HEADER VIRAL PROTEIN/IMMUNE SYSTEM 16-FEB-23 8G6U TITLE CRYO-EM STRUCTURE OF T/F100 SOSIP.664 HIV-1 ENV TRIMER WITH LMHS TITLE 2 MUTATIONS IN COMPLEX WITH 8ANC195 AND 10-1074 COMPND MOL_ID: 1; COMPND 2 MOLECULE: CRF01_AE T/F100 HIV-1 GP120; COMPND 3 CHAIN: A, E, I; COMPND 4 ENGINEERED: YES; COMPND 5 MUTATION: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: CRF-1_AE T/F100 HIV-1 GP41; COMPND 8 CHAIN: B, F, J; COMPND 9 SYNONYM: ENV POLYPROTEIN; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: HEAVY CHAIN OF 8ANC195; COMPND 13 CHAIN: C, G, K; COMPND 14 ENGINEERED: YES; COMPND 15 MOL_ID: 4; COMPND 16 MOLECULE: LIGHT CHAIN OF 8ANC195; COMPND 17 CHAIN: D, H, L; COMPND 18 ENGINEERED: YES; COMPND 19 MOL_ID: 5; COMPND 20 MOLECULE: HEAVY CHAIN OF 10-1074; COMPND 21 CHAIN: M, O, Q; COMPND 22 ENGINEERED: YES; COMPND 23 MOL_ID: 6; COMPND 24 MOLECULE: LIGHT CHAIN OF 10-1074; COMPND 25 CHAIN: N, P, R; COMPND 26 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 GENE: ENV; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 10 ORGANISM_TAXID: 11676; SOURCE 11 GENE: ENV; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_COMMON: HUMAN; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 24 ORGANISM_COMMON: HUMAN; SOURCE 25 ORGANISM_TAXID: 9606; SOURCE 26 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 27 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 28 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 29 MOL_ID: 5; SOURCE 30 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 31 ORGANISM_COMMON: HUMAN; SOURCE 32 ORGANISM_TAXID: 9606; SOURCE 33 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 34 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 35 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 36 MOL_ID: 6; SOURCE 37 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 38 ORGANISM_COMMON: HUMAN; SOURCE 39 ORGANISM_TAXID: 9606; SOURCE 40 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 41 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 42 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS T/F100 SOSIP, CLADE A/E HIV-1, 8ANC195, 10-1074, LMHS MUTANT., VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR Y.CHEN,F.ZHOU,R.HUANG,W.TOLBERT,M.PAZGIER REVDAT 1 08-NOV-23 8G6U 0 JRNL AUTH J.PREVOST,Y.CHEN,F.ZHOU,W.D.TOLBERT,R.GASSER,H.MEDJAHED, JRNL AUTH 2 M.NAYRAC,D.N.NGUYEN,S.GOTTUMUKKALA,A.J.HESSELL,V.B.RAO, JRNL AUTH 3 E.POZHARSKI,R.K.HUANG,D.MATTHIES,A.FINZI,M.PAZGIER JRNL TITL STRUCTURE-FUNCTION ANALYSES REVEAL KEY MOLECULAR JRNL TITL 2 DETERMINANTS OF HIV-1 CRF01_AE RESISTANCE TO THE ENTRY JRNL TITL 3 INHIBITOR TEMSAVIR. JRNL REF NAT COMMUN V. 14 6710 2023 JRNL REFN ESSN 2041-1723 JRNL PMID 37872202 JRNL DOI 10.1038/S41467-023-42500-2 REMARK 2 REMARK 2 RESOLUTION. 3.16 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 8DOK REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.160 REMARK 3 NUMBER OF PARTICLES : 549061 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8G6U COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 17-FEB-23. REMARK 100 THE DEPOSITION ID IS D_1000272137. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF T/F100 REMARK 245 SOSIP.664 HIV-1 ENV TRIMER WITH REMARK 245 LMHS MUTATIONS IN COMPLEX WITH REMARK 245 8ANC195 AND 10-1074 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.93 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : LM MUTATIONS REFER TO LAYER REMARK 245 MUTANTS (H61Y/Q105H/V108I/N474D/I475M/K476R) AND HS MUTATION REMARK 245 REFER TO H375S. REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5400.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 105000 REMARK 245 CALIBRATED MAGNIFICATION : 60241 REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, M, N, E, F, G, H, REMARK 350 AND CHAINS: O, P, I, J, K, L, Q, R, S, REMARK 350 AND CHAINS: T, U, V, X, Y, Z, a, b, c, d, REMARK 350 AND CHAINS: f, e, g, h, i, j, k, l, m, REMARK 350 AND CHAINS: n, o, p, q, r, s, t, u, v, w, REMARK 350 AND CHAINS: x, y, z, 0, 1, 2 REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA A 30 REMARK 465 THR A 31 REMARK 465 SER A 132A REMARK 465 ALA A 132B REMARK 465 THR A 132C REMARK 465 VAL A 132D REMARK 465 THR A 132E REMARK 465 ASN A 132F REMARK 465 TYR A 132G REMARK 465 THR A 132H REMARK 465 LYS A 132I REMARK 465 VAL A 132J REMARK 465 ASN A 132K REMARK 465 ASP A 132L REMARK 465 THR A 132M REMARK 465 SER A 132N REMARK 465 ASP A 132O REMARK 465 ILE A 132P REMARK 465 ILE A 132Q REMARK 465 GLY A 132R REMARK 465 ASN A 132S REMARK 465 ILE A 132T REMARK 465 THR A 132U REMARK 465 ASP A 132V REMARK 465 ASP A 184A REMARK 465 ASP A 184B REMARK 465 SER A 184C REMARK 465 SER A 184D REMARK 465 ASN A 184E REMARK 465 ASN A 184F REMARK 465 GLY A 184G REMARK 465 GLY A 458 REMARK 465 GLY A 459 REMARK 465 VAL A 505 REMARK 465 VAL A 506 REMARK 465 GLU A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 ALA B 512 REMARK 465 VAL B 513 REMARK 465 GLY B 514 REMARK 465 LEU B 515 REMARK 465 GLY B 516 REMARK 465 ALA B 517 REMARK 465 MET B 518 REMARK 465 ILE B 519 REMARK 465 PHE B 520 REMARK 465 SER B 546 REMARK 465 GLY B 547 REMARK 465 ILE B 548 REMARK 465 VAL B 549 REMARK 465 GLN B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 SER B 553 REMARK 465 ASN B 554 REMARK 465 LEU B 555 REMARK 465 LEU B 556 REMARK 465 ARG B 557 REMARK 465 ALA B 558 REMARK 465 PRO B 559 REMARK 465 GLU B 560 REMARK 465 ALA B 561 REMARK 465 GLN B 562 REMARK 465 GLN B 563 REMARK 465 HIS B 564 REMARK 465 LEU B 565 REMARK 465 LEU B 566 REMARK 465 GLN B 567 REMARK 465 LEU B 663 REMARK 465 ASP B 664 REMARK 465 ALA B 665 REMARK 465 ALA B 666 REMARK 465 SER C 112 REMARK 465 ALA C 113 REMARK 465 ALA C 114 REMARK 465 SER C 115 REMARK 465 THR C 116 REMARK 465 LYS C 117 REMARK 465 GLY C 118 REMARK 465 PRO C 119 REMARK 465 SER C 120 REMARK 465 VAL C 121 REMARK 465 PHE C 122 REMARK 465 PRO C 123 REMARK 465 LEU C 124 REMARK 465 ALA C 125 REMARK 465 PRO C 126 REMARK 465 SER C 127 REMARK 465 SER C 128 REMARK 465 LYS C 129 REMARK 465 SER C 130 REMARK 465 THR C 131 REMARK 465 SER C 132 REMARK 465 GLY C 133 REMARK 465 GLY C 134 REMARK 465 THR C 135 REMARK 465 ALA C 136 REMARK 465 ALA C 137 REMARK 465 LEU C 138 REMARK 465 GLY C 139 REMARK 465 CYS C 140 REMARK 465 LEU C 141 REMARK 465 VAL C 142 REMARK 465 LYS C 143 REMARK 465 ASP C 144 REMARK 465 TYR C 145 REMARK 465 PHE C 146 REMARK 465 PRO C 147 REMARK 465 GLU C 148 REMARK 465 PRO C 149 REMARK 465 VAL C 150 REMARK 465 THR C 151 REMARK 465 VAL C 152 REMARK 465 SER C 153 REMARK 465 TRP C 154 REMARK 465 ASN C 155 REMARK 465 SER C 156 REMARK 465 GLY C 157 REMARK 465 ALA C 158 REMARK 465 LEU C 159 REMARK 465 THR C 160 REMARK 465 SER C 161 REMARK 465 GLY C 162 REMARK 465 VAL C 163 REMARK 465 HIS C 164 REMARK 465 THR C 165 REMARK 465 PHE C 166 REMARK 465 PRO C 167 REMARK 465 ALA C 168 REMARK 465 VAL C 169 REMARK 465 LEU C 170 REMARK 465 GLN C 171 REMARK 465 SER C 172 REMARK 465 SER C 173 REMARK 465 GLY C 174 REMARK 465 LEU C 175 REMARK 465 TYR C 176 REMARK 465 SER C 177 REMARK 465 LEU C 178 REMARK 465 SER C 179 REMARK 465 SER C 180 REMARK 465 VAL C 181 REMARK 465 VAL C 182 REMARK 465 THR C 183 REMARK 465 VAL C 184 REMARK 465 PRO C 185 REMARK 465 SER C 186 REMARK 465 SER C 187 REMARK 465 SER C 188 REMARK 465 LEU C 189 REMARK 465 GLY C 190 REMARK 465 THR C 191 REMARK 465 GLN C 192 REMARK 465 THR C 193 REMARK 465 TYR C 194 REMARK 465 ILE C 195 REMARK 465 CYS C 196 REMARK 465 ASN C 197 REMARK 465 VAL C 198 REMARK 465 ASN C 199 REMARK 465 HIS C 200 REMARK 465 LYS C 201 REMARK 465 PRO C 202 REMARK 465 SER C 203 REMARK 465 ASN C 204 REMARK 465 THR C 205 REMARK 465 LYS C 206 REMARK 465 VAL C 207 REMARK 465 ASP C 208 REMARK 465 LYS C 209 REMARK 465 ARG C 210 REMARK 465 VAL C 211 REMARK 465 GLU C 212 REMARK 465 PRO C 213 REMARK 465 LYS C 214 REMARK 465 SER C 215 REMARK 465 CYS C 216 REMARK 465 ASP C 217 REMARK 465 LYS C 218 REMARK 465 THR C 219 REMARK 465 LYS D 107 REMARK 465 ARG D 108 REMARK 465 THR D 109 REMARK 465 VAL D 110 REMARK 465 ALA D 111 REMARK 465 ALA D 112 REMARK 465 PRO D 113 REMARK 465 SER D 114 REMARK 465 VAL D 115 REMARK 465 PHE D 116 REMARK 465 ILE D 117 REMARK 465 PHE D 118 REMARK 465 PRO D 119 REMARK 465 PRO D 120 REMARK 465 SER D 121 REMARK 465 ASP D 122 REMARK 465 GLU D 123 REMARK 465 GLN D 124 REMARK 465 LEU D 125 REMARK 465 LYS D 126 REMARK 465 SER D 127 REMARK 465 GLY D 128 REMARK 465 THR D 129 REMARK 465 ALA D 130 REMARK 465 SER D 131 REMARK 465 VAL D 132 REMARK 465 VAL D 133 REMARK 465 CYS D 134 REMARK 465 LEU D 135 REMARK 465 LEU D 136 REMARK 465 ASN D 137 REMARK 465 ASN D 138 REMARK 465 PHE D 139 REMARK 465 TYR D 140 REMARK 465 PRO D 141 REMARK 465 ARG D 142 REMARK 465 GLU D 143 REMARK 465 ALA D 144 REMARK 465 LYS D 145 REMARK 465 VAL D 146 REMARK 465 GLN D 147 REMARK 465 TRP D 148 REMARK 465 LYS D 149 REMARK 465 VAL D 150 REMARK 465 ASP D 151 REMARK 465 ASN D 152 REMARK 465 ALA D 153 REMARK 465 LEU D 154 REMARK 465 GLN D 155 REMARK 465 SER D 156 REMARK 465 GLY D 157 REMARK 465 ASN D 158 REMARK 465 SER D 159 REMARK 465 GLN D 160 REMARK 465 GLU D 161 REMARK 465 SER D 162 REMARK 465 VAL D 163 REMARK 465 THR D 164 REMARK 465 GLU D 165 REMARK 465 GLN D 166 REMARK 465 ASP D 167 REMARK 465 SER D 168 REMARK 465 LYS D 169 REMARK 465 ASP D 170 REMARK 465 SER D 171 REMARK 465 THR D 172 REMARK 465 TYR D 173 REMARK 465 SER D 174 REMARK 465 LEU D 175 REMARK 465 SER D 176 REMARK 465 SER D 177 REMARK 465 THR D 178 REMARK 465 LEU D 179 REMARK 465 THR D 180 REMARK 465 LEU D 181 REMARK 465 SER D 182 REMARK 465 LYS D 183 REMARK 465 ALA D 184 REMARK 465 ASP D 185 REMARK 465 TYR D 186 REMARK 465 GLU D 187 REMARK 465 LYS D 188 REMARK 465 HIS D 189 REMARK 465 LYS D 190 REMARK 465 VAL D 191 REMARK 465 TYR D 192 REMARK 465 ALA D 193 REMARK 465 CYS D 194 REMARK 465 GLU D 195 REMARK 465 VAL D 196 REMARK 465 THR D 197 REMARK 465 HIS D 198 REMARK 465 GLN D 199 REMARK 465 GLY D 200 REMARK 465 LEU D 201 REMARK 465 SER D 202 REMARK 465 SER D 203 REMARK 465 PRO D 204 REMARK 465 VAL D 205 REMARK 465 THR D 206 REMARK 465 LYS D 207 REMARK 465 SER D 208 REMARK 465 PHE D 209 REMARK 465 ASN D 210 REMARK 465 ARG D 211 REMARK 465 GLY D 212 REMARK 465 GLU D 213 REMARK 465 CYS D 214 REMARK 465 SER M 113 REMARK 465 ALA M 114 REMARK 465 SER M 115 REMARK 465 THR M 116 REMARK 465 LYS M 117 REMARK 465 GLY M 118 REMARK 465 PRO M 119 REMARK 465 SER M 120 REMARK 465 VAL M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 LEU M 124 REMARK 465 ALA M 125 REMARK 465 PRO M 126 REMARK 465 SER M 127 REMARK 465 SER M 128 REMARK 465 LYS M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 SER M 132 REMARK 465 GLY M 133 REMARK 465 GLY M 134 REMARK 465 THR M 135 REMARK 465 ALA M 136 REMARK 465 ALA M 137 REMARK 465 LEU M 138 REMARK 465 GLY M 139 REMARK 465 CYS M 140 REMARK 465 LEU M 141 REMARK 465 VAL M 142 REMARK 465 LYS M 143 REMARK 465 ASP M 144 REMARK 465 TYR M 145 REMARK 465 PHE M 146 REMARK 465 PRO M 147 REMARK 465 GLU M 148 REMARK 465 PRO M 149 REMARK 465 VAL M 150 REMARK 465 THR M 151 REMARK 465 VAL M 152 REMARK 465 SER M 153 REMARK 465 TRP M 154 REMARK 465 ASN M 155 REMARK 465 SER M 156 REMARK 465 GLY M 157 REMARK 465 ALA M 158 REMARK 465 LEU M 159 REMARK 465 THR M 160 REMARK 465 SER M 161 REMARK 465 