HEADER VIRAL PROTEIN/IMMUNE SYSTEM 23-NOV-22 8F9M TITLE HIV ENV GERMLINE TARGETING BG505_MD64_N332-GT5 SOSIP IN COMPLEX WITH TITLE 2 V3-GLYCAN POLYCLONAL FAB ISOLATED FROM IMMUNIZED WILD TYPE MICE, AND TITLE 3 NHP MONOCLONAL FAB RM20A3 COMPND MOL_ID: 1; COMPND 2 MOLECULE: BG505_MD64_N332-GT5 GP120; COMPND 3 CHAIN: A, E, F; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: RM20A3 FAB HEAVY CHAIN; COMPND 7 CHAIN: C, J, K; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: RM20A3 FAB LIGHT CHAIN; COMPND 11 CHAIN: D, M, N; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: BG505_MD64_N332-GT5 GP41; COMPND 15 CHAIN: B, G, I; COMPND 16 ENGINEERED: YES; COMPND 17 MOL_ID: 5; COMPND 18 MOLECULE: V3-GLYCAN EPITOPE POLYCLONAL FAB HEAVY CHAIN; COMPND 19 CHAIN: H; COMPND 20 MOL_ID: 6; COMPND 21 MOLECULE: V3-GLYCAN EPITOPE POLYCLONAL FAB LIGHT CHAIN; COMPND 22 CHAIN: L SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 3 ORGANISM_TAXID: 32630; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 9 ORGANISM_COMMON: RHESUS MONKEY; SOURCE 10 ORGANISM_TAXID: 9544; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 14 MOL_ID: 3; SOURCE 15 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 16 ORGANISM_COMMON: RHESUS MONKEY; SOURCE 17 ORGANISM_TAXID: 9544; SOURCE 18 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 19 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 21 MOL_ID: 4; SOURCE 22 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 23 ORGANISM_TAXID: 32630; SOURCE 24 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 25 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 27 MOL_ID: 5; SOURCE 28 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 29 ORGANISM_COMMON: MOUSE; SOURCE 30 ORGANISM_TAXID: 10090; SOURCE 31 MOL_ID: 6; SOURCE 32 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 33 ORGANISM_COMMON: MOUSE; SOURCE 34 ORGANISM_TAXID: 10090 KEYWDS MOUSE ANTIBODY, GERMLINE TARGETING, HIV-1, VACCINE DESIGN, KEYWDS 2 POLYCLONAL, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.OZOROWSKI,A.B.WARD JRNL AUTH Z.XIE,Y.C.LIN,J.M.STEICHEN,G.OZOROWSKI,S.KRATOCHVIL,R.RAY, JRNL AUTH 2 J.L.TORRES,A.LIGUORI,O.KALYUZHNIY,X.WANG,J.E.WARNER, JRNL AUTH 3 S.R.WELDON,G.A.DALE,K.H.KIRSCH,U.NAIR,S.BABOO,E.GEORGESON, JRNL AUTH 4 Y.ADACHI,M.KUBITZ,A.M.JACKSON,S.T.RICHEY,R.M.VOLK,J.H.LEE, JRNL AUTH 5 J.K.DIEDRICH,T.PRUM,S.FALCONE,S.HIMANSU,A.CARFI,J.R.YATES, JRNL AUTH 6 J.C.PAULSON,D.SOK,A.B.WARD,W.R.SCHIEF,F.D.BATISTA JRNL TITL MRNA-LNP HIV-1 TRIMER BOOSTERS ELICIT PRECURSORS TO BROAD JRNL TITL 2 NEUTRALIZING ANTIBODIES JRNL REF SCIENCE 2024 JRNL REFN ESSN 1095-9203 JRNL DOI 10.1126/SCIENCE.ADK0582 REMARK 2 REMARK 2 RESOLUTION. 4.10 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : EPU, CRYOSPARC, RELION, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.100 REMARK 3 NUMBER OF PARTICLES : 11058 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8F9M COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB. REMARK 100 THE DEPOSITION ID IS D_1000270241. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HIV ENV GERMLINE TARGETING REMARK 245 BG505_MD64_N332-GT5 SOSIP IN REMARK 245 COMPLEX WITH V3-GLYCAN REMARK 245 POLYCLONAL FAB ISOLATED FROM REMARK 245 IMMUNIZED WILD TYPE MICE, AND REMARK 245 NHP MONOCLONAL FAB RM20A3 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 7.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 40.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, D, B, E, J, M, G, F, K, REMARK 350 AND CHAINS: N, I, H, L, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA A 31 REMARK 465 GLU A 32 REMARK 465 ALA A 58 REMARK 465 LYS A 59 REMARK 465 ALA A 60 REMARK 465 TYR A 61 REMARK 465 GLU A 62 REMARK 465 THR A 63 REMARK 465 GLU A 64 REMARK 465 LYS A 65 REMARK 465 GLU A 185A REMARK 465 ASN A 185B REMARK 465 GLN A 185C REMARK 465 GLY A 185D REMARK 465 ASN A 185E REMARK 465 ARG A 185F REMARK 465 SER A 185G REMARK 465 ASN A 185H REMARK 465 ASN A 185I REMARK 465 SER A 185J REMARK 465 ASN A 185K REMARK 465 ASN A 399 REMARK 465 THR A 400 REMARK 465 SER A 401 REMARK 465 VAL A 402 REMARK 465 GLN A 403 REMARK 465 GLY A 404 REMARK 465 SER A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 THR A 408 REMARK 465 GLY A 409 REMARK 465 SER A 410 REMARK 465 ASN A 411 REMARK 465 GLY A 458 REMARK 465 GLY A 459 REMARK 465 SER A 460 REMARK 465 THR A 461 REMARK 465 ASN A 462 REMARK 465 VAL A 505 REMARK 465 VAL A 506 REMARK 465 GLY A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 SER C 112 REMARK 465 SER C 113 REMARK 465 THR D 105 REMARK 465 VAL D 106 REMARK 465 LEU D 107 REMARK 465 GLY D 108 REMARK 465 GLN D 109 REMARK 465 PRO D 110 REMARK 465 LYS D 111 REMARK 465 ALA D 112 REMARK 465 SER D 113 REMARK 465 PRO D 114 REMARK 465 THR D 115 REMARK 465 VAL D 116 REMARK 465 THR D 117 REMARK 465 LEU D 118 REMARK 465 PHE D 119 REMARK 465 PRO D 120 REMARK 465 PRO D 121 REMARK 465 SER D 122 REMARK 465 SER D 123 REMARK 465 GLU D 124 REMARK 465 GLU D 125 REMARK 465 LEU D 126 REMARK 465 ALA B 512 REMARK 465 VAL B 513 REMARK 465 GLY B 514 REMARK 465 ILE B 515 REMARK 465 GLY B 516 REMARK 465 ALA B 517 REMARK 465 VAL B 518 REMARK 465 SER B 519 REMARK 465 LEU B 520 REMARK 465 GLY B 547 REMARK 465 ILE B 548 REMARK 465 VAL B 549 REMARK 465 GLN B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 SER B 553 REMARK 465 ASN B 554 REMARK 465 LEU B 555 REMARK 465 LEU B 556 REMARK 465 ARG B 557 REMARK 465 ALA B 558 REMARK 465 PRO