 6.93  ?  332  GLY A CA  1 
ATOM   833  C C   . GLY A 1 109 ? -20.798 -41.439 17.186  1.00 8.26  ?  332  GLY A C   1 
ATOM   834  O O   . GLY A 1 109 ? -21.460 -41.915 16.251  1.00 8.06  ?  332  GLY A O   1 
ATOM   835  N N   . VAL A 1 110 ? -19.654 -40.773 16.986  1.00 7.50  ?  333  VAL A N   1 
ATOM   836  C CA  . VAL A 1 110 ? -19.122 -40.544 15.645  1.00 6.35  ?  333  VAL A CA  1 
ATOM   837  C C   . VAL A 1 110 ? -17.651 -40.920 15.644  1.00 6.99  ?  333  VAL A C   1 
ATOM   838  O O   . VAL A 1 110 ? -16.890 -40.525 16.540  1.00 6.53  ?  333  VAL A O   1 
ATOM   839  C CB  . VAL A 1 110 ? -19.308 -39.073 15.189  1.00 6.78  ?  333  VAL A CB  1 
ATOM   840  C CG1 . VAL A 1 110 ? -18.765 -38.853 13.804  1.00 7.42  ?  333  VAL A CG1 1 
ATOM   841  C CG2 . VAL A 1 110 ? -20.805 -38.716 15.242  1.00 6.58  ?  333  VAL A CG2 1 
ATOM   842  N N   . LEU A 1 111 ? -17.263 -41.675 14.643  1.00 5.95  ?  334  LEU A N   1 
ATOM   843  C CA  . LEU A 1 111 ? -15.872 -42.005 14.407  1.00 6.34  ?  334  LEU A CA  1 
ATOM   844  C C   . LEU A 1 111 ? -15.361 -41.046 13.335  1.00 7.80  ?  334  LEU A C   1 
ATOM   845  O O   . LEU A 1 111 ? -15.916 -41.006 12.226  1.00 8.22  ?  334  LEU A O   1 
ATOM   846  C CB  . LEU A 1 111 ? -15.795 -43.458 13.940  1.00 8.14  ?  334  LEU A CB  1 
ATOM   847  C CG  . LEU A 1 111 ? -14.439 -44.131 13.985  1.00 10.46 ?  334  LEU A CG  1 
ATOM   848  C CD1 . LEU A 1 111 ? -13.968 -44.362 15.472  1.00 9.29  ?  334  LEU A CD1 1 
ATOM   849  C CD2 . LEU A 1 111 ? -14.625 -45.493 13.291  1.00 11.62 ?  334  LEU A CD2 1 
ATOM   850  N N   . THR A 1 112 ? -14.357 -40.221 13.676  1.00 7.92  ?  335  THR A N   1 
ATOM   851  C CA  . THR A 1 112 ? -13.781 -39.239 12.743  1.00 5.44  ?  335  THR A CA  1 
ATOM   852  C C   . THR A 1 112 ? -12.326 -39.616 12.422  1.00 7.15  ?  335  THR A C   1 
ATOM   853  O O   . THR A 1 112 ? -11.653 -40.272 13.224  1.00 9.17  ?  335  THR A O   1 
ATOM   854  C CB  . THR A 1 112 ? -13.819 -37.802 13.338  1.00 7.70  ?  335  THR A CB  1 
ATOM   855  O OG1 . THR A 1 112 ? -13.161 -37.762 14.612  1.00 7.49  ?  335  THR A OG1 1 
ATOM   856  C CG2 . THR A 1 112 ? -15.286 -37.328 13.493  1.00 7.87  ?  335  THR A CG2 1 
ATOM   857  N N   . GLN A 1 113 ? -11.850 -39.186 11.252  1.00 6.17  ?  336  GLN A N   1 
ATOM   858  C CA  . GLN A 1 113 ? -10.473 -39.488 10.851  1.00 6.62  ?  336  GLN A CA  1 
ATOM   859  C C   . GLN A 1 113 ? -9.922  -38.358 10.000  1.00 6.91  ?  336  GLN A C   1 
ATOM   860  O O   . GLN A 1 113 ? -10.655 -37.731 9.207   1.00 7.30  ?  336  GLN A O   1 
ATOM   861  C CB  . GLN A 1 113 ? -10.469 -40.812 10.054  1.00 6.74  ?  336  GLN A CB  1 
ATOM   862  C CG  . GLN A 1 113 ? -9.045  -41.223 9.637   1.00 7.16  ?  336  GLN A CG  1 
ATOM   863  C CD  . GLN A 1 113 ? -9.107  -42.544 8.848   1.00 10.17 ?  336  GLN A CD  1 
ATOM   864  O OE1 . GLN A 1 113 ? -9.345  -42.548 7.633   1.00 10.17 ?  336  GLN A OE1 1 
ATOM   865  N NE2 . GLN A 1 113 ? -8.922  -43.674 9.549   1.00 9.79  ?  336  GLN A NE2 1 
ATOM   866  N N   . THR A 1 114 ? -8.607  -38.133 10.126  1.00 7.49  ?  337  THR A N   1 
ATOM   867  C CA  . THR A 1 114 ? -7.867  -37.172 9.303   1.00 7.09  ?  337  THR A CA  1 
ATOM   868  C C   . THR A 1 114 ? -6.739  -37.914 8.615   1.00 8.50  ?  337  THR A C   1 
ATOM   869  O O   . THR A 1 114 ? -6.039  -38.687 9.263   1.00 10.50 ?  337  THR A O   1 
ATOM   870  C CB  . THR A 1 114 ? -7.237  -36.061 10.138  1.00 9.56  ?  337  THR A CB  1 
ATOM   871  O OG1 . THR A 1 114 ? -8.259  -35.280 10.781  1.00 8.57  ?  337  THR A OG1 1 
ATOM   872  C CG2 . THR A 1 114 ? -6.412  -35.141 9.224   1.00 11.57 ?  337  THR A CG2 1 
ATOM   873  N N   . THR A 1 115 ? -6.599  -37.700 7.312   1.00 7.94  ?  338  THR A N   1 
ATOM   874  C CA  . THR A 1 115 ? -5.453  -38.219 6.543   1.00 8.83  ?  338  THR A CA  1 
ATOM   875  C C   . THR A 1 115 ? -4.309  -37.207 6.629   1.00 11.28 ?  338  THR A C   1 
ATOM   876  O O   . THR A 1 115 ? -4.479  -36.062 6.217   1.00 10.80 ?  338  THR A O   1 
ATOM   877  C CB  . THR A 1 115 ? -5.862  -38.436 5.093   1.00 12.62 ?  338  THR A CB  1 
ATOM   878  O OG1 . THR A 1 115 ? -6.942  -39.387 5.006   1.00 12.73 ?  338  THR A OG1 1 
ATOM   879  C CG2 . THR A 1 115 ? -4.645  -38.993 4.271   1.00 12.14 ?  338  THR A CG2 1 
ATOM   880  N N   . ARG A 1 116 ? -3.140  -37.627 7.129   1.00 10.68 ?  339  ARG A N   1 
ATOM   881  C CA  . ARG A 1 116 ? -2.162  -36.621 7.503   1.00 13.55 ?  339  ARG A CA  1 
ATOM   882  C C   . ARG A 1 116 ? -1.519  -35.953 6.292   1.00 16.29 ?  339  ARG A C   1 
ATOM   883  O O   . ARG A 1 116 ? -1.081  -34.808 6.404   1.00 15.60 ?  339  ARG A O   1 
ATOM   884  C CB  . ARG A 1 116 ? -1.110  -37.243 8.446   1.00 16.07 ?  339  ARG A CB  1 
ATOM   885  C CG  . ARG A 1 116 ? -0.294  -38.307 7.788   1.00 16.59 ?  339  ARG A CG  1 
ATOM   886  C CD  . ARG A 1 116 ? 0.791   -38.893 8.772   1.00 16.66 ?  339  ARG A CD  1 
ATOM   887  N NE  . ARG A 1 116 ? 0.184   -39.446 9.981   1.00 18.33 ?  339  ARG A NE  1 
ATOM   888  C CZ  . ARG A 1 116 ? -0.259  -40.693 10.046  1.00 15.37 ?  339  ARG A CZ  1 
ATOM   889  N NH1 . ARG A 1 116 ? -0.137  -41.520 9.025   1.00 14.43 ?  339  ARG A NH1 1 
ATOM   890  N NH2 . ARG A 1 116 ? -0.890  -41.101 11.137  1.00 16.82 ?  339  ARG A NH2 1 
ATOM   891  N N   . THR A 1 117 ? -1.487  -36.622 5.152   1.00 15.39 ?  340  THR A N   1 
ATOM   892  C CA  . THR A 1 117 ? -0.767  -36.081 3.995   1.00 16.15 ?  340  THR A CA  1 
ATOM   893  C C   . THR A 1 117 ? -1.466  -34.880 3.360   1.00 16.44 ?  340  THR A C   1 
ATOM   894  O O   . THR A 1 117 ? -0.796  -33.942 2.921   1.00 18.61 ?  340  THR A O   1 
ATOM   895  C CB  . THR A 1 117 ? -0.559  -37.179 2.968   1.00 19.04 ?  340  THR A CB  1 
ATOM   896  O OG1 . THR A 1 117 ? -1.798  -37.855 2.688   1.00 20.80 ?  340  THR A OG1 1 
ATOM   897  C CG2 . THR A 1 117 ? 0.481   -38.168 3.524   1.00 21.03 ?  340  THR A CG2 1 
ATOM   898  N N   . ASP A 1 118 ? -2.799  -34.878 3.287   1.00 12.59 ?  341  ASP A N   1 
ATOM   899  C CA  . ASP A 1 118 ? -3.506  -33.755 2.690   1.00 12.99 ?  341  ASP A CA  1 
ATOM   900  C C   . ASP A 1 118 ? -4.479  -33.071 3.641   1.00 11.47 ?  341  ASP A C   1 
ATOM   901  O O   . ASP A 1 118 ? -5.071  -32.056 3.240   1.00 10.55 ?  341  ASP A O   1 
ATOM   902  C CB  . ASP A 1 118 ? -4.283  -34.152 1.425   1.00 10.61 ?  341  ASP A CB  1 
ATOM   903  C CG  . ASP A 1 118 ? -5.319  -35.271 1.655   1.00 12.00 ?  341  ASP A CG  1 
ATOM   904  O OD1 . ASP A 1 118 ? -5.470  -35.749 2.807   1.00 11.14 ?  341  ASP A OD1 1 
ATOM   905  O OD2 . ASP A 1 118 ? -6.029  -35.665 0.681   1.00 15.50 -1 341  ASP A OD2 1 
ATOM   906  N N   . GLY A 1 119 ? -4.623  -33.566 4.873   1.00 10.00 ?  342  GLY A N   1 
ATOM   907  C CA  . GLY A 1 119 ? -5.614  -32.992 5.787   1.00 9.09  ?  342  GLY A CA  1 
ATOM   908  C C   . GLY A 1 119 ? -7.062  -33.257 5.402   1.00 8.82  ?  342  GLY A C   1 
ATOM   909  O O   . GLY A 1 119 ? -7.960  -32.551 5.881   1.00 8.82  ?  342  GLY A O   1 
ATOM   910  N N   . SER A 1 120 ? -7.324  -34.247 4.544   1.00 7.15  ?  343  SER A N   1 
ATOM   911  C CA  . SER A 1 120 ? -8.701  -34.605 4.232   1.00 7.36  ?  343  SER A CA  1 
ATOM   912  C C   . SER A 1 120 ? -9.314  -35.335 5.418   1.00 7.72  ?  343  SER A C   1 
ATOM   913  O O   . SER A 1 120 ? -8.602  -35.948 6.234   1.00 8.54  ?  343  SER A O   1 
ATOM   914  C CB  . SER A 1 120 ? -8.775  -35.496 2.975   1.00 10.09 ?  343  SER A CB  1 
ATOM   915  O OG  . SER A 1 120 ? -8.014  -36.724 3.195   1.00 10.94 ?  343  SER A OG  1 
ATOM   916  N N   . THR A 1 121 ? -10.654 -35.227 5.548   1.00 7.61  ?  344  THR A N   1 
ATOM   917  C CA  . THR A 1 121 ? -11.313 -35.721 6.757   1.00 6.36  ?  344  THR A CA  1 
ATOM   918  C C   . THR A 1 121 ? -12.623 -36.439 6.417   1.00 7.52  ?  344  THR A C   1 
ATOM   919  O O   . THR A 1 121 ? -13.192 -36.299 5.327   1.00 7.52  ?  344  THR A O   1 
ATOM   920  C CB  . THR A 1 121 ? -11.615 -34.595 7.769   1.00 7.60  ?  344  THR A CB  1 
ATOM   921  O OG1 . THR A 1 121 ? -12.563 -33.633 7.251   1.00 7.07  ?  344  THR A OG1 1 
ATOM   922  C CG2 . THR A 1 121 ? -10.340 -33.860 8.151   1.00 5.96  ?  344  THR A CG2 1 
ATOM   923  N N   . ARG A 1 122 ? -13.089 -37.242 7.383   1.00 8.52  ?  345  ARG A N   1 
ATOM   924  C CA  . ARG A 1 122 ? -14.305 -38.033 7.187   1.00 8.05  ?  345  ARG A CA  1 
ATOM   925  C C   . ARG A 1 122 ? -14.869 -38.407 8.545   1.00 8.51  ?  345  ARG A C   1 
ATOM   926  O O   . ARG A 1 122 ? -14.133 -38.521 9.513   1.00 8.39  ?  345  ARG A O   1 
ATOM   927  C CB  . ARG A 1 122 ? -14.050 -39.313 6.340   1.00 9.71  ?  345  ARG A CB  1 
ATOM   928  C CG  . ARG A 1 122 ? -12.877 -40.182 6.953   1.00 10.16 ?  345  ARG A CG  1 
ATOM   929  C CD  . ARG A 1 122 ? -12.188 -41.035 5.890   1.00 12.49 ?  345  ARG A CD  1 
ATOM   930  N NE  . ARG A 1 122 ? -11.558 -40.206 4.866   1.00 12.52 ?  345  ARG A NE  1 
ATOM   931  C CZ  . ARG A 1 122 ? -10.351 -39.672 5.021   1.00 10.98 ?  345  ARG A CZ  1 
ATOM   932  N NH1 . ARG A 1 122 ? -9.592  -39.977 6.081   1.00 10.32 ?  345  ARG A NH1 1 
ATOM   933  N NH2 . ARG A 1 122 ? -9.920  -38.783 4.123   1.00 9.56  ?  345  ARG A NH2 1 
ATOM   934  N N   . GLY A 1 123 ? -16.182 -38.647 8.606   1.00 8.98  ?  346  GLY A N   1 
ATOM   935  C CA  . GLY A 1 123 ? -16.816 -38.970 9.871   1.00 9.98  ?  346  GLY A CA  1 
ATOM   936  C C   . GLY A 1 123 ? -18.025 -39.836 9.617   1.00 12.45 ?  346  GLY A C   1 
ATOM   937  O O   . GLY A 1 123 ? -18.748 -39.629 8.624   1.00 11.50 ?  346  GLY A O   1 
ATOM   938  N N   . HIS A 1 124 ? -18.230 -40.831 10.484  1.00 8.74  ?  347  HIS A N   1 
ATOM   939  C CA  . HIS A 1 124 ? -19.310 -41.804 10.294  1.00 8.56  ?  347  HIS A CA  1 
ATOM   940  C C   . HIS A 1 124 ? -19.933 -42.148 11.619  1.00 7.66  ?  347  HIS A C   1 
ATOM   941  O O   . HIS A 1 124 ? -19.241 -42.278 12.642  1.00 7.02  ?  347  HIS A O   1 
ATOM   942  C CB  . HIS A 1 124 ? -18.776 -43.117 9.673   1.00 10.41 ?  347  HIS A CB  1 
ATOM   943  C CG  . HIS A 1 124 ? -18.372 -42.933 8.237   1.00 13.59 ?  347  HIS A CG  1 
ATOM   944  N ND1 . HIS A 1 124 ? -19.258 -43.113 7.200   1.00 16.13 ?  347  HIS A ND1 1 
ATOM   945  C CD2 . HIS A 1 124 ? -17.207 -42.518 7.675   1.00 12.55 ?  347  HIS A CD2 1 
ATOM   946  C CE1 . HIS A 1 124 ? -18.660 -42.824 6.055   1.00 15.60 ?  347  HIS A CE1 1 
ATOM   947  N NE2 . HIS A 1 124 ? -17.425 -42.432 6.318   1.00 12.96 ?  347  HIS A NE2 1 
ATOM   948  N N   . LYS A 1 125 ? -21.270 -42.333 11.594  1.00 7.96  ?  348  LYS A N   1 
ATOM   949  C CA  . LYS A 1 125 ? -21.967 -42.908 12.738  1.00 7.40  ?  348  LYS A CA  1 
ATOM   950  C C   . LYS A 1 125 ? -21.329 -44.227 13.176  1.00 8.16  ?  348  LYS A C   1 
ATOM   951  O O   . LYS A 1 125 ? -20.998 -45.089 12.356  1.00 9.17  ?  348  LYS A O   1 
ATOM   952  C CB  . LYS A 1 125 ? -23.449 -43.122 12.336  1.00 10.91 ?  348  LYS A CB  1 
ATOM   953  C CG  . LYS A 1 125 ? -24.372 -43.508 13.452  1.00 13.69 ?  348  LYS A CG  1 
ATOM   954  C CD  . LYS A 1 125 ? -25.754 -43.853 12.794  1.00 17.62 ?  348  LYS A CD  1 
ATOM   955  C CE  . LYS A 1 125 ? -26.783 -44.248 13.805  1.00 24.99 ?  348  LYS A CE  1 
ATOM   956  N NZ  . LYS A 1 125 ? -28.131 -44.226 13.088  1.00 25.04 ?  348  LYS A NZ  1 
ATOM   957  N N   . ALA A 1 126 ? -21.162 -44.361 14.478  1.00 6.37  ?  349  ALA A N   1 
ATOM   958  C CA  . ALA A 1 126 ? -20.446 -45.514 15.035  1.00 7.03  ?  349  ALA A CA  1 
ATOM   959  C C   . ALA A 1 126 ? -20.986 -45.892 16.414  1.00 7.64  ?  349  ALA A C   1 
ATOM   960  O O   . ALA A 1 126 ? -21.349 -45.023 17.235  1.00 8.66  ?  349  ALA A O   1 
ATOM   961  C CB  . ALA A 1 126 ? -18.925 -45.200 15.123  1.00 8.90  ?  349  ALA A CB  1 
ATOM   962  N N   . THR A 1 127 ? -21.061 -47.229 16.664  1.00 7.68  ?  350  THR A N   1 
ATOM   963  C CA  . THR A 1 127 ? -21.534 -47.705 17.956  1.00 6.71  ?  350  THR A CA  1 
ATOM   964  C C   . THR A 1 127 ? -20.508 -48.687 18.526  1.00 6.92  ?  350  THR A C   1 
ATOM   965  O O   . THR A 1 127 ? -19.929 -49.490 17.774  1.00 8.60  ?  350  THR A O   1 
ATOM   966  C CB  . THR A 1 127 ? -22.919 -48.424 17.823  1.00 8.92  ?  350  THR A CB  1 
ATOM   967  O OG1 . THR A 1 127 ? -23.832 -47.536 17.136  1.00 10.19 ?  350  THR A OG1 1 
ATOM   968  C CG2 . THR A 1 127 ? -23.471 -48.810 19.206  1.00 10.22 ?  350  THR A CG2 1 
ATOM   969  N N   . VAL A 1 128 ? -20.198 -48.537 19.814  1.00 6.78  ?  351  VAL A N   1 
ATOM   970  C CA  . VAL A 1 128 ? -19.357 -49.508 20.517  1.00 7.86  ?  351  VAL A CA  1 
ATOM   971  C C   . VAL A 1 128 ? -20.228 -50.284 21.492  1.00 8.59  ?  351  VAL A C   1 
ATOM   972  O O   . VAL A 1 128 ? -21.072 -49.724 22.213  1.00 8.79  ?  351  VAL A O   1 
ATOM   973  C CB  . VAL A 1 128 ? -18.134 -48.876 21.206  1.00 8.50  ?  351  VAL A CB  1 
ATOM   974  C CG1 . VAL A 1 128 ? -18.556 -47.752 22.210  1.00 8.54  ?  351  VAL A CG1 1 
ATOM   975  C CG2 . VAL A 1 128 ? -17.266 -49.995 21.849  1.00 10.29 ?  351  VAL A CG2 1 
ATOM   976  N N   . TYR A 1 129 ? -20.057 -51.611 21.468  1.00 8.13  ?  352  TYR A N   1 
ATOM   977  C CA  . TYR A 1 129 ? -20.880 -52.570 22.209  1.00 9.54  ?  352  TYR A CA  1 
ATOM   978  C C   . TYR A 1 129 ? -20.037 -53.033 23.398  1.00 9.34  ?  352  TYR A C   1 
ATOM   979  O O   . TYR A 1 129 ? -19.195 -53.935 23.255  1.00 10.54 ?  352  TYR A O   1 
ATOM   980  C CB  . TYR A 1 129 ? -21.229 -53.746 21.290  1.00 10.19 ?  352  TYR A CB  1 
ATOM   981  C CG  . TYR A 1 129 ? -22.186 -53.362 20.175  1.00 10.23 ?  352  TYR A CG  1 
ATOM   982  C CD1 . TYR A 1 129 ? -21.764 -52.614 19.050  1.00 10.67 ?  352  TYR A CD1 1 
ATOM   983  C CD2 . TYR A 1 129 ? -23.519 -53.634 20.319  1.00 11.25 ?  352  TYR A CD2 1 
ATOM   984  C CE1 . TYR A 1 129 ? -22.713 -52.211 18.067  1.00 12.05 ?  352  TYR A CE1 1 
ATOM   985  C CE2 . TYR A 1 129 ? -24.456 -53.256 19.374  1.00 12.82 ?  352  TYR A CE2 1 
ATOM   986  C CZ  . TYR A 1 129 ? -24.050 -52.549 18.251  1.00 12.71 ?  352  TYR A CZ  1 
ATOM   987  O OH  . TYR A 1 129 ? -25.000 -52.129 17.327  1.00 12.92 ?  352  TYR A OH  1 
ATOM   988  N N   . THR A 1 130 ? -20.232 -52.404 24.557  1.00 8.08  ?  353  THR A N   1 
ATOM   989  C CA  . THR A 1 130 ? -19.269 -52.670 25.637  1.00 7.49  ?  353  THR A CA  1 
ATOM   990  C C   . THR A 1 130 ? -19.550 -53.996 26.322  1.00 9.83  ?  353  THR A C   1 
ATOM   991  O O   . THR A 1 130 ? -18.781 -54.382 27.216  1.00 11.04 ?  353  THR A O   1 
ATOM   992  C CB  . THR A 1 130 ? -19.240 -51.545 26.693  1.00 7.93  ?  353  THR A CB  1 
ATOM   993  O OG1 . THR A 1 130 ? -20.464 -51.551 27.437  1.00 7.91  ?  353  THR A OG1 1 
ATOM   994  C CG2 . THR A 1 130 ? -19.036 -50.140 26.026  1.00 8.99  ?  353  THR A CG2 1 
ATOM   995  N N   . GLY A 1 131 ? -20.653 -54.641 25.993  1.00 8.78  ?  354  GLY A N   1 
ATOM   996  C CA  . GLY A 1 131 ? -20.914 -56.008 26.443  1.00 12.03 ?  354  GLY A CA  1 
ATOM   997  C C   . GLY A 1 131 ? -20.495 -57.074 25.434  1.00 11.85 ?  354  GLY A C   1 
ATOM   998  O O   . GLY A 1 131 ? -20.784 -58.275 25.612  1.00 14.16 ?  354  GLY A O   1 
ATOM   999  N N   . SER A 1 132 ? -19.870 -56.673 24.331  1.00 9.18  ?  355  SER A N   1 
ATOM   1000 C CA  . SER A 1 132 ? -19.465 -57.593 23.269  1.00 11.23 ?  355  SER A CA  1 
ATOM   1001 C C   . SER A 1 132 ? -18.309 -58.465 23.743  1.00 12.28 ?  355  SER A C   1 
ATOM   1002 O O   . SER A 1 132 ? -17.449 -58.008 24.484  1.00 12.20 ?  355  SER A O   1 
ATOM   1003 C CB  . SER A 1 132 ? -18.990 -56.799 22.026  1.00 12.87 ?  355  SER A CB  1 
ATOM   1004 O OG  . SER A 1 132 ? -18.251 -57.666 21.181  1.00 15.90 ?  355  SER A OG  1 
ATOM   1005 N N   . ALA A 1 133 ? -18.248 -59.706 23.226  1.00 12.33 ?  356  ALA A N   1 
ATOM   1006 C CA  . ALA A 1 133 ? -17.132 -60.587 23.572  1.00 13.97 ?  356  ALA A CA  1 
ATOM   1007 C C   . ALA A 1 133 ? -15.785 -59.983 23.172  1.00 15.28 ?  356  ALA A C   1 
ATOM   1008 O O   . ALA A 1 133 ? -14.748 -60.279 23.794  1.00 14.15 ?  356  ALA A O   1 
ATOM   1009 C CB  . ALA A 1 133 ? -17.357 -61.949 22.901  1.00 15.18 ?  356  ALA A CB  1 
ATOM   1010 N N   . ASP A 1 134 ? -15.761 -59.117 22.157  1.00 13.63 ?  357  ASP A N   1 
ATOM   1011 C CA  . ASP A 1 134 ? -14.507 -58.607 21.646  1.00 16.37 ?  357  ASP A CA  1 
ATOM   1012 C C   . ASP A 1 134 ? -14.136 -57.232 22.195  1.00 14.21 ?  357  ASP A C   1 
ATOM   1013 O O   . ASP A 1 134 ? -13.075 -56.728 21.856  1.00 18.80 ?  357  ASP A O   1 
ATOM   1014 C CB  . ASP A 1 134 ? -14.542 -58.569 20.104  1.00 17.96 ?  357  ASP A CB  1 
ATOM   1015 C CG  . ASP A 1 134 ? -14.761 -59.962 19.494  1.00 25.73 ?  357  ASP A CG  1 
ATOM   1016 O OD1 . ASP A 1 134 ? -14.009 -60.875 19.895  1.00 34.72 ?  357  ASP A OD1 1 
ATOM   1017 O OD2 . ASP A 1 134 ? -15.685 -60.132 18.651  1.00 31.92 -1 357  ASP A OD2 1 
ATOM   1018 N N   . PHE A 1 135 ? -14.962 -56.635 23.059  1.00 11.07 ?  358  PHE A N   1 
ATOM   1019 C CA  . PHE A 1 135 ? -14.634 -55.360 23.707  1.00 11.70 ?  358  PHE A CA  1 
ATOM   1020 C C   . PHE A 1 135 ? -13.517 -55.612 24.711  1.00 10.94 ?  358  PHE A C   1 
ATOM   1021 O O   . PHE A 1 135 ? -13.762 -56.240 25.748  1.00 10.60 ?  358  PHE A O   1 
ATOM   1022 C CB  . PHE A 1 135 ? -15.875 -54.795 24.407  1.00 10.65 ?  358  PHE A CB  1 
ATOM   1023 C CG  . PHE A 1 135 ? -15.650 -53.502 25.152  1.00 10.21 ?  358  PHE A CG  1 
ATOM   1024 C CD1 . PHE A 1 135 ? -15.498 -52.299 24.446  1.00 9.19  ?  358  PHE A CD1 1 
ATOM   1025 C CD2 . PHE A 1 135 ? -15.606 -53.471 26.568  1.00 9.45  ?  358  PHE A CD2 1 
ATOM   1026 C CE1 . PHE A 1 135 ? -15.336 -51.085 25.151  1.00 9.78  ?  358  PHE A CE1 1 
ATOM   1027 C CE2 . PHE A 1 135 ? -15.446 -52.265 27.260  1.00 10.97 ?  358  PHE A CE2 1 
ATOM   1028 C CZ  . PHE A 1 135 ? -15.297 -51.060 26.523  1.00 9.39  ?  358  PHE A CZ  1 
ATOM   1029 N N   . ALA A 1 136 ? -12.305 -55.157 24.410  1.00 9.12  ?  359  ALA A N   1 
ATOM   1030 C CA  . ALA A 1 136 ? -11.140 -55.498 25.227  1.00 9.20  ?  359  ALA A CA  1 
ATOM   1031 C C   . ALA A 1 136 ? -10.211 -54.296 25.340  1.00 9.64  ?  359  ALA A C   1 
ATOM   1032 O O   . ALA A 1 136 ? -9.021  -54.362 25.014  1.00 9.78  ?  359  ALA A O   1 
ATOM   1033 C CB  . ALA A 1 136 ? -10.420 -56.727 24.637  1.00 7.41  ?  359  ALA A CB  1 
ATOM   1034 N N   . PRO A 1 137 ? -10.713 -53.172 25.865  1.00 8.98  ?  360  PRO A N   1 
ATOM   1035 C CA  . PRO A 1 137 ? -9.868  -51.971 25.940  1.00 8.86  ?  360  PRO A CA  1 
ATOM   1036 C C   . PRO A 1 137 ? -8.621  -52.157 26.795  1.00 9.88  ?  360  PRO A C   1 
ATOM   1037 O O   . PRO A 1 137 ? -7.595  -51.548 26.497  1.00 9.28  ?  360  PRO A O   1 
ATOM   1038 C CB  . PRO A 1 137 ? -10.823 -50.927 26.555  1.00 9.43  ?  360  PRO A CB  1 
ATOM   1039 C CG  . PRO A 1 137 ? -11.817 -51.785 27.354  1.00 8.43  ?  360  PRO A CG  1 
ATOM   1040 C CD  . PRO A 1 137 ? -12.053 -52.968 26.472  1.00 7.73  ?  360  PRO A CD  1 
ATOM   1041 N N   . LYS A 1 138 ? -8.668  -53.018 27.832  1.00 8.88  ?  361  LYS A N   1 
ATOM   1042 C CA  . LYS A 1 138 ? -7.451  -53.236 28.601  1.00 11.72 ?  361  LYS A CA  1 
ATOM   1043 C C   . LYS A 1 138 ? -6.350  -53.864 27.751  1.00 10.45 ?  361  LYS A C   1 
ATOM   1044 O O   . LYS A 1 138 ? -5.150  -53.617 28.013  1.00 11.02 ?  361  LYS A O   1 
ATOM   1045 C CB  . LYS A 1 138 ? -7.769  -54.099 29.813  1.00 10.13 ?  361  LYS A CB  1 
ATOM   1046 C CG  . LYS A 1 138 ? -6.494  -54.544 30.636  1.00 9.95  ?  361  LYS A CG  1 
ATOM   1047 C CD  . LYS A 1 138 ? -5.775  -53.349 31.294  1.00 10.69 ?  361  LYS A CD  1 
ATOM   1048 C CE  . LYS A 1 138 ? -4.618  -53.888 32.201  1.00 14.99 ?  361  LYS A CE  1 
ATOM   1049 N NZ  . LYS A 1 138 ? -3.878  -52.725 32.787  1.00 14.05 ?  361  LYS A NZ  1 
ATOM   1050 N N   . LEU A 1 139 ? -6.725  -54.676 26.753  1.00 9.78  ?  362  LEU A N   1 
ATOM   1051 C CA  . LEU A 1 139 ? -5.738  -55.226 25.817  1.00 12.51 ?  362  LEU A CA  1 
ATOM   1052 C C   . LEU A 1 139 ? -5.441  -54.275 24.658  1.00 13.31 ?  362  LEU A C   1 
ATOM   1053 O O   . LEU A 1 139 ? -4.629  -54.604 23.786  1.00 15.45 ?  362  LEU A O   1 
ATOM   1054 C CB  . LEU A 1 139 ? -6.212  -56.594 25.288  1.00 11.77 ?  362  LEU A CB  1 
ATOM   1055 C CG  . LEU A 1 139 ? -6.599  -57.696 26.282  1.00 14.51 ?  362  LEU A CG  1 
ATOM   1056 C CD1 . LEU A 1 139 ? -7.000  -58.969 25.498  1.00 15.40 ?  362  LEU A CD1 1 
ATOM   1057 C CD2 . LEU A 1 139 ? -5.398  -57.967 27.171  1.00 15.83 ?  362  LEU A CD2 1 
ATOM   1058 N N   . GLY A 1 140 ? -6.073  -53.106 24.621  1.00 9.39  ?  363  GLY A N   1 
ATOM   1059 C CA  . GLY A 1 140 ? -5.822  -52.148 23.553  1.00 11.18 ?  363  GLY A CA  1 
ATOM   1060 C C   . GLY A 1 140 ? -6.683  -52.283 22.320  1.00 9.09  ?  363  GLY A C   1 
ATOM   1061 O O   . GLY A 1 140 ? -6.337  -51.728 21.268  1.00 8.85  ?  363  GLY A O   1 
ATOM   1062 N N   . ARG A 1 141 ? -7.784  -53.010 22.393  1.00 9.67  ?  364  ARG A N   1 
ATOM   1063 C CA  . ARG A 1 141 ? -8.611  -53.251 21.207  1.00 11.78 ?  364  ARG A CA  1 
ATOM   1064 C C   . ARG A 1 141 ? -10.089 -53.066 21.527  1.00 10.75 ?  364  ARG A C   1 
ATOM   1065 O O   . ARG A 1 141 ? -10.606 -53.681 22.468  1.00 9.83  ?  364  ARG A O   1 
ATOM   1066 C CB  . ARG A 1 141 ? -8.416  -54.674 20.644  1.00 14.69 ?  364  ARG A CB  1 
ATOM   1067 C CG  . ARG A 1 141 ? -7.019  -55.193 20.796  1.00 23.32 ?  364  ARG A CG  1 
ATOM   1068 C CD  . ARG A 1 141 ? -6.785  -56.309 19.812  1.00 31.58 ?  364  ARG A CD  1 
ATOM   1069 N NE  . ARG A 1 141 ? -7.184  -57.586 20.400  1.00 36.28 ?  364  ARG A NE  1 
ATOM   1070 C CZ  . ARG A 1 141 ? -6.438  -58.275 21.260  1.00 40.37 ?  364  ARG A CZ  1 
ATOM   1071 N NH1 . ARG A 1 141 ? -5.247  -57.837 21.644  1.00 36.18 ?  364  ARG A NH1 1 
ATOM   1072 N NH2 . ARG A 1 141 ? -6.899  -59.430 21.746  1.00 42.70 ?  364  ARG A NH2 1 
ATOM   1073 N N   . VAL A 1 142 ? -10.782 -52.272 20.700  1.00 9.12  ?  365  VAL A N   1 
ATOM   1074 C CA  . VAL A 1 142 ? -12.243 -52.214 20.693  1.00 8.35  ?  365  VAL A CA  1 
ATOM   1075 C C   . VAL A 1 142 ? -12.712 -52.208 19.239  1.00 10.38 ?  365  VAL A C   1 
ATOM   1076 O O   . VAL A 1 142 ? -11.913 -52.085 18.306  1.00 12.60 ?  365  VAL A O   1 
ATOM   1077 C CB  . VAL A 1 142 ? -12.785 -50.979 21.442  1.00 10.54 ?  365  VAL A CB  1 
ATOM   1078 C CG1 . VAL A 1 142 ? -12.232 -50.925 22.873  1.00 12.32 ?  365  VAL A CG1 1 
ATOM   1079 C CG2 . VAL A 1 142 ? -12.448 -49.721 20.723  1.00 14.24 ?  365  VAL A CG2 1 
ATOM   1080 N N   . GLN A 1 143 ? -13.980 -52.499 19.035  1.00 10.01 ?  366  GLN A N   1 
ATOM   1081 C CA  . GLN A 1 143 ? -14.531 -52.516 17.674  1.00 10.74 ?  366  GLN A CA  1 
ATOM   1082 C C   . GLN A 1 143 ? -15.684 -51.527 17.581  1.00 9.54  ?  366  GLN A C   1 
ATOM   1083 O O   . GLN A 1 143 ? -16.423 -51.362 18.550  1.00 10.86 ?  366  GLN A O   1 
ATOM   1084 C CB  . GLN A 1 143 ? -15.065 -53.912 17.266  1.00 13.28 ?  366  GLN A CB  1 
ATOM   1085 C CG  . GLN A 1 143 ? -13.947 -54.956 17.381  1.00 12.73 ?  366  GLN A CG  1 
ATOM   1086 C CD  . GLN A 1 143 ? -13.826 -55.444 18.816  1.00 19.63 ?  366  GLN A CD  1 
ATOM   1087 O OE1 . GLN A 1 143 ? -14.831 -55.475 19.566  1.00 17.67 ?  366  GLN A OE1 1 
ATOM   1088 N NE2 . GLN A 1 143 ? -12.579 -55.735 19.251  1.00 18.83 ?  366  GLN A NE2 1 
ATOM   1089 N N   . PHE A 1 144 ? -15.822 -50.889 16.421  1.00 9.66  ?  367  PHE A N   1 
ATOM   1090 C CA  . PHE A 1 144 ? -16.910 -49.956 16.154  1.00 10.48 ?  367  PHE A CA  1 
ATOM   1091 C C   . PHE A 1 144 ? -17.730 -50.472 14.990  1.00 11.14 ?  367  PHE A C   1 
ATOM   1092 O O   . PHE A 1 144 ? -17.175 -50.792 13.943  1.00 11.18 ?  367  PHE A O   1 
ATOM   1093 C CB  . PHE A 1 144 ? -16.378 -48.561 15.827  1.00 9.98  ?  367  PHE A CB  1 
ATOM   1094 C CG  . PHE A 1 144 ? -15.697 -47.918 17.009  1.00 9.05  ?  367  PHE A CG  1 
ATOM   1095 C CD1 . PHE A 1 144 ? -16.476 -47.325 17.988  1.00 8.87  ?  367  PHE A CD1 1 
ATOM   1096 C CD2 . PHE A 1 144 ? -14.306 -47.993 17.174  1.00 11.07 ?  367  PHE A CD2 1 
ATOM   1097 C CE1 . PHE A 1 144 ? -15.895 -46.756 19.116  1.00 7.58  ?  367  PHE A CE1 1 
ATOM   1098 C CE2 . PHE A 1 144 ? -13.705 -47.398 18.320  1.00 10.32 ?  367  PHE A CE2 1 
ATOM   1099 C CZ  . PHE A 1 144 ? -14.507 -46.806 19.296  1.00 7.87  ?  367  PHE A CZ  1 
ATOM   1100 N N   . GLU A 1 145 ? -19.045 -50.513 15.169  1.00 8.71  ?  368  GLU A N   1 
ATOM   1101 C CA  . GLU A 1 145 ? -19.969 -50.813 14.075  1.00 9.71  ?  368  GLU A CA  1 
ATOM   1102 C C   . GLU A 1 145 ? -20.303 -49.491 13.381  1.00 11.46 ?  368  GLU A C   1 
ATOM   1103 O O   . GLU A 1 145 ? -20.724 -48.546 14.056  1.00 11.10 ?  368  GLU A O   1 
ATOM   1104 C CB  . GLU A 1 145 ? -21.228 -51.446 14.648  1.00 11.11 ?  368  GLU A CB  1 
ATOM   1105 C CG  . GLU A 1 145 ? -22.329 -51.664 13.595  1.00 11.16 ?  368  GLU A CG  1 
ATOM   1106 C CD  . GLU A 1 145 ? -23.589 -52.166 14.269  1.00 14.83 ?  368  GLU A CD  1 
ATOM   1107 O OE1 . GLU A 1 145 ? -24.274 -51.346 14.915  1.00 13.83 ?  368  GLU A OE1 1 
ATOM   1108 O OE2 . GLU A 1 145 ? -23.875 -53.371 14.100  1.00 16.71 -1 368  GLU A OE2 1 
ATOM   1109 N N   . THR A 1 146 ? -20.090 -49.405 12.064  1.00 9.67  ?  369  THR A N   1 
ATOM   1110 C CA  . THR A 1 146 ? -20.272 -48.120 11.368  1.00 11.13 ?  369  THR A CA  1 
ATOM   1111 C C   . THR A 1 146 ? -21.221 -48.287 10.188  1.00 13.94 ?  369  THR A C   1 
ATOM   1112 O O   . THR A 1 146 ? -21.821 -49.366 9.995   1.00 13.34 ?  369  THR A O   1 
ATOM   1113 C CB  . THR A 1 146 ? -18.944 -47.517 10.844  1.00 12.08 ?  369  THR A CB  1 
ATOM   1114 O OG1 . THR A 1 146 ? -18.508 -48.195 9.657   1.00 12.57 ?  369  THR A OG1 1 
ATOM   1115 C CG2 . THR A 1 146 ? -17.821 -47.628 11.877  1.00 10.58 ?  369  THR A CG2 1 
ATOM   1116 N N   . ASP A 1 147 ? -21.363 -47.225 9.393   1.00 12.61 ?  370  ASP A N   1 
ATOM   1117 C CA  . ASP A 1 147 ? -22.172 -47.331 8.183   1.00 18.06 ?  370  ASP A CA  1 
ATOM   1118 C C   . ASP A 1 147 ? -21.329 -47.380 6.910   1.00 19.00 ?  370  ASP A C   1 
ATOM   1119 O O   . ASP A 1 147 ? -21.843 -47.104 5.821   1.00 20.13 ?  370  ASP A O   1 
ATOM   1120 C CB  . ASP A 1 147 ? -23.187 -46.186 8.142   1.00 16.63 ?  370  ASP A CB  1 
ATOM   1121 C CG  . ASP A 1 147 ? -22.551 -44.842 7.987   1.00 18.41 ?  370  ASP A CG  1 
ATOM   1122 O OD1 . ASP A 1 147 ? -21.308 -44.722 8.068   1.00 14.44 ?  370  ASP A OD1 1 
ATOM   1123 O OD2 . ASP A 1 147 ? -23.327 -43.893 7.782   1.00 18.63 -1 370  ASP A OD2 1 
ATOM   1124 N N   . THR A 1 148 ? -20.045 -47.749 7.002   1.00 16.37 ?  371  THR A N   1 
ATOM   1125 C CA  . THR A 1 148 ? -19.203 -47.854 5.811   1.00 15.80 ?  371  THR A CA  1 
ATOM   1126 C C   . THR A 1 148 ? -18.359 -49.116 5.904   1.00 18.65 ?  371  THR A C   1 
ATOM   1127 O O   . THR A 1 148 ? -18.017 -49.565 7.005   1.00 14.80 ?  371  THR A O   1 
ATOM   1128 C CB  . THR A 1 148 ? -18.289 -46.594 5.617   1.00 15.94 ?  371  THR A CB  1 
ATOM   1129 O OG1 . THR A 1 148 ? -17.584 -46.693 4.386   1.00 16.28 ?  371  THR A OG1 1 
ATOM   1130 C CG2 . THR A 1 148 ? -17.252 -46.474 6.733   1.00 15.51 ?  371  THR A CG2 1 
ATOM   1131 N N   . ASP A 1 149 ? -18.065 -49.716 4.738   1.00 18.22 ?  372  ASP A N   1 
ATOM   1132 C CA  . ASP A 1 149 ? -17.042 -50.751 4.619   1.00 17.71 ?  372  ASP A CA  1 
ATOM   1133 C C   . ASP A 1 149 ? -15.838 -50.303 3.804   1.00 19.83 ?  372  ASP A C   1 
ATOM   1134 O O   . ASP A 1 149 ? -14.980 -51.132 3.468   1.00 21.35 ?  372  ASP A O   1 
ATOM   1135 C CB  . ASP A 1 149 ? -17.648 -52.022 4.023   1.00 19.09 ?  372  ASP A CB  1 
ATOM   1136 C CG  . ASP A 1 149 ? -18.149 -51.818 2.601   1.00 23.94 ?  372  ASP A CG  1 
ATOM   1137 O OD1 . ASP A 1 149 ? -17.930 -50.750 2.006   1.00 25.67 ?  372  ASP A OD1 1 
ATOM   1138 O OD2 . ASP A 1 149 ? -18.739 -52.759 2.060   1.00 30.64 -1 372  ASP A OD2 1 
ATOM   1139 N N   . ARG A 1 150 ? -15.707 -49.006 3.513   1.00 16.53 ?  373  ARG A N   1 
ATOM   1140 C CA  . ARG A 1 150 ? -14.612 -48.600 2.643   1.00 18.34 ?  373  ARG A CA  1 
ATOM   1141 C C   . ARG A 1 150 ? -13.977 -47.256 2.961   1.00 16.97 ?  373  ARG A C   1 
ATOM   1142 O O   . ARG A 1 150 ? -12.906 -46.965 2.424   1.00 17.55 ?  373  ARG A O   1 
ATOM   1143 C CB  . ARG A 1 150 ? -15.084 -48.566 1.171   1.00 18.71 ?  373  ARG A CB  1 
ATOM   1144 C CG  . ARG A 1 150 ? -16.089 -47.486 0.836   1.00 21.81 ?  373  ARG A CG  1 
ATOM   1145 C CD  . ARG A 1 150 ? -16.876 -47.868 -0.446  1.00 33.07 ?  373  ARG A CD  1 
ATOM   1146 N NE  . ARG A 1 150 ? -17.735 -49.033 -0.241  1.00 44.18 ?  373  ARG A NE  1 
ATOM   1147 C CZ  . ARG A 1 150 ? -18.091 -49.885 -1.197  1.00 47.58 ?  373  ARG A CZ  1 
ATOM   1148 N NH1 . ARG A 1 150 ? -17.701 -49.715 -2.454  1.00 42.61 ?  373  ARG A NH1 1 
ATOM   1149 N NH2 . ARG A 1 150 ? -18.832 -50.947 -0.878  1.00 41.26 ?  373  ARG A NH2 1 
ATOM   1150 N N   . ASP A 1 151 ? -14.588 -46.430 3.824   1.00 16.46 ?  374  ASP A N   1 
ATOM   1151 C CA  . ASP A 1 151 ? -14.142 -45.044 3.830   1.00 16.20 ?  374  ASP A CA  1 
ATOM   1152 C C   . ASP A 1 151 ? -12.952 -44.781 4.770   1.00 18.78 ?  374  ASP A C   1 
ATOM   1153 O O   . ASP A 1 151 ? -12.118 -43.900 4.470   1.00 21.10 ?  374  ASP A O   1 
ATOM   1154 C CB  . ASP A 1 151 ? -15.336 -44.129 4.142   1.00 13.34 ?  374  ASP A CB  1 
ATOM   1155 C CG  . ASP A 1 151 ? -15.084 -42.678 3.741   1.00 16.51 ?  374  ASP A CG  1 
ATOM   1156 O OD1 . ASP A 1 151 ? -14.321 -42.447 2.786   1.00 17.78 ?  374  ASP A OD1 1 
ATOM   1157 O OD2 . ASP A 1 151 ? -15.663 -41.764 4.352   1.00 15.76 -1 374  ASP A OD2 1 
ATOM   1158 N N   . PHE A 1 152 ? -12.761 -45.574 5.831   1.00 14.24 ?  375  PHE A N   1 
ATOM   1159 C CA  . PHE A 1 152 ? -11.681 -45.283 6.776   1.00 12.17 ?  375  PHE A CA  1 
ATOM   1160 C C   . PHE A 1 152 ? -10.354 -45.863 6.300   1.00 15.42 ?  375  PHE A C   1 
ATOM   1161 O O   . PHE A 1 152 ? -10.297 -47.036 5.929   1.00 16.50 ?  375  PHE A O   1 
ATOM   1162 C CB  . PHE A 1 152 ? -12.018 -45.855 8.157   1.00 11.63 ?  375  PHE A CB  1 
ATOM   1163 C CG  . PHE A 1 152 ? -13.080 -45.063 8.881   1.00 11.09 ?  375  PHE A CG  1 
ATOM   1164 C CD1 . PHE A 1 152 ? -12.792 -43.794 9.363   1.00 10.43 ?  375  PHE A CD1 1 
ATOM   1165 C CD2 . PHE A 1 152 ? -14.361 -45.572 9.053   1.00 12.24 ?  375  PHE A CD2 1 
ATOM   1166 C CE1 . PHE A 1 152 ? -13.760 -43.021 10.034  1.00 10.20 ?  375  PHE A CE1 1 
ATOM   1167 C CE2 . PHE A 1 152 ? -15.372 -44.781 9.723   1.00 11.89 ?  375  PHE A CE2 1 
ATOM   1168 C CZ  . PHE A 1 152 ? -15.039 -43.524 10.226  1.00 10.68 ?  375  PHE A CZ  1 
ATOM   1169 N N   . GLU A 1 153 ? -9.292  -45.078 6.370   1.00 12.40 ?  376  GLU A N   1 
ATOM   1170 C CA  . GLU A 1 153 ? -7.978  -45.523 5.927   1.00 11.03 ?  376  GLU A CA  1 
ATOM   1171 C C   . GLU A 1 153 ? -7.220  -46.153 7.078   1.00 12.83 ?  376  GLU A C   1 
ATOM   1172 O O   . GLU A 1 153 ? -7.521  -45.906 8.243   1.00 10.93 ?  376  GLU A O   1 
ATOM   1173 C CB  . GLU A 1 153 ? -7.186  -44.342 5.383   1.00 13.24 ?  376  GLU A CB  1 
ATOM   1174 C CG  . GLU A 1 153 ? -7.908  -43.778 4.179   1.00 15.75 ?  376  GLU A CG  1 
ATOM   1175 C CD  . GLU A 1 153 ? -7.480  -42.385 3.801   1.00 19.88 ?  376  GLU A CD  1 
ATOM   1176 O OE1 . GLU A 1 153 ? -6.463  -41.898 4.342   1.00 17.60 ?  376  GLU A OE1 1 
ATOM   1177 O OE2 . GLU A 1 153 ? -8.220  -41.743 2.997   1.00 26.22 -1 376  GLU A OE2 1 
ATOM   1178 N N   . ALA A 1 154 ? -6.276  -47.037 6.744   1.00 14.23 ?  377  ALA A N   1 
ATOM   1179 C CA  . ALA A 1 154 ? -5.368  -47.613 7.741   1.00 12.76 ?  377  ALA A CA  1 
ATOM   1180 C C   . ALA A 1 154 ? -4.231  -46.652 8.073   1.00 11.42 ?  377  ALA A C   1 
ATOM   1181 O O   . ALA A 1 154 ? -3.876  -45.786 7.274   1.00 12.05 ?  377  ALA A O   1 
ATOM   1182 C CB  . ALA A 1 154 ? -4.779  -48.922 7.190   1.00 14.99 ?  377  ALA A CB  1 
ATOM   1183 N N   . ASN A 1 155 ? -3.616  -46.837 9.252   1.00 12.00 ?  378  ASN A N   1 
ATOM   1184 C CA  . ASN A 1 155 ? -2.493  -45.984 9.712   1.00 13.20 ?  378  ASN A CA  1 
ATOM   1185 C C   . ASN A 1 155 ? -2.777  -44.482 9.615   1.00 13.82 ?  378  ASN A C   1 
ATOM   1186 O O   . ASN A 1 155 ? -1.893  -43.690 9.261   1.00 14.34 ?  378  ASN A O   1 
ATOM   1187 C CB  . ASN A 1 155 ? -1.160  -46.278 8.977   1.00 15.17 ?  378  ASN A CB  1 
ATOM   1188 C CG  . ASN A 1 155 ? -0.587  -47.624 9.314   1.00 26.71 ?  378  ASN A CG  1 
ATOM   1189 O OD1 . ASN A 1 155 ? -1.081  -48.313 10.194  1.00 30.93 ?  378  ASN A OD1 1 
ATOM   1190 N ND2 . ASN A 1 155 ? 0.513   -47.992 8.647   1.00 27.15 ?  378  ASN A ND2 1 
ATOM   1191 N N   . GLN A 1 156 ? -4.000  -44.079 9.993   1.00 11.56 ?  379  GLN A N   1 
ATOM   1192 C CA  . GLN A 1 156 ? -4.366  -42.666 10.100  1.00 11.68 ?  379  GLN A CA  1 
ATOM   1193 C C   . GLN A 1 156 ? -5.083  -42.428 11.420  1.00 9.30  ?  379  GLN A C   1 
ATOM   1194 O O   . GLN A 1 156 ? -5.864  -43.276 11.867  1.00 9.61  ?  379  GLN A O   1 
ATOM   1195 C CB  . GLN A 1 156 ? -5.287  -42.214 8.962   1.00 10.06 ?  379  GLN A CB  1 
ATOM   1196 C CG  . GLN A 1 156 ? -4.639  -42.313 7.537   1.00 11.84 ?  379  GLN A CG  1 
ATOM   1197 C CD  . GLN A 1 156 ? -3.407  -41.402 7.347   1.00 12.40 ?  379  GLN A CD  1 
ATOM   1198 O OE1 . GLN A 1 156 ? -3.198  -40.408 8.029   1.00 11.02 ?  379  GLN A OE1 1 
ATOM   1199 N NE2 . GLN A 1 156 ? -2.541  -41.805 6.392   1.00 16.04 ?  379  GLN A NE2 1 
ATOM   1200 N N   . ASN A 1 157 ? -4.786  -41.297 12.067  1.00 8.97  ?  380  ASN A N   1 
ATOM   1201 C CA  . ASN A 1 157 ? -5.390  -40.992 13.366  1.00 9.94  ?  380  ASN A CA  1 
ATOM   1202 C C   . ASN A 1 157 ? -6.914  -40.968 13.303  1.00 9.07  ?  380  ASN A C   1 
ATOM   1203 O O   . ASN A 1 157 ? -7.501  -40.241 12.472  1.00 9.57  ?  380  ASN A O   1 
ATOM   1204 C CB  . ASN A 1 157 ? -4.916  -39.621 13.845  1.00 9.55  ?  380  ASN A CB  1 
ATOM   1205 C CG  . ASN A 1 157 ? -3.462  -39.604 14.214  1.00 14.28 ?  380  ASN A CG  1 
ATOM   1206 O OD1 . ASN A 1 157 ? -2.763  -40.592 14.069  1.00 14.83 ?  380  ASN A OD1 1 
ATOM   1207 N ND2 . ASN A 1 157 ? -3.020  -38.484 14.774  1.00 18.58 ?  380  ASN A ND2 1 
ATOM   1208 N N   . THR A 1 158 ? -7.558  -41.727 14.221  1.00 6.95  ?  381  THR A N   1 
ATOM   1209 C CA  . THR A 1 158 ? -9.014  -41.902 14.230  1.00 6.75  ?  381  THR A CA  1 
ATOM   1210 C C   . THR A 1 158 ? -9.520  -41.705 15.662  1.00 7.66  ?  381  THR A C   1 
ATOM   1211 O O   . THR A 1 158 ? -8.875  -42.158 16.616  1.00 8.80  ?  381  THR A O   1 
ATOM   1212 C CB  . THR A 1 158 ? -9.361  -43.313 13.716  1.00 8.11  ?  381  THR A CB  1 
ATOM   1213 O OG1 . THR A 1 158 ? -8.643  -43.561 12.486  1.00 9.10  ?  381  THR A OG1 1 
ATOM   1214 C CG2 . THR A 1 158 ? -10.830 -43.470 13.498  1.00 7.06  ?  381  THR A CG2 1 
ATOM   1215 N N   . LYS A 1 159 ? -10.664 -41.018 15.811  1.00 5.51  ?  382  LYS A N   1 
ATOM   1216 C CA  . LYS A 1 159 ? -11.189 -40.705 17.140  1.00 6.19  ?  382  LYS A CA  1 
ATOM   1217 C C   . LYS A 1 159 ? -12.654 -41.102 17.219  1.00 6.44  ?  382  LYS A C   1 
ATOM   1218 O O   . LYS A 1 159 ? -13.389 -40.880 16.258  1.00 6.98  ?  382  LYS A O   1 
ATOM   1219 C CB  . LYS A 1 159 ? -11.077 -39.184 17.448  1.00 6.34  ?  382  LYS A CB  1 
ATOM   1220 C CG  . LYS A 1 159 ? -11.631 -38.875 18.854  1.00 8.34  ?  382  LYS A CG  1 
ATOM   1221 C CD  . LYS A 1 159 ? -11.632 -37.346 19.105  1.00 10.69 ?  382  LYS A CD  1 
ATOM   1222 C CE  . LYS A 1 159 ? -12.366 -37.042 20.415  1.00 11.83 ?  382  LYS A CE  1 
ATOM   1223 N NZ  . LYS A 1 159 ? -12.407 -35.548 20.628  1.00 17.32 ?  382  LYS A NZ  1 
ATOM   1224 N N   . PHE A 1 160 ? -13.084 -41.647 18.367  1.00 5.79  ?  383  PHE A N   1 
ATOM   1225 C CA  . PHE A 1 160 ? -14.521 -41.787 18.637  1.00 6.98  ?  383  PHE A CA  1 
ATOM   1226 C C   . PHE A 1 160 ? -14.970 -40.758 19.678  1.00 7.06  ?  383  PHE A C   1 
ATOM   1227 O O   . PHE A 1 160 ? -14.372 -40.669 20.762  1.00 7.48  ?  383  PHE A O   1 
ATOM   1228 C CB  . PHE A 1 160 ? -14.809 -43.190 19.166  1.00 7.51  ?  383  PHE A CB  1 
ATOM   1229 C CG  . PHE A 1 160 ? -16.251 -43.418 19.564  1.00 7.08  ?  383  PHE A CG  1 
ATOM   1230 C CD1 . PHE A 1 160 ? -17.210 -43.716 18.616  1.00 6.87  ?  383  PHE A CD1 1 
ATOM   1231 C CD2 . PHE A 1 160 ? -16.612 -43.367 20.901  1.00 6.09  ?  383  PHE A CD2 1 
ATOM   1232 C CE1 . PHE A 1 160 ? -18.560 -43.974 18.978  1.00 6.39  ?  383  PHE A CE1 1 
ATOM   1233 C CE2 . PHE A 1 160 ? -17.949 -43.602 21.293  1.00 7.00  ?  383  PHE A CE2 1 
ATOM   1234 C CZ  . PHE A 1 160 ? -18.930 -43.895 20.348  1.00 6.70  ?  383  PHE A CZ  1 
ATOM   1235 N N   . THR A 1 161 ? -16.017 -39.976 19.341  1.00 6.46  ?  384  THR A N   1 
ATOM   1236 C CA  . THR A 1 161 ? -16.663 -39.002 20.231  1.00 5.68  ?  384  THR A CA  1 
ATOM   1237 C C   . THR A 1 161 ? -17.987 -39.605 20.642  1.00 5.72  ?  384  THR A C   1 
ATOM   1238 O O   . THR A 1 161 ? -18.823 -39.888 19.764  1.00 7.31  ?  384  THR A O   1 
ATOM   1239 C CB  . THR A 1 161 ? -16.879 -37.656 19.536  1.00 5.91  ?  384  THR A CB  1 
ATOM   1240 O OG1 . THR A 1 161 ? -15.562 -37.119 19.169  1.00 7.81  ?  384  THR A OG1 1 
ATOM   1241 C CG2 . THR A 1 161 ? -17.587 -36.686 20.502  1.00 7.12  ?  384  THR A CG2 1 
ATOM   1242 N N   . PRO A 1 162 ? -18.227 -39.826 21.914  1.00 5.80  ?  385  PRO A N   1 
ATOM   1243 C CA  . PRO A 1 162 ? -19.518 -40.399 22.332  1.00 6.08  ?  385  PRO A CA  1 
ATOM   1244 C C   . PRO A 1 162 ? -20.629 -39.357 22.299  1.00 7.49  ?  385  PRO A C   1 
ATOM   1245 O O   . PRO A 1 162 ? -20.413 -38.175 22.539  1.00 6.95  ?  385  PRO A O   1 
ATOM   1246 C CB  . PRO A 1 162 ? -19.238 -40.858 23.768  1.00 5.88  ?  385  PRO A CB  1 
ATOM   1247 C CG  . PRO A 1 162 ? -18.210 -39.780 24.279  1.00 6.96  ?  385  PRO A CG  1 
ATOM   1248 C CD  . PRO A 1 162 ? -17.346 -39.491 23.058  1.00 7.06  ?  385  PRO A CD  1 
ATOM   1249 N N   . VAL A 1 163 ? -21.866 -39.816 22.021  1.00 7.01  ?  386  VAL A N   1 
ATOM   1250 C CA  . VAL A 1 163 ? -23.051 -38.961 22.057  1.00 5.86  ?  386  VAL A CA  1 
ATOM   1251 C C   . VAL A 1 163 ? -24.081 -39.476 23.060  1.00 6.37  ?  386  VAL A C   1 
ATOM   1252 O O   . VAL A 1 163 ? -24.577 -38.717 23.903  1.00 8.11  ?  386  VAL A O   1 
ATOM   1253 C CB  . VAL A 1 163 ? -23.683 -38.814 20.646  1.00 7.48  ?  386  VAL A CB  1 
ATOM   1254 C CG1 . VAL A 1 163 ? -25.033 -38.063 20.705  1.00 8.84  ?  386  VAL A CG1 1 
ATOM   1255 C CG2 . VAL A 1 163 ? -22.738 -38.061 19.730  1.00 8.02  ?  386  VAL A CG2 1 
ATOM   1256 N N   . GLY A 1 164 ? -24.450 -40.745 22.949  1.00 6.27  ?  387  GLY A N   1 
ATOM   1257 C CA  . GLY A 1 164 ? -25.552 -41.263 23.750  1.00 6.76  ?  387  GLY A CA  1 
ATOM   1258 C C   . GLY A 1 164 ? -25.595 -42.778 23.710  1.00 6.81  ?  387  GLY A C   1 
ATOM   1259 O O   . GLY A 1 164 ? -24.617 -43.433 23.343  1.00 8.11  ?  387  GLY A O   1 
ATOM   1260 N N   . VAL A 1 165 ? -26.746 -43.329 24.113  1.00 7.23  ?  388  VAL A N   1 
ATOM   1261 C CA  . VAL A 1 165 ? -26.901 -44.778 24.254  1.00 8.32  ?  388  VAL A CA  1 
ATOM   1262 C C   . VAL A 1 165 ? -28.106 -45.217 23.421  1.00 8.81  ?  388  VAL A C   1 
ATOM   1263 O O   . VAL A 1 165 ? -29.018 -44.430 23.127  1.00 8.33  ?  388  VAL A O   1 
ATOM   1264 C CB  . VAL A 1 165 ? -27.058 -45.226 25.733  1.00 8.67  ?  388  VAL A CB  1 
ATOM   1265 C CG1 . VAL A 1 165 ? -25.702 -44.990 26.497  1.00 10.37 ?  388  VAL A CG1 1 
ATOM   1266 C CG2 . VAL A 1 165 ? -28.180 -44.438 26.474  1.00 8.83  ?  388  VAL A CG2 1 
ATOM   1267 N N   . ILE A 1 166 ? -28.126 -46.509 23.092  1.00 7.99  ?  389  ILE A N   1 
ATOM   1268 C CA  . ILE A 1 166 ? -29.227 -47.081 22.312  1.00 7.94  ?  389  ILE A CA  1 
ATOM   1269 C C   . ILE A 1 166 ? -29.737 -48.360 22.970  1.00 8.98  ?  389  ILE A C   1 
ATOM   1270 O O   . ILE A 1 166 ? -29.110 -48.924 23.852  1.00 10.24 ?  389  ILE A O   1 
ATOM   1271 C CB  . ILE A 1 166 ? -28.834 -47.359 20.856  1.00 10.78 ?  389  ILE A CB  1 
ATOM   1272 C CG1 . ILE A 1 166 ? -27.725 -48.418 20.754  1.00 11.67 ?  389  ILE A CG1 1 
ATOM   1273 C CG2 . ILE A 1 166 ? -28.412 -46.060 20.157  1.00 11.28 ?  389  ILE A CG2 1 
ATOM   1274 C CD1 . ILE A 1 166 ? -27.482 -48.814 19.297  1.00 12.66 ?  389  ILE A CD1 1 
ATOM   1275 N N   . GLN A 1 167 ? -30.911 -48.785 22.519  1.00 9.29  ?  390  GLN A N   1 
ATOM   1276 C CA  . GLN A 1 167 ? -31.538 -50.031 22.976  1.00 9.65  ?  390  GLN A CA  1 
ATOM   1277 C C   . GLN A 1 167 ? -32.228 -50.658 21.759  1.00 11.61 ?  390  GLN A C   1 
ATOM   1278 O O   . GLN A 1 167 ? -32.812 -49.950 20.926  1.00 11.83 ?  390  GLN A O   1 
ATOM   1279 C CB  . GLN A 1 167 ? -32.517 -49.743 24.140  1.00 10.03 ?  390  GLN A CB  1 
ATOM   1280 C CG  . GLN A 1 167 ? -33.218 -50.962 24.750  1.00 12.77 ?  390  GLN A CG  1 
ATOM   1281 C CD  . GLN A 1 167 ? -34.674 -51.125 24.229  1.00 11.61 ?  390  GLN A CD  1 
ATOM   1282 O OE1 . GLN A 1 167 ? -35.089 -50.485 23.251  1.00 11.73 ?  390  GLN A OE1 1 
ATOM   1283 N NE2 . GLN A 1 167 ? -35.438 -52.066 24.869  1.00 12.21 ?  390  GLN A NE2 1 
ATOM   1284 N N   . ASP A 1 168 ? -32.110 -51.989 21.627  1.00 11.08 ?  391  ASP A N   1 
ATOM   1285 C CA  . ASP A 1 168 ? -32.571 -52.711 20.438  1.00 11.84 ?  391  ASP A CA  1 
ATOM   1286 C C   . ASP A 1 168 ? -33.700 -53.680 20.754  1.00 15.51 ?  391  ASP A C   1 
ATOM   1287 O O   . ASP A 1 168 ? -34.002 -54.548 19.923  1.00 15.30 ?  391  ASP A O   1 
ATOM   1288 C CB  . ASP A 1 168 ? -31.421 -53.465 19.765  1.00 14.16 ?  391  ASP A CB  1 
ATOM   1289 C CG  . ASP A 1 168 ? -30.463 -52.511 19.093  1.00 15.69 ?  391  ASP A CG  1 
ATOM   1290 O OD1 . ASP A 1 168 ? -30.920 -51.817 18.160  1.00 16.03 ?  391  ASP A OD1 1 
ATOM   1291 O OD2 . ASP A 1 168 ? -29.281 -52.472 19.527  1.00 15.45 ?  391  ASP A OD2 1 
ATOM   1292 N N   . GLY A 1 169 ? -34.327 -53.536 21.910  1.00 13.71 ?  392  GLY A N   1 
ATOM   1293 C CA  . GLY A 1 169 ? -35.476 -54.349 22.260  1.00 13.29 ?  392  GLY A CA  1 
ATOM   1294 C C   . GLY A 1 169 ? -35.189 -55.297 23.415  1.00 14.85 ?  392  GLY A C   1 
ATOM   1295 O O   . GLY A 1 169 ? -34.045 -55.518 23.827  1.00 15.29 ?  392  GLY A O   1 
ATOM   1296 N N   . GLY A 1 170 ? -36.279 -55.891 23.905  1.00 13.38 ?  393  GLY A N   1 
ATOM   1297 C CA  . GLY A 1 170 ? -36.166 -56.936 24.913  1.00 15.41 ?  393  GLY A CA  1 
ATOM   1298 C C   . GLY A 1 170 ? -37.541 -57.242 25.470  1.00 15.83 ?  393  GLY A C   1 
ATOM   1299 O O   . GLY A 1 170 ? -38.556 -56.867 24.877  1.00 16.61 ?  393  GLY A O   1 
ATOM   1300 N N   . THR A 1 171 ? -37.556 -57.914 26.634  1.00 17.59 ?  394  THR A N   1 
ATOM   1301 C CA  . THR A 1 171 ? -38.853 -58.207 27.251  1.00 16.31 ?  394  THR A CA  1 
ATOM   1302 C C   . THR A 1 171 ? -39.531 -56.942 27.756  1.00 17.55 ?  394  THR A C   1 
ATOM   1303 O O   . THR A 1 171 ? -40.760 -56.924 27.877  1.00 18.54 ?  394  THR A O   1 
ATOM   1304 C CB  . THR A 1 171 ? -38.681 -59.183 28.403  1.00 19.05 ?  394  THR A CB  1 
ATOM   1305 O OG1 . THR A 1 171 ? -37.793 -58.597 29.374  1.00 16.34 ?  394  THR A OG1 1 
ATOM   1306 C CG2 . THR A 1 171 ? -38.118 -60.533 27.881  1.00 18.33 ?  394  THR A CG2 1 
ATOM   1307 N N   . THR A 1 172 ? -38.763 -55.880 28.013  1.00 15.78 ?  395  THR A N   1 
ATOM   1308 C CA  . THR A 1 172 ? -39.278 -54.598 28.488  1.00 15.74 ?  395  THR A CA  1 
ATOM   1309 C C   . THR A 1 172 ? -38.445 -53.469 27.876  1.00 15.97 ?  395  THR A C   1 
ATOM   1310 O O   . THR A 1 172 ? -37.295 -53.671 27.448  1.00 14.96 ?  395  THR A O   1 
ATOM   1311 C CB  . THR A 1 172 ? -39.223 -54.429 30.025  1.00 19.43 ?  395  THR A CB  1 
ATOM   1312 O OG1 . THR A 1 172 ? -37.855 -54.239 30.458  1.00 22.02 ?  395  THR A OG1 1 
ATOM   1313 C CG2 . THR A 1 172 ? -39.812 -55.635 30.762  1.00 23.87 ?  395  THR A CG2 1 
ATOM   1314 N N   . HIS A 1 173 ? -39.043 -52.289 27.862  1.00 16.90 ?  396  HIS A N   1 
ATOM   1315 C CA  . HIS A 1 173 ? -38.248 -51.076 27.637  1.00 14.36 ?  396  HIS A CA  1 
ATOM   1316 C C   . HIS A 1 173 ? -37.213 -50.914 28.755  1.00 14.33 ?  396  HIS A C   1 
ATOM   1317 O O   . HIS A 1 173 ? -37.349 -51.434 29.871  1.00 13.58 ?  396  HIS A O   1 
ATOM   1318 C CB  . HIS A 1 173 ? -39.142 -49.828 27.601  1.00 13.91 ?  396  HIS A CB  1 
ATOM   1319 C CG  . HIS A 1 173 ? -40.170 -49.809 26.504  1.00 14.53 ?  396  HIS A CG  1 
ATOM   1320 N ND1 . HIS A 1 173 ? -40.023 -50.456 25.296  1.00 15.22 ?  396  HIS A ND1 1 
ATOM   1321 C CD2 . HIS A 1 173 ? -41.347 -49.142 26.425  1.00 16.01 ?  396  HIS A CD2 1 
ATOM   1322 C CE1 . HIS A 1 173 ? -41.075 -50.204 24.522  1.00 13.83 ?  396  HIS A CE1 1 
ATOM   1323 N NE2 . HIS A 1 173 ? -41.875 -49.384 25.175  1.00 17.89 ?  396  HIS A NE2 1 
ATOM   1324 N N   . ARG A 1 174 ? -36.144 -50.141 28.449  1.00 12.37 ?  397  ARG A N   1 
ATOM   1325 C CA  . ARG A 1 174 ? -35.177 -49.720 29.466  1.00 11.62 ?  397  ARG A CA  1 
ATOM   1326 C C   . ARG A 1 174 ? -34.437 -50.909 30.095  1.00 10.63 ?  397  ARG A C   1 
ATOM   1327 O O   . ARG A 1 174 ? -33.948 -50.790 31.216  1.00 11.14 ?  397  ARG A O   1 
ATOM   1328 C CB  . ARG A 1 174 ? -35.837 -48.867 30.561  1.00 13.49 ?  397  ARG A CB  1 
ATOM   1329 C CG  . ARG A 1 174 ? -36.494 -47.602 30.013  1.00 13.80 ?  397  ARG A CG  1 
ATOM   1330 C CD  . ARG A 1 174 ? -37.116 -46.663 31.087  1.00 15.73 ?  397  ARG A CD  1 
ATOM   1331 N NE  . ARG A 1 174 ? -36.117 -46.128 32.034  1.00 19.80 ?  397  ARG A NE  1 
ATOM   1332 C CZ  . ARG A 1 174 ? -36.005 -46.491 33.306  1.00 22.95 ?  397  ARG A CZ  1 
ATOM   1333 N NH1 . ARG A 1 174 ? -36.798 -47.424 33.835  1.00 24.46 ?  397  ARG A NH1 1 
ATOM   1334 N NH2 . ARG A 1 174 ? -35.071 -45.906 34.074  1.00 21.18 ?  397  ARG A NH2 1 
ATOM   1335 N N   . ASN A 1 175 ? -34.283 -52.006 29.345  1.00 11.33 ?  398  ASN A N   1 
ATOM   1336 C CA  . ASN A 1 175 ? -33.522 -53.161 29.799  1.00 13.29 ?  398  ASN A CA  1 
ATOM   1337 C C   . ASN A 1 175 ? -32.014 -53.012 29.595  1.00 12.64 ?  398  ASN A C   1 
ATOM   1338 O O   . ASN A 1 175 ? -31.250 -53.819 30.142  1.00 14.00 ?  398  ASN A O   1 
ATOM   1339 C CB  . ASN A 1 175 ? -34.033 -54.428 29.093  1.00 12.64 ?  398  ASN A CB  1 
ATOM   1340 C CG  . ASN A 1 175 ? -33.863 -54.398 27.568  1.00 15.02 ?  398  ASN A CG  1 
ATOM   1341 O OD1 . ASN A 1 175 ? -33.923 -53.320 26.947  1.00 12.39 ?  398  ASN A OD1 1 
ATOM   1342 N ND2 . ASN A 1 175 ? -33.690 -55.596 26.940  1.00 14.72 ?  398  ASN A ND2 1 
ATOM   1343 N N   . GLU A 1 176 ? -31.572 -51.958 28.894  1.00 10.16 ?  399  GLU A N   1 
ATOM   1344 C CA  . GLU A 1 176 ? -30.165 -51.651 28.663  1.00 11.76 ?  399  GLU A CA  1 
ATOM   1345 C C   . GLU A 1 176 ? -30.090 -50.165 28.409  1.00 10.72 ?  399  GLU A C   1 
ATOM   1346 O O   . GLU A 1 176 ? -31.071 -49.602 27.938  1.00 10.27 ?  399  GLU A O   1 
ATOM   1347 C CB  . GLU A 1 176 ? -29.593 -52.404 27.449  1.00 11.70 ?  399  GLU A CB  1 
ATOM   1348 C CG  . GLU A 1 176 ? -30.369 -52.244 26.126  1.00 11.73 ?  399  GLU A CG  1 
ATOM   1349 C CD  . GLU A 1 176 ? -29.620 -52.757 24.895  1.00 11.66 ?  399  GLU A CD  1 
ATOM   1350 O OE1 . GLU A 1 176 ? -28.387 -52.928 24.919  1.00 13.63 ?  399  GLU A OE1 1 
ATOM   1351 O OE2 . GLU A 1 176 ? -30.286 -52.993 23.873  1.00 12.70 ?  399  GLU A OE2 1 
ATOM   1352 N N   . PRO A 1 177 ? -28.940 -49.512 28.657  1.00 8.99  ?  400  PRO A N   1 
ATOM   1353 C CA  . PRO A 1 177 ? -27.735 -50.013 29.338  1.00 8.99  ?  400  PRO A CA  1 
ATOM   1354 C C   . PRO A 1 177 ? -28.014 -50.531 30.748  1.00 9.52  ?  400  PRO A C   1 
ATOM   1355 O O   . PRO A 1 177 ? -29.088 -50.272 31.301  1.00 10.88 ?  400  PRO A O   1 
ATOM   1356 C CB  . PRO A 1 177 ? -26.848 -48.752 29.446  1.00 11.54 ?  400  PRO A CB  1 
ATOM   1357 C CG  . PRO A 1 177 ? -27.247 -47.913 28.301  1.00 12.95 ?  400  PRO A CG  1 
ATOM   1358 C CD  . PRO A 1 177 ? -28.778 -48.107 28.212  1.00 9.98  ?  400  PRO A CD  1 
ATOM   1359 N N   . GLN A 1 178 ? -27.004 -51.179 31.316  1.00 9.48  ?  401  GLN A N   1 
ATOM   1360 C CA  . GLN A 1 178 ? -27.021 -51.703 32.683  1.00 13.14 ?  401  GLN A CA  1 
ATOM   1361 C C   . GLN A 1 178 ? -25.909 -50.944 33.411  1.00 9.09  ?  401  GLN A C   1 
ATOM   1362 O O   . GLN A 1 178 ? -24.732 -51.330 33.371  1.00 9.23  ?  401  GLN A O   1 
ATOM   1363 C CB  . GLN A 1 178 ? -26.779 -53.221 32.681  1.00 12.18 ?  401  GLN A CB  1 
ATOM   1364 C CG  . GLN A 1 178 ? -28.052 -54.010 32.290  1.00 13.85 ?  401  GLN A CG  1 
ATOM   1365 C CD  . GLN A 1 178 ? -28.177 -55.301 33.075  1.00 27.98 ?  401  GLN A CD  1 
ATOM   1366 O OE1 . GLN A 1 178 ? -27.686 -56.378 32.663  1.00 30.58 ?  401  GLN A OE1 1 
ATOM   1367 N NE2 . GLN A 1 178 ? -28.826 -55.200 34.235  1.00 30.97 ?  401  GLN A NE2 1 
ATOM   1368 N N   . GLN A 1 179 ? -26.253 -49.801 34.005  1.00 8.98  ?  402  GLN A N   1 
ATOM   1369 C CA  . GLN A 1 179 ? -25.209 -48.890 34.460  1.00 9.38  ?  402  GLN A CA  1 
ATOM   1370 C C   . GLN A 1 179 ? -24.389 -49.439 35.617  1.00 11.21 ?  402  GLN A C   1 
ATOM   1371 O O   . GLN A 1 179 ? -23.292 -48.919 35.871  1.00 10.68 ?  402  GLN A O   1 
ATOM   1372 C CB  . GLN A 1 179 ? -25.791 -47.525 34.866  1.00 10.04 ?  402  GLN A CB  1 
ATOM   1373 C CG  . GLN A 1 179 ? -26.630 -47.530 36.197  1.00 8.71  ?  402  GLN A CG  1 
ATOM   1374 C CD  . GLN A 1 179 ? -26.785 -46.118 36.785  1.00 9.77  ?  402  GLN A CD  1 
ATOM   1375 O OE1 . GLN A 1 179 ? -25.815 -45.298 36.797  1.00 11.46 ?  402  GLN A OE1 1 
ATOM   1376 N NE2 . GLN A 1 179 ? -27.989 -45.828 37.309  1.00 10.98 ?  402  GLN A NE2 1 
ATOM   1377 N N   . TRP A 1 180 ? -24.889 -50.458 36.328  1.00 9.75  ?  403  TRP A N   1 
ATOM   1378 C CA  . TRP A 1 180 ? -24.135 -51.002 37.455  1.00 10.66 ?  403  TRP A CA  1 
ATOM   1379 C C   . TRP A 1 180 ? -23.457 -52.325 37.122  1.00 12.81 ?  403  TRP A C   1 
ATOM   1380 O O   . TRP A 1 180 ? -22.937 -52.991 38.039  1.00 14.66 ?  403  TRP A O   1 
ATOM   1381 C CB  . TRP A 1 180 ? -25.069 -51.174 38.669  1.00 11.20 ?  403  TRP A CB  1 
ATOM   1382 C CG  . TRP A 1 180 ? -25.651 -49.857 39.179  1.00 9.86  ?  403  TRP A CG  1 
ATOM   1383 C CD1 . TRP A 1 180 ? -26.977 -49.549 39.328  1.00 11.79 ?  403  TRP A CD1 1 
ATOM   1384 C CD2 . TRP A 1 180 ? -24.924 -48.666 39.547  1.00 11.07 ?  403  TRP A CD2 1 
ATOM   1385 N NE1 . TRP A 1 180 ? -27.128 -48.253 39.796  1.00 14.13 ?  403  TRP A NE1 1 
ATOM   1386 C CE2 . TRP A 1 180 ? -25.887 -47.699 39.965  1.00 11.20 ?  403  TRP A CE2 1 
ATOM   1387 C CE3 . TRP A 1 180 ? -23.560 -48.325 39.617  1.00 10.00 ?  403  TRP A CE3 1 
ATOM   1388 C CZ2 . TRP A 1 180 ? -25.524 -46.410 40.403  1.00 11.83 ?  403  TRP A CZ2 1 
ATOM   1389 C CZ3 . TRP A 1 180 ? -23.197 -47.026 40.056  1.00 10.66 ?  403  TRP A CZ3 1 
ATOM   1390 C CH2 . TRP A 1 180 ? -24.190 -46.088 40.430  1.00 10.93 ?  403  TRP A CH2 1 
ATOM   1391 N N   . VAL A 1 181 ? -23.451 -52.731 35.856  1.00 10.75 ?  404  VAL A N   1 
ATOM   1392 C CA  . VAL A 1 181 ? -22.742 -53.929 35.431  1.00 12.51 ?  404  VAL A CA  1 
ATOM   1393 C C   . VAL A 1 181 ? -21.435 -53.503 34.763  1.00 11.19 ?  404  VAL A C   1 
ATOM   1394 O O   . VAL A 1 181 ? -21.446 -52.923 33.666  1.00 11.76 ?  404  VAL A O   1 
ATOM   1395 C CB  . VAL A 1 181 ? -23.598 -54.786 34.493  1.00 13.80 ?  404  VAL A CB  1 
ATOM   1396 C CG1 . VAL A 1 181 ? -22.796 -56.036 33.961  1.00 13.20 ?  404  VAL A CG1 1 
ATOM   1397 C CG2 . VAL A 1 181 ? -24.888 -55.226 35.222  1.00 11.43 ?  404  VAL A CG2 1 
ATOM   1398 N N   . LEU A 1 182 ? -20.293 -53.845 35.378  1.00 10.33 ?  405  LEU A N   1 
ATOM   1399 C CA  . LEU A 1 182 ? -19.013 -53.512 34.748  1.00 9.69  ?  405  LEU A CA  1 
ATOM   1400 C C   . LEU A 1 182 ? -18.787 -54.358 33.500  1.00 10.74 ?  405  LEU A C   1 
ATOM   1401 O O   . LEU A 1 182 ? -19.130 -55.560 33.465  1.00 11.92 ?  405  LEU A O   1 
ATOM   1402 C CB  . LEU A 1 182 ? -17.851 -53.760 35.733  1.00 10.86 ?  405  LEU A CB  1 
ATOM   1403 C CG  . LEU A 1 182 ? -17.717 -52.822 36.915  1.00 11.71 ?  405  LEU A CG  1 
ATOM   1404 C CD1 . LEU A 1 182 ? -16.582 -53.365 37.804  1.00 13.08 ?  405  LEU A CD1 1 
ATOM   1405 C CD2 . LEU A 1 182 ? -17.438 -51.377 36.393  1.00 11.66 ?  405  LEU A CD2 1 
ATOM   1406 N N   . PRO A 1 183 ? -18.152 -53.789 32.481  1.00 10.81 ?  406  PRO A N   1 
ATOM   1407 C CA  . PRO A 1 183 ? -17.705 -54.603 31.343  1.00 10.55 ?  406  PRO A CA  1 
ATOM   1408 C C   . PRO A 1 183 ? -16.586 -55.544 31.767  1.00 10.50 ?  406  PRO A C   1 
ATOM   1409 O O   . PRO A 1 183 ? -15.982 -55.362 32.821  1.00 10.84 ?  406  PRO A O   1 
ATOM   1410 C CB  . PRO A 1 183 ? -17.159 -53.591 30.318  1.00 11.14 ?  406  PRO A CB  1 
ATOM   1411 C CG  . PRO A 1 183 ? -17.493 -52.208 30.863  1.00 11.60 ?  406  PRO A CG  1 
ATOM   1412 C CD  . PRO A 1 183 ? -17.706 -52.385 32.389  1.00 10.64 ?  406  PRO A CD  1 
ATOM   1413 N N   . SER A 1 184 ? -16.315 -56.531 30.899  1.00 9.69  ?  407  SER A N   1 
ATOM   1414 C CA  . SER A 1 184 ? -15.099 -57.346 30.996  1.00 11.27 ?  407  SER A CA  1 
ATOM   1415 C C   . SER A 1 184 ? -14.030 -56.621 30.202  1.00 10.34 ?  407  SER A C   1 
ATOM   1416 O O   . SER A 1 184 ? -14.022 -56.675 28.972  1.00 10.78 ?  407  SER A O   1 
ATOM   1417 C CB  . SER A 1 184 ? -15.319 -58.736 30.408  1.00 10.77 ?  407  SER A CB  1 
ATOM   1418 O OG  . SER A 1 184 ? -15.904 -59.563 31.387  1.00 21.41 ?  407  SER A OG  1 
ATOM   1419 N N   . TYR A 1 185 ? -13.137 -55.929 30.899  1.00 9.65  ?  408  TYR A N   1 
ATOM   1420 C CA  . TYR A 1 185 ? -12.241 -54.997 30.208  1.00 9.29  ?  408  TYR A CA  1 
ATOM   1421 C C   . TYR A 1 185 ? -11.240 -55.665 29.265  1.00 10.32 ?  408  TYR A C   1 
ATOM   1422 O O   . TYR A 1 185 ? -10.698 -54.971 28.388  1.00 9.81  ?  408  TYR A O   1 
ATOM   1423 C CB  . TYR A 1 185 ? -11.466 -54.135 31.215  1.00 10.74 ?  408  TYR A CB  1 
ATOM   1424 C CG  . TYR A 1 185 ? -12.315 -53.100 31.973  1.00 11.69 ?  408  TYR A CG  1 
ATOM   1425 C CD1 . TYR A 1 185 ? -12.961 -52.033 31.300  1.00 9.96  ?  408  TYR A CD1 1 
ATOM   1426 C CD2 . TYR A 1 185 ? -12.512 -53.213 33.368  1.00 9.05  ?  408  TYR A CD2 1 
ATOM   1427 C CE1 . TYR A 1 185 ? -13.739 -51.126 32.034  1.00 9.20  ?  408  TYR A CE1 1 
ATOM   1428 C CE2 . TYR A 1 185 ? -13.253 -52.300 34.088  1.00 10.13 ?  408  TYR A CE2 1 
ATOM   1429 C CZ  . TYR A 1 185 ? -13.862 -51.244 33.396  1.00 9.74  ?  408  TYR A CZ  1 
ATOM   1430 O OH  . TYR A 1 185 ? -14.605 -50.323 34.140  1.00 9.72  ?  408  TYR A OH  1 
ATOM   1431 N N   . SER A 1 186 ? -10.904 -56.959 29.459  1.00 10.12 ?  409  SER A N   1 
ATOM   1432 C CA  . SER A 1 186 ? -10.017 -57.643 28.520  1.00 9.84  ?  409  SER A CA  1 
ATOM   1433 C C   . SER A 1 186 ? -10.778 -58.622 27.620  1.00 10.66 ?  409  SER A C   1 
ATOM   1434 O O   . SER A 1 186 ? -10.165 -59.531 27.029  1.00 12.18 ?  409  SER A O   1 
ATOM   1435 C CB  . SER A 1 186 ? -8.888  -58.359 29.289  1.00 9.14  ?  409  SER A CB  1 
ATOM   1436 O OG  . SER A 1 186 ? -7.979  -57.411 29.780  1.00 10.89 ?  409  SER A OG  1 
ATOM   1437 N N   . GLY A 1 187 ? -12.101 -58.434 27.454  1.00 11.41 ?  410  GLY A N   1 
ATOM   1438 C CA  . GLY A 1 187 ? -12.921 -59.331 26.632  1.00 10.50 ?  410  GLY A CA  1 
ATOM   1439 C C   . GLY A 1 187 ? -13.504 -60.524 27.381  1.00 11.24 ?  410  GLY A C   1 
ATOM   1440 O O   . GLY A 1 187 ? -13.371 -60.672 28.597  1.00 11.66 ?  410  GLY A O   1 
ATOM   1441 N N   . ARG A 1 188 ? -14.244 -61.358 26.631  1.00 11.30 ?  411  ARG A N   1 
ATOM   1442 C CA  . ARG A 1 188 ? -14.973 -62.475 27.233  1.00 12.61 ?  411  ARG A CA  1 
ATOM   1443 C C   . ARG A 1 188 ? -14.045 -63.383 28.042  1.00 13.86 ?  411  ARG A C   1 
ATOM   1444 O O   . ARG A 1 188 ? -12.902 -63.627 27.641  1.00 15.47 ?  411  ARG A O   1 
ATOM   1445 C CB  . ARG A 1 188 ? -15.670 -63.293 26.129  1.00 15.80 ?  411  ARG A CB  1 
ATOM   1446 C CG  . ARG A 1 188 ? -16.575 -64.393 26.608  1.00 20.85 ?  411  ARG A CG  1 
ATOM   1447 C CD  . ARG A 1 188 ? -17.156 -65.255 25.435  1.00 31.37 ?  411  ARG A CD  1 
ATOM   1448 N NE  . ARG A 1 188 ? -16.246 -66.301 24.961  1.00 38.57 ?  411  ARG A NE  1 
ATOM   1449 C CZ  . ARG A 1 188 ? -15.342 -66.154 23.997  1.00 44.05 ?  411  ARG A CZ  1 
ATOM   1450 N NH1 . ARG A 1 188 ? -15.295 -65.057 23.245  1.00 38.43 ?  411  ARG A NH1 1 
ATOM   1451 N NH2 . ARG A 1 188 ? -14.483 -67.148 23.755  1.00 42.25 ?  411  ARG A NH2 1 
ATOM   1452 N N   . ASN A 1 189 ? -14.536 -63.825 29.208  1.00 13.77 ?  412  ASN A N   1 
ATOM   1453 C CA  A ASN A 1 189 ? -13.859 -64.820 30.060  0.50 15.00 ?  412  ASN A CA  1 
ATOM   1454 C CA  B ASN A 1 189 ? -13.808 -64.850 29.985  0.50 15.00 ?  412  ASN A CA  1 
ATOM   1455 C C   . ASN A 1 189 ? -12.466 -64.343 30.495  1.00 14.81 ?  412  ASN A C   1 
ATOM   1456 O O   . ASN A 1 189 ? -11.442 -65.014 30.322  1.00 15.34 ?  412  ASN A O   1 
ATOM   1457 C CB  A ASN A 1 189 ? -13.811 -66.173 29.351  0.50 15.95 ?  412  ASN A CB  1 
ATOM   1458 C CB  B ASN A 1 189 ? -13.550 -66.116 29.148  0.50 15.95 ?  412  ASN A CB  1 
ATOM   1459 C CG  A ASN A 1 189 ? -13.521 -67.298 30.307  0.50 14.73 ?  412  ASN A CG  1 
ATOM   1460 C CG  B ASN A 1 189 ? -14.780 -66.792 28.670  0.50 14.73 ?  412  ASN A CG  1 
ATOM   1461 O OD1 A ASN A 1 189 ? -14.158 -67.423 31.339  0.50 15.98 ?  412  ASN A OD1 1 
ATOM   1462 O OD1 B ASN A 1 189 ? -15.728 -66.993 29.422  0.50 15.98 ?  412  ASN A OD1 1 
ATOM   1463 N ND2 A ASN A 1 189 ? -12.515 -68.087 29.992  0.50 15.94 ?  412  ASN A ND2 1 
ATOM   1464 N ND2 B ASN A 1 189 ? -14.781 -67.161 27.394  0.50 15.94 ?  412  ASN A ND2 1 
ATOM   1465 N N   . THR A 1 190 ? -12.432 -63.139 31.068  1.00 11.90 ?  413  THR A N   1 
ATOM   1466 C CA  . THR A 1 190 ? -11.188 -62.599 31.611  1.00 12.05 ?  413  THR A CA  1 
ATOM   1467 C C   . THR A 1 190 ? -11.426 -61.970 32.976  1.00 10.16 ?  413  THR A C   1 
ATOM   1468 O O   . THR A 1 190 ? -12.550 -61.586 33.318  1.00 13.89 ?  413  THR A O   1 
ATOM   1469 C CB  . THR A 1 190 ? -10.530 -61.531 30.690  1.00 13.13 ?  413  THR A CB  1 
ATOM   1470 O OG1 . THR A 1 190 ? -11.487 -60.475 30.485  1.00 12.50 ?  413  THR A OG1 1 
ATOM   1471 C CG2 . THR A 1 190 ? -10.139 -62.124 29.339  1.00 10.98 ?  413  THR A CG2 1 
ATOM   1472 N N   . HIS A 1 191 ? -10.328 -61.823 33.737  1.00 9.78  ?  414  HIS A N   1 
ATOM   1473 C CA  . HIS A 1 191 ? -10.332 -61.200 35.061  1.00 11.89 ?  414  HIS A CA  1 
ATOM   1474 C C   . HIS A 1 191 ? -10.157 -59.683 34.942  1.00 8.73  ?  414  HIS A C   1 
ATOM   1475 O O   . HIS A 1 191 ? -9.111  -59.231 34.469  1.00 11.93 ?  414  HIS A O   1 
ATOM   1476 C CB  . HIS A 1 191 ? -9.144  -61.703 35.899  1.00 12.09 ?  414  HIS A CB  1 
ATOM   1477 C CG  . HIS A 1 191 ? -9.227  -63.155 36.287  1.00 13.19 ?  414  HIS A CG  1 
ATOM   1478 N ND1 . HIS A 1 191 ? -9.924  -63.574 37.393  1.00 15.01 ?  414  HIS A ND1 1 
ATOM   1479 C CD2 . HIS A 1 191 ? -8.658  -64.266 35.743  1.00 12.99 ?  414  HIS A CD2 1 
ATOM   1480 C CE1 . HIS A 1 191 ? -9.799  -64.897 37.507  1.00 14.48 ?  414  HIS A CE1 1 
ATOM   1481 N NE2 . HIS A 1 191 ? -9.062  -65.339 36.499  1.00 11.92 ?  414  HIS A NE2 1 
ATOM   1482 N N   . ASN A 1 192 ? -11.110 -58.909 35.473  1.00 11.34 ?  415  ASN A N   1 
ATOM   1483 C CA  . ASN A 1 192 ? -10.852 -57.471 35.675  1.00 10.78 ?  415  ASN A CA  1 
ATOM   1484 C C   . ASN A 1 192 ? -9.824  -57.289 36.800  1.00 13.14 ?  415  ASN A C   1 
ATOM   1485 O O   . ASN A 1 192 ? -9.772  -58.086 37.757  1.00 14.64 ?  415  ASN A O   1 
ATOM   1486 C CB  . ASN A 1 192 ? -12.154 -56.725 36.048  1.00 11.89 ?  415  ASN A CB  1 
ATOM   1487 C CG  . ASN A 1 192 ? -13.081 -56.493 34.845  1.00 10.32 ?  415  ASN A CG  1 
ATOM   1488 O OD1 . ASN A 1 192 ? -12.660 -56.575 33.693  1.00 10.64 ?  415  ASN A OD1 1 
ATOM   1489 N ND2 . ASN A 1 192 ? -14.351 -56.146 35.128  1.00 10.22 ?  415  ASN A ND2 1 
ATOM   1490 N N   . VAL A 1 193 ? -8.978  -56.245 36.673  1.00 11.06 ?  416  VAL A N   1 
ATOM   1491 C CA  . VAL A 1 193 ? -7.909  -55.999 37.645  1.00 10.20 ?  416  VAL A CA  1 
ATOM   1492 C C   . VAL A 1 193 ? -7.891  -54.560 38.138  1.00 14.86 ?  416  VAL A C   1 
ATOM   1493 O O   . VAL A 1 193 ? -8.397  -53.643 37.483  1.00 10.53 ?  416  VAL A O   1 
ATOM   1494 C CB  . VAL A 1 193 ? -6.511  -56.366 37.068  1.00 12.79 ?  416  VAL A CB  1 
ATOM   1495 C CG1 . VAL A 1 193 ? -6.497  -57.889 36.814  1.00 14.97 ?  416  VAL A CG1 1 
ATOM   1496 C CG2 . VAL A 1 193 ? -6.225  -55.607 35.762  1.00 13.51 ?  416  VAL A CG2 1 
ATOM   1497 N N   . HIS A 1 194 ? -7.355  -54.375 39.343  1.00 12.21 ?  417  HIS A N   1 
ATOM   1498 C CA  . HIS A 1 194 ? -7.082  -53.029 39.879  1.00 13.82 ?  417  HIS A CA  1 
ATOM   1499 C C   . HIS A 1 194 ? -8.339  -52.167 39.999  1.00 12.10 ?  417  HIS A C   1 
ATOM   1500 O O   . HIS A 1 194 ? -8.244  -50.942 39.889  1.00 13.07 ?  417  HIS A O   1 
ATOM   1501 C CB  . HIS A 1 194 ? -6.015  -52.309 39.041  1.00 12.77 ?  417  HIS A CB  1 
ATOM   1502 C CG  . HIS A 1 194 ? -4.740  -53.099 38.903  1.00 15.66 ?  417  HIS A CG  1 
ATOM   1503 N ND1 . HIS A 1 194 ? -3.981  -53.480 39.990  1.00 20.59 ?  417  HIS A ND1 1 
ATOM   1504 C CD2 . HIS A 1 194 ? -4.122  -53.607 37.810  1.00 18.55 ?  417  HIS A CD2 1 
ATOM   1505 C CE1 . HIS A 1 194 ? -2.939  -54.185 39.567  1.00 18.63 ?  417  HIS A CE1 1 
ATOM   1506 N NE2 . HIS A 1 194 ? -2.999  -54.275 38.249  1.00 19.83 ?  417  HIS A NE2 1 
ATOM   1507 N N   . LEU A 1 195 ? -9.474  -52.787 40.309  1.00 12.57 ?  418  LEU A N   1 
ATOM   1508 C CA  . LEU A 1 195 ? -10.742 -52.061 40.400  1.00 11.05 ?  418  LEU A CA  1 
ATOM   1509 C C   . LEU A 1 195 ? -10.796 -51.206 41.661  1.00 14.55 ?  418  LEU A C   1 
ATOM   1510 O O   . LEU A 1 195 ? -10.354 -51.616 42.739  1.00 14.16 ?  418  LEU A O   1 
ATOM   1511 C CB  . LEU A 1 195 ? -11.921 -53.042 40.429  1.00 12.09 ?  418  LEU A CB  1 
ATOM   1512 C CG  . LEU A 1 195 ? -12.109 -53.935 39.213  1.00 11.06 ?  418  LEU A CG  1 
ATOM   1513 C CD1 . LEU A 1 195 ? -13.264 -54.903 39.421  1.00 12.48 ?  418  LEU A CD1 1 
ATOM   1514 C CD2 . LEU A 1 195 ? -12.378 -53.040 37.981  1.00 11.32 ?  418  LEU A CD2 1 
ATOM   1515 N N   . ALA A 1 196 ? -11.398 -50.018 41.541  1.00 11.76 ?  419  ALA A N   1 
ATOM   1516 C CA  . ALA A 1 196 ? -11.905 -49.339 42.730  1.00 12.84 ?  419  ALA A CA  1 
ATOM   1517 C C   . ALA A 1 196 ? -12.976 -50.205 43.387  1.00 10.94 ?  419  ALA A C   1 
ATOM   1518 O O   . ALA A 1 196 ? -13.755 -50.858 42.693  1.00 12.79 ?  419  ALA A O   1 
ATOM   1519 C CB  . ALA A 1 196 ? -12.511 -47.973 42.330  1.00 12.24 ?  419  ALA A CB  1 
ATOM   1520 N N   . PRO A 1 197 ? -13.076 -50.223 44.716  1.00 13.09 ?  420  PRO A N   1 
ATOM   1521 C CA  . PRO A 1 197 ? -13.963 -51.206 45.360  1.00 14.42 ?  420  PRO A CA  1 
ATOM   1522 C C   . PRO A 1 197 ? -15.435 -50.865 45.211  1.00 15.15 ?  420  PRO A C   1 
ATOM   1523 O O   . PRO A 1 197 ? -15.833 -49.715 44.973  1.00 13.96 ?  420  PRO A O   1 
ATOM   1524 C CB  . PRO A 1 197 ? -13.551 -51.157 46.838  1.00 15.73 ?  420  PRO A CB  1 
ATOM   1525 C CG  . PRO A 1 197 ? -12.934 -49.845 47.015  1.00 16.95 ?  420  PRO A CG  1 
ATOM   1526 C CD  . PRO A 1 197 ? -12.292 -49.435 45.678  1.00 15.92 ?  420  PRO A CD  1 
ATOM   1527 N N   . ALA A 1 198 ? -16.265 -51.893 45.389  1.00 15.28 ?  421  ALA A N   1 
ATOM   1528 C CA  . ALA A 1 198 ? -17.692 -51.673 45.515  1.00 13.05 ?  421  ALA A CA  1 
ATOM   1529 C C   . ALA A 1 198 ? -17.992 -50.832 46.754  1.00 15.38 ?  421  ALA A C   1 
ATOM   1530 O O   . ALA A 1 198 ? -17.261 -50.888 47.748  1.00 16.44 ?  421  ALA A O   1 
ATOM   1531 C CB  . ALA A 1 198 ? -18.432 -53.007 45.592  1.00 16.24 ?  421  ALA A CB  1 
ATOM   1532 N N   . VAL A 1 199 ? -19.101 -50.077 46.704  1.00 13.98 ?  422  VAL A N   1 
ATOM   1533 C CA  . VAL A 1 199 ? -19.512 -49.209 47.805  1.00 14.88 ?  422  VAL A CA  1 
ATOM   1534 C C   . VAL A 1 199 ? -20.924 -49.588 48.243  1.00 18.42 ?  422  VAL A C   1 
ATOM   1535 O O   . VAL A 1 199 ? -21.772 -50.007 47.439  1.00 14.41 ?  422  VAL A O   1 
ATOM   1536 C CB  . VAL A 1 199 ? -19.425 -47.680 47.510  1.00 17.21 ?  422  VAL A CB  1 
ATOM   1537 C CG1 . VAL A 1 199 ? -18.007 -47.313 47.004  1.00 15.68 ?  422  VAL A CG1 1 
ATOM   1538 C CG2 . VAL A 1 199 ? -20.457 -47.237 46.536  1.00 18.30 ?  422  VAL A CG2 1 
ATOM   1539 N N   . ALA A 1 200 ? -21.164 -49.443 49.556  1.00 18.22 ?  423  ALA A N   1 
ATOM   1540 C CA  . ALA A 1 200 ? -22.478 -49.693 50.139  1.00 20.17 ?  423  ALA A CA  1 
ATOM   1541 C C   . ALA A 1 200 ? -22.620 -48.906 51.428  1.00 21.07 ?  423  ALA A C   1 
ATOM   1542 O O   . ALA A 1 200 ? -21.627 -48.679 52.123  1.00 22.76 ?  423  ALA A O   1 
ATOM   1543 C CB  . ALA A 1 200 ? -22.674 -51.183 50.419  1.00 22.28 ?  423  ALA A CB  1 
ATOM   1544 N N   . PRO A 1 201 ? -23.817 -48.440 51.756  1.00 22.19 ?  424  PRO A N   1 
ATOM   1545 C CA  . PRO A 1 201 ? -23.999 -47.832 53.082  1.00 20.86 ?  424  PRO A CA  1 
ATOM   1546 C C   . PRO A 1 201 ? -23.764 -48.913 54.140  1.00 26.07 ?  424  PRO A C   1 
ATOM   1547 O O   . PRO A 1 201 ? -24.164 -50.061 53.965  1.00 25.91 ?  424  PRO A O   1 
ATOM   1548 C CB  . PRO A 1 201 ? -25.455 -47.349 53.053  1.00 22.52 ?  424  PRO A CB  1 
ATOM   1549 C CG  . PRO A 1 201 ? -26.146 -48.238 51.989  1.00 26.22 ?  424  PRO A CG  1 
ATOM   1550 C CD  . PRO A 1 201 ? -25.072 -48.555 50.983  1.00 23.08 ?  424  PRO A CD  1 
ATOM   1551 N N   . THR A 1 202 ? -23.045 -48.555 55.201  1.00 27.43 ?  425  THR A N   1 
ATOM   1552 C CA  . THR A 1 202 ? -22.806 -49.446 56.332  1.00 29.02 ?  425  THR A CA  1 
ATOM   1553 C C   . THR A 1 202 ? -23.575 -49.052 57.587  1.00 31.95 ?  425  THR A C   1 
ATOM   1554 O O   . THR A 1 202 ? -23.664 -49.855 58.525  1.00 32.55 ?  425  THR A O   1 
ATOM   1555 C CB  . THR A 1 202 ? -21.306 -49.479 56.659  1.00 32.23 ?  425  THR A CB  1 
ATOM   1556 O OG1 . THR A 1 202 ? -20.875 -48.153 57.008  1.00 34.08 ?  425  THR A OG1 1 
ATOM   1557 C CG2 . THR A 1 202 ? -20.500 -49.996 55.467  1.00 31.45 ?  425  THR A CG2 1 
ATOM   1558 N N   . PHE A 1 203 ? -24.143 -47.870 57.628  1.00 26.08 ?  426  PHE A N   1 
ATOM   1559 C CA  . PHE A 1 203 ? -24.789 -47.341 58.817  1.00 27.28 ?  426  PHE A CA  1 
ATOM   1560 C C   . PHE A 1 203 ? -26.287 -47.567 58.741  1.00 28.30 ?  426  PHE A C   1 
ATOM   1561 O O   . PHE A 1 203 ? -26.903 -47.334 57.696  1.00 26.44 ?  426  PHE A O   1 
ATOM   1562 C CB  . PHE A 1 203 ? -24.482 -45.849 58.949  1.00 25.58 ?  426  PHE A CB  1 
ATOM   1563 C CG  . PHE A 1 203 ? -24.718 -45.267 60.323  1.00 28.41 ?  426  PHE A CG  1 
ATOM   1564 C CD1 . PHE A 1 203 ? -25.960 -44.769 60.680  1.00 29.14 ?  426  PHE A CD1 1 
ATOM   1565 C CD2 . PHE A 1 203 ? -23.678 -45.185 61.244  1.00 32.53 ?  426  PHE A CD2 1 
ATOM   1566 C CE1 . PHE A 1 203 ? -26.172 -44.193 61.942  1.00 32.03 ?  426  PHE A CE1 1 
ATOM   1567 C CE2 . PHE A 1 203 ? -23.881 -44.615 62.509  1.00 33.39 ?  426  PHE A CE2 1 
ATOM   1568 C CZ  . PHE A 1 203 ? -25.133 -44.131 62.860  1.00 31.31 ?  426  PHE A CZ  1 
ATOM   1569 N N   . PRO A 1 204 ? -26.938 -48.027 59.805  1.00 28.93 ?  427  PRO A N   1 
ATOM   1570 C CA  . PRO A 1 204 ? -28.370 -48.345 59.693  1.00 26.52 ?  427  PRO A CA  1 
ATOM   1571 C C   . PRO A 1 204 ? -29.209 -47.128 59.295  1.00 22.87 ?  427  PRO A C   1 
ATOM   1572 O O   . PRO A 1 204 ? -28.999 -46.011 59.777  1.00 24.09 ?  427  PRO A O   1 
ATOM   1573 C CB  . PRO A 1 204 ? -28.733 -48.860 61.099  1.00 30.28 ?  427  PRO A CB  1 
ATOM   1574 C CG  . PRO A 1 204 ? -27.602 -48.508 61.987  1.00 29.67 ?  427  PRO A CG  1 
ATOM   1575 C CD  . PRO A 1 204 ? -26.383 -48.296 61.145  1.00 31.13 ?  427  PRO A CD  1 
ATOM   1576 N N   . GLY A 1 205 ? -30.158 -47.358 58.385  1.00 22.65 ?  428  GLY A N   1 
ATOM   1577 C CA  . GLY A 1 205 ? -31.042 -46.326 57.884  1.00 21.86 ?  428  GLY A CA  1 
ATOM   1578 C C   . GLY A 1 205 ? -30.456 -45.460 56.775  1.00 22.38 ?  428  GLY A C   1 
ATOM   1579 O O   . GLY A 1 205 ? -31.138 -44.537 56.311  1.00 20.40 ?  428  GLY A O   1 
ATOM   1580 N N   . GLU A 1 206 ? -29.222 -45.725 56.338  1.00 21.77 ?  429  GLU A N   1 
ATOM   1581 C CA  . GLU A 1 206 ? -28.594 -44.876 55.322  1.00 19.82 ?  429  GLU A CA  1 
ATOM   1582 C C   . GLU A 1 206 ? -28.689 -45.510 53.936  1.00 19.72 ?  429  GLU A C   1 
ATOM   1583 O O   . GLU A 1 206 ? -28.783 -46.727 53.789  1.00 18.60 ?  429  GLU A O   1 
ATOM   1584 C CB  . GLU A 1 206 ? -27.123 -44.598 55.659  1.00 18.52 ?  429  GLU A CB  1 
ATOM   1585 C CG  . GLU A 1 206 ? -27.005 -43.642 56.848  1.00 19.25 ?  429  GLU A CG  1 
ATOM   1586 C CD  . GLU A 1 206 ? -25.617 -43.121 57.131  1.00 21.46 ?  429  GLU A CD  1 
ATOM   1587 O OE1 . GLU A 1 206 ? -24.669 -43.354 56.332  1.00 21.14 ?  429  GLU A OE1 1 
ATOM   1588 O OE2 . GLU A 1 206 ? -25.466 -42.427 58.164  1.00 21.89 -1 429  GLU A OE2 1 
ATOM   1589 N N   . GLN A 1 207 ? -28.667 -44.645 52.918  1.00 15.67 ?  430  GLN A N   1 
ATOM   1590 C CA  . GLN A 1 207 ? -28.621 -45.032 51.503  1.00 15.00 ?  430  GLN A CA  1 
ATOM   1591 C C   . GLN A 1 207 ? -27.548 -44.177 50.834  1.00 14.55 ?  430  GLN A C   1 
ATOM   1592 O O   . GLN A 1 207 ? -27.208 -43.096 51.322  1.00 14.00 ?  430  GLN A O   1 
ATOM   1593 C CB  . GLN A 1 207 ? -29.960 -44.789 50.775  1.00 15.44 ?  430  GLN A CB  1 
ATOM   1594 C CG  . GLN A 1 207 ? -31.050 -45.785 51.171  1.00 15.59 ?  430  GLN A CG  1 
ATOM   1595 C CD  . GLN A 1 207 ? -32.397 -45.574 50.531  1.00 17.71 ?  430  GLN A CD  1 
ATOM   1596 O OE1 . GLN A 1 207 ? -33.250 -46.449 50.669  1.00 18.86 ?  430  GLN A OE1 1 
ATOM   1597 N NE2 . GLN A 1 207 ? -32.627 -44.439 49.840  1.00 16.05 ?  430  GLN A NE2 1 
ATOM   1598 N N   . LEU A 1 208 ? -27.031 -44.659 49.707  1.00 13.22 ?  431  LEU A N   1 
ATOM   1599 C CA  . LEU A 1 208 ? -26.150 -43.816 48.898  1.00 14.21 ?  431  LEU A CA  1 
ATOM   1600 C C   . LEU A 1 208 ? -26.924 -42.604 48.387  1.00 11.29 ?  431  LEU A C   1 
ATOM   1601 O O   . LEU A 1 208 ? -28.119 -42.703 48.099  1.00 11.67 ?  431  LEU A O   1 
ATOM   1602 C CB  . LEU A 1 208 ? -25.637 -44.620 47.713  1.00 12.89 ?  431  LEU A CB  1 
ATOM   1603 C CG  . LEU A 1 208 ? -24.688 -45.748 48.090  1.00 13.46 ?  431  LEU A CG  1 
ATOM   1604 C CD1 . LEU A 1 208 ? -24.354 -46.656 46.904  1.00 14.11 ?  431  LEU A CD1 1 
ATOM   1605 C CD2 . LEU A 1 208 ? -23.421 -45.186 48.654  1.00 15.90 ?  431  LEU A CD2 1 
ATOM   1606 N N   . LEU A 1 209 ? -26.227 -41.458 48.253  1.00 10.65 ?  432  LEU A N   1 
ATOM   1607 C CA  . LEU A 1 209 ? -26.730 -40.298 47.511  1.00 10.54 ?  432  LEU A CA  1 
ATOM   1608 C C   . LEU A 1 209 ? -26.046 -40.253 46.149  1.00 11.56 ?  432  LEU A C   1 
ATOM   1609 O O   . LEU A 1 209 ? -24.812 -40.244 46.085  1.00 12.09 ?  432  LEU A O   1 
ATOM   1610 C CB  . LEU A 1 209 ? -26.445 -39.000 48.247  1.00 12.15 ?  432  LEU A CB  1 
ATOM   1611 C CG  . LEU A 1 209 ? -27.101 -37.744 47.603  1.00 11.77 ?  432  LEU A CG  1 
ATOM   1612 C CD1 . LEU A 1 209 ? -28.658 -37.810 47.597  1.00 14.58 ?  432  LEU A CD1 1 
ATOM   1613 C CD2 . LEU A 1 209 ? -26.609 -36.454 48.305  1.00 12.14 ?  432  LEU A CD2 1 
ATOM   1614 N N   . PHE A 1 210 ? -26.842 -40.227 45.083  1.00 10.90 ?  433  PHE A N   1 
ATOM   1615 C CA  . PHE A 1 210 ? -26.316 -40.315 43.718  1.00 11.02 ?  433  PHE A CA  1 
ATOM   1616 C C   . PHE A 1 210 ? -26.435 -38.954 43.055  1.00 11.06 ?  433  PHE A C   1 
ATOM   1617 O O   . PHE A 1 210 ? -27.445 -38.255 43.225  1.00 11.50 ?  433  PHE A O   1 
ATOM   1618 C CB  . PHE A 1 210 ? -27.075 -41.335 42.868  1.00 11.05 ?  433  PHE A CB  1 
ATOM   1619 C CG  . PHE A 1 210 ? -26.976 -42.743 43.383  1.00 11.98 ?  433  PHE A CG  1 
ATOM   1620 C CD1 . PHE A 1 210 ? -25.805 -43.452 43.222  1.00 11.89 ?  433  PHE A CD1 1 
ATOM   1621 C CD2 . PHE A 1 210 ? -28.030 -43.324 44.103  1.00 14.22 ?  433  PHE A CD2 1 
ATOM   1622 C CE1 . PHE A 1 210 ? -25.683 -44.771 43.694  1.00 13.73 ?  433  PHE A CE1 1 
ATOM   1623 C CE2 . PHE A 1 210 ? -27.904 -44.650 44.602  1.00 14.45 ?  433  PHE A CE2 1 
ATOM   1624 C CZ  . PHE A 1 210 ? -26.722 -45.356 44.366  1.00 14.27 ?  433  PHE A CZ  1 
ATOM   1625 N N   . PHE A 1 211 ? -25.409 -38.605 42.248  1.00 9.38  ?  434  PHE A N   1 
ATOM   1626 C CA  . PHE A 1 211 ? -25.394 -37.388 41.429  1.00 7.79  ?  434  PHE A CA  1 
ATOM   1627 C C   . PHE A 1 211 ? -25.809 -37.825 40.029  1.00 9.54  ?  434  PHE A C   1 
ATOM   1628 O O   . PHE A 1 211 ? -25.096 -38.615 39.384  1.00 9.89  ?  434  PHE A O   1 
ATOM   1629 C CB  . PHE A 1 211 ? -24.003 -36.756 41.461  1.00 7.92  ?  434  PHE A CB  1 
ATOM   1630 C CG  . PHE A 1 211 ? -23.576 -36.318 42.845  1.00 8.95  ?  434  PHE A CG  1 
ATOM   1631 C CD1 . PHE A 1 211 ? -22.960 -37.238 43.708  1.00 11.14 ?  434  PHE A CD1 1 
ATOM   1632 C CD2 . PHE A 1 211 ? -23.847 -35.016 43.300  1.00 10.48 ?  434  PHE A CD2 1 
ATOM   1633 C CE1 . PHE A 1 211 ? -22.572 -36.847 44.996  1.00 9.54  ?  434  PHE A CE1 1 
ATOM   1634 C CE2 . PHE A 1 211 ? -23.449 -34.622 44.582  1.00 10.38 ?  434  PHE A CE2 1 
ATOM   1635 C CZ  . PHE A 1 211 ? -22.842 -35.531 45.439  1.00 10.66 ?  434  PHE A CZ  1 
ATOM   1636 N N   . ARG A 1 212 ? -27.020 -37.437 39.619  1.00 8.66  ?  435  ARG A N   1 
ATOM   1637 C CA  . ARG A 1 212 ? -27.710 -38.079 38.498  1.00 8.41  ?  435  ARG A CA  1 
ATOM   1638 C C   . ARG A 1 212 ? -27.828 -37.190 37.252  1.00 9.53  ?  435  ARG A C   1 
ATOM   1639 O O   . ARG A 1 212 ? -28.109 -35.988 37.330  1.00 9.29  ?  435  ARG A O   1 
ATOM   1640 C CB  . ARG A 1 212 ? -29.133 -38.532 38.940  1.00 9.68  ?  435  ARG A CB  1 
ATOM   1641 C CG  . ARG A 1 212 ? -29.989 -39.092 37.822  1.00 8.46  ?  435  ARG A CG  1 
ATOM   1642 C CD  . ARG A 1 212 ? -31.248 -39.799 38.350  1.00 13.47 ?  435  ARG A CD  1 
ATOM   1643 N NE  . ARG A 1 212 ? -30.903 -41.123 38.863  1.00 10.67 ?  435  ARG A NE  1 
ATOM   1644 C CZ  . ARG A 1 212 ? -31.785 -42.099 39.020  1.00 13.80 ?  435  ARG A CZ  1 
ATOM   1645 N NH1 . ARG A 1 212 ? -33.088 -41.887 38.857  1.00 15.50 ?  435  ARG A NH1 1 
ATOM   1646 N NH2 . ARG A 1 212 ? -31.353 -43.320 39.316  1.00 14.15 ?  435  ARG A NH2 1 
ATOM   1647 N N   . SER A 1 213 ? -27.634 -37.814 36.088  1.00 9.35  ?  436  SER A N   1 
ATOM   1648 C CA  . SER A 1 213 ? -27.873 -37.227 34.767  1.00 8.80  ?  436  SER A CA  1 
ATOM   1649 C C   . SER A 1 213 ? -28.731 -38.161 33.943  1.00 9.34  ?  436  SER A C   1 
ATOM   1650 O O   . SER A 1 213 ? -28.920 -39.338 34.271  1.00 9.39  ?  436  SER A O   1 
ATOM   1651 C CB  . SER A 1 213 ? -26.537 -36.990 34.012  1.00 8.18  ?  436  SER A CB  1 
ATOM   1652 O OG  . SER A 1 213 ? -25.674 -36.162 34.772  1.00 8.37  ?  436  SER A OG  1 
ATOM   1653 N N   . THR A 1 214 ? -29.172 -37.652 32.788  1.00 8.88  ?  437  THR A N   1 
ATOM   1654 C CA  . THR A 1 214 ? -29.902 -38.435 31.792  1.00 8.96  ?  437  THR A CA  1 
ATOM   1655 C C   . THR A 1 214 ? -29.067 -38.450 30.510  1.00 9.76  ?  437  THR A C   1 
ATOM   1656 O O   . THR A 1 214 ? -28.816 -37.393 29.898  1.00 10.55 ?  437  THR A O   1 
ATOM   1657 C CB  . THR A 1 214 ? -31.305 -37.824 31.508  1.00 12.06 ?  437  THR A CB  1 
ATOM   1658 O OG1 . THR A 1 214 ? -31.994 -37.581 32.734  1.00 11.69 ?  437  THR A OG1 1 
ATOM   1659 C CG2 . THR A 1 214 ? -32.110 -38.786 30.624  1.00 13.92 ?  437  THR A CG2 1 
ATOM   1660 N N   . MET A 1 215 ? -28.601 -39.632 30.108  1.00 9.64  ?  438  MET A N   1 
ATOM   1661 C CA  . MET A 1 215 ? -27.717 -39.766 28.947  1.00 8.97  ?  438  MET A CA  1 
ATOM   1662 C C   . MET A 1 215 ? -28.615 -39.547 27.722  1.00 9.83  ?  438  MET A C   1 
ATOM   1663 O O   . MET A 1 215 ? -29.766 -40.007 27.709  1.00 9.45  ?  438  MET A O   1 
ATOM   1664 C CB  . MET A 1 215 ? -27.247 -41.215 28.984  1.00 8.65  ?  438  MET A CB  1 
ATOM   1665 C CG  . MET A 1 215 ? -26.028 -41.364 29.824  1.00 9.76  ?  438  MET A CG  1 
ATOM   1666 S SD  . MET A 1 215 ? -25.293 -42.989 29.751  1.00 10.44 ?  438  MET A SD  1 
ATOM   1667 C CE  . MET A 1 215 ? -26.601 -44.025 30.439  1.00 10.92 ?  438  MET A CE  1 
ATOM   1668 N N   . PRO A 1 216 ? -28.166 -38.837 26.689  1.00 7.85  ?  439  PRO A N   1 
ATOM   1669 C CA  . PRO A 1 216 ? -28.967 -38.820 25.452  1.00 7.49  ?  439  PRO A CA  1 
ATOM   1670 C C   . PRO A 1 216 ? -29.225 -40.237 24.965  1.00 7.42  ?  439  PRO A C   1 
ATOM   1671 O O   . PRO A 1 216 ? -28.382 -41.139 25.090  1.00 8.85  ?  439  PRO A O   1 
ATOM   1672 C CB  . PRO A 1 216 ? -28.100 -38.016 24.460  1.00 7.54  ?  439  PRO A CB  1 
ATOM   1673 C CG  . PRO A 1 216 ? -27.257 -37.161 25.334  1.00 9.33  ?  439  PRO A CG  1 
ATOM   1674 C CD  . PRO A 1 216 ? -26.981 -37.958 26.604  1.00 9.93  ?  439  PRO A CD  1 
ATOM   1675 N N   . GLY A 1 217 ? -30.407 -40.429 24.383  1.00 8.65  ?  440  GLY A N   1 
ATOM   1676 C CA  . GLY A 1 217 ? -30.737 -41.659 23.694  1.00 7.83  ?  440  GLY A CA  1 
ATOM   1677 C C   . GLY A 1 217 ? -30.750 -41.459 22.186  1.00 9.03  ?  440  GLY A C   1 
ATOM   1678 O O   . GLY A 1 217 ? -31.342 -40.494 21.681  1.00 8.63  ?  440  GLY A O   1 
ATOM   1679 N N   . CYS A 1 218 ? -30.146 -42.393 21.455  1.00 8.34  ?  441  CYS A N   1 
ATOM   1680 C CA  . CYS A 1 218 ? -30.029 -42.271 19.999  1.00 8.48  ?  441  CYS A CA  1 
ATOM   1681 C C   . CYS A 1 218 ? -30.916 -43.209 19.196  1.00 9.66  ?  441  CYS A C   1 
ATOM   1682 O O   . CYS A 1 218 ? -30.980 -43.066 17.958  1.00 9.22  ?  441  CYS A O   1 
ATOM   1683 C CB  . CYS A 1 218 ? -28.566 -42.511 19.562  1.00 9.20  ?  441  CYS A CB  1 
ATOM   1684 S SG  . CYS A 1 218 ? -27.351 -41.366 20.352  1.00 11.91 ?  441  CYS A SG  1 
ATOM   1685 N N   . SER A 1 219 ? -31.529 -44.218 19.841  1.00 10.08 ?  442  SER A N   1 
ATOM   1686 C CA  . SER A 1 219 ? -32.488 -45.111 19.186  1.00 9.84  ?  442  SER A CA  1 
ATOM   1687 C C   . SER A 1 219 ? -33.040 -46.110 20.204  1.00 10.38 ?  442  SER A C   1 
ATOM   1688 O O   . SER A 1 219 ? -32.386 -46.397 21.220  1.00 10.14 ?  442  SER A O   1 
ATOM   1689 C CB  . SER A 1 219 ? -31.898 -45.820 17.973  1.00 12.54 ?  442  SER A CB  1 
ATOM   1690 O OG  . SER A 1 219 ? -30.976 -46.872 18.313  1.00 17.11 ?  442  SER A OG  1 
ATOM   1691 N N   . GLY A 1 220 ? -34.268 -46.570 19.976  1.00 10.39 ?  443  GLY A N   1 
ATOM   1692 C CA  . GLY A 1 220 ? -34.872 -47.516 20.909  1.00 11.81 ?  443  GLY A CA  1 
ATOM   1693 C C   . GLY A 1 220 ? -35.381 -46.859 22.188  1.00 10.95 ?  443  GLY A C   1 
ATOM   1694 O O   . GLY A 1 220 ? -35.701 -45.639 22.256  1.00 9.62  ?  443  GLY A O   1 
ATOM   1695 N N   . TYR A 1 221 ? -35.526 -47.696 23.214  1.00 10.43 ?  444  TYR A N   1 
ATOM   1696 C CA  . TYR A 1 221 ? -36.073 -47.283 24.509  1.00 10.63 ?  444  TYR A CA  1 
ATOM   1697 C C   . TYR A 1 221 ? -35.042 -47.537 25.598  1.00 10.69 ?  444  TYR A C   1 
ATOM   1698 O O   . TYR A 1 221 ? -35.245 -48.357 26.511  1.00 11.41 ?  444  TYR A O   1 
ATOM   1699 C CB  . TYR A 1 221 ? -37.375 -48.019 24.833  1.00 12.13 ?  444  TYR A CB  1 
ATOM   1700 C CG  . TYR A 1 221 ? -38.435 -47.914 23.739  1.00 10.99 ?  444  TYR A CG  1 
ATOM   1701 C CD1 . TYR A 1 221 ? -38.364 -48.719 22.610  1.00 12.37 ?  444  TYR A CD1 1 
ATOM   1702 C CD2 . TYR A 1 221 ? -39.474 -47.026 23.868  1.00 11.73 ?  444  TYR A CD2 1 
ATOM   1703 C CE1 . TYR A 1 221 ? -39.341 -48.635 21.600  1.00 14.83 ?  444  TYR A CE1 1 
ATOM   1704 C CE2 . TYR A 1 221 ? -40.480 -46.946 22.870  1.00 11.57 ?  444  TYR A CE2 1 
ATOM   1705 C CZ  . TYR A 1 221 ? -40.390 -47.763 21.764  1.00 15.26 ?  444  TYR A CZ  1 
ATOM   1706 O OH  . TYR A 1 221 ? -41.377 -47.671 20.764  1.00 19.68 ?  444  TYR A OH  1 
ATOM   1707 N N   . PRO A 1 222 ? -33.913 -46.850 25.547  1.00 10.00 ?  445  PRO A N   1 
ATOM   1708 C CA  . PRO A 1 222 ? -32.851 -47.139 26.506  1.00 10.08 ?  445  PRO A CA  1 
ATOM   1709 C C   . PRO A 1 222 ? -33.159 -46.629 27.901  1.00 9.59  ?  445  PRO A C   1 
ATOM   1710 O O   . PRO A 1 222 ? -33.902 -45.674 28.115  1.00 10.18 ?  445  PRO A O   1 
ATOM   1711 C CB  . PRO A 1 222 ? -31.637 -46.397 25.922  1.00 9.69  ?  445  PRO A CB  1 
ATOM   1712 C CG  . PRO A 1 222 ? -32.239 -45.207 25.223  1.00 10.33 ?  445  PRO A CG  1 
ATOM   1713 C CD  . PRO A 1 222 ? -33.548 -45.774 24.606  1.00 10.92 ?  445  PRO A CD  1 
ATOM   1714 N N   . ASN A 1 223 ? -32.504 -47.254 28.880  1.00 9.62  ?  446  ASN A N   1 
ATOM   1715 C CA  . ASN A 1 223 ? -32.466 -46.701 30.230  1.00 9.24  ?  446  ASN A CA  1 
ATOM   1716 C C   . ASN A 1 223 ? -31.375 -45.643 30.266  1.00 9.34  ?  446  ASN A C   1 
ATOM   1717 O O   . ASN A 1 223 ? -30.183 -45.974 30.185  1.00 10.66 ?  446  ASN A O   1 
ATOM   1718 C CB  . ASN A 1 223 ? -32.169 -47.765 31.285  1.00 11.33 ?  446  ASN A CB  1 
ATOM   1719 C CG  . ASN A 1 223 ? -32.248 -47.208 32.702  1.00 12.55 ?  446  ASN A CG  1 
ATOM   1720 O OD1 . ASN A 1 223 ? -32.335 -45.991 32.918  1.00 12.36 ?  446  ASN A OD1 1 
ATOM   1721 N ND2 . ASN A 1 223 ? -32.254 -48.102 33.696  1.00 13.73 ?  446  ASN A ND2 1 
ATOM   1722 N N   . MET A 1 224 ? -31.776 -44.387 30.364  1.00 9.42  ?  447  MET A N   1 
ATOM   1723 C CA  . MET A 1 224 ? -30.841 -43.288 30.201  1.00 9.06  ?  447  MET A CA  1 
ATOM   1724 C C   . MET A 1 224 ? -30.358 -42.753 31.570  1.00 11.12 ?  447  MET A C   1 
ATOM   1725 O O   . MET A 1 224 ? -29.554 -41.807 31.629  1.00 10.76 ?  447  MET A O   1 
ATOM   1726 C CB  . MET A 1 224 ? -31.562 -42.210 29.380  1.00 10.31 ?  447  MET A CB  1 
ATOM   1727 C CG  . MET A 1 224 ? -31.387 -42.393 27.873  1.00 11.84 ?  447  MET A CG  1 
ATOM   1728 S SD  . MET A 1 224 ? -32.665 -41.503 26.876  1.00 11.09 ?  447  MET A SD  1 
ATOM   1729 C CE  . MET A 1 224 ? -34.309 -42.140 27.410  1.00 11.50 ?  447  MET A CE  1 
ATOM   1730 N N   . ASP A 1 225 ? -30.805 -43.341 32.694  1.00 11.99 ?  448  ASP A N   1 
ATOM   1731 C CA  . ASP A 1 225 ? -30.342 -42.881 34.005  1.00 10.54 ?  448  ASP A CA  1 
ATOM   1732 C C   . ASP A 1 225 ? -28.853 -43.121 34.171  1.00 10.02 ?  448  ASP A C   1 
ATOM   1733 O O   . ASP A 1 225 ? -28.375 -44.206 33.880  1.00 10.73 ?  448  ASP A O   1 
ATOM   1734 C CB  . ASP A 1 225 ? -31.071 -43.609 35.138  1.00 12.13 ?  448  ASP A CB  1 
ATOM   1735 C CG  . ASP A 1 225 ? -32.554 -43.223 35.216  1.00 14.65 ?  448  ASP A CG  1 
ATOM   1736 O OD1 . ASP A 1 225 ? -32.902 -42.103 34.812  1.00 14.72 ?  448  ASP A OD1 1 
ATOM   1737 O OD2 . ASP A 1 225 ? -33.345 -44.074 35.686  1.00 15.26 -1 448  ASP A OD2 1 
ATOM   1738 N N   . LEU A 1 226 ? -28.117 -42.119 34.669  1.00 9.47  ?  449  LEU A N   1 
ATOM   1739 C CA  . LEU A 1 226 ? -26.694 -42.351 34.934  1.00 10.03 ?  449  LEU A CA  1 
ATOM   1740 C C   . LEU A 1 226 ? -26.325 -41.673 36.245  1.00 8.57  ?  449  LEU A C   1 
ATOM   1741 O O   . LEU A 1 226 ? -26.333 -40.436 36.367  1.00 9.87  ?  449  LEU A O   1 
ATOM   1742 C CB  . LEU A 1 226 ? -25.814 -41.847 33.782  1.00 9.29  ?  449  LEU A CB  1 
ATOM   1743 C CG  . LEU A 1 226 ? -24.313 -42.145 33.981  1.00 9.93  ?  449  LEU A CG  1 
ATOM   1744 C CD1 . LEU A 1 226 ? -24.043 -43.624 33.787  1.00 10.99 ?  449  LEU A CD1 1 
ATOM   1745 C CD2 . LEU A 1 226 ? -23.492 -41.307 32.935  1.00 11.26 ?  449  LEU A CD2 1 
ATOM   1746 N N   . ASP A 1 227 ? -25.968 -42.490 37.233  1.00 9.30  ?  450  ASP A N   1 
ATOM   1747 C CA  . ASP A 1 227 ? -25.649 -42.038 38.583  1.00 9.33  ?  450  ASP A CA  1 
ATOM   1748 C C   . ASP A 1 227 ? -24.148 -42.124 38.831  1.00 9.80  ?  450  ASP A C   1 
ATOM   1749 O O   . ASP A 1 227 ? -23.547 -43.190 38.615  1.00 11.13 ?  450  ASP A O   1 
ATOM   1750 C CB  . ASP A 1 227 ? -26.375 -42.944 39.594  1.00 8.53  ?  450  ASP A CB  1 
ATOM   1751 C CG  . ASP A 1 227 ? -27.871 -42.792 39.524  1.00 10.63 ?  450  ASP A CG  1 
ATOM   1752 O OD1 . ASP A 1 227 ? -28.292 -41.630 39.602  1.00 12.67 ?  450  ASP A OD1 1 
ATOM   1753 O OD2 . ASP A 1 227 ? -28.568 -43.832 39.424  1.00 13.63 -1 450  ASP A OD2 1 
ATOM   1754 N N   . CYS A 1 228 ? -23.553 -41.030 39.306  1.00 8.29  ?  451  CYS A N   1 
ATOM   1755 C CA  . CYS A 1 228 ? -22.154 -41.102 39.720  1.00 8.87  ?  451  CYS A CA  1 
ATOM   1756 C C   . CYS A 1 228 ? -22.051 -40.832 41.224  1.00 9.67  ?  451  CYS A C   1 
ATOM   1757 O O   . CYS A 1 228 ? -22.942 -40.230 41.825  1.00 9.84  ?  451  CYS A O   1 
ATOM   1758 C CB  . CYS A 1 228 ? -21.245 -40.138 38.894  1.00 8.42  ?  451  CYS A CB  1 
ATOM   1759 S SG  . CYS A 1 228 ? -21.608 -38.350 39.067  1.00 9.40  ?  451  CYS A SG  1 
ATOM   1760 N N   . LEU A 1 229 ? -20.962 -41.305 41.833  1.00 9.39  ?  452  LEU A N   1 
ATOM   1761 C CA  . LEU A 1 229 ? -20.792 -41.181 43.278  1.00 8.72  ?  452  LEU A CA  1 
ATOM   1762 C C   . LEU A 1 229 ? -20.233 -39.824 43.685  1.00 9.21  ?  452  LEU A C   1 
ATOM   1763 O O   . LEU A 1 229 ? -20.414 -39.400 44.835  1.00 11.46 ?  452  LEU A O   1 
ATOM   1764 C CB  . LEU A 1 229 ? -19.836 -42.271 43.800  1.00 9.36  ?  452  LEU A CB  1 
ATOM   1765 C CG  . LEU A 1 229 ? -20.255 -43.685 43.462  1.00 10.63 ?  452  LEU A CG  1 
ATOM   1766 C CD1 . LEU A 1 229 ? -19.225 -44.707 43.998  1.00 12.11 ?  452  LEU A CD1 1 
ATOM   1767 C CD2 . LEU A 1 229 ? -21.672 -44.011 44.013  1.00 11.89 ?  452  LEU A CD2 1 
ATOM   1768 N N   . LEU A 1 230 ? -19.520 -39.144 42.773  1.00 8.41  ?  453  LEU A N   1 
ATOM   1769 C CA  . LEU A 1 230 ? -18.926 -37.824 42.984  1.00 8.69  ?  453  LEU A CA  1 
ATOM   1770 C C   . LEU A 1 230 ? -19.085 -37.023 41.695  1.00 8.75  ?  453  LEU A C   1 
ATOM   1771 O O   . LEU A 1 230 ? -18.782 -37.567 40.617  1.00 9.21  ?  453  LEU A O   1 
ATOM   1772 C CB  . LEU A 1 230 ? -17.419 -37.918 43.272  1.00 8.82  ?  453  LEU A CB  1 
ATOM   1773 C CG  . LEU A 1 230 ? -16.986 -38.723 44.512  1.00 9.46  ?  453  LEU A CG  1 
ATOM   1774 C CD1 . LEU A 1 230 ? -15.480 -38.965 44.502  1.00 12.90 ?  453  LEU A CD1 1 
ATOM   1775 C CD2 . LEU A 1 230 ? -17.470 -37.995 45.758  1.00 11.66 ?  453  LEU A CD2 1 
ATOM   1776 N N   . PRO A 1 231 ? -19.461 -35.741 41.756  1.00 9.06  ?  454  PRO A N   1 