GLY M 162 REMARK 465 VAL M 163 REMARK 465 HIS M 164 REMARK 465 THR M 165 REMARK 465 PHE M 166 REMARK 465 PRO M 167 REMARK 465 ALA M 168 REMARK 465 VAL M 169 REMARK 465 LEU M 170 REMARK 465 GLN M 171 REMARK 465 SER M 172 REMARK 465 SER M 173 REMARK 465 GLY M 174 REMARK 465 LEU M 175 REMARK 465 TYR M 176 REMARK 465 SER M 177 REMARK 465 LEU M 178 REMARK 465 SER M 179 REMARK 465 SER M 180 REMARK 465 VAL M 181 REMARK 465 VAL M 182 REMARK 465 THR M 183 REMARK 465 VAL M 184 REMARK 465 PRO M 185 REMARK 465 SER M 186 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 LEU M 189 REMARK 465 GLY M 190 REMARK 465 THR M 191 REMARK 465 GLN M 192 REMARK 465 THR M 193 REMARK 465 TYR M 194 REMARK 465 ILE M 195 REMARK 465 CYS M 196 REMARK 465 ASN M 197 REMARK 465 VAL M 198 REMARK 465 ASN M 199 REMARK 465 HIS M 200 REMARK 465 LYS M 201 REMARK 465 PRO M 202 REMARK 465 SER M 203 REMARK 465 ASN M 204 REMARK 465 THR M 205 REMARK 465 LYS M 206 REMARK 465 VAL M 207 REMARK 465 ASP M 208 REMARK 465 LYS M 209 REMARK 465 ARG M 210 REMARK 465 VAL M 211 REMARK 465 GLU M 212 REMARK 465 PRO M 213 REMARK 465 LYS M 214 REMARK 465 SER M 215 REMARK 465 CYS M 216 REMARK 465 ASP M 217 REMARK 465 LYS M 218 REMARK 465 THR M 219 REMARK 465 SER N 6 REMARK 465 TYR N 7 REMARK 465 GLN N 109 REMARK 465 PRO N 110 REMARK 465 LYS N 111 REMARK 465 ALA N 112 REMARK 465 ALA N 113 REMARK 465 PRO N 114 REMARK 465 SER N 115 REMARK 465 VAL N 116 REMARK 465 THR N 117 REMARK 465 LEU N 118 REMARK 465 PHE N 119 REMARK 465 PRO N 120 REMARK 465 PRO N 121 REMARK 465 SER N 122 REMARK 465 SER N 123 REMARK 465 GLU N 124 REMARK 465 GLU N 125 REMARK 465 LEU N 126 REMARK 465 GLN N 127 REMARK 465 ALA N 128 REMARK 465 ASN N 129 REMARK 465 LYS N 130 REMARK 465 ALA N 131 REMARK 465 THR N 132 REMARK 465 LEU N 133 REMARK 465 VAL N 134 REMARK 465 CYS N 135 REMARK 465 LEU N 136 REMARK 465 ILE N 137 REMARK 465 SER N 138 REMARK 465 ASP N 139 REMARK 465 PHE N 140 REMARK 465 TYR N 141 REMARK 465 PRO N 142 REMARK 465 GLY N 143 REMARK 465 ALA N 144 REMARK 465 VAL N 145 REMARK 465 THR N 146 REMARK 465 VAL N 147 REMARK 465 ALA N 148 REMARK 465 TRP N 149 REMARK 465 LYS N 150 REMARK 465 ALA N 151 REMARK 465 ASP N 152 REMARK 465 SER N 153 REMARK 465 SER N 154 REMARK 465 PRO N 155 REMARK 465 VAL N 156 REMARK 465 LYS N 157 REMARK 465 ALA N 158 REMARK 465 GLY N 159 REMARK 465 VAL N 160 REMARK 465 GLU N 161 REMARK 465 THR N 162 REMARK 465 THR N 163 REMARK 465 THR N 164 REMARK 465 PRO N 165 REMARK 465 SER N 166 REMARK 465 LYS N 167 REMARK 465 GLN N 168 REMARK 465 SER N 169 REMARK 465 ASN N 170 REMARK 465 ASN N 171 REMARK 465 LYS N 172 REMARK 465 TYR N 173 REMARK 465 ALA N 174 REMARK 465 ALA N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 TYR N 178 REMARK 465 LEU N 179 REMARK 465 SER N 180 REMARK 465 LEU N 181 REMARK 465 THR N 182 REMARK 465 PRO N 183 REMARK 465 GLU N 184 REMARK 465 GLN N 185 REMARK 465 TRP N 186 REMARK 465 LYS N 187 REMARK 465 SER N 188 REMARK 465 HIS N 189 REMARK 465 ARG N 190 REMARK 465 SER N 191 REMARK 465 TYR N 192 REMARK 465 SER N 193 REMARK 465 CYS N 194 REMARK 465 GLN N 195 REMARK 465 VAL N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 GLU N 199 REMARK 465 GLY N 200 REMARK 465 SER N 201 REMARK 465 THR N 202 REMARK 465 VAL N 203 REMARK 465 GLU N 204 REMARK 465 LYS N 205 REMARK 465 THR N 206 REMARK 465 VAL N 207 REMARK 465 ALA N 208 REMARK 465 PRO N 209 REMARK 465 THR N 210 REMARK 465 GLU N 211 REMARK 465 CYS N 212 REMARK 465 SER N 213 REMARK 465 ALA E 30 REMARK 465 THR E 31 REMARK 465 SER E 132A REMARK 465 ALA E 132B REMARK 465 THR E 132C REMARK 465 VAL E 132D REMARK 465 THR E 132E REMARK 465 ASN E 132F REMARK 465 TYR E 132G REMARK 465 THR E 132H REMARK 465 LYS E 132I REMARK 465 VAL E 132J REMARK 465 ASN E 132K REMARK 465 ASP E 132L REMARK 465 THR E 132M REMARK 465 SER E 132N REMARK 465 ASP E 132O REMARK 465 ILE E 132P REMARK 465 ILE E 132Q REMARK 465 GLY E 132R REMARK 465 ASN E 132S REMARK 465 ILE E 132T REMARK 465 THR E 132U REMARK 465 ASP E 132V REMARK 465 ASP E 184A REMARK 465 ASP E 184B REMARK 465 SER E 184C REMARK 465 SER E 184D REMARK 465 ASN E 184E REMARK 465 ASN E 184F REMARK 465 GLY E 184G REMARK 465 GLY E 458 REMARK 465 GLY E 459 REMARK 465 VAL E 505 REMARK 465 VAL E 506 REMARK 465 GLU E 507 REMARK 465 ARG E 508 REMARK 465 ARG E 509 REMARK 465 ARG E 510 REMARK 465 ARG E 511 REMARK 465 ARG E 512 REMARK 465 ARG E 513 REMARK 465 ALA F 512 REMARK 465 VAL F 513 REMARK 465 GLY F 514 REMARK 465 LEU F 515 REMARK 465 GLY F 516 REMARK 465 ALA F 517 REMARK 465 MET F 518 REMARK 465 ILE F 519 REMARK 465 PHE F 520 REMARK 465 SER F 546 REMARK 465 GLY F 547 REMARK 465 ILE F 548 REMARK 465 VAL F 549 REMARK 465 GLN F 550 REMARK 465 GLN F 551 REMARK 465 GLN F 552 REMARK 465 SER F 553 REMARK 465 ASN F 554 REMARK 465 LEU F 555 REMARK 465 LEU F 556 REMARK 465 ARG F 557 REMARK 465 ALA F 558 REMARK 465 PRO F 559 REMARK 465 GLU F 560 REMARK 465 ALA F 561 REMARK 465 GLN F 562 REMARK 465 GLN F 563 REMARK 465 HIS F 564 REMARK 465 LEU F 565 REMARK 465 LEU F 566 REMARK 465 GLN F 567 REMARK 465 LEU F 663 REMARK 465 ASP F 664 REMARK 465 ALA F 665 REMARK 465 ALA F 666 REMARK 465 SER G 112 REMARK 465 ALA G 113 REMARK 465 ALA G 114 REMARK 465 SER G 115 REMARK 465 THR G 116 REMARK 465 LYS G 117 REMARK 465 GLY G 118 REMARK 465 PRO G 119 REMARK 465 SER G 120 REMARK 465 VAL G 121 REMARK 465 PHE G 122 REMARK 465 PRO G 123 REMARK 465 LEU G 124 REMARK 465 ALA G 125 REMARK 465 PRO G 126 REMARK 465 SER G 127 REMARK 465 SER G 128 REMARK 465 LYS G 129 REMARK 465 SER G 130 REMARK 465 THR G 131 REMARK 465 SER G 132 REMARK 465 GLY G 133 REMARK 465 GLY G 134 REMARK 465 THR G 135 REMARK 465 ALA G 136 REMARK 465 ALA G 137 REMARK 465 LEU G 138 REMARK 465 GLY G 139 REMARK 465 CYS G 140 REMARK 465 LEU G 141 REMARK 465 VAL G 142 REMARK 465 LYS G 143 REMARK 465 ASP G 144 REMARK 465 TYR G 145 REMARK 465 PHE G 146 REMARK 465 PRO G 147 REMARK 465 GLU G 148 REMARK 465 PRO G 149 REMARK 465 VAL G 150 REMARK 465 THR G 151 REMARK 465 VAL G 152 REMARK 465 SER G 153 REMARK 465 TRP G 154 REMARK 465 ASN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ALA G 158 REMARK 465 LEU G 159 REMARK 465 THR G 160 REMARK 465 SER G 161 REMARK 465 GLY G 162 REMARK 465 VAL G 163 REMARK 465 HIS G 164 REMARK 465 THR G 165 REMARK 465 PHE G 166 REMARK 465 PRO G 167 REMARK 465 ALA G 168 REMARK 465 VAL G 169 REMARK 465 LEU G 170 REMARK 465 GLN G 171 REMARK 465 SER G 172 REMARK 465 SER G 173 REMARK 465 GLY G 174 REMARK 465 LEU G 175 REMARK 465 TYR G 176 REMARK 465 SER G 177 REMARK 465 LEU G 178 REMARK 465 SER G 179 REMARK 465 SER G 180 REMARK 465 VAL G 181 REMARK 465 VAL G 182 REMARK 465 THR G 183 REMARK 465 VAL G 184 REMARK 465 PRO G 185 REMARK 465 SER G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 LEU G 189 REMARK 465 GLY G 190 REMARK 465 THR G 191 REMARK 465 GLN G 192 REMARK 465 THR G 193 REMARK 465 TYR G 194 REMARK 465 ILE G 195 REMARK 465 CYS G 196 REMARK 465 ASN G 197 REMARK 465 VAL G 198 REMARK 465 ASN G 199 REMARK 465 HIS G 200 REMARK 465 LYS G 201 REMARK 465 PRO G 202 REMARK 465 SER G 203 REMARK 465 ASN G 204 REMARK 465 THR G 205 REMARK 465 LYS G 206 REMARK 465 VAL G 207 REMARK 465 ASP G 208 REMARK 465 LYS G 209 REMARK 465 ARG G 210 REMARK 465 VAL G 211 REMARK 465 GLU G 212 REMARK 465 PRO G 213 REMARK 465 LYS G 214 REMARK 465 SER G 215 REMARK 465 CYS G 216 REMARK 465 ASP G 217 REMARK 465 LYS G 218 REMARK 465 THR G 219 REMARK 465 LYS H 107 REMARK 465 ARG H 108 REMARK 465 THR H 109 REMARK 465 VAL H 110 REMARK 465 ALA H 111 REMARK 465 ALA H 112 REMARK 465 PRO H 113 REMARK 465 SER H 114 REMARK 465 VAL H 115 REMARK 465 PHE H 116 REMARK 465 ILE H 117 REMARK 465 PHE H 118 REMARK 465 PRO H 119 REMARK 465 PRO H 120 REMARK 465 SER H 121 REMARK 465 ASP H 122 REMARK 465 GLU H 123 REMARK 465 GLN H 124 REMARK 465 LEU H 125 REMARK 465 LYS H 126 REMARK 465 SER H 127 REMARK 465 GLY H 128 REMARK 465 THR H 129 REMARK 465 ALA H 130 REMARK 465 SER H 131 REMARK 465 VAL H 132 REMARK 465 VAL H 133 REMARK 465 CYS H 134 REMARK 465 LEU H 135 REMARK 465 LEU H 136 REMARK 465 ASN H 137 REMARK 465 ASN H 138 REMARK 465 PHE H 139 REMARK 465 TYR H 140 REMARK 465 PRO H 141 REMARK 465 ARG H 142 REMARK 465 GLU H 143 REMARK 465 ALA H 144 REMARK 465 LYS H 145 REMARK 465 VAL H 146 REMARK 465 GLN H 147 REMARK 465 TRP H 148 REMARK 465 LYS H 149 REMARK 465 VAL H 150 REMARK 465 ASP H 151 REMARK 465 ASN H 152 REMARK 465 ALA H 153 REMARK 465 LEU H 154 REMARK 465 GLN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ASN H 158 REMARK 465 SER H 159 REMARK 465 GLN H 160 REMARK 465 GLU H 161 REMARK 465 SER H 162 REMARK 465 VAL H 163 REMARK 465 THR H 164 REMARK 465 GLU H 165 REMARK 465 GLN H 166 REMARK 465 ASP H 167 REMARK 465 SER H 168 REMARK 465 LYS H 169 REMARK 465 ASP H 170 REMARK 465 SER H 171 REMARK 465 THR H 172 REMARK 465 TYR H 173 REMARK 465 SER H 174 REMARK 465 LEU H 175 REMARK 465 SER H 176 REMARK 465 SER H 177 REMARK 465 THR H 178 REMARK 465 LEU H 179 REMARK 465 THR H 180 REMARK 465 LEU H 181 REMARK 465 SER H 182 REMARK 465 LYS H 183 REMARK 465 ALA H 184 REMARK 465 ASP H 185 REMARK 465 TYR H 186 REMARK 465 GLU H 187 REMARK 465 LYS H 188 REMARK 465 HIS H 189 REMARK 465 LYS H 190 REMARK 465 VAL H 191 REMARK 465 TYR H 192 REMARK 465 ALA H 193 REMARK 465 CYS H 194 REMARK 465 GLU H 195 REMARK 465 VAL H 196 REMARK 465 THR H 197 REMARK 465 HIS H 198 REMARK 465 GLN H 199 REMARK 465 GLY H 200 REMARK 465 LEU H 201 REMARK 465 SER H 202 REMARK 465 SER H 203 REMARK 465 PRO H 204 REMARK 465 VAL H 205 REMARK 465 THR H 206 REMARK 465 LYS H 207 REMARK 465 SER H 208 REMARK 465 PHE H 209 REMARK 465 ASN H 210 REMARK 465 ARG H 211 REMARK 465 GLY H 212 REMARK 465 GLU H 213 REMARK 465 CYS H 214 REMARK 465 SER O 113 REMARK 465 ALA O 114 REMARK 465 SER O 115 REMARK 465 THR O 116 REMARK 465 LYS O 117 REMARK 465 GLY O 118 REMARK 465 PRO O 119 REMARK 465 SER O 120 REMARK 465 VAL O 121 REMARK 465 PHE O 122 REMARK 465 PRO O 123 REMARK 465 LEU O 124 REMARK 465 ALA O 125 REMARK 465 PRO O 126 REMARK 465 SER O 127 REMARK 465 SER O 128 REMARK 465 LYS O 129 REMARK 465 SER O 130 REMARK 465 THR O 131 REMARK 465 SER O 132 REMARK 465 GLY O 133 REMARK 465 GLY O 134 REMARK 465 THR O 135 REMARK 465 ALA O 136 REMARK 465 ALA O 137 REMARK 465 LEU O 138 REMARK 465 GLY O 139 REMARK 465 CYS O 140 REMARK 465 LEU O 141 REMARK 465 VAL O 142 REMARK 465 LYS O 143 REMARK 465 ASP O 144 REMARK 465 TYR O 145 REMARK 465 PHE O 146 REMARK 465 PRO O 147 REMARK 465 GLU O 148 REMARK 465 PRO O 149 REMARK 465 VAL O 150 REMARK 465 THR O 151 REMARK 465 VAL O 152 REMARK 465 SER O 153 REMARK 465 TRP O 154 REMARK 465 ASN O 155 REMARK 465 SER O 156 REMARK 465 GLY O 157 REMARK 465 ALA O 158 REMARK 465 LEU O 159 REMARK 465 THR O 160 REMARK 465 SER O 161 REMARK 465 GLY O 162 REMARK 465 VAL O 163 REMARK 465 HIS O 164 REMARK 465 THR O 165 REMARK 465 PHE O 166 REMARK 465 PRO O 167 REMARK 465 ALA O 168 REMARK 465 VAL O 169 REMARK 465 LEU O 170 REMARK 465 GLN O 171 REMARK 465 SER O 172 REMARK 465 SER O 173 REMARK 465 GLY O 174 REMARK 465 LEU O 175 REMARK 465 TYR O 176 REMARK 465 SER O 177 REMARK 465 LEU O 178 REMARK 465 SER O 179 REMARK 465 SER O 180 REMARK 465 VAL O 181 REMARK 465 VAL O 182 REMARK 465 THR O 183 REMARK 465 VAL O 184 REMARK 465 PRO O 185 REMARK 465 SER O 186 