B 559 REMARK 465 GLU B 560 REMARK 465 PRO B 561 REMARK 465 GLN B 562 REMARK 465 GLN B 563 REMARK 465 HIS B 564 REMARK 465 LEU B 565 REMARK 465 LEU B 566 REMARK 465 LYS B 567 REMARK 465 ASP B 568 REMARK 465 THR B 569 REMARK 465 HIS B 570 REMARK 465 TRP B 571 REMARK 465 GLY B 665 REMARK 465 THR B 666 REMARK 465 LYS B 667 REMARK 465 HIS B 668 REMARK 465 HIS B 669 REMARK 465 HIS B 670 REMARK 465 HIS B 671 REMARK 465 HIS B 672 REMARK 465 HIS B 673 REMARK 465 ALA E 31 REMARK 465 GLU E 32 REMARK 465 ALA E 58 REMARK 465 LYS E 59 REMARK 465 ALA E 60 REMARK 465 TYR E 61 REMARK 465 GLU E 62 REMARK 465 THR E 63 REMARK 465 GLU E 64 REMARK 465 LYS E 65 REMARK 465 GLU E 185A REMARK 465 ASN E 185B REMARK 465 GLN E 185C REMARK 465 GLY E 185D REMARK 465 ASN E 185E REMARK 465 ARG E 185F REMARK 465 SER E 185G REMARK 465 ASN E 185H REMARK 465 ASN E 185I REMARK 465 SER E 185J REMARK 465 ASN E 399 REMARK 465 THR E 400 REMARK 465 SER E 401 REMARK 465 VAL E 402 REMARK 465 GLN E 403 REMARK 465 GLY E 404 REMARK 465 SER E 405 REMARK 465 ASN E 406 REMARK 465 SER E 407 REMARK 465 THR E 408 REMARK 465 GLY E 409 REMARK 465 SER E 410 REMARK 465 ASN E 411 REMARK 465 GLY E 458 REMARK 465 GLY E 459 REMARK 465 SER E 460 REMARK 465 THR E 461 REMARK 465 ASN E 462 REMARK 465 VAL E 505 REMARK 465 VAL E 506 REMARK 465 GLY E 507 REMARK 465 ARG E 508 REMARK 465 ARG E 509 REMARK 465 ARG E 510 REMARK 465 ARG E 511 REMARK 465 ARG E 512 REMARK 465 ARG E 513 REMARK 465 SER J 112 REMARK 465 SER J 113 REMARK 465 THR M 105 REMARK 465 VAL M 106 REMARK 465 LEU M 107 REMARK 465 GLY M 108 REMARK 465 GLN M 109 REMARK 465 PRO M 110 REMARK 465 LYS M 111 REMARK 465 ALA M 112 REMARK 465 SER M 113 REMARK 465 PRO M 114 REMARK 465 THR M 115 REMARK 465 VAL M 116 REMARK 465 THR M 117 REMARK 465 LEU M 118 REMARK 465 PHE M 119 REMARK 465 PRO M 120 REMARK 465 PRO M 121 REMARK 465 SER M 122 REMARK 465 SER M 123 REMARK 465 GLU M 124 REMARK 465 GLU M 125 REMARK 465 LEU M 126 REMARK 465 ALA G 512 REMARK 465 VAL G 513 REMARK 465 GLY G 514 REMARK 465 ILE G 515 REMARK 465 GLY G 516 REMARK 465 ALA G 517 REMARK 465 VAL G 518 REMARK 465 SER G 519 REMARK 465 LEU G 520 REMARK 465 GLY G 547 REMARK 465 ILE G 548 REMARK 465 VAL G 549 REMARK 465 GLN G 550 REMARK 465 GLN G 551 REMARK 465 GLN G 552 REMARK 465 SER G 553 REMARK 465 ASN G 554 REMARK 465 LEU G 555 REMARK 465 LEU G 556 REMARK 465 ARG G 557 REMARK 465 ALA G 558 REMARK 465 PRO G 559 REMARK 465 GLU G 560 REMARK 465 PRO G 561 REMARK 465 GLN G 562 REMARK 465 GLN G 563 REMARK 465 HIS G 564 REMARK 465 LEU G 565 REMARK 465 LEU G 566 REMARK 465 LYS G 567 REMARK 465 ASP G 568 REMARK 465 THR G 569 REMARK 465 HIS G 570 REMARK 465 TRP G 571 REMARK 465 GLY G 665 REMARK 465 THR G 666 REMARK 465 LYS G 667 REMARK 465 HIS G 668 REMARK 465 HIS G 669 REMARK 465 HIS G 670 REMARK 465 HIS G 671 REMARK 465 HIS G 672 REMARK 465 HIS G 673 REMARK 465 ALA F 31 REMARK 465 GLU F 32 REMARK 465 ALA F 58 REMARK 465 LYS F 59 REMARK 465 ALA F 60 REMARK 465 TYR F 61 REMARK 465 GLU F 62 REMARK 465 THR F 63 REMARK 465 GLU F 64 REMARK 465 LYS F 65 REMARK 465 GLU F 185A REMARK 465 ASN F 185B REMARK 465 GLN F 185C REMARK 465 GLY F 185D REMARK 465 ASN F 185E REMARK 465 ARG F 185F REMARK 465 SER F 185G REMARK 465 ASN F 185H REMARK 465 ASN F 185I REMARK 465 SER F 185J REMARK 465 ASN F 185K REMARK 465 ASN F 399 REMARK 465 THR F 400 REMARK 465 SER F 401 REMARK 465 VAL F 402 REMARK 465 GLN F 403 REMARK 465 GLY F 404 REMARK 465 SER F 405 REMARK 465 ASN F 406 REMARK 465 SER F 407 REMARK 465 THR F 408 REMARK 465 GLY F 409 REMARK 465 SER F 410 REMARK 465 ASN F 411 REMARK 465 GLY F 458 REMARK 465 GLY F 459 REMARK 465 SER F 460 REMARK 465 THR F 461 REMARK 465 ASN F 462 REMARK 465 VAL F 505 REMARK 465 VAL F 506 REMARK 465 GLY F 507 REMARK 465 ARG F 508 REMARK 465 ARG F 509 REMARK 465 ARG F 510 REMARK 465 ARG F 511 REMARK 465 ARG F 512 REMARK 465 ARG F 513 REMARK 465 SER K 112 REMARK 465 SER K 113 REMARK 465 THR N 105 REMARK 465 VAL N 106 REMARK 465 LEU N 107 REMARK 465 GLY N 108 REMARK 465 GLN N 109 REMARK 465 PRO N 110 REMARK 465 LYS N 111 REMARK 465 ALA N 112 REMARK 465 SER N 113 REMARK 465 PRO N 114 REMARK 465 THR N 115 REMARK 465 VAL N 116 REMARK 465 THR N 117 REMARK 465 LEU N 118 REMARK 465 PHE N 119 REMARK 465 PRO N 120 REMARK 465 PRO N 121 REMARK 465 SER N 122 REMARK 465 SER N 123 REMARK 465 GLU N 124 REMARK 465 GLU N 125 REMARK 465 LEU N 126 REMARK 465 ALA I 512 REMARK 465 VAL I 513 REMARK 465 GLY I 514 REMARK 465 ILE I 515 REMARK 465 GLY I 516 REMARK 465 ALA I 517 REMARK 465 VAL I 518 REMARK 465 SER I 519 REMARK 465 LEU I 520 REMARK 465 GLY I 547 REMARK 465 ILE I 548 REMARK 465 VAL I 549 REMARK 465 GLN I 550 REMARK 465 GLN I 551 REMARK 465 GLN I 552 REMARK 465 SER I 553 REMARK 465 ASN I 554 REMARK 465 LEU I 555 REMARK 465 LEU I 556 REMARK 465 ARG I 557 REMARK 465 ALA I 558 REMARK 465 PRO I 559 REMARK 465 GLU I 560 REMARK 465 PRO I 561 REMARK 465 GLN I 562 REMARK 465 GLN I 563 REMARK 465 HIS I 564 REMARK 465 LEU I 565 REMARK 465 LEU I 566 REMARK 465 LYS I 567 REMARK 465 ASP I 568 REMARK 465 THR I 569 REMARK 465 HIS I 570 REMARK 465 TRP I 571 REMARK 465 GLY I 665 REMARK 465 THR I 666 REMARK 465 LYS I 667 REMARK 465 HIS I 668 REMARK 465 HIS I 669 REMARK 465 HIS I 670 REMARK 465 HIS I 671 REMARK 465 HIS I 672 REMARK 465 HIS I 673 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 NH1 ARG F 350 O THR F 357 2.19 REMARK 500 O ALA A 266 ND2 ASN A 289 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 THR