HEADER VIRAL PROTEIN 26-AUG-22 8GPI TITLE HIV-1 ENV X18 UFO IN COMPLEX WITH 8ANC195 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: 8ANC195 FAB HEAVY CHAIN; COMPND 3 CHAIN: A, D, H; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: 8ANC195 FAB LIGHT CHAIN; COMPND 7 CHAIN: C, E, L; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: X18 UFO GP41; COMPND 11 CHAIN: R, S, T, X, Y, Z; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: TRICHOPALPUS NIGRIBASIS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 2611032; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: TRICHOPALPUS NIGRIBASIS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 2611032; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 13 ORGANISM_TAXID: 11676; SOURCE 14 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 10029 KEYWDS ANTIBODY, HIV-1, ENV PROTEIN, COMPLEX, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR J.NIU,Y.W.XU,B.YANG JRNL AUTH J.NIU,Y.W.XU,B.YANG JRNL TITL STRUCTURE AND IMMUNE RECOGNITION OF ENV TIMERS FROM TWO ASIA JRNL TITL 2 PREVALENT HIV-1 CIRCULATING RECOMBINANT FORMS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.00 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.000 REMARK 3 NUMBER OF PARTICLES : 205630 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8GPI COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ. REMARK 100 THE DEPOSITION ID IS D_1300031849. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HIV-1 ENV X18 UFO IN COMPLEX REMARK 245 WITH 8ANC195 FAB; 8ANC195 FAB; REMARK 245 HIV-1 ENV X18 UFO REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 50.00 REMARK 245 ILLUMINATION MODE : SPOT SCAN REMARK 245 NOMINAL MAGNIFICATION : 22500 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, D, E, H, L, R, S, T, X, REMARK 350 AND CHAINS: Y, Z, B, F, G, I, J, K, M, REMARK 350 AND CHAINS: N, O, P, Q, U, V, W, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i, j, k, l, REMARK 350 AND CHAINS: m, n, o, p, q, r REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER A 130 REMARK 465 ALA A 131 REMARK 465 ALA A 132 REMARK 465 SER A 133 REMARK 465 THR A 134 REMARK 465 LYS A 135 REMARK 465 GLY A 136 REMARK 465 PRO A 137 REMARK 465 SER A 138 REMARK 465 VAL A 139 REMARK 465 PHE A 140 REMARK 465 PRO A 141 REMARK 465 LEU A 142 REMARK 465 ALA A 143 REMARK 465 PRO A 144 REMARK 465 SER A 145 REMARK 465 SER A 146 REMARK 465 LYS A 147 REMARK 465 SER A 148 REMARK 465 THR A 149 REMARK 465 SER A 150 REMARK 465 GLY A 151 REMARK 465 GLY A 152 REMARK 465 THR A 153 REMARK 465 ALA A 154 REMARK 465 ALA A 155 REMARK 465 LEU A 156 REMARK 465 GLY A 157 REMARK 465 CYS A 158 REMARK 465 LEU A 159 REMARK 465 VAL A 160 REMARK 465 LYS A 161 REMARK 465 ASP A 162 REMARK 465 TYR A 163 REMARK 465 PHE A 164 REMARK 465 PRO A 165 REMARK 465 GLU A 166 REMARK 465 PRO A 167 REMARK 465 VAL A 168 REMARK 465 THR A 169 REMARK 465 VAL A 170 REMARK 465 SER A 171 REMARK 465 TRP A 172 REMARK 465 ASN A 173 REMARK 465 SER A 174 REMARK 465 GLY A 175 REMARK 465 ALA A 176 REMARK 465 LEU A 177 REMARK 465 THR A 178 REMARK 465 SER A 179 REMARK 465 GLY A 180 REMARK 465 VAL A 181 REMARK 465 HIS A 182 REMARK 465 THR A 183 REMARK 465 PHE A 184 REMARK 465 PRO A 185 REMARK 465 ALA A 186 REMARK 465 VAL A 187 REMARK 465 LEU A 188 REMARK 465 GLN A 189 REMARK 465 SER A 190 REMARK 465 SER A 191 REMARK 465 GLY A 192 REMARK 465 LEU A 193 REMARK 465 TYR A 194 REMARK 465 SER A 195 REMARK 465 LEU A 196 REMARK 465 SER A 197 REMARK 465 SER A 198 REMARK 465 VAL A 199 REMARK 465 VAL A 200 REMARK 465 THR A 201 REMARK 465 VAL A 202 REMARK 465 PRO A 203 REMARK 465 SER A 204 REMARK 465 SER A 205 REMARK 465 SER A 206 REMARK 465 LEU A 207 REMARK 465 GLY A 208 REMARK 465 THR A 209 REMARK 465 GLN A 210 REMARK 465 THR A 211 REMARK 465 TYR A 212 REMARK 465 ILE A 213 REMARK 465 CYS A 214 REMARK 465 ASN A 215 REMARK 465 VAL A 216 REMARK 465 ASN A 217 REMARK 465 HIS A 218 REMARK 465 LYS A 219 REMARK 465 PRO A 220 REMARK 465 SER A 221 REMARK 465 ASN A 222 REMARK 465 THR A 223 REMARK 465 LYS A 224 REMARK 465 VAL A 225 REMARK 465 ASP A 226 REMARK 465 LYS A 227 REMARK 465 LYS A 228 REMARK 465 VAL A 229 REMARK 465 GLU A 230 REMARK 465 PRO A 231 REMARK 465 LYS A 232 REMARK 465 SER A 233 REMARK 465 CYS A 234 REMARK 465 VAL C 106 REMARK 465 LYS C 107 REMARK 465 ARG C 108 REMARK 465 THR C 109 REMARK 465 VAL C 110 REMARK 465 ALA C 111 REMARK 465 ALA C 112 REMARK 465 PRO C 113 REMARK 465 SER C 114 REMARK 465 VAL C 115 REMARK 465 PHE C 116 REMARK 465 ILE C 117 REMARK 465 PHE C 118 REMARK 465 PRO C 119 REMARK 465 PRO C 120 REMARK 465 SER C 121 REMARK 465 ASP C 122 REMARK 465 GLU C 123 REMARK 465 GLN C 124 REMARK 465 LEU C 125 REMARK 465 LYS C 126 REMARK 465 SER C 127 REMARK 465 GLY C 128 REMARK 465 THR C 129 REMARK 465 ALA C 130 REMARK 465 SER C 131 REMARK 465 VAL C 132 REMARK 465 VAL C 133 REMARK 465 CYS C 134 REMARK 465 LEU C 135 REMARK 465 LEU C 136 REMARK 465 ASN C 137 REMARK 465 ASN C 138 REMARK 465 PHE C 139 REMARK 465 TYR C 140 REMARK 465 PRO C 141 REMARK 465 ARG C 142 REMARK 465 GLU C 143 REMARK 465 ALA C 144 REMARK 465 LYS C 145 REMARK 465 VAL C 146 REMARK 465 GLN C 147 REMARK 465 TRP C 148 REMARK 465 LYS C 149 REMARK 465 VAL C 150 REMARK 465 ASP C 151 REMARK 465 ASN C 152 REMARK 465 ALA C 153 REMARK 465 LEU C 154 REMARK 465 GLN C 155 REMARK 465 SER C 156 REMARK 465 GLY C 157 REMARK 465 ASN C 158 REMARK 465 SER C 159 REMARK 465 GLN C 160 REMARK 465 GLU C 161 REMARK 465 SER C 162 REMARK 465 VAL C 163 REMARK 465 THR C 164 REMARK 465 GLU C 165 REMARK 465 GLN C 166 REMARK 465 ASP C 167 REMARK 465 SER C 168 REMARK 465 LYS C 169 REMARK 465 ASP C 170 REMARK 465 SER C 171 REMARK 465 THR C 172 REMARK 465 TYR C 173 REMARK 465 SER C 174 REMARK 465 LEU C 175 REMARK 465 SER C 176 REMARK 465 SER C 177 REMARK 465 THR C 178 REMARK 465 LEU C 179 REMARK 465 THR C 180 REMARK 465 LEU C 181 REMARK 465 SER C 182 REMARK 465 LYS C 183 REMARK 465 ALA C 184 REMARK 465 ASP C 185 REMARK 465 TYR C 186 REMARK 465 GLU C 187 REMARK 465 LYS C 188 REMARK 465 HIS C 189 REMARK 465 LYS C 190 REMARK 465 VAL C 191 REMARK 465 TYR C 192 REMARK 465 ALA C 193 REMARK 465 CYS C 194 REMARK 465 GLU C 195 REMARK 465 VAL C 196 REMARK 465 THR C 197 REMARK 465 HIS C 198 REMARK 465 GLN C 199 REMARK 465 GLY C 200 REMARK 465 LEU C 201 REMARK 465 SER C 202 REMARK 465 SER C 203 REMARK 465 PRO