ATOM   1777 C CA  . PRO A 1 231 ? -19.341 -34.904 40.555  1.00 9.39  ?  454  PRO A CA  1 
ATOM   1778 C C   . PRO A 1 231 ? -17.905 -34.878 40.057  1.00 8.18  ?  454  PRO A C   1 
ATOM   1779 O O   . PRO A 1 231 ? -16.939 -34.936 40.815  1.00 7.40  ?  454  PRO A O   1 
ATOM   1780 C CB  . PRO A 1 231 ? -19.765 -33.506 41.020  1.00 8.97  ?  454  PRO A CB  1 
ATOM   1781 C CG  . PRO A 1 231 ? -20.516 -33.696 42.358  1.00 9.68  ?  454  PRO A CG  1 
ATOM   1782 C CD  . PRO A 1 231 ? -19.831 -34.966 42.962  1.00 9.23  ?  454  PRO A CD  1 
ATOM   1783 N N   . GLN A 1 232 ? -17.764 -34.698 38.754  1.00 7.82  ?  455  GLN A N   1 
ATOM   1784 C CA  . GLN A 1 232 ? -16.410 -34.611 38.196  1.00 7.24  ?  455  GLN A CA  1 
ATOM   1785 C C   . GLN A 1 232 ? -15.637 -33.452 38.830  1.00 8.02  ?  455  GLN A C   1 
ATOM   1786 O O   . GLN A 1 232 ? -14.429 -33.578 39.080  1.00 8.95  ?  455  GLN A O   1 
ATOM   1787 C CB  . GLN A 1 232 ? -16.461 -34.452 36.656  1.00 7.95  ?  455  GLN A CB  1 
ATOM   1788 C CG  . GLN A 1 232 ? -15.038 -34.461 36.041  1.00 6.85  ?  455  GLN A CG  1 
ATOM   1789 C CD  . GLN A 1 232 ? -14.316 -35.797 36.231  1.00 9.84  ?  455  GLN A CD  1 
ATOM   1790 O OE1 . GLN A 1 232 ? -14.924 -36.857 36.457  1.00 9.21  ?  455  GLN A OE1 1 
ATOM   1791 N NE2 . GLN A 1 232 ? -12.976 -35.736 36.124  1.00 9.35  ?  455  GLN A NE2 1 
ATOM   1792 N N   . GLU A 1 233 ? -16.331 -32.346 39.168  1.00 7.84  ?  456  GLU A N   1 
ATOM   1793 C CA  . GLU A 1 233 ? -15.659 -31.189 39.754  1.00 7.85  ?  456  GLU A CA  1 
ATOM   1794 C C   . GLU A 1 233 ? -15.153 -31.510 41.170  1.00 8.86  ?  456  GLU A C   1 
ATOM   1795 O O   . GLU A 1 233 ? -14.175 -30.892 41.647  1.00 9.63  ?  456  GLU A O   1 
ATOM   1796 C CB  . GLU A 1 233 ? -16.604 -29.984 39.802  1.00 8.72  ?  456  GLU A CB  1 
ATOM   1797 C CG  . GLU A 1 233 ? -16.796 -29.328 38.420  1.00 8.93  ?  456  GLU A CG  1 
ATOM   1798 C CD  . GLU A 1 233 ? -17.770 -30.076 37.507  1.00 8.59  ?  456  GLU A CD  1 
ATOM   1799 O OE1 . GLU A 1 233 ? -18.405 -31.069 37.934  1.00 8.32  ?  456  GLU A OE1 1 
ATOM   1800 O OE2 . GLU A 1 233 ? -17.891 -29.626 36.341  1.00 9.56  -1 456  GLU A OE2 1 
ATOM   1801 N N   . TRP A 1 234 ? -15.815 -32.440 41.854  1.00 8.22  ?  457  TRP A N   1 
ATOM   1802 C CA  . TRP A 1 234 ? -15.287 -32.846 43.163  1.00 10.06 ?  457  TRP A CA  1 
ATOM   1803 C C   . TRP A 1 234 ? -14.019 -33.678 43.018  1.00 9.62  ?  457  TRP A C   1 
ATOM   1804 O O   . TRP A 1 234 ? -13.069 -33.491 43.787  1.00 9.44  ?  457  TRP A O   1 
ATOM   1805 C CB  . TRP A 1 234 ? -16.317 -33.628 43.988  1.00 9.39  ?  457  TRP A CB  1 
ATOM   1806 C CG  . TRP A 1 234 ? -17.485 -32.722 44.503  1.00 10.15 ?  457  TRP A CG  1 
ATOM   1807 C CD1 . TRP A 1 234 ? -17.872 -31.479 44.029  1.00 9.86  ?  457  TRP A CD1 1 
ATOM   1808 C CD2 . TRP A 1 234 ? -18.341 -33.014 45.604  1.00 11.60 ?  457  TRP A CD2 1 
ATOM   1809 N NE1 . TRP A 1 234 ? -18.949 -31.013 44.760  1.00 10.62 ?  457  TRP A NE1 1 
ATOM   1810 C CE2 . TRP A 1 234 ? -19.259 -31.941 45.728  1.00 11.65 ?  457  TRP A CE2 1 
ATOM   1811 C CE3 . TRP A 1 234 ? -18.453 -34.105 46.477  1.00 11.59 ?  457  TRP A CE3 1 
ATOM   1812 C CZ2 . TRP A 1 234 ? -20.266 -31.927 46.698  1.00 11.88 ?  457  TRP A CZ2 1 
ATOM   1813 C CZ3 . TRP A 1 234 ? -19.452 -34.071 47.448  1.00 11.38 ?  457  TRP A CZ3 1 
ATOM   1814 C CH2 . TRP A 1 234 ? -20.344 -33.012 47.536  1.00 11.30 ?  457  TRP A CH2 1 
ATOM   1815 N N   . VAL A 1 235 ? -13.975 -34.599 42.055  1.00 9.50  ?  458  VAL A N   1 
ATOM   1816 C CA  . VAL A 1 235 ? -12.713 -35.274 41.718  1.00 8.06  ?  458  VAL A CA  1 
ATOM   1817 C C   . VAL A 1 235 ? -11.618 -34.235 41.433  1.00 10.46 ?  458  VAL A C   1 
ATOM   1818 O O   . VAL A 1 235 ? -10.492 -34.325 41.946  1.00 9.80  ?  458  VAL A O   1 
ATOM   1819 C CB  . VAL A 1 235 ? -12.909 -36.201 40.494  1.00 8.22  ?  458  VAL A CB  1 
ATOM   1820 C CG1 . VAL A 1 235 ? -11.592 -36.802 40.041  1.00 8.40  ?  458  VAL A CG1 1 
ATOM   1821 C CG2 . VAL A 1 235 ? -13.940 -37.324 40.725  1.00 8.85  ?  458  VAL A CG2 1 
ATOM   1822 N N   . GLN A 1 236 ? -11.917 -33.245 40.566  1.00 9.09  ?  459  GLN A N   1 
ATOM   1823 C CA  . GLN A 1 236 ? -10.890 -32.273 40.183  1.00 9.43  ?  459  GLN A CA  1 
ATOM   1824 C C   . GLN A 1 236 ? -10.415 -31.476 41.396  1.00 9.45  ?  459  GLN A C   1 
ATOM   1825 O O   . GLN A 1 236 ? -9.227  -31.188 41.536  1.00 10.31 ?  459  GLN A O   1 
ATOM   1826 C CB  . GLN A 1 236 ? -11.442 -31.304 39.138  1.00 9.52  ?  459  GLN A CB  1 
ATOM   1827 C CG  . GLN A 1 236 ? -11.800 -32.047 37.827  1.00 10.30 ?  459  GLN A CG  1 
ATOM   1828 C CD  . GLN A 1 236 ? -12.488 -31.089 36.850  1.00 10.90 ?  459  GLN A CD  1 
ATOM   1829 O OE1 . GLN A 1 236 ? -13.387 -30.301 37.211  1.00 11.09 ?  459  GLN A OE1 1 
ATOM   1830 N NE2 . GLN A 1 236 ? -12.021 -31.115 35.602  1.00 11.03 ?  459  GLN A NE2 1 
ATOM   1831 N N   . TYR A 1 237 ? -11.339 -31.144 42.289  1.00 10.23 ?  460  TYR A N   1 
ATOM   1832 C CA  . TYR A 1 237 ? -11.026 -30.319 43.450  1.00 10.85 ?  460  TYR A CA  1 
ATOM   1833 C C   . TYR A 1 237 ? -10.205 -31.081 44.484  1.00 9.82  ?  460  TYR A C   1 
ATOM   1834 O O   . TYR A 1 237 ? -9.221  -30.545 45.012  1.00 11.00 ?  460  TYR A O   1 
ATOM   1835 C CB  . TYR A 1 237 ? -12.350 -29.852 44.058  1.00 11.18 ?  460  TYR A CB  1 
ATOM   1836 C CG  . TYR A 1 237 ? -12.229 -28.762 45.133  1.00 13.28 ?  460  TYR A CG  1 
ATOM   1837 C CD1 . TYR A 1 237 ? -11.932 -27.485 44.776  1.00 13.31 ?  460  TYR A CD1 1 
ATOM   1838 C CD2 . TYR A 1 237 ? -12.467 -29.059 46.479  1.00 13.82 ?  460  TYR A CD2 1 
ATOM   1839 C CE1 . TYR A 1 237 ? -11.800 -26.471 45.720  1.00 15.70 ?  460  TYR A CE1 1 
ATOM   1840 C CE2 . TYR A 1 237 ? -12.375 -28.062 47.458  1.00 12.70 ?  460  TYR A CE2 1 
ATOM   1841 C CZ  . TYR A 1 237 ? -12.044 -26.766 47.072  1.00 15.97 ?  460  TYR A CZ  1 
ATOM   1842 O OH  . TYR A 1 237 ? -11.954 -25.751 48.025  1.00 17.27 ?  460  TYR A OH  1 
ATOM   1843 N N   . PHE A 1 238 ? -10.640 -32.305 44.830  1.00 11.21 ?  461  PHE A N   1 
ATOM   1844 C CA  . PHE A 1 238 ? -9.874  -33.107 45.792  1.00 10.53 ?  461  PHE A CA  1 
ATOM   1845 C C   . PHE A 1 238 ? -8.473  -33.375 45.271  1.00 12.11 ?  461  PHE A C   1 
ATOM   1846 O O   . PHE A 1 238 ? -7.491  -33.292 46.017  1.00 11.78 ?  461  PHE A O   1 
ATOM   1847 C CB  . PHE A 1 238 ? -10.612 -34.433 46.097  1.00 9.62  ?  461  PHE A CB  1 
ATOM   1848 C CG  . PHE A 1 238 ? -12.007 -34.246 46.657  1.00 9.24  ?  461  PHE A CG  1 
ATOM   1849 C CD1 . PHE A 1 238 ? -12.354 -33.065 47.337  1.00 11.19 ?  461  PHE A CD1 1 
ATOM   1850 C CD2 . PHE A 1 238 ? -12.951 -35.293 46.548  1.00 10.55 ?  461  PHE A CD2 1 
ATOM   1851 C CE1 . PHE A 1 238 ? -13.654 -32.874 47.857  1.00 12.36 ?  461  PHE A CE1 1 
ATOM   1852 C CE2 . PHE A 1 238 ? -14.256 -35.118 47.034  1.00 10.90 ?  461  PHE A CE2 1 
ATOM   1853 C CZ  . PHE A 1 238 ? -14.595 -33.897 47.703  1.00 12.26 ?  461  PHE A CZ  1 
ATOM   1854 N N   . TYR A 1 239 ? -8.343  -33.661 43.977  1.00 9.99  ?  462  TYR A N   1 
ATOM   1855 C CA  . TYR A 1 239 ? -7.016  -33.873 43.407  1.00 12.13 ?  462  TYR A CA  1 
ATOM   1856 C C   . TYR A 1 239 ? -6.135  -32.642 43.607  1.00 13.24 ?  462  TYR A C   1 
ATOM   1857 O O   . TYR A 1 239 ? -4.948  -32.749 43.956  1.00 12.54 ?  462  TYR A O   1 
ATOM   1858 C CB  . TYR A 1 239 ? -7.148  -34.209 41.918  1.00 10.37 ?  462  TYR A CB  1 
ATOM   1859 C CG  . TYR A 1 239 ? -5.806  -34.366 41.217  1.00 12.24 ?  462  TYR A CG  1 
ATOM   1860 C CD1 . TYR A 1 239 ? -5.137  -35.564 41.252  1.00 15.72 ?  462  TYR A CD1 1 
ATOM   1861 C CD2 . TYR A 1 239 ? -5.247  -33.310 40.501  1.00 13.23 ?  462  TYR A CD2 1 
ATOM   1862 C CE1 . TYR A 1 239 ? -3.898  -35.729 40.569  1.00 15.71 ?  462  TYR A CE1 1 
ATOM   1863 C CE2 . TYR A 1 239 ? -4.038  -33.473 39.837  1.00 16.36 ?  462  TYR A CE2 1 
ATOM   1864 C CZ  . TYR A 1 239 ? -3.399  -34.691 39.866  1.00 14.43 ?  462  TYR A CZ  1 
ATOM   1865 O OH  . TYR A 1 239 ? -2.183  -34.826 39.216  1.00 21.75 ?  462  TYR A OH  1 
ATOM   1866 N N   . GLN A 1 240 ? -6.691  -31.464 43.359  1.00 11.79 ?  463  GLN A N   1 
ATOM   1867 C CA  . GLN A 1 240 ? -5.935  -30.223 43.471  1.00 13.59 ?  463  GLN A CA  1 
ATOM   1868 C C   . GLN A 1 240 ? -5.628  -29.855 44.929  1.00 15.06 ?  463  GLN A C   1 
ATOM   1869 O O   . GLN A 1 240 ? -4.513  -29.424 45.245  1.00 16.07 ?  463  GLN A O   1 
ATOM   1870 C CB  . GLN A 1 240 ? -6.722  -29.089 42.793  1.00 17.72 ?  463  GLN A CB  1 
ATOM   1871 C CG  . GLN A 1 240 ? -5.847  -27.873 42.380  1.00 22.46 ?  463  GLN A CG  1 
ATOM   1872 C CD  . GLN A 1 240 ? -4.653  -28.194 41.418  1.00 22.44 ?  463  GLN A CD  1 
ATOM   1873 O OE1 . GLN A 1 240 ? -3.576  -27.578 41.547  1.00 20.14 ?  463  GLN A OE1 1 
ATOM   1874 N NE2 . GLN A 1 240 ? -4.857  -29.119 40.434  1.00 19.50 ?  463  GLN A NE2 1 
ATOM   1875 N N   . GLU A 1 241 ? -6.607  -30.004 45.823  1.00 11.73 ?  464  GLU A N   1 
ATOM   1876 C CA  . GLU A 1 241 ? -6.474  -29.580 47.224  1.00 14.39 ?  464  GLU A CA  1 
ATOM   1877 C C   . GLU A 1 241 ? -5.634  -30.544 48.042  1.00 17.35 ?  464  GLU A C   1 
ATOM   1878 O O   . GLU A 1 241 ? -4.787  -30.108 48.841  1.00 16.00 ?  464  GLU A O   1 
ATOM   1879 C CB  . GLU A 1 241 ? -7.848  -29.455 47.888  1.00 15.43 ?  464  GLU A CB  1 
ATOM   1880 C CG  . GLU A 1 241 ? -8.651  -28.283 47.350  1.00 16.15 ?  464  GLU A CG  1 
ATOM   1881 C CD  . GLU A 1 241 ? -8.071  -26.984 47.790  1.00 23.37 ?  464  GLU A CD  1 
ATOM   1882 O OE1 . GLU A 1 241 ? -8.106  -26.714 49.009  1.00 21.94 ?  464  GLU A OE1 1 
ATOM   1883 O OE2 . GLU A 1 241 ? -7.547  -26.241 46.913  1.00 23.55 -1 464  GLU A OE2 1 
ATOM   1884 N N   . ALA A 1 242 ? -5.874  -31.841 47.863  1.00 13.76 ?  465  ALA A N   1 
ATOM   1885 C CA  . ALA A 1 242 ? -5.197  -32.925 48.601  1.00 14.13 ?  465  ALA A CA  1 
ATOM   1886 C C   . ALA A 1 242 ? -5.145  -32.642 50.101  1.00 17.30 ?  465  ALA A C   1 
ATOM   1887 O O   . ALA A 1 242 ? -4.090  -32.762 50.750  1.00 18.37 ?  465  ALA A O   1 
ATOM   1888 C CB  . ALA A 1 242 ? -3.799  -33.158 48.034  1.00 14.83 ?  465  ALA A CB  1 
ATOM   1889 N N   . ALA A 1 243 ? -6.270  -32.252 50.636  1.00 14.55 ?  466  ALA A N   1 
ATOM   1890 C CA  . ALA A 1 243 ? -6.365  -31.968 52.074  1.00 17.17 ?  466  ALA A CA  1 
ATOM   1891 C C   . ALA A 1 243 ? -6.468  -33.279 52.856  1.00 16.96 ?  466  ALA A C   1 
ATOM   1892 O O   . ALA A 1 243 ? -7.270  -34.153 52.500  1.00 15.03 ?  466  ALA A O   1 
ATOM   1893 C CB  . ALA A 1 243 ? -7.577  -31.062 52.342  1.00 18.17 ?  466  ALA A CB  1 
ATOM   1894 N N   . PRO A 1 244 ? -5.674  -33.464 53.924  1.00 19.01 ?  467  PRO A N   1 
ATOM   1895 C CA  . PRO A 1 244 ? -5.736  -34.732 54.669  1.00 17.68 ?  467  PRO A CA  1 
ATOM   1896 C C   . PRO A 1 244 ? -7.079  -34.933 55.341  1.00 17.46 ?  467  PRO A C   1 
ATOM   1897 O O   . PRO A 1 244 ? -7.695  -33.983 55.822  1.00 21.18 ?  467  PRO A O   1 
ATOM   1898 C CB  . PRO A 1 244 ? -4.625  -34.608 55.727  1.00 19.50 ?  467  PRO A CB  1 
ATOM   1899 C CG  . PRO A 1 244 ? -3.941  -33.308 55.524  1.00 23.77 ?  467  PRO A CG  1 
ATOM   1900 C CD  . PRO A 1 244 ? -4.612  -32.547 54.364  1.00 17.90 ?  467  PRO A CD  1 
ATOM   1901 N N   . ALA A 1 245 ? -7.522  -36.181 55.388  1.00 16.71 ?  468  ALA A N   1 
ATOM   1902 C CA  . ALA A 1 245 ? -8.776  -36.499 56.057  1.00 16.74 ?  468  ALA A CA  1 
ATOM   1903 C C   . ALA A 1 245 ? -8.537  -36.614 57.561  1.00 19.16 ?  468  ALA A C   1 
ATOM   1904 O O   . ALA A 1 245 ? -7.647  -37.357 57.979  1.00 20.91 ?  468  ALA A O   1 
ATOM   1905 C CB  . ALA A 1 245 ? -9.336  -37.809 55.525  1.00 18.73 ?  468  ALA A CB  1 
ATOM   1906 N N   . GLN A 1 246 ? -9.327  -35.903 58.366  1.00 19.89 ?  469  GLN A N   1 
ATOM   1907 C CA  . GLN A 1 246 ? -9.095  -35.932 59.813  1.00 20.34 ?  469  GLN A CA  1 
ATOM   1908 C C   . GLN A 1 246 ? -9.859  -37.064 60.492  1.00 21.44 ?  469  GLN A C   1 
ATOM   1909 O O   . GLN A 1 246 ? -9.557  -37.404 61.646  1.00 23.03 ?  469  GLN A O   1 
ATOM   1910 C CB  . GLN A 1 246 ? -9.488  -34.588 60.421  1.00 21.93 ?  469  GLN A CB  1 
ATOM   1911 C CG  . GLN A 1 246 ? -8.555  -33.393 60.103  1.00 21.22 ?  469  GLN A CG  1 
ATOM   1912 C CD  . GLN A 1 246 ? -7.079  -33.723 60.102  1.00 29.31 ?  469  GLN A CD  1 
ATOM   1913 O OE1 . GLN A 1 246 ? -6.537  -34.209 61.101  1.00 30.91 ?  469  GLN A OE1 1 
ATOM   1914 N NE2 . GLN A 1 246 ? -6.413  -33.477 58.983  1.00 32.08 ?  469  GLN A NE2 1 
ATOM   1915 N N   . SER A 1 247 ? -10.835 -37.655 59.804  1.00 18.79 ?  470  SER A N   1 
ATOM   1916 C CA  . SER A 1 247 ? -11.566 -38.847 60.204  1.00 17.37 ?  470  SER A CA  1 
ATOM   1917 C C   . SER A 1 247 ? -12.026 -39.549 58.931  1.00 18.99 ?  470  SER A C   1 
ATOM   1918 O O   . SER A 1 247 ? -11.683 -39.132 57.823  1.00 20.07 ?  470  SER A O   1 
ATOM   1919 C CB  . SER A 1 247 ? -12.759 -38.505 61.107  1.00 20.21 ?  470  SER A CB  1 
ATOM   1920 O OG  . SER A 1 247 ? -13.881 -38.068 60.344  1.00 20.48 ?  470  SER A OG  1 
ATOM   1921 N N   . ASP A 1 248 ? -12.793 -40.622 59.069  1.00 19.72 ?  471  ASP A N   1 
ATOM   1922 C CA  . ASP A 1 248 ? -13.237 -41.309 57.863  1.00 18.10 ?  471  ASP A CA  1 
ATOM   1923 C C   . ASP A 1 248 ? -14.494 -40.687 57.254  1.00 16.99 ?  471  ASP A C   1 
ATOM   1924 O O   . ASP A 1 248 ? -14.932 -41.150 56.198  1.00 15.62 ?  471  ASP A O   1 
ATOM   1925 C CB  . ASP A 1 248 ? -13.500 -42.785 58.144  1.00 19.79 ?  471  ASP A CB  1 
ATOM   1926 C CG  . ASP A 1 248 ? -12.221 -43.583 58.391  1.00 26.00 ?  471  ASP A CG  1 
ATOM   1927 O OD1 . ASP A 1 248 ? -11.110 -43.174 57.996  1.00 28.09 ?  471  ASP A OD1 1 
ATOM   1928 O OD2 . ASP A 1 248 ? -12.339 -44.659 58.992  1.00 34.30 -1 471  ASP A OD2 1 
ATOM   1929 N N   . VAL A 1 249 ? -15.112 -39.701 57.907  1.00 17.55 ?  472  VAL A N   1 
ATOM   1930 C CA  . VAL A 1 249 ? -16.427 -39.223 57.496  1.00 17.62 ?  472  VAL A CA  1 
ATOM   1931 C C   . VAL A 1 249 ? -16.458 -37.706 57.618  1.00 18.67 ?  472  VAL A C   1 
ATOM   1932 O O   . VAL A 1 249 ? -16.259 -37.157 58.716  1.00 19.43 ?  472  VAL A O   1 
ATOM   1933 C CB  . VAL A 1 249 ? -17.562 -39.850 58.331  1.00 20.63 ?  472  VAL A CB  1 
ATOM   1934 C CG1 . VAL A 1 249 ? -18.890 -39.311 57.877  1.00 19.80 ?  472  VAL A CG1 1 
ATOM   1935 C CG2 . VAL A 1 249 ? -17.522 -41.350 58.232  1.00 20.80 ?  472  VAL A CG2 1 
ATOM   1936 N N   . ALA A 1 250 ? -16.731 -37.018 56.495  1.00 14.51 ?  473  ALA A N   1 
ATOM   1937 C CA  . ALA A 1 250 ? -16.911 -35.565 56.463  1.00 15.69 ?  473  ALA A CA  1 
ATOM   1938 C C   . ALA A 1 250 ? -18.402 -35.226 56.442  1.00 15.81 ?  473  ALA A C   1 
ATOM   1939 O O   . ALA A 1 250 ? -19.131 -35.673 55.551  1.00 17.37 ?  473  ALA A O   1 
ATOM   1940 C CB  . ALA A 1 250 ? -16.201 -34.954 55.237  1.00 14.26 ?  473  ALA A CB  1 
ATOM   1941 N N   . LEU A 1 251 ? -18.860 -34.405 57.400  1.00 13.81 ?  474  LEU A N   1 
ATOM   1942 C CA  . LEU A 1 251 ? -20.270 -34.018 57.458  1.00 14.84 ?  474  LEU A CA  1 
ATOM   1943 C C   . LEU A 1 251 ? -20.508 -32.805 56.551  1.00 13.74 ?  474  LEU A C   1 
ATOM   1944 O O   . LEU A 1 251 ? -19.889 -31.758 56.746  1.00 14.37 ?  474  LEU A O   1 
ATOM   1945 C CB  . LEU A 1 251 ? -20.656 -33.685 58.908  1.00 16.38 ?  474  LEU A CB  1 
ATOM   1946 C CG  . LEU A 1 251 ? -22.115 -33.240 59.110  1.00 16.36 ?  474  LEU A CG  1 
ATOM   1947 C CD1 . LEU A 1 251 ? -23.128 -34.297 58.825  1.00 17.17 ?  474  LEU A CD1 1 
ATOM   1948 C CD2 . LEU A 1 251 ? -22.284 -32.696 60.551  1.00 20.11 ?  474  LEU A CD2 1 
ATOM   1949 N N   . LEU A 1 252 ? -21.380 -32.948 55.552  1.00 15.19 ?  475  LEU A N   1 
ATOM   1950 C CA  . LEU A 1 252 ? -21.717 -31.835 54.672  1.00 15.11 ?  475  LEU A CA  1 
ATOM   1951 C C   . LEU A 1 252 ? -23.148 -31.393 54.920  1.00 13.10 ?  475  LEU A C   1 
ATOM   1952 O O   . LEU A 1 252 ? -24.024 -32.228 55.154  1.00 14.94 ?  475  LEU A O   1 
ATOM   1953 C CB  . LEU A 1 252 ? -21.573 -32.246 53.195  1.00 14.90 ?  475  LEU A CB  1 
ATOM   1954 C CG  . LEU A 1 252 ? -20.288 -32.989 52.770  1.00 12.38 ?  475  LEU A CG  1 
ATOM   1955 C CD1 . LEU A 1 252 ? -20.400 -33.212 51.229  1.00 13.75 ?  475  LEU A CD1 1 
ATOM   1956 C CD2 . LEU A 1 252 ? -19.015 -32.199 53.115  1.00 13.67 ?  475  LEU A CD2 1 
ATOM   1957 N N   . ARG A 1 253 ? -23.388 -30.081 54.824  1.00 15.37 ?  476  ARG A N   1 
ATOM   1958 C CA  . ARG A 1 253 ? -24.734 -29.520 54.815  1.00 17.17 ?  476  ARG A CA  1 
ATOM   1959 C C   . ARG A 1 253 ? -25.048 -28.934 53.435  1.00 15.71 ?  476  ARG A C   1 
ATOM   1960 O O   . ARG A 1 253 ? -24.181 -28.296 52.824  1.00 17.13 ?  476  ARG A O   1 
ATOM   1961 C CB  . ARG A 1 253 ? -24.838 -28.437 55.903  1.00 16.09 ?  476  ARG A CB  1 
ATOM   1962 C CG  . ARG A 1 253 ? -25.300 -28.998 57.270  1.00 18.83 ?  476  ARG A CG  1 
ATOM   1963 C CD  . ARG A 1 253 ? -24.304 -29.981 57.866  1.00 17.58 ?  476  ARG A CD  1 
ATOM   1964 N NE  . ARG A 1 253 ? -24.778 -30.464 59.169  1.00 20.25 ?  476  ARG A NE  1 
ATOM   1965 C CZ  . ARG A 1 253 ? -24.485 -29.862 60.315  1.00 20.00 ?  476  ARG A CZ  1 
ATOM   1966 N NH1 . ARG A 1 253 ? -23.711 -28.794 60.352  1.00 19.40 ?  476  ARG A NH1 1 
ATOM   1967 N NH2 . ARG A 1 253 ? -24.996 -30.341 61.450  1.00 22.06 ?  476  ARG A NH2 1 
ATOM   1968 N N   . PHE A 1 254 ? -26.242 -29.234 52.913  1.00 13.07 ?  477  PHE A N   1 
ATOM   1969 C CA  . PHE A 1 254 ? -26.716 -28.664 51.654  1.00 15.23 ?  477  PHE A CA  1 
ATOM   1970 C C   . PHE A 1 254 ? -27.489 -27.394 52.005  1.00 16.88 ?  477  PHE A C   1 
ATOM   1971 O O   . PHE A 1 254 ? -28.512 -27.466 52.711  1.00 18.05 ?  477  PHE A O   1 
ATOM   1972 C CB  . PHE A 1 254 ? -27.570 -29.662 50.855  1.00 15.44 ?  477  PHE A CB  1 
ATOM   1973 C CG  . PHE A 1 254 ? -27.877 -29.189 49.434  1.00 15.70 ?  477  PHE A CG  1 
ATOM   1974 C CD1 . PHE A 1 254 ? -26.993 -29.450 48.390  1.00 13.71 ?  477  PHE A CD1 1 
ATOM   1975 C CD2 . PHE A 1 254 ? -29.025 -28.443 49.163  1.00 15.40 ?  477  PHE A CD2 1 
ATOM   1976 C CE1 . PHE A 1 254 ? -27.262 -28.993 47.085  1.00 14.93 ?  477  PHE A CE1 1 
ATOM   1977 C CE2 . PHE A 1 254 ? -29.291 -27.955 47.874  1.00 16.33 ?  477  PHE A CE2 1 
ATOM   1978 C CZ  . PHE A 1 254 ? -28.382 -28.250 46.812  1.00 14.55 ?  477  PHE A CZ  1 
ATOM   1979 N N   . VAL A 1 255 ? -27.003 -26.245 51.530  1.00 15.20 ?  478  VAL A N   1 
ATOM   1980 C CA  . VAL A 1 255 ? -27.442 -24.940 52.038  1.00 18.55 ?  478  VAL A CA  1 
ATOM   1981 C C   . VAL A 1 255 ? -27.992 -24.062 50.910  1.00 18.50 ?  478  VAL A C   1 
ATOM   1982 O O   . VAL A 1 255 ? -27.458 -24.032 49.791  1.00 17.83 ?  478  VAL A O   1 
ATOM   1983 C CB  . VAL A 1 255 ? -26.306 -24.197 52.765  1.00 20.51 ?  478  VAL A CB  1 
ATOM   1984 C CG1 . VAL A 1 255 ? -25.136 -23.956 51.872  1.00 24.22 ?  478  VAL A CG1 1 
ATOM   1985 C CG2 . VAL A 1 255 ? -26.815 -22.889 53.402  1.00 22.77 ?  478  VAL A CG2 1 
ATOM   1986 N N   . ASN A 1 256 ? -29.043 -23.291 51.236  1.00 18.73 ?  479  ASN A N   1 
ATOM   1987 C CA  . ASN A 1 256 ? -29.524 -22.234 50.339  1.00 18.52 ?  479  ASN A CA  1 
ATOM   1988 C C   . ASN A 1 256 ? -28.759 -20.939 50.622  1.00 19.98 ?  479  ASN A C   1 
ATOM   1989 O O   . ASN A 1 256 ? -28.847 -20.419 51.738  1.00 21.53 ?  479  ASN A O   1 
ATOM   1990 C CB  . ASN A 1 256 ? -31.016 -22.015 50.521  1.00 18.73 ?  479  ASN A CB  1 
ATOM   1991 C CG  . ASN A 1 256 ? -31.571 -20.964 49.550  1.00 22.63 ?  479  ASN A CG  1 
ATOM   1992 O OD1 . ASN A 1 256 ? -30.885 -19.992 49.182  1.00 22.23 ?  479  ASN A OD1 1 
ATOM   1993 N ND2 . ASN A 1 256 ? -32.791 -21.188 49.096  1.00 24.24 ?  479  ASN A ND2 1 
ATOM   1994 N N   . PRO A 1 257 ? -27.963 -20.415 49.686  1.00 21.49 ?  480  PRO A N   1 
ATOM   1995 C CA  . PRO A 1 257 ? -27.082 -19.291 50.037  1.00 21.20 ?  480  PRO A CA  1 
ATOM   1996 C C   . PRO A 1 257 ? -27.826 -17.977 50.209  1.00 22.91 ?  480  PRO A C   1 
ATOM   1997 O O   . PRO A 1 257 ? -27.231 -17.025 50.712  1.00 25.71 ?  480  PRO A O   1 
ATOM   1998 C CB  . PRO A 1 257 ? -26.109 -19.227 48.855  1.00 21.95 ?  480  PRO A CB  1 
ATOM   1999 C CG  . PRO A 1 257 ? -26.966 -19.714 47.701  1.00 21.05 ?  480  PRO A CG  1 
ATOM   2000 C CD  . PRO A 1 257 ? -27.851 -20.783 48.258  1.00 20.92 ?  480  PRO A CD  1 
ATOM   2001 N N   . ASP A 1 258 ? -29.090 -17.913 49.803  1.00 24.27 ?  481  ASP A N   1 
ATOM   2002 C CA  . ASP A 1 258 ? -29.852 -16.675 49.905  1.00 27.49 ?  481  ASP A CA  1 
ATOM   2003 C C   . ASP A 1 258 ? -30.356 -16.487 51.316  1.00 28.45 ?  481  ASP A C   1 
ATOM   2004 O O   . ASP A 1 258 ? -30.332 -15.364 51.854  1.00 29.38 ?  481  ASP A O   1 
ATOM   2005 C CB  . ASP A 1 258 ? -31.046 -16.706 48.948  1.00 27.47 ?  481  ASP A CB  1 
ATOM   2006 C CG  . ASP A 1 258 ? -30.638 -16.516 47.512  1.00 29.35 ?  481  ASP A CG  1 
ATOM   2007 O OD1 . ASP A 1 258 ? -29.525 -15.979 47.266  1.00 30.63 ?  481  ASP A OD1 1 
ATOM   2008 O OD2 . ASP A 1 258 ? -31.432 -16.898 46.628  1.00 32.30 -1 481  ASP A OD2 1 
ATOM   2009 N N   . THR A 1 259 ? -30.822 -17.588 51.913  1.00 27.70 ?  482  THR A N   1 
ATOM   2010 C CA  . THR A 1 259 ? -31.385 -17.600 53.257  1.00 27.01 ?  482  THR A CA  1 
ATOM   2011 C C   . THR A 1 259 ? -30.462 -18.196 54.304  1.00 29.73 ?  482  THR A C   1 
ATOM   2012 O O   . THR A 1 259 ? -30.699 -17.991 55.500  1.00 31.36 ?  482  THR A O   1 
ATOM   2013 C CB  . THR A 1 259 ? -32.687 -18.394 53.260  1.00 27.16 ?  482  THR A CB  1 
ATOM   2014 O OG1 . THR A 1 259 ? -32.393 -19.743 52.873  1.00 26.77 ?  482  THR A OG1 1 
ATOM   2015 C CG2 . THR A 1 259 ? -33.662 -17.824 52.240  1.00 28.82 ?  482  THR A CG2 1 
ATOM   2016 N N   . GLY A 1 260 ? -29.431 -18.932 53.895  1.00 26.11 ?  483  GLY A N   1 
ATOM   2017 C CA  . GLY A 1 260 ? -28.640 -19.677 54.854  1.00 27.35 ?  483  GLY A CA  1 
ATOM   2018 C C   . GLY A 1 260 ? -29.336 -20.898 55.409  1.00 24.41 ?  483  GLY A C   1 
ATOM   2019 O O   . GLY A 1 260 ? -28.794 -21.546 56.307  1.00 31.56 ?  483  GLY A O   1 
ATOM   2020 N N   . ARG A 1 261 ? -30.505 -21.240 54.899  1.00 25.03 ?  484  ARG A N   1 
ATOM   2021 C CA  . ARG A 1 261 ? -31.261 -22.388 55.392  1.00 26.11 ?  484  ARG A CA  1 
ATOM   2022 C C   . ARG A 1 261 ? -30.582 -23.694 54.968  1.00 27.00 ?  484  ARG A C   1 
ATOM   2023 O O   . ARG A 1 261 ? -30.184 -23.850 53.804  1.00 22.87 ?  484  ARG A O   1 
ATOM   2024 C CB  . ARG A 1 261 ? -32.689 -22.336 54.846  1.00 30.65 ?  484  ARG A CB  1 
ATOM   2025 C CG  . ARG A 1 261 ? -33.607 -21.301 55.534  1.00 44.22 ?  484  ARG A CG  1 
ATOM   2026 C CD  . ARG A 1 261 ? -33.814 -21.618 57.015  1.00 52.90 ?  484  ARG A CD  1 
ATOM   2027 N NE  . ARG A 1 261 ? -33.528 -20.490 57.900  1.00 64.40 ?  484  ARG A NE  1 
ATOM   2028 C CZ  . ARG A 1 261 ? -34.430 -19.594 58.288  1.00 70.78 ?  484  ARG A CZ  1 
ATOM   2029 N NH1 . ARG A 1 261 ? -35.690 -19.669 57.894  1.00 73.30 ?  484  ARG A NH1 1 
ATOM   2030 N NH2 . ARG A 1 261 ? -34.061 -18.607 59.104  1.00 65.46 ?  484  ARG A NH2 1 
ATOM   2031 N N   . VAL A 1 262 ? -30.437 -24.632 55.910  1.00 23.93 ?  485  VAL A N   1 
ATOM   2032 C CA  . VAL A 1 262 ? -29.881 -25.951 55.600  1.00 23.39 ?  485  VAL A CA  1 
ATOM   2033 C C   . VAL A 1 262 ? -31.040 -26.838 55.180  1.00 23.46 ?  485  VAL A C   1 
ATOM   2034 O O   . VAL A 1 262 ? -32.026 -26.970 55.906  1.00 23.58 ?  485  VAL A O   1 
ATOM   2035 C CB  . VAL A 1 262 ? -29.110 -26.537 56.803  1.00 21.07 ?  485  VAL A CB  1 
ATOM   2036 C CG1 . VAL A 1 262 ? -28.755 -28.018 56.571  1.00 22.19 ?  485  VAL A CG1 1 
ATOM   2037 C CG2 . VAL A 1 262 ? -27.850 -25.766 57.032  1.00 24.28 ?  485  VAL A CG2 1 
ATOM   2038 N N   . LEU A 1 263 ? -30.942 -27.440 53.999  1.00 20.84 ?  486  LEU A N   1 
ATOM   2039 C CA  . LEU A 1 263 ? -32.005 -28.290 53.480  1.00 20.32 ?  486  LEU A CA  1 
ATOM   2040 C C   . LEU A 1 263 ? -31.853 -29.730 53.979  1.00 21.68 ?  486  LEU A C   1 
ATOM   2041 O O   . LEU A 1 263 ? -32.840 -30.400 54.312  1.00 22.44 ?  486  LEU A O   1 
ATOM   2042 C CB  . LEU A 1 263 ? -31.990 -28.248 51.943  1.00 23.45 ?  486  LEU A CB  1 
ATOM   2043 C CG  . LEU A 1 263 ? -33.048 -29.031 51.172  1.00 28.70 ?  486  LEU A CG  1 
ATOM   2044 C CD1 . LEU A 1 263 ? -34.370 -28.260 51.380  1.00 29.46 ?  486  LEU A CD1 1 
ATOM   2045 C CD2 . LEU A 1 263 ? -32.794 -29.113 49.656  1.00 27.12 ?  486  LEU A CD2 1 
ATOM   2046 N N   . PHE A 1 264 ? -30.623 -30.244 54.016  1.00 20.05 ?  487  PHE A N   1 
ATOM   2047 C CA  . PHE A 1 264 ? -30.378 -31.598 54.512  1.00 19.11 ?  487  PHE A CA  1 
ATOM   2048 C C   . PHE A 1 264 ? -28.895 -31.715 54.814  1.00 17.34 ?  487  PHE A C   1 
ATOM   2049 O O   . PHE A 1 264 ? -28.099 -30.847 54.450  1.00 16.26 ?  487  PHE A O   1 
ATOM   2050 C CB  . PHE A 1 264 ? -30.846 -32.702 53.534  1.00 18.63 ?  487  PHE A CB  1 
ATOM   2051 C CG  . PHE A 1 264 ? -30.028 -32.797 52.238  1.00 17.16 ?  487  PHE A CG  1 
ATOM   2052 C CD1 . PHE A 1 264 ? -30.374 -32.016 51.132  1.00 17.06 ?  487  PHE A CD1 1 
ATOM   2053 C CD2 . PHE A 1 264 ? -28.934 -33.674 52.126  1.00 16.66 ?  487  PHE A CD2 1 
ATOM   2054 C CE1 . PHE A 1 264 ? -29.617 -32.087 49.931  1.00 16.69 ?  487  PHE A CE1 1 
ATOM   2055 C CE2 . PHE A 1 264 ? -28.162 -33.746 50.919  1.00 16.29 ?  487  PHE A CE2 1 
ATOM   2056 C CZ  . PHE A 1 264 ? -28.527 -32.963 49.832  1.00 14.08 ?  487  PHE A CZ  1 
ATOM   2057 N N   . GLU A 1 265 ? -28.536 -32.769 55.526  1.00 16.49 ?  488  GLU A N   1 
ATOM   2058 C CA  . GLU A 1 265 ? -27.124 -33.065 55.732  1.00 17.81 ?  488  GLU A CA  1 
ATOM   2059 C C   . GLU A 1 265 ? -26.811 -34.481 55.268  1.00 16.18 ?  488  GLU A C   1 
ATOM   2060 O O   . GLU A 1 265 ? -27.694 -35.329 55.103  1.00 15.87 ?  488  GLU A O   1 
ATOM   2061 C CB  . GLU A 1 265 ? -26.694 -32.875 57.204  1.00 16.80 ?  488  GLU A CB  1 
ATOM   2062 C CG  . GLU A 1 265 ? -27.475 -33.770 58.175  1.00 17.91 ?  488  GLU A CG  1 
ATOM   2063 C CD  . GLU A 1 265 ? -27.054 -33.558 59.650  1.00 20.29 ?  488  GLU A CD  1 
ATOM   2064 O OE1 . GLU A 1 265 ? -26.407 -32.553 59.967  1.00 22.07 ?  488  GLU A OE1 1 
ATOM   2065 O OE2 . GLU A 1 265 ? -27.383 -34.414 60.479  1.00 23.32 -1 488  GLU A OE2 1 
ATOM   2066 N N   . CYS A 1 266 ? -25.526 -34.738 55.054  1.00 15.44 ?  489  CYS A N   1 
ATOM   2067 C CA  . CYS A 1 266 ? -25.121 -36.012 54.463  1.00 14.27 ?  489  CYS A CA  1 
ATOM   2068 C C   . CYS A 1 266 ? -23.681 -36.293 54.840  1.00 13.76 ?  489  CYS A C   1 
ATOM   2069 O O   . CYS A 1 266 ? -22.971 -35.417 55.353  1.00 15.08 ?  489  CYS A O   1 
ATOM   2070 C CB  . CYS A 1 266 ? -25.294 -36.012 52.923  1.00 14.01 ?  489  CYS A CB  1 
ATOM   2071 S SG  . CYS A 1 266 ? -24.263 -34.811 52.027  1.00 14.00 ?  489  CYS A SG  1 
ATOM   2072 N N   . LYS A 1 267 ? -23.259 -37.538 54.606  1.00 14.29 ?  490  LYS A N   1 
ATOM   2073 C CA  . LYS A 1 267 ? -21.905 -37.967 54.940  1.00 14.64 ?  490  LYS A CA  1 
ATOM   2074 C C   . LYS A 1 267 ? -21.105 -38.145 53.659  1.00 12.59 ?  490  LYS A C   1 
ATOM   2075 O O   . LYS A 1 267 ? -21.502 -38.950 52.810  1.00 13.50 ?  490  LYS A O   1 
ATOM   2076 C CB  . LYS A 1 267 ? -21.909 -39.319 55.662  1.00 15.24 ?  490  LYS A CB  1 
ATOM   2077 C CG  . LYS A 1 267 ? -22.429 -39.254 57.120  1.00 15.41 ?  490  LYS A CG  1 
ATOM   2078 C CD  . LYS A 1 267 ? -22.394 -40.659 57.729  1.00 18.48 ?  490  LYS A CD  1 
ATOM   2079 C CE  . LYS A 1 267 ? -22.850 -40.617 59.211  1.00 22.48 ?  490  LYS A CE  1 
ATOM   2080 N NZ  . LYS A 1 267 ? -23.186 -42.029 59.653  1.00 20.68 ?  490  LYS A NZ  1 
ATOM   2081 N N   . LEU A 1 268 ? -19.961 -37.484 53.575  1.00 13.07 ?  491  LEU A N   1 
ATOM   2082 C CA  . LEU A 1 268 ? -18.984 -37.735 52.505  1.00 13.76 ?  491  LEU A CA  1 
ATOM   2083 C C   . LEU A 1 268 ? -17.876 -38.616 53.076  1.00 13.53 ?  491  LEU A C   1 
ATOM   2084 O O   . LEU A 1 268 ? -17.077 -38.166 53.895  1.00 13.72 ?  491  LEU A O   1 
ATOM   2085 C CB  . LEU A 1 268 ? -18.436 -36.433 51.935  1.00 12.73 ?  491  LEU A CB  1 
ATOM   2086 C CG  . LEU A 1 268 ? -17.208 -36.550 51.000  1.00 11.82 ?  491  LEU A CG  1 
ATOM   2087 C CD1 . LEU A 1 268 ? -17.490 -37.447 49.796  1.00 13.00 ?  491  LEU A CD1 1 
ATOM   2088 C CD2 . LEU A 1 268 ? -16.710 -35.159 50.602  1.00 12.99 ?  491  LEU A CD2 1 
ATOM   2089 N N   . HIS A 1 269 ? -17.837 -39.873 52.636  1.00 13.10 ?  492  HIS A N   1 
ATOM   2090 C CA  . HIS A 1 269 ? -16.871 -40.828 53.172  1.00 14.23 ?  492  HIS A CA  1 
ATOM   2091 C C   . HIS A 1 269 ? -15.510 -40.587 52.542  1.00 15.17 ?  492  HIS A C   1 
ATOM   2092 O O   . HIS A 1 269 ? -15.419 -40.213 51.364  1.00 14.88 ?  492  HIS A O   1 
ATOM   2093 C CB  . HIS A 1 269 ? -17.390 -42.222 52.882  1.00 15.30 ?  492  HIS A CB  1 
ATOM   2094 C CG  . HIS A 1 269 ? -18.710 -42.466 53.566  1.00 20.73 ?  492  HIS A CG  1 
ATOM   2095 N ND1 . HIS A 1 269 ? -18.841 -43.251 54.698  1.00 24.35 ?  492  HIS A ND1 1 
ATOM   2096 C CD2 . HIS A 1 269 ? -19.958 -42.012 53.273  1.00 19.41 ?  492  HIS A CD2 1 
ATOM   2097 C CE1 . HIS A 1 269 ? -20.106 -43.237 55.094  1.00 23.59 ?  492  HIS A CE1 1 
ATOM   2098 N NE2 . HIS A 1 269 ? -20.807 -42.497 54.237  1.00 21.33 ?  492  HIS A NE2 1 
ATOM   2099 N N   . LYS A 1 270 ? -14.441 -40.792 53.335  1.00 13.92 ?  493  LYS A N   1 
ATOM   2100 C CA  . LYS A 1 270 ? -13.086 -40.478 52.881  1.00 13.25 ?  493  LYS A CA  1 
ATOM   2101 C C   . LYS A 1 270 ? -12.736 -41.227 51.595  1.00 13.12 ?  493  LYS A C   1 
ATOM   2102 O O   . LYS A 1 270 ? -11.992 -40.704 50.754  1.00 12.50 ?  493  LYS A O   1 
ATOM   2103 C CB  . LYS A 1 270 ? -12.090 -40.805 54.018  1.00 16.89 ?  493  LYS A CB  1 
ATOM   2104 C CG  . LYS A 1 270 ? -10.611 -40.699 53.676  1.00 23.49 ?  493  LYS A CG  1 
ATOM   2105 C CD  . LYS A 1 270 ? -9.742  -41.455 54.735  1.00 22.88 ?  493  LYS A CD  1 
ATOM   2106 C CE  . LYS A 1 270 ? -8.273  -41.451 54.303  1.00 27.74 ?  493  LYS A CE  1 
ATOM   2107 N NZ  . LYS A 1 270 ? -7.350  -41.874 55.409  1.00 31.73 ?  493  LYS A NZ  1 
ATOM   2108 N N   . SER A 1 271 ? -13.275 -42.437 51.403  1.00 14.11 ?  494  SER A N   1 
ATOM   2109 C CA  . SER A 1 271 ? -12.939 -43.202 50.212  1.00 13.89 ?  494  SER A CA  1 
ATOM   2110 C C   . SER A 1 271 ? -13.724 -42.716 48.982  1.00 13.53 ?  494  SER A C   1 
ATOM   2111 O O   . SER A 1 271 ? -13.523 -43.253 47.892  1.00 12.83 ?  494  SER A O   1 
ATOM   2112 C CB  . SER A 1 271 ? -13.157 -44.701 50.472  1.00 12.88 ?  494  SER A CB  1 
ATOM   2113 O OG  . SER A 1 271 ? -14.515 -45.010 50.721  1.00 17.41 ?  494  SER A OG  1 
ATOM   2114 N N   . GLY A 1 272 ? -14.624 -41.741 49.148  1.00 10.59 ?  495  GLY A N   1 
ATOM   2115 C CA  . GLY A 1 272 ? -15.204 -41.020 48.004  1.00 10.22 ?  495  GLY A CA  1 
ATOM   2116 C C   . GLY A 1 272 ? -16.606 -41.420 47.604  1.00 10.06 ?  495  GLY A C   1 
ATOM   2117 O O   . GLY A 1 272 ? -16.822 -41.791 46.440  1.00 10.94 ?  495  GLY A O   1 
ATOM   2118 N N   . TYR A 1 273 ? -17.575 -41.314 48.518  1.00 10.97 ?  496  TYR A N   1 
ATOM   2119 C CA  . TYR A 1 273 ? -18.973 -41.506 48.176  1.00 12.86 ?  496  TYR A CA  1 
ATOM   2120 C C   . TYR A 1 273 ? -19.778 -40.843 49.277  1.00 12.01 ?  496  TYR A C   1 
ATOM   2121 O O   . TYR A 1 273 ? -19.235 -40.515 50.344  1.00 12.24 ?  496  TYR A O   1 
ATOM   2122 C CB  . TYR A 1 273 ? -19.352 -42.996 47.990  1.00 10.68 ?  496  TYR A CB  1 
ATOM   2123 C CG  . TYR A 1 273 ? -19.205 -43.873 49.231  1.00 13.99 ?  496  TYR A CG  1 
ATOM   2124 C CD1 . TYR A 1 273 ? -17.990 -44.496 49.536  1.00 16.37 ?  496  TYR A CD1 1 
ATOM   2125 C CD2 . TYR A 1 273 ? -20.294 -44.091 50.087  1.00 16.09 ?  496  TYR A CD2 1 
ATOM   2126 C CE1 . TYR A 1 273 ? -17.864 -45.327 50.662  1.00 16.70 ?  496  TYR A CE1 1 
ATOM   2127 C CE2 . TYR A 1 273 ? -20.159 -44.900 51.252  1.00 16.80 ?  496  TYR A CE2 1 
ATOM   2128 C CZ  . TYR A 1 273 ? -18.935 -45.505 51.513  1.00 19.12 ?  496  TYR A CZ  1 
ATOM   2129 O OH  . TYR A 1 273 ? -18.798 -46.316 52.644  1.00 20.52 ?  496  TYR A OH  1 
ATOM   2130 N N   . VAL A 1 274 ? -21.071 -40.645 49.007  1.00 10.40 ?  497  VAL A N   1 
ATOM   2131 C CA  . VAL A 1 274 ? -21.961 -39.894 49.895  1.00 12.42 ?  497  VAL A CA  1 
ATOM   2132 C C   . VAL A 1 274 ? -23.138 -40.761 50.357  1.00 13.41 ?  497  VAL A C   1 
ATOM   2133 O O   . VAL A 1 274 ? -23.744 -41.496 49.561  1.00 12.37 ?  497  VAL A O   1 
ATOM   2134 C CB  . VAL A 1 274 ? -22.468 -38.619 49.176  1.00 10.90 ?  497  VAL A CB  1 
ATOM   2135 C CG1 . VAL A 1 274 ? -23.384 -37.807 50.130  1.00 12.90 ?  497  VAL A CG1 1 
ATOM   2136 C CG2 . VAL A 1 274 ? -21.313 -37.740 48.679  1.00 14.15 ?  497  VAL A CG2 1 
ATOM   2137 N N   . THR A 1 275 ? -23.500 -40.660 51.657  1.00 12.93 ?  498  THR A N   1 
ATOM   2138 C CA  . THR A 1 275 ? -24.735 -41.303 52.127  1.00 13.02 ?  498  THR A CA  1 
ATOM   2139 C C   . THR A 1 275 ? -25.653 -40.289 52.821  1.00 12.32 ?  498  THR A C   1 
ATOM   2140 O O   . THR A 1 275 ? -25.214 -39.246 53.321  1.00 14.52 ?  498  THR A O   1 
ATOM   2141 C CB  . THR A 1 275 ? -24.452 -42.489 53.099  1.00 13.92 ?  498  THR A CB  1 
ATOM   2142 O OG1 . THR A 1 275 ? -23.687 -42.020 54.207  1.00 14.49 ?  498  THR A OG1 1 
ATOM   2143 C CG2 . THR A 1 275 ? -23.686 -43.586 52.384  1.00 15.99 ?  498  THR A CG2 1 
ATOM   2144 N N   . VAL A 1 276 ? -26.956 -40.601 52.809  1.00 14.71 ?  499  VAL A N   1 
ATOM   2145 C CA  . VAL A 1 276 ? -27.997 -39.826 53.482  1.00 15.05 ?  499  VAL A CA  1 
ATOM   2146 C C   . VAL A 1 276 ? -28.852 -40.775 54.334  1.00 16.58 ?  499  VAL A C   1 
ATOM   2147 O O   . VAL A 1 276 ? -28.912 -41.981 54.094  1.00 15.54 ?  499  VAL A O   1 
ATOM   2148 C CB  . VAL A 1 276 ? -28.903 -39.086 52.476  1.00 15.06 ?  499  VAL A CB  1 
ATOM   2149 C CG1 . VAL A 1 276 ? -28.159 -37.858 51.912  1.00 13.86 ?  499  VAL A CG1 1 
ATOM   2150 C CG2 . VAL A 1 276 ? -29.398 -40.033 51.376  1.00 16.16 ?  499  VAL A CG2 1 
ATOM   2151 N N   . ALA A 1 277 ? -29.579 -40.197 55.296  1.00 17.04 ?  500  ALA A N   1 
ATOM   2152 C CA  . ALA A 1 277 ? -30.489 -40.992 56.122  1.00 17.86 ?  500  ALA A CA  1 
ATOM   2153 C C   . ALA A 1 277 ? -31.855 -40.952 55.456  1.00 17.73 ?  500  ALA A C   1 
ATOM   2154 O O   . ALA A 1 277 ? -32.584 -39.960 55.562  1.00 20.13 ?  500  ALA A O   1 
ATOM   2155 C CB  . ALA A 1 277 ? -30.525 -40.471 57.560  1.00 20.09 ?  500  ALA A CB  1 
ATOM   2156 N N   . HIS A 1 278 ? -32.185 -42.013 54.726  1.00 16.91 ?  501  HIS A N   1 
ATOM   2157 C CA  . HIS A 1 278 ? -33.459 -42.113 54.026  1.00 18.91 ?  501  HIS A CA  1 
ATOM   2158 C C   . HIS A 1 278 ? -33.722 -43.565 53.663  1.00 21.07 ?  501  HIS A C   1 
ATOM   2159 O O   . HIS A 1 278 ? -32.791 -44.330 53.400  1.00 19.50 ?  501  HIS A O   1 
ATOM   2160 C CB  . HIS A 1 278 ? -33.481 -41.254 52.746  1.00 17.29 ?  501  HIS A CB  1 
ATOM   2161 C CG  . HIS A 1 278 ? -34.820 -41.220 52.080  1.00 18.78 ?  501  HIS A CG  1 
ATOM   2162 N ND1 . HIS A 1 278 ? -35.811 -40.336 52.457  1.00 22.30 ?  501  HIS A ND1 1 
ATOM   2163 C CD2 . HIS A 1 278 ? -35.353 -41.988 51.098  1.00 20.59 ?  501  HIS A CD2 1 
ATOM   2164 C CE1 . HIS A 1 278 ? -36.891 -40.556 51.726  1.00 22.84 ?  501  HIS A CE1 1 
ATOM   2165 N NE2 . HIS A 1 278 ? -36.641 -41.552 50.895  1.00 21.23 ?  501  HIS A NE2 1 
ATOM   2166 N N   . THR A 1 279 ? -35.001 -43.939 53.645  1.00 20.06 ?  502  THR A N   1 
ATOM   2167 C CA  . THR A 1 279 ? -35.416 -45.250 53.169  1.00 20.68 ?  502  THR A CA  1 
ATOM   2168 C C   . THR A 1 279 ? -36.392 -45.065 52.013  1.00 22.88 ?  502  THR A C   1 
ATOM   2169 O O   . THR A 1 279 ? -37.459 -44.448 52.183  1.00 24.84 ?  502  THR A O   1 
ATOM   2170 C CB  . THR A 1 279 ? -36.043 -46.092 54.302  1.00 25.76 ?  502  THR A CB  1 
ATOM   2171 O OG1 . THR A 1 279 ? -35.074 -46.323 55.334  1.00 23.10 ?  502  THR A OG1 1 
ATOM   2172 C CG2 . THR A 1 279 ? -36.479 -47.432 53.763  1.00 24.26 ?  502  THR A CG2 1 
ATOM   2173 N N   . GLY A 1 280 ? -36.034 -45.597 50.848  1.00 21.14 ?  503  GLY A N   1 
ATOM   2174 C CA  . GLY A 1 280 ? -36.861 -45.556 49.654  1.00 21.27 ?  503  GLY A CA  1 
ATOM   2175 C C   . GLY A 1 280 ? -36.204 -44.794 48.506  1.00 21.26 ?  503  GLY A C   1 
ATOM   2176 O O   . GLY A 1 280 ? -35.204 -44.091 48.666  1.00 19.66 ?  503  GLY A O   1 
ATOM   2177 N N   . GLN A 1 281 ? -36.813 -44.937 47.325  1.00 19.88 ?  504  GLN A N   1 
ATOM   2178 C CA  . GLN A 1 281 ? -36.399 -44.112 46.189  1.00 19.25 ?  504  GLN A CA  1 
ATOM   2179 C C   . GLN A 1 281 ? -36.987 -42.715 46.298  1.00 22.55 ?  504  GLN A C   1 
ATOM   2180 O O   . GLN A 1 281 ? -38.176 -42.561 46.591  1.00 22.45 ?  504  GLN A O   1 
ATOM   2181 C CB  . GLN A 1 281 ? -36.792 -44.756 44.853  1.00 20.39 ?  504  GLN A CB  1 
ATOM   2182 C CG  . GLN A 1 281 ? -36.344 -46.229 44.696  1.00 27.58 ?  504  GLN A CG  1 
ATOM   2183 C CD  . GLN A 1 281 ? -36.497 -46.711 43.265  1.00 38.07 ?  504  GLN A CD  1 
ATOM   2184 O OE1 . GLN A 1 281 ? -37.583 -46.664 42.709  1.00 39.90 ?  504  GLN A OE1 1 
ATOM   2185 N NE2 . GLN A 1 281 ? -35.395 -47.165 42.658  1.00 42.68 ?  504  GLN A NE2 1 
ATOM   2186 N N   . HIS A 1 282 ? -36.149 -41.690 46.078  1.00 17.97 ?  505  HIS A N   1 
ATOM   2187 C CA  . HIS A 1 282 ? -36.580 -40.305 46.218  1.00 19.96 ?  505  HIS A CA  1 
ATOM   2188 C C   . HIS A 1 282 ? -35.755 -39.381 45.326  1.00 17.76 ?  505  HIS A C   1 
ATOM   2189 O O   . HIS A 1 282 ? -34.519 -39.359 45.420  1.00 16.73 ?  505  HIS A O   1 
ATOM   2190 C CB  . HIS A 1 282 ? -36.462 -39.837 47.674  1.00 17.54 ?  505  HIS A CB  1 
ATOM   2191 C CG  . HIS A 1 282 ? -36.943 -38.447 47.897  1.00 21.28 ?  505  HIS A CG  1 
ATOM   2192 N ND1 . HIS A 1 282 ? -38.266 -38.092 47.751  1.00 23.66 ?  505  HIS A ND1 1 
ATOM   2193 C CD2 . HIS A 1 282 ? -36.284 -37.316 48.243  1.00 20.80 ?  505  HIS A CD2 1 
ATOM   2194 C CE1 . HIS A 1 282 ? -38.399 -36.801 47.989  1.00 25.32 ?  505  HIS A CE1 1 
ATOM   2195 N NE2 . HIS A 1 282 ? -37.215 -36.305 48.292  1.00 23.87 ?  505  HIS A NE2 1 
ATOM   2196 N N   . ASP A 1 283 ? -36.455 -38.603 44.488  1.00 18.21 ?  506  ASP A N   1 
ATOM   2197 C CA  . ASP A 1 283 ? -35.852 -37.478 43.781  1.00 19.33 ?  506  ASP A CA  1 
ATOM   2198 C C   . ASP A 1 283 ? -35.813 -36.274 44.721  1.00 20.45 ?  506  ASP A C   1 
ATOM   2199 O O   . ASP A 1 283 ? -36.871 -35.769 45.149  1.00 19.15 ?  506  ASP A O   1 
ATOM   2200 C CB  . ASP A 1 283 ? -36.650 -37.130 42.517  1.00 19.72 ?  506  ASP A CB  1 
ATOM   2201 C CG  . ASP A 1 283 ? -36.502 -38.148 41.428  1.00 25.80 ?  506  ASP A CG  1 
ATOM   2202 O OD1 . ASP A 1 283 ? -35.359 -38.444 41.019  1.00 24.52 ?  506  ASP A OD1 1 
ATOM   2203 O OD2 . ASP A 1 283 ? -37.545 -38.659 40.970  1.00 31.97 -1 506  ASP A OD2 1 
ATOM   2204 N N   . LEU A 1 284 ? -34.615 -35.803 45.050  1.00 17.23 ?  507  LEU A N   1 
ATOM   2205 C CA  . LEU A 1 284 ? -34.519 -34.659 45.954  1.00 18.10 ?  507  LEU A CA  1 
ATOM   2206 C C   . LEU A 1 284 ? -35.025 -33.396 45.278  1.00 18.47 ?  507  LEU A C   1 
ATOM   2207 O O   . LEU A 1 284 ? -34.697 -33.124 44.123  1.00 19.31 ?  507  LEU A O   1 
ATOM   2208 C CB  . LEU A 1 284 ? -33.069 -34.456 46.416  1.00 18.85 ?  507  LEU A CB  1 
ATOM   2209 C CG  . LEU A 1 284 ? -32.606 -35.342 47.571  1.00 13.40 ?  507  LEU A CG  1 
ATOM   2210 C CD1 . LEU A 1 284 ? -32.402 -36.775 47.058  1.00 15.85 ?  507  LEU A CD1 1 
ATOM   2211 C CD2 . LEU A 1 284 ? -31.342 -34.820 48.265  1.00 16.57 ?  507  LEU A CD2 1 
ATOM   2212 N N   . VAL A 1 285 ? -35.818 -32.604 46.008  1.00 19.94 ?  508  VAL A N   1 
ATOM   2213 C CA  . VAL A 1 285 ? -36.250 -31.277 45.566  1.00 19.19 ?  508  VAL A CA  1 
ATOM   2214 C C   . VAL A 1 285 ? -35.355 -30.235 46.230  1.00 21.42 ?  508  VAL A C   1 
ATOM   2215 O O   . VAL A 1 285 ? -35.357 -30.063 47.458  1.00 20.75 ?  508  VAL A O   1 
ATOM   2216 C CB  . VAL A 1 285 ? -37.729 -31.025 45.909  1.00 20.28 ?  508  VAL A CB  1 
ATOM   2217 C CG1 . VAL A 1 285 ? -38.103 -29.600 45.504  1.00 18.68 ?  508  VAL A CG1 1 
ATOM   2218 C CG2 . VAL A 1 285 ? -38.597 -32.088 45.229  1.00 21.37 ?  508  VAL A CG2 1 
ATOM   2219 N N   . ILE A 1 286 ? -34.569 -29.535 45.427  1.00 18.63 ?  509  ILE A N   1 
ATOM   2220 C CA  . ILE A 1 286 ? -33.585 -28.596 45.957  1.00 18.71 ?  509  ILE A CA  1 
ATOM   2221 C C   . ILE A 1 286 ? -33.755 -27.223 45.324  1.00 19.24 ?  509  ILE A C   1 
ATOM   2222 O O   . ILE A 1 286 ? -34.211 -27.124 44.176  1.00 17.75 ?  509  ILE A O   1 
ATOM   2223 C CB  . ILE A 1 286 ? -32.152 -29.123 45.721  1.00 18.28 ?  509  ILE A CB  1 
ATOM   2224 C CG1 . ILE A 1 286 ? -31.894 -29.293 44.217  1.00 17.25 ?  509  ILE A CG1 1 
ATOM   2225 C CG2 . ILE A 1 286 ? -31.955 -30.485 46.449  1.00 19.44 ?  509  ILE A CG2 1 
ATOM   2226 C CD1 . ILE A 1 286 ? -30.415 -29.617 43.862  1.00 15.21 ?  509  ILE A CD1 1 
ATOM   2227 N N   . PRO A 1 287 ? -33.379 -26.149 46.019  1.00 18.07 ?  510  PRO A N   1 
ATOM   2228 C CA  . PRO A 1 287 ? -33.237 -24.847 45.368  1.00 18.27 ?  510  PRO A CA  1 
ATOM   2229 C C   . PRO A 1 287 ? -32.114 -24.905 44.356  1.00 17.19 ?  510  PRO A C   1 
ATOM   2230 O O   . PRO A 1 287 ? -31.041 -25.450 44.657  1.00 15.40 ?  510  PRO A O   1 
ATOM   2231 C CB  . PRO A 1 287 ? -32.870 -23.901 46.519  1.00 20.01 ?  510  PRO A CB  1 
ATOM   2232 C CG  . PRO A 1 287 ? -32.287 -24.801 47.586  1.00 18.97 ?  510  PRO A CG  1 
ATOM   2233 C CD  . PRO A 1 287 ? -32.898 -26.144 47.412  1.00 19.34 ?  510  PRO A CD  1 
ATOM   2234 N N   . PRO A 1 288 ? -32.312 -24.354 43.165  1.00 18.35 ?  511  PRO A N   1 
ATOM   2235 C CA  . PRO A 1 288 ? -31.277 -24.487 42.114  1.00 18.19 ?  511  PRO A CA  1 
ATOM   2236 C C   . PRO A 1 288 ? -29.983 -23.778 42.434  1.00 19.44 ?  511  PRO A C   1 
ATOM   2237 O O   . PRO A 1 288 ? -28.948 -24.138 41.846  1.00 18.84 ?  511  PRO A O   1 
ATOM   2238 C CB  . PRO A 1 288 ? -31.951 -23.882 40.865  1.00 22.12 ?  511  PRO A CB  1 
ATOM   2239 C CG  . PRO A 1 288 ? -33.019 -22.929 41.444  1.00 20.17 ?  511  PRO A CG  1 
ATOM   2240 C CD  . PRO A 1 288 ? -33.538 -23.693 42.659  1.00 19.06 ?  511  PRO A CD  1 
ATOM   2241 N N   . ASN A 1 289 ? -29.984 -22.793 43.335  1.00 16.29 ?  512  ASN A N   1 
ATOM   2242 C CA  . ASN A 1 289 ? -28.752 -22.154 43.765  1.00 17.56 ?  512  ASN A CA  1 
ATOM   2243 C C   . ASN A 1 289 ? -28.128 -22.804 45.011  1.00 16.61 ?  512  ASN A C   1 
ATOM   2244 O O   . ASN A 1 289 ? -27.098 -22.301 45.487  1.00 16.92 ?  512  ASN A O   1 
ATOM   2245 C CB  . ASN A 1 289 ? -29.013 -20.663 44.029  1.00 18.90 ?  512  ASN A CB  1 
ATOM   2246 C CG  . ASN A 1 289 ? -30.049 -20.454 45.109  1.00 23.13 ?  512  ASN A CG  1 
ATOM   2247 O OD1 . ASN A 1 289 ? -30.924 -21.294 45.316  1.00 20.95 ?  512  ASN A OD1 1 
ATOM   2248 N ND2 . ASN A 1 289 ? -29.966 -19.315 45.798  1.00 26.76 ?  512  ASN A ND2 1 
ATOM   2249 N N   . GLY A 1 290 ? -28.660 -23.946 45.488  1.00 16.56 ?  513  GLY A N   1 
ATOM   2250 C CA  . GLY A 1 290 ? -28.101 -24.580 46.681  1.00 16.41 ?  513  GLY A CA  1 
ATOM   2251 C C   . GLY A 1 290 ? -26.732 -25.194 46.416  1.00 15.99 ?  513  GLY A C   1 
ATOM   2252 O O   . GLY A 1 290 ? -26.389 -25.495 45.285  1.00 15.82 ?  513  GLY A O   1 
ATOM   2253 N N   . TYR A 1 291 ? -25.932 -25.376 47.471  1.00 15.19 ?  514  TYR A N   1 
ATOM   2254 C CA  . TYR A 1 291 ? -24.616 -26.002 47.285  1.00 16.09 ?  514  TYR A CA  1 
ATOM   2255 C C   . TYR A 1 291 ? -24.263 -26.784 48.545  1.00 16.54 ?  514  TYR A C   1 
ATOM   2256 O O   . TYR A 1 291 ? -24.896 -26.631 49.590  1.00 15.93 ?  514  TYR A O   1 
ATOM   2257 C CB  . TYR A 1 291 ? -23.539 -24.930 46.934  1.00 17.11 ?  514  TYR A CB  1 
ATOM   2258 C CG  . TYR A 1 291 ? -23.258 -24.053 48.120  1.00 20.09 ?  514  TYR A CG  1 
ATOM   2259 C CD1 . TYR A 1 291 ? -24.039 -22.935 48.367  1.00 21.13 ?  514  TYR A CD1 1 
ATOM   2260 C CD2 . TYR A 1 291 ? -22.170 -24.280 48.948  1.00 26.12 ?  514  TYR A CD2 1 
ATOM   2261 C CE1 . TYR A 1 291 ? -23.822 -22.140 49.499  1.00 21.74 ?  514  TYR A CE1 1 
ATOM   2262 C CE2 . TYR A 1 291 ? -21.915 -23.485 50.044  1.00 29.06 ?  514  TYR A CE2 1 
ATOM   2263 C CZ  . TYR A 1 291 ? -22.723 -22.412 50.314  1.00 32.99 ?  514  TYR A CZ  1 
ATOM   2264 O OH  . TYR A 1 291 ? -22.434 -21.627 51.421  1.00 36.40 ?  514  TYR A OH  1 
ATOM   2265 N N   . PHE A 1 292 ? -23.226 -27.622 48.441  1.00 15.33 ?  515  PHE A N   1 
ATOM   2266 C CA  . PHE A 1 292 ? -22.742 -28.410 49.575  1.00 16.02 ?  515  PHE A CA  1 
ATOM   2267 C C   . PHE A 1 292 ? -21.671 -27.632 50.339  1.00 15.79 ?  515  PHE A C   1 
ATOM   2268 O O   . PHE A 1 292 ? -20.796 -26.986 49.746  1.00 15.41 ?  515  PHE A O   1 
ATOM   2269 C CB  . PHE A 1 292 ? -22.150 -29.754 49.106  1.00 13.94 ?  515  PHE A CB  1 
ATOM   2270 C CG  . PHE A 1 292 ? -23.163 -30.732 48.558  1.00 12.37 ?  515  PHE A CG  1 
ATOM   2271 C CD1 . PHE A 1 292 ? -23.544 -30.668 47.192  1.00 13.08 ?  515  PHE A CD1 1 
ATOM   2272 C CD2 . PHE A 1 292 ? -23.730 -31.732 49.361  1.00 12.98 ?  515  PHE A CD2 1 
ATOM   2273 C CE1 . PHE A 1 292 ? -24.475 -31.572 46.640  1.00 13.19 ?  515  PHE A CE1 1 
ATOM   2274 C CE2 . PHE A 1 292 ? -24.663 -32.614 48.823  1.00 14.72 ?  515  PHE A CE2 1 
ATOM   2275 C CZ  . PHE A 1 292 ? -25.017 -32.547 47.453  1.00 11.96 ?  515  PHE A CZ  1 
ATOM   2276 N N   . ARG A 1 293 ? -21.693 -27.775 51.668  1.00 13.98 ?  516  ARG A N   1 
ATOM   2277 C CA  . ARG A 1 293 ? -20.756 -27.071 52.540  1.00 15.67 ?  516  ARG A CA  1 
ATOM   2278 C C   . ARG A 1 293 ? -20.208 -28.052 53.572  1.00 14.83 ?  516  ARG A C   1 
ATOM   2279 O O   . ARG A 1 293 ? -20.985 -28.655 54.330  1.00 14.67 ?  516  ARG A O   1 
ATOM   2280 C CB  . ARG A 1 293 ? -21.465 -25.877 53.213  1.00 16.63 ?  516  ARG A CB  1 
ATOM   2281 C CG  . ARG A 1 293 ? -20.548 -24.929 53.971  1.00 19.50 ?  516  ARG A CG  1 
ATOM   2282 C CD  . ARG A 1 293 ? -21.343 -23.959 54.862  1.00 20.21 ?  516  ARG A CD  1 
ATOM   2283 N NE  . ARG A 1 293 ? -22.095 -24.674 55.891  1.00 20.98 ?  516  ARG A NE  1 
ATOM   2284 C CZ  . ARG A 1 293 ? -23.188 -24.206 56.476  1.00 22.41 ?  516  ARG A CZ  1 
ATOM   2285 N NH1 . ARG A 1 293 ? -23.688 -23.020 56.153  1.00 24.39 ?  516  ARG A NH1 1 
ATOM   2286 N NH2 . ARG A 1 293 ? -23.809 -24.946 57.393  1.00 20.71 ?  516  ARG A NH2 1 
ATOM   2287 N N   . PHE A 1 294 ? -18.881 -28.208 53.612  1.00 16.55 ?  517  PHE A N   1 
ATOM   2288 C CA  . PHE A 1 294 ? -18.239 -29.040 54.636  1.00 14.32 ?  517  PHE A CA  1 
ATOM   2289 C C   . PHE A 1 294 ? -18.282 -28.337 55.999  1.00 17.53 ?  517  PHE A C   1 
ATOM   2290 O O   . PHE A 1 294 ? -17.842 -27.193 56.133  1.00 18.99 ?  517  PHE A O   1 
ATOM   2291 C CB  . PHE A 1 294 ? -16.788 -29.349 54.249  1.00 15.10 ?  517  PHE A CB  1 
ATOM   2292 C CG  . PHE A 1 294 ? -15.983 -29.984 55.378  1.00 14.82 ?  517  PHE A CG  1 
ATOM   2293 C CD1 . PHE A 1 294 ? -16.307 -31.263 55.844  1.00 16.69 ?  517  PHE A CD1 1 
ATOM   2294 C CD2 . PHE A 1 294 ? -14.937 -29.302 55.964  1.00 15.67 ?  517  PHE A CD2 1 
ATOM   2295 C CE1 . PHE A 1 294 ? -15.576 -31.848 56.893  1.00 16.38 ?  517  PHE A CE1 1 
ATOM   2296 C CE2 . PHE A 1 294 ? -14.207 -29.878 57.000  1.00 17.25 ?  517  PHE A CE2 1 
ATOM   2297 C CZ  . PHE A 1 294 ? -14.529 -31.156 57.448  1.00 15.67 ?  517  PHE A CZ  1 
ATOM   2298 N N   . ASP A 1 295 ? -18.811 -29.022 57.009  1.00 17.73 ?  518  ASP A N   1 
ATOM   2299 C CA  . ASP A 1 295 ? -18.965 -28.417 58.345  1.00 18.42 ?  518  ASP A CA  1 
ATOM   2300 C C   . ASP A 1 295 ? -18.085 -29.078 59.404  1.00 19.18 ?  518  ASP A C   1 
ATOM   2301 O O   . ASP A 1 295 ? -17.520 -28.381 60.257  1.00 21.71 ?  518  ASP A O   1 
ATOM   2302 C CB  . ASP A 1 295 ? -20.436 -28.471 58.770  1.00 17.79 ?  518  ASP A CB  1 
ATOM   2303 C CG  . ASP A 1 295 ? -21.286 -27.368 58.102  1.00 18.11 ?  518  ASP A CG  1 
ATOM   2304 O OD1 . ASP A 1 295 ? -20.724 -26.472 57.416  1.00 19.13 ?  518  ASP A OD1 1 
ATOM   2305 O OD2 . ASP A 1 295 ? -22.507 -27.415 58.271  1.00 19.28 -1 518  ASP A OD2 1 
ATOM   2306 N N   . SER A 1 296 ? -17.883 -30.391 59.346  1.00 17.24 ?  519  SER A N   1 
ATOM   2307 C CA  . SER A 1 296 ? -17.108 -31.019 60.410  1.00 21.14 ?  519  SER A CA  1 
ATOM   2308 C C   . SER A 1 296 ? -16.669 -32.425 60.016  1.00 17.84 ?  519  SER A C   1 
ATOM   2309 O O   . SER A 1 296 ? -17.422 -33.162 59.369  1.00 19.00 ?  519  SER A O   1 
ATOM   2310 C CB  . SER A 1 296 ? -17.946 -31.082 61.709  1.00 25.45 ?  519  SER A CB  1 
ATOM   2311 O OG  . SER A 1 296 ? -17.127 -31.490 62.765  1.00 32.17 ?  519  SER A OG  1 
ATOM   2312 N N   . TRP A 1 297 ? -15.485 -32.822 60.504  1.00 19.74 ?  520  TRP A N   1 
ATOM   2313 C CA  . TRP A 1 297 ? -15.127 -34.233 60.545  1.00 20.31 ?  520  TRP A CA  1 
ATOM   2314 C C   . TRP A 1 297 ? -15.880 -34.883 61.705  1.00 25.29 ?  520  TRP A C   1 
ATOM   2315 O O   . TRP A 1 297 ? -15.912 -34.316 62.810  1.00 27.56 ?  520  TRP A O   1 
ATOM   2316 C CB  . TRP A 1 297 ? -13.614 -34.394 60.714  1.00 21.53 ?  520  TRP A CB  1 
ATOM   2317 C CG  . TRP A 1 297 ? -12.820 -33.961 59.494  1.00 20.39 ?  520  TRP A CG  1 
ATOM   2318 C CD1 . TRP A 1 297 ? -12.055 -32.828 59.356  1.00 20.71 ?  520  TRP A CD1 1 
ATOM   2319 C CD2 . TRP A 1 297 ? -12.717 -34.668 58.244  1.00 20.56 ?  520  TRP A CD2 1 
ATOM   2320 N NE1 . TRP A 1 297 ? -11.469 -32.803 58.099  1.00 22.01 ?  520  TRP A NE1 1 
ATOM   2321 C CE2 . TRP A 1 297 ? -11.871 -33.911 57.397  1.00 20.31 ?  520  TRP A CE2 1 
ATOM   2322 C CE3 . TRP A 1 297 ? -13.260 -35.858 57.761  1.00 18.36 ?  520  TRP A CE3 1 
ATOM   2323 C CZ2 . TRP A 1 297 ? -11.563 -34.313 56.088  1.00 19.28 ?  520  TRP A CZ2 1 
ATOM   2324 C CZ3 . TRP A 1 297 ? -12.946 -36.266 56.438  1.00 20.44 ?  520  TRP A CZ3 1 
ATOM   2325 C CH2 . TRP A 1 297 ? -12.110 -35.492 55.627  1.00 18.30 ?  520  TRP A CH2 1 
ATOM   2326 N N   . VAL A 1 298 ? -16.497 -36.053 61.467  1.00 22.06 ?  521  VAL A N   1 
ATOM   2327 C CA  . VAL A 1 298 ? -17.254 -36.742 62.514  1.00 20.92 ?  521  VAL A CA  1 
ATOM   2328 C C   . VAL A 1 298 ? -16.757 -38.175 62.663  1.00 25.20 ?  521  VAL A C   1 
ATOM   2329 O O   . VAL A 1 298 ? -16.108 -38.730 61.775  1.00 21.38 ?  521  VAL A O   1 
ATOM   2330 C CB  . VAL A 1 298 ? -18.778 -36.728 62.268  1.00 20.32 ?  521  VAL A CB  1 
ATOM   2331 C CG1 . VAL A 1 298 ? -19.286 -35.273 62.281  1.00 22.61 ?  521  VAL A CG1 1 
ATOM   2332 C CG2 . VAL A 1 298 ? -19.112 -37.440 60.962  1.00 20.75 ?  521  VAL A CG2 1 
ATOM   2333 N N   . ASN A 1 299 ? -17.064 -38.774 63.827  1.00 29.18 ?  522  ASN A N   1 
ATOM   2334 C CA  . ASN A 1 299 ? -16.632 -40.139 64.107  1.00 27.95 ?  522  ASN A CA  1 
ATOM   2335 C C   . ASN A 1 299 ? -17.559 -41.148 63.424  1.00 34.06 ?  522  ASN A C   1 
ATOM   2336 O O   . ASN A 1 299 ? -18.409 -40.805 62.594  1.00 33.01 ?  522  ASN A O   1 
ATOM   2337 C CB  . ASN A 1 299 ? -16.546 -40.381 65.618  1.00 32.91 ?  522  ASN A CB  1 
ATOM   2338 C CG  . ASN A 1 299 ? -17.902 -40.310 66.307  1.00 32.59 ?  522  ASN A CG  1 
ATOM   2339 O OD1 . ASN A 1 299 ? -18.919 -40.733 65.760  1.00 33.72 ?  522  ASN A OD1 1 
ATOM   2340 N ND2 . ASN A 1 299 ? -17.909 -39.804 67.537  1.00 34.24 ?  522  ASN A ND2 1 
ATOM   2341 N N   . GLN A 1 300 ? -17.417 -42.417 63.791  1.00 31.80 ?  523  GLN A N   1 
ATOM   2342 C CA  . GLN A 1 300 ? -18.100 -43.503 63.091  1.00 37.72 ?  523  GLN A CA  1 
ATOM   2343 C C   . GLN A 1 300 ? -19.540 -43.726 63.535  1.00 36.90 ?  523  GLN A C   1 
ATOM   2344 O O   . GLN A 1 300 ? -20.253 -44.508 62.894  1.00 37.69 ?  523  GLN A O   1 
ATOM   2345 C CB  . GLN A 1 300 ? -17.317 -44.807 63.260  1.00 37.78 ?  523  GLN A CB  1 
ATOM   2346 C CG  . GLN A 1 300 ? -16.073 -44.819 62.445  1.00 42.98 ?  523  GLN A CG  1 
ATOM   2347 C CD  . GLN A 1 300 ? -16.369 -44.416 61.012  1.00 42.94 ?  523  GLN A CD  1 
ATOM   2348 O OE1 . GLN A 1 300 ? -15.661 -43.588 60.429  1.00 42.11 ?  523  GLN A OE1 1 
ATOM   2349 N NE2 . GLN A 1 300 ? -17.404 -45.030 60.420  1.00 45.02 ?  523  GLN A NE2 1 
ATOM   2350 N N   . PHE A 1 301 ? -19.993 -43.066 64.596  1.00 37.55 ?  524  PHE A N   1 
ATOM   2351 C CA  . PHE A 1 301 ? -21.336 -43.296 65.106  1.00 38.44 ?  524  PHE A CA  1 
ATOM   2352 C C   . PHE A 1 301 ? -22.246 -42.093 64.920  1.00 36.69 ?  524  PHE A C   1 
ATOM   2353 O O   . PHE A 1 301 ? -23.267 -41.990 65.603  1.00 37.10 ?  524  PHE A O   1 
ATOM   2354 C CB  . PHE A 1 301 ? -21.285 -43.695 66.581  1.00 45.66 ?  524  PHE A CB  1 
ATOM   2355 C CG  . PHE A 1 301 ? -20.159 -44.625 66.915  1.00 45.95 ?  524  PHE A CG  1 
ATOM   2356 C CD1 . PHE A 1 301 ? -18.911 -44.131 67.262  1.00 48.73 ?  524  PHE A CD1 1 
ATOM   2357 C CD2 . PHE A 1 301 ? -20.354 -45.998 66.893  1.00 49.33 ?  524  PHE A CD2 1 
ATOM   2358 C CE1 . PHE A 1 301 ? -17.869 -45.001 67.570  1.00 54.24 ?  524  PHE A CE1 1 
ATOM   2359 C CE2 . PHE A 1 301 ? -19.322 -46.864 67.203  1.00 50.53 ?  524  PHE A CE2 1 
ATOM   2360 C CZ  . PHE A 1 301 ? -18.080 -46.369 67.539  1.00 51.03 ?  524  PHE A CZ  1 
ATOM   2361 N N   . TYR A 1 302 ? -21.914 -41.183 64.008  1.00 30.89 ?  525  TYR A N   1 
ATOM   2362 C CA  . TYR A 1 302 ? -22.779 -40.040 63.787  1.00 25.61 ?  525  TYR A CA  1 
ATOM   2363 C C   . TYR A 1 302 ? -24.078 -40.451 63.103  1.00 28.51 ?  525  TYR A C   1 
ATOM   2364 O O   . TYR A 1 302 ? -24.074 -41.088 62.044  1.00 30.31 ?  525  TYR A O   1 
ATOM   2365 C CB  . TYR A 1 302 ? -22.060 -38.987 62.953  1.00 26.22 ?  525  TYR A CB  1 
ATOM   2366 C CG  . TYR A 1 302 ? -22.695 -37.627 63.003  1.00 24.87 ?  525  TYR A CG  1 
ATOM   2367 C CD1 . TYR A 1 302 ? -22.376 -36.706 63.995  1.00 26.06 ?  525  TYR A CD1 1 
ATOM   2368 C CD2 . TYR A 1 302 ? -23.644 -37.273 62.069  1.00 25.02 ?  525  TYR A CD2 1 
ATOM   2369 C CE1 . TYR A 1 302 ? -22.966 -35.474 64.022  1.00 26.16 ?  525  TYR A CE1 1 
ATOM   2370 C CE2 . TYR A 1 302 ? -24.243 -36.038 62.098  1.00 24.85 ?  525  TYR A CE2 1 
ATOM   2371 C CZ  . TYR A 1 302 ? -23.900 -35.144 63.067  1.00 26.65 ?  525  TYR A CZ  1 
ATOM   2372 O OH  . TYR A 1 302 ? -24.517 -33.905 63.053  1.00 34.21 ?  525  TYR A OH  1 
ATOM   2373 N N   . THR A 1 303 ? -25.198 -40.089 63.717  1.00 25.84 ?  526  THR A N   1 
ATOM   2374 C CA  . THR A 1 303 ? -26.505 -40.278 63.119  1.00 23.35 ?  526  THR A CA  1 
ATOM   2375 C C   . THR A 1 303 ? -26.923 -39.005 62.401  1.00 25.32 ?  526  THR A C   1 
ATOM   2376 O O   . THR A 1 303 ? -26.982 -37.930 63.014  1.00 25.51 ?  526  THR A O   1 
ATOM   2377 C CB  . THR A 1 303 ? -27.542 -40.650 64.178  1.00 27.88 ?  526  THR A CB  1 
ATOM   2378 O OG1 . THR A 1 303 ? -27.225 -41.947 64.712  1.00 27.25 ?  526  THR A OG1 1 
ATOM   2379 C CG2 . THR A 1 303 ? -28.894 -40.666 63.548  1.00 24.29 ?  526  THR A CG2 1 
ATOM   2380 N N   . LEU A 1 304 ? -27.190 -39.121 61.095  1.00 24.47 ?  527  LEU A N   1 
ATOM   2381 C CA  . LEU A 1 304 ? -27.663 -37.975 60.327  1.00 22.15 ?  527  LEU A CA  1 
ATOM   2382 C C   . LEU A 1 304 ? -29.127 -37.676 60.641  1.00 22.81 ?  527  LEU A C   1 
ATOM   2383 O O   . LEU A 1 304 ? -29.932 -38.578 60.853  1.00 23.52 ?  527  LEU A O   1 
ATOM   2384 C CB  . LEU A 1 304 ? -27.516 -38.240 58.817  1.00 20.38 ?  527  LEU A CB  1 
ATOM   2385 C CG  . LEU A 1 304 ? -26.088 -38.371 58.298  1.00 18.99 ?  527  LEU A CG  1 
ATOM   2386 C CD1 . LEU A 1 304 ? -26.187 -39.061 56.947  1.00 18.19 ?  527  LEU A CD1 1 
ATOM   2387 C CD2 . LEU A 1 304 ? -25.445 -36.978 58.178  1.00 17.45 ?  527  LEU A CD2 1 
ATOM   2388 N N   . ALA A 1 305 ? -29.470 -36.393 60.615  1.00 22.67 ?  528  ALA A N   1 
ATOM   2389 C CA  . ALA A 1 305 ? -30.869 -35.988 60.573  1.00 22.98 ?  528  ALA A CA  1 
ATOM   2390 C C   . ALA A 1 305 ? -31.570 -36.557 59.336  1.00 24.23 ?  528  ALA A C   1 
ATOM   2391 O O   . ALA A 1 305 ? -31.010 -36.535 58.232  1.00 23.48 ?  528  ALA A O   1 
ATOM   2392 C CB  . ALA A 1 305 ? -30.966 -34.466 60.582  1.00 22.70 ?  528  ALA A CB  1 
ATOM   2393 N N   . PRO A 1 306 ? -32.777 -37.089 59.480  1.00 24.87 ?  529  PRO A N   1 
ATOM   2394 C CA  . PRO A 1 306 ? -33.495 -37.626 58.316  1.00 22.22 ?  529  PRO A CA  1 
ATOM   2395 C C   . PRO A 1 306 ? -33.552 -36.635 57.161  1.00 25.71 ?  529  PRO A C   1 
ATOM   2396 O O   . PRO A 1 306 ? -33.808 -35.446 57.344  1.00 24.50 ?  529  PRO A O   1 
ATOM   2397 C CB  . PRO A 1 306 ? -34.893 -37.929 58.871  1.00 27.19 ?  529  PRO A CB  1 
ATOM   2398 C CG  . PRO A 1 306 ? -34.622 -38.232 60.305  1.00 24.19 ?  529  PRO A CG  1 
ATOM   2399 C CD  . PRO A 1 306 ? -33.548 -37.272 60.730  1.00 23.72 ?  529  PRO A CD  1 
ATOM   2400 N N   . MET A 1 307 ? -33.313 -37.163 55.963  1.00 24.96 ?  530  MET A N   1 
ATOM   2401 C CA  . MET A 1 307 ? -33.282 -36.420 54.707  1.00 26.23 ?  530  MET A CA  1 
ATOM   2402 C C   . MET A 1 307 ? -34.690 -36.063 54.288  1.00 30.10 ?  530  MET A C   1 
ATOM   2403 O O   . MET A 1 307 ? -34.867 -34.985 53.733  1.00 39.91 ?  530  MET A O   1 
ATOM   2404 C CB  . MET A 1 307 ? -32.586 -37.263 53.620  1.00 26.13 ?  530  MET A CB  1 
ATOM   2405 C CG  . MET A 1 307 ? -32.136 -36.494 52.408  1.00 26.43 ?  530  MET A CG  1 
ATOM   2406 S SD  . MET A 1 307 ? -32.185 -37.571 50.951  1.00 27.96 ?  530  MET A SD  1 
ATOM   2407 C CE  . MET A 1 307 ? -33.968 -37.705 50.732  1.00 23.79 ?  530  MET A CE  1 
ATOM   2408 N N   . GLN B 2 1   ? -14.414 -61.088 15.127  1.00 46.85 ?  1    GLN C N   1 
ATOM   2409 C CA  . GLN B 2 1   ? -14.345 -62.413 15.733  1.00 39.61 ?  1    GLN C CA  1 
ATOM   2410 C C   . GLN B 2 1   ? -15.740 -63.046 15.836  1.00 33.31 ?  1    GLN C C   1 
ATOM   2411 O O   . GLN B 2 1   ? -15.957 -64.071 15.215  1.00 35.04 ?  1    GLN C O   1 
ATOM   2412 C CB  . GLN B 2 1   ? -13.680 -62.362 17.096  1.00 45.46 ?  1    GLN C CB  1 
ATOM   2413 C CG  . GLN B 2 1   ? -12.133 -62.251 17.049  1.00 55.82 ?  1    GLN C CG  1 
ATOM   2414 C CD  . GLN B 2 1   ? -11.643 -60.818 16.814  1.00 58.35 ?  1    GLN C CD  1 
ATOM   2415 O OE1 . GLN B 2 1   ? -12.160 -59.858 17.400  1.00 65.06 ?  1    GLN C OE1 1 
ATOM   2416 N NE2 . GLN B 2 1   ? -10.643 -60.672 15.948  1.00 65.80 ?  1    GLN C NE2 1 
ATOM   2417 N N   . VAL B 2 2   ? -16.695 -62.450 16.563  1.00 30.95 ?  2    VAL C N   1 
ATOM   2418 C CA  . VAL B 2 2   ? -18.059 -62.970 16.499  1.00 30.01 ?  2    VAL C CA  1 
ATOM   2419 C C   . VAL B 2 2   ? -18.615 -62.760 15.090  1.00 34.43 ?  2    VAL C C   1 
ATOM   2420 O O   . VAL B 2 2   ? -18.439 -61.689 14.493  1.00 31.78 ?  2    VAL C O   1 
ATOM   2421 C CB  . VAL B 2 2   ? -18.968 -62.309 17.547  1.00 28.63 ?  2    VAL C CB  1 
ATOM   2422 C CG1 . VAL B 2 2   ? -20.394 -62.655 17.252  1.00 26.38 ?  2    VAL C CG1 1 
ATOM   2423 C CG2 . VAL B 2 2   ? -18.600 -62.744 18.949  1.00 25.52 ?  2    VAL C CG2 1 
ATOM   2424 N N   . GLN B 2 3   ? -19.279 -63.792 14.535  1.00 26.39 ?  3    GLN C N   1 
ATOM   2425 C CA  . GLN B 2 3   ? -19.960 -63.662 13.250  1.00 27.29 ?  3    GLN C CA  1 
ATOM   2426 C C   . GLN B 2 3   ? -21.388 -64.163 13.389  1.00 28.09 ?  3    GLN C C   1 
ATOM   2427 O O   . GLN B 2 3   ? -21.625 -65.172 14.059  1.00 27.76 ?  3    GLN C O   1 
ATOM   2428 C CB  . GLN B 2 3   ? -19.226 -64.416 12.152  1.00 32.25 ?  3    GLN C CB  1 
ATOM   2429 C CG  . GLN B 2 3   ? -17.841 -63.826 11.942  1.00 35.90 ?  3    GLN C CG  1 
ATOM   2430 C CD  . GLN B 2 3   ? -17.159 -64.323 10.691  1.00 46.02 ?  3    GLN C CD  1 
ATOM   2431 O OE1 . GLN B 2 3   ? -16.173 -65.059 10.762  1.00 52.75 ?  3    GLN C OE1 1 
ATOM   2432 N NE2 . GLN B 2 3   ? -17.676 -63.921 9.533   1.00 47.64 ?  3    GLN C NE2 1 
ATOM   2433 N N   . LEU B 2 4   ? -22.333 -63.425 12.795  1.00 22.84 ?  4    LEU C N   1 
ATOM   2434 C CA  . LEU B 2 4   ? -23.749 -63.785 12.783  1.00 23.04 ?  4    LEU C CA  1 
ATOM   2435 C C   . LEU B 2 4   ? -24.259 -63.697 11.349  1.00 24.26 ?  4    LEU C C   1 
ATOM   2436 O O   . LEU B 2 4   ? -24.031 -62.689 10.669  1.00 23.69 ?  4    LEU C O   1 
ATOM   2437 C CB  . LEU B 2 4   ? -24.574 -62.859 13.705  1.00 19.31 ?  4    LEU C CB  1 
ATOM   2438 C CG  . LEU B 2 4   ? -24.123 -62.782 15.168  1.00 20.17 ?  4    LEU C CG  1 
ATOM   2439 C CD1 . LEU B 2 4   ? -24.681 -61.536 15.842  1.00 19.19 ?  4    LEU C CD1 1 
ATOM   2440 C CD2 . LEU B 2 4   ? -24.590 -63.997 15.940  1.00 22.25 ?  4    LEU C CD2 1 
ATOM   2441 N N   . GLN B 2 5   ? -24.920 -64.755 10.872  1.00 21.86 ?  5    GLN C N   1 
ATOM   2442 C CA  . GLN B 2 5   ? -25.267 -64.842 9.450   1.00 24.57 ?  5    GLN C CA  1 
ATOM   2443 C C   . GLN B 2 5   ? -26.671 -65.426 9.311   1.00 26.81 ?  5    GLN C C   1 
ATOM   2444 O O   . GLN B 2 5   ? -26.866 -66.634 9.516   1.00 24.00 ?  5    GLN C O   1 
ATOM   2445 C CB  . GLN B 2 5   ? -24.255 -65.714 8.717   1.00 29.40 ?  5    GLN C CB  1 
ATOM   2446 C CG  . GLN B 2 5   ? -22.959 -65.014 8.345   1.00 37.28 ?  5    GLN C CG  1 
ATOM   2447 C CD  . GLN B 2 5   ? -22.429 -65.436 6.968   1.00 51.33 ?  5    GLN C CD  1 
ATOM   2448 O OE1 . GLN B 2 5   ? -23.168 -65.470 5.977   1.00 56.27 ?  5    GLN C OE1 1 
ATOM   2449 N NE2 . GLN B 2 5   ? -21.145 -65.782 6.916   1.00 56.55 ?  5    GLN C NE2 1 
ATOM   2450 N N   . GLU B 2 6   ? -27.635 -64.581 8.942   1.00 20.35 ?  6    GLU C N   1 
ATOM   2451 C CA  . GLU B 2 6   ? -29.034 -64.982 8.827   1.00 19.55 ?  6    GLU C CA  1 
ATOM   2452 C C   . GLU B 2 6   ? -29.368 -65.412 7.401   1.00 23.83 ?  6    GLU C C   1 
ATOM   2453 O O   . GLU B 2 6   ? -28.775 -64.931 6.420   1.00 22.55 ?  6    GLU C O   1 
ATOM   2454 C CB  . GLU B 2 6   ? -29.975 -63.844 9.228   1.00 21.50 ?  6    GLU C CB  1 
ATOM   2455 C CG  . GLU B 2 6   ? -29.829 -63.393 10.693  1.00 19.44 ?  6    GLU C CG  1 
ATOM   2456 C CD  . GLU B 2 6   ? -28.841 -62.212 10.866  1.00 19.58 ?  6    GLU C CD  1 
ATOM   2457 O OE1 . GLU B 2 6   ? -28.059 -61.919 9.924   1.00 18.60 ?  6    GLU C OE1 1 
ATOM   2458 O OE2 . GLU B 2 6   ? -28.862 -61.612 11.957  1.00 17.84 -1 6    GLU C OE2 1 
ATOM   2459 N N   . SER B 2 7   ? -30.344 -66.329 7.300   1.00 20.81 ?  7    SER C N   1 
ATOM   2460 C CA  . SER B 2 7   ? -30.890 -66.730 6.008   1.00 23.26 ?  7    SER C CA  1 
ATOM   2461 C C   . SER B 2 7   ? -32.323 -67.222 6.186   1.00 23.38 ?  7    SER C C   1 
ATOM   2462 O O   . SER B 2 7   ? -32.808 -67.405 7.308   1.00 23.80 ?  7    SER C O   1 
ATOM   2463 C CB  . SER B 2 7   ? -30.042 -67.825 5.376   1.00 21.91 ?  7    SER C CB  1 
ATOM   2464 O OG  . SER B 2 7   ? -29.978 -68.914 6.262   1.00 28.78 ?  7    SER C OG  1 
ATOM   2465 N N   . GLY B 2 8   ? -33.015 -67.413 5.051   1.00 25.47 ?  8    GLY C N   1 
ATOM   2466 C CA  . GLY B 2 8   ? -34.349 -67.992 5.047   1.00 22.84 ?  8    GLY C CA  1 
ATOM   2467 C C   . GLY B 2 8   ? -35.503 -67.017 4.880   1.00 26.54 ?  8    GLY C C   1 
ATOM   2468 O O   . GLY B 2 8   ? -36.663 -67.460 4.815   1.00 25.66 ?  8    GLY C O   1 
ATOM   2469 N N   . GLY B 2 9   ? -35.239 -65.710 4.821   1.00 24.43 ?  9    GLY C N   1 
ATOM   2470 C CA  . GLY B 2 9   ? -36.308 -64.756 4.590   1.00 26.53 ?  9    GLY C CA  1 
ATOM   2471 C C   . GLY B 2 9   ? -36.849 -64.875 3.167   1.00 27.18 ?  9    GLY C C   1 
ATOM   2472 O O   . GLY B 2 9   ? -36.280 -65.551 2.309   1.00 28.13 ?  9    GLY C O   1 
ATOM   2473 N N   . GLY B 2 10  ? -37.969 -64.209 2.916   1.00 28.43 ?  10   GLY C N   1 
ATOM   2474 C CA  . GLY B 2 10  ? -38.565 -64.259 1.593   1.00 28.94 ?  10   GLY C CA  1 
ATOM   2475 C C   . GLY B 2 10  ? -39.887 -63.533 1.575   1.00 31.19 ?  10   GLY C C   1 
ATOM   2476 O O   . GLY B 2 10  ? -40.305 -62.915 2.565   1.00 27.91 ?  10   GLY C O   1 
ATOM   2477 N N   . LEU B 2 11  ? -40.541 -63.606 0.410   1.00 31.96 ?  11   LEU C N   1 
ATOM   2478 C CA  . LEU B 2 11  ? -41.883 -63.054 0.234   1.00 30.29 ?  11   LEU C CA  1 
ATOM   2479 C C   . LEU B 2 11  ? -42.903 -64.178 0.376   1.00 29.01 ?  11   LEU C C   1 
ATOM   2480 O O   . LEU B 2 11  ? -42.757 -65.240 -0.234  1.00 32.97 ?  11   LEU C O   1 
ATOM   2481 C CB  . LEU B 2 11  ? -42.031 -62.349 -1.123  1.00 31.63 ?  11   LEU C CB  1 
ATOM   2482 C CG  . LEU B 2 11  ? -43.416 -61.849 -1.567  1.00 32.66 ?  11   LEU C CG  1 
ATOM   2483 C CD1 . LEU B 2 11  ? -43.837 -60.595 -0.785  1.00 29.96 ?  11   LEU C CD1 1 
ATOM   2484 C CD2 . LEU B 2 11  ? -43.441 -61.571 -3.074  1.00 29.90 ?  11   LEU C CD2 1 
ATOM   2485 N N   . VAL B 2 12  ? -43.904 -63.960 1.214   1.00 32.47 ?  12   VAL C N   1 
ATOM   2486 C CA  . VAL B 2 12  ? -44.977 -64.929 1.393   1.00 35.58 ?  12   VAL C CA  1 
ATOM   2487 C C   . VAL B 2 12  ? -46.302 -64.189 1.466   1.00 37.13 ?  12   VAL C C   1 
ATOM   2488 O O   . VAL B 2 12  ? -46.364 -62.973 1.680   1.00 35.99 ?  12   VAL C O   1 
ATOM   2489 C CB  . VAL B 2 12  ? -44.780 -65.820 2.648   1.00 35.78 ?  12   VAL C CB  1 
ATOM   2490 C CG1 . VAL B 2 12  ? -43.458 -66.567 2.559   1.00 35.45 ?  12   VAL C CG1 1 
ATOM   2491 C CG2 . VAL B 2 12  ? -44.869 -64.974 3.929   1.00 33.95 ?  12   VAL C CG2 1 
ATOM   2492 N N   . GLN B 2 13  ? -47.372 -64.940 1.240   1.00 35.40 ?  13   GLN C N   1 
ATOM   2493 C CA  . GLN B 2 13  ? -48.707 -64.383 1.358   1.00 40.86 ?  13   GLN C CA  1 
ATOM   2494 C C   . GLN B 2 13  ? -49.143 -64.399 2.816   1.00 39.52 ?  13   GLN C C   1 
ATOM   2495 O O   . GLN B 2 13  ? -48.690 -65.231 3.610   1.00 37.28 ?  13   GLN C O   1 
ATOM   2496 C CB  . GLN B 2 13  ? -49.692 -65.166 0.478   1.00 46.25 ?  13   GLN C CB  1 
ATOM   2497 C CG  . GLN B 2 13  ? -51.128 -64.659 0.507   1.00 59.09 ?  13   GLN C CG  1 
ATOM   2498 C CD  . GLN B 2 13  ? -51.359 -63.495 -0.436  1.00 71.43 ?  13   GLN C CD  1 
ATOM   2499 O OE1 . GLN B 2 13  ? -50.422 -62.773 -0.782  1.00 67.95 ?  13   GLN C OE1 1 
ATOM   2500 N NE2 . GLN B 2 13  ? -52.605 -63.319 -0.877  1.00 74.24 ?  13   GLN C NE2 1 
ATOM   2501 N N   . ALA B 2 14  ? -50.009 -63.450 3.171   1.00 41.41 ?  14   ALA C N   1 
ATOM   2502 C CA  . ALA B 2 14  ? -50.607 -63.451 4.497   1.00 40.58 ?  14   ALA C CA  1 
ATOM   2503 C C   . ALA B 2 14  ? -51.118 -64.846 4.818   1.00 40.12 ?  14   ALA C C   1 
ATOM   2504 O O   . ALA B 2 14  ? -51.840 -65.456 4.023   1.00 41.89 ?  14   ALA C O   1 
ATOM   2505 C CB  . ALA B 2 14  ? -51.740 -62.428 4.569   1.00 45.01 ?  14   ALA C CB  1 
ATOM   2506 N N   . GLY B 2 15  ? -50.702 -65.366 5.969   1.00 35.55 ?  15   GLY C N   1 
ATOM   2507 C CA  . GLY B 2 15  ? -51.062 -66.696 6.399   1.00 34.23 ?  15   GLY C CA  1 
ATOM   2508 C C   . GLY B 2 15  ? -50.020 -67.759 6.128   1.00 33.15 ?  15   GLY C C   1 
ATOM   2509 O O   . GLY B 2 15  ? -50.170 -68.875 6.627   1.00 36.24 ?  15   GLY C O   1 
ATOM   2510 N N   . GLY B 2 16  ? -48.973 -67.450 5.362   1.00 36.40 ?  16   GLY C N   1 
ATOM   2511 C CA  . GLY B 2 16  ? -47.930 -68.407 5.035   1.00 35.63 ?  16   GLY C CA  1 
ATOM   2512 C C   . GLY B 2 16  ? -46.868 -68.562 6.124   1.00 33.61 ?  16   GLY C C   1 
ATOM   2513 O O   . GLY B 2 16  ? -46.976 -68.029 7.230   1.00 32.99 ?  16   GLY C O   1 
ATOM   2514 N N   . SER B 2 17  ? -45.822 -69.329 5.785   1.00 31.49 ?  17   SER C N   1 
ATOM   2515 C CA  . SER B 2 17  ? -44.769 -69.713 6.725   1.00 30.60 ?  17   SER C CA  1 
ATOM   2516 C C   . SER B 2 17  ? -43.394 -69.450 6.135   1.00 29.07 ?  17   SER C C   1 
ATOM   2517 O O   . SER B 2 17  ? -43.191 -69.531 4.920   1.00 28.03 ?  17   SER C O   1 
ATOM   2518 C CB  . SER B 2 17  ? -44.820 -71.206 7.131   1.00 29.34 ?  17   SER C CB  1 
ATOM   2519 O OG  . SER B 2 17  ? -45.988 -71.551 7.868   1.00 36.71 ?  17   SER C OG  1 
ATOM   2520 N N   . LEU B 2 18  ? -42.447 -69.130 7.017   1.00 25.02 ?  18   LEU C N   1 
ATOM   2521 C CA  . LEU B 2 18  ? -41.030 -69.106 6.671   1.00 27.72 ?  18   LEU C CA  1 
ATOM   2522 C C   . LEU B 2 18  ? -40.242 -69.763 7.797   1.00 27.98 ?  18   LEU C C   1 
ATOM   2523 O O   . LEU B 2 18  ? -40.711 -69.854 8.940   1.00 30.34 ?  18   LEU C O   1 
ATOM   2524 C CB  . LEU B 2 18  ? -40.503 -67.666 6.430   1.00 24.57 ?  18   LEU C CB  1 
ATOM   2525 C CG  . LEU B 2 18  ? -41.000 -66.893 5.203   1.00 27.02 ?  18   LEU C CG  1 
ATOM   2526 C CD1 . LEU B 2 18  ? -40.744 -65.348 5.366   1.00 26.59 ?  18   LEU C CD1 1 
ATOM   2527 C CD2 . LEU B 2 18  ? -40.378 -67.443 3.931   1.00 27.65 ?  18   LEU C CD2 1 
ATOM   2528 N N   . ARG B 2 19  ? -39.034 -70.225 7.480   1.00 25.16 ?  19   ARG C N   1 
ATOM   2529 C CA  . ARG B 2 19  ? -38.113 -70.718 8.505   1.00 26.51 ?  19   ARG C CA  1 
ATOM   2530 C C   . ARG B 2 19  ? -36.808 -69.932 8.413   1.00 24.88 ?  19   ARG C C   1 
ATOM   2531 O O   . ARG B 2 19  ? -36.059 -70.067 7.439   1.00 24.51 ?  19   ARG C O   1 
ATOM   2532 C CB  . ARG B 2 19  ? -37.861 -72.220 8.367   1.00 26.60 ?  19   ARG C CB  1 
ATOM   2533 C CG  . ARG B 2 19  ? -37.132 -72.823 9.587   1.00 26.75 ?  19   ARG C CG  1 
ATOM   2534 C CD  . ARG B 2 19  ? -36.961 -74.349 9.431   1.00 32.19 ?  19   ARG C CD  1 
ATOM   2535 N NE  . ARG B 2 19  ? -36.157 -74.971 10.484  1.00 26.91 ?  19   ARG C NE  1 
ATOM   2536 C CZ  . ARG B 2 19  ? -36.621 -75.349 11.668  1.00 28.47 ?  19   ARG C CZ  1 
ATOM   2537 N NH1 . ARG B 2 19  ? -37.890 -75.167 12.007  1.00 26.99 ?  19   ARG C NH1 1 
ATOM   2538 N NH2 . ARG B 2 19  ? -35.787 -75.918 12.535  1.00 31.31 ?  19   ARG C NH2 1 
ATOM   2539 N N   . LEU B 2 20  ? -36.529 -69.110 9.421   1.00 25.10 ?  20   LEU C N   1 
ATOM   2540 C CA  . LEU B 2 20  ? -35.261 -68.396 9.453   1.00 25.30 ?  20   LEU C CA  1 
ATOM   2541 C C   . LEU B 2 20  ? -34.179 -69.222 10.137  1.00 24.82 ?  20   LEU C C   1 
ATOM   2542 O O   . LEU B 2 20  ? -34.446 -69.956 11.086  1.00 22.68 ?  20   LEU C O   1 
ATOM   2543 C CB  . LEU B 2 20  ? -35.415 -67.071 10.196  1.00 21.42 ?  20   LEU C CB  1 
ATOM   2544 C CG  . LEU B 2 20  ? -36.593 -66.193 9.792   1.00 22.16 ?  20   LEU C CG  1 
ATOM   2545 C CD1 . LEU B 2 20  ? -36.383 -64.831 10.429  1.00 23.55 ?  20   LEU C CD1 1 
ATOM   2546 C CD2 . LEU B 2 20  ? -36.694 -66.068 8.262   1.00 23.21 ?  20   LEU C CD2 1 
ATOM   2547 N N   . SER B 2 21  ? -32.938 -69.046 9.673   1.00 21.77 ?  21   SER C N   1 
ATOM   2548 C CA  . SER B 2 21  ? -31.751 -69.671 10.236  1.00 21.61 ?  21   SER C CA  1 
ATOM   2549 C C   . SER B 2 21  ? -30.715 -68.618 10.589  1.00 23.02 ?  21   SER C C   1 
ATOM   2550 O O   . SER B 2 21  ? -30.580 -67.612 9.877   1.00 21.60 ?  21   SER C O   1 
ATOM   2551 C CB  . SER B 2 21  ? -31.091 -70.623 9.223   1.00 24.11 ?  21   SER C CB  1 
ATOM   2552 O OG  . SER B 2 21  ? -31.869 -71.794 9.096   1.00 35.31 ?  21   SER C OG  1 
ATOM   2553 N N   . CYS B 2 22  ? -29.920 -68.902 11.625  1.00 18.66 ?  22   CYS C N   1 
ATOM   2554 C CA  . CYS B 2 22  ? -28.820 -68.002 11.993  1.00 22.75 ?  22   CYS C CA  1 
ATOM   2555 C C   . CYS B 2 22  ? -27.600 -68.825 12.406  1.00 26.86 ?  22   CYS C C   1 
ATOM   2556 O O   . CYS B 2 22  ? -27.654 -69.594 13.377  1.00 27.05 ?  22   CYS C O   1 
ATOM   2557 C CB  . CYS B 2 22  ? -29.248 -67.050 13.116  1.00 24.99 ?  22   CYS C CB  1 
ATOM   2558 S SG  . CYS B 2 22  ? -27.824 -66.148 13.841  1.00 38.23 ?  22   CYS C SG  1 
ATOM   2559 N N   . ALA B 2 23  ? -26.502 -68.662 11.658  1.00 23.40 ?  23   ALA C N   1 
ATOM   2560 C CA  . ALA B 2 23  ? -25.227 -69.317 11.933  1.00 25.97 ?  23   ALA C CA  1 
ATOM   2561 C C   . ALA B 2 23  ? -24.347 -68.378 12.751  1.00 30.58 ?  23   ALA C C   1 
ATOM   2562 O O   . ALA B 2 23  ? -24.029 -67.275 12.291  1.00 27.50 ?  23   ALA C O   1 
ATOM   2563 C CB  . ALA B 2 23  ? -24.523 -69.682 10.626  1.00 28.62 ?  23   ALA C CB  1 
ATOM   2564 N N   . ALA B 2 24  ? -23.938 -68.820 13.944  1.00 24.98 ?  24   ALA C N   1 
ATOM   2565 C CA  . ALA B 2 24  ? -23.152 -68.001 14.865  1.00 30.77 ?  24   ALA C CA  1 
ATOM   2566 C C   . ALA B 2 24  ? -21.792 -68.646 15.089  1.00 37.66 ?  24   ALA C C   1 
ATOM   2567 O O   . ALA B 2 24  ? -21.704 -69.848 15.355  1.00 34.30 ?  24   ALA C O   1 
ATOM   2568 C CB  . ALA B 2 24  ? -23.878 -67.812 16.204  1.00 27.52 ?  24   ALA C CB  1 
ATOM   2569 N N   . SER B 2 25  ? -20.733 -67.853 14.993  1.00 31.61 ?  25   SER C N   1 
ATOM   2570 C CA  . SER B 2 25  ? -19.402 -68.354 15.286  1.00 40.45 ?  25   SER C CA  1 
ATOM   2571 C C   . SER B 2 25  ? -18.642 -67.301 16.079  1.00 48.41 ?  25   SER C C   1 
ATOM   2572 O O   . SER B 2 25  ? -19.073 -66.150 16.203  1.00 48.23 ?  25   SER C O   1 
ATOM   2573 C CB  . SER B 2 25  ? -18.668 -68.741 14.001  1.00 40.33 ?  25   SER C CB  1 
ATOM   2574 O OG  . SER B 2 25  ? -18.428 -67.616 13.176  1.00 39.77 ?  25   SER C OG  1 
ATOM   2575 N N   . GLY B 2 26  ? -17.508 -67.710 16.645  1.00 44.80 ?  26   GLY C N   1 
ATOM   2576 C CA  . GLY B 2 26  ? -16.692 -66.810 17.428  1.00 39.55 ?  26   GLY C CA  1 
ATOM   2577 C C   . GLY B 2 26  ? -16.951 -66.823 18.919  1.00 40.13 ?  26   GLY C C   1 
ATOM   2578 O O   . GLY B 2 26  ? -16.269 -66.091 19.656  1.00 41.01 ?  26   GLY C O   1 
ATOM   2579 N N   . THR B 2 27  ? -17.907 -67.622 19.391  1.00 39.40 ?  27   THR C N   1 
ATOM   2580 C CA  . THR B 2 27  ? -18.187 -67.747 20.816  1.00 45.02 ?  27   THR C CA  1 
ATOM   2581 C C   . THR B 2 27  ? -18.215 -69.220 21.183  1.00 38.42 ?  27   THR C C   1 
ATOM   2582 O O   . THR B 2 27  ? -17.970 -70.101 20.345  1.00 40.98 ?  27   THR C O   1 
ATOM   2583 C CB  . THR B 2 27  ? -19.520 -67.089 21.198  1.00 36.98 ?  27   THR C CB  1 
ATOM   2584 O OG1 . THR B 2 27  ? -20.518 -67.503 20.260  1.00 51.18 ?  27   THR C OG1 1 
ATOM   2585 C CG2 . THR B 2 27  ? -19.354 -65.556 21.186  1.00 44.29 ?  27   THR C CG2 1 
ATOM   2586 N N   . ILE B 2 28  ? -18.518 -69.487 22.449  1.00 35.65 ?  28   ILE C N   1 
ATOM   2587 C CA  . ILE B 2 28  ? -18.773 -70.856 22.900  1.00 39.00 ?  28   ILE C CA  1 
ATOM   2588 C C   . ILE B 2 28  ? -20.283 -71.028 22.760  1.00 29.63 ?  28   ILE C C   1 
ATOM   2589 O O   . ILE B 2 28  ? -21.047 -70.719 23.659  1.00 29.66 ?  28   ILE C O   1 
ATOM   2590 C CB  . ILE B 2 28  ? -18.281 -71.088 24.323  1.00 39.77 ?  28   ILE C CB  1 
ATOM   2591 C CG1 . ILE B 2 28  ? -16.755 -70.965 24.361  1.00 49.03 ?  28   ILE C CG1 1 
ATOM   2592 C CG2 . ILE B 2 28  ? -18.641 -72.492 24.758  1.00 37.67 ?  28   ILE C CG2 1 
ATOM   2593 C CD1 . ILE B 2 28  ? -16.122 -71.338 25.688  1.00 45.17 ?  28   ILE C CD1 1 
ATOM   2594 N N   . PHE B 2 29  ? -20.714 -71.502 21.587  1.00 31.42 ?  29   PHE C N   1 
ATOM   2595 C CA  . PHE B 2 29  ? -22.139 -71.487 21.247  1.00 33.39 ?  29   PHE C CA  1 
ATOM   2596 C C   . PHE B 2 29  ? -23.006 -72.122 22.332  1.00 32.02 ?  29   PHE C C   1 
ATOM   2597 O O   . PHE B 2 29  ? -24.098 -71.627 22.637  1.00 30.68 ?  29   PHE C O   1 
ATOM   2598 C CB  . PHE B 2 29  ? -22.361 -72.188 19.899  1.00 33.66 ?  29   PHE C CB  1 
ATOM   2599 C CG  . PHE B 2 29  ? -23.781 -72.103 19.385  1.00 35.66 ?  29   PHE C CG  1 
ATOM   2600 C CD1 . PHE B 2 29  ? -24.750 -73.001 19.815  1.00 36.84 ?  29   PHE C CD1 1 
ATOM   2601 C CD2 . PHE B 2 29  ? -24.147 -71.134 18.471  1.00 33.05 ?  29   PHE C CD2 1 
ATOM   2602 C CE1 . PHE B 2 29  ? -26.056 -72.924 19.337  1.00 36.47 ?  29   PHE C CE1 1 
ATOM   2603 C CE2 . PHE B 2 29  ? -25.456 -71.054 17.989  1.00 32.59 ?  29   PHE C CE2 1 
ATOM   2604 C CZ  . PHE B 2 29  ? -26.406 -71.947 18.426  1.00 36.83 ?  29   PHE C CZ  1 
ATOM   2605 N N   . SER B 2 30  ? -22.547 -73.227 22.918  1.00 33.51 ?  30   SER C N   1 
ATOM   2606 C CA  . SER B 2 30  ? -23.408 -74.003 23.802  1.00 35.18 ?  30   SER C CA  1 
ATOM   2607 C C   . SER B 2 30  ? -23.717 -73.290 25.106  1.00 33.86 ?  30   SER C C   1 
ATOM   2608 O O   . SER B 2 30  ? -24.736 -73.602 25.733  1.00 38.59 ?  30   SER C O   1 
ATOM   2609 C CB  . SER B 2 30  ? -22.768 -75.368 24.092  1.00 33.95 ?  30   SER C CB  1 
ATOM   2610 O OG  . SER B 2 30  ? -21.531 -75.202 24.759  1.00 36.46 ?  30   SER C OG  1 
ATOM   2611 N N   . ILE B 2 31  ? -22.891 -72.333 25.537  1.00 30.30 ?  31   ILE C N   1 
ATOM   2612 C CA  . ILE B 2 31  ? -23.170 -71.647 26.799  1.00 36.64 ?  31   ILE C CA  1 
ATOM   2613 C C   . ILE B 2 31  ? -23.893 -70.314 26.599  1.00 35.40 ?  31   ILE C C   1 
ATOM   2614 O O   . ILE B 2 31  ? -24.354 -69.721 27.588  1.00 60.19 ?  31   ILE C O   1 
ATOM   2615 C CB  . ILE B 2 31  ? -21.884 -71.443 27.629  1.00 42.28 ?  31   ILE C CB  1 
ATOM   2616 C CG1 . ILE B 2 31  ? -20.839 -70.668 26.847  1.00 42.04 ?  31   ILE C CG1 1 
ATOM   2617 C CG2 . ILE B 2 31  ? -21.280 -72.793 28.018  1.00 50.38 ?  31   ILE C CG2 1 
ATOM   2618 C CD1 . ILE B 2 31  ? -19.873 -69.939 27.752  1.00 50.89 ?  31   ILE C CD1 1 
ATOM   2619 N N   . ASP B 2 32  ? -24.065 -69.868 25.346  1.00 26.34 ?  32   ASP C N   1 
ATOM   2620 C CA  . ASP B 2 32  ? -24.713 -68.596 25.021  1.00 25.99 ?  32   ASP C CA  1 
ATOM   2621 C C   . ASP B 2 32  ? -26.230 -68.738 24.952  1.00 25.83 ?  32   ASP C C   1 
ATOM   2622 O O   . ASP B 2 32  ? -26.763 -69.765 24.502  1.00 22.57 ?  32   ASP C O   1 
ATOM   2623 C CB  . ASP B 2 32  ? -24.229 -68.090 23.661  1.00 22.50 ?  32   ASP C CB  1 
ATOM   2624 C CG  . ASP B 2 32  ? -22.873 -67.397 23.717  1.00 26.10 ?  32   ASP C CG  1 
ATOM   2625 O OD1 . ASP B 2 32  ? -22.363 -67.111 24.822  1.00 28.12 -1 32   ASP C OD1 1 
ATOM   2626 O OD2 . ASP B 2 32  ? -22.322 -67.184 22.619  1.00 27.29 ?  32   ASP C OD2 1 
ATOM   2627 N N   . ALA B 2 33  ? -26.928 -67.666 25.347  1.00 19.34 ?  33   ALA C N   1 
ATOM   2628 C CA  . ALA B 2 33  ? -28.327 -67.468 25.014  1.00 15.99 ?  33   ALA C CA  1 
ATOM   2629 C C   . ALA B 2 33  ? -28.419 -66.648 23.722  1.00 18.02 ?  33   ALA C C   1 
ATOM   2630 O O   . ALA B 2 33  ? -27.510 -65.875 23.391  1.00 17.32 ?  33   ALA C O   1 
ATOM   2631 C CB  . ALA B 2 33  ? -29.048 -66.763 26.161  1.00 18.85 ?  33   ALA C CB  1 
ATOM   2632 N N   . PHE B 2 34  ? -29.498 -66.854 22.969  1.00 18.10 ?  34   PHE C N   1 
ATOM   2633 C CA  . PHE B 2 34  ? -29.654 -66.158 21.696  1.00 18.74 ?  34   PHE C CA  1 
ATOM   2634 C C   . PHE B 2 34  ? -31.034 -65.529 21.593  1.00 19.41 ?  34   PHE C C   1 
ATOM   2635 O O   . PHE B 2 34  ? -32.005 -65.959 22.227  1.00 19.32 ?  34   PHE C O   1 
ATOM   2636 C CB  . PHE B 2 34  ? -29.422 -67.097 20.507  1.00 18.60 ?  34   PHE C CB  1 
ATOM   2637 C CG  . PHE B 2 34  ? -27.989 -67.473 20.337  1.00 20.64 ?  34   PHE C CG  1 
ATOM   2638 C CD1 . PHE B 2 34  ? -27.121 -66.644 19.652  1.00 19.18 ?  34   PHE C CD1 1 
ATOM   2639 C CD2 . PHE B 2 34  ? -27.475 -68.643 20.915  1.00 22.69 ?  34   PHE C CD2 1 
ATOM   2640 C CE1 . PHE B 2 34  ? -25.788 -66.965 19.511  1.00 22.27 ?  34   PHE C CE1 1 
ATOM   2641 C CE2 . PHE B 2 34  ? -26.130 -68.964 20.785  1.00 25.62 ?  34   PHE C CE2 1 
ATOM   2642 C CZ  . PHE B 2 34  ? -25.286 -68.140 20.083  1.00 26.68 ?  34   PHE C CZ  1 
ATOM   2643 N N   . GLY B 2 35  ? -31.126 -64.501 20.753  1.00 17.21 ?  35   GLY C N   1 
ATOM   2644 C CA  . GLY B 2 35  ? -32.404 -63.871 20.514  1.00 16.17 ?  35   GLY C CA  1 
ATOM   2645 C C   . GLY B 2 35  ? -32.610 -63.614 19.033  1.00 27.05 ?  35   GLY C C   1 
ATOM   2646 O O   . GLY B 2 35  ? -31.654 -63.501 18.258  1.00 16.75 ?  35   GLY C O   1 
ATOM   2647 N N   . TRP B 2 36  ? -33.887 -63.519 18.652  1.00 22.16 ?  36   TRP C N   1 
ATOM   2648 C CA  . TRP B 2 36  ? -34.285 -62.990 17.354  1.00 17.25 ?  36   TRP C CA  1 
ATOM   2649 C C   . TRP B 2 36  ? -34.888 -61.599 17.544  1.00 14.34 ?  36   TRP C C   1 
ATOM   2650 O O   . TRP B 2 36  ? -35.631 -61.358 18.513  1.00 15.58 ?  36   TRP C O   1 
ATOM   2651 C CB  . TRP B 2 36  ? -35.301 -63.911 16.650  1.00 18.24 ?  36   TRP C CB  1 
ATOM   2652 C CG  . TRP B 2 36  ? -34.625 -65.069 15.939  1.00 19.95 ?  36   TRP C CG  1 
ATOM   2653 C CD1 . TRP B 2 36  ? -34.482 -66.348 16.432  1.00 36.49 ?  36   TRP C CD1 1 
ATOM   2654 C CD2 . TRP B 2 36  ? -34.016 -65.075 14.636  1.00 20.10 ?  36   TRP C CD2 1 
ATOM   2655 N NE1 . TRP B 2 36  ? -33.814 -67.137 15.525  1.00 20.26 ?  36   TRP C NE1 1 
ATOM   2656 C CE2 . TRP B 2 36  ? -33.533 -66.397 14.403  1.00 20.67 ?  36   TRP C CE2 1 
ATOM   2657 C CE3 . TRP B 2 36  ? -33.844 -64.106 13.636  1.00 25.44 ?  36   TRP C CE3 1 
ATOM   2658 C CZ2 . TRP B 2 36  ? -32.878 -66.766 13.219  1.00 20.43 ?  36   TRP C CZ2 1 
ATOM   2659 C CZ3 . TRP B 2 36  ? -33.192 -64.474 12.456  1.00 17.74 ?  36   TRP C CZ3 1 
ATOM   2660 C CH2 . TRP B 2 36  ? -32.702 -65.797 12.258  1.00 19.68 ?  36   TRP C CH2 1 
ATOM   2661 N N   . TYR B 2 37  ? -34.572 -60.687 16.595  1.00 16.02 ?  37   TYR C N   1 
ATOM   2662 C CA  . TYR B 2 37  ? -35.010 -59.289 16.610  1.00 16.27 ?  37   TYR C CA  1 
ATOM   2663 C C   . TYR B 2 37  ? -35.479 -58.920 15.204  1.00 13.11 ?  37   TYR C C   1 
ATOM   2664 O O   . TYR B 2 37  ? -35.173 -59.618 14.232  1.00 15.69 ?  37   TYR C O   1 
ATOM   2665 C CB  . TYR B 2 37  ? -33.850 -58.339 17.045  1.00 12.55 ?  37   TYR C CB  1 
ATOM   2666 C CG  . TYR B 2 37  ? -33.183 -58.785 18.329  1.00 14.76 ?  37   TYR C CG  1 
ATOM   2667 C CD1 . TYR B 2 37  ? -32.288 -59.889 18.340  1.00 13.61 ?  37   TYR C CD1 1 
ATOM   2668 C CD2 . TYR B 2 37  ? -33.487 -58.158 19.535  1.00 14.69 ?  37   TYR C CD2 1 
ATOM   2669 C CE1 . TYR B 2 37  ? -31.727 -60.337 19.549  1.00 14.19 ?  37   TYR C CE1 1 
ATOM   2670 C CE2 . TYR B 2 37  ? -32.915 -58.590 20.735  1.00 14.87 ?  37   TYR C CE2 1 
ATOM   2671 C CZ  . TYR B 2 37  ? -32.056 -59.699 20.716  1.00 15.81 ?  37   TYR C CZ  1 
ATOM   2672 O OH  . TYR B 2 37  ? -31.497 -60.135 21.919  1.00 15.39 ?  37   TYR C OH  1 
ATOM   2673 N N   . ARG B 2 38  ? -36.207 -57.803 15.090  1.00 15.06 ?  38   ARG C N   1 
ATOM   2674 C CA  . ARG B 2 38  ? -36.669 -57.377 13.767  1.00 16.17 ?  38   ARG C CA  1 
ATOM   2675 C C   . ARG B 2 38  ? -36.792 -55.864 13.706  1.00 17.98 ?  38   ARG C C   1 
ATOM   2676 O O   . ARG B 2 38  ? -37.023 -55.191 14.718  1.00 15.96 ?  38   ARG C O   1 
ATOM   2677 C CB  . ARG B 2 38  ? -38.030 -58.043 13.381  1.00 15.02 ?  38   ARG C CB  1 
ATOM   2678 C CG  . ARG B 2 38  ? -39.176 -57.628 14.231  1.00 17.70 ?  38   ARG C CG  1 
ATOM   2679 C CD  . ARG B 2 38  ? -40.463 -58.339 13.802  1.00 19.82 ?  38   ARG C CD  1 
ATOM   2680 N NE  . ARG B 2 38  ? -41.627 -57.741 14.448  1.00 24.95 ?  38   ARG C NE  1 
ATOM   2681 C CZ  . ARG B 2 38  ? -42.851 -58.259 14.354  1.00 27.11 ?  38   ARG C CZ  1 
ATOM   2682 N NH1 . ARG B 2 38  ? -43.082 -59.357 13.640  1.00 25.65 ?  38   ARG C NH1 1 
ATOM   2683 N NH2 . ARG B 2 38  ? -43.863 -57.651 14.966  1.00 25.59 ?  38   ARG C NH2 1 
ATOM   2684 N N   . GLN B 2 39  ? -36.605 -55.318 12.507  1.00 15.89 ?  39   GLN C N   1 
ATOM   2685 C CA  . GLN B 2 39  ? -36.807 -53.876 12.361  1.00 19.75 ?  39   GLN C CA  1 
ATOM   2686 C C   . GLN B 2 39  ? -37.393 -53.587 10.987  1.00 18.69 ?  39   GLN C C   1 
ATOM   2687 O O   . GLN B 2 39  ? -36.846 -54.022 9.969   1.00 19.52 ?  39   GLN C O   1 
ATOM   2688 C CB  . GLN B 2 39  ? -35.487 -53.114 12.530  1.00 19.04 ?  39   GLN C CB  1 
ATOM   2689 C CG  . GLN B 2 39  ? -35.634 -51.591 12.511  1.00 19.38 ?  39   GLN C CG  1 
ATOM   2690 C CD  . GLN B 2 39  ? -34.369 -50.880 12.901  1.00 20.94 ?  39   GLN C CD  1 
ATOM   2691 O OE1 . GLN B 2 39  ? -33.283 -51.369 12.641  1.00 22.43 ?  39   GLN C OE1 1 
ATOM   2692 N NE2 . GLN B 2 39  ? -34.510 -49.698 13.490  1.00 25.89 ?  39   GLN C NE2 1 
ATOM   2693 N N   . ALA B 2 40  ? -38.519 -52.825 10.979  1.00 18.61 ?  40   ALA C N   1 
ATOM   2694 C CA  . ALA B 2 40  ? -39.131 -52.327 9.752   1.00 26.52 ?  40   ALA C CA  1 
ATOM   2695 C C   . ALA B 2 40  ? -38.705 -50.884 9.498   1.00 29.58 ?  40   ALA C C   1 
ATOM   2696 O O   . ALA B 2 40  ? -38.404 -50.143 10.438  1.00 23.57 ?  40   ALA C O   1 
ATOM   2697 C CB  . ALA B 2 40  ? -40.657 -52.404 9.843   1.00 27.30 ?  40   ALA C CB  1 
ATOM   2698 N N   . PRO B 2 41  ? -38.659 -50.453 8.239   1.00 32.19 ?  41   PRO C N   1 
ATOM   2699 C CA  . PRO B 2 41  ? -38.200 -49.087 7.936   1.00 33.11 ?  41   PRO C CA  1 
ATOM   2700 C C   . PRO B 2 41  ? -38.973 -48.037 8.728   1.00 31.30 ?  41   PRO C C   1 
ATOM   2701 O O   . PRO B 2 41  ? -40.201 -48.084 8.825   1.00 28.79 ?  41   PRO C O   1 
ATOM   2702 C CB  . PRO B 2 41  ? -38.460 -48.960 6.429   1.00 40.36 ?  41   PRO C CB  1 
ATOM   2703 C CG  . PRO B 2 41  ? -38.484 -50.397 5.917   1.00 38.16 ?  41   PRO C CG  1 
ATOM   2704 C CD  . PRO B 2 41  ? -39.058 -51.216 7.039   1.00 35.92 ?  41   PRO C CD  1 
ATOM   2705 N N   . GLY B 2 42  ? -38.247 -47.085 9.309   1.00 34.50 ?  42   GLY C N   1 
ATOM   2706 C CA  . GLY B 2 42  ? -38.902 -46.031 10.061  1.00 30.45 ?  42   GLY C CA  1 
ATOM   2707 C C   . GLY B 2 42  ? -39.430 -46.401 11.436  1.00 39.86 ?  42   GLY C C   1 
ATOM   2708 O O   . GLY B 2 42  ? -40.064 -45.561 12.084  1.00 44.09 ?  42   GLY C O   1 
ATOM   2709 N N   . LYS B 2 43  ? -39.198 -47.619 11.910  1.00 30.28 ?  43   LYS C N   1 
ATOM   2710 C CA  . LYS B 2 43  ? -39.653 -48.047 13.226  1.00 30.83 ?  43   LYS C CA  1 
ATOM   2711 C C   . LYS B 2 43  ? -38.467 -48.450 14.097  1.00 21.56 ?  43   LYS C C   1 
ATOM   2712 O O   . LYS B 2 43  ? -37.333 -48.601 13.621  1.00 24.07 ?  43   LYS C O   1 
ATOM   2713 C CB  . LYS B 2 43  ? -40.655 -49.202 13.122  1.00 31.19 ?  43   LYS C CB  1 
ATOM   2714 C CG  . LYS B 2 43  ? -41.713 -48.999 12.041  1.00 37.44 ?  43   LYS C CG  1 
ATOM   2715 C CD  . LYS B 2 43  ? -42.902 -49.886 12.261  1.00 41.89 ?  43   LYS C CD  1 
ATOM   2716 C CE  . LYS B 2 43  ? -44.167 -49.039 12.503  1.00 52.72 ?  43   LYS C CE  1 
ATOM   2717 N NZ  . LYS B 2 43  ? -44.723 -48.341 11.310  1.00 54.13 ?  43   LYS C NZ  1 
ATOM   2718 N N   . GLN B 2 44  ? -38.733 -48.592 15.394  1.00 21.68 ?  44   GLN C N   1 
ATOM   2719 C CA  . GLN B 2 44  ? -37.682 -49.050 16.300  1.00 17.37 ?  44   GLN C CA  1 