A 90 75.41 -118.20 REMARK 500 LEU A 138 148.41 -171.18 REMARK 500 MET A 161 -168.08 62.73 REMARK 500 GLN A 258 -45.66 68.87 REMARK 500 THR A 387 -5.82 68.78 REMARK 500 LYS C 43 -138.40 -140.29 REMARK 500 SER C 82B -31.64 75.75 REMARK 500 ALA C 100 -2.19 72.22 REMARK 500 ASP C 101 -63.08 -123.29 REMARK 500 ASP D 50 -176.66 63.65 REMARK 500 SER B 612 -14.33 78.20 REMARK 500 GLN E 258 -46.98 66.41 REMARK 500 PRO E 313 109.14 -56.43 REMARK 500 PHE E 391 57.35 -115.46 REMARK 500 SER E 393 148.60 -170.51 REMARK 500 ALA J 100 -38.87 64.63 REMARK 500 LYS J 100E -63.73 -128.99 REMARK 500 ASP M 50 -176.08 63.84 REMARK 500 SER G 612 -14.97 78.27 REMARK 500 THR F 162 -7.46 79.47 REMARK 500 THR F 163 -144.17 53.00 REMARK 500 GLN F 258 -49.53 64.57 REMARK 500 GLU F 268 -54.81 -123.42 REMARK 500 ARG K 66 -35.09 -132.59 REMARK 500 SER K 82B -44.82 76.55 REMARK 500 LYS K 100E -86.93 -117.06 REMARK 500 ASN N 31 51.92 -90.34 REMARK 500 VAL N 51 -55.12 70.34 REMARK 500 LEU I 523 16.29 58.73 REMARK 500 SER I 599 -128.87 49.53 REMARK 500 SER I 612 -14.00 78.32 REMARK 500 UNK H 5 -171.34 69.63 REMARK 500 UNK H 14 -3.73 80.63 REMARK 500 UNK H 26 -137.13 61.24 REMARK 500 UNK H 31 -131.26 54.14 REMARK 500 UNK H 52 -129.27 56.95 REMARK 500 UNK H 55 4.48 83.22 REMARK 500 UNK H 59 -59.34 -137.33 REMARK 500 UNK H 60 -175.15 175.33 REMARK 500 UNK H 64 -53.91 69.58 REMARK 500 UNK H 83 173.97 83.71 REMARK 500 UNK H 84 173.20 78.71 REMARK 500 UNK H 100 16.93 80.92 REMARK 500 UNK H 101 3.27 83.73 REMARK 500 UNK H 108 -179.93 77.37 REMARK 500 UNK L 7 -135.45 51.46 REMARK 500 UNK L 8 -146.81 -115.13 REMARK 500 UNK L 15 169.80 178.28 REMARK 500 UNK L 30 -161.94 -127.67 REMARK 500 UNK L 31 31.65 -74.83 REMARK 500 REMARK 500 THIS ENTRY HAS 61 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-28945 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-28942 RELATED DB: EMDB DBREF 8F9M A 31 513 PDB 8F9M 8F9M 31 513 DBREF 8F9M C 1 113 PDB 8F9M 8F9M 1 113 DBREF 8F9M D 3 126 PDB 8F9M 8F9M 3 126 DBREF 8F9M B 512 673 PDB 8F9M 8F9M 512 673 DBREF 8F9M E 31 513 PDB 8F9M 8F9M 31 513 DBREF 8F9M J 1 113 PDB 8F9M 8F9M 1 113 DBREF 8F9M M 3 126 PDB 8F9M 8F9M 3 126 DBREF 8F9M G 512 673 PDB 8F9M 8F9M 512 673 DBREF 8F9M F 31 513 PDB 8F9M 8F9M 31 513 DBREF 8F9M K 1 113 PDB 8F9M 8F9M 1 113 DBREF 8F9M N 3 126 PDB 8F9M 8F9M 3 126 DBREF 8F9M I 512 673 PDB 8F9M 8F9M 512 673 DBREF 8F9M H 1 113 PDB 8F9M 8F9M 1 113 DBREF 8F9M L 1 110 PDB 8F9M 8F9M 1 110 SEQRES 1 A 481 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 A 481 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 A 481 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 A 481 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 A 481 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 A 481 TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP ILE SEQRES 7 A 481 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 A 481 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN TYR SEQRES 9 A 481 ALA PRO LYS LEU ARG SER MET MET ARG GLY GLU ILE LYS SEQRES 10 A 481 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 A 481 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 A 481 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 A 481 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 A 481 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 A 481 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 A 481 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 A 481 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 A 481 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 A 481 LEU ALA GLU GLU GLU VAL ILE ILE ARG SER GLU ASN ILE SEQRES 20 A 481 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN LEU ASN THR SEQRES 21 A 481 PRO VAL GLN ILE ASN CYS THR ARG PRO SER ASN ASN THR SEQRES 22 A 481 VAL LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 A 481 TYR PHE GLY ASP VAL LEU GLY HIS VAL ARG MET ALA HIS SEQRES 24 A 481 CYS ASN ILE SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 A 481 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 A 481 THR ILE ILE ARG PHE ALA GLN SER SER GLY GLY ASP LEU SEQRES 27 A 481 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 A 481 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 A 481 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 A 481 SER ASN ASP SER LEU ILE LEU PRO CYS TRP ILE LYS GLN SEQRES 31 A 481 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR SEQRES 32 A 481 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 A 481 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 A 481 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 A 481 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 A 481 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 A 481 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 C 125 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY LEU VAL GLN SEQRES 2 C 125 PRO GLY GLY SER LEU LYS LEU SER CYS ARG ALA SER GLY SEQRES 3 C 125 TYR THR PHE SER SER PHE ALA MET SER TRP VAL ARG GLN SEQRES 4 C 125 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER LEU ILE ASN SEQRES 5 C 125 ASP ARG GLY GLY LEU THR PHE TYR VAL ASP SER VAL LYS SEQRES 6 C 125 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 C 125 LEU SER LEU GLN MET HIS SER LEU ARG ASP GLY ASP THR SEQRES 8 C 125 ALA VAL TYR TYR CYS ALA THR GLY GLY MET SER SER ALA SEQRES 9 C 125 LEU GLN SER SER LYS TYR TYR PHE ASP PHE TRP GLY GLN SEQRES 10 C 125 GLY ALA