C 204 REMARK 465 VAL C 205 REMARK 465 THR C 206 REMARK 465 LYS C 207 REMARK 465 SER C 208 REMARK 465 PHE C 209 REMARK 465 ASN C 210 REMARK 465 ARG C 211 REMARK 465 GLY C 212 REMARK 465 GLU C 213 REMARK 465 CYS C 214 REMARK 465 SER D 130 REMARK 465 ALA D 131 REMARK 465 ALA D 132 REMARK 465 SER D 133 REMARK 465 THR D 134 REMARK 465 LYS D 135 REMARK 465 GLY D 136 REMARK 465 PRO D 137 REMARK 465 SER D 138 REMARK 465 VAL D 139 REMARK 465 PHE D 140 REMARK 465 PRO D 141 REMARK 465 LEU D 142 REMARK 465 ALA D 143 REMARK 465 PRO D 144 REMARK 465 SER D 145 REMARK 465 SER D 146 REMARK 465 LYS D 147 REMARK 465 SER D 148 REMARK 465 THR D 149 REMARK 465 SER D 150 REMARK 465 GLY D 151 REMARK 465 GLY D 152 REMARK 465 THR D 153 REMARK 465 ALA D 154 REMARK 465 ALA D 155 REMARK 465 LEU D 156 REMARK 465 GLY D 157 REMARK 465 CYS D 158 REMARK 465 LEU D 159 REMARK 465 VAL D 160 REMARK 465 LYS D 161 REMARK 465 ASP D 162 REMARK 465 TYR D 163 REMARK 465 PHE D 164 REMARK 465 PRO D 165 REMARK 465 GLU D 166 REMARK 465 PRO D 167 REMARK 465 VAL D 168 REMARK 465 THR D 169 REMARK 465 VAL D 170 REMARK 465 SER D 171 REMARK 465 TRP D 172 REMARK 465 ASN D 173 REMARK 465 SER D 174 REMARK 465 GLY D 175 REMARK 465 ALA D 176 REMARK 465 LEU D 177 REMARK 465 THR D 178 REMARK 465 SER D 179 REMARK 465 GLY D 180 REMARK 465 VAL D 181 REMARK 465 HIS D 182 REMARK 465 THR D 183 REMARK 465 PHE D 184 REMARK 465 PRO D 185 REMARK 465 ALA D 186 REMARK 465 VAL D 187 REMARK 465 LEU D 188 REMARK 465 GLN D 189 REMARK 465 SER D 190 REMARK 465 SER D 191 REMARK 465 GLY D 192 REMARK 465 LEU D 193 REMARK 465 TYR D 194 REMARK 465 SER D 195 REMARK 465 LEU D 196 REMARK 465 SER D 197 REMARK 465 SER D 198 REMARK 465 VAL D 199 REMARK 465 VAL D 200 REMARK 465 THR D 201 REMARK 465 VAL D 202 REMARK 465 PRO D 203 REMARK 465 SER D 204 REMARK 465 SER D 205 REMARK 465 SER D 206 REMARK 465 LEU D 207 REMARK 465 GLY D 208 REMARK 465 THR D 209 REMARK 465 GLN D 210 REMARK 465 THR D 211 REMARK 465 TYR D 212 REMARK 465 ILE D 213 REMARK 465 CYS D 214 REMARK 465 ASN D 215 REMARK 465 VAL D 216 REMARK 465 ASN D 217 REMARK 465 HIS D 218 REMARK 465 LYS D 219 REMARK 465 PRO D 220 REMARK 465 SER D 221 REMARK 465 ASN D 222 REMARK 465 THR D 223 REMARK 465 LYS D 224 REMARK 465 VAL D 225 REMARK 465 ASP D 226 REMARK 465 LYS D 227 REMARK 465 LYS D 228 REMARK 465 VAL D 229 REMARK 465 GLU D 230 REMARK 465 PRO D 231 REMARK 465 LYS D 232 REMARK 465 SER D 233 REMARK 465 CYS D 234 REMARK 465 VAL E 106 REMARK 465 LYS E 107 REMARK 465 ARG E 108 REMARK 465 THR E 109 REMARK 465 VAL E 110 REMARK 465 ALA E 111 REMARK 465 ALA E 112 REMARK 465 PRO E 113 REMARK 465 SER E 114 REMARK 465 VAL E 115 REMARK 465 PHE E 116 REMARK 465 ILE E 117 REMARK 465 PHE E 118 REMARK 465 PRO E 119 REMARK 465 PRO E 120 REMARK 465 SER E 121 REMARK 465 ASP E 122 REMARK 465 GLU E 123 REMARK 465 GLN E 124 REMARK 465 LEU E 125 REMARK 465 LYS E 126 REMARK 465 SER E 127 REMARK 465 GLY E 128 REMARK 465 THR E 129 REMARK 465 ALA E 130 REMARK 465 SER E 131 REMARK 465 VAL E 132 REMARK 465 VAL E 133 REMARK 465 CYS E 134 REMARK 465 LEU E 135 REMARK 465 LEU E 136 REMARK 465 ASN E 137 REMARK 465 ASN E 138 REMARK 465 PHE E 139 REMARK 465 TYR E 140 REMARK 465 PRO E 141 REMARK 465 ARG E 142 REMARK 465 GLU E 143 REMARK 465 ALA E 144 REMARK 465 LYS E 145 REMARK 465 VAL E 146 REMARK 465 GLN E 147 REMARK 465 TRP E 148 REMARK 465 LYS E 149 REMARK 465 VAL E 150 REMARK 465 ASP E 151 REMARK 465 ASN E 152 REMARK 465 ALA E 153 REMARK 465 LEU E 154 REMARK 465 GLN E 155 REMARK 465 SER E 156 REMARK 465 GLY E 157 REMARK 465 ASN E 158 REMARK 465 SER E 159 REMARK 465 GLN E 160 REMARK 465 GLU E 161 REMARK 465 SER E 162 REMARK 465 VAL E 163 REMARK 465 THR E 164 REMARK 465 GLU E 165 REMARK 465 GLN E 166 REMARK 465 ASP E 167 REMARK 465 SER E 168 REMARK 465 LYS E 169 REMARK 465 ASP E 170 REMARK 465 SER E 171 REMARK 465 THR E 172 REMARK 465 TYR E 173 REMARK 465 SER E 174 REMARK 465 LEU E 175 REMARK 465 SER E 176 REMARK 465 SER E 177 REMARK 465 THR E 178 REMARK 465 LEU E 179 REMARK 465 THR E 180 REMARK 465 LEU E 181 REMARK 465 SER E 182 REMARK 465 LYS E 183 REMARK 465 ALA E 184 REMARK 465 ASP E 185 REMARK 465 TYR E 186 REMARK 465 GLU E 187 REMARK 465 LYS E 188 REMARK 465 HIS E 189 REMARK 465 LYS E 190 REMARK 465 VAL E 191 REMARK 465 TYR E 192 REMARK 465 ALA E 193 REMARK 465 CYS E 194 REMARK 465 GLU E 195 REMARK 465 VAL E 196 REMARK 465 THR E 197 REMARK 465 HIS E 198 REMARK 465 GLN E 199 REMARK 465 GLY E 200 REMARK 465 LEU E 201 REMARK 465 SER E 202 REMARK 465 SER E 203 REMARK 465 PRO E 204 REMARK 465 VAL E 205 REMARK 465 THR E 206 REMARK 465 LYS E 207 REMARK 465 SER E 208 REMARK 465 PHE E 209 REMARK 465 ASN E 210 REMARK 465 ARG E 211 REMARK 465 GLY E 212 REMARK 465 GLU E 213 REMARK 465 CYS E 214 REMARK 465 SER H 130 REMARK 465 ALA H 131 REMARK 465 ALA H 132 REMARK 465 SER H 133 REMARK 465 THR H 134 REMARK 465 LYS H 135 REMARK 465 GLY H 136 REMARK 465 PRO H 137 REMARK 465 SER H 138 REMARK 465 VAL H 139 REMARK 465 PHE H 140 REMARK 465 PRO H 141 REMARK 465 LEU H 142 REMARK 465 ALA H 143 REMARK 465 PRO H 144 REMARK 465 SER H 145 REMARK 465 SER H 146 REMARK 465 LYS H 147 REMARK 465 SER H 148 REMARK 465 THR H 149 REMARK 465 SER H 150 REMARK 465 GLY H 151 REMARK 465 GLY H 152 REMARK 465 THR H 153 REMARK 465 ALA H 154 REMARK 465 ALA H 155 REMARK 465 LEU H 156 REMARK 465 GLY H 157 REMARK 465 CYS H 158 REMARK 465 LEU H 159 REMARK 465 VAL H 160 REMARK 465 LYS H 161 REMARK 465 ASP H 162 REMARK 465 TYR H 163 REMARK 465 PHE H 164 REMARK 465 PRO H 165 REMARK 465 GLU H 166 REMARK 465 PRO H 167 REMARK 465 VAL H 168 REMARK 465 THR H 169 REMARK 465 VAL H 170 REMARK 465 SER H 171 REMARK 465 TRP H 172 REMARK 465 ASN H 173 REMARK 465 SER H 174 REMARK 465 GLY H 175 REMARK 465 ALA H 176 REMARK 465 LEU H 177 REMARK 465 THR H 178 REMARK 465 SER H 179 REMARK 465 GLY H 180 REMARK 465 VAL H 181 REMARK 465 HIS H 182 REMARK 465 THR H 183 REMARK 465 PHE H 184 REMARK 465 PRO H 185 REMARK 465 ALA H 186 REMARK 465 VAL H 187 REMARK 465 LEU H 188 REMARK 465 GLN H 189 REMARK 465 SER H 190 REMARK 465 SER H 191 REMARK 465 GLY H 192 REMARK 465 LEU H 193 REMARK 465 TYR H 194 REMARK 465 SER H 195 REMARK 465 LEU H 196 REMARK 465 SER H 197 REMARK 465 SER H 198 REMARK 465 VAL H 199 REMARK 465 VAL H 200 REMARK 465 THR H 201 REMARK 465 VAL H 202 REMARK 465 PRO H 203 REMARK 465 SER H 204 REMARK 465 SER H 205 REMARK 