ATOM   2720 C C   . GLN B 2 44  ? -37.438 -50.551 16.118  1.00 20.87 ?  44   GLN C C   1 
ATOM   2721 O O   . GLN B 2 44  ? -38.373 -51.325 15.884  1.00 22.10 ?  44   GLN C O   1 
ATOM   2722 C CB  . GLN B 2 44  ? -38.075 -48.782 17.754  1.00 15.61 ?  44   GLN C CB  1 
ATOM   2723 C CG  . GLN B 2 44  ? -38.492 -47.318 18.011  1.00 18.03 ?  44   GLN C CG  1 
ATOM   2724 C CD  . GLN B 2 44  ? -37.289 -46.386 18.132  1.00 17.18 ?  44   GLN C CD  1 
ATOM   2725 O OE1 . GLN B 2 44  ? -36.159 -46.805 17.918  1.00 14.95 ?  44   GLN C OE1 1 
ATOM   2726 N NE2 . GLN B 2 44  ? -37.537 -45.124 18.444  1.00 15.56 ?  44   GLN C NE2 1 
ATOM   2727 N N   . ARG B 2 45  ? -36.175 -50.959 16.276  1.00 18.93 ?  45   ARG C N   1 
ATOM   2728 C CA  . ARG B 2 45  ? -35.830 -52.377 16.293  1.00 18.66 ?  45   ARG C CA  1 
ATOM   2729 C C   . ARG B 2 45  ? -36.423 -53.020 17.555  1.00 19.07 ?  45   ARG C C   1 
ATOM   2730 O O   . ARG B 2 45  ? -36.420 -52.424 18.638  1.00 21.57 ?  45   ARG C O   1 
ATOM   2731 C CB  . ARG B 2 45  ? -34.300 -52.545 16.266  1.00 16.15 ?  45   ARG C CB  1 
ATOM   2732 C CG  . ARG B 2 45  ? -33.844 -54.050 16.291  1.00 15.83 ?  45   ARG C CG  1 
ATOM   2733 C CD  . ARG B 2 45  ? -32.571 -54.371 15.504  1.00 20.41 ?  45   ARG C CD  1 
ATOM   2734 N NE  . ARG B 2 45  ? -31.559 -53.342 15.608  1.00 26.46 ?  45   ARG C NE  1 
ATOM   2735 C CZ  . ARG B 2 45  ? -30.551 -53.165 14.767  1.00 24.56 ?  45   ARG C CZ  1 
ATOM   2736 N NH1 . ARG B 2 45  ? -30.348 -53.987 13.735  1.00 19.03 ?  45   ARG C NH1 1 
ATOM   2737 N NH2 . ARG B 2 45  ? -29.724 -52.132 14.967  1.00 26.42 ?  45   ARG C NH2 1 
ATOM   2738 N N   . GLU B 2 46  ? -36.974 -54.234 17.427  1.00 18.90 ?  46   GLU C N   1 
ATOM   2739 C CA  . GLU B 2 46  ? -37.658 -54.838 18.562  1.00 18.55 ?  46   GLU C CA  1 
ATOM   2740 C C   . GLU B 2 46  ? -37.314 -56.321 18.663  1.00 17.00 ?  46   GLU C C   1 
ATOM   2741 O O   . GLU B 2 46  ? -36.999 -56.987 17.669  1.00 18.47 ?  46   GLU C O   1 
ATOM   2742 C CB  . GLU B 2 46  ? -39.180 -54.653 18.484  1.00 21.38 ?  46   GLU C CB  1 
ATOM   2743 C CG  . GLU B 2 46  ? -39.821 -55.313 17.277  1.00 21.33 ?  46   GLU C CG  1 
ATOM   2744 C CD  . GLU B 2 46  ? -41.294 -54.948 17.107  1.00 25.38 ?  46   GLU C CD  1 
ATOM   2745 O OE1 . GLU B 2 46  ? -41.816 -54.172 17.936  1.00 29.13 ?  46   GLU C OE1 1 
ATOM   2746 O OE2 . GLU B 2 46  ? -41.921 -55.420 16.130  1.00 26.35 -1 46   GLU C OE2 1 
ATOM   2747 N N   . TRP B 2 47  ? -37.355 -56.817 19.896  1.00 17.14 ?  47   TRP C N   1 
ATOM   2748 C CA  . TRP B 2 47  ? -37.077 -58.212 20.197  1.00 14.59 ?  47   TRP C CA  1 
ATOM   2749 C C   . TRP B 2 47  ? -38.303 -59.076 19.887  1.00 15.72 ?  47   TRP C C   1 
ATOM   2750 O O   . TRP B 2 47  ? -39.442 -58.647 20.091  1.00 18.04 ?  47   TRP C O   1 
ATOM   2751 C CB  . TRP B 2 47  ? -36.711 -58.342 21.692  1.00 15.33 ?  47   TRP C CB  1 
ATOM   2752 C CG  . TRP B 2 47  ? -36.609 -59.761 22.206  1.00 15.45 ?  47   TRP C CG  1 
ATOM   2753 C CD1 . TRP B 2 47  ? -35.587 -60.661 21.990  1.00 17.09 ?  47   TRP C CD1 1 
ATOM   2754 C CD2 . TRP B 2 47  ? -37.554 -60.410 23.060  1.00 16.38 ?  47   TRP C CD2 1 
ATOM   2755 N NE1 . TRP B 2 47  ? -35.858 -61.851 22.659  1.00 17.72 ?  47   TRP C NE1 1 
ATOM   2756 C CE2 . TRP B 2 47  ? -37.059 -61.716 23.315  1.00 16.44 ?  47   TRP C CE2 1 
ATOM   2757 C CE3 . TRP B 2 47  ? -38.768 -60.012 23.640  1.00 18.12 ?  47   TRP C CE3 1 
ATOM   2758 C CZ2 . TRP B 2 47  ? -37.752 -62.627 24.118  1.00 18.92 ?  47   TRP C CZ2 1 
ATOM   2759 C CZ3 . TRP B 2 47  ? -39.474 -60.941 24.429  1.00 19.30 ?  47   TRP C CZ3 1 
ATOM   2760 C CH2 . TRP B 2 47  ? -38.950 -62.212 24.669  1.00 16.35 ?  47   TRP C CH2 1 
ATOM   2761 N N   . VAL B 2 48  ? -38.049 -60.316 19.430  1.00 16.78 ?  48   VAL C N   1 
ATOM   2762 C CA  . VAL B 2 48  ? -39.081 -61.243 18.958  1.00 17.11 ?  48   VAL C CA  1 
ATOM   2763 C C   . VAL B 2 48  ? -39.144 -62.502 19.829  1.00 17.86 ?  48   VAL C C   1 
ATOM   2764 O O   . VAL B 2 48  ? -40.226 -62.931 20.243  1.00 17.02 ?  48   VAL C O   1 
ATOM   2765 C CB  . VAL B 2 48  ? -38.851 -61.619 17.474  1.00 17.34 ?  48   VAL C CB  1 
ATOM   2766 C CG1 . VAL B 2 48  ? -39.798 -62.746 17.033  1.00 25.83 ?  48   VAL C CG1 1 
ATOM   2767 C CG2 . VAL B 2 48  ? -38.962 -60.385 16.544  1.00 18.43 ?  48   VAL C CG2 1 
ATOM   2768 N N   . ALA B 2 49  ? -37.998 -63.112 20.109  1.00 16.01 ?  49   ALA C N   1 
ATOM   2769 C CA  . ALA B 2 49  ? -37.943 -64.421 20.757  1.00 19.74 ?  49   ALA C CA  1 
ATOM   2770 C C   . ALA B 2 49  ? -36.558 -64.629 21.365  1.00 19.65 ?  49   ALA C C   1 
ATOM   2771 O O   . ALA B 2 49  ? -35.552 -64.160 20.814  1.00 18.30 ?  49   ALA C O   1 
ATOM   2772 C CB  . ALA B 2 49  ? -38.229 -65.535 19.748  1.00 19.39 ?  49   ALA C CB  1 
ATOM   2773 N N   . GLY B 2 50  ? -36.497 -65.397 22.455  1.00 19.07 ?  50   GLY C N   1 
ATOM   2774 C CA  . GLY B 2 50  ? -35.227 -65.699 23.094  1.00 16.58 ?  50   GLY C CA  1 
ATOM   2775 C C   . GLY B 2 50  ? -35.159 -67.156 23.514  1.00 20.72 ?  50   GLY C C   1 
ATOM   2776 O O   . GLY B 2 50  ? -36.189 -67.794 23.768  1.00 18.25 ?  50   GLY C O   1 
ATOM   2777 N N   . ILE B 2 51  ? -33.932 -67.680 23.589  1.00 19.55 ?  51   ILE C N   1 
ATOM   2778 C CA  . ILE B 2 51  ? -33.699 -69.064 23.999  1.00 23.10 ?  51   ILE C CA  1 
ATOM   2779 C C   . ILE B 2 51  ? -32.460 -69.123 24.889  1.00 23.05 ?  51   ILE C C   1 
ATOM   2780 O O   . ILE B 2 51  ? -31.410 -68.563 24.542  1.00 21.73 ?  51   ILE C O   1 
ATOM   2781 C CB  . ILE B 2 51  ? -33.548 -69.983 22.774  1.00 24.41 ?  51   ILE C CB  1 
ATOM   2782 C CG1 . ILE B 2 51  ? -33.650 -71.467 23.195  1.00 24.70 ?  51   ILE C CG1 1 
ATOM   2783 C CG2 . ILE B 2 51  ? -32.254 -69.675 22.005  1.00 21.60 ?  51   ILE C CG2 1 
ATOM   2784 C CD1 . ILE B 2 51  ? -33.883 -72.407 22.017  1.00 26.27 ?  51   ILE C CD1 1 
ATOM   2785 N N   . THR B 2 52  ? -32.567 -69.817 26.029  1.00 22.27 ?  52   THR C N   1 
ATOM   2786 C CA  . THR B 2 52  ? -31.437 -69.984 26.946  1.00 23.40 ?  52   THR C CA  1 
ATOM   2787 C C   . THR B 2 52  ? -30.524 -71.107 26.467  1.00 26.54 ?  52   THR C C   1 
ATOM   2788 O O   . THR B 2 52  ? -30.879 -71.892 25.585  1.00 24.88 ?  52   THR C O   1 
ATOM   2789 C CB  . THR B 2 52  ? -31.910 -70.316 28.377  1.00 26.88 ?  52   THR C CB  1 
ATOM   2790 O OG1 . THR B 2 52  ? -32.445 -71.654 28.410  1.00 25.06 ?  52   THR C OG1 1 
ATOM   2791 C CG2 . THR B 2 52  ? -32.990 -69.340 28.874  1.00 23.59 ?  52   THR C CG2 1 
ATOM   2792 N N   . SER B 2 53  ? -29.333 -71.188 27.078  1.00 23.19 ?  53   SER C N   1 
ATOM   2793 C CA  . SER B 2 53  ? -28.450 -72.322 26.806  1.00 27.00 ?  53   SER C CA  1 
ATOM   2794 C C   . SER B 2 53  ? -29.119 -73.641 27.178  1.00 30.39 ?  53   SER C C   1 
ATOM   2795 O O   . SER B 2 53  ? -28.748 -74.686 26.633  1.00 29.38 ?  53   SER C O   1 
ATOM   2796 C CB  . SER B 2 53  ? -27.119 -72.217 27.570  1.00 31.18 ?  53   SER C CB  1 
ATOM   2797 O OG  . SER B 2 53  ? -27.305 -71.916 28.936  1.00 34.96 ?  53   SER C OG  1 
ATOM   2798 N N   . GLY B 2 54  ? -30.091 -73.608 28.092  1.00 28.46 ?  54   GLY C N   1 
ATOM   2799 C CA  . GLY B 2 54  ? -30.922 -74.754 28.422  1.00 34.16 ?  54   GLY C CA  1 
ATOM   2800 C C   . GLY B 2 54  ? -32.078 -75.026 27.477  1.00 37.15 ?  54   GLY C C   1 
ATOM   2801 O O   . GLY B 2 54  ? -32.841 -75.972 27.703  1.00 32.35 ?  54   GLY C O   1 
ATOM   2802 N N   . SER B 2 55  ? -32.241 -74.219 26.422  1.00 33.35 ?  55   SER C N   1 
ATOM   2803 C CA  . SER B 2 55  ? -33.274 -74.391 25.396  1.00 32.14 ?  55   SER C CA  1 
ATOM   2804 C C   . SER B 2 55  ? -34.681 -74.055 25.887  1.00 34.05 ?  55   SER C C   1 
ATOM   2805 O O   . SER B 2 55  ? -35.670 -74.448 25.255  1.00 31.13 ?  55   SER C O   1 
ATOM   2806 C CB  . SER B 2 55  ? -33.251 -75.800 24.787  1.00 35.08 ?  55   SER C CB  1 
ATOM   2807 O OG  . SER B 2 55  ? -32.059 -76.002 24.049  1.00 31.97 ?  55   SER C OG  1 
ATOM   2808 N N   . SER B 2 56  ? -34.791 -73.309 26.975  1.00 30.13 ?  56   SER C N   1 
ATOM   2809 C CA  . SER B 2 56  ? -36.060 -72.720 27.370  1.00 37.28 ?  56   SER C CA  1 
ATOM   2810 C C   . SER B 2 56  ? -36.340 -71.497 26.502  1.00 48.37 ?  56   SER C C   1 
ATOM   2811 O O   . SER B 2 56  ? -35.415 -70.759 26.133  1.00 31.89 ?  56   SER C O   1 
ATOM   2812 C CB  . SER B 2 56  ? -36.018 -72.320 28.843  1.00 45.85 ?  56   SER C CB  1 
ATOM   2813 O OG  . SER B 2 56  ? -35.676 -73.430 29.650  1.00 57.21 ?  56   SER C OG  1 
ATOM   2814 N N   . THR B 2 57  ? -37.612 -71.278 26.179  1.00 64.72 ?  57   THR C N   1 
ATOM   2815 C CA  . THR B 2 57  ? -37.983 -70.239 25.234  1.00 53.53 ?  57   THR C CA  1 
ATOM   2816 C C   . THR B 2 57  ? -38.922 -69.212 25.862  1.00 54.06 ?  57   THR C C   1 
ATOM   2817 O O   . THR B 2 57  ? -39.592 -69.470 26.863  1.00 64.66 ?  57   THR C O   1 
ATOM   2818 C CB  . THR B 2 57  ? -38.642 -70.837 23.989  1.00 41.91 ?  57   THR C CB  1 
ATOM   2819 O OG1 . THR B 2 57  ? -39.876 -71.455 24.363  1.00 49.14 ?  57   THR C OG1 1 
ATOM   2820 C CG2 . THR B 2 57  ? -37.725 -71.850 23.329  1.00 33.82 ?  57   THR C CG2 1 
ATOM   2821 N N   . ILE B 2 58  ? -38.959 -68.038 25.233  1.00 30.88 ?  58   ILE C N   1 
ATOM   2822 C CA  . ILE B 2 58  ? -39.790 -66.910 25.645  1.00 26.91 ?  58   ILE C CA  1 
ATOM   2823 C C   . ILE B 2 58  ? -40.005 -66.017 24.427  1.00 24.72 ?  58   ILE C C   1 
ATOM   2824 O O   . ILE B 2 58  ? -39.118 -65.889 23.582  1.00 20.72 ?  58   ILE C O   1 
ATOM   2825 C CB  . ILE B 2 58  ? -39.151 -66.157 26.843  1.00 27.72 ?  58   ILE C CB  1 
ATOM   2826 C CG1 . ILE B 2 58  ? -40.182 -65.279 27.543  1.00 32.98 ?  58   ILE C CG1 1 
ATOM   2827 C CG2 . ILE B 2 58  ? -37.786 -65.454 26.480  1.00 24.99 ?  58   ILE C CG2 1 
ATOM   2828 C CD1 . ILE B 2 58  ? -39.599 -64.530 28.729  1.00 32.27 ?  58   ILE C CD1 1 
ATOM   2829 N N   . TYR B 2 59  ? -41.196 -65.427 24.321  1.00 21.00 ?  59   TYR C N   1 
ATOM   2830 C CA  . TYR B 2 59  ? -41.611 -64.727 23.107  1.00 25.03 ?  59   TYR C CA  1 
ATOM   2831 C C   . TYR B 2 59  ? -42.158 -63.346 23.426  1.00 21.86 ?  59   TYR C C   1 
ATOM   2832 O O   . TYR B 2 59  ? -42.663 -63.094 24.522  1.00 24.69 ?  59   TYR C O   1 
ATOM   2833 C CB  . TYR B 2 59  ? -42.681 -65.544 22.339  1.00 25.79 ?  59   TYR C CB  1 
ATOM   2834 C CG  . TYR B 2 59  ? -42.141 -66.898 21.908  1.00 24.96 ?  59   TYR C CG  1 
ATOM   2835 C CD1 . TYR B 2 59  ? -41.460 -67.038 20.698  1.00 22.57 ?  59   TYR C CD1 1 
ATOM   2836 C CD2 . TYR B 2 59  ? -42.270 -68.030 22.734  1.00 27.02 ?  59   TYR C CD2 1 
ATOM   2837 C CE1 . TYR B 2 59  ? -40.924 -68.248 20.311  1.00 26.28 ?  59   TYR C CE1 1 
ATOM   2838 C CE2 . TYR B 2 59  ? -41.732 -69.263 22.343  1.00 29.40 ?  59   TYR C CE2 1 
ATOM   2839 C CZ  . TYR B 2 59  ? -41.064 -69.365 21.123  1.00 29.91 ?  59   TYR C CZ  1 
ATOM   2840 O OH  . TYR B 2 59  ? -40.515 -70.564 20.701  1.00 25.98 ?  59   TYR C OH  1 
ATOM   2841 N N   . ALA B 2 60  ? -42.055 -62.442 22.451  1.00 20.91 ?  60   ALA C N   1 
ATOM   2842 C CA  . ALA B 2 60  ? -42.694 -61.143 22.593  1.00 27.86 ?  60   ALA C CA  1 
ATOM   2843 C C   . ALA B 2 60  ? -44.214 -61.276 22.547  1.00 40.02 ?  60   ALA C C   1 
ATOM   2844 O O   . ALA B 2 60  ? -44.764 -62.260 22.042  1.00 32.03 ?  60   ALA C O   1 
ATOM   2845 C CB  . ALA B 2 60  ? -42.239 -60.184 21.486  1.00 29.50 ?  60   ALA C CB  1 
ATOM   2846 N N   . ASP B 2 61  ? -44.896 -60.238 23.039  1.00 50.18 ?  61   ASP C N   1 
ATOM   2847 C CA  . ASP B 2 61  ? -46.354 -60.272 23.126  1.00 60.01 ?  61   ASP C CA  1 
ATOM   2848 C C   . ASP B 2 61  ? -47.018 -60.456 21.766  1.00 57.68 ?  61   ASP C C   1 
ATOM   2849 O O   . ASP B 2 61  ? -48.103 -61.039 21.688  1.00 63.95 ?  61   ASP C O   1 
ATOM   2850 C CB  . ASP B 2 61  ? -46.876 -58.996 23.787  1.00 66.26 ?  61   ASP C CB  1 
ATOM   2851 C CG  . ASP B 2 61  ? -46.330 -57.731 23.141  1.00 71.30 ?  61   ASP C CG  1 
ATOM   2852 O OD1 . ASP B 2 61  ? -45.686 -57.822 22.078  1.00 74.03 ?  61   ASP C OD1 1 
ATOM   2853 O OD2 . ASP B 2 61  ? -46.551 -56.637 23.698  1.00 73.91 -1 61   ASP C OD2 1 
ATOM   2854 N N   . PHE B 2 62  ? -46.403 -59.967 20.690  1.00 52.95 ?  62   PHE C N   1 
ATOM   2855 C CA  . PHE B 2 62  ? -47.060 -60.019 19.389  1.00 55.38 ?  62   PHE C CA  1 
ATOM   2856 C C   . PHE B 2 62  ? -46.894 -61.359 18.691  1.00 49.08 ?  62   PHE C C   1 
ATOM   2857 O O   . PHE B 2 62  ? -47.515 -61.567 17.643  1.00 43.98 ?  62   PHE C O   1 
ATOM   2858 C CB  . PHE B 2 62  ? -46.547 -58.894 18.478  1.00 64.92 ?  62   PHE C CB  1 
ATOM   2859 C CG  . PHE B 2 62  ? -45.052 -58.866 18.309  1.00 59.57 ?  62   PHE C CG  1 
ATOM   2860 C CD1 . PHE B 2 62  ? -44.392 -59.844 17.576  1.00 42.17 ?  62   PHE C CD1 1 
ATOM   2861 C CD2 . PHE B 2 62  ? -44.305 -57.863 18.904  1.00 52.72 ?  62   PHE C CD2 1 
ATOM   2862 C CE1 . PHE B 2 62  ? -43.008 -59.809 17.421  1.00 38.66 ?  62   PHE C CE1 1 
ATOM   2863 C CE2 . PHE B 2 62  ? -42.932 -57.812 18.760  1.00 35.91 ?  62   PHE C CE2 1 
ATOM   2864 C CZ  . PHE B 2 62  ? -42.274 -58.787 18.025  1.00 30.23 ?  62   PHE C CZ  1 
ATOM   2865 N N   . VAL B 2 63  ? -46.077 -62.265 19.232  1.00 48.67 ?  63   VAL C N   1 
ATOM   2866 C CA  . VAL B 2 63  ? -45.891 -63.562 18.590  1.00 45.34 ?  63   VAL C CA  1 
ATOM   2867 C C   . VAL B 2 63  ? -47.155 -64.399 18.712  1.00 52.17 ?  63   VAL C C   1 
ATOM   2868 O O   . VAL B 2 63  ? -47.645 -64.953 17.723  1.00 40.83 ?  63   VAL C O   1 
ATOM   2869 C CB  . VAL B 2 63  ? -44.669 -64.291 19.175  1.00 44.29 ?  63   VAL C CB  1 
ATOM   2870 C CG1 . VAL B 2 63  ? -44.613 -65.726 18.655  1.00 37.96 ?  63   VAL C CG1 1 
ATOM   2871 C CG2 . VAL B 2 63  ? -43.395 -63.536 18.812  1.00 34.92 ?  63   VAL C CG2 1 
ATOM   2872 N N   . LYS B 2 64  ? -47.703 -64.502 19.922  1.00 52.26 ?  64   LYS C N   1 
ATOM   2873 C CA  . LYS B 2 64  ? -49.007 -65.131 20.141  1.00 47.97 ?  64   LYS C CA  1 
ATOM   2874 C C   . LYS B 2 64  ? -49.038 -66.558 19.583  1.00 42.52 ?  64   LYS C C   1 
ATOM   2875 O O   . LYS B 2 64  ? -49.955 -66.948 18.855  1.00 40.67 ?  64   LYS C O   1 
ATOM   2876 C CB  . LYS B 2 64  ? -50.124 -64.271 19.538  1.00 51.61 ?  64   LYS C CB  1 
ATOM   2877 C CG  . LYS B 2 64  ? -50.419 -62.976 20.291  1.00 54.02 ?  64   LYS C CG  1 
ATOM   2878 C CD  . LYS B 2 64  ? -51.116 -61.968 19.380  1.00 60.58 ?  64   LYS C CD  1 
ATOM   2879 C CE  . LYS B 2 64  ? -51.608 -60.732 20.134  1.00 60.00 ?  64   LYS C CE  1 
ATOM   2880 N NZ  . LYS B 2 64  ? -51.904 -61.001 21.570  1.00 60.95 ?  64   LYS C NZ  1 
ATOM   2881 N N   . GLY B 2 65  ? -48.013 -67.338 19.931  1.00 38.59 ?  65   GLY C N   1 
ATOM   2882 C CA  . GLY B 2 65  ? -47.932 -68.750 19.619  1.00 37.40 ?  65   GLY C CA  1 
ATOM   2883 C C   . GLY B 2 65  ? -47.604 -69.095 18.186  1.00 39.51 ?  65   GLY C C   1 
ATOM   2884 O O   . GLY B 2 65  ? -47.595 -70.281 17.840  1.00 38.08 ?  65   GLY C O   1 
ATOM   2885 N N   . ARG B 2 66  ? -47.315 -68.112 17.335  1.00 31.42 ?  66   ARG C N   1 
ATOM   2886 C CA  . ARG B 2 66  ? -47.138 -68.386 15.916  1.00 34.89 ?  66   ARG C CA  1 
ATOM   2887 C C   . ARG B 2 66  ? -45.704 -68.704 15.520  1.00 36.25 ?  66   ARG C C   1 
ATOM   2888 O O   . ARG B 2 66  ? -45.503 -69.287 14.451  1.00 28.22 ?  66   ARG C O   1 
ATOM   2889 C CB  . ARG B 2 66  ? -47.610 -67.198 15.074  1.00 35.59 ?  66   ARG C CB  1 
ATOM   2890 C CG  . ARG B 2 66  ? -49.027 -66.733 15.384  1.00 34.66 ?  66   ARG C CG  1 
ATOM   2891 C CD  . ARG B 2 66  ? -49.356 -65.463 14.625  1.00 35.81 ?  66   ARG C CD  1 
ATOM   2892 N NE  . ARG B 2 66  ? -48.587 -64.308 15.094  1.00 34.43 ?  66   ARG C NE  1 
ATOM   2893 C CZ  . ARG B 2 66  ? -47.961 -63.465 14.285  1.00 35.67 ?  66   ARG C CZ  1 
ATOM   2894 N NH1 . ARG B 2 66  ? -47.991 -63.621 12.970  1.00 30.27 ?  66   ARG C NH1 1 
ATOM   2895 N NH2 . ARG B 2 66  ? -47.292 -62.439 14.807  1.00 32.76 ?  66   ARG C NH2 1 
ATOM   2896 N N   . PHE B 2 67  ? -44.709 -68.281 16.306  1.00 35.16 ?  67   PHE C N   1 
ATOM   2897 C CA  . PHE B 2 67  ? -43.300 -68.519 16.013  1.00 36.80 ?  67   PHE C CA  1 
ATOM   2898 C C   . PHE B 2 67  ? -42.686 -69.441 17.059  1.00 31.17 ?  67   PHE C C   1 
ATOM   2899 O O   . PHE B 2 67  ? -43.095 -69.451 18.220  1.00 36.17 ?  67   PHE C O   1 
ATOM   2900 C CB  . PHE B 2 67  ? -42.475 -67.222 15.990  1.00 55.69 ?  67   PHE C CB  1 
ATOM   2901 C CG  . PHE B 2 67  ? -43.000 -66.136 15.089  1.00 45.04 ?  67   PHE C CG  1 
ATOM   2902 C CD1 . PHE B 2 67  ? -43.988 -66.365 14.152  1.00 38.70 ?  67   PHE C CD1 1 
ATOM   2903 C CD2 . PHE B 2 67  ? -42.519 -64.841 15.233  1.00 56.54 ?  67   PHE C CD2 1 
ATOM   2904 C CE1 . PHE B 2 67  ? -44.462 -65.333 13.349  1.00 36.36 ?  67   PHE C CE1 1 
ATOM   2905 C CE2 . PHE B 2 67  ? -42.985 -63.809 14.448  1.00 39.16 ?  67   PHE C CE2 1 
ATOM   2906 C CZ  . PHE B 2 67  ? -43.956 -64.046 13.499  1.00 40.35 ?  67   PHE C CZ  1 
ATOM   2907 N N   . THR B 2 68  ? -41.684 -70.208 16.629  1.00 29.88 ?  68   THR C N   1 
ATOM   2908 C CA  . THR B 2 68  ? -40.937 -71.114 17.492  1.00 34.16 ?  68   THR C CA  1 
ATOM   2909 C C   . THR B 2 68  ? -39.448 -70.883 17.291  1.00 29.48 ?  68   THR C C   1 
ATOM   2910 O O   . THR B 2 68  ? -38.950 -71.012 16.168  1.00 27.79 ?  68   THR C O   1 
ATOM   2911 C CB  . THR B 2 68  ? -41.270 -72.569 17.175  1.00 31.15 ?  68   THR C CB  1 
ATOM   2912 O OG1 . THR B 2 68  ? -42.693 -72.727 17.188  1.00 29.39 ?  68   THR C OG1 1 
ATOM   2913 C CG2 . THR B 2 68  ? -40.600 -73.506 18.204  1.00 29.34 ?  68   THR C CG2 1 
ATOM   2914 N N   . ILE B 2 69  ? -38.742 -70.558 18.376  1.00 22.60 ?  69   ILE C N   1 
ATOM   2915 C CA  . ILE B 2 69  ? -37.286 -70.444 18.359  1.00 31.16 ?  69   ILE C CA  1 
ATOM   2916 C C   . ILE B 2 69  ? -36.726 -71.758 18.864  1.00 31.36 ?  69   ILE C C   1 
ATOM   2917 O O   . ILE B 2 69  ? -37.269 -72.365 19.795  1.00 38.14 ?  69   ILE C O   1 
ATOM   2918 C CB  . ILE B 2 69  ? -36.773 -69.249 19.200  1.00 24.36 ?  69   ILE C CB  1 
ATOM   2919 C CG1 . ILE B 2 69  ? -35.248 -69.069 19.049  1.00 23.26 ?  69   ILE C CG1 1 
ATOM   2920 C CG2 . ILE B 2 69  ? -37.114 -69.385 20.676  1.00 28.08 ?  69   ILE C CG2 1 
ATOM   2921 C CD1 . ILE B 2 69  ? -34.759 -67.751 19.740  1.00 22.71 ?  69   ILE C CD1 1 
ATOM   2922 N N   . SER B 2 70  ? -35.656 -72.211 18.224  1.00 27.01 ?  70   SER C N   1 
ATOM   2923 C CA  . SER B 2 70  ? -34.957 -73.415 18.643  1.00 30.60 ?  70   SER C CA  1 
ATOM   2924 C C   . SER B 2 70  ? -33.484 -73.228 18.323  1.00 29.89 ?  70   SER C C   1 
ATOM   2925 O O   . SER B 2 70  ? -33.085 -72.244 17.685  1.00 23.95 ?  70   SER C O   1 
ATOM   2926 C CB  . SER B 2 70  ? -35.530 -74.666 17.945  1.00 27.52 ?  70   SER C CB  1 
ATOM   2927 O OG  . SER B 2 70  ? -35.495 -74.506 16.540  1.00 27.68 ?  70   SER C OG  1 
ATOM   2928 N N   . ARG B 2 71  ? -32.677 -74.205 18.735  1.00 26.70 ?  71   ARG C N   1 
ATOM   2929 C CA  . ARG B 2 71  ? -31.240 -74.177 18.527  1.00 32.03 ?  71   ARG C CA  1 
ATOM   2930 C C   . ARG B 2 71  ? -30.758 -75.590 18.234  1.00 46.95 ?  71   ARG C C   1 
ATOM   2931 O O   . ARG B 2 71  ? -31.356 -76.571 18.688  1.00 35.87 ?  71   ARG C O   1 
ATOM   2932 C CB  . ARG B 2 71  ? -30.511 -73.621 19.761  1.00 32.71 ?  71   ARG C CB  1 
ATOM   2933 C CG  . ARG B 2 71  ? -30.747 -74.423 21.060  1.00 30.14 ?  71   ARG C CG  1 
ATOM   2934 C CD  . ARG B 2 71  ? -30.271 -73.661 22.305  1.00 29.32 ?  71   ARG C CD  1 
ATOM   2935 N NE  . ARG B 2 71  ? -28.839 -73.369 22.240  1.00 31.72 ?  71   ARG C NE  1 
ATOM   2936 C CZ  . ARG B 2 71  ? -28.252 -72.303 22.773  1.00 31.24 ?  71   ARG C CZ  1 
ATOM   2937 N NH1 . ARG B 2 71  ? -28.943 -71.392 23.456  1.00 24.88 ?  71   ARG C NH1 1 
ATOM   2938 N NH2 . ARG B 2 71  ? -26.945 -72.132 22.598  1.00 25.59 ?  71   ARG C NH2 1 
ATOM   2939 N N   . ASP B 2 72  ? -29.674 -75.678 17.463  1.00 55.22 ?  72   ASP C N   1 
ATOM   2940 C CA  . ASP B 2 72  ? -28.940 -76.916 17.193  1.00 46.70 ?  72   ASP C CA  1 
ATOM   2941 C C   . ASP B 2 72  ? -27.486 -76.653 17.578  1.00 44.56 ?  72   ASP C C   1 
ATOM   2942 O O   . ASP B 2 72  ? -26.737 -76.116 16.763  1.00 39.64 ?  72   ASP C O   1 
ATOM   2943 C CB  . ASP B 2 72  ? -29.063 -77.311 15.723  1.00 45.06 ?  72   ASP C CB  1 
ATOM   2944 C CG  . ASP B 2 72  ? -28.442 -78.676 15.415  1.00 49.69 ?  72   ASP C CG  1 
ATOM   2945 O OD1 . ASP B 2 72  ? -27.515 -79.102 16.140  1.00 48.26 -1 72   ASP C OD1 1 
ATOM   2946 O OD2 . ASP B 2 72  ? -28.848 -79.284 14.399  1.00 47.43 ?  72   ASP C OD2 1 
ATOM   2947 N N   . ASN B 2 73  ? -27.099 -77.009 18.808  1.00 43.93 ?  73   ASN C N   1 
ATOM   2948 C CA  . ASN B 2 73  ? -25.726 -76.765 19.249  1.00 47.86 ?  73   ASN C CA  1 
ATOM   2949 C C   . ASN B 2 73  ? -24.710 -77.446 18.355  1.00 49.55 ?  73   ASN C C   1 
ATOM   2950 O O   . ASN B 2 73  ? -23.615 -76.912 18.142  1.00 54.72 ?  73   ASN C O   1 
ATOM   2951 C CB  . ASN B 2 73  ? -25.531 -77.234 20.682  1.00 46.08 ?  73   ASN C CB  1 
ATOM   2952 C CG  . ASN B 2 73  ? -26.227 -76.351 21.668  1.00 45.59 ?  73   ASN C CG  1 
ATOM   2953 O OD1 . ASN B 2 73  ? -26.933 -75.420 21.289  1.00 43.78 ?  73   ASN C OD1 1 
ATOM   2954 N ND2 . ASN B 2 73  ? -26.043 -76.636 22.947  1.00 45.29 ?  73   ASN C ND2 1 
ATOM   2955 N N   . ALA B 2 74  ? -25.054 -78.621 17.829  1.00 50.12 ?  74   ALA C N   1 
ATOM   2956 C CA  . ALA B 2 74  ? -24.128 -79.352 16.972  1.00 53.15 ?  74   ALA C CA  1 
ATOM   2957 C C   . ALA B 2 74  ? -23.705 -78.519 15.771  1.00 49.18 ?  74   ALA C C   1 
ATOM   2958 O O   . ALA B 2 74  ? -22.546 -78.569 15.352  1.00 52.82 ?  74   ALA C O   1 
ATOM   2959 C CB  . ALA B 2 74  ? -24.770 -80.661 16.518  1.00 50.42 ?  74   ALA C CB  1 
ATOM   2960 N N   . LYS B 2 75  ? -24.631 -77.749 15.206  1.00 45.66 ?  75   LYS C N   1 
ATOM   2961 C CA  . LYS B 2 75  ? -24.379 -76.932 14.026  1.00 49.71 ?  75   LYS C CA  1 
ATOM   2962 C C   . LYS B 2 75  ? -24.230 -75.440 14.323  1.00 44.55 ?  75   LYS C C   1 
ATOM   2963 O O   . LYS B 2 75  ? -24.105 -74.652 13.382  1.00 36.48 ?  75   LYS C O   1 
ATOM   2964 C CB  . LYS B 2 75  ? -25.502 -77.123 13.003  1.00 46.03 ?  75   LYS C CB  1 
ATOM   2965 C CG  . LYS B 2 75  ? -25.788 -78.550 12.628  1.00 47.06 ?  75   LYS C CG  1 
ATOM   2966 C CD  . LYS B 2 75  ? -27.079 -78.607 11.846  1.00 48.79 ?  75   LYS C CD  1 
ATOM   2967 C CE  . LYS B 2 75  ? -27.076 -79.774 10.882  1.00 51.63 ?  75   LYS C CE  1 
ATOM   2968 N NZ  . LYS B 2 75  ? -28.360 -80.508 10.959  1.00 57.45 ?  75   LYS C NZ  1 
ATOM   2969 N N   . ASN B 2 76  ? -24.261 -75.023 15.585  1.00 46.72 ?  76   ASN C N   1 
ATOM   2970 C CA  . ASN B 2 76  ? -24.076 -73.610 15.911  1.00 45.70 ?  76   ASN C CA  1 
ATOM   2971 C C   . ASN B 2 76  ? -25.116 -72.738 15.212  1.00 40.42 ?  76   ASN C C   1 
ATOM   2972 O O   . ASN B 2 76  ? -24.806 -71.654 14.719  1.00 31.00 ?  76   ASN C O   1 
ATOM   2973 C CB  . ASN B 2 76  ? -22.663 -73.158 15.546  1.00 46.88 ?  76   ASN C CB  1 
ATOM   2974 C CG  . ASN B 2 76  ? -21.652 -73.529 16.596  1.00 61.21 ?  76   ASN C CG  1 
ATOM   2975 O OD1 . ASN B 2 76  ? -21.715 -74.611 17.172  1.00 62.64 ?  76   ASN C OD1 1 
ATOM   2976 N ND2 . ASN B 2 76  ? -20.689 -72.651 16.827  1.00 55.07 ?  76   ASN C ND2 1 
ATOM   2977 N N   . THR B 2 77  ? -26.361 -73.209 15.173  1.00 34.38 ?  77   THR C N   1 
ATOM   2978 C CA  . THR B 2 77  ? -27.435 -72.560 14.427  1.00 35.51 ?  77   THR C CA  1 
ATOM   2979 C C   . THR B 2 77  ? -28.643 -72.317 15.320  1.00 38.63 ?  77   THR C C   1 
ATOM   2980 O O   . THR B 2 77  ? -29.009 -73.170 16.135  1.00 45.12 ?  77   THR C O   1 
ATOM   2981 C CB  . THR B 2 77  ? -27.858 -73.406 13.203  1.00 35.44 ?  77   THR C CB  1 
ATOM   2982 O OG1 . THR B 2 77  ? -26.713 -73.655 12.393  1.00 31.80 ?  77   THR C OG1 1 
ATOM   2983 C CG2 . THR B 2 77  ? -28.932 -72.705 12.359  1.00 30.95 ?  77   THR C CG2 1 
ATOM   2984 N N   . VAL B 2 78  ? -29.244 -71.133 15.171  1.00 26.61 ?  78   VAL C N   1 
ATOM   2985 C CA  . VAL B 2 78  ? -30.513 -70.797 15.802  1.00 29.50 ?  78   VAL C CA  1 
ATOM   2986 C C   . VAL B 2 78  ? -31.553 -70.668 14.700  1.00 30.48 ?  78   VAL C C   1 
ATOM   2987 O O   . VAL B 2 78  ? -31.247 -70.200 13.598  1.00 55.77 ?  78   VAL C O   1 
ATOM   2988 C CB  . VAL B 2 78  ? -30.413 -69.505 16.639  1.00 31.22 ?  78   VAL C CB  1 
ATOM   2989 C CG1 . VAL B 2 78  ? -31.642 -69.346 17.508  1.00 30.36 ?  78   VAL C CG1 1 
ATOM   2990 C CG2 . VAL B 2 78  ? -29.158 -69.539 17.497  1.00 30.02 ?  78   VAL C CG2 1 
ATOM   2991 N N   . PHE B 2 79  ? -32.781 -71.116 14.993  1.00 25.55 ?  79   PHE C N   1 
ATOM   2992 C CA  . PHE B 2 79  ? -33.867 -71.143 14.027  1.00 24.53 ?  79   PHE C CA  1 
ATOM   2993 C C   . PHE B 2 79  ? -35.050 -70.339 14.537  1.00 24.06 ?  79   PHE C C   1 
ATOM   2994 O O   . PHE B 2 79  ? -35.310 -70.285 15.745  1.00 18.75 ?  79   PHE C O   1 
ATOM   2995 C CB  . PHE B 2 79  ? -34.341 -72.596 13.756  1.00 28.49 ?  79   PHE C CB  1 
ATOM   2996 C CG  . PHE B 2 79  ? -33.259 -73.505 13.246  1.00 26.22 ?  79   PHE C CG  1 
ATOM   2997 C CD1 . PHE B 2 79  ? -32.920 -73.502 11.906  1.00 23.22 ?  79   PHE C CD1 1 
ATOM   2998 C CD2 . PHE B 2 79  ? -32.572 -74.345 14.105  1.00 31.63 ?  79   PHE C CD2 1 
ATOM   2999 C CE1 . PHE B 2 79  ? -31.923 -74.356 11.419  1.00 29.74 ?  79   PHE C CE1 1 
ATOM   3000 C CE2 . PHE B 2 79  ? -31.585 -75.192 13.631  1.00 34.69 ?  79   PHE C CE2 1 
ATOM   3001 C CZ  . PHE B 2 79  ? -31.260 -75.187 12.283  1.00 32.45 ?  79   PHE C CZ  1 
ATOM   3002 N N   . LEU B 2 80  ? -35.787 -69.730 13.614  1.00 20.90 ?  80   LEU C N   1 
ATOM   3003 C CA  . LEU B 2 80  ? -37.079 -69.121 13.930  1.00 31.44 ?  80   LEU C CA  1 
ATOM   3004 C C   . LEU B 2 80  ? -38.102 -69.661 12.934  1.00 45.41 ?  80   LEU C C   1 
ATOM   3005 O O   . LEU B 2 80  ? -38.139 -69.241 11.773  1.00 53.08 ?  80   LEU C O   1 
ATOM   3006 C CB  . LEU B 2 80  ? -37.039 -67.597 13.870  1.00 24.38 ?  80   LEU C CB  1 
ATOM   3007 C CG  . LEU B 2 80  ? -38.292 -66.942 14.476  1.00 32.56 ?  80   LEU C CG  1 
ATOM   3008 C CD1 . LEU B 2 80  ? -38.408 -67.252 15.962  1.00 45.67 ?  80   LEU C CD1 1 
ATOM   3009 C CD2 . LEU B 2 80  ? -38.352 -65.442 14.221  1.00 44.04 ?  80   LEU C CD2 1 
ATOM   3010 N N   . GLN B 2 81  ? -38.924 -70.601 13.390  1.00 31.29 ?  81   GLN C N   1 
ATOM   3011 C CA  . GLN B 2 81  ? -40.042 -71.084 12.586  1.00 31.27 ?  81   GLN C CA  1 
ATOM   3012 C C   . GLN B 2 81  ? -41.183 -70.079 12.686  1.00 30.29 ?  81   GLN C C   1 
ATOM   3013 O O   . GLN B 2 81  ? -41.640 -69.767 13.790  1.00 31.10 ?  81   GLN C O   1 
ATOM   3014 C CB  . GLN B 2 81  ? -40.480 -72.462 13.074  1.00 38.50 ?  81   GLN C CB  1 
ATOM   3015 C CG  . GLN B 2 81  ? -41.721 -72.986 12.348  1.00 30.74 ?  81   GLN C CG  1 
ATOM   3016 C CD  . GLN B 2 81  ? -41.392 -73.363 10.906  1.00 30.78 ?  81   GLN C CD  1 
ATOM   3017 O OE1 . GLN B 2 81  ? -40.333 -73.944 10.625  1.00 29.05 ?  81   GLN C OE1 1 
ATOM   3018 N NE2 . GLN B 2 81  ? -42.291 -73.045 9.997   1.00 26.41 ?  81   GLN C NE2 1 
ATOM   3019 N N   . MET B 2 82  ? -41.654 -69.586 11.543  1.00 25.72 ?  82   MET C N   1 
ATOM   3020 C CA  . MET B 2 82  ? -42.576 -68.456 11.482  1.00 28.33 ?  82   MET C CA  1 
ATOM   3021 C C   . MET B 2 82  ? -43.862 -68.900 10.774  1.00 28.70 ?  82   MET C C   1 
ATOM   3022 O O   . MET B 2 82  ? -43.866 -69.049 9.553   1.00 26.76 ?  82   MET C O   1 
ATOM   3023 C CB  . MET B 2 82  ? -41.870 -67.345 10.712  1.00 29.03 ?  82   MET C CB  1 
ATOM   3024 C CG  . MET B 2 82  ? -40.774 -66.674 11.528  1.00 30.19 ?  82   MET C CG  1 
ATOM   3025 S SD  . MET B 2 82  ? -40.220 -65.201 10.626  1.00 27.24 ?  82   MET C SD  1 
ATOM   3026 C CE  . MET B 2 82  ? -41.175 -64.006 11.507  1.00 30.43 ?  82   MET C CE  1 
ATOM   3027 N N   . ASN B 2 83  ? -44.951 -69.106 11.523  1.00 31.31 ?  83   ASN C N   1 
ATOM   3028 C CA  . ASN B 2 83  ? -46.224 -69.537 10.943  1.00 29.27 ?  83   ASN C CA  1 
ATOM   3029 C C   . ASN B 2 83  ? -47.283 -68.452 11.065  1.00 33.49 ?  83   ASN C C   1 
ATOM   3030 O O   . ASN B 2 83  ? -47.187 -67.551 11.909  1.00 26.92 ?  83   ASN C O   1 
ATOM   3031 C CB  . ASN B 2 83  ? -46.748 -70.801 11.634  1.00 27.13 ?  83   ASN C CB  1 
ATOM   3032 C CG  . ASN B 2 83  ? -45.836 -71.982 11.456  1.00 29.92 ?  83   ASN C CG  1 
ATOM   3033 O OD1 . ASN B 2 83  ? -45.218 -72.152 10.403  1.00 29.74 ?  83   ASN C OD1 1 
ATOM   3034 N ND2 . ASN B 2 83  ? -45.735 -72.811 12.492  1.00 25.16 ?  83   ASN C ND2 1 
ATOM   3035 N N   . SER B 2 84  ? -48.341 -68.589 10.252  1.00 29.76 ?  84   SER C N   1 
ATOM   3036 C CA  . SER B 2 84  ? -49.490 -67.690 10.324  1.00 30.97 ?  84   SER C CA  1 
ATOM   3037 C C   . SER B 2 84  ? -49.039 -66.241 10.200  1.00 29.99 ?  84   SER C C   1 
ATOM   3038 O O   . SER B 2 84  ? -49.453 -65.360 10.963  1.00 29.04 ?  84   SER C O   1 
ATOM   3039 C CB  . SER B 2 84  ? -50.283 -67.890 11.620  1.00 28.23 ?  84   SER C CB  1 
ATOM   3040 O OG  . SER B 2 84  ? -50.762 -69.224 11.745  1.00 36.69 ?  84   SER C OG  1 
ATOM   3041 N N   . LEU B 2 85  ? -48.206 -65.996 9.201   1.00 28.54 ?  85   LEU C N   1 
ATOM   3042 C CA  . LEU B 2 85  ? -47.583 -64.690 9.072   1.00 31.22 ?  85   LEU C CA  1 
ATOM   3043 C C   . LEU B 2 85  ? -48.614 -63.633 8.673   1.00 37.10 ?  85   LEU C C   1 
ATOM   3044 O O   . LEU B 2 85  ? -49.610 -63.916 7.990   1.00 32.40 ?  85   LEU C O   1 
ATOM   3045 C CB  . LEU B 2 85  ? -46.430 -64.775 8.074   1.00 29.77 ?  85   LEU C CB  1 
ATOM   3046 C CG  . LEU B 2 85  ? -45.117 -65.323 8.657   1.00 31.99 ?  85   LEU C CG  1 
ATOM   3047 C CD1 . LEU B 2 85  ? -44.169 -65.844 7.575   1.00 22.41 ?  85   LEU C CD1 1 
ATOM   3048 C CD2 . LEU B 2 85  ? -44.411 -64.272 9.540   1.00 29.57 ?  85   LEU C CD2 1 
ATOM   3049 N N   . LYS B 2 86  ? -48.387 -62.412 9.144   1.00 33.01 ?  86   LYS C N   1 
ATOM   3050 C CA  . LYS B 2 86  ? -49.252 -61.272 8.891   1.00 35.28 ?  86   LYS C CA  1 
ATOM   3051 C C   . LYS B 2 86  ? -48.429 -60.145 8.287   1.00 39.48 ?  86   LYS C C   1 
ATOM   3052 O O   . LYS B 2 86  ? -47.204 -60.100 8.470   1.00 30.24 ?  86   LYS C O   1 
ATOM   3053 C CB  . LYS B 2 86  ? -49.905 -60.791 10.196  1.00 41.19 ?  86   LYS C CB  1 
ATOM   3054 C CG  . LYS B 2 86  ? -50.639 -61.870 10.967  1.00 40.41 ?  86   LYS C CG  1 
ATOM   3055 C CD  . LYS B 2 86  ? -51.013 -61.336 12.336  1.00 45.33 ?  86   LYS C CD  1 
ATOM   3056 C CE  . LYS B 2 86  ? -51.763 -62.353 13.177  1.00 45.69 ?  86   LYS C CE  1 
ATOM   3057 N NZ  . LYS B 2 86  ? -51.955 -61.833 14.557  1.00 49.53 ?  86   LYS C NZ  1 
ATOM   3058 N N   . PRO B 2 87  ? -49.062 -59.221 7.548   1.00 40.74 ?  87   PRO C N   1 
ATOM   3059 C CA  . PRO B 2 87  ? -48.304 -58.084 6.984   1.00 41.98 ?  87   PRO C CA  1 
ATOM   3060 C C   . PRO B 2 87  ? -47.537 -57.284 8.031   1.00 39.60 ?  87   PRO C C   1 
ATOM   3061 O O   . PRO B 2 87  ? -46.476 -56.722 7.718   1.00 30.56 ?  87   PRO C O   1 
ATOM   3062 C CB  . PRO B 2 87  ? -49.398 -57.238 6.323   1.00 45.46 ?  87   PRO C CB  1 
ATOM   3063 C CG  . PRO B 2 87  ? -50.446 -58.235 5.935   1.00 45.32 ?  87   PRO C CG  1 
ATOM   3064 C CD  . PRO B 2 87  ? -50.460 -59.245 7.066   1.00 44.10 ?  87   PRO C CD  1 
ATOM   3065 N N   . GLU B 2 88  ? -48.058 -57.214 9.263   1.00 41.92 ?  88   GLU C N   1 
ATOM   3066 C CA  . GLU B 2 88  ? -47.398 -56.517 10.362  1.00 42.95 ?  88   GLU C CA  1 
ATOM   3067 C C   . GLU B 2 88  ? -46.063 -57.151 10.740  1.00 37.78 ?  88   GLU C C   1 
ATOM   3068 O O   . GLU B 2 88  ? -45.279 -56.532 11.468  1.00 30.16 ?  88   GLU C O   1 
ATOM   3069 C CB  . GLU B 2 88  ? -48.310 -56.508 11.590  1.00 45.59 ?  88   GLU C CB  1 
ATOM   3070 C CG  . GLU B 2 88  ? -49.652 -55.865 11.360  1.00 58.65 ?  88   GLU C CG  1 
ATOM   3071 C CD  . GLU B 2 88  ? -50.741 -56.894 11.123  1.00 60.54 ?  88   GLU C CD  1 
ATOM   3072 O OE1 . GLU B 2 88  ? -50.808 -57.449 10.007  1.00 59.68 ?  88   GLU C OE1 1 
ATOM   3073 O OE2 . GLU B 2 88  ? -51.508 -57.172 12.068  1.00 66.08 -1 88   GLU C OE2 1 
ATOM   3074 N N   . ASP B 2 89  ? -45.809 -58.378 10.303  1.00 29.20 ?  89   ASP C N   1 
ATOM   3075 C CA  . ASP B 2 89  ? -44.527 -59.049 10.532  1.00 27.99 ?  89   ASP C CA  1 
ATOM   3076 C C   . ASP B 2 89  ? -43.462 -58.676 9.510   1.00 26.71 ?  89   ASP C C   1 
ATOM   3077 O O   . ASP B 2 89  ? -42.322 -59.139 9.642   1.00 20.91 ?  89   ASP C O   1 
ATOM   3078 C CB  . ASP B 2 89  ? -44.708 -60.573 10.502  1.00 27.80 ?  89   ASP C CB  1 
ATOM   3079 C CG  . ASP B 2 89  ? -45.663 -61.073 11.581  1.00 34.40 ?  89   ASP C CG  1 
ATOM   3080 O OD1 . ASP B 2 89  ? -45.553 -60.657 12.759  1.00 26.44 ?  89   ASP C OD1 1 
ATOM   3081 O OD2 . ASP B 2 89  ? -46.556 -61.878 11.231  1.00 28.87 -1 89   ASP C OD2 1 
ATOM   3082 N N   . THR B 2 90  ? -43.792 -57.884 8.485   1.00 23.89 ?  90   THR C N   1 
ATOM   3083 C CA  . THR B 2 90  ? -42.790 -57.486 7.503   1.00 23.05 ?  90   THR C CA  1 
ATOM   3084 C C   . THR B 2 90  ? -41.672 -56.704 8.183   1.00 21.44 ?  90   THR C C   1 
ATOM   3085 O O   . THR B 2 90  ? -41.941 -55.752 8.925   1.00 22.96 ?  90   THR C O   1 
ATOM   3086 C CB  . THR B 2 90  ? -43.442 -56.634 6.409   1.00 25.81 ?  90   THR C CB  1 
ATOM   3087 O OG1 . THR B 2 90  ? -44.388 -57.441 5.704   1.00 27.17 ?  90   THR C OG1 1 
ATOM   3088 C CG2 . THR B 2 90  ? -42.397 -56.111 5.420   1.00 23.36 ?  90   THR C CG2 1 
ATOM   3089 N N   . ALA B 2 91  ? -40.419 -57.104 7.919   1.00 21.94 ?  91   ALA C N   1 
ATOM   3090 C CA  . ALA B 2 91  ? -39.269 -56.470 8.581   1.00 20.57 ?  91   ALA C CA  1 
ATOM   3091 C C   . ALA B 2 91  ? -37.988 -57.178 8.192   1.00 19.53 ?  91   ALA C C   1 
ATOM   3092 O O   . ALA B 2 91  ? -38.038 -58.266 7.611   1.00 19.27 ?  91   ALA C O   1 
ATOM   3093 C CB  . ALA B 2 91  ? -39.430 -56.514 10.110  1.00 17.13 ?  91   ALA C CB  1 
ATOM   3094 N N   . VAL B 2 92  ? -36.824 -56.569 8.468   1.00 17.73 ?  92   VAL C N   1 
ATOM   3095 C CA  . VAL B 2 92  ? -35.574 -57.317 8.450   1.00 17.31 ?  92   VAL C CA  1 
ATOM   3096 C C   . VAL B 2 92  ? -35.408 -57.994 9.810   1.00 13.75 ?  92   VAL C C   1 
ATOM   3097 O O   . VAL B 2 92  ? -35.548 -57.353 10.856  1.00 16.52 ?  92   VAL C O   1 
ATOM   3098 C CB  . VAL B 2 92  ? -34.369 -56.397 8.156   1.00 19.10 ?  92   VAL C CB  1 
ATOM   3099 C CG1 . VAL B 2 92  ? -33.100 -57.218 8.122   1.00 18.79 ?  92   VAL C CG1 1 
ATOM   3100 C CG2 . VAL B 2 92  ? -34.560 -55.603 6.859   1.00 22.78 ?  92   VAL C CG2 1 
ATOM   3101 N N   . TYR B 2 93  ? -35.138 -59.300 9.798   1.00 16.24 ?  93   TYR C N   1 
ATOM   3102 C CA  . TYR B 2 93  ? -35.000 -60.081 11.020  1.00 17.68 ?  93   TYR C CA  1 
ATOM   3103 C C   . TYR B 2 93  ? -33.528 -60.397 11.261  1.00 18.00 ?  93   TYR C C   1 
ATOM   3104 O O   . TYR B 2 93  ? -32.782 -60.691 10.320  1.00 15.04 ?  93   TYR C O   1 
ATOM   3105 C CB  . TYR B 2 93  ? -35.812 -61.391 10.919  1.00 18.37 ?  93   TYR C CB  1 
ATOM   3106 C CG  . TYR B 2 93  ? -37.301 -61.185 11.120  1.00 18.51 ?  93   TYR C CG  1 
ATOM   3107 C CD1 . TYR B 2 93  ? -38.071 -60.547 10.150  1.00 19.46 ?  93   TYR C CD1 1 
ATOM   3108 C CD2 . TYR B 2 93  ? -37.941 -61.641 12.276  1.00 21.01 ?  93   TYR C CD2 1 
ATOM   3109 C CE1 . TYR B 2 93  ? -39.435 -60.348 10.341  1.00 22.19 ?  93   TYR C CE1 1 
ATOM   3110 C CE2 . TYR B 2 93  ? -39.303 -61.454 12.464  1.00 31.04 ?  93   TYR C CE2 1 
ATOM   3111 C CZ  . TYR B 2 93  ? -40.044 -60.812 11.493  1.00 36.53 ?  93   TYR C CZ  1 
ATOM   3112 O OH  . TYR B 2 93  ? -41.396 -60.618 11.672  1.00 54.59 ?  93   TYR C OH  1 
ATOM   3113 N N   . TYR B 2 94  ? -33.123 -60.364 12.534  1.00 15.71 ?  94   TYR C N   1 
ATOM   3114 C CA  . TYR B 2 94  ? -31.727 -60.511 12.925  1.00 15.51 ?  94   TYR C CA  1 
ATOM   3115 C C   . TYR B 2 94  ? -31.628 -61.440 14.113  1.00 15.07 ?  94   TYR C C   1 
ATOM   3116 O O   . TYR B 2 94  ? -32.474 -61.407 15.004  1.00 18.01 ?  94   TYR C O   1 
ATOM   3117 C CB  . TYR B 2 94  ? -31.094 -59.191 13.397  1.00 27.29 ?  94   TYR C CB  1 
ATOM   3118 C CG  . TYR B 2 94  ? -31.113 -58.041 12.429  1.00 16.10 ?  94   TYR C CG  1 
ATOM   3119 C CD1 . TYR B 2 94  ? -32.210 -57.170 12.360  1.00 16.37 ?  94   TYR C CD1 1 
ATOM   3120 C CD2 . TYR B 2 94  ? -30.019 -57.793 11.620  1.00 16.45 ?  94   TYR C CD2 1 
ATOM   3121 C CE1 . TYR B 2 94  ? -32.216 -56.079 11.485  1.00 17.34 ?  94   TYR C CE1 1 
ATOM   3122 C CE2 . TYR B 2 94  ? -30.027 -56.698 10.733  1.00 18.91 ?  94   TYR C CE2 1 
ATOM   3123 C CZ  . TYR B 2 94  ? -31.116 -55.841 10.704  1.00 19.84 ?  94   TYR C CZ  1 
ATOM   3124 O OH  . TYR B 2 94  ? -31.114 -54.747 9.832   1.00 21.87 ?  94   TYR C OH  1 
ATOM   3125 N N   . CYS B 2 95  ? -30.535 -62.191 14.166  1.00 13.38 ?  95   CYS C N   1 
ATOM   3126 C CA  . CYS B 2 95  ? -30.241 -62.962 15.363  1.00 16.58 ?  95   CYS C CA  1 
ATOM   3127 C C   . CYS B 2 95  ? -29.037 -62.367 16.107  1.00 17.43 ?  95   CYS C C   1 
ATOM   3128 O O   . CYS B 2 95  ? -28.250 -61.624 15.529  1.00 19.14 ?  95   CYS C O   1 
ATOM   3129 C CB  . CYS B 2 95  ? -30.054 -64.422 14.929  1.00 21.95 ?  95   CYS C CB  1 
ATOM   3130 S SG  . CYS B 2 95  ? -28.571 -65.191 15.472  1.00 37.17 ?  95   CYS C SG  1 
ATOM   3131 N N   . ASN B 2 96  ? -28.933 -62.615 17.420  1.00 15.06 ?  96   ASN C N   1 
ATOM   3132 C CA  . ASN B 2 96  ? -27.771 -62.116 18.171  1.00 15.92 ?  96   ASN C CA  1 
ATOM   3133 C C   . ASN B 2 96  ? -27.572 -62.917 19.462  1.00 16.88 ?  96   ASN C C   1 
ATOM   3134 O O   . ASN B 2 96  ? -28.500 -63.556 19.961  1.00 16.12 ?  96   ASN C O   1 
ATOM   3135 C CB  . ASN B 2 96  ? -27.982 -60.618 18.478  1.00 14.17 ?  96   ASN C CB  1 
ATOM   3136 C CG  . ASN B 2 96  ? -26.686 -59.809 18.493  1.00 15.29 ?  96   ASN C CG  1 
ATOM   3137 O OD1 . ASN B 2 96  ? -25.714 -60.156 19.180  1.00 14.65 ?  96   ASN C OD1 1 
ATOM   3138 N ND2 . ASN B 2 96  ? -26.684 -58.687 17.756  1.00 15.20 ?  96   ASN C ND2 1 
ATOM   3139 N N   . ARG B 2 97  ? -26.348 -62.853 20.015  1.00 14.45 ?  97   ARG C N   1 
ATOM   3140 C CA  . ARG B 2 97  ? -26.149 -63.219 21.416  1.00 16.52 ?  97   ARG C CA  1 
ATOM   3141 C C   . ARG B 2 97  ? -26.965 -62.301 22.310  1.00 16.55 ?  97   ARG C C   1 
ATOM   3142 O O   . ARG B 2 97  ? -27.024 -61.083 22.092  1.00 15.31 ?  97   ARG C O   1 
ATOM   3143 C CB  . ARG B 2 97  ? -24.674 -63.120 21.806  1.00 16.15 ?  97   ARG C CB  1 
ATOM   3144 C CG  . ARG B 2 97  ? -23.752 -63.942 20.889  1.00 16.41 ?  97   ARG C CG  1 
ATOM   3145 C CD  . ARG B 2 97  ? -22.286 -63.749 21.311  1.00 18.15 ?  97   ARG C CD  1 
ATOM   3146 N NE  . ARG B 2 97  ? -22.027 -64.355 22.621  1.00 20.15 ?  97   ARG C NE  1 
ATOM   3147 C CZ  . ARG B 2 97  ? -21.506 -63.721 23.669  1.00 20.66 ?  97   ARG C CZ  1 
ATOM   3148 N NH1 . ARG B 2 97  ? -21.209 -62.417 23.628  1.00 17.65 ?  97   ARG C NH1 1 
ATOM   3149 N NH2 . ARG B 2 97  ? -21.245 -64.412 24.779  1.00 19.91 ?  97   ARG C NH2 1 
ATOM   3150 N N   . ALA B 2 98  ? -27.558 -62.866 23.356  1.00 15.31 ?  98   ALA C N   1 
ATOM   3151 C CA  . ALA B 2 98  ? -28.496 -62.106 24.181  1.00 16.11 ?  98   ALA C CA  1 
ATOM   3152 C C   . ALA B 2 98  ? -28.222 -62.372 25.660  1.00 17.48 ?  98   ALA C C   1 
ATOM   3153 O O   . ALA B 2 98  ? -27.698 -63.429 26.040  1.00 17.25 ?  98   ALA C O   1 
ATOM   3154 C CB  . ALA B 2 98  ? -29.971 -62.462 23.851  1.00 14.85 ?  98   ALA C CB  1 
ATOM   3155 N N   . LYS B 2 99  ? -28.654 -61.429 26.506  1.00 16.30 ?  99   LYS C N   1 
ATOM   3156 C CA  . LYS B 2 99  ? -28.463 -61.560 27.945  1.00 15.32 ?  99   LYS C CA  1 
ATOM   3157 C C   . LYS B 2 99  ? -29.818 -61.781 28.604  1.00 16.28 ?  99   LYS C C   1 
ATOM   3158 O O   . LYS B 2 99  ? -30.607 -60.835 28.740  1.00 17.03 ?  99   LYS C O   1 
ATOM   3159 C CB  . LYS B 2 99  ? -27.775 -60.311 28.516  1.00 16.86 ?  99   LYS C CB  1 
ATOM   3160 C CG  . LYS B 2 99  ? -27.574 -60.359 30.001  1.00 18.56 ?  99   LYS C CG  1 
ATOM   3161 C CD  . LYS B 2 99  ? -26.520 -61.401 30.367  1.00 21.18 ?  99   LYS C CD  1 
ATOM   3162 C CE  . LYS B 2 99  ? -26.316 -61.470 31.893  1.00 25.35 ?  99   LYS C CE  1 
ATOM   3163 N NZ  . LYS B 2 99  ? -25.302 -62.527 32.299  1.00 29.21 ?  99   LYS C NZ  1 
ATOM   3164 N N   . PRO B 2 100 ? -30.144 -63.004 29.033  1.00 17.88 ?  100  PRO C N   1 
ATOM   3165 C CA  . PRO B 2 100 ? -31.374 -63.216 29.822  1.00 18.72 ?  100  PRO C CA  1 
ATOM   3166 C C   . PRO B 2 100 ? -31.269 -62.495 31.157  1.00 19.24 ?  100  PRO C C   1 
ATOM   3167 O O   . PRO B 2 100 ? -30.148 -62.200 31.612  1.00 19.12 ?  100  PRO C O   1 
ATOM   3168 C CB  . PRO B 2 100 ? -31.402 -64.751 30.021  1.00 20.74 ?  100  PRO C CB  1 
ATOM   3169 C CG  . PRO B 2 100 ? -30.461 -65.310 28.975  1.00 20.14 ?  100  PRO C CG  1 
ATOM   3170 C CD  . PRO B 2 100 ? -29.364 -64.251 28.885  1.00 19.39 ?  100  PRO C CD  1 
ATOM   3171 N N   . PRO B 2 101 ? -32.407 -62.174 31.817  1.00 17.64 ?  101  PRO C N   1 
ATOM   3172 C CA  . PRO B 2 101 ? -33.778 -62.522 31.468  1.00 19.10 ?  101  PRO C CA  1 
ATOM   3173 C C   . PRO B 2 101 ? -34.511 -61.596 30.469  1.00 18.95 ?  101  PRO C C   1 
ATOM   3174 O O   . PRO B 2 101 ? -35.596 -61.963 29.989  1.00 19.23 ?  101  PRO C O   1 
ATOM   3175 C CB  . PRO B 2 101 ? -34.471 -62.464 32.825  1.00 20.92 ?  101  PRO C CB  1 
ATOM   3176 C CG  . PRO B 2 101 ? -33.786 -61.343 33.522  1.00 18.53 ?  101  PRO C CG  1 
ATOM   3177 C CD  . PRO B 2 101 ? -32.356 -61.474 33.122  1.00 20.00 ?  101  PRO C CD  1 
ATOM   3178 N N   . THR B 2 102 ? -33.957 -60.413 30.180  1.00 17.01 ?  102  THR C N   1 
ATOM   3179 C CA  . THR B 2 102 ? -34.658 -59.461 29.309  1.00 16.94 ?  102  THR C CA  1 
ATOM   3180 C C   . THR B 2 102 ? -34.238 -59.546 27.845  1.00 16.53 ?  102  THR C C   1 
ATOM   3181 O O   . THR B 2 102 ? -34.911 -58.937 26.990  1.00 15.96 ?  102  THR C O   1 
ATOM   3182 C CB  . THR B 2 102 ? -34.465 -57.998 29.777  1.00 17.59 ?  102  THR C CB  1 
ATOM   3183 O OG1 . THR B 2 102 ? -33.154 -57.534 29.384  1.00 17.81 ?  102  THR C OG1 1 
ATOM   3184 C CG2 . THR B 2 102 ? -34.615 -57.861 31.255  1.00 17.03 ?  102  THR C CG2 1 
ATOM   3185 N N   . TYR B 2 103 ? -33.139 -60.235 27.536  1.00 15.23 ?  103  TYR C N   1 
ATOM   3186 C CA  . TYR B 2 103 ? -32.732 -60.517 26.159  1.00 17.20 ?  103  TYR C CA  1 
ATOM   3187 C C   . TYR B 2 103 ? -32.317 -59.249 25.404  1.00 15.63 ?  103  TYR C C   1 
ATOM   3188 O O   . TYR B 2 103 ? -32.569 -59.110 24.202  1.00 16.13 ?  103  TYR C O   1 
ATOM   3189 C CB  . TYR B 2 103 ? -33.823 -61.281 25.404  1.00 16.93 ?  103  TYR C CB  1 
ATOM   3190 C CG  . TYR B 2 103 ? -33.850 -62.711 25.924  1.00 18.12 ?  103  TYR C CG  1 
ATOM   3191 C CD1 . TYR B 2 103 ? -34.603 -63.037 27.051  1.00 18.36 ?  103  TYR C CD1 1 
ATOM   3192 C CD2 . TYR B 2 103 ? -33.065 -63.687 25.332  1.00 18.97 ?  103  TYR C CD2 1 
ATOM   3193 C CE1 . TYR B 2 103 ? -34.596 -64.351 27.547  1.00 20.63 ?  103  TYR C CE1 1 
ATOM   3194 C CE2 . TYR B 2 103 ? -33.047 -64.989 25.817  1.00 21.00 ?  103  TYR C CE2 1 
ATOM   3195 C CZ  . TYR B 2 103 ? -33.819 -65.311 26.910  1.00 24.35 ?  103  TYR C CZ  1 
ATOM   3196 O OH  . TYR B 2 103 ? -33.776 -66.623 27.373  1.00 25.96 ?  103  TYR C OH  1 
ATOM   3197 N N   . TYR B 2 104 ? -31.562 -58.379 26.068  1.00 13.95 ?  104  TYR C N   1 
ATOM   3198 C CA  . TYR B 2 104 ? -30.880 -57.378 25.243  1.00 14.73 ?  104  TYR C CA  1 
ATOM   3199 C C   . TYR B 2 104 ? -29.764 -58.041 24.462  1.00 14.36 ?  104  TYR C C   1 
ATOM   3200 O O   . TYR B 2 104 ? -29.141 -59.004 24.930  1.00 15.08 ?  104  TYR C O   1 
ATOM   3201 C CB  . TYR B 2 104 ? -30.378 -56.191 26.088  1.00 13.37 ?  104  TYR C CB  1 
ATOM   3202 C CG  . TYR B 2 104 ? -29.350 -56.431 27.196  1.00 14.06 ?  104  TYR C CG  1 
ATOM   3203 C CD1 . TYR B 2 104 ? -27.986 -56.551 26.905  1.00 15.16 ?  104  TYR C CD1 1 
ATOM   3204 C CD2 . TYR B 2 104 ? -29.744 -56.463 28.547  1.00 13.51 ?  104  TYR C CD2 1 
ATOM   3205 C CE1 . TYR B 2 104 ? -27.044 -56.706 27.928  1.00 14.64 ?  104  TYR C CE1 1 
ATOM   3206 C CE2 . TYR B 2 104 ? -28.820 -56.617 29.573  1.00 15.40 ?  104  TYR C CE2 1 
ATOM   3207 C CZ  . TYR B 2 104 ? -27.459 -56.740 29.249  1.00 17.56 ?  104  TYR C CZ  1 
ATOM   3208 O OH  . TYR B 2 104 ? -26.518 -56.899 30.264  1.00 19.32 ?  104  TYR C OH  1 
ATOM   3209 N N   . SER B 2 105 ? -29.513 -57.534 23.238  1.00 13.86 ?  105  SER C N   1 
ATOM   3210 C CA  . SER B 2 105 ? -28.478 -58.128 22.402  1.00 13.36 ?  105  SER C CA  1 
ATOM   3211 C C   . SER B 2 105 ? -27.088 -57.607 22.794  1.00 13.56 ?  105  SER C C   1 
ATOM   3212 O O   . SER B 2 105 ? -26.941 -56.573 23.456  1.00 14.27 ?  105  SER C O   1 
ATOM   3213 C CB  . SER B 2 105 ? -28.747 -57.848 20.925  1.00 15.73 ?  105  SER C CB  1 
ATOM   3214 O OG  . SER B 2 105 ? -28.736 -56.419 20.715  1.00 15.21 ?  105  SER C OG  1 
ATOM   3215 N N   . LEU B 2 106 ? -26.063 -58.366 22.404  1.00 12.40 ?  106  LEU C N   1 
ATOM   3216 C CA  . LEU B 2 106 ? -24.696 -58.132 22.885  1.00 13.86 ?  106  LEU C CA  1 
ATOM   3217 C C   . LEU B 2 106 ? -23.692 -57.674 21.820  1.00 13.49 ?  106  LEU C C   1 
ATOM   3218 O O   . LEU B 2 106 ? -22.706 -57.013 22.179  1.00 14.98 ?  106  LEU C O   1 
ATOM   3219 C CB  . LEU B 2 106 ? -24.138 -59.403 23.554  1.00 14.46 ?  106  LEU C CB  1 
ATOM   3220 C CG  . LEU B 2 106 ? -24.880 -59.779 24.828  1.00 14.91 ?  106  LEU C CG  1 
ATOM   3221 C CD1 . LEU B 2 106 ? -24.335 -61.116 25.383  1.00 16.71 ?  106  LEU C CD1 1 
ATOM   3222 C CD2 . LEU B 2 106 ? -24.778 -58.659 25.879  1.00 15.12 ?  106  LEU C CD2 1 
ATOM   3223 N N   . GLU B 2 107 ? -23.867 -58.037 20.551  1.00 13.04 ?  107  GLU C N   1 
ATOM   3224 C CA  . GLU B 2 107 ? -22.847 -57.896 19.519  1.00 14.41 ?  107  GLU C CA  1 
ATOM   3225 C C   . GLU B 2 107 ? -23.282 -56.965 18.373  1.00 13.97 ?  107  GLU C C   1 
ATOM   3226 O O   . GLU B 2 107 ? -24.483 -56.835 18.088  1.00 15.74 ?  107  GLU C O   1 
ATOM   3227 C CB  . GLU B 2 107 ? -22.515 -59.262 18.899  1.00 14.03 ?  107  GLU C CB  1 
ATOM   3228 C CG  . GLU B 2 107 ? -22.089 -60.351 19.875  1.00 13.82 ?  107  GLU C CG  1 
ATOM   3229 C CD  . GLU B 2 107 ? -20.741 -60.036 20.484  1.00 15.80 ?  107  GLU C CD  1 
ATOM   3230 O OE1 . GLU B 2 107 ? -19.953 -59.269 19.863  1.00 16.12 ?  107  GLU C OE1 1 
ATOM   3231 O OE2 . GLU B 2 107 ? -20.438 -60.545 21.591  1.00 14.85 -1 107  GLU C OE2 1 
ATOM   3232 N N   . PRO B 2 108 ? -22.326 -56.394 17.622  1.00 14.54 ?  108  PRO C N   1 
ATOM   3233 C CA  . PRO B 2 108 ? -22.671 -55.805 16.313  1.00 14.21 ?  108  PRO C CA  1 
ATOM   3234 C C   . PRO B 2 108 ? -23.484 -56.781 15.468  1.00 15.76 ?  108  PRO C C   1 
ATOM   3235 O O   . PRO B 2 108 ? -23.278 -58.006 15.516  1.00 16.83 ?  108  PRO C O   1 
ATOM   3236 C CB  . PRO B 2 108 ? -21.304 -55.539 15.666  1.00 13.84 ?  108  PRO C CB  1 
ATOM   3237 C CG  . PRO B 2 108 ? -20.378 -55.352 16.826  1.00 15.48 ?  108  PRO C CG  1 
ATOM   3238 C CD  . PRO B 2 108 ? -20.880 -56.316 17.896  1.00 14.44 ?  108  PRO C CD  1 
ATOM   3239 N N   . TRP B 2 109 ? -24.367 -56.228 14.657  1.00 15.25 ?  109  TRP C N   1 
ATOM   3240 C CA  . TRP B 2 109 ? -25.351 -57.037 13.923  1.00 15.24 ?  109  TRP C CA  1 
ATOM   3241 C C   . TRP B 2 109 ? -24.778 -57.694 12.667  1.00 17.52 ?  109  TRP C C   1 
ATOM   3242 O O   . TRP B 2 109 ? -23.882 -57.152 12.007  1.00 16.88 ?  109  TRP C O   1 
ATOM   3243 C CB  . TRP B 2 109 ? -26.548 -56.172 13.511  1.00 14.77 ?  109  TRP C CB  1 
ATOM   3244 C CG  . TRP B 2 109 ? -27.264 -55.611 14.731  1.00 16.96 ?  109  TRP C CG  1 
ATOM   3245 C CD1 . TRP B 2 109 ? -27.038 -54.393 15.330  1.00 16.47 ?  109  TRP C CD1 1 
ATOM   3246 C CD2 . TRP B 2 109 ? -28.260 -56.276 15.537  1.00 15.74 ?  109  TRP C CD2 1 
ATOM   3247 N NE1 . TRP B 2 109 ? -27.832 -54.262 16.453  1.00 18.09 ?  109  TRP C NE1 1 
ATOM   3248 C CE2 . TRP B 2 109 ? -28.606 -55.391 16.589  1.00 17.73 ?  109  TRP C CE2 1 
ATOM   3249 C CE3 . TRP B 2 109 ? -28.887 -57.534 15.469  1.00 15.72 ?  109  TRP C CE3 1 
ATOM   3250 C CZ2 . TRP B 2 109 ? -29.554 -55.706 17.567  1.00 16.50 ?  109  TRP C CZ2 1 
ATOM   3251 C CZ3 . TRP B 2 109 ? -29.871 -57.842 16.419  1.00 15.42 ?  109  TRP C CZ3 1 
ATOM   3252 C CH2 . TRP B 2 109 ? -30.180 -56.950 17.461  1.00 15.43 ?  109  TRP C CH2 1 
ATOM   3253 N N   . GLY B 2 110 ? -25.345 -58.856 12.306  1.00 15.12 ?  110  GLY C N   1 
ATOM   3254 C CA  . GLY B 2 110 ? -25.208 -59.396 10.966  1.00 17.52 ?  110  GLY C CA  1 
ATOM   3255 C C   . GLY B 2 110 ? -26.058 -58.627 9.944   1.00 16.46 ?  110  GLY C C   1 
ATOM   3256 O O   . GLY B 2 110 ? -26.693 -57.618 10.243  1.00 16.47 ?  110  GLY C O   1 
ATOM   3257 N N   . LYS B 2 111 ? -26.064 -59.131 8.705   1.00 17.21 ?  111  LYS C N   1 
ATOM   3258 C CA  . LYS B 2 111 ? -26.794 -58.452 7.638   1.00 19.00 ?  111  LYS C CA  1 
ATOM   3259 C C   . LYS B 2 111 ? -28.309 -58.604 7.754   1.00 19.54 ?  111  LYS C C   1 
ATOM   3260 O O   . LYS B 2 111 ? -29.050 -57.802 7.171   1.00 19.90 ?  111  LYS C O   1 
ATOM   3261 C CB  . LYS B 2 111 ? -26.324 -58.966 6.274   1.00 22.64 ?  111  LYS C CB  1 
ATOM   3262 C CG  . LYS B 2 111 ? -24.858 -58.659 6.006   1.00 26.87 ?  111  LYS C CG  1 
ATOM   3263 C CD  . LYS B 2 111 ? -24.154 -59.717 5.171   1.00 36.80 ?  111  LYS C CD  1 
ATOM   3264 C CE  . LYS B 2 111 ? -22.729 -59.260 4.765   1.00 42.71 ?  111  LYS C CE  1 
ATOM   3265 N NZ  . LYS B 2 111 ? -22.062 -60.225 3.816   1.00 51.01 ?  111  LYS C NZ  1 
ATOM   3266 N N   . GLY B 2 112 ? -28.796 -59.625 8.482   1.00 19.93 ?  112  GLY C N   1 
ATOM   3267 C CA  . GLY B 2 112 ? -30.234 -59.805 8.632   1.00 16.93 ?  112  GLY C CA  1 
ATOM   3268 C C   . GLY B 2 112 ? -30.822 -60.499 7.412   1.00 22.10 ?  112  GLY C C   1 
ATOM   3269 O O   . GLY B 2 112 ? -30.138 -60.774 6.423   1.00 20.69 ?  112  GLY C O   1 
ATOM   3270 N N   . THR B 2 113 ? -32.120 -60.785 7.481   1.00 19.50 ?  113  THR C N   1 
ATOM   3271 C CA  . THR B 2 113 ? -32.819 -61.433 6.365   1.00 19.93 ?  113  THR C CA  1 
ATOM   3272 C C   . THR B 2 113 ? -34.216 -60.827 6.246   1.00 18.94 ?  113  THR C C   1 
ATOM   3273 O O   . THR B 2 113 ? -34.926 -60.667 7.241   1.00 18.32 ?  113  THR C O   1 
ATOM   3274 C CB  . THR B 2 113 ? -32.834 -62.980 6.553   1.00 22.27 ?  113  THR C CB  1 
ATOM   3275 O OG1 . THR B 2 113 ? -33.301 -63.632 5.358   1.00 25.28 ?  113  THR C OG1 1 
ATOM   3276 C CG2 . THR B 2 113 ? -33.691 -63.403 7.739   1.00 20.58 ?  113  THR C CG2 1 
ATOM   3277 N N   . GLN B 2 114 ? -34.591 -60.428 5.020   1.00 19.80 ?  114  GLN C N   1 
ATOM   3278 C CA  . GLN B 2 114 ? -35.838 -59.716 4.776   1.00 19.76 ?  114  GLN C CA  1 
ATOM   3279 C C   . GLN B 2 114 ? -37.030 -60.668 4.788   1.00 18.96 ?  114  GLN C C   1 
ATOM   3280 O O   . GLN B 2 114 ? -37.035 -61.676 4.080   1.00 23.60 ?  114  GLN C O   1 
ATOM   3281 C CB  . GLN B 2 114 ? -35.782 -59.011 3.419   1.00 21.48 ?  114  GLN C CB  1 
ATOM   3282 C CG  . GLN B 2 114 ? -37.053 -58.257 3.064   1.00 21.26 ?  114  GLN C CG  1 
ATOM   3283 C CD  . GLN B 2 114 ? -37.252 -57.041 3.924   1.00 22.55 ?  114  GLN C CD  1 
ATOM   3284 O OE1 . GLN B 2 114 ? -36.375 -56.160 3.968   1.00 24.59 ?  114  GLN C OE1 1 
ATOM   3285 N NE2 . GLN B 2 114 ? -38.402 -56.955 4.596   1.00 22.75 ?  114  GLN C NE2 1 
ATOM   3286 N N   . VAL B 2 115 ? -38.038 -60.336 5.580   1.00 20.69 ?  115  VAL C N   1 
ATOM   3287 C CA  . VAL B 2 115 ? -39.330 -61.011 5.571   1.00 22.54 ?  115  VAL C CA  1 
ATOM   3288 C C   . VAL B 2 115 ? -40.366 -60.035 5.031   1.00 23.34 ?  115  VAL C C   1 
ATOM   3289 O O   . VAL B 2 115 ? -40.512 -58.928 5.562   1.00 23.26 ?  115  VAL C O   1 
ATOM   3290 C CB  . VAL B 2 115 ? -39.692 -61.499 6.985   1.00 21.35 ?  115  VAL C CB  1 
ATOM   3291 C CG1 . VAL B 2 115 ? -41.180 -61.967 7.076   1.00 23.88 ?  115  VAL C CG1 1 
ATOM   3292 C CG2 . VAL B 2 115 ? -38.731 -62.614 7.411   1.00 21.15 ?  115  VAL C CG2 1 
ATOM   3293 N N   . THR B 2 116 ? -41.113 -60.443 3.990   1.00 24.68 ?  116  THR C N   1 
ATOM   3294 C CA  . THR B 2 116 ? -42.167 -59.594 3.432   1.00 25.31 ?  116  THR C CA  1 
ATOM   3295 C C   . THR B 2 116 ? -43.438 -60.419 3.291   1.00 25.07 ?  116  THR C C   1 
ATOM   3296 O O   . THR B 2 116 ? -43.435 -61.470 2.637   1.00 27.13 ?  116  THR C O   1 
ATOM   3297 C CB  . THR B 2 116 ? -41.762 -58.991 2.079   1.00 30.94 ?  116  THR C CB  1 
ATOM   3298 O OG1 . THR B 2 116 ? -40.552 -58.236 2.227   1.00 28.84 ?  116  THR C OG1 1 
ATOM   3299 C CG2 . THR B 2 116 ? -42.847 -58.073 1.555   1.00 31.76 ?  116  THR C CG2 1 
ATOM   3300 N N   . VAL B 2 117 ? -44.501 -59.955 3.930   1.00 29.36 ?  117  VAL C N   1 
ATOM   3301 C CA  . VAL B 2 117 ? -45.777 -60.664 3.973   1.00 32.91 ?  117  VAL C CA  1 
ATOM   3302 C C   . VAL B 2 117 ? -46.794 -59.808 3.231   1.00 36.42 ?  117  VAL C C   1 
ATOM   3303 O O   . VAL B 2 117 ? -47.170 -58.724 3.702   1.00 35.21 ?  117  VAL C O   1 
ATOM   3304 C CB  . VAL B 2 117 ? -46.229 -60.936 5.414   1.00 35.90 ?  117  VAL C CB  1 
ATOM   3305 C CG1 . VAL B 2 117 ? -47.494 -61.810 5.427   1.00 33.79 ?  117  VAL C CG1 1 
ATOM   3306 C CG2 . VAL B 2 117 ? -45.090 -61.596 6.221   1.00 30.19 ?  117  VAL C CG2 1 
ATOM   3307 N N   . SER B 2 118 ? -47.259 -60.305 2.086   1.00 38.82 ?  118  SER C N   1 
ATOM   3308 C CA  . SER B 2 118 ? -48.224 -59.564 1.289   1.00 45.21 ?  118  SER C CA  1 
ATOM   3309 C C   . SER B 2 118 ? -49.627 -59.776 1.836   1.00 50.95 ?  118  SER C C   1 
ATOM   3310 O O   . SER B 2 118 ? -49.964 -60.859 2.328   1.00 49.18 ?  118  SER C O   1 
ATOM   3311 C CB  . SER B 2 118 ? -48.169 -60.003 -0.171  1.00 46.24 ?  118  SER C CB  1 
ATOM   3312 O OG  . SER B 2 118 ? -48.191 -61.415 -0.253  1.00 46.54 ?  118  SER C OG  1 
ATOM   3313 N N   . SER B 2 119 ? -50.442 -58.731 1.754   1.00 55.33 ?  119  SER C N   1 
ATOM   3314 C CA  . SER B 2 119 ? -51.845 -58.810 2.134   1.00 62.37 ?  119  SER C CA  1 
ATOM   3315 C C   . SER B 2 119 ? -52.667 -59.260 0.931   1.00 71.49 ?  119  SER C C   1 
ATOM   3316 O O   . SER B 2 119 ? -52.601 -58.641 -0.137  1.00 70.54 ?  119  SER C O   1 
ATOM   3317 C CB  . SER B 2 119 ? -52.338 -57.455 2.644   1.00 62.45 ?  119  SER C CB  1 
ATOM   3318 O OG  . SER B 2 119 ? -53.710 -57.509 2.997   1.00 69.70 ?  119  SER C OG  1 
ATOM   3319 N N   . HIS B 2 120 ? -53.438 -60.353 1.102   1.00 80.88 ?  120  HIS C N   1 
ATOM   3320 C CA  . HIS B 2 120 ? -54.347 -60.800 0.033   1.00 87.20 ?  120  HIS C CA  1 
ATOM   3321 C C   . HIS B 2 120 ? -55.487 -59.774 -0.267  1.00 90.10 ?  120  HIS C C   1 
ATOM   3322 O O   . HIS B 2 120 ? -56.360 -60.061 -1.110  1.00 91.30 ?  120  HIS C O   1 
ATOM   3323 C CB  . HIS B 2 120 ? -54.926 -62.188 0.355   1.00 90.42 ?  120  HIS C CB  1 
ATOM   3324 C CG  . HIS B 2 120 ? -55.414 -62.355 1.765   1.00 94.21 ?  120  HIS C CG  1 
ATOM   3325 N ND1 . HIS B 2 120 ? -56.454 -61.619 2.293   1.00 96.70 ?  120  HIS C ND1 1 
ATOM   3326 C CD2 . HIS B 2 120 ? -55.028 -63.212 2.742   1.00 87.26 ?  120  HIS C CD2 1 
ATOM   3327 C CE1 . HIS B 2 120 ? -56.670 -61.996 3.542   1.00 98.54 ?  120  HIS C CE1 1 
ATOM   3328 N NE2 . HIS B 2 120 ? -55.819 -62.962 3.838   1.00 94.52 ?  120  HIS C NE2 1 
ATOM   3329 N N   . HIS B 2 121 ? -55.415 -58.628 0.414   1.00 89.35 ?  121  HIS C N   1 
ATOM   3330 C CA  . HIS B 2 121 ? -56.316 -57.487 0.233   1.00 83.38 ?  121  HIS C CA  1 
ATOM   3331 C C   . HIS B 2 121 ? -56.758 -57.313 -1.224  1.00 87.54 ?  121  HIS C C   1 
ATOM   3332 O O   . HIS B 2 121 ? -57.956 -57.238 -1.521  1.00 87.84 ?  121  HIS C O   1 
ATOM   3333 C CB  . HIS B 2 121 ? -55.626 -56.206 0.741   1.00 72.69 ?  121  HIS C CB  1 
ATOM   3334 C CG  . HIS B 2 121 ? -56.484 -54.976 0.679   1.00 70.48 ?  121  HIS C CG  1 
ATOM   3335 N ND1 . HIS B 2 121 ? -57.859 -55.025 0.547   1.00 65.46 ?  121  HIS C ND1 1 
ATOM   3336 C CD2 . HIS B 2 121 ? -56.158 -53.661 0.731   1.00 58.98 ?  121  HIS C CD2 1 
ATOM   3337 C CE1 . HIS B 2 121 ? -58.342 -53.794 0.521   1.00 50.35 ?  121  HIS C CE1 1 
ATOM   3338 N NE2 . HIS B 2 121 ? -57.331 -52.948 0.631   1.00 51.86 ?  121  HIS C NE2 1 
ATOM   3339 N N   . THR C 1 1   ? -5.916  -10.110 49.826  1.00 46.12 ?  224  THR B N   1 
ATOM   3340 C CA  . THR C 1 1   ? -5.204  -10.845 50.869  1.00 49.46 ?  224  THR B CA  1 
ATOM   3341 C C   . THR C 1 1   ? -5.025  -12.333 50.511  1.00 39.44 ?  224  THR B C   1 
ATOM   3342 O O   . THR C 1 1   ? -3.914  -12.861 50.636  1.00 41.22 ?  224  THR B O   1 
ATOM   3343 C CB  . THR C 1 1   ? -5.916  -10.712 52.256  1.00 53.43 ?  224  THR B CB  1 
ATOM   3344 O OG1 . THR C 1 1   ? -5.038  -11.163 53.298  1.00 51.92 ?  224  THR B OG1 1 
ATOM   3345 C CG2 . THR C 1 1   ? -7.214  -11.519 52.306  1.00 53.21 ?  224  THR B CG2 1 
ATOM   3346 N N   . LYS C 1 2   ? -6.092  -13.002 50.070  1.00 37.13 ?  225  LYS B N   1 
ATOM   3347 C CA  . LYS C 1 2   ? -5.984  -14.403 49.643  1.00 31.42 ?  225  LYS B CA  1 
ATOM   3348 C C   . LYS C 1 2   ? -4.991  -14.522 48.481  1.00 25.65 ?  225  LYS B C   1 
ATOM   3349 O O   . LYS C 1 2   ? -5.140  -13.797 47.484  1.00 26.89 ?  225  LYS B O   1 
ATOM   3350 C CB  . LYS C 1 2   ? -7.357  -14.931 49.246  1.00 29.32 ?  225  LYS B CB  1 
ATOM   3351 C CG  . LYS C 1 2   ? -7.339  -16.330 48.743  1.00 31.55 ?  225  LYS B CG  1 
ATOM   3352 C CD  . LYS C 1 2   ? -8.610  -16.620 47.973  1.00 32.50 ?  225  LYS B CD  1 
ATOM   3353 C CE  . LYS C 1 2   ? -8.879  -18.105 47.978  1.00 30.17 ?  225  LYS B CE  1 
ATOM   3354 N NZ  . LYS C 1 2   ? -10.352 -18.339 48.004  1.00 31.40 ?  225  LYS B NZ  1 
ATOM   3355 N N   . PRO C 1 3   ? -3.943  -15.346 48.591  1.00 24.66 ?  226  PRO B N   1 
ATOM   3356 C CA  . PRO C 1 3   ? -2.888  -15.320 47.561  1.00 22.17 ?  226  PRO B CA  1 
ATOM   3357 C C   . PRO C 1 3   ? -3.384  -15.910 46.248  1.00 18.71 ?  226  PRO B C   1 
ATOM   3358 O O   . PRO C 1 3   ? -4.101  -16.911 46.217  1.00 18.87 ?  226  PRO B O   1 
ATOM   3359 C CB  . PRO C 1 3   ? -1.740  -16.146 48.151  1.00 22.14 ?  226  PRO B CB  1 
ATOM   3360 C CG  . PRO C 1 3   ? -2.241  -16.648 49.503  1.00 30.95 ?  226  PRO B CG  1 
ATOM   3361 C CD  . PRO C 1 3   ? -3.659  -16.266 49.705  1.00 27.20 ?  226  PRO B CD  1 
ATOM   3362 N N   . PHE C 1 4   ? -3.011  -15.240 45.167  1.00 15.49 ?  227  PHE B N   1 
ATOM   3363 C CA  . PHE C 1 4   ? -3.286  -15.753 43.836  1.00 15.79 ?  227  PHE B CA  1 
ATOM   3364 C C   . PHE C 1 4   ? -2.389  -16.967 43.525  1.00 13.44 ?  227  PHE B C   1 
ATOM   3365 O O   . PHE C 1 4   ? -1.304  -17.151 44.094  1.00 13.42 ?  227  PHE B O   1 
ATOM   3366 C CB  . PHE C 1 4   ? -3.070  -14.607 42.824  1.00 13.83 ?  227  PHE B CB  1 
ATOM   3367 C CG  . PHE C 1 4   ? -3.296  -15.020 41.405  1.00 11.14 ?  227  PHE B CG  1 
ATOM   3368 C CD1 . PHE C 1 4   ? -4.602  -15.307 40.963  1.00 11.36 ?  227  PHE B CD1 1 
ATOM   3369 C CD2 . PHE C 1 4   ? -2.208  -15.171 40.540  1.00 11.69 ?  227  PHE B CD2 1 
ATOM   3370 C CE1 . PHE C 1 4   ? -4.825  -15.743 39.667  1.00 10.74 ?  227  PHE B CE1 1 
ATOM   3371 C CE2 . PHE C 1 4   ? -2.434  -15.596 39.210  1.00 12.91 ?  227  PHE B CE2 1 
ATOM   3372 C CZ  . PHE C 1 4   ? -3.749  -15.874 38.803  1.00 12.12 ?  227  PHE B CZ  1 
ATOM   3373 N N   . SER C 1 5   ? -2.850  -17.817 42.587  1.00 10.41 ?  228  SER B N   1 
ATOM   3374 C CA  . SER C 1 5   ? -2.121  -19.013 42.166  1.00 12.18 ?  228  SER B CA  1 
ATOM   3375 C C   . SER C 1 5   ? -2.763  -19.490 40.860  1.00 11.82 ?  228  SER B C   1 
ATOM   3376 O O   . SER C 1 5   ? -3.840  -19.019 40.491  1.00 10.37 ?  228  SER B O   1 
ATOM   3377 C CB  . SER C 1 5   ? -2.172  -20.139 43.210  1.00 13.90 ?  228  SER B CB  1 
ATOM   3378 O OG  . SER C 1 5   ? -3.510  -20.571 43.453  1.00 13.73 ?  228  SER B OG  1 
ATOM   3379 N N   . VAL C 1 6   ? -2.097  -20.425 40.181  1.00 11.72 ?  229  VAL B N   1 
ATOM   3380 C CA  . VAL C 1 6   ? -2.730  -21.147 39.073  1.00 10.33 ?  229  VAL B CA  1 
ATOM   3381 C C   . VAL C 1 6   ? -2.672  -22.628 39.408  1.00 11.76 ?  229  VAL B C   1 
ATOM   3382 O O   . VAL C 1 6   ? -1.827  -23.059 40.209  1.00 11.94 ?  229  VAL B O   1 
ATOM   3383 C CB  . VAL C 1 6   ? -2.065  -20.835 37.704  1.00 10.08 ?  229  VAL B CB  1 
ATOM   3384 C CG1 . VAL C 1 6   ? -2.218  -19.361 37.366  1.00 11.99 ?  229  VAL B CG1 1 
ATOM   3385 C CG2 . VAL C 1 6   ? -0.586  -21.241 37.667  1.00 12.24 ?  229  VAL B CG2 1 
ATOM   3386 N N   . PRO C 1 7   ? -3.530  -23.442 38.779  1.00 11.69 ?  230  PRO B N   1 
ATOM   3387 C CA  . PRO C 1 7   ? -3.538  -24.879 39.065  1.00 13.26 ?  230  PRO B CA  1 
ATOM   3388 C C   . PRO C 1 7   ? -2.239  -25.555 38.688  1.00 13.34 ?  230  PRO B C   1 
ATOM   3389 O O   . PRO C 1 7   ? -1.560  -25.174 37.732  1.00 12.86 ?  230  PRO B O   1 
ATOM   3390 C CB  . PRO C 1 7   ? -4.691  -25.422 38.205  1.00 15.37 ?  230  PRO B CB  1 
ATOM   3391 C CG  . PRO C 1 7   ? -5.495  -24.223 37.791  1.00 14.47 ?  230  PRO B CG  1 
ATOM   3392 C CD  . PRO C 1 7   ? -4.534  -23.048 37.774  1.00 11.17 ?  230  PRO B CD  1 
ATOM   3393 N N   . VAL C 1 8   ? -1.900  -26.561 39.495  1.00 12.69 ?  231  VAL B N   1 
ATOM   3394 C CA  . VAL C 1 8   ? -0.815  -27.487 39.189  1.00 13.15 ?  231  VAL B CA  1 
ATOM   3395 C C   . VAL C 1 8   ? -1.494  -28.554 38.327  1.00 15.86 ?  231  VAL B C   1 
ATOM   3396 O O   . VAL C 1 8   ? -1.992  -29.594 38.813  1.00 16.39 ?  231  VAL B O   1 
ATOM   3397 C CB  . VAL C 1 8   ? -0.182  -28.086 40.444  1.00 16.03 ?  231  VAL B CB  1 
ATOM   3398 C CG1 . VAL C 1 8   ? 0.837   -29.042 40.082  1.00 18.86 ?  231  VAL B CG1 1 
ATOM   3399 C CG2 . VAL C 1 8   ? 0.395   -26.998 41.340  1.00 14.87 ?  231  VAL B CG2 1 
ATOM   3400 N N   . LEU C 1 9   ? -1.525  -28.295 37.039  1.00 10.75 ?  232  LEU B N   1 
ATOM   3401 C CA  . LEU C 1 9   ? -2.002  -29.239 36.034  1.00 9.62  ?  232  LEU B CA  1 
ATOM   3402 C C   . LEU C 1 9   ? -1.132  -29.094 34.798  1.00 8.41  ?  232  LEU B C   1 
ATOM   3403 O O   . LEU C 1 9   ? -0.753  -27.967 34.431  1.00 10.78 ?  232  LEU B O   1 
ATOM   3404 C CB  . LEU C 1 9   ? -3.450  -28.948 35.629  1.00 9.95  ?  232  LEU B CB  1 
ATOM   3405 C CG  . LEU C 1 9   ? -4.529  -29.150 36.683  1.00 9.99  ?  232  LEU B CG  1 
ATOM   3406 C CD1 . LEU C 1 9   ? -5.924  -28.626 36.136  1.00 13.72 ?  232  LEU B CD1 1 
ATOM   3407 C CD2 . LEU C 1 9   ? -4.590  -30.632 37.045  1.00 14.47 ?  232  LEU B CD2 1 
ATOM   3408 N N   . THR C 1 10  ? -0.793  -30.219 34.180  1.00 8.11  ?  233  THR B N   1 
ATOM   3409 C CA  . THR C 1 10  ? -0.019  -30.134 32.947  1.00 8.39  ?  233  THR B CA  1 
ATOM   3410 C C   . THR C 1 10  ? -0.946  -29.696 31.795  1.00 7.67  ?  233  THR B C   1 
ATOM   3411 O O   . THR C 1 10  ? -2.166  -29.735 31.891  1.00 7.67  ?  233  THR B O   1 
ATOM   3412 C CB  . THR C 1 10  ? 0.597   -31.469 32.601  1.00 10.22 ?  233  THR B CB  1 
ATOM   3413 O OG1 . THR C 1 10  ? -0.457  -32.365 32.244  1.00 10.86 ?  233  THR B OG1 1 
ATOM   3414 C CG2 . THR C 1 10  ? 1.360   -32.024 33.785  1.00 11.09 ?  233  THR B CG2 1 
ATOM   3415 N N   . VAL C 1 11  ? -0.337  -29.334 30.672  1.00 7.68  ?  234  VAL B N   1 
ATOM   3416 C CA  . VAL C 1 11  ? -1.118  -28.965 29.475  1.00 6.42  ?  234  VAL B CA  1 
ATOM   3417 C C   . VAL C 1 11  ? -2.047  -30.102 29.068  1.00 7.27  ?  234  VAL B C   1 
ATOM   3418 O O   . VAL C 1 11  ? -3.262  -29.905 28.859  1.00 8.20  ?  234  VAL B O   1 
ATOM   3419 C CB  . VAL C 1 11  ? -0.161  -28.573 28.345  1.00 8.06  ?  234  VAL B CB  1 
ATOM   3420 C CG1 . VAL C 1 11  ? -0.934  -28.348 27.025  1.00 9.41  ?  234  VAL B CG1 1 
ATOM   3421 C CG2 . VAL C 1 11  ? 0.569   -27.253 28.744  1.00 10.03 ?  234  VAL B CG2 1 
ATOM   3422 N N   . GLU C 1 12  ? -1.504  -31.328 29.012  1.00 8.15  ?  235  GLU B N   1 
ATOM   3423 C CA  . GLU C 1 12  ? -2.312  -32.467 28.564  1.00 11.55 ?  235  GLU B CA  1 
ATOM   3424 C C   . GLU C 1 12  ? -3.402  -32.881 29.552  1.00 10.53 ?  235  GLU B C   1 
ATOM   3425 O O   . GLU C 1 12  ? -4.331  -33.627 29.186  1.00 11.12 ?  235  GLU B O   1 
ATOM   3426 C CB  . GLU C 1 12  ? -1.392  -33.646 28.267  1.00 13.22 ?  235  GLU B CB  1 
ATOM   3427 C CG  . GLU C 1 12  ? -0.682  -33.475 26.939  1.00 13.59 ?  235  GLU B CG  1 
ATOM   3428 C CD  . GLU C 1 12  ? 0.363   -34.590 26.685  1.00 17.36 ?  235  GLU B CD  1 
ATOM   3429 O OE1 . GLU C 1 12  ? 0.263   -35.673 27.357  1.00 15.75 ?  235  GLU B OE1 1 
ATOM   3430 O OE2 . GLU C 1 12  ? 1.288   -34.383 25.829  1.00 14.87 -1 235  GLU B OE2 1 
ATOM   3431 N N   . GLU C 1 13  ? -3.290  -32.454 30.815  1.00 8.45  ?  236  GLU B N   1 
ATOM   3432 C CA  . GLU C 1 13  ? -4.338  -32.699 31.789  1.00 7.51  ?  236  GLU B CA  1 
ATOM   3433 C C   . GLU C 1 13  ? -5.486  -31.712 31.657  1.00 9.93  ?  236  GLU B C   1 
ATOM   3434 O O   . GLU C 1 13  ? -6.511  -31.881 32.357  1.00 9.88  ?  236  GLU B O   1 
ATOM   3435 C CB  . GLU C 1 13  ? -3.747  -32.616 33.192  1.00 8.80  ?  236  GLU B CB  1 
ATOM   3436 C CG  . GLU C 1 13  ? -3.009  -33.889 33.582  1.00 10.88 ?  236  GLU B CG  1 
ATOM   3437 C CD  . GLU C 1 13  ? -2.241  -33.753 34.887  1.00 13.66 ?  236  GLU B CD  1 
ATOM   3438 O OE1 . GLU C 1 13  ? -1.953  -32.635 35.350  1.00 12.25 ?  236  GLU B OE1 1 
ATOM   3439 O OE2 . GLU C 1 13  ? -1.893  -34.812 35.461  1.00 14.88 -1 236  GLU B OE2 1 
ATOM   3440 N N   . MET C 1 14  ? -5.365  -30.707 30.778  1.00 6.93  ?  237  MET B N   1 
ATOM   3441 C CA  . MET C 1 14  ? -6.323  -29.625 30.791  1.00 6.63  ?  237  MET B CA  1 
ATOM   3442 C C   . MET C 1 14  ? -7.171  -29.676 29.494  1.00 7.87  ?  237  MET B C   1 
ATOM   3443 O O   . MET C 1 14  ? -6.994  -30.552 28.616  1.00 7.29  ?  237  MET B O   1 
ATOM   3444 C CB  . MET C 1 14  ? -5.556  -28.323 30.907  1.00 7.04  ?  237  MET B CB  1 
ATOM   3445 C CG  . MET C 1 14  ? -5.326  -28.082 32.389  1.00 7.46  ?  237  MET B CG  1 
ATOM   3446 S SD  . MET C 1 14  ? -4.586  -26.468 32.786  1.00 8.61  ?  237  MET B SD  1 
ATOM   3447 C CE  . MET C 1 14  ? -3.068  -26.381 31.821  1.00 10.06 ?  237  MET B CE  1 
ATOM   3448 N N   . THR C 1 15  ? -8.111  -28.722 29.360  1.00 5.93  ?  238  THR B N   1 
ATOM   3449 C CA  . THR C 1 15  ? -9.202  -28.794 28.372  1.00 6.20  ?  238  THR B CA  1 
ATOM   3450 C C   . THR C 1 15  ? -9.327  -27.481 27.639  1.00 6.13  ?  238  THR B C   1 
ATOM   3451 O O   . THR C 1 15  ? -9.200  -26.422 28.248  1.00 6.35  ?  238  THR B O   1 
ATOM   3452 C CB  . THR C 1 15  ? -10.545 -29.120 29.085  1.00 6.40  ?  238  THR B CB  1 
ATOM   3453 O OG1 . THR C 1 15  ? -10.378 -30.293 29.922  1.00 8.85  ?  238  THR B OG1 1 
ATOM   3454 C CG2 . THR C 1 15  ? -11.702 -29.372 28.073  1.00 7.54  ?  238  THR B CG2 1 
ATOM   3455 N N   . ASN C 1 16  ? -9.588  -27.537 26.332  1.00 6.19  ?  239  ASN B N   1 
ATOM   3456 C CA  . ASN C 1 16  ? -9.848  -26.307 25.600  1.00 5.34  ?  239  ASN B CA  1 
ATOM   3457 C C   . ASN C 1 16  ? -11.126 -25.650 26.129  1.00 6.28  ?  239  ASN B C   1 
ATOM   3458 O O   . ASN C 1 16  ? -12.099 -26.327 26.466  1.00 7.28  ?  239  ASN B O   1 
ATOM   3459 C CB  . ASN C 1 16  ? -9.974  -26.647 24.112  1.00 5.81  ?  239  ASN B CB  1 
ATOM   3460 C CG  . ASN C 1 16  ? -9.650  -25.441 23.206  1.00 5.09  ?  239  ASN B CG  1 
ATOM   3461 O OD1 . ASN C 1 16  ? -10.407 -24.449 23.147  1.00 5.54  ?  239  ASN B OD1 1 
ATOM   3462 N ND2 . ASN C 1 16  ? -8.496  -25.501 22.526  1.00 6.05  ?  239  ASN B ND2 1 
ATOM   3463 N N   . SER C 1 17  ? -11.120 -24.317 26.217  1.00 5.28  ?  240  SER B N   1 
ATOM   3464 C CA  . SER C 1 17  ? -12.290 -23.615 26.704  1.00 5.87  ?  240  SER B CA  1 
ATOM   3465 C C   . SER C 1 17  ? -13.184 -23.108 25.574  1.00 6.54  ?  240  SER B C   1 
ATOM   3466 O O   . SER C 1 17  ? -14.182 -22.424 25.851  1.00 8.12  ?  240  SER B O   1 
ATOM   3467 C CB  . SER C 1 17  ? -11.816 -22.436 27.590  1.00 5.99  ?  240  SER B CB  1 
ATOM   3468 O OG  . SER C 1 17  ? -10.881 -21.620 26.838  1.00 7.32  ?  240  SER B OG  1 
ATOM   3469 N N   . ARG C 1 18  ? -12.898 -23.497 24.320  1.00 6.42  ?  241  ARG B N   1 
ATOM   3470 C CA  . ARG C 1 18  ? -13.704 -23.086 23.175  1.00 6.10  ?  241  ARG B CA  1 
ATOM   3471 C C   . ARG C 1 18  ? -14.330 -24.244 22.399  1.00 6.49  ?  241  ARG B C   1 
ATOM   3472 O O   . ARG C 1 18  ? -15.136 -23.990 21.477  1.00 7.18  ?  241  ARG B O   1 
ATOM   3473 C CB  . ARG C 1 18  ? -12.824 -22.233 22.218  1.00 6.82  ?  241  ARG B CB  1 
ATOM   3474 C CG  . ARG C 1 18  ? -12.386 -20.877 22.830  1.00 7.14  ?  241  ARG B CG  1 
ATOM   3475 C CD  . ARG C 1 18  ? -11.485 -20.018 21.906  1.00 6.82  ?  241  ARG B CD  1 
ATOM   3476 N NE  . ARG C 1 18  ? -12.280 -19.548 20.772  1.00 6.90  ?  241  ARG B NE  1 
ATOM   3477 C CZ  . ARG C 1 18  ? -11.838 -19.420 19.526  1.00 6.39  ?  241  ARG B CZ  1 
ATOM   3478 N NH1 . ARG C 1 18  ? -10.547 -19.592 19.222  1.00 7.89  ?  241  ARG B NH1 1 
ATOM   3479 N NH2 . ARG C 1 18  ? -12.733 -19.176 18.538  1.00 7.91  ?  241  ARG B NH2 1 
ATOM   3480 N N   . PHE C 1 19  ? -14.035 -25.493 22.773  1.00 5.62  ?  242  PHE B N   1 
ATOM   3481 C CA  . PHE C 1 19  ? -14.650 -26.678 22.181  1.00 5.24  ?  242  PHE B CA  1 
ATOM   3482 C C   . PHE C 1 19  ? -14.344 -27.816 23.140  1.00 6.34  ?  242  PHE B C   1 
ATOM   3483 O O   . PHE C 1 19  ? -13.287 -27.789 23.774  1.00 5.71  ?  242  PHE B O   1 
ATOM   3484 C CB  . PHE C 1 19  ? -14.072 -26.922 20.764  1.00 5.60  ?  242  PHE B CB  1 
ATOM   3485 C CG  . PHE C 1 19  ? -14.915 -27.815 19.871  1.00 6.88  ?  242  PHE B CG  1 
ATOM   3486 C CD1 . PHE C 1 19  ? -15.959 -27.271 19.136  1.00 8.73  ?  242  PHE B CD1 1 
ATOM   3487 C CD2 . PHE C 1 19  ? -14.588 -29.176 19.700  1.00 7.27  ?  242  PHE B CD2 1 
ATOM   3488 C CE1 . PHE C 1 19  ? -16.748 -28.101 18.300  1.00 6.88  ?  242  PHE B CE1 1 
ATOM   3489 C CE2 . PHE C 1 19  ? -15.383 -30.012 18.861  1.00 8.63  ?  242  PHE B CE2 1 
ATOM   3490 C CZ  . PHE C 1 19  ? -16.458 -29.464 18.177  1.00 8.54  ?  242  PHE B CZ  1 
ATOM   3491 N N   . PRO C 1 20  ? -15.219 -28.779 23.298  1.00 7.19  ?  243  PRO B N   1 
ATOM   3492 C CA  . PRO C 1 20  ? -15.041 -29.830 24.354  1.00 6.23  ?  243  PRO B CA  1 
ATOM   3493 C C   . PRO C 1 20  ? -14.060 -30.942 23.986  1.00 7.80  ?  243  PRO B C   1 
ATOM   3494 O O   . PRO C 1 20  ? -14.428 -32.103 23.734  1.00 8.08  ?  243  PRO B O   1 
ATOM   3495 C CB  . PRO C 1 20  ? -16.463 -30.362 24.522  1.00 6.98  ?  243  PRO B CB  1 
ATOM   3496 C CG  . PRO C 1 20  ? -17.108 -30.166 23.167  1.00 8.99  ?  243  PRO B CG  1 
ATOM   3497 C CD  . PRO C 1 20  ? -16.556 -28.834 22.677  1.00 7.08  ?  243  PRO B CD  1 
ATOM   3498 N N   . ILE C 1 21  ? -12.772 -30.579 23.971  1.00 6.31  ?  244  ILE B N   1 
ATOM   3499 C CA  . ILE C 1 21  ? -11.656 -31.468 23.644  1.00 5.97  ?  244  ILE B CA  1 
ATOM   3500 C C   . ILE C 1 21  ? -10.469 -31.098 24.510  1.00 6.54  ?  244  ILE B C   1 
ATOM   3501 O O   . ILE C 1 21  ? -10.333 -29.946 24.958  1.00 6.98  ?  244  ILE B O   1 
ATOM   3502 C CB  . ILE C 1 21  ? -11.271 -31.393 22.158  1.00 5.50  ?  244  ILE B CB  1 
ATOM   3503 C CG1 . ILE C 1 21  ? -10.963 -29.943 21.756  1.00 6.52  ?  244  ILE B CG1 1 
ATOM   3504 C CG2 . ILE C 1 21  ? -12.439 -31.952 21.318  1.00 7.35  ?  244  ILE B CG2 1 
ATOM   3505 C CD1 . ILE C 1 21  ? -10.642 -29.740 20.184  1.00 8.79  ?  244  ILE B CD1 1 
ATOM   3506 N N   . PRO C 1 22  ? -9.563  -32.039 24.725  1.00 5.15  ?  245  PRO B N   1 
ATOM   3507 C CA  . PRO C 1 22  ? -8.388  -31.730 25.556  1.00 6.52  ?  245  PRO B CA  1 
ATOM   3508 C C   . PRO C 1 22  ? -7.435  -30.775 24.861  1.00 6.08  ?  245  PRO B C   1 
ATOM   3509 O O   . PRO C 1 22  ? -7.353  -30.669 23.629  1.00 6.31  ?  245  PRO B O   1 
ATOM   3510 C CB  . PRO C 1 22  ? -7.706  -33.093 25.797  1.00 8.12  ?  245  PRO B CB  1 
ATOM   3511 C CG  . PRO C 1 22  ? -8.299  -34.013 24.752  1.00 11.20 ?  245  PRO B CG  1 
ATOM   3512 C CD  . PRO C 1 22  ? -9.644  -33.475 24.377  1.00 7.35  ?  245  PRO B CD  1 
ATOM   3513 N N   . LEU C 1 23  ? -6.653  -30.089 25.705  1.00 6.15  ?  246  LEU B N   1 
ATOM   3514 C CA  . LEU C 1 23  ? -5.509  -29.333 25.177  1.00 6.04  ?  246  LEU B CA  1 
ATOM   3515 C C   . LEU C 1 23  ? -4.427  -30.288 24.701  1.00 6.70  ?  246  LEU B C   1 
ATOM   3516 O O   . LEU C 1 23  ? -4.260  -31.415 25.223  1.00 7.84  ?  246  LEU B O   1 
ATOM   3517 C CB  . LEU C 1 23  ? -4.891  -28.439 26.270  1.00 6.76  ?  246  LEU B CB  1 
ATOM   3518 C CG  . LEU C 1 23  ? -5.778  -27.286 26.745  1.00 7.54  ?  246  LEU B CG  1 
ATOM   3519 C CD1 . LEU C 1 23  ? -4.880  -26.445 27.733  1.00 7.51  ?  246  LEU B CD1 1 
ATOM   3520 C CD2 . LEU C 1 23  ? -6.216  -26.415 25.556  1.00 7.21  ?  246  LEU B CD2 1 
ATOM   3521 N N   . GLU C 1 24  ? -3.714  -29.851 23.692  1.00 5.96  ?  247  GLU B N   1 
ATOM   3522 C CA  . GLU C 1 24  ? -2.608  -30.633 23.158  1.00 7.13  ?  247  GLU B CA  1 
ATOM   3523 C C   . GLU C 1 24  ? -1.260  -29.970 23.317  1.00 7.46  ?  247  GLU B C   1 
ATOM   3524 O O   . GLU C 1 24  ? -0.275  -30.694 23.542  1.00 8.55  ?  247  GLU B O   1 
ATOM   3525 C CB  . GLU C 1 24  ? -2.817  -30.914 21.667  1.00 8.06  ?  247  GLU B CB  1 
ATOM   3526 C CG  . GLU C 1 24  ? -4.111  -31.721 21.420  1.00 7.93  ?  247  GLU B CG  1 
ATOM   3527 C CD  . GLU C 1 24  ? -4.613  -31.592 19.973  1.00 12.99 ?  247  GLU B CD  1 
ATOM   3528 O OE1 . GLU C 1 24  ? -3.835  -31.131 19.088  1.00 11.82 ?  247  GLU B OE1 1 
ATOM   3529 O OE2 . GLU C 1 24  ? -5.808  -31.926 19.724  1.00 11.73 -1 247  GLU B OE2 1 
ATOM   3530 N N   . LYS C 1 25  ? -1.173  -28.653 23.133  1.00 7.37  ?  248  LYS B N   1 
ATOM   3531 C CA  . LYS C 1 25  ? 0.133   -28.004 23.116  1.00 7.86  ?  248  LYS B CA  1 
ATOM   3532 C C   . LYS C 1 25  ? -0.014  -26.512 23.346  1.00 8.30  ?  248  LYS B C   1 
ATOM   3533 O O   . LYS C 1 25  ? -1.096  -25.937 23.225  1.00 7.93  ?  248  LYS B O   1 
ATOM   3534 C CB  . LYS C 1 25  ? 0.870   -28.246 21.801  1.00 11.78 ?  248  LYS B CB  1 
ATOM   3535 C CG  . LYS C 1 25  ? 0.147   -27.775 20.619  1.00 11.91 ?  248  LYS B CG  1 
ATOM   3536 C CD  . LYS C 1 25  ? 0.739   -28.596 19.416  1.00 16.63 ?  248  LYS B CD  1 
ATOM   3537 C CE  . LYS C 1 25  ? -0.081  -28.422 18.175  1.00 20.90 ?  248  LYS B CE  1 
ATOM   3538 N NZ  . LYS C 1 25  ? 0.705   -29.033 17.015  1.00 22.14 ?  248  LYS B NZ  1 
ATOM   3539 N N   . LEU C 1 26  ? 1.120   -25.882 23.642  1.00 5.34  ?  249  LEU B N   1 
ATOM   3540 C CA  . LEU C 1 26  ? 1.213   -24.432 23.680  1.00 5.99  ?  249  LEU B CA  1 
ATOM   3541 C C   . LEU C 1 26  ? 1.728   -23.932 22.326  1.00 7.23  ?  249  LEU B C   1 
ATOM   3542 O O   . LEU C 1 26  ? 2.665   -24.511 21.746  1.00 9.66  ?  249  LEU B O   1 
ATOM   3543 C CB  . LEU C 1 26  ? 2.162   -23.958 24.796  1.00 5.88  ?  249  LEU B CB  1 
ATOM   3544 C CG  . LEU C 1 26  ? 1.832   -24.478 26.176  1.00 7.92  ?  249  LEU B CG  1 
ATOM   3545 C CD1 . LEU C 1 26  ? 2.914   -24.085 27.154  1.00 8.62  ?  249  LEU B CD1 1 
ATOM   3546 C CD2 . LEU C 1 26  ? 0.462   -23.917 26.653  1.00 7.58  ?  249  LEU B CD2 1 
ATOM   3547 N N   . PHE C 1 27  ? 1.114   -22.873 21.814  1.00 6.71  ?  250  PHE B N   1 
ATOM   3548 C CA  . PHE C 1 27  ? 1.486   -22.314 20.526  1.00 7.18  ?  250  PHE B CA  1 
ATOM   3549 C C   . PHE C 1 27  ? 1.587   -20.796 20.620  1.00 8.47  ?  250  PHE B C   1 
ATOM   3550 O O   . PHE C 1 27  ? 0.736   -20.155 21.237  1.00 7.97  ?  250  PHE B O   1 
ATOM   3551 C CB  . PHE C 1 27  ? 0.420   -22.719 19.445  1.00 7.64  ?  250  PHE B CB  1 
ATOM   3552 C CG  . PHE C 1 27  ? 0.635   -22.021 18.133  1.00 8.39  ?  250  PHE B CG  1 
ATOM   3553 C CD1 . PHE C 1 27  ? 1.581   -22.503 17.223  1.00 8.71  ?  250  PHE B CD1 1 
ATOM   3554 C CD2 . PHE C 1 27  ? -0.115  -20.867 17.812  1.00 9.45  ?  250  PHE B CD2 1 
ATOM   3555 C CE1 . PHE C 1 27  ? 1.777   -21.836 15.999  1.00 11.78 ?  250  PHE B CE1 1 
ATOM   3556 C CE2 . PHE C 1 27  ? 0.071   -20.217 16.577  1.00 10.45 ?  250  PHE B CE2 1 
ATOM   3557 C CZ  . PHE C 1 27  ? 1.044   -20.696 15.679  1.00 12.20 ?  250  PHE B CZ  1 
ATOM   3558 N N   . THR C 1 28  ? 2.598   -20.209 19.963  1.00 6.40  ?  251  THR B N   1 
ATOM   3559 C CA  . THR C 1 28  ? 2.690   -18.756 19.894  1.00 8.56  ?  251  THR B CA  1 
ATOM   3560 C C   . THR C 1 28  ? 2.943   -18.339 18.451  1.00 8.68  ?  251  THR B C   1 
ATOM   3561 O O   . THR C 1 28  ? 3.605   -19.050 17.691  1.00 8.45  ?  251  THR B O   1 
ATOM   3562 C CB  . THR C 1 28  ? 3.789   -18.202 20.849  1.00 8.31  ?  251  THR B CB  1 
ATOM   3563 O OG1 . THR C 1 28  ? 3.703   -16.756 20.827  1.00 7.50  ?  251  THR B OG1 1 
ATOM   3564 C CG2 . THR C 1 28  ? 5.194   -18.626 20.361  1.00 9.73  ?  251  THR B CG2 1 
ATOM   3565 N N   . GLY C 1 29  ? 2.374   -17.201 18.067  1.00 8.70  ?  252  GLY B N   1 
ATOM   3566 C CA  . GLY C 1 29  ? 2.636   -16.594 16.762  1.00 10.10 ?  252  GLY B CA  1 
ATOM   3567 C C   . GLY C 1 29  ? 2.159   -15.152 16.756  1.00 10.92 ?  252  GLY B C   1 
ATOM   3568 O O   . GLY C 1 29  ? 1.468   -14.721 17.677  1.00 9.75  ?  252  GLY B O   1 
ATOM   3569 N N   . PRO C 1 30  ? 2.539   -14.379 15.728  1.00 11.46 ?  253  PRO B N   1 
ATOM   3570 C CA  . PRO C 1 30  ? 2.010   -13.011 15.593  1.00 11.09 ?  253  PRO B CA  1 
ATOM   3571 C C   . PRO C 1 30  ? 0.512   -13.041 15.328  1.00 11.72 ?  253  PRO B C   1 
ATOM   3572 O O   . PRO C 1 30  ? -0.015  -13.981 14.725  1.00 16.10 ?  253  PRO B O   1 
ATOM   3573 C CB  . PRO C 1 30  ? 2.772   -12.436 14.389  1.00 15.77 ?  253  PRO B CB  1 
ATOM   3574 C CG  . PRO C 1 30  ? 3.387   -13.590 13.694  1.00 18.94 ?  253  PRO B CG  1 
ATOM   3575 C CD  . PRO C 1 30  ? 3.400   -14.801 14.607  1.00 14.19 ?  253  PRO B CD  1 
ATOM   3576 N N   . SER C 1 31  ? -0.167  -11.972 15.776  1.00 13.50 ?  254  SER B N   1 
ATOM   3577 C CA  . SER C 1 31  ? -1.609  -11.875 15.595  1.00 12.45 ?  254  SER B CA  1 
ATOM   3578 C C   . SER C 1 31  ? -2.040  -10.509 15.081  1.00 21.14 ?  254  SER B C   1 
ATOM   3579 O O   . SER C 1 31  ? -3.229  -10.164 15.199  1.00 21.42 ?  254  SER B O   1 
ATOM   3580 C CB  . SER C 1 31  ? -2.313  -12.215 16.921  1.00 15.13 ?  254  SER B CB  1 
ATOM   3581 O OG  . SER C 1 31  ? -1.841  -11.400 18.004  1.00 17.45 ?  254  SER B OG  1 
ATOM   3582 N N   . SER C 1 32  ? -1.125  -9.736  14.476  1.00 19.56 ?  255  SER B N   1 
ATOM   3583 C CA  . SER C 1 32  ? -1.587  -8.453  13.965  1.00 22.47 ?  255  SER B CA  1 
ATOM   3584 C C   . SER C 1 32  ? -2.459  -8.580  12.703  1.00 24.03 ?  255  SER B C   1 
ATOM   3585 O O   . SER C 1 32  ? -3.206  -7.652  12.399  1.00 28.82 ?  255  SER B O   1 
ATOM   3586 C CB  . SER C 1 32  ? -0.388  -7.528  13.743  1.00 25.65 ?  255  SER B CB  1 
ATOM   3587 O OG  . SER C 1 32  ? 0.594   -8.140  12.946  1.00 28.06 ?  255  SER B OG  1 
ATOM   3588 N N   . ALA C 1 33  ? -2.445  -9.709  12.004  1.00 25.02 ?  256  ALA B N   1 
ATOM   3589 C CA  . ALA C 1 33  ? -3.293  -9.897  10.828  1.00 27.58 ?  256  ALA B CA  1 
ATOM   3590 C C   . ALA C 1 33  ? -4.746  -10.217 11.171  1.00 28.84 ?  256  ALA B C   1 
ATOM   3591 O O   . ALA C 1 33  ? -5.568  -10.425 10.257  1.00 29.83 ?  256  ALA B O   1 
ATOM   3592 C CB  . ALA C 1 33  ? -2.732  -11.017 9.950   1.00 30.42 ?  256  ALA B CB  1 
ATOM   3593 N N   . PHE C 1 34  ? -5.114  -10.281 12.447  1.00 23.56 ?  257  PHE B N   1 
ATOM   3594 C CA  . PHE C 1 34  ? -6.486  -10.658 12.745  1.00 23.13 ?  257  PHE B CA  1 
ATOM   3595 C C   . PHE C 1 34  ? -6.844  -10.081 14.104  1.00 18.50 ?  257  PHE B C   1 
ATOM   3596 O O   . PHE C 1 34  ? -5.996  -9.505  14.802  1.00 17.03 ?  257  PHE B O   1 
ATOM   3597 C CB  . PHE C 1 34  ? -6.661  -12.180 12.625  1.00 25.36 ?  257  PHE B CB  1 
ATOM   3598 C CG  . PHE C 1 34  ? -5.603  -12.962 13.303  1.00 22.43 ?  257  PHE B CG  1 
ATOM   3599 C CD1 . PHE C 1 34  ? -4.511  -13.461 12.590  1.00 21.52 ?  257  PHE B CD1 1 
ATOM   3600 C CD2 . PHE C 1 34  ? -5.741  -13.303 14.619  1.00 23.51 ?  257  PHE B CD2 1 
ATOM   3601 C CE1 . PHE C 1 34  ? -3.495  -14.173 13.222  1.00 23.02 ?  257  PHE B CE1 1 
ATOM   3602 C CE2 . PHE C 1 34  ? -4.764  -14.052 15.263  1.00 22.13 ?  257  PHE B CE2 1 
ATOM   3603 C CZ  . PHE C 1 34  ? -3.621  -14.502 14.561  1.00 22.41 ?  257  PHE B CZ  1 
ATOM   3604 N N   . VAL C 1 35  ? -8.129  -10.146 14.431  1.00 15.12 ?  258  VAL B N   1 
ATOM   3605 C CA  . VAL C 1 35  ? -8.657  -9.621  15.686  1.00 13.47 ?  258  VAL B CA  1 
ATOM   3606 C C   . VAL C 1 35  ? -8.858  -10.824 16.587  1.00 14.62 ?  258  VAL B C   1 
ATOM   3607 O O   . VAL C 1 35  ? -9.606  -11.742 16.243  1.00 15.81 ?  258  VAL B O   1 
ATOM   3608 C CB  . VAL C 1 35  ? -9.980  -8.859  15.475  1.00 15.26 ?  258  VAL B CB  1 
ATOM   3609 C CG1 . VAL C 1 35  ? -10.572 -8.423  16.789  1.00 17.15 ?  258  VAL B CG1 1 
ATOM   3610 C CG2 . VAL C 1 35  ? -9.754  -7.614  14.547  1.00 20.35 ?  258  VAL B CG2 1 
ATOM   3611 N N   . VAL C 1 36  ? -8.211  -10.850 17.740  1.00 10.43 ?  259  VAL B N   1 
ATOM   3612 C CA  . VAL C 1 36  ? -8.326  -11.977 18.657  1.00 9.40  ?  259  VAL B CA  1 
ATOM   3613 C C   . VAL C 1 36  ? -9.358  -11.577 19.714  1.00 10.64 ?  259  VAL B C   1 
ATOM   3614 O O   . VAL C 1 36  ? -9.034  -10.939 20.732  1.00 10.19 ?  259  VAL B O   1 
ATOM   3615 C CB  . VAL C 1 36  ? -6.957  -12.328 19.256  1.00 11.14 ?  259  VAL B CB  1 
ATOM   3616 C CG1 . VAL C 1 36  ? -7.088  -13.458 20.294  1.00 8.68  ?  259  VAL B CG1 1 
ATOM   3617 C CG2 . VAL C 1 36  ? -5.994  -12.700 18.129  1.00 12.52 ?  259  VAL B CG2 1 
ATOM   3618 N N   . GLN C 1 37  ? -10.614 -12.032 19.532  1.00 8.08  ?  260  GLN B N   1 
ATOM   3619 C CA  . GLN C 1 37  ? -11.688 -11.650 20.434  1.00 8.12  ?  260  GLN B CA  1 
ATOM   3620 C C   . GLN C 1 37  ? -12.619 -12.832 20.717  1.00 9.31  ?  260  GLN B C   1 
ATOM   3621 O O   . GLN C 1 37  ? -13.837 -12.710 20.575  1.00 8.68  ?  260  GLN B O   1 
ATOM   3622 C CB  . GLN C 1 37  ? -12.471 -10.469 19.820  1.00 10.59 ?  260  GLN B CB  1 
ATOM   3623 C CG  . GLN C 1 37  ? -13.391 -9.717  20.791  1.00 11.48 ?  260  GLN B CG  1 
ATOM   3624 C CD  . GLN C 1 37  ? -13.877 -8.380  20.275  1.00 12.22 ?  260  GLN B CD  1 
ATOM   3625 O OE1 . GLN C 1 37  ? -13.688 -8.010  19.082  1.00 14.23 ?  260  GLN B OE1 1 
ATOM   3626 N NE2 . GLN C 1 37  ? -14.542 -7.646  21.178  1.00 13.15 ?  260  GLN B NE2 1 
ATOM   3627 N N   . PRO C 1 38  ? -12.091 -13.991 21.118  1.00 6.61  ?  261  PRO B N   1 
ATOM   3628 C CA  . PRO C 1 38  ? -12.989 -15.105 21.466  1.00 7.39  ?  261  PRO B CA  1 
ATOM   3629 C C   . PRO C 1 38  ? -13.869 -14.744 22.661  1.00 8.11  ?  261  PRO B C   1 
ATOM   3630 O O   . PRO C 1 38  ? -13.514 -13.907 23.517  1.00 7.46  ?  261  PRO B O   1 
ATOM   3631 C CB  . PRO C 1 38  ? -12.002 -16.250 21.809  1.00 7.88  ?  261  PRO B CB  1 
ATOM   3632 C CG  . PRO C 1 38  ? -10.747 -15.441 22.392  1.00 7.47  ?  261  PRO B CG  1 
ATOM   3633 C CD  . PRO C 1 38  ? -10.686 -14.228 21.493  1.00 7.97  ?  261  PRO B CD  1 
ATOM   3634 N N   . GLN C 1 39  ? -15.039 -15.371 22.736  1.00 7.80  ?  262  GLN B N   1 
ATOM   3635 C CA  . GLN C 1 39  ? -15.982 -15.125 23.819  1.00 7.07  ?  262  GLN B CA  1 
ATOM   3636 C C   . GLN C 1 39  ? -16.112 -16.263 24.817  1.00 6.93  ?  262  GLN B C   1 
ATOM   3637 O O   . GLN C 1 39  ? -16.537 -16.026 25.960  1.00 8.79  ?  262  GLN B O   1 
ATOM   3638 C CB  . GLN C 1 39  ? -17.376 -14.835 23.230  1.00 7.93  ?  262  GLN B CB  1 
ATOM   3639 C CG  . GLN C 1 39  ? -17.283 -13.615 22.289  1.00 7.40  ?  262  GLN B CG  1 
ATOM   3640 C CD  . GLN C 1 39  ? -16.863 -12.320 23.090  1.00 8.40  ?  262  GLN B CD  1 
ATOM   3641 O OE1 . GLN C 1 39  ? -17.524 -11.977 24.078  1.00 10.13 ?  262  GLN B OE1 1 
ATOM   3642 N NE2 . GLN C 1 39  ? -15.792 -11.655 22.650  1.00 9.30  ?  262  GLN B NE2 1 
ATOM   3643 N N   . ASN C 1 40  ? -15.762 -17.499 24.419  1.00 7.72  ?  263  ASN B N   1 
ATOM   3644 C CA  . ASN C 1 40  ? -15.558 -18.582 25.376  1.00 7.38  ?  263  ASN B CA  1 
ATOM   3645 C C   . ASN C 1 40  ? -14.105 -18.610 25.866  1.00 5.95  ?  263  ASN B C   1 
ATOM   3646 O O   . ASN C 1 40  ? -13.188 -18.131 25.175  1.00 9.07  ?  263  ASN B O   1 
ATOM   3647 C CB  . ASN C 1 40  ? -15.939 -19.915 24.720  1.00 7.66  ?  263  ASN B CB  1 
ATOM   3648 C CG  . ASN C 1 40  ? -17.465 -20.014 24.471  1.00 7.47  ?  263  ASN B CG  1 
ATOM   3649 O OD1 . ASN C 1 40  ? -18.249 -19.681 25.374  1.00 8.56  ?  263  ASN B OD1 1 
ATOM   3650 N ND2 . ASN C 1 40  ? -17.869 -20.487 23.284  1.00 6.75  ?  263  ASN B ND2 1 
ATOM   3651 N N   . GLY C 1 41  ? -13.919 -19.090 27.099  1.00 7.64  ?  264  GLY B N   1 
ATOM   3652 C CA  . GLY C 1 41  ? -12.574 -19.106 27.659  1.00 7.22  ?  264  GLY B CA  1 
ATOM   3653 C C   . GLY C 1 41  ? -12.120 -17.734 28.106  1.00 8.37  ?  264  GLY B C   1 
ATOM   3654 O O   . GLY C 1 41  ? -10.941 -17.406 27.982  1.00 7.60  ?  264  GLY B O   1 
ATOM   3655 N N   . ARG C 1 42  ? -13.045 -16.912 28.585  1.00 8.89  ?  265  ARG B N   1 
ATOM   3656 C CA  . ARG C 1 42  ? -12.773 -15.552 29.022  1.00 7.19  ?  265  ARG B CA  1 
ATOM   3657 C C   . ARG C 1 42  ? -13.144 -15.386 30.490  1.00 9.68  ?  265  ARG B C   1 
ATOM   3658 O O   . ARG C 1 42  ? -14.292 -15.632 30.884  1.00 9.19  ?  265  ARG B O   1 
ATOM   3659 C CB  . ARG C 1 42  ? -13.536 -14.536 28.154  1.00 8.47  ?  265  ARG B CB  1 
ATOM   3660 C CG  . ARG C 1 42  ? -13.214 -14.651 26.631  1.00 8.24  ?  265  ARG B CG  1 
ATOM   3661 C CD  . ARG C 1 42  ? -11.723 -14.322 26.243  1.00 6.97  ?  265  ARG B CD  1 
ATOM   3662 N NE  . ARG C 1 42  ? -11.311 -12.984 26.677  1.00 8.10  ?  265  ARG B NE  1 
ATOM   3663 C CZ  . ARG C 1 42  ? -11.323 -11.916 25.893  1.00 9.71  ?  265  ARG B CZ  1 