LEU VAL THR VAL SER SER SEQRES 1 D 128 ALA LEU THR GLN PRO PRO SER VAL SER GLY SER PRO GLY SEQRES 2 D 128 GLN SER VAL THR ILE SER CYS THR GLY THR SER SER ASP SEQRES 3 D 128 ILE GLY SER TYR ASN TYR VAL SER TRP TYR GLN GLN HIS SEQRES 4 D 128 PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP VAL THR SEQRES 5 D 128 GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SER SEQRES 6 D 128 LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY LEU SEQRES 7 D 128 GLN ALA ASP ASP GLU ALA ASP TYR TYR CYS SER ALA TYR SEQRES 8 D 128 ALA GLY ARG GLN THR PHE TYR ILE PHE GLY GLY GLY THR SEQRES 9 D 128 ARG LEU THR VAL LEU GLY GLN PRO LYS ALA SER PRO THR SEQRES 10 D 128 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 1 B 162 ALA VAL GLY ILE GLY ALA VAL SER LEU GLY PHE LEU GLY SEQRES 2 B 162 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 B 162 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 162 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU PRO GLN GLN SEQRES 5 B 162 HIS LEU LEU LYS ASP THR HIS TRP GLY ILE LYS GLN LEU SEQRES 6 B 162 GLN ALA ARG VAL LEU ALA VAL GLU HIS TYR LEU ARG ASP SEQRES 7 B 162 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 B 162 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 B 162 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 B 162 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 B 162 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 B 162 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP GLY THR LYS SEQRES 13 B 162 HIS HIS HIS HIS HIS HIS SEQRES 1 E 481 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 E 481 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 E 481 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 E 481 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 E 481 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 E 481 TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP ILE SEQRES 7 E 481 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 E 481 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN TYR SEQRES 9 E 481 ALA PRO LYS LEU ARG SER MET MET ARG GLY GLU ILE LYS SEQRES 10 E 481 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 E 481 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 E 481 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 E 481 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 E 481 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 E 481 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 E 481 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 E 481 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 E 481 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 E 481 LEU ALA GLU GLU GLU VAL ILE ILE ARG SER GLU ASN ILE SEQRES 20 E 481 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN LEU ASN THR SEQRES 21 E 481 PRO VAL GLN ILE ASN CYS THR ARG PRO SER ASN ASN THR SEQRES 22 E 481 VAL LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 E 481 TYR PHE GLY ASP VAL LEU GLY HIS VAL ARG MET ALA HIS SEQRES 24 E 481 CYS ASN ILE SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 E 481 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 E 481 THR ILE ILE ARG PHE ALA GLN SER SER GLY GLY ASP LEU SEQRES 27 E 481 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 E 481 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 E 481 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 E 481 SER ASN ASP SER LEU ILE LEU PRO CYS TRP ILE LYS GLN SEQRES 31 E 481 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR SEQRES 32 E 481 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 E 481 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 E 481 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 E 481 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 E 481 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 E 481 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 J 125 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY LEU VAL GLN SEQRES 2 J 125 PRO GLY GLY SER LEU LYS LEU SER CYS ARG ALA SER GLY SEQRES 3 J 125 TYR THR PHE SER SER PHE ALA MET SER TRP VAL ARG GLN SEQRES 4 J 125 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER LEU ILE ASN SEQRES 5 J 125 ASP ARG GLY GLY LEU THR PHE TYR VAL ASP SER VAL LYS SEQRES 6 J 125 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 J 125 LEU SER LEU GLN MET HIS SER LEU ARG ASP GLY ASP THR SEQRES 8 J 125 ALA VAL TYR TYR CYS ALA THR GLY GLY MET SER SER ALA SEQRES 9 J 125 LEU GLN SER SER LYS TYR TYR PHE ASP PHE TRP GLY GLN SEQRES 10 J 125 GLY ALA LEU VAL THR VAL SER SER SEQRES 1 M 128 ALA LEU THR GLN PRO PRO SER VAL SER GLY SER PRO GLY SEQRES 2 M 128 GLN SER VAL THR ILE SER CYS THR GLY THR SER SER ASP SEQRES 3 M 128 ILE GLY SER TYR ASN TYR VAL SER TRP TYR GLN GLN HIS SEQRES 4 M 128 PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP VAL THR SEQRES 5 M 128 GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SER SEQRES 6 M 128 LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY LEU SEQRES 7 M 128 GLN ALA ASP ASP GLU ALA ASP TYR TYR CYS SER ALA TYR SEQRES 8 M 128 ALA GLY ARG GLN THR PHE TYR ILE PHE GLY GLY GLY THR SEQRES 9 M 128 ARG LEU THR VAL LEU GLY GLN PRO LYS ALA SER PRO THR SEQRES 10 M 128 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 1 G 162 ALA VAL GLY ILE GLY ALA VAL SER LEU GLY PHE LEU GLY SEQRES 2 G 162 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 G 162 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 