465 SER H 206 REMARK 465 LEU H 207 REMARK 465 GLY H 208 REMARK 465 THR H 209 REMARK 465 GLN H 210 REMARK 465 THR H 211 REMARK 465 TYR H 212 REMARK 465 ILE H 213 REMARK 465 CYS H 214 REMARK 465 ASN H 215 REMARK 465 VAL H 216 REMARK 465 ASN H 217 REMARK 465 HIS H 218 REMARK 465 LYS H 219 REMARK 465 PRO H 220 REMARK 465 SER H 221 REMARK 465 ASN H 222 REMARK 465 THR H 223 REMARK 465 LYS H 224 REMARK 465 VAL H 225 REMARK 465 ASP H 226 REMARK 465 LYS H 227 REMARK 465 LYS H 228 REMARK 465 VAL H 229 REMARK 465 GLU H 230 REMARK 465 PRO H 231 REMARK 465 LYS H 232 REMARK 465 SER H 233 REMARK 465 CYS H 234 REMARK 465 VAL L 106 REMARK 465 LYS L 107 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 ASN R 30 REMARK 465 LEU R 31 REMARK 465 TRP R 32 REMARK 465 VAL R 33 REMARK 465 THR R 34 REMARK 465 VAL R 35 REMARK 465 TYR R 36 REMARK 465 TYR R 37 REMARK 465 GLY R 38 REMARK 465 VAL R 39 REMARK 465 PRO R 40 REMARK 465 VAL R 41 REMARK 465 TRP R 42 REMARK 465 ARG R 43 REMARK 465 ASP R 44 REMARK 465 ALA R 45 REMARK 465 ASP R 46 REMARK 465 THR R 47 REMARK 465 THR R 48 REMARK 465 LEU R 49 REMARK 465 PHE R 50 REMARK 465 CYS R 51 REMARK 465 ALA R 52 REMARK 465 SER R 53 REMARK 465 ASP R 54 REMARK 465 ALA R 55 REMARK 465 LYS R 56 REMARK 465 ALA R 57 REMARK 465 HIS R 58 REMARK 465 VAL R 59 REMARK 465 PRO R 60 REMARK 465 GLU R 61 REMARK 465 ALA R 62 REMARK 465 HIS R 63 REMARK 465 ASN R 64 REMARK 465 VAL R 65 REMARK 465 TRP R 66 REMARK 465 ALA R 67 REMARK 465 THR R 68 REMARK 465 HIS R 69 REMARK 465 ALA R 70 REMARK 465 CYS R 71 REMARK 465 VAL R 72 REMARK 465 PRO R 73 REMARK 465 THR R 74 REMARK 465 ASP R 75 REMARK 465 PRO R 76 REMARK 465 ASN R 77 REMARK 465 PRO R 78 REMARK 465 GLN R 79 REMARK 465 GLU R 80 REMARK 465 ILE R 81 REMARK 465 PRO R 82 REMARK 465 LEU R 83 REMARK 465 GLU R 84 REMARK 465 ASN R 85 REMARK 465 VAL R 86 REMARK 465 THR R 87 REMARK 465 GLU R 88 REMARK 465 ASN R 89 REMARK 465 PHE R 90 REMARK 465 ASN R 91 REMARK 465 MET R 92 REMARK 465 TRP R 93 REMARK 465 LYS R 94 REMARK 465 ASN R 95 REMARK 465 ASN R 96 REMARK 465 MET R 97 REMARK 465 VAL R 98 REMARK 465 GLU R 99 REMARK 465 GLN R 100 REMARK 465 MET R 101 REMARK 465 GLN R 102 REMARK 465 GLU R 103 REMARK 465 ASP R 104 REMARK 465 VAL R 105 REMARK 465 ILE R 106 REMARK 465 SER R 107 REMARK 465 LEU R 108 REMARK 465 TRP R 109 REMARK 465 ASP R 110 REMARK 465 GLN R 111 REMARK 465 SER R 112 REMARK 465 LEU R 113 REMARK 465 LYS R 114 REMARK 465 PRO R 115 REMARK 465 CYS R 116 REMARK 465 VAL R 117 REMARK 465 LYS R 118 REMARK 465 LEU R 119 REMARK 465 THR R 120 REMARK 465 PRO R 121 REMARK 465 LEU R 122 REMARK 465 CYS R 123 REMARK 465 VAL R 124 REMARK 465 THR R 125 REMARK 465 LEU R 126 REMARK 465 ASN R 127 REMARK 465 CYS R 128 REMARK 465 THR R 129 REMARK 465 LYS R 130 REMARK 465 ALA R 131 REMARK 465 ASN R 132 REMARK 465 LEU R 133 REMARK 465 THR R 134 REMARK 465 HIS R 135 REMARK 465 ASN R 136 REMARK 465 THR R 137 REMARK 465 THR R 138 REMARK 465 ASN R 139 REMARK 465 ASP R 140 REMARK 465 LYS R 141 REMARK 465 ASN R 142 REMARK 465 GLY R 143 REMARK 465 THR R 144 REMARK 465 GLY R 145 REMARK 465 ASN R 146 REMARK 465 ILE R 147 REMARK 465 THR R 148 REMARK 465 ASP R 149 REMARK 465 GLU R 150 REMARK 465 VAL R 151 REMARK 465 LYS R 152 REMARK 465 ILE R 153 REMARK 465 GLY R 154 REMARK 465 ASN R 155 REMARK 465 ILE R 156 REMARK 465 THR R 157 REMARK 465 ASP R 158 REMARK 465 GLU R 159 REMARK 465 VAL R 160 REMARK 465 LYS R 161 REMARK 465 ASN R 162 REMARK 465 CYS R 163 REMARK 465 THR R 164 REMARK 465 PHE R 165 REMARK 465 ASN R 166 REMARK 465 MET R 167 REMARK 465 THR R 168 REMARK 465 THR R 169 REMARK 465 GLU R 170 REMARK 465 ILE R 171 REMARK 465 ARG R 172 REMARK 465 ASP R 173 REMARK 465 LYS R 174 REMARK 465 GLN R 175 REMARK 465 GLN R 176 REMARK 465 LYS R 177 REMARK 465 VAL R 178 REMARK 465 HIS R 179 REMARK 465 ALA R 180 REMARK 465 LEU R 181 REMARK 465 PHE R 182 REMARK 465 TYR R 183 REMARK 465 ALA R 184 REMARK 465 LEU R 185 REMARK 465 ASP R 186 REMARK 465 ILE R 187 REMARK 465 VAL R 188 REMARK 465 GLN R 189 REMARK 465 MET R 190 REMARK 465 LYS R 191 REMARK 465 GLU R 192 REMARK 465 ASN R 193 REMARK 465 GLY R 194 REMARK 465 SER R 195 REMARK 465 GLU R 196 REMARK 465 TYR R 197 REMARK 465 ARG R 198 REMARK 465 LEU R 199 REMARK 465 ILE R 200 REMARK 465 SER R 201 REMARK 465 CYS R 202 REMARK 465 ASN R 203 REMARK 465 THR R 204 REMARK 465 SER R 205 REMARK 465 VAL R 206 REMARK 465 ILE R 207 REMARK 465 LYS R 208 REMARK 465 GLN R 209 REMARK 465 ALA R 210 REMARK 465 CYS R 211 REMARK 465 PRO R 212 REMARK 465 LYS R 213 REMARK 465 ILE R 214 REMARK 465 SER R 215 REMARK 465 PHE R 216 REMARK 465 ASP R 217 REMARK 465 PRO R 218 REMARK 465 ILE R 219 REMARK 465 PRO R 220 REMARK 465 ILE R 221 REMARK 465 HIS R 222 REMARK 465 TYR R 223 REMARK 465 CYS R 224 REMARK 465 ALA R 225 REMARK 465 PRO R 226 REMARK 465 ALA R 227 REMARK 465 GLY R 228 REMARK 465 TYR R 229 REMARK 465 ALA R 230 REMARK 465 ILE R 231 REMARK 465 LEU R 232 REMARK 465 LYS R 233 REMARK 465 CYS R 234 REMARK 465 ASN R 235 REMARK 465 ASP R 236 REMARK 465 LYS R 237 REMARK 465 LYS R 238 REMARK 465 PHE R 239 REMARK 465 ASN R 240 REMARK 465 GLY R 241 REMARK 465 THR R 242 REMARK 465 GLY R 243 REMARK 465 PRO R 244 REMARK 465 CYS R 245 REMARK 465 LYS R 246 REMARK 465 ASN R 247 REMARK 465 VAL R 248 REMARK 465 SER R 249 REMARK 465 THR R 250 REMARK 465 VAL R 251 REMARK 465 GLN R 252 REMARK 465 CYS R 253 REMARK 465 THR R 254 REMARK 465 HIS R 255 REMARK 465 GLY R 256 REMARK 465 ILE R 257 REMARK 465 LYS R 258 REMARK 465 PRO R 259 REMARK 465 VAL R 260 REMARK 465 VAL R 261 REMARK 465 SER R 262 REMARK 465 THR R 263 REMARK 465 GLN R 264 REMARK 465 LEU R 265 REMARK 465 LEU R 266 REMARK 465 LEU R 267 REMARK 465 ASN R 268 REMARK 465 GLY R 269 REMARK 465 SER R 270 REMARK 465 LEU R 271 REMARK 465 ALA R 272 REMARK 465 GLU R 273 REMARK 465 GLU R 274 REMARK 465 GLU R 275 REMARK 465 ILE R 276 REMARK 465 ILE R 277 REMARK 465 ILE R 278 REMARK 465 ARG R 279 REMARK 465 SER R 280 REMARK 465 GLU R 281 REMARK 465 ASN R 282 REMARK 465 LEU R 283 REMARK 465 THR R 284 REMARK 465 ASN R 285 REMARK 465 ASN R 286 REMARK 465 ALA R 287 REMARK 465 LYS R 288 REMARK 465 ASN R 289 REMARK 465 ILE R 290 REMARK 465 ILE R 291 REMARK 465 VAL R 292 REMARK 465 HIS R 293 REMARK 465 LEU R 294 REMARK 465 ASN R 295 REMARK 465 LYS R 296 REMARK 465 SER R 297 REMARK 465 VAL R 298 REMARK 465 SER R 299 REMARK 465 ILE R 300 REMARK 