ATOM   3664 N NH1 . ARG C 1 42  ? -11.713 -11.977 24.592  1.00 8.39  ?  265  ARG B NH1 1 
ATOM   3665 N NH2 . ARG C 1 42  ? -10.912 -10.752 26.404  1.00 10.34 ?  265  ARG B NH2 1 
ATOM   3666 N N   . CYS C 1 43  ? -12.154 -14.971 31.293  1.00 9.16  ?  266  CYS B N   1 
ATOM   3667 C CA  . CYS C 1 43  ? -12.292 -14.880 32.748  1.00 7.57  ?  266  CYS B CA  1 
ATOM   3668 C C   . CYS C 1 43  ? -11.156 -14.027 33.304  1.00 8.69  ?  266  CYS B C   1 
ATOM   3669 O O   . CYS C 1 43  ? -10.010 -14.126 32.831  1.00 9.69  ?  266  CYS B O   1 
ATOM   3670 C CB  . CYS C 1 43  ? -12.234 -16.285 33.367  1.00 9.02  ?  266  CYS B CB  1 
ATOM   3671 S SG  . CYS C 1 43  ? -12.603 -16.349 35.175  1.00 11.38 ?  266  CYS B SG  1 
ATOM   3672 N N   . THR C 1 44  ? -11.474 -13.161 34.293  1.00 9.31  ?  267  THR B N   1 
ATOM   3673 C CA  . THR C 1 44  ? -10.375 -12.407 34.884  1.00 9.74  ?  267  THR B CA  1 
ATOM   3674 C C   . THR C 1 44  ? -9.645  -13.255 35.926  1.00 10.43 ?  267  THR B C   1 
ATOM   3675 O O   . THR C 1 44  ? -10.153 -14.275 36.419  1.00 9.88  ?  267  THR B O   1 
ATOM   3676 C CB  . THR C 1 44  ? -10.906 -11.136 35.551  1.00 11.19 ?  267  THR B CB  1 
ATOM   3677 O OG1 . THR C 1 44  ? -11.679 -11.506 36.712  1.00 12.28 ?  267  THR B OG1 1 
ATOM   3678 C CG2 . THR C 1 44  ? -11.747 -10.318 34.558  1.00 12.30 ?  267  THR B CG2 1 
ATOM   3679 N N   . THR C 1 45  ? -8.423  -12.829 36.279  1.00 9.87  ?  268  THR B N   1 
ATOM   3680 C CA  . THR C 1 45  ? -7.695  -13.624 37.264  1.00 9.81  ?  268  THR B CA  1 
ATOM   3681 C C   . THR C 1 45  ? -8.375  -13.605 38.637  1.00 13.23 ?  268  THR B C   1 
ATOM   3682 O O   . THR C 1 45  ? -8.160  -14.546 39.403  1.00 10.63 ?  268  THR B O   1 
ATOM   3683 C CB  . THR C 1 45  ? -6.242  -13.167 37.398  1.00 9.32  ?  268  THR B CB  1 
ATOM   3684 O OG1 . THR C 1 45  ? -6.191  -11.779 37.789  1.00 11.86 ?  268  THR B OG1 1 
ATOM   3685 C CG2 . THR C 1 45  ? -5.498  -13.284 36.042  1.00 10.32 ?  268  THR B CG2 1 
ATOM   3686 N N   . ASP C 1 46  ? -9.195  -12.585 38.946  1.00 11.66 ?  269  ASP B N   1 
ATOM   3687 C CA  . ASP C 1 46  ? -9.945  -12.625 40.198  1.00 13.71 ?  269  ASP B CA  1 
ATOM   3688 C C   . ASP C 1 46  ? -11.339 -13.217 40.042  1.00 14.24 ?  269  ASP B C   1 
ATOM   3689 O O   . ASP C 1 46  ? -12.172 -13.081 40.959  1.00 14.70 ?  269  ASP B O   1 
ATOM   3690 C CB  . ASP C 1 46  ? -9.975  -11.237 40.872  1.00 14.26 ?  269  ASP B CB  1 
ATOM   3691 C CG  . ASP C 1 46  ? -10.491 -10.103 39.980  1.00 20.20 ?  269  ASP B CG  1 
ATOM   3692 O OD1 . ASP C 1 46  ? -10.766 -10.223 38.755  1.00 16.64 ?  269  ASP B OD1 1 
ATOM   3693 O OD2 . ASP C 1 46  ? -10.596 -8.981  40.545  1.00 23.47 -1 269  ASP B OD2 1 
ATOM   3694 N N   . GLY C 1 47  ? -11.596 -13.951 38.950  1.00 11.23 ?  270  GLY B N   1 
ATOM   3695 C CA  . GLY C 1 47  ? -12.736 -14.851 38.931  1.00 12.53 ?  270  GLY B CA  1 
ATOM   3696 C C   . GLY C 1 47  ? -14.018 -14.302 38.339  1.00 12.03 ?  270  GLY B C   1 
ATOM   3697 O O   . GLY C 1 47  ? -15.098 -14.875 38.588  1.00 13.93 ?  270  GLY B O   1 
ATOM   3698 N N   . VAL C 1 48  ? -13.952 -13.245 37.540  1.00 10.40 ?  271  VAL B N   1 
ATOM   3699 C CA  . VAL C 1 48  ? -15.144 -12.711 36.881  1.00 11.24 ?  271  VAL B CA  1 
ATOM   3700 C C   . VAL C 1 48  ? -15.233 -13.304 35.476  1.00 10.91 ?  271  VAL B C   1 
ATOM   3701 O O   . VAL C 1 48  ? -14.369 -13.044 34.624  1.00 11.51 ?  271  VAL B O   1 
ATOM   3702 C CB  . VAL C 1 48  ? -15.099 -11.182 36.812  1.00 12.85 ?  271  VAL B CB  1 
ATOM   3703 C CG1 . VAL C 1 48  ? -16.369 -10.641 36.195  1.00 14.26 ?  271  VAL B CG1 1 
ATOM   3704 C CG2 . VAL C 1 48  ? -14.931 -10.633 38.247  1.00 14.42 ?  271  VAL B CG2 1 
ATOM   3705 N N   . LEU C 1 49  ? -16.297 -14.070 35.224  1.00 12.43 ?  272  LEU B N   1 
ATOM   3706 C CA  . LEU C 1 49  ? -16.522 -14.624 33.891  1.00 11.35 ?  272  LEU B CA  1 
ATOM   3707 C C   . LEU C 1 49  ? -16.894 -13.521 32.899  1.00 13.50 ?  272  LEU B C   1 
ATOM   3708 O O   . LEU C 1 49  ? -17.659 -12.595 33.232  1.00 13.70 ?  272  LEU B O   1 
ATOM   3709 C CB  . LEU C 1 49  ? -17.626 -15.681 33.927  1.00 11.22 ?  272  LEU B CB  1 
ATOM   3710 C CG  . LEU C 1 49  ? -17.409 -16.802 34.928  1.00 12.95 ?  272  LEU B CG  1 
ATOM   3711 C CD1 . LEU C 1 49  ? -18.638 -17.713 34.900  1.00 16.71 ?  272  LEU B CD1 1 
ATOM   3712 C CD2 . LEU C 1 49  ? -16.201 -17.606 34.541  1.00 12.33 ?  272  LEU B CD2 1 
ATOM   3713 N N   . LEU C 1 50  ? -16.416 -13.638 31.654  1.00 10.19 ?  273  LEU B N   1 
ATOM   3714 C CA  . LEU C 1 50  ? -16.668 -12.638 30.616  1.00 9.32  ?  273  LEU B CA  1 
ATOM   3715 C C   . LEU C 1 50  ? -17.287 -13.272 29.363  1.00 11.09 ?  273  LEU B C   1 
ATOM   3716 O O   . LEU C 1 50  ? -17.260 -14.490 29.181  1.00 9.83  ?  273  LEU B O   1 
ATOM   3717 C CB  . LEU C 1 50  ? -15.387 -11.889 30.204  1.00 10.88 ?  273  LEU B CB  1 
ATOM   3718 C CG  . LEU C 1 50  ? -14.477 -11.376 31.308  1.00 10.47 ?  273  LEU B CG  1 
ATOM   3719 C CD1 . LEU C 1 50  ? -13.127 -10.925 30.750  1.00 11.66 ?  273  LEU B CD1 1 
ATOM   3720 C CD2 . LEU C 1 50  ? -15.184 -10.181 32.039  1.00 14.74 ?  273  LEU B CD2 1 
ATOM   3721 N N   . GLY C 1 51  ? -17.790 -12.428 28.455  1.00 10.12 ?  274  GLY B N   1 
ATOM   3722 C CA  . GLY C 1 51  ? -18.223 -12.952 27.148  1.00 9.84  ?  274  GLY B CA  1 
ATOM   3723 C C   . GLY C 1 51  ? -19.358 -13.946 27.298  1.00 12.06 ?  274  GLY B C   1 
ATOM   3724 O O   . GLY C 1 51  ? -20.367 -13.690 27.982  1.00 11.93 ?  274  GLY B O   1 
ATOM   3725 N N   . THR C 1 52  ? -19.251 -15.093 26.604  1.00 8.87  ?  275  THR B N   1 
ATOM   3726 C CA  . THR C 1 52  ? -20.212 -16.177 26.740  1.00 9.03  ?  275  THR B CA  1 
ATOM   3727 C C   . THR C 1 52  ? -19.691 -17.311 27.624  1.00 9.27  ?  275  THR B C   1 
ATOM   3728 O O   . THR C 1 52  ? -20.134 -18.451 27.483  1.00 9.10  ?  275  THR B O   1 
ATOM   3729 C CB  . THR C 1 52  ? -20.624 -16.717 25.345  1.00 8.48  ?  275  THR B CB  1 
ATOM   3730 O OG1 . THR C 1 52  ? -19.455 -17.211 24.679  1.00 8.34  ?  275  THR B OG1 1 
ATOM   3731 C CG2 . THR C 1 52  ? -21.280 -15.617 24.472  1.00 10.14 ?  275  THR B CG2 1 
ATOM   3732 N N   . THR C 1 53  ? -18.731 -17.045 28.517  1.00 7.59  ?  276  THR B N   1 
ATOM   3733 C CA  . THR C 1 53  ? -18.030 -18.128 29.219  1.00 7.40  ?  276  THR B CA  1 
ATOM   3734 C C   . THR C 1 53  ? -18.854 -18.658 30.375  1.00 9.88  ?  276  THR B C   1 
ATOM   3735 O O   . THR C 1 53  ? -19.391 -17.884 31.206  1.00 11.15 ?  276  THR B O   1 
ATOM   3736 C CB  . THR C 1 53  ? -16.665 -17.617 29.689  1.00 9.12  ?  276  THR B CB  1 
ATOM   3737 O OG1 . THR C 1 53  ? -15.933 -17.294 28.521  1.00 9.75  ?  276  THR B OG1 1 
ATOM   3738 C CG2 . THR C 1 53  ? -15.883 -18.665 30.515  1.00 8.25  ?  276  THR B CG2 1 
ATOM   3739 N N   . GLN C 1 54  ? -18.929 -19.984 30.443  1.00 7.97  ?  277  GLN B N   1 
ATOM   3740 C CA  . GLN C 1 54  ? -19.526 -20.675 31.583  1.00 10.06 ?  277  GLN B CA  1 
ATOM   3741 C C   . GLN C 1 54  ? -18.561 -21.766 32.059  1.00 9.24  ?  277  GLN B C   1 
ATOM   3742 O O   . GLN C 1 54  ? -17.443 -21.896 31.530  1.00 10.81 ?  277  GLN B O   1 
ATOM   3743 C CB  . GLN C 1 54  ? -20.939 -21.179 31.211  1.00 10.88 ?  277  GLN B CB  1 
ATOM   3744 C CG  . GLN C 1 54  ? -21.036 -21.961 29.906  1.00 10.25 ?  277  GLN B CG  1 
ATOM   3745 C CD  . GLN C 1 54  ? -20.528 -23.364 30.098  1.00 12.97 ?  277  GLN B CD  1 
ATOM   3746 O OE1 . GLN C 1 54  ? -21.074 -24.170 30.890  1.00 11.33 ?  277  GLN B OE1 1 
ATOM   3747 N NE2 . GLN C 1 54  ? -19.436 -23.697 29.381  1.00 8.88  ?  277  GLN B NE2 1 
ATOM   3748 N N   . LEU C 1 55  ? -18.923 -22.505 33.126  1.00 8.47  ?  278  LEU B N   1 
ATOM   3749 C CA  . LEU C 1 55  ? -17.944 -23.331 33.840  1.00 7.74  ?  278  LEU B CA  1 
ATOM   3750 C C   . LEU C 1 55  ? -17.814 -24.762 33.313  1.00 10.29 ?  278  LEU B C   1 
ATOM   3751 O O   . LEU C 1 55  ? -16.736 -25.339 33.492  1.00 12.10 ?  278  LEU B O   1 
ATOM   3752 C CB  . LEU C 1 55  ? -18.303 -23.397 35.338  1.00 10.66 ?  278  LEU B CB  1 
ATOM   3753 C CG  . LEU C 1 55  ? -18.364 -22.065 36.114  1.00 9.59  ?  278  LEU B CG  1 
ATOM   3754 C CD1 . LEU C 1 55  ? -18.986 -22.365 37.512  1.00 10.06 ?  278  LEU B CD1 1 
ATOM   3755 C CD2 . LEU C 1 55  ? -16.973 -21.464 36.224  1.00 11.34 ?  278  LEU B CD2 1 
ATOM   3756 N N   . SER C 1 56  ? -18.851 -25.284 32.630  1.00 12.10 ?  279  SER B N   1 
ATOM   3757 C CA  . SER C 1 56  ? -18.898 -26.694 32.255  1.00 16.14 ?  279  SER B CA  1 
ATOM   3758 C C   . SER C 1 56  ? -18.144 -26.906 30.957  1.00 11.03 ?  279  SER B C   1 
ATOM   3759 O O   . SER C 1 56  ? -18.518 -26.351 29.963  1.00 10.65 ?  279  SER B O   1 
ATOM   3760 C CB  . SER C 1 56  ? -20.334 -27.104 32.029  1.00 16.97 ?  279  SER B CB  1 
ATOM   3761 O OG  . SER C 1 56  ? -20.513 -28.259 31.145  1.00 15.97 ?  279  SER B OG  1 
ATOM   3762 N N   . PRO C 1 57  ? -17.113 -27.715 30.938  1.00 10.07 ?  280  PRO B N   1 
ATOM   3763 C CA  . PRO C 1 57  ? -16.422 -28.033 29.679  1.00 9.75  ?  280  PRO B CA  1 
ATOM   3764 C C   . PRO C 1 57  ? -17.311 -28.729 28.645  1.00 11.07 ?  280  PRO B C   1 
ATOM   3765 O O   . PRO C 1 57  ? -17.189 -28.521 27.412  1.00 11.39 ?  280  PRO B O   1 
ATOM   3766 C CB  . PRO C 1 57  ? -15.297 -28.972 30.200  1.00 13.24 ?  280  PRO B CB  1 
ATOM   3767 C CG  . PRO C 1 57  ? -15.293 -28.701 31.704  1.00 14.04 ?  280  PRO B CG  1 
ATOM   3768 C CD  . PRO C 1 57  ? -16.621 -28.489 32.104  1.00 15.20 ?  280  PRO B CD  1 
ATOM   3769 N N   . VAL C 1 58  ? -18.280 -29.507 29.114  1.00 8.45  ?  281  VAL B N   1 
ATOM   3770 C CA  . VAL C 1 58  ? -19.022 -30.320 28.166  1.00 8.45  ?  281  VAL B CA  1 
ATOM   3771 C C   . VAL C 1 58  ? -20.161 -29.544 27.544  1.00 12.09 ?  281  VAL B C   1 
ATOM   3772 O O   . VAL C 1 58  ? -20.708 -30.012 26.531  1.00 16.66 ?  281  VAL B O   1 
ATOM   3773 C CB  . VAL C 1 58  ? -19.537 -31.619 28.825  1.00 9.61  ?  281  VAL B CB  1 
ATOM   3774 C CG1 . VAL C 1 58  ? -18.347 -32.436 29.360  1.00 11.04 ?  281  VAL B CG1 1 
ATOM   3775 C CG2 . VAL C 1 58  ? -20.550 -31.300 29.956  1.00 12.66 ?  281  VAL B CG2 1 
ATOM   3776 N N   . ASN C 1 59  ? -20.493 -28.340 28.049  1.00 9.36  ?  282  ASN B N   1 
ATOM   3777 C CA  . ASN C 1 59  ? -21.603 -27.578 27.480  1.00 11.05 ?  282  ASN B CA  1 
ATOM   3778 C C   . ASN C 1 59  ? -21.196 -26.639 26.344  1.00 13.19 ?  282  ASN B C   1 
ATOM   3779 O O   . ASN C 1 59  ? -22.055 -26.046 25.691  1.00 18.28 ?  282  ASN B O   1 
ATOM   3780 C CB  . ASN C 1 59  ? -22.329 -26.748 28.535  1.00 12.23 ?  282  ASN B CB  1 
ATOM   3781 C CG  . ASN C 1 59  ? -22.709 -27.562 29.712  1.00 24.22 ?  282  ASN B CG  1 
ATOM   3782 O OD1 . ASN C 1 59  ? -23.501 -28.484 29.560  1.00 23.35 ?  282  ASN B OD1 1 
ATOM   3783 N ND2 . ASN C 1 59  ? -22.443 -27.032 30.901  1.00 26.70 ?  282  ASN B ND2 1 
ATOM   3784 N N   . ILE C 1 60  ? -19.925 -26.569 26.020  1.00 8.05  ?  283  ILE B N   1 
ATOM   3785 C CA  . ILE C 1 60  ? -19.462 -25.632 25.020  1.00 6.91  ?  283  ILE B CA  1 
ATOM   3786 C C   . ILE C 1 60  ? -19.867 -26.173 23.653  1.00 9.40  ?  283  ILE B C   1 
ATOM   3787 O O   . ILE C 1 60  ? -19.613 -27.346 23.339  1.00 7.09  ?  283  ILE B O   1 
ATOM   3788 C CB  . ILE C 1 60  ? -17.935 -25.513 25.134  1.00 7.58  ?  283  ILE B CB  1 
ATOM   3789 C CG1 . ILE C 1 60  ? -17.523 -24.964 26.519  1.00 8.47  ?  283  ILE B CG1 1 
ATOM   3790 C CG2 . ILE C 1 60  ? -17.346 -24.614 24.004  1.00 8.37  ?  283  ILE B CG2 1 
ATOM   3791 C CD1 . ILE C 1 60  ? -15.980 -25.132 26.805  1.00 9.53  ?  283  ILE B CD1 1 
ATOM   3792 N N   . CYS C 1 61  ? -20.509 -25.331 22.842  1.00 8.01  ?  284  CYS B N   1 
ATOM   3793 C CA  . CYS C 1 61  ? -21.004 -25.658 21.492  1.00 7.94  ?  284  CYS B CA  1 
ATOM   3794 C C   . CYS C 1 61  ? -22.103 -26.716 21.507  1.00 8.68  ?  284  CYS B C   1 
ATOM   3795 O O   . CYS C 1 61  ? -22.368 -27.365 20.479  1.00 8.25  ?  284  CYS B O   1 
ATOM   3796 C CB  . CYS C 1 61  ? -19.860 -26.099 20.528  1.00 7.47  ?  284  CYS B CB  1 
ATOM   3797 S SG  . CYS C 1 61  ? -18.711 -24.730 20.091  1.00 8.71  ?  284  CYS B SG  1 
ATOM   3798 N N   . THR C 1 62  ? -22.837 -26.830 22.632  1.00 8.29  ?  285  THR B N   1 
ATOM   3799 C CA  . THR C 1 62  ? -24.051 -27.664 22.701  1.00 7.84  ?  285  THR B CA  1 
ATOM   3800 C C   . THR C 1 62  ? -25.272 -26.736 22.602  1.00 9.23  ?  285  THR B C   1 
ATOM   3801 O O   . THR C 1 62  ? -25.186 -25.548 22.916  1.00 12.17 ?  285  THR B O   1 
ATOM   3802 C CB  . THR C 1 62  ? -24.147 -28.456 24.014  1.00 11.78 ?  285  THR B CB  1 
ATOM   3803 O OG1 . THR C 1 62  ? -24.230 -27.522 25.118  1.00 18.71 ?  285  THR B OG1 1 
ATOM   3804 C CG2 . THR C 1 62  ? -22.945 -29.435 24.123  1.00 9.09  ?  285  THR B CG2 1 
ATOM   3805 N N   . PHE C 1 63  ? -26.388 -27.283 22.135  1.00 9.08  ?  286  PHE B N   1 
ATOM   3806 C CA  . PHE C 1 63  ? -27.670 -26.565 22.106  1.00 8.11  ?  286  PHE B CA  1 
ATOM   3807 C C   . PHE C 1 63  ? -28.781 -27.503 22.558  1.00 9.25  ?  286  PHE B C   1 
ATOM   3808 O O   . PHE C 1 63  ? -28.710 -28.714 22.343  1.00 9.50  ?  286  PHE B O   1 
ATOM   3809 C CB  . PHE C 1 63  ? -28.047 -26.064 20.692  1.00 6.90  ?  286  PHE B CB  1 
ATOM   3810 C CG  . PHE C 1 63  ? -27.012 -25.259 20.010  1.00 8.60  ?  286  PHE B CG  1 
ATOM   3811 C CD1 . PHE C 1 63  ? -26.028 -25.897 19.215  1.00 9.89  ?  286  PHE B CD1 1 
ATOM   3812 C CD2 . PHE C 1 63  ? -27.002 -23.876 20.110  1.00 9.13  ?  286  PHE B CD2 1 
ATOM   3813 C CE1 . PHE C 1 63  ? -25.063 -25.127 18.525  1.00 10.61 ?  286  PHE B CE1 1 
ATOM   3814 C CE2 . PHE C 1 63  ? -25.998 -23.091 19.412  1.00 10.78 ?  286  PHE B CE2 1 
ATOM   3815 C CZ  . PHE C 1 63  ? -25.078 -23.714 18.641  1.00 10.98 ?  286  PHE B CZ  1 
ATOM   3816 N N   . ARG C 1 64  ? -29.828 -26.934 23.178  1.00 7.54  ?  287  ARG B N   1 
ATOM   3817 C CA  . ARG C 1 64  ? -30.989 -27.712 23.594  1.00 8.82  ?  287  ARG B CA  1 
ATOM   3818 C C   . ARG C 1 64  ? -32.234 -26.887 23.336  1.00 10.04 ?  287  ARG B C   1 
ATOM   3819 O O   . ARG C 1 64  ? -32.214 -25.652 23.461  1.00 10.70 ?  287  ARG B O   1 
ATOM   3820 C CB  . ARG C 1 64  ? -30.964 -28.039 25.122  1.00 14.34 ?  287  ARG B CB  1 
ATOM   3821 C CG  . ARG C 1 64  ? -29.815 -28.891 25.610  1.00 16.40 ?  287  ARG B CG  1 
ATOM   3822 C CD  . ARG C 1 64  ? -29.759 -28.839 27.184  1.00 19.10 ?  287  ARG B CD  1 
ATOM   3823 N NE  . ARG C 1 64  ? -28.897 -29.889 27.729  1.00 20.24 ?  287  ARG B NE  1 
ATOM   3824 C CZ  . ARG C 1 64  ? -27.574 -29.811 27.799  1.00 22.00 ?  287  ARG B CZ  1 
ATOM   3825 N NH1 . ARG C 1 64  ? -26.926 -28.694 27.475  1.00 23.20 ?  287  ARG B NH1 1 
ATOM   3826 N NH2 . ARG C 1 64  ? -26.880 -30.898 28.140  1.00 20.43 ?  287  ARG B NH2 1 
ATOM   3827 N N   . GLY C 1 65  ? -33.318 -27.586 23.039  1.00 8.68  ?  288  GLY B N   1 
ATOM   3828 C CA  . GLY C 1 65  ? -34.592 -26.890 22.863  1.00 11.04 ?  288  GLY B CA  1 
ATOM   3829 C C   . GLY C 1 65  ? -35.594 -27.808 22.200  1.00 10.58 ?  288  GLY B C   1 
ATOM   3830 O O   . GLY C 1 65  ? -35.447 -29.029 22.243  1.00 11.96 ?  288  GLY B O   1 
ATOM   3831 N N   . ASP C 1 66  ? -36.640 -27.225 21.613  1.00 10.28 ?  289  ASP B N   1 
ATOM   3832 C CA  . ASP C 1 66  ? -37.572 -27.985 20.775  1.00 9.28  ?  289  ASP B CA  1 
ATOM   3833 C C   . ASP C 1 66  ? -37.338 -27.607 19.319  1.00 10.29 ?  289  ASP B C   1 
ATOM   3834 O O   . ASP C 1 66  ? -36.780 -26.536 19.029  1.00 9.78  ?  289  ASP B O   1 
ATOM   3835 C CB  . ASP C 1 66  ? -39.054 -27.699 21.156  1.00 10.14 ?  289  ASP B CB  1 
ATOM   3836 C CG  . ASP C 1 66  ? -39.430 -26.250 20.933  1.00 15.91 ?  289  ASP B CG  1 
ATOM   3837 O OD1 . ASP C 1 66  ? -38.997 -25.347 21.706  1.00 20.15 -1 289  ASP B OD1 1 
ATOM   3838 O OD2 . ASP C 1 66  ? -40.118 -25.973 19.943  1.00 17.51 ?  289  ASP B OD2 1 
ATOM   3839 N N   . VAL C 1 67  ? -37.704 -28.503 18.408  1.00 9.51  ?  290  VAL B N   1 
ATOM   3840 C CA  . VAL C 1 67  ? -37.453 -28.236 16.983  1.00 8.43  ?  290  VAL B CA  1 
ATOM   3841 C C   . VAL C 1 67  ? -38.738 -28.230 16.168  1.00 11.33 ?  290  VAL B C   1 
ATOM   3842 O O   . VAL C 1 67  ? -39.731 -28.878 16.513  1.00 12.53 ?  290  VAL B O   1 
ATOM   3843 C CB  . VAL C 1 67  ? -36.479 -29.260 16.367  1.00 8.33  ?  290  VAL B CB  1 
ATOM   3844 C CG1 . VAL C 1 67  ? -35.105 -29.080 16.959  1.00 10.81 ?  290  VAL B CG1 1 
ATOM   3845 C CG2 . VAL C 1 67  ? -36.931 -30.717 16.601  1.00 8.47  ?  290  VAL B CG2 1 
ATOM   3846 N N   . THR C 1 68  ? -38.674 -27.526 15.041  1.00 11.11 ?  291  THR B N   1 
ATOM   3847 C CA  . THR C 1 68  ? -39.741 -27.534 14.029  1.00 11.84 ?  291  THR B CA  1 
ATOM   3848 C C   . THR C 1 68  ? -39.103 -27.564 12.646  1.00 11.97 ?  291  THR B C   1 
ATOM   3849 O O   . THR C 1 68  ? -37.925 -27.226 12.471  1.00 9.79  ?  291  THR B O   1 
ATOM   3850 C CB  . THR C 1 68  ? -40.632 -26.284 14.139  1.00 16.76 ?  291  THR B CB  1 
ATOM   3851 O OG1 . THR C 1 68  ? -39.835 -25.095 13.960  1.00 17.72 ?  291  THR B OG1 1 
ATOM   3852 C CG2 . THR C 1 68  ? -41.310 -26.246 15.493  1.00 18.71 ?  291  THR B CG2 1 
ATOM   3853 N N   . HIS C 1 69  ? -39.908 -27.869 11.631  1.00 11.83 ?  292  HIS B N   1 
ATOM   3854 C CA  . HIS C 1 69  ? -39.405 -27.683 10.268  1.00 10.49 ?  292  HIS B CA  1 
ATOM   3855 C C   . HIS C 1 69  ? -40.579 -27.487 9.328   1.00 12.88 ?  292  HIS B C   1 
ATOM   3856 O O   . HIS C 1 69  ? -41.744 -27.759 9.676   1.00 12.73 ?  292  HIS B O   1 
ATOM   3857 C CB  . HIS C 1 69  ? -38.532 -28.878 9.812   1.00 10.38 ?  292  HIS B CB  1 
ATOM   3858 C CG  . HIS C 1 69  ? -39.298 -30.123 9.482   1.00 10.61 ?  292  HIS B CG  1 
ATOM   3859 N ND1 . HIS C 1 69  ? -38.911 -30.990 8.488   1.00 10.33 ?  292  HIS B ND1 1 
ATOM   3860 C CD2 . HIS C 1 69  ? -40.419 -30.654 10.020  1.00 12.01 ?  292  HIS B CD2 1 
ATOM   3861 C CE1 . HIS C 1 69  ? -39.748 -32.017 8.432   1.00 11.39 ?  292  HIS B CE1 1 
ATOM   3862 N NE2 . HIS C 1 69  ? -40.681 -31.832 9.352   1.00 11.90 ?  292  HIS B NE2 1 
ATOM   3863 N N   . ILE C 1 70  ? -40.241 -27.027 8.137   1.00 11.07 ?  293  ILE B N   1 
ATOM   3864 C CA  . ILE C 1 70  ? -41.172 -26.970 7.011   1.00 11.58 ?  293  ILE B CA  1 
ATOM   3865 C C   . ILE C 1 70  ? -41.317 -28.371 6.447   1.00 11.93 ?  293  ILE B C   1 
ATOM   3866 O O   . ILE C 1 70  ? -40.331 -29.102 6.314   1.00 10.76 ?  293  ILE B O   1 
ATOM   3867 C CB  . ILE C 1 70  ? -40.648 -26.000 5.928   1.00 16.47 ?  293  ILE B CB  1 
ATOM   3868 C CG1 . ILE C 1 70  ? -40.496 -24.609 6.514   1.00 19.32 ?  293  ILE B CG1 1 
ATOM   3869 C CG2 . ILE C 1 70  ? -41.618 -26.035 4.702   1.00 16.41 ?  293  ILE B CG2 1 
ATOM   3870 C CD1 . ILE C 1 70  ? -41.797 -23.956 6.771   1.00 24.55 ?  293  ILE B CD1 1 
ATOM   3871 N N   . THR C 1 71  ? -42.558 -28.781 6.110   1.00 9.55  ?  294  THR B N   1 
ATOM   3872 C CA  . THR C 1 71  ? -42.725 -30.119 5.558   1.00 8.29  ?  294  THR B CA  1 
ATOM   3873 C C   . THR C 1 71  ? -41.819 -30.328 4.356   1.00 11.16 ?  294  THR B C   1 
ATOM   3874 O O   . THR C 1 71  ? -41.679 -29.452 3.489   1.00 13.18 ?  294  THR B O   1 
ATOM   3875 C CB  . THR C 1 71  ? -44.211 -30.322 5.185   1.00 12.57 ?  294  THR B CB  1 
ATOM   3876 O OG1 . THR C 1 71  ? -44.966 -30.345 6.423   1.00 13.68 ?  294  THR B OG1 1 
ATOM   3877 C CG2 . THR C 1 71  ? -44.418 -31.663 4.427   1.00 11.61 ?  294  THR B CG2 1 
ATOM   3878 N N   . GLY C 1 72  ? -41.138 -31.481 4.337   1.00 10.62 ?  295  GLY B N   1 
ATOM   3879 C CA  . GLY C 1 72  ? -40.263 -31.823 3.214   1.00 13.73 ?  295  GLY B CA  1 
ATOM   3880 C C   . GLY C 1 72  ? -38.828 -31.377 3.397   1.00 12.21 ?  295  GLY B C   1 
ATOM   3881 O O   . GLY C 1 72  ? -37.971 -31.757 2.575   1.00 14.58 ?  295  GLY B O   1 
ATOM   3882 N N   . SER C 1 73  ? -38.556 -30.549 4.403   1.00 9.21  ?  296  SER B N   1 
ATOM   3883 C CA  . SER C 1 73  ? -37.207 -29.988 4.588   1.00 10.15 ?  296  SER B CA  1 
ATOM   3884 C C   . SER C 1 73  ? -36.414 -30.855 5.557   1.00 11.91 ?  296  SER B C   1 
ATOM   3885 O O   . SER C 1 73  ? -36.934 -31.283 6.591   1.00 11.39 ?  296  SER B O   1 
ATOM   3886 C CB  . SER C 1 73  ? -37.285 -28.558 5.128   1.00 12.21 ?  296  SER B CB  1 
ATOM   3887 O OG  . SER C 1 73  ? -35.937 -28.048 5.340   1.00 11.53 ?  296  SER B OG  1 
ATOM   3888 N N   . ARG C 1 74  ? -35.117 -31.061 5.240   1.00 9.57  ?  297  ARG B N   1 
ATOM   3889 C CA  . ARG C 1 74  ? -34.209 -31.697 6.199   1.00 11.01 ?  297  ARG B CA  1 
ATOM   3890 C C   . ARG C 1 74  ? -33.563 -30.691 7.136   1.00 9.31  ?  297  ARG B C   1 
ATOM   3891 O O   . ARG C 1 74  ? -32.768 -31.105 7.992   1.00 8.57  ?  297  ARG B O   1 
ATOM   3892 C CB  . ARG C 1 74  ? -33.099 -32.500 5.472   1.00 10.27 ?  297  ARG B CB  1 
ATOM   3893 C CG  . ARG C 1 74  ? -33.619 -33.559 4.526   1.00 13.43 ?  297  ARG B CG  1 
ATOM   3894 C CD  . ARG C 1 74  ? -32.472 -34.367 3.913   1.00 17.71 ?  297  ARG B CD  1 
ATOM   3895 N NE  . ARG C 1 74  ? -32.996 -35.586 3.312   1.00 32.54 ?  297  ARG B NE  1 
ATOM   3896 C CZ  . ARG C 1 74  ? -32.304 -36.715 3.216   1.00 41.57 ?  297  ARG B CZ  1 
ATOM   3897 N NH1 . ARG C 1 74  ? -31.040 -36.784 3.613   1.00 38.39 ?  297  ARG B NH1 1 
ATOM   3898 N NH2 . ARG C 1 74  ? -32.892 -37.797 2.703   1.00 46.69 ?  297  ARG B NH2 1 
ATOM   3899 N N   . ASN C 1 75  ? -33.952 -29.413 7.063   1.00 7.13  ?  298  ASN B N   1 
ATOM   3900 C CA  . ASN C 1 75  ? -33.416 -28.398 7.959   1.00 9.47  ?  298  ASN B CA  1 
ATOM   3901 C C   . ASN C 1 75  ? -34.415 -28.128 9.078   1.00 11.58 ?  298  ASN B C   1 
ATOM   3902 O O   . ASN C 1 75  ? -35.612 -27.906 8.820   1.00 12.86 ?  298  ASN B O   1 
ATOM   3903 C CB  . ASN C 1 75  ? -33.126 -27.139 7.169   1.00 9.97  ?  298  ASN B CB  1 
ATOM   3904 C CG  . ASN C 1 75  ? -32.052 -27.345 6.126   1.00 18.98 ?  298  ASN B CG  1 
ATOM   3905 O OD1 . ASN C 1 75  ? -31.095 -28.033 6.382   1.00 20.76 ?  298  ASN B OD1 1 
ATOM   3906 N ND2 . ASN C 1 75  ? -32.185 -26.704 4.953   1.00 20.80 ?  298  ASN B ND2 1 
ATOM   3907 N N   . TYR C 1 76  ? -33.937 -28.153 10.322  1.00 9.25  ?  299  TYR B N   1 
ATOM   3908 C CA  . TYR C 1 76  ? -34.815 -27.979 11.477  1.00 8.64  ?  299  TYR B CA  1 
ATOM   3909 C C   . TYR C 1 76  ? -34.417 -26.725 12.238  1.00 9.57  ?  299  TYR B C   1 
ATOM   3910 O O   . TYR C 1 76  ? -33.239 -26.499 12.487  1.00 10.67 ?  299  TYR B O   1 
ATOM   3911 C CB  . TYR C 1 76  ? -34.772 -29.206 12.434  1.00 8.32  ?  299  TYR B CB  1 
ATOM   3912 C CG  . TYR C 1 76  ? -35.484 -30.406 11.863  1.00 8.06  ?  299  TYR B CG  1 
ATOM   3913 C CD1 . TYR C 1 76  ? -34.873 -31.198 10.888  1.00 9.28  ?  299  TYR B CD1 1 
ATOM   3914 C CD2 . TYR C 1 76  ? -36.743 -30.774 12.318  1.00 9.04  ?  299  TYR B CD2 1 
ATOM   3915 C CE1 . TYR C 1 76  ? -35.514 -32.311 10.337  1.00 8.14  ?  299  TYR B CE1 1 
ATOM   3916 C CE2 . TYR C 1 76  ? -37.398 -31.834 11.777  1.00 8.61  ?  299  TYR B CE2 1 
ATOM   3917 C CZ  . TYR C 1 76  ? -36.801 -32.628 10.813  1.00 9.19  ?  299  TYR B CZ  1 
ATOM   3918 O OH  . TYR C 1 76  ? -37.440 -33.753 10.270  1.00 9.21  ?  299  TYR B OH  1 
ATOM   3919 N N   . THR C 1 77  ? -35.410 -25.928 12.651  1.00 9.05  ?  300  THR B N   1 
ATOM   3920 C CA  . THR C 1 77  ? -35.163 -24.766 13.508  1.00 8.14  ?  300  THR B CA  1 
ATOM   3921 C C   . THR C 1 77  ? -35.275 -25.210 14.958  1.00 9.07  ?  300  THR B C   1 
ATOM   3922 O O   . THR C 1 77  ? -36.252 -25.877 15.316  1.00 11.08 ?  300  THR B O   1 
ATOM   3923 C CB  . THR C 1 77  ? -36.178 -23.650 13.250  1.00 12.46 ?  300  THR B CB  1 
ATOM   3924 O OG1 . THR C 1 77  ? -35.954 -23.128 11.939  1.00 13.48 ?  300  THR B OG1 1 
ATOM   3925 C CG2 . THR C 1 77  ? -35.987 -22.536 14.223  1.00 14.59 ?  300  THR B CG2 1 
ATOM   3926 N N   . MET C 1 78  ? -34.272 -24.890 15.773  1.00 8.98  ?  301  MET B N   1 
ATOM   3927 C CA  . MET C 1 78  ? -34.371 -25.135 17.204  1.00 10.13 ?  301  MET B CA  1 
ATOM   3928 C C   . MET C 1 78  ? -34.694 -23.835 17.945  1.00 12.10 ?  301  MET B C   1 
ATOM   3929 O O   . MET C 1 78  ? -34.010 -22.824 17.762  1.00 11.15 ?  301  MET B O   1 
ATOM   3930 C CB  . MET C 1 78  ? -33.074 -25.754 17.744  1.00 10.27 ?  301  MET B CB  1 
ATOM   3931 C CG  . MET C 1 78  ? -33.155 -26.015 19.267  1.00 9.49  ?  301  MET B CG  1 
ATOM   3932 S SD  . MET C 1 78  ? -31.634 -26.755 19.921  1.00 9.32  ?  301  MET B SD  1 
ATOM   3933 C CE  . MET C 1 78  ? -31.778 -28.482 19.514  1.00 10.89 ?  301  MET B CE  1 
ATOM   3934 N N   . ASN C 1 79  ? -35.771 -23.862 18.736  1.00 12.04 ?  302  ASN B N   1 
ATOM   3935 C CA  . ASN C 1 79  ? -36.089 -22.793 19.677  1.00 13.87 ?  302  ASN B CA  1 
ATOM   3936 C C   . ASN C 1 79  ? -35.326 -23.068 20.959  1.00 10.74 ?  302  ASN B C   1 
ATOM   3937 O O   . ASN C 1 79  ? -35.640 -24.018 21.689  1.00 11.99 ?  302  ASN B O   1 
ATOM   3938 C CB  . ASN C 1 79  ? -37.597 -22.759 19.906  1.00 14.10 ?  302  ASN B CB  1 
ATOM   3939 C CG  . ASN C 1 79  ? -38.352 -22.570 18.603  1.00 16.97 ?  302  ASN B CG  1 
ATOM   3940 O OD1 . ASN C 1 79  ? -38.108 -21.598 17.884  1.00 18.64 ?  302  ASN B OD1 1 
ATOM   3941 N ND2 . ASN C 1 79  ? -39.250 -23.495 18.283  1.00 20.84 ?  302  ASN B ND2 1 
ATOM   3942 N N   . LEU C 1 80  ? -34.277 -22.282 21.194  1.00 10.49 ?  303  LEU B N   1 
ATOM   3943 C CA  . LEU C 1 80  ? -33.350 -22.596 22.277  1.00 11.19 ?  303  LEU B CA  1 
ATOM   3944 C C   . LEU C 1 80  ? -33.996 -22.480 23.649  1.00 15.41 ?  303  LEU B C   1 
ATOM   3945 O O   . LEU C 1 80  ? -34.752 -21.531 23.931  1.00 15.92 ?  303  LEU B O   1 
ATOM   3946 C CB  . LEU C 1 80  ? -32.160 -21.661 22.253  1.00 13.15 ?  303  LEU B CB  1 
ATOM   3947 C CG  . LEU C 1 80  ? -31.280 -21.789 21.017  1.00 12.32 ?  303  LEU B CG  1 
ATOM   3948 C CD1 . LEU C 1 80  ? -30.085 -20.789 21.126  1.00 11.36 ?  303  LEU B CD1 1 
ATOM   3949 C CD2 . LEU C 1 80  ? -30.742 -23.251 20.813  1.00 11.65 ?  303  LEU B CD2 1 
ATOM   3950 N N   . ALA C 1 81  ? -33.690 -23.453 24.491  1.00 13.55 ?  304  ALA B N   1 
ATOM   3951 C CA  . ALA C 1 81  ? -33.924 -23.399 25.930  1.00 15.43 ?  304  ALA B CA  1 
ATOM   3952 C C   . ALA C 1 81  ? -32.600 -23.181 26.648  1.00 18.28 ?  304  ALA B C   1 
ATOM   3953 O O   . ALA C 1 81  ? -31.515 -23.277 26.061  1.00 16.98 ?  304  ALA B O   1 
ATOM   3954 C CB  . ALA C 1 81  ? -34.612 -24.682 26.413  1.00 13.92 ?  304  ALA B CB  1 
ATOM   3955 N N   . SER C 1 82  ? -32.694 -22.852 27.938  1.00 17.93 ?  305  SER B N   1 
ATOM   3956 C CA  . SER C 1 82  ? -31.515 -22.852 28.803  1.00 19.49 ?  305  SER B CA  1 
ATOM   3957 C C   . SER C 1 82  ? -31.011 -24.273 29.030  1.00 17.15 ?  305  SER B C   1 
ATOM   3958 O O   . SER C 1 82  ? -31.706 -25.251 28.746  1.00 17.51 ?  305  SER B O   1 
ATOM   3959 C CB  . SER C 1 82  ? -31.860 -22.243 30.160  1.00 24.17 ?  305  SER B CB  1 
ATOM   3960 O OG  . SER C 1 82  ? -31.900 -20.844 30.048  1.00 30.98 ?  305  SER B OG  1 
ATOM   3961 N N   . GLN C 1 83  ? -29.795 -24.377 29.601  1.00 22.27 ?  306  GLN B N   1 
ATOM   3962 C CA  . GLN C 1 83  ? -29.183 -25.690 29.849  1.00 24.70 ?  306  GLN B CA  1 
ATOM   3963 C C   . GLN C 1 83  ? -30.041 -26.602 30.710  1.00 24.94 ?  306  GLN B C   1 
ATOM   3964 O O   . GLN C 1 83  ? -29.997 -27.828 30.538  1.00 25.41 ?  306  GLN B O   1 
ATOM   3965 C CB  . GLN C 1 83  ? -27.818 -25.570 30.529  1.00 26.87 ?  306  GLN B CB  1 
ATOM   3966 C CG  . GLN C 1 83  ? -27.193 -27.004 30.857  1.00 30.17 ?  306  GLN B CG  1 
ATOM   3967 C CD  . GLN C 1 83  ? -26.285 -27.005 32.112  1.00 29.62 ?  306  GLN B CD  1 
ATOM   3968 O OE1 . GLN C 1 83  ? -25.166 -26.476 32.057  1.00 32.32 ?  306  GLN B OE1 1 
ATOM   3969 N NE2 . GLN C 1 83  ? -26.781 -27.573 33.260  1.00 32.98 ?  306  GLN B NE2 1 
ATOM   3970 N N   . ASN C 1 84  ? -30.789 -26.042 31.662  1.00 23.89 ?  307  ASN B N   1 
ATOM   3971 C CA  . ASN C 1 84  ? -31.633 -26.826 32.544  1.00 25.97 ?  307  ASN B CA  1 
ATOM   3972 C C   . ASN C 1 84  ? -33.066 -26.918 32.042  1.00 26.50 ?  307  ASN B C   1 
ATOM   3973 O O   . ASN C 1 84  ? -33.953 -27.300 32.808  1.00 26.12 ?  307  ASN B O   1 
ATOM   3974 C CB  . ASN C 1 84  ? -31.596 -26.224 33.962  1.00 24.48 ?  307  ASN B CB  1 
ATOM   3975 C CG  . ASN C 1 84  ? -32.097 -24.769 33.996  1.00 26.34 ?  307  ASN B CG  1 
ATOM   3976 O OD1 . ASN C 1 84  ? -32.714 -24.280 33.032  1.00 24.79 ?  307  ASN B OD1 1 
ATOM   3977 N ND2 . ASN C 1 84  ? -31.820 -24.075 35.093  1.00 24.38 ?  307  ASN B ND2 1 
ATOM   3978 N N   . TRP C 1 85  ? -33.310 -26.572 30.774  1.00 21.41 ?  308  TRP B N   1 
ATOM   3979 C CA  . TRP C 1 85  ? -34.576 -26.661 30.063  1.00 20.60 ?  308  TRP B CA  1 
ATOM   3980 C C   . TRP C 1 85  ? -35.529 -25.554 30.481  1.00 25.77 ?  308  TRP B C   1 
ATOM   3981 O O   . TRP C 1 85  ? -36.661 -25.548 30.001  1.00 27.56 ?  308  TRP B O   1 
ATOM   3982 C CB  . TRP C 1 85  ? -35.259 -28.028 30.220  1.00 22.51 ?  308  TRP B CB  1 
ATOM   3983 C CG  . TRP C 1 85  ? -34.401 -29.122 29.643  1.00 25.15 ?  308  TRP B CG  1 
ATOM   3984 C CD1 . TRP C 1 85  ? -33.595 -29.999 30.334  1.00 26.00 ?  308  TRP B CD1 1 
ATOM   3985 C CD2 . TRP C 1 85  ? -34.247 -29.449 28.248  1.00 22.47 ?  308  TRP B CD2 1 
ATOM   3986 N NE1 . TRP C 1 85  ? -32.928 -30.834 29.446  1.00 26.18 ?  308  TRP B NE1 1 
ATOM   3987 C CE2 . TRP C 1 85  ? -33.314 -30.518 28.164  1.00 22.51 ?  308  TRP B CE2 1 
ATOM   3988 C CE3 . TRP C 1 85  ? -34.804 -28.940 27.065  1.00 21.30 ?  308  TRP B CE3 1 
ATOM   3989 C CZ2 . TRP C 1 85  ? -32.943 -31.100 26.935  1.00 20.80 ?  308  TRP B CZ2 1 
ATOM   3990 C CZ3 . TRP C 1 85  ? -34.401 -29.500 25.845  1.00 18.13 ?  308  TRP B CZ3 1 
ATOM   3991 C CH2 . TRP C 1 85  ? -33.502 -30.570 25.796  1.00 18.18 ?  308  TRP B CH2 1 
ATOM   3992 N N   . ASN C 1 86  ? -35.114 -24.615 31.327  1.00 24.31 ?  309  ASN B N   1 
ATOM   3993 C CA  . ASN C 1 86  ? -35.956 -23.444 31.541  1.00 23.24 ?  309  ASN B CA  1 
ATOM   3994 C C   . ASN C 1 86  ? -35.955 -22.552 30.295  1.00 27.25 ?  309  ASN B C   1 
ATOM   3995 O O   . ASN C 1 86  ? -35.116 -22.672 29.401  1.00 23.79 ?  309  ASN B O   1 
ATOM   3996 C CB  . ASN C 1 86  ? -35.469 -22.639 32.734  1.00 25.53 ?  309  ASN B CB  1 
ATOM   3997 C CG  . ASN C 1 86  ? -35.771 -23.306 34.056  1.00 28.55 ?  309  ASN B CG  1 
ATOM   3998 O OD1 . ASN C 1 86  ? -36.513 -24.308 34.138  1.00 29.62 ?  309  ASN B OD1 1 
ATOM   3999 N ND2 . ASN C 1 86  ? -35.179 -22.774 35.094  1.00 28.88 ?  309  ASN B ND2 1 
ATOM   4000 N N   . ASP C 1 87  ? -36.884 -21.604 30.261  1.00 27.50 ?  310  ASP B N   1 
ATOM   4001 C CA  . ASP C 1 87  ? -36.935 -20.670 29.142  1.00 26.73 ?  310  ASP B CA  1 
ATOM   4002 C C   . ASP C 1 87  ? -35.624 -19.907 28.972  1.00 27.36 ?  310  ASP B C   1 
ATOM   4003 O O   . ASP C 1 87  ? -35.030 -19.422 29.939  1.00 29.51 ?  310  ASP B O   1 
ATOM   4004 C CB  . ASP C 1 87  ? -38.072 -19.655 29.355  1.00 30.02 ?  310  ASP B CB  1 
ATOM   4005 C CG  . ASP C 1 87  ? -39.436 -20.280 29.278  1.00 29.78 ?  310  ASP B CG  1 
ATOM   4006 O OD1 . ASP C 1 87  ? -39.568 -21.442 28.854  1.00 26.67 ?  310  ASP B OD1 1 
ATOM   4007 O OD2 . ASP C 1 87  ? -40.419 -19.586 29.635  1.00 43.07 -1 310  ASP B OD2 1 
ATOM   4008 N N   . TYR C 1 88  ? -35.204 -19.738 27.722  1.00 23.36 ?  311  TYR B N   1 
ATOM   4009 C CA  . TYR C 1 88  ? -34.094 -18.845 27.419  1.00 23.58 ?  311  TYR B CA  1 
ATOM   4010 C C   . TYR C 1 88  ? -34.536 -17.390 27.529  1.00 28.22 ?  311  TYR B C   1 
ATOM   4011 O O   . TYR C 1 88  ? -35.672 -17.053 27.186  1.00 28.89 ?  311  TYR B O   1 
ATOM   4012 C CB  . TYR C 1 88  ? -33.564 -19.106 26.004  1.00 22.11 ?  311  TYR B CB  1 
ATOM   4013 C CG  . TYR C 1 88  ? -32.616 -18.039 25.481  1.00 21.24 ?  311  TYR B CG  1 
ATOM   4014 C CD1 . TYR C 1 88  ? -31.389 -17.789 26.101  1.00 21.34 ?  311  TYR B CD1 1 
ATOM   4015 C CD2 . TYR C 1 88  ? -32.950 -17.265 24.359  1.00 21.08 ?  311  TYR B CD2 1 
ATOM   4016 C CE1 . TYR C 1 88  ? -30.518 -16.807 25.643  1.00 21.64 ?  311  TYR B CE1 1 
ATOM   4017 C CE2 . TYR C 1 88  ? -32.076 -16.282 23.884  1.00 20.46 ?  311  TYR B CE2 1 
ATOM   4018 C CZ  . TYR C 1 88  ? -30.866 -16.061 24.511  1.00 17.94 ?  311  TYR B CZ  1 
ATOM   4019 O OH  . TYR C 1 88  ? -30.002 -15.091 24.076  1.00 20.44 ?  311  TYR B OH  1 
ATOM   4020 N N   . ASP C 1 89  ? -33.624 -16.526 27.978  1.00 25.28 ?  312  ASP B N   1 
ATOM   4021 C CA  . ASP C 1 89  ? -33.902 -15.097 28.171  1.00 23.68 ?  312  ASP B CA  1 
ATOM   4022 C C   . ASP C 1 89  ? -32.989 -14.226 27.312  1.00 27.43 ?  312  ASP B C   1 
ATOM   4023 O O   . ASP C 1 89  ? -31.819 -13.994 27.670  1.00 27.59 ?  312  ASP B O   1 
ATOM   4024 C CB  . ASP C 1 89  ? -33.752 -14.741 29.650  1.00 33.91 ?  312  ASP B CB  1 
ATOM   4025 C CG  . ASP C 1 89  ? -33.930 -13.246 29.923  1.00 32.82 ?  312  ASP B CG  1 
ATOM   4026 O OD1 . ASP C 1 89  ? -34.419 -12.527 29.029  1.00 31.72 ?  312  ASP B OD1 1 
ATOM   4027 O OD2 . ASP C 1 89  ? -33.558 -12.797 31.032  1.00 38.61 -1 312  ASP B OD2 1 
ATOM   4028 N N   . PRO C 1 90  ? -33.471 -13.693 26.190  1.00 26.12 ?  313  PRO B N   1 
ATOM   4029 C CA  . PRO C 1 90  ? -32.605 -12.893 25.318  1.00 24.82 ?  313  PRO B CA  1 
ATOM   4030 C C   . PRO C 1 90  ? -32.250 -11.525 25.891  1.00 30.18 ?  313  PRO B C   1 
ATOM   4031 O O   . PRO C 1 90  ? -31.441 -10.818 25.285  1.00 28.98 ?  313  PRO B O   1 
ATOM   4032 C CB  . PRO C 1 90  ? -33.431 -12.747 24.028  1.00 29.42 ?  313  PRO B CB  1 
ATOM   4033 C CG  . PRO C 1 90  ? -34.801 -13.101 24.403  1.00 30.72 ?  313  PRO B CG  1 
ATOM   4034 C CD  . PRO C 1 90  ? -34.821 -13.878 25.646  1.00 26.23 ?  313  PRO B CD  1 
ATOM   4035 N N   . THR C 1 91  ? -32.809 -11.125 27.038  1.00 31.52 ?  314  THR B N   1 
ATOM   4036 C CA  . THR C 1 91  ? -32.509 -9.798  27.575  1.00 31.63 ?  314  THR B CA  1 
ATOM   4037 C C   . THR C 1 91  ? -31.349 -9.788  28.556  1.00 31.26 ?  314  THR B C   1 
ATOM   4038 O O   . THR C 1 91  ? -30.968 -8.700  29.004  1.00 30.73 ?  314  THR B O   1 
ATOM   4039 C CB  . THR C 1 91  ? -33.751 -9.160  28.271  1.00 34.62 ?  314  THR B CB  1 
ATOM   4040 O OG1 . THR C 1 91  ? -34.115 -9.898  29.448  1.00 34.35 ?  314  THR B OG1 1 
ATOM   4041 C CG2 . THR C 1 91  ? -34.938 -9.086  27.327  1.00 33.70 ?  314  THR B CG2 1 
ATOM   4042 N N   . GLU C 1 92  ? -30.778 -10.938 28.928  1.00 28.42 ?  315  GLU B N   1 
ATOM   4043 C CA  . GLU C 1 92  ? -29.591 -10.873 29.771  1.00 28.56 ?  315  GLU B CA  1 
ATOM   4044 C C   . GLU C 1 92  ? -28.458 -10.224 28.992  1.00 24.98 ?  315  GLU B C   1 
ATOM   4045 O O   . GLU C 1 92  ? -28.396 -10.301 27.760  1.00 23.96 ?  315  GLU B O   1 
ATOM   4046 C CB  . GLU C 1 92  ? -29.105 -12.235 30.251  1.00 27.99 ?  315  GLU B CB  1 
ATOM   4047 C CG  . GLU C 1 92  ? -30.105 -13.289 30.396  1.00 36.40 ?  315  GLU B CG  1 
ATOM   4048 C CD  . GLU C 1 92  ? -29.434 -14.655 30.344  1.00 46.75 ?  315  GLU B CD  1 
ATOM   4049 O OE1 . GLU C 1 92  ? -29.704 -15.441 29.374  1.00 42.28 ?  315  GLU B OE1 1 
ATOM   4050 O OE2 . GLU C 1 92  ? -28.636 -14.921 31.291  1.00 45.26 -1 315  GLU B OE2 1 
ATOM   4051 N N   . GLU C 1 93  ? -27.550 -9.607  29.738  1.00 24.17 ?  316  GLU B N   1 
ATOM   4052 C CA  . GLU C 1 93  ? -26.505 -8.751  29.173  1.00 23.29 ?  316  GLU B CA  1 
ATOM   4053 C C   . GLU C 1 93  ? -25.266 -9.583  28.818  1.00 23.04 ?  316  GLU B C   1 
ATOM   4054 O O   . GLU C 1 93  ? -24.162 -9.413  29.345  1.00 19.30 ?  316  GLU B O   1 
ATOM   4055 C CB  . GLU C 1 93  ? -26.188 -7.631  30.156  1.00 27.13 ?  316  GLU B CB  1 
ATOM   4056 C CG  . GLU C 1 93  ? -27.443 -6.818  30.445  1.00 32.04 ?  316  GLU B CG  1 
ATOM   4057 C CD  . GLU C 1 93  ? -27.136 -5.424  30.945  1.00 39.55 ?  316  GLU B CD  1 
ATOM   4058 O OE1 . GLU C 1 93  ? -26.354 -5.328  31.914  1.00 42.85 ?  316  GLU B OE1 1 
ATOM   4059 O OE2 . GLU C 1 93  ? -27.681 -4.445  30.378  1.00 39.37 -1 316  GLU B OE2 1 
ATOM   4060 N N   . ILE C 1 94  ? -25.488 -10.515 27.893  1.00 18.52 ?  317  ILE B N   1 
ATOM   4061 C CA  . ILE C 1 94  ? -24.435 -11.388 27.367  1.00 15.63 ?  317  ILE B CA  1 
ATOM   4062 C C   . ILE C 1 94  ? -24.570 -11.382 25.851  1.00 15.10 ?  317  ILE B C   1 
ATOM   4063 O O   . ILE C 1 94  ? -25.614 -10.995 25.315  1.00 15.85 ?  317  ILE B O   1 
ATOM   4064 C CB  . ILE C 1 94  ? -24.551 -12.828 27.925  1.00 16.60 ?  317  ILE B CB  1 
ATOM   4065 C CG1 . ILE C 1 94  ? -25.953 -13.399 27.620  1.00 16.94 ?  317  ILE B CG1 1 
ATOM   4066 C CG2 . ILE C 1 94  ? -24.355 -12.821 29.408  1.00 20.96 ?  317  ILE B CG2 1 
ATOM   4067 C CD1 . ILE C 1 94  ? -26.203 -14.823 28.131  1.00 19.86 ?  317  ILE B CD1 1 
ATOM   4068 N N   . PRO C 1 95  ? -23.507 -11.742 25.111  1.00 11.51 ?  318  PRO B N   1 
ATOM   4069 C CA  . PRO C 1 95  ? -23.602 -11.692 23.640  1.00 12.66 ?  318  PRO B CA  1 
ATOM   4070 C C   . PRO C 1 95  ? -24.580 -12.696 23.042  1.00 11.15 ?  318  PRO B C   1 
ATOM   4071 O O   . PRO C 1 95  ? -25.032 -12.509 21.903  1.00 12.08 ?  318  PRO B O   1 
ATOM   4072 C CB  . PRO C 1 95  ? -22.153 -11.994 23.186  1.00 12.40 ?  318  PRO B CB  1 
ATOM   4073 C CG  . PRO C 1 95  ? -21.298 -11.557 24.409  1.00 12.52 ?  318  PRO B CG  1 
ATOM   4074 C CD  . PRO C 1 95  ? -22.112 -12.004 25.569  1.00 12.22 ?  318  PRO B CD  1 
ATOM   4075 N N   . ALA C 1 96  ? -24.807 -13.812 23.747  1.00 11.40 ?  319  ALA B N   1 
ATOM   4076 C CA  . ALA C 1 96  ? -25.488 -15.009 23.257  1.00 12.08 ?  319  ALA B CA  1 
ATOM   4077 C C   . ALA C 1 96  ? -25.541 -15.968 24.431  1.00 11.23 ?  319  ALA B C   1 
ATOM   4078 O O   . ALA C 1 96  ? -24.846 -15.733 25.415  1.00 11.37 ?  319  ALA B O   1 
ATOM   4079 C CB  . ALA C 1 96  ? -24.708 -15.627 22.076  1.00 12.07 ?  319  ALA B CB  1 
ATOM   4080 N N   . PRO C 1 97  ? -26.316 -17.059 24.374  1.00 10.92 ?  320  PRO B N   1 
ATOM   4081 C CA  . PRO C 1 97  ? -26.336 -18.005 25.496  1.00 10.35 ?  320  PRO B CA  1 
ATOM   4082 C C   . PRO C 1 97  ? -24.921 -18.438 25.866  1.00 10.91 ?  320  PRO B C   1 
ATOM   4083 O O   . PRO C 1 97  ? -24.046 -18.559 25.001  1.00 11.71 ?  320  PRO B O   1 
ATOM   4084 C CB  . PRO C 1 97  ? -27.141 -19.191 24.945  1.00 13.51 ?  320  PRO B CB  1 
ATOM   4085 C CG  . PRO C 1 97  ? -27.992 -18.579 23.778  1.00 14.29 ?  320  PRO B CG  1 
ATOM   4086 C CD  . PRO C 1 97  ? -27.204 -17.435 23.243  1.00 12.34 ?  320  PRO B CD  1 
ATOM   4087 N N   . LEU C 1 98  ? -24.685 -18.654 27.155  1.00 9.46  ?  321  LEU B N   1 
ATOM   4088 C CA  . LEU C 1 98  ? -23.328 -19.083 27.533  1.00 8.10  ?  321  LEU B CA  1 
ATOM   4089 C C   . LEU C 1 98  ? -22.984 -20.400 26.830  1.00 12.26 ?  321  LEU B C   1 
ATOM   4090 O O   . LEU C 1 98  ? -23.790 -21.332 26.772  1.00 13.25 ?  321  LEU B O   1 
ATOM   4091 C CB  . LEU C 1 98  ? -23.229 -19.260 29.060  1.00 10.12 ?  321  LEU B CB  1 
ATOM   4092 C CG  . LEU C 1 98  ? -23.603 -17.966 29.832  1.00 11.97 ?  321  LEU B CG  1 
ATOM   4093 C CD1 . LEU C 1 98  ? -23.343 -18.172 31.341  1.00 12.86 ?  321  LEU B CD1 1 
ATOM   4094 C CD2 . LEU C 1 98  ? -22.870 -16.761 29.328  1.00 11.82 ?  321  LEU B CD2 1 
ATOM   4095 N N   . GLY C 1 99  ? -21.762 -20.471 26.292  1.00 8.71  ?  322  GLY B N   1 
ATOM   4096 C CA  . GLY C 1 99  ? -21.323 -21.683 25.604  1.00 8.27  ?  322  GLY B CA  1 
ATOM   4097 C C   . GLY C 1 99  ? -21.572 -21.700 24.120  1.00 7.88  ?  322  GLY B C   1 
ATOM   4098 O O   . GLY C 1 99  ? -21.082 -22.625 23.433  1.00 9.34  ?  322  GLY B O   1 
ATOM   4099 N N   . THR C 1 100 ? -22.298 -20.705 23.570  1.00 7.84  ?  323  THR B N   1 
ATOM   4100 C CA  . THR C 1 100 ? -22.536 -20.608 22.123  1.00 7.60  ?  323  THR B CA  1 
ATOM   4101 C C   . THR C 1 100 ? -21.206 -20.628 21.373  1.00 8.08  ?  323  THR B C   1 
ATOM   4102 O O   . THR C 1 100 ? -20.240 -20.010 21.829  1.00 8.06  ?  323  THR B O   1 
ATOM   4103 C CB  . THR C 1 100 ? -23.249 -19.259 21.823  1.00 9.33  ?  323  THR B CB  1 
ATOM   4104 O OG1 . THR C 1 100 ? -24.501 -19.246 22.497  1.00 11.57 ?  323  THR B OG1 1 
ATOM   4105 C CG2 . THR C 1 100 ? -23.435 -18.964 20.306  1.00 8.41  ?  323  THR B CG2 1 
ATOM   4106 N N   . PRO C 1 101 ? -21.111 -21.260 20.207  1.00 8.64  ?  324  PRO B N   1 
ATOM   4107 C CA  . PRO C 1 101 ? -19.869 -21.146 19.418  1.00 6.08  ?  324  PRO B CA  1 
ATOM   4108 C C   . PRO C 1 101 ? -19.453 -19.701 19.186  1.00 6.91  ?  324  PRO B C   1 
ATOM   4109 O O   . PRO C 1 101 ? -20.301 -18.841 18.903  1.00 8.65  ?  324  PRO B O   1 
ATOM   4110 C CB  . PRO C 1 101 ? -20.215 -21.835 18.085  1.00 7.02  ?  324  PRO B CB  1 
ATOM   4111 C CG  . PRO C 1 101 ? -21.407 -22.758 18.412  1.00 8.59  ?  324  PRO B CG  1 
ATOM   4112 C CD  . PRO C 1 101 ? -22.173 -22.015 19.498  1.00 9.79  ?  324  PRO B CD  1 
ATOM   4113 N N   . ASP C 1 102 ? -18.123 -19.436 19.290  1.00 7.08  ?  325  ASP B N   1 
ATOM   4114 C CA  . ASP C 1 102 ? -17.616 -18.074 19.120  1.00 7.14  ?  325  ASP B CA  1 
ATOM   4115 C C   . ASP C 1 102 ? -16.765 -17.942 17.868  1.00 6.95  ?  325  ASP B C   1 
ATOM   4116 O O   . ASP C 1 102 ? -15.861 -17.109 17.802  1.00 8.18  ?  325  ASP B O   1 
ATOM   4117 C CB  . ASP C 1 102 ? -16.856 -17.599 20.369  1.00 7.38  ?  325  ASP B CB  1 
ATOM   4118 C CG  . ASP C 1 102 ? -15.577 -18.389 20.613  1.00 7.72  ?  325  ASP B CG  1 
ATOM   4119 O OD1 . ASP C 1 102 ? -15.296 -19.385 19.882  1.00 7.87  ?  325  ASP B OD1 1 
ATOM   4120 O OD2 . ASP C 1 102 ? -14.847 -18.020 21.574  1.00 6.75  -1 325  ASP B OD2 1 
ATOM   4121 N N   . PHE C 1 103 ? -17.023 -18.760 16.845  1.00 7.24  ?  326  PHE B N   1 
ATOM   4122 C CA  . PHE C 1 103 ? -16.320 -18.631 15.575  1.00 7.69  ?  326  PHE B CA  1 
ATOM   4123 C C   . PHE C 1 103 ? -17.253 -18.975 14.419  1.00 7.78  ?  326  PHE B C   1 
ATOM   4124 O O   . PHE C 1 103 ? -18.262 -19.663 14.604  1.00 8.65  ?  326  PHE B O   1 
ATOM   4125 C CB  . PHE C 1 103 ? -15.059 -19.537 15.477  1.00 7.99  ?  326  PHE B CB  1 
ATOM   4126 C CG  . PHE C 1 103 ? -15.339 -21.005 15.687  1.00 6.64  ?  326  PHE B CG  1 
ATOM   4127 C CD1 . PHE C 1 103 ? -15.339 -21.572 16.971  1.00 9.04  ?  326  PHE B CD1 1 
ATOM   4128 C CD2 . PHE C 1 103 ? -15.587 -21.846 14.594  1.00 9.46  ?  326  PHE B CD2 1 
ATOM   4129 C CE1 . PHE C 1 103 ? -15.588 -22.986 17.150  1.00 9.70  ?  326  PHE B CE1 1 
ATOM   4130 C CE2 . PHE C 1 103 ? -15.868 -23.207 14.785  1.00 8.48  ?  326  PHE B CE2 1 
ATOM   4131 C CZ  . PHE C 1 103 ? -15.851 -23.792 16.066  1.00 9.49  ?  326  PHE B CZ  1 
ATOM   4132 N N   . VAL C 1 104 ? -16.889 -18.493 13.220  1.00 6.88  ?  327  VAL B N   1 
ATOM   4133 C CA  . VAL C 1 104 ? -17.642 -18.770 11.985  1.00 6.64  ?  327  VAL B CA  1 
ATOM   4134 C C   . VAL C 1 104 ? -17.123 -20.068 11.400  1.00 6.54  ?  327  VAL B C   1 
ATOM   4135 O O   . VAL C 1 104 ? -15.925 -20.221 11.080  1.00 8.83  ?  327  VAL B O   1 
ATOM   4136 C CB  . VAL C 1 104 ? -17.495 -17.617 10.973  1.00 9.61  ?  327  VAL B CB  1 
ATOM   4137 C CG1 . VAL C 1 104 ? -17.993 -18.066 9.573   1.00 8.16  ?  327  VAL B CG1 1 
ATOM   4138 C CG2 . VAL C 1 104 ? -18.309 -16.414 11.469  1.00 8.32  ?  327  VAL B CG2 1 
ATOM   4139 N N   . GLY C 1 105 ? -18.044 -21.007 11.208  1.00 7.72  ?  328  GLY B N   1 
ATOM   4140 C CA  . GLY C 1 105 ? -17.671 -22.257 10.563  1.00 6.72  ?  328  GLY B CA  1 
ATOM   4141 C C   . GLY C 1 105 ? -18.849 -23.203 10.675  1.00 6.21  ?  328  GLY B C   1 
ATOM   4142 O O   . GLY C 1 105 ? -19.957 -22.797 11.051  1.00 8.52  ?  328  GLY B O   1 
ATOM   4143 N N   . LYS C 1 106 ? -18.599 -24.452 10.322  1.00 6.15  ?  329  LYS B N   1 
ATOM   4144 C CA  . LYS C 1 106 ? -19.637 -25.487 10.181  1.00 5.73  ?  329  LYS B CA  1 
ATOM   4145 C C   . LYS C 1 106 ? -19.322 -26.558 11.221  1.00 6.29  ?  329  LYS B C   1 
ATOM   4146 O O   . LYS C 1 106 ? -18.307 -27.279 11.087  1.00 6.43  ?  329  LYS B O   1 
ATOM   4147 C CB  . LYS C 1 106 ? -19.639 -26.063 8.758   1.00 5.76  ?  329  LYS B CB  1 
ATOM   4148 C CG  . LYS C 1 106 ? -19.970 -24.981 7.685   1.00 8.12  ?  329  LYS B CG  1 
ATOM   4149 C CD  . LYS C 1 106 ? -19.557 -25.477 6.326   1.00 6.95  ?  329  LYS B CD  1 
ATOM   4150 C CE  . LYS C 1 106 ? -19.773 -24.336 5.324   1.00 7.29  ?  329  LYS B CE  1 
ATOM   4151 N NZ  . LYS C 1 106 ? -19.024 -24.702 4.053   1.00 8.02  ?  329  LYS B NZ  1 
ATOM   4152 N N   . ILE C 1 107 ? -20.153 -26.655 12.264  1.00 6.60  ?  330  ILE B N   1 
ATOM   4153 C CA  . ILE C 1 107 ? -19.931 -27.609 13.348  1.00 5.02  ?  330  ILE B CA  1 
ATOM   4154 C C   . ILE C 1 107 ? -20.880 -28.776 13.129  1.00 6.30  ?  330  ILE B C   1 
ATOM   4155 O O   . ILE C 1 107 ? -22.112 -28.609 13.114  1.00 5.97  ?  330  ILE B O   1 
ATOM   4156 C CB  . ILE C 1 107 ? -20.137 -26.962 14.733  1.00 5.41  ?  330  ILE B CB  1 
ATOM   4157 C CG1 . ILE C 1 107 ? -19.107 -25.833 14.903  1.00 7.77  ?  330  ILE B CG1 1 
ATOM   4158 C CG2 . ILE C 1 107 ? -19.994 -28.045 15.853  1.00 6.56  ?  330  ILE B CG2 1 
ATOM   4159 C CD1 . ILE C 1 107 ? -19.434 -24.998 16.150  1.00 9.07  ?  330  ILE B CD1 1 
ATOM   4160 N N   . GLN C 1 108 ? -20.309 -29.966 12.970  1.00 6.22  ?  331  GLN B N   1 
ATOM   4161 C CA  . GLN C 1 108 ? -21.109 -31.177 12.768  1.00 5.65  ?  331  GLN B CA  1 
ATOM   4162 C C   . GLN C 1 108 ? -21.196 -31.970 14.057  1.00 5.47  ?  331  GLN B C   1 
ATOM   4163 O O   . GLN C 1 108 ? -20.231 -32.038 14.842  1.00 8.73  ?  331  GLN B O   1 
ATOM   4164 C CB  . GLN C 1 108 ? -20.523 -32.046 11.633  1.00 7.12  ?  331  GLN B CB  1 
ATOM   4165 C CG  . GLN C 1 108 ? -21.505 -33.133 11.125  1.00 7.97  ?  331  GLN B CG  1 
ATOM   4166 C CD  . GLN C 1 108 ? -21.089 -33.621 9.735   1.00 10.06 ?  331  GLN B CD  1 
ATOM   4167 O OE1 . GLN C 1 108 ? -20.402 -34.642 9.609   1.00 11.95 ?  331  GLN B OE1 1 
ATOM   4168 N NE2 . GLN C 1 108 ? -21.478 -32.873 8.675   1.00 10.31 ?  331  GLN B NE2 1 
ATOM   4169 N N   . GLY C 1 109 ? -22.355 -32.590 14.264  1.00 7.58  ?  332  GLY B N   1 
ATOM   4170 C CA  . GLY C 1 109 ? -22.508 -33.442 15.437  1.00 5.78  ?  332  GLY B CA  1 
ATOM   4171 C C   . GLY C 1 109 ? -23.812 -34.203 15.304  1.00 6.98  ?  332  GLY B C   1 
ATOM   4172 O O   . GLY C 1 109 ? -24.144 -34.654 14.208  1.00 6.70  ?  332  GLY B O   1 
ATOM   4173 N N   . VAL C 1 110 ? -24.509 -34.421 16.410  1.00 7.02  ?  333  VAL B N   1 
ATOM   4174 C CA  . VAL C 1 110 ? -25.685 -35.288 16.387  1.00 6.61  ?  333  VAL B CA  1 
ATOM   4175 C C   . VAL C 1 110 ? -26.816 -34.601 17.140  1.00 6.80  ?  333  VAL B C   1 
ATOM   4176 O O   . VAL C 1 110 ? -26.629 -34.119 18.265  1.00 6.30  ?  333  VAL B O   1 
ATOM   4177 C CB  . VAL C 1 110 ? -25.387 -36.674 16.995  1.00 8.36  ?  333  VAL B CB  1 
ATOM   4178 C CG1 . VAL C 1 110 ? -26.690 -37.520 16.950  1.00 7.66  ?  333  VAL B CG1 1 
ATOM   4179 C CG2 . VAL C 1 110 ? -24.259 -37.405 16.156  1.00 8.45  ?  333  VAL B CG2 1 
ATOM   4180 N N   . LEU C 1 111 ? -28.003 -34.600 16.527  1.00 8.92  ?  334  LEU B N   1 
ATOM   4181 C CA  . LEU C 1 111 ? -29.224 -34.095 17.148  1.00 7.42  ?  334  LEU B CA  1 
ATOM   4182 C C   . LEU C 1 111 ? -29.979 -35.312 17.696  1.00 7.48  ?  334  LEU B C   1 
ATOM   4183 O O   . LEU C 1 111 ? -30.344 -36.210 16.919  1.00 9.25  ?  334  LEU B O   1 
ATOM   4184 C CB  . LEU C 1 111 ? -30.055 -33.381 16.082  1.00 10.34 ?  334  LEU B CB  1 
ATOM   4185 C CG  . LEU C 1 111 ? -30.930 -32.233 16.501  1.00 13.93 ?  334  LEU B CG  1 
ATOM   4186 C CD1 . LEU C 1 111 ? -30.207 -31.138 17.285  1.00 10.44 ?  334  LEU B CD1 1 
ATOM   4187 C CD2 . LEU C 1 111 ? -31.546 -31.651 15.179  1.00 12.48 ?  334  LEU B CD2 1 
ATOM   4188 N N   . THR C 1 112 ? -30.163 -35.364 19.016  1.00 7.32  ?  335  THR B N   1 
ATOM   4189 C CA  . THR C 1 112 ? -30.875 -36.472 19.683  1.00 7.66  ?  335  THR B CA  1 
ATOM   4190 C C   . THR C 1 112 ? -32.189 -35.963 20.276  1.00 7.82  ?  335  THR B C   1 
ATOM   4191 O O   . THR C 1 112 ? -32.308 -34.775 20.605  1.00 9.25  ?  335  THR B O   1 
ATOM   4192 C CB  . THR C 1 112 ? -30.021 -37.120 20.785  1.00 8.12  ?  335  THR B CB  1 
ATOM   4193 O OG1 . THR C 1 112 ? -29.606 -36.155 21.742  1.00 7.22  ?  335  THR B OG1 1 
ATOM   4194 C CG2 . THR C 1 112 ? -28.791 -37.850 20.195  1.00 7.95  ?  335  THR B CG2 1 
ATOM   4195 N N   . GLN C 1 113 ? -33.175 -36.859 20.414  1.00 8.47  ?  336  GLN B N   1 
ATOM   4196 C CA  . GLN C 1 113 ? -34.470 -36.463 20.975  1.00 9.27  ?  336  GLN B CA  1 
ATOM   4197 C C   . GLN C 1 113 ? -35.102 -37.642 21.716  1.00 7.97  ?  336  GLN B C   1 
ATOM   4198 O O   . GLN C 1 113 ? -34.904 -38.804 21.325  1.00 8.53  ?  336  GLN B O   1 
ATOM   4199 C CB  . GLN C 1 113 ? -35.404 -36.010 19.851  1.00 9.97  ?  336  GLN B CB  1 
ATOM   4200 C CG  . GLN C 1 113 ? -36.733 -35.430 20.287  1.00 10.07 ?  336  GLN B CG  1 
ATOM   4201 C CD  . GLN C 1 113 ? -37.581 -35.098 19.063  1.00 9.27  ?  336  GLN B CD  1 
ATOM   4202 O OE1 . GLN C 1 113 ? -38.214 -35.975 18.456  1.00 9.88  ?  336  GLN B OE1 1 
ATOM   4203 N NE2 . GLN C 1 113 ? -37.601 -33.801 18.711  1.00 9.52  ?  336  GLN B NE2 1 
ATOM   4204 N N   . THR C 1 114 ? -35.802 -37.330 22.807  1.00 7.99  ?  337  THR B N   1 
ATOM   4205 C CA  . THR C 1 114 ? -36.584 -38.327 23.547  1.00 10.39 ?  337  THR B CA  1 
ATOM   4206 C C   . THR C 1 114 ? -38.036 -37.884 23.501  1.00 10.01 ?  337  THR B C   1 
ATOM   4207 O O   . THR C 1 114 ? -38.331 -36.709 23.706  1.00 10.43 ?  337  THR B O   1 
ATOM   4208 C CB  . THR C 1 114 ? -36.122 -38.395 25.014  1.00 12.21 ?  337  THR B CB  1 
ATOM   4209 O OG1 . THR C 1 114 ? -34.748 -38.823 25.066  1.00 9.38  ?  337  THR B OG1 1 
ATOM   4210 C CG2 . THR C 1 114 ? -37.015 -39.410 25.827  1.00 11.60 ?  337  THR B CG2 1 
ATOM   4211 N N   . THR C 1 115 ? -38.936 -38.828 23.261  1.00 9.72  ?  338  THR B N   1 
ATOM   4212 C CA  . THR C 1 115 ? -40.381 -38.594 23.429  1.00 12.17 ?  338  THR B CA  1 
ATOM   4213 C C   . THR C 1 115 ? -40.778 -38.886 24.882  1.00 12.92 ?  338  THR B C   1 
ATOM   4214 O O   . THR C 1 115 ? -40.566 -40.012 25.364  1.00 13.00 ?  338  THR B O   1 
ATOM   4215 C CB  . THR C 1 115 ? -41.144 -39.507 22.480  1.00 13.19 ?  338  THR B CB  1 
ATOM   4216 O OG1 . THR C 1 115 ? -40.747 -39.221 21.131  1.00 11.74 ?  338  THR B OG1 1 
ATOM   4217 C CG2 . THR C 1 115 ? -42.687 -39.358 22.643  1.00 13.68 ?  338  THR B CG2 1 
ATOM   4218 N N   . ARG C 1 116 ? -41.356 -37.887 25.553  1.00 12.76 ?  339  ARG B N   1 
ATOM   4219 C CA  . ARG C 1 116 ? -41.572 -37.965 27.000  1.00 14.50 ?  339  ARG B CA  1 
ATOM   4220 C C   . ARG C 1 116 ? -42.533 -39.099 27.361  1.00 18.26 ?  339  ARG B C   1 
ATOM   4221 O O   . ARG C 1 116 ? -42.315 -39.801 28.358  1.00 16.94 ?  339  ARG B O   1 
ATOM   4222 C CB  . ARG C 1 116 ? -42.097 -36.624 27.521  1.00 19.64 ?  339  ARG B CB  1 
ATOM   4223 C CG  . ARG C 1 116 ? -41.932 -36.355 29.018  1.00 32.24 ?  339  ARG B CG  1 
ATOM   4224 C CD  . ARG C 1 116 ? -42.608 -35.009 29.380  1.00 39.82 ?  339  ARG B CD  1 
ATOM   4225 N NE  . ARG C 1 116 ? -42.509 -34.042 28.279  1.00 54.57 ?  339  ARG B NE  1 
ATOM   4226 C CZ  . ARG C 1 116 ? -41.451 -33.293 27.964  1.00 48.39 ?  339  ARG B CZ  1 
ATOM   4227 N NH1 . ARG C 1 116 ? -40.359 -33.272 28.724  1.00 50.82 ?  339  ARG B NH1 1 
ATOM   4228 N NH2 . ARG C 1 116 ? -41.491 -32.544 26.855  1.00 34.77 ?  339  ARG B NH2 1 
ATOM   4229 N N   . THR C 1 117 ? -43.598 -39.299 26.579  1.00 18.84 ?  340  THR B N   1 
ATOM   4230 C CA  . THR C 1 117 ? -44.634 -40.251 27.016  1.00 16.01 ?  340  THR B CA  1 
ATOM   4231 C C   . THR C 1 117 ? -44.106 -41.680 27.132  1.00 18.07 ?  340  THR B C   1 
ATOM   4232 O O   . THR C 1 117 ? -44.444 -42.386 28.093  1.00 18.11 ?  340  THR B O   1 
ATOM   4233 C CB  . THR C 1 117 ? -45.851 -40.236 26.090  1.00 21.69 ?  340  THR B CB  1 
ATOM   4234 O OG1 . THR C 1 117 ? -45.450 -40.481 24.735  1.00 26.58 ?  340  THR B OG1 1 
ATOM   4235 C CG2 . THR C 1 117 ? -46.488 -38.902 26.155  1.00 22.80 ?  340  THR B CG2 1 
ATOM   4236 N N   . ASP C 1 118 ? -43.311 -42.158 26.157  1.00 15.22 ?  341  ASP B N   1 
ATOM   4237 C CA  . ASP C 1 118 ? -42.882 -43.560 26.151  1.00 12.56 ?  341  ASP B CA  1 
ATOM   4238 C C   . ASP C 1 118 ? -41.377 -43.751 26.256  1.00 14.76 ?  341  ASP B C   1 
ATOM   4239 O O   . ASP C 1 118 ? -40.924 -44.907 26.280  1.00 14.33 ?  341  ASP B O   1 
ATOM   4240 C CB  . ASP C 1 118 ? -43.394 -44.317 24.900  1.00 15.98 ?  341  ASP B CB  1 
ATOM   4241 C CG  . ASP C 1 118 ? -42.890 -43.740 23.550  1.00 15.18 ?  341  ASP B CG  1 
ATOM   4242 O OD1 . ASP C 1 118 ? -42.140 -42.749 23.552  1.00 13.74 ?  341  ASP B OD1 1 
ATOM   4243 O OD2 . ASP C 1 118 ? -43.286 -44.279 22.470  1.00 19.07 -1 341  ASP B OD2 1 
ATOM   4244 N N   . GLY C 1 119 ? -40.596 -42.665 26.270  1.00 13.16 ?  342  GLY B N   1 
ATOM   4245 C CA  . GLY C 1 119 ? -39.144 -42.834 26.308  1.00 12.61 ?  342  GLY B CA  1 
ATOM   4246 C C   . GLY C 1 119 ? -38.525 -43.349 25.024  1.00 13.68 ?  342  GLY B C   1 
ATOM   4247 O O   . GLY C 1 119 ? -37.376 -43.826 25.051  1.00 11.02 ?  342  GLY B O   1 
ATOM   4248 N N   . SER C 1 120 ? -39.246 -43.300 23.901  1.00 10.76 ?  343  SER B N   1 
ATOM   4249 C CA  . SER C 1 120 ? -38.640 -43.605 22.613  1.00 9.86  ?  343  SER B CA  1 
ATOM   4250 C C   . SER C 1 120 ? -37.615 -42.519 22.240  1.00 10.23 ?  343  SER B C   1 
ATOM   4251 O O   . SER C 1 120 ? -37.741 -41.361 22.651  1.00 8.98  ?  343  SER B O   1 
ATOM   4252 C CB  . SER C 1 120 ? -39.712 -43.751 21.508  1.00 11.98 ?  343  SER B CB  1 
ATOM   4253 O OG  . SER C 1 120 ? -40.501 -42.566 21.399  1.00 13.34 ?  343  SER B OG  1 
ATOM   4254 N N   . THR C 1 121 ? -36.571 -42.923 21.498  1.00 9.82  ?  344  THR B N   1 
ATOM   4255 C CA  . THR C 1 121 ? -35.453 -42.003 21.221  1.00 10.17 ?  344  THR B CA  1 
ATOM   4256 C C   . THR C 1 121 ? -35.005 -42.133 19.765  1.00 9.49  ?  344  THR B C   1 
ATOM   4257 O O   . THR C 1 121 ? -35.321 -43.100 19.052  1.00 9.60  ?  344  THR B O   1 
ATOM   4258 C CB  . THR C 1 121 ? -34.231 -42.238 22.144  1.00 7.86  ?  344  THR B CB  1 
ATOM   4259 O OG1 . THR C 1 121 ? -33.650 -43.520 21.852  1.00 8.98  ?  344  THR B OG1 1 
ATOM   4260 C CG2 . THR C 1 121 ? -34.636 -42.145 23.624  1.00 8.17  ?  344  THR B CG2 1 
ATOM   4261 N N   . ARG C 1 122 ? -34.232 -41.124 19.318  1.00 9.42  ?  345  ARG B N   1 
ATOM   4262 C CA  . ARG C 1 122 ? -33.796 -41.063 17.933  1.00 8.50  ?  345  ARG B CA  1 
ATOM   4263 C C   . ARG C 1 122 ? -32.638 -40.075 17.870  1.00 8.91  ?  345  ARG B C   1 
ATOM   4264 O O   . ARG C 1 122 ? -32.542 -39.143 18.677  1.00 9.77  ?  345  ARG B O   1 
ATOM   4265 C CB  . ARG C 1 122 ? -34.938 -40.636 16.952  1.00 9.94  ?  345  ARG B CB  1 
ATOM   4266 C CG  . ARG C 1 122 ? -35.516 -39.254 17.317  1.00 12.76 ?  345  ARG B CG  1 
ATOM   4267 C CD  . ARG C 1 122 ? -37.000 -39.046 16.975  1.00 15.65 ?  345  ARG B CD  1 
ATOM   4268 N NE  . ARG C 1 122 ? -37.824 -40.066 17.620  1.00 12.90 ?  345  ARG B NE  1 
ATOM   4269 C CZ  . ARG C 1 122 ? -38.443 -39.927 18.787  1.00 12.79 ?  345  ARG B CZ  1 
ATOM   4270 N NH1 . ARG C 1 122 ? -38.441 -38.783 19.453  1.00 11.92 ?  345  ARG B NH1 1 
ATOM   4271 N NH2 . ARG C 1 122 ? -39.072 -40.976 19.301  1.00 12.43 ?  345  ARG B NH2 1 
ATOM   4272 N N   . GLY C 1 123 ? -31.759 -40.302 16.894  1.00 8.97  ?  346  GLY B N   1 
ATOM   4273 C CA  . GLY C 1 123 ? -30.589 -39.450 16.731  1.00 11.21 ?  346  GLY B CA  1 
ATOM   4274 C C   . GLY C 1 123 ? -30.241 -39.337 15.267  1.00 9.38  ?  346  GLY B C   1 
ATOM   4275 O O   . GLY C 1 123 ? -30.336 -40.330 14.524  1.00 12.27 ?  346  GLY B O   1 
ATOM   4276 N N   . HIS C 1 124 ? -29.817 -38.126 14.845  1.00 8.27  ?  347  HIS B N   1 
ATOM   4277 C CA  . HIS C 1 124 ? -29.542 -37.851 13.437  1.00 8.34  ?  347  HIS B CA  1 
ATOM   4278 C C   . HIS C 1 124 ? -28.339 -36.937 13.285  1.00 7.97  ?  347  HIS B C   1 
ATOM   4279 O O   . HIS C 1 124 ? -28.162 -35.974 14.037  1.00 9.15  ?  347  HIS B O   1 
ATOM   4280 C CB  . HIS C 1 124 ? -30.785 -37.218 12.740  1.00 10.88 ?  347  HIS B CB  1 
ATOM   4281 C CG  . HIS C 1 124 ? -31.900 -38.211 12.614  1.00 11.11 ?  347  HIS B CG  1 
ATOM   4282 N ND1 . HIS C 1 124 ? -31.954 -39.123 11.584  1.00 13.87 ?  347  HIS B ND1 1 
ATOM   4283 C CD2 . HIS C 1 124 ? -32.942 -38.492 13.439  1.00 13.40 ?  347  HIS B CD2 1 
ATOM   4284 C CE1 . HIS C 1 124 ? -33.024 -39.901 11.757  1.00 12.80 ?  347  HIS B CE1 1 
ATOM   4285 N NE2 . HIS C 1 124 ? -33.607 -39.575 12.894  1.00 12.03 ?  347  HIS B NE2 1 
ATOM   4286 N N   . LYS C 1 125 ? -27.532 -37.261 12.283  1.00 7.53  ?  348  LYS B N   1 
ATOM   4287 C CA  . LYS C 1 125 ? -26.432 -36.376 11.883  1.00 8.35  ?  348  LYS B CA  1 
ATOM   4288 C C   . LYS C 1 125 ? -26.960 -34.968 11.631  1.00 8.48  ?  348  LYS B C   1 
ATOM   4289 O O   . LYS C 1 125 ? -27.998 -34.777 10.980  1.00 8.60  ?  348  LYS B O   1 
ATOM   4290 C CB  . LYS C 1 125 ? -25.816 -36.940 10.603  1.00 9.86  ?  348  LYS B CB  1 
ATOM   4291 C CG  . LYS C 1 125 ? -24.734 -36.063 9.978   1.00 13.24 ?  348  LYS B CG  1 
ATOM   4292 C CD  . LYS C 1 125 ? -24.060 -36.947 8.922   1.00 18.09 ?  348  LYS B CD  1 
ATOM   4293 C CE  . LYS C 1 125 ? -22.912 -36.286 8.259   1.00 22.85 ?  348  LYS B CE  1 
ATOM   4294 N NZ  . LYS C 1 125 ? -22.559 -37.130 7.039   1.00 29.89 ?  348  LYS B NZ  1 
ATOM   4295 N N   . ALA C 1 126 ? -26.230 -33.954 12.121  1.00 7.56  ?  349  ALA B N   1 
ATOM   4296 C CA  . ALA C 1 126 ? -26.699 -32.587 12.007  1.00 6.28  ?  349  ALA B CA  1 
ATOM   4297 C C   . ALA C 1 126 ? -25.506 -31.644 11.942  1.00 5.79  ?  349  ALA B C   1 
ATOM   4298 O O   . ALA C 1 126 ? -24.493 -31.835 12.647  1.00 6.93  ?  349  ALA B O   1 
ATOM   4299 C CB  . ALA C 1 126 ? -27.579 -32.208 13.199  1.00 8.69  ?  349  ALA B CB  1 
ATOM   4300 N N   . THR C 1 127 ? -25.663 -30.565 11.158  1.00 6.23  ?  350  THR B N   1 
ATOM   4301 C CA  . THR C 1 127 ? -24.607 -29.551 11.043  1.00 5.43  ?  350  THR B CA  1 
ATOM   4302 C C   . THR C 1 127 ? -25.224 -28.189 11.294  1.00 7.30  ?  350  THR B C   1 
ATOM   4303 O O   . THR C 1 127 ? -26.289 -27.884 10.757  1.00 8.09  ?  350  THR B O   1 
ATOM   4304 C CB  . THR C 1 127 ? -23.971 -29.574 9.638   1.00 7.62  ?  350  THR B CB  1 
ATOM   4305 O OG1 . THR C 1 127 ? -23.543 -30.903 9.371   1.00 7.89  ?  350  THR B OG1 1 
ATOM   4306 C CG2 . THR C 1 127 ? -22.761 -28.608 9.509   1.00 7.65  ?  350  THR B CG2 1 
ATOM   4307 N N   . VAL C 1 128 ? -24.552 -27.360 12.100  1.00 6.54  ?  351  VAL B N   1 
ATOM   4308 C CA  . VAL C 1 128 ? -24.931 -25.947 12.280  1.00 6.63  ?  351  VAL B CA  1 
ATOM   4309 C C   . VAL C 1 128 ? -23.927 -25.059 11.553  1.00 7.41  ?  351  VAL B C   1 
ATOM   4310 O O   . VAL C 1 128 ? -22.710 -25.274 11.642  1.00 5.67  ?  351  VAL B O   1 
ATOM   4311 C CB  . VAL C 1 128 ? -25.068 -25.575 13.770  1.00 6.73  ?  351  VAL B CB  1 
ATOM   4312 C CG1 . VAL C 1 128 ? -23.796 -25.790 14.592  1.00 8.11  ?  351  VAL B CG1 1 
ATOM   4313 C CG2 . VAL C 1 128 ? -25.523 -24.100 13.902  1.00 9.20  ?  351  VAL B CG2 1 
ATOM   4314 N N   . TYR C 1 129 ? -24.449 -24.090 10.789  1.00 7.24  ?  352  TYR B N   1 
ATOM   4315 C CA  . TYR C 1 129 ? -23.700 -23.173 9.924   1.00 6.24  ?  352  TYR B CA  1 
ATOM   4316 C C   . TYR C 1 129 ? -23.646 -21.826 10.661  1.00 6.46  ?  352  TYR B C   1 
ATOM   4317 O O   . TYR C 1 129 ? -24.576 -20.997 10.561  1.00 9.12  ?  352  TYR B O   1 
ATOM   4318 C CB  . TYR C 1 129 ? -24.430 -23.057 8.571   1.00 6.85  ?  352  TYR B CB  1 
ATOM   4319 C CG  . TYR C 1 129 ? -24.331 -24.330 7.760   1.00 6.32  ?  352  TYR B CG  1 
ATOM   4320 C CD1 . TYR C 1 129 ? -25.104 -25.458 8.060   1.00 6.16  ?  352  TYR B CD1 1 
ATOM   4321 C CD2 . TYR C 1 129 ? -23.443 -24.415 6.703   1.00 6.77  ?  352  TYR B CD2 1 
ATOM   4322 C CE1 . TYR C 1 129 ? -24.936 -26.675 7.317   1.00 6.60  ?  352  TYR B CE1 1 
ATOM   4323 C CE2 . TYR C 1 129 ? -23.259 -25.581 5.954   1.00 8.63  ?  352  TYR B CE2 1 
ATOM   4324 C CZ  . TYR C 1 129 ? -24.025 -26.705 6.235   1.00 6.74  ?  352  TYR B CZ  1 
ATOM   4325 O OH  . TYR C 1 129 ? -23.846 -27.860 5.504   1.00 9.24  ?  352  TYR B OH  1 
ATOM   4326 N N   . THR C 1 130 ? -22.565 -21.607 11.445  1.00 6.52  ?  353  THR B N   1 
ATOM   4327 C CA  . THR C 1 130 ? -22.568 -20.404 12.310  1.00 7.55  ?  353  THR B CA  1 
ATOM   4328 C C   . THR C 1 130 ? -22.270 -19.129 11.532  1.00 7.81  ?  353  THR B C   1 
ATOM   4329 O O   . THR C 1 130 ? -22.413 -18.038 12.101  1.00 9.54  ?  353  THR B O   1 
ATOM   4330 C CB  . THR C 1 130 ? -21.564 -20.521 13.487  1.00 8.40  ?  353  THR B CB  1 
ATOM   4331 O OG1 . THR C 1 130 ? -20.209 -20.420 12.983  1.00 8.83  ?  353  THR B OG1 1 
ATOM   4332 C CG2 . THR C 1 130 ? -21.752 -21.841 14.258  1.00 8.72  ?  353  THR B CG2 1 
ATOM   4333 N N   . GLY C 1 131 ? -21.924 -19.240 10.254  1.00 8.63  ?  354  GLY B N   1 
ATOM   4334 C CA  . GLY C 1 131 ? -21.848 -18.095 9.348   1.00 8.13  ?  354  GLY B CA  1 
ATOM   4335 C C   . GLY C 1 131 ? -23.092 -17.850 8.510   1.00 11.17 ?  354  GLY B C   1 
ATOM   4336 O O   . GLY C 1 131 ? -23.086 -16.941 7.670   1.00 9.71  ?  354  GLY B O   1 
ATOM   4337 N N   . SER C 1 132 ? -24.152 -18.602 8.739   1.00 9.38  ?  355  SER B N   1 
ATOM   4338 C CA  . SER C 1 132 ? -25.383 -18.502 7.977   1.00 8.89  ?  355  SER B CA  1 
ATOM   4339 C C   . SER C 1 132 ? -26.163 -17.275 8.395   1.00 10.91 ?  355  SER B C   1 
ATOM   4340 O O   . SER C 1 132 ? -26.126 -16.851 9.552   1.00 10.97 ?  355  SER B O   1 
ATOM   4341 C CB  . SER C 1 132 ? -26.242 -19.746 8.228   1.00 10.57 ?  355  SER B CB  1 
ATOM   4342 O OG  . SER C 1 132 ? -27.617 -19.472 8.002   1.00 22.09 ?  355  SER B OG  1 
ATOM   4343 N N   . ALA C 1 133 ? -26.937 -16.733 7.444   1.00 12.37 ?  356  ALA B N   1 
ATOM   4344 C CA  . ALA C 1 133 ? -27.713 -15.537 7.753   1.00 14.33 ?  356  ALA B CA  1 
ATOM   4345 C C   . ALA C 1 133 ? -28.694 -15.758 8.890   1.00 16.63 ?  356  ALA B C   1 
ATOM   4346 O O   . ALA C 1 133 ? -29.029 -14.810 9.621   1.00 16.97 ?  356  ALA B O   1 
ATOM   4347 C CB  . ALA C 1 133 ? -28.460 -15.101 6.491   1.00 17.56 ?  356  ALA B CB  1 
ATOM   4348 N N   . ASP C 1 134 ? -29.207 -16.978 9.043   1.00 14.19 ?  357  ASP B N   1 
ATOM   4349 C CA  . ASP C 1 134 ? -30.249 -17.258 10.009  1.00 18.22 ?  357  ASP B CA  1 
ATOM   4350 C C   . ASP C 1 134 ? -29.715 -17.784 11.340  1.00 17.01 ?  357  ASP B C   1 
ATOM   4351 O O   . ASP C 1 134 ? -30.504 -18.027 12.249  1.00 19.60 ?  357  ASP B O   1 
ATOM   4352 C CB  . ASP C 1 134 ? -31.279 -18.236 9.385   1.00 23.50 ?  357  ASP B CB  1 
ATOM   4353 C CG  . ASP C 1 134 ? -31.770 -17.787 7.952   1.00 26.53 ?  357  ASP B CG  1 
ATOM   4354 O OD1 . ASP C 1 134 ? -32.153 -16.603 7.827   1.00 32.39 -1 357  ASP B OD1 1 
ATOM   4355 O OD2 . ASP C 1 134 ? -31.854 -18.614 6.969   1.00 29.64 ?  357  ASP B OD2 1 
ATOM   4356 N N   . PHE C 1 135 ? -28.386 -17.946 11.497  1.00 10.29 ?  358  PHE B N   1 
ATOM   4357 C CA  . PHE C 1 135 ? -27.821 -18.323 12.787  1.00 10.50 ?  358  PHE B CA  1 
ATOM   4358 C C   . PHE C 1 135 ? -28.024 -17.177 13.784  1.00 10.91 ?  358  PHE B C   1 
ATOM   4359 O O   . PHE C 1 135 ? -27.405 -16.121 13.643  1.00 11.56 ?  358  PHE B O   1 
ATOM   4360 C CB  . PHE C 1 135 ? -26.332 -18.635 12.629  1.00 9.41  ?  358  PHE B CB  1 
ATOM   4361 C CG  . PHE C 1 135 ? -25.645 -19.021 13.930  1.00 9.21  ?  358  PHE B CG  1 
ATOM   4362 C CD1 . PHE C 1 135 ? -25.824 -20.292 14.480  1.00 9.17  ?  358  PHE B CD1 1 
ATOM   4363 C CD2 . PHE C 1 135 ? -24.767 -18.142 14.541  1.00 10.07 ?  358  PHE B CD2 1 
ATOM   4364 C CE1 . PHE C 1 135 ? -25.193 -20.668 15.677  1.00 9.81  ?  358  PHE B CE1 1 
ATOM   4365 C CE2 . PHE C 1 135 ? -24.112 -18.512 15.719  1.00 9.39  ?  358  PHE B CE2 1 
ATOM   4366 C CZ  . PHE C 1 135 ? -24.312 -19.774 16.274  1.00 7.53  ?  358  PHE B CZ  1 
ATOM   4367 N N   . ALA C 1 136 ? -28.906 -17.339 14.774  1.00 10.14 ?  359  ALA B N   1 
ATOM   4368 C CA  . ALA C 1 136 ? -29.278 -16.210 15.633  1.00 11.38 ?  359  ALA B CA  1 
ATOM   4369 C C   . ALA C 1 136 ? -29.482 -16.669 17.072  1.00 11.92 ?  359  ALA B C   1 
ATOM   4370 O O   . ALA C 1 136 ? -30.544 -16.470 17.687  1.00 10.70 ?  359  ALA B O   1 
ATOM   4371 C CB  . ALA C 1 136 ? -30.517 -15.494 15.060  1.00 12.59 ?  359  ALA B CB  1 
ATOM   4372 N N   . PRO C 1 137 ? -28.461 -17.287 17.664  1.00 8.99  ?  360  PRO B N   1 
ATOM   4373 C CA  . PRO C 1 137 ? -28.626 -17.820 19.022  1.00 9.41  ?  360  PRO B CA  1 
ATOM   4374 C C   . PRO C 1 137 ? -29.010 -16.736 20.041  1.00 10.84 ?  360  PRO B C   1 
ATOM   4375 O O   . PRO C 1 137 ? -29.760 -17.032 20.971  1.00 11.22 ?  360  PRO B O   1 
ATOM   4376 C CB  . PRO C 1 137 ? -27.227 -18.432 19.322  1.00 8.50  ?  360  PRO B CB  1 
ATOM   4377 C CG  . PRO C 1 137 ? -26.304 -17.654 18.460  1.00 9.94  ?  360  PRO B CG  1 
ATOM   4378 C CD  . PRO C 1 137 ? -27.076 -17.419 17.147  1.00 10.57 ?  360  PRO B CD  1 
ATOM   4379 N N   . LYS C 1 138 ? -28.523 -15.492 19.897  1.00 11.58 ?  361  LYS B N   1 
ATOM   4380 C CA  . LYS C 1 138 ? -28.919 -14.424 20.834  1.00 11.53 ?  361  LYS B CA  1 
ATOM   4381 C C   . LYS C 1 138 ? -30.430 -14.191 20.785  1.00 13.49 ?  361  LYS B C   1 
ATOM   4382 O O   . LYS C 1 138 ? -31.041 -13.842 21.813  1.00 16.06 ?  361  LYS B O   1 
ATOM   4383 C CB  . LYS C 1 138 ? -28.152 -13.135 20.498  1.00 11.57 ?  361  LYS B CB  1 
ATOM   4384 C CG  . LYS C 1 138 ? -28.545 -11.845 21.318  1.00 15.28 ?  361  LYS B CG  1 
ATOM   4385 C CD  . LYS C 1 138 ? -28.387 -12.022 22.809  1.00 14.42 ?  361  LYS B CD  1 
ATOM   4386 C CE  . LYS C 1 138 ? -28.550 -10.620 23.500  1.00 17.24 ?  361  LYS B CE  1 
ATOM   4387 N NZ  . LYS C 1 138 ? -28.460 -10.775 24.960  1.00 18.59 ?  361  LYS B NZ  1 
ATOM   4388 N N   . LEU C 1 139 ? -31.039 -14.371 19.620  1.00 12.63 ?  362  LEU B N   1 
ATOM   4389 C CA  . LEU C 1 139 ? -32.513 -14.297 19.532  1.00 14.32 ?  362  LEU B CA  1 
ATOM   4390 C C   . LEU C 1 139 ? -33.215 -15.589 19.934  1.00 16.21 ?  362  LEU B C   1 
ATOM   4391 O O   . LEU C 1 139 ? -34.464 -15.630 19.945  1.00 17.21 ?  362  LEU B O   1 
ATOM   4392 C CB  . LEU C 1 139 ? -32.921 -13.914 18.103  1.00 13.57 ?  362  LEU B CB  1 
ATOM   4393 C CG  . LEU C 1 139 ? -32.453 -12.576 17.566  1.00 18.38 ?  362  LEU B CG  1 
ATOM   4394 C CD1 . LEU C 1 139 ? -32.936 -12.400 16.183  1.00 18.95 ?  362  LEU B CD1 1 
ATOM   4395 C CD2 . LEU C 1 139 ? -32.959 -11.467 18.443  1.00 17.68 ?  362  LEU B CD2 1 
ATOM   4396 N N   . GLY C 1 140 ? -32.471 -16.653 20.261  1.00 11.24 ?  363  GLY B N   1 
ATOM   4397 C CA  . GLY C 1 140 ? -33.054 -17.918 20.656  1.00 11.99 ?  363  GLY B CA  1 
ATOM   4398 C C   . GLY C 1 140 ? -33.310 -18.904 19.540  1.00 11.06 ?  363  GLY B C   1 
ATOM   4399 O O   . GLY C 1 140 ? -34.059 -19.873 19.765  1.00 13.01 ?  363  GLY B O   1 
ATOM   4400 N N   . ARG C 1 141 ? -32.716 -18.723 18.361  1.00 10.25 ?  364  ARG B N   1 
ATOM   4401 C CA  . ARG C 1 141 ? -32.999 -19.618 17.238  1.00 13.16 ?  364  ARG B CA  1 
ATOM   4402 C C   . ARG C 1 141 ? -31.724 -19.976 16.472  1.00 12.25 ?  364  ARG B C   1 
ATOM   4403 O O   . ARG C 1 141 ? -30.925 -19.097 16.094  1.00 11.45 ?  364  ARG B O   1 
ATOM   4404 C CB  . ARG C 1 141 ? -34.020 -19.001 16.267  1.00 17.17 ?  364  ARG B CB  1 
ATOM   4405 C CG  . ARG C 1 141 ? -35.467 -19.024 16.786  1.00 24.21 ?  364  ARG B CG  1 
ATOM   4406 C CD  . ARG C 1 141 ? -36.431 -18.372 15.805  1.00 32.74 ?  364  ARG B CD  1 
ATOM   4407 N NE  . ARG C 1 141 ? -36.107 -16.965 15.581  1.00 40.93 ?  364  ARG B NE  1 
ATOM   4408 C CZ  . ARG C 1 141 ? -36.577 -15.957 16.316  1.00 38.71 ?  364  ARG B CZ  1 
ATOM   4409 N NH1 . ARG C 1 141 ? -37.333 -16.166 17.389  1.00 39.38 ?  364  ARG B NH1 1 
ATOM   4410 N NH2 . ARG C 1 141 ? -36.264 -14.712 15.980  1.00 36.95 ?  364  ARG B NH2 1 
ATOM   4411 N N   . VAL C 1 142 ? -31.542 -21.285 16.235  1.00 10.40 ?  365  VAL B N   1 
ATOM   4412 C CA  . VAL C 1 142 ? -30.488 -21.747 15.333  1.00 12.91 ?  365  VAL B CA  1 
ATOM   4413 C C   . VAL C 1 142 ? -31.103 -22.825 14.465  1.00 11.39 ?  365  VAL B C   1 
ATOM   4414 O O   . VAL C 1 142 ? -32.175 -23.344 14.770  1.00 14.45 ?  365  VAL B O   1 
ATOM   4415 C CB  . VAL C 1 142 ? -29.248 -22.299 16.079  1.00 13.16 ?  365  VAL B CB  1 
ATOM   4416 C CG1 . VAL C 1 142 ? -28.656 -21.204 17.008  1.00 12.48 ?  365  VAL B CG1 1 
ATOM   4417 C CG2 . VAL C 1 142 ? -29.621 -23.483 16.895  1.00 14.24 ?  365  VAL B CG2 1 
ATOM   4418 N N   . GLN C 1 143 ? -30.474 -23.111 13.347  1.00 9.10  ?  366  GLN B N   1 
ATOM   4419 C CA  . GLN C 1 143 ? -30.964 -24.177 12.472  1.00 8.11  ?  366  GLN B CA  1 
ATOM   4420 C C   . GLN C 1 143 ? -29.943 -25.278 12.322  1.00 9.68  ?  366  GLN B C   1 
ATOM   4421 O O   . GLN C 1 143 ? -28.728 -25.023 12.372  1.00 10.45 ?  366  GLN B O   1 
ATOM   4422 C CB  . GLN C 1 143 ? -31.360 -23.691 11.086  1.00 10.31 ?  366  GLN B CB  1 
ATOM   4423 C CG  . GLN C 1 143 ? -32.247 -22.433 11.057  1.00 14.58 ?  366  GLN B CG  1 
ATOM   4424 C CD  . GLN C 1 143 ? -31.582 -21.187 11.547  1.00 21.09 ?  366  GLN B CD  1 
ATOM   4425 O OE1 . GLN C 1 143 ? -30.424 -20.929 11.161  1.00 20.07 ?  366  GLN B OE1 1 
ATOM   4426 N NE2 . GLN C 1 143 ? -32.296 -20.370 12.357  1.00 20.52 ?  366  GLN B NE2 1 
ATOM   4427 N N   . PHE C 1 144 ? -30.449 -26.488 12.096  1.00 6.64  ?  367  PHE B N   1 
ATOM   4428 C CA  . PHE C 1 144 ? -29.617 -27.668 11.866  1.00 7.50  ?  367  PHE B CA  1 
ATOM   4429 C C   . PHE C 1 144 ? -29.979 -28.333 10.542  1.00 8.61  ?  367  PHE B C   1 
ATOM   4430 O O   . PHE C 1 144 ? -31.144 -28.684 10.320  1.00 7.97  ?  367  PHE B O   1 
ATOM   4431 C CB  . PHE C 1 144 ? -29.766 -28.699 12.986  1.00 8.50  ?  367  PHE B CB  1 
ATOM   4432 C CG  . PHE C 1 144 ? -29.327 -28.182 14.313  1.00 6.84  ?  367  PHE B CG  1 
ATOM   4433 C CD1 . PHE C 1 144 ? -27.969 -28.188 14.645  1.00 7.83  ?  367  PHE B CD1 1 
ATOM   4434 C CD2 . PHE C 1 144 ? -30.226 -27.646 15.186  1.00 8.04  ?  367  PHE B CD2 1 
ATOM   4435 C CE1 . PHE C 1 144 ? -27.525 -27.654 15.876  1.00 8.01  ?  367  PHE B CE1 1 
ATOM   4436 C CE2 . PHE C 1 144 ? -29.812 -27.098 16.408  1.00 8.78  ?  367  PHE B CE2 1 
ATOM   4437 C CZ  . PHE C 1 144 ? -28.449 -27.113 16.736  1.00 9.10  ?  367  PHE B CZ  1 
ATOM   4438 N N   . GLU C 1 145 ? -28.961 -28.587 9.720   1.00 6.00  ?  368  GLU B N   1 
ATOM   4439 C CA  . GLU C 1 145 ? -29.077 -29.386 8.505   1.00 7.38  ?  368  GLU B CA  1 
ATOM   4440 C C   . GLU C 1 145 ? -28.903 -30.845 8.894   1.00 7.47  ?  368  GLU B C   1 
ATOM   4441 O O   . GLU C 1 145 ? -27.837 -31.231 9.412   1.00 8.30  ?  368  GLU B O   1 
ATOM   4442 C CB  . GLU C 1 145 ? -28.000 -28.979 7.486   1.00 7.89  ?  368  GLU B CB  1 
ATOM   4443 C CG  . GLU C 1 145 ? -28.075 -29.697 6.135   1.00 7.91  ?  368  GLU B CG  1 
ATOM   4444 C CD  . GLU C 1 145 ? -26.838 -29.344 5.313   1.00 10.13 ?  368  GLU B CD  1 
ATOM   4445 O OE1 . GLU C 1 145 ? -25.709 -29.682 5.811   1.00 10.53 ?  368  GLU B OE1 1 
ATOM   4446 O OE2 . GLU C 1 145 ? -27.013 -28.769 4.204   1.00 11.84 -1 368  GLU B OE2 1 
ATOM   4447 N N   . THR C 1 146 ? -29.940 -31.659 8.657   1.00 7.15  ?  369  THR B N   1 
ATOM   4448 C CA  . THR C 1 146 ? -29.937 -33.049 9.127   1.00 8.04  ?  369  THR B CA  1 
ATOM   4449 C C   . THR C 1 146 ? -30.121 -34.034 7.979   1.00 8.86  ?  369  THR B C   1 
ATOM   4450 O O   . THR C 1 146 ? -30.277 -33.659 6.813   1.00 7.61  ?  369  THR B O   1 
ATOM   4451 C CB  . THR C 1 146 ? -31.024 -33.294 10.190  1.00 8.08  ?  369  THR B CB  1 
ATOM   4452 O OG1 . THR C 1 146 ? -32.273 -33.537 9.506   1.00 7.72  ?  369  THR B OG1 1 
ATOM   4453 C CG2 . THR C 1 146 ? -31.165 -32.113 11.159  1.00 8.69  ?  369  THR B CG2 1 
ATOM   4454 N N   . ASP C 1 147 ? -30.035 -35.341 8.327   1.00 8.46  ?  370  ASP B N   1 
ATOM   4455 C CA  . ASP C 1 147 ? -30.298 -36.379 7.345   1.00 11.62 ?  370  ASP B CA  1 
ATOM   4456 C C   . ASP C 1 147 ? -31.720 -36.951 7.435   1.00 12.30 ?  370  ASP B C   1 
ATOM   4457 O O   . ASP C 1 147 ? -31.949 -38.068 6.956   1.00 13.50 ?  370  ASP B O   1 
ATOM   4458 C CB  . ASP C 1 147 ? -29.249 -37.500 7.481   1.00 14.37 ?  370  ASP B CB  1 
ATOM   4459 C CG  . ASP C 1 147 ? -29.419 -38.306 8.716   1.00 16.40 ?  370  ASP B CG  1 
ATOM   4460 O OD1 . ASP C 1 147 ? -30.173 -37.925 9.648   1.00 13.95 ?  370  ASP B OD1 1 
ATOM   4461 O OD2 . ASP C 1 147 ? -28.789 -39.409 8.750   1.00 20.82 -1 370  ASP B OD2 1 
ATOM   4462 N N   . THR C 1 148 ? -32.669 -36.223 8.019   1.00 10.03 ?  371  THR B N   1 
ATOM   4463 C CA  . THR C 1 148 ? -34.071 -36.669 8.029   1.00 10.24 ?  371  THR B CA  1 
ATOM   4464 C C   . THR C 1 148 ? -34.994 -35.515 7.644   1.00 11.65 ?  371  THR B C   1 
ATOM   4465 O O   . THR C 1 148 ? -34.693 -34.349 7.907   1.00 9.13  ?  371  THR B O   1 
ATOM   4466 C CB  . THR C 1 148 ? -34.481 -37.252 9.425   1.00 11.99 ?  371  THR B CB  1 
ATOM   4467 O OG1 . THR C 1 148 ? -35.801 -37.859 9.323   1.00 10.22 ?  371  THR B OG1 1 
ATOM   4468 C CG2 . THR C 1 148 ? -34.508 -36.214 10.559  1.00 9.68  ?  371  THR B CG2 1 
ATOM   4469 N N   . ASP C 1 149 ? -36.145 -35.850 7.041   1.00 12.93 ?  372  ASP B N   1 
ATOM   4470 C CA  . ASP C 1 149 ? -37.241 -34.891 6.942   1.00 10.62 ?  372  ASP B CA  1 
ATOM   4471 C C   . ASP C 1 149 ? -38.502 -35.407 7.628   1.00 11.24 ?  372  ASP B C   1 
ATOM   4472 O O   . ASP C 1 149 ? -39.605 -34.890 7.364   1.00 14.07 ?  372  ASP B O   1 
ATOM   4473 C CB  . ASP C 1 149 ? -37.532 -34.556 5.479   1.00 14.01 ?  372  ASP B CB  1 
ATOM   4474 C CG  . ASP C 1 149 ? -38.108 -35.746 4.692   1.00 21.76 ?  372  ASP B CG  1 
ATOM   4475 O OD1 . ASP C 1 149 ? -38.234 -36.892 5.183   1.00 19.24 ?  372  ASP B OD1 1 
ATOM   4476 O OD2 . ASP C 1 149 ? -38.479 -35.493 3.527   1.00 30.84 -1 372  ASP B OD2 1 
ATOM   4477 N N   . ARG C 1 150 ? -38.377 -36.393 8.521   1.00 11.12 ?  373  ARG B N   1 
ATOM   4478 C CA  . ARG C 1 150 ? -39.608 -36.928 9.088   1.00 12.91 ?  373  ARG B CA  1 
ATOM   4479 C C   . ARG C 1 150 ? -39.495 -37.504 10.490  1.00 14.72 ?  373  ARG B C   1 
ATOM   4480 O O   . ARG C 1 150 ? -40.503 -37.886 11.087  1.00 13.63 ?  373  ARG B O   1 
ATOM   4481 C CB  . ARG C 1 150 ? -40.180 -38.009 8.158   1.00 14.44 ?  373  ARG B CB  1 
ATOM   4482 C CG  . ARG C 1 150 ? -39.333 -39.251 7.913   1.00 18.94 ?  373  ARG B CG  1 
ATOM   4483 C CD  . ARG C 1 150 ? -39.817 -39.928 6.565   1.00 28.80 ?  373  ARG B CD  1 
ATOM   4484 N NE  . ARG C 1 150 ? -40.054 -38.927 5.512   1.00 36.41 ?  373  ARG B NE  1 
ATOM   4485 C CZ  . ARG C 1 150 ? -41.232 -38.496 5.042   1.00 37.18 ?  373  ARG B CZ  1 
ATOM   4486 N NH1 . ARG C 1 150 ? -42.390 -39.087 5.365   1.00 35.89 ?  373  ARG B NH1 1 
ATOM   4487 N NH2 . ARG C 1 150 ? -41.253 -37.438 4.220   1.00 30.29 ?  373  ARG B NH2 1 
ATOM   4488 N N   . ASP C 1 151 ? -38.284 -37.671 11.023  1.00 11.05 ?  374  ASP B N   1 
ATOM   4489 C CA  . ASP C 1 151 ? -38.227 -38.491 12.232  1.00 13.72 ?  374  ASP B CA  1 
ATOM   4490 C C   . ASP C 1 151 ? -38.354 -37.683 13.534  1.00 14.23 ?  374  ASP B C   1 
ATOM   4491 O O   . ASP C 1 151 ? -38.664 -38.277 14.584  1.00 18.14 ?  374  ASP B O   1 
ATOM   4492 C CB  . ASP C 1 151 ? -36.909 -39.289 12.204  1.00 11.03 ?  374  ASP B CB  1 
ATOM   4493 C CG  . ASP C 1 151 ? -36.896 -40.493 13.129  1.00 16.99 ?  374  ASP B CG  1 
ATOM   4494 O OD1 . ASP C 1 151 ? -37.937 -41.166 13.352  1.00 15.68 ?  374  ASP B OD1 1 
ATOM   4495 O OD2 . ASP C 1 151 ? -35.787 -40.811 13.669  1.00 13.90 -1 374  ASP B OD2 1 
ATOM   4496 N N   . PHE C 1 152 ? -38.101 -36.369 13.519  1.00 8.90  ?  375  PHE B N   1 
ATOM   4497 C CA  . PHE C 1 152 ? -38.189 -35.590 14.744  1.00 8.65  ?  375  PHE B CA  1 
ATOM   4498 C C   . PHE C 1 152 ? -39.631 -35.165 15.016  1.00 9.95  ?  375  PHE B C   1 
ATOM   4499 O O   . PHE C 1 152 ? -40.402 -34.854 14.089  1.00 11.62 ?  375  PHE B O   1 
ATOM   4500 C CB  . PHE C 1 152 ? -37.285 -34.341 14.709  1.00 9.58  ?  375  PHE B CB  1 
ATOM   4501 C CG  . PHE C 1 152 ? -35.814 -34.674 14.849  1.00 8.71  ?  375  PHE B CG  1 
ATOM   4502 C CD1 . PHE C 1 152 ? -35.336 -35.213 16.031  1.00 10.87 ?  375  PHE B CD1 1 
ATOM   4503 C CD2 . PHE C 1 152 ? -34.949 -34.486 13.766  1.00 8.86  ?  375  PHE B CD2 1 
ATOM   4504 C CE1 . PHE C 1 152 ? -33.977 -35.519 16.175  1.00 9.87  ?  375  PHE B CE1 1 
ATOM   4505 C CE2 . PHE C 1 152 ? -33.580 -34.791 13.896  1.00 11.14 ?  375  PHE B CE2 1 
ATOM   4506 C CZ  . PHE C 1 152 ? -33.110 -35.322 15.109  1.00 8.62  ?  375  PHE B CZ  1 
ATOM   4507 N N   . GLU C 1 153 ? -39.968 -35.125 16.300  1.00 10.72 ?  376  GLU B N   1 
ATOM   4508 C CA  . GLU C 1 153 ? -41.294 -34.702 16.773  1.00 11.74 ?  376  GLU B CA  1 
ATOM   4509 C C   . GLU C 1 153 ? -41.251 -33.277 17.332  1.00 12.63 ?  376  GLU B C   1 
ATOM   4510 O O   . GLU C 1 153 ? -40.211 -32.779 17.783  1.00 12.03 ?  376  GLU B O   1 
ATOM   4511 C CB  . GLU C 1 153 ? -41.807 -35.695 17.841  1.00 13.66 ?  376  GLU B CB  1 
ATOM   4512 C CG  . GLU C 1 153 ? -42.020 -37.104 17.214  1.00 13.83 ?  376  GLU B CG  1 
ATOM   4513 C CD  . GLU C 1 153 ? -42.095 -38.243 18.233  1.00 15.07 ?  376  GLU B CD  1 
ATOM   4514 O OE1 . GLU C 1 153 ? -42.439 -38.006 19.409  1.00 14.19 ?  376  GLU B OE1 1 
ATOM   4515 O OE2 . GLU C 1 153 ? -41.777 -39.384 17.821  1.00 17.53 -1 376  GLU B OE2 1 
ATOM   4516 N N   . ALA C 1 154 ? -42.410 -32.614 17.350  1.00 10.96 ?  377  ALA B N   1 
ATOM   4517 C CA  . ALA C 1 154 ? -42.469 -31.284 17.937  1.00 13.42 ?  377  ALA B CA  1 
ATOM   4518 C C   . ALA C 1 154 ? -42.694 -31.357 19.460  1.00 12.44 ?  377  ALA B C   1 
ATOM   4519 O O   . ALA C 1 154 ? -43.226 -32.343 19.988  1.00 11.57 ?  377  ALA B O   1 
ATOM   4520 C CB  . ALA C 1 154 ? -43.610 -30.458 17.275  1.00 17.24 ?  377  ALA B CB  1 
ATOM   4521 N N   . ASN C 1 155 ? -42.286 -30.277 20.148  1.00 11.46 ?  378  ASN B N   1 
ATOM   4522 C CA  . ASN C 1 155 ? -42.485 -30.086 21.585  1.00 12.73 ?  378  ASN B CA  1 
ATOM   4523 C C   . ASN C 1 155 ? -41.916 -31.267 22.359  1.00 14.78 ?  378  ASN B C   1 
ATOM   4524 O O   . ASN C 1 155 ? -42.491 -31.735 23.336  1.00 14.33 ?  378  ASN B O   1 
ATOM   4525 C CB  . ASN C 1 155 ? -43.993 -29.847 21.883  1.00 12.61 ?  378  ASN B CB  1 
ATOM   4526 C CG  . ASN C 1 155 ? -44.515 -28.616 21.133  1.00 15.22 ?  378  ASN B CG  1 
ATOM   4527 O OD1 . ASN C 1 155 ? -45.324 -28.727 20.222  1.00 22.17 ?  378  ASN B OD1 1 
ATOM   4528 N ND2 . ASN C 1 155 ? -43.977 -27.459 21.468  1.00 18.23 ?  378  ASN B ND2 1 
ATOM   4529 N N   . GLN C 1 156 ? -40.764 -31.795 21.889  1.00 10.60 ?  379  GLN B N   1 
ATOM   4530 C CA  . GLN C 1 156 ? -40.020 -32.832 22.625  1.00 11.85 ?  379  GLN B CA  1 
ATOM   4531 C C   . GLN C 1 156 ? -38.582 -32.353 22.808  1.00 11.95 ?  379  GLN B C   1 
ATOM   4532 O O   . GLN C 1 156 ? -38.014 -31.728 21.906  1.00 12.72 ?  379  GLN B O   1 
ATOM   4533 C CB  . GLN C 1 156 ? -39.992 -34.164 21.906  1.00 10.85 ?  379  GLN B CB  1 
ATOM   4534 C CG  . GLN C 1 156 ? -41.382 -34.778 21.626  1.00 12.82 ?  379  GLN B CG  1 
ATOM   4535 C CD  . GLN C 1 156 ? -42.082 -35.193 22.911  1.00 13.60 ?  379  GLN B CD  1 
ATOM   4536 O OE1 . GLN C 1 156 ? -41.465 -35.321 23.968  1.00 13.84 ?  379  GLN B OE1 1 
ATOM   4537 N NE2 . GLN C 1 156 ? -43.417 -35.336 22.827  1.00 18.33 ?  379  GLN B NE2 1 
ATOM   4538 N N   . ASN C 1 157 ? -38.015 -32.613 23.983  1.00 12.38 ?  380  ASN B N   1 
ATOM   4539 C CA  . ASN C 1 157 ? -36.647 -32.184 24.301  1.00 13.69 ?  380  ASN B CA  1 
ATOM   4540 C C   . ASN C 1 157 ? -35.642 -32.724 23.281  1.00 10.73 ?  380  ASN B C   1 
ATOM   4541 O O   . ASN C 1 157 ? -35.562 -33.937 23.062  1.00 9.97  ?  380  ASN B O   1 
ATOM   4542 C CB  . ASN C 1 157 ? -36.262 -32.696 25.696  1.00 14.50 ?  380  ASN B CB  1 
ATOM   4543 C CG  . ASN C 1 157 ? -36.959 -31.951 26.822  1.00 19.93 ?  380  ASN B CG  1 
ATOM   4544 O OD1 . ASN C 1 157 ? -37.793 -31.047 26.599  1.00 19.65 ?  380  ASN B OD1 1 
ATOM   4545 N ND2 . ASN C 1 157 ? -36.579 -32.290 28.054  1.00 23.25 ?  380  ASN B ND2 1 
ATOM   4546 N N   . THR C 1 158 ? -34.838 -31.809 22.700  1.00 9.78  ?  381  THR B N   1 
ATOM   4547 C CA  . THR C 1 158 ? -33.874 -32.130 21.629  1.00 8.76  ?  381  THR B CA  1 
ATOM   4548 C C   . THR C 1 158 ? -32.529 -31.518 21.982  1.00 6.99  ?  381  THR B C   1 
ATOM   4549 O O   . THR C 1 158 ? -32.463 -30.380 22.443  1.00 8.56  ?  381  THR B O   1 
ATOM   4550 C CB  . THR C 1 158 ? -34.391 -31.564 20.305  1.00 10.15 ?  381  THR B CB  1 
ATOM   4551 O OG1 . THR C 1 158 ? -35.768 -32.009 20.139  1.00 9.57  ?  381  THR B OG1 1 
ATOM   4552 C CG2 . THR C 1 158 ? -33.577 -32.064 19.105  1.00 9.48  ?  381  THR B CG2 1 
ATOM   4553 N N   . LYS C 1 159 ? -31.458 -32.298 21.809  1.00 7.27  ?  382  LYS B N   1 
ATOM   4554 C CA  . LYS C 1 159 ? -30.110 -31.811 22.136  1.00 7.72  ?  382  LYS B CA  1 
ATOM   4555 C C   . LYS C 1 159 ? -29.168 -31.964 20.942  1.00 6.62  ?  382  LYS B C   1 
ATOM   4556 O O   . LYS C 1 159 ? -29.256 -32.946 20.198  1.00 8.08  ?  382  LYS B O   1 
ATOM   4557 C CB  . LYS C 1 159 ? -29.509 -32.623 23.292  1.00 5.96  ?  382  LYS B CB  1 
ATOM   4558 C CG  . LYS C 1 159 ? -28.097 -32.212 23.704  1.00 8.76  ?  382  LYS B CG  1 
ATOM   4559 C CD  . LYS C 1 159 ? -27.528 -33.157 24.756  1.00 13.10 ?  382  LYS B CD  1 
ATOM   4560 C CE  . LYS C 1 159 ? -26.046 -32.783 24.998  1.00 13.15 ?  382  LYS B CE  1 
ATOM   4561 N NZ  . LYS C 1 159 ? -25.491 -33.625 26.131  1.00 18.00 ?  382  LYS B NZ  1 
ATOM   4562 N N   . PHE C 1 160 ? -28.285 -30.988 20.753  1.00 8.74  ?  383  PHE B N   1 
ATOM   4563 C CA  . PHE C 1 160 ? -27.187 -31.104 19.787  1.00 5.70  ?  383  PHE B CA  1 
ATOM   4564 C C   . PHE C 1 160 ? -25.890 -31.302 20.556  1.00 6.50  ?  383  PHE B C   1 
ATOM   4565 O O   . PHE C 1 160 ? -25.560 -30.478 21.424  1.00 7.75  ?  383  PHE B O   1 
ATOM   4566 C CB  . PHE C 1 160 ? -27.077 -29.838 18.931  1.00 6.17  ?  383  PHE B CB  1 
ATOM   4567 C CG  . PHE C 1 160 ? -25.907 -29.849 17.987  1.00 6.15  ?  383  PHE B CG  1 
ATOM   4568 C CD1 . PHE C 1 160 ? -25.975 -30.581 16.795  1.00 6.74  ?  383  PHE B CD1 1 
ATOM   4569 C CD2 . PHE C 1 160 ? -24.742 -29.156 18.290  1.00 6.01  ?  383  PHE B CD2 1 
ATOM   4570 C CE1 . PHE C 1 160 ? -24.917 -30.586 15.846  1.00 7.22  ?  383  PHE B CE1 1 
ATOM   4571 C CE2 . PHE C 1 160 ? -23.637 -29.169 17.356  1.00 7.23  ?  383  PHE B CE2 1 
ATOM   4572 C CZ  . PHE C 1 160 ? -23.742 -29.868 16.131  1.00 8.64  ?  383  PHE B CZ  1 
ATOM   4573 N N   . THR C 1 161 ? -25.194 -32.422 20.259  1.00 5.24  ?  384  THR B N   1 
ATOM   4574 C CA  . THR C 1 161 ? -23.865 -32.737 20.781  1.00 5.98  ?  384  THR B CA  1 
ATOM   4575 C C   . THR C 1 161 ? -22.864 -32.463 19.674  1.00 7.14  ?  384  THR B C   1 
ATOM   4576 O O   . THR C 1 161 ? -22.962 -33.098 18.613  1.00 6.16  ?  384  THR B O   1 
ATOM   4577 C CB  . THR C 1 161 ? -23.790 -34.204 21.211  1.00 6.08  ?  384  THR B CB  1 
ATOM   4578 O OG1 . THR C 1 161 ? -24.751 -34.408 22.258  1.00 7.46  ?  384  THR B OG1 1 
ATOM   4579 C CG2 . THR C 1 161 ? -22.371 -34.473 21.739  1.00 6.46  ?  384  THR B CG2 1 
ATOM   4580 N N   . PRO C 1 162 ? -21.904 -31.568 19.867  1.00 5.76  ?  385  PRO B N   1 
ATOM   4581 C CA  . PRO C 1 162 ? -20.910 -31.276 18.814  1.00 5.39  ?  385  PRO B CA  1 
ATOM   4582 C C   . PRO C 1 162 ? -19.852 -32.368 18.729  1.00 6.56  ?  385  PRO B C   1 
ATOM   4583 O O   . PRO C 1 162 ? -19.509 -33.007 19.726  1.00 7.09  ?  385  PRO B O   1 
ATOM   4584 C CB  . PRO C 1 162 ? -20.269 -29.946 19.289  1.00 6.75  ?  385  PRO B CB  1 
ATOM   4585 C CG  . PRO C 1 162 ? -20.318 -30.052 20.836  1.00 6.65  ?  385  PRO B CG  1 
ATOM   4586 C CD  . PRO C 1 162 ? -21.705 -30.754 21.099  1.00 6.08  ?  385  PRO B CD  1 
ATOM   4587 N N   . VAL C 1 163 ? -19.350 -32.604 17.516  1.00 6.45  ?  386  VAL B N   1 
ATOM   4588 C CA  . VAL C 1 163 ? -18.275 -33.578 17.300  1.00 6.26  ?  386  VAL B CA  1 
ATOM   4589 C C   . VAL C 1 163 ? -17.053 -32.903 16.674  1.00 6.05  ?  386  VAL B C   1 
ATOM   4590 O O   . VAL C 1 163 ? -15.911 -33.052 17.161  1.00 5.76  ?  386  VAL B O   1 
ATOM   4591 C CB  . VAL C 1 163 ? -18.743 -34.758 16.417  1.00 5.92  ?  386  VAL B CB  1 
ATOM   4592 C CG1 . VAL C 1 163 ? -17.540 -35.658 16.003  1.00 7.06  ?  386  VAL B CG1 1 
ATOM   4593 C CG2 . VAL C 1 163 ? -19.810 -35.617 17.188  1.00 7.20  ?  386  VAL B CG2 1 
ATOM   4594 N N   . GLY C 1 164 ? -17.257 -32.172 15.572  1.00 6.33  ?  387  GLY B N   1 
ATOM   4595 C CA  . GLY C 1 164 ? -16.091 -31.607 14.879  1.00 5.69  ?  387  GLY B CA  1 
ATOM   4596 C C   . GLY C 1 164 ? -16.529 -30.580 13.851  1.00 7.05  ?  387  GLY B C   1 
ATOM   4597 O O   . GLY C 1 164 ? -17.655 -30.070 13.913  1.00 6.93  ?  387  GLY B O   1 
ATOM   4598 N N   . VAL C 1 165 ? -15.617 -30.262 12.927  1.00 5.49  ?  388  VAL B N   1 
ATOM   4599 C CA  . VAL C 1 165 ? -15.909 -29.247 11.923  1.00 5.23  ?  388  VAL B CA  1 
ATOM   4600 C C   . VAL C 1 165 ? -15.758 -29.811 10.525  1.00 6.14  ?  388  VAL B C   1 
ATOM   4601 O O   . VAL C 1 165 ? -15.090 -30.829 10.307  1.00 6.07  ?  388  VAL B O   1 
ATOM   4602 C CB  . VAL C 1 165 ? -14.987 -28.013 12.109  1.00 4.10  ?  388  VAL B CB  1 
ATOM   4603 C CG1 . VAL C 1 165 ? -15.330 -27.313 13.438  1.00 7.33  ?  388  VAL B CG1 1 
ATOM   4604 C CG2 . VAL C 1 165 ? -13.467 -28.373 12.111  1.00 5.68  ?  388  VAL B CG2 1 
ATOM   4605 N N   . ILE C 1 166 ? -16.334 -29.084 9.547   1.00 6.83  ?  389  ILE B N   1 
ATOM   4606 C CA  . ILE C 1 166 ? -16.252 -29.506 8.149   1.00 5.41  ?  389  ILE B CA  1 
ATOM   4607 C C   . ILE C 1 166 ? -15.825 -28.346 7.264   1.00 7.13  ?  389  ILE B C   1 