REMARK 465 SER O 187 REMARK 465 SER O 188 REMARK 465 LEU O 189 REMARK 465 GLY O 190 REMARK 465 THR O 191 REMARK 465 GLN O 192 REMARK 465 THR O 193 REMARK 465 TYR O 194 REMARK 465 ILE O 195 REMARK 465 CYS O 196 REMARK 465 ASN O 197 REMARK 465 VAL O 198 REMARK 465 ASN O 199 REMARK 465 HIS O 200 REMARK 465 LYS O 201 REMARK 465 PRO O 202 REMARK 465 SER O 203 REMARK 465 ASN O 204 REMARK 465 THR O 205 REMARK 465 LYS O 206 REMARK 465 VAL O 207 REMARK 465 ASP O 208 REMARK 465 LYS O 209 REMARK 465 ARG O 210 REMARK 465 VAL O 211 REMARK 465 GLU O 212 REMARK 465 PRO O 213 REMARK 465 LYS O 214 REMARK 465 SER O 215 REMARK 465 CYS O 216 REMARK 465 ASP O 217 REMARK 465 LYS O 218 REMARK 465 THR O 219 REMARK 465 SER P 6 REMARK 465 TYR P 7 REMARK 465 GLN P 109 REMARK 465 PRO P 110 REMARK 465 LYS P 111 REMARK 465 ALA P 112 REMARK 465 ALA P 113 REMARK 465 PRO P 114 REMARK 465 SER P 115 REMARK 465 VAL P 116 REMARK 465 THR P 117 REMARK 465 LEU P 118 REMARK 465 PHE P 119 REMARK 465 PRO P 120 REMARK 465 PRO P 121 REMARK 465 SER P 122 REMARK 465 SER P 123 REMARK 465 GLU P 124 REMARK 465 GLU P 125 REMARK 465 LEU P 126 REMARK 465 GLN P 127 REMARK 465 ALA P 128 REMARK 465 ASN P 129 REMARK 465 LYS P 130 REMARK 465 ALA P 131 REMARK 465 THR P 132 REMARK 465 LEU P 133 REMARK 465 VAL P 134 REMARK 465 CYS P 135 REMARK 465 LEU P 136 REMARK 465 ILE P 137 REMARK 465 SER P 138 REMARK 465 ASP P 139 REMARK 465 PHE P 140 REMARK 465 TYR P 141 REMARK 465 PRO P 142 REMARK 465 GLY P 143 REMARK 465 ALA P 144 REMARK 465 VAL P 145 REMARK 465 THR P 146 REMARK 465 VAL P 147 REMARK 465 ALA P 148 REMARK 465 TRP P 149 REMARK 465 LYS P 150 REMARK 465 ALA P 151 REMARK 465 ASP P 152 REMARK 465 SER P 153 REMARK 465 SER P 154 REMARK 465 PRO P 155 REMARK 465 VAL P 156 REMARK 465 LYS P 157 REMARK 465 ALA P 158 REMARK 465 GLY P 159 REMARK 465 VAL P 160 REMARK 465 GLU P 161 REMARK 465 THR P 162 REMARK 465 THR P 163 REMARK 465 THR P 164 REMARK 465 PRO P 165 REMARK 465 SER P 166 REMARK 465 LYS P 167 REMARK 465 GLN P 168 REMARK 465 SER P 169 REMARK 465 ASN P 170 REMARK 465 ASN P 171 REMARK 465 LYS P 172 REMARK 465 TYR P 173 REMARK 465 ALA P 174 REMARK 465 ALA P 175 REMARK 465 SER P 176 REMARK 465 SER P 177 REMARK 465 TYR P 178 REMARK 465 LEU P 179 REMARK 465 SER P 180 REMARK 465 LEU P 181 REMARK 465 THR P 182 REMARK 465 PRO P 183 REMARK 465 GLU P 184 REMARK 465 GLN P 185 REMARK 465 TRP P 186 REMARK 465 LYS P 187 REMARK 465 SER P 188 REMARK 465 HIS P 189 REMARK 465 ARG P 190 REMARK 465 SER P 191 REMARK 465 TYR P 192 REMARK 465 SER P 193 REMARK 465 CYS P 194 REMARK 465 GLN P 195 REMARK 465 VAL P 196 REMARK 465 THR P 197 REMARK 465 HIS P 198 REMARK 465 GLU P 199 REMARK 465 GLY P 200 REMARK 465 SER P 201 REMARK 465 THR P 202 REMARK 465 VAL P 203 REMARK 465 GLU P 204 REMARK 465 LYS P 205 REMARK 465 THR P 206 REMARK 465 VAL P 207 REMARK 465 ALA P 208 REMARK 465 PRO P 209 REMARK 465 THR P 210 REMARK 465 GLU P 211 REMARK 465 CYS P 212 REMARK 465 SER P 213 REMARK 465 ALA I 30 REMARK 465 THR I 31 REMARK 465 SER I 132A REMARK 465 ALA I 132B REMARK 465 THR I 132C REMARK 465 VAL I 132D REMARK 465 THR I 132E REMARK 465 ASN I 132F REMARK 465 TYR I 132G REMARK 465 THR I 132H REMARK 465 LYS I 132I REMARK 465 VAL I 132J REMARK 465 ASN I 132K REMARK 465 ASP I 132L REMARK 465 THR I 132M REMARK 465 SER I 132N REMARK 465 ASP I 132O REMARK 465 ILE I 132P REMARK 465 ILE I 132Q REMARK 465 GLY I 132R REMARK 465 ASN I 132S REMARK 465 ILE I 132T REMARK 465 THR I 132U REMARK 465 ASP I 132V REMARK 465 ASP I 184A REMARK 465 ASP I 184B REMARK 465 SER I 184C REMARK 465 SER I 184D REMARK 465 ASN I 184E REMARK 465 ASN I 184F REMARK 465 GLY I 184G REMARK 465 GLY I 458 REMARK 465 GLY I 459 REMARK 465 VAL I 505 REMARK 465 VAL I 506 REMARK 465 GLU I 507 REMARK 465 ARG I 508 REMARK 465 ARG I 509 REMARK 465 ARG I 510 REMARK 465 ARG I 511 REMARK 465 ARG I 512 REMARK 465 ARG I 513 REMARK 465 ALA J 512 REMARK 465 VAL J 513 REMARK 465 GLY J 514 REMARK 465 LEU J 515 REMARK 465 GLY J 516 REMARK 465 ALA J 517 REMARK 465 MET J 518 REMARK 465 ILE J 519 REMARK 465 PHE J 520 REMARK 465 SER J 546 REMARK 465 GLY J 547 REMARK 465 ILE J 548 REMARK 465 VAL J 549 REMARK 465 GLN J 550 REMARK 465 GLN J 551 REMARK 465 GLN J 552 REMARK 465 SER J 553 REMARK 465 ASN J 554 REMARK 465 LEU J 555 REMARK 465 LEU J 556 REMARK 465 ARG J 557 REMARK 465 ALA J 558 REMARK 465 PRO J 559 REMARK 465 GLU J 560 REMARK 465 ALA J 561 REMARK 465 GLN J 562 REMARK 465 GLN J 563 REMARK 465 HIS J 564 REMARK 465 LEU J 565 REMARK 465 LEU J 566 REMARK 465 GLN J 567 REMARK 465 LEU J 663 REMARK 465 ASP J 664 REMARK 465 ALA J 665 REMARK 465 ALA J 666 REMARK 465 SER K 112 REMARK 465 ALA K 113 REMARK 465 ALA K 114 REMARK 465 SER K 115 REMARK 465 THR K 116 REMARK 465 LYS K 117 REMARK 465 GLY K 118 REMARK 465 PRO K 119 REMARK 465 SER K 120 REMARK 465 VAL K 121 REMARK 465 PHE K 122 REMARK 465 PRO K 123 REMARK 465 LEU K 124 REMARK 465 ALA K 125 REMARK 465 PRO K 126 REMARK 465 SER K 127 REMARK 465 SER K 128 REMARK 465 LYS K 129 REMARK 465 SER K 130 REMARK 465 THR K 131 REMARK 465 SER K 132 REMARK 465 GLY K 133 REMARK 465 GLY K 134 REMARK 465 THR K 135 REMARK 465 ALA K 136 REMARK 465 ALA K 137 REMARK 465 LEU K 138 REMARK 465 GLY K 139 REMARK 465 CYS K 140 REMARK 465 LEU K 141 REMARK 465 VAL K 142 REMARK 465 LYS K 143 REMARK 465 ASP K 144 REMARK 465 TYR K 145 REMARK 465 PHE K 146 REMARK 465 PRO K 147 REMARK 465 GLU K 148 REMARK 465 PRO K 149 REMARK 465 VAL K 150 REMARK 465 THR K 151 REMARK 465 VAL K 152 REMARK 465 SER K 153 REMARK 465 TRP K 154 REMARK 465 ASN K 155 REMARK 465 SER K 156 REMARK 465 GLY K 157 REMARK 465 ALA K 158 REMARK 465 LEU K 159 REMARK 465 THR K 160 REMARK 465 SER K 161 REMARK 465 GLY K 162 REMARK 465 VAL K 163 REMARK 465 HIS K 164 REMARK 465 THR K 165 REMARK 465 PHE K 166 REMARK 465 PRO K 167 REMARK 465 ALA K 168 REMARK 465 VAL K 169 REMARK 465 LEU K 170 REMARK 465 GLN K 171 REMARK 465 SER K 172 REMARK 465 SER K 173 REMARK 465 GLY K 174 REMARK 465 LEU K 175 REMARK 465 TYR K 176 REMARK 465 SER K 177 REMARK 465 LEU K 178 REMARK 465 SER K 179 REMARK 465 SER K 180 REMARK 465 VAL K 181 REMARK 465 VAL K 182 REMARK 465 THR K 183 REMARK 465 VAL K 184 REMARK 465 PRO K 185 REMARK 465 SER K 186 REMARK 465 SER K 187 REMARK 465 SER K 188 REMARK 465 LEU K 189 REMARK 465 GLY K 190 REMARK 465 THR K 191 REMARK 465 GLN K 192 REMARK 465 THR K 193 REMARK 465 TYR K 194 REMARK 465 ILE K 195 REMARK 465 CYS K 196 REMARK 465 ASN K 197 REMARK 465 VAL K 198 REMARK 465 ASN K 199 REMARK 465 HIS K 200 REMARK 465 LYS K 201 REMARK 465 PRO K 202 REMARK 465 SER K 203 REMARK 465 ASN K 204 REMARK 465 THR K 205 REMARK 465 LYS K 206 REMARK 465 VAL K 207 REMARK 465 ASP K 208 REMARK 465 LYS K 209 REMARK 465 ARG K 210 REMARK 465 VAL K 211 REMARK 465 GLU K 212 REMARK 465 PRO K 213 REMARK 465 LYS K 214 REMARK 465 SER K 215 REMARK 465 CYS K 216 REMARK 465 ASP K 217 REMARK 465 LYS K 218 REMARK 465 THR K 219 REMARK 465 LYS L 107 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 SER Q 113 REMARK 465 ALA Q 114 REMARK 465 SER Q 115 REMARK 465 THR Q 116 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 LYS Q 129 REMARK 465 SER Q 130 REMARK 465 THR Q 131 REMARK 465 SER Q 132 REMARK 465 GLY Q 133 REMARK 465 GLY Q 134 REMARK 465 THR Q 135 REMARK 465 ALA Q 136 REMARK 465 ALA Q 137 REMARK 465 LEU Q 138 REMARK 465 GLY Q 139 REMARK 465 CYS Q 140 REMARK 465 LEU Q 141 REMARK 465 VAL Q 142 REMARK 465 LYS Q 143 REMARK 465 ASP Q 144 REMARK 465 TYR Q 145 REMARK 465 PHE Q 146 REMARK 465 PRO Q 147 REMARK 465 GLU Q 148 REMARK 465 PRO Q 149 REMARK 465 VAL Q 150 REMARK 465 THR Q 151 REMARK 465 VAL Q 152 REMARK 465 SER Q 153 REMARK 465 TRP Q 154 REMARK 465 ASN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ALA Q 158 REMARK 465 LEU Q 159 REMARK 465 THR Q 160 REMARK 465 SER Q 161 REMARK 465 GLY Q 162 REMARK 465 VAL Q 163 REMARK 465 HIS Q 164 REMARK 465 THR Q 165 REMARK 465 PHE Q 166 REMARK 465 PRO Q 167 REMARK 465 ALA Q 168 REMARK 465 VAL Q 169 REMARK 465 LEU Q 170 REMARK 465 GLN Q 171 REMARK 465 SER Q 172 REMARK 465 SER Q 173 REMARK 465 GLY Q 174 REMARK 465 LEU Q 175 REMARK 465 TYR Q 176 REMARK 465 SER Q 177 REMARK 465 LEU Q 178 REMARK 465 SER Q 179 REMARK 465 SER Q 180 REMARK 465 VAL Q 181 REMARK 465 VAL Q 182 REMARK 465 THR Q 183 REMARK 465 VAL Q 184 REMARK 465 PRO Q 185 REMARK 465 SER Q 186 REMARK 465 SER Q 187 REMARK 465 SER Q 188 REMARK 465 LEU Q 189 REMARK 465 GLY Q 190 REMARK 465 THR Q 191 REMARK 465 GLN Q 192 REMARK 465 THR Q 193 REMARK 465 TYR Q 194 REMARK 465 ILE Q 195 REMARK 465 CYS Q 196 REMARK 465 ASN Q 197 REMARK 465 VAL Q 198 REMARK 465 ASN Q 199 REMARK 465 HIS Q 200 REMARK 465 LYS Q 201 REMARK 465 PRO Q 202 REMARK 465 SER Q 203 REMARK 465 ASN Q 204 REMARK 465 THR Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 ASP Q 208 REMARK 465 LYS Q 209 REMARK 465 ARG Q 210 REMARK 465 VAL Q 211 REMARK 465 GLU Q 212 REMARK 465 PRO Q 213 REMARK 465 LYS Q 214 REMARK 465 SER Q 215 REMARK 465 CYS Q 216 REMARK 465 ASP Q 217 REMARK 465 LYS Q 218 REMARK 465 THR Q 219 REMARK 465 SER R 6 REMARK 465 TYR R 7 REMARK 465 GLN R 109 REMARK 465 PRO R 110 REMARK 465 LYS R 111 REMARK 465 ALA R 112 REMARK 465 ALA R 113 REMARK 465 PRO R 114 REMARK 465 SER R 115 REMARK 465 VAL R 116 REMARK 465 THR R 117 REMARK 465 LEU R 118 REMARK 465 PHE R 119 REMARK 465 PRO R 120 REMARK 465 PRO R 121 REMARK 465 SER R 122 REMARK 465 SER R 123 REMARK 465 GLU R 124 REMARK 465 GLU R 125 REMARK 465 LEU R 126 REMARK 465 GLN R 127 REMARK 465 ALA R 128 REMARK 465 ASN R 129 REMARK 465 LYS R 130 REMARK 465 ALA R 131 REMARK 465 THR R 132 REMARK 465 LEU R 133 REMARK 465 VAL R 134 REMARK 465 CYS R 135 REMARK 465 LEU R 136 REMARK 465 ILE R 137 REMARK 465 SER R 138 REMARK 465 ASP R 139 REMARK 465 PHE R 140 REMARK 465 TYR R 141 REMARK 465 PRO R 142 REMARK 465 GLY R 143 REMARK 465 ALA R 144 REMARK 465 VAL R 145 REMARK 465 THR R 146 REMARK 465 VAL R 147 REMARK 465 ALA R 148 REMARK 465 TRP R 149 REMARK 465 LYS R 150 REMARK 465 ALA R 151 REMARK 465 ASP R 152 REMARK 465 SER R 153 REMARK 465 SER R 154 REMARK 465 PRO R 155 REMARK 465 VAL R 156 REMARK 465 LYS R 157 REMARK 465 ALA R 158 REMARK 465 GLY R 159 REMARK 465 VAL R 160 REMARK 465 GLU R 161 REMARK 465 THR R 162 REMARK 465 THR R 163 REMARK 465 THR R 164 REMARK 465 PRO R 165 REMARK 465 SER R 166 REMARK 465 LYS R 167 REMARK 465 GLN R 168 REMARK 465 SER R 169 REMARK 465 ASN R 170 REMARK 465 ASN R 171 REMARK 465 LYS R 172 REMARK 465 TYR R 173 REMARK 465 ALA R 174 REMARK 465 ALA R 175 REMARK 465 SER R 176 REMARK 465 SER R 177 REMARK 465 TYR R 178 REMARK 465 LEU R 179 REMARK 465 SER R 180 REMARK 465 LEU R 181 REMARK 465 THR R 182 REMARK 465 PRO R 183 REMARK 465 GLU R 184 REMARK 465 GLN R 185 REMARK 465 TRP R 186 REMARK 465 LYS R 187 REMARK 465 SER R 188 REMARK 465 HIS R 189 REMARK 465 ARG R 190 REMARK 465 SER R 191 REMARK 465 TYR R 192 REMARK 465 SER R 193 REMARK 465 CYS R 194 REMARK 465 GLN R 195 REMARK 465 VAL R 196 REMARK 465 THR R 197 REMARK 465 HIS R 198 REMARK 465 GLU R 199 REMARK 465 GLY R 200 REMARK 465 SER R 201 REMARK 465 THR R 202 REMARK 465 VAL R 203 REMARK 465 GLU R 204 REMARK 465 LYS R 205 REMARK 465 THR R 206 REMARK 465 VAL R 207 REMARK 465 ALA R 208 REMARK 465 PRO R 209 REMARK 465 THR R 210 REMARK 465 GLU R 211 REMARK 465 CYS R 212 REMARK 