G 162 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU PRO GLN GLN SEQRES 5 G 162 HIS LEU LEU LYS ASP THR HIS TRP GLY ILE LYS GLN LEU SEQRES 6 G 162 GLN ALA ARG VAL LEU ALA VAL GLU HIS TYR LEU ARG ASP SEQRES 7 G 162 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 G 162 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 G 162 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 G 162 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 G 162 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 G 162 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP GLY THR LYS SEQRES 13 G 162 HIS HIS HIS HIS HIS HIS SEQRES 1 F 481 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 F 481 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 F 481 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 F 481 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 F 481 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 F 481 TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP ILE SEQRES 7 F 481 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 F 481 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN TYR SEQRES 9 F 481 ALA PRO LYS LEU ARG SER MET MET ARG GLY GLU ILE LYS SEQRES 10 F 481 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 F 481 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 F 481 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 F 481 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 F 481 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 F 481 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 F 481 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 F 481 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 F 481 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 F 481 LEU ALA GLU GLU GLU VAL ILE ILE ARG SER GLU ASN ILE SEQRES 20 F 481 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN LEU ASN THR SEQRES 21 F 481 PRO VAL GLN ILE ASN CYS THR ARG PRO SER ASN ASN THR SEQRES 22 F 481 VAL LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 F 481 TYR PHE GLY ASP VAL LEU GLY HIS VAL ARG MET ALA HIS SEQRES 24 F 481 CYS ASN ILE SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 F 481 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 F 481 THR ILE ILE ARG PHE ALA GLN SER SER GLY GLY ASP LEU SEQRES 27 F 481 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 F 481 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 F 481 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 F 481 SER ASN ASP SER LEU ILE LEU PRO CYS TRP ILE LYS GLN SEQRES 31 F 481 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR SEQRES 32 F 481 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 F 481 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 F 481 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 F 481 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 F 481 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 F 481 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 K 125 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY LEU VAL GLN SEQRES 2 K 125 PRO GLY GLY SER LEU LYS LEU SER CYS ARG ALA SER GLY SEQRES 3 K 125 TYR THR PHE SER SER PHE ALA MET SER TRP VAL ARG GLN SEQRES 4 K 125 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER LEU ILE ASN SEQRES 5 K 125 ASP ARG GLY GLY LEU THR PHE TYR VAL ASP SER VAL LYS SEQRES 6 K 125 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 K 125 LEU SER LEU GLN MET HIS SER LEU ARG ASP GLY ASP THR SEQRES 8 K 125 ALA VAL TYR TYR CYS ALA THR GLY GLY MET SER SER ALA SEQRES 9 K 125 LEU GLN SER SER LYS TYR TYR PHE ASP PHE TRP GLY GLN SEQRES 10 K 125 GLY ALA LEU VAL THR VAL SER SER SEQRES 1 N 128 ALA LEU THR GLN PRO PRO SER VAL SER GLY SER PRO GLY SEQRES 2 N 128 GLN SER VAL THR ILE SER CYS THR GLY THR SER SER ASP SEQRES 3 N 128 ILE GLY SER TYR ASN TYR VAL SER TRP TYR GLN GLN HIS SEQRES 4 N 128 PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP VAL THR SEQRES 5 N 128 GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SER SEQRES 6 N 128 LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY LEU SEQRES 7 N 128 GLN ALA ASP ASP GLU ALA ASP TYR TYR CYS SER ALA TYR SEQRES 8 N 128 ALA GLY ARG GLN THR PHE TYR ILE PHE GLY GLY GLY THR SEQRES 9 N 128 ARG LEU THR VAL LEU GLY GLN PRO LYS ALA SER PRO THR SEQRES 10 N 128 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 1 I 162 ALA VAL GLY ILE GLY ALA VAL SER LEU GLY PHE LEU GLY SEQRES 2 I 162 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 I 162 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 I 162 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU PRO GLN GLN SEQRES 5 I 162 HIS LEU LEU LYS ASP THR HIS TRP GLY ILE LYS GLN LEU SEQRES 6 I 162 GLN ALA ARG VAL LEU ALA VAL GLU HIS TYR LEU ARG ASP SEQRES 7 I 162 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 I 162 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 I 162 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 I 162 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 I 162 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 I 162 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP GLY THR LYS SEQRES 13 I 162 HIS HIS HIS HIS HIS HIS SEQRES 1 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 2 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 3 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 4 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 5 