ATOM   4608 O O   . ILE C 1 166 ? -15.870 -27.168 7.653   1.00 8.35  ?  389  ILE B O   1 
ATOM   4609 C CB  . ILE C 1 166 ? -17.586 -30.126 7.651   1.00 6.96  ?  389  ILE B CB  1 
ATOM   4610 C CG1 . ILE C 1 166 ? -18.690 -29.083 7.594   1.00 7.51  ?  389  ILE B CG1 1 
ATOM   4611 C CG2 . ILE C 1 166 ? -17.972 -31.312 8.527   1.00 6.87  ?  389  ILE B CG2 1 
ATOM   4612 C CD1 . ILE C 1 166 ? -19.939 -29.625 6.858   1.00 10.35 ?  389  ILE B CD1 1 
ATOM   4613 N N   . GLN C 1 167 ? -15.450 -28.687 6.020   1.00 6.10  ?  390  GLN B N   1 
ATOM   4614 C CA  . GLN C 1 167 ? -15.097 -27.677 5.004   1.00 6.06  ?  390  GLN B CA  1 
ATOM   4615 C C   . GLN C 1 167 ? -15.620 -28.168 3.648   1.00 7.18  ?  390  GLN B C   1 
ATOM   4616 O O   . GLN C 1 167 ? -15.593 -29.373 3.375   1.00 7.48  ?  390  GLN B O   1 
ATOM   4617 C CB  . GLN C 1 167 ? -13.566 -27.448 5.046   1.00 5.43  ?  390  GLN B CB  1 
ATOM   4618 C CG  . GLN C 1 167 ? -13.043 -26.376 4.014   1.00 6.58  ?  390  GLN B CG  1 
ATOM   4619 C CD  . GLN C 1 167 ? -12.476 -26.999 2.752   1.00 6.48  ?  390  GLN B CD  1 
ATOM   4620 O OE1 . GLN C 1 167 ? -12.645 -28.198 2.497   1.00 6.94  ?  390  GLN B OE1 1 
ATOM   4621 N NE2 . GLN C 1 167 ? -11.803 -26.188 1.936   1.00 6.13  ?  390  GLN B NE2 1 
ATOM   4622 N N   . ASP C 1 168 ? -16.103 -27.251 2.798   1.00 6.72  ?  391  ASP B N   1 
ATOM   4623 C CA  . ASP C 1 168 ? -16.741 -27.644 1.531   1.00 6.71  ?  391  ASP B CA  1 
ATOM   4624 C C   . ASP C 1 168 ? -16.029 -27.095 0.306   1.00 9.04  ?  391  ASP B C   1 
ATOM   4625 O O   . ASP C 1 168 ? -16.555 -27.222 -0.810  1.00 8.97  ?  391  ASP B O   1 
ATOM   4626 C CB  . ASP C 1 168 ? -18.186 -27.153 1.535   1.00 7.58  ?  391  ASP B CB  1 
ATOM   4627 C CG  . ASP C 1 168 ? -19.053 -27.980 2.459   1.00 8.91  ?  391  ASP B CG  1 
ATOM   4628 O OD1 . ASP C 1 168 ? -19.156 -29.213 2.250   1.00 10.65 ?  391  ASP B OD1 1 
ATOM   4629 O OD2 . ASP C 1 168 ? -19.680 -27.380 3.364   1.00 10.32 -1 391  ASP B OD2 1 
ATOM   4630 N N   . GLY C 1 169 ? -14.828 -26.551 0.469   1.00 6.71  ?  392  GLY B N   1 
ATOM   4631 C CA  . GLY C 1 169 ? -14.000 -26.121 -0.646  1.00 7.28  ?  392  GLY B CA  1 
ATOM   4632 C C   . GLY C 1 169 ? -13.741 -24.629 -0.609  1.00 8.17  ?  392  GLY B C   1 
ATOM   4633 O O   . GLY C 1 169 ? -14.330 -23.874 0.162   1.00 7.55  ?  392  GLY B O   1 
ATOM   4634 N N   . GLY C 1 170 ? -12.841 -24.217 -1.496  1.00 8.26  ?  393  GLY B N   1 
ATOM   4635 C CA  . GLY C 1 170 ? -12.559 -22.802 -1.695  1.00 8.48  ?  393  GLY B CA  1 
ATOM   4636 C C   . GLY C 1 170 ? -11.289 -22.673 -2.530  1.00 8.48  ?  393  GLY B C   1 
ATOM   4637 O O   . GLY C 1 170 ? -10.853 -23.623 -3.178  1.00 8.74  ?  393  GLY B O   1 
ATOM   4638 N N   . THR C 1 171 ? -10.707 -21.465 -2.504  1.00 8.75  ?  394  THR B N   1 
ATOM   4639 C CA  . THR C 1 171 ? -9.462  -21.242 -3.242  1.00 8.72  ?  394  THR B CA  1 
ATOM   4640 C C   . THR C 1 171 ? -8.283  -22.002 -2.657  1.00 11.17 ?  394  THR B C   1 
ATOM   4641 O O   . THR C 1 171 ? -7.296  -22.236 -3.381  1.00 11.69 ?  394  THR B O   1 
ATOM   4642 C CB  . THR C 1 171 ? -9.125  -19.746 -3.257  1.00 9.23  ?  394  THR B CB  1 
ATOM   4643 O OG1 . THR C 1 171 ? -8.996  -19.258 -1.936  1.00 10.03 ?  394  THR B OG1 1 
ATOM   4644 C CG2 . THR C 1 171 ? -10.171 -18.952 -4.055  1.00 9.68  ?  394  THR B CG2 1 
ATOM   4645 N N   . THR C 1 172 ? -8.373  -22.387 -1.384  1.00 9.21  ?  395  THR B N   1 
ATOM   4646 C CA  . THR C 1 172 ? -7.361  -23.213 -0.729  1.00 8.85  ?  395  THR B CA  1 
ATOM   4647 C C   . THR C 1 172 ? -8.043  -24.131 0.277   1.00 9.05  ?  395  THR B C   1 
ATOM   4648 O O   . THR C 1 172 ? -9.172  -23.875 0.710   1.00 8.63  ?  395  THR B O   1 
ATOM   4649 C CB  . THR C 1 172 ? -6.319  -22.364 0.045   1.00 14.44 ?  395  THR B CB  1 
ATOM   4650 O OG1 . THR C 1 172 ? -6.963  -21.768 1.183   1.00 16.42 ?  395  THR B OG1 1 
ATOM   4651 C CG2 . THR C 1 172 ? -5.804  -21.246 -0.813  1.00 16.29 ?  395  THR B CG2 1 
ATOM   4652 N N   . HIS C 1 173 ? -7.346  -25.222 0.618   1.00 9.53  ?  396  HIS B N   1 
ATOM   4653 C CA  . HIS C 1 173 ? -7.736  -26.008 1.789   1.00 8.57  ?  396  HIS B CA  1 
ATOM   4654 C C   . HIS C 1 173 ? -7.630  -25.142 3.046   1.00 8.38  ?  396  HIS B C   1 
ATOM   4655 O O   . HIS C 1 173 ? -6.923  -24.106 3.064   1.00 9.52  ?  396  HIS B O   1 
ATOM   4656 C CB  . HIS C 1 173 ? -6.803  -27.212 1.974   1.00 10.25 ?  396  HIS B CB  1 
ATOM   4657 C CG  . HIS C 1 173 ? -6.912  -28.268 0.915   1.00 8.19  ?  396  HIS B CG  1 
ATOM   4658 N ND1 . HIS C 1 173 ? -7.999  -28.406 0.066   1.00 8.44  ?  396  HIS B ND1 1 
ATOM   4659 C CD2 . HIS C 1 173 ? -6.026  -29.237 0.551   1.00 10.14 ?  396  HIS B CD2 1 
ATOM   4660 C CE1 . HIS C 1 173 ? -7.802  -29.445 -0.734  1.00 8.82  ?  396  HIS B CE1 1 
ATOM   4661 N NE2 . HIS C 1 173 ? -6.611  -29.961 -0.466  1.00 10.40 ?  396  HIS B NE2 1 
ATOM   4662 N N   . ARG C 1 174 ? -8.312  -25.578 4.118   1.00 7.68  ?  397  ARG B N   1 
ATOM   4663 C CA  . ARG C 1 174 ? -8.164  -24.943 5.444   1.00 7.44  ?  397  ARG B CA  1 
ATOM   4664 C C   . ARG C 1 174 ? -8.594  -23.471 5.420   1.00 6.84  ?  397  ARG B C   1 
ATOM   4665 O O   . ARG C 1 174 ? -8.182  -22.665 6.275   1.00 8.52  ?  397  ARG B O   1 
ATOM   4666 C CB  . ARG C 1 174 ? -6.732  -25.099 5.990   1.00 9.01  ?  397  ARG B CB  1 
ATOM   4667 C CG  . ARG C 1 174 ? -6.366  -26.536 6.230   1.00 8.22  ?  397  ARG B CG  1 
ATOM   4668 C CD  . ARG C 1 174 ? -4.958  -26.743 6.842   1.00 11.15 ?  397  ARG B CD  1 
ATOM   4669 N NE  . ARG C 1 174 ? -4.828  -26.130 8.170   1.00 13.57 ?  397  ARG B NE  1 
ATOM   4670 C CZ  . ARG C 1 174 ? -4.148  -25.018 8.412   1.00 17.19 ?  397  ARG B CZ  1 
ATOM   4671 N NH1 . ARG C 1 174 ? -3.592  -24.308 7.421   1.00 16.53 ?  397  ARG B NH1 1 
ATOM   4672 N NH2 . ARG C 1 174 ? -4.018  -24.600 9.671   1.00 15.55 ?  397  ARG B NH2 1 
ATOM   4673 N N   . ASN C 1 175 ? -9.553  -23.147 4.538   1.00 5.94  ?  398  ASN B N   1 
ATOM   4674 C CA  . ASN C 1 175 ? -10.079 -21.786 4.488   1.00 6.71  ?  398  ASN B CA  1 
ATOM   4675 C C   . ASN C 1 175 ? -11.248 -21.571 5.440   1.00 9.83  ?  398  ASN B C   1 
ATOM   4676 O O   . ASN C 1 175 ? -11.664 -20.434 5.611   1.00 8.92  ?  398  ASN B O   1 
ATOM   4677 C CB  . ASN C 1 175 ? -10.509 -21.406 3.042   1.00 7.14  ?  398  ASN B CB  1 
ATOM   4678 C CG  . ASN C 1 175 ? -11.641 -22.294 2.515   1.00 7.15  ?  398  ASN B CG  1 
ATOM   4679 O OD1 . ASN C 1 175 ? -11.713 -23.465 2.895   1.00 8.23  ?  398  ASN B OD1 1 
ATOM   4680 N ND2 . ASN C 1 175 ? -12.520 -21.748 1.649   1.00 7.67  ?  398  ASN B ND2 1 
ATOM   4681 N N   . GLU C 1 176 ? -11.743 -22.609 6.092   1.00 7.14  ?  399  GLU B N   1 
ATOM   4682 C CA  . GLU C 1 176 ? -12.749 -22.486 7.137   1.00 6.80  ?  399  GLU B CA  1 
ATOM   4683 C C   . GLU C 1 176 ? -12.570 -23.703 8.034   1.00 5.96  ?  399  GLU B C   1 
ATOM   4684 O O   . GLU C 1 176 ? -12.012 -24.716 7.576   1.00 6.80  ?  399  GLU B O   1 
ATOM   4685 C CB  . GLU C 1 176 ? -14.166 -22.453 6.550   1.00 8.88  ?  399  GLU B CB  1 
ATOM   4686 C CG  . GLU C 1 176 ? -14.471 -23.669 5.638   1.00 7.05  ?  399  GLU B CG  1 
ATOM   4687 C CD  . GLU C 1 176 ? -15.994 -23.880 5.353   1.00 6.88  ?  399  GLU B CD  1 
ATOM   4688 O OE1 . GLU C 1 176 ? -16.849 -23.409 6.135   1.00 8.55  ?  399  GLU B OE1 1 
ATOM   4689 O OE2 . GLU C 1 176 ? -16.272 -24.546 4.315   1.00 9.54  -1 399  GLU B OE2 1 
ATOM   4690 N N   . PRO C 1 177 ? -13.004 -23.649 9.290   1.00 7.28  ?  400  PRO B N   1 
ATOM   4691 C CA  . PRO C 1 177 ? -13.520 -22.502 10.052  1.00 5.60  ?  400  PRO B CA  1 
ATOM   4692 C C   . PRO C 1 177 ? -12.526 -21.331 10.105  1.00 7.55  ?  400  PRO B C   1 
ATOM   4693 O O   . PRO C 1 177 ? -11.325 -21.509 9.827   1.00 7.44  ?  400  PRO B O   1 
ATOM   4694 C CB  . PRO C 1 177 ? -13.686 -23.060 11.493  1.00 7.10  ?  400  PRO B CB  1 
ATOM   4695 C CG  . PRO C 1 177 ? -13.935 -24.563 11.260  1.00 8.27  ?  400  PRO B CG  1 
ATOM   4696 C CD  . PRO C 1 177 ? -13.046 -24.917 10.059  1.00 6.73  ?  400  PRO B CD  1 
ATOM   4697 N N   . GLN C 1 178 ? -13.066 -20.165 10.457  1.00 6.80  ?  401  GLN B N   1 
ATOM   4698 C CA  . GLN C 1 178 ? -12.273 -18.959 10.742  1.00 7.60  ?  401  GLN B CA  1 
ATOM   4699 C C   . GLN C 1 178 ? -12.364 -18.731 12.246  1.00 6.96  ?  401  GLN B C   1 
ATOM   4700 O O   . GLN C 1 178 ? -13.313 -18.122 12.734  1.00 6.66  ?  401  GLN B O   1 
ATOM   4701 C CB  . GLN C 1 178 ? -12.840 -17.761 9.940   1.00 10.02 ?  401  GLN B CB  1 
ATOM   4702 C CG  . GLN C 1 178 ? -12.630 -17.940 8.465   1.00 10.90 ?  401  GLN B CG  1 
ATOM   4703 C CD  . GLN C 1 178 ? -11.293 -17.502 8.027   1.00 20.81 ?  401  GLN B CD  1 
ATOM   4704 O OE1 . GLN C 1 178 ? -10.595 -16.766 8.746   1.00 22.64 ?  401  GLN B OE1 1 
ATOM   4705 N NE2 . GLN C 1 178 ? -10.866 -17.998 6.873   1.00 20.17 ?  401  GLN B NE2 1 
ATOM   4706 N N   . GLN C 1 179 ? -11.391 -19.297 12.992  1.00 7.45  ?  402  GLN B N   1 
ATOM   4707 C CA  . GLN C 1 179 ? -11.542 -19.304 14.448  1.00 6.53  ?  402  GLN B CA  1 
ATOM   4708 C C   . GLN C 1 179 ? -11.499 -17.900 15.050  1.00 7.52  ?  402  GLN B C   1 
ATOM   4709 O O   . GLN C 1 179 ? -11.945 -17.726 16.188  1.00 8.73  ?  402  GLN B O   1 
ATOM   4710 C CB  . GLN C 1 179 ? -10.485 -20.228 15.117  1.00 7.72  ?  402  GLN B CB  1 
ATOM   4711 C CG  . GLN C 1 179 ? -9.073  -19.617 15.071  1.00 5.97  ?  402  GLN B CG  1 
ATOM   4712 C CD  . GLN C 1 179 ? -8.131  -20.248 16.098  1.00 8.09  ?  402  GLN B CD  1 
ATOM   4713 O OE1 . GLN C 1 179 ? -8.567  -20.510 17.250  1.00 7.98  ?  402  GLN B OE1 1 
ATOM   4714 N NE2 . GLN C 1 179 ? -6.871  -20.531 15.688  1.00 7.04  ?  402  GLN B NE2 1 
ATOM   4715 N N   . TRP C 1 180 ? -11.001 -16.886 14.333  1.00 7.04  ?  403  TRP B N   1 
ATOM   4716 C CA  . TRP C 1 180 ? -10.954 -15.543 14.915  1.00 8.35  ?  403  TRP B CA  1 
ATOM   4717 C C   . TRP C 1 180 ? -12.011 -14.618 14.346  1.00 11.94 ?  403  TRP B C   1 
ATOM   4718 O O   . TRP C 1 180 ? -11.952 -13.390 14.575  1.00 11.53 ?  403  TRP B O   1 
ATOM   4719 C CB  . TRP C 1 180 ? -9.560  -14.935 14.690  1.00 8.45  ?  403  TRP B CB  1 
ATOM   4720 C CG  . TRP C 1 180 ? -8.472  -15.724 15.332  1.00 7.96  ?  403  TRP B CG  1 
ATOM   4721 C CD1 . TRP C 1 180 ? -7.326  -16.215 14.722  1.00 9.26  ?  403  TRP B CD1 1 
ATOM   4722 C CD2 . TRP C 1 180 ? -8.399  -16.137 16.705  1.00 7.64  ?  403  TRP B CD2 1 
ATOM   4723 N NE1 . TRP C 1 180 ? -6.539  -16.869 15.646  1.00 10.14 ?  403  TRP B NE1 1 
ATOM   4724 C CE2 . TRP C 1 180 ? -7.165  -16.835 16.863  1.00 9.75  ?  403  TRP B CE2 1 
ATOM   4725 C CE3 . TRP C 1 180 ? -9.208  -15.942 17.829  1.00 7.96  ?  403  TRP B CE3 1 
ATOM   4726 C CZ2 . TRP C 1 180 ? -6.748  -17.381 18.097  1.00 7.68  ?  403  TRP B CZ2 1 
ATOM   4727 C CZ3 . TRP C 1 180 ? -8.801  -16.516 19.066  1.00 9.95  ?  403  TRP B CZ3 1 
ATOM   4728 C CH2 . TRP C 1 180 ? -7.569  -17.213 19.179  1.00 8.07  ?  403  TRP B CH2 1 
ATOM   4729 N N   . VAL C 1 181 ? -13.003 -15.151 13.636  1.00 7.78  ?  404  VAL B N   1 
ATOM   4730 C CA  . VAL C 1 181 ? -14.110 -14.341 13.120  1.00 8.29  ?  404  VAL B CA  1 
ATOM   4731 C C   . VAL C 1 181 ? -15.342 -14.661 13.947  1.00 9.13  ?  404  VAL B C   1 
ATOM   4732 O O   . VAL C 1 181 ? -15.842 -15.796 13.916  1.00 10.00 ?  404  VAL B O   1 
ATOM   4733 C CB  . VAL C 1 181 ? -14.360 -14.612 11.630  1.00 7.90  ?  404  VAL B CB  1 
ATOM   4734 C CG1 . VAL C 1 181 ? -15.608 -13.876 11.134  1.00 9.70  ?  404  VAL B CG1 1 
ATOM   4735 C CG2 . VAL C 1 181 ? -13.144 -14.194 10.792  1.00 8.98  ?  404  VAL B CG2 1 
ATOM   4736 N N   . LEU C 1 182 ? -15.825 -13.682 14.727  1.00 8.34  ?  405  LEU B N   1 
ATOM   4737 C CA  . LEU C 1 182 ? -17.037 -13.904 15.513  1.00 9.17  ?  405  LEU B CA  1 
ATOM   4738 C C   . LEU C 1 182 ? -18.264 -14.056 14.606  1.00 9.00  ?  405  LEU B C   1 
ATOM   4739 O O   . LEU C 1 182 ? -18.422 -13.306 13.610  1.00 10.22 ?  405  LEU B O   1 
ATOM   4740 C CB  . LEU C 1 182 ? -17.279 -12.753 16.491  1.00 9.36  ?  405  LEU B CB  1 
ATOM   4741 C CG  . LEU C 1 182 ? -16.258 -12.692 17.650  1.00 9.72  ?  405  LEU B CG  1 
ATOM   4742 C CD1 . LEU C 1 182 ? -16.551 -11.401 18.392  1.00 13.58 ?  405  LEU B CD1 1 
ATOM   4743 C CD2 . LEU C 1 182 ? -16.407 -13.892 18.579  1.00 10.86 ?  405  LEU B CD2 1 
ATOM   4744 N N   . PRO C 1 183 ? -19.211 -14.926 14.979  1.00 9.66  ?  406  PRO B N   1 
ATOM   4745 C CA  . PRO C 1 183 ? -20.515 -14.935 14.301  1.00 10.63 ?  406  PRO B CA  1 
ATOM   4746 C C   . PRO C 1 183 ? -21.284 -13.652 14.576  1.00 12.09 ?  406  PRO B C   1 
ATOM   4747 O O   . PRO C 1 183 ? -20.970 -12.906 15.506  1.00 10.70 ?  406  PRO B O   1 
ATOM   4748 C CB  . PRO C 1 183 ? -21.275 -16.112 14.919  1.00 10.24 ?  406  PRO B CB  1 
ATOM   4749 C CG  . PRO C 1 183 ? -20.320 -16.856 15.813  1.00 12.16 ?  406  PRO B CG  1 
ATOM   4750 C CD  . PRO C 1 183 ? -19.149 -15.880 16.102  1.00 9.46  ?  406  PRO B CD  1 
ATOM   4751 N N   . SER C 1 184 ? -22.336 -13.422 13.759  1.00 10.95 ?  407  SER B N   1 
ATOM   4752 C CA  . SER C 1 184 ? -23.377 -12.428 14.094  1.00 11.55 ?  407  SER B CA  1 
ATOM   4753 C C   . SER C 1 184 ? -24.404 -13.084 14.979  1.00 10.35 ?  407  SER B C   1 
ATOM   4754 O O   . SER C 1 184 ? -25.263 -13.823 14.484  1.00 12.09 ?  407  SER B O   1 
ATOM   4755 C CB  . SER C 1 184 ? -24.030 -11.897 12.823  1.00 14.39 ?  407  SER B CB  1 
ATOM   4756 O OG  . SER C 1 184 ? -24.870 -10.825 13.197  1.00 23.06 ?  407  SER B OG  1 
ATOM   4757 N N   . TYR C 1 185 ? -24.295 -12.891 16.297  1.00 8.92  ?  408  TYR B N   1 
ATOM   4758 C CA  . TYR C 1 185 ? -25.105 -13.678 17.214  1.00 9.88  ?  408  TYR B CA  1 
ATOM   4759 C C   . TYR C 1 185 ? -26.617 -13.453 17.076  1.00 12.86 ?  408  TYR B C   1 
ATOM   4760 O O   . TYR C 1 185 ? -27.389 -14.347 17.451  1.00 11.09 ?  408  TYR B O   1 
ATOM   4761 C CB  . TYR C 1 185 ? -24.687 -13.408 18.666  1.00 9.72  ?  408  TYR B CB  1 
ATOM   4762 C CG  . TYR C 1 185 ? -23.267 -13.897 19.022  1.00 9.79  ?  408  TYR B CG  1 
ATOM   4763 C CD1 . TYR C 1 185 ? -22.985 -15.277 19.070  1.00 10.00 ?  408  TYR B CD1 1 
ATOM   4764 C CD2 . TYR C 1 185 ? -22.261 -12.986 19.390  1.00 10.91 ?  408  TYR B CD2 1 
ATOM   4765 C CE1 . TYR C 1 185 ? -21.740 -15.721 19.463  1.00 9.38  ?  408  TYR B CE1 1 
ATOM   4766 C CE2 . TYR C 1 185 ? -21.006 -13.414 19.765  1.00 11.63 ?  408  TYR B CE2 1 
ATOM   4767 C CZ  . TYR C 1 185 ? -20.756 -14.787 19.797  1.00 9.93  ?  408  TYR B CZ  1 
ATOM   4768 O OH  . TYR C 1 185 ? -19.493 -15.193 20.214  1.00 9.42  ?  408  TYR B OH  1 
ATOM   4769 N N   . SER C 1 186 ? -27.050 -12.301 16.548  1.00 11.69 ?  409  SER B N   1 
ATOM   4770 C CA  . SER C 1 186 ? -28.483 -12.065 16.347  1.00 12.97 ?  409  SER B CA  1 
ATOM   4771 C C   . SER C 1 186 ? -28.897 -12.211 14.884  1.00 15.87 ?  409  SER B C   1 
ATOM   4772 O O   . SER C 1 186 ? -29.999 -11.779 14.494  1.00 18.27 ?  409  SER B O   1 
ATOM   4773 C CB  . SER C 1 186 ? -28.841 -10.668 16.875  1.00 14.46 ?  409  SER B CB  1 
ATOM   4774 O OG  . SER C 1 186 ? -28.864 -10.686 18.278  1.00 14.00 ?  409  SER B OG  1 
ATOM   4775 N N   . GLY C 1 187 ? -28.052 -12.806 14.063  1.00 13.81 ?  410  GLY B N   1 
ATOM   4776 C CA  . GLY C 1 187 ? -28.375 -13.019 12.671  1.00 14.04 ?  410  GLY B CA  1 
ATOM   4777 C C   . GLY C 1 187 ? -27.964 -11.876 11.766  1.00 20.20 ?  410  GLY B C   1 
ATOM   4778 O O   . GLY C 1 187 ? -27.405 -10.856 12.190  1.00 24.97 ?  410  GLY B O   1 
ATOM   4779 N N   . ARG C 1 188 ? -28.207 -12.080 10.470  1.00 27.10 ?  411  ARG B N   1 
ATOM   4780 C CA  . ARG C 1 188 ? -27.586 -11.225 9.462   1.00 34.37 ?  411  ARG B CA  1 
ATOM   4781 C C   . ARG C 1 188 ? -27.884 -9.758  9.737   1.00 37.77 ?  411  ARG B C   1 
ATOM   4782 O O   . ARG C 1 188 ? -28.956 -9.405  10.230  1.00 34.68 ?  411  ARG B O   1 
ATOM   4783 C CB  . ARG C 1 188 ? -28.055 -11.606 8.051   1.00 37.62 ?  411  ARG B CB  1 
ATOM   4784 C CG  . ARG C 1 188 ? -27.118 -11.090 6.946   1.00 36.99 ?  411  ARG B CG  1 
ATOM   4785 C CD  . ARG C 1 188 ? -27.551 -11.555 5.557   1.00 40.97 ?  411  ARG B CD  1 
ATOM   4786 N NE  . ARG C 1 188 ? -28.978 -11.379 5.320   1.00 44.09 ?  411  ARG B NE  1 
ATOM   4787 C CZ  . ARG C 1 188 ? -29.522 -10.293 4.787   1.00 50.09 ?  411  ARG B CZ  1 
ATOM   4788 N NH1 . ARG C 1 188 ? -28.776 -9.260  4.407   1.00 47.60 ?  411  ARG B NH1 1 
ATOM   4789 N NH2 . ARG C 1 188 ? -30.849 -10.238 4.637   1.00 49.71 ?  411  ARG B NH2 1 
ATOM   4790 N N   . ASN C 1 189 ? -26.894 -8.911  9.465   1.00 42.17 ?  412  ASN B N   1 
ATOM   4791 C CA  . ASN C 1 189 ? -27.075 -7.463  9.529   1.00 50.16 ?  412  ASN B CA  1 
ATOM   4792 C C   . ASN C 1 189 ? -27.513 -7.015  10.932  1.00 46.93 ?  412  ASN B C   1 
ATOM   4793 O O   . ASN C 1 189 ? -28.449 -6.219  11.095  1.00 43.97 ?  412  ASN B O   1 
ATOM   4794 C CB  . ASN C 1 189 ? -28.084 -7.020  8.465   1.00 53.65 ?  412  ASN B CB  1 
ATOM   4795 C CG  . ASN C 1 189 ? -27.417 -6.435  7.235   1.00 67.08 ?  412  ASN B CG  1 
ATOM   4796 O OD1 . ASN C 1 189 ? -26.374 -5.778  7.323   1.00 76.74 ?  412  ASN B OD1 1 
ATOM   4797 N ND2 . ASN C 1 189 ? -27.997 -6.710  6.066   1.00 65.47 ?  412  ASN B ND2 1 
ATOM   4798 N N   . THR C 1 190 ? -26.833 -7.542  11.958  1.00 37.31 ?  413  THR B N   1 
ATOM   4799 C CA  . THR C 1 190 ? -27.053 -7.084  13.322  1.00 28.90 ?  413  THR B CA  1 
ATOM   4800 C C   . THR C 1 190 ? -25.701 -6.931  14.009  1.00 29.19 ?  413  THR B C   1 
ATOM   4801 O O   . THR C 1 190 ? -24.721 -7.562  13.627  1.00 32.34 ?  413  THR B O   1 
ATOM   4802 C CB  . THR C 1 190 ? -27.929 -8.038  14.122  1.00 31.90 ?  413  THR B CB  1 
ATOM   4803 O OG1 . THR C 1 190 ? -27.228 -9.277  14.255  1.00 23.62 ?  413  THR B OG1 1 
ATOM   4804 C CG2 . THR C 1 190 ? -29.259 -8.275  13.424  1.00 28.31 ?  413  THR B CG2 1 
ATOM   4805 N N   . HIS C 1 191 ? -25.663 -6.102  15.041  1.00 26.09 ?  414  HIS B N   1 
ATOM   4806 C CA  . HIS C 1 191 ? -24.422 -5.844  15.761  1.00 26.86 ?  414  HIS B CA  1 
ATOM   4807 C C   . HIS C 1 191 ? -24.367 -6.671  17.039  1.00 17.25 ?  414  HIS B C   1 
ATOM   4808 O O   . HIS C 1 191 ? -25.354 -6.768  17.769  1.00 18.68 ?  414  HIS B O   1 
ATOM   4809 C CB  . HIS C 1 191 ? -24.280 -4.355  16.102  1.00 29.85 ?  414  HIS B CB  1 
ATOM   4810 C CG  . HIS C 1 191 ? -23.910 -3.489  14.937  1.00 43.28 ?  414  HIS B CG  1 
ATOM   4811 N ND1 . HIS C 1 191 ? -24.560 -2.303  14.651  1.00 49.50 ?  414  HIS B ND1 1 
ATOM   4812 C CD2 . HIS C 1 191 ? -22.934 -3.617  14.005  1.00 42.30 ?  414  HIS B CD2 1 
ATOM   4813 C CE1 . HIS C 1 191 ? -24.008 -1.747  13.586  1.00 48.44 ?  414  HIS B CE1 1 
ATOM   4814 N NE2 . HIS C 1 191 ? -23.021 -2.524  13.174  1.00 50.54 ?  414  HIS B NE2 1 
ATOM   4815 N N   . ASN C 1 192 ? -23.203 -7.284  17.300  1.00 15.85 ?  415  ASN B N   1 
ATOM   4816 C CA  . ASN C 1 192 ? -23.023 -8.015  18.554  1.00 15.60 ?  415  ASN B CA  1 
ATOM   4817 C C   . ASN C 1 192 ? -22.964 -7.057  19.744  1.00 14.47 ?  415  ASN B C   1 
ATOM   4818 O O   . ASN C 1 192 ? -22.560 -5.892  19.608  1.00 17.52 ?  415  ASN B O   1 
ATOM   4819 C CB  . ASN C 1 192 ? -21.730 -8.843  18.505  1.00 13.75 ?  415  ASN B CB  1 
ATOM   4820 C CG  . ASN C 1 192 ? -21.824 -9.998  17.519  1.00 13.16 ?  415  ASN B CG  1 
ATOM   4821 O OD1 . ASN C 1 192 ? -22.914 -10.443 17.187  1.00 12.67 ?  415  ASN B OD1 1 
ATOM   4822 N ND2 . ASN C 1 192 ? -20.675 -10.484 17.065  1.00 11.60 ?  415  ASN B ND2 1 
ATOM   4823 N N   . VAL C 1 193 ? -23.323 -7.569  20.915  1.00 13.66 ?  416  VAL B N   1 
ATOM   4824 C CA  . VAL C 1 193 ? -23.342 -6.804  22.159  1.00 15.94 ?  416  VAL B CA  1 
ATOM   4825 C C   . VAL C 1 193 ? -22.640 -7.534  23.297  1.00 17.33 ?  416  VAL B C   1 
ATOM   4826 O O   . VAL C 1 193 ? -22.531 -8.773  23.326  1.00 13.11 ?  416  VAL B O   1 
ATOM   4827 C CB  . VAL C 1 193 ? -24.783 -6.464  22.574  1.00 16.66 ?  416  VAL B CB  1 
ATOM   4828 C CG1 . VAL C 1 193 ? -25.378 -5.536  21.523  1.00 17.67 ?  416  VAL B CG1 1 
ATOM   4829 C CG2 . VAL C 1 193 ? -25.611 -7.752  22.839  1.00 16.47 ?  416  VAL B CG2 1 
ATOM   4830 N N   . HIS C 1 194 ? -22.182 -6.726  24.283  1.00 13.64 ?  417  HIS B N   1 
ATOM   4831 C CA  . HIS C 1 194 ? -21.670 -7.208  25.568  1.00 16.66 ?  417  HIS B CA  1 
ATOM   4832 C C   . HIS C 1 194 ? -20.440 -8.111  25.405  1.00 12.82 ?  417  HIS B C   1 
ATOM   4833 O O   . HIS C 1 194 ? -20.254 -9.012  26.218  1.00 12.68 ?  417  HIS B O   1 
ATOM   4834 C CB  . HIS C 1 194 ? -22.739 -7.946  26.384  1.00 17.07 ?  417  HIS B CB  1 
ATOM   4835 C CG  . HIS C 1 194 ? -23.994 -7.150  26.577  1.00 20.47 ?  417  HIS B CG  1 
ATOM   4836 N ND1 . HIS C 1 194 ? -23.998 -5.913  27.194  1.00 26.28 ?  417  HIS B ND1 1 
ATOM   4837 C CD2 . HIS C 1 194 ? -25.275 -7.413  26.238  1.00 21.80 ?  417  HIS B CD2 1 
ATOM   4838 C CE1 . HIS C 1 194 ? -25.234 -5.441  27.209  1.00 25.82 ?  417  HIS B CE1 1 
ATOM   4839 N NE2 . HIS C 1 194 ? -26.029 -6.329  26.637  1.00 27.25 ?  417  HIS B NE2 1 
ATOM   4840 N N   . LEU C 1 195 ? -19.611 -7.829  24.401  1.00 13.87 ?  418  LEU B N   1 
ATOM   4841 C CA  . LEU C 1 195 ? -18.466 -8.681  24.074  1.00 11.51 ?  418  LEU B CA  1 
ATOM   4842 C C   . LEU C 1 195 ? -17.320 -8.510  25.067  1.00 13.95 ?  418  LEU B C   1 
ATOM   4843 O O   . LEU C 1 195 ? -17.011 -7.385  25.505  1.00 15.64 ?  418  LEU B O   1 
ATOM   4844 C CB  . LEU C 1 195 ? -17.952 -8.350  22.680  1.00 10.42 ?  418  LEU B CB  1 
ATOM   4845 C CG  . LEU C 1 195 ? -18.868 -8.635  21.494  1.00 11.99 ?  418  LEU B CG  1 
ATOM   4846 C CD1 . LEU C 1 195 ? -18.185 -8.164  20.181  1.00 13.64 ?  418  LEU B CD1 1 
ATOM   4847 C CD2 . LEU C 1 195 ? -19.250 -10.140 21.397  1.00 12.71 ?  418  LEU B CD2 1 
ATOM   4848 N N   . ALA C 1 196 ? -16.657 -9.615  25.385  1.00 11.13 ?  419  ALA B N   1 
ATOM   4849 C CA  . ALA C 1 196 ? -15.332 -9.528  25.965  1.00 10.86 ?  419  ALA B CA  1 
ATOM   4850 C C   . ALA C 1 196 ? -14.407 -8.851  24.962  1.00 11.18 ?  419  ALA B C   1 
ATOM   4851 O O   . ALA C 1 196 ? -14.531 -9.050  23.735  1.00 9.31  ?  419  ALA B O   1 
ATOM   4852 C CB  . ALA C 1 196 ? -14.823 -10.942 26.331  1.00 9.99  ?  419  ALA B CB  1 
ATOM   4853 N N   . PRO C 1 197 ? -13.462 -8.040  25.417  1.00 11.26 ?  420  PRO B N   1 
ATOM   4854 C CA  . PRO C 1 197 ? -12.686 -7.234  24.463  1.00 11.29 ?  420  PRO B CA  1 
ATOM   4855 C C   . PRO C 1 197 ? -11.673 -8.071  23.676  1.00 10.98 ?  420  PRO B C   1 
ATOM   4856 O O   . PRO C 1 197 ? -11.276 -9.184  24.061  1.00 10.13 ?  420  PRO B O   1 
ATOM   4857 C CB  . PRO C 1 197 ? -11.977 -6.221  25.380  1.00 12.59 ?  420  PRO B CB  1 
ATOM   4858 C CG  . PRO C 1 197 ? -11.816 -7.006  26.679  1.00 12.67 ?  420  PRO B CG  1 
ATOM   4859 C CD  . PRO C 1 197 ? -13.095 -7.787  26.822  1.00 13.16 ?  420  PRO B CD  1 
ATOM   4860 N N   . ALA C 1 198 ? -11.240 -7.510  22.549  1.00 10.23 ?  421  ALA B N   1 
ATOM   4861 C CA  . ALA C 1 198 ? -10.106 -8.075  21.822  1.00 9.75  ?  421  ALA B CA  1 
ATOM   4862 C C   . ALA C 1 198 ? -8.827  -7.944  22.656  1.00 12.42 ?  421  ALA B C   1 
ATOM   4863 O O   . ALA C 1 198 ? -8.709  -7.037  23.498  1.00 11.79 ?  421  ALA B O   1 
ATOM   4864 C CB  . ALA C 1 198 ? -9.901  -7.361  20.470  1.00 12.37 ?  421  ALA B CB  1 
ATOM   4865 N N   . VAL C 1 199 ? -7.865  -8.861  22.419  1.00 9.08  ?  422  VAL B N   1 
ATOM   4866 C CA  . VAL C 1 199 ? -6.569  -8.844  23.114  1.00 11.37 ?  422  VAL B CA  1 
ATOM   4867 C C   . VAL C 1 199 ? -5.410  -8.812  22.115  1.00 11.13 ?  422  VAL B C   1 
ATOM   4868 O O   . VAL C 1 199 ? -5.502  -9.317  20.986  1.00 10.90 ?  422  VAL B O   1 
ATOM   4869 C CB  . VAL C 1 199 ? -6.418  -10.052 24.080  1.00 9.79  ?  422  VAL B CB  1 
ATOM   4870 C CG1 . VAL C 1 199 ? -7.552  -10.057 25.109  1.00 10.37 ?  422  VAL B CG1 1 
ATOM   4871 C CG2 . VAL C 1 199 ? -6.332  -11.432 23.312  1.00 11.04 ?  422  VAL B CG2 1 
ATOM   4872 N N   . ALA C 1 200 ? -4.287  -8.241  22.556  1.00 10.94 ?  423  ALA B N   1 
ATOM   4873 C CA  . ALA C 1 200 ? -3.093  -8.176  21.718  1.00 12.25 ?  423  ALA B CA  1 
ATOM   4874 C C   . ALA C 1 200 ? -1.882  -7.979  22.615  1.00 13.79 ?  423  ALA B C   1 
ATOM   4875 O O   . ALA C 1 200 ? -2.018  -7.446  23.732  1.00 16.05 ?  423  ALA B O   1 
ATOM   4876 C CB  . ALA C 1 200 ? -3.183  -7.027  20.697  1.00 15.34 ?  423  ALA B CB  1 
ATOM   4877 N N   . PRO C 1 201 ? -0.692  -8.359  22.147  1.00 14.01 ?  424  PRO B N   1 
ATOM   4878 C CA  . PRO C 1 201 ? 0.535   -8.030  22.890  1.00 13.21 ?  424  PRO B CA  1 
ATOM   4879 C C   . PRO C 1 201 ? 0.726   -6.523  22.909  1.00 16.88 ?  424  PRO B C   1 
ATOM   4880 O O   . PRO C 1 201 ? 0.174   -5.806  22.075  1.00 15.40 ?  424  PRO B O   1 
ATOM   4881 C CB  . PRO C 1 201 ? 1.653   -8.736  22.107  1.00 14.37 ?  424  PRO B CB  1 
ATOM   4882 C CG  . PRO C 1 201 ? 1.090   -8.964  20.713  1.00 14.36 ?  424  PRO B CG  1 
ATOM   4883 C CD  . PRO C 1 201 ? -0.423  -9.050  20.866  1.00 11.38 ?  424  PRO B CD  1 
ATOM   4884 N N   . THR C 1 202 ? 1.506   -6.062  23.895  1.00 15.60 ?  425  THR B N   1 
ATOM   4885 C CA  . THR C 1 202 ? 1.685   -4.627  24.151  1.00 18.95 ?  425  THR B CA  1 
ATOM   4886 C C   . THR C 1 202 ? 3.056   -4.138  23.706  1.00 17.35 ?  425  THR B C   1 
ATOM   4887 O O   . THR C 1 202 ? 3.172   -3.118  23.034  1.00 21.68 ?  425  THR B O   1 
ATOM   4888 C CB  . THR C 1 202 ? 1.541   -4.301  25.661  1.00 21.34 ?  425  THR B CB  1 
ATOM   4889 O OG1 . THR C 1 202 ? 0.305   -4.791  26.233  1.00 23.74 ?  425  THR B OG1 1 
ATOM   4890 C CG2 . THR C 1 202 ? 1.627   -2.831  25.874  1.00 19.83 ?  425  THR B CG2 1 
ATOM   4891 N N   . PHE C 1 203 ? 4.089   -4.850  24.048  1.00 14.70 ?  426  PHE B N   1 
ATOM   4892 C CA  . PHE C 1 203 ? 5.441   -4.339  23.954  1.00 15.43 ?  426  PHE B CA  1 
ATOM   4893 C C   . PHE C 1 203 ? 6.238   -5.004  22.850  1.00 17.44 ?  426  PHE B C   1 
ATOM   4894 O O   . PHE C 1 203 ? 5.908   -6.105  22.381  1.00 14.56 ?  426  PHE B O   1 
ATOM   4895 C CB  . PHE C 1 203 ? 6.168   -4.552  25.282  1.00 14.42 ?  426  PHE B CB  1 
ATOM   4896 C CG  . PHE C 1 203 ? 5.628   -3.735  26.383  1.00 16.80 ?  426  PHE B CG  1 
ATOM   4897 C CD1 . PHE C 1 203 ? 5.911   -2.366  26.456  1.00 14.02 ?  426  PHE B CD1 1 
ATOM   4898 C CD2 . PHE C 1 203 ? 4.826   -4.294  27.334  1.00 16.85 ?  426  PHE B CD2 1 
ATOM   4899 C CE1 . PHE C 1 203 ? 5.390   -1.604  27.464  1.00 15.62 ?  426  PHE B CE1 1 
ATOM   4900 C CE2 . PHE C 1 203 ? 4.311   -3.569  28.346  1.00 18.76 ?  426  PHE B CE2 1 
ATOM   4901 C CZ  . PHE C 1 203 ? 4.597   -2.160  28.430  1.00 18.66 ?  426  PHE B CZ  1 
ATOM   4902 N N   . PRO C 1 204 ? 7.329   -4.371  22.424  1.00 15.50 ?  427  PRO B N   1 
ATOM   4903 C CA  . PRO C 1 204 ? 8.173   -4.974  21.395  1.00 17.73 ?  427  PRO B CA  1 
ATOM   4904 C C   . PRO C 1 204 ? 8.629   -6.343  21.828  1.00 15.20 ?  427  PRO B C   1 
ATOM   4905 O O   . PRO C 1 204 ? 9.081   -6.534  22.963  1.00 15.80 ?  427  PRO B O   1 
ATOM   4906 C CB  . PRO C 1 204 ? 9.364   -4.003  21.287  1.00 18.42 ?  427  PRO B CB  1 
ATOM   4907 C CG  . PRO C 1 204 ? 8.789   -2.694  21.689  1.00 18.98 ?  427  PRO B CG  1 
ATOM   4908 C CD  . PRO C 1 204 ? 7.769   -3.000  22.782  1.00 19.65 ?  427  PRO B CD  1 
ATOM   4909 N N   . GLY C 1 205 ? 8.557   -7.290  20.886  1.00 14.10 ?  428  GLY B N   1 
ATOM   4910 C CA  . GLY C 1 205 ? 9.025   -8.633  21.112  1.00 13.77 ?  428  GLY B CA  1 
ATOM   4911 C C   . GLY C 1 205 ? 8.004   -9.562  21.758  1.00 11.98 ?  428  GLY B C   1 
ATOM   4912 O O   . GLY C 1 205 ? 8.339   -10.725 22.003  1.00 11.71 ?  428  GLY B O   1 
ATOM   4913 N N   . GLU C 1 206 ? 6.829   -9.071  22.111  1.00 10.64 ?  429  GLU B N   1 
ATOM   4914 C CA  . GLU C 1 206 ? 5.787   -9.911  22.727  1.00 9.50  ?  429  GLU B CA  1 
ATOM   4915 C C   . GLU C 1 206 ? 4.812   -10.466 21.706  1.00 9.37  ?  429  GLU B C   1 
ATOM   4916 O O   . GLU C 1 206 ? 4.430   -9.803  20.727  1.00 10.48 ?  429  GLU B O   1 
ATOM   4917 C CB  . GLU C 1 206 ? 5.013   -9.073  23.733  1.00 11.72 ?  429  GLU B CB  1 
ATOM   4918 C CG  . GLU C 1 206 ? 5.787   -8.963  25.040  1.00 12.98 ?  429  GLU B CG  1 
ATOM   4919 C CD  . GLU C 1 206 ? 5.094   -8.042  26.034  1.00 18.80 ?  429  GLU B CD  1 
ATOM   4920 O OE1 . GLU C 1 206 ? 3.978   -7.450  25.664  1.00 14.39 ?  429  GLU B OE1 1 
ATOM   4921 O OE2 . GLU C 1 206 ? 5.607   -8.049  27.199  1.00 21.74 -1 429  GLU B OE2 1 
ATOM   4922 N N   . GLN C 1 207 ? 4.331   -11.666 22.026  1.00 8.02  ?  430  GLN B N   1 
ATOM   4923 C CA  . GLN C 1 207 ? 3.240   -12.309 21.299  1.00 9.04  ?  430  GLN B CA  1 
ATOM   4924 C C   . GLN C 1 207 ? 2.278   -12.905 22.306  1.00 7.87  ?  430  GLN B C   1 
ATOM   4925 O O   . GLN C 1 207 ? 2.638   -13.229 23.445  1.00 7.79  ?  430  GLN B O   1 
ATOM   4926 C CB  . GLN C 1 207 ? 3.751   -13.447 20.399  1.00 8.12  ?  430  GLN B CB  1 
ATOM   4927 C CG  . GLN C 1 207 ? 4.495   -12.936 19.157  1.00 10.29 ?  430  GLN B CG  1 
ATOM   4928 C CD  . GLN C 1 207 ? 5.109   -13.984 18.224  1.00 10.75 ?  430  GLN B CD  1 
ATOM   4929 O OE1 . GLN C 1 207 ? 5.630   -13.592 17.184  1.00 11.10 ?  430  GLN B OE1 1 
ATOM   4930 N NE2 . GLN C 1 207 ? 5.085   -15.268 18.570  1.00 10.35 ?  430  GLN B NE2 1 
ATOM   4931 N N   . LEU C 1 208 ? 1.051   -13.135 21.850  1.00 7.93  ?  431  LEU B N   1 
ATOM   4932 C CA  . LEU C 1 208 ? 0.135   -13.945 22.648  1.00 6.19  ?  431  LEU B CA  1 
ATOM   4933 C C   . LEU C 1 208 ? 0.648   -15.381 22.753  1.00 7.01  ?  431  LEU B C   1 
ATOM   4934 O O   . LEU C 1 208 ? 1.271   -15.912 21.816  1.00 8.46  ?  431  LEU B O   1 
ATOM   4935 C CB  . LEU C 1 208 ? -1.270  -13.979 22.002  1.00 6.87  ?  431  LEU B CB  1 
ATOM   4936 C CG  . LEU C 1 208 ? -1.983  -12.617 22.044  1.00 8.34  ?  431  LEU B CG  1 
ATOM   4937 C CD1 . LEU C 1 208 ? -3.183  -12.634 21.078  1.00 9.53  ?  431  LEU B CD1 1 
ATOM   4938 C CD2 . LEU C 1 208 ? -2.454  -12.281 23.486  1.00 10.29 ?  431  LEU B CD2 1 
ATOM   4939 N N   . LEU C 1 209 ? 0.356   -16.016 23.897  1.00 6.91  ?  432  LEU B N   1 
ATOM   4940 C CA  . LEU C 1 209 ? 0.547   -17.474 24.074  1.00 6.11  ?  432  LEU B CA  1 
ATOM   4941 C C   . LEU C 1 209 ? -0.824  -18.127 24.026  1.00 7.30  ?  432  LEU B C   1 
ATOM   4942 O O   . LEU C 1 209 ? -1.722  -17.725 24.790  1.00 7.89  ?  432  LEU B O   1 
ATOM   4943 C CB  . LEU C 1 209 ? 1.237   -17.799 25.403  1.00 7.01  ?  432  LEU B CB  1 
ATOM   4944 C CG  . LEU C 1 209 ? 1.550   -19.292 25.625  1.00 7.86  ?  432  LEU B CG  1 
ATOM   4945 C CD1 . LEU C 1 209 ? 2.592   -19.819 24.561  1.00 8.13  ?  432  LEU B CD1 1 
ATOM   4946 C CD2 . LEU C 1 209 ? 2.112   -19.545 27.054  1.00 10.07 ?  432  LEU B CD2 1 
ATOM   4947 N N   . PHE C 1 210 ? -0.987  -19.113 23.118  1.00 6.40  ?  433  PHE B N   1 
ATOM   4948 C CA  . PHE C 1 210 ? -2.250  -19.829 22.955  1.00 6.25  ?  433  PHE B CA  1 
ATOM   4949 C C   . PHE C 1 210 ? -2.169  -21.232 23.530  1.00 6.63  ?  433  PHE B C   1 
ATOM   4950 O O   . PHE C 1 210 ? -1.131  -21.903 23.458  1.00 8.39  ?  433  PHE B O   1 
ATOM   4951 C CB  . PHE C 1 210 ? -2.576  -19.912 21.465  1.00 7.33  ?  433  PHE B CB  1 
ATOM   4952 C CG  . PHE C 1 210 ? -2.755  -18.528 20.790  1.00 7.67  ?  433  PHE B CG  1 
ATOM   4953 C CD1 . PHE C 1 210 ? -3.903  -17.747 21.029  1.00 8.64  ?  433  PHE B CD1 1 
ATOM   4954 C CD2 . PHE C 1 210 ? -1.785  -18.057 19.908  1.00 10.92 ?  433  PHE B CD2 1 
ATOM   4955 C CE1 . PHE C 1 210 ? -4.066  -16.486 20.368  1.00 9.96  ?  433  PHE B CE1 1 
ATOM   4956 C CE2 . PHE C 1 210 ? -1.923  -16.823 19.245  1.00 10.95 ?  433  PHE B CE2 1 
ATOM   4957 C CZ  . PHE C 1 210 ? -3.083  -16.073 19.464  1.00 11.44 ?  433  PHE B CZ  1 
ATOM   4958 N N   . PHE C 1 211 ? -3.305  -21.687 24.049  1.00 5.46  ?  434  PHE B N   1 
ATOM   4959 C CA  . PHE C 1 211 ? -3.499  -23.066 24.500  1.00 6.60  ?  434  PHE B CA  1 
ATOM   4960 C C   . PHE C 1 211 ? -4.267  -23.766 23.371  1.00 7.43  ?  434  PHE B C   1 
ATOM   4961 O O   . PHE C 1 211 ? -5.432  -23.432 23.104  1.00 6.00  ?  434  PHE B O   1 
ATOM   4962 C CB  . PHE C 1 211 ? -4.252  -23.089 25.835  1.00 6.10  ?  434  PHE B CB  1 
ATOM   4963 C CG  . PHE C 1 211 ? -3.520  -22.351 26.946  1.00 5.57  ?  434  PHE B CG  1 
ATOM   4964 C CD1 . PHE C 1 211 ? -3.644  -20.951 27.088  1.00 7.42  ?  434  PHE B CD1 1 
ATOM   4965 C CD2 . PHE C 1 211 ? -2.716  -23.076 27.826  1.00 7.21  ?  434  PHE B CD2 1 
ATOM   4966 C CE1 . PHE C 1 211 ? -2.924  -20.274 28.096  1.00 8.18  ?  434  PHE B CE1 1 
ATOM   4967 C CE2 . PHE C 1 211 ? -2.022  -22.434 28.854  1.00 7.72  ?  434  PHE B CE2 1 
ATOM   4968 C CZ  . PHE C 1 211 ? -2.145  -21.026 28.988  1.00 6.36  ?  434  PHE B CZ  1 
ATOM   4969 N N   . ARG C 1 212 ? -3.578  -24.658 22.646  1.00 7.00  ?  435  ARG B N   1 
ATOM   4970 C CA  . ARG C 1 212 ? -4.046  -25.130 21.333  1.00 5.62  ?  435  ARG B CA  1 
ATOM   4971 C C   . ARG C 1 212 ? -4.521  -26.583 21.381  1.00 6.20  ?  435  ARG B C   1 
ATOM   4972 O O   . ARG C 1 212 ? -3.906  -27.461 21.999  1.00 5.81  ?  435  ARG B O   1 
ATOM   4973 C CB  . ARG C 1 212 ? -2.915  -25.007 20.322  1.00 7.81  ?  435  ARG B CB  1 
ATOM   4974 C CG  . ARG C 1 212 ? -3.221  -25.593 18.924  1.00 7.87  ?  435  ARG B CG  1 
ATOM   4975 C CD  . ARG C 1 212 ? -2.180  -25.063 17.886  1.00 8.08  ?  435  ARG B CD  1 
ATOM   4976 N NE  . ARG C 1 212 ? -2.575  -23.737 17.402  1.00 6.54  ?  435  ARG B NE  1 
ATOM   4977 C CZ  . ARG C 1 212 ? -2.233  -23.283 16.203  1.00 8.71  ?  435  ARG B CZ  1 
ATOM   4978 N NH1 . ARG C 1 212 ? -1.389  -23.973 15.435  1.00 9.52  ?  435  ARG B NH1 1 
ATOM   4979 N NH2 . ARG C 1 212 ? -2.748  -22.120 15.772  1.00 8.63  ?  435  ARG B NH2 1 
ATOM   4980 N N   . SER C 1 213 ? -5.615  -26.829 20.648  1.00 4.09  ?  436  SER B N   1 
ATOM   4981 C CA  . SER C 1 213 ? -6.117  -28.169 20.356  1.00 6.42  ?  436  SER B CA  1 
ATOM   4982 C C   . SER C 1 213 ? -6.342  -28.283 18.855  1.00 5.43  ?  436  SER B C   1 
ATOM   4983 O O   . SER C 1 213 ? -6.339  -27.292 18.114  1.00 8.51  ?  436  SER B O   1 
ATOM   4984 C CB  . SER C 1 213 ? -7.472  -28.461 21.060  1.00 6.18  ?  436  SER B CB  1 
ATOM   4985 O OG  . SER C 1 213 ? -7.356  -28.311 22.481  1.00 6.94  ?  436  SER B OG  1 
ATOM   4986 N N   . THR C 1 214 ? -6.606  -29.529 18.417  1.00 6.12  ?  437  THR B N   1 
ATOM   4987 C CA  . THR C 1 214 ? -6.996  -29.827 17.043  1.00 7.54  ?  437  THR B CA  1 
ATOM   4988 C C   . THR C 1 214 ? -8.423  -30.368 17.070  1.00 7.45  ?  437  THR B C   1 
ATOM   4989 O O   . THR C 1 214 ? -8.664  -31.458 17.613  1.00 9.56  ?  437  THR B O   1 
ATOM   4990 C CB  . THR C 1 214 ? -6.026  -30.834 16.430  1.00 9.42  ?  437  THR B CB  1 
ATOM   4991 O OG1 . THR C 1 214 ? -4.668  -30.381 16.607  1.00 8.51  ?  437  THR B OG1 1 
ATOM   4992 C CG2 . THR C 1 214 ? -6.257  -30.925 14.937  1.00 9.70  ?  437  THR B CG2 1 
ATOM   4993 N N   . MET C 1 215 ? -9.377  -29.614 16.500  1.00 5.22  ?  438  MET B N   1 
ATOM   4994 C CA  . MET C 1 215 ? -10.739 -30.127 16.454  1.00 5.67  ?  438  MET B CA  1 
ATOM   4995 C C   . MET C 1 215 ? -10.842 -31.329 15.513  1.00 7.20  ?  438  MET B C   1 
ATOM   4996 O O   . MET C 1 215 ? -10.218 -31.332 14.460  1.00 7.92  ?  438  MET B O   1 
ATOM   4997 C CB  . MET C 1 215 ? -11.725 -29.064 15.952  1.00 7.69  ?  438  MET B CB  1 
ATOM   4998 C CG  . MET C 1 215 ? -11.922 -27.940 16.963  1.00 8.54  ?  438  MET B CG  1 
ATOM   4999 S SD  . MET C 1 215 ? -12.864 -26.504 16.327  1.00 8.83  ?  438  MET B SD  1 
ATOM   5000 C CE  . MET C 1 215 ? -11.899 -25.886 14.953  1.00 10.48 ?  438  MET B CE  1 
ATOM   5001 N N   . PRO C 1 216 ? -11.682 -32.324 15.823  1.00 5.09  ?  439  PRO B N   1 
ATOM   5002 C CA  . PRO C 1 216 ? -11.964 -33.358 14.818  1.00 6.23  ?  439  PRO B CA  1 
ATOM   5003 C C   . PRO C 1 216 ? -12.507 -32.731 13.550  1.00 6.38  ?  439  PRO B C   1 
ATOM   5004 O O   . PRO C 1 216 ? -13.261 -31.747 13.601  1.00 5.88  ?  439  PRO B O   1 
ATOM   5005 C CB  . PRO C 1 216 ? -13.010 -34.268 15.503  1.00 5.91  ?  439  PRO B CB  1 
ATOM   5006 C CG  . PRO C 1 216 ? -12.746 -34.060 16.987  1.00 8.76  ?  439  PRO B CG  1 
ATOM   5007 C CD  . PRO C 1 216 ? -12.331 -32.600 17.114  1.00 6.76  ?  439  PRO B CD  1 
ATOM   5008 N N   . GLY C 1 217 ? -12.138 -33.311 12.401  1.00 6.15  ?  440  GLY B N   1 
ATOM   5009 C CA  . GLY C 1 217 ? -12.739 -32.945 11.124  1.00 6.54  ?  440  GLY B CA  1 
ATOM   5010 C C   . GLY C 1 217 ? -13.659 -34.062 10.656  1.00 5.93  ?  440  GLY B C   1 
ATOM   5011 O O   . GLY C 1 217 ? -13.315 -35.255 10.746  1.00 6.49  ?  440  GLY B O   1 
ATOM   5012 N N   . CYS C 1 218 ? -14.835 -33.666 10.149  1.00 6.41  ?  441  CYS B N   1 
ATOM   5013 C CA  . CYS C 1 218 ? -15.850 -34.645 9.752   1.00 7.09  ?  441  CYS B CA  1 
ATOM   5014 C C   . CYS C 1 218 ? -16.063 -34.752 8.248   1.00 7.75  ?  441  CYS B C   1 
ATOM   5015 O O   . CYS C 1 218 ? -16.718 -35.698 7.820   1.00 9.85  ?  441  CYS B O   1 
ATOM   5016 C CB  . CYS C 1 218 ? -17.217 -34.281 10.375  1.00 6.80  ?  441  CYS B CB  1 
ATOM   5017 S SG  . CYS C 1 218 ? -17.177 -34.253 12.219  1.00 9.06  ?  441  CYS B SG  1 
ATOM   5018 N N   . SER C 1 219 ? -15.569 -33.806 7.434   1.00 6.03  ?  442  SER B N   1 
ATOM   5019 C CA  . SER C 1 219 ? -15.570 -33.880 5.968   1.00 6.71  ?  442  SER B CA  1 
ATOM   5020 C C   . SER C 1 219 ? -14.792 -32.706 5.425   1.00 6.90  ?  442  SER B C   1 
ATOM   5021 O O   . SER C 1 219 ? -14.674 -31.638 6.092   1.00 6.07  ?  442  SER B O   1 
ATOM   5022 C CB  . SER C 1 219 ? -16.999 -33.916 5.351   1.00 9.83  ?  442  SER B CB  1 
ATOM   5023 O OG  . SER C 1 219 ? -17.673 -32.711 5.544   1.00 13.35 ?  442  SER B OG  1 
ATOM   5024 N N   . GLY C 1 220 ? -14.218 -32.924 4.230   1.00 6.64  ?  443  GLY B N   1 
ATOM   5025 C CA  . GLY C 1 220 ? -13.476 -31.881 3.550   1.00 7.27  ?  443  GLY B CA  1 
ATOM   5026 C C   . GLY C 1 220 ? -12.087 -31.677 4.134   1.00 7.63  ?  443  GLY B C   1 
ATOM   5027 O O   . GLY C 1 220 ? -11.484 -32.584 4.755   1.00 6.90  ?  443  GLY B O   1 
ATOM   5028 N N   . TYR C 1 221 ? -11.610 -30.432 3.993   1.00 6.27  ?  444  TYR B N   1 
ATOM   5029 C CA  . TYR C 1 221 ? -10.228 -30.054 4.329   1.00 7.06  ?  444  TYR B CA  1 
ATOM   5030 C C   . TYR C 1 221 ? -10.271 -28.881 5.313   1.00 5.76  ?  444  TYR B C   1 
ATOM   5031 O O   . TYR C 1 221 ? -9.774  -27.779 5.037   1.00 6.74  ?  444  TYR B O   1 
ATOM   5032 C CB  . TYR C 1 221 ? -9.412  -29.700 3.067   1.00 6.55  ?  444  TYR B CB  1 
ATOM   5033 C CG  . TYR C 1 221 ? -9.401  -30.801 2.001   1.00 6.79  ?  444  TYR B CG  1 
ATOM   5034 C CD1 . TYR C 1 221 ? -10.471 -30.919 1.090   1.00 7.39  ?  444  TYR B CD1 1 
ATOM   5035 C CD2 . TYR C 1 221 ? -8.345  -31.689 1.919   1.00 8.08  ?  444  TYR B CD2 1 
ATOM   5036 C CE1 . TYR C 1 221 ? -10.456 -31.902 0.159   1.00 8.44  ?  444  TYR B CE1 1 
ATOM   5037 C CE2 . TYR C 1 221 ? -8.328  -32.700 0.961   1.00 9.36  ?  444  TYR B CE2 1 
ATOM   5038 C CZ  . TYR C 1 221 ? -9.405  -32.784 0.087   1.00 10.02 ?  444  TYR B CZ  1 
ATOM   5039 O OH  . TYR C 1 221 ? -9.436  -33.782 -0.909  1.00 12.33 ?  444  TYR B OH  1 
ATOM   5040 N N   . PRO C 1 222 ? -10.868 -29.059 6.485   1.00 6.01  ?  445  PRO B N   1 
ATOM   5041 C CA  . PRO C 1 222 ? -11.024 -27.924 7.410   1.00 5.90  ?  445  PRO B CA  1 
ATOM   5042 C C   . PRO C 1 222 ? -9.721  -27.507 8.095   1.00 6.22  ?  445  PRO B C   1 
ATOM   5043 O O   . PRO C 1 222 ? -8.803  -28.309 8.293   1.00 7.21  ?  445  PRO B O   1 
ATOM   5044 C CB  . PRO C 1 222 ? -12.022 -28.450 8.463   1.00 5.47  ?  445  PRO B CB  1 
ATOM   5045 C CG  . PRO C 1 222 ? -11.766 -29.959 8.464   1.00 6.70  ?  445  PRO B CG  1 
ATOM   5046 C CD  . PRO C 1 222 ? -11.523 -30.291 6.974   1.00 6.24  ?  445  PRO B CD  1 
ATOM   5047 N N   . ASN C 1 223 ? -9.689  -26.231 8.505   1.00 7.04  ?  446  ASN B N   1 
ATOM   5048 C CA  . ASN C 1 223 ? -8.674  -25.748 9.450   1.00 6.80  ?  446  ASN B CA  1 
ATOM   5049 C C   . ASN C 1 223 ? -9.093  -26.160 10.854  1.00 6.86  ?  446  ASN B C   1 
ATOM   5050 O O   . ASN C 1 223 ? -10.060 -25.607 11.419  1.00 7.01  ?  446  ASN B O   1 
ATOM   5051 C CB  . ASN C 1 223 ? -8.508  -24.231 9.353   1.00 7.43  ?  446  ASN B CB  1 
ATOM   5052 C CG  . ASN C 1 223 ? -7.352  -23.752 10.220  1.00 10.00 ?  446  ASN B CG  1 
ATOM   5053 O OD1 . ASN C 1 223 ? -6.807  -24.543 11.007  1.00 9.58  ?  446  ASN B OD1 1 
ATOM   5054 N ND2 . ASN C 1 223 ? -6.947  -22.491 10.069  1.00 10.76 ?  446  ASN B ND2 1 
ATOM   5055 N N   . MET C 1 224 ? -8.407  -27.175 11.382  1.00 6.14  ?  447  MET B N   1 
ATOM   5056 C CA  . MET C 1 224 ? -8.821  -27.750 12.634  1.00 7.34  ?  447  MET B CA  1 
ATOM   5057 C C   . MET C 1 224 ? -8.123  -27.090 13.840  1.00 6.32  ?  447  MET B C   1 
ATOM   5058 O O   . MET C 1 224 ? -8.367  -27.490 14.978  1.00 7.27  ?  447  MET B O   1 
ATOM   5059 C CB  . MET C 1 224 ? -8.543  -29.262 12.663  1.00 7.78  ?  447  MET B CB  1 
ATOM   5060 C CG  . MET C 1 224 ? -9.689  -30.104 12.057  1.00 9.20  ?  447  MET B CG  1 
ATOM   5061 S SD  . MET C 1 224 ? -9.291  -31.643 11.264  1.00 8.11  ?  447  MET B SD  1 
ATOM   5062 C CE  . MET C 1 224 ? -7.996  -31.266 10.091  1.00 9.18  ?  447  MET B CE  1 
ATOM   5063 N N   . ASP C 1 225 ? -7.256  -26.089 13.621  1.00 6.67  ?  448  ASP B N   1 
ATOM   5064 C CA  . ASP C 1 225 ? -6.609  -25.442 14.755  1.00 7.33  ?  448  ASP B CA  1 
ATOM   5065 C C   . ASP C 1 225 ? -7.606  -24.688 15.622  1.00 6.30  ?  448  ASP B C   1 
ATOM   5066 O O   . ASP C 1 225 ? -8.461  -23.945 15.106  1.00 8.73  ?  448  ASP B O   1 
ATOM   5067 C CB  . ASP C 1 225 ? -5.560  -24.442 14.276  1.00 7.06  ?  448  ASP B CB  1 
ATOM   5068 C CG  . ASP C 1 225 ? -4.411  -25.084 13.541  1.00 10.30 ?  448  ASP B CG  1 
ATOM   5069 O OD1 . ASP C 1 225 ? -4.113  -26.275 13.786  1.00 10.25 ?  448  ASP B OD1 1 
ATOM   5070 O OD2 . ASP C 1 225 ? -3.826  -24.361 12.702  1.00 11.42 -1 448  ASP B OD2 1 
ATOM   5071 N N   . LEU C 1 226 ? -7.458  -24.815 16.945  1.00 6.17  ?  449  LEU B N   1 
ATOM   5072 C CA  . LEU C 1 226 ? -8.356  -24.097 17.861  1.00 5.58  ?  449  LEU B CA  1 
ATOM   5073 C C   . LEU C 1 226 ? -7.547  -23.614 19.062  1.00 6.21  ?  449  LEU B C   1 
ATOM   5074 O O   . LEU C 1 226 ? -7.066  -24.415 19.888  1.00 5.98  ?  449  LEU B O   1 
ATOM   5075 C CB  . LEU C 1 226 ? -9.547  -24.973 18.307  1.00 6.74  ?  449  LEU B CB  1 
ATOM   5076 C CG  . LEU C 1 226 ? -10.548 -24.131 19.113  1.00 8.07  ?  449  LEU B CG  1 
ATOM   5077 C CD1 . LEU C 1 226 ? -11.271 -23.103 18.284  1.00 6.30  ?  449  LEU B CD1 1 
ATOM   5078 C CD2 . LEU C 1 226 ? -11.533 -25.120 19.801  1.00 8.33  ?  449  LEU B CD2 1 
ATOM   5079 N N   . ASP C 1 227 ? -7.373  -22.302 19.131  1.00 6.44  ?  450  ASP B N   1 
ATOM   5080 C CA  . ASP C 1 227 ? -6.577  -21.653 20.190  1.00 6.61  ?  450  ASP B CA  1 
ATOM   5081 C C   . ASP C 1 227 ? -7.477  -20.992 21.232  1.00 6.67  ?  450  ASP B C   1 
ATOM   5082 O O   . ASP C 1 227 ? -8.356  -20.229 20.869  1.00 7.38  ?  450  ASP B O   1 
ATOM   5083 C CB  . ASP C 1 227 ? -5.700  -20.574 19.547  1.00 6.53  ?  450  ASP B CB  1 
ATOM   5084 C CG  . ASP C 1 227 ? -4.652  -21.168 18.639  1.00 7.65  ?  450  ASP B CG  1 
ATOM   5085 O OD1 . ASP C 1 227 ? -3.959  -22.101 19.112  1.00 7.79  ?  450  ASP B OD1 1 
ATOM   5086 O OD2 . ASP C 1 227 ? -4.506  -20.688 17.476  1.00 9.20  -1 450  ASP B OD2 1 
ATOM   5087 N N   . CYS C 1 228 ? -7.255  -21.265 22.524  1.00 6.35  ?  451  CYS B N   1 
ATOM   5088 C CA  . CYS C 1 228 ? -7.981  -20.549 23.557  1.00 5.61  ?  451  CYS B CA  1 
ATOM   5089 C C   . CYS C 1 228 ? -7.000  -19.746 24.406  1.00 6.53  ?  451  CYS B C   1 
ATOM   5090 O O   . CYS C 1 228 ? -5.781  -19.995 24.407  1.00 6.77  ?  451  CYS B O   1 
ATOM   5091 C CB  . CYS C 1 228 ? -8.844  -21.504 24.444  1.00 7.07  ?  451  CYS B CB  1 
ATOM   5092 S SG  . CYS C 1 228 ? -7.959  -22.716 25.435  1.00 6.42  ?  451  CYS B SG  1 
ATOM   5093 N N   . LEU C 1 229 ? -7.545  -18.699 25.044  1.00 5.78  ?  452  LEU B N   1 
ATOM   5094 C CA  . LEU C 1 229 ? -6.692  -17.767 25.809  1.00 6.15  ?  452  LEU B CA  1 
ATOM   5095 C C   . LEU C 1 229 ? -6.375  -18.289 27.200  1.00 7.96  ?  452  LEU B C   1 
ATOM   5096 O O   . LEU C 1 229 ? -5.333  -17.908 27.778  1.00 8.22  ?  452  LEU B O   1 
ATOM   5097 C CB  . LEU C 1 229 ? -7.340  -16.372 25.883  1.00 7.53  ?  452  LEU B CB  1 
ATOM   5098 C CG  . LEU C 1 229 ? -7.630  -15.684 24.543  1.00 8.08  ?  452  LEU B CG  1 
ATOM   5099 C CD1 . LEU C 1 229 ? -8.317  -14.299 24.829  1.00 8.40  ?  452  LEU B CD1 1 
ATOM   5100 C CD2 . LEU C 1 229 ? -6.368  -15.503 23.681  1.00 10.47 ?  452  LEU B CD2 1 
ATOM   5101 N N   . LEU C 1 230 ? -7.254  -19.122 27.759  1.00 7.87  ?  453  LEU B N   1 
ATOM   5102 C CA  . LEU C 1 230 ? -7.104  -19.734 29.057  1.00 7.14  ?  453  LEU B CA  1 
ATOM   5103 C C   . LEU C 1 230 ? -7.617  -21.162 28.944  1.00 6.87  ?  453  LEU B C   1 
ATOM   5104 O O   . LEU C 1 230 ? -8.700  -21.369 28.355  1.00 6.87  ?  453  LEU B O   1 
ATOM   5105 C CB  . LEU C 1 230 ? -7.947  -18.992 30.124  1.00 7.89  ?  453  LEU B CB  1 
ATOM   5106 C CG  . LEU C 1 230 ? -7.693  -17.481 30.292  1.00 5.76  ?  453  LEU B CG  1 
ATOM   5107 C CD1 . LEU C 1 230 ? -8.853  -16.837 31.136  1.00 8.70  ?  453  LEU B CD1 1 
ATOM   5108 C CD2 . LEU C 1 230 ? -6.302  -17.270 30.969  1.00 8.65  ?  453  LEU B CD2 1 
ATOM   5109 N N   . PRO C 1 231 ? -6.936  -22.135 29.555  1.00 6.02  ?  454  PRO B N   1 
ATOM   5110 C CA  . PRO C 1 231 ? -7.557  -23.464 29.736  1.00 6.97  ?  454  PRO B CA  1 
ATOM   5111 C C   . PRO C 1 231 ? -8.884  -23.340 30.476  1.00 8.06  ?  454  PRO B C   1 
ATOM   5112 O O   . PRO C 1 231 ? -9.091  -22.478 31.350  1.00 6.64  ?  454  PRO B O   1 
ATOM   5113 C CB  . PRO C 1 231 ? -6.545  -24.246 30.576  1.00 8.30  ?  454  PRO B CB  1 
ATOM   5114 C CG  . PRO C 1 231 ? -5.198  -23.489 30.354  1.00 7.18  ?  454  PRO B CG  1 
ATOM   5115 C CD  . PRO C 1 231 ? -5.633  -22.031 30.245  1.00 8.69  ?  454  PRO B CD  1 
ATOM   5116 N N   . GLN C 1 232 ? -9.825  -24.233 30.111  1.00 5.85  ?  455  GLN B N   1 
ATOM   5117 C CA  . GLN C 1 232 ? -11.080 -24.250 30.861  1.00 6.12  ?  455  GLN B CA  1 
ATOM   5118 C C   . GLN C 1 232 ? -10.820 -24.428 32.356  1.00 7.95  ?  455  GLN B C   1 
ATOM   5119 O O   . GLN C 1 232 ? -11.516 -23.814 33.180  1.00 7.94  ?  455  GLN B O   1 
ATOM   5120 C CB  . GLN C 1 232 ? -11.975 -25.385 30.356  1.00 7.68  ?  455  GLN B CB  1 
ATOM   5121 C CG  . GLN C 1 232 ? -13.387 -25.348 31.006  1.00 7.73  ?  455  GLN B CG  1 
ATOM   5122 C CD  . GLN C 1 232 ? -14.160 -24.059 30.732  1.00 8.14  ?  455  GLN B CD  1 
ATOM   5123 O OE1 . GLN C 1 232 ? -13.923 -23.353 29.753  1.00 8.03  ?  455  GLN B OE1 1 
ATOM   5124 N NE2 . GLN C 1 232 ? -15.193 -23.799 31.567  1.00 8.07  ?  455  GLN B NE2 1 
ATOM   5125 N N   . GLU C 1 233 ? -9.790  -25.188 32.734  1.00 7.57  ?  456  GLU B N   1 
ATOM   5126 C CA  . GLU C 1 233 ? -9.528  -25.389 34.157  1.00 7.29  ?  456  GLU B CA  1 
ATOM   5127 C C   . GLU C 1 233 ? -9.085  -24.111 34.840  1.00 8.06  ?  456  GLU B C   1 
ATOM   5128 O O   . GLU C 1 233 ? -9.287  -23.988 36.056  1.00 9.33  ?  456  GLU B O   1 
ATOM   5129 C CB  . GLU C 1 233 ? -8.458  -26.457 34.359  1.00 8.35  ?  456  GLU B CB  1 
ATOM   5130 C CG  . GLU C 1 233 ? -8.992  -27.887 34.111  1.00 7.62  ?  456  GLU B CG  1 
ATOM   5131 C CD  . GLU C 1 233 ? -9.144  -28.281 32.634  1.00 7.19  ?  456  GLU B CD  1 
ATOM   5132 O OE1 . GLU C 1 233 ? -8.713  -27.528 31.760  1.00 7.54  ?  456  GLU B OE1 1 
ATOM   5133 O OE2 . GLU C 1 233 ? -9.718  -29.385 32.390  1.00 8.43  -1 456  GLU B OE2 1 
ATOM   5134 N N   . TRP C 1 234 ? -8.408  -23.198 34.115  1.00 7.54  ?  457  TRP B N   1 
ATOM   5135 C CA  . TRP C 1 234 ? -8.056  -21.908 34.722  1.00 9.37  ?  457  TRP B CA  1 
ATOM   5136 C C   . TRP C 1 234 ? -9.296  -21.055 34.955  1.00 8.67  ?  457  TRP B C   1 
ATOM   5137 O O   . TRP C 1 234 ? -9.410  -20.397 35.995  1.00 8.83  ?  457  TRP B O   1 
ATOM   5138 C CB  . TRP C 1 234 ? -7.023  -21.174 33.873  1.00 8.21  ?  457  TRP B CB  1 
ATOM   5139 C CG  . TRP C 1 234 ? -5.647  -21.826 33.923  1.00 8.66  ?  457  TRP B CG  1 
ATOM   5140 C CD1 . TRP C 1 234 ? -5.314  -23.118 34.299  1.00 7.86  ?  457  TRP B CD1 1 
ATOM   5141 C CD2 . TRP C 1 234 ? -4.411  -21.192 33.579  1.00 7.79  ?  457  TRP B CD2 1 
ATOM   5142 N NE1 . TRP C 1 234 ? -3.935  -23.319 34.171  1.00 8.87  ?  457  TRP B NE1 1 
ATOM   5143 C CE2 . TRP C 1 234 ? -3.369  -22.155 33.736  1.00 8.32  ?  457  TRP B CE2 1 
ATOM   5144 C CE3 . TRP C 1 234 ? -4.076  -19.910 33.132  1.00 7.85  ?  457  TRP B CE3 1 
ATOM   5145 C CZ2 . TRP C 1 234 ? -2.026  -21.871 33.474  1.00 8.49  ?  457  TRP B CZ2 1 
ATOM   5146 C CZ3 . TRP C 1 234 ? -2.695  -19.623 32.837  1.00 9.48  ?  457  TRP B CZ3 1 
ATOM   5147 C CH2 . TRP C 1 234 ? -1.691  -20.614 33.021  1.00 8.68  ?  457  TRP B CH2 1 
ATOM   5148 N N   . VAL C 1 235 ? -10.230 -21.031 33.990  1.00 7.07  ?  458  VAL B N   1 
ATOM   5149 C CA  . VAL C 1 235 ? -11.532 -20.388 34.220  1.00 7.64  ?  458  VAL B CA  1 
ATOM   5150 C C   . VAL C 1 235 ? -12.161 -20.944 35.491  1.00 10.06 ?  458  VAL B C   1 
ATOM   5151 O O   . VAL C 1 235 ? -12.600 -20.191 36.373  1.00 10.95 ?  458  VAL B O   1 
ATOM   5152 C CB  . VAL C 1 235 ? -12.452 -20.599 33.005  1.00 8.91  ?  458  VAL B CB  1 
ATOM   5153 C CG1 . VAL C 1 235 ? -13.886 -20.094 33.328  1.00 10.98 ?  458  VAL B CG1 1 
ATOM   5154 C CG2 . VAL C 1 235 ? -11.854 -19.941 31.726  1.00 9.13  ?  458  VAL B CG2 1 
ATOM   5155 N N   . GLN C 1 236 ? -12.221 -22.283 35.601  1.00 8.17  ?  459  GLN B N   1 
ATOM   5156 C CA  . GLN C 1 236 ? -12.882 -22.886 36.768  1.00 9.31  ?  459  GLN B CA  1 
ATOM   5157 C C   . GLN C 1 236 ? -12.174 -22.498 38.056  1.00 10.17 ?  459  GLN B C   1 
ATOM   5158 O O   . GLN C 1 236 ? -12.819 -22.233 39.079  1.00 11.63 ?  459  GLN B O   1 
ATOM   5159 C CB  . GLN C 1 236 ? -12.905 -24.417 36.596  1.00 8.64  ?  459  GLN B CB  1 
ATOM   5160 C CG  . GLN C 1 236 ? -13.769 -24.849 35.378  1.00 10.04 ?  459  GLN B CG  1 
ATOM   5161 C CD  . GLN C 1 236 ? -13.685 -26.363 35.168  1.00 10.27 ?  459  GLN B CD  1 
ATOM   5162 O OE1 . GLN C 1 236 ? -12.597 -26.944 35.246  1.00 12.13 ?  459  GLN B OE1 1 
ATOM   5163 N NE2 . GLN C 1 236 ? -14.822 -26.994 34.958  1.00 9.65  ?  459  GLN B NE2 1 
ATOM   5164 N N   . TYR C 1 237 ? -10.843 -22.453 38.018  1.00 9.06  ?  460  TYR B N   1 
ATOM   5165 C CA  . TYR C 1 237 ? -10.037 -22.231 39.212  1.00 10.60 ?  460  TYR B CA  1 
ATOM   5166 C C   . TYR C 1 237 ? -10.152 -20.788 39.676  1.00 9.83  ?  460  TYR B C   1 
ATOM   5167 O O   . TYR C 1 237 ? -10.337 -20.532 40.881  1.00 10.95 ?  460  TYR B O   1 
ATOM   5168 C CB  . TYR C 1 237 ? -8.600  -22.584 38.881  1.00 10.34 ?  460  TYR B CB  1 
ATOM   5169 C CG  . TYR C 1 237 ? -7.671  -22.604 40.071  1.00 11.45 ?  460  TYR B CG  1 
ATOM   5170 C CD1 . TYR C 1 237 ? -7.737  -23.617 40.996  1.00 11.63 ?  460  TYR B CD1 1 
ATOM   5171 C CD2 . TYR C 1 237 ? -6.732  -21.586 40.248  1.00 11.38 ?  460  TYR B CD2 1 
ATOM   5172 C CE1 . TYR C 1 237 ? -6.847  -23.680 42.098  1.00 15.69 ?  460  TYR B CE1 1 
ATOM   5173 C CE2 . TYR C 1 237 ? -5.822  -21.632 41.340  1.00 12.41 ?  460  TYR B CE2 1 
ATOM   5174 C CZ  . TYR C 1 237 ? -5.911  -22.677 42.269  1.00 14.30 ?  460  TYR B CZ  1 
ATOM   5175 O OH  . TYR C 1 237 ? -5.017  -22.749 43.357  1.00 16.52 ?  460  TYR B OH  1 
ATOM   5176 N N   . PHE C 1 238 ? -10.037 -19.835 38.746  1.00 10.78 ?  461  PHE B N   1 
ATOM   5177 C CA  . PHE C 1 238 ? -10.152 -18.423 39.122  1.00 10.85 ?  461  PHE B CA  1 
ATOM   5178 C C   . PHE C 1 238 ? -11.562 -18.119 39.618  1.00 11.49 ?  461  PHE B C   1 
ATOM   5179 O O   . PHE C 1 238 ? -11.743 -17.359 40.578  1.00 12.49 ?  461  PHE B O   1 
ATOM   5180 C CB  . PHE C 1 238 ? -9.806  -17.501 37.947  1.00 10.65 ?  461  PHE B CB  1 
ATOM   5181 C CG  . PHE C 1 238 ? -8.415  -17.722 37.381  1.00 9.68  ?  461  PHE B CG  1 
ATOM   5182 C CD1 . PHE C 1 238 ? -7.363  -18.278 38.154  1.00 11.02 ?  461  PHE B CD1 1 
ATOM   5183 C CD2 . PHE C 1 238 ? -8.160  -17.374 36.053  1.00 10.01 ?  461  PHE B CD2 1 
ATOM   5184 C CE1 . PHE C 1 238 ? -6.090  -18.465 37.606  1.00 10.40 ?  461  PHE B CE1 1 
ATOM   5185 C CE2 . PHE C 1 238 ? -6.870  -17.580 35.501  1.00 9.69  ?  461  PHE B CE2 1 
ATOM   5186 C CZ  . PHE C 1 238 ? -5.856  -18.142 36.256  1.00 10.82 ?  461  PHE B CZ  1 
ATOM   5187 N N   . TYR C 1 239 ? -12.580 -18.732 39.014  1.00 10.92 ?  462  TYR B N   1 
ATOM   5188 C CA  . TYR C 1 239 ? -13.933 -18.541 39.526  1.00 12.24 ?  462  TYR B CA  1 
ATOM   5189 C C   . TYR C 1 239 ? -14.040 -19.028 40.966  1.00 14.47 ?  462  TYR B C   1 
ATOM   5190 O O   . TYR C 1 239 ? -14.627 -18.347 41.828  1.00 13.93 ?  462  TYR B O   1 
ATOM   5191 C CB  . TYR C 1 239 ? -14.919 -19.268 38.605  1.00 11.22 ?  462  TYR B CB  1 
ATOM   5192 C CG  . TYR C 1 239 ? -16.344 -19.222 39.093  1.00 12.76 ?  462  TYR B CG  1 
ATOM   5193 C CD1 . TYR C 1 239 ? -17.183 -18.172 38.734  1.00 15.67 ?  462  TYR B CD1 1 
ATOM   5194 C CD2 . TYR C 1 239 ? -16.827 -20.245 39.904  1.00 14.28 ?  462  TYR B CD2 1 
ATOM   5195 C CE1 . TYR C 1 239 ? -18.510 -18.135 39.204  1.00 16.48 ?  462  TYR B CE1 1 
ATOM   5196 C CE2 . TYR C 1 239 ? -18.136 -20.213 40.394  1.00 15.65 ?  462  TYR B CE2 1 
ATOM   5197 C CZ  . TYR C 1 239 ? -18.966 -19.168 40.020  1.00 16.15 ?  462  TYR B CZ  1 
ATOM   5198 O OH  . TYR C 1 239 ? -20.288 -19.132 40.494  1.00 20.46 ?  462  TYR B OH  1 
ATOM   5199 N N   . GLN C 1 240 ? -13.434 -20.163 41.269  1.00 11.17 ?  463  GLN B N   1 
ATOM   5200 C CA  . GLN C 1 240 ? -13.510 -20.718 42.617  1.00 13.97 ?  463  GLN B CA  1 
ATOM   5201 C C   . GLN C 1 240 ? -12.663 -19.929 43.621  1.00 14.43 ?  463  GLN B C   1 
ATOM   5202 O O   . GLN C 1 240 ? -13.106 -19.662 44.755  1.00 13.97 ?  463  GLN B O   1 
ATOM   5203 C CB  . GLN C 1 240 ? -13.054 -22.169 42.557  1.00 15.34 ?  463  GLN B CB  1 
ATOM   5204 C CG  . GLN C 1 240 ? -13.616 -23.108 43.626  1.00 23.46 ?  463  GLN B CG  1 
ATOM   5205 C CD  . GLN C 1 240 ? -15.158 -23.101 43.837  1.00 22.57 ?  463  GLN B CD  1 
ATOM   5206 O OE1 . GLN C 1 240 ? -15.598 -23.146 44.993  1.00 22.50 ?  463  GLN B OE1 1 
ATOM   5207 N NE2 . GLN C 1 240 ? -15.969 -23.124 42.740  1.00 20.05 ?  463  GLN B NE2 1 
ATOM   5208 N N   . GLU C 1 241 ? -11.442 -19.571 43.239  1.00 14.74 ?  464  GLU B N   1 
ATOM   5209 C CA  . GLU C 1 241 ? -10.522 -18.915 44.170  1.00 12.91 ?  464  GLU B CA  1 
ATOM   5210 C C   . GLU C 1 241 ? -10.874 -17.451 44.392  1.00 15.92 ?  464  GLU B C   1 
ATOM   5211 O O   . GLU C 1 241 ? -10.787 -16.953 45.527  1.00 16.67 ?  464  GLU B O   1 
ATOM   5212 C CB  . GLU C 1 241 ? -9.078  -18.977 43.642  1.00 13.57 ?  464  GLU B CB  1 
ATOM   5213 C CG  . GLU C 1 241 ? -8.529  -20.384 43.638  1.00 16.53 ?  464  GLU B CG  1 
ATOM   5214 C CD  . GLU C 1 241 ? -8.213  -20.838 45.049  1.00 22.40 ?  464  GLU B CD  1 
ATOM   5215 O OE1 . GLU C 1 241 ? -7.238  -20.313 45.635  1.00 21.23 ?  464  GLU B OE1 1 
ATOM   5216 O OE2 . GLU C 1 241 ? -8.952  -21.695 45.571  1.00 22.69 -1 464  GLU B OE2 1 
ATOM   5217 N N   . ALA C 1 242 ? -11.196 -16.729 43.335  1.00 13.28 ?  465  ALA B N   1 
ATOM   5218 C CA  . ALA C 1 242 ? -11.502 -15.299 43.421  1.00 13.36 ?  465  ALA B CA  1 
ATOM   5219 C C   . ALA C 1 242 ? -10.441 -14.535 44.208  1.00 14.73 ?  465  ALA B C   1 
ATOM   5220 O O   . ALA C 1 242 ? -10.758 -13.643 45.020  1.00 16.61 ?  465  ALA B O   1 
ATOM   5221 C CB  . ALA C 1 242 ? -12.894 -15.086 44.010  1.00 15.70 ?  465  ALA B CB  1 
ATOM   5222 N N   . ALA C 1 243 ? -9.164  -14.856 43.949  1.00 11.94 ?  466  ALA B N   1 
ATOM   5223 C CA  . ALA C 1 243 ? -8.054  -14.164 44.640  1.00 13.48 ?  466  ALA B CA  1 
ATOM   5224 C C   . ALA C 1 243 ? -7.864  -12.771 44.047  1.00 17.11 ?  466  ALA B C   1 
ATOM   5225 O O   . ALA C 1 243 ? -7.853  -12.616 42.822  1.00 14.23 ?  466  ALA B O   1 
ATOM   5226 C CB  . ALA C 1 243 ? -6.743  -14.958 44.526  1.00 15.68 ?  466  ALA B CB  1 
ATOM   5227 N N   . PRO C 1 244 ? -7.708  -11.732 44.878  1.00 16.35 ?  467  PRO B N   1 
ATOM   5228 C CA  . PRO C 1 244 ? -7.566  -10.376 44.356  1.00 15.46 ?  467  PRO B CA  1 
ATOM   5229 C C   . PRO C 1 244 ? -6.262  -10.207 43.607  1.00 15.80 ?  467  PRO B C   1 
ATOM   5230 O O   . PRO C 1 244 ? -5.233  -10.785 43.977  1.00 17.37 ?  467  PRO B O   1 
ATOM   5231 C CB  . PRO C 1 244 ? -7.576  -9.508  45.634  1.00 19.04 ?  467  PRO B CB  1 
ATOM   5232 C CG  . PRO C 1 244 ? -8.215  -10.381 46.686  1.00 24.49 ?  467  PRO B CG  1 
ATOM   5233 C CD  . PRO C 1 244 ? -7.793  -11.781 46.351  1.00 19.76 ?  467  PRO B CD  1 
ATOM   5234 N N   . ALA C 1 245 ? -6.314  -9.403  42.549  1.00 14.65 ?  468  ALA B N   1 
ATOM   5235 C CA  . ALA C 1 245 ? -5.133  -9.104  41.743  1.00 14.95 ?  468  ALA B CA  1 
ATOM   5236 C C   . ALA C 1 245 ? -4.387  -7.933  42.369  1.00 16.84 ?  468  ALA B C   1 
ATOM   5237 O O   . ALA C 1 245 ? -4.984  -6.876  42.606  1.00 19.20 ?  468  ALA B O   1 
ATOM   5238 C CB  . ALA C 1 245 ? -5.533  -8.773  40.308  1.00 16.06 ?  468  ALA B CB  1 
ATOM   5239 N N   . GLN C 1 246 ? -3.099  -8.115  42.631  1.00 17.49 ?  469  GLN B N   1 
ATOM   5240 C CA  . GLN C 1 246 ? -2.316  -7.068  43.294  1.00 16.08 ?  469  GLN B CA  1 
ATOM   5241 C C   . GLN C 1 246 ? -1.672  -6.114  42.287  1.00 18.20 ?  469  GLN B C   1 
ATOM   5242 O O   . GLN C 1 246 ? -1.112  -5.083  42.688  1.00 17.88 ?  469  GLN B O   1 
ATOM   5243 C CB  . GLN C 1 246 ? -1.227  -7.721  44.157  1.00 17.16 ?  469  GLN B CB  1 
ATOM   5244 C CG  . GLN C 1 246 ? -1.708  -8.520  45.395  1.00 22.50 ?  469  GLN B CG  1 
ATOM   5245 C CD  . GLN C 1 246 ? -2.807  -7.865  46.204  1.00 29.11 ?  469  GLN B CD  1 
ATOM   5246 O OE1 . GLN C 1 246 ? -3.733  -8.545  46.670  1.00 35.17 ?  469  GLN B OE1 1 
ATOM   5247 N NE2 . GLN C 1 246 ? -2.664  -6.562  46.471  1.00 34.16 ?  469  GLN B NE2 1 
ATOM   5248 N N   . SER C 1 247 ? -1.712  -6.449  40.992  1.00 15.06 ?  470  SER B N   1 
ATOM   5249 C CA  . SER C 1 247 ? -1.310  -5.578  39.889  1.00 12.43 ?  470  SER B CA  1 
ATOM   5250 C C   . SER C 1 247 ? -2.078  -6.060  38.673  1.00 17.42 ?  470  SER B C   1 
ATOM   5251 O O   . SER C 1 247 ? -2.947  -6.929  38.798  1.00 17.64 ?  470  SER B O   1 
ATOM   5252 C CB  . SER C 1 247 ? 0.205   -5.579  39.629  1.00 15.17 ?  470  SER B CB  1 
ATOM   5253 O OG  . SER C 1 247 ? 0.659   -6.766  38.936  1.00 14.59 ?  470  SER B OG  1 
ATOM   5254 N N   . ASP C 1 248 ? -1.779  -5.492  37.509  1.00 15.45 ?  471  ASP B N   1 
ATOM   5255 C CA  . ASP C 1 248 ? -2.477  -5.956  36.321  1.00 16.05 ?  471  ASP B CA  1 
ATOM   5256 C C   . ASP C 1 248 ? -1.758  -7.105  35.629  1.00 14.02 ?  471  ASP B C   1 
ATOM   5257 O O   . ASP C 1 248 ? -2.277  -7.600  34.618  1.00 13.84 ?  471  ASP B O   1 
ATOM   5258 C CB  . ASP C 1 248 ? -2.664  -4.824  35.338  1.00 15.98 ?  471  ASP B CB  1 
ATOM   5259 C CG  . ASP C 1 248 ? -3.646  -3.779  35.854  1.00 21.82 ?  471  ASP B CG  1 
ATOM   5260 O OD1 . ASP C 1 248 ? -4.631  -4.149  36.494  1.00 23.54 ?  471  ASP B OD1 1 
ATOM   5261 O OD2 . ASP C 1 248 ? -3.390  -2.594  35.646  1.00 30.82 -1 471  ASP B OD2 1 
ATOM   5262 N N   . VAL C 1 249 ? -0.601  -7.553  36.138  1.00 13.03 ?  472  VAL B N   1 
ATOM   5263 C CA  . VAL C 1 249 ? 0.188   -8.578  35.438  1.00 11.27 ?  472  VAL B CA  1 
ATOM   5264 C C   . VAL C 1 249 ? 0.764   -9.552  36.457  1.00 11.98 ?  472  VAL B C   1 
ATOM   5265 O O   . VAL C 1 249 ? 1.581   -9.164  37.317  1.00 12.17 ?  472  VAL B O   1 
ATOM   5266 C CB  . VAL C 1 249 ? 1.325   -7.963  34.591  1.00 11.59 ?  472  VAL B CB  1 
ATOM   5267 C CG1 . VAL C 1 249 ? 2.099   -9.030  33.862  1.00 11.92 ?  472  VAL B CG1 1 
ATOM   5268 C CG2 . VAL C 1 249 ? 0.767   -6.965  33.623  1.00 15.48 ?  472  VAL B CG2 1 
ATOM   5269 N N   . ALA C 1 250 ? 0.402   -10.840 36.320  1.00 11.43 ?  473  ALA B N   1 
ATOM   5270 C CA  . ALA C 1 250 ? 0.940   -11.939 37.118  1.00 11.55 ?  473  ALA B CA  1 
ATOM   5271 C C   . ALA C 1 250 ? 2.053   -12.626 36.332  1.00 11.85 ?  473  ALA B C   1 
ATOM   5272 O O   . ALA C 1 250 ? 1.842   -13.050 35.181  1.00 12.17 ?  473  ALA B O   1 
ATOM   5273 C CB  . ALA C 1 250 ? -0.140  -12.980 37.448  1.00 11.14 ?  473  ALA B CB  1 
ATOM   5274 N N   . LEU C 1 251 ? 3.245   -12.714 36.921  1.00 10.44 ?  474  LEU B N   1 
ATOM   5275 C CA  . LEU C 1 251 ? 4.377   -13.382 36.285  1.00 12.07 ?  474  LEU B CA  1 
ATOM   5276 C C   . LEU C 1 251 ? 4.322   -14.876 36.586  1.00 11.60 ?  474  LEU B C   1 
ATOM   5277 O O   . LEU C 1 251 ? 4.329   -15.281 37.753  1.00 10.78 ?  474  LEU B O   1 
ATOM   5278 C CB  . LEU C 1 251 ? 5.703   -12.778 36.763  1.00 10.90 ?  474  LEU B CB  1 
ATOM   5279 C CG  . LEU C 1 251 ? 6.958   -13.402 36.180  1.00 10.50 ?  474  LEU B CG  1 
ATOM   5280 C CD1 . LEU C 1 251 ? 6.993   -13.202 34.697  1.00 12.42 ?  474  LEU B CD1 1 
ATOM   5281 C CD2 . LEU C 1 251 ? 8.190   -12.718 36.809  1.00 13.07 ?  474  LEU B CD2 1 
ATOM   5282 N N   . LEU C 1 252 ? 4.182   -15.710 35.535  1.00 10.09 ?  475  LEU B N   1 
ATOM   5283 C CA  . LEU C 1 252 ? 4.215   -17.156 35.704  1.00 9.67  ?  475  LEU B CA  1 
ATOM   5284 C C   . LEU C 1 252 ? 5.514   -17.724 35.169  1.00 9.80  ?  475  LEU B C   1 
ATOM   5285 O O   . LEU C 1 252 ? 6.053   -17.225 34.181  1.00 10.17 ?  475  LEU B O   1 
ATOM   5286 C CB  . LEU C 1 252 ? 3.046   -17.830 34.947  1.00 8.42  ?  475  LEU B CB  1 
ATOM   5287 C CG  . LEU C 1 252 ? 1.635   -17.279 35.139  1.00 9.77  ?  475  LEU B CG  1 
ATOM   5288 C CD1 . LEU C 1 252 ? 0.641   -18.232 34.420  1.00 9.07  ?  475  LEU B CD1 1 
ATOM   5289 C CD2 . LEU C 1 252 ? 1.251   -17.147 36.616  1.00 10.46 ?  475  LEU B CD2 1 
ATOM   5290 N N   . ARG C 1 253 ? 5.995   -18.791 35.820  1.00 10.17 ?  476  ARG B N   1 
ATOM   5291 C CA  . ARG C 1 253 ? 7.129   -19.552 35.289  1.00 10.10 ?  476  ARG B CA  1 
ATOM   5292 C C   . ARG C 1 253 ? 6.650   -20.950 34.945  1.00 9.97  ?  476  ARG B C   1 
ATOM   5293 O O   . ARG C 1 253 ? 5.855   -21.535 35.688  1.00 11.89 ?  476  ARG B O   1 
ATOM   5294 C CB  . ARG C 1 253 ? 8.282   -19.646 36.311  1.00 11.77 ?  476  ARG B CB  1 
ATOM   5295 C CG  . ARG C 1 253 ? 9.348   -18.492 36.165  1.00 12.77 ?  476  ARG B CG  1 
ATOM   5296 C CD  . ARG C 1 253 ? 8.688   -17.143 36.433  1.00 12.86 ?  476  ARG B CD  1 
ATOM   5297 N NE  . ARG C 1 253 ? 9.657   -16.049 36.323  1.00 15.16 ?  476  ARG B NE  1 
ATOM   5298 C CZ  . ARG C 1 253 ? 10.393  -15.617 37.340  1.00 17.59 ?  476  ARG B CZ  1 
ATOM   5299 N NH1 . ARG C 1 253 ? 10.237  -16.119 38.558  1.00 15.86 ?  476  ARG B NH1 1 
ATOM   5300 N NH2 . ARG C 1 253 ? 11.309  -14.662 37.120  1.00 19.36 ?  476  ARG B NH2 1 
ATOM   5301 N N   . PHE C 1 254 ? 7.075   -21.458 33.793  1.00 9.61  ?  477  PHE B N   1 
ATOM   5302 C CA  . PHE C 1 254 ? 6.744   -22.832 33.396  1.00 10.71 ?  477  PHE B CA  1 
ATOM   5303 C C   . PHE C 1 254 ? 7.916   -23.710 33.817  1.00 12.21 ?  477  PHE B C   1 
ATOM   5304 O O   . PHE C 1 254 ? 9.044   -23.496 33.352  1.00 12.47 ?  477  PHE B O   1 
ATOM   5305 C CB  . PHE C 1 254 ? 6.479   -22.900 31.886  1.00 10.53 ?  477  PHE B CB  1 
ATOM   5306 C CG  . PHE C 1 254 ? 5.916   -24.209 31.468  1.00 10.97 ?  477  PHE B CG  1 
ATOM   5307 C CD1 . PHE C 1 254 ? 4.566   -24.427 31.494  1.00 10.25 ?  477  PHE B CD1 1 
ATOM   5308 C CD2 . PHE C 1 254 ? 6.773   -25.235 31.084  1.00 11.95 ?  477  PHE B CD2 1 
ATOM   5309 C CE1 . PHE C 1 254 ? 4.044   -25.684 31.132  1.00 9.68  ?  477  PHE B CE1 1 
ATOM   5310 C CE2 . PHE C 1 254 ? 6.275   -26.515 30.725  1.00 11.85 ?  477  PHE B CE2 1 
ATOM   5311 C CZ  . PHE C 1 254 ? 4.916   -26.726 30.734  1.00 9.81  ?  477  PHE B CZ  1 
ATOM   5312 N N   . VAL C 1 255 ? 7.634   -24.689 34.691  1.00 11.92 ?  478  VAL B N   1 
ATOM   5313 C CA  . VAL C 1 255 ? 8.676   -25.417 35.411  1.00 13.23 ?  478  VAL B CA  1 
ATOM   5314 C C   . VAL C 1 255 ? 8.618   -26.902 35.097  1.00 15.31 ?  478  VAL B C   1 
ATOM   5315 O O   . VAL C 1 255 ? 7.541   -27.489 35.001  1.00 14.67 ?  478  VAL B O   1 
ATOM   5316 C CB  . VAL C 1 255 ? 8.485   -25.211 36.923  1.00 15.19 ?  478  VAL B CB  1 
ATOM   5317 C CG1 . VAL C 1 255 ? 9.645   -25.818 37.682  1.00 20.87 ?  478  VAL B CG1 1 
ATOM   5318 C CG2 . VAL C 1 255 ? 8.364   -23.732 37.205  1.00 17.41 ?  478  VAL B CG2 1 
ATOM   5319 N N   . ASN C 1 256 ? 9.789   -27.533 35.076  1.00 15.78 ?  479  ASN B N   1 
ATOM   5320 C CA  . ASN C 1 256 ? 9.878   -28.991 35.027  1.00 16.14 ?  479  ASN B CA  1 
ATOM   5321 C C   . ASN C 1 256 ? 9.999   -29.512 36.456  1.00 20.13 ?  479  ASN B C   1 
ATOM   5322 O O   . ASN C 1 256 ? 11.045  -29.294 37.095  1.00 22.47 ?  479  ASN B O   1 
ATOM   5323 C CB  . ASN C 1 256 ? 11.079  -29.406 34.210  1.00 17.24 ?  479  ASN B CB  1 
ATOM   5324 C CG  . ASN C 1 256 ? 11.208  -30.909 34.103  1.00 22.80 ?  479  ASN B CG  1 
ATOM   5325 O OD1 . ASN C 1 256 ? 10.738  -31.648 34.963  1.00 26.28 ?  479  ASN B OD1 1 
ATOM   5326 N ND2 . ASN C 1 256 ? 11.834  -31.360 33.048  1.00 22.74 ?  479  ASN B ND2 1 
ATOM   5327 N N   . PRO C 1 257 ? 8.975   -30.158 37.011  1.00 20.42 ?  480  PRO B N   1 
ATOM   5328 C CA  . PRO C 1 257 ? 9.019   -30.476 38.444  1.00 21.13 ?  480  PRO B CA  1 
ATOM   5329 C C   . PRO C 1 257 ? 10.096  -31.496 38.793  1.00 26.38 ?  480  PRO B C   1 
ATOM   5330 O O   . PRO C 1 257 ? 10.431  -31.629 39.981  1.00 32.73 ?  480  PRO B O   1 
ATOM   5331 C CB  . PRO C 1 257 ? 7.619   -31.029 38.727  1.00 23.13 ?  480  PRO B CB  1 
ATOM   5332 C CG  . PRO C 1 257 ? 7.195   -31.644 37.407  1.00 18.13 ?  480  PRO B CG  1 
ATOM   5333 C CD  . PRO C 1 257 ? 7.791   -30.735 36.335  1.00 18.48 ?  480  PRO B CD  1 
ATOM   5334 N N   . ASP C 1 258 ? 10.636  -32.230 37.817  1.00 24.02 ?  481  ASP B N   1 
ATOM   5335 C CA  . ASP C 1 258 ? 11.674  -33.206 38.147  1.00 28.96 ?  481  ASP B CA  1 
ATOM   5336 C C   . ASP C 1 258 ? 13.004  -32.537 38.434  1.00 36.25 ?  481  ASP B C   1 
ATOM   5337 O O   . ASP C 1 258 ? 13.749  -32.994 39.310  1.00 38.76 ?  481  ASP B O   1 
ATOM   5338 C CB  . ASP C 1 258 ? 11.874  -34.190 37.018  1.00 30.74 ?  481  ASP B CB  1 
ATOM   5339 C CG  . ASP C 1 258 ? 10.681  -35.035 36.789  1.00 32.11 ?  481  ASP B CG  1 
ATOM   5340 O OD1 . ASP C 1 258 ? 9.989   -35.371 37.792  1.00 33.77 ?  481  ASP B OD1 1 
ATOM   5341 O OD2 . ASP C 1 258 ? 10.418  -35.309 35.602  1.00 33.53 -1 481  ASP B OD2 1 
ATOM   5342 N N   . THR C 1 259 ? 13.349  -31.490 37.670  1.00 30.81 ?  482  THR B N   1 
ATOM   5343 C CA  . THR C 1 259 ? 14.624  -30.798 37.824  1.00 28.70 ?  482  THR B CA  1 
ATOM   5344 C C   . THR C 1 259 ? 14.509  -29.439 38.486  1.00 33.08 ?  482  THR B C   1 
ATOM   5345 O O   . THR C 1 259 ? 15.546  -28.853 38.824  1.00 34.59 ?  482  THR B O   1 
ATOM   5346 C CB  . THR C 1 259 ? 15.295  -30.623 36.460  1.00 31.60 ?  482  THR B CB  1 
ATOM   5347 O OG1 . THR C 1 259 ? 14.433  -29.853 35.618  1.00 30.90 ?  482  THR B OG1 1 
ATOM   5348 C CG2 . THR C 1 259 ? 15.539  -31.963 35.801  1.00 32.09 ?  482  THR B CG2 1 
ATOM   5349 N N   . GLY C 1 260 ? 13.292  -28.928 38.694  1.00 27.07 ?  483  GLY B N   1 
ATOM   5350 C CA  . GLY C 1 260 ? 13.078  -27.578 39.157  1.00 27.82 ?  483  GLY B CA  1 
ATOM   5351 C C   . GLY C 1 260 ? 13.459  -26.524 38.136  1.00 28.88 ?  483  GLY B C   1 
ATOM   5352 O O   . GLY C 1 260 ? 13.319  -25.332 38.413  1.00 32.69 ?  483  GLY B O   1 
ATOM   5353 N N   . ARG C 1 261 ? 13.914  -26.928 36.950  1.00 28.08 ?  484  ARG B N   1 
ATOM   5354 C CA  . ARG C 1 261 ? 14.372  -25.962 35.952  1.00 27.87 ?  484  ARG B CA  1 
ATOM   5355 C C   . ARG C 1 261 ? 13.199  -25.170 35.361  1.00 25.12 ?  484  ARG B C   1 
ATOM   5356 O O   . ARG C 1 261 ? 12.142  -25.731 35.069  1.00 19.47 ?  484  ARG B O   1 
ATOM   5357 C CB  . ARG C 1 261 ? 15.130  -26.671 34.827  1.00 31.63 ?  484  ARG B CB  1 
ATOM   5358 C CG  . ARG C 1 261 ? 16.522  -27.279 35.191  1.00 40.94 ?  484  ARG B CG  1 
ATOM   5359 C CD  . ARG C 1 261 ? 17.466  -26.332 35.993  1.00 47.42 ?  484  ARG B CD  1 
ATOM   5360 N NE  . ARG C 1 261 ? 17.085  -26.156 37.396  1.00 53.94 ?  484  ARG B NE  1 
ATOM   5361 C CZ  . ARG C 1 261 ? 17.124  -25.008 38.070  1.00 59.26 ?  484  ARG B CZ  1 
ATOM   5362 N NH1 . ARG C 1 261 ? 17.488  -23.868 37.491  1.00 59.22 ?  484  ARG B NH1 1 
ATOM   5363 N NH2 . ARG C 1 261 ? 16.793  -25.003 39.362  1.00 55.45 ?  484  ARG B NH2 1 
ATOM   5364 N N   . VAL C 1 262 ? 13.395  -23.860 35.181  1.00 26.34 ?  485  VAL B N   1 
ATOM   5365 C CA  . VAL C 1 262 ? 12.407  -23.002 34.531  1.00 20.30 ?  485  VAL B CA  1 
ATOM   5366 C C   . VAL C 1 262 ? 12.616  -23.063 33.023  1.00 22.04 ?  485  VAL B C   1 
ATOM   5367 O O   . VAL C 1 262 ? 13.708  -22.762 32.515  1.00 22.77 ?  485  VAL B O   1 
ATOM   5368 C CB  . VAL C 1 262 ? 12.495  -21.558 35.057  1.00 20.17 ?  485  VAL B CB  1 
ATOM   5369 C CG1 . VAL C 1 262 ? 11.620  -20.575 34.168  1.00 19.52 ?  485  VAL B CG1 1 
ATOM   5370 C CG2 . VAL C 1 262 ? 12.099  -21.484 36.500  1.00 21.27 ?  485  VAL B CG2 1 
ATOM   5371 N N   . LEU C 1 263 ? 11.579  -23.466 32.282  1.00 14.52 ?  486  LEU B N   1 
ATOM   5372 C CA  . LEU C 1 263 ? 11.712  -23.502 30.826  1.00 17.37 ?  486  LEU B CA  1 
ATOM   5373 C C   . LEU C 1 263 ? 11.517  -22.116 30.221  1.00 20.11 ?  486  LEU B C   1 
ATOM   5374 O O   . LEU C 1 263 ? 12.238  -21.718 29.289  1.00 23.42 ?  486  LEU B O   1 
ATOM   5375 C CB  . LEU C 1 263 ? 10.709  -24.480 30.172  1.00 17.55 ?  486  LEU B CB  1 
ATOM   5376 C CG  . LEU C 1 263 ? 10.894  -25.993 30.024  1.00 24.47 ?  486  LEU B CG  1 
ATOM   5377 C CD1 . LEU C 1 263 ? 12.294  -26.285 29.503  1.00 27.27 ?  486  LEU B CD1 1 
ATOM   5378 C CD2 . LEU C 1 263 ? 10.675  -26.654 31.401  1.00 23.53 ?  486  LEU B CD2 1 
ATOM   5379 N N   . PHE C 1 264 ? 10.514  -21.390 30.699  1.00 13.08 ?  487  PHE B N   1 
ATOM   5380 C CA  . PHE C 1 264 ? 10.263  -20.041 30.206  1.00 12.04 ?  487  PHE B CA  1 
ATOM   5381 C C   . PHE C 1 264 ? 9.380   -19.325 31.209  1.00 11.60 ?  487  PHE B C   1 
ATOM   5382 O O   . PHE C 1 264 ? 8.832   -19.941 32.141  1.00 10.87 ?  487  PHE B O   1 
ATOM   5383 C CB  . PHE C 1 264 ? 9.611   -20.036 28.802  1.00 13.85 ?  487  PHE B CB  1 
ATOM   5384 C CG  . PHE C 1 264 ? 8.209   -20.653 28.753  1.00 11.22 ?  487  PHE B CG  1 
ATOM   5385 C CD1 . PHE C 1 264 ? 8.033   -22.022 28.529  1.00 11.74 ?  487  PHE B CD1 1 
ATOM   5386 C CD2 . PHE C 1 264 ? 7.087   -19.862 28.901  1.00 11.56 ?  487  PHE B CD2 1 
ATOM   5387 C CE1 . PHE C 1 264 ? 6.711   -22.576 28.506  1.00 10.90 ?  487  PHE B CE1 1 
ATOM   5388 C CE2 . PHE C 1 264 ? 5.786   -20.394 28.860  1.00 11.40 ?  487  PHE B CE2 1 
ATOM   5389 C CZ  . PHE C 1 264 ? 5.599   -21.760 28.700  1.00 10.01 ?  487  PHE B CZ  1 
ATOM   5390 N N   . GLU C 1 265 ? 9.239   -18.008 30.991  1.00 11.27 ?  488  GLU B N   1 
ATOM   5391 C CA  . GLU C 1 265 ? 8.277   -17.244 31.785  1.00 10.22 ?  488  GLU B CA  1 
ATOM   5392 C C   . GLU C 1 265 ? 7.279   -16.515 30.887  1.00 9.27  ?  488  GLU B C   1 
ATOM   5393 O O   . GLU C 1 265 ? 7.467   -16.370 29.663  1.00 9.79  ?  488  GLU B O   1 
ATOM   5394 C CB  . GLU C 1 265 ? 8.974   -16.226 32.749  1.00 12.46 ?  488  GLU B CB  1 
ATOM   5395 C CG  . GLU C 1 265 ? 9.759   -15.163 32.038  1.00 12.71 ?  488  GLU B CG  1 
ATOM   5396 C CD  . GLU C 1 265 ? 10.449  -14.192 33.011  1.00 15.56 ?  488  GLU B CD  1 
ATOM   5397 O OE1 . GLU C 1 265 ? 10.836  -14.628 34.108  1.00 16.10 ?  488  GLU B OE1 1 
ATOM   5398 O OE2 . GLU C 1 265 ? 10.565  -13.002 32.648  1.00 13.29 -1 488  GLU B OE2 1 
ATOM   5399 N N   . CYS C 1 266 ? 6.163   -16.110 31.488  1.00 8.00  ?  489  CYS B N   1 
ATOM   5400 C CA  . CYS C 1 266 ? 5.083   -15.488 30.709  1.00 9.22  ?  489  CYS B CA  1 
ATOM   5401 C C   . CYS C 1 266 ? 4.267   -14.564 31.603  1.00 9.27  ?  489  CYS B C   1 
ATOM   5402 O O   . CYS C 1 266 ? 4.283   -14.678 32.845  1.00 8.96  ?  489  CYS B O   1 
ATOM   5403 C CB  . CYS C 1 266 ? 4.164   -16.555 30.035  1.00 8.92  ?  489  CYS B CB  1 
ATOM   5404 S SG  . CYS C 1 266 ? 3.290   -17.623 31.183  1.00 9.71  ?  489  CYS B SG  1 
ATOM   5405 N N   . LYS C 1 267 ? 3.570   -13.625 30.958  1.00 7.79  ?  490  LYS B N   1 
ATOM   5406 C CA  . LYS C 1 267 ? 2.658   -12.702 31.637  1.00 8.01  ?  490  LYS B CA  1 
ATOM   5407 C C   . LYS C 1 267 ? 1.233   -13.233 31.574  1.00 8.72  ?  490  LYS B C   1 
ATOM   5408 O O   . LYS C 1 267 ? 0.685   -13.394 30.472  1.00 9.97  ?  490  LYS B O   1 
ATOM   5409 C CB  . LYS C 1 267 ? 2.630   -11.324 30.961  1.00 7.22  ?  490  LYS B CB  1 
ATOM   5410 C CG  . LYS C 1 267 ? 3.904   -10.504 31.226  1.00 9.53  ?  490  LYS B CG  1 
ATOM   5411 C CD  . LYS C 1 267 ? 3.811   -9.228  30.422  1.00 9.48  ?  490  LYS B CD  1 
ATOM   5412 C CE  . LYS C 1 267 ? 5.001   -8.312  30.771  1.00 13.57 ?  490  LYS B CE  1 
ATOM   5413 N NZ  . LYS C 1 267 ? 4.927   -7.127  29.868  1.00 11.99 ?  490  LYS B NZ  1 
ATOM   5414 N N   . LEU C 1 268 ? 0.602   -13.407 32.735  1.00 7.93  ?  491  LEU B N   1 
ATOM   5415 C CA  . LEU C 1 268 ? -0.842  -13.669 32.777  1.00 10.04 ?  491  LEU B CA  1 
ATOM   5416 C C   . LEU C 1 268 ? -1.487  -12.344 33.171  1.00 10.11 ?  491  LEU B C   1 
ATOM   5417 O O   . LEU C 1 268 ? -1.413  -11.924 34.330  1.00 9.67  ?  491  LEU B O   1 
ATOM   5418 C CB  . LEU C 1 268 ? -1.175  -14.808 33.749  1.00 9.36  ?  491  LEU B CB  1 
ATOM   5419 C CG  . LEU C 1 268 ? -2.669  -14.918 34.105  1.00 9.42  ?  491  LEU B CG  1 
ATOM   5420 C CD1 . LEU C 1 268 ? -3.522  -15.229 32.845  1.00 7.46  ?  491  LEU B CD1 1 
ATOM   5421 C CD2 . LEU C 1 268 ? -2.878  -16.029 35.170  1.00 9.79  ?  491  LEU B CD2 1 
ATOM   5422 N N   . HIS C 1 269 ? -2.181  -11.741 32.231  1.00 7.30  ?  492  HIS B N   1 
ATOM   5423 C CA  . HIS C 1 269 ? -2.811  -10.439 32.448  1.00 8.85  ?  492  HIS B CA  1 
ATOM   5424 C C   . HIS C 1 269 ? -4.075  -10.590 33.272  1.00 10.32 ?  492  HIS B C   1 
ATOM   5425 O O   . HIS C 1 269 ? -4.807  -11.586 33.151  1.00 10.14 ?  492  HIS B O   1 
ATOM   5426 C CB  . HIS C 1 269 ? -3.119  -9.817  31.090  1.00 10.40 ?  492  HIS B CB  1 
ATOM   5427 C CG  . HIS C 1 269 ? -1.887  -9.602  30.282  1.00 11.84 ?  492  HIS B CG  1 
ATOM   5428 N ND1 . HIS C 1 269 ? -1.242  -8.382  30.247  1.00 12.80 ?  492  HIS B ND1 1 
ATOM   5429 C CD2 . HIS C 1 269 ? -1.145  -10.451 29.523  1.00 11.31 ?  492  HIS B CD2 1 
ATOM   5430 C CE1 . HIS C 1 269 ? -0.159  -8.480  29.488  1.00 12.78 ?  492  HIS B CE1 1 
ATOM   5431 N NE2 . HIS C 1 269 ? -0.064  -9.738  29.054  1.00 11.12 ?  492  HIS B NE2 1 
ATOM   5432 N N   . LYS C 1 270 ? -4.326  -9.612  34.166  1.00 9.00  ?  493  LYS B N   1 
ATOM   5433 C CA  . LYS C 1 270 ? -5.491  -9.682  35.052  1.00 8.49  ?  493  LYS B CA  1 
ATOM   5434 C C   . LYS C 1 270 ? -6.779  -9.890  34.280  1.00 10.30 ?  493  LYS B C   1 
ATOM   5435 O O   . LYS C 1 270 ? -7.690  -10.551 34.770  1.00 11.67 ?  493  LYS B O   1 
ATOM   5436 C CB  . LYS C 1 270 ? -5.576  -8.387  35.931  1.00 12.85 ?  493  LYS B CB  1 
ATOM   5437 C CG  . LYS C 1 270 ? -6.896  -8.169  36.656  1.00 17.50 ?  493  LYS B CG  1 
ATOM   5438 C CD  . LYS C 1 270 ? -6.876  -6.811  37.421  1.00 17.82 ?  493  LYS B CD  1 
ATOM   5439 C CE  . LYS C 1 270 ? -8.146  -6.701  38.263  1.00 22.48 ?  493  LYS B CE  1 
ATOM   5440 N NZ  . LYS C 1 270 ? -8.336  -5.315  38.842  1.00 29.30 ?  493  LYS B NZ  1 
ATOM   5441 N N   . SER C 1 271 ? -6.875  -9.332  33.064  1.00 9.51  ?  494  SER B N   1 
ATOM   5442 C CA  . SER C 1 271 ? -8.117  -9.458  32.315  1.00 9.34  ?  494  SER B CA  1 
ATOM   5443 C C   . SER C 1 271 ? -8.224  -10.804 31.584  1.00 9.63  ?  494  SER B C   1 
ATOM   5444 O O   . SER C 1 271 ? -9.258  -11.066 30.962  1.00 10.90 ?  494  SER B O   1 
ATOM   5445 C CB  . SER C 1 271 ? -8.246  -8.290  31.318  1.00 10.49 ?  494  SER B CB  1 
ATOM   5446 O OG  . SER C 1 271 ? -7.170  -8.230  30.367  1.00 12.43 ?  494  SER B OG  1 
ATOM   5447 N N   . GLY C 1 272 ? -7.217  -11.664 31.693  1.00 9.05  ?  495  GLY B N   1 
ATOM   5448 C CA  . GLY C 1 272 ? -7.394  -13.073 31.346  1.00 9.45  ?  495  GLY B CA  1 
ATOM   5449 C C   . GLY C 1 272 ? -6.832  -13.506 30.004  1.00 8.08  ?  495  GLY B C   1 
ATOM   5450 O O   . GLY C 1 272 ? -7.564  -14.039 29.181  1.00 8.28  ?  495  GLY B O   1 
ATOM   5451 N N   . TYR C 1 273 ? -5.542  -13.302 29.775  1.00 7.36  ?  496  TYR B N   1 
ATOM   5452 C CA  . TYR C 1 273 ? -4.843  -13.820 28.599  1.00 8.41  ?  496  TYR B CA  1 
ATOM   5453 C C   . TYR C 1 273 ? -3.356  -13.774 28.902  1.00 9.22  ?  496  TYR B C   1 
ATOM   5454 O O   . TYR C 1 273 ? -2.931  -13.200 29.919  1.00 9.19  ?  496  TYR B O   1 
ATOM   5455 C CB  . TYR C 1 273 ? -5.185  -13.022 27.336  1.00 7.91  ?  496  TYR B CB  1 
ATOM   5456 C CG  . TYR C 1 273 ? -4.660  -11.586 27.347  1.00 6.95  ?  496  TYR B CG  1 
ATOM   5457 C CD1 . TYR C 1 273 ? -5.394  -10.579 27.979  1.00 8.94  ?  496  TYR B CD1 1 
ATOM   5458 C CD2 . TYR C 1 273 ? -3.469  -11.246 26.706  1.00 8.92  ?  496  TYR B CD2 1 
ATOM   5459 C CE1 . TYR C 1 273 ? -4.954  -9.266  27.958  1.00 10.55 ?  496  TYR B CE1 1 
ATOM   5460 C CE2 . TYR C 1 273 ? -2.995  -9.917  26.680  1.00 11.45 ?  496  TYR B CE2 1 
ATOM   5461 C CZ  . TYR C 1 273 ? -3.730  -8.953  27.326  1.00 11.54 ?  496  TYR B CZ  1 
ATOM   5462 O OH  . TYR C 1 273 ? -3.249  -7.643  27.309  1.00 13.69 ?  496  TYR B OH  1 
ATOM   5463 N N   . VAL C 1 274 ? -2.561  -14.426 28.046  1.00 6.90  ?  497  VAL B N   1 
ATOM   5464 C CA  . VAL C 1 274 ? -1.144  -14.671 28.355  1.00 7.23  ?  497  VAL B CA  1 
ATOM   5465 C C   . VAL C 1 274 ? -0.273  -14.160 27.229  1.00 8.85  ?  497  VAL B C   1 
ATOM   5466 O O   . VAL C 1 274 ? -0.605  -14.326 26.051  1.00 7.67  ?  497  VAL B O   1 
ATOM   5467 C CB  . VAL C 1 274 ? -0.884  -16.190 28.558  1.00 5.73  ?  497  VAL B CB  1 
ATOM   5468 C CG1 . VAL C 1 274 ? 0.624   -16.448 28.867  1.00 8.24  ?  497  VAL B CG1 1 
ATOM   5469 C CG2 . VAL C 1 274 ? -1.788  -16.775 29.660  1.00 7.34  ?  497  VAL B CG2 1 
ATOM   5470 N N   . THR C 1 275 ? 0.885   -13.546 27.569  1.00 6.24  ?  498  THR B N   1 
ATOM   5471 C CA  . THR C 1 275 ? 1.842   -13.187 26.539  1.00 7.17  ?  498  THR B CA  1 
ATOM   5472 C C   . THR C 1 275 ? 3.226   -13.711 26.902  1.00 7.04  ?  498  THR B C   1 
ATOM   5473 O O   . THR C 1 275 ? 3.542   -13.975 28.069  1.00 8.29  ?  498  THR B O   1 
ATOM   5474 C CB  . THR C 1 275 ? 1.922   -11.663 26.262  1.00 9.03  ?  498  THR B CB  1 
ATOM   5475 O OG1 . THR C 1 275 ? 2.223   -10.949 27.488  1.00 8.93  ?  498  THR B OG1 1 
ATOM   5476 C CG2 . THR C 1 275 ? 0.581   -11.146 25.662  1.00 9.19  ?  498  THR B CG2 1 
ATOM   5477 N N   . VAL C 1 276 ? 4.054   -13.874 25.861  1.00 7.45  ?  499  VAL B N   1 
ATOM   5478 C CA  . VAL C 1 276 ? 5.430   -14.325 25.982  1.00 6.87  ?  499  VAL B CA  1 
ATOM   5479 C C   . VAL C 1 276 ? 6.313   -13.421 25.142  1.00 7.27  ?  499  VAL B C   1 
ATOM   5480 O O   . VAL C 1 276 ? 5.856   -12.698 24.247  1.00 8.60  ?  499  VAL B O   1 
ATOM   5481 C CB  . VAL C 1 276 ? 5.627   -15.809 25.523  1.00 6.04  ?  499  VAL B CB  1 
ATOM   5482 C CG1 . VAL C 1 276 ? 4.956   -16.718 26.518  1.00 9.07  ?  499  VAL B CG1 1 
ATOM   5483 C CG2 . VAL C 1 276 ? 5.042   -16.001 24.105  1.00 7.70  ?  499  VAL B CG2 1 
ATOM   5484 N N   . ALA C 1 277 ? 7.621   -13.455 25.429  1.00 7.56  ?  500  ALA B N   1 
ATOM   5485 C CA  . ALA C 1 277 ? 8.586   -12.731 24.598  1.00 10.42 ?  500  ALA B CA  1 
ATOM   5486 C C   . ALA C 1 277 ? 9.173   -13.687 23.551  1.00 10.68 ?  500  ALA B C   1 
ATOM   5487 O O   . ALA C 1 277 ? 10.093  -14.462 23.840  1.00 10.86 ?  500  ALA B O   1 
ATOM   5488 C CB  . ALA C 1 277 ? 9.721   -12.152 25.454  1.00 10.74 ?  500  ALA B CB  1 
ATOM   5489 N N   . HIS C 1 278 ? 8.644   -13.610 22.325  1.00 11.79 ?  501  HIS B N   1 
ATOM   5490 C CA  . HIS C 1 278 ? 9.134   -14.415 21.216  1.00 10.81 ?  501  HIS B CA  1 
ATOM   5491 C C   . HIS C 1 278 ? 8.674   -13.736 19.938  1.00 11.21 ?  501  HIS B C   1 
ATOM   5492 O O   . HIS C 1 278 ? 7.597   -13.150 19.904  1.00 11.09 ?  501  HIS B O   1 
ATOM   5493 C CB  . HIS C 1 278 ? 8.591   -15.866 21.292  1.00 9.95  ?  501  HIS B CB  1 
ATOM   5494 C CG  . HIS C 1 278 ? 9.036   -16.734 20.148  1.00 11.10 ?  501  HIS B CG  1 
ATOM   5495 N ND1 . HIS C 1 278 ? 10.355  -17.095 19.966  1.00 13.25 ?  501  HIS B ND1 1 
ATOM   5496 C CD2 . HIS C 1 278 ? 8.338   -17.313 19.133  1.00 13.05 ?  501  HIS B CD2 1 
ATOM   5497 C CE1 . HIS C 1 278 ? 10.453  -17.857 18.885  1.00 12.38 ?  501  HIS B CE1 1 
ATOM   5498 N NE2 . HIS C 1 278 ? 9.247   -17.993 18.348  1.00 13.08 ?  501  HIS B NE2 1 
ATOM   5499 N N   . THR C 1 279 ? 9.472   -13.882 18.866  1.00 11.49 ?  502  THR B N   1 
ATOM   5500 C CA  . THR C 1 279 ? 9.074   -13.456 17.526  1.00 13.28 ?  502  THR B CA  1 
ATOM   5501 C C   . THR C 1 279 ? 9.112   -14.678 16.610  1.00 13.68 ?  502  THR B C   1 
ATOM   5502 O O   . THR C 1 279 ? 10.194  -15.206 16.308  1.00 14.35 ?  502  THR B O   1 
ATOM   5503 C CB  . THR C 1 279 ? 9.999   -12.340 16.993  1.00 14.42 ?  502  THR B CB  1 
ATOM   5504 O OG1 . THR C 1 279 ? 9.949   -11.237 17.908  1.00 16.64 ?  502  THR B OG1 1 
ATOM   5505 C CG2 . THR C 1 279 ? 9.465   -11.841 15.645  1.00 16.20 ?  502  THR B CG2 1 
ATOM   5506 N N   . GLY C 1 280 ? 7.955   -15.156 16.190  1.00 12.69 ?  503  GLY B N   1 
ATOM   5507 C CA  . GLY C 1 280 ? 7.929   -16.312 15.308  1.00 14.05 ?  503  GLY B CA  1 
ATOM   5508 C C   . GLY C 1 280 ? 6.714   -17.176 15.601  1.00 14.12 ?  503  GLY B C   1 
ATOM   5509 O O   . GLY C 1 280 ? 6.026   -17.008 16.604  1.00 11.56 ?  503  GLY B O   1 
ATOM   5510 N N   . GLN C 1 281 ? 6.458   -18.132 14.687  1.00 13.31 ?  504  GLN B N   1 
ATOM   5511 C CA  . GLN C 1 281 ? 5.309   -19.044 14.796  1.00 10.82 ?  504  GLN B CA  1 
ATOM   5512 C C   . GLN C 1 281 ? 5.851   -20.403 15.208  1.00 10.49 ?  504  GLN B C   1 
ATOM   5513 O O   . GLN C 1 281 ? 6.564   -21.053 14.420  1.00 11.39 ?  504  GLN B O   1 
ATOM   5514 C CB  . GLN C 1 281 ? 4.549   -19.178 13.478  1.00 13.06 ?  504  GLN B CB  1 
ATOM   5515 C CG  . GLN C 1 281 ? 3.531   -18.133 13.207  1.00 21.00 ?  504  GLN B CG  1 
ATOM   5516 C CD  . GLN C 1 281 ? 2.605   -18.500 12.019  1.00 29.40 ?  504  GLN B CD  1 
ATOM   5517 O OE1 . GLN C 1 281 ? 1.503   -17.976 11.900  1.00 36.34 ?  504  GLN B OE1 1 
ATOM   5518 N NE2 . GLN C 1 281 ? 3.073   -19.379 11.143  1.00 31.27 ?  504  GLN B NE2 1 
ATOM   5519 N N   . HIS C 1 282 ? 5.545   -20.836 16.437  1.00 8.64  ?  505  HIS B N   1 
ATOM   5520 C CA  . HIS C 1 282 ? 6.062   -22.091 16.940  1.00 8.79  ?  505  HIS B CA  1 
ATOM   5521 C C   . HIS C 1 282 ? 5.123   -22.775 17.923  1.00 8.72  ?  505  HIS B C   1 
ATOM   5522 O O   . HIS C 1 282 ? 4.613   -22.134 18.848  1.00 10.02 ?  505  HIS B O   1 
ATOM   5523 C CB  . HIS C 1 282 ? 7.425   -21.894 17.684  1.00 9.29  ?  505  HIS B CB  1 
ATOM   5524 C CG  . HIS C 1 282 ? 8.587   -21.599 16.780  1.00 9.83  ?  505  HIS B CG  1 
ATOM   5525 N ND1 . HIS C 1 282 ? 9.113   -20.328 16.646  1.00 12.49 ?  505  HIS B ND1 1 
ATOM   5526 C CD2 . HIS C 1 282 ? 9.347   -22.407 16.003  1.00 9.71  ?  505  HIS B CD2 1 
ATOM   5527 C CE1 . HIS C 1 282 ? 10.151  -20.369 15.811  1.00 12.95 ?  505  HIS B CE1 1 
ATOM   5528 N NE2 . HIS C 1 282 ? 10.309  -21.617 15.404  1.00 10.78 ?  505  HIS B NE2 1 
ATOM   5529 N N   . ASP C 1 283 ? 5.048   -24.107 17.820  1.00 8.35  ?  506  ASP B N   1 
ATOM   5530 C CA  . ASP C 1 283 ? 4.682   -24.939 18.963  1.00 8.17  ?  506  ASP B CA  1 
ATOM   5531 C C   . ASP C 1 283 ? 5.827   -24.915 19.971  1.00 9.38  ?  506  ASP B C   1 
ATOM   5532 O O   . ASP C 1 283 ? 6.998   -24.976 19.581  1.00 10.88 ?  506  ASP B O   1 
ATOM   5533 C CB  . ASP C 1 283 ? 4.458   -26.397 18.547  1.00 8.51  ?  506  ASP B CB  1 
ATOM   5534 C CG  . ASP C 1 283 ? 3.268   -26.617 17.639  1.00 13.02 ?  506  ASP B CG  1 
ATOM   5535 O OD1 . ASP C 1 283 ? 2.305   -25.836 17.658  1.00 11.70 ?  506  ASP B OD1 1 
ATOM   5536 O OD2 . ASP C 1 283 ? 3.280   -27.676 16.951  1.00 13.44 -1 506  ASP B OD2 1 
ATOM   5537 N N   . LEU C 1 284 ? 5.496   -24.883 21.264  1.00 8.83  ?  507  LEU B N   1 
ATOM   5538 C CA  . LEU C 1 284 ? 6.541   -24.958 22.304  1.00 7.66  ?  507  LEU B CA  1 
ATOM   5539 C C   . LEU C 1 284 ? 6.858   -26.426 22.634  1.00 11.43 ?  507  LEU B C   1 
ATOM   5540 O O   . LEU C 1 284 ? 5.961   -27.253 22.851  1.00 11.01 ?  507  LEU B O   1 
ATOM   5541 C CB  . LEU C 1 284 ? 6.084   -24.222 23.568  1.00 9.03  ?  507  LEU B CB  1 
ATOM   5542 C CG  . LEU C 1 284 ? 5.765   -22.732 23.440  1.00 9.81  ?  507  LEU B CG  1 
ATOM   5543 C CD1 . LEU C 1 284 ? 5.704   -22.098 24.824  1.00 11.02 ?  507  LEU B CD1 1 
ATOM   5544 C CD2 . LEU C 1 284 ? 6.760   -21.969 22.582  1.00 13.02 ?  507  LEU B CD2 1 
ATOM   5545 N N   . VAL C 1 285 ? 8.153   -26.772 22.664  1.00 9.89  ?  508  VAL B N   1 
ATOM   5546 C CA  . VAL C 1 285 ? 8.591   -28.101 23.072  1.00 10.49 ?  508  VAL B CA  1 
ATOM   5547 C C   . VAL C 1 285 ? 8.740   -28.096 24.593  1.00 12.06 ?  508  VAL B C   1 
ATOM   5548 O O   . VAL C 1 285 ? 9.539   -27.319 25.139  1.00 12.90 ?  508  VAL B O   1 
ATOM   5549 C CB  . VAL C 1 285 ? 9.913   -28.460 22.384  1.00 11.29 ?  508  VAL B CB  1 
ATOM   5550 C CG1 . VAL C 1 285 ? 10.379  -29.843 22.866  1.00 13.85 ?  508  VAL B CG1 1 
ATOM   5551 C CG2 . VAL C 1 285 ? 9.697   -28.419 20.869  1.00 11.78 ?  508  VAL B CG2 1 