465 SER R 301 REMARK 465 CYS R 302 REMARK 465 THR R 303 REMARK 465 ARG R 304 REMARK 465 PRO R 305 REMARK 465 SER R 306 REMARK 465 ASN R 307 REMARK 465 ASN R 308 REMARK 465 THR R 309 REMARK 465 ARG R 310 REMARK 465 THR R 311 REMARK 465 SER R 312 REMARK 465 ILE R 313 REMARK 465 ARG R 314 REMARK 465 ILE R 315 REMARK 465 GLY R 316 REMARK 465 PRO R 317 REMARK 465 GLY R 318 REMARK 465 GLN R 319 REMARK 465 MET R 320 REMARK 465 PHE R 321 REMARK 465 TYR R 322 REMARK 465 ARG R 323 REMARK 465 THR R 324 REMARK 465 GLY R 325 REMARK 465 ASP R 326 REMARK 465 ILE R 327 REMARK 465 ILE R 328 REMARK 465 GLY R 329 REMARK 465 ASP R 330 REMARK 465 ILE R 331 REMARK 465 ARG R 332 REMARK 465 LYS R 333 REMARK 465 ALA R 334 REMARK 465 TYR R 335 REMARK 465 CYS R 336 REMARK 465 GLU R 337 REMARK 465 LEU R 338 REMARK 465 ASN R 339 REMARK 465 GLY R 340 REMARK 465 THR R 341 REMARK 465 GLU R 342 REMARK 465 TRP R 343 REMARK 465 ASN R 344 REMARK 465 GLU R 345 REMARK 465 THR R 346 REMARK 465 LEU R 347 REMARK 465 ASN R 348 REMARK 465 LYS R 349 REMARK 465 VAL R 350 REMARK 465 THR R 351 REMARK 465 GLU R 352 REMARK 465 LYS R 353 REMARK 465 LEU R 354 REMARK 465 LYS R 355 REMARK 465 GLU R 356 REMARK 465 HIS R 357 REMARK 465 PHE R 358 REMARK 465 ASN R 359 REMARK 465 LYS R 360 REMARK 465 THR R 361 REMARK 465 ILE R 362 REMARK 465 VAL R 363 REMARK 465 PHE R 364 REMARK 465 GLN R 365 REMARK 465 PRO R 366 REMARK 465 PRO R 367 REMARK 465 SER R 368 REMARK 465 GLY R 369 REMARK 465 GLY R 370 REMARK 465 ASP R 371 REMARK 465 LEU R 372 REMARK 465 GLU R 373 REMARK 465 THR R 374 REMARK 465 THR R 375 REMARK 465 MET R 376 REMARK 465 HIS R 377 REMARK 465 HIS R 378 REMARK 465 PHE R 379 REMARK 465 ASN R 380 REMARK 465 CYS R 381 REMARK 465 ARG R 382 REMARK 465 GLY R 383 REMARK 465 GLU R 384 REMARK 465 PHE R 385 REMARK 465 PHE R 386 REMARK 465 TYR R 387 REMARK 465 CYS R 388 REMARK 465 ASN R 389 REMARK 465 THR R 390 REMARK 465 THR R 391 REMARK 465 LYS R 392 REMARK 465 LEU R 393 REMARK 465 PHE R 394 REMARK 465 ASN R 395 REMARK 465 THR R 396 REMARK 465 LYS R 397 REMARK 465 ASN R 398 REMARK 465 GLY R 399 REMARK 465 THR R 400 REMARK 465 ARG R 401 REMARK 465 GLU R 402 REMARK 465 GLU R 403 REMARK 465 PHE R 404 REMARK 465 ASN R 405 REMARK 465 GLY R 406 REMARK 465 THR R 407 REMARK 465 ILE R 408 REMARK 465 ILE R 409 REMARK 465 LEU R 410 REMARK 465 PRO R 411 REMARK 465 CYS R 412 REMARK 465 ARG R 413 REMARK 465 ILE R 414 REMARK 465 LYS R 415 REMARK 465 GLN R 416 REMARK 465 ILE R 417 REMARK 465 VAL R 418 REMARK 465 ASN R 419 REMARK 465 MET R 420 REMARK 465 TRP R 421 REMARK 465 GLN R 422 REMARK 465 GLY R 423 REMARK 465 VAL R 424 REMARK 465 GLY R 425 REMARK 465 GLN R 426 REMARK 465 ALA R 427 REMARK 465 MET R 428 REMARK 465 TYR R 429 REMARK 465 ALA R 430 REMARK 465 PRO R 431 REMARK 465 PRO R 432 REMARK 465 ILE R 433 REMARK 465 SER R 434 REMARK 465 GLY R 435 REMARK 465 ILE R 436 REMARK 465 ILE R 437 REMARK 465 ASN R 438 REMARK 465 CYS R 439 REMARK 465 THR R 440 REMARK 465 SER R 441 REMARK 465 ASN R 442 REMARK 465 ILE R 443 REMARK 465 THR R 444 REMARK 465 GLY R 445 REMARK 465 ILE R 446 REMARK 465 ILE R 447 REMARK 465 LEU R 448 REMARK 465 THR R 449 REMARK 465 ARG R 450 REMARK 465 ASP R 451 REMARK 465 GLY R 452 REMARK 465 GLY R 453 REMARK 465 ASN R 454 REMARK 465 GLY R 455 REMARK 465 ASN R 456 REMARK 465 THR R 457 REMARK 465 THR R 458 REMARK 465 ASP R 459 REMARK 465 GLU R 460 REMARK 465 THR R 461 REMARK 465 PHE R 462 REMARK 465 ARG R 463 REMARK 465 PRO R 464 REMARK 465 GLY R 465 REMARK 465 GLY R 466 REMARK 465 GLY R 467 REMARK 465 ASN R 468 REMARK 465 ILE R 469 REMARK 465 LYS R 470 REMARK 465 ASP R 471 REMARK 465 ASN R 472 REMARK 465 TRP R 473 REMARK 465 ARG R 474 REMARK 465 SER R 475 REMARK 465 GLU R 476 REMARK 465 LEU R 477 REMARK 465 TYR R 478 REMARK 465 LYS R 479 REMARK 465 TYR R 480 REMARK 465 LYS R 481 REMARK 465 VAL R 482 REMARK 465 VAL R 483 REMARK 465 GLN R 484 REMARK 465 ILE R 485 REMARK 465 GLU R 486 REMARK 465 PRO R 487 REMARK 465 LEU R 488 REMARK 465 GLY R 489 REMARK 465 ILE R 490 REMARK 465 ALA R 491 REMARK 465 PRO R 492 REMARK 465 THR R 493 REMARK 465 ARG R 494 REMARK 465 CYS R 495 REMARK 465 LYS R 496 REMARK 465 ARG R 497 REMARK 465 ARG R 498 REMARK 465 VAL R 499 REMARK 465 VAL R 500 REMARK 465 ASP R 501 REMARK 465 GLY R 502 REMARK 465 GLY R 503 REMARK 465 GLY R 504 REMARK 465 GLY R 505 REMARK 465 SER R 506 REMARK 465 GLY R 507 REMARK 465 GLY R 508 REMARK 465 GLY R 509 REMARK 465 GLY R 510 REMARK 465 SER R 511 REMARK 465 ALA R 512 REMARK 465 VAL R 513 REMARK 465 GLY R 514 REMARK 465 ILE R 515 REMARK 465 GLY R 516 REMARK 465 ALA R 517 REMARK 465 MET R 518 REMARK 465 ILE R 519 REMARK 465 PHE R 520 REMARK 465 LEU R 558 REMARK 465 SER R 559 REMARK 465 GLY R 560 REMARK 465 ASN R 561 REMARK 465 PRO R 562 REMARK 465 ASP R 563 REMARK 465 TRP R 564 REMARK 465 LEU R 565 REMARK 465 PRO R 566 REMARK 465 ASP R 567 REMARK 465 MET R 568 REMARK 465 ASP R 664 REMARK 465 ASN S 30 REMARK 465 LEU S 31 REMARK 465 TRP S 32 REMARK 465 VAL S 33 REMARK 465 THR S 34 REMARK 465 VAL S 35 REMARK 465 TYR S 36 REMARK 465 TYR S 37 REMARK 465 GLY S 38 REMARK 465 VAL S 39 REMARK 465 PRO S 40 REMARK 465 VAL S 41 REMARK 465 TRP S 42 REMARK 465 ARG S 43 REMARK 465 ASP S 44 REMARK 465 ALA S 45 REMARK 465 ASP S 46 REMARK 465 THR S 47 REMARK 465 THR S 48 REMARK 465 LEU S 49 REMARK 465 PHE S 50 REMARK 465 CYS S 51 REMARK 465 ALA S 52 REMARK 465 SER S 53 REMARK 465 ASP S 54 REMARK 465 ALA S 55 REMARK 465 LYS S 56 REMARK 465 ALA S 57 REMARK 465 HIS S 58 REMARK 465 VAL S 59 REMARK 465 PRO S 60 REMARK 465 GLU S 61 REMARK 465 ALA S 62 REMARK 465 HIS S 63 REMARK 465 ASN S 64 REMARK 465 VAL S 65 REMARK 465 TRP S 66 REMARK 465 ALA S 67 REMARK 465 THR S 68 REMARK 465 HIS S 69 REMARK 465 ALA S 70 REMARK 465 CYS S 71 REMARK 465 VAL S 72 REMARK 465 PRO S 73 REMARK 465 THR S 74 REMARK 465 ASP S 75 REMARK 465 PRO S 76 REMARK 465 ASN S 77 REMARK 465 PRO S 78 REMARK 465 GLN S 79 REMARK 465 GLU S 80 REMARK 465 ILE S 81 REMARK 465 PRO S 82 REMARK 465 LEU S 83 REMARK 465 GLU S 84 REMARK 465 ASN S 85 REMARK 465 VAL S 86 REMARK 465 THR S 87 REMARK 465 GLU S 88 REMARK 465 ASN S 89 REMARK 465 PHE S 90 REMARK 465 ASN S 91 REMARK 465 MET S 92 REMARK 465 TRP S 93 REMARK 465 LYS S 94 REMARK 465 ASN S 95 REMARK 465 ASN S 96 REMARK 465 MET S 97 REMARK 465 VAL S 98 REMARK 465 GLU S 99 REMARK 465 GLN S 100 REMARK 465 MET S 101 