465 SER R 213 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OD1 ASP F 644 OE1 GLN J 543 2.13 REMARK 500 OG1 THR E 128 OD2 ASP I 167 2.15 REMARK 500 OG SER M 7 OG1 THR M 21 2.19 REMARK 500 OG SER Q 7 OG1 THR Q 21 2.19 REMARK 500 OG SER O 7 OG1 THR O 21 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PRO M 41 CB - CA - C ANGL. DEV. = 12.9 DEGREES REMARK 500 PRO O 41 CB - CA - C ANGL. DEV. = 13.0 DEGREES REMARK 500 PRO Q 41 CB - CA - C ANGL. DEV. = 12.9 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LYS A 59 -158.14 -95.78 REMARK 500 ALA A 60 -30.55 110.14 REMARK 500 GLU A 62 32.62 -92.15 REMARK 500 THR A 63 -123.18 67.53 REMARK 500 VAL A 65 73.51 46.85 REMARK 500 ALA A 73 -5.72 69.08 REMARK 500 PRO A 118 48.30 -87.53 REMARK 500 CYS A 119 -167.10 -162.80 REMARK 500 VAL A 154 161.35 52.46 REMARK 500 THR A 198 -60.42 -95.01 REMARK 500 ALA A 204 -108.16 -53.93 REMARK 500 LYS A 207 69.10 -106.65 REMARK 500 GLN A 258 -8.27 72.89 REMARK 500 LEU A 259 119.00 -161.51 REMARK 500 LEU A 261 -164.66 -127.66 REMARK 500 ASN A 262 128.10 -36.17 REMARK 500 LEU A 277 -37.93 -36.37 REMARK 500 ASN A 301 121.29 -35.41 REMARK 500 PRO A 313 82.43 -68.09 REMARK 500 TYR A 384 66.61 60.82 REMARK 500 LYS A 405 -8.56 73.03 REMARK 500 THR A 408 -97.70 179.28 REMARK 500 ARG A 409 -68.11 67.79 REMARK 500 ASP A 410 -167.67 62.27 REMARK 500 ASN A 411 25.75 -143.50 REMARK 500 GLN A 428 -133.84 54.60 REMARK 500 LYS A 502 -6.15 72.79 REMARK 500 LEU B 537 4.20 -61.09 REMARK 500 ALA B 541 -97.19 69.57 REMARK 500 LEU B 544 -170.65 34.59 REMARK 500 SER B 599 -126.03 58.06 REMARK 500 ASN B 611 137.83 -37.48 REMARK 500 PHE B 619 -68.57 19.22 REMARK 500 ASN B 624 -50.61 -121.72 REMARK 500 ASN B 625 47.64 -80.31 REMARK 500 ARG C 54 55.73 38.66 REMARK 500 SER M 28 -167.64 -79.67 REMARK 500 MET M 29 -60.38 -92.87 REMARK 500 PRO M 41 23.28 41.28 REMARK 500 LEU M 63 -73.38 -111.07 REMARK 500 ASN M 64 2.22 -152.53 REMARK 500 ARG M 71 -36.66 -131.02 REMARK 500 ASN M 76 98.53 -162.31 REMARK 500 SER N 12 -123.39 104.99 REMARK 500 ASN N 51 -11.91 72.21 REMARK 500 SER N 56 133.69 -171.26 REMARK 500 ASP N 66A 53.52 -94.79 REMARK 500 LYS E 59 -158.12 -95.78 REMARK 500 ALA E 60 -30.56 110.13 REMARK 500 GLU E 62 32.56 -92.10 REMARK 500 REMARK 500 THIS ENTRY HAS 141 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-29783 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF T/F100 SOSIP.664 HIV-1 ENV TRIMER WITH LMHS REMARK 900 MUTATIONS IN COMPLEX WITH 8ANC195 AND 10-1074 DBREF1 8G6U A 30 507 UNP A0A6C0ZY47_9HIV1 DBREF2 8G6U A A0A6C0ZY47 29 508 DBREF1 8G6U B 512 664 UNP A0A6C0ZY47_9HIV1 DBREF2 8G6U B A0A6C0ZY47 513 665 DBREF 8G6U C 1 219 PDB 8G6U 8G6U 1 219 DBREF 8G6U D 1 214 PDB 8G6U 8G6U 1 214 DBREF 8G6U M 1 219 PDB 8G6U 8G6U 1 219 DBREF 8G6U N 6 213 PDB 8G6U 8G6U 6 213 DBREF1 8G6U E 30 507 UNP A0A6C0ZY47_9HIV1 DBREF2 8G6U E A0A6C0ZY47 29 508 DBREF1 8G6U F 512 664 UNP A0A6C0ZY47_9HIV1 DBREF2 8G6U F A0A6C0ZY47 513 665 DBREF 8G6U G 1 219 PDB 8G6U 8G6U 1 219 DBREF 8G6U H 1 214 PDB 8G6U 8G6U 1 214 DBREF 8G6U O 1 219 PDB 8G6U 8G6U 1 219 DBREF 8G6U P 6 213 PDB 8G6U 8G6U 6 213 DBREF1 8G6U I 30 507 UNP A0A6C0ZY47_9HIV1 DBREF2 8G6U I A0A6C0ZY47 29 508 DBREF1 8G6U J 512 664 UNP A0A6C0ZY47_9HIV1 DBREF2 8G6U J A0A6C0ZY47 513 665 DBREF 8G6U K 1 219 PDB 8G6U 8G6U 1 219 DBREF 8G6U L 1 214 PDB 8G6U 8G6U 1 214 DBREF 8G6U Q 1 219 PDB 8G6U 8G6U 1 219 DBREF 8G6U R 6 213 PDB 8G6U 8G6U 6 213 SEQADV 8G6U TYR A 61 UNP A0A6C0ZY4 HIS 60 ENGINEERED MUTATION SEQADV 8G6U HIS A 105 UNP A0A6C0ZY4 GLN 104 ENGINEERED MUTATION SEQADV 8G6U ILE A 108 UNP A0A6C0ZY4 VAL 107 ENGINEERED MUTATION SEQADV 8G6U SER A 375 UNP A0A6C0ZY4 HIS 381 CONFLICT SEQADV 8G6U A UNP A0A6C0ZY4 SER 462 DELETION SEQADV 8G6U ASP A 474 UNP A0A6C0ZY4 ASN 475 ENGINEERED MUTATION SEQADV 8G6U MET A 475 UNP A0A6C0ZY4 ILE 476 ENGINEERED MUTATION SEQADV 8G6U ARG A 476 UNP A0A6C0ZY4 LYS 477 ENGINEERED MUTATION SEQADV 8G6U CYS A 501 UNP A0A6C0ZY4 ALA 502 CONFLICT SEQADV 8G6U ARG A 508 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG A 509 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG A 510 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG A 511 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG A 512 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG A 513 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U PRO B 559 UNP A0A6C0ZY4 ILE 560 CONFLICT SEQADV 8G6U CYS B 605 UNP A0A6C0ZY4 THR 606 CONFLICT SEQADV 8G6U ALA B 665 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ALA B 666 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U TYR E 61 UNP A0A6C0ZY4 HIS 60 ENGINEERED MUTATION SEQADV 8G6U HIS E 105 UNP A0A6C0ZY4 GLN 104 ENGINEERED MUTATION SEQADV 8G6U ILE E 108 UNP A0A6C0ZY4 VAL 107 ENGINEERED MUTATION SEQADV 8G6U SER E 375 UNP A0A6C0ZY4 HIS 381 CONFLICT SEQADV 8G6U E UNP A0A6C0ZY4 SER 462 DELETION SEQADV 8G6U ASP E 474 UNP A0A6C0ZY4 ASN 475 ENGINEERED MUTATION SEQADV 8G6U MET E 475 UNP A0A6C0ZY4 ILE 476 ENGINEERED MUTATION SEQADV 8G6U ARG E 476 UNP A0A6C0ZY4 LYS 477 ENGINEERED MUTATION SEQADV 8G6U CYS E 501 UNP A0A6C0ZY4 ALA 502 CONFLICT SEQADV 8G6U ARG E 508 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG E 509 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG E 510 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG E 511 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG E 512 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG E 513 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U PRO F 559 UNP A0A6C0ZY4 ILE 560 CONFLICT SEQADV 8G6U CYS F 605 UNP A0A6C0ZY4 THR 606 CONFLICT SEQADV 8G6U ALA F 665 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ALA F 666 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U TYR I 61 UNP A0A6C0ZY4 HIS 60 ENGINEERED MUTATION SEQADV 8G6U HIS I 105 UNP A0A6C0ZY4 GLN 104 ENGINEERED MUTATION SEQADV 8G6U ILE I 108 UNP A0A6C0ZY4 VAL 107 ENGINEERED MUTATION SEQADV 8G6U SER I 375 UNP A0A6C0ZY4 HIS 381 CONFLICT SEQADV 8G6U I UNP A0A6C0ZY4 SER 462 DELETION SEQADV 8G6U ASP I 474 UNP A0A6C0ZY4 ASN 475 ENGINEERED MUTATION SEQADV 8G6U MET I 475 UNP A0A6C0ZY4 ILE 476 ENGINEERED MUTATION SEQADV 8G6U ARG I 476 UNP A0A6C0ZY4 LYS 477 ENGINEERED MUTATION SEQADV 8G6U CYS I 501 UNP A0A6C0ZY4 ALA 502 CONFLICT SEQADV 8G6U ARG I 508 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG I 509 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG I 510 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG I 511 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG I 512 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ARG I 513 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U PRO J 559 UNP A0A6C0ZY4 ILE 560 CONFLICT SEQADV 8G6U CYS J 605 UNP A0A6C0ZY4 THR 606 CONFLICT SEQADV 8G6U ALA J 665 UNP A0A6C0ZY4 EXPRESSION TAG SEQADV 8G6U ALA J 666 UNP A0A6C0ZY4 EXPRESSION TAG SEQRES 1 A 485 ALA THR ASN ASN LEU TRP VAL THR VAL TYR TYR GLY VAL SEQRES 2 A 485 PRO VAL TRP ARG ASP ALA ASP THR THR LEU PHE CYS ALA SEQRES 3 A 485 SER ASP ALA LYS ALA TYR GLU THR GLU VAL HIS ASN VAL SEQRES 4 A 485 TRP ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO SEQRES 5 A 485 GLN GLU MET HIS LEU LYS ASN VAL THR GLU ASN PHE ASN SEQRES 6 A 485 MET TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP SEQRES 7 A 485 ILE ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL SEQRES 8 A 485 LYS LEU THR PRO LEU CYS VAL THR LEU ASN CYS THR SER SEQRES 9 A 485 ALA THR VAL THR ASN TYR THR LYS VAL ASN ASP THR SER SEQRES 10 A 485 ASP ILE ILE GLY ASN ILE THR ASP ASP VAL ARG ASN CYS SEQRES 11 A 485 SER PHE ASN MET THR THR GLU LEU ARG ASP LYS GLN GLN SEQRES 12 A 485 LYS VAL TYR ALA LEU PHE TYR LYS LEU ASP ILE VAL PRO SEQRES 13 A 485 ILE ASP ASP SER SER ASN ASN GLY SER SER ASN PHE SER SEQRES 14 A 485 GLU TYR ARG LEU ILE ASN CYS ASN THR SER VAL ILE LYS SEQRES 15 A 485 GLN ALA CYS PRO LYS VAL SER PHE ASP PRO ILE PRO ILE SEQRES 16 A 485 HIS TYR CYS THR PRO ALA GLY TYR ALA ILE LEU ARG CYS SEQRES 17 A 485 ASN ASP LYS LYS PHE ASN GLY THR GLY PRO CYS LYS ASN SEQRES 18 A 485 VAL SER SER VAL GLN CYS THR HIS GLY ILE LYS PRO VAL SEQRES 19 A 485 VAL SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA GLU SEQRES 20 A 485 GLU GLY ILE ILE ILE ARG SER GLU ASN LEU THR ASN ASN SEQRES 21 A 485 ALA LYS THR ILE ILE VAL HIS PHE ASN GLU SER VAL LYS SEQRES 22 A 485 ILE ASN CYS THR ARG PRO SER ASN ASN THR ARG THR GLY SEQRES 23 A 485 ILE HIS ILE GLY PRO GLY GLN VAL PHE TYR LYS THR GLY SEQRES 24 A 485 ASP ILE ILE GLY ASP ILE ARG LYS ALA TYR CYS ASN ILE SEQRES 25 A 485 SER GLY ALA GLN TRP HIS LYS VAL LEU GLY ARG VAL ALA SEQRES 26 A 485 ASN LYS LEU LYS GLU HIS PHE ASN ASN LYS THR ILE VAL SEQRES 27 A 485 PHE LYS PRO SER SER GLY GLY ASP PRO GLU ILE THR MET SEQRES 28 A 485 HIS SER PHE ASN CYS ARG GLY GLU PHE PHE TYR CYS ASN SEQRES 29 A 485 THR THR LYS LEU PHE ASN SER THR TRP GLY GLY ASN LYS SEQRES 30 A 485 ASN GLU THR ARG ASP ASN GLY THR ILE THR ILE PRO CYS SEQRES 31 A 485 ARG ILE LYS GLN ILE ILE ASN MET TRP GLN GLY VAL GLY SEQRES 32 A 485 GLN ALA MET TYR ALA PRO PRO ILE LYS GLY VAL ILE LYS SEQRES 33 A 485 CYS LEU SER ASN ILE THR GLY ILE LEU LEU THR ARG ASP SEQRES 34 A 485 GLY GLY ASN ASP THR GLU ASN ASN GLU THR PHE ARG PRO SEQRES 35 A 485 GLY GLY GLY ASP MET ARG ASP ASN TRP ARG ASN GLU LEU SEQRES 36 A 485 TYR LYS TYR LYS VAL VAL GLN ILE GLU PRO LEU GLY ILE SEQRES 37 A 485 ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLU ARG ARG SEQRES 38 A 485 ARG ARG ARG ARG SEQRES 1 B 155 ALA VAL GLY LEU GLY ALA MET ILE PHE GLY PHE LEU GLY SEQRES 2 B 155 ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR LEU SEQRES 3 B 155 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 155 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 B 155 HIS LEU LEU GLN LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 B 155 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU GLN ASP SEQRES 7 B 155 GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS ILE SEQRES 8 B 155 ILE CYS CYS THR ALA VAL PRO TRP ASN SER SER TRP SER SEQRES 9 B 155 ASN LYS THR PHE GLU GLU ILE TRP ASN ASN MET THR TRP SEQRES 10 B 155 ILE GLU TRP GLU ARG GLU ILE SER ASN TYR THR SER GLN SEQRES 11 B 155 ILE TYR ASP ILE LEU THR ILE SER GLN THR GLN GLN GLU SEQRES 12 B 155 LYS ASN GLU LYS ASP LEU LEU GLU LEU ASP ALA ALA SEQRES 1 C 238 GLN ILE HIS LEU VAL GLN SER GLY THR GLU VAL LYS LYS SEQRES 2 C 238 PRO GLY SER SER VAL THR VAL SER CYS LYS ALA TYR GLY SEQRES 3 C 238 VAL ASN THR PHE GLY LEU TYR ALA VAL ASN TRP VAL ARG SEQRES 4 C 238 GLN ALA PRO GLY GLN SER LEU GLU TYR ILE GLY GLN ILE SEQRES 5 C 238 TRP ARG TRP LYS SER SER ALA SER HIS HIS PHE ARG GLY SEQRES 6 C 238 ARG VAL LEU ILE SER ALA VAL ASP LEU THR GLY SER SER SEQRES 7 C 238 PRO PRO ILE SER SER LEU GLU ILE LYS ASN LEU THR SER SEQRES 8 C 238 ASP ASP THR ALA VAL TYR PHE CYS THR THR THR SER THR SEQRES 9 C 238 TYR ASP ARG TRP SER GLY LEU HIS HIS ASP GLY VAL MET SEQRES 10 C 238 ALA PHE SER SER TRP GLY GLN GLY THR LEU ILE SER VAL SEQRES 11 C 238 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 C 238 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 C 238 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 C 238 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 C 238 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 