ATOM   5552 N N   . ILE C 1 286 ? 7.905   -28.885 25.279  1.00 11.75 ?  509  ILE B N   1 
ATOM   5553 C CA  . ILE C 1 286 ? 7.859   -28.870 26.748  1.00 12.51 ?  509  ILE B CA  1 
ATOM   5554 C C   . ILE C 1 286 ? 7.916   -30.296 27.288  1.00 14.38 ?  509  ILE B C   1 
ATOM   5555 O O   . ILE C 1 286 ? 7.485   -31.256 26.622  1.00 12.39 ?  509  ILE B O   1 
ATOM   5556 C CB  . ILE C 1 286 ? 6.591   -28.172 27.275  1.00 11.29 ?  509  ILE B CB  1 
ATOM   5557 C CG1 . ILE C 1 286 ? 5.328   -28.813 26.659  1.00 12.32 ?  509  ILE B CG1 1 
ATOM   5558 C CG2 . ILE C 1 286 ? 6.610   -26.672 27.024  1.00 11.90 ?  509  ILE B CG2 1 
ATOM   5559 C CD1 . ILE C 1 286 ? 4.008   -28.244 27.202  1.00 11.69 ?  509  ILE B CD1 1 
ATOM   5560 N N   . PRO C 1 287 ? 8.443   -30.479 28.489  1.00 12.94 ?  510  PRO B N   1 
ATOM   5561 C CA  . PRO C 1 287 ? 8.322   -31.779 29.155  1.00 12.13 ?  510  PRO B CA  1 
ATOM   5562 C C   . PRO C 1 287 ? 6.869   -32.047 29.496  1.00 14.48 ?  510  PRO B C   1 
ATOM   5563 O O   . PRO C 1 287 ? 6.129   -31.140 29.900  1.00 13.56 ?  510  PRO B O   1 
ATOM   5564 C CB  . PRO C 1 287 ? 9.190   -31.610 30.429  1.00 15.23 ?  510  PRO B CB  1 
ATOM   5565 C CG  . PRO C 1 287 ? 9.134   -30.154 30.700  1.00 15.28 ?  510  PRO B CG  1 
ATOM   5566 C CD  . PRO C 1 287 ? 9.137   -29.482 29.323  1.00 12.66 ?  510  PRO B CD  1 
ATOM   5567 N N   . PRO C 1 288 ? 6.402   -33.275 29.327  1.00 16.47 ?  511  PRO B N   1 
ATOM   5568 C CA  . PRO C 1 288 ? 4.942   -33.514 29.460  1.00 16.06 ?  511  PRO B CA  1 
ATOM   5569 C C   . PRO C 1 288 ? 4.444   -33.395 30.901  1.00 16.83 ?  511  PRO B C   1 
ATOM   5570 O O   . PRO C 1 288 ? 3.230   -33.200 31.095  1.00 15.95 ?  511  PRO B O   1 
ATOM   5571 C CB  . PRO C 1 288 ? 4.762   -34.939 28.907  1.00 20.50 ?  511  PRO B CB  1 
ATOM   5572 C CG  . PRO C 1 288 ? 6.152   -35.582 29.076  1.00 21.40 ?  511  PRO B CG  1 
ATOM   5573 C CD  . PRO C 1 288 ? 7.153   -34.440 28.829  1.00 17.98 ?  511  PRO B CD  1 
ATOM   5574 N N   . ASN C 1 289 ? 5.348   -33.396 31.884  1.00 15.15 ?  512  ASN B N   1 
ATOM   5575 C CA  . ASN C 1 289 ? 5.016   -33.115 33.290  1.00 14.75 ?  512  ASN B CA  1 
ATOM   5576 C C   . ASN C 1 289 ? 5.245   -31.665 33.695  1.00 13.00 ?  512  ASN B C   1 
ATOM   5577 O O   . ASN C 1 289 ? 5.048   -31.320 34.879  1.00 15.08 ?  512  ASN B O   1 
ATOM   5578 C CB  . ASN C 1 289 ? 5.818   -34.041 34.222  1.00 18.75 ?  512  ASN B CB  1 
ATOM   5579 C CG  . ASN C 1 289 ? 7.335   -33.885 34.073  1.00 24.27 ?  512  ASN B CG  1 
ATOM   5580 O OD1 . ASN C 1 289 ? 7.880   -33.406 33.052  1.00 23.28 ?  512  ASN B OD1 1 
ATOM   5581 N ND2 . ASN C 1 289 ? 8.039   -34.296 35.117  1.00 28.18 ?  512  ASN B ND2 1 
ATOM   5582 N N   . GLY C 1 290 ? 5.590   -30.790 32.746  1.00 10.34 ?  513  GLY B N   1 
ATOM   5583 C CA  . GLY C 1 290 ? 5.729   -29.369 33.073  1.00 11.05 ?  513  GLY B CA  1 
ATOM   5584 C C   . GLY C 1 290 ? 4.417   -28.734 33.499  1.00 11.03 ?  513  GLY B C   1 
ATOM   5585 O O   . GLY C 1 290 ? 3.323   -29.153 33.134  1.00 12.23 ?  513  GLY B O   1 
ATOM   5586 N N   . TYR C 1 291 ? 4.532   -27.642 34.262  1.00 10.55 ?  514  TYR B N   1 
ATOM   5587 C CA  . TYR C 1 291 ? 3.319   -26.944 34.670  1.00 12.13 ?  514  TYR B CA  1 
ATOM   5588 C C   . TYR C 1 291 ? 3.665   -25.490 34.960  1.00 11.60 ?  514  TYR B C   1 
ATOM   5589 O O   . TYR C 1 291 ? 4.837   -25.115 35.096  1.00 11.43 ?  514  TYR B O   1 
ATOM   5590 C CB  . TYR C 1 291 ? 2.650   -27.603 35.883  1.00 17.46 ?  514  TYR B CB  1 
ATOM   5591 C CG  . TYR C 1 291 ? 3.505   -27.436 37.110  1.00 16.95 ?  514  TYR B CG  1 
ATOM   5592 C CD1 . TYR C 1 291 ? 4.749   -28.076 37.223  1.00 23.06 ?  514  TYR B CD1 1 
ATOM   5593 C CD2 . TYR C 1 291 ? 3.177   -26.487 38.066  1.00 20.23 ?  514  TYR B CD2 1 
ATOM   5594 C CE1 . TYR C 1 291 ? 5.582   -27.852 38.322  1.00 25.87 ?  514  TYR B CE1 1 
ATOM   5595 C CE2 . TYR C 1 291 ? 3.977   -26.282 39.174  1.00 22.21 ?  514  TYR B CE2 1 
ATOM   5596 C CZ  . TYR C 1 291 ? 5.170   -26.948 39.302  1.00 31.98 ?  514  TYR B CZ  1 
ATOM   5597 O OH  . TYR C 1 291 ? 5.948   -26.666 40.410  1.00 36.51 ?  514  TYR B OH  1 
ATOM   5598 N N   . PHE C 1 292 ? 2.616   -24.673 35.028  1.00 11.76 ?  515  PHE B N   1 
ATOM   5599 C CA  . PHE C 1 292 ? 2.758   -23.243 35.312  1.00 10.08 ?  515  PHE B CA  1 
ATOM   5600 C C   . PHE C 1 292 ? 2.730   -22.956 36.811  1.00 11.98 ?  515  PHE B C   1 
ATOM   5601 O O   . PHE C 1 292 ? 1.914   -23.515 37.543  1.00 11.39 ?  515  PHE B O   1 
ATOM   5602 C CB  . PHE C 1 292 ? 1.627   -22.442 34.674  1.00 9.03  ?  515  PHE B CB  1 
ATOM   5603 C CG  . PHE C 1 292 ? 1.640   -22.437 33.150  1.00 11.37 ?  515  PHE B CG  1 
ATOM   5604 C CD1 . PHE C 1 292 ? 1.045   -23.464 32.426  1.00 10.42 ?  515  PHE B CD1 1 
ATOM   5605 C CD2 . PHE C 1 292 ? 2.239   -21.392 32.454  1.00 9.07  ?  515  PHE B CD2 1 
ATOM   5606 C CE1 . PHE C 1 292 ? 1.055   -23.454 31.010  1.00 9.39  ?  515  PHE B CE1 1 
ATOM   5607 C CE2 . PHE C 1 292 ? 2.241   -21.344 31.064  1.00 9.58  ?  515  PHE B CE2 1 
ATOM   5608 C CZ  . PHE C 1 292 ? 1.625   -22.388 30.319  1.00 9.76  ?  515  PHE B CZ  1 
ATOM   5609 N N   . ARG C 1 293 ? 3.526   -21.965 37.223  1.00 10.25 ?  516  ARG B N   1 
ATOM   5610 C CA  . ARG C 1 293 ? 3.645   -21.585 38.639  1.00 12.69 ?  516  ARG B CA  1 
ATOM   5611 C C   . ARG C 1 293 ? 3.650   -20.067 38.756  1.00 11.03 ?  516  ARG B C   1 
ATOM   5612 O O   . ARG C 1 293 ? 4.490   -19.390 38.157  1.00 12.40 ?  516  ARG B O   1 
ATOM   5613 C CB  . ARG C 1 293 ? 4.949   -22.175 39.220  1.00 13.76 ?  516  ARG B CB  1 
ATOM   5614 C CG  . ARG C 1 293 ? 5.190   -21.917 40.731  1.00 15.93 ?  516  ARG B CG  1 
ATOM   5615 C CD  . ARG C 1 293 ? 6.654   -22.327 41.102  1.00 16.36 ?  516  ARG B CD  1 
ATOM   5616 N NE  . ARG C 1 293 ? 7.645   -21.372 40.594  1.00 19.12 ?  516  ARG B NE  1 
ATOM   5617 C CZ  . ARG C 1 293 ? 8.926   -21.637 40.372  1.00 17.29 ?  516  ARG B CZ  1 
ATOM   5618 N NH1 . ARG C 1 293 ? 9.452   -22.825 40.658  1.00 21.35 ?  516  ARG B NH1 1 
ATOM   5619 N NH2 . ARG C 1 293 ? 9.706   -20.699 39.839  1.00 18.99 ?  516  ARG B NH2 1 
ATOM   5620 N N   . PHE C 1 294 ? 2.729   -19.530 39.551  1.00 11.37 ?  517  PHE B N   1 
ATOM   5621 C CA  . PHE C 1 294 ? 2.721   -18.079 39.793  1.00 10.58 ?  517  PHE B CA  1 
ATOM   5622 C C   . PHE C 1 294 ? 3.857   -17.682 40.743  1.00 13.00 ?  517  PHE B C   1 
ATOM   5623 O O   . PHE C 1 294 ? 3.947   -18.201 41.869  1.00 13.75 ?  517  PHE B O   1 
ATOM   5624 C CB  . PHE C 1 294 ? 1.389   -17.697 40.408  1.00 11.82 ?  517  PHE B CB  1 
ATOM   5625 C CG  . PHE C 1 294 ? 1.361   -16.277 40.957  1.00 13.23 ?  517  PHE B CG  1 
ATOM   5626 C CD1 . PHE C 1 294 ? 1.449   -15.202 40.113  1.00 13.97 ?  517  PHE B CD1 1 
ATOM   5627 C CD2 . PHE C 1 294 ? 1.244   -16.064 42.310  1.00 14.63 ?  517  PHE B CD2 1 
ATOM   5628 C CE1 . PHE C 1 294 ? 1.413   -13.866 40.600  1.00 10.52 ?  517  PHE B CE1 1 
ATOM   5629 C CE2 . PHE C 1 294 ? 1.253   -14.760 42.819  1.00 13.76 ?  517  PHE B CE2 1 
ATOM   5630 C CZ  . PHE C 1 294 ? 1.287   -13.671 41.971  1.00 14.21 ?  517  PHE B CZ  1 
ATOM   5631 N N   . ASP C 1 295 ? 4.660   -16.725 40.329  1.00 11.55 ?  518  ASP B N   1 
ATOM   5632 C CA  . ASP C 1 295 ? 5.789   -16.280 41.153  1.00 13.87 ?  518  ASP B CA  1 
ATOM   5633 C C   . ASP C 1 295 ? 5.624   -14.879 41.730  1.00 17.36 ?  518  ASP B C   1 
ATOM   5634 O O   . ASP C 1 295 ? 6.003   -14.685 42.904  1.00 18.15 ?  518  ASP B O   1 
ATOM   5635 C CB  . ASP C 1 295 ? 7.067   -16.392 40.343  1.00 14.60 ?  518  ASP B CB  1 
ATOM   5636 C CG  . ASP C 1 295 ? 7.549   -17.833 40.252  1.00 15.67 ?  518  ASP B CG  1 
ATOM   5637 O OD1 . ASP C 1 295 ? 6.983   -18.711 40.943  1.00 17.75 ?  518  ASP B OD1 1 
ATOM   5638 O OD2 . ASP C 1 295 ? 8.518   -18.096 39.510  1.00 18.22 -1 518  ASP B OD2 1 
ATOM   5639 N N   . SER C 1 296 ? 5.043   -13.911 41.006  1.00 13.79 ?  519  SER B N   1 
ATOM   5640 C CA  . SER C 1 296 ? 5.041   -12.513 41.457  1.00 13.59 ?  519  SER B CA  1 
ATOM   5641 C C   . SER C 1 296 ? 4.056   -11.665 40.668  1.00 14.82 ?  519  SER B C   1 
ATOM   5642 O O   . SER C 1 296 ? 3.907   -11.852 39.451  1.00 12.97 ?  519  SER B O   1 
ATOM   5643 C CB  . SER C 1 296 ? 6.449   -11.902 41.270  1.00 14.59 ?  519  SER B CB  1 
ATOM   5644 O OG  . SER C 1 296 ? 6.448   -10.644 41.870  1.00 27.99 ?  519  SER B OG  1 
ATOM   5645 N N   . TRP C 1 297 ? 3.416   -10.709 41.342  1.00 12.01 ?  520  TRP B N   1 
ATOM   5646 C CA  . TRP C 1 297 ? 2.779   -9.602  40.635  1.00 11.68 ?  520  TRP B CA  1 
ATOM   5647 C C   . TRP C 1 297 ? 3.862   -8.630  40.174  1.00 14.90 ?  520  TRP B C   1 
ATOM   5648 O O   . TRP C 1 297 ? 4.817   -8.348  40.920  1.00 18.39 ?  520  TRP B O   1 
ATOM   5649 C CB  . TRP C 1 297 ? 1.739   -8.901  41.511  1.00 15.18 ?  520  TRP B CB  1 
ATOM   5650 C CG  . TRP C 1 297 ? 0.565   -9.771  41.866  1.00 13.69 ?  520  TRP B CG  1 
ATOM   5651 C CD1 . TRP C 1 297 ? 0.355   -10.430 43.053  1.00 15.63 ?  520  TRP B CD1 1 
ATOM   5652 C CD2 . TRP C 1 297 ? -0.528  -10.093 41.021  1.00 12.87 ?  520  TRP B CD2 1 
ATOM   5653 N NE1 . TRP C 1 297 ? -0.825  -11.147 42.991  1.00 16.45 ?  520  TRP B NE1 1 
ATOM   5654 C CE2 . TRP C 1 297 ? -1.393  -10.954 41.755  1.00 16.01 ?  520  TRP B CE2 1 
ATOM   5655 C CE3 . TRP C 1 297 ? -0.883  -9.732  39.715  1.00 13.04 ?  520  TRP B CE3 1 
ATOM   5656 C CZ2 . TRP C 1 297 ? -2.584  -11.478 41.194  1.00 14.20 ?  520  TRP B CZ2 1 
ATOM   5657 C CZ3 . TRP C 1 297 ? -2.072  -10.232 39.179  1.00 15.10 ?  520  TRP B CZ3 1 
ATOM   5658 C CH2 . TRP C 1 297 ? -2.894  -11.110 39.918  1.00 12.99 ?  520  TRP B CH2 1 
ATOM   5659 N N   . VAL C 1 298 ? 3.758   -8.148  38.928  1.00 12.23 ?  521  VAL B N   1 
ATOM   5660 C CA  . VAL C 1 298 ? 4.766   -7.226  38.406  1.00 13.47 ?  521  VAL B CA  1 
ATOM   5661 C C   . VAL C 1 298 ? 4.092   -5.986  37.827  1.00 12.98 ?  521  VAL B C   1 
ATOM   5662 O O   . VAL C 1 298 ? 2.885   -5.956  37.578  1.00 14.21 ?  521  VAL B O   1 
ATOM   5663 C CB  . VAL C 1 298 ? 5.704   -7.877  37.349  1.00 13.66 ?  521  VAL B CB  1 
ATOM   5664 C CG1 . VAL C 1 298 ? 6.535   -8.985  38.001  1.00 15.17 ?  521  VAL B CG1 1 
ATOM   5665 C CG2 . VAL C 1 298 ? 4.887   -8.427  36.137  1.00 10.21 ?  521  VAL B CG2 1 
ATOM   5666 N N   . ASN C 1 299 ? 4.895   -4.925  37.646  1.00 13.07 ?  522  ASN B N   1 
ATOM   5667 C CA  . ASN C 1 299 ? 4.353   -3.704  37.085  1.00 12.66 ?  522  ASN B CA  1 
ATOM   5668 C C   . ASN C 1 299 ? 4.059   -3.891  35.590  1.00 14.74 ?  522  ASN B C   1 
ATOM   5669 O O   . ASN C 1 299 ? 4.544   -4.840  34.943  1.00 13.49 ?  522  ASN B O   1 
ATOM   5670 C CB  . ASN C 1 299 ? 5.315   -2.497  37.358  1.00 15.14 ?  522  ASN B CB  1 
ATOM   5671 C CG  . ASN C 1 299 ? 6.590   -2.522  36.527  1.00 13.60 ?  522  ASN B CG  1 
ATOM   5672 O OD1 . ASN C 1 299 ? 6.546   -2.378  35.302  1.00 15.76 ?  522  ASN B OD1 1 
ATOM   5673 N ND2 . ASN C 1 299 ? 7.752   -2.682  37.186  1.00 17.26 ?  522  ASN B ND2 1 
ATOM   5674 N N   . GLN C 1 300 ? 3.275   -2.954  35.036  1.00 14.67 ?  523  GLN B N   1 
ATOM   5675 C CA  . GLN C 1 300 ? 2.781   -3.126  33.672  1.00 16.39 ?  523  GLN B CA  1 
ATOM   5676 C C   . GLN C 1 300 ? 3.867   -2.984  32.601  1.00 18.52 ?  523  GLN B C   1 
ATOM   5677 O O   . GLN C 1 300 ? 3.605   -3.356  31.447  1.00 20.39 ?  523  GLN B O   1 
ATOM   5678 C CB  . GLN C 1 300 ? 1.611   -2.164  33.469  1.00 22.03 ?  523  GLN B CB  1 
ATOM   5679 C CG  . GLN C 1 300 ? 2.043   -0.786  33.192  1.00 22.26 ?  523  GLN B CG  1 
ATOM   5680 C CD  . GLN C 1 300 ? 1.006   0.039   32.438  1.00 31.47 ?  523  GLN B CD  1 
ATOM   5681 O OE1 . GLN C 1 300 ? 0.461   0.997   33.004  1.00 38.06 ?  523  GLN B OE1 1 
ATOM   5682 N NE2 . GLN C 1 300 ? 0.708   -0.332  31.183  1.00 35.07 ?  523  GLN B NE2 1 
ATOM   5683 N N   . PHE C 1 301 ? 5.090   -2.522  32.947  1.00 13.01 ?  524  PHE B N   1 
ATOM   5684 C CA  . PHE C 1 301 ? 6.168   -2.369  31.972  1.00 12.73 ?  524  PHE B CA  1 
ATOM   5685 C C   . PHE C 1 301 ? 7.201   -3.492  32.030  1.00 11.78 ?  524  PHE B C   1 
ATOM   5686 O O   . PHE C 1 301 ? 8.220   -3.409  31.335  1.00 12.88 ?  524  PHE B O   1 
ATOM   5687 C CB  . PHE C 1 301 ? 6.862   -0.977  32.163  1.00 11.17 ?  524  PHE B CB  1 
ATOM   5688 C CG  . PHE C 1 301 ? 5.912   0.165   31.990  1.00 11.98 ?  524  PHE B CG  1 
ATOM   5689 C CD1 . PHE C 1 301 ? 5.502   0.559   30.714  1.00 13.17 ?  524  PHE B CD1 1 
ATOM   5690 C CD2 . PHE C 1 301 ? 5.350   0.794   33.113  1.00 15.30 ?  524  PHE B CD2 1 
ATOM   5691 C CE1 . PHE C 1 301 ? 4.582   1.598   30.537  1.00 14.24 ?  524  PHE B CE1 1 
ATOM   5692 C CE2 . PHE C 1 301 ? 4.431   1.826   32.956  1.00 16.16 ?  524  PHE B CE2 1 
ATOM   5693 C CZ  . PHE C 1 301 ? 4.045   2.235   31.686  1.00 15.31 ?  524  PHE B CZ  1 
ATOM   5694 N N   . TYR C 1 302 ? 6.937   -4.567  32.799  1.00 11.59 ?  525  TYR B N   1 
ATOM   5695 C CA  . TYR C 1 302 ? 7.887   -5.644  33.038  1.00 10.98 ?  525  TYR B CA  1 
ATOM   5696 C C   . TYR C 1 302 ? 8.382   -6.221  31.716  1.00 12.52 ?  525  TYR B C   1 
ATOM   5697 O O   . TYR C 1 302 ? 7.595   -6.419  30.782  1.00 12.31 ?  525  TYR B O   1 
ATOM   5698 C CB  . TYR C 1 302 ? 7.217   -6.756  33.891  1.00 11.94 ?  525  TYR B CB  1 
ATOM   5699 C CG  . TYR C 1 302 ? 8.154   -7.898  34.137  1.00 12.71 ?  525  TYR B CG  1 
ATOM   5700 C CD1 . TYR C 1 302 ? 9.134   -7.827  35.119  1.00 18.04 ?  525  TYR B CD1 1 
ATOM   5701 C CD2 . TYR C 1 302 ? 8.069   -9.052  33.341  1.00 13.45 ?  525  TYR B CD2 1 
ATOM   5702 C CE1 . TYR C 1 302 ? 10.022  -8.893  35.304  1.00 17.97 ?  525  TYR B CE1 1 
ATOM   5703 C CE2 . TYR C 1 302 ? 8.899   -10.084 33.510  1.00 17.15 ?  525  TYR B CE2 1 
ATOM   5704 C CZ  . TYR C 1 302 ? 9.881   -10.029 34.483  1.00 14.42 ?  525  TYR B CZ  1 
ATOM   5705 O OH  . TYR C 1 302 ? 10.726  -11.129 34.596  1.00 20.18 ?  525  TYR B OH  1 
ATOM   5706 N N   . THR C 1 303 ? 9.700   -6.483  31.626  1.00 12.00 ?  526  THR B N   1 
ATOM   5707 C CA  . THR C 1 303 ? 10.293  -7.085  30.421  1.00 11.20 ?  526  THR B CA  1 
ATOM   5708 C C   . THR C 1 303 ? 10.413  -8.593  30.636  1.00 12.65 ?  526  THR B C   1 
ATOM   5709 O O   . THR C 1 303 ? 11.201  -9.073  31.473  1.00 12.04 ?  526  THR B O   1 
ATOM   5710 C CB  . THR C 1 303 ? 11.671  -6.495  30.110  1.00 12.66 ?  526  THR B CB  1 
ATOM   5711 O OG1 . THR C 1 303 ? 11.552  -5.063  29.932  1.00 13.23 ?  526  THR B OG1 1 
ATOM   5712 C CG2 . THR C 1 303 ? 12.226  -7.084  28.822  1.00 13.01 ?  526  THR B CG2 1 
ATOM   5713 N N   . LEU C 1 304 ? 9.654   -9.361  29.857  1.00 10.97 ?  527  LEU B N   1 
ATOM   5714 C CA  . LEU C 1 304 ? 9.835   -10.801 29.912  1.00 12.34 ?  527  LEU B CA  1 
ATOM   5715 C C   . LEU C 1 304 ? 11.196  -11.247 29.377  1.00 10.97 ?  527  LEU B C   1 
ATOM   5716 O O   . LEU C 1 304 ? 11.697  -10.729 28.372  1.00 13.52 ?  527  LEU B O   1 
ATOM   5717 C CB  . LEU C 1 304 ? 8.714   -11.461 29.074  1.00 11.61 ?  527  LEU B CB  1 
ATOM   5718 C CG  . LEU C 1 304 ? 7.318   -11.497 29.681  1.00 8.50  ?  527  LEU B CG  1 
ATOM   5719 C CD1 . LEU C 1 304 ? 6.296   -11.740 28.566  1.00 10.97 ?  527  LEU B CD1 1 
ATOM   5720 C CD2 . LEU C 1 304 ? 7.283   -12.633 30.700  1.00 12.36 ?  527  LEU B CD2 1 
ATOM   5721 N N   . ALA C 1 305 ? 11.727  -12.312 29.989  1.00 12.27 ?  528  ALA B N   1 
ATOM   5722 C CA  . ALA C 1 305 ? 12.920  -12.973 29.464  1.00 13.78 ?  528  ALA B CA  1 
ATOM   5723 C C   . ALA C 1 305 ? 12.572  -13.632 28.136  1.00 15.47 ?  528  ALA B C   1 
ATOM   5724 O O   . ALA C 1 305 ? 11.561  -14.342 28.046  1.00 13.35 ?  528  ALA B O   1 
ATOM   5725 C CB  . ALA C 1 305 ? 13.432  -14.003 30.453  1.00 14.91 ?  528  ALA B CB  1 
ATOM   5726 N N   . PRO C 1 306 ? 13.327  -13.392 27.082  1.00 14.59 ?  529  PRO B N   1 
ATOM   5727 C CA  . PRO C 1 306 ? 12.971  -13.988 25.785  1.00 15.83 ?  529  PRO B CA  1 
ATOM   5728 C C   . PRO C 1 306 ? 13.050  -15.507 25.817  1.00 19.52 ?  529  PRO B C   1 
ATOM   5729 O O   . PRO C 1 306 ? 13.838  -16.114 26.555  1.00 19.61 ?  529  PRO B O   1 
ATOM   5730 C CB  . PRO C 1 306 ? 13.979  -13.385 24.809  1.00 21.58 ?  529  PRO B CB  1 
ATOM   5731 C CG  . PRO C 1 306 ? 15.090  -12.904 25.654  1.00 25.27 ?  529  PRO B CG  1 
ATOM   5732 C CD  . PRO C 1 306 ? 14.490  -12.482 26.974  1.00 17.90 ?  529  PRO B CD  1 
ATOM   5733 N N   . MET C 1 307 ? 12.181  -16.123 25.023  1.00 18.37 ?  530  MET B N   1 
ATOM   5734 C CA  . MET C 1 307 ? 12.105  -17.586 25.021  1.00 15.90 ?  530  MET B CA  1 
ATOM   5735 C C   . MET C 1 307 ? 13.257  -18.033 24.115  1.00 20.05 ?  530  MET B C   1 
ATOM   5736 O O   . MET C 1 307 ? 13.862  -19.072 24.425  1.00 29.28 ?  530  MET B O   1 
ATOM   5737 C CB  . MET C 1 307 ? 10.757  -18.063 24.507  1.00 18.08 ?  530  MET B CB  1 
ATOM   5738 C CG  . MET C 1 307 ? 9.676   -17.926 25.542  1.00 23.51 ?  530  MET B CG  1 
ATOM   5739 S SD  . MET C 1 307 ? 8.318   -19.044 25.179  1.00 29.52 ?  530  MET B SD  1 
ATOM   5740 C CE  . MET C 1 307 ? 7.767   -18.314 23.655  1.00 21.41 ?  530  MET B CE  1 
ATOM   5741 N N   . GLN D 2 1   ? -36.146 -17.107 5.295   1.00 24.22 ?  1    GLN D N   1 
ATOM   5742 C CA  . GLN D 2 1   ? -34.974 -17.974 5.363   1.00 27.15 ?  1    GLN D CA  1 
ATOM   5743 C C   . GLN D 2 1   ? -34.265 -17.960 3.995   1.00 23.22 ?  1    GLN D C   1 
ATOM   5744 O O   . GLN D 2 1   ? -34.913 -17.685 2.965   1.00 20.09 ?  1    GLN D O   1 
ATOM   5745 C CB  . GLN D 2 1   ? -35.365 -19.408 5.727   1.00 31.94 ?  1    GLN D CB  1 
ATOM   5746 C CG  . GLN D 2 1   ? -36.165 -20.120 4.653   1.00 38.16 ?  1    GLN D CG  1 
ATOM   5747 C CD  . GLN D 2 1   ? -37.616 -19.650 4.567   1.00 50.57 ?  1    GLN D CD  1 
ATOM   5748 O OE1 . GLN D 2 1   ? -37.887 -18.470 4.272   1.00 47.10 ?  1    GLN D OE1 1 
ATOM   5749 N NE2 . GLN D 2 1   ? -38.561 -20.581 4.779   1.00 54.28 ?  1    GLN D NE2 1 
ATOM   5750 N N   . VAL D 2 2   ? -32.955 -18.232 3.980   1.00 19.87 ?  2    VAL D N   1 
ATOM   5751 C CA  . VAL D 2 2   ? -32.235 -18.326 2.717   1.00 19.09 ?  2    VAL D CA  1 
ATOM   5752 C C   . VAL D 2 2   ? -32.689 -19.583 2.000   1.00 17.96 ?  2    VAL D C   1 
ATOM   5753 O O   . VAL D 2 2   ? -32.940 -20.603 2.643   1.00 20.03 ?  2    VAL D O   1 
ATOM   5754 C CB  . VAL D 2 2   ? -30.714 -18.356 2.944   1.00 21.35 ?  2    VAL D CB  1 
ATOM   5755 C CG1 . VAL D 2 2   ? -30.010 -18.664 1.623   1.00 18.21 ?  2    VAL D CG1 1 
ATOM   5756 C CG2 . VAL D 2 2   ? -30.240 -17.023 3.486   1.00 20.13 ?  2    VAL D CG2 1 
ATOM   5757 N N   . GLN D 2 3   ? -32.852 -19.503 0.673   1.00 15.07 ?  3    GLN D N   1 
ATOM   5758 C CA  . GLN D 2 3   ? -33.136 -20.675 -0.149  1.00 16.53 ?  3    GLN D CA  1 
ATOM   5759 C C   . GLN D 2 3   ? -32.292 -20.607 -1.412  1.00 16.02 ?  3    GLN D C   1 
ATOM   5760 O O   . GLN D 2 3   ? -32.104 -19.530 -1.990  1.00 14.52 ?  3    GLN D O   1 
ATOM   5761 C CB  . GLN D 2 3   ? -34.626 -20.755 -0.532  1.00 17.58 ?  3    GLN D CB  1 
ATOM   5762 C CG  . GLN D 2 3   ? -35.470 -20.741 0.713   1.00 21.32 ?  3    GLN D CG  1 
ATOM   5763 C CD  . GLN D 2 3   ? -36.747 -21.506 0.553   1.00 29.76 ?  3    GLN D CD  1 
ATOM   5764 O OE1 . GLN D 2 3   ? -36.838 -22.680 0.898   1.00 39.10 ?  3    GLN D OE1 1 
ATOM   5765 N NE2 . GLN D 2 3   ? -37.762 -20.830 0.043   1.00 39.16 ?  3    GLN D NE2 1 
ATOM   5766 N N   . LEU D 2 4   ? -31.790 -21.775 -1.825  1.00 12.33 ?  4    LEU D N   1 
ATOM   5767 C CA  . LEU D 2 4   ? -30.913 -21.914 -2.974  1.00 12.81 ?  4    LEU D CA  1 
ATOM   5768 C C   . LEU D 2 4   ? -31.479 -23.009 -3.868  1.00 14.22 ?  4    LEU D C   1 
ATOM   5769 O O   . LEU D 2 4   ? -31.766 -24.097 -3.371  1.00 15.04 ?  4    LEU D O   1 
ATOM   5770 C CB  . LEU D 2 4   ? -29.486 -22.321 -2.527  1.00 12.35 ?  4    LEU D CB  1 
ATOM   5771 C CG  . LEU D 2 4   ? -28.833 -21.381 -1.510  1.00 12.15 ?  4    LEU D CG  1 
ATOM   5772 C CD1 . LEU D 2 4   ? -27.600 -22.066 -0.851  1.00 9.90  ?  4    LEU D CD1 1 
ATOM   5773 C CD2 . LEU D 2 4   ? -28.364 -20.187 -2.307  1.00 11.45 ?  4    LEU D CD2 1 
ATOM   5774 N N   . GLN D 2 5   ? -31.657 -22.735 -5.165  1.00 12.01 ?  5    GLN D N   1 
ATOM   5775 C CA  . GLN D 2 5   ? -32.279 -23.712 -6.059  1.00 13.43 ?  5    GLN D CA  1 
ATOM   5776 C C   . GLN D 2 5   ? -31.544 -23.748 -7.397  1.00 12.69 ?  5    GLN D C   1 
ATOM   5777 O O   . GLN D 2 5   ? -31.681 -22.818 -8.203  1.00 13.42 ?  5    GLN D O   1 
ATOM   5778 C CB  . GLN D 2 5   ? -33.770 -23.354 -6.255  1.00 16.18 ?  5    GLN D CB  1 
ATOM   5779 C CG  . GLN D 2 5   ? -34.636 -24.291 -7.136  1.00 21.15 ?  5    GLN D CG  1 
ATOM   5780 C CD  . GLN D 2 5   ? -34.912 -25.641 -6.558  1.00 23.83 ?  5    GLN D CD  1 
ATOM   5781 O OE1 . GLN D 2 5   ? -35.026 -25.805 -5.340  1.00 35.22 ?  5    GLN D OE1 1 
ATOM   5782 N NE2 . GLN D 2 5   ? -35.186 -26.601 -7.446  1.00 25.18 ?  5    GLN D NE2 1 
ATOM   5783 N N   . GLU D 2 6   ? -30.806 -24.836 -7.654  1.00 10.78 ?  6    GLU D N   1 
ATOM   5784 C CA  . GLU D 2 6   ? -30.075 -25.038 -8.898  1.00 10.39 ?  6    GLU D CA  1 
ATOM   5785 C C   . GLU D 2 6   ? -30.928 -25.726 -9.952  1.00 9.95  ?  6    GLU D C   1 
ATOM   5786 O O   . GLU D 2 6   ? -31.796 -26.541 -9.638  1.00 12.26 ?  6    GLU D O   1 
ATOM   5787 C CB  . GLU D 2 6   ? -28.867 -25.936 -8.649  1.00 9.50  ?  6    GLU D CB  1 
ATOM   5788 C CG  . GLU D 2 6   ? -27.889 -25.380 -7.618  1.00 9.61  ?  6    GLU D CG  1 
ATOM   5789 C CD  . GLU D 2 6   ? -28.189 -25.786 -6.169  1.00 10.88 ?  6    GLU D CD  1 
ATOM   5790 O OE1 . GLU D 2 6   ? -29.300 -26.295 -5.819  1.00 10.38 ?  6    GLU D OE1 1 
ATOM   5791 O OE2 . GLU D 2 6   ? -27.293 -25.551 -5.314  1.00 9.72  -1 6    GLU D OE2 1 
ATOM   5792 N N   . SER D 2 7   ? -30.620 -25.435 -11.210 1.00 9.45  ?  7    SER D N   1 
ATOM   5793 C CA  . SER D 2 7   ? -31.289 -26.133 -12.329 1.00 10.48 ?  7    SER D CA  1 
ATOM   5794 C C   . SER D 2 7   ? -30.358 -26.113 -13.528 1.00 13.30 ?  7    SER D C   1 
ATOM   5795 O O   . SER D 2 7   ? -29.349 -25.401 -13.535 1.00 11.46 ?  7    SER D O   1 
ATOM   5796 C CB  . SER D 2 7   ? -32.626 -25.444 -12.686 1.00 13.09 ?  7    SER D CB  1 
ATOM   5797 O OG  . SER D 2 7   ? -32.389 -24.080 -13.039 1.00 15.02 ?  7    SER D OG  1 
ATOM   5798 N N   . GLY D 2 8   ? -30.698 -26.936 -14.547 1.00 11.64 ?  8    GLY D N   1 
ATOM   5799 C CA  . GLY D 2 8   ? -29.976 -26.928 -15.809 1.00 13.17 ?  8    GLY D CA  1 
ATOM   5800 C C   . GLY D 2 8   ? -29.132 -28.158 -16.089 1.00 15.65 ?  8    GLY D C   1 
ATOM   5801 O O   . GLY D 2 8   ? -28.635 -28.287 -17.216 1.00 18.46 ?  8    GLY D O   1 
ATOM   5802 N N   . GLY D 2 9   ? -28.990 -29.077 -15.155 1.00 13.20 ?  9    GLY D N   1 
ATOM   5803 C CA  . GLY D 2 9   ? -28.116 -30.219 -15.421 1.00 14.58 ?  9    GLY D CA  1 
ATOM   5804 C C   . GLY D 2 9   ? -28.687 -31.194 -16.447 1.00 16.49 ?  9    GLY D C   1 
ATOM   5805 O O   . GLY D 2 9   ? -29.802 -31.046 -16.973 1.00 20.03 ?  9    GLY D O   1 
ATOM   5806 N N   . GLY D 2 10  ? -27.890 -32.209 -16.741 1.00 9.52  ?  10   GLY D N   1 
ATOM   5807 C CA  . GLY D 2 10  ? -28.351 -33.326 -17.547 1.00 8.50  ?  10   GLY D CA  1 
ATOM   5808 C C   . GLY D 2 10  ? -27.157 -34.101 -18.067 1.00 11.71 ?  10   GLY D C   1 
ATOM   5809 O O   . GLY D 2 10  ? -26.058 -33.967 -17.555 1.00 10.14 ?  10   GLY D O   1 
ATOM   5810 N N   . LEU D 2 11  ? -27.415 -34.901 -19.096 1.00 10.55 ?  11   LEU D N   1 
ATOM   5811 C CA  . LEU D 2 11  ? -26.439 -35.760 -19.733 1.00 10.17 ?  11   LEU D CA  1 
ATOM   5812 C C   . LEU D 2 11  ? -25.958 -35.048 -20.992 1.00 10.91 ?  11   LEU D C   1 
ATOM   5813 O O   . LEU D 2 11  ? -26.768 -34.725 -21.877 1.00 10.70 ?  11   LEU D O   1 
ATOM   5814 C CB  . LEU D 2 11  ? -27.095 -37.114 -20.061 1.00 10.02 ?  11   LEU D CB  1 
ATOM   5815 C CG  . LEU D 2 11  ? -26.175 -38.099 -20.822 1.00 11.12 ?  11   LEU D CG  1 
ATOM   5816 C CD1 . LEU D 2 11  ? -25.034 -38.529 -19.908 1.00 11.76 ?  11   LEU D CD1 1 
ATOM   5817 C CD2 . LEU D 2 11  ? -26.934 -39.333 -21.295 1.00 12.16 ?  11   LEU D CD2 1 
ATOM   5818 N N   . VAL D 2 12  ? -24.639 -34.804 -21.084 1.00 11.11 ?  12   VAL D N   1 
ATOM   5819 C CA  . VAL D 2 12  ? -24.077 -34.018 -22.180 1.00 10.96 ?  12   VAL D CA  1 
ATOM   5820 C C   . VAL D 2 12  ? -22.865 -34.756 -22.746 1.00 14.96 ?  12   VAL D C   1 
ATOM   5821 O O   . VAL D 2 12  ? -22.171 -35.497 -22.037 1.00 12.49 ?  12   VAL D O   1 
ATOM   5822 C CB  . VAL D 2 12  ? -23.705 -32.594 -21.700 1.00 13.78 ?  12   VAL D CB  1 
ATOM   5823 C CG1 . VAL D 2 12  ? -22.604 -32.700 -20.665 1.00 12.99 ?  12   VAL D CG1 1 
ATOM   5824 C CG2 . VAL D 2 12  ? -23.312 -31.674 -22.869 1.00 15.17 ?  12   VAL D CG2 1 
ATOM   5825 N N   . GLN D 2 13  ? -22.667 -34.582 -24.052 1.00 16.31 ?  13   GLN D N   1 
ATOM   5826 C CA  . GLN D 2 13  ? -21.574 -35.191 -24.776 1.00 17.65 ?  13   GLN D CA  1 
ATOM   5827 C C   . GLN D 2 13  ? -20.257 -34.527 -24.386 1.00 13.40 ?  13   GLN D C   1 
ATOM   5828 O O   . GLN D 2 13  ? -20.205 -33.317 -24.195 1.00 15.73 ?  13   GLN D O   1 
ATOM   5829 C CB  . GLN D 2 13  ? -21.866 -35.035 -26.279 1.00 20.78 ?  13   GLN D CB  1 
ATOM   5830 C CG  . GLN D 2 13  ? -20.938 -35.777 -27.198 1.00 29.45 ?  13   GLN D CG  1 
ATOM   5831 C CD  . GLN D 2 13  ? -21.344 -35.595 -28.661 1.00 36.72 ?  13   GLN D CD  1 
ATOM   5832 O OE1 . GLN D 2 13  ? -21.387 -34.479 -29.192 1.00 38.11 ?  13   GLN D OE1 1 
ATOM   5833 N NE2 . GLN D 2 13  ? -21.796 -36.696 -29.263 1.00 39.04 ?  13   GLN D NE2 1 
ATOM   5834 N N   . ALA D 2 14  ? -19.193 -35.323 -24.285 1.00 16.60 ?  14   ALA D N   1 
ATOM   5835 C CA  . ALA D 2 14  ? -17.875 -34.746 -24.081 1.00 16.73 ?  14   ALA D CA  1 
ATOM   5836 C C   . ALA D 2 14  ? -17.579 -33.696 -25.145 1.00 16.70 ?  14   ALA D C   1 
ATOM   5837 O O   . ALA D 2 14  ? -17.878 -33.862 -26.339 1.00 17.00 ?  14   ALA D O   1 
ATOM   5838 C CB  . ALA D 2 14  ? -16.789 -35.817 -24.078 1.00 18.79 ?  14   ALA D CB  1 
ATOM   5839 N N   . GLY D 2 15  ? -16.962 -32.615 -24.702 1.00 12.95 ?  15   GLY D N   1 
ATOM   5840 C CA  . GLY D 2 15  ? -16.696 -31.483 -25.559 1.00 12.86 ?  15   GLY D CA  1 
ATOM   5841 C C   . GLY D 2 15  ? -17.858 -30.522 -25.680 1.00 16.39 ?  15   GLY D C   1 
ATOM   5842 O O   . GLY D 2 15  ? -17.678 -29.411 -26.214 1.00 14.64 ?  15   GLY D O   1 
ATOM   5843 N N   . GLY D 2 16  ? -19.040 -30.911 -25.188 1.00 15.19 ?  16   GLY D N   1 
ATOM   5844 C CA  . GLY D 2 16  ? -20.210 -30.057 -25.228 1.00 14.89 ?  16   GLY D CA  1 
ATOM   5845 C C   . GLY D 2 16  ? -20.228 -28.970 -24.153 1.00 16.15 ?  16   GLY D C   1 
ATOM   5846 O O   . GLY D 2 16  ? -19.272 -28.753 -23.399 1.00 14.78 ?  16   GLY D O   1 
ATOM   5847 N N   . SER D 2 17  ? -21.340 -28.242 -24.127 1.00 15.08 ?  17   SER D N   1 
ATOM   5848 C CA  . SER D 2 17  ? -21.471 -27.103 -23.227 1.00 13.06 ?  17   SER D CA  1 
ATOM   5849 C C   . SER D 2 17  ? -22.878 -27.063 -22.653 1.00 15.06 ?  17   SER D C   1 
ATOM   5850 O O   . SER D 2 17  ? -23.829 -27.632 -23.210 1.00 16.17 ?  17   SER D O   1 
ATOM   5851 C CB  . SER D 2 17  ? -21.170 -25.788 -23.930 1.00 18.47 ?  17   SER D CB  1 
ATOM   5852 O OG  . SER D 2 17  ? -22.202 -25.542 -24.823 1.00 21.70 ?  17   SER D OG  1 
ATOM   5853 N N   . LEU D 2 18  ? -22.992 -26.405 -21.505 1.00 12.56 ?  18   LEU D N   1 
ATOM   5854 C CA  . LEU D 2 18  ? -24.319 -26.206 -20.925 1.00 14.72 ?  18   LEU D CA  1 
ATOM   5855 C C   . LEU D 2 18  ? -24.214 -25.110 -19.893 1.00 14.64 ?  18   LEU D C   1 
ATOM   5856 O O   . LEU D 2 18  ? -23.124 -24.785 -19.418 1.00 14.07 ?  18   LEU D O   1 
ATOM   5857 C CB  . LEU D 2 18  ? -24.889 -27.488 -20.307 1.00 18.43 ?  18   LEU D CB  1 
ATOM   5858 C CG  . LEU D 2 18  ? -24.198 -28.057 -19.083 1.00 16.15 ?  18   LEU D CG  1 
ATOM   5859 C CD1 . LEU D 2 18  ? -24.512 -27.279 -17.797 1.00 17.61 ?  18   LEU D CD1 1 
ATOM   5860 C CD2 . LEU D 2 18  ? -24.531 -29.557 -18.901 1.00 22.84 ?  18   LEU D CD2 1 
ATOM   5861 N N   . ARG D 2 19  ? -25.362 -24.551 -19.531 1.00 12.38 ?  19   ARG D N   1 
ATOM   5862 C CA  . ARG D 2 19  ? -25.431 -23.462 -18.570 1.00 12.02 ?  19   ARG D CA  1 
ATOM   5863 C C   . ARG D 2 19  ? -26.291 -23.873 -17.390 1.00 13.13 ?  19   ARG D C   1 
ATOM   5864 O O   . ARG D 2 19  ? -27.431 -24.327 -17.571 1.00 15.87 ?  19   ARG D O   1 
ATOM   5865 C CB  . ARG D 2 19  ? -25.993 -22.183 -19.214 1.00 12.90 ?  19   ARG D CB  1 
ATOM   5866 C CG  . ARG D 2 19  ? -25.780 -20.935 -18.346 1.00 14.45 ?  19   ARG D CG  1 
ATOM   5867 C CD  . ARG D 2 19  ? -26.592 -19.706 -18.816 1.00 18.47 ?  19   ARG D CD  1 
ATOM   5868 N NE  . ARG D 2 19  ? -28.023 -19.925 -18.696 1.00 23.92 ?  19   ARG D NE  1 
ATOM   5869 C CZ  . ARG D 2 19  ? -28.920 -18.965 -18.859 1.00 24.44 ?  19   ARG D CZ  1 
ATOM   5870 N NH1 . ARG D 2 19  ? -28.557 -17.740 -19.195 1.00 26.78 ?  19   ARG D NH1 1 
ATOM   5871 N NH2 . ARG D 2 19  ? -30.207 -19.246 -18.676 1.00 31.76 ?  19   ARG D NH2 1 
ATOM   5872 N N   . LEU D 2 20  ? -25.749 -23.712 -16.178 1.00 9.04  ?  20   LEU D N   1 
ATOM   5873 C CA  . LEU D 2 20  ? -26.512 -23.943 -14.957 1.00 9.15  ?  20   LEU D CA  1 
ATOM   5874 C C   . LEU D 2 20  ? -27.009 -22.618 -14.395 1.00 10.91 ?  20   LEU D C   1 
ATOM   5875 O O   . LEU D 2 20  ? -26.381 -21.573 -14.568 1.00 9.76  ?  20   LEU D O   1 
ATOM   5876 C CB  . LEU D 2 20  ? -25.648 -24.625 -13.890 1.00 8.75  ?  20   LEU D CB  1 
ATOM   5877 C CG  . LEU D 2 20  ? -24.992 -25.940 -14.318 1.00 9.03  ?  20   LEU D CG  1 
ATOM   5878 C CD1 . LEU D 2 20  ? -24.237 -26.532 -13.090 1.00 10.31 ?  20   LEU D CD1 1 
ATOM   5879 C CD2 . LEU D 2 20  ? -26.023 -26.906 -14.904 1.00 10.59 ?  20   LEU D CD2 1 
ATOM   5880 N N   . SER D 2 21  ? -28.148 -22.666 -13.702 1.00 9.85  ?  21   SER D N   1 
ATOM   5881 C CA  . SER D 2 21  ? -28.679 -21.498 -12.997 1.00 9.37  ?  21   SER D CA  1 
ATOM   5882 C C   . SER D 2 21  ? -28.834 -21.822 -11.527 1.00 9.56  ?  21   SER D C   1 
ATOM   5883 O O   . SER D 2 21  ? -29.126 -22.968 -11.172 1.00 10.86 ?  21   SER D O   1 
ATOM   5884 C CB  . SER D 2 21  ? -30.109 -21.107 -13.514 1.00 14.87 ?  21   SER D CB  1 
ATOM   5885 O OG  . SER D 2 21  ? -30.104 -20.820 -14.904 1.00 17.97 ?  21   SER D OG  1 
ATOM   5886 N N   . CYS D 2 22  ? -28.765 -20.782 -10.672 1.00 7.29  ?  22   CYS D N   1 
ATOM   5887 C CA  . CYS D 2 22  ? -29.012 -20.906 -9.229  1.00 11.64 ?  22   CYS D CA  1 
ATOM   5888 C C   . CYS D 2 22  ? -29.810 -19.695 -8.766  1.00 13.72 ?  22   CYS D C   1 
ATOM   5889 O O   . CYS D 2 22  ? -29.328 -18.573 -8.848  1.00 12.97 ?  22   CYS D O   1 
ATOM   5890 C CB  . CYS D 2 22  ? -27.693 -21.019 -8.469  1.00 13.06 ?  22   CYS D CB  1 
ATOM   5891 S SG  . CYS D 2 22  ? -27.938 -21.651 -6.728  1.00 26.27 ?  22   CYS D SG  1 
ATOM   5892 N N   . ALA D 2 23  ? -31.060 -19.910 -8.350  1.00 10.44 ?  23   ALA D N   1 
ATOM   5893 C CA  . ALA D 2 23  ? -31.867 -18.846 -7.749  1.00 14.05 ?  23   ALA D CA  1 
ATOM   5894 C C   . ALA D 2 23  ? -31.640 -18.798 -6.243  1.00 12.44 ?  23   ALA D C   1 
ATOM   5895 O O   . ALA D 2 23  ? -31.773 -19.803 -5.542  1.00 12.77 ?  23   ALA D O   1 
ATOM   5896 C CB  . ALA D 2 23  ? -33.352 -19.078 -8.070  1.00 15.23 ?  23   ALA D CB  1 
ATOM   5897 N N   . ALA D 2 24  ? -31.287 -17.624 -5.732  1.00 12.67 ?  24   ALA D N   1 
ATOM   5898 C CA  . ALA D 2 24  ? -30.949 -17.460 -4.321  1.00 12.04 ?  24   ALA D CA  1 
ATOM   5899 C C   . ALA D 2 24  ? -31.876 -16.420 -3.732  1.00 19.46 ?  24   ALA D C   1 
ATOM   5900 O O   . ALA D 2 24  ? -31.780 -15.235 -4.081  1.00 22.15 ?  24   ALA D O   1 
ATOM   5901 C CB  . ALA D 2 24  ? -29.481 -17.046 -4.148  1.00 16.42 ?  24   ALA D CB  1 
ATOM   5902 N N   . SER D 2 25  ? -32.760 -16.849 -2.846  1.00 16.52 ?  25   SER D N   1 
ATOM   5903 C CA  . SER D 2 25  ? -33.768 -15.960 -2.302  1.00 22.00 ?  25   SER D CA  1 
ATOM   5904 C C   . SER D 2 25  ? -33.632 -15.894 -0.789  1.00 19.04 ?  25   SER D C   1 
ATOM   5905 O O   . SER D 2 25  ? -32.889 -16.654 -0.162  1.00 18.83 ?  25   SER D O   1 
ATOM   5906 C CB  . SER D 2 25  ? -35.158 -16.432 -2.680  1.00 20.17 ?  25   SER D CB  1 
ATOM   5907 O OG  . SER D 2 25  ? -35.384 -17.765 -2.259  1.00 21.85 ?  25   SER D OG  1 
ATOM   5908 N N   . GLY D 2 26  ? -34.362 -14.957 -0.190  1.00 21.84 ?  26   GLY D N   1 
ATOM   5909 C CA  . GLY D 2 26  ? -34.255 -14.818 1.253   1.00 20.87 ?  26   GLY D CA  1 
ATOM   5910 C C   . GLY D 2 26  ? -33.094 -14.008 1.772   1.00 23.89 ?  26   GLY D C   1 
ATOM   5911 O O   . GLY D 2 26  ? -32.887 -13.977 2.996   1.00 24.55 ?  26   GLY D O   1 
ATOM   5912 N N   . THR D 2 27  ? -32.329 -13.335 0.909   1.00 23.21 ?  27   THR D N   1 
ATOM   5913 C CA  . THR D 2 27  ? -31.243 -12.480 1.370   1.00 22.33 ?  27   THR D CA  1 
ATOM   5914 C C   . THR D 2 27  ? -31.285 -11.172 0.569   1.00 20.82 ?  27   THR D C   1 
ATOM   5915 O O   . THR D 2 27  ? -32.207 -10.938 -0.235  1.00 20.68 ?  27   THR D O   1 
ATOM   5916 C CB  . THR D 2 27  ? -29.886 -13.224 1.274   1.00 28.49 ?  27   THR D CB  1 
ATOM   5917 O OG1 . THR D 2 27  ? -28.939 -12.631 2.165   1.00 37.22 ?  27   THR D OG1 1 
ATOM   5918 C CG2 . THR D 2 27  ? -29.360 -13.198 -0.080  1.00 24.02 ?  27   THR D CG2 1 
ATOM   5919 N N   . ILE D 2 28  ? -30.316 -10.294 0.820   1.00 20.72 ?  28   ILE D N   1 
ATOM   5920 C CA  . ILE D 2 28  ? -30.153 -9.068  0.034   1.00 20.50 ?  28   ILE D CA  1 
ATOM   5921 C C   . ILE D 2 28  ? -29.175 -9.442  -1.074  1.00 17.45 ?  28   ILE D C   1 
ATOM   5922 O O   . ILE D 2 28  ? -27.952 -9.347  -0.934  1.00 16.33 ?  28   ILE D O   1 
ATOM   5923 C CB  . ILE D 2 28  ? -29.662 -7.904  0.876   1.00 21.27 ?  28   ILE D CB  1 
ATOM   5924 C CG1 . ILE D 2 28  ? -30.709 -7.589  1.950   1.00 27.12 ?  28   ILE D CG1 1 
ATOM   5925 C CG2 . ILE D 2 28  ? -29.540 -6.675  -0.021  1.00 19.86 ?  28   ILE D CG2 1 
ATOM   5926 C CD1 . ILE D 2 28  ? -30.337 -6.395  2.822   1.00 32.87 ?  28   ILE D CD1 1 
ATOM   5927 N N   . PHE D 2 29  ? -29.722 -9.939  -2.172  1.00 17.19 ?  29   PHE D N   1 
ATOM   5928 C CA  . PHE D 2 29  ? -28.885 -10.575 -3.202  1.00 16.00 ?  29   PHE D CA  1 
ATOM   5929 C C   . PHE D 2 29  ? -27.753 -9.674  -3.678  1.00 15.56 ?  29   PHE D C   1 
ATOM   5930 O O   . PHE D 2 29  ? -26.610 -10.115 -3.848  1.00 14.01 ?  29   PHE D O   1 
ATOM   5931 C CB  . PHE D 2 29  ? -29.753 -10.933 -4.392  1.00 14.53 ?  29   PHE D CB  1 
ATOM   5932 C CG  . PHE D 2 29  ? -29.051 -11.739 -5.442  1.00 14.52 ?  29   PHE D CG  1 
ATOM   5933 C CD1 . PHE D 2 29  ? -29.000 -13.121 -5.372  1.00 13.14 ?  29   PHE D CD1 1 
ATOM   5934 C CD2 . PHE D 2 29  ? -28.412 -11.091 -6.510  1.00 13.83 ?  29   PHE D CD2 1 
ATOM   5935 C CE1 . PHE D 2 29  ? -28.367 -13.860 -6.385  1.00 14.10 ?  29   PHE D CE1 1 
ATOM   5936 C CE2 . PHE D 2 29  ? -27.770 -11.829 -7.549  1.00 13.79 ?  29   PHE D CE2 1 
ATOM   5937 C CZ  . PHE D 2 29  ? -27.747 -13.216 -7.473  1.00 11.81 ?  29   PHE D CZ  1 
ATOM   5938 N N   . SER D 2 30  ? -28.054 -8.400  -3.920  1.00 13.88 ?  30   SER D N   1 
ATOM   5939 C CA  . SER D 2 30  ? -27.061 -7.526  -4.533  1.00 15.55 ?  30   SER D CA  1 
ATOM   5940 C C   . SER D 2 30  ? -25.832 -7.273  -3.668  1.00 17.44 ?  30   SER D C   1 
ATOM   5941 O O   . SER D 2 30  ? -24.812 -6.826  -4.209  1.00 17.05 ?  30   SER D O   1 
ATOM   5942 C CB  . SER D 2 30  ? -27.722 -6.182  -4.887  1.00 18.37 ?  30   SER D CB  1 
ATOM   5943 O OG  . SER D 2 30  ? -28.038 -5.487  -3.683  1.00 19.95 ?  30   SER D OG  1 
ATOM   5944 N N   . ILE D 2 31  ? -25.873 -7.535  -2.353  1.00 15.33 ?  31   ILE D N   1 
ATOM   5945 C CA  . ILE D 2 31  ? -24.668 -7.304  -1.540  1.00 14.38 ?  31   ILE D CA  1 
ATOM   5946 C C   . ILE D 2 31  ? -23.912 -8.598  -1.255  1.00 19.38 ?  31   ILE D C   1 
ATOM   5947 O O   . ILE D 2 31  ? -22.816 -8.540  -0.668  1.00 19.76 ?  31   ILE D O   1 
ATOM   5948 C CB  . ILE D 2 31  ? -24.952 -6.597  -0.196  1.00 21.92 ?  31   ILE D CB  1 
ATOM   5949 C CG1 . ILE D 2 31  ? -25.909 -7.386  0.669   1.00 20.95 ?  31   ILE D CG1 1 
ATOM   5950 C CG2 . ILE D 2 31  ? -25.501 -5.215  -0.494  1.00 21.73 ?  31   ILE D CG2 1 
ATOM   5951 C CD1 . ILE D 2 31  ? -26.268 -6.685  2.016   1.00 30.25 ?  31   ILE D CD1 1 
ATOM   5952 N N   . ASP D 2 32  ? -24.450 -9.745  -1.664  1.00 12.66 ?  32   ASP D N   1 
ATOM   5953 C CA  . ASP D 2 32  ? -23.819 -11.050 -1.426  1.00 14.26 ?  32   ASP D CA  1 
ATOM   5954 C C   . ASP D 2 32  ? -22.832 -11.420 -2.528  1.00 13.17 ?  32   ASP D C   1 
ATOM   5955 O O   . ASP D 2 32  ? -23.025 -11.064 -3.697  1.00 12.63 ?  32   ASP D O   1 
ATOM   5956 C CB  . ASP D 2 32  ? -24.874 -12.147 -1.374  1.00 13.29 ?  32   ASP D CB  1 
ATOM   5957 C CG  . ASP D 2 32  ? -25.693 -12.151 -0.069  1.00 13.78 ?  32   ASP D CG  1 
ATOM   5958 O OD1 . ASP D 2 32  ? -25.324 -11.485 0.942   1.00 17.97 ?  32   ASP D OD1 1 
ATOM   5959 O OD2 . ASP D 2 32  ? -26.702 -12.859 -0.075  1.00 18.23 -1 32   ASP D OD2 1 
ATOM   5960 N N   . ALA D 2 33  ? -21.797 -12.205 -2.156  1.00 11.51 ?  33   ALA D N   1 
ATOM   5961 C CA  . ALA D 2 33  ? -20.941 -12.908 -3.106  1.00 7.90  ?  33   ALA D CA  1 
ATOM   5962 C C   . ALA D 2 33  ? -21.423 -14.357 -3.198  1.00 7.16  ?  33   ALA D C   1 
ATOM   5963 O O   . ALA D 2 33  ? -22.055 -14.867 -2.259  1.00 8.85  ?  33   ALA D O   1 
ATOM   5964 C CB  . ALA D 2 33  ? -19.460 -12.907 -2.665  1.00 10.99 ?  33   ALA D CB  1 
ATOM   5965 N N   . PHE D 2 34  ? -21.155 -15.001 -4.334  1.00 8.47  ?  34   PHE D N   1 
ATOM   5966 C CA  . PHE D 2 34  ? -21.636 -16.381 -4.509  1.00 8.48  ?  34   PHE D CA  1 
ATOM   5967 C C   . PHE D 2 34  ? -20.532 -17.265 -5.042  1.00 8.25  ?  34   PHE D C   1 
ATOM   5968 O O   . PHE D 2 34  ? -19.597 -16.814 -5.717  1.00 10.09 ?  34   PHE D O   1 
ATOM   5969 C CB  . PHE D 2 34  ? -22.848 -16.415 -5.486  1.00 8.17  ?  34   PHE D CB  1 
ATOM   5970 C CG  . PHE D 2 34  ? -24.076 -15.804 -4.898  1.00 8.56  ?  34   PHE D CG  1 
ATOM   5971 C CD1 . PHE D 2 34  ? -24.913 -16.548 -4.113  1.00 9.50  ?  34   PHE D CD1 1 
ATOM   5972 C CD2 . PHE D 2 34  ? -24.348 -14.441 -5.081  1.00 10.58 ?  34   PHE D CD2 1 
ATOM   5973 C CE1 . PHE D 2 34  ? -26.050 -15.995 -3.510  1.00 10.83 ?  34   PHE D CE1 1 
ATOM   5974 C CE2 . PHE D 2 34  ? -25.447 -13.866 -4.477  1.00 12.05 ?  34   PHE D CE2 1 
ATOM   5975 C CZ  . PHE D 2 34  ? -26.317 -14.637 -3.716  1.00 12.70 ?  34   PHE D CZ  1 
ATOM   5976 N N   . GLY D 2 35  ? -20.677 -18.576 -4.799  1.00 7.44  ?  35   GLY D N   1 
ATOM   5977 C CA  . GLY D 2 35  ? -19.761 -19.550 -5.375  1.00 8.40  ?  35   GLY D CA  1 
ATOM   5978 C C   . GLY D 2 35  ? -20.556 -20.679 -6.004  1.00 7.73  ?  35   GLY D C   1 
ATOM   5979 O O   . GLY D 2 35  ? -21.709 -20.924 -5.636  1.00 7.93  ?  35   GLY D O   1 
ATOM   5980 N N   . TRP D 2 36  ? -19.905 -21.375 -6.957  1.00 6.87  ?  36   TRP D N   1 
ATOM   5981 C CA  . TRP D 2 36  ? -20.331 -22.678 -7.450  1.00 7.62  ?  36   TRP D CA  1 
ATOM   5982 C C   . TRP D 2 36  ? -19.342 -23.727 -6.947  1.00 7.54  ?  36   TRP D C   1 
ATOM   5983 O O   . TRP D 2 36  ? -18.130 -23.461 -6.896  1.00 8.27  ?  36   TRP D O   1 
ATOM   5984 C CB  . TRP D 2 36  ? -20.370 -22.736 -8.978  1.00 7.23  ?  36   TRP D CB  1 
ATOM   5985 C CG  . TRP D 2 36  ? -21.624 -22.126 -9.552  1.00 7.88  ?  36   TRP D CG  1 
ATOM   5986 C CD1 . TRP D 2 36  ? -21.772 -20.840 -10.001 1.00 8.16  ?  36   TRP D CD1 1 
ATOM   5987 C CD2 . TRP D 2 36  ? -22.894 -22.786 -9.760  1.00 7.57  ?  36   TRP D CD2 1 
ATOM   5988 N NE1 . TRP D 2 36  ? -23.093 -20.639 -10.431 1.00 10.03 ?  36   TRP D NE1 1 
ATOM   5989 C CE2 . TRP D 2 36  ? -23.782 -21.816 -10.333 1.00 7.52  ?  36   TRP D CE2 1 
ATOM   5990 C CE3 . TRP D 2 36  ? -23.358 -24.083 -9.501  1.00 7.54  ?  36   TRP D CE3 1 
ATOM   5991 C CZ2 . TRP D 2 36  ? -25.126 -22.122 -10.671 1.00 8.54  ?  36   TRP D CZ2 1 
ATOM   5992 C CZ3 . TRP D 2 36  ? -24.691 -24.404 -9.849  1.00 10.40 ?  36   TRP D CZ3 1 
ATOM   5993 C CH2 . TRP D 2 36  ? -25.564 -23.407 -10.420 1.00 10.13 ?  36   TRP D CH2 1 
ATOM   5994 N N   . TYR D 2 37  ? -19.876 -24.899 -6.607  1.00 6.51  ?  37   TYR D N   1 
ATOM   5995 C CA  . TYR D 2 37  ? -19.180 -26.023 -5.994  1.00 6.18  ?  37   TYR D CA  1 
ATOM   5996 C C   . TYR D 2 37  ? -19.678 -27.284 -6.690  1.00 6.30  ?  37   TYR D C   1 
ATOM   5997 O O   . TYR D 2 37  ? -20.739 -27.274 -7.316  1.00 7.96  ?  37   TYR D O   1 
ATOM   5998 C CB  . TYR D 2 37  ? -19.497 -26.122 -4.459  1.00 6.38  ?  37   TYR D CB  1 
ATOM   5999 C CG  . TYR D 2 37  ? -19.258 -24.814 -3.738  1.00 6.86  ?  37   TYR D CG  1 
ATOM   6000 C CD1 . TYR D 2 37  ? -20.197 -23.753 -3.829  1.00 7.05  ?  37   TYR D CD1 1 
ATOM   6001 C CD2 . TYR D 2 37  ? -18.079 -24.613 -2.987  1.00 7.31  ?  37   TYR D CD2 1 
ATOM   6002 C CE1 . TYR D 2 37  ? -19.944 -22.538 -3.194  1.00 6.99  ?  37   TYR D CE1 1 
ATOM   6003 C CE2 . TYR D 2 37  ? -17.838 -23.394 -2.357  1.00 6.74  ?  37   TYR D CE2 1 
ATOM   6004 C CZ  . TYR D 2 37  ? -18.776 -22.387 -2.470  1.00 7.89  ?  37   TYR D CZ  1 
ATOM   6005 O OH  . TYR D 2 37  ? -18.569 -21.164 -1.868  1.00 8.66  ?  37   TYR D OH  1 
ATOM   6006 N N   . ARG D 2 38  ? -18.923 -28.386 -6.571  1.00 6.63  ?  38   ARG D N   1 
ATOM   6007 C CA  . ARG D 2 38  ? -19.363 -29.663 -7.142  1.00 7.02  ?  38   ARG D CA  1 
ATOM   6008 C C   . ARG D 2 38  ? -18.891 -30.832 -6.282  1.00 7.56  ?  38   ARG D C   1 
ATOM   6009 O O   . ARG D 2 38  ? -17.862 -30.744 -5.578  1.00 7.91  ?  38   ARG D O   1 
ATOM   6010 C CB  . ARG D 2 38  ? -18.876 -29.837 -8.608  1.00 7.38  ?  38   ARG D CB  1 
ATOM   6011 C CG  . ARG D 2 38  ? -17.379 -30.047 -8.737  1.00 7.07  ?  38   ARG D CG  1 
ATOM   6012 C CD  . ARG D 2 38  ? -17.059 -30.066 -10.223 1.00 7.61  ?  38   ARG D CD  1 
ATOM   6013 N NE  . ARG D 2 38  ? -15.638 -30.372 -10.406 1.00 8.58  ?  38   ARG D NE  1 
ATOM   6014 C CZ  . ARG D 2 38  ? -15.053 -30.376 -11.599 1.00 10.71 ?  38   ARG D CZ  1 
ATOM   6015 N NH1 . ARG D 2 38  ? -15.709 -29.966 -12.698 1.00 9.24  ?  38   ARG D NH1 1 
ATOM   6016 N NH2 . ARG D 2 38  ? -13.790 -30.807 -11.696 1.00 10.25 ?  38   ARG D NH2 1 
ATOM   6017 N N   . GLN D 2 39  ? -19.647 -31.940 -6.343  1.00 7.61  ?  39   GLN D N   1 
ATOM   6018 C CA  . GLN D 2 39  ? -19.254 -33.148 -5.610  1.00 7.99  ?  39   GLN D CA  1 
ATOM   6019 C C   . GLN D 2 39  ? -19.654 -34.359 -6.396  1.00 11.85 ?  39   GLN D C   1 
ATOM   6020 O O   . GLN D 2 39  ? -20.838 -34.520 -6.716  1.00 12.19 ?  39   GLN D O   1 
ATOM   6021 C CB  . GLN D 2 39  ? -19.875 -33.213 -4.201  1.00 8.68  ?  39   GLN D CB  1 
ATOM   6022 C CG  . GLN D 2 39  ? -19.258 -34.324 -3.300  1.00 11.38 ?  39   GLN D CG  1 
ATOM   6023 C CD  . GLN D 2 39  ? -19.706 -34.188 -1.843  1.00 14.25 ?  39   GLN D CD  1 
ATOM   6024 O OE1 . GLN D 2 39  ? -20.733 -33.606 -1.545  1.00 15.96 ?  39   GLN D OE1 1 
ATOM   6025 N NE2 . GLN D 2 39  ? -18.900 -34.724 -0.934  1.00 18.18 ?  39   GLN D NE2 1 
ATOM   6026 N N   . ALA D 2 40  ? -18.704 -35.237 -6.586  1.00 10.45 ?  40   ALA D N   1 
ATOM   6027 C CA  . ALA D 2 40  ? -18.937 -36.516 -7.262  1.00 14.06 ?  40   ALA D CA  1 
ATOM   6028 C C   . ALA D 2 40  ? -19.062 -37.621 -6.218  1.00 18.22 ?  40   ALA D C   1 
ATOM   6029 O O   . ALA D 2 40  ? -18.535 -37.492 -5.110  1.00 14.53 ?  40   ALA D O   1 
ATOM   6030 C CB  . ALA D 2 40  ? -17.779 -36.813 -8.224  1.00 15.44 ?  40   ALA D CB  1 
ATOM   6031 N N   . PRO D 2 41  ? -19.769 -38.715 -6.497  1.00 20.69 ?  41   PRO D N   1 
ATOM   6032 C CA  . PRO D 2 41  ? -19.955 -39.757 -5.465  1.00 18.87 ?  41   PRO D CA  1 
ATOM   6033 C C   . PRO D 2 41  ? -18.616 -40.275 -4.940  1.00 19.28 ?  41   PRO D C   1 
ATOM   6034 O O   . PRO D 2 41  ? -17.680 -40.527 -5.704  1.00 19.87 ?  41   PRO D O   1 
ATOM   6035 C CB  . PRO D 2 41  ? -20.737 -40.846 -6.211  1.00 24.15 ?  41   PRO D CB  1 
ATOM   6036 C CG  . PRO D 2 41  ? -21.523 -40.053 -7.257  1.00 27.26 ?  41   PRO D CG  1 
ATOM   6037 C CD  . PRO D 2 41  ? -20.529 -39.001 -7.729  1.00 23.52 ?  41   PRO D CD  1 
ATOM   6038 N N   . GLY D 2 42  ? -18.511 -40.346 -3.614  1.00 21.31 ?  42   GLY D N   1 
ATOM   6039 C CA  . GLY D 2 42  ? -17.301 -40.856 -2.996  1.00 23.16 ?  42   GLY D CA  1 
ATOM   6040 C C   . GLY D 2 42  ? -16.109 -39.921 -2.993  1.00 26.36 ?  42   GLY D C   1 
ATOM   6041 O O   . GLY D 2 42  ? -15.008 -40.351 -2.612  1.00 24.34 ?  42   GLY D O   1 
ATOM   6042 N N   . LYS D 2 43  ? -16.274 -38.662 -3.408  1.00 18.33 ?  43   LYS D N   1 
ATOM   6043 C CA  . LYS D 2 43  ? -15.179 -37.696 -3.397  1.00 17.11 ?  43   LYS D CA  1 
ATOM   6044 C C   . LYS D 2 43  ? -15.545 -36.503 -2.517  1.00 13.35 ?  43   LYS D C   1 
ATOM   6045 O O   . LYS D 2 43  ? -16.698 -36.295 -2.179  1.00 13.23 ?  43   LYS D O   1 
ATOM   6046 C CB  . LYS D 2 43  ? -14.841 -37.189 -4.797  1.00 19.25 ?  43   LYS D CB  1 
ATOM   6047 C CG  . LYS D 2 43  ? -14.607 -38.301 -5.881  1.00 25.44 ?  43   LYS D CG  1 
ATOM   6048 C CD  . LYS D 2 43  ? -13.139 -38.427 -6.230  1.00 33.73 ?  43   LYS D CD  1 
ATOM   6049 C CE  . LYS D 2 43  ? -12.756 -39.810 -6.760  1.00 50.80 ?  43   LYS D CE  1 
ATOM   6050 N NZ  . LYS D 2 43  ? -11.599 -40.401 -6.010  1.00 61.64 ?  43   LYS D NZ  1 
ATOM   6051 N N   . GLN D 2 44  ? -14.526 -35.718 -2.148  1.00 12.25 ?  44   GLN D N   1 
ATOM   6052 C CA  . GLN D 2 44  ? -14.758 -34.496 -1.375  1.00 10.79 ?  44   GLN D CA  1 
ATOM   6053 C C   . GLN D 2 44  ? -15.421 -33.424 -2.238  1.00 10.17 ?  44   GLN D C   1 
ATOM   6054 O O   . GLN D 2 44  ? -15.123 -33.312 -3.440  1.00 10.64 ?  44   GLN D O   1 
ATOM   6055 C CB  . GLN D 2 44  ? -13.426 -33.978 -0.813  1.00 10.56 ?  44   GLN D CB  1 
ATOM   6056 C CG  . GLN D 2 44  ? -12.730 -35.046 0.070   1.00 9.31  ?  44   GLN D CG  1 
ATOM   6057 C CD  . GLN D 2 44  ? -13.275 -35.108 1.518   1.00 10.16 ?  44   GLN D CD  1 
ATOM   6058 O OE1 . GLN D 2 44  ? -14.237 -34.429 1.883   1.00 8.72  ?  44   GLN D OE1 1 
ATOM   6059 N NE2 . GLN D 2 44  ? -12.613 -35.937 2.367   1.00 10.64 ?  44   GLN D NE2 1 
ATOM   6060 N N   . ARG D 2 45  ? -16.223 -32.552 -1.587  1.00 6.76  ?  45   ARG D N   1 
ATOM   6061 C CA  . ARG D 2 45  ? -16.839 -31.436 -2.336  1.00 7.91  ?  45   ARG D CA  1 
ATOM   6062 C C   . ARG D 2 45  ? -15.737 -30.403 -2.633  1.00 9.83  ?  45   ARG D C   1 
ATOM   6063 O O   . ARG D 2 45  ? -14.808 -30.213 -1.833  1.00 9.97  ?  45   ARG D O   1 
ATOM   6064 C CB  . ARG D 2 45  ? -17.948 -30.788 -1.485  1.00 8.93  ?  45   ARG D CB  1 
ATOM   6065 C CG  . ARG D 2 45  ? -18.631 -29.652 -2.218  1.00 7.98  ?  45   ARG D CG  1 
ATOM   6066 C CD  . ARG D 2 45  ? -20.117 -29.548 -1.871  1.00 13.33 ?  45   ARG D CD  1 
ATOM   6067 N NE  . ARG D 2 45  ? -20.430 -29.883 -0.501  1.00 19.08 ?  45   ARG D NE  1 
ATOM   6068 C CZ  . ARG D 2 45  ? -21.633 -30.260 -0.077  1.00 19.12 ?  45   ARG D CZ  1 
ATOM   6069 N NH1 . ARG D 2 45  ? -22.666 -30.367 -0.924  1.00 16.09 ?  45   ARG D NH1 1 
ATOM   6070 N NH2 . ARG D 2 45  ? -21.804 -30.542 1.226   1.00 20.79 ?  45   ARG D NH2 1 
ATOM   6071 N N   . GLU D 2 46  ? -15.816 -29.752 -3.800  1.00 6.98  ?  46   GLU D N   1 
ATOM   6072 C CA  . GLU D 2 46  ? -14.786 -28.774 -4.181  1.00 8.47  ?  46   GLU D CA  1 
ATOM   6073 C C   . GLU D 2 46  ? -15.410 -27.526 -4.805  1.00 7.32  ?  46   GLU D C   1 
ATOM   6074 O O   . GLU D 2 46  ? -16.468 -27.561 -5.468  1.00 9.21  ?  46   GLU D O   1 
ATOM   6075 C CB  . GLU D 2 46  ? -13.796 -29.432 -5.135  1.00 8.52  ?  46   GLU D CB  1 
ATOM   6076 C CG  . GLU D 2 46  ? -14.335 -29.821 -6.502  1.00 8.83  ?  46   GLU D CG  1 
ATOM   6077 C CD  . GLU D 2 46  ? -13.322 -30.600 -7.344  1.00 12.58 ?  46   GLU D CD  1 
ATOM   6078 O OE1 . GLU D 2 46  ? -12.092 -30.686 -6.974  1.00 12.53 ?  46   GLU D OE1 1 
ATOM   6079 O OE2 . GLU D 2 46  ? -13.785 -31.161 -8.385  1.00 10.03 -1 46   GLU D OE2 1 
ATOM   6080 N N   . TRP D 2 47  ? -14.743 -26.412 -4.578  1.00 6.50  ?  47   TRP D N   1 
ATOM   6081 C CA  . TRP D 2 47  ? -15.139 -25.120 -5.139  1.00 7.78  ?  47   TRP D CA  1 
ATOM   6082 C C   . TRP D 2 47  ? -14.668 -25.010 -6.590  1.00 7.30  ?  47   TRP D C   1 
ATOM   6083 O O   . TRP D 2 47  ? -13.596 -25.491 -6.936  1.00 8.47  ?  47   TRP D O   1 
ATOM   6084 C CB  . TRP D 2 47  ? -14.493 -24.007 -4.281  1.00 8.16  ?  47   TRP D CB  1 
ATOM   6085 C CG  . TRP D 2 47  ? -14.592 -22.632 -4.897  1.00 7.61  ?  47   TRP D CG  1 
ATOM   6086 C CD1 . TRP D 2 47  ? -15.665 -21.785 -4.824  1.00 8.90  ?  47   TRP D CD1 1 
ATOM   6087 C CD2 . TRP D 2 47  ? -13.571 -21.946 -5.621  1.00 8.29  ?  47   TRP D CD2 1 
ATOM   6088 N NE1 . TRP D 2 47  ? -15.381 -20.588 -5.496  1.00 7.94  ?  47   TRP D NE1 1 
ATOM   6089 C CE2 . TRP D 2 47  ? -14.098 -20.679 -5.983  1.00 7.51  ?  47   TRP D CE2 1 
ATOM   6090 C CE3 . TRP D 2 47  ? -12.248 -22.276 -6.005  1.00 8.55  ?  47   TRP D CE3 1 
ATOM   6091 C CZ2 . TRP D 2 47  ? -13.341 -19.738 -6.706  1.00 9.65  ?  47   TRP D CZ2 1 
ATOM   6092 C CZ3 . TRP D 2 47  ? -11.503 -21.314 -6.724  1.00 11.35 ?  47   TRP D CZ3 1 
ATOM   6093 C CH2 . TRP D 2 47  ? -12.078 -20.106 -7.095  1.00 9.05  ?  47   TRP D CH2 1 
ATOM   6094 N N   . VAL D 2 48  ? -15.485 -24.375 -7.452  1.00 5.76  ?  48   VAL D N   1 
ATOM   6095 C CA  . VAL D 2 48  ? -15.097 -24.213 -8.866  1.00 8.42  ?  48   VAL D CA  1 
ATOM   6096 C C   . VAL D 2 48  ? -15.054 -22.751 -9.323  1.00 7.41  ?  48   VAL D C   1 
ATOM   6097 O O   . VAL D 2 48  ? -14.265 -22.434 -10.222 1.00 9.38  ?  48   VAL D O   1 
ATOM   6098 C CB  . VAL D 2 48  ? -15.928 -25.054 -9.858  1.00 12.03 ?  48   VAL D CB  1 
ATOM   6099 C CG1 . VAL D 2 48  ? -15.913 -26.572 -9.484  1.00 13.39 ?  48   VAL D CG1 1 
ATOM   6100 C CG2 . VAL D 2 48  ? -17.337 -24.590 -10.013 1.00 13.47 ?  48   VAL D CG2 1 
ATOM   6101 N N   . ALA D 2 49  ? -15.918 -21.879 -8.790  1.00 6.95  ?  49   ALA D N   1 
ATOM   6102 C CA  . ALA D 2 49  ? -15.897 -20.502 -9.300  1.00 8.67  ?  49   ALA D CA  1 
ATOM   6103 C C   . ALA D 2 49  ? -16.545 -19.559 -8.313  1.00 8.32  ?  49   ALA D C   1 
ATOM   6104 O O   . ALA D 2 49  ? -17.434 -19.964 -7.555  1.00 8.30  ?  49   ALA D O   1 
ATOM   6105 C CB  . ALA D 2 49  ? -16.649 -20.453 -10.634 1.00 8.55  ?  49   ALA D CB  1 
ATOM   6106 N N   . GLY D 2 50  ? -16.104 -18.298 -8.305  1.00 8.29  ?  50   GLY D N   1 
ATOM   6107 C CA  . GLY D 2 50  ? -16.647 -17.326 -7.368  1.00 7.51  ?  50   GLY D CA  1 
ATOM   6108 C C   . GLY D 2 50  ? -16.882 -15.975 -8.017  1.00 10.62 ?  50   GLY D C   1 
ATOM   6109 O O   . GLY D 2 50  ? -16.188 -15.604 -8.959  1.00 12.16 ?  50   GLY D O   1 
ATOM   6110 N N   . ILE D 2 51  ? -17.877 -15.242 -7.500  1.00 7.94  ?  51   ILE D N   1 
ATOM   6111 C CA  . ILE D 2 51  ? -18.182 -13.887 -8.003  1.00 9.93  ?  51   ILE D CA  1 
ATOM   6112 C C   . ILE D 2 51  ? -18.515 -12.927 -6.846  1.00 9.22  ?  51   ILE D C   1 
ATOM   6113 O O   . ILE D 2 51  ? -19.298 -13.257 -5.949  1.00 9.56  ?  51   ILE D O   1 
ATOM   6114 C CB  . ILE D 2 51  ? -19.321 -13.929 -9.053  1.00 9.11  ?  51   ILE D CB  1 
ATOM   6115 C CG1 . ILE D 2 51  ? -19.476 -12.547 -9.746  1.00 10.86 ?  51   ILE D CG1 1 
ATOM   6116 C CG2 . ILE D 2 51  ? -20.656 -14.441 -8.479  1.00 10.72 ?  51   ILE D CG2 1 
ATOM   6117 C CD1 . ILE D 2 51  ? -20.340 -12.674 -11.019 1.00 10.26 ?  51   ILE D CD1 1 
ATOM   6118 N N   . THR D 2 52  ? -17.897 -11.719 -6.849  1.00 11.07 ?  52   THR D N   1 
ATOM   6119 C CA  . THR D 2 52  ? -18.141 -10.741 -5.791  1.00 11.31 ?  52   THR D CA  1 
ATOM   6120 C C   . THR D 2 52  ? -19.425 -9.942  -6.072  1.00 14.78 ?  52   THR D C   1 
ATOM   6121 O O   . THR D 2 52  ? -20.009 -10.011 -7.168  1.00 14.55 ?  52   THR D O   1 
ATOM   6122 C CB  . THR D 2 52  ? -16.983 -9.742  -5.658  1.00 14.11 ?  52   THR D CB  1 
ATOM   6123 O OG1 . THR D 2 52  ? -16.929 -8.947  -6.859  1.00 15.74 ?  52   THR D OG1 1 
ATOM   6124 C CG2 . THR D 2 52  ? -15.636 -10.450 -5.467  1.00 15.21 ?  52   THR D CG2 1 
ATOM   6125 N N   . SER D 2 53  ? -19.862 -9.170  -5.069  1.00 13.56 ?  53   SER D N   1 
ATOM   6126 C CA  . SER D 2 53  ? -21.006 -8.273  -5.298  1.00 17.02 ?  53   SER D CA  1 
ATOM   6127 C C   . SER D 2 53  ? -20.703 -7.262  -6.407  1.00 19.07 ?  53   SER D C   1 
ATOM   6128 O O   . SER D 2 53  ? -21.641 -6.739  -7.046  1.00 20.83 ?  53   SER D O   1 
ATOM   6129 C CB  . SER D 2 53  ? -21.394 -7.546  -4.018  1.00 18.72 ?  53   SER D CB  1 
ATOM   6130 O OG  . SER D 2 53  ? -20.292 -6.757  -3.574  1.00 21.84 ?  53   SER D OG  1 
ATOM   6131 N N   . GLY D 2 54  ? -19.427 -7.010  -6.668  1.00 17.25 ?  54   GLY D N   1 
ATOM   6132 C CA  . GLY D 2 54  ? -18.969 -6.148  -7.738  1.00 17.84 ?  54   GLY D CA  1 
ATOM   6133 C C   . GLY D 2 54  ? -18.793 -6.844  -9.064  1.00 20.67 ?  54   GLY D C   1 
ATOM   6134 O O   . GLY D 2 54  ? -18.285 -6.236  -10.011 1.00 20.23 ?  54   GLY D O   1 
ATOM   6135 N N   . SER D 2 55  ? -19.165 -8.126  -9.154  1.00 14.96 ?  55   SER D N   1 
ATOM   6136 C CA  . SER D 2 55  ? -19.094 -8.918  -10.364 1.00 14.88 ?  55   SER D CA  1 
ATOM   6137 C C   . SER D 2 55  ? -17.679 -9.232  -10.798 1.00 16.52 ?  55   SER D C   1 
ATOM   6138 O O   . SER D 2 55  ? -17.480 -9.676  -11.929 1.00 18.46 ?  55   SER D O   1 
ATOM   6139 C CB  . SER D 2 55  ? -19.890 -8.278  -11.519 1.00 19.47 ?  55   SER D CB  1 
ATOM   6140 O OG  . SER D 2 55  ? -21.249 -8.128  -11.157 1.00 18.97 ?  55   SER D OG  1 
ATOM   6141 N N   . SER D 2 56  ? -16.703 -9.143  -9.884  1.00 15.05 ?  56   SER D N   1 
ATOM   6142 C CA  . SER D 2 56  ? -15.365 -9.662  -10.149 1.00 16.44 ?  56   SER D CA  1 
ATOM   6143 C C   . SER D 2 56  ? -15.345 -11.176 -9.946  1.00 14.21 ?  56   SER D C   1 
ATOM   6144 O O   . SER D 2 56  ? -15.967 -11.669 -9.003  1.00 15.92 ?  56   SER D O   1 
ATOM   6145 C CB  . SER D 2 56  ? -14.349 -9.010  -9.210  1.00 19.48 ?  56   SER D CB  1 
ATOM   6146 O OG  . SER D 2 56  ? -13.080 -9.599  -9.420  1.00 31.79 ?  56   SER D OG  1 
ATOM   6147 N N   . THR D 2 57  ? -14.621 -11.887 -10.802 1.00 14.67 ?  57   THR D N   1 
ATOM   6148 C CA  . THR D 2 57  ? -14.687 -13.353 -10.843 1.00 13.78 ?  57   THR D CA  1 
ATOM   6149 C C   . THR D 2 57  ? -13.316 -13.997 -10.614 1.00 15.72 ?  57   THR D C   1 
ATOM   6150 O O   . THR D 2 57  ? -12.256 -13.402 -10.879 1.00 13.76 ?  57   THR D O   1 
ATOM   6151 C CB  . THR D 2 57  ? -15.247 -13.824 -12.190 1.00 11.44 ?  57   THR D CB  1 
ATOM   6152 O OG1 . THR D 2 57  ? -14.355 -13.393 -13.256 1.00 14.47 ?  57   THR D OG1 1 
ATOM   6153 C CG2 . THR D 2 57  ? -16.700 -13.306 -12.410 1.00 14.69 ?  57   THR D CG2 1 
ATOM   6154 N N   . ILE D 2 58  ? -13.339 -15.251 -10.132 1.00 13.15 ?  58   ILE D N   1 
ATOM   6155 C CA  . ILE D 2 58  ? -12.142 -16.056 -9.908  1.00 12.74 ?  58   ILE D CA  1 
ATOM   6156 C C   . ILE D 2 58  ? -12.547 -17.515 -10.059 1.00 10.60 ?  58   ILE D C   1 
ATOM   6157 O O   . ILE D 2 58  ? -13.703 -17.882 -9.785  1.00 10.36 ?  58   ILE D O   1 
ATOM   6158 C CB  . ILE D 2 58  ? -11.496 -15.775 -8.527  1.00 12.74 ?  58   ILE D CB  1 
ATOM   6159 C CG1 . ILE D 2 58  ? -10.165 -16.515 -8.380  1.00 15.95 ?  58   ILE D CG1 1 
ATOM   6160 C CG2 . ILE D 2 58  ? -12.452 -16.120 -7.404  1.00 13.73 ?  58   ILE D CG2 1 
ATOM   6161 C CD1 . ILE D 2 58  ? -9.309  -15.956 -7.161  1.00 19.63 ?  58   ILE D CD1 1 
ATOM   6162 N N   . TYR D 2 59  ? -11.617 -18.326 -10.525 1.00 11.35 ?  59   TYR D N   1 
ATOM   6163 C CA  . TYR D 2 59  ? -11.879 -19.693 -10.963 1.00 10.64 ?  59   TYR D CA  1 
ATOM   6164 C C   . TYR D 2 59  ? -10.853 -20.667 -10.408 1.00 12.20 ?  59   TYR D C   1 
ATOM   6165 O O   . TYR D 2 59  ? -9.664  -20.356 -10.271 1.00 14.03 ?  59   TYR D O   1 
ATOM   6166 C CB  . TYR D 2 59  ? -11.882 -19.841 -12.500 1.00 10.57 ?  59   TYR D CB  1 
ATOM   6167 C CG  . TYR D 2 59  ? -12.942 -18.955 -13.137 1.00 10.16 ?  59   TYR D CG  1 
ATOM   6168 C CD1 . TYR D 2 59  ? -14.238 -19.430 -13.273 1.00 12.16 ?  59   TYR D CD1 1 
ATOM   6169 C CD2 . TYR D 2 59  ? -12.679 -17.644 -13.515 1.00 12.11 ?  59   TYR D CD2 1 
ATOM   6170 C CE1 . TYR D 2 59  ? -15.251 -18.624 -13.789 1.00 12.01 ?  59   TYR D CE1 1 
ATOM   6171 C CE2 . TYR D 2 59  ? -13.685 -16.836 -14.060 1.00 11.07 ?  59   TYR D CE2 1 
ATOM   6172 C CZ  . TYR D 2 59  ? -14.964 -17.351 -14.192 1.00 10.79 ?  59   TYR D CZ  1 
ATOM   6173 O OH  . TYR D 2 59  ? -15.943 -16.521 -14.723 1.00 11.90 ?  59   TYR D OH  1 
ATOM   6174 N N   . ALA D 2 60  ? -11.318 -21.891 -10.134 1.00 10.25 ?  60   ALA D N   1 
ATOM   6175 C CA  . ALA D 2 60  ? -10.405 -23.006 -9.863  1.00 8.90  ?  60   ALA D CA  1 
ATOM   6176 C C   . ALA D 2 60  ? -9.512  -23.274 -11.069 1.00 12.06 ?  60   ALA D C   1 
ATOM   6177 O O   . ALA D 2 60  ? -9.949  -23.212 -12.224 1.00 9.12  ?  60   ALA D O   1 
ATOM   6178 C CB  . ALA D 2 60  ? -11.238 -24.250 -9.516  1.00 11.38 ?  60   ALA D CB  1 
ATOM   6179 N N   . ASP D 2 61  ? -8.251  -23.632 -10.809 1.00 10.52 ?  61   ASP D N   1 
ATOM   6180 C CA  . ASP D 2 61  ? -7.352  -23.827 -11.935 1.00 10.32 ?  61   ASP D CA  1 
ATOM   6181 C C   . ASP D 2 61  ? -7.894  -24.853 -12.937 1.00 11.46 ?  61   ASP D C   1 
ATOM   6182 O O   . ASP D 2 61  ? -7.744  -24.671 -14.148 1.00 13.24 ?  61   ASP D O   1 
ATOM   6183 C CB  . ASP D 2 61  ? -5.943  -24.195 -11.438 1.00 9.38  ?  61   ASP D CB  1 
ATOM   6184 C CG  . ASP D 2 61  ? -5.882  -25.433 -10.563 1.00 14.16 ?  61   ASP D CG  1 
ATOM   6185 O OD1 . ASP D 2 61  ? -6.892  -26.104 -10.249 1.00 13.27 ?  61   ASP D OD1 1 
ATOM   6186 O OD2 . ASP D 2 61  ? -4.735  -25.736 -10.132 1.00 11.73 -1 61   ASP D OD2 1 
ATOM   6187 N N   . PHE D 2 62  ? -8.577  -25.899 -12.477 1.00 9.80  ?  62   PHE D N   1 
ATOM   6188 C CA  . PHE D 2 62  ? -9.015  -26.963 -13.384 1.00 11.18 ?  62   PHE D CA  1 
ATOM   6189 C C   . PHE D 2 62  ? -10.251 -26.602 -14.219 1.00 10.20 ?  62   PHE D C   1 
ATOM   6190 O O   . PHE D 2 62  ? -10.612 -27.392 -15.093 1.00 10.98 ?  62   PHE D O   1 
ATOM   6191 C CB  . PHE D 2 62  ? -9.278  -28.283 -12.620 1.00 12.48 ?  62   PHE D CB  1 
ATOM   6192 C CG  . PHE D 2 62  ? -10.200 -28.142 -11.425 1.00 10.91 ?  62   PHE D CG  1 
ATOM   6193 C CD1 . PHE D 2 62  ? -11.559 -28.256 -11.555 1.00 11.34 ?  62   PHE D CD1 1 
ATOM   6194 C CD2 . PHE D 2 62  ? -9.657  -27.897 -10.147 1.00 12.11 ?  62   PHE D CD2 1 
ATOM   6195 C CE1 . PHE D 2 62  ? -12.401 -28.093 -10.423 1.00 11.67 ?  62   PHE D CE1 1 
ATOM   6196 C CE2 . PHE D 2 62  ? -10.497 -27.750 -9.010  1.00 14.04 ?  62   PHE D CE2 1 
ATOM   6197 C CZ  . PHE D 2 62  ? -11.863 -27.858 -9.166  1.00 12.91 ?  62   PHE D CZ  1 
ATOM   6198 N N   . VAL D 2 63  ? -10.838 -25.412 -14.058 1.00 9.34  ?  63   VAL D N   1 
ATOM   6199 C CA  . VAL D 2 63  ? -11.866 -24.946 -14.985 1.00 10.15 ?  63   VAL D CA  1 
ATOM   6200 C C   . VAL D 2 63  ? -11.490 -23.670 -15.702 1.00 12.94 ?  63   VAL D C   1 
ATOM   6201 O O   . VAL D 2 63  ? -12.301 -23.157 -16.501 1.00 12.56 ?  63   VAL D O   1 
ATOM   6202 C CB  . VAL D 2 63  ? -13.253 -24.775 -14.299 1.00 10.83 ?  63   VAL D CB  1 
ATOM   6203 C CG1 . VAL D 2 63  ? -13.638 -26.079 -13.582 1.00 10.74 ?  63   VAL D CG1 1 
ATOM   6204 C CG2 . VAL D 2 63  ? -13.305 -23.588 -13.407 1.00 10.33 ?  63   VAL D CG2 1 
ATOM   6205 N N   . LYS D 2 64  ? -10.325 -23.101 -15.420 1.00 11.58 ?  64   LYS D N   1 
ATOM   6206 C CA  . LYS D 2 64  ? -9.999  -21.809 -16.006 1.00 13.78 ?  64   LYS D CA  1 
ATOM   6207 C C   . LYS D 2 64  ? -10.038 -21.875 -17.533 1.00 14.25 ?  64   LYS D C   1 
ATOM   6208 O O   . LYS D 2 64  ? -9.492  -22.806 -18.141 1.00 16.27 ?  64   LYS D O   1 
ATOM   6209 C CB  . LYS D 2 64  ? -8.600  -21.404 -15.527 1.00 17.49 ?  64   LYS D CB  1 
ATOM   6210 C CG  . LYS D 2 64  ? -8.316  -19.924 -15.566 1.00 22.49 ?  64   LYS D CG  1 
ATOM   6211 C CD  . LYS D 2 64  ? -7.061  -19.614 -14.757 1.00 26.58 ?  64   LYS D CD  1 
ATOM   6212 C CE  . LYS D 2 64  ? -6.477  -18.257 -15.157 1.00 35.15 ?  64   LYS D CE  1 
ATOM   6213 N NZ  . LYS D 2 64  ? -5.220  -17.954 -14.364 1.00 43.71 ?  64   LYS D NZ  1 
ATOM   6214 N N   . GLY D 2 65  ? -10.670 -20.870 -18.162 1.00 12.90 ?  65   GLY D N   1 
ATOM   6215 C CA  . GLY D 2 65  ? -10.807 -20.860 -19.618 1.00 14.72 ?  65   GLY D CA  1 
ATOM   6216 C C   . GLY D 2 65  ? -12.014 -21.615 -20.163 1.00 17.66 ?  65   GLY D C   1 
ATOM   6217 O O   . GLY D 2 65  ? -12.353 -21.462 -21.356 1.00 19.83 ?  65   GLY D O   1 
ATOM   6218 N N   . ARG D 2 66  ? -12.679 -22.430 -19.343 1.00 12.95 ?  66   ARG D N   1 
ATOM   6219 C CA  . ARG D 2 66  ? -13.829 -23.217 -19.797 1.00 12.49 ?  66   ARG D CA  1 
ATOM   6220 C C   . ARG D 2 66  ? -15.135 -22.800 -19.162 1.00 14.08 ?  66   ARG D C   1 
ATOM   6221 O O   . ARG D 2 66  ? -16.196 -22.952 -19.789 1.00 13.90 ?  66   ARG D O   1 
ATOM   6222 C CB  . ARG D 2 66  ? -13.626 -24.706 -19.461 1.00 13.62 ?  66   ARG D CB  1 
ATOM   6223 C CG  . ARG D 2 66  ? -12.431 -25.355 -20.179 1.00 13.59 ?  66   ARG D CG  1 
ATOM   6224 C CD  . ARG D 2 66  ? -12.391 -26.864 -19.988 1.00 13.61 ?  66   ARG D CD  1 
ATOM   6225 N NE  . ARG D 2 66  ? -12.283 -27.238 -18.566 1.00 12.50 ?  66   ARG D NE  1 
ATOM   6226 C CZ  . ARG D 2 66  ? -13.091 -28.120 -17.991 1.00 13.61 ?  66   ARG D CZ  1 
ATOM   6227 N NH1 . ARG D 2 66  ? -14.070 -28.701 -18.674 1.00 11.39 ?  66   ARG D NH1 1 
ATOM   6228 N NH2 . ARG D 2 66  ? -12.932 -28.403 -16.696 1.00 10.43 ?  66   ARG D NH2 1 
ATOM   6229 N N   . PHE D 2 67  ? -15.095 -22.384 -17.899 1.00 13.04 ?  67   PHE D N   1 
ATOM   6230 C CA  . PHE D 2 67  ? -16.285 -22.005 -17.155 1.00 11.08 ?  67   PHE D CA  1 
ATOM   6231 C C   . PHE D 2 67  ? -16.313 -20.495 -16.963 1.00 13.16 ?  67   PHE D C   1 
ATOM   6232 O O   . PHE D 2 67  ? -15.262 -19.855 -16.795 1.00 11.43 ?  67   PHE D O   1 
ATOM   6233 C CB  . PHE D 2 67  ? -16.311 -22.667 -15.747 1.00 11.39 ?  67   PHE D CB  1 
ATOM   6234 C CG  . PHE D 2 67  ? -16.541 -24.191 -15.726 1.00 10.05 ?  67   PHE D CG  1 
ATOM   6235 C CD1 . PHE D 2 67  ? -16.427 -25.002 -16.856 1.00 11.25 ?  67   PHE D CD1 1 
ATOM   6236 C CD2 . PHE D 2 67  ? -16.851 -24.795 -14.514 1.00 12.06 ?  67   PHE D CD2 1 
ATOM   6237 C CE1 . PHE D 2 67  ? -16.604 -26.414 -16.771 1.00 12.84 ?  67   PHE D CE1 1 
ATOM   6238 C CE2 . PHE D 2 67  ? -17.045 -26.213 -14.423 1.00 10.07 ?  67   PHE D CE2 1 
ATOM   6239 C CZ  . PHE D 2 67  ? -16.922 -27.002 -15.513 1.00 12.64 ?  67   PHE D CZ  1 
ATOM   6240 N N   . THR D 2 68  ? -17.535 -19.927 -16.935 1.00 11.71 ?  68   THR D N   1 
ATOM   6241 C CA  . THR D 2 68  ? -17.776 -18.509 -16.674 1.00 10.81 ?  68   THR D CA  1 
ATOM   6242 C C   . THR D 2 68  ? -18.899 -18.404 -15.653 1.00 10.74 ?  68   THR D C   1 
ATOM   6243 O O   . THR D 2 68  ? -20.005 -18.886 -15.913 1.00 12.20 ?  68   THR D O   1 
ATOM   6244 C CB  . THR D 2 68  ? -18.179 -17.742 -17.947 1.00 13.22 ?  68   THR D CB  1 
ATOM   6245 O OG1 . THR D 2 68  ? -17.182 -17.955 -18.958 1.00 13.20 ?  68   THR D OG1 1 
ATOM   6246 C CG2 . THR D 2 68  ? -18.259 -16.259 -17.639 1.00 12.47 ?  68   THR D CG2 1 
ATOM   6247 N N   . ILE D 2 69  ? -18.655 -17.735 -14.531 1.00 9.87  ?  69   ILE D N   1 
ATOM   6248 C CA  . ILE D 2 69  ? -19.702 -17.414 -13.558 1.00 9.27  ?  69   ILE D CA  1 
ATOM   6249 C C   . ILE D 2 69  ? -20.185 -15.989 -13.818 1.00 11.55 ?  69   ILE D C   1 
ATOM   6250 O O   . ILE D 2 69  ? -19.386 -15.097 -14.192 1.00 12.27 ?  69   ILE D O   1 
ATOM   6251 C CB  . ILE D 2 69  ? -19.183 -17.588 -12.108 1.00 9.25  ?  69   ILE D CB  1 
ATOM   6252 C CG1 . ILE D 2 69  ? -20.297 -17.369 -11.065 1.00 9.35  ?  69   ILE D CG1 1 
ATOM   6253 C CG2 . ILE D 2 69  ? -17.906 -16.662 -11.822 1.00 11.63 ?  69   ILE D CG2 1 
ATOM   6254 C CD1 . ILE D 2 69  ? -19.803 -17.782 -9.616  1.00 9.73  ?  69   ILE D CD1 1 
ATOM   6255 N N   . SER D 2 70  ? -21.497 -15.789 -13.685 1.00 10.18 ?  70   SER D N   1 
ATOM   6256 C CA  . SER D 2 70  ? -22.078 -14.456 -13.834 1.00 10.68 ?  70   SER D CA  1 
ATOM   6257 C C   . SER D 2 70  ? -23.298 -14.339 -12.928 1.00 11.64 ?  70   SER D C   1 
ATOM   6258 O O   . SER D 2 70  ? -23.748 -15.319 -12.344 1.00 10.64 ?  70   SER D O   1 
ATOM   6259 C CB  . SER D 2 70  ? -22.464 -14.201 -15.301 1.00 13.21 ?  70   SER D CB  1 
ATOM   6260 O OG  . SER D 2 70  ? -23.426 -15.177 -15.722 1.00 13.48 ?  70   SER D OG  1 
ATOM   6261 N N   . ARG D 2 71  ? -23.863 -13.111 -12.825 1.00 10.55 ?  71   ARG D N   1 
ATOM   6262 C CA  . ARG D 2 71  ? -24.986 -12.878 -11.934 1.00 11.06 ?  71   ARG D CA  1 
ATOM   6263 C C   . ARG D 2 71  ? -25.939 -11.883 -12.575 1.00 13.17 ?  71   ARG D C   1 
ATOM   6264 O O   . ARG D 2 71  ? -25.510 -10.999 -13.331 1.00 14.81 ?  71   ARG D O   1 
ATOM   6265 C CB  . ARG D 2 71  ? -24.513 -12.347 -10.560 1.00 12.90 ?  71   ARG D CB  1 
ATOM   6266 C CG  . ARG D 2 71  ? -23.804 -10.991 -10.647 1.00 13.91 ?  71   ARG D CG  1 
ATOM   6267 C CD  . ARG D 2 71  ? -23.109 -10.609 -9.309  1.00 14.33 ?  71   ARG D CD  1 
ATOM   6268 N NE  . ARG D 2 71  ? -24.067 -10.397 -8.229  1.00 13.31 ?  71   ARG D NE  1 
ATOM   6269 C CZ  . ARG D 2 71  ? -23.835 -10.642 -6.947  1.00 14.51 ?  71   ARG D CZ  1 
ATOM   6270 N NH1 . ARG D 2 71  ? -22.647 -11.089 -6.526  1.00 12.72 ?  71   ARG D NH1 1 
ATOM   6271 N NH2 . ARG D 2 71  ? -24.815 -10.454 -6.058  1.00 14.06 ?  71   ARG D NH2 1 
ATOM   6272 N N   . ASP D 2 72  ? -27.225 -12.068 -12.290 1.00 12.76 ?  72   ASP D N   1 
ATOM   6273 C CA  . ASP D 2 72  ? -28.287 -11.126 -12.678 1.00 16.17 ?  72   ASP D CA  1 
ATOM   6274 C C   . ASP D 2 72  ? -29.007 -10.707 -11.407 1.00 13.56 ?  72   ASP D C   1 
ATOM   6275 O O   . ASP D 2 72  ? -29.812 -11.469 -10.863 1.00 15.23 ?  72   ASP D O   1 
ATOM   6276 C CB  . ASP D 2 72  ? -29.221 -11.797 -13.678 1.00 17.80 ?  72   ASP D CB  1 
ATOM   6277 C CG  . ASP D 2 72  ? -30.338 -10.869 -14.165 1.00 23.08 ?  72   ASP D CG  1 
ATOM   6278 O OD1 . ASP D 2 72  ? -30.699 -9.936  -13.429 1.00 22.65 ?  72   ASP D OD1 1 
ATOM   6279 O OD2 . ASP D 2 72  ? -30.850 -11.113 -15.281 1.00 25.61 -1 72   ASP D OD2 1 
ATOM   6280 N N   . ASN D 2 73  ? -28.704 -9.507  -10.903 1.00 15.02 ?  73   ASN D N   1 
ATOM   6281 C CA  . ASN D 2 73  ? -29.265 -9.075  -9.628  1.00 15.69 ?  73   ASN D CA  1 
ATOM   6282 C C   . ASN D 2 73  ? -30.787 -8.922  -9.682  1.00 17.99 ?  73   ASN D C   1 
ATOM   6283 O O   . ASN D 2 73  ? -31.470 -9.216  -8.697  1.00 18.32 ?  73   ASN D O   1 
ATOM   6284 C CB  . ASN D 2 73  ? -28.602 -7.774  -9.191  1.00 16.44 ?  73   ASN D CB  1 
ATOM   6285 C CG  . ASN D 2 73  ? -27.183 -7.971  -8.663  1.00 20.40 ?  73   ASN D CG  1 
ATOM   6286 O OD1 . ASN D 2 73  ? -26.712 -9.089  -8.471  1.00 16.90 ?  73   ASN D OD1 1 
ATOM   6287 N ND2 . ASN D 2 73  ? -26.506 -6.861  -8.399  1.00 22.26 ?  73   ASN D ND2 1 
ATOM   6288 N N   . ALA D 2 74  ? -31.339 -8.499  -10.823 1.00 17.46 ?  74   ALA D N   1 
ATOM   6289 C CA  . ALA D 2 74  ? -32.786 -8.319  -10.867 1.00 19.29 ?  74   ALA D CA  1 
ATOM   6290 C C   . ALA D 2 74  ? -33.513 -9.649  -10.732 1.00 19.07 ?  74   ALA D C   1 
ATOM   6291 O O   . ALA D 2 74  ? -34.639 -9.692  -10.213 1.00 21.54 ?  74   ALA D O   1 
ATOM   6292 C CB  . ALA D 2 74  ? -33.210 -7.626  -12.174 1.00 19.71 ?  74   ALA D CB  1 
ATOM   6293 N N   . LYS D 2 75  ? -32.882 -10.727 -11.170 1.00 15.22 ?  75   LYS D N   1 
ATOM   6294 C CA  . LYS D 2 75  ? -33.441 -12.070 -11.119 1.00 16.57 ?  75   LYS D CA  1 
ATOM   6295 C C   . LYS D 2 75  ? -32.955 -12.852 -9.905  1.00 17.20 ?  75   LYS D C   1 
ATOM   6296 O O   . LYS D 2 75  ? -33.359 -14.013 -9.747  1.00 14.67 ?  75   LYS D O   1 
ATOM   6297 C CB  . LYS D 2 75  ? -33.060 -12.864 -12.386 1.00 20.09 ?  75   LYS D CB  1 
ATOM   6298 C CG  . LYS D 2 75  ? -33.613 -12.365 -13.737 1.00 25.88 ?  75   LYS D CG  1 
ATOM   6299 C CD  . LYS D 2 75  ? -33.162 -13.336 -14.859 1.00 34.44 ?  75   LYS D CD  1 
ATOM   6300 C CE  . LYS D 2 75  ? -32.812 -12.658 -16.203 1.00 37.19 ?  75   LYS D CE  1 
ATOM   6301 N NZ  . LYS D 2 75  ? -33.823 -12.875 -17.291 1.00 39.25 ?  75   LYS D NZ  1 
ATOM   6302 N N   . ASN D 2 76  ? -32.079 -12.256 -9.070  1.00 12.48 ?  76   ASN D N   1 
ATOM   6303 C CA  A ASN D 2 76  ? -31.481 -12.988 -7.957  0.50 15.10 ?  76   ASN D CA  1 
ATOM   6304 C CA  B ASN D 2 76  ? -31.393 -12.950 -7.970  0.50 15.10 ?  76   ASN D CA  1 
ATOM   6305 C C   . ASN D 2 76  ? -30.969 -14.357 -8.401  1.00 14.85 ?  76   ASN D C   1 
ATOM   6306 O O   . ASN D 2 76  ? -31.185 -15.361 -7.726  1.00 12.87 ?  76   ASN D O   1 
ATOM   6307 C CB  A ASN D 2 76  ? -32.483 -13.129 -6.816  0.50 15.22 ?  76   ASN D CB  1 
ATOM   6308 C CB  B ASN D 2 76  ? -32.206 -12.889 -6.656  0.50 15.22 ?  76   ASN D CB  1 
ATOM   6309 C CG  A ASN D 2 76  ? -32.730 -11.820 -6.098  0.50 15.51 ?  76   ASN D CG  1 
ATOM   6310 C CG  B ASN D 2 76  ? -33.538 -13.630 -6.676  0.50 15.51 ?  76   ASN D CG  1 
ATOM   6311 O OD1 A ASN D 2 76  ? -32.609 -10.755 -6.680  0.50 18.64 ?  76   ASN D OD1 1 
ATOM   6312 O OD1 B ASN D 2 76  ? -33.641 -14.839 -6.427  0.50 18.64 ?  76   ASN D OD1 1 
ATOM   6313 N ND2 A ASN D 2 76  ? -33.058 -11.904 -4.822  0.50 19.41 ?  76   ASN D ND2 1 
ATOM   6314 N ND2 B ASN D 2 76  ? -34.602 -12.855 -6.907  0.50 19.41 ?  76   ASN D ND2 1 
ATOM   6315 N N   . THR D 2 77  ? -30.280 -14.382 -9.531  1.00 13.10 ?  77   THR D N   1 
ATOM   6316 C CA  . THR D 2 77  ? -29.811 -15.632 -10.123 1.00 11.85 ?  77   THR D CA  1 
ATOM   6317 C C   . THR D 2 77  ? -28.316 -15.554 -10.411 1.00 13.19 ?  77   THR D C   1 
ATOM   6318 O O   . THR D 2 77  ? -27.816 -14.531 -10.909 1.00 11.23 ?  77   THR D O   1 
ATOM   6319 C CB  . THR D 2 77  ? -30.594 -15.945 -11.406 1.00 15.33 ?  77   THR D CB  1 
ATOM   6320 O OG1 . THR D 2 77  ? -31.966 -16.126 -11.035 1.00 16.03 ?  77   THR D OG1 1 
ATOM   6321 C CG2 . THR D 2 77  ? -30.061 -17.229 -12.081 1.00 14.71 ?  77   THR D CG2 1 
ATOM   6322 N N   . VAL D 2 78  ? -27.594 -16.641 -10.082 1.00 10.92 ?  78   VAL D N   1 
ATOM   6323 C CA  . VAL D 2 78  ? -26.203 -16.832 -10.485 1.00 11.57 ?  78   VAL D CA  1 
ATOM   6324 C C   . VAL D 2 78  ? -26.162 -17.890 -11.575 1.00 9.44  ?  78   VAL D C   1 
ATOM   6325 O O   . VAL D 2 78  ? -26.884 -18.898 -11.497 1.00 10.74 ?  78   VAL D O   1 
ATOM   6326 C CB  . VAL D 2 78  ? -25.328 -17.314 -9.301  1.00 10.69 ?  78   VAL D CB  1 
ATOM   6327 C CG1 . VAL D 2 78  ? -23.835 -17.236 -9.695  1.00 12.75 ?  78   VAL D CG1 1 
ATOM   6328 C CG2 . VAL D 2 78  ? -25.627 -16.448 -8.061  1.00 16.26 ?  78   VAL D CG2 1 
ATOM   6329 N N   . PHE D 2 79  ? -25.309 -17.702 -12.572 1.00 8.87  ?  79   PHE D N   1 
ATOM   6330 C CA  . PHE D 2 79  ? -25.180 -18.685 -13.647 1.00 9.23  ?  79   PHE D CA  1 
ATOM   6331 C C   . PHE D 2 79  ? -23.771 -19.254 -13.694 1.00 9.41  ?  79   PHE D C   1 
ATOM   6332 O O   . PHE D 2 79  ? -22.791 -18.570 -13.328 1.00 8.85  ?  79   PHE D O   1 
ATOM   6333 C CB  . PHE D 2 79  ? -25.472 -18.038 -15.037 1.00 12.52 ?  79   PHE D CB  1 
ATOM   6334 C CG  . PHE D 2 79  ? -26.836 -17.380 -15.114 1.00 13.50 ?  79   PHE D CG  1 
ATOM   6335 C CD1 . PHE D 2 79  ? -27.962 -18.139 -15.431 1.00 17.07 ?  79   PHE D CD1 1 
ATOM   6336 C CD2 . PHE D 2 79  ? -26.986 -16.048 -14.835 1.00 15.96 ?  79   PHE D CD2 1 
ATOM   6337 C CE1 . PHE D 2 79  ? -29.239 -17.536 -15.496 1.00 17.51 ?  79   PHE D CE1 1 
ATOM   6338 C CE2 . PHE D 2 79  ? -28.252 -15.449 -14.892 1.00 19.25 ?  79   PHE D CE2 1 
ATOM   6339 C CZ  . PHE D 2 79  ? -29.356 -16.188 -15.234 1.00 20.03 ?  79   PHE D CZ  1 
ATOM   6340 N N   . LEU D 2 80  ? -23.658 -20.467 -14.232 1.00 8.93  ?  80   LEU D N   1 
ATOM   6341 C CA  . LEU D 2 80  ? -22.361 -21.076 -14.543 1.00 9.67  ?  80   LEU D CA  1 
ATOM   6342 C C   . LEU D 2 80  ? -22.392 -21.613 -15.976 1.00 9.49  ?  80   LEU D C   1 
ATOM   6343 O O   . LEU D 2 80  ? -23.068 -22.611 -16.252 1.00 8.96  ?  80   LEU D O   1 
ATOM   6344 C CB  . LEU D 2 80  ? -22.033 -22.212 -13.567 1.00 9.74  ?  80   LEU D CB  1 
ATOM   6345 C CG  . LEU D 2 80  ? -20.574 -22.725 -13.668 1.00 9.52  ?  80   LEU D CG  1 
ATOM   6346 C CD1 . LEU D 2 80  ? -19.536 -21.630 -13.269 1.00 10.75 ?  80   LEU D CD1 1 
ATOM   6347 C CD2 . LEU D 2 80  ? -20.451 -23.967 -12.783 1.00 8.60  ?  80   LEU D CD2 1 
ATOM   6348 N N   . GLN D 2 81  ? -21.664 -20.969 -16.889 1.00 9.67  ?  81   GLN D N   1 
ATOM   6349 C CA  . GLN D 2 81  ? -21.563 -21.432 -18.274 1.00 10.15 ?  81   GLN D CA  1 
ATOM   6350 C C   . GLN D 2 81  ? -20.396 -22.408 -18.360 1.00 10.58 ?  81   GLN D C   1 
ATOM   6351 O O   . GLN D 2 81  ? -19.280 -22.052 -17.956 1.00 12.47 ?  81   GLN D O   1 
ATOM   6352 C CB  . GLN D 2 81  ? -21.346 -20.239 -19.206 1.00 14.16 ?  81   GLN D CB  1 
ATOM   6353 C CG  . GLN D 2 81  ? -21.140 -20.673 -20.674 1.00 14.91 ?  81   GLN D CG  1 
ATOM   6354 C CD  . GLN D 2 81  ? -22.384 -21.345 -21.274 1.00 15.38 ?  81   GLN D CD  1 
ATOM   6355 O OE1 . GLN D 2 81  ? -23.510 -20.848 -21.106 1.00 19.18 ?  81   GLN D OE1 1 
ATOM   6356 N NE2 . GLN D 2 81  ? -22.185 -22.429 -22.013 1.00 17.41 ?  81   GLN D NE2 1 
ATOM   6357 N N   . MET D 2 82  ? -20.658 -23.640 -18.797 1.00 9.68  ?  82   MET D N   1 
ATOM   6358 C CA  . MET D 2 82  ? -19.639 -24.709 -18.784 1.00 11.41 ?  82   MET D CA  1 
ATOM   6359 C C   . MET D 2 82  ? -19.359 -25.172 -20.207 1.00 12.04 ?  82   MET D C   1 
ATOM   6360 O O   . MET D 2 82  ? -20.215 -25.798 -20.836 1.00 12.94 ?  82   MET D O   1 
ATOM   6361 C CB  . MET D 2 82  ? -20.117 -25.860 -17.886 1.00 12.79 ?  82   MET D CB  1 
ATOM   6362 C CG  . MET D 2 82  ? -20.530 -25.335 -16.487 1.00 12.73 ?  82   MET D CG  1 
ATOM   6363 S SD  . MET D 2 82  ? -21.344 -26.617 -15.456 1.00 20.59 ?  82   MET D SD  1 
ATOM   6364 C CE  . MET D 2 82  ? -20.282 -27.891 -15.590 1.00 15.26 ?  82   MET D CE  1 
ATOM   6365 N N   . ASN D 2 83  ? -18.154 -24.865 -20.713 1.00 13.29 ?  83   ASN D N   1 
ATOM   6366 C CA  . ASN D 2 83  ? -17.765 -25.261 -22.062 1.00 14.21 ?  83   ASN D CA  1 
ATOM   6367 C C   . ASN D 2 83  ? -16.695 -26.354 -22.040 1.00 15.06 ?  83   ASN D C   1 
ATOM   6368 O O   . ASN D 2 83  ? -16.057 -26.618 -21.019 1.00 12.68 ?  83   ASN D O   1 
ATOM   6369 C CB  . ASN D 2 83  ? -17.224 -24.065 -22.848 1.00 16.18 ?  83   ASN D CB  1 
ATOM   6370 C CG  . ASN D 2 83  ? -18.236 -22.965 -23.019 1.00 18.99 ?  83   ASN D CG  1 
ATOM   6371 O OD1 . ASN D 2 83  ? -19.419 -23.213 -23.122 1.00 17.71 ?  83   ASN D OD1 1 
ATOM   6372 N ND2 . ASN D 2 83  ? -17.765 -21.735 -23.036 1.00 20.72 ?  83   ASN D ND2 1 
ATOM   6373 N N   . SER D 2 84  ? -16.516 -27.010 -23.199 1.00 13.58 ?  84   SER D N   1 
ATOM   6374 C CA  . SER D 2 84  ? -15.461 -28.021 -23.379 1.00 13.64 ?  84   SER D CA  1 
ATOM   6375 C C   . SER D 2 84  ? -15.486 -29.047 -22.242 1.00 13.75 ?  84   SER D C   1 
ATOM   6376 O O   . SER D 2 84  ? -14.475 -29.354 -21.590 1.00 13.43 ?  84   SER D O   1 
ATOM   6377 C CB  . SER D 2 84  ? -14.084 -27.364 -23.502 1.00 15.91 ?  84   SER D CB  1 
ATOM   6378 O OG  . SER D 2 84  ? -14.055 -26.298 -24.478 1.00 19.19 ?  84   SER D OG  1 
ATOM   6379 N N   . LEU D 2 85  ? -16.677 -29.589 -22.005 1.00 10.78 ?  85   LEU D N   1 
ATOM   6380 C CA  . LEU D 2 85  ? -16.851 -30.480 -20.875 1.00 9.67  ?  85   LEU D CA  1 
ATOM   6381 C C   . LEU D 2 85  ? -16.126 -31.819 -21.048 1.00 14.40 ?  85   LEU D C   1 
ATOM   6382 O O   . LEU D 2 85  ? -15.966 -32.344 -22.158 1.00 14.88 ?  85   LEU D O   1 
ATOM   6383 C CB  . LEU D 2 85  ? -18.350 -30.699 -20.644 1.00 11.82 ?  85   LEU D CB  1 
ATOM   6384 C CG  . LEU D 2 85  ? -18.951 -29.472 -19.976 1.00 12.75 ?  85   LEU D CG  1 
ATOM   6385 C CD1 . LEU D 2 85  ? -20.526 -29.482 -20.094 1.00 13.89 ?  85   LEU D CD1 1 
ATOM   6386 C CD2 . LEU D 2 85  ? -18.587 -29.477 -18.468 1.00 14.27 ?  85   LEU D CD2 1 
ATOM   6387 N N   . LYS D 2 86  ? -15.691 -32.382 -19.925 1.00 11.39 ?  86   LYS D N   1 
ATOM   6388 C CA  . LYS D 2 86  ? -14.988 -33.655 -19.882 1.00 15.20 ?  86   LYS D CA  1 
ATOM   6389 C C   . LYS D 2 86  ? -15.640 -34.591 -18.882 1.00 12.23 ?  86   LYS D C   1 
ATOM   6390 O O   . LYS D 2 86  ? -16.289 -34.133 -17.944 1.00 11.69 ?  86   LYS D O   1 
ATOM   6391 C CB  . LYS D 2 86  ? -13.521 -33.447 -19.470 1.00 17.27 ?  86   LYS D CB  1 
ATOM   6392 C CG  . LYS D 2 86  ? -12.724 -32.516 -20.354 1.00 21.62 ?  86   LYS D CG  1 
ATOM   6393 C CD  . LYS D 2 86  ? -11.237 -32.660 -19.930 1.00 27.60 ?  86   LYS D CD  1 
ATOM   6394 C CE  . LYS D 2 86  ? -11.039 -32.235 -18.480 1.00 26.92 ?  86   LYS D CE  1 
ATOM   6395 N NZ  . LYS D 2 86  ? -9.680  -31.591 -18.178 1.00 23.68 ?  86   LYS D NZ  1 
ATOM   6396 N N   . PRO D 2 87  ? -15.452 -35.898 -19.031 1.00 10.86 ?  87   PRO D N   1 
ATOM   6397 C CA  . PRO D 2 87  ? -16.000 -36.857 -18.051 1.00 12.34 ?  87   PRO D CA  1 
ATOM   6398 C C   . PRO D 2 87  ? -15.608 -36.539 -16.596 1.00 14.77 ?  87   PRO D C   1 
ATOM   6399 O O   . PRO D 2 87  ? -16.420 -36.757 -15.682 1.00 13.02 ?  87   PRO D O   1 
ATOM   6400 C CB  . PRO D 2 87  ? -15.439 -38.213 -18.550 1.00 15.98 ?  87   PRO D CB  1 
ATOM   6401 C CG  . PRO D 2 87  ? -15.282 -37.990 -20.042 1.00 17.20 ?  87   PRO D CG  1 
ATOM   6402 C CD  . PRO D 2 87  ? -14.787 -36.551 -20.176 1.00 14.54 ?  87   PRO D CD  1 
ATOM   6403 N N   . GLU D 2 88  ? -14.412 -35.980 -16.358 1.00 11.99 ?  88   GLU D N   1 
ATOM   6404 C CA  . GLU D 2 88  ? -13.988 -35.579 -15.028 1.00 13.32 ?  88   GLU D CA  1 
ATOM   6405 C C   . GLU D 2 88  ? -14.810 -34.432 -14.467 1.00 12.30 ?  88   GLU D C   1 
ATOM   6406 O O   . GLU D 2 88  ? -14.737 -34.172 -13.262 1.00 13.06 ?  88   GLU D O   1 
ATOM   6407 C CB  . GLU D 2 88  ? -12.477 -35.221 -15.004 1.00 16.61 ?  88   GLU D CB  1 
ATOM   6408 C CG  . GLU D 2 88  ? -11.471 -36.301 -15.485 1.00 24.67 ?  88   GLU D CG  1 
ATOM   6409 C CD  . GLU D 2 88  ? -11.640 -36.831 -16.920 1.00 30.84 ?  88   GLU D CD  1 
ATOM   6410 O OE1 . GLU D 2 88  ? -11.922 -36.057 -17.851 1.00 20.18 ?  88   GLU D OE1 1 
ATOM   6411 O OE2 . GLU D 2 88  ? -11.446 -38.072 -17.102 1.00 41.95 -1 88   GLU D OE2 1 
ATOM   6412 N N   . ASP D 2 89  ? -15.649 -33.795 -15.286 1.00 10.92 ?  89   ASP D N   1 
ATOM   6413 C CA  . ASP D 2 89  ? -16.532 -32.762 -14.767 1.00 10.56 ?  89   ASP D CA  1 
ATOM   6414 C C   . ASP D 2 89  ? -17.855 -33.351 -14.250 1.00 9.11  ?  89   ASP D C   1 
ATOM   6415 O O   . ASP D 2 89  ? -18.690 -32.591 -13.740 1.00 9.79  ?  89   ASP D O   1 
ATOM   6416 C CB  . ASP D 2 89  ? -16.850 -31.707 -15.848 1.00 9.21  ?  89   ASP D CB  1 
ATOM   6417 C CG  . ASP D 2 89  ? -15.614 -30.916 -16.306 1.00 12.87 ?  89   ASP D CG  1 
ATOM   6418 O OD1 . ASP D 2 89  ? -14.856 -30.455 -15.450 1.00 12.36 ?  89   ASP D OD1 1 
ATOM   6419 O OD2 . ASP D 2 89  ? -15.411 -30.799 -17.536 1.00 13.67 -1 89   ASP D OD2 1 
ATOM   6420 N N   . THR D 2 90  ? -18.082 -34.665 -14.358 1.00 8.45  ?  90   THR D N   1 
ATOM   6421 C CA  . THR D 2 90  ? -19.333 -35.250 -13.855 1.00 8.82  ?  90   THR D CA  1 
ATOM   6422 C C   . THR D 2 90  ? -19.443 -35.072 -12.347 1.00 9.51  ?  90   THR D C   1 
ATOM   6423 O O   . THR D 2 90  ? -18.499 -35.389 -11.604 1.00 9.92  ?  90   THR D O   1 
ATOM   6424 C CB  . THR D 2 90  ? -19.346 -36.737 -14.214 1.00 9.85  ?  90   THR D CB  1 
ATOM   6425 O OG1 . THR D 2 90  ? -19.429 -36.845 -15.643 1.00 9.83  ?  90   THR D OG1 1 
ATOM   6426 C CG2 . THR D 2 90  ? -20.537 -37.464 -13.545 1.00 10.21 ?  90   THR D CG2 1 
ATOM   6427 N N   . ALA D 2 91  ? -20.573 -34.515 -11.879 1.00 8.08  ?  91   ALA D N   1 
ATOM   6428 C CA  . ALA D 2 91  ? -20.740 -34.284 -10.438 1.00 8.61  ?  91   ALA D CA  1 
ATOM   6429 C C   . ALA D 2 91  ? -22.130 -33.697 -10.212 1.00 7.73  ?  91   ALA D C   1 
ATOM   6430 O O   . ALA D 2 91  ? -22.788 -33.283 -11.167 1.00 8.98  ?  91   ALA D O   1 
ATOM   6431 C CB  . ALA D 2 91  ? -19.708 -33.264 -9.898  1.00 8.87  ?  91   ALA D CB  1 
ATOM   6432 N N   . VAL D 2 92  ? -22.530 -33.586 -8.938  1.00 7.39  ?  92   VAL D N   1 
ATOM   6433 C CA  . VAL D 2 92  ? -23.646 -32.721 -8.571  1.00 8.13  ?  92   VAL D CA  1 
ATOM   6434 C C   . VAL D 2 92  ? -23.098 -31.323 -8.347  1.00 10.41 ?  92   VAL D C   1 
ATOM   6435 O O   . VAL D 2 92  ? -22.097 -31.155 -7.628  1.00 8.69  ?  92   VAL D O   1 
ATOM   6436 C CB  . VAL D 2 92  ? -24.354 -33.217 -7.311  1.00 9.38  ?  92   VAL D CB  1 
ATOM   6437 C CG1 . VAL D 2 92  ? -25.567 -32.299 -6.985  1.00 8.83  ?  92   VAL D CG1 1 
ATOM   6438 C CG2 . VAL D 2 92  ? -24.844 -34.651 -7.528  1.00 10.35 ?  92   VAL D CG2 1 
ATOM   6439 N N   . TYR D 2 93  ? -23.717 -30.325 -8.973  1.00 8.07  ?  93   TYR D N   1 
ATOM   6440 C CA  . TYR D 2 93  ? -23.272 -28.937 -8.882  1.00 7.12  ?  93   TYR D CA  1 
ATOM   6441 C C   . TYR D 2 93  ? -24.207 -28.156 -7.965  1.00 8.45  ?  93   TYR D C   1 
ATOM   6442 O O   . TYR D 2 93  ? -25.430 -28.340 -8.014  1.00 9.74  ?  93   TYR D O   1 
ATOM   6443 C CB  . TYR D 2 93  ? -23.204 -28.257 -10.275 1.00 6.66  ?  93   TYR D CB  1 
ATOM   6444 C CG  . TYR D 2 93  ? -22.003 -28.699 -11.063 1.00 7.46  ?  93   TYR D CG  1 
ATOM   6445 C CD1 . TYR D 2 93  ? -21.916 -30.012 -11.558 1.00 7.71  ?  93   TYR D CD1 1 
ATOM   6446 C CD2 . TYR D 2 93  ? -20.933 -27.804 -11.335 1.00 7.49  ?  93   TYR D CD2 1 
ATOM   6447 C CE1 . TYR D 2 93  ? -20.772 -30.430 -12.259 1.00 8.79  ?  93   TYR D CE1 1 
ATOM   6448 C CE2 . TYR D 2 93  ? -19.802 -28.214 -12.039 1.00 7.22  ?  93   TYR D CE2 1 
ATOM   6449 C CZ  . TYR D 2 93  ? -19.717 -29.511 -12.485 1.00 8.15  ?  93   TYR D CZ  1 
ATOM   6450 O OH  . TYR D 2 93  ? -18.600 -29.910 -13.196 1.00 8.94  ?  93   TYR D OH  1 
ATOM   6451 N N   . TYR D 2 94  ? -23.623 -27.261 -7.159  1.00 7.61  ?  94   TYR D N   1 
ATOM   6452 C CA  . TYR D 2 94  ? -24.331 -26.494 -6.133  1.00 6.87  ?  94   TYR D CA  1 
ATOM   6453 C C   . TYR D 2 94  ? -23.886 -25.047 -6.151  1.00 9.41  ?  94   TYR D C   1 
ATOM   6454 O O   . TYR D 2 94  ? -22.691 -24.758 -6.372  1.00 7.71  ?  94   TYR D O   1 
ATOM   6455 C CB  . TYR D 2 94  ? -24.001 -26.999 -4.717  1.00 7.22  ?  94   TYR D CB  1 
ATOM   6456 C CG  . TYR D 2 94  ? -24.342 -28.449 -4.436  1.00 5.79  ?  94   TYR D CG  1 
ATOM   6457 C CD1 . TYR D 2 94  ? -23.391 -29.458 -4.665  1.00 8.36  ?  94   TYR D CD1 1 
ATOM   6458 C CD2 . TYR D 2 94  ? -25.545 -28.785 -3.828  1.00 8.17  ?  94   TYR D CD2 1 
ATOM   6459 C CE1 . TYR D 2 94  ? -23.626 -30.782 -4.363  1.00 10.08 ?  94   TYR D CE1 1 
ATOM   6460 C CE2 . TYR D 2 94  ? -25.798 -30.132 -3.524  1.00 9.64  ?  94   TYR D CE2 1 
ATOM   6461 C CZ  . TYR D 2 94  ? -24.855 -31.095 -3.790  1.00 11.24 ?  94   TYR D CZ  1 
ATOM   6462 O OH  . TYR D 2 94  ? -25.133 -32.415 -3.502  1.00 12.82 ?  94   TYR D OH  1 
ATOM   6463 N N   . CYS D 2 95  ? -24.813 -24.135 -5.862  1.00 6.93  ?  95   CYS D N   1 
ATOM   6464 C CA  . CYS D 2 95  ? -24.347 -22.769 -5.585  1.00 8.49  ?  95   CYS D CA  1 
ATOM   6465 C C   . CYS D 2 95  ? -24.564 -22.407 -4.119  1.00 10.18 ?  95   CYS D C   1 
ATOM   6466 O O   . CYS D 2 95  ? -25.287 -23.086 -3.376  1.00 10.01 ?  95   CYS D O   1 
ATOM   6467 C CB  . CYS D 2 95  ? -24.964 -21.740 -6.538  1.00 11.92 ?  95   CYS D CB  1 
ATOM   6468 S SG  . CYS D 2 95  ? -26.348 -20.718 -5.917  1.00 24.77 ?  95   CYS D SG  1 
ATOM   6469 N N   . ASN D 2 96  ? -23.841 -21.378 -3.658  1.00 7.29  ?  96   ASN D N   1 
ATOM   6470 C CA  . ASN D 2 96  ? -24.067 -20.967 -2.274  1.00 7.41  ?  96   ASN D CA  1 
ATOM   6471 C C   . ASN D 2 96  ? -23.667 -19.504 -2.097  1.00 7.62  ?  96   ASN D C   1 
ATOM   6472 O O   . ASN D 2 96  ? -22.904 -18.969 -2.888  1.00 7.95  ?  96   ASN D O   1 
ATOM   6473 C CB  . ASN D 2 96  ? -23.259 -21.890 -1.294  1.00 8.59  ?  96   ASN D CB  1 
ATOM   6474 C CG  . ASN D 2 96  ? -23.964 -22.089 0.056   1.00 10.61 ?  96   ASN D CG  1 
ATOM   6475 O OD1 . ASN D 2 96  ? -24.394 -21.124 0.716   1.00 8.68  ?  96   ASN D OD1 1 
ATOM   6476 N ND2 . ASN D 2 96  ? -24.106 -23.360 0.477   1.00 8.22  ?  96   ASN D ND2 1 
ATOM   6477 N N   . ARG D 2 97  ? -24.183 -18.873 -1.027  1.00 7.84  ?  97   ARG D N   1 
ATOM   6478 C CA  . ARG D 2 97  ? -23.573 -17.623 -0.554  1.00 8.19  ?  97   ARG D CA  1 
ATOM   6479 C C   . ARG D 2 97  ? -22.152 -17.935 -0.103  1.00 8.61  ?  97   ARG D C   1 
ATOM   6480 O O   . ARG D 2 97  ? -21.917 -18.967 0.529   1.00 8.41  ?  97   ARG D O   1 
ATOM   6481 C CB  . ARG D 2 97  ? -24.356 -17.051 0.627   1.00 9.69  ?  97   ARG D CB  1 
ATOM   6482 C CG  . ARG D 2 97  ? -25.829 -16.715 0.300   1.00 10.03 ?  97   ARG D CG  1 
ATOM   6483 C CD  . ARG D 2 97  ? -26.528 -16.194 1.561   1.00 11.96 ?  97   ARG D CD  1 
ATOM   6484 N NE  . ARG D 2 97  ? -26.038 -14.867 1.941   1.00 11.57 ?  97   ARG D NE  1 
ATOM   6485 C CZ  . ARG D 2 97  ? -25.470 -14.537 3.111   1.00 14.39 ?  97   ARG D CZ  1 
ATOM   6486 N NH1 . ARG D 2 97  ? -25.388 -15.387 4.140   1.00 13.29 ?  97   ARG D NH1 1 
ATOM   6487 N NH2 . ARG D 2 97  ? -25.041 -13.291 3.296   1.00 14.20 ?  97   ARG D NH2 1 
ATOM   6488 N N   . ALA D 2 98  ? -21.216 -17.025 -0.376  1.00 8.15  ?  98   ALA D N   1 
ATOM   6489 C CA  . ALA D 2 98  ? -19.796 -17.310 -0.134  1.00 8.64  ?  98   ALA D CA  1 
ATOM   6490 C C   . ALA D 2 98  ? -19.111 -16.076 0.431   1.00 10.20 ?  98   ALA D C   1 
ATOM   6491 O O   . ALA D 2 98  ? -19.568 -14.934 0.253   1.00 11.14 ?  98   ALA D O   1 
ATOM   6492 C CB  . ALA D 2 98  ? -19.120 -17.777 -1.435  1.00 9.42  ?  98   ALA D CB  1 
ATOM   6493 N N   . LYS D 2 99  ? -17.981 -16.329 1.116   1.00 8.80  ?  99   LYS D N   1 
ATOM   6494 C CA  . LYS D 2 99  ? -17.198 -15.256 1.721   1.00 9.99  ?  99   LYS D CA  1 
ATOM   6495 C C   . LYS D 2 99  ? -15.892 -15.083 0.942   1.00 11.49 ?  99   LYS D C   1 