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 6 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 7 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 8 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 9 H 113 UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 1 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 2 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 3 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 4 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 5 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 6 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 7 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 8 L 110 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK SEQRES 9 L 110 UNK UNK UNK UNK UNK UNK HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG A 604 14 HET NAG A 605 14 HET NAG A 606 14 HET NAG A 607 14 HET NAG A 608 14 HET NAG A 609 14 HET NAG A 610 14 HET NAG B 701 14 HET NAG B 702 14 HET NAG B 703 14 HET NAG E 601 14 HET NAG E 602 14 HET NAG E 603 14 HET NAG E 604 14 HET NAG E 605 14 HET NAG E 606 14 HET NAG E 607 14 HET NAG E 608 14 HET NAG E 609 14 HET NAG E 610 14 HET NAG E 611 14 HET NAG G 701 14 HET NAG G 702 14 HET NAG G 703 14 HET NAG F 601 14 HET NAG F 602 14 HET NAG F 603 14 HET NAG F 604 14 HET NAG F 605 14 HET NAG F 606 14 HET NAG F 607 14 HET NAG F 608 14 HET NAG F 609 14 HET NAG F 610 14 HET NAG F 611 14 HET NAG F 612 14 HET NAG I 701 14 HET NAG I 702 14 HET NAG I 703 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET BMA Q 3 11 HET MAN Q 4 11 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET MAN T 4 11 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 15 NAG 60(C8 H15 N O6) FORMUL 59 BMA 2(C6 H12 O6) FORMUL 59 MAN 2(C6 H12 O6) HELIX 1 AA1 ASN A 99 LEU A 116 1 18 HELIX 2 AA2 LEU A 122 CYS A 126 5 5 HELIX 3 AA3 ASN A 195 THR A 198 5 4 HELIX 4 AA4 LYS A 335 GLY A 354 1 20 HELIX 5 AA5 ASP A 368 THR A 373 1 6 HELIX 6 AA6 THR A 387 PHE A 391 5 5 HELIX 7 AA7 ASN A 425 ARG A 429 5 5 HELIX 8 AA8 MET A 475 TYR A 484 1 10 HELIX 9 AA9 THR C 28 PHE C 32 5 5 HELIX 10 AB1 ARG C 83 THR C 87 5 5 HELIX 11 AB2 THR D 26 TYR D 30 1 8 HELIX 12 AB3 GLN D 79 GLU D 83 5 5 HELIX 13 AB4 THR B 529 SER B 534 1 6 HELIX 14 AB5 THR B 536 ASN B 543 1 8 HELIX 15 AB6 ILE B 573 TRP B 596 1 24 HELIX 16 AB7 ASN B 618 ASN B 625 1 8 HELIX 17 AB8 THR B 627 ILE B 635 1 9 HELIX 18 AB9 TYR B 638 ALA B 662 1 25 HELIX 19 AC1 ASN E 99 LYS E 117 1 19 HELIX 20 AC2 LEU E 122 CYS E 126 5 5 HELIX 21 AC3 ILE E 194 SER E 199 1 6 HELIX 22 AC4 LYS E 335 GLY E 354 1 20 HELIX 23 AC5 ASP E 368 THR E 373 1 6 HELIX 24 AC6 ASN E 425 ARG E 429 5 5 HELIX 25 AC7 ASP E 474 TYR E 484 1 11 HELIX 26 AC8 THR J 28 PHE J 32 5 5 HELIX 27 AC9 VAL J 60 GLY J 65 1 6 HELIX 28 AD1 ARG J 83 THR J 87 5 5 HELIX 29 AD2 THR M 26 TYR M 30 1 8 HELIX 30 AD3 GLN M 79 GLU M 83 5 5 HELIX 31 AD4 LEU G 523 SER G 528 5 6 HELIX 32 AD5 THR G 529 SER G 534 1 6 HELIX 33 AD6 THR G 536 ASN G 543 1 8 HELIX 34 AD7 ILE G 573 TRP G 596 1 24 HELIX 35 AD8 ASN G 618 ASN G 625 1 8 HELIX 36 AD9 THR G 627 ILE G 635 1 9 HELIX 37 AE1 TYR G 638 ALA G 662 1 25 HELIX 38 AE2 TRP F 96 ASN F 98 5 3 HELIX 39 AE3 ASN F 99 LYS F 117 1 19 HELIX 40 AE4 ASN F 195 THR F 198 5 4 HELIX 41 AE5 LYS F 335 GLY F 354 1 20 HELIX 42 AE6 ASP F 368 THR F 373 1 6 HELIX 43 AE7 THR F 387 PHE F 391 5 5 HELIX 44 AE8 ASN F 425 ARG F 429 5 5 HELIX 45 AE9 ASP F 474 TYR F 484 1 11 HELIX 46 AF1 THR K 28 PHE K 32 5 5 HELIX 47 AF2 ARG K 83 THR K 87 5 5 HELIX 48 AF3 THR N 26 TYR N 30 1 8 HELIX 49 AF4 GLN N 79 GLU N 83 5 5 HELIX 50 AF5 THR I 529 SER I 534 1 6 HELIX 51 AF6 THR I 536 LEU I 544 1 9 HELIX 52 AF7 ILE I 573 TRP I 596 1 24 HELIX 53 AF8 ASN I 618 ASN I 625 1 8 HELIX 54 AF9 THR I 627 ILE I 635 1 9 HELIX 55 AG1 TYR I 638 ALA I 662 1 25 SHEET 1 AA1 3 LEU A 494 THR A 499 0 SHEET 2 AA1 3 TRP A 35 TYR A 40 -1 N TYR A 39 O GLY A 495 SHEET 3 AA1 3 ILE B 603 PRO B 609 -1 O VAL B 608 N VAL A 36 SHEET 1 AA2 5 TRP A 45 ASP A 47 0 SHEET 2 AA2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AA2 5 PHE A 223 LYS A 227 -1 N LEU A 226 O LYS A 487 SHEET 4 AA2 5 SER A 243 VAL A 245 -1 O SER A 243 N LYS A 227 SHEET 5 AA2 5 GLU A 83 HIS A 85 -1 N ILE A 84 O THR A 244 SHEET 1 AA3 2 PHE A 53 ALA A 55 0 SHEET 2 AA3 2 HIS A 216 CYS A 218 -1 O CYS A 218 N PHE A 53 SHEET 1 AA4 2 GLU A 92 ASN A 94 0 SHEET 2 AA4 2 THR A 236 PRO A 238 -1 O GLY A 237 N PHE A 93 SHEET 1 AA5 5 VAL A 172 TYR A 177 0 SHEET 2 AA5 5 ILE A 154 PHE A 159 -1 N LYS A 155 O PHE A 176 SHEET 3 AA5 5 LEU A 129 ASN A 133 -1 N GLN A 130 O SER A 158 SHEET 4 AA5 5 GLU A 190 LEU A 193 -1 O TYR A 191 N LEU A 129 SHEET 5 AA5 5 VAL A 181 GLN A 183 -1 N VAL A 182 O ARG A 192 SHEET 1 AA6 3 ALA A 200 GLN A 203 0 SHEET 2 AA6 3 GLN A 432 TYR A 435 1 O TYR A 435 N THR A 202 SHEET 3 AA6 3 ILE A 423 ILE A 424 -1 N ILE A 424 O MET A 434 SHEET 1 AA712 LEU A 259 LEU A 261 0 SHEET 2 AA712 ILE A 271 ARG A 273 0 SHEET 3 AA712 ASN A 283 GLY A 312 -1 O LEU A 285 N ARG A 273 SHEET 4 AA712 GLN A 315 VAL A 323 -1 O TYR A 319 N LYS A 305 SHEET 5 AA712 ALA A 329 SER A 334 -1 O ASN A 332 N ASN A 295 SHEET 6 AA712 ILE A 358 PHE A 361 0 SHEET 7 AA712 HIS A 374 CYS A 378 0 SHEET 8 AA712 GLU A 381 CYS A 385 -1 O CYS A 385 N HIS A 374 SHEET 9 AA712 SER A 393 TRP A 395 -1 O TRP A 395 N ILE A 359 SHEET 10 AA712 SER A 413 LYS A 421 -1 O TRP A 419 N TYR A 384 SHEET 11 AA712 GLY A 441 ARG A 456 -1 O GLY A 441 N ASN A 302 SHEET 12 AA712 THR A 465 ARG A 469 -1 O ARG A 469 N