C 238 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 C 238 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 C 238 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 C 238 CYS ASP LYS THR SEQRES 1 D 215 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 D 215 SER THR GLY ASP THR VAL ARG ILE SER CYS ARG ALA SER SEQRES 3 D 215 GLN SER ILE THR GLY ASN TRP VAL ALA TRP TYR GLN GLN SEQRES 4 D 215 ARG PRO GLY LYS ALA PRO ARG LEU LEU ILE TYR ARG GLY SEQRES 5 D 215 ALA ALA LEU LEU GLY GLY VAL PRO SER ARG PHE ARG GLY SEQRES 6 D 215 SER ALA ALA GLY THR ASP PHE THR LEU THR ILE GLY ASN SEQRES 7 D 215 LEU GLN ALA GLU ASP PHE GLY THR PHE TYR CYS GLN GLN SEQRES 8 D 215 TYR ASP THR TYR PRO GLY THR PHE GLY GLN GLY THR LYS SEQRES 9 D 215 VAL GLU VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 D 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 D 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 D 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 D 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 D 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 D 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 D 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 D 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 M 238 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 M 238 PRO SER GLU THR LEU SER VAL THR CYS SER VAL SER GLY SEQRES 3 M 238 ASP SER MET ASN ASN TYR TYR TRP THR TRP ILE ARG GLN SEQRES 4 M 238 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR ILE SER SEQRES 5 M 238 ASP ARG GLU SER ALA THR TYR ASN PRO SER LEU ASN SER SEQRES 6 M 238 ARG VAL VAL ILE SER ARG ASP THR SER LYS ASN GLN LEU SEQRES 7 M 238 SER LEU LYS LEU ASN SER VAL THR PRO ALA ASP THR ALA SEQRES 8 M 238 VAL TYR TYR CYS ALA THR ALA ARG ARG GLY GLN ARG ILE SEQRES 9 M 238 TYR GLY VAL VAL SER PHE GLY GLU PHE PHE TYR TYR TYR SEQRES 10 M 238 SER MET ASP VAL TRP GLY LYS GLY THR THR VAL THR VAL SEQRES 11 M 238 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 M 238 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 M 238 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 M 238 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 M 238 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 M 238 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 M 238 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 M 238 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 M 238 CYS ASP LYS THR SEQRES 1 N 214 SER TYR VAL ARG PRO LEU SER VAL ALA LEU GLY GLU THR SEQRES 2 N 214 ALA ARG ILE SER CYS GLY ARG GLN ALA LEU GLY SER ARG SEQRES 3 N 214 ALA VAL GLN TRP TYR GLN HIS ARG PRO GLY GLN ALA PRO SEQRES 4 N 214 ILE LEU LEU ILE TYR ASN ASN GLN ASP ARG PRO SER GLY SEQRES 5 N 214 ILE PRO GLU ARG PHE SER GLY THR PRO ASP ILE ASN PHE SEQRES 6 N 214 GLY THR ARG ALA THR LEU THR ILE SER GLY VAL GLU ALA SEQRES 7 N 214 GLY ASP GLU ALA ASP TYR TYR CYS HIS MET TRP ASP SER SEQRES 8 N 214 ARG SER GLY PHE SER TRP SER PHE GLY GLY ALA THR ARG SEQRES 9 N 214 LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 N 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 N 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 N 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 N 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 N 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 N 214 THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER CYS SEQRES 16 N 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 N 214 ALA PRO THR GLU CYS SER SEQRES 1 E 485 ALA THR ASN ASN LEU TRP VAL THR VAL TYR TYR GLY VAL SEQRES 2 E 485 PRO VAL TRP ARG ASP ALA ASP THR THR LEU PHE CYS ALA SEQRES 3 E 485 SER ASP ALA LYS ALA TYR GLU THR GLU VAL HIS ASN VAL SEQRES 4 E 485 TRP ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO SEQRES 5 E 485 GLN GLU MET HIS LEU LYS ASN VAL THR GLU ASN PHE ASN SEQRES 6 E 485 MET TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP SEQRES 7 E 485 ILE ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL SEQRES 8 E 485 LYS LEU THR PRO LEU CYS VAL THR LEU ASN CYS THR SER SEQRES 9 E 485 ALA THR VAL THR ASN TYR THR LYS VAL ASN ASP THR SER SEQRES 10 E 485 ASP ILE ILE GLY ASN ILE THR ASP ASP VAL ARG ASN CYS SEQRES 11 E 485 SER PHE ASN MET THR THR GLU LEU ARG ASP LYS GLN GLN SEQRES 12 E 485 LYS VAL TYR ALA LEU PHE TYR LYS LEU ASP ILE VAL PRO SEQRES 13 E 485 ILE ASP ASP SER SER ASN ASN GLY SER SER ASN PHE SER SEQRES 14 E 485 GLU TYR ARG LEU ILE ASN CYS ASN THR SER VAL ILE LYS SEQRES 15 E 485 GLN ALA CYS PRO LYS VAL SER PHE ASP PRO ILE PRO ILE SEQRES 16 E 485 HIS TYR CYS THR PRO ALA GLY TYR ALA ILE LEU ARG CYS SEQRES 17 E 485 ASN ASP LYS LYS PHE ASN GLY THR GLY PRO CYS LYS ASN SEQRES 18 E 485 VAL SER SER VAL GLN CYS THR HIS GLY ILE LYS PRO VAL SEQRES 19 E 485 VAL SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA GLU SEQRES 20 E 485 GLU GLY ILE ILE ILE ARG SER GLU ASN LEU THR ASN ASN SEQRES 21 E 485 ALA LYS THR ILE ILE VAL HIS PHE ASN GLU SER VAL LYS SEQRES 22 E 485 ILE ASN CYS THR ARG PRO SER ASN ASN THR ARG THR GLY SEQRES 23 E 485 ILE HIS ILE GLY PRO GLY GLN VAL PHE TYR LYS THR GLY SEQRES 24 E 485 ASP ILE ILE GLY ASP ILE ARG LYS ALA TYR CYS ASN ILE SEQRES 25 E 485 SER GLY ALA GLN TRP HIS LYS VAL LEU GLY ARG VAL ALA SEQRES 26 E 485 ASN LYS LEU LYS GLU HIS PHE ASN ASN LYS THR ILE VAL SEQRES 27 E 485 PHE LYS PRO SER SER GLY GLY ASP PRO GLU ILE THR MET SEQRES 28 E 485 HIS SER PHE ASN CYS ARG GLY GLU PHE PHE TYR CYS ASN SEQRES 29 E 485 THR THR LYS LEU PHE ASN SER THR TRP GLY GLY ASN LYS SEQRES 30 E 485 ASN GLU THR ARG ASP ASN GLY THR ILE THR ILE PRO CYS SEQRES 31 E 485 ARG ILE LYS GLN ILE ILE ASN MET TRP GLN GLY VAL GLY SEQRES 32 E 485 GLN ALA MET TYR ALA PRO PRO ILE LYS GLY VAL ILE LYS SEQRES 33 E 485 CYS LEU SER ASN ILE THR GLY ILE LEU LEU THR ARG ASP SEQRES 34 E 485 GLY GLY ASN ASP THR GLU ASN ASN GLU THR PHE ARG PRO SEQRES 35 E 485 GLY GLY GLY ASP MET ARG ASP ASN TRP ARG ASN GLU LEU SEQRES 36 E 485 TYR LYS TYR LYS VAL VAL GLN ILE GLU PRO LEU GLY ILE SEQRES 37 E 485 ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLU ARG ARG SEQRES 38 E 485 ARG ARG ARG ARG SEQRES 1 F 155 ALA VAL GLY LEU GLY ALA MET ILE PHE GLY PHE LEU GLY SEQRES 2 F 155 ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR LEU SEQRES 3 F 155 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 F 155 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 F 155 HIS LEU LEU GLN LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 F 155 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU GLN ASP SEQRES 7 F 155 GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS ILE SEQRES 8 F 155 ILE CYS CYS THR ALA VAL PRO TRP ASN SER SER TRP SER SEQRES 9 F 155 ASN LYS THR PHE GLU GLU ILE TRP ASN ASN MET THR TRP SEQRES 10 F 155 ILE GLU TRP GLU ARG GLU ILE SER ASN TYR THR SER GLN SEQRES 11 F 155 ILE TYR ASP ILE LEU THR ILE SER GLN THR GLN GLN GLU SEQRES 12 F 155 LYS ASN GLU LYS ASP LEU LEU GLU LEU ASP ALA ALA SEQRES 1 G 238 GLN ILE HIS LEU VAL GLN SER GLY THR GLU VAL LYS LYS SEQRES 2 G 238 PRO GLY SER SER VAL THR VAL SER CYS LYS ALA TYR GLY SEQRES 3 G 238 VAL ASN THR PHE GLY LEU TYR ALA VAL ASN TRP VAL ARG SEQRES 4 G 238 GLN ALA PRO GLY GLN SER LEU GLU TYR ILE GLY GLN ILE SEQRES 5 G 238 TRP ARG TRP LYS SER SER ALA SER HIS HIS PHE ARG GLY SEQRES 6 G 238 ARG VAL LEU ILE SER ALA VAL ASP LEU THR GLY SER SER SEQRES 7 G 238 PRO PRO ILE SER SER LEU GLU ILE LYS ASN LEU THR SER SEQRES 8 G 238 ASP ASP THR ALA VAL TYR PHE CYS THR THR THR SER THR SEQRES 9 G 238 TYR ASP ARG TRP SER GLY LEU HIS HIS ASP GLY VAL MET SEQRES 10 G 238 ALA PHE SER SER TRP GLY GLN GLY THR LEU ILE SER VAL SEQRES 11 G 238 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 G 238 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 G 238 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 G 238 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 G 238 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 G 238 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 G 238 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 G 238 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 G 238 CYS ASP LYS THR SEQRES 1 H 215 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 H 215 SER THR GLY ASP THR VAL ARG ILE SER CYS ARG ALA SER SEQRES 3 H 215 GLN SER ILE THR GLY ASN TRP VAL ALA TRP TYR GLN GLN SEQRES 4 H 215 ARG PRO GLY LYS ALA PRO ARG LEU LEU ILE TYR ARG GLY SEQRES 5 H 215 ALA ALA LEU LEU GLY GLY VAL PRO SER ARG PHE ARG GLY SEQRES 6 H 215 SER ALA ALA GLY THR ASP PHE THR LEU THR ILE GLY ASN SEQRES 7 H 215 LEU GLN ALA GLU ASP PHE GLY THR PHE TYR CYS GLN GLN SEQRES 8 H 215 TYR ASP THR TYR PRO GLY THR PHE GLY GLN GLY THR LYS SEQRES 9 H 215 VAL GLU VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 H 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 H 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 H 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 H 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 H 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 H 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 H 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 H 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 O 238 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 O 238 PRO SER GLU THR LEU SER VAL THR CYS SER VAL SER GLY SEQRES 3 O 238 ASP SER MET ASN ASN TYR TYR TRP THR TRP ILE ARG GLN SEQRES 4 O 238 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR ILE SER SEQRES 5 O 238 ASP ARG GLU SER ALA THR TYR ASN PRO SER LEU ASN SER SEQRES 6 O 238 ARG VAL VAL ILE SER ARG ASP THR SER LYS ASN GLN LEU SEQRES 7 O 238 SER LEU LYS LEU ASN SER VAL THR PRO ALA ASP THR ALA SEQRES 8 O 238 VAL TYR TYR CYS ALA THR ALA ARG ARG GLY GLN ARG ILE SEQRES 9 O 238 TYR GLY VAL VAL SER PHE GLY GLU PHE PHE TYR TYR TYR SEQRES 10 O 238 SER MET ASP VAL TRP GLY LYS GLY THR THR VAL THR VAL SEQRES 11 O 238 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 O 238 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 O 238 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 O 238 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 O 238 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 O 238 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 O 238 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 O 238 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 O 238 CYS ASP LYS THR SEQRES 1 P 214 SER TYR VAL ARG PRO LEU SER VAL ALA LEU GLY GLU THR SEQRES 2 P 214 ALA ARG ILE SER CYS GLY ARG GLN ALA LEU GLY SER ARG SEQRES 3 P 214 ALA VAL GLN TRP TYR GLN HIS ARG PRO GLY GLN ALA PRO SEQRES 4 P 214 ILE LEU LEU ILE TYR ASN ASN GLN ASP ARG PRO SER GLY SEQRES 5 P 214 ILE PRO GLU ARG PHE SER GLY THR PRO ASP ILE ASN PHE SEQRES 6 P 214 GLY THR ARG ALA THR LEU THR ILE SER GLY VAL GLU ALA SEQRES 7 P 214 GLY ASP GLU ALA ASP TYR TYR CYS HIS MET TRP ASP SER SEQRES 8 P 214 ARG SER GLY PHE SER TRP SER PHE GLY GLY ALA THR ARG SEQRES 9 P 214 LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 P 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 P 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 P 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 P 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 P 