ATOM   6496 O O   . LYS D 2 99  ? -14.989 -15.924 1.033   1.00 10.01 ?  99   LYS D O   1 
ATOM   6497 C CB  . LYS D 2 99  ? -16.940 -15.551 3.199   1.00 10.00 ?  99   LYS D CB  1 
ATOM   6498 C CG  . LYS D 2 99  ? -16.137 -14.415 3.884   1.00 11.28 ?  99   LYS D CG  1 
ATOM   6499 C CD  . LYS D 2 99  ? -17.017 -13.148 4.135   1.00 15.71 ?  99   LYS D CD  1 
ATOM   6500 C CE  . LYS D 2 99  ? -16.177 -12.077 4.869   1.00 20.80 ?  99   LYS D CE  1 
ATOM   6501 N NZ  . LYS D 2 99  ? -16.912 -10.792 4.779   1.00 23.83 ?  99   LYS D NZ  1 
ATOM   6502 N N   . PRO D 2 100 ? -15.718 -14.021 0.165   1.00 11.19 ?  100  PRO D N   1 
ATOM   6503 C CA  . PRO D 2 100 ? -14.397 -13.779 -0.473  1.00 10.24 ?  100  PRO D CA  1 
ATOM   6504 C C   . PRO D 2 100 ? -13.362 -13.429 0.585   1.00 10.40 ?  100  PRO D C   1 
ATOM   6505 O O   . PRO D 2 100 ? -13.718 -12.967 1.690   1.00 13.02 ?  100  PRO D O   1 
ATOM   6506 C CB  . PRO D 2 100 ? -14.671 -12.583 -1.409  1.00 13.37 ?  100  PRO D CB  1 
ATOM   6507 C CG  . PRO D 2 100 ? -16.199 -12.533 -1.524  1.00 12.45 ?  100  PRO D CG  1 
ATOM   6508 C CD  . PRO D 2 100 ? -16.701 -12.979 -0.148  1.00 11.64 ?  100  PRO D CD  1 
ATOM   6509 N N   . PRO D 2 101 ? -12.070 -13.608 0.280   1.00 10.34 ?  101  PRO D N   1 
ATOM   6510 C CA  . PRO D 2 101 ? -11.513 -14.006 -1.017  1.00 10.13 ?  101  PRO D CA  1 
ATOM   6511 C C   . PRO D 2 101 ? -11.374 -15.507 -1.235  1.00 10.82 ?  101  PRO D C   1 
ATOM   6512 O O   . PRO D 2 101 ? -10.975 -15.874 -2.341  1.00 12.80 ?  101  PRO D O   1 
ATOM   6513 C CB  . PRO D 2 101 ? -10.114 -13.362 -0.983  1.00 12.66 ?  101  PRO D CB  1 
ATOM   6514 C CG  . PRO D 2 101 ? -9.771  -13.460 0.450   1.00 12.13 ?  101  PRO D CG  1 
ATOM   6515 C CD  . PRO D 2 101 ? -10.995 -13.273 1.257   1.00 13.22 ?  101  PRO D CD  1 
ATOM   6516 N N   . THR D 2 102 ? -11.611 -16.332 -0.193  1.00 10.83 ?  102  THR D N   1 
ATOM   6517 C CA  . THR D 2 102 ? -11.385 -17.766 -0.379  1.00 9.37  ?  102  THR D CA  1 
ATOM   6518 C C   . THR D 2 102 ? -12.643 -18.520 -0.780  1.00 8.88  ?  102  THR D C   1 
ATOM   6519 O O   . THR D 2 102 ? -12.529 -19.689 -1.146  1.00 8.85  ?  102  THR D O   1 
ATOM   6520 C CB  . THR D 2 102 ? -10.803 -18.472 0.869   1.00 8.93  ?  102  THR D CB  1 
ATOM   6521 O OG1 . THR D 2 102 ? -11.812 -18.615 1.867   1.00 9.91  ?  102  THR D OG1 1 
ATOM   6522 C CG2 . THR D 2 102 ? -9.563  -17.721 1.446   1.00 12.53 ?  102  THR D CG2 1 
ATOM   6523 N N   . TYR D 2 103 ? -13.797 -17.899 -0.659  1.00 9.35  ?  103  TYR D N   1 
ATOM   6524 C CA  . TYR D 2 103 ? -15.086 -18.460 -1.095  1.00 9.91  ?  103  TYR D CA  1 
ATOM   6525 C C   . TYR D 2 103 ? -15.467 -19.729 -0.319  1.00 8.96  ?  103  TYR D C   1 
ATOM   6526 O O   . TYR D 2 103 ? -16.024 -20.662 -0.883  1.00 9.55  ?  103  TYR D O   1 
ATOM   6527 C CB  . TYR D 2 103 ? -15.095 -18.706 -2.633  1.00 10.25 ?  103  TYR D CB  1 
ATOM   6528 C CG  . TYR D 2 103 ? -15.161 -17.362 -3.371  1.00 10.83 ?  103  TYR D CG  1 
ATOM   6529 C CD1 . TYR D 2 103 ? -16.385 -16.771 -3.689  1.00 10.87 ?  103  TYR D CD1 1 
ATOM   6530 C CD2 . TYR D 2 103 ? -13.991 -16.669 -3.662  1.00 11.81 ?  103  TYR D CD2 1 
ATOM   6531 C CE1 . TYR D 2 103 ? -16.419 -15.525 -4.302  1.00 13.10 ?  103  TYR D CE1 1 
ATOM   6532 C CE2 . TYR D 2 103 ? -14.023 -15.417 -4.247  1.00 11.51 ?  103  TYR D CE2 1 
ATOM   6533 C CZ  . TYR D 2 103 ? -15.246 -14.873 -4.574  1.00 13.52 ?  103  TYR D CZ  1 
ATOM   6534 O OH  . TYR D 2 103 ? -15.291 -13.613 -5.147  1.00 16.09 ?  103  TYR D OH  1 
ATOM   6535 N N   . TYR D 2 104 ? -15.242 -19.770 1.005   1.00 7.87  ?  104  TYR D N   1 
ATOM   6536 C CA  . TYR D 2 104 ? -15.986 -20.774 1.765   1.00 9.16  ?  104  TYR D CA  1 
ATOM   6537 C C   . TYR D 2 104 ? -17.479 -20.433 1.697   1.00 7.90  ?  104  TYR D C   1 
ATOM   6538 O O   . TYR D 2 104 ? -17.880 -19.244 1.663   1.00 8.95  ?  104  TYR D O   1 
ATOM   6539 C CB  . TYR D 2 104 ? -15.493 -20.891 3.224   1.00 9.68  ?  104  TYR D CB  1 
ATOM   6540 C CG  . TYR D 2 104 ? -15.573 -19.678 4.150   1.00 8.77  ?  104  TYR D CG  1 
ATOM   6541 C CD1 . TYR D 2 104 ? -16.719 -19.379 4.886   1.00 8.37  ?  104  TYR D CD1 1 
ATOM   6542 C CD2 . TYR D 2 104 ? -14.450 -18.854 4.319   1.00 9.47  ?  104  TYR D CD2 1 
ATOM   6543 C CE1 . TYR D 2 104 ? -16.753 -18.310 5.807   1.00 8.84  ?  104  TYR D CE1 1 
ATOM   6544 C CE2 . TYR D 2 104 ? -14.474 -17.776 5.196   1.00 8.84  ?  104  TYR D CE2 1 
ATOM   6545 C CZ  . TYR D 2 104 ? -15.619 -17.501 5.924   1.00 11.79 ?  104  TYR D CZ  1 
ATOM   6546 O OH  . TYR D 2 104 ? -15.706 -16.455 6.826   1.00 12.03 ?  104  TYR D OH  1 
ATOM   6547 N N   . SER D 2 105 ? -18.299 -21.469 1.650   1.00 7.29  ?  105  SER D N   1 
ATOM   6548 C CA  . SER D 2 105 ? -19.757 -21.285 1.578   1.00 7.52  ?  105  SER D CA  1 
ATOM   6549 C C   . SER D 2 105 ? -20.346 -21.050 2.974   1.00 9.06  ?  105  SER D C   1 
ATOM   6550 O O   . SER D 2 105 ? -19.761 -21.412 4.011   1.00 7.73  ?  105  SER D O   1 
ATOM   6551 C CB  . SER D 2 105 ? -20.421 -22.514 0.946   1.00 8.25  ?  105  SER D CB  1 
ATOM   6552 O OG  . SER D 2 105 ? -20.150 -23.694 1.728   1.00 11.04 ?  105  SER D OG  1 
ATOM   6553 N N   . LEU D 2 106 ? -21.543 -20.432 3.006   1.00 8.51  ?  106  LEU D N   1 
ATOM   6554 C CA  . LEU D 2 106 ? -22.122 -19.951 4.266   1.00 7.57  ?  106  LEU D CA  1 
ATOM   6555 C C   . LEU D 2 106 ? -23.398 -20.679 4.719   1.00 8.21  ?  106  LEU D C   1 
ATOM   6556 O O   . LEU D 2 106 ? -23.687 -20.688 5.936   1.00 8.51  ?  106  LEU D O   1 
ATOM   6557 C CB  . LEU D 2 106 ? -22.456 -18.440 4.156   1.00 10.53 ?  106  LEU D CB  1 
ATOM   6558 C CG  . LEU D 2 106 ? -21.212 -17.585 3.851   1.00 10.33 ?  106  LEU D CG  1 
ATOM   6559 C CD1 . LEU D 2 106 ? -21.659 -16.126 3.719   1.00 11.47 ?  106  LEU D CD1 1 
ATOM   6560 C CD2 . LEU D 2 106 ? -20.165 -17.708 4.984   1.00 12.15 ?  106  LEU D CD2 1 
ATOM   6561 N N   . GLU D 2 107 ? -24.197 -21.255 3.797   1.00 8.11  ?  107  GLU D N   1 
ATOM   6562 C CA  . GLU D 2 107 ? -25.550 -21.700 4.123   1.00 8.32  ?  107  GLU D CA  1 
ATOM   6563 C C   . GLU D 2 107 ? -25.668 -23.205 3.993   1.00 8.56  ?  107  GLU D C   1 
ATOM   6564 O O   . GLU D 2 107 ? -24.960 -23.810 3.188   1.00 8.02  ?  107  GLU D O   1 
ATOM   6565 C CB  . GLU D 2 107 ? -26.583 -21.059 3.175   1.00 8.30  ?  107  GLU D CB  1 
ATOM   6566 C CG  . GLU D 2 107 ? -26.587 -19.536 3.203   1.00 10.13 ?  107  GLU D CG  1 
ATOM   6567 C CD  . GLU D 2 107 ? -27.088 -18.988 4.519   1.00 11.80 ?  107  GLU D CD  1 
ATOM   6568 O OE1 . GLU D 2 107 ? -27.897 -19.694 5.206   1.00 14.05 ?  107  GLU D OE1 1 
ATOM   6569 O OE2 . GLU D 2 107 ? -26.701 -17.827 4.849   1.00 11.71 -1 107  GLU D OE2 1 
ATOM   6570 N N   . PRO D 2 108 ? -26.675 -23.813 4.641   1.00 8.21  ?  108  PRO D N   1 
ATOM   6571 C CA  . PRO D 2 108 ? -27.082 -25.180 4.278   1.00 8.08  ?  108  PRO D CA  1 
ATOM   6572 C C   . PRO D 2 108 ? -27.369 -25.276 2.773   1.00 8.47  ?  108  PRO D C   1 
ATOM   6573 O O   . PRO D 2 108 ? -27.826 -24.303 2.154   1.00 9.64  ?  108  PRO D O   1 
ATOM   6574 C CB  . PRO D 2 108 ? -28.381 -25.380 5.073   1.00 9.31  ?  108  PRO D CB  1 
ATOM   6575 C CG  . PRO D 2 108 ? -28.307 -24.408 6.151   1.00 12.56 ?  108  PRO D CG  1 
ATOM   6576 C CD  . PRO D 2 108 ? -27.505 -23.213 5.692   1.00 7.82  ?  108  PRO D CD  1 
ATOM   6577 N N   . TRP D 2 109 ? -27.075 -26.446 2.189   1.00 9.00  ?  109  TRP D N   1 
ATOM   6578 C CA  . TRP D 2 109 ? -27.125 -26.603 0.729   1.00 8.19  ?  109  TRP D CA  1 
ATOM   6579 C C   . TRP D 2 109 ? -28.540 -26.762 0.157   1.00 9.22  ?  109  TRP D C   1 
ATOM   6580 O O   . TRP D 2 109 ? -29.436 -27.349 0.783   1.00 11.13 ?  109  TRP D O   1 
ATOM   6581 C CB  . TRP D 2 109 ? -26.311 -27.830 0.326   1.00 9.47  ?  109  TRP D CB  1 
ATOM   6582 C CG  . TRP D 2 109 ? -24.841 -27.626 0.703   1.00 8.75  ?  109  TRP D CG  1 
ATOM   6583 C CD1 . TRP D 2 109 ? -24.226 -28.022 1.869   1.00 10.36 ?  109  TRP D CD1 1 
ATOM   6584 C CD2 . TRP D 2 109 ? -23.861 -26.907 -0.055  1.00 8.15  ?  109  TRP D CD2 1 
ATOM   6585 N NE1 . TRP D 2 109 ? -22.890 -27.631 1.858   1.00 11.21 ?  109  TRP D NE1 1 
ATOM   6586 C CE2 . TRP D 2 109 ? -22.655 -26.927 0.695   1.00 9.74  ?  109  TRP D CE2 1 
ATOM   6587 C CE3 . TRP D 2 109 ? -23.877 -26.286 -1.311  1.00 7.33  ?  109  TRP D CE3 1 
ATOM   6588 C CZ2 . TRP D 2 109 ? -21.490 -26.316 0.257   1.00 8.93  ?  109  TRP D CZ2 1 
ATOM   6589 C CZ3 . TRP D 2 109 ? -22.709 -25.654 -1.760  1.00 6.30  ?  109  TRP D CZ3 1 
ATOM   6590 C CH2 . TRP D 2 109 ? -21.518 -25.705 -0.998  1.00 7.98  ?  109  TRP D CH2 1 
ATOM   6591 N N   . GLY D 2 110 ? -28.705 -26.296 -1.082  1.00 9.12  ?  110  GLY D N   1 
ATOM   6592 C CA  . GLY D 2 110 ? -29.839 -26.699 -1.893  1.00 8.82  ?  110  GLY D CA  1 
ATOM   6593 C C   . GLY D 2 110 ? -29.667 -28.131 -2.397  1.00 8.27  ?  110  GLY D C   1 
ATOM   6594 O O   . GLY D 2 110 ? -28.738 -28.851 -2.039  1.00 9.68  ?  110  GLY D O   1 
ATOM   6595 N N   . LYS D 2 111 ? -30.589 -28.536 -3.282  1.00 10.04 ?  111  LYS D N   1 
ATOM   6596 C CA  . LYS D 2 111 ? -30.567 -29.917 -3.762  1.00 12.65 ?  111  LYS D CA  1 
ATOM   6597 C C   . LYS D 2 111 ? -29.510 -30.160 -4.819  1.00 10.86 ?  111  LYS D C   1 
ATOM   6598 O O   . LYS D 2 111 ? -29.147 -31.319 -5.052  1.00 13.00 ?  111  LYS D O   1 
ATOM   6599 C CB  . LYS D 2 111 ? -31.952 -30.297 -4.324  1.00 14.44 ?  111  LYS D CB  1 
ATOM   6600 C CG  . LYS D 2 111 ? -32.990 -30.356 -3.195  1.00 19.13 ?  111  LYS D CG  1 
ATOM   6601 C CD  . LYS D 2 111 ? -34.453 -30.358 -3.737  1.00 30.04 ?  111  LYS D CD  1 
ATOM   6602 C CE  . LYS D 2 111 ? -34.690 -29.136 -4.695  1.00 34.89 ?  111  LYS D CE  1 
ATOM   6603 N NZ  . LYS D 2 111 ? -35.862 -28.204 -4.414  1.00 36.10 ?  111  LYS D NZ  1 
ATOM   6604 N N   . GLY D 2 112 ? -28.965 -29.098 -5.405  1.00 9.08  ?  112  GLY D N   1 
ATOM   6605 C CA  . GLY D 2 112 ? -27.986 -29.229 -6.467  1.00 9.72  ?  112  GLY D CA  1 
ATOM   6606 C C   . GLY D 2 112 ? -28.612 -29.691 -7.799  1.00 9.59  ?  112  GLY D C   1 
ATOM   6607 O O   . GLY D 2 112 ? -29.817 -29.959 -7.913  1.00 10.96 ?  112  GLY D O   1 
ATOM   6608 N N   . THR D 2 113 ? -27.756 -29.811 -8.821  1.00 9.09  ?  113  THR D N   1 
ATOM   6609 C CA  . THR D 2 113 ? -28.208 -30.269 -10.144 1.00 7.43  ?  113  THR D CA  1 
ATOM   6610 C C   . THR D 2 113 ? -27.120 -31.180 -10.742 1.00 9.33  ?  113  THR D C   1 
ATOM   6611 O O   . THR D 2 113 ? -25.914 -30.858 -10.710 1.00 8.85  ?  113  THR D O   1 
ATOM   6612 C CB  . THR D 2 113 ? -28.570 -29.096 -11.052 1.00 10.79 ?  113  THR D CB  1 
ATOM   6613 O OG1 . THR D 2 113 ? -29.224 -29.585 -12.257 1.00 11.94 ?  113  THR D OG1 1 
ATOM   6614 C CG2 . THR D 2 113 ? -27.350 -28.261 -11.443 1.00 9.98  ?  113  THR D CG2 1 
ATOM   6615 N N   . GLN D 2 114 ? -27.552 -32.349 -11.240 1.00 9.46  ?  114  GLN D N   1 
ATOM   6616 C CA  . GLN D 2 114 ? -26.635 -33.387 -11.742 1.00 10.71 ?  114  GLN D CA  1 
ATOM   6617 C C   . GLN D 2 114 ? -26.133 -33.031 -13.132 1.00 10.83 ?  114  GLN D C   1 
ATOM   6618 O O   . GLN D 2 114 ? -26.935 -32.693 -14.027 1.00 11.39 ?  114  GLN D O   1 
ATOM   6619 C CB  . GLN D 2 114 ? -27.341 -34.750 -11.820 1.00 11.36 ?  114  GLN D CB  1 
ATOM   6620 C CG  . GLN D 2 114 ? -26.451 -35.843 -12.459 1.00 11.53 ?  114  GLN D CG  1 
ATOM   6621 C CD  . GLN D 2 114 ? -25.412 -36.304 -11.479 1.00 15.85 ?  114  GLN D CD  1 
ATOM   6622 O OE1 . GLN D 2 114 ? -25.721 -36.565 -10.310 1.00 14.19 ?  114  GLN D OE1 1 
ATOM   6623 N NE2 . GLN D 2 114 ? -24.151 -36.408 -11.939 1.00 11.18 ?  114  GLN D NE2 1 
ATOM   6624 N N   . VAL D 2 115 ? -24.797 -33.087 -13.320 1.00 8.79  ?  115  VAL D N   1 
ATOM   6625 C CA  . VAL D 2 115 ? -24.175 -32.964 -14.640 1.00 8.06  ?  115  VAL D CA  1 
ATOM   6626 C C   . VAL D 2 115 ? -23.395 -34.252 -14.898 1.00 8.41  ?  115  VAL D C   1 
ATOM   6627 O O   . VAL D 2 115 ? -22.549 -34.642 -14.084 1.00 8.77  ?  115  VAL D O   1 
ATOM   6628 C CB  . VAL D 2 115 ? -23.230 -31.749 -14.745 1.00 9.19  ?  115  VAL D CB  1 
ATOM   6629 C CG1 . VAL D 2 115 ? -22.531 -31.749 -16.134 1.00 9.40  ?  115  VAL D CG1 1 
ATOM   6630 C CG2 . VAL D 2 115 ? -24.013 -30.401 -14.554 1.00 9.62  ?  115  VAL D CG2 1 
ATOM   6631 N N   . THR D 2 116 ? -23.735 -34.967 -15.982 1.00 10.18 ?  116  THR D N   1 
ATOM   6632 C CA  . THR D 2 116 ? -23.007 -36.183 -16.324 1.00 8.40  ?  116  THR D CA  1 
ATOM   6633 C C   . THR D 2 116 ? -22.477 -36.001 -17.737 1.00 9.55  ?  116  THR D C   1 
ATOM   6634 O O   . THR D 2 116 ? -23.251 -35.726 -18.664 1.00 9.24  ?  116  THR D O   1 
ATOM   6635 C CB  . THR D 2 116 ? -23.902 -37.439 -16.228 1.00 10.26 ?  116  THR D CB  1 
ATOM   6636 O OG1 . THR D 2 116 ? -24.340 -37.583 -14.884 1.00 10.19 ?  116  THR D OG1 1 
ATOM   6637 C CG2 . THR D 2 116 ? -23.128 -38.705 -16.637 1.00 10.99 ?  116  THR D CG2 1 
ATOM   6638 N N   . VAL D 2 117 ? -21.161 -36.162 -17.909 1.00 10.54 ?  117  VAL D N   1 
ATOM   6639 C CA  . VAL D 2 117 ? -20.525 -35.938 -19.204 1.00 12.16 ?  117  VAL D CA  1 
ATOM   6640 C C   . VAL D 2 117 ? -20.158 -37.298 -19.761 1.00 14.35 ?  117  VAL D C   1 
ATOM   6641 O O   . VAL D 2 117 ? -19.371 -38.030 -19.153 1.00 15.41 ?  117  VAL D O   1 
ATOM   6642 C CB  . VAL D 2 117 ? -19.278 -35.046 -19.075 1.00 11.47 ?  117  VAL D CB  1 
ATOM   6643 C CG1 . VAL D 2 117 ? -18.647 -34.860 -20.508 1.00 13.86 ?  117  VAL D CG1 1 
ATOM   6644 C CG2 . VAL D 2 117 ? -19.613 -33.700 -18.396 1.00 12.45 ?  117  VAL D CG2 1 
ATOM   6645 N N   . SER D 2 118 ? -20.744 -37.650 -20.903 1.00 13.31 ?  118  SER D N   1 
ATOM   6646 C CA  . SER D 2 118 ? -20.575 -38.992 -21.423 1.00 18.58 ?  118  SER D CA  1 
ATOM   6647 C C   . SER D 2 118 ? -19.154 -39.176 -21.971 1.00 25.31 ?  118  SER D C   1 
ATOM   6648 O O   . SER D 2 118 ? -18.526 -38.234 -22.460 1.00 24.97 ?  118  SER D O   1 
ATOM   6649 C CB  . SER D 2 118 ? -21.649 -39.235 -22.488 1.00 22.70 ?  118  SER D CB  1 
ATOM   6650 O OG  . SER D 2 118 ? -21.363 -40.402 -23.238 1.00 30.87 ?  118  SER D OG  1 
ATOM   6651 N N   . SER D 2 119 ? -18.630 -40.393 -21.836 1.00 30.56 ?  119  SER D N   1 
ATOM   6652 C CA  . SER D 2 119 ? -17.325 -40.747 -22.381 1.00 41.28 ?  119  SER D CA  1 
ATOM   6653 C C   . SER D 2 119 ? -17.445 -41.491 -23.704 1.00 44.82 ?  119  SER D C   1 
ATOM   6654 O O   . SER D 2 119 ? -16.588 -42.325 -24.026 1.00 51.60 ?  119  SER D O   1 
ATOM   6655 C CB  . SER D 2 119 ? -16.533 -41.581 -21.375 1.00 40.35 ?  119  SER D CB  1 
ATOM   6656 O OG  . SER D 2 119 ? -17.327 -42.636 -20.843 1.00 45.68 ?  119  SER D OG  1 
ATOM   6657 N N   . HIS D 2 120 ? -18.495 -41.203 -24.472 1.00 43.24 ?  120  HIS D N   1 
ATOM   6658 C CA  . HIS D 2 120 ? -18.765 -41.867 -25.751 1.00 46.38 ?  120  HIS D CA  1 
ATOM   6659 C C   . HIS D 2 120 ? -18.950 -40.810 -26.851 1.00 48.54 ?  120  HIS D C   1 
ATOM   6660 O O   . HIS D 2 120 ? -18.258 -40.814 -27.874 1.00 59.21 ?  120  HIS D O   1 
ATOM   6661 C CB  . HIS D 2 120 ? -20.025 -42.750 -25.660 1.00 39.90 ?  120  HIS D CB  1 
ATOM   6662 C CG  . HIS D 2 120 ? -19.982 -43.789 -24.576 1.00 37.17 ?  120  HIS D CG  1 
ATOM   6663 N ND1 . HIS D 2 120 ? -20.763 -43.715 -23.441 1.00 34.10 ?  120  HIS D ND1 1 
ATOM   6664 C CD2 . HIS D 2 120 ? -19.268 -44.936 -24.462 1.00 36.95 ?  120  HIS D CD2 1 
ATOM   6665 C CE1 . HIS D 2 120 ? -20.532 -44.766 -22.674 1.00 37.04 ?  120  HIS D CE1 1 
ATOM   6666 N NE2 . HIS D 2 120 ? -19.625 -45.519 -23.268 1.00 41.59 ?  120  HIS D NE2 1 
HETATM 6667 C C1  . GOL E 3 .   ? -4.585  -44.278 39.287  1.00 25.91 ?  601  GOL A C1  1 
HETATM 6668 O O1  . GOL E 3 .   ? -3.692  -45.409 39.359  1.00 28.21 ?  601  GOL A O1  1 
HETATM 6669 C C2  . GOL E 3 .   ? -5.842  -44.830 38.571  1.00 19.99 ?  601  GOL A C2  1 
HETATM 6670 O O2  . GOL E 3 .   ? -6.403  -45.937 39.196  1.00 19.09 ?  601  GOL A O2  1 
HETATM 6671 C C3  . GOL E 3 .   ? -6.839  -43.665 38.403  1.00 16.45 ?  601  GOL A C3  1 
HETATM 6672 O O3  . GOL E 3 .   ? -6.118  -42.539 37.871  1.00 19.04 ?  601  GOL A O3  1 
HETATM 6673 C C1  . GOL F 3 .   ? -3.511  -38.009 37.008  1.00 25.53 ?  602  GOL A C1  1 
HETATM 6674 O O1  . GOL F 3 .   ? -3.047  -39.153 36.387  1.00 34.83 ?  602  GOL A O1  1 
HETATM 6675 C C2  . GOL F 3 .   ? -4.127  -37.131 35.914  1.00 21.69 ?  602  GOL A C2  1 
HETATM 6676 O O2  . GOL F 3 .   ? -3.263  -37.032 34.906  1.00 22.21 ?  602  GOL A O2  1 
HETATM 6677 C C3  . GOL F 3 .   ? -5.542  -37.787 35.355  1.00 19.57 ?  602  GOL A C3  1 
HETATM 6678 O O3  . GOL F 3 .   ? -6.138  -36.842 34.303  1.00 16.50 ?  602  GOL A O3  1 
HETATM 6679 C C1  . IPA G 4 .   ? -35.301 -34.790 50.182  1.00 24.27 ?  603  IPA A C1  1 
HETATM 6680 C C2  . IPA G 4 .   ? -35.950 -33.476 49.786  1.00 24.74 ?  603  IPA A C2  1 
HETATM 6681 C C3  . IPA G 4 .   ? -34.931 -32.356 49.902  1.00 27.99 ?  603  IPA A C3  1 
HETATM 6682 O O2  . IPA G 4 .   ? -36.788 -33.562 48.625  1.00 24.03 ?  603  IPA A O2  1 
HETATM 6683 C C1  . GOL H 3 .   ? -3.402  -36.679 30.864  1.00 22.46 ?  604  GOL A C1  1 
HETATM 6684 O O1  . GOL H 3 .   ? -2.986  -37.416 31.986  1.00 36.03 ?  604  GOL A O1  1 
HETATM 6685 C C2  . GOL H 3 .   ? -4.976  -36.518 31.063  1.00 25.56 ?  604  GOL A C2  1 
HETATM 6686 O O2  . GOL H 3 .   ? -5.392  -36.215 32.392  1.00 27.46 ?  604  GOL A O2  1 
HETATM 6687 C C3  . GOL H 3 .   ? -5.642  -37.856 30.606  1.00 30.04 ?  604  GOL A C3  1 
HETATM 6688 O O3  . GOL H 3 .   ? -7.024  -37.521 30.526  1.00 24.38 ?  604  GOL A O3  1 
HETATM 6689 C C1  . EDO I 5 .   ? -22.358 -18.391 36.885  1.00 26.77 ?  605  EDO A C1  1 
HETATM 6690 O O1  . EDO I 5 .   ? -22.919 -18.189 35.598  1.00 33.12 ?  605  EDO A O1  1 
HETATM 6691 C C2  . EDO I 5 .   ? -21.580 -19.686 36.769  1.00 20.00 ?  605  EDO A C2  1 
HETATM 6692 O O2  . EDO I 5 .   ? -22.558 -20.698 36.575  1.00 22.12 ?  605  EDO A O2  1 
HETATM 6693 C C1  . EDO J 5 .   ? -32.222 -34.741 29.757  1.00 30.65 ?  606  EDO A C1  1 
HETATM 6694 O O1  . EDO J 5 .   ? -31.613 -33.617 30.382  1.00 33.48 ?  606  EDO A O1  1 
HETATM 6695 C C2  . EDO J 5 .   ? -33.692 -34.796 30.167  1.00 28.82 ?  606  EDO A C2  1 
HETATM 6696 O O2  . EDO J 5 .   ? -34.416 -34.075 29.153  1.00 35.21 ?  606  EDO A O2  1 
HETATM 6697 H H11 . EDO J 5 .   ? -31.715 -35.659 30.061  1.00 36.80 ?  606  EDO A H11 1 
HETATM 6698 H H12 . EDO J 5 .   ? -32.140 -34.655 28.671  1.00 36.80 ?  606  EDO A H12 1 
HETATM 6699 H HO1 . EDO J 5 .   ? -31.002 -33.195 29.762  1.00 40.20 ?  606  EDO A HO1 1 
HETATM 6700 H H21 . EDO J 5 .   ? -33.838 -34.336 31.146  1.00 34.61 ?  606  EDO A H21 1 
HETATM 6701 H H22 . EDO J 5 .   ? -34.038 -35.830 30.227  1.00 34.61 ?  606  EDO A H22 1 
HETATM 6702 H HO2 . EDO J 5 .   ? -34.890 -33.336 29.559  1.00 42.28 ?  606  EDO A HO2 1 
HETATM 6703 C C1  . EDO K 5 .   ? -1.431  -34.788 21.503  1.00 25.29 ?  607  EDO A C1  1 
HETATM 6704 O O1  . EDO K 5 .   ? -2.085  -34.478 22.734  1.00 25.37 ?  607  EDO A O1  1 
HETATM 6705 C C2  . EDO K 5 .   ? -2.248  -34.461 20.257  1.00 22.59 ?  607  EDO A C2  1 
HETATM 6706 O O2  . EDO K 5 .   ? -1.270  -34.281 19.220  1.00 33.68 ?  607  EDO A O2  1 
HETATM 6707 H H11 . EDO K 5 .   ? -1.194  -35.854 21.493  1.00 30.37 ?  607  EDO A H11 1 
HETATM 6708 H H12 . EDO K 5 .   ? -0.491  -34.234 21.458  1.00 30.37 ?  607  EDO A H12 1 
HETATM 6709 H HO1 . EDO K 5 .   ? -1.630  -33.740 23.163  1.00 30.47 ?  607  EDO A HO1 1 
HETATM 6710 H H21 . EDO K 5 .   ? -2.838  -33.554 20.401  1.00 27.14 ?  607  EDO A H21 1 
HETATM 6711 H H22 . EDO K 5 .   ? -2.935  -35.274 20.013  1.00 27.14 ?  607  EDO A H22 1 
HETATM 6712 H HO2 . EDO K 5 .   ? -1.588  -34.691 18.403  1.00 40.44 ?  607  EDO A HO2 1 
HETATM 6713 C C1  . GOL L 3 .   ? -21.577 -13.144 32.490  1.00 29.82 ?  601  GOL B C1  1 
HETATM 6714 O O1  . GOL L 3 .   ? -21.727 -11.756 32.718  1.00 35.31 ?  601  GOL B O1  1 
HETATM 6715 C C2  . GOL L 3 .   ? -20.477 -13.231 31.399  1.00 24.61 ?  601  GOL B C2  1 
HETATM 6716 O O2  . GOL L 3 .   ? -20.733 -12.489 30.238  1.00 22.97 ?  601  GOL B O2  1 
HETATM 6717 C C3  . GOL L 3 .   ? -20.163 -14.734 31.142  1.00 14.83 ?  601  GOL B C3  1 
HETATM 6718 O O3  . GOL L 3 .   ? -20.720 -15.591 32.152  1.00 18.86 ?  601  GOL B O3  1 
HETATM 6719 C C1  . EDO M 5 .   ? -2.527  -17.313 15.706  1.00 26.08 ?  602  EDO B C1  1 
HETATM 6720 O O1  . EDO M 5 .   ? -2.068  -18.002 14.512  1.00 23.26 ?  602  EDO B O1  1 
HETATM 6721 C C2  . EDO M 5 .   ? -3.607  -18.064 16.515  1.00 11.70 ?  602  EDO B C2  1 
HETATM 6722 O O2  . EDO M 5 .   ? -4.247  -18.805 15.547  1.00 19.31 ?  602  EDO B O2  1 
HETATM 6723 S S   . DMS N 6 .   ? -41.974 -30.786 13.924  1.00 44.86 ?  603  DMS B S   1 
HETATM 6724 O O   . DMS N 6 .   ? -42.031 -29.927 12.722  1.00 18.44 ?  603  DMS B O   1 
HETATM 6725 C C1  . DMS N 6 .   ? -40.364 -31.426 14.323  1.00 12.72 ?  603  DMS B C1  1 
HETATM 6726 C C2  . DMS N 6 .   ? -42.728 -32.403 13.675  1.00 16.00 ?  603  DMS B C2  1 
HETATM 6727 H H11 . DMS N 6 .   ? -40.463 -32.233 15.001  1.00 15.29 ?  603  DMS B H11 1 
HETATM 6728 H H12 . DMS N 6 .   ? -39.781 -30.662 14.768  1.00 15.29 ?  603  DMS B H12 1 
HETATM 6729 H H13 . DMS N 6 .   ? -39.888 -31.764 13.440  1.00 15.29 ?  603  DMS B H13 1 
HETATM 6730 H H21 . DMS N 6 .   ? -42.768 -32.920 14.598  1.00 19.22 ?  603  DMS B H21 1 
HETATM 6731 H H22 . DMS N 6 .   ? -42.149 -32.960 12.984  1.00 19.22 ?  603  DMS B H22 1 
HETATM 6732 H H23 . DMS N 6 .   ? -43.709 -32.282 13.295  1.00 19.22 ?  603  DMS B H23 1 
HETATM 6733 C C1  . EDO O 5 .   ? 0.070   -22.651 12.526  1.00 24.72 ?  604  EDO B C1  1 
HETATM 6734 O O1  . EDO O 5 .   ? -0.248  -21.313 12.092  1.00 37.85 ?  604  EDO B O1  1 
HETATM 6735 C C2  . EDO O 5 .   ? -1.263  -23.386 12.441  1.00 25.49 ?  604  EDO B C2  1 
HETATM 6736 O O2  . EDO O 5 .   ? -1.131  -24.713 11.928  1.00 23.64 ?  604  EDO B O2  1 
HETATM 6737 H H11 . EDO O 5 .   ? 0.460   -22.655 13.546  1.00 29.69 ?  604  EDO B H11 1 
HETATM 6738 H H12 . EDO O 5 .   ? 0.819   -23.110 11.878  1.00 29.69 ?  604  EDO B H12 1 
HETATM 6739 H HO1 . EDO O 5 .   ? 0.324   -21.070 11.351  1.00 45.44 ?  604  EDO B HO1 1 
HETATM 6740 H H21 . EDO O 5 .   ? -1.940  -22.821 11.796  1.00 30.62 ?  604  EDO B H21 1 
HETATM 6741 H H22 . EDO O 5 .   ? -1.708  -23.432 13.437  1.00 30.62 ?  604  EDO B H22 1 
HETATM 6742 H HO2 . EDO O 5 .   ? -1.945  -24.964 11.470  1.00 28.40 ?  604  EDO B HO2 1 
HETATM 6743 C C1  . EDO P 5 .   ? -18.341 -14.185 39.128  1.00 28.06 ?  605  EDO B C1  1 
HETATM 6744 O O1  . EDO P 5 .   ? -17.984 -12.837 39.453  1.00 35.47 ?  605  EDO B O1  1 
HETATM 6745 C C2  . EDO P 5 .   ? -18.212 -14.473 37.629  1.00 20.33 ?  605  EDO B C2  1 
HETATM 6746 O O2  . EDO P 5 .   ? -18.804 -13.514 36.751  1.00 38.21 ?  605  EDO B O2  1 
HETATM 6747 H H11 . EDO P 5 .   ? -19.370 -14.369 39.441  1.00 33.70 ?  605  EDO B H11 1 
HETATM 6748 H H12 . EDO P 5 .   ? -17.694 -14.869 39.681  1.00 33.70 ?  605  EDO B H12 1 
HETATM 6749 H HO1 . EDO P 5 .   ? -17.505 -12.442 38.712  1.00 42.59 ?  605  EDO B HO1 1 
HETATM 6750 H H21 . EDO P 5 .   ? -18.669 -15.444 37.429  1.00 24.42 ?  605  EDO B H21 1 
HETATM 6751 H H22 . EDO P 5 .   ? -17.150 -14.546 37.387  1.00 24.42 ?  605  EDO B H22 1 
HETATM 6752 H HO2 . EDO P 5 .   ? -18.826 -13.870 35.852  1.00 45.88 ?  605  EDO B HO2 1 
HETATM 6753 C C1  . EDO Q 5 .   ? -9.649  -32.254 -9.087  1.00 25.84 ?  201  EDO D C1  1 
HETATM 6754 O O1  . EDO Q 5 .   ? -10.209 -32.231 -7.762  1.00 24.08 ?  201  EDO D O1  1 
HETATM 6755 C C2  . EDO Q 5 .   ? -10.587 -31.658 -10.134 1.00 22.21 ?  201  EDO D C2  1 
HETATM 6756 O O2  . EDO Q 5 .   ? -11.856 -32.371 -10.078 1.00 21.20 ?  201  EDO D O2  1 
HETATM 6757 C C1  . GOL R 3 .   ? -24.579 -30.492 -27.232 1.00 32.04 ?  202  GOL D C1  1 
HETATM 6758 O O1  . GOL R 3 .   ? -23.589 -31.499 -26.963 1.00 31.81 ?  202  GOL D O1  1 
HETATM 6759 C C2  . GOL R 3 .   ? -24.303 -29.310 -26.239 1.00 27.49 ?  202  GOL D C2  1 
HETATM 6760 O O2  . GOL R 3 .   ? -23.105 -28.706 -26.546 1.00 28.93 ?  202  GOL D O2  1 
HETATM 6761 C C3  . GOL R 3 .   ? -25.489 -28.330 -26.469 1.00 32.27 ?  202  GOL D C3  1 
HETATM 6762 O O3  . GOL R 3 .   ? -25.613 -27.477 -25.290 1.00 34.34 ?  202  GOL D O3  1 
HETATM 6763 C C1  . IPA S 4 .   ? -25.292 -37.670 -24.761 1.00 24.09 ?  203  IPA D C1  1 
HETATM 6764 C C2  . IPA S 4 .   ? -25.944 -36.368 -25.222 1.00 27.06 ?  203  IPA D C2  1 
HETATM 6765 C C3  . IPA S 4 .   ? -25.536 -36.096 -26.663 1.00 17.67 ?  203  IPA D C3  1 
HETATM 6766 O O2  . IPA S 4 .   ? -27.359 -36.304 -25.012 1.00 25.92 ?  203  IPA D O2  1 
HETATM 6767 O O   . HOH T 7 .   ? -20.878 -47.572 59.331  1.00 37.63 ?  701  HOH A O   1 
HETATM 6768 O O   . HOH T 7 .   ? -20.328 -41.320 61.245  1.00 29.29 ?  702  HOH A O   1 
HETATM 6769 O O   . HOH T 7 .   ? -25.627 -41.884 66.526  1.00 37.63 ?  703  HOH A O   1 
HETATM 6770 O O   . HOH T 7 .   ? -3.824  -41.628 37.569  1.00 25.71 ?  704  HOH A O   1 
HETATM 6771 O O   . HOH T 7 .   ? -33.925 -36.405 41.319  1.00 22.44 ?  705  HOH A O   1 
HETATM 6772 O O   . HOH T 7 .   ? -1.211  -31.885 18.455  1.00 22.86 ?  706  HOH A O   1 
HETATM 6773 O O   . HOH T 7 .   ? -2.352  -44.648 5.616   1.00 27.50 ?  707  HOH A O   1 
HETATM 6774 O O   . HOH T 7 .   ? -29.075 -23.354 37.862  1.00 33.49 ?  708  HOH A O   1 
HETATM 6775 O O   . HOH T 7 .   ? -24.687 -50.427 47.657  1.00 26.06 ?  709  HOH A O   1 
HETATM 6776 O O   . HOH T 7 .   ? -38.397 -59.040 31.816  1.00 34.43 ?  710  HOH A O   1 
HETATM 6777 O O   . HOH T 7 .   ? -35.665 -43.500 36.595  1.00 25.20 ?  711  HOH A O   1 
HETATM 6778 O O   . HOH T 7 .   ? -34.475 -34.093 59.416  1.00 33.16 ?  712  HOH A O   1 
HETATM 6779 O O   . HOH T 7 .   ? -2.979  -37.733 0.410   1.00 32.91 ?  713  HOH A O   1 
HETATM 6780 O O   . HOH T 7 .   ? -13.919 -69.680 32.552  1.00 25.21 ?  714  HOH A O   1 
HETATM 6781 O O   . HOH T 7 .   ? -15.009 -41.182 61.101  1.00 27.06 ?  715  HOH A O   1 
HETATM 6782 O O   . HOH T 7 .   ? 0.141   -33.360 23.454  1.00 18.04 ?  716  HOH A O   1 
HETATM 6783 O O   . HOH T 7 .   ? -17.135 -56.522 43.581  1.00 32.74 ?  717  HOH A O   1 
HETATM 6784 O O   . HOH T 7 .   ? -7.381  -34.584 31.986  1.00 13.86 ?  718  HOH A O   1 
HETATM 6785 O O   . HOH T 7 .   ? -19.996 -21.549 52.340  1.00 34.19 ?  719  HOH A O   1 
HETATM 6786 O O   . HOH T 7 .   ? -23.305 -45.514 55.811  1.00 25.66 ?  720  HOH A O   1 
HETATM 6787 O O   . HOH T 7 .   ? -3.918  -34.138 24.561  1.00 15.76 ?  721  HOH A O   1 
HETATM 6788 O O   . HOH T 7 .   ? -32.859 -48.470 52.277  1.00 25.59 ?  722  HOH A O   1 
HETATM 6789 O O   . HOH T 7 .   ? -12.499 -44.677 26.670  1.00 15.76 ?  723  HOH A O   1 
HETATM 6790 O O   . HOH T 7 .   ? -39.470 -35.766 44.838  1.00 25.77 ?  724  HOH A O   1 
HETATM 6791 O O   . HOH T 7 .   ? -34.776 -39.556 38.721  1.00 17.99 ?  725  HOH A O   1 
HETATM 6792 O O   . HOH T 7 .   ? -4.582  -49.067 10.852  1.00 12.81 ?  726  HOH A O   1 
HETATM 6793 O O   . HOH T 7 .   ? -22.855 -21.020 54.663  1.00 38.17 ?  727  HOH A O   1 
HETATM 6794 O O   . HOH T 7 .   ? -4.537  -35.486 22.331  1.00 24.19 ?  728  HOH A O   1 
HETATM 6795 O O   . HOH T 7 .   ? -5.514  -34.725 -1.726  1.00 20.94 ?  729  HOH A O   1 
HETATM 6796 O O   . HOH T 7 .   ? -8.801  -55.598 6.898   1.00 31.05 ?  730  HOH A O   1 
HETATM 6797 O O   . HOH T 7 .   ? -23.905 -19.496 40.624  1.00 28.36 ?  731  HOH A O   1 
HETATM 6798 O O   . HOH T 7 .   ? -7.336  -30.097 6.645   1.00 8.82  ?  732  HOH A O   1 
HETATM 6799 O O   . HOH T 7 .   ? -26.363 -21.912 57.319  1.00 30.47 ?  733  HOH A O   1 
HETATM 6800 O O   . HOH T 7 .   ? -11.094 -52.887 44.956  1.00 27.57 ?  734  HOH A O   1 
HETATM 6801 O O   . HOH T 7 .   ? -24.708 -52.974 47.004  1.00 21.04 ?  735  HOH A O   1 
HETATM 6802 O O   . HOH T 7 .   ? -14.046 -47.857 33.286  1.00 9.07  ?  736  HOH A O   1 
HETATM 6803 O O   . HOH T 7 .   ? -0.307  -42.702 17.355  1.00 27.30 ?  737  HOH A O   1 
HETATM 6804 O O   . HOH T 7 .   ? -27.737 -51.608 17.526  1.00 14.33 ?  738  HOH A O   1 
HETATM 6805 O O   . HOH T 7 .   ? -2.794  -26.144 43.664  1.00 28.24 ?  739  HOH A O   1 
HETATM 6806 O O   . HOH T 7 .   ? -41.821 -49.684 19.055  1.00 31.73 ?  740  HOH A O   1 
HETATM 6807 O O   . HOH T 7 .   ? -5.790  -38.348 54.605  1.00 26.02 ?  741  HOH A O   1 
HETATM 6808 O O   . HOH T 7 .   ? -27.203 -34.030 31.428  1.00 12.57 ?  742  HOH A O   1 
HETATM 6809 O O   . HOH T 7 .   ? -42.391 -45.332 19.931  1.00 24.84 ?  743  HOH A O   1 
HETATM 6810 O O   . HOH T 7 .   ? -38.335 -52.287 24.294  1.00 16.84 ?  744  HOH A O   1 
HETATM 6811 O O   . HOH T 7 .   ? -31.613 -29.664 36.666  1.00 22.95 ?  745  HOH A O   1 
HETATM 6812 O O   . HOH T 7 .   ? -7.470  -31.529 56.891  1.00 23.40 ?  746  HOH A O   1 
HETATM 6813 O O   . HOH T 7 .   ? -21.050 -21.359 42.075  1.00 18.07 ?  747  HOH A O   1 
HETATM 6814 O O   . HOH T 7 .   ? -19.129 -45.252 2.710   1.00 27.13 ?  748  HOH A O   1 
HETATM 6815 O O   . HOH T 7 .   ? -44.205 -48.321 24.327  1.00 29.81 ?  749  HOH A O   1 
HETATM 6816 O O   . HOH T 7 .   ? -8.657  -60.027 39.267  1.00 17.52 ?  750  HOH A O   1 
HETATM 6817 O O   . HOH T 7 .   ? -34.171 -41.728 32.457  1.00 31.25 ?  751  HOH A O   1 
HETATM 6818 O O   . HOH T 7 .   ? -32.198 -49.283 18.363  1.00 20.13 ?  752  HOH A O   1 
HETATM 6819 O O   . HOH T 7 .   ? -33.764 -25.940 37.637  1.00 28.34 ?  753  HOH A O   1 
HETATM 6820 O O   . HOH T 7 .   ? -11.317 -58.241 32.040  1.00 12.08 ?  754  HOH A O   1 
HETATM 6821 O O   . HOH T 7 .   ? -12.182 -48.863 5.023   1.00 15.27 ?  755  HOH A O   1 
HETATM 6822 O O   . HOH T 7 .   ? -9.752  -27.905 50.796  1.00 16.84 ?  756  HOH A O   1 
HETATM 6823 O O   . HOH T 7 .   ? -17.851 -56.613 28.439  1.00 11.26 ?  757  HOH A O   1 
HETATM 6824 O O   . HOH T 7 .   ? -31.395 -55.228 22.811  1.00 13.61 ?  758  HOH A O   1 
HETATM 6825 O O   . HOH T 7 .   ? -11.034 -56.567 17.068  1.00 24.56 ?  759  HOH A O   1 
HETATM 6826 O O   . HOH T 7 .   ? -10.720 -35.783 11.804  1.00 7.13  ?  760  HOH A O   1 
HETATM 6827 O O   . HOH T 7 .   ? -25.942 -44.115 8.470   1.00 34.42 ?  761  HOH A O   1 
HETATM 6828 O O   . HOH T 7 .   ? -16.030 -39.410 3.053   1.00 26.56 ?  762  HOH A O   1 
HETATM 6829 O O   . HOH T 7 .   ? -15.712 -53.488 21.192  1.00 10.50 ?  763  HOH A O   1 
HETATM 6830 O O   . HOH T 7 .   ? -28.249 -13.804 48.273  1.00 35.10 ?  764  HOH A O   1 
HETATM 6831 O O   . HOH T 7 .   ? -9.703  -40.705 26.140  1.00 20.74 ?  765  HOH A O   1 
HETATM 6832 O O   . HOH T 7 .   ? -14.767 -47.295 49.274  1.00 23.65 ?  766  HOH A O   1 
HETATM 6833 O O   . HOH T 7 .   ? -9.482  -56.597 10.568  1.00 31.82 ?  767  HOH A O   1 
HETATM 6834 O O   . HOH T 7 .   ? -32.662 -46.574 36.512  1.00 16.32 ?  768  HOH A O   1 
HETATM 6835 O O   . HOH T 7 .   ? -2.533  -44.037 31.735  1.00 36.35 ?  769  HOH A O   1 
HETATM 6836 O O   . HOH T 7 .   ? -26.380 -53.548 26.648  1.00 21.17 ?  770  HOH A O   1 
HETATM 6837 O O   . HOH T 7 .   ? -38.741 -42.502 49.252  1.00 24.07 ?  771  HOH A O   1 
HETATM 6838 O O   . HOH T 7 .   ? -3.644  -39.074 10.496  1.00 12.71 ?  772  HOH A O   1 
HETATM 6839 O O   . HOH T 7 .   ? -15.197 -62.132 31.949  1.00 19.50 ?  773  HOH A O   1 
HETATM 6840 O O   . HOH T 7 .   ? -9.316  -55.038 34.048  1.00 11.18 ?  774  HOH A O   1 
HETATM 6841 O O   . HOH T 7 .   ? -13.568 -25.715 55.004  1.00 30.69 ?  775  HOH A O   1 
HETATM 6842 O O   . HOH T 7 .   ? -33.596 -34.230 34.681  1.00 27.15 ?  776  HOH A O   1 
HETATM 6843 O O   . HOH T 7 .   ? -18.246 -44.430 32.469  1.00 9.24  ?  777  HOH A O   1 
HETATM 6844 O O   . HOH T 7 .   ? -4.122  -43.116 3.650   1.00 27.99 ?  778  HOH A O   1 
HETATM 6845 O O   . HOH T 7 .   ? -18.209 -53.070 19.708  1.00 11.96 ?  779  HOH A O   1 
HETATM 6846 O O   . HOH T 7 .   ? -16.895 -47.559 54.155  1.00 38.50 ?  780  HOH A O   1 
HETATM 6847 O O   . HOH T 7 .   ? -5.980  -54.450 13.648  1.00 33.81 ?  781  HOH A O   1 
HETATM 6848 O O   . HOH T 7 .   ? -27.221 -23.248 39.291  1.00 24.15 ?  782  HOH A O   1 
HETATM 6849 O O   . HOH T 7 .   ? -29.367 -43.424 60.578  1.00 34.04 ?  783  HOH A O   1 
HETATM 6850 O O   . HOH T 7 .   ? -22.635 -41.599 9.098   1.00 14.20 ?  784  HOH A O   1 
HETATM 6851 O O   . HOH T 7 .   ? -26.443 -41.092 16.671  1.00 16.24 ?  785  HOH A O   1 
HETATM 6852 O O   . HOH T 7 .   ? -5.931  -47.235 41.566  1.00 27.59 ?  786  HOH A O   1 
HETATM 6853 O O   . HOH T 7 .   ? -10.559 -36.968 14.238  1.00 9.17  ?  787  HOH A O   1 
HETATM 6854 O O   . HOH T 7 .   ? -0.030  -50.360 22.524  1.00 35.77 ?  788  HOH A O   1 
HETATM 6855 O O   . HOH T 7 .   ? -33.655 -27.163 41.485  1.00 21.50 ?  789  HOH A O   1 
HETATM 6856 O O   . HOH T 7 .   ? -0.839  -47.859 20.963  1.00 18.36 ?  790  HOH A O   1 
HETATM 6857 O O   . HOH T 7 .   ? -14.865 -38.240 16.755  1.00 8.57  ?  791  HOH A O   1 
HETATM 6858 O O   . HOH T 7 .   ? -5.081  -45.325 43.128  1.00 26.85 ?  792  HOH A O   1 
HETATM 6859 O O   . HOH T 7 .   ? -18.829 -24.480 57.577  1.00 28.07 ?  793  HOH A O   1 
HETATM 6860 O O   . HOH T 7 .   ? -3.150  -50.794 21.458  1.00 20.15 ?  794  HOH A O   1 
HETATM 6861 O O   . HOH T 7 .   ? -21.150 -40.089 7.351   1.00 24.38 ?  795  HOH A O   1 
HETATM 6862 O O   . HOH T 7 .   ? -31.573 -16.080 43.996  1.00 34.31 ?  796  HOH A O   1 
HETATM 6863 O O   . HOH T 7 .   ? -8.714  -57.386 32.455  1.00 11.94 ?  797  HOH A O   1 
HETATM 6864 O O   . HOH T 7 .   ? -9.774  -56.820 12.993  1.00 24.73 ?  798  HOH A O   1 
HETATM 6865 O O   . HOH T 7 .   ? -16.149 -49.402 49.795  1.00 21.03 ?  799  HOH A O   1 
HETATM 6866 O O   . HOH T 7 .   ? -33.757 -44.066 57.057  1.00 31.43 ?  800  HOH A O   1 
HETATM 6867 O O   . HOH T 7 .   ? -27.532 -41.584 59.798  1.00 22.94 ?  801  HOH A O   1 
HETATM 6868 O O   . HOH T 7 .   ? -25.365 -20.455 44.374  1.00 22.48 ?  802  HOH A O   1 
HETATM 6869 O O   . HOH T 7 .   ? -32.537 -47.487 44.035  1.00 27.62 ?  803  HOH A O   1 
HETATM 6870 O O   . HOH T 7 .   ? -10.593 -46.822 26.445  1.00 16.12 ?  804  HOH A O   1 
HETATM 6871 O O   . HOH T 7 .   ? -19.955 -60.917 25.769  1.00 18.40 ?  805  HOH A O   1 
HETATM 6872 O O   . HOH T 7 .   ? -14.315 -39.568 35.960  1.00 8.53  ?  806  HOH A O   1 
HETATM 6873 O O   . HOH T 7 .   ? -33.751 -18.236 47.356  1.00 39.84 ?  807  HOH A O   1 
HETATM 6874 O O   . HOH T 7 .   ? -8.566  -36.355 -0.217  1.00 22.18 ?  808  HOH A O   1 
HETATM 6875 O O   . HOH T 7 .   ? -32.473 -39.360 34.942  1.00 14.84 ?  809  HOH A O   1 
HETATM 6876 O O   . HOH T 7 .   ? -1.354  -55.783 36.588  1.00 31.40 ?  810  HOH A O   1 
HETATM 6877 O O   . HOH T 7 .   ? -28.593 -46.583 32.449  1.00 11.83 ?  811  HOH A O   1 
HETATM 6878 O O   . HOH T 7 .   ? -27.375 -50.166 25.639  1.00 10.36 ?  812  HOH A O   1 
HETATM 6879 O O   . HOH T 7 .   ? -19.289 -35.900 23.684  1.00 10.81 ?  813  HOH A O   1 
HETATM 6880 O O   . HOH T 7 .   ? -18.480 -25.452 49.933  1.00 16.70 ?  814  HOH A O   1 
HETATM 6881 O O   . HOH T 7 .   ? -15.113 -34.390 19.498  1.00 11.36 ?  815  HOH A O   1 
HETATM 6882 O O   . HOH T 7 .   ? -27.696 -27.258 43.568  1.00 14.90 ?  816  HOH A O   1 
HETATM 6883 O O   . HOH T 7 .   ? -19.933 -57.970 32.319  1.00 20.92 ?  817  HOH A O   1 
HETATM 6884 O O   . HOH T 7 .   ? -17.544 -55.820 19.022  1.00 17.25 ?  818  HOH A O   1 
HETATM 6885 O O   . HOH T 7 .   ? -21.144 -28.254 45.948  1.00 22.73 ?  819  HOH A O   1 
HETATM 6886 O O   . HOH T 7 .   ? -31.294 -27.915 40.430  1.00 17.13 ?  820  HOH A O   1 
HETATM 6887 O O   . HOH T 7 .   ? -29.665 -37.315 55.912  1.00 18.23 ?  821  HOH A O   1 
HETATM 6888 O O   . HOH T 7 .   ? -10.785 -42.508 2.196   1.00 28.65 ?  822  HOH A O   1 
HETATM 6889 O O   . HOH T 7 .   ? -21.028 -51.158 39.190  1.00 15.33 ?  823  HOH A O   1 
HETATM 6890 O O   . HOH T 7 .   ? -28.200 -47.048 48.701  1.00 16.83 ?  824  HOH A O   1 
HETATM 6891 O O   . HOH T 7 .   ? -34.779 -37.436 32.489  1.00 32.13 ?  825  HOH A O   1 
HETATM 6892 O O   . HOH T 7 .   ? -7.510  -39.357 1.716   1.00 24.00 ?  826  HOH A O   1 
HETATM 6893 O O   . HOH T 7 .   ? -20.904 -46.421 54.486  1.00 26.17 ?  827  HOH A O   1 
HETATM 6894 O O   . HOH T 7 .   ? -7.556  -30.456 39.411  1.00 14.52 ?  828  HOH A O   1 
HETATM 6895 O O   . HOH T 7 .   ? -6.424  -45.849 10.824  1.00 8.15  ?  829  HOH A O   1 
HETATM 6896 O O   . HOH T 7 .   ? -15.978 -57.726 26.857  1.00 11.46 ?  830  HOH A O   1 
HETATM 6897 O O   . HOH T 7 .   ? -26.864 -51.358 13.832  1.00 29.29 ?  831  HOH A O   1 
HETATM 6898 O O   . HOH T 7 .   ? -28.234 -17.185 45.083  1.00 32.41 ?  832  HOH A O   1 
HETATM 6899 O O   . HOH T 7 .   ? -20.803 -49.674 36.940  1.00 15.80 ?  833  HOH A O   1 
HETATM 6900 O O   . HOH T 7 .   ? -21.519 -35.320 25.385  1.00 13.61 ?  834  HOH A O   1 
HETATM 6901 O O   . HOH T 7 .   ? -3.159  -55.461 28.755  1.00 28.13 ?  835  HOH A O   1 
HETATM 6902 O O   . HOH T 7 .   ? -22.107 -41.021 46.396  1.00 11.03 ?  836  HOH A O   1 
HETATM 6903 O O   . HOH T 7 .   ? -3.792  -35.214 44.676  1.00 17.50 ?  837  HOH A O   1 
HETATM 6904 O O   . HOH T 7 .   ? -32.509 -47.244 54.607  1.00 31.92 ?  838  HOH A O   1 
HETATM 6905 O O   . HOH T 7 .   ? -18.100 -26.812 36.398  1.00 11.56 ?  839  HOH A O   1 
HETATM 6906 O O   . HOH T 7 .   ? -4.382  -54.119 19.046  1.00 30.50 ?  840  HOH A O   1 
HETATM 6907 O O   . HOH T 7 .   ? -18.619 -55.530 39.993  1.00 26.62 ?  841  HOH A O   1 
HETATM 6908 O O   . HOH T 7 .   ? 0.954   -48.639 37.178  1.00 29.01 ?  842  HOH A O   1 
HETATM 6909 O O   . HOH T 7 .   ? -1.647  -30.138 54.965  1.00 42.90 ?  843  HOH A O   1 
HETATM 6910 O O   . HOH T 7 .   ? -23.945 -40.803 15.491  1.00 14.38 ?  844  HOH A O   1 
HETATM 6911 O O   . HOH T 7 .   ? -23.089 -27.993 34.112  1.00 13.09 ?  845  HOH A O   1 
HETATM 6912 O O   . HOH T 7 .   ? -5.609  -45.725 25.673  1.00 18.98 ?  846  HOH A O   1 
HETATM 6913 O O   . HOH T 7 .   ? -2.590  -46.727 17.477  1.00 22.08 ?  847  HOH A O   1 
HETATM 6914 O O   . HOH T 7 .   ? -28.950 -46.953 16.340  1.00 19.46 ?  848  HOH A O   1 
HETATM 6915 O O   . HOH T 7 .   ? -9.868  -35.155 53.033  1.00 15.25 ?  849  HOH A O   1 
HETATM 6916 O O   . HOH T 7 .   ? -30.867 -34.080 56.821  1.00 21.09 ?  850  HOH A O   1 
HETATM 6917 O O   . HOH T 7 .   ? -11.084 -61.712 39.190  1.00 19.43 ?  851  HOH A O   1 
HETATM 6918 O O   . HOH T 7 .   ? -31.484 -40.943 61.060  1.00 37.20 ?  852  HOH A O   1 
HETATM 6919 O O   . HOH T 7 .   ? -31.494 -50.957 32.641  1.00 18.79 ?  853  HOH A O   1 
HETATM 6920 O O   . HOH T 7 .   ? -31.975 -30.745 40.597  1.00 19.84 ?  854  HOH A O   1 
HETATM 6921 O O   . HOH T 7 .   ? -21.490 -25.418 34.500  1.00 17.05 ?  855  HOH A O   1 
HETATM 6922 O O   . HOH T 7 .   ? -0.207  -40.721 15.305  1.00 30.16 ?  856  HOH A O   1 
HETATM 6923 O O   . HOH T 7 .   ? -14.601 -43.021 45.162  1.00 11.22 ?  857  HOH A O   1 
HETATM 6924 O O   . HOH T 7 .   ? -5.841  -47.579 3.987   1.00 22.84 ?  858  HOH A O   1 
HETATM 6925 O O   . HOH T 7 .   ? -11.524 -23.056 47.227  1.00 31.36 ?  859  HOH A O   1 
HETATM 6926 O O   . HOH T 7 .   ? -7.987  -38.017 14.176  1.00 20.77 ?  860  HOH A O   1 
HETATM 6927 O O   . HOH T 7 .   ? -5.047  -61.185 23.007  1.00 32.02 ?  861  HOH A O   1 
HETATM 6928 O O   . HOH T 7 .   ? -10.417 -64.966 27.273  1.00 31.13 ?  862  HOH A O   1 
HETATM 6929 O O   . HOH T 7 .   ? -13.382 -46.003 47.170  1.00 13.01 ?  863  HOH A O   1 
HETATM 6930 O O   . HOH T 7 .   ? -8.850  -32.407 49.236  1.00 13.42 ?  864  HOH A O   1 
HETATM 6931 O O   . HOH T 7 .   ? -5.759  -29.537 4.387   1.00 10.61 ?  865  HOH A O   1 
HETATM 6932 O O   . HOH T 7 .   ? -15.264 -29.969 35.076  1.00 8.90  ?  866  HOH A O   1 
HETATM 6933 O O   . HOH T 7 .   ? -15.818 -56.499 3.255   1.00 29.12 ?  867  HOH A O   1 
HETATM 6934 O O   . HOH T 7 .   ? -13.261 -39.786 2.602   1.00 20.10 ?  868  HOH A O   1 
HETATM 6935 O O   . HOH T 7 .   ? -21.506 -54.786 9.739   1.00 24.19 ?  869  HOH A O   1 
HETATM 6936 O O   . HOH T 7 .   ? -7.685  -52.437 43.378  1.00 31.41 ?  870  HOH A O   1 
HETATM 6937 O O   . HOH T 7 .   ? -9.844  -30.476 57.450  1.00 20.69 ?  871  HOH A O   1 
HETATM 6938 O O   . HOH T 7 .   ? -18.590 -42.375 40.509  1.00 8.52  ?  872  HOH A O   1 
HETATM 6939 O O   . HOH T 7 .   ? -30.150 -47.691 36.983  1.00 18.48 ?  873  HOH A O   1 
HETATM 6940 O O   . HOH T 7 .   ? -22.305 -52.557 46.230  1.00 18.62 ?  874  HOH A O   1 
HETATM 6941 O O   . HOH T 7 .   ? -20.763 -38.831 66.875  1.00 35.25 ?  875  HOH A O   1 
HETATM 6942 O O   . HOH T 7 .   ? -1.616  -33.224 8.742   1.00 23.85 ?  876  HOH A O   1 
HETATM 6943 O O   . HOH T 7 .   ? -42.378 -58.867 26.508  1.00 33.90 ?  877  HOH A O   1 
HETATM 6944 O O   . HOH T 7 .   ? -7.755  -44.256 23.256  1.00 12.36 ?  878  HOH A O   1 
HETATM 6945 O O   . HOH T 7 .   ? -12.049 -61.198 23.405  1.00 31.07 ?  879  HOH A O   1 
HETATM 6946 O O   . HOH T 7 .   ? -31.566 -52.504 46.257  1.00 30.42 ?  880  HOH A O   1 
HETATM 6947 O O   . HOH T 7 .   ? -33.709 -20.632 45.681  1.00 32.72 ?  881  HOH A O   1 
HETATM 6948 O O   . HOH T 7 .   ? -32.109 -32.653 42.912  1.00 16.72 ?  882  HOH A O   1 
HETATM 6949 O O   . HOH T 7 .   ? -39.817 -54.283 25.200  1.00 18.16 ?  883  HOH A O   1 
HETATM 6950 O O   . HOH T 7 .   ? -4.030  -39.968 42.221  1.00 21.73 ?  884  HOH A O   1 
HETATM 6951 O O   . HOH T 7 .   ? -4.861  -44.424 30.409  1.00 17.06 ?  885  HOH A O   1 
HETATM 6952 O O   . HOH T 7 .   ? -8.386  -51.602 6.842   1.00 16.28 ?  886  HOH A O   1 
HETATM 6953 O O   . HOH T 7 .   ? -14.895 -58.389 16.474  1.00 33.47 ?  887  HOH A O   1 
HETATM 6954 O O   . HOH T 7 .   ? -34.799 -21.174 52.120  1.00 32.66 ?  888  HOH A O   1 
HETATM 6955 O O   . HOH T 7 .   ? -18.351 -37.172 65.876  1.00 29.53 ?  889  HOH A O   1 
HETATM 6956 O O   . HOH T 7 .   ? -28.975 -48.809 33.809  1.00 13.32 ?  890  HOH A O   1 
HETATM 6957 O O   . HOH T 7 .   ? -13.567 -28.145 40.928  1.00 22.52 ?  891  HOH A O   1 
HETATM 6958 O O   . HOH T 7 .   ? -11.365 -57.856 40.179  1.00 25.61 ?  892  HOH A O   1 
HETATM 6959 O O   . HOH T 7 .   ? -19.775 -57.248 35.744  1.00 25.60 ?  893  HOH A O   1 
HETATM 6960 O O   . HOH T 7 .   ? -8.140  -48.574 41.661  1.00 17.57 ?  894  HOH A O   1 
HETATM 6961 O O   . HOH T 7 .   ? -29.121 -49.834 50.230  1.00 30.35 ?  895  HOH A O   1 
HETATM 6962 O O   . HOH T 7 .   ? -10.638 -30.343 49.740  1.00 14.26 ?  896  HOH A O   1 
HETATM 6963 O O   . HOH T 7 .   ? -28.733 -26.901 40.932  1.00 14.17 ?  897  HOH A O   1 
HETATM 6964 O O   . HOH T 7 .   ? -39.678 -33.186 48.405  1.00 33.35 ?  898  HOH A O   1 
HETATM 6965 O O   . HOH T 7 .   ? -36.933 -42.415 55.223  1.00 28.92 ?  899  HOH A O   1 
HETATM 6966 O O   . HOH T 7 .   ? -16.966 -26.718 51.975  1.00 14.02 ?  900  HOH A O   1 
HETATM 6967 O O   . HOH T 7 .   ? -24.722 -54.637 39.708  1.00 16.64 ?  901  HOH A O   1 
HETATM 6968 O O   . HOH T 7 .   ? -10.942 -58.947 8.813   1.00 30.11 ?  902  HOH A O   1 
HETATM 6969 O O   . HOH T 7 .   ? -40.429 -39.918 46.998  1.00 34.83 ?  903  HOH A O   1 
HETATM 6970 O O   . HOH T 7 .   ? -13.597 -56.004 43.464  1.00 28.39 ?  904  HOH A O   1 
HETATM 6971 O O   . HOH T 7 .   ? -15.710 -37.082 4.029   1.00 21.18 ?  905  HOH A O   1 
HETATM 6972 O O   . HOH T 7 .   ? -15.198 -54.515 46.184  1.00 20.04 ?  906  HOH A O   1 
HETATM 6973 O O   . HOH T 7 .   ? -6.299  -56.644 40.894  1.00 20.79 ?  907  HOH A O   1 
HETATM 6974 O O   . HOH T 7 .   ? -4.361  -42.205 27.615  1.00 29.39 ?  908  HOH A O   1 
HETATM 6975 O O   . HOH T 7 .   ? -39.391 -38.916 44.415  1.00 29.05 ?  909  HOH A O   1 
HETATM 6976 O O   . HOH T 7 .   ? -13.791 -30.837 61.895  1.00 28.27 ?  910  HOH A O   1 
HETATM 6977 O O   . HOH T 7 .   ? -34.565 -43.758 31.130  1.00 13.68 ?  911  HOH A O   1 
HETATM 6978 O O   . HOH T 7 .   ? -35.299 -34.057 41.379  1.00 26.24 ?  912  HOH A O   1 
HETATM 6979 O O   . HOH T 7 .   ? -35.230 -29.809 42.554  1.00 21.82 ?  913  HOH A O   1 
HETATM 6980 O O   . HOH T 7 .   ? -1.192  -45.694 27.878  1.00 21.52 ?  914  HOH A O   1 
HETATM 6981 O O   . HOH T 7 .   ? -10.614 -39.053 63.883  1.00 36.36 ?  915  HOH A O   1 
HETATM 6982 O O   . HOH T 7 .   ? -15.626 -57.055 37.656  1.00 19.46 ?  916  HOH A O   1 
HETATM 6983 O O   . HOH T 7 .   ? -21.991 -58.793 28.282  1.00 17.65 ?  917  HOH A O   1 
HETATM 6984 O O   . HOH T 7 .   ? -12.835 -60.324 37.442  1.00 20.40 ?  918  HOH A O   1 
HETATM 6985 O O   . HOH T 7 .   ? -30.808 -23.856 58.760  1.00 35.28 ?  919  HOH A O   1 
HETATM 6986 O O   . HOH T 7 .   ? -25.766 -21.077 38.167  1.00 34.23 ?  920  HOH A O   1 
HETATM 6987 O O   . HOH T 7 .   ? -33.413 -32.831 55.973  1.00 28.10 ?  921  HOH A O   1 
HETATM 6988 O O   . HOH T 7 .   ? -8.351  -41.246 23.866  1.00 18.76 ?  922  HOH A O   1 
HETATM 6989 O O   . HOH T 7 .   ? -27.407 -52.041 36.141  1.00 14.59 ?  923  HOH A O   1 
HETATM 6990 O O   . HOH T 7 .   ? -9.651  -55.589 41.325  1.00 19.03 ?  924  HOH A O   1 
HETATM 6991 O O   . HOH T 7 .   ? -41.819 -51.848 28.872  1.00 26.41 ?  925  HOH A O   1 
HETATM 6992 O O   . HOH T 7 .   ? -24.410 -50.959 10.210  1.00 34.98 ?  926  HOH A O   1 
HETATM 6993 O O   . HOH T 7 .   ? -17.239 -62.874 30.062  1.00 22.11 ?  927  HOH A O   1 
HETATM 6994 O O   . HOH T 7 .   ? -16.111 -25.594 54.287  1.00 26.53 ?  928  HOH A O   1 
HETATM 6995 O O   . HOH T 7 .   ? -14.784 -24.158 49.317  1.00 23.15 ?  929  HOH A O   1 
HETATM 6996 O O   . HOH T 7 .   ? -20.491 -54.715 38.278  1.00 21.86 ?  930  HOH A O   1 
HETATM 6997 O O   . HOH T 7 .   ? 0.682   -41.092 6.165   1.00 17.96 ?  931  HOH A O   1 
HETATM 6998 O O   . HOH T 7 .   ? -14.092 -61.260 9.222   1.00 37.04 ?  932  HOH A O   1 
HETATM 6999 O O   . HOH T 7 .   ? -12.534 -40.564 34.184  1.00 8.01  ?  933  HOH A O   1 
HETATM 7000 O O   . HOH T 7 .   ? -13.829 -27.591 38.458  1.00 13.89 ?  934  HOH A O   1 
HETATM 7001 O O   . HOH T 7 .   ? -17.654 -60.038 9.380   1.00 33.84 ?  935  HOH A O   1 
HETATM 7002 O O   . HOH T 7 .   ? -18.643 -48.999 51.243  1.00 21.21 ?  936  HOH A O   1 
HETATM 7003 O O   . HOH T 7 .   ? -20.773 -43.763 59.029  1.00 32.59 ?  937  HOH A O   1 
HETATM 7004 O O   . HOH T 7 .   ? -7.625  -40.505 29.348  1.00 27.20 ?  938  HOH A O   1 
HETATM 7005 O O   . HOH T 7 .   ? -8.992  -49.192 7.861   1.00 17.68 ?  939  HOH A O   1 
HETATM 7006 O O   . HOH T 7 .   ? -39.402 -46.503 46.983  1.00 27.62 ?  940  HOH A O   1 
HETATM 7007 O O   . HOH T 7 .   ? -31.193 -49.829 56.935  1.00 41.90 ?  941  HOH A O   1 
HETATM 7008 O O   . HOH T 7 .   ? -17.960 -55.523 3.728   1.00 34.10 ?  942  HOH A O   1 
HETATM 7009 O O   . HOH T 7 .   ? -17.730 -57.593 13.725  1.00 33.18 ?  943  HOH A O   1 
HETATM 7010 O O   . HOH T 7 .   ? -22.224 -42.275 5.421   1.00 30.27 ?  944  HOH A O   1 
HETATM 7011 O O   . HOH T 7 .   ? -21.010 -44.495 4.421   1.00 29.14 ?  945  HOH A O   1 
HETATM 7012 O O   . HOH T 7 .   ? -3.416  -33.998 59.464  1.00 43.47 ?  946  HOH A O   1 
HETATM 7013 O O   . HOH T 7 .   ? -30.016 -58.382 32.919  1.00 27.96 ?  947  HOH A O   1 
HETATM 7014 O O   . HOH T 7 .   ? -20.021 -48.541 2.558   1.00 29.82 ?  948  HOH A O   1 
HETATM 7015 O O   . HOH T 7 .   ? -33.231 -45.755 39.686  1.00 29.30 ?  949  HOH A O   1 
HETATM 7016 O O   . HOH T 7 .   ? -0.057  -38.500 15.709  1.00 34.59 ?  950  HOH A O   1 
HETATM 7017 O O   . HOH T 7 .   ? -35.370 -43.936 39.365  1.00 28.69 ?  951  HOH A O   1 
HETATM 7018 O O   . HOH T 7 .   ? -4.846  -51.943 42.578  1.00 34.65 ?  952  HOH A O   1 
HETATM 7019 O O   . HOH T 7 .   ? -34.484 -23.591 50.180  1.00 27.25 ?  953  HOH A O   1 
HETATM 7020 O O   . HOH T 7 .   ? -17.555 -38.137 5.836   1.00 17.97 ?  954  HOH A O   1 
HETATM 7021 O O   . HOH T 7 .   ? -39.323 -48.732 32.518  1.00 37.61 ?  955  HOH A O   1 
HETATM 7022 O O   . HOH T 7 .   ? -34.968 -50.777 34.189  1.00 33.97 ?  956  HOH A O   1 
HETATM 7023 O O   . HOH T 7 .   ? -18.711 -52.767 49.900  1.00 32.80 ?  957  HOH A O   1 
HETATM 7024 O O   . HOH T 7 .   ? -1.952  -39.737 27.100  1.00 22.98 ?  958  HOH A O   1 
HETATM 7025 O O   . HOH T 7 .   ? -16.678 -35.892 24.549  1.00 16.45 ?  959  HOH A O   1 
HETATM 7026 O O   . HOH T 7 .   ? -28.718 -30.325 59.711  1.00 32.01 ?  960  HOH A O   1 
HETATM 7027 O O   . HOH T 7 .   ? -11.762 -51.054 3.587   1.00 30.32 ?  961  HOH A O   1 
HETATM 7028 O O   . HOH T 7 .   ? -2.032  -54.838 34.439  1.00 28.38 ?  962  HOH A O   1 
HETATM 7029 O O   . HOH T 7 .   ? -32.528 -31.653 32.829  1.00 37.89 ?  963  HOH A O   1 
HETATM 7030 O O   . HOH T 7 .   ? -21.156 -39.086 10.799  1.00 18.80 ?  964  HOH A O   1 
HETATM 7031 O O   . HOH T 7 .   ? -33.014 -24.933 52.287  1.00 36.31 ?  965  HOH A O   1 
HETATM 7032 O O   . HOH T 7 .   ? -36.381 -26.878 47.997  1.00 38.95 ?  966  HOH A O   1 
HETATM 7033 O O   . HOH T 7 .   ? -26.640 -51.572 50.144  1.00 35.17 ?  967  HOH A O   1 
HETATM 7034 O O   . HOH T 7 .   ? -8.921  -30.489 36.900  1.00 11.84 ?  968  HOH A O   1 
HETATM 7035 O O   . HOH T 7 .   ? -5.484  -39.020 0.212   1.00 33.00 ?  969  HOH A O   1 
HETATM 7036 O O   . HOH T 7 .   ? -37.625 -36.234 52.008  1.00 34.37 ?  970  HOH A O   1 
HETATM 7037 O O   . HOH T 7 .   ? -16.257 -25.211 58.536  1.00 39.74 ?  971  HOH A O   1 
HETATM 7038 O O   . HOH T 7 .   ? -8.359  -49.094 44.231  1.00 28.46 ?  972  HOH A O   1 
HETATM 7039 O O   . HOH T 7 .   ? -7.860  -27.276 39.739  1.00 24.15 ?  973  HOH A O   1 
HETATM 7040 O O   . HOH T 7 .   ? -10.680 -28.076 40.386  1.00 26.67 ?  974  HOH A O   1 
HETATM 7041 O O   . HOH T 7 .   ? -3.178  -36.642 11.585  1.00 24.30 ?  975  HOH A O   1 
HETATM 7042 O O   . HOH T 7 .   ? -27.618 -27.955 60.410  1.00 34.14 ?  976  HOH A O   1 
HETATM 7043 O O   . HOH T 7 .   ? -19.339 -51.611 52.287  1.00 32.33 ?  977  HOH A O   1 
HETATM 7044 O O   . HOH T 7 .   ? -0.318  -46.987 18.477  1.00 30.96 ?  978  HOH A O   1 
HETATM 7045 O O   . HOH T 7 .   ? -5.218  -35.854 13.228  1.00 29.43 ?  979  HOH A O   1 
HETATM 7046 O O   . HOH T 7 .   ? -3.975  -44.786 27.669  1.00 21.96 ?  980  HOH A O   1 
HETATM 7047 O O   . HOH T 7 .   ? -36.871 -43.318 29.568  1.00 16.05 ?  981  HOH A O   1 
HETATM 7048 O O   . HOH T 7 .   ? -29.720 -50.112 35.785  1.00 28.62 ?  982  HOH A O   1 
HETATM 7049 O O   . HOH T 7 .   ? -9.691  -43.849 51.262  1.00 23.08 ?  983  HOH A O   1 
HETATM 7050 O O   . HOH T 7 .   ? -14.935 -51.824 50.709  1.00 37.90 ?  984  HOH A O   1 
HETATM 7051 O O   . HOH T 7 .   ? 3.475   -39.396 12.036  1.00 23.20 ?  985  HOH A O   1 
HETATM 7052 O O   . HOH T 7 .   ? -0.729  -28.600 44.908  1.00 42.03 ?  986  HOH A O   1 
HETATM 7053 O O   . HOH T 7 .   ? -13.348 -39.504 64.712  1.00 38.45 ?  987  HOH A O   1 
HETATM 7054 O O   . HOH T 7 .   ? -19.607 -58.313 29.615  1.00 15.27 ?  988  HOH A O   1 
HETATM 7055 O O   . HOH T 7 .   ? -34.370 -31.307 40.592  1.00 27.33 ?  989  HOH A O   1 
HETATM 7056 O O   . HOH T 7 .   ? -19.695 -39.186 4.779   1.00 37.73 ?  990  HOH A O   1 
HETATM 7057 O O   . HOH T 7 .   ? -22.080 -56.909 38.270  1.00 28.88 ?  991  HOH A O   1 
HETATM 7058 O O   . HOH T 7 .   ? -24.500 -53.636 9.545   1.00 38.12 ?  992  HOH A O   1 
HETATM 7059 O O   . HOH T 7 .   ? -35.313 -14.939 57.822  1.00 40.76 ?  993  HOH A O   1 
HETATM 7060 O O   . HOH T 7 .   ? -31.917 -51.723 35.578  1.00 32.19 ?  994  HOH A O   1 
HETATM 7061 O O   . HOH T 7 .   ? -23.796 -39.349 12.914  1.00 11.39 ?  995  HOH A O   1 
HETATM 7062 O O   . HOH T 7 .   ? -24.886 -40.497 10.443  1.00 20.88 ?  996  HOH A O   1 
HETATM 7063 O O   . HOH T 7 .   ? -27.285 -54.186 38.061  1.00 26.53 ?  997  HOH A O   1 
HETATM 7064 O O   . HOH T 7 .   ? -11.924 -48.372 50.357  1.00 28.74 ?  998  HOH A O   1 
HETATM 7065 O O   . HOH T 7 .   ? -8.398  -45.201 25.604  1.00 17.27 ?  999  HOH A O   1 
HETATM 7066 O O   . HOH T 7 .   ? -2.630  -58.326 36.858  1.00 33.03 ?  1000 HOH A O   1 
HETATM 7067 O O   . HOH T 7 .   ? -21.459 -53.219 52.846  1.00 39.89 ?  1001 HOH A O   1 
HETATM 7068 O O   . HOH T 7 .   ? -3.601  -28.026 3.653   1.00 19.26 ?  1002 HOH A O   1 
HETATM 7069 O O   . HOH T 7 .   ? -22.871 -20.809 44.175  1.00 33.97 ?  1003 HOH A O   1 
HETATM 7070 O O   . HOH T 7 .   ? -35.757 -39.733 32.309  1.00 33.78 ?  1004 HOH A O   1 
HETATM 7071 O O   . HOH T 7 .   ? -2.774  -30.209 6.995   1.00 35.06 ?  1005 HOH A O   1 
HETATM 7072 O O   . HOH T 7 .   ? -41.130 -34.842 46.956  1.00 33.50 ?  1006 HOH A O   1 
HETATM 7073 O O   . HOH T 7 .   ? -9.805  -45.116 53.612  1.00 32.47 ?  1007 HOH A O   1 
HETATM 7074 O O   . HOH T 7 .   ? -6.900  -59.284 40.934  1.00 30.01 ?  1008 HOH A O   1 
HETATM 7075 O O   . HOH T 7 .   ? -35.282 -26.253 39.941  1.00 34.35 ?  1009 HOH A O   1 
HETATM 7076 O O   . HOH T 7 .   ? -2.820  -34.158 10.492  1.00 29.24 ?  1010 HOH A O   1 
HETATM 7077 O O   . HOH T 7 .   ? -8.560  -38.062 -2.271  1.00 28.95 ?  1011 HOH A O   1 
HETATM 7078 O O   . HOH T 7 .   ? -18.146 -23.202 51.431  1.00 25.44 ?  1012 HOH A O   1 
HETATM 7079 O O   . HOH T 7 .   ? -10.824 -47.018 48.144  1.00 20.58 ?  1013 HOH A O   1 
HETATM 7080 O O   . HOH T 7 .   ? -14.103 -58.399 39.447  1.00 28.26 ?  1014 HOH A O   1 
HETATM 7081 O O   . HOH T 7 .   ? -3.007  -60.461 24.814  1.00 34.68 ?  1015 HOH A O   1 
HETATM 7082 O O   . HOH T 7 .   ? -12.444 -62.375 41.201  1.00 29.08 ?  1016 HOH A O   1 
HETATM 7083 O O   . HOH T 7 .   ? -9.136  -48.530 46.772  1.00 27.93 ?  1017 HOH A O   1 
HETATM 7084 O O   . HOH T 7 .   ? -21.115 -54.744 47.211  1.00 31.24 ?  1018 HOH A O   1 
HETATM 7085 O O   . HOH T 7 .   ? -4.919  -46.327 45.611  1.00 34.24 ?  1019 HOH A O   1 
HETATM 7086 O O   . HOH T 7 .   ? -5.771  -52.448 6.883   1.00 29.20 ?  1020 HOH A O   1 
HETATM 7087 O O   . HOH T 7 .   ? -9.358  -51.109 47.842  1.00 36.88 ?  1021 HOH A O   1 
HETATM 7088 O O   . HOH T 7 .   ? -8.849  -45.594 49.395  1.00 23.64 ?  1022 HOH A O   1 
HETATM 7089 O O   . HOH U 7 .   ? -15.992 -66.263 14.016  1.00 37.55 ?  201  HOH C O   1 
HETATM 7090 O O   . HOH U 7 .   ? -43.917 -72.120 15.092  1.00 34.10 ?  202  HOH C O   1 
HETATM 7091 O O   . HOH U 7 .   ? -36.559 -50.950 20.717  1.00 19.81 ?  203  HOH C O   1 
HETATM 7092 O O   . HOH U 7 .   ? -30.822 -78.729 12.840  1.00 43.00 ?  204  HOH C O   1 
HETATM 7093 O O   . HOH U 7 .   ? -24.660 -62.070 34.767  1.00 42.70 ?  205  HOH C O   1 
HETATM 7094 O O   . HOH U 7 .   ? -32.762 -52.751 10.021  1.00 26.83 ?  206  HOH C O   1 
HETATM 7095 O O   . HOH U 7 .   ? -27.561 -60.022 13.562  1.00 15.06 ?  207  HOH C O   1 
HETATM 7096 O O   . HOH U 7 .   ? -29.523 -55.107 7.788   1.00 34.04 ?  208  HOH C O   1 
HETATM 7097 O O   . HOH U 7 .   ? -11.340 -59.335 13.811  1.00 35.14 ?  209  HOH C O   1 
HETATM 7098 O O   . HOH U 7 .   ? -21.256 -59.582 14.968  1.00 27.16 ?  210  HOH C O   1 
HETATM 7099 O O   . HOH U 7 .   ? -32.778 -72.375 30.918  1.00 38.75 ?  211  HOH C O   1 
HETATM 7100 O O   . HOH U 7 .   ? -27.880 -68.801 7.866   1.00 28.67 ?  212  HOH C O   1 
HETATM 7101 O O   . HOH U 7 .   ? -22.411 -54.981 12.370  1.00 17.69 ?  213  HOH C O   1 
HETATM 7102 O O   . HOH U 7 .   ? -35.339 -76.863 15.309  1.00 36.48 ?  214  HOH C O   1 
HETATM 7103 O O   . HOH U 7 .   ? -37.888 -74.771 20.761  1.00 28.47 ?  215  HOH C O   1 
HETATM 7104 O O   . HOH U 7 .   ? -26.713 -55.604 19.180  1.00 16.16 ?  216  HOH C O   1 
HETATM 7105 O O   . HOH U 7 .   ? -41.275 -72.599 22.254  1.00 32.03 ?  217  HOH C O   1 
HETATM 7106 O O   . HOH U 7 .   ? -57.297 -50.299 0.219   1.00 34.64 ?  218  HOH C O   1 
HETATM 7107 O O   . HOH U 7 .   ? -37.693 -73.413 15.433  1.00 25.17 ?  219  HOH C O   1 
HETATM 7108 O O   . HOH U 7 .   ? -46.463 -56.125 3.568   1.00 42.72 ?  220  HOH C O   1 
HETATM 7109 O O   . HOH U 7 .   ? -19.768 -67.917 24.766  1.00 34.29 ?  221  HOH C O   1 
HETATM 7110 O O   . HOH U 7 .   ? -46.647 -64.158 22.531  1.00 35.08 ?  222  HOH C O   1 
HETATM 7111 O O   . HOH U 7 .   ? -44.924 -68.969 20.184  1.00 33.69 ?  223  HOH C O   1 
HETATM 7112 O O   . HOH U 7 .   ? -40.207 -75.582 8.436   1.00 33.41 ?  224  HOH C O   1 
HETATM 7113 O O   . HOH U 7 .   ? -26.594 -54.879 10.026  1.00 24.61 ?  225  HOH C O   1 
HETATM 7114 O O   . HOH U 7 .   ? -21.426 -67.560 11.438  1.00 35.22 ?  226  HOH C O   1 
HETATM 7115 O O   . HOH U 7 .   ? -24.288 -61.253 8.333   1.00 28.12 ?  227  HOH C O   1 
HETATM 7116 O O   . HOH U 7 .   ? -30.063 -76.956 25.741  1.00 37.92 ?  228  HOH C O   1 
HETATM 7117 O O   . HOH U 7 .   ? -39.617 -52.531 13.508  1.00 20.95 ?  229  HOH C O   1 
HETATM 7118 O O   . HOH U 7 .   ? -36.643 -64.444 30.658  1.00 30.55 ?  230  HOH C O   1 
HETATM 7119 O O   . HOH U 7 .   ? -38.012 -69.891 4.812   1.00 25.29 ?  231  HOH C O   1 
HETATM 7120 O O   . HOH U 7 .   ? -31.285 -63.600 3.434   1.00 32.46 ?  232  HOH C O   1 
HETATM 7121 O O   . HOH U 7 .   ? -41.856 -54.193 13.615  1.00 27.73 ?  233  HOH C O   1 
HETATM 7122 O O   . HOH U 7 .   ? -31.280 -59.084 30.822  1.00 18.98 ?  234  HOH C O   1 
HETATM 7123 O O   . HOH U 7 .   ? -28.383 -53.335 11.840  1.00 28.25 ?  235  HOH C O   1 
HETATM 7124 O O   . HOH U 7 .   ? -45.513 -54.655 13.544  1.00 36.00 ?  236  HOH C O   1 
HETATM 7125 O O   . HOH U 7 .   ? -40.717 -56.810 21.804  1.00 20.62 ?  237  HOH C O   1 
HETATM 7126 O O   . HOH U 7 .   ? -38.920 -59.660 0.425   1.00 36.80 ?  238  HOH C O   1 
HETATM 7127 O O   . HOH U 7 .   ? -49.637 -70.254 14.114  1.00 36.39 ?  239  HOH C O   1 
HETATM 7128 O O   . HOH U 7 .   ? -27.633 -62.360 6.201   1.00 25.45 ?  240  HOH C O   1 
HETATM 7129 O O   . HOH U 7 .   ? -25.532 -65.229 25.818  1.00 24.08 ?  241  HOH C O   1 
HETATM 7130 O O   . HOH U 7 .   ? -49.766 -60.284 16.514  1.00 41.98 ?  242  HOH C O   1 
HETATM 7131 O O   . HOH U 7 .   ? -32.114 -66.742 2.457   1.00 35.16 ?  243  HOH C O   1 
HETATM 7132 O O   . HOH U 7 .   ? -42.491 -56.108 11.741  1.00 24.78 ?  244  HOH C O   1 
HETATM 7133 O O   . HOH U 7 .   ? -42.287 -54.933 20.626  1.00 32.77 ?  245  HOH C O   1 
HETATM 7134 O O   . HOH U 7 .   ? -46.599 -58.907 14.733  1.00 28.89 ?  246  HOH C O   1 
HETATM 7135 O O   . HOH U 7 .   ? -23.059 -56.824 9.311   1.00 27.42 ?  247  HOH C O   1 
HETATM 7136 O O   . HOH U 7 .   ? -25.327 -54.852 25.037  1.00 18.38 ?  248  HOH C O   1 
HETATM 7137 O O   . HOH U 7 .   ? -48.690 -70.741 8.259   1.00 31.80 ?  249  HOH C O   1 
HETATM 7138 O O   . HOH U 7 .   ? -35.198 -52.192 8.533   1.00 29.91 ?  250  HOH C O   1 
HETATM 7139 O O   . HOH U 7 .   ? -22.767 -54.809 24.023  1.00 14.05 ?  251  HOH C O   1 
HETATM 7140 O O   . HOH U 7 .   ? -38.484 -55.236 22.018  1.00 15.36 ?  252  HOH C O   1 
HETATM 7141 O O   . HOH U 7 .   ? -24.151 -58.521 30.040  1.00 20.81 ?  253  HOH C O   1 
HETATM 7142 O O   . HOH U 7 .   ? -36.586 -53.358 4.660   1.00 30.67 ?  254  HOH C O   1 
HETATM 7143 O O   . HOH U 7 .   ? -46.060 -66.398 21.856  1.00 33.02 ?  255  HOH C O   1 
HETATM 7144 O O   . HOH U 7 .   ? -14.538 -63.807 19.214  1.00 35.85 ?  256  HOH C O   1 
HETATM 7145 O O   . HOH U 7 .   ? -29.091 -78.413 20.382  1.00 44.55 ?  257  HOH C O   1 
HETATM 7146 O O   . HOH U 7 .   ? -43.306 -66.382 26.082  1.00 28.35 ?  258  HOH C O   1 
HETATM 7147 O O   . HOH U 7 .   ? -31.911 -70.917 5.349   1.00 33.78 ?  259  HOH C O   1 
HETATM 7148 O O   . HOH U 7 .   ? -42.315 -70.667 25.850  1.00 37.46 ?  260  HOH C O   1 
HETATM 7149 O O   . HOH U 7 .   ? -43.857 -53.526 8.506   1.00 30.98 ?  261  HOH C O   1 
HETATM 7150 O O   . HOH U 7 .   ? -36.044 -75.589 22.532  1.00 34.91 ?  262  HOH C O   1 
HETATM 7151 O O   . HOH U 7 .   ? -32.739 -60.721 2.704   1.00 34.42 ?  263  HOH C O   1 
HETATM 7152 O O   . HOH U 7 .   ? -44.231 -73.083 19.724  1.00 38.81 ?  264  HOH C O   1 
HETATM 7153 O O   . HOH U 7 .   ? -41.096 -51.195 17.107  1.00 34.08 ?  265  HOH C O   1 
HETATM 7154 O O   . HOH U 7 .   ? -20.501 -63.012 27.319  1.00 31.81 ?  266  HOH C O   1 
HETATM 7155 O O   . HOH U 7 .   ? -39.066 -54.363 5.947   1.00 27.12 ?  267  HOH C O   1 
HETATM 7156 O O   . HOH U 7 .   ? -35.300 -66.775 29.953  1.00 34.80 ?  268  HOH C O   1 
HETATM 7157 O O   . HOH U 7 .   ? -40.387 -44.171 18.176  1.00 21.44 ?  269  HOH C O   1 
HETATM 7158 O O   . HOH U 7 .   ? -22.551 -61.529 31.539  1.00 30.00 ?  270  HOH C O   1 
HETATM 7159 O O   . HOH U 7 .   ? -21.381 -60.596 12.300  1.00 30.46 ?  271  HOH C O   1 
HETATM 7160 O O   . HOH U 7 .   ? -41.514 -48.064 16.480  1.00 28.85 ?  272  HOH C O   1 
HETATM 7161 O O   . HOH U 7 .   ? -16.491 -70.562 16.841  1.00 48.09 ?  273  HOH C O   1 
HETATM 7162 O O   . HOH U 7 .   ? -18.848 -72.807 19.287  1.00 45.96 ?  274  HOH C O   1 
HETATM 7163 O O   . HOH U 7 .   ? -30.590 -57.983 4.561   1.00 31.76 ?  275  HOH C O   1 
HETATM 7164 O O   . HOH U 7 .   ? -46.109 -70.501 2.993   1.00 37.91 ?  276  HOH C O   1 
HETATM 7165 O O   . HOH U 7 .   ? -20.405 -74.831 21.469  1.00 34.48 ?  277  HOH C O   1 
HETATM 7166 O O   . HOH U 7 .   ? -30.047 -71.956 30.669  1.00 34.25 ?  278  HOH C O   1 
HETATM 7167 O O   . HOH U 7 .   ? -34.071 -76.127 20.670  1.00 29.10 ?  279  HOH C O   1 
HETATM 7168 O O   . HOH U 7 .   ? -28.850 -68.888 29.050  1.00 25.13 ?  280  HOH C O   1 
HETATM 7169 O O   . HOH U 7 .   ? -31.967 -77.720 21.508  1.00 39.46 ?  281  HOH C O   1 
HETATM 7170 O O   . HOH U 7 .   ? -28.113 -49.610 15.718  1.00 30.24 ?  282  HOH C O   1 
HETATM 7171 O O   . HOH U 7 .   ? -38.669 -64.998 -1.641  1.00 40.77 ?  283  HOH C O   1 
HETATM 7172 O O   . HOH U 7 .   ? -48.029 -72.541 14.589  1.00 35.35 ?  284  HOH C O   1 
HETATM 7173 O O   . HOH U 7 .   ? -41.850 -73.383 6.881   1.00 34.61 ?  285  HOH C O   1 
HETATM 7174 O O   . HOH U 7 .   ? -39.222 -75.389 14.889  1.00 30.69 ?  286  HOH C O   1 
HETATM 7175 O O   . HOH U 7 .   ? -45.131 -55.055 16.528  1.00 40.52 ?  287  HOH C O   1 
HETATM 7176 O O   . HOH U 7 .   ? -42.108 -61.111 27.188  1.00 36.78 ?  288  HOH C O   1 
HETATM 7177 O O   . HOH U 7 .   ? -42.400 -57.803 24.040  1.00 39.68 ?  289  HOH C O   1 
HETATM 7178 O O   . HOH U 7 .   ? -38.731 -52.543 21.488  1.00 18.53 ?  290  HOH C O   1 
HETATM 7179 O O   . HOH U 7 .   ? -34.894 -49.243 9.474   1.00 35.84 ?  291  HOH C O   1 
HETATM 7180 O O   . HOH U 7 .   ? -41.172 -51.946 20.898  1.00 25.03 ?  292  HOH C O   1 
HETATM 7181 O O   . HOH U 7 .   ? -40.568 -53.354 4.250   1.00 35.24 ?  293  HOH C O   1 
HETATM 7182 O O   . HOH U 7 .   ? -22.590 -59.196 32.231  1.00 29.36 ?  294  HOH C O   1 
HETATM 7183 O O   . HOH U 7 .   ? -38.318 -76.849 18.985  1.00 36.94 ?  295  HOH C O   1 
HETATM 7184 O O   . HOH U 7 .   ? -40.478 -75.188 21.293  1.00 37.51 ?  296  HOH C O   1 
HETATM 7185 O O   . HOH U 7 .   ? -22.627 -61.431 28.686  1.00 27.44 ?  297  HOH C O   1 
HETATM 7186 O O   . HOH U 7 .   ? -34.835 -52.061 6.031   1.00 33.55 ?  298  HOH C O   1 
HETATM 7187 O O   . HOH U 7 .   ? -30.149 -68.425 31.299  1.00 35.14 ?  299  HOH C O   1 
HETATM 7188 O O   . HOH V 7 .   ? -5.650  -8.048  48.833  1.00 41.95 ?  701  HOH B O   1 
HETATM 7189 O O   . HOH V 7 .   ? 0.690   -29.095 37.398  1.00 25.55 ?  702  HOH B O   1 
HETATM 7190 O O   . HOH V 7 .   ? -12.675 -18.934 47.415  1.00 33.93 ?  703  HOH B O   1 
HETATM 7191 O O   . HOH V 7 .   ? -30.685 -11.036 9.491   1.00 38.61 ?  704  HOH B O   1 
HETATM 7192 O O   . HOH V 7 .   ? -3.535  -9.758  18.821  1.00 20.59 ?  705  HOH B O   1 
HETATM 7193 O O   . HOH V 7 .   ? -24.167 -23.343 22.319  1.00 17.37 ?  706  HOH B O   1 
HETATM 7194 O O   . HOH V 7 .   ? -27.607 -17.192 30.842  1.00 34.71 ?  707  HOH B O   1 
HETATM 7195 O O   . HOH V 7 .   ? -46.831 -30.686 19.655  1.00 22.82 ?  708  HOH B O   1 
HETATM 7196 O O   . HOH V 7 .   ? 15.792  -22.504 36.128  1.00 36.20 ?  709  HOH B O   1 
HETATM 7197 O O   . HOH V 7 .   ? -32.696 -14.765 6.101   1.00 35.51 ?  710  HOH B O   1 
HETATM 7198 O O   . HOH V 7 .   ? -27.744 -39.933 11.051  1.00 21.15 ?  711  HOH B O   1 
HETATM 7199 O O   . HOH V 7 .   ? -42.147 -38.521 12.978  1.00 26.89 ?  712  HOH B O   1 
HETATM 7200 O O   . HOH V 7 .   ? -21.522 -29.803 32.963  1.00 16.93 ?  713  HOH B O   1 
HETATM 7201 O O   . HOH V 7 .   ? -31.662 -11.116 12.617  1.00 36.56 ?  714  HOH B O   1 
HETATM 7202 O O   . HOH V 7 .   ? -4.163  -11.722 46.152  1.00 20.84 ?  715  HOH B O   1 
HETATM 7203 O O   . HOH V 7 .   ? -4.566  -8.783  16.953  1.00 22.81 ?  716  HOH B O   1 
HETATM 7204 O O   . HOH V 7 .   ? -6.944  -17.697 -1.583  1.00 26.94 ?  717  HOH B O   1 
HETATM 7205 O O   . HOH V 7 .   ? -29.950 -21.216 25.779  1.00 21.54 ?  718  HOH B O   1 
HETATM 7206 O O   . HOH V 7 .   ? -28.211 -21.574 12.377  1.00 11.58 ?  719  HOH B O   1 
HETATM 7207 O O   . HOH V 7 .   ? -19.855 -10.107 30.841  1.00 29.61 ?  720  HOH B O   1 
HETATM 7208 O O   . HOH V 7 .   ? 5.812   -11.067 16.544  1.00 17.72 ?  721  HOH B O   1 
HETATM 7209 O O   . HOH V 7 .   ? -8.827  -7.917  42.149  1.00 21.34 ?  722  HOH B O   1 
HETATM 7210 O O   . HOH V 7 .   ? 11.901  -10.450 19.462  1.00 28.94 ?  723  HOH B O   1 
HETATM 7211 O O   . HOH V 7 .   ? 7.167   -23.352 13.325  1.00 24.51 ?  724  HOH B O   1 
HETATM 7212 O O   . HOH V 7 .   ? -20.101 -36.401 11.531  1.00 17.41 ?  725  HOH B O   1 
HETATM 7213 O O   . HOH V 7 .   ? -21.269 -14.279 36.268  1.00 34.14 ?  726  HOH B O   1 
HETATM 7214 O O   . HOH V 7 .   ? -12.881 -5.581  18.480  1.00 26.70 ?  727  HOH B O   1 
HETATM 7215 O O   . HOH V 7 .   ? -42.257 -41.701 18.975  1.00 20.81 ?  728  HOH B O   1 
HETATM 7216 O O   . HOH V 7 .   ? 1.949   -8.118  27.204  1.00 21.42 ?  729  HOH B O   1 
HETATM 7217 O O   . HOH V 7 .   ? -22.362 -15.813 34.200  1.00 27.79 ?  730  HOH B O   1 
HETATM 7218 O O   . HOH V 7 .   ? 12.170  -23.782 40.209  1.00 33.38 ?  731  HOH B O   1 
HETATM 7219 O O   . HOH V 7 .   ? -1.590  -12.265 49.524  1.00 42.06 ?  732  HOH B O   1 
HETATM 7220 O O   . HOH V 7 .   ? 0.495   -26.112 15.745  1.00 12.94 ?  733  HOH B O   1 
HETATM 7221 O O   . HOH V 7 .   ? -5.406  -18.776 44.490  1.00 15.37 ?  734  HOH B O   1 
HETATM 7222 O O   . HOH V 7 .   ? 5.356   -32.707 25.932  1.00 20.58 ?  735  HOH B O   1 
HETATM 7223 O O   . HOH V 7 .   ? -0.979  -28.574 14.998  1.00 23.92 ?  736  HOH B O   1 
HETATM 7224 O O   . HOH V 7 .   ? -20.115 -5.028  18.944  1.00 35.86 ?  737  HOH B O   1 
HETATM 7225 O O   . HOH V 7 .   ? -47.514 -30.732 5.677   1.00 10.71 ?  738  HOH B O   1 
HETATM 7226 O O   . HOH V 7 .   ? -40.172 -22.924 15.503  1.00 35.44 ?  739  HOH B O   1 
HETATM 7227 O O   . HOH V 7 .   ? -8.538  -7.510  28.172  1.00 18.28 ?  740  HOH B O   1 
HETATM 7228 O O   . HOH V 7 .   ? -9.839  -23.228 12.915  1.00 8.98  ?  741  HOH B O   1 
HETATM 7229 O O   . HOH V 7 .   ? -35.089 -27.335 2.893   1.00 21.92 ?  742  HOH B O   1 
HETATM 7230 O O   . HOH V 7 .   ? 0.225   -16.632 14.214  1.00 19.72 ?  743  HOH B O   1 
HETATM 7231 O O   . HOH V 7 .   ? -25.214 -22.967 25.183  1.00 27.20 ?  744  HOH B O   1 
HETATM 7232 O O   . HOH V 7 .   ? -7.584  -6.276  25.819  1.00 14.99 ?  745  HOH B O   1 
HETATM 7233 O O   . HOH V 7 .   ? 0.957   -23.734 40.052  1.00 13.12 ?  746  HOH B O   1 
HETATM 7234 O O   . HOH V 7 .   ? 12.601  -30.009 30.844  1.00 27.80 ?  747  HOH B O   1 
HETATM 7235 O O   . HOH V 7 .   ? -24.529 -10.223 20.559  1.00 14.04 ?  748  HOH B O   1 
HETATM 7236 O O   . HOH V 7 .   ? -14.766 -12.830 41.662  1.00 31.35 ?  749  HOH B O   1 
HETATM 7237 O O   . HOH V 7 .   ? -21.714 -28.955 4.198   1.00 10.62 ?  750  HOH B O   1 
HETATM 7238 O O   . HOH V 7 .   ? -44.422 -46.735 22.379  1.00 30.05 ?  751  HOH B O   1 
HETATM 7239 O O   . HOH V 7 .   ? -30.519 -8.962  19.561  1.00 20.56 ?  752  HOH B O   1 
HETATM 7240 O O   . HOH V 7 .   ? -27.148 -34.989 21.127  1.00 8.54  ?  753  HOH B O   1 
HETATM 7241 O O   . HOH V 7 .   ? -19.764 -17.339 21.935  1.00 9.04  ?  754  HOH B O   1 
HETATM 7242 O O   . HOH V 7 .   ? 2.569   -5.861  30.330  1.00 19.63 ?  755  HOH B O   1 
HETATM 7243 O O   . HOH V 7 .   ? -15.352 -21.604 28.161  1.00 6.94  ?  756  HOH B O   1 
HETATM 7244 O O   . HOH V 7 .   ? -10.394 -27.207 -0.386  1.00 12.14 ?  757  HOH B O   1 
HETATM 7245 O O   . HOH V 7 .   ? -22.968 -15.403 11.725  1.00 11.39 ?  758  HOH B O   1 
HETATM 7246 O O   . HOH V 7 .   ? -29.642 -32.459 4.453   1.00 19.00 ?  759  HOH B O   1 
HETATM 7247 O O   . HOH V 7 .   ? 15.758  -15.648 28.430  1.00 28.66 ?  760  HOH B O   1 
HETATM 7248 O O   . HOH V 7 .   ? -18.784 -10.115 33.342  1.00 27.39 ?  761  HOH B O   1 
HETATM 7249 O O   . HOH V 7 .   ? 0.786   -18.557 45.135  1.00 25.63 ?  762  HOH B O   1 
HETATM 7250 O O   . HOH V 7 .   ? -43.960 -29.593 8.843   1.00 23.89 ?  763  HOH B O   1 
HETATM 7251 O O   . HOH V 7 .   ? -4.494  -21.841 11.899  1.00 14.25 ?  764  HOH B O   1 
HETATM 7252 O O   . HOH V 7 .   ? -44.799 -36.852 20.147  1.00 17.86 ?  765  HOH B O   1 
HETATM 7253 O O   . HOH V 7 .   ? -29.567 -41.713 12.299  1.00 30.95 ?  766  HOH B O   1 
HETATM 7254 O O   . HOH V 7 .   ? -0.759  -7.334  26.225  1.00 17.01 ?  767  HOH B O   1 
HETATM 7255 O O   . HOH V 7 .   ? -45.720 -33.449 20.165  1.00 21.18 ?  768  HOH B O   1 
HETATM 7256 O O   . HOH V 7 .   ? -1.180  -32.548 37.971  1.00 16.27 ?  769  HOH B O   1 
HETATM 7257 O O   . HOH V 7 .   ? -26.698 -9.226  19.087  1.00 17.28 ?  770  HOH B O   1 
HETATM 7258 O O   . HOH V 7 .   ? -7.936  -32.294 21.405  1.00 11.19 ?  771  HOH B O   1 
HETATM 7259 O O   . HOH V 7 .   ? -35.921 -19.580 22.404  1.00 21.55 ?  772  HOH B O   1 
HETATM 7260 O O   . HOH V 7 .   ? -39.901 -40.258 29.573  1.00 26.11 ?  773  HOH B O   1 
HETATM 7261 O O   . HOH V 7 .   ? -14.155 -9.062  16.593  1.00 23.12 ?  774  HOH B O   1 
HETATM 7262 O O   . HOH V 7 .   ? -46.637 -41.871 29.657  1.00 40.32 ?  775  HOH B O   1 
HETATM 7263 O O   . HOH V 7 .   ? -4.238  -5.752  29.039  1.00 26.12 ?  776  HOH B O   1 
HETATM 7264 O O   . HOH V 7 .   ? 8.335   -8.190  27.495  1.00 11.48 ?  777  HOH B O   1 
HETATM 7265 O O   . HOH V 7 .   ? -16.751 -24.009 1.663   1.00 7.95  ?  778  HOH B O   1 
HETATM 7266 O O   . HOH V 7 .   ? -19.372 -12.673 11.110  1.00 16.41 ?  779  HOH B O   1 
HETATM 7267 O O   . HOH V 7 .   ? -39.388 -34.576 25.607  1.00 18.91 ?  780  HOH B O   1 
HETATM 7268 O O   . HOH V 7 .   ? -41.383 -28.052 18.663  1.00 13.32 ?  781  HOH B O   1 
HETATM 7269 O O   . HOH V 7 .   ? -39.052 -30.817 19.526  1.00 9.97  ?  782  HOH B O   1 
HETATM 7270 O O   . HOH V 7 .   ? 6.611   -19.352 43.593  1.00 28.28 ?  783  HOH B O   1 
HETATM 7271 O O   . HOH V 7 .   ? -27.301 -23.627 10.478  1.00 12.53 ?  784  HOH B O   1 
HETATM 7272 O O   . HOH V 7 .   ? -16.443 -21.586 21.077  1.00 7.02  ?  785  HOH B O   1 
HETATM 7273 O O   . HOH V 7 .   ? -32.541 -38.661 23.425  1.00 8.74  ?  786  HOH B O   1 
HETATM 7274 O O   . HOH V 7 .   ? -16.170 -24.629 8.680   1.00 7.10  ?  787  HOH B O   1 
HETATM 7275 O O   . HOH V 7 .   ? -26.407 -39.915 7.461   1.00 31.96 ?  788  HOH B O   1 
HETATM 7276 O O   . HOH V 7 .   ? -37.352 -26.081 7.708   1.00 13.09 ?  789  HOH B O   1 
HETATM 7277 O O   . HOH V 7 .   ? -24.115 -36.011 24.410  1.00 11.96 ?  790  HOH B O   1 
HETATM 7278 O O   . HOH V 7 .   ? -35.345 -40.450 8.482   1.00 19.01 ?  791  HOH B O   1 
HETATM 7279 O O   . HOH V 7 .   ? -25.690 -15.033 11.586  1.00 11.63 ?  792  HOH B O   1 
HETATM 7280 O O   . HOH V 7 .   ? -36.493 -45.060 27.361  1.00 11.79 ?  793  HOH B O   1 
HETATM 7281 O O   . HOH V 7 .   ? -25.507 -9.810  16.353  1.00 14.07 ?  794  HOH B O   1 
HETATM 7282 O O   . HOH V 7 .   ? 3.427   -27.492 23.940  1.00 11.27 ?  795  HOH B O   1 
HETATM 7283 O O   . HOH V 7 .   ? -36.786 -20.889 25.700  1.00 24.00 ?  796  HOH B O   1 
HETATM 7284 O O   . HOH V 7 .   ? -39.496 -41.806 11.152  1.00 36.53 ?  797  HOH B O   1 
HETATM 7285 O O   . HOH V 7 .   ? -16.060 -33.503 21.977  1.00 14.08 ?  798  HOH B O   1 
HETATM 7286 O O   . HOH V 7 .   ? -23.314 -3.262  19.129  1.00 34.69 ?  799  HOH B O   1 
HETATM 7287 O O   . HOH V 7 .   ? -3.495  -27.891 15.968  1.00 15.80 ?  800  HOH B O   1 
HETATM 7288 O O   . HOH V 7 .   ? -12.068 -13.402 17.589  1.00 11.35 ?  801  HOH B O   1 
HETATM 7289 O O   . HOH V 7 .   ? 2.576   -29.521 30.472  1.00 10.70 ?  802  HOH B O   1 
HETATM 7290 O O   . HOH V 7 .   ? 11.004  -11.448 21.586  1.00 20.12 ?  803  HOH B O   1 
HETATM 7291 O O   . HOH V 7 .   ? -17.741 -31.497 3.013   1.00 18.00 ?  804  HOH B O   1 
HETATM 7292 O O   . HOH V 7 .   ? -28.855 -21.808 8.904   1.00 19.33 ?  805  HOH B O   1 
HETATM 7293 O O   . HOH V 7 .   ? -10.240 -13.262 29.392  1.00 9.86  ?  806  HOH B O   1 
HETATM 7294 O O   . HOH V 7 .   ? 0.336   -34.992 31.715  1.00 21.47 ?  807  HOH B O   1 
HETATM 7295 O O   . HOH V 7 .   ? -22.505 -36.582 13.020  1.00 12.55 ?  808  HOH B O   1 
HETATM 7296 O O   . HOH V 7 .   ? -29.609 -30.312 31.761  1.00 26.16 ?  809  HOH B O   1 
HETATM 7297 O O   . HOH V 7 .   ? 12.422  -16.931 34.173  1.00 28.71 ?  810  HOH B O   1 
HETATM 7298 O O   . HOH V 7 .   ? 3.645   -32.666 36.890  1.00 20.36 ?  811  HOH B O   1 
HETATM 7299 O O   . HOH V 7 .   ? 0.562   -12.469 19.069  1.00 11.21 ?  812  HOH B O   1 
HETATM 7300 O O   . HOH V 7 .   ? -26.255 -21.393 22.112  1.00 18.80 ?  813  HOH B O   1 
HETATM 7301 O O   . HOH V 7 .   ? -28.095 -9.216  32.456  1.00 33.93 ?  814  HOH B O   1 
HETATM 7302 O O   . HOH V 7 .   ? -6.647  -8.491  18.567  1.00 13.63 ?  815  HOH B O   1 
HETATM 7303 O O   . HOH V 7 .   ? -14.211 -22.725 47.390  1.00 28.45 ?  816  HOH B O   1 
HETATM 7304 O O   . HOH V 7 .   ? -7.127  -33.449 29.213  1.00 8.94  ?  817  HOH B O   1 
HETATM 7305 O O   . HOH V 7 .   ? 0.329   -4.863  29.034  1.00 28.99 ?  818  HOH B O   1 
HETATM 7306 O O   . HOH V 7 .   ? -18.886 -33.447 22.423  1.00 9.52  ?  819  HOH B O   1 
HETATM 7307 O O   . HOH V 7 .   ? -6.126  -12.237 40.645  1.00 11.25 ?  820  HOH B O   1 
HETATM 7308 O O   . HOH V 7 .   ? -43.347 -27.621 2.169   1.00 20.05 ?  821  HOH B O   1 
HETATM 7309 O O   . HOH V 7 .   ? -15.384 -5.380  24.401  1.00 29.15 ?  822  HOH B O   1 
HETATM 7310 O O   . HOH V 7 .   ? -3.649  -16.257 26.215  1.00 9.17  ?  823  HOH B O   1 
HETATM 7311 O O   . HOH V 7 .   ? -24.485 -14.658 6.818   1.00 15.19 ?  824  HOH B O   1 
HETATM 7312 O O   . HOH V 7 .   ? -35.937 -13.320 20.578  1.00 34.75 ?  825  HOH B O   1 
HETATM 7313 O O   . HOH V 7 .   ? 11.773  -17.446 15.675  1.00 23.69 ?  826  HOH B O   1 
HETATM 7314 O O   . HOH V 7 .   ? 14.236  -4.211  29.876  1.00 20.98 ?  827  HOH B O   1 
HETATM 7315 O O   . HOH V 7 .   ? -29.492 -24.250 24.358  1.00 16.55 ?  828  HOH B O   1 
HETATM 7316 O O   . HOH V 7 .   ? 3.110   -8.604  14.130  1.00 33.43 ?  829  HOH B O   1 
HETATM 7317 O O   . HOH V 7 .   ? -25.381 -25.385 26.552  1.00 28.32 ?  830  HOH B O   1 
HETATM 7318 O O   . HOH V 7 .   ? -1.722  -23.798 42.931  1.00 20.70 ?  831  HOH B O   1 
HETATM 7319 O O   . HOH V 7 .   ? -9.361  -20.857 11.799  1.00 10.27 ?  832  HOH B O   1 
HETATM 7320 O O   . HOH V 7 .   ? -2.561  -6.569  31.965  1.00 17.55 ?  833  HOH B O   1 
HETATM 7321 O O   . HOH V 7 .   ? -9.184  -26.116 37.911  1.00 21.15 ?  834  HOH B O   1 
HETATM 7322 O O   . HOH V 7 .   ? -13.365 -15.786 17.802  1.00 11.06 ?  835  HOH B O   1 
HETATM 7323 O O   . HOH V 7 .   ? -10.487 -9.498  28.956  1.00 12.79 ?  836  HOH B O   1 
HETATM 7324 O O   . HOH V 7 .   ? -8.725  -31.361 34.153  1.00 10.77 ?  837  HOH B O   1 
HETATM 7325 O O   . HOH V 7 .   ? -10.354 -18.095 25.301  1.00 8.18  ?  838  HOH B O   1 
HETATM 7326 O O   . HOH V 7 .   ? -38.999 -46.304 27.813  1.00 14.25 ?  839  HOH B O   1 
HETATM 7327 O O   . HOH V 7 .   ? -5.096  -24.961 45.121  1.00 30.18 ?  840  HOH B O   1 
HETATM 7328 O O   . HOH V 7 .   ? 8.599   -27.524 40.913  1.00 38.94 ?  841  HOH B O   1 
HETATM 7329 O O   . HOH V 7 .   ? 12.343  -16.342 21.837  1.00 20.30 ?  842  HOH B O   1 
HETATM 7330 O O   . HOH V 7 .   ? 2.791   -32.071 26.497  1.00 13.56 ?  843  HOH B O   1 
HETATM 7331 O O   . HOH V 7 .   ? 8.768   -14.977 27.556  1.00 10.51 ?  844  HOH B O   1 
HETATM 7332 O O   . HOH V 7 .   ? -2.656  -31.603 15.004  1.00 24.21 ?  845  HOH B O   1 
HETATM 7333 O O   . HOH V 7 .   ? -29.383 -13.388 26.275  1.00 24.99 ?  846  HOH B O   1 
HETATM 7334 O O   . HOH V 7 .   ? -35.120 -20.405 11.829  1.00 25.52 ?  847  HOH B O   1 
HETATM 7335 O O   . HOH V 7 .   ? -11.975 -14.097 47.558  1.00 33.37 ?  848  HOH B O   1 
HETATM 7336 O O   . HOH V 7 .   ? -8.331  -16.392 41.570  1.00 12.14 ?  849  HOH B O   1 
HETATM 7337 O O   . HOH V 7 .   ? -37.584 -24.174 9.844   1.00 22.03 ?  850  HOH B O   1 
HETATM 7338 O O   . HOH V 7 .   ? 12.163  -9.317  25.935  1.00 21.18 ?  851  HOH B O   1 
HETATM 7339 O O   . HOH V 7 .   ? -15.754 -15.746 41.227  1.00 17.23 ?  852  HOH B O   1 
HETATM 7340 O O   . HOH V 7 .   ? -20.416 -33.368 5.992   1.00 17.20 ?  853  HOH B O   1 
HETATM 7341 O O   . HOH V 7 .   ? -5.266  -6.970  32.085  1.00 13.69 ?  854  HOH B O   1 
HETATM 7342 O O   . HOH V 7 .   ? -32.685 -40.419 8.414   1.00 20.03 ?  855  HOH B O   1 
HETATM 7343 O O   . HOH V 7 .   ? -27.716 -26.299 26.117  1.00 24.65 ?  856  HOH B O   1 
HETATM 7344 O O   . HOH V 7 .   ? -41.872 -33.644 6.126   1.00 13.61 ?  857  HOH B O   1 
HETATM 7345 O O   . HOH V 7 .   ? 12.531  -20.823 40.333  1.00 35.20 ?  858  HOH B O   1 
HETATM 7346 O O   . HOH V 7 .   ? -8.930  -20.837 8.360   1.00 13.12 ?  859  HOH B O   1 
HETATM 7347 O O   . HOH V 7 .   ? -18.752 -5.713  27.069  1.00 34.63 ?  860  HOH B O   1 
HETATM 7348 O O   . HOH V 7 .   ? -19.504 -36.437 7.548   1.00 19.66 ?  861  HOH B O   1 
HETATM 7349 O O   . HOH V 7 .   ? -20.983 -7.061  15.483  1.00 27.81 ?  862  HOH B O   1 
HETATM 7350 O O   . HOH V 7 .   ? -18.507 -9.640  28.484  1.00 19.66 ?  863  HOH B O   1 
HETATM 7351 O O   . HOH V 7 .   ? -15.207 -23.680 39.781  1.00 15.62 ?  864  HOH B O   1 
HETATM 7352 O O   . HOH V 7 .   ? -28.155 -22.060 30.094  1.00 37.38 ?  865  HOH B O   1 
HETATM 7353 O O   . HOH V 7 .   ? 11.316  -16.999 29.135  1.00 13.56 ?  866  HOH B O   1 
HETATM 7354 O O   . HOH V 7 .   ? -20.788 -15.202 7.564   1.00 13.13 ?  867  HOH B O   1 
HETATM 7355 O O   . HOH V 7 .   ? -12.422 -29.123 33.359  1.00 8.85  ?  868  HOH B O   1 
HETATM 7356 O O   . HOH V 7 .   ? 7.313   -10.337 18.677  1.00 19.43 ?  869  HOH B O   1 
HETATM 7357 O O   . HOH V 7 .   ? -10.186 -11.763 12.965  1.00 14.92 ?  870  HOH B O   1 
HETATM 7358 O O   . HOH V 7 .   ? -31.371 -18.038 29.592  1.00 35.78 ?  871  HOH B O   1 
HETATM 7359 O O   . HOH V 7 .   ? -9.048  -25.764 -2.454  1.00 13.14 ?  872  HOH B O   1 
HETATM 7360 O O   . HOH V 7 .   ? -21.671 -21.081 8.035   1.00 9.82  ?  873  HOH B O   1 
HETATM 7361 O O   . HOH V 7 .   ? 0.653   -4.420  36.362  1.00 22.76 ?  874  HOH B O   1 
HETATM 7362 O O   . HOH V 7 .   ? -9.866  -16.745 11.673  1.00 12.31 ?  875  HOH B O   1 
HETATM 7363 O O   . HOH V 7 .   ? -1.618  -12.672 45.326  1.00 16.01 ?  876  HOH B O   1 
HETATM 7364 O O   . HOH V 7 .   ? -33.751 -29.976 2.922   1.00 21.55 ?  877  HOH B O   1 
HETATM 7365 O O   . HOH V 7 .   ? 9.458   -8.523  25.046  1.00 13.94 ?  878  HOH B O   1 
HETATM 7366 O O   . HOH V 7 .   ? 12.973  -19.114 28.230  1.00 23.16 ?  879  HOH B O   1 
HETATM 7367 O O   . HOH V 7 .   ? 6.064   -25.324 15.384  1.00 18.05 ?  880  HOH B O   1 
HETATM 7368 O O   . HOH V 7 .   ? -0.409  -11.755 12.364  1.00 23.00 ?  881  HOH B O   1 
HETATM 7369 O O   . HOH V 7 .   ? -6.097  -19.834 12.965  1.00 19.65 ?  882  HOH B O   1 
HETATM 7370 O O   . HOH V 7 .   ? -38.528 -21.091 32.615  1.00 32.38 ?  883  HOH B O   1 
HETATM 7371 O O   . HOH V 7 .   ? -39.879 -24.402 11.125  1.00 23.35 ?  884  HOH B O   1 
HETATM 7372 O O   . HOH V 7 .   ? -5.841  -27.987 10.240  1.00 8.75  ?  885  HOH B O   1 
HETATM 7373 O O   . HOH V 7 .   ? -45.132 -32.288 24.468  1.00 30.25 ?  886  HOH B O   1 
HETATM 7374 O O   . HOH V 7 .   ? -6.178  -18.050 41.969  1.00 13.62 ?  887  HOH B O   1 
HETATM 7375 O O   . HOH V 7 .   ? -44.652 -37.162 24.761  1.00 21.59 ?  888  HOH B O   1 
HETATM 7376 O O   . HOH V 7 .   ? 12.333  -14.511 19.076  1.00 19.13 ?  889  HOH B O   1 
HETATM 7377 O O   . HOH V 7 .   ? 0.767   -21.084 41.093  1.00 12.84 ?  890  HOH B O   1 
HETATM 7378 O O   . HOH V 7 .   ? 3.865   -10.550 44.247  1.00 22.73 ?  891  HOH B O   1 
HETATM 7379 O O   . HOH V 7 .   ? -4.853  -6.636  25.053  1.00 15.70 ?  892  HOH B O   1 
HETATM 7380 O O   . HOH V 7 .   ? 7.203   -6.953  18.285  1.00 28.29 ?  893  HOH B O   1 
HETATM 7381 O O   . HOH V 7 .   ? 7.503   -5.313  38.973  1.00 20.37 ?  894  HOH B O   1 
HETATM 7382 O O   . HOH V 7 .   ? -12.063 -4.747  21.894  1.00 19.41 ?  895  HOH B O   1 
HETATM 7383 O O   . HOH V 7 .   ? 1.997   -19.945 43.248  1.00 22.20 ?  896  HOH B O   1 
HETATM 7384 O O   . HOH V 7 .   ? -37.877 -31.234 30.493  1.00 38.22 ?  897  HOH B O   1 
HETATM 7385 O O   . HOH V 7 .   ? 2.494   -30.215 24.467  1.00 13.32 ?  898  HOH B O   1 
HETATM 7386 O O   . HOH V 7 .   ? -0.135  -36.328 33.618  1.00 33.37 ?  899  HOH B O   1 
HETATM 7387 O O   . HOH V 7 .   ? -22.592 -3.792  24.108  1.00 22.74 ?  900  HOH B O   1 
HETATM 7388 O O   . HOH V 7 .   ? -9.333  -3.671  36.560  1.00 41.31 ?  901  HOH B O   1 
HETATM 7389 O O   . HOH V 7 .   ? 8.164   -24.997 42.251  1.00 36.99 ?  902  HOH B O   1 
HETATM 7390 O O   . HOH V 7 .   ? 7.746   -2.327  40.156  1.00 25.75 ?  903  HOH B O   1 
HETATM 7391 O O   . HOH V 7 .   ? -18.456 -8.548  16.531  1.00 20.71 ?  904  HOH B O   1 
HETATM 7392 O O   . HOH V 7 .   ? -33.905 -23.071 37.789  1.00 28.63 ?  905  HOH B O   1 
HETATM 7393 O O   . HOH V 7 .   ? 1.520   -31.842 29.041  1.00 11.41 ?  906  HOH B O   1 
HETATM 7394 O O   . HOH V 7 .   ? -28.666 -7.803  25.337  1.00 27.40 ?  907  HOH B O   1 
HETATM 7395 O O   . HOH V 7 .   ? 2.234   -0.608  36.596  1.00 26.69 ?  908  HOH B O   1 
HETATM 7396 O O   . HOH V 7 .   ? -30.786 -39.881 4.859   1.00 36.98 ?  909  HOH B O   1 
HETATM 7397 O O   . HOH V 7 .   ? -13.998 -11.224 14.981  1.00 19.87 ?  910  HOH B O   1 
HETATM 7398 O O   . HOH V 7 .   ? -2.225  -37.296 27.826  1.00 24.69 ?  911  HOH B O   1 
HETATM 7399 O O   . HOH V 7 .   ? -18.097 -21.373 27.901  1.00 8.11  ?  912  HOH B O   1 
HETATM 7400 O O   . HOH V 7 .   ? -27.129 -18.661 28.919  1.00 20.08 ?  913  HOH B O   1 
HETATM 7401 O O   . HOH V 7 .   ? -33.239 -16.766 12.425  1.00 33.08 ?  914  HOH B O   1 
HETATM 7402 O O   . HOH V 7 .   ? 6.408   -30.901 23.592  1.00 16.66 ?  915  HOH B O   1 
HETATM 7403 O O   . HOH V 7 .   ? -9.233  -4.085  23.078  1.00 32.12 ?  916  HOH B O   1 
HETATM 7404 O O   . HOH V 7 .   ? -35.947 -38.718 5.965   1.00 19.68 ?  917  HOH B O   1 
HETATM 7405 O O   . HOH V 7 .   ? -19.561 -5.247  22.800  1.00 20.77 ?  918  HOH B O   1 
HETATM 7406 O O   . HOH V 7 .   ? -20.029 -32.211 24.546  1.00 16.34 ?  919  HOH B O   1 
HETATM 7407 O O   . HOH V 7 .   ? -27.280 -34.115 28.539  1.00 17.85 ?  920  HOH B O   1 
HETATM 7408 O O   . HOH V 7 .   ? -31.112 -29.975 4.022   1.00 22.05 ?  921  HOH B O   1 
HETATM 7409 O O   . HOH V 7 .   ? -32.390 -42.733 15.149  1.00 18.37 ?  922  HOH B O   1 
HETATM 7410 O O   . HOH V 7 .   ? -29.647 -23.376 32.643  1.00 29.84 ?  923  HOH B O   1 
HETATM 7411 O O   . HOH V 7 .   ? -15.735 -4.882  20.515  1.00 25.48 ?  924  HOH B O   1 
HETATM 7412 O O   . HOH V 7 .   ? -10.578 -28.189 37.236  1.00 14.00 ?  925  HOH B O   1 
HETATM 7413 O O   . HOH V 7 .   ? -34.148 -24.289 4.980   1.00 36.44 ?  926  HOH B O   1 
HETATM 7414 O O   . HOH V 7 .   ? -4.973  -21.889 47.104  1.00 38.85 ?  927  HOH B O   1 
HETATM 7415 O O   . HOH V 7 .   ? -9.122  -12.248 49.798  1.00 39.04 ?  928  HOH B O   1 
HETATM 7416 O O   . HOH V 7 .   ? -13.505 -7.780  40.801  1.00 40.45 ?  929  HOH B O   1 
HETATM 7417 O O   . HOH V 7 .   ? -29.417 -19.939 28.297  1.00 27.49 ?  930  HOH B O   1 
HETATM 7418 O O   . HOH V 7 .   ? 1.637   -19.590 8.317   1.00 42.46 ?  931  HOH B O   1 
HETATM 7419 O O   . HOH V 7 .   ? 4.614   -29.318 20.841  1.00 32.84 ?  932  HOH B O   1 
HETATM 7420 O O   . HOH V 7 .   ? -2.968  -21.602 9.256   1.00 34.32 ?  933  HOH B O   1 
HETATM 7421 O O   . HOH V 7 .   ? 14.757  -21.287 26.566  1.00 39.31 ?  934  HOH B O   1 
HETATM 7422 O O   . HOH V 7 .   ? -28.282 -24.917 34.336  1.00 29.37 ?  935  HOH B O   1 
HETATM 7423 O O   . HOH V 7 .   ? -31.577 -21.071 33.908  1.00 40.66 ?  936  HOH B O   1 
HETATM 7424 O O   . HOH V 7 .   ? -25.381 -31.240 2.845   1.00 24.96 ?  937  HOH B O   1 
HETATM 7425 O O   . HOH V 7 .   ? -36.798 -24.902 5.496   1.00 29.89 ?  938  HOH B O   1 
HETATM 7426 O O   . HOH V 7 .   ? -27.025 -40.049 13.964  1.00 21.18 ?  939  HOH B O   1 
HETATM 7427 O O   . HOH V 7 .   ? 1.808   1.843   35.897  1.00 31.56 ?  940  HOH B O   1 
HETATM 7428 O O   . HOH V 7 .   ? -6.290  -5.005  33.680  1.00 25.59 ?  941  HOH B O   1 
HETATM 7429 O O   . HOH V 7 .   ? -21.113 -5.728  28.968  1.00 38.71 ?  942  HOH B O   1 
HETATM 7430 O O   . HOH V 7 .   ? -16.678 -7.722  28.880  1.00 28.76 ?  943  HOH B O   1 
HETATM 7431 O O   . HOH V 7 .   ? -15.879 -25.661 37.941  1.00 11.94 ?  944  HOH B O   1 
HETATM 7432 O O   . HOH V 7 .   ? -45.980 -37.928 22.481  1.00 17.08 ?  945  HOH B O   1 
HETATM 7433 O O   . HOH V 7 .   ? -13.713 -25.710 41.873  1.00 26.72 ?  946  HOH B O   1 
HETATM 7434 O O   . HOH V 7 .   ? 12.782  -13.600 21.679  1.00 27.10 ?  947  HOH B O   1 
HETATM 7435 O O   . HOH V 7 .   ? -6.620  -4.824  21.645  1.00 31.55 ?  948  HOH B O   1 
HETATM 7436 O O   . HOH V 7 .   ? -3.955  -4.416  23.779  1.00 31.55 ?  949  HOH B O   1 
HETATM 7437 O O   . HOH V 7 .   ? 9.067   -19.835 43.691  1.00 44.00 ?  950  HOH B O   1 
HETATM 7438 O O   . HOH V 7 .   ? -41.630 -43.595 30.196  1.00 34.66 ?  951  HOH B O   1 
HETATM 7439 O O   . HOH V 7 .   ? -32.212 -10.283 21.689  1.00 32.66 ?  952  HOH B O   1 