REMARK 465 GLN S 102 REMARK 465 GLU S 103 REMARK 465 ASP S 104 REMARK 465 VAL S 105 REMARK 465 ILE S 106 REMARK 465 SER S 107 REMARK 465 LEU S 108 REMARK 465 TRP S 109 REMARK 465 ASP S 110 REMARK 465 GLN S 111 REMARK 465 SER S 112 REMARK 465 LEU S 113 REMARK 465 LYS S 114 REMARK 465 PRO S 115 REMARK 465 CYS S 116 REMARK 465 VAL S 117 REMARK 465 LYS S 118 REMARK 465 LEU S 119 REMARK 465 THR S 120 REMARK 465 PRO S 121 REMARK 465 LEU S 122 REMARK 465 CYS S 123 REMARK 465 VAL S 124 REMARK 465 THR S 125 REMARK 465 LEU S 126 REMARK 465 ASN S 127 REMARK 465 CYS S 128 REMARK 465 THR S 129 REMARK 465 LYS S 130 REMARK 465 ALA S 131 REMARK 465 ASN S 132 REMARK 465 LEU S 133 REMARK 465 THR S 134 REMARK 465 HIS S 135 REMARK 465 ASN S 136 REMARK 465 THR S 137 REMARK 465 THR S 138 REMARK 465 ASN S 139 REMARK 465 ASP S 140 REMARK 465 LYS S 141 REMARK 465 ASN S 142 REMARK 465 GLY S 143 REMARK 465 THR S 144 REMARK 465 GLY S 145 REMARK 465 ASN S 146 REMARK 465 ILE S 147 REMARK 465 THR S 148 REMARK 465 ASP S 149 REMARK 465 GLU S 150 REMARK 465 VAL S 151 REMARK 465 LYS S 152 REMARK 465 ILE S 153 REMARK 465 GLY S 154 REMARK 465 ASN S 155 REMARK 465 ILE S 156 REMARK 465 THR S 157 REMARK 465 ASP S 158 REMARK 465 GLU S 159 REMARK 465 VAL S 160 REMARK 465 LYS S 161 REMARK 465 ASN S 162 REMARK 465 CYS S 163 REMARK 465 THR S 164 REMARK 465 PHE S 165 REMARK 465 ASN S 166 REMARK 465 MET S 167 REMARK 465 THR S 168 REMARK 465 THR S 169 REMARK 465 GLU S 170 REMARK 465 ILE S 171 REMARK 465 ARG S 172 REMARK 465 ASP S 173 REMARK 465 LYS S 174 REMARK 465 GLN S 175 REMARK 465 GLN S 176 REMARK 465 LYS S 177 REMARK 465 VAL S 178 REMARK 465 HIS S 179 REMARK 465 ALA S 180 REMARK 465 LEU S 181 REMARK 465 PHE S 182 REMARK 465 TYR S 183 REMARK 465 ALA S 184 REMARK 465 LEU S 185 REMARK 465 ASP S 186 REMARK 465 ILE S 187 REMARK 465 VAL S 188 REMARK 465 GLN S 189 REMARK 465 MET S 190 REMARK 465 LYS S 191 REMARK 465 GLU S 192 REMARK 465 ASN S 193 REMARK 465 GLY S 194 REMARK 465 SER S 195 REMARK 465 GLU S 196 REMARK 465 TYR S 197 REMARK 465 ARG S 198 REMARK 465 LEU S 199 REMARK 465 ILE S 200 REMARK 465 SER S 201 REMARK 465 CYS S 202 REMARK 465 ASN S 203 REMARK 465 THR S 204 REMARK 465 SER S 205 REMARK 465 VAL S 206 REMARK 465 ILE S 207 REMARK 465 LYS S 208 REMARK 465 GLN S 209 REMARK 465 ALA S 210 REMARK 465 CYS S 211 REMARK 465 PRO S 212 REMARK 465 LYS S 213 REMARK 465 ILE S 214 REMARK 465 SER S 215 REMARK 465 PHE S 216 REMARK 465 ASP S 217 REMARK 465 PRO S 218 REMARK 465 ILE S 219 REMARK 465 PRO S 220 REMARK 465 ILE S 221 REMARK 465 HIS S 222 REMARK 465 TYR S 223 REMARK 465 CYS S 224 REMARK 465 ALA S 225 REMARK 465 PRO S 226 REMARK 465 ALA S 227 REMARK 465 GLY S 228 REMARK 465 TYR S 229 REMARK 465 ALA S 230 REMARK 465 ILE S 231 REMARK 465 LEU S 232 REMARK 465 LYS S 233 REMARK 465 CYS S 234 REMARK 465 ASN S 235 REMARK 465 ASP S 236 REMARK 465 LYS S 237 REMARK 465 LYS S 238 REMARK 465 PHE S 239 REMARK 465 ASN S 240 REMARK 465 GLY S 241 REMARK 465 THR S 242 REMARK 465 GLY S 243 REMARK 465 PRO S 244 REMARK 465 CYS S 245 REMARK 465 LYS S 246 REMARK 465 ASN S 247 REMARK 465 VAL S 248 REMARK 465 SER S 249 REMARK 465 THR S 250 REMARK 465 VAL S 251 REMARK 465 GLN S 252 REMARK 465 CYS S 253 REMARK 465 THR S 254 REMARK 465 HIS S 255 REMARK 465 GLY S 256 REMARK 465 ILE S 257 REMARK 465 LYS S 258 REMARK 465 PRO S 259 REMARK 465 VAL S 260 REMARK 465 VAL S 261 REMARK 465 SER S 262 REMARK 465 THR S 263 REMARK 465 GLN S 264 REMARK 465 LEU S 265 REMARK 465 LEU S 266 REMARK 465 LEU S 267 REMARK 465 ASN S 268 REMARK 465 GLY S 269 REMARK 465 SER S 270 REMARK 465 LEU S 271 REMARK 465 ALA S 272 REMARK 465 GLU S 273 REMARK 465 GLU S 274 REMARK 465 GLU S 275 REMARK 465 ILE S 276 REMARK 465 ILE S 277 REMARK 465 ILE S 278 REMARK 465 ARG S 279 REMARK 465 SER S 280 REMARK 465 GLU S 281 REMARK 465 ASN S 282 REMARK 465 LEU S 283 REMARK 465 THR S 284 REMARK 465 ASN S 285 REMARK 465 ASN S 286 REMARK 465 ALA S 287 REMARK 465 LYS S 288 REMARK 465 ASN S 289 REMARK 465 ILE S 290 REMARK 465 ILE S 291 REMARK 465 VAL S 292 REMARK 465 HIS S 293 REMARK 465 LEU S 294 REMARK 465 ASN S 295 REMARK 465 LYS S 296 REMARK 465 SER S 297 REMARK 465 VAL S 298 REMARK 465 SER S 299 REMARK 465 ILE S 300 REMARK 465 SER S 301 REMARK 465 CYS S 302 REMARK 465 THR S 303 REMARK 465 ARG S 304 REMARK 465 PRO S 305 REMARK 465 SER S 306 REMARK 465 ASN S 307 REMARK 465 ASN S 308 REMARK 465 THR S 309 REMARK 465 ARG S 310 REMARK 465 THR S 311 REMARK 465 SER S 312 REMARK 465 ILE S 313 REMARK 465 ARG S 314 REMARK 465 ILE S 315 REMARK 465 GLY S 316 REMARK 465 PRO S 317 REMARK 465 GLY S 318 REMARK 465 GLN S 319 REMARK 465 MET S 320 REMARK 465 PHE S 321 REMARK 465 TYR S 322 REMARK 465 ARG S 323 REMARK 465 THR S 324 REMARK 465 GLY S 325 REMARK 465 ASP S 326 REMARK 465 ILE S 327 REMARK 465 ILE S 328 REMARK 465 GLY S 329 REMARK 465 ASP S 330 REMARK 465 ILE S 331 REMARK 465 ARG S 332 REMARK 465 LYS S 333 REMARK 465 ALA S 334 REMARK 465 TYR S 335 REMARK 465 CYS S 336 REMARK 465 GLU S 337 REMARK 465 LEU S 338 REMARK 465 ASN S 339 REMARK 465 GLY S 340 REMARK 465 THR S 341 REMARK 465 GLU S 342 REMARK 465 TRP S 343 REMARK 465 ASN S 344 REMARK 465 GLU S 345 REMARK 465 THR S 346 REMARK 465 LEU S 347 REMARK 465 ASN S 348 REMARK 465 LYS S 349 REMARK 465 VAL S 350 REMARK 465 THR S 351 REMARK 465 GLU S 352 REMARK 465 LYS S 353 REMARK 465 LEU S 354 REMARK 465 LYS S 355 REMARK 465 GLU S 356 REMARK 465 HIS S 357 REMARK 465 PHE S 358 REMARK 465 ASN S 359 REMARK 465 LYS S 360 REMARK 465 THR S 361 REMARK 465 ILE S 362 REMARK 465 VAL S 363 REMARK 465 PHE S 364 REMARK 465 GLN S 365 REMARK 465 PRO S 366 REMARK 465 PRO S 367 REMARK 465 SER S 368 REMARK 465 GLY S 369 REMARK 465 GLY S 370 REMARK 465 ASP S 371 REMARK 465 LEU S 372 REMARK 465 GLU S 373 REMARK 465 THR S 374 REMARK 465 THR S 375 REMARK 465 MET S 376 REMARK 465 HIS S 377 REMARK 465 HIS S 378 REMARK 465 PHE S 379 REMARK 465 ASN S 380 REMARK 465 CYS S 381 REMARK 465 ARG S 382 REMARK 465 GLY S 383 REMARK 465 GLU S 384 REMARK 465 PHE S 385 REMARK 465 PHE S 386 REMARK 465 TYR S 387 REMARK 465 CYS S 388 REMARK 465 ASN S 389 REMARK 465 THR S 390 REMARK 465 THR S 391 REMARK 465 LYS S 392 REMARK 465 LEU S 393 REMARK 465 PHE S 394 REMARK 465 ASN S 395 REMARK 465 THR S 396 REMARK 465 LYS S 397 REMARK 465 ASN S 398 REMARK 465 GLY S 399 REMARK 465 THR S 400 REMARK 465 ARG S 401 REMARK 465 GLU