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 P 214 THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER CYS SEQRES 16 P 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 P 214 ALA PRO THR GLU CYS SER SEQRES 1 I 485 ALA THR ASN ASN LEU TRP VAL THR VAL TYR TYR GLY VAL SEQRES 2 I 485 PRO VAL TRP ARG ASP ALA ASP THR THR LEU PHE CYS ALA SEQRES 3 I 485 SER ASP ALA LYS ALA TYR GLU THR GLU VAL HIS ASN VAL SEQRES 4 I 485 TRP ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO SEQRES 5 I 485 GLN GLU MET HIS LEU LYS ASN VAL THR GLU ASN PHE ASN SEQRES 6 I 485 MET TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP SEQRES 7 I 485 ILE ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL SEQRES 8 I 485 LYS LEU THR PRO LEU CYS VAL THR LEU ASN CYS THR SER SEQRES 9 I 485 ALA THR VAL THR ASN TYR THR LYS VAL ASN ASP THR SER SEQRES 10 I 485 ASP ILE ILE GLY ASN ILE THR ASP ASP VAL ARG ASN CYS SEQRES 11 I 485 SER PHE ASN MET THR THR GLU LEU ARG ASP LYS GLN GLN SEQRES 12 I 485 LYS VAL TYR ALA LEU PHE TYR LYS LEU ASP ILE VAL PRO SEQRES 13 I 485 ILE ASP ASP SER SER ASN ASN GLY SER SER ASN PHE SER SEQRES 14 I 485 GLU TYR ARG LEU ILE ASN CYS ASN THR SER VAL ILE LYS SEQRES 15 I 485 GLN ALA CYS PRO LYS VAL SER PHE ASP PRO ILE PRO ILE SEQRES 16 I 485 HIS TYR CYS THR PRO ALA GLY TYR ALA ILE LEU ARG CYS SEQRES 17 I 485 ASN ASP LYS LYS PHE ASN GLY THR GLY PRO CYS LYS ASN SEQRES 18 I 485 VAL SER SER VAL GLN CYS THR HIS GLY ILE LYS PRO VAL SEQRES 19 I 485 VAL SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA GLU SEQRES 20 I 485 GLU GLY ILE ILE ILE ARG SER GLU ASN LEU THR ASN ASN SEQRES 21 I 485 ALA LYS THR ILE ILE VAL HIS PHE ASN GLU SER VAL LYS SEQRES 22 I 485 ILE ASN CYS THR ARG PRO SER ASN ASN THR ARG THR GLY SEQRES 23 I 485 ILE HIS ILE GLY PRO GLY GLN VAL PHE TYR LYS THR GLY SEQRES 24 I 485 ASP ILE ILE GLY ASP ILE ARG LYS ALA TYR CYS ASN ILE SEQRES 25 I 485 SER GLY ALA GLN TRP HIS LYS VAL LEU GLY ARG VAL ALA SEQRES 26 I 485 ASN LYS LEU LYS GLU HIS PHE ASN ASN LYS THR ILE VAL SEQRES 27 I 485 PHE LYS PRO SER SER GLY GLY ASP PRO GLU ILE THR MET SEQRES 28 I 485 HIS SER PHE ASN CYS ARG GLY GLU PHE PHE TYR CYS ASN SEQRES 29 I 485 THR THR LYS LEU PHE ASN SER THR TRP GLY GLY ASN LYS SEQRES 30 I 485 ASN GLU THR ARG ASP ASN GLY THR ILE THR ILE PRO CYS SEQRES 31 I 485 ARG ILE LYS GLN ILE ILE ASN MET TRP GLN GLY VAL GLY SEQRES 32 I 485 GLN ALA MET TYR ALA PRO PRO ILE LYS GLY VAL ILE LYS SEQRES 33 I 485 CYS LEU SER ASN ILE THR GLY ILE LEU LEU THR ARG ASP SEQRES 34 I 485 GLY GLY ASN ASP THR GLU ASN ASN GLU THR PHE ARG PRO SEQRES 35 I 485 GLY GLY GLY ASP MET ARG ASP ASN TRP ARG ASN GLU LEU SEQRES 36 I 485 TYR LYS TYR LYS VAL VAL GLN ILE GLU PRO LEU GLY ILE SEQRES 37 I 485 ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLU ARG ARG SEQRES 38 I 485 ARG ARG ARG ARG SEQRES 1 J 155 ALA VAL GLY LEU GLY ALA MET ILE PHE GLY PHE LEU GLY SEQRES 2 J 155 ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR LEU SEQRES 3 J 155 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 J 155 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 J 155 HIS LEU LEU GLN LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 J 155 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU GLN ASP SEQRES 7 J 155 GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS ILE SEQRES 8 J 155 ILE CYS CYS THR ALA VAL PRO TRP ASN SER SER TRP SER SEQRES 9 J 155 ASN LYS THR PHE GLU GLU ILE TRP ASN ASN MET THR TRP SEQRES 10 J 155 ILE GLU TRP GLU ARG GLU ILE SER ASN TYR THR SER GLN SEQRES 11 J 155 ILE TYR ASP ILE LEU THR ILE SER GLN THR GLN GLN GLU SEQRES 12 J 155 LYS ASN GLU LYS ASP LEU LEU GLU LEU ASP ALA ALA SEQRES 1 K 238 GLN ILE HIS LEU VAL GLN SER GLY THR GLU VAL LYS LYS SEQRES 2 K 238 PRO GLY SER SER VAL THR VAL SER CYS LYS ALA TYR GLY SEQRES 3 K 238 VAL ASN THR PHE GLY LEU TYR ALA VAL ASN TRP VAL ARG SEQRES 4 K 238 GLN ALA PRO GLY GLN SER LEU GLU TYR ILE GLY GLN ILE SEQRES 5 K 238 TRP ARG TRP LYS SER SER ALA SER HIS HIS PHE ARG GLY SEQRES 6 K 238 ARG VAL LEU ILE SER ALA VAL ASP LEU THR GLY SER SER SEQRES 7 K 238 PRO PRO ILE SER SER LEU GLU ILE LYS ASN LEU THR SER SEQRES 8 K 238 ASP ASP THR ALA VAL TYR PHE CYS THR THR THR SER THR SEQRES 9 K 238 TYR ASP ARG TRP SER GLY LEU HIS HIS ASP GLY VAL MET SEQRES 10 K 238 ALA PHE SER SER TRP GLY GLN GLY THR LEU ILE SER VAL SEQRES 11 K 238 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 K 238 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 K 238 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 K 238 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 K 238 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 K 238 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 K 238 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 K 238 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 K 238 CYS ASP LYS THR SEQRES 1 L 215 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 L 215 SER THR GLY ASP THR VAL ARG ILE SER CYS ARG ALA SER SEQRES 3 L 215 GLN SER ILE THR GLY ASN TRP VAL ALA TRP TYR GLN GLN SEQRES 4 L 215 ARG PRO GLY LYS ALA PRO ARG LEU LEU ILE TYR ARG GLY SEQRES 5 L 215 ALA ALA LEU LEU GLY GLY VAL PRO SER ARG PHE ARG GLY SEQRES 6 L 215 SER ALA ALA GLY THR ASP PHE THR LEU THR ILE GLY ASN SEQRES 7 L 215 LEU GLN ALA GLU ASP PHE GLY THR PHE TYR CYS GLN GLN SEQRES 8 L 215 TYR ASP THR TYR PRO GLY THR PHE GLY GLN GLY THR LYS SEQRES 9 L 215 VAL GLU VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 Q 238 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 Q 238 PRO SER GLU THR LEU SER VAL THR CYS SER VAL SER GLY SEQRES 3 Q 238 ASP SER MET ASN ASN TYR TYR TRP THR TRP ILE ARG GLN SEQRES 4 Q 238 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR ILE SER SEQRES 5 Q 238 ASP ARG GLU SER ALA THR TYR ASN PRO SER LEU ASN SER SEQRES 6 Q 238 ARG VAL VAL ILE SER ARG ASP THR SER LYS ASN GLN LEU SEQRES 7 Q 238 SER LEU LYS LEU ASN SER VAL THR PRO ALA ASP THR ALA SEQRES 8 Q 238 VAL TYR TYR CYS ALA THR ALA ARG ARG GLY GLN ARG ILE SEQRES 9 Q 238 TYR GLY VAL VAL SER PHE GLY GLU PHE PHE TYR TYR TYR SEQRES 10 Q 238 SER MET ASP VAL TRP GLY LYS GLY THR THR VAL THR VAL SEQRES 11 Q 238 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 Q 238 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 Q 238 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 Q 238 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 Q 238 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 Q 238 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 Q 238 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 Q 238 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 Q 238 CYS ASP LYS THR SEQRES 1 R 214 SER TYR VAL ARG PRO LEU SER VAL ALA LEU GLY GLU THR SEQRES 2 R 214 ALA ARG ILE SER CYS GLY ARG GLN ALA LEU GLY SER ARG SEQRES 3 R 214 ALA VAL GLN TRP TYR GLN HIS ARG PRO GLY GLN ALA PRO SEQRES 4 R 214 ILE LEU LEU ILE TYR ASN ASN GLN ASP ARG PRO SER GLY SEQRES 5 R 214 ILE PRO GLU ARG PHE SER GLY THR PRO ASP ILE ASN PHE SEQRES 6 R 214 GLY THR ARG ALA THR LEU THR ILE SER GLY VAL GLU ALA SEQRES 7 R 214 GLY ASP GLU ALA ASP TYR TYR CYS HIS MET TRP ASP SER SEQRES 8 R 214 ARG SER GLY PHE SER TRP SER PHE GLY GLY ALA THR ARG SEQRES 9 R 214 LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 R 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 R 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 R 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 R 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 R 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 R 214 THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER CYS SEQRES 16 R 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 R 214 ALA PRO THR GLU CYS SER HET NAG S 1 14 HET NAG S 2 14 HET BMA S 3 11 HET MAN S 4 11 HET MAN S 5 11 HET MAN S 6 11 HET MAN S 7 11 HET MAN S 8 11 HET MAN S 9 11 HET MAN S 10 11 HET MAN S 11 11 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET MAN T 4 11 HET MAN T 5 11 HET MAN T 6 11 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET MAN U 6 11 HET MAN U 7 11 HET MAN U 8 11 HET MAN U 9 11 HET MAN U 10 11 HET NAG V 1 14 HET NAG V 2 14 HET NAG X 1 14 HET NAG X 2 14 HET NAG Y 1 14 HET NAG Y 2 14 HET BMA Y 3 11 HET MAN Y 4 11 HET MAN Y 5 11 HET MAN Y 6 11 HET NAG Z 1 14 HET NAG Z 2 14 HET BMA Z 3 11 HET MAN Z 4 11 HET MAN Z 5 11 HET NAG a 1 14 HET NAG a 2 14 HET BMA a 3 11 HET MAN a 4 11 HET MAN a 5 11 HET MAN a 6 11 HET MAN a 7 11 HET MAN a 8 11 HET MAN a 9 11 HET MAN a 10 11 HET MAN a 11 11 HET NAG b 1 14 HET NAG b 2 14 HET BMA b 3 11 HET MAN b 4 11 HET MAN b 5 11 HET MAN b 6 11 HET NAG c 1 14 HET NAG c 2 14 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET MAN d 4 11 HET MAN d 5 11 HET MAN d 6 11 HET MAN d 7 11 HET MAN d 8 11 HET MAN d 9 11 HET MAN d 10 11 HET NAG f 1 14 HET NAG f 2 14 HET NAG e 1 14 HET NAG e 2 14 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET BMA h 3 11 HET MAN h 4 11 HET MAN h 5 11 HET MAN h 6 11 HET NAG i 1 14 HET NAG i 2 14 HET BMA i 3 11 HET MAN i 4 11 HET MAN i 5 11 HET NAG j 1 14 HET NAG j 2 14 HET BMA j 3 11 HET MAN j 4 11 HET MAN j 5 11 HET MAN j 6 11 HET MAN j 7 11 HET MAN j 8 11 HET MAN j 9 11 HET MAN j 10 11 HET MAN j 11 11 HET NAG k 1 14 HET NAG k 2 14 HET BMA k 3 11 HET MAN k 4 11 HET MAN k 5 11 HET MAN k 6 11 HET NAG l 1 14 HET NAG l 2 14 HET NAG m 1 14 HET NAG m 2 14 HET NAG n 1 14 HET NAG n 2 14 HET BMA n 3 11 HET MAN n 4 11 HET MAN n 5 11 HET MAN n 6 11 HET MAN n 7 11 HET MAN n 8 11 HET MAN n 9 11 HET MAN n 10 11 HET NAG o 1 14 HET NAG o 2 14 HET NAG p 1 14 HET NAG p 2 14 HET NAG q 1 14 HET NAG q 2 14 HET NAG r 1 14 HET NAG r 2 14 HET BMA r 3 11 HET MAN r 4 11 HET MAN r 5 11 HET MAN r 6 11 HET NAG s 1 14 HET NAG s 2 14 HET BMA s 3 11 HET MAN s 4 11 HET MAN s 5 11 HET NAG t 1 14 HET NAG t 2 14 HET NAG u 1 14 HET NAG u 2 14 HET NAG v 1 14 HET NAG v 2 14 HET NAG w 1 14 HET NAG w 2 14 HET NAG x 1 14 HET NAG x 2 14 HET NAG y 1 14 HET NAG y 2 14 HET NAG z 1 14 HET NAG z 2 14 HET NAG 0 1 14 HET NAG 0 2 14 HET NAG 1 1 14 HET NAG 1 2 14 HET NAG 2 1 14 HET NAG 2 2 14 HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG A 604 14 HET NAG A 605 14 HET NAG A 606 14 HET NAG A 607 14 HET NAG A 608 14 HET NAG A 609 14 HET NAG B 700 14 HET NAG B 701 14 HET NAG B 702 14 HET NAG E 601 14 HET NAG E 602 14 HET NAG E 603 14 HET NAG E 604 14 HET NAG E 605 14 HET NAG E 606 14 HET NAG E 607 14 HET NAG E 608 14 HET NAG E 609 14 HET NAG F 700 14 HET NAG F 701 14 HET NAG F 702 14 HET NAG I 601 14 HET NAG I 602 14 HET NAG I 603 14 HET NAG I 604 14 HET NAG I 605 14 HET NAG I 606 14 HET NAG I 607 14 HET NAG I 608 14 HET NAG I 609 14 HET NAG J 700 14 HET NAG J 701 14 HET NAG J 702 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 19 NAG 108(C8 H15 N O6) FORMUL 19 BMA 15(C6 H12 O6) FORMUL 19 MAN 69(C6 H12 O6) HELIX 1 AA1 TRP A 96 ASN A 98 5 3 HELIX 2 AA2 ASN A 99 LYS A 117 1 19 HELIX 3 AA3 SER A 334 PHE A 353 1 20 HELIX 4 AA4 ASP A 368 MET A 373 1 6 HELIX 5 AA5 ARG A 476 ASN A 481 1 6 HELIX 6 AA6 THR B 529 LEU B 537 1 9 HELIX 7 AA7 THR B 569 TRP B 596 1 28 HELIX 8 AA8 THR B 618 ASN B 625 1 8 HELIX 9 AA9 THR B 627 ILE B 635 1 9 HELIX 10 AB1 TYR B 638 LEU B 661 1 24 HELIX 11 AB2 THR C 83 THR C 87 5 5 HELIX 12 AB3 GLN D 79 PHE D 83 5 5 HELIX 13 AB4 THR