HETATM 7440 O O   . HOH V 7 .   ? -46.746 -33.625 22.734  1.00 29.24 ?  953  HOH B O   1 
HETATM 7441 O O   . HOH V 7 .   ? -9.333  -15.290 4.731   1.00 32.89 ?  954  HOH B O   1 
HETATM 7442 O O   . HOH V 7 .   ? -44.161 -24.976 8.843   1.00 31.91 ?  955  HOH B O   1 
HETATM 7443 O O   . HOH V 7 .   ? -37.960 -36.003 27.601  1.00 31.11 ?  956  HOH B O   1 
HETATM 7444 O O   . HOH V 7 .   ? -9.816  -7.320  34.524  1.00 20.33 ?  957  HOH B O   1 
HETATM 7445 O O   . HOH V 7 .   ? 13.620  -17.691 36.536  1.00 28.28 ?  958  HOH B O   1 
HETATM 7446 O O   . HOH V 7 .   ? 3.684   -12.842 45.446  1.00 41.88 ?  959  HOH B O   1 
HETATM 7447 O O   . HOH V 7 .   ? 13.093  -17.733 31.549  1.00 26.81 ?  960  HOH B O   1 
HETATM 7448 O O   . HOH V 7 .   ? -9.326  -13.893 11.084  1.00 23.13 ?  961  HOH B O   1 
HETATM 7449 O O   . HOH V 7 .   ? -5.131  -30.045 8.434   1.00 11.10 ?  962  HOH B O   1 
HETATM 7450 O O   . HOH V 7 .   ? -11.807 -14.803 4.776   1.00 20.66 ?  963  HOH B O   1 
HETATM 7451 O O   . HOH V 7 .   ? -30.912 -22.410 7.520   1.00 32.50 ?  964  HOH B O   1 
HETATM 7452 O O   . HOH V 7 .   ? 11.294  -20.684 43.477  1.00 39.38 ?  965  HOH B O   1 
HETATM 7453 O O   . HOH V 7 .   ? -21.459 -13.956 9.922   1.00 12.99 ?  966  HOH B O   1 
HETATM 7454 O O   . HOH V 7 .   ? -7.047  -18.591 8.779   1.00 33.18 ?  967  HOH B O   1 
HETATM 7455 O O   . HOH V 7 .   ? -8.433  -3.808  25.901  1.00 31.60 ?  968  HOH B O   1 
HETATM 7456 O O   . HOH V 7 .   ? -47.370 -29.533 3.278   1.00 13.53 ?  969  HOH B O   1 
HETATM 7457 O O   . HOH V 7 .   ? -7.741  -18.736 11.348  1.00 20.95 ?  970  HOH B O   1 
HETATM 7458 O O   . HOH V 7 .   ? -17.561 -33.398 26.044  1.00 17.89 ?  971  HOH B O   1 
HETATM 7459 O O   . HOH V 7 .   ? -40.273 -32.314 -0.776  1.00 24.44 ?  972  HOH B O   1 
HETATM 7460 O O   . HOH V 7 .   ? -9.954  -5.337  29.508  1.00 24.78 ?  973  HOH B O   1 
HETATM 7461 O O   . HOH V 7 .   ? -27.821 -22.463 24.300  1.00 18.50 ?  974  HOH B O   1 
HETATM 7462 O O   . HOH V 7 .   ? -16.203 -13.843 43.102  1.00 40.61 ?  975  HOH B O   1 
HETATM 7463 O O   . HOH V 7 .   ? -37.129 -42.283 9.379   1.00 32.87 ?  976  HOH B O   1 
HETATM 7464 O O   . HOH V 7 .   ? 4.054   -31.109 22.511  1.00 28.50 ?  977  HOH B O   1 
HETATM 7465 O O   . HOH V 7 .   ? 14.562  -8.276  26.274  1.00 28.32 ?  978  HOH B O   1 
HETATM 7466 O O   . HOH V 7 .   ? 4.355   -10.166 12.312  1.00 35.51 ?  979  HOH B O   1 
HETATM 7467 O O   . HOH V 7 .   ? -39.303 -43.052 30.379  1.00 36.50 ?  980  HOH B O   1 
HETATM 7468 O O   . HOH V 7 .   ? 0.365   -13.161 47.031  1.00 38.19 ?  981  HOH B O   1 
HETATM 7469 O O   . HOH V 7 .   ? -38.364 -37.978 28.995  1.00 30.76 ?  982  HOH B O   1 
HETATM 7470 O O   . HOH V 7 .   ? 6.356   -10.991 13.712  1.00 27.46 ?  983  HOH B O   1 
HETATM 7471 O O   . HOH V 7 .   ? -5.667  -17.565 1.100   1.00 33.58 ?  984  HOH B O   1 
HETATM 7472 O O   . HOH V 7 .   ? -3.177  -30.435 12.409  1.00 24.19 ?  985  HOH B O   1 
HETATM 7473 O O   . HOH V 7 .   ? 5.070   -34.253 38.441  1.00 31.14 ?  986  HOH B O   1 
HETATM 7474 O O   . HOH V 7 .   ? -25.403 -21.709 30.946  1.00 31.68 ?  987  HOH B O   1 
HETATM 7475 O O   . HOH V 7 .   ? -8.683  -5.148  34.367  1.00 27.10 ?  988  HOH B O   1 
HETATM 7476 O O   . HOH V 7 .   ? 15.920  -19.585 34.808  1.00 41.18 ?  989  HOH B O   1 
HETATM 7477 O O   . HOH V 7 .   ? -37.532 -40.829 29.028  1.00 26.06 ?  990  HOH B O   1 
HETATM 7478 O O   . HOH V 7 .   ? -40.240 -47.246 30.081  1.00 24.74 ?  991  HOH B O   1 
HETATM 7479 O O   . HOH V 7 .   ? 12.513  -9.710  23.506  1.00 28.31 ?  992  HOH B O   1 
HETATM 7480 O O   . HOH V 7 .   ? -12.078 -7.508  30.139  1.00 19.54 ?  993  HOH B O   1 
HETATM 7481 O O   . HOH V 7 .   ? 2.460   -24.338 42.377  1.00 22.50 ?  994  HOH B O   1 
HETATM 7482 O O   . HOH V 7 .   ? -7.263  -5.977  18.237  1.00 32.42 ?  995  HOH B O   1 
HETATM 7483 O O   . HOH V 7 .   ? -35.880 -38.886 29.599  1.00 31.69 ?  996  HOH B O   1 
HETATM 7484 O O   . HOH V 7 .   ? 9.779   -6.502  39.012  1.00 39.34 ?  997  HOH B O   1 
HETATM 7485 O O   . HOH V 7 .   ? 0.531   -23.378 44.272  1.00 34.68 ?  998  HOH B O   1 
HETATM 7486 O O   . HOH V 7 .   ? -14.470 -6.725  29.915  1.00 21.26 ?  999  HOH B O   1 
HETATM 7487 O O   . HOH V 7 .   ? -34.833 -10.640 21.299  1.00 35.97 ?  1000 HOH B O   1 
HETATM 7488 O O   . HOH V 7 .   ? -17.351 -7.533  33.610  1.00 32.85 ?  1001 HOH B O   1 
HETATM 7489 O O   . HOH V 7 .   ? -9.816  -4.797  17.874  1.00 28.27 ?  1002 HOH B O   1 
HETATM 7490 O O   . HOH V 7 .   ? -12.190 -7.168  32.859  1.00 24.65 ?  1003 HOH B O   1 
HETATM 7491 O O   . HOH V 7 .   ? -14.758 -7.138  34.176  1.00 35.05 ?  1004 HOH B O   1 
HETATM 7492 O O   . HOH V 7 .   ? -35.593 -8.734  19.321  1.00 42.42 ?  1005 HOH B O   1 
HETATM 7493 O O   . HOH W 7 .   ? -21.752 -32.099 -28.361 1.00 32.30 ?  301  HOH D O   1 
HETATM 7494 O O   . HOH W 7 .   ? -29.979 -22.985 2.208   1.00 21.97 ?  302  HOH D O   1 
HETATM 7495 O O   . HOH W 7 .   ? -15.467 -14.260 -15.762 1.00 19.30 ?  303  HOH D O   1 
HETATM 7496 O O   . HOH W 7 .   ? -12.625 -34.349 -11.478 1.00 22.97 ?  304  HOH D O   1 
HETATM 7497 O O   . HOH W 7 .   ? -32.161 -30.380 -16.182 1.00 25.15 ?  305  HOH D O   1 
HETATM 7498 O O   . HOH W 7 .   ? -11.482 -19.633 -22.961 1.00 33.05 ?  306  HOH D O   1 
HETATM 7499 O O   . HOH W 7 .   ? -26.712 -25.386 -2.793  1.00 8.49  ?  307  HOH D O   1 
HETATM 7500 O O   . HOH W 7 .   ? -2.538  -25.358 -11.456 1.00 10.83 ?  308  HOH D O   1 
HETATM 7501 O O   . HOH W 7 .   ? -34.790 -14.462 4.695   1.00 33.19 ?  309  HOH D O   1 
HETATM 7502 O O   . HOH W 7 .   ? -21.901 -6.049  -9.744  1.00 27.88 ?  310  HOH D O   1 
HETATM 7503 O O   . HOH W 7 .   ? -27.263 -10.283 2.240   1.00 25.31 ?  311  HOH D O   1 
HETATM 7504 O O   . HOH W 7 .   ? -24.278 -6.579  -6.768  1.00 23.78 ?  312  HOH D O   1 
HETATM 7505 O O   . HOH W 7 .   ? -31.223 -13.278 4.909   1.00 37.26 ?  313  HOH D O   1 
HETATM 7506 O O   . HOH W 7 .   ? -13.636 -23.857 -23.589 1.00 23.99 ?  314  HOH D O   1 
HETATM 7507 O O   . HOH W 7 .   ? -12.096 -11.223 -7.596  1.00 32.19 ?  315  HOH D O   1 
HETATM 7508 O O   . HOH W 7 .   ? -18.612 -13.044 -15.663 1.00 22.69 ?  316  HOH D O   1 
HETATM 7509 O O   . HOH W 7 .   ? -35.397 -15.501 -8.951  1.00 26.80 ?  317  HOH D O   1 
HETATM 7510 O O   . HOH W 7 .   ? -32.488 -9.291  -16.297 1.00 32.75 ?  318  HOH D O   1 
HETATM 7511 O O   . HOH W 7 .   ? -32.793 -26.531 -3.663  1.00 21.80 ?  319  HOH D O   1 
HETATM 7512 O O   . HOH W 7 .   ? -6.819  -27.058 -7.763  1.00 17.15 ?  320  HOH D O   1 
HETATM 7513 O O   . HOH W 7 .   ? -15.226 -33.395 -8.562  1.00 18.06 ?  321  HOH D O   1 
HETATM 7514 O O   . HOH W 7 .   ? -9.604  -13.635 -11.054 1.00 32.51 ?  322  HOH D O   1 
HETATM 7515 O O   . HOH W 7 .   ? -28.034 -36.947 -9.030  1.00 25.01 ?  323  HOH D O   1 
HETATM 7516 O O   . HOH W 7 .   ? -12.556 -12.093 3.931   1.00 27.19 ?  324  HOH D O   1 
HETATM 7517 O O   . HOH W 7 .   ? -13.600 -14.817 7.037   1.00 19.91 ?  325  HOH D O   1 
HETATM 7518 O O   . HOH W 7 .   ? -29.578 -22.531 -16.897 1.00 24.10 ?  326  HOH D O   1 
HETATM 7519 O O   . HOH W 7 .   ? -12.560 -16.114 2.492   1.00 11.75 ?  327  HOH D O   1 
HETATM 7520 O O   . HOH W 7 .   ? -25.159 -14.333 -17.596 1.00 24.75 ?  328  HOH D O   1 
HETATM 7521 O O   . HOH W 7 .   ? -13.984 -30.259 0.729   1.00 15.34 ?  329  HOH D O   1 
HETATM 7522 O O   . HOH W 7 .   ? -23.435 -39.653 -13.408 1.00 16.53 ?  330  HOH D O   1 
HETATM 7523 O O   . HOH W 7 .   ? -7.598  -25.774 -16.613 1.00 17.94 ?  331  HOH D O   1 
HETATM 7524 O O   . HOH W 7 .   ? -27.713 -33.022 -2.961  1.00 26.55 ?  332  HOH D O   1 
HETATM 7525 O O   . HOH W 7 .   ? -22.358 -24.615 2.995   1.00 12.38 ?  333  HOH D O   1 
HETATM 7526 O O   . HOH W 7 .   ? -12.873 -12.394 -5.258  1.00 23.27 ?  334  HOH D O   1 
HETATM 7527 O O   . HOH W 7 .   ? -22.148 -17.293 -16.849 1.00 14.78 ?  335  HOH D O   1 
HETATM 7528 O O   . HOH W 7 .   ? -3.427  -19.710 -15.412 1.00 22.05 ?  336  HOH D O   1 
HETATM 7529 O O   . HOH W 7 .   ? -28.032 -31.100 -0.679  1.00 17.09 ?  337  HOH D O   1 
HETATM 7530 O O   . HOH W 7 .   ? -17.199 -40.613 -8.383  1.00 34.60 ?  338  HOH D O   1 
HETATM 7531 O O   . HOH W 7 .   ? -24.346 -38.130 -8.554  1.00 21.26 ?  339  HOH D O   1 
HETATM 7532 O O   . HOH W 7 .   ? -17.513 -20.337 -20.241 1.00 16.82 ?  340  HOH D O   1 
HETATM 7533 O O   . HOH W 7 .   ? -15.335 -6.774  -6.429  1.00 24.77 ?  341  HOH D O   1 
HETATM 7534 O O   . HOH W 7 .   ? -25.035 -33.359 -25.581 1.00 21.02 ?  342  HOH D O   1 
HETATM 7535 O O   . HOH W 7 .   ? -23.329 -10.504 2.538   1.00 31.31 ?  343  HOH D O   1 
HETATM 7536 O O   . HOH W 7 .   ? -18.511 -32.552 -28.666 1.00 36.25 ?  344  HOH D O   1 
HETATM 7537 O O   . HOH W 7 .   ? -15.420 -28.876 -27.683 1.00 30.72 ?  345  HOH D O   1 
HETATM 7538 O O   . HOH W 7 .   ? -23.229 -34.368 -3.170  1.00 15.65 ?  346  HOH D O   1 
HETATM 7539 O O   . HOH W 7 .   ? -31.834 -30.262 -11.728 1.00 25.91 ?  347  HOH D O   1 
HETATM 7540 O O   . HOH W 7 .   ? -25.598 -21.010 -22.895 1.00 31.57 ?  348  HOH D O   1 
HETATM 7541 O O   . HOH W 7 .   ? -10.759 -14.051 -4.399  1.00 27.32 ?  349  HOH D O   1 
HETATM 7542 O O   . HOH W 7 .   ? -17.144 -37.809 -11.662 1.00 20.83 ?  350  HOH D O   1 
HETATM 7543 O O   . HOH W 7 .   ? -15.544 -9.215  6.607   1.00 32.92 ?  351  HOH D O   1 
HETATM 7544 O O   . HOH W 7 .   ? -30.100 -13.003 -17.180 1.00 34.94 ?  352  HOH D O   1 
HETATM 7545 O O   . HOH W 7 .   ? -30.528 -7.821  -6.478  1.00 31.95 ?  353  HOH D O   1 
HETATM 7546 O O   . HOH W 7 .   ? -34.187 -17.766 -11.462 1.00 26.71 ?  354  HOH D O   1 
HETATM 7547 O O   . HOH W 7 .   ? -23.097 -8.541  -13.212 1.00 26.60 ?  355  HOH D O   1 
HETATM 7548 O O   . HOH W 7 .   ? -18.012 -14.923 7.216   1.00 15.25 ?  356  HOH D O   1 
HETATM 7549 O O   . HOH W 7 .   ? -12.417 -30.947 -14.167 1.00 16.81 ?  357  HOH D O   1 
HETATM 7550 O O   . HOH W 7 .   ? -13.767 -32.749 -23.863 1.00 32.00 ?  358  HOH D O   1 
HETATM 7551 O O   . HOH W 7 .   ? -32.850 -22.481 -10.739 1.00 21.40 ?  359  HOH D O   1 
HETATM 7552 O O   . HOH W 7 .   ? -34.355 -19.659 -4.420  1.00 18.50 ?  360  HOH D O   1 
HETATM 7553 O O   . HOH W 7 .   ? -16.361 -33.564 -11.028 1.00 12.43 ?  361  HOH D O   1 
HETATM 7554 O O   . HOH W 7 .   ? -23.636 -12.135 5.465   1.00 29.17 ?  362  HOH D O   1 
HETATM 7555 O O   . HOH W 7 .   ? -22.401 -36.235 -5.085  1.00 20.35 ?  363  HOH D O   1 
HETATM 7556 O O   . HOH W 7 .   ? -31.766 -28.861 0.182   1.00 24.79 ?  364  HOH D O   1 
HETATM 7557 O O   . HOH W 7 .   ? -32.007 -28.187 -7.330  1.00 15.58 ?  365  HOH D O   1 
HETATM 7558 O O   . HOH W 7 .   ? -32.605 -19.470 -15.032 1.00 31.66 ?  366  HOH D O   1 
HETATM 7559 O O   . HOH W 7 .   ? -11.659 -29.763 -21.773 1.00 24.55 ?  367  HOH D O   1 
HETATM 7560 O O   . HOH W 7 .   ? -28.953 -26.168 -19.130 1.00 30.33 ?  368  HOH D O   1 
HETATM 7561 O O   . HOH W 7 .   ? -12.558 -33.625 -4.657  1.00 21.22 ?  369  HOH D O   1 
HETATM 7562 O O   . HOH W 7 .   ? -11.121 -26.380 -5.820  1.00 10.00 ?  370  HOH D O   1 
HETATM 7563 O O   . HOH W 7 .   ? -16.063 -34.192 -5.999  1.00 11.89 ?  371  HOH D O   1 
HETATM 7564 O O   . HOH W 7 .   ? -29.806 -32.680 -14.007 1.00 21.81 ?  372  HOH D O   1 
HETATM 7565 O O   . HOH W 7 .   ? -22.313 -33.942 0.833   1.00 34.12 ?  373  HOH D O   1 
HETATM 7566 O O   . HOH W 7 .   ? -32.982 -28.688 -14.398 1.00 18.73 ?  374  HOH D O   1 
HETATM 7567 O O   . HOH W 7 .   ? -11.897 -36.378 -3.133  1.00 21.70 ?  375  HOH D O   1 
HETATM 7568 O O   . HOH W 7 .   ? -19.220 -38.170 -1.859  1.00 33.55 ?  376  HOH D O   1 
HETATM 7569 O O   . HOH W 7 .   ? -26.755 -7.798  -12.170 1.00 26.76 ?  377  HOH D O   1 
HETATM 7570 O O   . HOH W 7 .   ? -7.421  -23.307 -8.064  1.00 18.29 ?  378  HOH D O   1 
HETATM 7571 O O   . HOH W 7 .   ? -31.885 -23.763 -15.865 1.00 30.72 ?  379  HOH D O   1 
HETATM 7572 O O   . HOH W 7 .   ? -22.222 -37.378 -10.014 1.00 16.40 ?  380  HOH D O   1 
HETATM 7573 O O   . HOH W 7 .   ? -27.642 -25.096 -21.233 1.00 22.48 ?  381  HOH D O   1 
HETATM 7574 O O   . HOH W 7 .   ? -25.250 -31.350 -0.046  1.00 18.37 ?  382  HOH D O   1 
HETATM 7575 O O   . HOH W 7 .   ? -36.426 -17.832 0.487   1.00 32.22 ?  383  HOH D O   1 
HETATM 7576 O O   . HOH W 7 .   ? -7.634  -32.873 -6.571  1.00 19.13 ?  384  HOH D O   1 
HETATM 7577 O O   . HOH W 7 .   ? -12.183 -26.617 -3.207  1.00 7.84  ?  385  HOH D O   1 
HETATM 7578 O O   . HOH W 7 .   ? -18.063 -26.560 -25.675 1.00 19.20 ?  386  HOH D O   1 
HETATM 7579 O O   . HOH W 7 .   ? -9.807  -25.712 -17.910 1.00 17.83 ?  387  HOH D O   1 
HETATM 7580 O O   . HOH W 7 .   ? -14.463 -16.852 -18.860 1.00 30.51 ?  388  HOH D O   1 
HETATM 7581 O O   . HOH W 7 .   ? -10.608 -37.812 1.313   1.00 15.34 ?  389  HOH D O   1 
HETATM 7582 O O   . HOH W 7 .   ? -30.408 -33.065 -11.187 1.00 16.86 ?  390  HOH D O   1 
HETATM 7583 O O   . HOH W 7 .   ? -24.428 -23.679 -23.457 1.00 27.09 ?  391  HOH D O   1 
HETATM 7584 O O   . HOH W 7 .   ? -36.344 -16.014 -6.402  1.00 24.63 ?  392  HOH D O   1 
HETATM 7585 O O   . HOH W 7 .   ? -23.652 -17.919 -20.800 1.00 28.48 ?  393  HOH D O   1 
HETATM 7586 O O   . HOH W 7 .   ? -11.503 -13.632 -13.975 1.00 27.38 ?  394  HOH D O   1 
HETATM 7587 O O   . HOH W 7 .   ? -22.207 -10.978 -14.048 1.00 17.39 ?  395  HOH D O   1 
HETATM 7588 O O   . HOH W 7 .   ? -30.855 -7.424  -3.992  1.00 21.25 ?  396  HOH D O   1 
HETATM 7589 O O   . HOH W 7 .   ? -19.225 -10.691 -14.106 1.00 25.58 ?  397  HOH D O   1 
HETATM 7590 O O   . HOH W 7 .   ? -30.863 -4.764  -3.123  1.00 33.22 ?  398  HOH D O   1 
HETATM 7591 O O   . HOH W 7 .   ? -18.483 -9.433  -2.444  1.00 17.94 ?  399  HOH D O   1 
HETATM 7592 O O   . HOH W 7 .   ? -19.474 -19.345 -23.566 1.00 31.97 ?  400  HOH D O   1 
HETATM 7593 O O   . HOH W 7 .   ? -13.336 -10.106 -12.864 1.00 20.48 ?  401  HOH D O   1 
HETATM 7594 O O   . HOH W 7 .   ? -34.151 -29.435 -7.285  1.00 35.43 ?  402  HOH D O   1 
HETATM 7595 O O   . HOH W 7 .   ? -31.979 -23.912 0.306   1.00 20.85 ?  403  HOH D O   1 
HETATM 7596 O O   . HOH W 7 .   ? -16.816 -9.848  1.898   1.00 36.16 ?  404  HOH D O   1 
HETATM 7597 O O   . HOH W 7 .   ? -17.292 -6.445  -4.588  1.00 27.41 ?  405  HOH D O   1 
HETATM 7598 O O   . HOH W 7 .   ? -9.217  -17.081 -11.902 1.00 18.52 ?  406  HOH D O   1 
HETATM 7599 O O   . HOH W 7 .   ? -28.235 -4.345  -8.469  1.00 35.28 ?  407  HOH D O   1 
HETATM 7600 O O   . HOH W 7 .   ? -29.842 -33.292 -7.290  1.00 27.18 ?  408  HOH D O   1 
HETATM 7601 O O   . HOH W 7 .   ? -19.102 -17.338 -21.292 1.00 35.76 ?  409  HOH D O   1 
HETATM 7602 O O   . HOH W 7 .   ? -20.913 -39.736 -1.776  1.00 38.60 ?  410  HOH D O   1 
HETATM 7603 O O   . HOH W 7 .   ? -11.967 -29.008 -1.847  1.00 9.62  ?  411  HOH D O   1 
HETATM 7604 O O   . HOH W 7 .   ? -19.311 -11.331 6.729   1.00 20.51 ?  412  HOH D O   1 
HETATM 7605 O O   . HOH W 7 .   ? -19.726 -33.832 1.986   1.00 31.80 ?  413  HOH D O   1 
HETATM 7606 O O   . HOH W 7 .   ? -17.149 -35.787 1.923   1.00 27.48 ?  414  HOH D O   1 
HETATM 7607 O O   . HOH W 7 .   ? -25.642 -16.407 -19.528 1.00 33.83 ?  415  HOH D O   1 
HETATM 7608 O O   . HOH W 7 .   ? -11.847 -34.898 -6.915  1.00 34.64 ?  416  HOH D O   1 
HETATM 7609 O O   . HOH W 7 .   ? -10.764 -23.786 -23.276 1.00 22.90 ?  417  HOH D O   1 
HETATM 7610 O O   . HOH W 7 .   ? -37.688 -21.960 7.790   1.00 39.03 ?  418  HOH D O   1 
HETATM 7611 O O   . HOH W 7 .   ? -6.479  -32.789 -17.588 1.00 27.87 ?  419  HOH D O   1 
HETATM 7612 O O   . HOH W 7 .   ? -21.910 -31.628 4.525   1.00 26.27 ?  420  HOH D O   1 
HETATM 7613 O O   . HOH W 7 .   ? -40.282 -23.648 1.862   1.00 33.44 ?  421  HOH D O   1 
HETATM 7614 O O   . HOH W 7 .   ? -12.408 -8.094  -6.031  1.00 39.25 ?  422  HOH D O   1 
HETATM 7615 O O   . HOH W 7 .   ? -21.466 -37.622 -2.662  1.00 34.68 ?  423  HOH D O   1 
HETATM 7616 O O   . HOH W 7 .   ? -33.089 -16.858 -14.628 1.00 33.96 ?  424  HOH D O   1 
HETATM 7617 O O   . HOH W 7 .   ? -38.532 -25.828 2.434   1.00 36.49 ?  425  HOH D O   1 
HETATM 7618 O O   . HOH W 7 .   ? -32.299 -28.235 -18.716 1.00 34.95 ?  426  HOH D O   1 
HETATM 7619 O O   . HOH W 7 .   ? -35.548 -24.139 -10.574 1.00 29.10 ?  427  HOH D O   1 
HETATM 7620 O O   . HOH W 7 .   ? -16.710 -24.382 -26.781 1.00 38.87 ?  428  HOH D O   1 
HETATM 7621 O O   . HOH W 7 .   ? -33.896 -27.263 -1.036  1.00 31.17 ?  429  HOH D O   1 
HETATM 7622 O O   . HOH W 7 .   ? -29.552 -22.914 -21.148 1.00 40.97 ?  430  HOH D O   1 
HETATM 7623 O O   . HOH W 7 .   ? -25.123 -40.586 -9.229  1.00 32.99 ?  431  HOH D O   1 
HETATM 7624 O O   . HOH W 7 .   ? -21.743 -39.816 -11.240 1.00 21.20 ?  432  HOH D O   1 
HETATM 7625 O O   . HOH W 7 .   ? -12.232 -10.997 -3.499  1.00 37.58 ?  433  HOH D O   1 
HETATM 7626 O O   . HOH W 7 .   ? -17.754 -12.675 8.641   1.00 16.91 ?  434  HOH D O   1 
HETATM 7627 O O   . HOH W 7 .   ? -21.621 -16.714 -19.470 1.00 21.98 ?  435  HOH D O   1 
HETATM 7628 O O   . HOH W 7 .   ? -12.935 -35.501 -23.315 1.00 35.42 ?  436  HOH D O   1 
HETATM 7629 O O   . HOH W 7 .   ? -19.026 -39.908 -11.442 1.00 33.66 ?  437  HOH D O   1 
HETATM 7630 O O   . HOH W 7 .   ? -24.272 -37.874 -5.816  1.00 25.24 ?  438  HOH D O   1 
HETATM 7631 O O   . HOH W 7 .   ? -30.495 -35.900 -10.614 1.00 26.63 ?  439  HOH D O   1 
HETATM 7632 O O   . HOH W 7 .   ? -31.951 -25.317 -18.733 1.00 38.36 ?  440  HOH D O   1 
HETATM 7633 O O   . HOH W 7 .   ? -21.055 -12.945 5.741   1.00 20.15 ?  441  HOH D O   1 
HETATM 7634 O O   . HOH W 7 .   ? -9.686  -15.672 -14.200 1.00 30.04 ?  442  HOH D O   1 
HETATM 7635 O O   . HOH W 7 .   ? -24.015 -40.253 -4.563  1.00 41.58 ?  443  HOH D O   1 
HETATM 7636 O O   . HOH W 7 .   ? -20.168 -43.405 -9.039  1.00 42.46 ?  444  HOH D O   1 
HETATM 7637 O O   . HOH W 7 .   ? -14.755 -38.917 -9.903  1.00 46.32 ?  445  HOH D O   1 
HETATM 7638 O O   . HOH W 7 .   ? -22.782 -42.055 -10.211 1.00 34.27 ?  446  HOH D O   1 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   THR 1   224 224 THR THR A . n 
A 1 2   LYS 2   225 225 LYS LYS A . n 
A 1 3   PRO 3   226 226 PRO PRO A . n 
A 1 4   PHE 4   227 227 PHE PHE A . n 
A 1 5   SER 5   228 228 SER SER A . n 
A 1 6   VAL 6   229 229 VAL VAL A . n 
A 1 7   PRO 7   230 230 PRO PRO A . n 
A 1 8   VAL 8   231 231 VAL VAL A . n 
A 1 9   LEU 9   232 232 LEU LEU A . n 
A 1 10  THR 10  233 233 THR THR A . n 
A 1 11  VAL 11  234 234 VAL VAL A . n 
A 1 12  GLU 12  235 235 GLU GLU A . n 
A 1 13  GLU 13  236 236 GLU GLU A . n 
A 1 14  MET 14  237 237 MET MET A . n 
A 1 15  THR 15  238 238 THR THR A . n 
A 1 16  ASN 16  239 239 ASN ASN A . n 
A 1 17  SER 17  240 240 SER SER A . n 
A 1 18  ARG 18  241 241 ARG ARG A . n 
A 1 19  PHE 19  242 242 PHE PHE A . n 
A 1 20  PRO 20  243 243 PRO PRO A . n 
A 1 21  ILE 21  244 244 ILE ILE A . n 
A 1 22  PRO 22  245 245 PRO PRO A . n 
A 1 23  LEU 23  246 246 LEU LEU A . n 
A 1 24  GLU 24  247 247 GLU GLU A . n 
A 1 25  LYS 25  248 248 LYS LYS A . n 
A 1 26  LEU 26  249 249 LEU LEU A . n 
A 1 27  PHE 27  250 250 PHE PHE A . n 
A 1 28  THR 28  251 251 THR THR A . n 
A 1 29  GLY 29  252 252 GLY GLY A . n 
A 1 30  PRO 30  253 253 PRO PRO A . n 
A 1 31  SER 31  254 254 SER SER A . n 
A 1 32  SER 32  255 255 SER SER A . n 
A 1 33  ALA 33  256 256 ALA ALA A . n 
A 1 34  PHE 34  257 257 PHE PHE A . n 
A 1 35  VAL 35  258 258 VAL VAL A . n 
A 1 36  VAL 36  259 259 VAL VAL A . n 
A 1 37  GLN 37  260 260 GLN GLN A . n 
A 1 38  PRO 38  261 261 PRO PRO A . n 
A 1 39  GLN 39  262 262 GLN GLN A . n 
A 1 40  ASN 40  263 263 ASN ASN A . n 
A 1 41  GLY 41  264 264 GLY GLY A . n 
A 1 42  ARG 42  265 265 ARG ARG A . n 
A 1 43  CYS 43  266 266 CYS CYS A . n 
A 1 44  THR 44  267 267 THR THR A . n 
A 1 45  THR 45  268 268 THR THR A . n 
A 1 46  ASP 46  269 269 ASP ASP A . n 
A 1 47  GLY 47  270 270 GLY GLY A . n 
A 1 48  VAL 48  271 271 VAL VAL A . n 
A 1 49  LEU 49  272 272 LEU LEU A . n 
A 1 50  LEU 50  273 273 LEU LEU A . n 
A 1 51  GLY 51  274 274 GLY GLY A . n 
A 1 52  THR 52  275 275 THR THR A . n 
A 1 53  THR 53  276 276 THR THR A . n 
A 1 54  GLN 54  277 277 GLN GLN A . n 
A 1 55  LEU 55  278 278 LEU LEU A . n 
A 1 56  SER 56  279 279 SER SER A . n 
A 1 57  PRO 57  280 280 PRO PRO A . n 
A 1 58  VAL 58  281 281 VAL VAL A . n 
A 1 59  ASN 59  282 282 ASN ASN A . n 
A 1 60  ILE 60  283 283 ILE ILE A . n 
A 1 61  CYS 61  284 284 CYS CYS A . n 
A 1 62  THR 62  285 285 THR THR A . n 
A 1 63  PHE 63  286 286 PHE PHE A . n 
A 1 64  ARG 64  287 287 ARG ARG A . n 
A 1 65  GLY 65  288 288 GLY GLY A . n 
A 1 66  ASP 66  289 289 ASP ASP A . n 
A 1 67  VAL 67  290 290 VAL VAL A . n 
A 1 68  THR 68  291 291 THR THR A . n 
A 1 69  HIS 69  292 292 HIS HIS A . n 
A 1 70  ILE 70  293 293 ILE ILE A . n 
A 1 71  THR 71  294 294 THR THR A . n 
A 1 72  GLY 72  295 295 GLY GLY A . n 
A 1 73  SER 73  296 296 SER SER A . n 
A 1 74  ARG 74  297 297 ARG ARG A . n 
A 1 75  ASN 75  298 298 ASN ASN A . n 
A 1 76  TYR 76  299 299 TYR TYR A . n 
A 1 77  THR 77  300 300 THR THR A . n 
A 1 78  MET 78  301 301 MET MET A . n 
A 1 79  ASN 79  302 302 ASN ASN A . n 
A 1 80  LEU 80  303 303 LEU LEU A . n 
A 1 81  ALA 81  304 304 ALA ALA A . n 
A 1 82  SER 82  305 305 SER SER A . n 
A 1 83  GLN 83  306 306 GLN GLN A . n 
A 1 84  ASN 84  307 307 ASN ASN A . n 
A 1 85  TRP 85  308 308 TRP TRP A . n 
A 1 86  ASN 86  309 309 ASN ASN A . n 
A 1 87  ASP 87  310 310 ASP ASP A . n 
A 1 88  TYR 88  311 311 TYR TYR A . n 
A 1 89  ASP 89  312 312 ASP ASP A . n 
A 1 90  PRO 90  313 313 PRO PRO A . n 
A 1 91  THR 91  314 314 THR THR A . n 
A 1 92  GLU 92  315 315 GLU GLU A . n 
A 1 93  GLU 93  316 316 GLU GLU A . n 
A 1 94  ILE 94  317 317 ILE ILE A . n 
A 1 95  PRO 95  318 318 PRO PRO A . n 
A 1 96  ALA 96  319 319 ALA ALA A . n 
A 1 97  PRO 97  320 320 PRO PRO A . n 
A 1 98  LEU 98  321 321 LEU LEU A . n 
A 1 99  GLY 99  322 322 GLY GLY A . n 
A 1 100 THR 100 323 323 THR THR A . n 
A 1 101 PRO 101 324 324 PRO PRO A . n 
A 1 102 ASP 102 325 325 ASP ASP A . n 
A 1 103 PHE 103 326 326 PHE PHE A . n 
A 1 104 VAL 104 327 327 VAL VAL A . n 
A 1 105 GLY 105 328 328 GLY GLY A . n 
A 1 106 LYS 106 329 329 LYS LYS A . n 
A 1 107 ILE 107 330 330 ILE ILE A . n 
A 1 108 GLN 108 331 331 GLN GLN A . n 
A 1 109 GLY 109 332 332 GLY GLY A . n 
A 1 110 VAL 110 333 333 VAL VAL A . n 
A 1 111 LEU 111 334 334 LEU LEU A . n 
A 1 112 THR 112 335 335 THR THR A . n 
A 1 113 GLN 113 336 336 GLN GLN A . n 
A 1 114 THR 114 337 337 THR THR A . n 
A 1 115 THR 115 338 338 THR THR A . n 
A 1 116 ARG 116 339 339 ARG ARG A . n 
A 1 117 THR 117 340 340 THR THR A . n 
A 1 118 ASP 118 341 341 ASP ASP A . n 
A 1 119 GLY 119 342 342 GLY GLY A . n 
A 1 120 SER 120 343 343 SER SER A . n 
A 1 121 THR 121 344 344 THR THR A . n 
A 1 122 ARG 122 345 345 ARG ARG A . n 
A 1 123 GLY 123 346 346 GLY GLY A . n 
A 1 124 HIS 124 347 347 HIS HIS A . n 
A 1 125 LYS 125 348 348 LYS LYS A . n 
A 1 126 ALA 126 349 349 ALA ALA A . n 
A 1 127 THR 127 350 350 THR THR A . n 
A 1 128 VAL 128 351 351 VAL VAL A . n 
A 1 129 TYR 129 352 352 TYR TYR A . n 
A 1 130 THR 130 353 353 THR THR A . n 
A 1 131 GLY 131 354 354 GLY GLY A . n 
A 1 132 SER 132 355 355 SER SER A . n 
A 1 133 ALA 133 356 356 ALA ALA A . n 
A 1 134 ASP 134 357 357 ASP ASP A . n 
A 1 135 PHE 135 358 358 PHE PHE A . n 
A 1 136 ALA 136 359 359 ALA ALA A . n 
A 1 137 PRO 137 360 360 PRO PRO A . n 
A 1 138 LYS 138 361 361 LYS LYS A . n 
A 1 139 LEU 139 362 362 LEU LEU A . n 
A 1 140 GLY 140 363 363 GLY GLY A . n 
A 1 141 ARG 141 364 364 ARG ARG A . n 
A 1 142 VAL 142 365 365 VAL VAL A . n 
A 1 143 GLN 143 366 366 GLN GLN A . n 
A 1 144 PHE 144 367 367 PHE PHE A . n 
A 1 145 GLU 145 368 368 GLU GLU A . n 
A 1 146 THR 146 369 369 THR THR A . n 
A 1 147 ASP 147 370 370 ASP ASP A . n 
A 1 148 THR 148 371 371 THR THR A . n 
A 1 149 ASP 149 372 372 ASP ASP A . n 
A 1 150 ARG 150 373 373 ARG ARG A . n 
A 1 151 ASP 151 374 374 ASP ASP A . n 
A 1 152 PHE 152 375 375 PHE PHE A . n 
A 1 153 GLU 153 376 376 GLU GLU A . n 
A 1 154 ALA 154 377 377 ALA ALA A . n 
A 1 155 ASN 155 378 378 ASN ASN A . n 
A 1 156 GLN 156 379 379 GLN GLN A . n 
A 1 157 ASN 157 380 380 ASN ASN A . n 
A 1 158 THR 158 381 381 THR THR A . n 
A 1 159 LYS 159 382 382 LYS LYS A . n 
A 1 160 PHE 160 383 383 PHE PHE A . n 
A 1 161 THR 161 384 384 THR THR A . n 
A 1 162 PRO 162 385 385 PRO PRO A . n 
A 1 163 VAL 163 386 386 VAL VAL A . n 
A 1 164 GLY 164 387 387 GLY GLY A . n 
A 1 165 VAL 165 388 388 VAL VAL A . n 
A 1 166 ILE 166 389 389 ILE ILE A . n 
A 1 167 GLN 167 390 390 GLN GLN A . n 
A 1 168 ASP 168 391 391 ASP ASP A . n 
A 1 169 GLY 169 392 392 GLY GLY A . n 
A 1 170 GLY 170 393 393 GLY GLY A . n 
A 1 171 THR 171 394 394 THR THR A . n 
A 1 172 THR 172 395 395 THR THR A . n 
A 1 173 HIS 173 396 396 HIS HIS A . n 
A 1 174 ARG 174 397 397 ARG ARG A . n 
A 1 175 ASN 175 398 398 ASN ASN A . n 
A 1 176 GLU 176 399 399 GLU GLU A . n 
A 1 177 PRO 177 400 400 PRO PRO A . n 
A 1 178 GLN 178 401 401 GLN GLN A . n 
A 1 179 GLN 179 402 402 GLN GLN A . n 
A 1 180 TRP 180 403 403 TRP TRP A . n 
A 1 181 VAL 181 404 404 VAL VAL A . n 
A 1 182 LEU 182 405 405 LEU LEU A . n 
A 1 183 PRO 183 406 406 PRO PRO A . n 
A 1 184 SER 184 407 407 SER SER A . n 
A 1 185 TYR 185 408 408 TYR TYR A . n 
A 1 186 SER 186 409 409 SER SER A . n 
A 1 187 GLY 187 410 410 GLY GLY A . n 
A 1 188 ARG 188 411 411 ARG ARG A . n 
A 1 189 ASN 189 412 412 ASN ASN A . n 
A 1 190 THR 190 413 413 THR THR A . n 
A 1 191 HIS 191 414 414 HIS HIS A . n 
A 1 192 ASN 192 415 415 ASN ASN A . n 
A 1 193 VAL 193 416 416 VAL VAL A . n 
A 1 194 HIS 194 417 417 HIS HIS A . n 
A 1 195 LEU 195 418 418 LEU LEU A . n 
A 1 196 ALA 196 419 419 ALA ALA A . n 
A 1 197 PRO 197 420 420 PRO PRO A . n 
A 1 198 ALA 198 421 421 ALA ALA A . n 
A 1 199 VAL 199 422 422 VAL VAL A . n 
A 1 200 ALA 200 423 423 ALA ALA A . n 
A 1 201 PRO 201 424 424 PRO PRO A . n 
A 1 202 THR 202 425 425 THR THR A . n 
A 1 203 PHE 203 426 426 PHE PHE A . n 
A 1 204 PRO 204 427 427 PRO PRO A . n 
A 1 205 GLY 205 428 428 GLY GLY A . n 
A 1 206 GLU 206 429 429 GLU GLU A . n 
A 1 207 GLN 207 430 430 GLN GLN A . n 
A 1 208 LEU 208 431 431 LEU LEU A . n 
A 1 209 LEU 209 432 432 LEU LEU A . n 
A 1 210 PHE 210 433 433 PHE PHE A . n 
A 1 211 PHE 211 434 434 PHE PHE A . n 
A 1 212 ARG 212 435 435 ARG ARG A . n 
A 1 213 SER 213 436 436 SER SER A . n 
A 1 214 THR 214 437 437 THR THR A . n 
A 1 215 MET 215 438 438 MET MET A . n 
A 1 216 PRO 216 439 439 PRO PRO A . n 
A 1 217 GLY 217 440 440 GLY GLY A . n 
A 1 218 CYS 218 441 441 CYS CYS A . n 
A 1 219 SER 219 442 442 SER SER A . n 
A 1 220 GLY 220 443 443 GLY GLY A . n 
A 1 221 TYR 221 444 444 TYR TYR A . n 
A 1 222 PRO 222 445 445 PRO PRO A . n 
A 1 223 ASN 223 446 446 ASN ASN A . n 
A 1 224 MET 224 447 447 MET MET A . n 
A 1 225 ASP 225 448 448 ASP ASP A . n 
A 1 226 LEU 226 449 449 LEU LEU A . n 
A 1 227 ASP 227 450 450 ASP ASP A . n 
A 1 228 CYS 228 451 451 CYS CYS A . n 
A 1 229 LEU 229 452 452 LEU LEU A . n 
A 1 230 LEU 230 453 453 LEU LEU A . n 
A 1 231 PRO 231 454 454 PRO PRO A . n 
A 1 232 GLN 232 455 455 GLN GLN A . n 
A 1 233 GLU 233 456 456 GLU GLU A . n 
A 1 234 TRP 234 457 457 TRP TRP A . n 
A 1 235 VAL 235 458 458 VAL VAL A . n 
A 1 236 GLN 236 459 459 GLN GLN A . n 
A 1 237 TYR 237 460 460 TYR TYR A . n 
A 1 238 PHE 238 461 461 PHE PHE A . n 
A 1 239 TYR 239 462 462 TYR TYR A . n 
A 1 240 GLN 240 463 463 GLN GLN A . n 
A 1 241 GLU 241 464 464 GLU GLU A . n 
A 1 242 ALA 242 465 465 ALA ALA A . n 
A 1 243 ALA 243 466 466 ALA ALA A . n 
A 1 244 PRO 244 467 467 PRO PRO A . n 
A 1 245 ALA 245 468 468 ALA ALA A . n 
A 1 246 GLN 246 469 469 GLN GLN A . n 
A 1 247 SER 247 470 470 SER SER A . n 
A 1 248 ASP 248 471 471 ASP ASP A . n 
A 1 249 VAL 249 472 472 VAL VAL A . n 
A 1 250 ALA 250 473 473 ALA ALA A . n 
A 1 251 LEU 251 474 474 LEU LEU A . n 
A 1 252 LEU 252 475 475 LEU LEU A . n 
A 1 253 ARG 253 476 476 ARG ARG A . n 
A 1 254 PHE 254 477 477 PHE PHE A . n 
A 1 255 VAL 255 478 478 VAL VAL A . n 
A 1 256 ASN 256 479 479 ASN ASN A . n 
A 1 257 PRO 257 480 480 PRO PRO A . n 
A 1 258 ASP 258 481 481 ASP ASP A . n 
A 1 259 THR 259 482 482 THR THR A . n 
A 1 260 GLY 260 483 483 GLY GLY A . n 
A 1 261 ARG 261 484 484 ARG ARG A . n 
A 1 262 VAL 262 485 485 VAL VAL A . n 
A 1 263 LEU 263 486 486 LEU LEU A . n 
A 1 264 PHE 264 487 487 PHE PHE A . n 
A 1 265 GLU 265 488 488 GLU GLU A . n 
A 1 266 CYS 266 489 489 CYS CYS A . n 
A 1 267 LYS 267 490 490 LYS LYS A . n 
A 1 268 LEU 268 491 491 LEU LEU A . n 
A 1 269 HIS 269 492 492 HIS HIS A . n 
A 1 270 LYS 270 493 493 LYS LYS A . n 
A 1 271 SER 271 494 494 SER SER A . n 
A 1 272 GLY 272 495 495 GLY GLY A . n 
A 1 273 TYR 273 496 496 TYR TYR A . n 
A 1 274 VAL 274 497 497 VAL VAL A . n 
A 1 275 THR 275 498 498 THR THR A . n 
A 1 276 VAL 276 499 499 VAL VAL A . n 
A 1 277 ALA 277 500 500 ALA ALA A . n 
A 1 278 HIS 278 501 501 HIS HIS A . n 
A 1 279 THR 279 502 502 THR THR A . n 
A 1 280 GLY 280 503 503 GLY GLY A . n 
A 1 281 GLN 281 504 504 GLN GLN A . n 
A 1 282 HIS 282 505 505 HIS HIS A . n 
A 1 283 ASP 283 506 506 ASP ASP A . n 
A 1 284 LEU 284 507 507 LEU LEU A . n 
A 1 285 VAL 285 508 508 VAL VAL A . n 
A 1 286 ILE 286 509 509 ILE ILE A . n 
A 1 287 PRO 287 510 510 PRO PRO A . n 
A 1 288 PRO 288 511 511 PRO PRO A . n 
A 1 289 ASN 289 512 512 ASN ASN A . n 
A 1 290 GLY 290 513 513 GLY GLY A . n 
A 1 291 TYR 291 514 514 TYR TYR A . n 
A 1 292 PHE 292 515 515 PHE PHE A . n 
A 1 293 ARG 293 516 516 ARG ARG A . n 
A 1 294 PHE 294 517 517 PHE PHE A . n 
A 1 295 ASP 295 518 518 ASP ASP A . n 
A 1 296 SER 296 519 519 SER SER A . n 
A 1 297 TRP 297 520 520 TRP TRP A . n 
A 1 298 VAL 298 521 521 VAL VAL A . n 
A 1 299 ASN 299 522 522 ASN ASN A . n 
A 1 300 GLN 300 523 523 GLN GLN A . n 
A 1 301 PHE 301 524 524 PHE PHE A . n 
A 1 302 TYR 302 525 525 TYR TYR A . n 
A 1 303 THR 303 526 526 THR THR A . n 
A 1 304 LEU 304 527 527 LEU LEU A . n 
A 1 305 ALA 305 528 528 ALA ALA A . n 
A 1 306 PRO 306 529 529 PRO PRO A . n 
A 1 307 MET 307 530 530 MET MET A . n 
B 2 1   GLN 1   1   1   GLN GLN C . n 
B 2 2   VAL 2   2   2   VAL VAL C . n 
B 2 3   GLN 3   3   3   GLN GLN C . n 
B 2 4   LEU 4   4   4   LEU LEU C . n 
B 2 5   GLN 5   5   5   GLN GLN C . n 
B 2 6   GLU 6   6   6   GLU GLU C . n 
B 2 7   SER 7   7   7   SER SER C . n 
B 2 8   GLY 8   8   8   GLY GLY C . n 
B 2 9   GLY 9   9   9   GLY GLY C . n 
B 2 10  GLY 10  10  10  GLY GLY C . n 
B 2 11  LEU 11  11  11  LEU LEU C . n 
B 2 12  VAL 12  12  12  VAL VAL C . n 
B 2 13  GLN 13  13  13  GLN GLN C . n 
B 2 14  ALA 14  14  14  ALA ALA C . n 
B 2 15  GLY 15  15  15  GLY GLY C . n 
B 2 16  GLY 16  16  16  GLY GLY C . n 
B 2 17  SER 17  17  17  SER SER C . n 
B 2 18  LEU 18  18  18  LEU LEU C . n 
B 2 19  ARG 19  19  19  ARG ARG C . n 
B 2 20  LEU 20  20  20  LEU LEU C . n 
B 2 21  SER 21  21  21  SER SER C . n 
B 2 22  CYS 22  22  22  CYS CYS C . n 
B 2 23  ALA 23  23  23  ALA ALA C . n 
B 2 24  ALA 24  24  24  ALA ALA C . n 
B 2 25  SER 25  25  25  SER SER C . n 
B 2 26  GLY 26  26  26  GLY GLY C . n 
B 2 27  THR 27  27  27  THR THR C . n 
B 2 28  ILE 28  28  28  ILE ILE C . n 
B 2 29  PHE 29  29  29  PHE PHE C . n 
B 2 30  SER 30  30  30  SER SER C . n 
B 2 31  ILE 31  31  31  ILE ILE C . n 
B 2 32  ASP 32  32  32  ASP ASP C . n 
B 2 33  ALA 33  33  33  ALA ALA C . n 
B 2 34  PHE 34  34  34  PHE PHE C . n 
B 2 35  GLY 35  35  35  GLY GLY C . n 
B 2 36  TRP 36  36  36  TRP TRP C . n 
B 2 37  TYR 37  37  37  TYR TYR C . n 
B 2 38  ARG 38  38  38  ARG ARG C . n 
B 2 39  GLN 39  39  39  GLN GLN C . n 
B 2 40  ALA 40  40  40  ALA ALA C . n 
B 2 41  PRO 41  41  41  PRO PRO C . n 
B 2 42  GLY 42  42  42  GLY GLY C . n 
B 2 43  LYS 43  43  43  LYS LYS C . n 
B 2 44  GLN 44  44  44  GLN GLN C . n 
B 2 45  ARG 45  45  45  ARG ARG C . n 
B 2 46  GLU 46  46  46  GLU GLU C . n 
B 2 47  TRP 47  47  47  TRP TRP C . n 
B 2 48  VAL 48  48  48  VAL VAL C . n 
B 2 49  ALA 49  49  49  ALA ALA C . n 
B 2 50  GLY 50  50  50  GLY GLY C . n 
B 2 51  ILE 51  51  51  ILE ILE C . n 
B 2 52  THR 52  52  52  THR THR C . n 
B 2 53  SER 53  53  53  SER SER C . n 
B 2 54  GLY 54  54  54  GLY GLY C . n 
B 2 55  SER 55  55  55  SER SER C . n 
B 2 56  SER 56  56  56  SER SER C . n 
B 2 57  THR 57  57  57  THR THR C . n 
B 2 58  ILE 58  58  58  ILE ILE C . n 
B 2 59  TYR 59  59  59  TYR TYR C . n 
B 2 60  ALA 60  60  60  ALA ALA C . n 
B 2 61  ASP 61  61  61  ASP ASP C . n 
B 2 62  PHE 62  62  62  PHE PHE C . n 
B 2 63  VAL 63  63  63  VAL VAL C . n 
B 2 64  LYS 64  64  64  LYS LYS C . n 
B 2 65  GLY 65  65  65  GLY GLY C . n 
B 2 66  ARG 66  66  66  ARG ARG C . n 
B 2 67  PHE 67  67  67  PHE PHE C . n 
B 2 68  THR 68  68  68  THR THR C . n 
B 2 69  ILE 69  69  69  ILE ILE C . n 
B 2 70  SER 70  70  70  SER SER C . n 
B 2 71  ARG 71  71  71  ARG ARG C . n 
B 2 72  ASP 72  72  72  ASP ASP C . n 
B 2 73  ASN 73  73  73  ASN ASN C . n 
B 2 74  ALA 74  74  74  ALA ALA C . n 
B 2 75  LYS 75  75  75  LYS LYS C . n 
B 2 76  ASN 76  76  76  ASN ASN C . n 
B 2 77  THR 77  77  77  THR THR C . n 
B 2 78  VAL 78  78  78  VAL VAL C . n 
B 2 79  PHE 79  79  79  PHE PHE C . n 
B 2 80  LEU 80  80  80  LEU LEU C . n 
B 2 81  GLN 81  81  81  GLN GLN C . n 
B 2 82  MET 82  82  82  MET MET C . n 
B 2 83  ASN 83  83  83  ASN ASN C . n 
B 2 84  SER 84  84  84  SER SER C . n 
B 2 85  LEU 85  85  85  LEU LEU C . n 
B 2 86  LYS 86  86  86  LYS LYS C . n 
B 2 87  PRO 87  87  87  PRO PRO C . n 
B 2 88  GLU 88  88  88  GLU GLU C . n 
B 2 89  ASP 89  89  89  ASP ASP C . n 
B 2 90  THR 90  90  90  THR THR C . n 
B 2 91  ALA 91  91  91  ALA ALA C . n 
B 2 92  VAL 92  92  92  VAL VAL C . n 
B 2 93  TYR 93  93  93  TYR TYR C . n 
B 2 94  TYR 94  94  94  TYR TYR C . n 
B 2 95  CYS 95  95  95  CYS CYS C . n 
B 2 96  ASN 96  96  96  ASN ASN C . n 
B 2 97  ARG 97  97  97  ARG ARG C . n 
B 2 98  ALA 98  98  98  ALA ALA C . n 
B 2 99  LYS 99  99  99  LYS LYS C . n 
B 2 100 PRO 100 100 100 PRO PRO C . n 
B 2 101 PRO 101 101 101 PRO PRO C . n 
B 2 102 THR 102 102 102 THR THR C . n 
B 2 103 TYR 103 103 103 TYR TYR C . n 
B 2 104 TYR 104 104 104 TYR TYR C . n 
B 2 105 SER 105 105 105 SER SER C . n 
B 2 106 LEU 106 106 106 LEU LEU C . n 
B 2 107 GLU 107 107 107 GLU GLU C . n 
B 2 108 PRO 108 108 108 PRO PRO C . n 
B 2 109 TRP 109 109 109 TRP TRP C . n 
B 2 110 GLY 110 110 110 GLY GLY C . n 
B 2 111 LYS 111 111 111 LYS LYS C . n 
B 2 112 GLY 112 112 112 GLY GLY C . n 
B 2 113 THR 113 113 113 THR THR C . n 
B 2 114 GLN 114 114 114 GLN GLN C . n 
B 2 115 VAL 115 115 115 VAL VAL C . n 
B 2 116 THR 116 116 116 THR THR C . n 
B 2 117 VAL 117 117 117 VAL VAL C . n 
B 2 118 SER 118 118 118 SER SER C . n 
B 2 119 SER 119 119 119 SER SER C . n 
B 2 120 HIS 120 120 120 HIS HIS C . n 
B 2 121 HIS 121 121 121 HIS HIS C . n 
C 1 1   THR 1   224 224 THR THR B . n 
C 1 2   LYS 2   225 225 LYS LYS B . n 
C 1 3   PRO 3   226 226 PRO PRO B . n 
C 1 4   PHE 4   227 227 PHE PHE B . n 
C 1 5   SER 5   228 228 SER SER B . n 
C 1 6   VAL 6   229 229 VAL VAL B . n 
C 1 7   PRO 7   230 230 PRO PRO B . n 
C 1 8   VAL 8   231 231 VAL VAL B . n 
C 1 9   LEU 9   232 232 LEU LEU B . n 
C 1 10  THR 10  233 233 THR THR B . n 
C 1 11  VAL 11  234 234 VAL VAL B . n 
C 1 12  GLU 12  235 235 GLU GLU B . n 
C 1 13  GLU 13  236 236 GLU GLU B . n 
C 1 14  MET 14  237 237 MET MET B . n 
C 1 15  THR 15  238 238 THR THR B . n 
C 1 16  ASN 16  239 239 ASN ASN B . n 
C 1 17  SER 17  240 240 SER SER B . n 
C 1 18  ARG 18  241 241 ARG ARG B . n 
C 1 19  PHE 19  242 242 PHE PHE B . n 
C 1 20  PRO 20  243 243 PRO PRO B . n 
C 1 21  ILE 21  244 244 ILE ILE B . n 
C 1 22  PRO 22  245 245 PRO PRO B . n 
C 1 23  LEU 23  246 246 LEU LEU B . n 
C 1 24  GLU 24  247 247 GLU GLU B . n 
C 1 25  LYS 25  248 248 LYS LYS B . n 
C 1 26  LEU 26  249 249 LEU LEU B . n 
C 1 27  PHE 27  250 250 PHE PHE B . n 
C 1 28  THR 28  251 251 THR THR B . n 
C 1 29  GLY 29  252 252 GLY GLY B . n 
C 1 30  PRO 30  253 253 PRO PRO B . n 
C 1 31  SER 31  254 254 SER SER B . n 
C 1 32  SER 32  255 255 SER SER B . n 
C 1 33  ALA 33  256 256 ALA ALA B . n 
C 1 34  PHE 34  257 257 PHE PHE B . n 
C 1 35  VAL 35  258 258 VAL VAL B . n 
C 1 36  VAL 36  259 259 VAL VAL B . n 
C 1 37  GLN 37  260 260 GLN GLN B . n 
C 1 38  PRO 38  261 261 PRO PRO B . n 
C 1 39  GLN 39  262 262 GLN GLN B . n 
C 1 40  ASN 40  263 263 ASN ASN B . n 
C 1 41  GLY 41  264 264 GLY GLY B . n 
C 1 42  ARG 42  265 265 ARG ARG B . n 
C 1 43  CYS 43  266 266 CYS CYS B . n 
C 1 44  THR 44  267 267 THR THR B . n 
C 1 45  THR 45  268 268 THR THR B . n 
C 1 46  ASP 46  269 269 ASP ASP B . n 
C 1 47  GLY 47  270 270 GLY GLY B . n 
C 1 48  VAL 48  271 271 VAL VAL B . n 
C 1 49  LEU 49  272 272 LEU LEU B . n 
C 1 50  LEU 50  273 273 LEU LEU B . n 
C 1 51  GLY 51  274 274 GLY GLY B . n 
C 1 52  THR 52  275 275 THR THR B . n 
C 1 53  THR 53  276 276 THR THR B . n 
C 1 54  GLN 54  277 277 GLN GLN B . n 
C 1 55  LEU 55  278 278 LEU LEU B . n 
C 1 56  SER 56  279 279 SER SER B . n 
C 1 57  PRO 57  280 280 PRO PRO B . n 
C 1 58  VAL 58  281 281 VAL VAL B . n 
C 1 59  ASN 59  282 282 ASN ASN B . n 
C 1 60  ILE 60  283 283 ILE ILE B . n 
C 1 61  CYS 61  284 284 CYS CYS B . n 
C 1 62  THR 62  285 285 THR THR B . n 
C 1 63  PHE 63  286 286 PHE PHE B . n 
C 1 64  ARG 64  287 287 ARG ARG B . n 
C 1 65  GLY 65  288 288 GLY GLY B . n 
C 1 66  ASP 66  289 289 ASP ASP B . n 
C 1 67  VAL 67  290 290 VAL VAL B . n 
C 1 68  THR 68  291 291 THR THR B . n 
C 1 69  HIS 69  292 292 HIS HIS B . n 
C 1 70  ILE 70  293 293 ILE ILE B . n 
C 1 71  THR 71  294 294 THR THR B . n 
C 1 72  GLY 72  295 295 GLY GLY B . n 
C 1 73  SER 73  296 296 SER SER B . n 
C 1 74  ARG 74  297 297 ARG ARG B . n 
C 1 75  ASN 75  298 298 ASN ASN B . n 
C 1 76  TYR 76  299 299 TYR TYR B . n 
C 1 77  THR 77  300 300 THR THR B . n 
C 1 78  MET 78  301 301 MET MET B . n 
C 1 79  ASN 79  302 302 ASN ASN B . n 
C 1 80  LEU 80  303 303 LEU LEU B . n 
C 1 81  ALA 81  304 304 ALA ALA B . n 
C 1 82  SER 82  305 305 SER SER B . n 
C 1 83  GLN 83  306 306 GLN GLN B . n 
C 1 84  ASN 84  307 307 ASN ASN B . n 
C 1 85  TRP 85  308 308 TRP TRP B . n 
C 1 86  ASN 86  309 309 ASN ASN B . n 
C 1 87  ASP 87  310 310 ASP ASP B . n 
C 1 88  TYR 88  311 311 TYR TYR B . n 
C 1 89  ASP 89  312 312 ASP ASP B . n 
C 1 90  PRO 90  313 313 PRO PRO B . n 
C 1 91  THR 91  314 314 THR THR B . n 
C 1 92  GLU 92  315 315 GLU GLU B . n 
C 1 93  GLU 93  316 316 GLU GLU B . n 
C 1 94  ILE 94  317 317 ILE ILE B . n 
C 1 95  PRO 95  318 318 PRO PRO B . n 
C 1 96  ALA 96  319 319 ALA ALA B . n 
C 1 97  PRO 97  320 320 PRO PRO B . n 
C 1 98  LEU 98  321 321 LEU LEU B . n 
C 1 99  GLY 99  322 322 GLY GLY B . n 
C 1 100 THR 100 323 323 THR THR B . n 
C 1 101 PRO 101 324 324 PRO PRO B . n 
C 1 102 ASP 102 325 325 ASP ASP B . n 
C 1 103 PHE 103 326 326 PHE PHE B . n 
C 1 104 VAL 104 327 327 VAL VAL B . n 
C 1 105 GLY 105 328 328 GLY GLY B . n 
C 1 106 LYS 106 329 329 LYS LYS B . n 
C 1 107 ILE 107 330 330 ILE ILE B . n 
C 1 108 GLN 108 331 331 GLN GLN B . n 
C 1 109 GLY 109 332 332 GLY GLY B . n 
C 1 110 VAL 110 333 333 VAL VAL B . n 
C 1 111 LEU 111 334 334 LEU LEU B . n 
C 1 112 THR 112 335 335 THR THR B . n 
C 1 113 GLN 113 336 336 GLN GLN B . n 
C 1 114 THR 114 337 337 THR THR B . n 
C 1 115 THR 115 338 338 THR THR B . n 
C 1 116 ARG 116 339 339 ARG ARG B . n 
C 1 117 THR 117 340 340 THR THR B . n 
C 1 118 ASP 118 341 341 ASP ASP B . n 
C 1 119 GLY 119 342 342 GLY GLY B . n 
C 1 120 SER 120 343 343 SER SER B . n 
C 1 121 THR 121 344 344 THR THR B . n 
C 1 122 ARG 122 345 345 ARG ARG B . n 
C 1 123 GLY 123 346 346 GLY GLY B . n 
C 1 124 HIS 124 347 347 HIS HIS B . n 
C 1 125 LYS 125 348 348 LYS LYS B . n 
C 1 126 ALA 126 349 349 ALA ALA B . n 
C 1 127 THR 127 350 350 THR THR B . n 
C 1 128 VAL 128 351 351 VAL VAL B . n 
C 1 129 TYR 129 352 352 TYR TYR B . n 
C 1 130 THR 130 353 353 THR THR B . n 
C 1 131 GLY 131 354 354 GLY GLY B . n 
C 1 132 SER 132 355 355 SER SER B . n 
C 1 133 ALA 133 356 356 ALA ALA B . n 
C 1 134 ASP 134 357 357 ASP ASP B . n 
C 1 135 PHE 135 358 358 PHE PHE B . n 
C 1 136 ALA 136 359 359 ALA ALA B . n 
C 1 137 PRO 137 360 360 PRO PRO B . n 
C 1 138 LYS 138 361 361 LYS LYS B . n 
C 1 139 LEU 139 362 362 LEU LEU B . n 
C 1 140 GLY 140 363 363 GLY GLY B . n 
C 1 141 ARG 141 364 364 ARG ARG B . n 
C 1 142 VAL 142 365 365 VAL VAL B . n 
C 1 143 GLN 143 366 366 GLN GLN B . n 
C 1 144 PHE 144 367 367 PHE PHE B . n 
C 1 145 GLU 145 368 368 GLU GLU B . n 
C 1 146 THR 146 369 369 THR THR B . n 
C 1 147 ASP 147 370 370 ASP ASP B . n 
C 1 148 THR 148 371 371 THR THR B . n 
C 1 149 ASP 149 372 372 ASP ASP B . n 
C 1 150 ARG 150 373 373 ARG ARG B . n 
C 1 151 ASP 151 374 374 ASP ASP B . n 
C 1 152 PHE 152 375 375 PHE PHE B . n 
C 1 153 GLU 153 376 376 GLU GLU B . n 
C 1 154 ALA 154 377 377 ALA ALA B . n 
C 1 155 ASN 155 378 378 ASN ASN B . n 
C 1 156 GLN 156 379 379 GLN GLN B . n 
C 1 157 ASN 157 380 380 ASN ASN B . n 
C 1 158 THR 158 381 381 THR THR B . n 
C 1 159 LYS 159 382 382 LYS LYS B . n 
C 1 160 PHE 160 383 383 PHE PHE B . n 
C 1 161 THR 161 384 384 THR THR B . n 
C 1 162 PRO 162 385 385 PRO PRO B . n 
C 1 163 VAL 163 386 386 VAL VAL B . n 
C 1 164 GLY 164 387 387 GLY GLY B . n 
C 1 165 VAL 165 388 388 VAL VAL B . n 
C 1 166 ILE 166 389 389 ILE ILE B . n 
C 1 167 GLN 167 390 390 GLN GLN B . n 
C 1 168 ASP 168 391 391 ASP ASP B . n 
C 1 169 GLY 169 392 392 GLY GLY B . n 
C 1 170 GLY 170 393 393 GLY GLY B . n 
C 1 171 THR 171 394 394 THR THR B . n 
C 1 172 THR 172 395 395 THR THR B . n 
C 1 173 HIS 173 396 396 HIS HIS B . n 
C 1 174 ARG 174 397 397 ARG ARG B . n 
C 1 175 ASN 175 398 398 ASN ASN B . n 
C 1 176 GLU 176 399 399 GLU GLU B . n 
C 1 177 PRO 177 400 400 PRO PRO B . n 
C 1 178 GLN 178 401 401 GLN GLN B . n 
C 1 179 GLN 179 402 402 GLN GLN B . n 
C 1 180 TRP 180 403 403 TRP TRP B . n 
C 1 181 VAL 181 404 404 VAL VAL B . n 
C 1 182 LEU 182 405 405 LEU LEU B . n 
C 1 183 PRO 183 406 406 PRO PRO B . n 
C 1 184 SER 184 407 407 SER SER B . n 
C 1 185 TYR 185 408 408 TYR TYR B . n 
C 1 186 SER 186 409 409 SER SER B . n 
C 1 187 GLY 187 410 410 GLY GLY B . n 
C 1 188 ARG 188 411 411 ARG ARG B . n 
C 1 189 ASN 189 412 412 ASN ASN B . n 
C 1 190 THR 190 413 413 THR THR B . n 
C 1 191 HIS 191 414 414 HIS HIS B . n 
C 1 192 ASN 192 415 415 ASN ASN B . n 
C 1 193 VAL 193 416 416 VAL VAL B . n 
C 1 194 HIS 194 417 417 HIS HIS B . n 
C 1 195 LEU 195 418 418 LEU LEU B . n 
C 1 196 ALA 196 419 419 ALA ALA B . n 
C 1 197 PRO 197 420 420 PRO PRO B . n 
C 1 198 ALA 198 421 421 ALA ALA B . n 
C 1 199 VAL 199 422 422 VAL VAL B . n 
C 1 200 ALA 200 423 423 ALA ALA B . n 
C 1 201 PRO 201 424 424 PRO PRO B . n 
C 1 202 THR 202 425 425 THR THR B . n 
C 1 203 PHE 203 426 426 PHE PHE B . n 
C 1 204 PRO 204 427 427 PRO PRO B . n 
C 1 205 GLY 205 428 428 GLY GLY B . n 
C 1 206 GLU 206 429 429 GLU GLU B . n 
C 1 207 GLN 207 430 430 GLN GLN B . n 
C 1 208 LEU 208 431 431 LEU LEU B . n 
C 1 209 LEU 209 432 432 LEU LEU B . n 
C 1 210 PHE 210 433 433 PHE PHE B . n 
C 1 211 PHE 211 434 434 PHE PHE B . n 
C 1 212 ARG 212 435 435 ARG ARG B . n 
C 1 213 SER 213 436 436 SER SER B . n 
C 1 214 THR 214 437 437 THR THR B . n 
C 1 215 MET 215 438 438 MET MET B . n 
C 1 216 PRO 216 439 439 PRO PRO B . n 
C 1 217 GLY 217 440 440 GLY GLY B . n 
C 1 218 CYS 218 441 441 CYS CYS B . n 
C 1 219 SER 219 442 442 SER SER B . n 
C 1 220 GLY 220 443 443 GLY GLY B . n 
C 1 221 TYR 221 444 444 TYR TYR B . n 
C 1 222 PRO 222 445 445 PRO PRO B . n 
C 1 223 ASN 223 446 446 ASN ASN B . n 
C 1 224 MET 224 447 447 MET MET B . n 
C 1 225 ASP 225 448 448 ASP ASP B . n 
C 1 226 LEU 226 449 449 LEU LEU B . n 
C 1 227 ASP 227 450 450 ASP ASP B . n 
C 1 228 CYS 228 451 451 CYS CYS B . n 
C 1 229 LEU 229 452 452 LEU LEU B . n 
C 1 230 LEU 230 453 453 LEU LEU B . n 
C 1 231 PRO 231 454 454 PRO PRO B . n 
C 1 232 GLN 232 455 455 GLN GLN B . n 
C 1 233 GLU 233 456 456 GLU GLU B . n 
C 1 234 TRP 234 457 457 TRP TRP B . n 
C 1 235 VAL 235 458 458 VAL VAL B . n 
C 1 236 GLN 236 459 459 GLN GLN B . n 
C 1 237 TYR 237 460 460 TYR TYR B . n 
C 1 238 PHE 238 461 461 PHE PHE B . n 
C 1 239 TYR 239 462 462 TYR TYR B . n 
C 1 240 GLN 240 463 463 GLN GLN B . n 
C 1 241 GLU 241 464 464 GLU GLU B . n 
C 1 242 ALA 242 465 465 ALA ALA B . n 
C 1 243 ALA 243 466 466 ALA ALA B . n 
C 1 244 PRO 244 467 467 PRO PRO B . n 
C 1 245 ALA 245 468 468 ALA ALA B . n 
C 1 246 GLN 246 469 469 GLN GLN B . n 
C 1 247 SER 247 470 470 SER SER B . n 
C 1 248 ASP 248 471 471 ASP ASP B . n 
C 1 249 VAL 249 472 472 VAL VAL B . n 
C 1 250 ALA 250 473 473 ALA ALA B . n 
C 1 251 LEU 251 474 474 LEU LEU B . n 
C 1 252 LEU 252 475 475 LEU LEU B . n 
C 1 253 ARG 253 476 476 ARG ARG B . n 
C 1 254 PHE 254 477 477 PHE PHE B . n 
C 1 255 VAL 255 478 478 VAL VAL B . n 
C 1 256 ASN 256 479 479 ASN ASN B . n 
C 1 257 PRO 257 480 480 PRO PRO B . n 
C 1 258 ASP 258 481 481 ASP ASP B . n 
C 1 259 THR 259 482 482 THR THR B . n 
C 1 260 GLY 260 483 483 GLY GLY B . n 
C 1 261 ARG 261 484 484 ARG ARG B . n 
C 1 262 VAL 262 485 485 VAL VAL B . n 
C 1 263 LEU 263 486 486 LEU LEU B . n 
C 1 264 PHE 264 487 487 PHE PHE B . n 
C 1 265 GLU 265 488 488 GLU GLU B . n 
C 1 266 CYS 266 489 489 CYS CYS B . n 
C 1 267 LYS 267 490 490 LYS LYS B . n 
C 1 268 LEU 268 491 491 LEU LEU B . n 
C 1 269 HIS 269 492 492 HIS HIS B . n 
C 1 270 LYS 270 493 493 LYS LYS B . n 
C 1 271 SER 271 494 494 SER SER B . n 
C 1 272 GLY 272 495 495 GLY GLY B . n 
C 1 273 TYR 273 496 496 TYR TYR B . n 
C 1 274 VAL 274 497 497 VAL VAL B . n 
C 1 275 THR 275 498 498 THR THR B . n 
C 1 276 VAL 276 499 499 VAL VAL B . n 
C 1 277 ALA 277 500 500 ALA ALA B . n 
C 1 278 HIS 278 501 501 HIS HIS B . n 
C 1 279 THR 279 502 502 THR THR B . n 
C 1 280 GLY 280 503 503 GLY GLY B . n 
C 1 281 GLN 281 504 504 GLN GLN B . n 
C 1 282 HIS 282 505 505 HIS HIS B . n 
C 1 283 ASP 283 506 506 ASP ASP B . n 
C 1 284 LEU 284 507 507 LEU LEU B . n 
C 1 285 VAL 285 508 508 VAL VAL B . n 
C 1 286 ILE 286 509 509 ILE ILE B . n 
C 1 287 PRO 287 510 510 PRO PRO B . n 
C 1 288 PRO 288 511 511 PRO PRO B . n 
C 1 289 ASN 289 512 512 ASN ASN B . n 
C 1 290 GLY 290 513 513 GLY GLY B . n 
C 1 291 TYR 291 514 514 TYR TYR B . n 
C 1 292 PHE 292 515 515 PHE PHE B . n 
C 1 293 ARG 293 516 516 ARG ARG B . n 
C 1 294 PHE 294 517 517 PHE PHE B . n 
C 1 295 ASP 295 518 518 ASP ASP B . n 
C 1 296 SER 296 519 519 SER SER B . n 
C 1 297 TRP 297 520 520 TRP TRP B . n 
C 1 298 VAL 298 521 521 VAL VAL B . n 
C 1 299 ASN 299 522 522 ASN ASN B . n 
C 1 300 GLN 300 523 523 GLN GLN B . n 
C 1 301 PHE 301 524 524 PHE PHE B . n 
C 1 302 TYR 302 525 525 TYR TYR B . n 
C 1 303 THR 303 526 526 THR THR B . n 
C 1 304 LEU 304 527 527 LEU LEU B . n 
C 1 305 ALA 305 528 528 ALA ALA B . n 
C 1 306 PRO 306 529 529 PRO PRO B . n 
C 1 307 MET 307 530 530 MET MET B . n 
D 2 1   GLN 1   1   1   GLN GLN D . n 
D 2 2   VAL 2   2   2   VAL VAL D . n 
D 2 3   GLN 3   3   3   GLN GLN D . n 
D 2 4   LEU 4   4   4   LEU LEU D . n 
D 2 5   GLN 5   5   5   GLN GLN D . n 
D 2 6   GLU 6   6   6   GLU GLU D . n 
D 2 7   SER 7   7   7   SER SER D . n 
D 2 8   GLY 8   8   8   GLY GLY D . n 
D 2 9   GLY 9   9   9   GLY GLY D . n 
D 2 10  GLY 10  10  10  GLY GLY D . n 
D 2 11  LEU 11  11  11  LEU LEU D . n 
D 2 12  VAL 12  12  12  VAL VAL D . n 
D 2 13  GLN 13  13  13  GLN GLN D . n 
D 2 14  ALA 14  14  14  ALA ALA D . n 
D 2 15  GLY 15  15  15  GLY GLY D . n 
D 2 16  GLY 16  16  16  GLY GLY D . n 
D 2 17  SER 17  17  17  SER SER D . n 
D 2 18  LEU 18  18  18  LEU LEU D . n 
D 2 19  ARG 19  19  19  ARG ARG D . n 
D 2 20  LEU 20  20  20  LEU LEU D . n 
D 2 21  SER 21  21  21  SER SER D . n 
D 2 22  CYS 22  22  22  CYS CYS D . n 
D 2 23  ALA 23  23  23  ALA ALA D . n 
D 2 24  ALA 24  24  24  ALA ALA D . n 
D 2 25  SER 25  25  25  SER SER D . n 
D 2 26  GLY 26  26  26  GLY GLY D . n 
D 2 27  THR 27  27  27  THR THR D . n 
D 2 28  ILE 28  28  28  ILE ILE D . n 
D 2 29  PHE 29  29  29  PHE PHE D . n 
D 2 30  SER 30  30  30  SER SER D . n 
D 2 31  ILE 31  31  31  ILE ILE D . n 
D 2 32  ASP 32  32  32  ASP ASP D . n 
D 2 33  ALA 33  33  33  ALA ALA D . n 
D 2 34  PHE 34  34  34  PHE PHE D . n 
D 2 35  GLY 35  35  35  GLY GLY D . n 
D 2 36  TRP 36  36  36  TRP TRP D . n 
D 2 37  TYR 37  37  37  TYR TYR D . n 
D 2 38  ARG 38  38  38  ARG ARG D . n 
D 2 39  GLN 39  39  39  GLN GLN D . n 
D 2 40  ALA 40  40  40  ALA ALA D . n 
D 2 41  PRO 41  41  41  PRO PRO D . n 
D 2 42  GLY 42  42  42  GLY GLY D . n 
D 2 43  LYS 43  43  43  LYS LYS D . n 
D 2 44  GLN 44  44  44  GLN GLN D . n 
D 2 45  ARG 45  45  45  ARG ARG D . n 
D 2 46  GLU 46  46  46  GLU GLU D . n 
D 2 47  TRP 47  47  47  TRP TRP D . n 
D 2 48  VAL 48  48  48  VAL VAL D . n 
D 2 49  ALA 49  49  49  ALA ALA D . n 
D 2 50  GLY 50  50  50  GLY GLY D . n 
D 2 51  ILE 51  51  51  ILE ILE D . n 
D 2 52  THR 52  52  52  THR THR D . n 
D 2 53  SER 53  53  53  SER SER D . n 
D 2 54  GLY 54  54  54  GLY GLY D . n 
D 2 55  SER 55  55  55  SER SER D . n 
D 2 56  SER 56  56  56  SER SER D . n 
D 2 57  THR 57  57  57  THR THR D . n 
D 2 58  ILE 58  58  58  ILE ILE D . n 
D 2 59  TYR 59  59  59  TYR TYR D . n 
D 2 60  ALA 60  60  60  ALA ALA D . n 
D 2 61  ASP 61  61  61  ASP ASP D . n 
D 2 62  PHE 62  62  62  PHE PHE D . n 
D 2 63  VAL 63  63  63  VAL VAL D . n 
D 2 64  LYS 64  64  64  LYS LYS D . n 
D 2 65  GLY 65  65  65  GLY GLY D . n 
D 2 66  ARG 66  66  66  ARG ARG D . n 
D 2 67  PHE 67  67  67  PHE PHE D . n 
D 2 68  THR 68  68  68  THR THR D . n 
D 2 69  ILE 69  69  69  ILE ILE D . n 
D 2 70  SER 70  70  70  SER SER D . n 
D 2 71  ARG 71  71  71  ARG ARG D . n 
D 2 72  ASP 72  72  72  ASP ASP D . n 
D 2 73  ASN 73  73  73  ASN ASN D . n 
D 2 74  ALA 74  74  74  ALA ALA D . n 
D 2 75  LYS 75  75  75  LYS LYS D . n 
D 2 76  ASN 76  76  76  ASN ASN D . n 
D 2 77  THR 77  77  77  THR THR D . n 
D 2 78  VAL 78  78  78  VAL VAL D . n 
D 2 79  PHE 79  79  79  PHE PHE D . n 
D 2 80  LEU 80  80  80  LEU LEU D . n 
D 2 81  GLN 81  81  81  GLN GLN D . n 
D 2 82  MET 82  82  82  MET MET D . n 
D 2 83  ASN 83  83  83  ASN ASN D . n 
D 2 84  SER 84  84  84  SER SER D . n 
D 2 85  LEU 85  85  85  LEU LEU D . n 
D 2 86  LYS 86  86  86  LYS LYS D . n 
D 2 87  PRO 87  87  87  PRO PRO D . n 
D 2 88  GLU 88  88  88  GLU GLU D . n 
D 2 89  ASP 89  89  89  ASP ASP D . n 
D 2 90  THR 90  90  90  THR THR D . n 
D 2 91  ALA 91  91  91  ALA ALA D . n 
D 2 92  VAL 92  92  92  VAL VAL D . n 
D 2 93  TYR 93  93  93  TYR TYR D . n 
D 2 94  TYR 94  94  94  TYR TYR D . n 
D 2 95  CYS 95  95  95  CYS CYS D . n 
D 2 96  ASN 96  96  96  ASN ASN D . n 
D 2 97  ARG 97  97  97  ARG ARG D . n 
D 2 98  ALA 98  98  98  ALA ALA D . n 
D 2 99  LYS 99  99  99  LYS LYS D . n 
D 2 100 PRO 100 100 100 PRO PRO D . n 
D 2 101 PRO 101 101 101 PRO PRO D . n 
D 2 102 THR 102 102 102 THR THR D . n 
D 2 103 TYR 103 103 103 TYR TYR D . n 
D 2 104 TYR 104 104 104 TYR TYR D . n 
D 2 105 SER 105 105 105 SER SER D . n 
D 2 106 LEU 106 106 106 LEU LEU D . n 
D 2 107 GLU 107 107 107 GLU GLU D . n 
D 2 108 PRO 108 108 108 PRO PRO D . n 
D 2 109 TRP 109 109 109 TRP TRP D . n 
D 2 110 GLY 110 110 110 GLY GLY D . n 
D 2 111 LYS 111 111 111 LYS LYS D . n 
D 2 112 GLY 112 112 112 GLY GLY D . n 
D 2 113 THR 113 113 113 THR THR D . n 
D 2 114 GLN 114 114 114 GLN GLN D . n 
D 2 115 VAL 115 115 115 VAL VAL D . n 
D 2 116 THR 116 116 116 THR THR D . n 
D 2 117 VAL 117 117 117 VAL VAL D . n 
D 2 118 SER 118 118 118 SER SER D . n 
D 2 119 SER 119 119 119 SER SER D . n 
D 2 120 HIS 120 120 120 HIS HIS D . n 
D 2 121 HIS 121 121 ?   ?   ?   D . n 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              g.hansman@griffith.edu.au 
_pdbx_contact_author.name_first         Grant 
_pdbx_contact_author.name_last          Hansman 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-8735-4618 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 GOL 1   601  624 GOL GOL A . 
F 3 GOL 1   602  724 GOL GOL A . 
G 4 IPA 1   603  824 IPA IPA A . 
H 3 GOL 1   604  924 GOL GOL A . 
I 5 EDO 1   605  624 EDO EDO A . 
J 5 EDO 1   606  830 EDO EDO A . 
K 5 EDO 1   607  831 EDO EDO A . 
L 3 GOL 1   601  724 GOL GOL B . 
M 5 EDO 1   602  824 EDO EDO B . 
N 6 DMS 1   603  826 DMS DMS B . 
O 5 EDO 1   604  828 EDO EDO B . 
P 5 EDO 1   605  829 EDO EDO B . 
Q 5 EDO 1   201  201 EDO EDO D . 
R 3 GOL 1   202  301 GOL GOL D . 
S 4 IPA 1   203  401 IPA IPA D . 
T 7 HOH 1   701  696 HOH HOH A . 
T 7 HOH 2   702  423 HOH HOH A . 
T 7 HOH 3   703  629 HOH HOH A . 
T 7 HOH 4   704  644 HOH HOH A . 
T 7 HOH 5   705  375 HOH HOH A . 
T 7 HOH 6   706  442 HOH HOH A . 
T 7 HOH 7   707  795 HOH HOH A . 
T 7 HOH 8   708  662 HOH HOH A . 
T 7 HOH 9   709  432 HOH HOH A . 
T 7 HOH 10  710  735 HOH HOH A . 
T 7 HOH 11  711  359 HOH HOH A . 
T 7 HOH 12  712  669 HOH HOH A . 
T 7 HOH 13  713  673 HOH HOH A . 
T 7 HOH 14  714  864 HOH HOH A . 
T 7 HOH 15  715  567 HOH HOH A . 
T 7 HOH 16  716  247 HOH HOH A . 
T 7 HOH 17  717  632 HOH HOH A . 
T 7 HOH 18  718  191 HOH HOH A . 
T 7 HOH 19  719  620 HOH HOH A . 
T 7 HOH 20  720  408 HOH HOH A . 
T 7 HOH 21  721  134 HOH HOH A . 
T 7 HOH 22  722  781 HOH HOH A . 
T 7 HOH 23  723  185 HOH HOH A . 
T 7 HOH 24  724  861 HOH HOH A . 
T 7 HOH 25  725  81  HOH HOH A . 
T 7 HOH 26  726  48  HOH HOH A . 
T 7 HOH 27  727  840 HOH HOH A . 
T 7 HOH 28  728  401 HOH HOH A . 
T 7 HOH 29  729  343 HOH HOH A . 
T 7 HOH 30  730  450 HOH HOH A . 
T 7 HOH 31  731  580 HOH HOH A . 
T 7 HOH 32  732  21  HOH HOH A . 
T 7 HOH 33  733  590 HOH HOH A . 
T 7 HOH 34  734  535 HOH HOH A . 
T 7 HOH 35  735  293 HOH HOH A . 
T 7 HOH 36  736  43  HOH HOH A . 
T 7 HOH 37  737  485 HOH HOH A . 
T 7 HOH 38  738  88  HOH HOH A . 
T 7 HOH 39  739  519 HOH HOH A . 
T 7 HOH 40  740  595 HOH HOH A . 
T 7 HOH 41  741  421 HOH HOH A . 
T 7 HOH 42  742  141 HOH HOH A . 
T 7 HOH 43  743  518 HOH HOH A . 
T 7 HOH 44  744  193 HOH HOH A . 
T 7 HOH 45  745  584 HOH HOH A . 
T 7 HOH 46  746  230 HOH HOH A . 
T 7 HOH 47  747  276 HOH HOH A . 
T 7 HOH 48  748  437 HOH HOH A . 
T 7 HOH 49  749  768 HOH HOH A . 
T 7 HOH 50  750  195 HOH HOH A . 
T 7 HOH 51  751  710 HOH HOH A . 
T 7 HOH 52  752  416 HOH HOH A . 
T 7 HOH 53  753  487 HOH HOH A . 
T 7 HOH 54  754  116 HOH HOH A . 
T 7 HOH 55  755  106 HOH HOH A . 
T 7 HOH 56  756  203 HOH HOH A . 
T 7 HOH 57  757  94  HOH HOH A . 
T 7 HOH 58  758  100 HOH HOH A . 
T 7 HOH 59  759  348 HOH HOH A . 
T 7 HOH 60  760  52  HOH HOH A . 
T 7 HOH 61  761  559 HOH HOH A . 
T 7 HOH 62  762  493 HOH HOH A . 
T 7 HOH 63  763  61  HOH HOH A . 
T 7 HOH 64  764  182 HOH HOH A . 
T 7 HOH 65  765  515 HOH HOH A . 
T 7 HOH 66  766  427 HOH HOH A . 
T 7 HOH 67  767  638 HOH HOH A . 
T 7 HOH 68  768  103 HOH HOH A . 
T 7 HOH 69  769  657 HOH HOH A . 
T 7 HOH 70  770  565 HOH HOH A . 
T 7 HOH 71  771  350 HOH HOH A . 
T 7 HOH 72  772  128 HOH HOH A . 
T 7 HOH 73  773  241 HOH HOH A . 
T 7 HOH 74  774  18  HOH HOH A . 
T 7 HOH 75  775  678 HOH HOH A . 
T 7 HOH 76  776  441 HOH HOH A . 
T 7 HOH 77  777  44  HOH HOH A . 
T 7 HOH 78  778  489 HOH HOH A . 
T 7 HOH 79  779  139 HOH HOH A . 
T 7 HOH 80  780  737 HOH HOH A . 
T 7 HOH 81  781  805 HOH HOH A . 
T 7 HOH 82  782  234 HOH HOH A . 
T 7 HOH 83  783  814 HOH HOH A . 
T 7 HOH 84  784  160 HOH HOH A . 
T 7 HOH 85  785  232 HOH HOH A . 
T 7 HOH 86  786  469 HOH HOH A . 
T 7 HOH 87  787  26  HOH HOH A . 
T 7 HOH 88  788  719 HOH HOH A . 
T 7 HOH 89  789  395 HOH HOH A . 
T 7 HOH 90  790  226 HOH HOH A . 
T 7 HOH 91  791  32  HOH HOH A . 
T 7 HOH 92  792  498 HOH HOH A . 
T 7 HOH 93  793  409 HOH HOH A . 
T 7 HOH 94  794  270 HOH HOH A . 
T 7 HOH 95  795  433 HOH HOH A . 
T 7 HOH 96  796  681 HOH HOH A . 
T 7 HOH 97  797  168 HOH HOH A . 
T 7 HOH 98  798  454 HOH HOH A . 
T 7 HOH 99  799  419 HOH HOH A . 
T 7 HOH 100 800  335 HOH HOH A . 
T 7 HOH 101 801  327 HOH HOH A . 
T 7 HOH 102 802  245 HOH HOH A . 
T 7 HOH 103 803  312 HOH HOH A . 
T 7 HOH 104 804  242 HOH HOH A . 
T 7 HOH 105 805  846 HOH HOH A . 
T 7 HOH 106 806  17  HOH HOH A . 
T 7 HOH 107 807  542 HOH HOH A . 
T 7 HOH 108 808  467 HOH HOH A . 
T 7 HOH 109 809  142 HOH HOH A . 
T 7 HOH 110 810  509 HOH HOH A . 
T 7 HOH 111 811  8   HOH HOH A . 
T 7 HOH 112 812  55  HOH HOH A . 
T 7 HOH 113 813  125 HOH HOH A . 
T 7 HOH 114 814  283 HOH HOH A . 
T 7 HOH 115 815  87  HOH HOH A . 
T 7 HOH 116 816  28  HOH HOH A . 
T 7 HOH 117 817  221 HOH HOH A . 
T 7 HOH 118 818  123 HOH HOH A . 
T 7 HOH 119 819  391 HOH HOH A . 
T 7 HOH 120 820  159 HOH HOH A . 
T 7 HOH 121 821  119 HOH HOH A . 
T 7 HOH 122 822  389 HOH HOH A . 
T 7 HOH 123 823  99  HOH HOH A . 
T 7 HOH 124 824  102 HOH HOH A . 
T 7 HOH 125 825  592 HOH HOH A . 
T 7 HOH 126 826  446 HOH HOH A . 
T 7 HOH 127 827  178 HOH HOH A . 
T 7 HOH 128 828  137 HOH HOH A . 
T 7 HOH 129 829  105 HOH HOH A . 
T 7 HOH 130 830  11  HOH HOH A . 
T 7 HOH 131 831  555 HOH HOH A . 
T 7 HOH 132 832  793 HOH HOH A . 
T 7 HOH 133 833  108 HOH HOH A . 
T 7 HOH 134 834  304 HOH HOH A . 
T 7 HOH 135 835  664 HOH HOH A . 
T 7 HOH 136 836  115 HOH HOH A . 
T 7 HOH 137 837  184 HOH HOH A . 
T 7 HOH 138 838  95  HOH HOH A . 
T 7 HOH 139 839  7   HOH HOH A . 
T 7 HOH 140 840  616 HOH HOH A . 
T 7 HOH 141 841  224 HOH HOH A . 
T 7 HOH 142 842  855 HOH HOH A . 
T 7 HOH 143 843  633 HOH HOH A . 
T 7 HOH 144 844  121 HOH HOH A . 
T 7 HOH 145 845  151 HOH HOH A . 
T 7 HOH 146 846  294 HOH HOH A . 
T 7 HOH 147 847  362 HOH HOH A . 
T 7 HOH 148 848  215 HOH HOH A . 
T 7 HOH 149 849  238 HOH HOH A . 
T 7 HOH 150 850  140 HOH HOH A . 
T 7 HOH 151 851  449 HOH HOH A . 
T 7 HOH 152 852  724 HOH HOH A . 
T 7 HOH 153 853  268 HOH HOH A . 
T 7 HOH 154 854  228 HOH HOH A . 
T 7 HOH 155 855  156 HOH HOH A . 
T 7 HOH 156 856  477 HOH HOH A . 
T 7 HOH 157 857  84  HOH HOH A . 
T 7 HOH 158 858  319 HOH HOH A . 
T 7 HOH 159 859  263 HOH HOH A . 
T 7 HOH 160 860  411 HOH HOH A . 
T 7 HOH 161 861  550 HOH HOH A . 
T 7 HOH 162 862  835 HOH HOH A . 
T 7 HOH 163 863  138 HOH HOH A . 
T 7 HOH 164 864  40  HOH HOH A . 
T 7 HOH 165 865  82  HOH HOH A . 
T 7 HOH 166 866  27  HOH HOH A . 
T 7 HOH 167 867  165 HOH HOH A . 
T 7 HOH 168 868  110 HOH HOH A . 
T 7 HOH 169 869  436 HOH HOH A . 
T 7 HOH 170 870  679 HOH HOH A . 
T 7 HOH 171 871  334 HOH HOH A . 
T 7 HOH 172 872  101 HOH HOH A . 
T 7 HOH 173 873  167 HOH HOH A . 
T 7 HOH 174 874  150 HOH HOH A . 
T 7 HOH 175 875  798 HOH HOH A . 
T 7 HOH 176 876  785 HOH HOH A . 
T 7 HOH 177 877  692 HOH HOH A . 
T 7 HOH 178 878  2   HOH HOH A . 
T 7 HOH 179 879  836 HOH HOH A . 
T 7 HOH 180 880  670 HOH HOH A . 
T 7 HOH 181 881  714 HOH HOH A . 
T 7 HOH 182 882  206 HOH HOH A . 
T 7 HOH 183 883  209 HOH HOH A . 
T 7 HOH 184 884  243 HOH HOH A . 
T 7 HOH 185 885  111 HOH HOH A . 
T 7 HOH 186 886  273 HOH HOH A . 
T 7 HOH 187 887  810 HOH HOH A . 
T 7 HOH 188 888  472 HOH HOH A . 
T 7 HOH 189 889  269 HOH HOH A . 
T 7 HOH 190 890  144 HOH HOH A . 
T 7 HOH 191 891  782 HOH HOH A . 
T 7 HOH 192 892  474 HOH HOH A . 
T 7 HOH 193 893  503 HOH HOH A . 
T 7 HOH 194 894  75  HOH HOH A . 
T 7 HOH 195 895  397 HOH HOH A . 
T 7 HOH 196 896  78  HOH HOH A . 
T 7 HOH 197 897  132 HOH HOH A . 
T 7 HOH 198 898  566 HOH HOH A . 
T 7 HOH 199 899  622 HOH HOH A . 
T 7 HOH 200 900  179 HOH HOH A . 
T 7 HOH 201 901  186 HOH HOH A . 
T 7 HOH 202 902  507 HOH HOH A . 
T 7 HOH 203 903  686 HOH HOH A . 
T 7 HOH 204 904  299 HOH HOH A . 
T 7 HOH 205 905  510 HOH HOH A . 
T 7 HOH 206 906  290 HOH HOH A . 
T 7 HOH 207 907  214 HOH HOH A . 
T 7 HOH 208 908  280 HOH HOH A . 
T 7 HOH 209 909  393 HOH HOH A . 
T 7 HOH 210 910  313 HOH HOH A . 
T 7 HOH 211 911  56  HOH HOH A . 
T 7 HOH 212 912  405 HOH HOH A . 
T 7 HOH 213 913  183 HOH HOH A . 
T 7 HOH 214 914  468 HOH HOH A . 
T 7 HOH 215 915  815 HOH HOH A . 
T 7 HOH 216 916  284 HOH HOH A . 
T 7 HOH 217 917  255 HOH HOH A . 
T 7 HOH 218 918  367 HOH HOH A . 
T 7 HOH 219 919  558 HOH HOH A . 
T 7 HOH 220 920  727 HOH HOH A . 
T 7 HOH 221 921  345 HOH HOH A . 
T 7 HOH 222 922  122 HOH HOH A . 
T 7 HOH 223 923  59  HOH HOH A . 
T 7 HOH 224 924  219 HOH HOH A . 
T 7 HOH 225 925  337 HOH HOH A . 
T 7 HOH 226 926  649 HOH HOH A . 
T 7 HOH 227 927  292 HOH HOH A . 
T 7 HOH 228 928  451 HOH HOH A . 
T 7 HOH 229 929  363 HOH HOH A . 
T 7 HOH 230 930  296 HOH HOH A . 
T 7 HOH 231 931  342 HOH HOH A . 
T 7 HOH 232 932  707 HOH HOH A . 
T 7 HOH 233 933  20  HOH HOH A . 
T 7 HOH 234 934  4   HOH HOH A . 
T 7 HOH 235 935  833 HOH HOH A . 
T 7 HOH 236 936  145 HOH HOH A . 
T 7 HOH 237 937  786 HOH HOH A . 
T 7 HOH 238 938  753 HOH HOH A . 
T 7 HOH 239 939  166 HOH HOH A . 
T 7 HOH 240 940  520 HOH HOH A . 
T 7 HOH 241 941  809 HOH HOH A . 
T 7 HOH 242 942  837 HOH HOH A . 
T 7 HOH 243 943  556 HOH HOH A . 
T 7 HOH 244 944  732 HOH HOH A . 
T 7 HOH 245 945  608 HOH HOH A . 
T 7 HOH 246 946  740 HOH HOH A . 
T 7 HOH 247 947  398 HOH HOH A . 
T 7 HOH 248 948  390 HOH HOH A . 
T 7 HOH 249 949  404 HOH HOH A . 
T 7 HOH 250 950  687 HOH HOH A . 
T 7 HOH 251 951  553 HOH HOH A . 
T 7 HOH 252 952  525 HOH HOH A . 
T 7 HOH 253 953  322 HOH HOH A . 
T 7 HOH 254 954  170 HOH HOH A . 
T 7 HOH 255 955  818 HOH HOH A . 
T 7 HOH 256 956  748 HOH HOH A . 
T 7 HOH 257 957  799 HOH HOH A . 
T 7 HOH 258 958  443 HOH HOH A . 
T 7 HOH 259 959  196 HOH HOH A . 
T 7 HOH 260 960  789 HOH HOH A . 
T 7 HOH 261 961  607 HOH HOH A . 
T 7 HOH 262 962  755 HOH HOH A . 
T 7 HOH 263 963  722 HOH HOH A . 
T 7 HOH 264 964  333 HOH HOH A . 
T 7 HOH 265 965  720 HOH HOH A . 
T 7 HOH 266 966  811 HOH HOH A . 
T 7 HOH 267 967  597 HOH HOH A . 
T 7 HOH 268 968  752 HOH HOH A . 
T 7 HOH 269 969  651 HOH HOH A . 
T 7 HOH 270 970  746 HOH HOH A . 
T 7 HOH 271 971  526 HOH HOH A . 
T 7 HOH 272 972  577 HOH HOH A . 
T 7 HOH 273 973  287 HOH HOH A . 
T 7 HOH 274 974  340 HOH HOH A . 
T 7 HOH 275 975  366 HOH HOH A . 
T 7 HOH 276 976  796 HOH HOH A . 
T 7 HOH 277 977  824 HOH HOH A . 
T 7 HOH 278 978  715 HOH HOH A . 
T 7 HOH 279 979  434 HOH HOH A . 
T 7 HOH 280 980  339 HOH HOH A . 
T 7 HOH 281 981  251 HOH HOH A . 
T 7 HOH 282 982  850 HOH HOH A . 
T 7 HOH 283 983  759 HOH HOH A . 
T 7 HOH 284 984  775 HOH HOH A . 
T 7 HOH 285 985  396 HOH HOH A . 
T 7 HOH 286 986  827 HOH HOH A . 
T 7 HOH 287 987  825 HOH HOH A . 
T 7 HOH 288 988  751 HOH HOH A . 
T 7 HOH 289 989  494 HOH HOH A . 
T 7 HOH 290 990  501 HOH HOH A . 
T 7 HOH 291 991  521 HOH HOH A . 
T 7 HOH 292 992  728 HOH HOH A . 
T 7 HOH 293 993  709 HOH HOH A . 
T 7 HOH 294 994  536 HOH HOH A . 
T 7 HOH 295 995  750 HOH HOH A . 
T 7 HOH 296 996  278 HOH HOH A . 
T 7 HOH 297 997  470 HOH HOH A . 
T 7 HOH 298 998  514 HOH HOH A . 
T 7 HOH 299 999  859 HOH HOH A . 
T 7 HOH 300 1000 762 HOH HOH A . 
T 7 HOH 301 1001 829 HOH HOH A . 
T 7 HOH 302 1002 207 HOH HOH A . 
T 7 HOH 303 1003 422 HOH HOH A . 
T 7 HOH 304 1004 733 HOH HOH A . 
T 7 HOH 305 1005 826 HOH HOH A . 
T 7 HOH 306 1006 430 HOH HOH A . 
T 7 HOH 307 1007 734 HOH HOH A . 
T 7 HOH 308 1008 420 HOH HOH A . 
T 7 HOH 309 1009 656 HOH HOH A . 
T 7 HOH 310 1010 548 HOH HOH A . 
T 7 HOH 311 1011 739 HOH HOH A . 
T 7 HOH 312 1012 757 HOH HOH A . 
T 7 HOH 313 1013 289 HOH HOH A . 
T 7 HOH 314 1014 576 HOH HOH A . 
T 7 HOH 315 1015 573 HOH HOH A . 
T 7 HOH 316 1016 849 HOH HOH A . 
T 7 HOH 317 1017 459 HOH HOH A . 
T 7 HOH 318 1018 504 HOH HOH A . 
T 7 HOH 319 1019 852 HOH HOH A . 
T 7 HOH 320 1020 539 HOH HOH A . 
T 7 HOH 321 1021 508 HOH HOH A . 
T 7 HOH 322 1022 349 HOH HOH A . 
U 7 HOH 1   201  726 HOH HOH C . 
U 7 HOH 2   202  636 HOH HOH C . 
U 7 HOH 3   203  267 HOH HOH C . 
U 7 HOH 4   204  682 HOH HOH C . 
U 7 HOH 5   205  702 HOH HOH C . 
U 7 HOH 6   206  344 HOH HOH C . 
U 7 HOH 7   207  211 HOH HOH C . 
U 7 HOH 8   208  461 HOH HOH C . 
U 7 HOH 9   209  643 HOH HOH C . 
U 7 HOH 10  210  783 HOH HOH C . 
U 7 HOH 11  211  531 HOH HOH C . 
U 7 HOH 12  212  568 HOH HOH C . 
U 7 HOH 13  213  272 HOH HOH C . 
U 7 HOH 14  214  482 HOH HOH C . 
U 7 HOH 15  215  583 HOH HOH C . 
U 7 HOH 16  216  266 HOH HOH C . 
U 7 HOH 17  217  634 HOH HOH C . 
U 7 HOH 18  218  648 HOH HOH C . 
U 7 HOH 19  219  259 HOH HOH C . 
U 7 HOH 20  220  563 HOH HOH C . 
U 7 HOH 21  221  499 HOH HOH C . 
U 7 HOH 22  222  530 HOH HOH C . 
U 7 HOH 23  223  394 HOH HOH C . 
U 7 HOH 24  224  790 HOH HOH C . 
U 7 HOH 25  225  463 HOH HOH C . 
U 7 HOH 26  226  816 HOH HOH C . 
U 7 HOH 27  227  604 HOH HOH C . 
U 7 HOH 28  228  703 HOH HOH C . 
U 7 HOH 29  229  328 HOH HOH C . 
U 7 HOH 30  230  731 HOH HOH C . 
U 7 HOH 31  231  464 HOH HOH C . 
U 7 HOH 32  232  465 HOH HOH C . 
U 7 HOH 33  233  426 HOH HOH C . 
U 7 HOH 34  234  109 HOH HOH C . 
U 7 HOH 35  235  332 HOH HOH C . 
U 7 HOH 36  236  545 HOH HOH C . 
U 7 HOH 37  237  218 HOH HOH C . 
U 7 HOH 38  238  628 HOH HOH C . 
U 7 HOH 39  239  804 HOH HOH C . 
U 7 HOH 40  240  725 HOH HOH C . 
U 7 HOH 41  241  198 HOH HOH C . 
U 7 HOH 42  242  639 HOH HOH C . 
U 7 HOH 43  243  537 HOH HOH C . 
U 7 HOH 44  244  438 HOH HOH C . 
U 7 HOH 45  245  440 HOH HOH C . 
U 7 HOH 46  246  488 HOH HOH C . 
U 7 HOH 47  247  572 HOH HOH C . 
U 7 HOH 48  248  261 HOH HOH C . 
U 7 HOH 49  249  424 HOH HOH C . 
U 7 HOH 50  250  675 HOH HOH C . 
U 7 HOH 51  251  172 HOH HOH C . 
U 7 HOH 52  252  147 HOH HOH C . 
U 7 HOH 53  253  307 HOH HOH C . 
U 7 HOH 54  254  378 HOH HOH C . 
U 7 HOH 55  255  495 HOH HOH C . 
U 7 HOH 56  256  672 HOH HOH C . 
U 7 HOH 57  257  528 HOH HOH C . 
U 7 HOH 58  258  447 HOH HOH C . 
U 7 HOH 59  259  606 HOH HOH C . 
U 7 HOH 60  260  575 HOH HOH C . 
U 7 HOH 61  261  414 HOH HOH C . 
U 7 HOH 62  262  428 HOH HOH C . 
U 7 HOH 63  263  711 HOH HOH C . 
U 7 HOH 64  264  831 HOH HOH C . 
U 7 HOH 65  265  699 HOH HOH C . 
U 7 HOH 66  266  314 HOH HOH C . 
U 7 HOH 67  267  599 HOH HOH C . 
U 7 HOH 68  268  765 HOH HOH C . 
U 7 HOH 69  269  353 HOH HOH C . 
U 7 HOH 70  270  453 HOH HOH C . 
U 7 HOH 71  271  31  HOH HOH C . 
U 7 HOH 72  272  387 HOH HOH C . 
U 7 HOH 73  273  547 HOH HOH C . 
U 7 HOH 74  274  842 HOH HOH C . 
U 7 HOH 75  275  791 HOH HOH C . 
U 7 HOH 76  276  512 HOH HOH C . 
U 7 HOH 77  277  704 HOH HOH C . 
U 7 HOH 78  278  658 HOH HOH C . 
U 7 HOH 79  279  452 HOH HOH C . 
U 7 HOH 80  280  248 HOH HOH C . 
U 7 HOH 81  281  610 HOH HOH C . 
U 7 HOH 82  282  872 HOH HOH C . 
U 7 HOH 83  283  812 HOH HOH C . 
U 7 HOH 84  284  823 HOH HOH C . 
U 7 HOH 85  285  694 HOH HOH C . 
U 7 HOH 86  286  784 HOH HOH C . 
U 7 HOH 87  287  770 HOH HOH C . 
U 7 HOH 88  288  841 HOH HOH C . 
U 7 HOH 89  289  415 HOH HOH C . 
U 7 HOH 90  290  187 HOH HOH C . 
U 7 HOH 91  291  857 HOH HOH C . 
U 7 HOH 92  292  479 HOH HOH C . 
U 7 HOH 93  293  706 HOH HOH C . 
U 7 HOH 94  294  490 HOH HOH C . 
U 7 HOH 95  295  708 HOH HOH C . 
U 7 HOH 96  296  674 HOH HOH C . 
U 7 HOH 97  297  448 HOH HOH C . 
U 7 HOH 98  298  741 HOH HOH C . 
U 7 HOH 99  299  640 HOH HOH C . 
V 7 HOH 1   701  730 HOH HOH B . 
V 7 HOH 2   702  869 HOH HOH B . 
V 7 HOH 3   703  697 HOH HOH B . 
V 7 HOH 4   704  667 HOH HOH B . 
V 7 HOH 5   705  444 HOH HOH B . 
V 7 HOH 6   706  386 HOH HOH B . 
V 7 HOH 7   707  698 HOH HOH B . 
V 7 HOH 8   708  385 HOH HOH B . 
V 7 HOH 9   709  371 HOH HOH B . 
V 7 HOH 10  710  500 HOH HOH B . 
V 7 HOH 11  711  589 HOH HOH B . 
V 7 HOH 12  712  666 HOH HOH B . 
V 7 HOH 13  713  364 HOH HOH B . 
V 7 HOH 14  714  817 HOH HOH B . 
V 7 HOH 15  715  155 HOH HOH B . 
V 7 HOH 16  716  246 HOH HOH B . 
V 7 HOH 17  717  605 HOH HOH B . 
V 7 HOH 18  718  260 HOH HOH B . 
V 7 HOH 19  719  96  HOH HOH B . 
V 7 HOH 20  720  813 HOH HOH B . 
V 7 HOH 21  721  133 HOH HOH B . 
V 7 HOH 22  722  399 HOH HOH B . 
V 7 HOH 23  723  700 HOH HOH B . 
V 7 HOH 24  724  766 HOH HOH B . 
V 7 HOH 25  725  264 HOH HOH B . 
V 7 HOH 26  726  641 HOH HOH B . 
V 7 HOH 27  727  691 HOH HOH B . 
V 7 HOH 28  728  285 HOH HOH B . 
V 7 HOH 29  729  227 HOH HOH B . 
V 7 HOH 30  730  369 HOH HOH B . 
V 7 HOH 31  731  457 HOH HOH B . 
V 7 HOH 32  732  671 HOH HOH B . 
V 7 HOH 33  733  42  HOH HOH B . 
V 7 HOH 34  734  157 HOH HOH B . 
V 7 HOH 35  735  847 HOH HOH B . 
V 7 HOH 36  736  406 HOH HOH B . 
V 7 HOH 37  737  802 HOH HOH B . 
V 7 HOH 38  738  777 HOH HOH B . 
V 7 HOH 39  739  685 HOH HOH B . 
V 7 HOH 40  740  220 HOH HOH B . 
V 7 HOH 41  741  6   HOH HOH B . 
V 7 HOH 42  742  418 HOH HOH B . 
V 7 HOH 43  743  262 HOH HOH B . 
V 7 HOH 44  744  524 HOH HOH B . 
V 7 HOH 45  745  64  HOH HOH B . 
V 7 HOH 46  746  67  HOH HOH B . 
V 7 HOH 47  747  392 HOH HOH B . 
V 7 HOH 48  748  149 HOH HOH B . 
V 7 HOH 49  749  522 HOH HOH B . 
V 7 HOH 50  750  127 HOH HOH B . 
V 7 HOH 51  751  523 HOH HOH B . 
V 7 HOH 52  752  233 HOH HOH B . 
V 7 HOH 53  753  72  HOH HOH B . 
V 7 HOH 54  754  62  HOH HOH B . 
V 7 HOH 55  755  274 HOH HOH B . 
V 7 HOH 56  756  33  HOH HOH B . 
V 7 HOH 57  757  86  HOH HOH B . 
V 7 HOH 58  758  47  HOH HOH B . 
V 7 HOH 59  759  360 HOH HOH B . 
V 7 HOH 60  760  830 HOH HOH B . 
V 7 HOH 61  761  659 HOH HOH B . 
V 7 HOH 62  762  527 HOH HOH B . 
V 7 HOH 63  763  455 HOH HOH B . 
V 7 HOH 64  764  104 HOH HOH B . 
V 7 HOH 65  765  326 HOH HOH B . 
V 7 HOH 66  766  552 HOH HOH B . 
V 7 HOH 67  767  181 HOH HOH B . 
V 7 HOH 68  768  473 HOH HOH B . 
V 7 HOH 69  769  225 HOH HOH B . 
V 7 HOH 70  770  177 HOH HOH B . 
V 7 HOH 71  771  83  HOH HOH B . 
V 7 HOH 72  772  403 HOH HOH B . 
V 7 HOH 73  773  602 HOH HOH B . 
V 7 HOH 74  774  331 HOH HOH B . 
V 7 HOH 75  775  594 HOH HOH B . 
V 7 HOH 76  776  466 HOH HOH B . 
V 7 HOH 77  777  77  HOH HOH B . 
V 7 HOH 78  778  16  HOH HOH B . 
V 7 HOH 79  779  162 HOH HOH B . 
V 7 HOH 80  780  216 HOH HOH B . 
V 7 HOH 81  781  68  HOH HOH B . 
V 7 HOH 82  782  97  HOH HOH B . 
V 7 HOH 83  783  502 HOH HOH B . 
V 7 HOH 84  784  190 HOH HOH B . 
V 7 HOH 85  785  25  HOH HOH B . 
V 7 HOH 86  786  45  HOH HOH B . 
V 7 HOH 87  787  50  HOH HOH B . 
V 7 HOH 88  788  654 HOH HOH B . 
V 7 HOH 89  789  35  HOH HOH B . 
V 7 HOH 90  790  107 HOH HOH B . 
V 7 HOH 91  791  153 HOH HOH B . 
V 7 HOH 92  792  90  HOH HOH B . 
V 7 HOH 93  793  79  HOH HOH B . 
V 7 HOH 94  794  53  HOH HOH B . 
V 7 HOH 95  795  36  HOH HOH B . 
V 7 HOH 96  796  205 HOH HOH B . 
V 7 HOH 97  797  652 HOH HOH B . 
V 7 HOH 98  798  169 HOH HOH B . 
V 7 HOH 99  799  745 HOH HOH B . 
V 7 HOH 100 800  239 HOH HOH B . 
V 7 HOH 101 801  29  HOH HOH B . 
V 7 HOH 102 802  12  HOH HOH B . 
V 7 HOH 103 803  161 HOH HOH B . 
V 7 HOH 104 804  346 HOH HOH B . 
V 7 HOH 105 805  201 HOH HOH B . 
V 7 HOH 106 806  51  HOH HOH B . 
V 7 HOH 107 807  229 HOH HOH B . 
V 7 HOH 108 808  63  HOH HOH B . 
V 7 HOH 109 809  866 HOH HOH B . 
V 7 HOH 110 810  309 HOH HOH B . 
V 7 HOH 111 811  860 HOH HOH B . 
V 7 HOH 112 812  5   HOH HOH B . 
V 7 HOH 113 813  365 HOH HOH B . 
V 7 HOH 114 814  613 HOH HOH B . 
V 7 HOH 115 815  118 HOH HOH B . 
V 7 HOH 116 816  579 HOH HOH B . 
V 7 HOH 117 817  23  HOH HOH B . 
V 7 HOH 118 818  600 HOH HOH B . 
V 7 HOH 119 819  1   HOH HOH B . 
V 7 HOH 120 820  92  HOH HOH B . 
V 7 HOH 121 821  321 HOH HOH B . 
V 7 HOH 122 822  546 HOH HOH B . 
V 7 HOH 123 823  13  HOH HOH B . 
V 7 HOH 124 824  85  HOH HOH B . 
V 7 HOH 125 825  587 HOH HOH B . 
V 7 HOH 126 826  400 HOH HOH B . 
V 7 HOH 127 827  665 HOH HOH B . 
V 7 HOH 128 828  778 HOH HOH B . 
V 7 HOH 129 829  677 HOH HOH B . 
V 7 HOH 130 830  435 HOH HOH B . 
V 7 HOH 131 831  352 HOH HOH B . 
V 7 HOH 132 832  71  HOH HOH B . 
V 7 HOH 133 833  223 HOH HOH B . 
V 7 HOH 134 834  462 HOH HOH B . 
V 7 HOH 135 835  57  HOH HOH B . 
V 7 HOH 136 836  120 HOH HOH B . 
V 7 HOH 137 837  124 HOH HOH B . 
V 7 HOH 138 838  9   HOH HOH B . 
V 7 HOH 139 839  146 HOH HOH B . 
V 7 HOH 140 840  609 HOH HOH B . 
V 7 HOH 141 841  596 HOH HOH B . 
V 7 HOH 142 842  870 HOH HOH B . 
V 7 HOH 143 843  844 HOH HOH B . 
V 7 HOH 144 844  19  HOH HOH B . 
V 7 HOH 145 845  486 HOH HOH B . 
V 7 HOH 146 846  311 HOH HOH B . 
V 7 HOH 147 847  863 HOH HOH B . 
V 7 HOH 148 848  410 HOH HOH B . 
V 7 HOH 149 849  76  HOH HOH B . 
V 7 HOH 150 850  330 HOH HOH B . 
V 7 HOH 151 851  249 HOH HOH B . 
V 7 HOH 152 852  154 HOH HOH B . 
V 7 HOH 153 853  136 HOH HOH B . 
V 7 HOH 154 854  80  HOH HOH B . 
V 7 HOH 155 855  316 HOH HOH B . 
V 7 HOH 156 856  303 HOH HOH B . 
V 7 HOH 157 857  176 HOH HOH B . 
V 7 HOH 158 858  571 HOH HOH B . 
V 7 HOH 159 859  217 HOH HOH B . 
V 7 HOH 160 860  820 HOH HOH B . 
V 7 HOH 161 861  192 HOH HOH B . 
V 7 HOH 162 862  341 HOH HOH B . 
V 7 HOH 163 863  66  HOH HOH B . 
V 7 HOH 164 864  197 HOH HOH B . 
V 7 HOH 165 865  797 HOH HOH B . 
V 7 HOH 166 866  41  HOH HOH B . 
V 7 HOH 167 867  60  HOH HOH B . 
V 7 HOH 168 868  14  HOH HOH B . 
V 7 HOH 169 869  372 HOH HOH B . 
V 7 HOH 170 870  131 HOH HOH B . 
V 7 HOH 171 871  650 HOH HOH B . 
V 7 HOH 172 872  93  HOH HOH B . 
V 7 HOH 173 873  34  HOH HOH B . 
V 7 HOH 174 874  300 HOH HOH B . 
V 7 HOH 175 875  39  HOH HOH B . 
V 7 HOH 176 876  143 HOH HOH B . 
V 7 HOH 177 877  286 HOH HOH B . 
V 7 HOH 178 878  117 HOH HOH B . 
V 7 HOH 179 879  361 HOH HOH B . 
V 7 HOH 180 880  135 HOH HOH B . 
V 7 HOH 181 881  380 HOH HOH B . 
V 7 HOH 182 882  91  HOH HOH B . 
V 7 HOH 183 883  388 HOH HOH B . 
V 7 HOH 184 884  347 HOH HOH B . 
V 7 HOH 185 885  22  HOH HOH B . 
V 7 HOH 186 886  582 HOH HOH B . 
V 7 HOH 187 887  126 HOH HOH B . 
V 7 HOH 188 888  240 HOH HOH B . 
V 7 HOH 189 889  368 HOH HOH B . 
V 7 HOH 190 890  73  HOH HOH B . 
V 7 HOH 191 891  351 HOH HOH B . 
V 7 HOH 192 892  180 HOH HOH B . 
V 7 HOH 193 893  431 HOH HOH B . 
V 7 HOH 194 894  236 HOH HOH B . 
V 7 HOH 195 895  199 HOH HOH B . 
V 7 HOH 196 896  256 HOH HOH B . 
V 7 HOH 197 897  506 HOH HOH B . 
V 7 HOH 198 898  38  HOH HOH B . 
V 7 HOH 199 899  517 HOH HOH B . 
V 7 HOH 200 900  175 HOH HOH B . 
V 7 HOH 201 901  834 HOH HOH B . 
V 7 HOH 202 902  481 HOH HOH B . 
V 7 HOH 203 903  358 HOH HOH B . 
V 7 HOH 204 904  231 HOH HOH B . 
V 7 HOH 205 905  617 HOH HOH B . 
V 7 HOH 206 906  843 HOH HOH B . 
V 7 HOH 207 907  305 HOH HOH B . 
V 7 HOH 208 908  417 HOH HOH B . 
V 7 HOH 209 909  718 HOH HOH B . 
V 7 HOH 210 910  257 HOH HOH B . 
V 7 HOH 211 911  253 HOH HOH B . 
V 7 HOH 212 912  10  HOH HOH B . 
V 7 HOH 213 913  114 HOH HOH B . 
V 7 HOH 214 914  282 HOH HOH B . 
V 7 HOH 215 915  845 HOH HOH B . 
V 7 HOH 216 916  803 HOH HOH B . 
V 7 HOH 217 917  202 HOH HOH B . 
V 7 HOH 218 918  297 HOH HOH B . 
V 7 HOH 219 919  780 HOH HOH B . 
V 7 HOH 220 920  858 HOH HOH B . 
V 7 HOH 221 921  862 HOH HOH B . 
V 7 HOH 222 922  163 HOH HOH B . 
V 7 HOH 223 923  744 HOH HOH B . 
V 7 HOH 224 924  338 HOH HOH B . 
V 7 HOH 225 925  113 HOH HOH B . 
V 7 HOH 226 926  819 HOH HOH B . 
V 7 HOH 227 927  743 HOH HOH B . 
V 7 HOH 228 928  623 HOH HOH B . 
V 7 HOH 229 929  627 HOH HOH B . 
V 7 HOH 230 930  581 HOH HOH B . 
V 7 HOH 231 931  588 HOH HOH B . 
V 7 HOH 232 932  598 HOH HOH B . 
V 7 HOH 233 933  742 HOH HOH B . 
V 7 HOH 234 934  647 HOH HOH B . 
V 7 HOH 235 935  611 HOH HOH B . 
V 7 HOH 236 936  569 HOH HOH B . 
V 7 HOH 237 937  601 HOH HOH B . 
V 7 HOH 238 938  412 HOH HOH B . 
V 7 HOH 239 939  439 HOH HOH B . 
V 7 HOH 240 940  705 HOH HOH B . 
V 7 HOH 241 941  320 HOH HOH B . 
V 7 HOH 242 942  603 HOH HOH B . 
V 7 HOH 243 943  865 HOH HOH B . 
V 7 HOH 244 944  65  HOH HOH B . 
V 7 HOH 245 945  756 HOH HOH B . 
V 7 HOH 246 946  801 HOH HOH B . 
V 7 HOH 247 947  645 HOH HOH B . 
V 7 HOH 248 948  822 HOH HOH B . 
V 7 HOH 249 949  646 HOH HOH B . 
V 7 HOH 250 950  693 HOH HOH B . 
V 7 HOH 251 951  767 HOH HOH B . 
V 7 HOH 252 952  683 HOH HOH B . 
V 7 HOH 253 953  484 HOH HOH B . 
V 7 HOH 254 954  663 HOH HOH B . 
V 7 HOH 255 955  626 HOH HOH B . 
V 7 HOH 256 956  511 HOH HOH B . 
V 7 HOH 257 957  760 HOH HOH B . 
V 7 HOH 258 958  483 HOH HOH B . 
V 7 HOH 259 959  631 HOH HOH B . 
V 7 HOH 260 960  653 HOH HOH B . 
V 7 HOH 261 961  310 HOH HOH B . 
V 7 HOH 262 962  58  HOH HOH B . 
V 7 HOH 263 963  306 HOH HOH B . 
V 7 HOH 264 964  660 HOH HOH B . 
V 7 HOH 265 965  773 HOH HOH B . 
V 7 HOH 266 966  74  HOH HOH B . 
V 7 HOH 267 967  668 HOH HOH B . 
V 7 HOH 268 968  676 HOH HOH B . 
V 7 HOH 269 969  779 HOH HOH B . 
V 7 HOH 270 970  642 HOH HOH B . 
V 7 HOH 271 971  402 HOH HOH B . 
V 7 HOH 272 972  848 HOH HOH B . 
V 7 HOH 273 973  317 HOH HOH B . 
V 7 HOH 274 974  749 HOH HOH B . 
V 7 HOH 275 975  561 HOH HOH B . 
V 7 HOH 276 976  516 HOH HOH B . 
V 7 HOH 277 977  851 HOH HOH B . 
V 7 HOH 278 978  324 HOH HOH B . 
V 7 HOH 279 979  689 HOH HOH B . 
V 7 HOH 280 980  630 HOH HOH B . 
V 7 HOH 281 981  564 HOH HOH B . 
V 7 HOH 282 982  549 HOH HOH B . 
V 7 HOH 283 983  505 HOH HOH B . 
V 7 HOH 284 984  769 HOH HOH B . 
V 7 HOH 285 985  383 HOH HOH B . 
V 7 HOH 286 986  867 HOH HOH B . 
V 7 HOH 287 987  764 HOH HOH B . 
V 7 HOH 288 988  370 HOH HOH B . 
V 7 HOH 289 989  554 HOH HOH B . 
V 7 HOH 290 990  407 HOH HOH B . 
V 7 HOH 291 991  315 HOH HOH B . 
V 7 HOH 292 992  534 HOH HOH B . 
V 7 HOH 293 993  235 HOH HOH B . 
V 7 HOH 294 994  302 HOH HOH B . 
V 7 HOH 295 995  308 HOH HOH B . 
V 7 HOH 296 996  612 HOH HOH B . 
V 7 HOH 297 997  445 HOH HOH B . 
V 7 HOH 298 998  721 HOH HOH B . 
V 7 HOH 299 999  382 HOH HOH B . 
V 7 HOH 300 1000 701 HOH HOH B . 
V 7 HOH 301 1001 868 HOH HOH B . 
V 7 HOH 302 1002 758 HOH HOH B . 
V 7 HOH 303 1003 754 HOH HOH B . 
V 7 HOH 304 1004 776 HOH HOH B . 
V 7 HOH 305 1005 713 HOH HOH B . 
W 7 HOH 1   301  471 HOH HOH D . 
W 7 HOH 2   302  354 HOH HOH D . 
W 7 HOH 3   303  222 HOH HOH D . 
W 7 HOH 4   304  460 HOH HOH D . 
W 7 HOH 5   305  374 HOH HOH D . 
W 7 HOH 6   306  578 HOH HOH D . 
W 7 HOH 7   307  54  HOH HOH D . 
W 7 HOH 8   308  173 HOH HOH D . 
W 7 HOH 9   309  807 HOH HOH D . 
W 7 HOH 10  310  690 HOH HOH D . 
W 7 HOH 11  311  458 HOH HOH D . 
W 7 HOH 12  312  413 HOH HOH D . 
W 7 HOH 13  313  684 HOH HOH D . 
W 7 HOH 14  314  381 HOH HOH D . 
W 7 HOH 15  315  619 HOH HOH D . 
W 7 HOH 16  316  252 HOH HOH D . 
W 7 HOH 17  317  557 HOH HOH D . 
W 7 HOH 18  318  325 HOH HOH D . 
W 7 HOH 19  319  275 HOH HOH D . 
W 7 HOH 20  320  356 HOH HOH D . 
W 7 HOH 21  321  174 HOH HOH D . 
W 7 HOH 22  322  688 HOH HOH D . 
W 7 HOH 23  323  329 HOH HOH D . 
W 7 HOH 24  324  625 HOH HOH D . 
W 7 HOH 25  325  213 HOH HOH D . 
W 7 HOH 26  326  189 HOH HOH D . 
W 7 HOH 27  327  49  HOH HOH D . 
W 7 HOH 28  328  551 HOH HOH D . 
W 7 HOH 29  329  237 HOH HOH D . 
W 7 HOH 30  330  258 HOH HOH D . 
W 7 HOH 31  331  194 HOH HOH D . 
W 7 HOH 32  332  497 HOH HOH D . 
W 7 HOH 33  333  148 HOH HOH D . 
W 7 HOH 34  334  208 HOH HOH D . 
W 7 HOH 35  335  130 HOH HOH D . 
W 7 HOH 36  336  298 HOH HOH D . 
W 7 HOH 37  337  89  HOH HOH D . 
W 7 HOH 38  338  717 HOH HOH D . 
W 7 HOH 39  339  288 HOH HOH D . 
W 7 HOH 40  340  204 HOH HOH D . 
W 7 HOH 41  341  158 HOH HOH D . 
W 7 HOH 42  342  244 HOH HOH D . 
W 7 HOH 43  343  800 HOH HOH D . 
W 7 HOH 44  344  621 HOH HOH D . 
W 7 HOH 45  345  562 HOH HOH D . 
W 7 HOH 46  346  295 HOH HOH D . 
W 7 HOH 47  347  377 HOH HOH D . 
W 7 HOH 48  348  491 HOH HOH D . 
W 7 HOH 49  349  838 HOH HOH D . 
W 7 HOH 50  350  112 HOH HOH D . 
W 7 HOH 51  351  856 HOH HOH D . 
W 7 HOH 52  352  574 HOH HOH D . 
W 7 HOH 53  353  614 HOH HOH D . 
W 7 HOH 54  354  496 HOH HOH D . 
W 7 HOH 55  355  492 HOH HOH D . 
W 7 HOH 56  356  70  HOH HOH D . 
W 7 HOH 57  357  210 HOH HOH D . 
W 7 HOH 58  358  806 HOH HOH D . 
W 7 HOH 59  359  373 HOH HOH D . 
W 7 HOH 60  360  277 HOH HOH D . 
W 7 HOH 61  361  24  HOH HOH D . 
W 7 HOH 62  362  513 HOH HOH D . 
W 7 HOH 63  363  532 HOH HOH D . 
W 7 HOH 64  364  357 HOH HOH D . 
W 7 HOH 65  365  250 HOH HOH D . 
W 7 HOH 66  366  586 HOH HOH D . 
W 7 HOH 67  367  529 HOH HOH D . 
W 7 HOH 68  368  540 HOH HOH D . 
W 7 HOH 69  369  429 HOH HOH D . 
W 7 HOH 70  370  3   HOH HOH D . 
W 7 HOH 71  371  37  HOH HOH D . 
W 7 HOH 72  372  543 HOH HOH D . 
W 7 HOH 73  373  538 HOH HOH D . 
W 7 HOH 74  374  265 HOH HOH D . 
W 7 HOH 75  375  164 HOH HOH D . 
W 7 HOH 76  376  655 HOH HOH D . 
W 7 HOH 77  377  318 HOH HOH D . 
W 7 HOH 78  378  871 HOH HOH D . 
W 7 HOH 79  379  794 HOH HOH D . 
W 7 HOH 80  380  171 HOH HOH D . 
W 7 HOH 81  381  376 HOH HOH D . 
W 7 HOH 82  382  355 HOH HOH D . 
W 7 HOH 83  383  478 HOH HOH D . 
W 7 HOH 84  384  188 HOH HOH D . 
W 7 HOH 85  385  98  HOH HOH D . 
W 7 HOH 86  386  379 HOH HOH D . 
W 7 HOH 87  387  301 HOH HOH D . 
W 7 HOH 88  388  336 HOH HOH D . 
W 7 HOH 89  389  152 HOH HOH D . 
W 7 HOH 90  390  279 HOH HOH D . 
W 7 HOH 91  391  475 HOH HOH D . 
W 7 HOH 92  392  763 HOH HOH D . 
W 7 HOH 93  393  787 HOH HOH D . 
W 7 HOH 94  394  456 HOH HOH D . 
W 7 HOH 95  395  46  HOH HOH D . 
W 7 HOH 96  396  281 HOH HOH D . 
W 7 HOH 97  397  384 HOH HOH D . 
W 7 HOH 98  398  544 HOH HOH D . 
W 7 HOH 99  399  30  HOH HOH D . 
W 7 HOH 100 400  788 HOH HOH D . 
W 7 HOH 101 401  200 HOH HOH D . 
W 7 HOH 102 402  839 HOH HOH D . 
W 7 HOH 103 403  212 HOH HOH D . 
W 7 HOH 104 404  533 HOH HOH D . 
W 7 HOH 105 405  560 HOH HOH D . 
W 7 HOH 106 406  15  HOH HOH D . 
W 7 HOH 107 407  695 HOH HOH D . 
W 7 HOH 108 408  291 HOH HOH D . 
W 7 HOH 109 409  808 HOH HOH D . 
W 7 HOH 110 410  618 HOH HOH D . 
W 7 HOH 111 411  69  HOH HOH D . 
W 7 HOH 112 412  323 HOH HOH D . 
W 7 HOH 113 413  570 HOH HOH D . 
W 7 HOH 114 414  624 HOH HOH D . 
W 7 HOH 115 415  792 HOH HOH D . 
W 7 HOH 116 416  832 HOH HOH D . 
W 7 HOH 117 417  761 HOH HOH D . 
W 7 HOH 118 418  585 HOH HOH D . 
W 7 HOH 119 419  541 HOH HOH D . 
W 7 HOH 120 420  591 HOH HOH D . 
W 7 HOH 121 421  772 HOH HOH D . 
W 7 HOH 122 422  771 HOH HOH D . 
W 7 HOH 123 423  635 HOH HOH D . 
W 7 HOH 124 424  736 HOH HOH D . 
W 7 HOH 125 425  774 HOH HOH D . 
W 7 HOH 126 426  480 HOH HOH D . 
W 7 HOH 127 427  680 HOH HOH D . 
W 7 HOH 128 428  615 HOH HOH D . 
W 7 HOH 129 429  738 HOH HOH D . 
W 7 HOH 130 430  716 HOH HOH D . 
W 7 HOH 131 431  637 HOH HOH D . 
W 7 HOH 132 432  271 HOH HOH D . 
W 7 HOH 133 433  723 HOH HOH D . 
W 7 HOH 134 434  129 HOH HOH D . 
W 7 HOH 135 435  476 HOH HOH D . 
W 7 HOH 136 436  828 HOH HOH D . 
W 7 HOH 137 437  854 HOH HOH D . 
W 7 HOH 138 438  425 HOH HOH D . 
W 7 HOH 139 439  593 HOH HOH D . 
W 7 HOH 140 440  821 HOH HOH D . 
W 7 HOH 141 441  254 HOH HOH D . 
W 7 HOH 142 442  853 HOH HOH D . 
W 7 HOH 143 443  747 HOH HOH D . 
W 7 HOH 144 444  729 HOH HOH D . 
W 7 HOH 145 445  712 HOH HOH D . 
W 7 HOH 146 446  661 HOH HOH D . 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2023-03-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? MOSFLM  ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_pdbx_entry_details.entry_id                 8EN6 
_pdbx_entry_details.nonpolymer_details       ? 
_pdbx_entry_details.sequence_details         ? 
_pdbx_entry_details.compound_details         ? 
_pdbx_entry_details.source_details           ? 
_pdbx_entry_details.has_ligand_of_interest   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O3 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   GOL 
_pdbx_validate_close_contact.auth_seq_id_1    602 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O2 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   GOL 
_pdbx_validate_close_contact.auth_seq_id_2    604 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.15 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             B 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_1              269 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_2             B 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_2              269 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             OD1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             B 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_3              269 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                124.64 
_pdbx_validate_rmsd_angle.angle_target_value         118.30 
_pdbx_validate_rmsd_angle.angle_deviation            6.34 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.90 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 SER A 254 ? ? -142.16 19.25  
2  1 GLN A 260 ? ? -140.46 50.49  
3  1 ALA A 359 ? ? -141.86 58.56  
4  1 ARG A 373 ? ? -144.77 -12.12 
5  1 VAL A 386 ? ? -120.76 -52.65 
6  1 ALA C 91  ? ? 175.49  166.03 
7  1 HIS C 120 ? ? -64.85  4.27   
8  1 GLN B 260 ? ? -140.43 51.36  
9  1 ALA B 359 ? ? -143.14 56.96  
10 1 ARG B 373 ? ? -151.59 -9.94  
11 1 VAL B 386 ? ? -120.93 -51.87 
12 1 ASN D 76  ? ? 39.83   51.94  
13 1 SER D 119 ? ? -99.37  30.22  
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? B HOH 1004 ? 5.92 . 
2 1 O ? B HOH 1005 ? 6.88 . 
3 1 O ? D HOH 446  ? 5.83 . 
# 
_pdbx_unobs_or_zero_occ_residues.id               1 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_residues.polymer_flag     Y 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id     D 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id     HIS 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id      121 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_residues.label_asym_id    D 
_pdbx_unobs_or_zero_occ_residues.label_comp_id    HIS 
_pdbx_unobs_or_zero_occ_residues.label_seq_id     121 
# 
_pdbx_audit_support.funding_organization   'German Research Foundation (DFG)' 
_pdbx_audit_support.country                Germany 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 GLYCEROL             GOL 
4 'ISOPROPYL ALCOHOL'  IPA 
5 1,2-ETHANEDIOL       EDO 
6 'DIMETHYL SULFOXIDE' DMS 
7 water                HOH 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