THR A 455 SHEET 1 AA8 4 GLN C 3 THR C 7 0 SHEET 2 AA8 4 SER C 17 SER C 25 -1 O ARG C 23 N VAL C 5 SHEET 3 AA8 4 THR C 77 HIS C 82A-1 O MET C 82 N LEU C 18 SHEET 4 AA8 4 PHE C 67 ASP C 72 -1 N SER C 70 O SER C 79 SHEET 1 AA9 6 MET C 34 GLN C 39 0 SHEET 2 AA9 6 LEU C 45 ILE C 51 -1 O GLU C 46 N ARG C 38 SHEET 3 AA9 6 THR C 57 TYR C 59 -1 O PHE C 58 N LEU C 50 SHEET 4 AA9 6 ALA C 88 GLY C 95 -1 O TYR C 91 N VAL C 37 SHEET 5 AA9 6 PHE C 100H TRP C 103 -1 O PHE C 102 N THR C 94 SHEET 6 AA9 6 ALA C 107 VAL C 109 -1 O ALA C 107 N TYR C 90 SHEET 1 AB1 3 VAL D 19 THR D 24 0 SHEET 2 AB1 3 THR D 70 ILE D 75 -1 O ILE D 75 N VAL D 19 SHEET 3 AB1 3 PHE D 62 SER D 67 -1 N SER D 63 O THR D 74 SHEET 1 AB2 5 VAL D 33 GLN D 38 0 SHEET 2 AB2 5 PRO D 44 ILE D 48 -1 O LYS D 45 N GLN D 37 SHEET 3 AB2 5 ASP D 85 TYR D 91 -1 O ASP D 85 N GLN D 38 SHEET 4 AB2 5 TYR D 96 PHE D 98 -1 O ILE D 97 N ALA D 90 SHEET 5 AB2 5 THR D 102 ARG D 103 -1 O THR D 102 N TYR D 86 SHEET 1 AB3 3 LEU E 494 THR E 499 0 SHEET 2 AB3 3 TRP E 35 TYR E 40 -1 N TYR E 39 O GLY E 495 SHEET 3 AB3 3 ILE G 603 PRO G 609 -1 O CYS G 604 N VAL E 38 SHEET 1 AB4 5 TRP E 45 ASP E 47 0 SHEET 2 AB4 5 TYR E 486 ILE E 491 -1 O LYS E 490 N LYS E 46 SHEET 3 AB4 5 PHE E 223 LYS E 227 -1 N LEU E 226 O LYS E 487 SHEET 4 AB4 5 SER E 243 VAL E 245 -1 O VAL E 245 N ILE E 225 SHEET 5 AB4 5 GLU E 83 HIS E 85 -1 N ILE E 84 O THR E 244 SHEET 1 AB5 2 PHE E 53 ALA E 55 0 SHEET 2 AB5 2 HIS E 216 CYS E 218 -1 O CYS E 218 N PHE E 53 SHEET 1 AB6 2 GLU E 91 ASN E 94 0 SHEET 2 AB6 2 THR E 236 CYS E 239 -1 O GLY E 237 N PHE E 93 SHEET 1 AB7 5 LYS E 169 TYR E 177 0 SHEET 2 AB7 5 ILE E 154 THR E 162 -1 N PHE E 159 O VAL E 172 SHEET 3 AB7 5 LEU E 129 ASN E 133 -1 N GLN E 130 O SER E 158 SHEET 4 AB7 5 LYS E 189 LEU E 193 -1 O LYS E 189 N CYS E 131 SHEET 5 AB7 5 VAL E 181 GLN E 183 -1 N VAL E 182 O ARG E 192 SHEET 1 AB8 3 ILE E 201 GLN E 203 0 SHEET 2 AB8 3 ALA E 433 TYR E 435 1 O TYR E 435 N THR E 202 SHEET 3 AB8 3 ILE E 423 ILE E 424 -1 N ILE E 424 O MET E 434 SHEET 1 AB912 LEU E 259 LEU E 261 0 SHEET 2 AB912 ILE E 271 ARG E 273 0 SHEET 3 AB912 ILE E 284 GLY E 312 -1 O LEU E 285 N ARG E 273 SHEET 4 AB912 GLN E 315 VAL E 323 -1 O GLY E 321 N THR E 303 SHEET 5 AB912 ALA E 329 SER E 334 -1 O ASN E 332 N ASN E 295 SHEET 6 AB912 ILE E 358 PHE E 361 0 SHEET 7 AB912 HIS E 374 CYS E 378 0 SHEET 8 AB912 GLU E 381 CYS E 385 -1 O GLU E 381 N CYS E 378 SHEET 9 AB912 SER E 393 TRP E 395 -1 O TRP E 395 N ILE E 359 SHEET 10 AB912 SER E 413 ILE E 420 -1 O TRP E 419 N TYR E 384 SHEET 11 AB912 GLY E 441 ARG E 456 -1 O LEU E 454 N ILE E 284 SHEET 12 AB912 THR E 465 ARG E 469 -1 O ARG E 469 N THR E 455 SHEET 1 AC1 4 GLN J 3 THR J 7 0 SHEET 2 AC1 4 SER J 17 SER J 25 -1 O SER J 21 N THR J 7 SHEET 3 AC1 4 THR J 77 HIS J 82A-1 O MET J 82 N LEU J 18 SHEET 4 AC1 4 PHE J 67 ASP J 72 -1 N ASP J 72 O THR J 77 SHEET 1 AC2 6 MET J 34 GLN J 39 0 SHEET 2 AC2 6 LEU J 45 ILE J 51 -1 O GLU J 46 N ARG J 38 SHEET 3 AC2 6 THR J 57 TYR J 59 -1 O PHE J 58 N LEU J 50 SHEET 4 AC2 6 ALA J 88 GLY J 95 -1 O ALA J 93 N SER J 35 SHEET 5 AC2 6 PHE J 100H TRP J 103 -1 O PHE J 102 N THR J 94 SHEET 6 AC2 6 ALA J 107 VAL J 109 -1 O ALA J 107 N TYR J 90 SHEET 1 AC3 3 VAL M 19 CYS M 23 0 SHEET 2 AC3 3 THR M 70 ILE M 75 -1 O ILE M 75 N VAL M 19 SHEET 3 AC3 3 PHE M 62 SER M 67 -1 N SER M 63 O THR M 74 SHEET 1 AC4 4 LYS M 45 ILE M 48 0 SHEET 2 AC4 4 VAL M 33 GLN M 38 -1 N TRP M 35 O MET M 47 SHEET 3 AC4 4 ASP M 85 TYR M 91 -1 O ASP M 85 N GLN M 38 SHEET 4 AC4 4 TYR M 96 PHE M 98 -1 O ILE M 97 N ALA M 90 SHEET 1 AC5 3 LEU F 494 THR F 499 0 SHEET 2 AC5 3 TRP F 35 TYR F 40 -1 N TYR F 39 O GLY F 495 SHEET 3 AC5 3 ILE I 603 PRO I 609 -1 O CYS I 604 N VAL F 38 SHEET 1 AC6 5 TRP F 45 ASP F 47 0 SHEET 2 AC6 5 TYR F 486 ILE F 491 -1 O LYS F 490 N LYS F 46 SHEET 3 AC6 5 PHE F 223 LYS F 227 -1 N ALA F 224 O VAL F 489 SHEET 4 AC6 5 SER F 243 VAL F 245 -1 O SER F 243 N LYS F 227 SHEET 5 AC6 5 GLU F 83 HIS F 85 -1 N ILE F 84 O THR F 244 SHEET 1 AC7 2 PHE F 53 ALA F 55 0 SHEET 2 AC7 2 HIS F 216 CYS F 218 -1 O HIS F 216 N ALA F 55 SHEET 1 AC8 2 GLU F 91 ASN F 94 0 SHEET 2 AC8 2 THR F 236 CYS F 239 -1 O GLY F 237 N PHE F 93 SHEET 1 AC9 4 LYS F 121 LEU F 122 0 SHEET 2 AC9 4 ILE F 201 GLN F 203 -1 O ILE F 201 N LEU F 122 SHEET 3 AC9 4 ALA F 433 TYR F 435 1 O TYR F 435 N THR F 202 SHEET 4 AC9 4 ILE F 423 ILE F 424 -1 N ILE F 424 O MET F 434 SHEET 1 AD1 5 LYS F 171 TYR F 177 0 SHEET 2 AD1 5 ILE F 154 ASN F 160 -1 N LYS F 155 O PHE F 176 SHEET 3 AD1 5 LEU F 129 ASN F 133 -1 N GLN F 130 O SER F 158 SHEET 4 AD1 5 GLU F 190 LEU F 193 -1 O TYR F 191 N LEU F 129 SHEET 5 AD1 5 VAL F 181 GLN F 183 -1 N VAL F 182 O ARG F 192 SHEET 1 AD211 LEU F 259 LEU F 261 0 SHEET 2 AD211 ILE F 271 SER F 274 0 SHEET 3 AD211 ILE F 284 ARG F 298 -1 O GLN F 287 N ILE F 271 SHEET 4 AD211 ALA F 329 SER F 334 -1 O ASN F 332 N ASN F 295 SHEET 5 AD211 ILE F 358 PHE F 361 0 SHEET 6 AD211 HIS F 374 CYS F 378 0 SHEET 7 AD211 GLU F 381 CYS F 385 -1 O PHE F 383 N PHE F 376 SHEET 8 AD211 THR F 394 TRP F 395 -1 O TRP F 395 N ILE F 359 SHEET 9 AD211 SER F 413 ILE F 420 -1 O TRP F 419 N TYR F 384 SHEET 10 AD211 ILE F 443 ARG F 456 -1 O LEU F 454 N ILE F 284 SHEET 11 AD211 THR F 465 ARG F 469 -1 O ARG F 469 N THR F 455 SHEET 1 AD3 2 VAL F 304 GLY F 312 0 SHEET 2 AD3 2 GLN F 315 PHE F 320 -1 O PHE F 317 N ILE F 307 SHEET 1 AD4 4 GLN K 3 GLY K 8 0 SHEET 2 AD4 4 GLY K 16 SER K 25 -1 O SER K 25 N GLN K 3 SHEET 3 AD4 4 THR K 77 SER K 82B-1 O LEU K 