M 83 THR M 87 5 5 HELIX 14 AB5 VAL M 100D GLY M 100H 5 5 HELIX 15 AB6 GLU N 79 ALA N 84 1 6 HELIX 16 AB7 TRP E 96 ASN E 98 5 3 HELIX 17 AB8 ASN E 99 LYS E 117 1 19 HELIX 18 AB9 SER E 334 PHE E 353 1 20 HELIX 19 AC1 ASP E 368 MET E 373 1 6 HELIX 20 AC2 ARG E 476 ASN E 481 1 6 HELIX 21 AC3 THR F 529 LEU F 537 1 9 HELIX 22 AC4 THR F 569 TRP F 596 1 28 HELIX 23 AC5 THR F 618 ASN F 625 1 8 HELIX 24 AC6 THR F 627 ILE F 635 1 9 HELIX 25 AC7 TYR F 638 LEU F 661 1 24 HELIX 26 AC8 THR G 83 THR G 87 5 5 HELIX 27 AC9 GLN H 79 PHE H 83 5 5 HELIX 28 AD1 THR O 83 THR O 87 5 5 HELIX 29 AD2 VAL O 100D GLY O 100H 5 5 HELIX 30 AD3 GLU P 79 ALA P 84 1 6 HELIX 31 AD4 TRP I 96 ASN I 98 5 3 HELIX 32 AD5 ASN I 99 LYS I 117 1 19 HELIX 33 AD6 SER I 334 PHE I 353 1 20 HELIX 34 AD7 ASP I 368 MET I 373 1 6 HELIX 35 AD8 ARG I 476 ASN I 481 1 6 HELIX 36 AD9 THR J 529 LEU J 537 1 9 HELIX 37 AE1 THR J 569 TRP J 596 1 28 HELIX 38 AE2 THR J 618 ASN J 625 1 8 HELIX 39 AE3 THR J 627 ILE J 635 1 9 HELIX 40 AE4 TYR J 638 LEU J 661 1 24 HELIX 41 AE5 THR K 83 THR K 87 5 5 HELIX 42 AE6 GLN L 79 PHE L 83 5 5 HELIX 43 AE7 THR Q 83 THR Q 87 5 5 HELIX 44 AE8 VAL Q 100D GLY Q 100H 5 5 HELIX 45 AE9 GLU R 79 ALA R 84 1 6 SHEET 1 AA1 3 LEU A 494 THR A 499 0 SHEET 2 AA1 3 TRP A 35 TYR A 40 -1 N TRP A 35 O THR A 499 SHEET 3 AA1 3 ILE B 603 CYS B 605 -1 O CYS B 604 N VAL A 38 SHEET 1 AA2 5 TRP A 45 ASP A 47 0 SHEET 2 AA2 5 VAL A 488 ILE A 491 -1 O GLN A 490 N ARG A 46 SHEET 3 AA2 5 TYR A 223 ARG A 227 -1 N ALA A 224 O VAL A 489 SHEET 4 AA2 5 VAL A 242 VAL A 245 -1 O SER A 243 N ARG A 227 SHEET 5 AA2 5 MET A 84 LEU A 86 -1 N MET A 84 O SER A 244 SHEET 1 AA3 2 ASN A 92 ASN A 94 0 SHEET 2 AA3 2 THR A 236 PRO A 238 -1 O GLY A 237 N PHE A 93 SHEET 1 AA4 2 ARG A 155 THR A 162 0 SHEET 2 AA4 2 GLN A 169 PHE A 176 -1 O GLN A 170 N MET A 161 SHEET 1 AA5 2 ILE A 181 PRO A 183 0 SHEET 2 AA5 2 TYR A 191 LEU A 193 -1 O ARG A 192 N VAL A 182 SHEET 1 AA6 6 ILE A 271 ARG A 273 0 SHEET 2 AA6 6 ILE A 284 HIS A 287 -1 O HIS A 287 N ILE A 271 SHEET 3 AA6 6 ILE A 452 ARG A 456 -1 O LEU A 454 N ILE A 284 SHEET 4 AA6 6 ASN A 465 PRO A 470 -1 O ARG A 469 N THR A 455 SHEET 5 AA6 6 THR A 357 PHE A 361 1 N VAL A 360 O PHE A 468 SHEET 6 AA6 6 SER A 393 TRP A 395 -1 O TRP A 395 N ILE A 358 SHEET 1 AA7 4 ILE A 414 PRO A 417 0 SHEET 2 AA7 4 TYR A 330 ILE A 333 -1 N ILE A 333 O ILE A 414 SHEET 3 AA7 4 VAL A 292 ARG A 298 -1 N ASN A 295 O ASN A 332 SHEET 4 AA7 4 ILE A 443 ILE A 449 -1 O SER A 447 N ILE A 294 SHEET 1 AA8 2 ARG A 304 HIS A 308 0 SHEET 2 AA8 2 VAL A 316 THR A 320 -1 O PHE A 317 N ILE A 307 SHEET 1 AA9 2 ILE A 423 ILE A 424 0 SHEET 2 AA9 2 MET A 434 TYR A 435 -1 O MET A 434 N ILE A 424 SHEET 1 AB1 4 HIS C 3 GLN C 6 0 SHEET 2 AB1 4 VAL C 18 TYR C 25 -1 O TYR C 25 N HIS C 3 SHEET 3 AB1 4 ILE C 77D ILE C 82 -1 O LEU C 80 N VAL C 20 SHEET 4 AB1 4 VAL C 67 VAL C 72 -1 N VAL C 72 O ILE C 77D SHEET 1 AB2 2 GLU C 10 VAL C 11 0 SHEET 2 AB2 2 ILE C 109 SER C 110 1 O SER C 110 N GLU C 10 SHEET 1 AB3 5 SER C 57 ALA C 59 0 SHEET 2 AB3 5 LEU C 45 TRP C 52 -1 N GLN C 50 O SER C 58 SHEET 3 AB3 5 TYR C 33 GLN C 39 -1 N ARG C 38 O GLU C 46 SHEET 4 AB3 5 VAL C 89 SER C 96 -1 O THR C 93 N ASN C 35A SHEET 5 AB3 5 SER C 102 TRP C 103 -1 O SER C 102 N THR C 94 SHEET 1 AB4 2 HIS C 100E HIS C 100F 0 SHEET 2 AB4 2 VAL C 100I MET C 100J-1 O VAL C 100I N HIS C 100F SHEET 1 AB5 6 THR D 10 SER D 12 0 SHEET 2 AB5 6 THR D 102 GLU D 105 1 O LYS D 103 N LEU D 11 SHEET 3 AB5 6 THR D 85 GLN D 90 -1 N PHE D 86 O THR D 102 SHEET 4 AB5 6 VAL D 33 GLN D 38 -1 N TYR D 36 O TYR D 87 SHEET 5 AB5 6 PRO D 44 TYR D 49 -1 O ILE D 48 N TRP D 35 SHEET 6 AB5 6 ALA D 53 LEU D 54 -1 O ALA D 53 N TYR D 49 SHEET 1 AB6 3 VAL D 19 ARG D 24 0 SHEET 2 AB6 3 ASP D 70 ILE D 75 -1 O LEU D 73 N ILE D 21 SHEET 3 AB6 3 PHE D 62 ALA D 67 -1 N ARG D 63 O THR D 74 SHEET 1 AB7 2 LEU M 4 SER M 7 0 SHEET 2 AB7 2 THR M 21 VAL M 24 -1 O THR M 21 N SER M 7 SHEET 1 AB8 5 LEU M 11 VAL M 12 0 SHEET 2 AB8 5 THR M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AB8 5 ALA M 88 ARG M 100 -1 N ALA M 88 O VAL M 109 SHEET 4 AB8 5 TYR M 33 ARG M 38 -1 N TYR M 33 O ALA M 95 SHEET 5 AB8 5 GLU M 46 ILE M 51 -1 O GLU M 46 N ARG M 38 SHEET 1 AB9 4 LEU M 11 VAL M 12 0 SHEET 2 AB9 4 THR M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AB9 4 ALA M 88 ARG M 100 -1 N ALA M 88 O VAL M 109 SHEET 4 AB9 4 PHE M 100K SER M 100O-1 O TYR M 100M N GLY M 98 SHEET 1 AC1 4 ILE N 45 LEU N 46 0 SHEET 2 AC1 4 ALA N 32 GLN N 37 -1 N GLN N 37 O ILE N 45 SHEET 3 AC1 4 TYR N 86 TRP N 91 -1 O HIS N 89 N GLN N 34 SHEET 4 AC1 4 ALA N 101 THR N 102 -1 O THR N 102 N TYR N 86 SHEET 1 AC2 3 LEU E 494 THR E 499 0 SHEET 2 AC2 3 TRP E 35 TYR E 40 -1 N TRP E 35 O THR E 499 SHEET 3 AC2 3 ILE F 603 CYS F 605 -1 O CYS F 604 N VAL E 38 SHEET 1 AC3 5 TRP E 45 ASP E 47 0 SHEET 2 AC3 5 VAL E 488 ILE E 491 -1 O GLN E 490 N ARG E 46 SHEET 3 AC3 5 TYR E 223 ARG E 227 -1 N ALA E 224 O VAL E 489 SHEET 4 AC3 5 VAL E 242 VAL E 245 -1 O SER E 243 N ARG E 227 SHEET 5 AC3 5 MET E 84 LEU E 86 -1 N MET E 84 O SER E 244 SHEET 1 AC4 2 ASN E 92 ASN E 94 0 SHEET 2 AC4 2 THR E 236 PRO E 238 -1 O GLY E 237 N PHE E 93 SHEET 1 AC5 2 ARG E 155 THR E 162 0 SHEET 2 AC5 2 GLN E 169 PHE E 176 -1 O GLN E 170 N MET E 161 SHEET 1 AC6 2 ILE E 181 PRO E 183 0 SHEET 2 AC6 2 TYR E 191 LEU E 193 -1 O ARG E 192 N VAL E 182 SHEET 1 AC7 6 ILE E 271 ARG E 273 0 SHEET 2 AC7 6 ILE E 284 HIS E 287 -1 O HIS E 287 N ILE E 271 SHEET 3 AC7 6 ILE E 452 ARG E 456 -1 O LEU E 454 N ILE E 284 SHEET 4 AC7 6 ASN E 465 PRO E 470 -1 O ARG E 469 N THR E 455 SHEET 5 AC7 6 THR E 357 PHE E 361 1 N VAL E 360 O PHE E 468 SHEET 6 AC7 6 SER E 393 TRP E 395 -1 O TRP E 395 N ILE E 358 SHEET 1 AC8 4 ILE E 414 PRO E 417 0 SHEET 2 AC8 4 TYR E 330 ILE E 333 -1 N ILE E 333 O ILE E 414 SHEET 3 AC8 4 VAL E 292 ARG E 298 -1 N ASN E 295 O ASN E 332 SHEET 4 AC8 4 ILE E 443 ILE E 449 -1 O SER E 447 N ILE E 294 SHEET 1 AC9 2 ARG E 304 HIS E 308 0 SHEET 2 AC9 2 VAL E 316 THR E 320 -1 O PHE E 317 N ILE E 307 SHEET 1 AD1 2 ILE E 423 ILE E 424 0 SHEET 2 AD1 2 MET E 434 TYR E 435 -1 O MET E 434 N ILE E 424 SHEET 1 AD2 4 HIS G 3 GLN G 6 0 SHEET 2 AD2 4 VAL G 18 TYR G 25 -1 O TYR G 25 N HIS G 3 SHEET 3 AD2 4 ILE G 77D ILE G 82 -1 O LEU G 80 N VAL G 20 SHEET 4 AD2 4 VAL G 67 VAL G 72 -1 N VAL G 72 O ILE G 77D SHEET 1 AD3 2 GLU G 10 VAL G 11 0 SHEET 2 AD3 2 ILE G 109 SER G 110 1 O SER G 110 N GLU G 10 SHEET 1 AD4 5 SER G 57 ALA G 59 0 SHEET 2 AD4 5 LEU G 45 TRP G 52 -1 N GLN G 50 O SER G 58 SHEET 3 AD4 5 TYR G 33 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 4 AD4 5 VAL G 89 SER G 96 -1 O THR G 93 N ASN G 35A SHEET 5 AD4 5 SER G 102 TRP G 103 -1 O SER G 102 N THR G 94 SHEET 1 AD5 2 HIS G 100E HIS G 100F 0 SHEET 2 AD5 2 VAL G 100I MET G 100J-1 O VAL G 100I N HIS G 100F SHEET 1 AD6 6 THR H 10 SER H 12 0 SHEET 2 AD6 6 THR H 102 GLU H 105 1 O LYS H 103 N LEU H 11 SHEET 3 AD6 6 THR H 85 GLN H 90 -1 N PHE H 86 O THR H 102 SHEET 4 AD6 6 VAL H 33 GLN H 38 -1 N TYR H 36 O TYR H 87 SHEET 5 AD6 6 PRO H 44 TYR H 49 -1 O ILE H 48 N TRP H 35 SHEET 6 AD6 6 ALA H 53 LEU H 54 -1 O ALA H 53 N TYR H 49 SHEET 1 AD7 3 VAL H 19 ARG H 24 0 SHEET 2 AD7 3 ASP H 70 ILE H 75 -1 O LEU H 73 N ILE H 21 SHEET 3 AD7 3 PHE H 62 ALA H 67 -1 N ARG H 63 O THR H 74 SHEET 1 AD8 2 LEU O 4 SER O 7 0 SHEET 2 AD8 2 THR O 21 VAL O 24 -1 O THR O 21 N SER O 7 SHEET 1 AD9 5 LEU O 11 VAL O 12 0 SHEET 2 AD9 5 THR O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AD9 5 ALA O 88 ARG O 100 -1 N ALA O 88 O VAL O 109 SHEET 4 AD9 5 TYR O 33 ARG O 38 -1 N TYR O 33 O ALA O 95 SHEET 5 AD9 5 GLU O 46 ILE O 51 -1 O GLU O 46 N ARG O 38 SHEET 1 AE1 4 LEU O 11 VAL O 12 0 SHEET 2 AE1 4 THR O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AE1 4 ALA O 88 ARG O 100 -1 N ALA O 88 O VAL O 109 SHEET 4 AE1 4 PHE O 100K SER O 100O-1 O TYR O 100M N GLY O 98 SHEET 1 AE2 4 ILE P 45 LEU P 46 0 SHEET 2 AE2 4 ALA P 32 GLN P 37 -1 N GLN P 37 O ILE P 45 SHEET 3 AE2 4 TYR P 86 TRP P 91 -1 O HIS P 89 N GLN P 34 SHEET 4 AE2 4 ALA P 101 THR P 102 -1 O THR P 102 N TYR P 86 SHEET 1 AE3 3 LEU I 494 THR I 499 0 SHEET 2 AE3 3 TRP I 35 TYR I 40 -1 N TRP I 35 O THR I 499 SHEET 3 AE3 3 ILE J 603 CYS J 605 -1 O CYS J 604 N VAL I 38 SHEET 1 AE4 5 TRP I 45 ASP I 47 0 SHEET 2 AE4 5 VAL I 488 ILE I 491 -1 O GLN I 490 N ARG I 46 SHEET 3 AE4 5 TYR I 223 ARG I 227 -1 N ALA I 224 O VAL I 489 SHEET 4 AE4 5 VAL I 242 VAL I 245 -1 O SER I 243 N ARG I 227 SHEET 5 AE4 5 MET I 84 LEU I 86 -1 N MET I 84 O SER I 244 SHEET 1 AE5 2 ASN I 92 ASN I 94 0 SHEET 2 AE5 2 THR I 236 PRO I 238 -1 O GLY I 237 N PHE I 93 SHEET 1 AE6 2 ARG I 155 THR I 162 0 SHEET 2 AE6 2 GLN I 169 PHE I 176 -1 O GLN I 170 N MET I 161 SHEET 1 AE7 2 ILE I 181 PRO I 183 0 SHEET 2 AE7 2 TYR I 191 LEU I 193 -1 O ARG I 192 N VAL I 182 SHEET 1 AE8 6 ILE I 271 ARG I 273 0 SHEET 2 AE8 6 ILE I 284 HIS I 287 -1 O HIS I 287 N ILE I 271 SHEET 3 AE8 6 ILE I 452 ARG I 456 -1 O LEU I 454 N ILE I 284 SHEET 4 AE8 6 ASN I 465 PRO I 470 -1 O ARG I 469 N THR I 455 SHEET 5 AE8 6 THR I 357 PHE I 361 1 N VAL I 360 O PHE I 468 SHEET 6 AE8 6 SER I 393 TRP I 395 -1 O TRP I 395 N ILE I 358 SHEET 1 AE9 4 ILE I 414 PRO I 417 0 SHEET 2 AE9 4 TYR I 330 ILE I 333 -1 N ILE I 333 O ILE I 414 SHEET 3 AE9 4 VAL I 292 ARG I 298 -1 N ASN I 295 O ASN I 332 SHEET 4 AE9 4 ILE I 443 ILE I 449 -1 O SER I 447 N ILE I 294 SHEET 1 AF1 2 ARG I 304 HIS I 308 0 SHEET 2 AF1 2 VAL I 316 THR I 320 -1 O PHE I 317 N ILE I 307 SHEET 1 AF2 2 ILE I 423 ILE I 424 0 SHEET 2 AF2 2 MET I 434 TYR I 435 -1 O MET I 434 N ILE I 424 SHEET 1 AF3 4 HIS K 3 GLN K 6 0 SHEET 2 AF3 4 VAL K 18 TYR K 25 -1 O TYR K 25 N HIS K 3 SHEET 3 AF3 4 ILE K 77D ILE K 82 -1 O LEU K 80 N VAL K 20 SHEET 4 AF3 4 VAL K 67 VAL K 72 -1 N VAL K 72 O ILE K 77D SHEET 1 AF4 2 GLU K 10 VAL K 11 0 SHEET 2 AF4 2 ILE K 109 SER K 110 1 O SER K 110 N GLU K 10 SHEET 1 AF5 5 SER K 57 ALA K 59 0 SHEET 2 AF5 5 LEU K 45 TRP K 52 -1 N GLN K 50 O SER K 58 SHEET 3 AF5 5 TYR K 33 GLN K 39 -1 N ARG K 38 O GLU K 46 SHEET 4 AF5 5 VAL K 89 SER K 96 -1 O THR K 93 N ASN K 35A SHEET 5 AF5 5 SER K 102 TRP K 103 -1 O SER K 102 N THR K 94 SHEET 1 AF6 2 HIS K 100E HIS K 100F 0 SHEET 2 AF6 2 VAL K 100I MET K 100J-1 O VAL K 100I N HIS K 100F SHEET 1 AF7 6 THR L 10 SER L 12 0 SHEET 2 AF7 6 THR L 102 GLU L 105 1 O LYS L 103 N LEU L 11 SHEET 3 AF7 6 THR L 85 GLN L 90 -1 N PHE L 86 O THR L 102 SHEET 4 AF7 6 VAL L 33 GLN L 38 -1 N TYR L 36 O TYR L 87 SHEET 5 AF7 6 PRO L 44 TYR L 49 -1 O ILE L 48 N TRP L 35 SHEET 6 AF7 6 ALA L 53 LEU L 54 -1 O ALA L 53 N TYR L 49 SHEET 1 AF8 3 VAL L 19 ARG L 24 0 SHEET 2 AF8 3 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 3 AF8 3 PHE L 62 ALA L 67 -1 N ARG L 63 O THR L 74 SHEET 1 AF9 2 LEU Q 4 SER Q 7 0 SHEET 2 AF9 2 THR Q 21 VAL Q 24 -1 O THR Q 21 N SER Q 7 SHEET 1 AG1 5 LEU Q 11 VAL Q 12 0 SHEET 2 AG1 5 THR Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AG1 5 ALA Q 88 ARG Q 100 -1 N ALA Q 88 O VAL Q 109 SHEET 4 AG1 5 TYR Q 33 ARG Q 38 -1 N TYR Q 33 O ALA Q 95 SHEET 5 AG1 5 GLU Q 46 ILE Q 51 -1 O GLU Q 46 N ARG Q 38 SHEET 1 AG2 4 LEU Q 11 VAL Q 12 0 SHEET 2 AG2 4 THR Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AG2 4 ALA Q 88 ARG Q 100 -1 N ALA Q 88 O VAL Q 109 SHEET 4 AG2 4 PHE Q 100K SER Q 100O-1 O TYR Q 100M N