S 402 REMARK 465 GLU S 403 REMARK 465 PHE S 404 REMARK 465 ASN S 405 REMARK 465 GLY S 406 REMARK 465 THR S 407 REMARK 465 ILE S 408 REMARK 465 ILE S 409 REMARK 465 LEU S 410 REMARK 465 PRO S 411 REMARK 465 CYS S 412 REMARK 465 ARG S 413 REMARK 465 ILE S 414 REMARK 465 LYS S 415 REMARK 465 GLN S 416 REMARK 465 ILE S 417 REMARK 465 VAL S 418 REMARK 465 ASN S 419 REMARK 465 MET S 420 REMARK 465 TRP S 421 REMARK 465 GLN S 422 REMARK 465 GLY S 423 REMARK 465 VAL S 424 REMARK 465 GLY S 425 REMARK 465 GLN S 426 REMARK 465 ALA S 427 REMARK 465 MET S 428 REMARK 465 TYR S 429 REMARK 465 ALA S 430 REMARK 465 PRO S 431 REMARK 465 PRO S 432 REMARK 465 ILE S 433 REMARK 465 SER S 434 REMARK 465 GLY S 435 REMARK 465 ILE S 436 REMARK 465 ILE S 437 REMARK 465 ASN S 438 REMARK 465 CYS S 439 REMARK 465 THR S 440 REMARK 465 SER S 441 REMARK 465 ASN S 442 REMARK 465 ILE S 443 REMARK 465 THR S 444 REMARK 465 GLY S 445 REMARK 465 ILE S 446 REMARK 465 ILE S 447 REMARK 465 LEU S 448 REMARK 465 THR S 449 REMARK 465 ARG S 450 REMARK 465 ASP S 451 REMARK 465 GLY S 452 REMARK 465 GLY S 453 REMARK 465 ASN S 454 REMARK 465 GLY S 455 REMARK 465 ASN S 456 REMARK 465 THR S 457 REMARK 465 THR S 458 REMARK 465 ASP S 459 REMARK 465 GLU S 460 REMARK 465 THR S 461 REMARK 465 PHE S 462 REMARK 465 ARG S 463 REMARK 465 PRO S 464 REMARK 465 GLY S 465 REMARK 465 GLY S 466 REMARK 465 GLY S 467 REMARK 465 ASN S 468 REMARK 465 ILE S 469 REMARK 465 LYS S 470 REMARK 465 ASP S 471 REMARK 465 ASN S 472 REMARK 465 TRP S 473 REMARK 465 ARG S 474 REMARK 465 SER S 475 REMARK 465 GLU S 476 REMARK 465 LEU S 477 REMARK 465 TYR S 478 REMARK 465 LYS S 479 REMARK 465 TYR S 480 REMARK 465 LYS S 481 REMARK 465 VAL S 482 REMARK 465 VAL S 483 REMARK 465 GLN S 484 REMARK 465 ILE S 485 REMARK 465 GLU S 486 REMARK 465 PRO S 487 REMARK 465 LEU S 488 REMARK 465 GLY S 489 REMARK 465 ILE S 490 REMARK 465 ALA S 491 REMARK 465 PRO S 492 REMARK 465 THR S 493 REMARK 465 ARG S 494 REMARK 465 CYS S 495 REMARK 465 LYS S 496 REMARK 465 ARG S 497 REMARK 465 ARG S 498 REMARK 465 VAL S 499 REMARK 465 VAL S 500 REMARK 465 ASP S 501 REMARK 465 GLY S 502 REMARK 465 GLY S 503 REMARK 465 GLY S 504 REMARK 465 GLY S 505 REMARK 465 SER S 506 REMARK 465 GLY S 507 REMARK 465 GLY S 508 REMARK 465 GLY S 509 REMARK 465 GLY S 510 REMARK 465 SER S 511 REMARK 465 ALA S 512 REMARK 465 VAL S 513 REMARK 465 GLY S 514 REMARK 465 ILE S 515 REMARK 465 GLY S 516 REMARK 465 ALA S 517 REMARK 465 MET S 518 REMARK 465 ILE S 519 REMARK 465 PHE S 520 REMARK 465 LEU S 558 REMARK 465 SER S 559 REMARK 465 GLY S 560 REMARK 465 ASN S 561 REMARK 465 PRO S 562 REMARK 465 ASP S 563 REMARK 465 TRP S 564 REMARK 465 LEU S 565 REMARK 465 PRO S 566 REMARK 465 ASP S 567 REMARK 465 MET S 568 REMARK 465 ASP S 664 REMARK 465 ASN T 30 REMARK 465 LEU T 31 REMARK 465 TRP T 32 REMARK 465 VAL T 33 REMARK 465 THR T 34 REMARK 465 VAL T 35 REMARK 465 TYR T 36 REMARK 465 TYR T 37 REMARK 465 GLY T 38 REMARK 465 VAL T 39 REMARK 465 PRO T 40 REMARK 465 VAL T 41 REMARK 465 TRP T 42 REMARK 465 ARG T 43 REMARK 465 ASP T 44 REMARK 465 ALA T 45 REMARK 465 ASP T 46 REMARK 465 THR T 47 REMARK 465 THR T 48 REMARK 465 LEU T 49 REMARK 465 PHE T 50 REMARK 465 CYS T 51 REMARK 465 ALA T 52 REMARK 465 SER T 53 REMARK 465 ASP T 54 REMARK 465 ALA T 55 REMARK 465 LYS T 56 REMARK 465 ALA T 57 REMARK 465 HIS T 58 REMARK 465 VAL T 59 REMARK 465 PRO T 60 REMARK 465 GLU T 61 REMARK 465 ALA T 62 REMARK 465 HIS T 63 REMARK 465 ASN T 64 REMARK 465 VAL T 65 REMARK 465 TRP T 66 REMARK 465 ALA T 67 REMARK 465 THR T 68 REMARK 465 HIS T 69 REMARK 465 ALA T 70 REMARK 465 CYS T 71 REMARK 465 VAL T 72 REMARK 465 PRO T 73 REMARK 465 THR T 74 REMARK 465 ASP T 75 REMARK 465 PRO T 76 REMARK 465 ASN T 77 REMARK 465 PRO T 78 REMARK 465 GLN T 79 REMARK 465 GLU T 80 REMARK 465 ILE T 81 REMARK 465 PRO T 82 REMARK 465 LEU T 83 REMARK 465 GLU T 84 REMARK 465 ASN T 85 REMARK 465 VAL T 86 REMARK 465 THR T 87 REMARK 465 GLU T 88 REMARK 465 ASN T 89 REMARK 465 PHE T 90 REMARK 465 ASN T 91 REMARK 465 MET T 92 REMARK 465 TRP T 93 REMARK 465 LYS T 94 REMARK 465 ASN T 95 REMARK 465 ASN T 96 REMARK 465 MET T 97 REMARK 465 VAL T 98 REMARK 465 GLU T 99 REMARK 465 GLN T 100 REMARK 465 MET T 101 REMARK 465 GLN T 102 REMARK 465 GLU T 103 REMARK 465 ASP T 104 REMARK 465 VAL T 105 REMARK 465 ILE T 106 REMARK 465 SER T 107 REMARK 465 LEU T 108 REMARK 465 TRP T 109 REMARK 465 ASP T 110 REMARK 465 GLN T 111 REMARK 465 SER T 112 REMARK 465 LEU T 113 REMARK 465 LYS T 114 REMARK 465 PRO T 115 REMARK 465 CYS T 116 REMARK 465 VAL T 117 REMARK 465 LYS T 118 REMARK 465 LEU T 119 REMARK 465 THR T 120 REMARK 465 PRO T 121 REMARK 465 LEU T 122 REMARK 465 CYS T 123 REMARK 465 VAL T 124 REMARK 465 THR T 125 REMARK 465 LEU T 126 REMARK 465 ASN T 127 REMARK 465 CYS T 128 REMARK 465 THR T 129 REMARK 465 LYS T 130 REMARK 465 ALA T 131 REMARK 465 ASN T 132 REMARK 465 LEU T 133 REMARK 465 THR T 134 REMARK 465 HIS T 135 REMARK 465 ASN T 136 REMARK 465 THR T 137 REMARK 465 THR T 138 REMARK 465 ASN T 139 REMARK 465 ASP T 140 REMARK 465 LYS T 141 REMARK 465 ASN T 142 REMARK 465 GLY T 143 REMARK 465 THR T 144 REMARK 465 GLY T 145 REMARK 465 ASN T 146 REMARK 465 ILE T 147 REMARK 465 THR T 148 REMARK 465 ASP T 149 REMARK 465 GLU T 150 REMARK 465 VAL T 151 REMARK 465 LYS T 152 REMARK 465 ILE T 153 REMARK 465 GLY T 154 REMARK 465 ASN T 155 REMARK 465 ILE T 156 REMARK 465 THR T 157 REMARK 465 ASP T 158 REMARK 465 GLU T 159 REMARK 465 VAL T 160 REMARK 465 LYS T 161 REMARK 465 ASN T 162 REMARK 465 CYS T 163 REMARK 465 THR T 164 REMARK 465 PHE T 165 REMARK 465 ASN T 166 REMARK 465 MET T 167 REMARK 465 THR T 168 REMARK 465 THR T 169 REMARK 465 GLU T 170 REMARK 465 ILE T 171 REMARK 465 ARG T 172 REMARK 465 ASP T 173 REMARK 465 LYS T 174 REMARK 465 GLN T 175 REMARK 465 GLN T 176 REMARK 465 LYS T 177 REMARK 465 VAL T 178 REMARK 465 HIS T 179 REMARK 465 ALA T 180 REMARK 465 LEU T 181 REMARK 465 PHE T 182 REMARK 465 TYR T 183 REMARK 465 ALA T 184 REMARK 465 LEU T 185 REMARK 465 ASP T 186 REMARK 465 ILE T 187 REMARK 465 VAL T 188 REMARK 465 GLN T 189 REMARK 465 MET T 190 REMARK 465 LYS T 191 REMARK 465 GLU T 192 REMARK 465 ASN T 193 REMARK 465 GLY T 194 REMARK 465 SER T 195 REMARK 465 GLU T 196 REMARK 465 TYR T 197 REMARK 465 ARG T 198 REMARK 465 LEU T 199 REMARK 465 ILE T 200 REMARK 465 SER T 201 REMARK 465 CYS T 202 REMARK 465 