78 N CYS K 22 SHEET 4 AD4 4 THR K 68 ASP K 72 -1 N ASP K 72 O THR K 77 SHEET 1 AD5 6 MET K 34 GLN K 39 0 SHEET 2 AD5 6 LEU K 45 ILE K 51 -1 O ILE K 51 N MET K 34 SHEET 3 AD5 6 THR K 57 TYR K 59 -1 O PHE K 58 N LEU K 50 SHEET 4 AD5 6 ALA K 88 GLY K 95 -1 O TYR K 91 N VAL K 37 SHEET 5 AD5 6 PHE K 100H TRP K 103 -1 O PHE K 102 N THR K 94 SHEET 6 AD5 6 ALA K 107 VAL K 109 -1 O VAL K 109 N ALA K 88 SHEET 1 AD6 3 VAL N 19 THR N 24 0 SHEET 2 AD6 3 THR N 70 ILE N 75 -1 O ILE N 75 N VAL N 19 SHEET 3 AD6 3 PHE N 62 SER N 67 -1 N SER N 67 O THR N 70 SHEET 1 AD7 5 VAL N 33 GLN N 38 0 SHEET 2 AD7 5 LYS N 45 ILE N 48 -1 O LYS N 45 N GLN N 37 SHEET 3 AD7 5 ASP N 85 TYR N 91 -1 O ASP N 85 N GLN N 38 SHEET 4 AD7 5 TYR N 96 PHE N 98 -1 O ILE N 97 N ALA N 90 SHEET 5 AD7 5 THR N 102 ARG N 103 -1 O THR N 102 N TYR N 86 SHEET 1 AD8 2 UNK L 50 UNK L 51 0 SHEET 2 AD8 2 UNK L 55 UNK L 56 -1 O UNK L 55 N UNK L 51 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.05 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.04 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.04 SSBOND 4 CYS A 131 CYS A 157 1555 1555 2.03 SSBOND 5 CYS A 218 CYS A 247 1555 1555 2.03 SSBOND 6 CYS A 228 CYS A 239 1555 1555 2.04 SSBOND 7 CYS A 296 CYS A 331 1555 1555 2.03 SSBOND 8 CYS A 378 CYS A 445 1555 1555 2.04 SSBOND 9 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 10 CYS A 501 CYS B 605 1555 1555 2.03 SSBOND 11 CYS C 22 CYS C 92 1555 1555 2.04 SSBOND 12 CYS D 23 CYS D 88 1555 1555 2.04 SSBOND 13 CYS B 598 CYS B 604 1555 1555 2.02 SSBOND 14 CYS E 54 CYS E 74 1555 1555 2.04 SSBOND 15 CYS E 119 CYS E 205 1555 1555 2.04 SSBOND 16 CYS E 126 CYS E 196 1555 1555 2.03 SSBOND 17 CYS E 131 CYS E 157 1555 1555 2.03 SSBOND 18 CYS E 218 CYS E 247 1555 1555 2.03 SSBOND 19 CYS E 228 CYS E 239 1555 1555 2.03 SSBOND 20 CYS E 296 CYS E 331 1555 1555 2.04 SSBOND 21 CYS E 378 CYS E 445 1555 1555 2.03 SSBOND 22 CYS E 385 CYS E 418 1555 1555 2.03 SSBOND 23 CYS E 501 CYS G 605 1555 1555 2.03 SSBOND 24 CYS J 22 CYS J 92 1555 1555 2.03 SSBOND 25 CYS M 23 CYS M 88 1555 1555 2.04 SSBOND 26 CYS G 598 CYS G 604 1555 1555 2.02 SSBOND 27 CYS F 54 CYS F 74 1555 1555 2.04 SSBOND 28 CYS F 119 CYS F 205 1555 1555 2.04 SSBOND 29 CYS F 126 CYS F 196 1555 1555 2.03 SSBOND 30 CYS F 131 CYS F 157 1555 1555 2.03 SSBOND 31 CYS F 218 CYS F 247 1555 1555 2.03 SSBOND 32 CYS F 228 CYS F 239 1555 1555 2.03 SSBOND 33 CYS F 296 CYS F 331 1555 1555 2.04 SSBOND 34 CYS F 378 CYS F 445 1555 1555 2.04 SSBOND 35 CYS F 385 CYS F 418 1555 1555 2.03 SSBOND 36 CYS F 501 CYS I 605 1555 1555 2.04 SSBOND 37 CYS K 22 CYS K 92 1555 1555 2.03 SSBOND 38 CYS N 23 CYS N 88 1555 1555 2.04 SSBOND 39 CYS I 598 CYS I 604 1555 1555 2.03 LINK ND2 ASN A 88 C1 NAG A 602 1555 1555 1.44 LINK ND2 ASN A 156 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN A 160 C1 NAG A 603 1555 1555 1.44 LINK ND2 ASN A 197 C1 NAG A 604 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A 605 1555 1555 1.44 LINK ND2 ASN A 262 C1 NAG Q 1 1555 1555 1.45 LINK ND2 ASN A 276 C1 NAG A 606 1555 1555 1.44 LINK ND2 ASN A 295 C1 NAG A 607 1555 1555 1.44 LINK ND2 ASN A 301 C1 NAG A 601 1555 1555 1.44 LINK ND2 ASN A 332 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN A 355 C1 NAG A 610 1555 1555 1.44 LINK ND2 ASN A 386 C1 NAG A 608 1555 1555 1.45 LINK ND2 ASN A 448 C1 NAG A 609 1555 1555 1.44 LINK ND2 ASN B 611 C1 NAG B 701 1555 1555 1.44 LINK ND2 ASN B 618 C1 NAG B 702 1555 1555 1.44 LINK ND2 ASN B 637 C1 NAG B 703 1555 1555 1.44 LINK ND2 ASN E 88 C1 NAG E 602 1555 1555 1.44 LINK ND2 ASN E 156 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN E 160 C1 NAG E 603 1555 1555 1.44 LINK ND2 ASN E 197 C1 NAG E 604 1555 1555 1.44 LINK ND2 ASN E 234 C1 NAG E 605 1555 1555 1.44 LINK ND2 ASN E 262 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN E 276 C1 NAG E 606 1555 1555 1.44 LINK ND2 ASN E 295 C1 NAG E 607 1555 1555 1.44 LINK ND2 ASN E 301 C1 NAG E 601 1555 1555 1.45 LINK ND2 ASN E 332 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN E 339 C1 NAG E 608 1555 1555 1.45 LINK ND2 ASN E 386 C1 NAG E 609 1555 1555 1.44 LINK ND2 ASN E 392 C1 NAG E 611 1555 1555 1.44 LINK ND2 ASN E 448 C1 NAG E 610 1555 1555 1.44 LINK ND2 ASN G 611 C1 NAG G 701 1555 1555 1.44 LINK ND2 ASN G 618 C1 NAG G 702 1555 1555 1.44 LINK ND2 ASN G 637 C1 NAG G 703 1555 1555 1.44 LINK ND2 ASN F 88 C1 NAG F 602 1555 1555 1.44 LINK ND2 ASN F 156 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN F 160 C1 NAG F 603 1555 1555 1.46 LINK ND2 ASN F 197 C1 NAG F 604 1555 1555 1.44 LINK ND2 ASN F 234 C1 NAG F 605 1555 1555 1.44 LINK ND2 ASN F 262 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN F 276 C1 NAG F 606 1555 1555 1.44 LINK ND2 ASN F 295 C1 NAG F 607 1555 1555 1.45 LINK ND2 ASN F 301 C1 NAG F 601 1555 1555 1.44 LINK ND2 ASN F 332 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN F 339 C1 NAG F 608 1555 1555 1.45 LINK ND2 ASN F 355 C1 NAG F 611 1555 1555 1.44 LINK ND2 ASN F 386 C1 NAG F 609 1555 1555 1.45 LINK ND2 ASN F 392 C1 NAG F 612 1555 1555 1.44 LINK ND2 ASN F 448 C1 NAG F 610 1555 1555 1.44 LINK ND2 ASN I 611 C1 NAG I 701 1555 1555 1.44 LINK ND2 ASN I 618 C1 NAG I 702 1555 1555 1.44 LINK ND2 ASN I 637 C1 NAG I 703 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG Q 2 C1 BMA Q 3 1555 1555 1.44 LINK O3 BMA Q 3 C1 MAN Q 4 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.44 LINK O3 BMA T 3 C1 MAN T 4 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000