GLY Q 98 SHEET 1 AG3 4 ILE R 45 LEU R 46 0 SHEET 2 AG3 4 ALA R 32 GLN R 37 -1 N GLN R 37 O ILE R 45 SHEET 3 AG3 4 TYR R 86 TRP R 91 -1 O HIS R 89 N GLN R 34 SHEET 4 AG3 4 ALA R 101 THR R 102 -1 O THR R 102 N TYR R 86 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.03 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.04 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.03 SSBOND 4 CYS A 131 CYS A 157 1555 1555 2.03 SSBOND 5 CYS A 218 CYS A 247 1555 1555 2.02 SSBOND 6 CYS A 228 CYS A 239 1555 1555 2.03 SSBOND 7 CYS A 296 CYS A 331 1555 1555 2.03 SSBOND 8 CYS A 378 CYS A 445 1555 1555 2.03 SSBOND 9 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 10 CYS A 501 CYS B 605 1555 1555 2.02 SSBOND 11 CYS B 598 CYS B 604 1555 1555 2.03 SSBOND 12 CYS C 22 CYS C 92 1555 1555 2.03 SSBOND 13 CYS D 23 CYS D 88 1555 1555 2.04 SSBOND 14 CYS M 22 CYS M 92 1555 1555 2.03 SSBOND 15 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 16 CYS E 54 CYS E 74 1555 1555 2.03 SSBOND 17 CYS E 119 CYS E 205 1555 1555 2.04 SSBOND 18 CYS E 126 CYS E 196 1555 1555 2.03 SSBOND 19 CYS E 131 CYS E 157 1555 1555 2.03 SSBOND 20 CYS E 218 CYS E 247 1555 1555 2.02 SSBOND 21 CYS E 228 CYS E 239 1555 1555 2.03 SSBOND 22 CYS E 296 CYS E 331 1555 1555 2.03 SSBOND 23 CYS E 378 CYS E 445 1555 1555 2.03 SSBOND 24 CYS E 385 CYS E 418 1555 1555 2.03 SSBOND 25 CYS E 501 CYS F 605 1555 1555 2.02 SSBOND 26 CYS F 598 CYS F 604 1555 1555 2.03 SSBOND 27 CYS G 22 CYS G 92 1555 1555 2.03 SSBOND 28 CYS H 23 CYS H 88 1555 1555 2.04 SSBOND 29 CYS O 22 CYS O 92 1555 1555 2.03 SSBOND 30 CYS P 23 CYS P 88 1555 1555 2.03 SSBOND 31 CYS I 54 CYS I 74 1555 1555 2.03 SSBOND 32 CYS I 119 CYS I 205 1555 1555 2.04 SSBOND 33 CYS I 126 CYS I 196 1555 1555 2.03 SSBOND 34 CYS I 131 CYS I 157 1555 1555 2.03 SSBOND 35 CYS I 218 CYS I 247 1555 1555 2.02 SSBOND 36 CYS I 228 CYS I 239 1555 1555 2.03 SSBOND 37 CYS I 296 CYS I 331 1555 1555 2.03 SSBOND 38 CYS I 378 CYS I 445 1555 1555 2.03 SSBOND 39 CYS I 385 CYS I 418 1555 1555 2.03 SSBOND 40 CYS I 501 CYS J 605 1555 1555 2.02 SSBOND 41 CYS J 598 CYS J 604 1555 1555 2.03 SSBOND 42 CYS K 22 CYS K 92 1555 1555 2.03 SSBOND 43 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 44 CYS Q 22 CYS Q 92 1555 1555 2.03 SSBOND 45 CYS R 23 CYS R 88 1555 1555 2.03 LINK ND2 ASN A 88 C1 NAG A 601 1555 1555 1.44 LINK ND2 ASN A 130 C1 NAG t 1 1555 1555 1.44 LINK ND2 ASN A 156 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN A 160 C1 NAG A 602 1555 1555 1.44 LINK ND2 ASN A 187 C1 NAG A 603 1555 1555 1.44 LINK ND2 ASN A 197 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN A 241 C1 NAG x 1 1555 1555 1.46 LINK ND2 ASN A 262 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN A 276 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN A 289 C1 NAG v 1 1555 1555 1.45 LINK ND2 ASN A 295 C1 NAG A 604 1555 1555 1.44 LINK ND2 ASN A 301 C1 NAG A 605 1555 1555 1.44 LINK ND2 ASN A 332 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN A 355 C1 NAG A 606 1555 1555 1.43 LINK ND2 ASN A 386 C1 NAG V 1 1555 1555 1.46 LINK ND2 ASN A 392 C1 NAG A 609 1555 1555 1.44 LINK ND2 ASN A 411 C1 NAG A 607 1555 1555 1.44 LINK ND2 ASN A 448 C1 NAG 0 1 1555 1555 1.46 LINK ND2 ASN A 465 C1 NAG A 608 1555 1555 1.44 LINK ND2 ASN B 611 C1 NAG B 700 1555 1555 1.45 LINK ND2 ASN B 616 C1 NAG B 701 1555 1555 1.44 LINK ND2 ASN B 625 C1 NAG B 702 1555 1555 1.45 LINK ND2 ASN B 637 C1 NAG Z 1 1555 1555 1.46 LINK ND2 ASN E 88 C1 NAG E 601 1555 1555 1.44 LINK ND2 ASN E 130 C1 NAG u 1 1555 1555 1.44 LINK ND2 ASN E 156 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN E 160 C1 NAG E 602 1555 1555 1.44 LINK ND2 ASN E 187 C1 NAG E 603 1555 1555 1.44 LINK ND2 ASN E 197 C1 NAG g 1 1555 1555 1.44 LINK ND2 ASN E 234 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN E 241 C1 NAG y 1 1555 1555 1.46 LINK ND2 ASN E 262 C1 NAG h 1 1555 1555 1.44 LINK ND2 ASN E 276 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN E 289 C1 NAG w 1 1555 1555 1.45 LINK ND2 ASN E 295 C1 NAG E 604 1555 1555 1.44 LINK ND2 ASN E 301 C1 NAG E 605 1555 1555 1.44 LINK ND2 ASN E 332 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN E 355 C1 NAG E 606 1555 1555 1.43 LINK ND2 ASN E 386 C1 NAG e 1 1555 1555 1.46 LINK ND2 ASN E 392 C1 NAG E 609 1555 1555 1.44 LINK ND2 ASN E 411 C1 NAG E 607 1555 1555 1.44 LINK ND2 ASN E 448 C1 NAG 1 1 1555 1555 1.46 LINK ND2 ASN E 465 C1 NAG E 608 1555 1555 1.44 LINK ND2 ASN F 611 C1 NAG F 700 1555 1555 1.45 LINK ND2 ASN F 616 C1 NAG F 701 1555 1555 1.44 LINK ND2 ASN F 625 C1 NAG F 702 1555 1555 1.45 LINK ND2 ASN F 637 C1 NAG i 1 1555 1555 1.46 LINK ND2 ASN I 88 C1 NAG I 601 1555 1555 1.44 LINK ND2 ASN I 130 C1 NAG q 1 1555 1555 1.44 LINK ND2 ASN I 156 C1 NAG l 1 1555 1555 1.44 LINK ND2 ASN I 160 C1 NAG I 602 1555 1555 1.44 LINK ND2 ASN I 187 C1 NAG I 603 1555 1555 1.44 LINK ND2 ASN I 197 C1 NAG p 1 1555 1555 1.44 LINK ND2 ASN I 234 C1 NAG j 1 1555 1555 1.44 LINK ND2 ASN I 241 C1 NAG z 1 1555 1555 1.46 LINK ND2 ASN I 262 C1 NAG r 1 1555 1555 1.44 LINK ND2 ASN I 276 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN I 289 C1 NAG m 1 1555 1555 1.45 LINK ND2 ASN I 295 C1 NAG I 604 1555 1555 1.44 LINK ND2 ASN I 301 C1 NAG I 605 1555 1555 1.44 LINK ND2 ASN I 332 C1 NAG n 1 1555 1555 1.44 LINK ND2 ASN I 355 C1 NAG I 606 1555 1555 1.43 LINK ND2 ASN I 386 C1 NAG o 1 1555 1555 1.46 LINK ND2 ASN I 392 C1 NAG I 609 1555 1555 1.44 LINK ND2 ASN I 411 C1 NAG I 607 1555 1555 1.44 LINK ND2 ASN I 448 C1 NAG 2 1 1555 1555 1.46 LINK ND2 ASN I 465 C1 NAG I 608 1555 1555 1.44 LINK ND2 ASN J 611 C1 NAG J 700 1555 1555 1.45 LINK ND2 ASN J 616 C1 NAG J 701 1555 1555 1.44 LINK ND2 ASN J 625 C1 NAG J 702 1555 1555 1.45 LINK ND2 ASN J 637 C1 NAG s 1 1555 1555 1.46 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.45 LINK O4 NAG S 2 C1 BMA S 3 1555 1555 1.44 LINK O3 BMA S 3 C1 MAN S 4 1555 1555 1.44 LINK O6 BMA S 3 C1 MAN S 7 1555 1555 1.44 LINK O2 MAN S 4 C1 MAN S 5 1555 1555 1.44 LINK O2 MAN S 5 C1 MAN S 6 1555 1555 1.45 LINK O3 MAN S 7 C1 MAN S 8 1555 1555 1.44 LINK O6 MAN S 7 C1 MAN S 10 1555 1555 1.44 LINK O2 MAN S 8 C1 MAN S 9 1555 1555 1.44 LINK O2 MAN S 10 C1 MAN S 11 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.43 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.44 LINK O3 BMA T 3 C1 MAN T 4 1555 1555 1.45 LINK O6 BMA T 3 C1 MAN T 6 1555 1555 1.44 LINK O2 MAN T 4 C1 MAN T 5 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.44 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.44 LINK O6 BMA U 3 C1 MAN U 7 1555 1555 1.44 LINK O2 MAN U 4 C1 MAN U 5 1555 1555 1.44 LINK O2 MAN U 5 C1 MAN U 6 1555 1555 1.45 LINK O6 MAN U 7 C1 MAN U 8 1555 1555 1.44 LINK O3 MAN U 7 C1 MAN U 10 1555 1555 1.44 LINK O2 MAN U 8 C1 MAN U 9 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.46 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.45 LINK O4 NAG Y 2 C1 BMA Y 3 1555 1555 1.44 LINK O3 BMA Y 3 C1 MAN Y 4 1555 1555 1.44 LINK O6 BMA Y 3 C1 MAN Y 6 1555 1555 1.44 LINK O2 MAN Y 4 C1 MAN Y 5 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG Z 2 C1 BMA Z 3 1555 1555 1.44 LINK O3 BMA Z 3 C1 MAN Z 4 1555 1555 1.44 LINK O6 BMA Z 3 C1 MAN Z 5 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 LINK O4 NAG a 2 C1 BMA a 3 1555 1555 1.44 LINK O3 BMA a 3 C1 MAN a 4 1555 1555 1.44 LINK O6 BMA a 3 C1 MAN a 7 1555 1555 1.44 LINK O2 MAN a 4 C1 MAN a 5 1555 1555 1.44 LINK O2 MAN a 5 C1 MAN a 6 1555 1555 1.45 LINK O3 MAN a 7 C1 MAN a 8 1555 1555 1.44 LINK O6 MAN a 7 C1 MAN a 10 1555 1555 1.44 LINK O2 MAN a 8 C1 MAN a 9 1555 1555 1.44 LINK O2 MAN a 10 C1 MAN a 11 1555 1555 1.44 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.44 LINK O4 NAG b 2 C1 BMA b 3 1555 1555 1.44 LINK O3 BMA b 3 C1 MAN b 4 1555 1555 1.44 LINK O6 BMA b 3 C1 MAN b 6 1555 1555 1.44 LINK O2 MAN b 4 C1 MAN b 5 1555 1555 1.44 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.44 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.44 LINK O3 BMA d 3 C1 MAN d 4 1555 1555 1.44 LINK O6 BMA d 3 C1 MAN d 7 1555 1555 1.44 LINK O2 MAN d 4 C1 MAN d 5 1555 1555 1.44 LINK O2 MAN d 5 C1 MAN d 6 1555 1555 1.45 LINK O6 MAN d 7 C1 MAN d 8 1555 1555 1.44 LINK O3 MAN d 7 C1 MAN d 10 1555 1555 1.44 LINK O2 MAN d 8 C1 MAN d 9 1555 1555 1.44 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.44 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.46 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.44 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.45 LINK O4 NAG h 2 C1 BMA h 3 1555 1555 1.44 LINK O3 BMA h 3 C1 MAN h 4 1555 1555 1.44 LINK O6 BMA h 3 C1 MAN h 6 1555 1555 1.44 LINK O2 MAN h 4 C1 MAN h 5 1555 1555 1.44 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.44 LINK O4 NAG i 2 C1 BMA i 3 1555 1555 1.44 LINK O3 BMA i 3 C1 MAN i 4 1555 1555 1.44 LINK O6 BMA i 3 C1 MAN i 5 1555 1555 1.44 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.45 LINK O4 NAG j 2 C1 BMA j 3 1555 1555 1.44 LINK O3 BMA j 3 C1 MAN j 4 1555 1555 1.44 LINK O6 BMA j 3 C1 MAN j 7 1555 1555 1.44 LINK O2 MAN j 4 C1 MAN j 5 1555 1555 1.44 LINK O2 MAN j 5 C1 MAN j 6 1555 1555 1.45 LINK O3 MAN j 7 C1 MAN j 8 1555 1555 1.44 LINK O6 MAN j 7 C1 MAN j 10 1555 1555 1.44 LINK O2 MAN j 8 C1 MAN j 9 1555 1555 1.44 LINK O2 MAN j 10 C1 MAN j 11 1555 1555 1.44 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.44 LINK O4 NAG k 2 C1 BMA k 3 1555 1555 1.44 LINK O3 BMA k 3 C1 MAN k 4 1555 1555 1.44 LINK O6 BMA k 3 C1 MAN k 6 1555 1555 1.44 LINK O2 MAN k 4 C1 MAN k 5 1555 1555 1.44 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.44 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.44 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.44 LINK O4 NAG n 2 C1 BMA n 3 1555 1555 1.44 LINK O3 BMA n 3 C1 MAN n 4 1555 1555 1.44 LINK O6 BMA n 3 C1 MAN n 7 1555 1555 1.44 LINK O2 MAN n 4 C1 MAN n 5 1555 1555 1.44 LINK O2 MAN n 5 C1 MAN n 6 1555 1555 1.45 LINK O6 MAN n 7 C1 MAN n 8 1555 1555 1.44 LINK O3 MAN n 7 C1 MAN n 10 1555 1555 1.44 LINK O2 MAN n 8 C1 MAN n 9 1555 1555 1.44 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.46 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.44 LINK O4 NAG q 1 C1 NAG q 2 1555 1555 1.44 LINK O4 NAG r 1 C1 NAG r 2 1555 1555 1.45 LINK O4 NAG r 2 C1 BMA r 3 1555 1555 1.44 LINK O3 BMA r 3 C1 MAN r 4 1555 1555 1.45 LINK O6 BMA r 3 C1 MAN r 6 1555 1555 1.44 LINK O2 MAN r 4 C1 MAN r 5 1555 1555 1.44 LINK O4 NAG s 1 C1 NAG s 2 1555 1555 1.44 LINK O4 NAG s 2 C1 BMA s 3 1555 1555 1.44 LINK O3 BMA s 3 C1 MAN s 4 1555 1555 1.44 LINK O6 BMA s 3 C1 MAN s 5 1555 1555 1.44 LINK O4 NAG t 1 C1 NAG t 2 1555 1555 1.44 LINK O4 NAG u 1 C1 NAG u 2 1555 1555 1.44 LINK O4 NAG v 1 C1 NAG v 2 1555 1555 1.44 LINK O4 NAG w 1 C1 NAG w 2 1555 1555 1.44 LINK O4 NAG x 1 C1 NAG x 2 1555 1555 1.44 LINK O4 NAG y 1 C1 NAG y 2 1555 1555 1.44 LINK O4 NAG z 1 C1 NAG z 2 1555 1555 1.44 LINK O4 NAG 0 1 C1 NAG 0 2 1555 1555 1.45 LINK O4 NAG 1 1 C1 NAG 1 2 1555 1555 1.45 LINK O4 NAG 2 1 C1 NAG 2 2 1555 1555 1.45 CISPEP 1 SER D 7 PRO D 8 0 -3.20 CISPEP 2 TYR D 94 PRO D 95 0 -1.15 CISPEP 3 SER H 7 PRO H 8 0 -3.19 CISPEP 4 TYR H 94 PRO H 95 0 -1.12 CISPEP 5 SER L 7 PRO L 8 0 -3.21 CISPEP 6 TYR L 94 PRO L 95 0 -1.07 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000