ASN T 203 REMARK 465 THR T 204 REMARK 465 SER T 205 REMARK 465 VAL T 206 REMARK 465 ILE T 207 REMARK 465 LYS T 208 REMARK 465 GLN T 209 REMARK 465 ALA T 210 REMARK 465 CYS T 211 REMARK 465 PRO T 212 REMARK 465 LYS T 213 REMARK 465 ILE T 214 REMARK 465 SER T 215 REMARK 465 PHE T 216 REMARK 465 ASP T 217 REMARK 465 PRO T 218 REMARK 465 ILE T 219 REMARK 465 PRO T 220 REMARK 465 ILE T 221 REMARK 465 HIS T 222 REMARK 465 TYR T 223 REMARK 465 CYS T 224 REMARK 465 ALA T 225 REMARK 465 PRO T 226 REMARK 465 ALA T 227 REMARK 465 GLY T 228 REMARK 465 TYR T 229 REMARK 465 ALA T 230 REMARK 465 ILE T 231 REMARK 465 LEU T 232 REMARK 465 LYS T 233 REMARK 465 CYS T 234 REMARK 465 ASN T 235 REMARK 465 ASP T 236 REMARK 465 LYS T 237 REMARK 465 LYS T 238 REMARK 465 PHE T 239 REMARK 465 ASN T 240 REMARK 465 GLY T 241 REMARK 465 THR T 242 REMARK 465 GLY T 243 REMARK 465 PRO T 244 REMARK 465 CYS T 245 REMARK 465 LYS T 246 REMARK 465 ASN T 247 REMARK 465 VAL T 248 REMARK 465 SER T 249 REMARK 465 THR T 250 REMARK 465 VAL T 251 REMARK 465 GLN T 252 REMARK 465 CYS T 253 REMARK 465 THR T 254 REMARK 465 HIS T 255 REMARK 465 GLY T 256 REMARK 465 ILE T 257 REMARK 465 LYS T 258 REMARK 465 PRO T 259 REMARK 465 VAL T 260 REMARK 465 VAL T 261 REMARK 465 SER T 262 REMARK 465 THR T 263 REMARK 465 GLN T 264 REMARK 465 LEU T 265 REMARK 465 LEU T 266 REMARK 465 LEU T 267 REMARK 465 ASN T 268 REMARK 465 GLY T 269 REMARK 465 SER T 270 REMARK 465 LEU T 271 REMARK 465 ALA T 272 REMARK 465 GLU T 273 REMARK 465 GLU T 274 REMARK 465 GLU T 275 REMARK 465 ILE T 276 REMARK 465 ILE T 277 REMARK 465 ILE T 278 REMARK 465 ARG T 279 REMARK 465 SER T 280 REMARK 465 GLU T 281 REMARK 465 ASN T 282 REMARK 465 LEU T 283 REMARK 465 THR T 284 REMARK 465 ASN T 285 REMARK 465 ASN T 286 REMARK 465 ALA T 287 REMARK 465 LYS T 288 REMARK 465 ASN T 289 REMARK 465 ILE T 290 REMARK 465 ILE T 291 REMARK 465 VAL T 292 REMARK 465 HIS T 293 REMARK 465 LEU T 294 REMARK 465 ASN T 295 REMARK 465 LYS T 296 REMARK 465 SER T 297 REMARK 465 VAL T 298 REMARK 465 SER T 299 REMARK 465 ILE T 300 REMARK 465 SER T 301 REMARK 465 CYS T 302 REMARK 465 THR T 303 REMARK 465 ARG T 304 REMARK 465 PRO T 305 REMARK 465 SER T 306 REMARK 465 ASN T 307 REMARK 465 ASN T 308 REMARK 465 THR T 309 REMARK 465 ARG T 310 REMARK 465 THR T 311 REMARK 465 SER T 312 REMARK 465 ILE T 313 REMARK 465 ARG T 314 REMARK 465 ILE T 315 REMARK 465 GLY T 316 REMARK 465 PRO T 317 REMARK 465 GLY T 318 REMARK 465 GLN T 319 REMARK 465 MET T 320 REMARK 465 PHE T 321 REMARK 465 TYR T 322 REMARK 465 ARG T 323 REMARK 465 THR T 324 REMARK 465 GLY T 325 REMARK 465 ASP T 326 REMARK 465 ILE T 327 REMARK 465 ILE T 328 REMARK 465 GLY T 329 REMARK 465 ASP T 330 REMARK 465 ILE T 331 REMARK 465 ARG T 332 REMARK 465 LYS T 333 REMARK 465 ALA T 334 REMARK 465 TYR T 335 REMARK 465 CYS T 336 REMARK 465 GLU T 337 REMARK 465 LEU T 338 REMARK 465 ASN T 339 REMARK 465 GLY T 340 REMARK 465 THR T 341 REMARK 465 GLU T 342 REMARK 465 TRP T 343 REMARK 465 ASN T 344 REMARK 465 GLU T 345 REMARK 465 THR T 346 REMARK 465 LEU T 347 REMARK 465 ASN T 348 REMARK 465 LYS T 349 REMARK 465 VAL T 350 REMARK 465 THR T 351 REMARK 465 GLU T 352 REMARK 465 LYS T 353 REMARK 465 LEU T 354 REMARK 465 LYS T 355 REMARK 465 GLU T 356 REMARK 465 HIS T 357 REMARK 465 PHE T 358 REMARK 465 ASN T 359 REMARK 465 LYS T 360 REMARK 465 THR T 361 REMARK 465 ILE T 362 REMARK 465 VAL T 363 REMARK 465 PHE T 364 REMARK 465 GLN T 365 REMARK 465 PRO T 366 REMARK 465 PRO T 367 REMARK 465 SER T 368 REMARK 465 GLY T 369 REMARK 465 GLY T 370 REMARK 465 ASP T 371 REMARK 465 LEU T 372 REMARK 465 GLU T 373 REMARK 465 THR T 374 REMARK 465 THR T 375 REMARK 465 MET T 376 REMARK 465 HIS T 377 REMARK 465 HIS T 378 REMARK 465 PHE T 379 REMARK 465 ASN T 380 REMARK 465 CYS T 381 REMARK 465 ARG T 382 REMARK 465 GLY T 383 REMARK 465 GLU T 384 REMARK 465 PHE T 385 REMARK 465 PHE T 386 REMARK 465 TYR T 387 REMARK 465 CYS T 388 REMARK 465 ASN T 389 REMARK 465 THR T 390 REMARK 465 THR T 391 REMARK 465 LYS T 392 REMARK 465 LEU T 393 REMARK 465 PHE T 394 REMARK 465 ASN T 395 REMARK 465 THR T 396 REMARK 465 LYS T 397 REMARK 465 ASN T 398 REMARK 465 GLY T 399 REMARK 465 THR T 400 REMARK 465 ARG T 401 REMARK 465 GLU T 402 REMARK 465 GLU T 403 REMARK 465 PHE T 404 REMARK 465 ASN T 405 REMARK 465 GLY T 406 REMARK 465 THR T 407 REMARK 465 ILE T 408 REMARK 465 ILE T 409 REMARK 465 LEU T 410 REMARK 465 PRO T 411 REMARK 465 CYS T 412 REMARK 465 ARG T 413 REMARK 465 ILE T 414 REMARK 465 LYS T 415 REMARK 465 GLN T 416 REMARK 465 ILE T 417 REMARK 465 VAL T 418 REMARK 465 ASN T 419 REMARK 465 MET T 420 REMARK 465 TRP T 421 REMARK 465 GLN T 422 REMARK 465 GLY T 423 REMARK 465 VAL T 424 REMARK 465 GLY T 425 REMARK 465 GLN T 426 REMARK 465 ALA T 427 REMARK 465 MET T 428 REMARK 465 TYR T 429 REMARK 465 ALA T 430 REMARK 465 PRO T 431 REMARK 465 PRO T 432 REMARK 465 ILE T 433 REMARK 465 SER T 434 REMARK 465 GLY T 435 REMARK 465 ILE T 436 REMARK 465 ILE T 437 REMARK 465 ASN T 438 REMARK 465 CYS T 439 REMARK 465 THR T 440 REMARK 465 SER T 441 REMARK 465 ASN T 442 REMARK 465 ILE T 443 REMARK 465 THR T 444 REMARK 465 GLY T 445 REMARK 465 ILE T 446 REMARK 465 ILE T 447 REMARK 465 LEU T 448 REMARK 465 THR T 449 REMARK 465 ARG T 450 REMARK 465 ASP T 451 REMARK 465 GLY T 452 REMARK 465 GLY T 453 REMARK 465 ASN T 454 REMARK 465 GLY T 455 REMARK 465 ASN T 456 REMARK 465 THR T 457 REMARK 465 THR T 458 REMARK 465 ASP T 459 REMARK 465 GLU T 460 REMARK 465 THR T 461 REMARK 465 PHE T 462 REMARK 465 ARG T 463 REMARK 465 PRO T 464 REMARK 465 GLY T 465 REMARK 465 GLY T 466 REMARK 465 GLY T 467 REMARK 465 ASN T 468 REMARK 465 ILE T 469 REMARK 465 LYS T 470 REMARK 465 ASP T 471 REMARK 465 ASN T 472 REMARK 465 TRP T 473 REMARK 465 ARG T 474 REMARK 465 SER T 475 REMARK 465 GLU T 476 REMARK 465 LEU T 477 REMARK 465 TYR T 478 REMARK 465 LYS T 479 REMARK 465 TYR T 480 REMARK 465 LYS T 481 REMARK 465 VAL T 482 REMARK 465 VAL T 483 REMARK 465 GLN T 484 REMARK 465 ILE T 485 REMARK 465 GLU T 486 REMARK 465 PRO T 487 REMARK 465 LEU T 488 REMARK 465 GLY T 489 REMARK 465 ILE T 490 REMARK 465 ALA T 491 REMARK 465 PRO T 492 REMARK 465 THR T 493 REMARK 465 ARG T 494 REMARK 465 CYS T 495 REMARK 465 LYS T 496 REMARK 465 ARG T 497 REMARK 465 ARG T 498 REMARK 465 VAL T 499 REMARK 465 VAL T 500 REMARK 465 ASP T 501 REMARK 465 GLY T 502 REMARK 465 GLY T 503 REMARK 465 GLY T 504 REMARK 465 GLY T 505 REMARK 465 SER T 506 REMARK 465 GLY T 507 REMARK 465 GLY T 508 REMARK 465 GLY T 509 REMARK 465 GLY T 510 REMARK 465 SER T 511 REMARK 465 ALA T 512 REMARK 465 VAL T 513 REMARK 465 GLY T 514 REMARK 465 ILE T 515 REMARK 465 GLY T 516 REMARK 465 ALA T 517 REMARK 465 MET T 518 REMARK 465 ILE T 519 REMARK 465 PHE T 520 REMARK 465 LEU T 558 REMARK 465 SER T 559 REMARK 465 GLY T 560 REMARK 465 ASN T 561 REMARK 465 PRO T 562 REMARK 465 ASP T 563 REMARK 465 TRP T 564 REMARK 465 LEU T 565 REMARK 465 PRO T 566 REMARK 465 ASP T 567 REMARK 465 MET T 568 REMARK 465 ASP T 664 REMARK 465 ALA X 58 REMARK 465 LYS X 59 REMARK 465 ALA X 60 REMARK 465 HIS X 61 REMARK 465 VAL X 62 REMARK 465 PRO X 63 REMARK 465 GLU X 64 REMARK 465 ALA X 65 REMARK 465 HIS X 66 REMARK 465 ASN X 67 REMARK 465 VAL X 68 REMARK 465 TRP X 69 REMARK 465 ALA X 70 REMARK 465 ASN X 138A REMARK 465 THR X 138B REMARK 465 THR X 138C REMARK 465 ASN X 138D REMARK 465 ASP X 138E REMARK 465 LYS X 138F REMARK 465 ASN X 138G REMARK 465 GLY X 138H REMARK 465 THR X 138I REMARK 465 GLY X 138J REMARK 465 ASN X 138K REMARK 465 ILE X 138L REMARK 465 THR X 138M REMARK 465 ASP X 138N REMARK 465 GLU X 138O REMARK 465 VAL X 138P REMARK 465 LYS X 138Q REMARK 465 LYS X 403 REMARK 465 ASN X 404 REMARK 465 GLY X 405 REMARK 465 THR X 406 REMARK 465 ARG X 407 REMARK 465 GLU X 408 REMARK 465 VAL X 505 REMARK 465 VAL X 506 REMARK 465 ASP X 507 REMARK 465 GLY X 508 REMARK 465 GLY X 509 REMARK 465 GLY X 510 REMARK 465 GLY X 511 REMARK 465 SER X 512 REMARK 465 GLY X 513 REMARK 465 GLY X 514 REMARK 465 GLY X 515 REMARK 465 GLY X 516 REMARK 465 SER X 517 REMARK 465 ALA X 518 REMARK 465 VAL X 519 REMARK 465 GLY X 520 REMARK 465 ILE X 521 REMARK 465 GLY X 522 REMARK 465 ALA X 523 REMARK 465 MET X 524 REMARK 465 ILE X 525 REMARK 465 PHE X 526 REMARK 465 GLY X 527 REMARK 465 PHE X 528 REMARK 465 LEU X 529 REMARK 465 GLY X 530 REMARK 465 ALA X 531 REMARK 465 ALA X 532 REMARK 465 GLY X 533 REMARK 465 SER X 534 REMARK 465 THR X 535 REMARK 465 MET X 536 REMARK 465 GLY X 537 REMARK 465 ALA X 538 REMARK 465 ALA X 539 REMARK 465 SER X 540 REMARK 465 ILE X 541 REMARK 465 THR X 542 REMARK 465 LEU X 543 REMARK 465 THR X 544 REMARK 465 VAL X 545 REMARK 465 GLN X 546 REMARK 465 ALA X 547 REMARK 465 ARG X 548 REMARK 465 GLN X 549 REMARK 465 LEU X 550 REMARK 465 LEU X 551 REMARK 465 SER X 552 REMARK 465 GLY X 553 REMARK 465 ASN X 554 REMARK 465 PRO X 555 REMARK 465 ASP X 556 REMARK 465 TRP X 557 REMARK 465 LEU X 558 REMARK 465 PRO X 559 REMARK 465 ASP X 560 REMARK 465 MET X 561 REMARK 465 THR X 562 REMARK 465 VAL X 563 REMARK 465 TRP X 564 REMARK 465 GLY X 565 REMARK 465 ILE X 566 REMARK 465 LYS X 567 REMARK 465 GLN X 568 REMARK 465 LEU X 569 REMARK 465 GLN X 570 REMARK 465 ALA X 571 REMARK 465 ARG X 572 REMARK 465 VAL X 573 REMARK 465 LEU X 574 REMARK 465 ALA X 575 REMARK 465 VAL X 576 REMARK 465 GLU X 577 REMARK 465 ARG X 578 REMARK 465 TYR X 579 REMARK 465 LEU X 580 REMARK 465 LYS X 581 REMARK 465 ASP X 582 REMARK 465 GLN X 583 REMARK 465 LYS X 584 REMARK 465 PHE X 585 REMARK 465 LEU X 586 REMARK 465 GLY X 587 REMARK 465 LEU X 588 REMARK 465 TRP X 589 REMARK 465 GLY X 590 REMARK 465 CYS X 591 REMARK 465 SER X 592 REMARK 465 GLY X 593 REMARK 465 LYS X 594 REMARK 465 ILE X 595 REMARK 465 ILE X 596 REMARK 465 CYS X 597 REMARK 465 CYS X 598 REMARK 465 THR X 599 REMARK 465 ASN X 600 REMARK 465 VAL X 601 REMARK 465 PRO X 602 REMARK 465 TRP X 603 REMARK 465 ASN X 604 REMARK 465 SER X 605 REMARK 465 THR X 606 REMARK 465 TRP X 607 REMARK 465 SER X 608 REMARK 465 ASN X 609 REMARK 465 LYS X 610 REMARK 465 SER X 611 REMARK 465 TYR X 612 REMARK 465 GLU X 613 REMARK 465 GLU X 614 REMARK 465 ILE X 615 REMARK 465 TRP X 616 REMARK 465 ASN X 617 REMARK 465 ASN X 618 REMARK 465 MET X 619 REMARK 465 THR X 620 REMARK 465 TRP X 621 REMARK 465 ILE X 622 REMARK 465 GLU X 623 REMARK 465 TRP X 624 REMARK 465 GLU X 625 REMARK 465 LYS X 626 REMARK 465 GLU X 627 REMARK 465 ILE X 628 REMARK 465 SER X 629 REMARK 465 ASN X 630 REMARK 465 TYR X 631 REMARK 465 THR X 632 REMARK 465 ASN X 633 REMARK 465 ARG X 634 REMARK 465 ILE X 635 REMARK 465 TYR X 636 REMARK 465 ASP X 637 REMARK 465 LEU X 638 REMARK 465 LEU X 639 REMARK 465 THR X 640 REMARK 465 GLU X 641 REMARK 465 SER X 642 REMARK 465 GLN X 643 REMARK 465 ASN X 644 REMARK 465 GLN X 645 REMARK 465 GLN X 646 REMARK 465 GLU X 647 REMARK 465 ARG X 648 REMARK 465 ASN X 649 REMARK 465 GLU X 650 REMARK 465 LYS X 651 REMARK 465 ASP X 652 REMARK 465 LEU X 653 REMARK 465 LEU X 654 REMARK 465 GLU X 655 REMARK 465 LEU X 656 REMARK 465 ASP X 657 REMARK 465 ALA Y 58 REMARK 465 LYS Y 59 REMARK 465 ALA Y 60 REMARK 465 HIS Y 61 REMARK 465 VAL Y 62 REMARK 465 PRO Y 63 REMARK 465 GLU Y 64 REMARK 465 ALA Y 65 REMARK 465 HIS Y 66 REMARK 465 ASN Y 67 REMARK 465 VAL Y 68 REMARK 465 TRP Y 69 REMARK 465 ALA Y 70 REMARK 465 ASN Y 138A REMARK 465 THR Y 138B REMARK 465 THR Y 138C REMARK 465 ASN Y 138D REMARK 465 ASP Y 138E REMARK 465 LYS Y 138F REMARK 465 ASN Y 138G REMARK 465 GLY Y 138H REMARK 465 THR Y 138I REMARK 465 GLY Y 138J REMARK 465 ASN Y 138K REMARK 465 ILE Y 138L REMARK 465 THR Y 138M REMARK 465 ASP Y 138N REMARK 465 GLU Y 138O REMARK 465 VAL Y 138P REMARK 465 LYS Y 138Q REMARK 465 LYS Y 403 REMARK 465 ASN Y 404 REMARK 465 GLY Y 405 REMARK 465 THR Y 406 REMARK 465 ARG Y 407 REMARK 465 GLU Y 408 REMARK 465 VAL Y 505 REMARK 465 VAL Y 506 REMARK 465 ASP Y 507 REMARK 465 GLY Y 508 REMARK 465 GLY Y 509 REMARK 465 GLY Y 510 REMARK 465 GLY Y 511 REMARK 465 SER Y 512 REMARK 465 GLY Y 513 REMARK 465 GLY Y 514 REMARK 465 GLY Y 515 REMARK 465 GLY Y 516 REMARK 465 SER Y 517 REMARK 465 ALA Y 518 REMARK 465 VAL Y 519 REMARK 465 GLY Y 520 REMARK 465 ILE Y 521 REMARK 465 GLY Y 522 REMARK 465 ALA Y 523 REMARK 465 MET Y 524 REMARK 465 ILE Y 525 REMARK 465 PHE Y 526 REMARK 465 GLY Y 527 REMARK 465 PHE Y 528 REMARK 465 LEU Y 529 REMARK 465 GLY Y 530 REMARK 465 ALA Y 531 REMARK 465 ALA Y 532 REMARK 465 GLY Y 533 REMARK 465 SER Y 534 REMARK 465 THR Y 535 REMARK 465 MET Y 536 REMARK 465 GLY Y 537 REMARK 465 ALA Y 538 REMARK 465 ALA Y 539 REMARK 465 SER Y 540 REMARK 465 ILE Y 541 REMARK 465 THR Y 542 REMARK 465 LEU Y 543 REMARK 465 THR Y 544 REMARK 465 VAL Y 545 REMARK 465 GLN Y 546 REMARK 465 ALA Y 547 REMARK 465 ARG Y 548 REMARK 465 GLN Y 549 REMARK 465 LEU Y 550 REMARK 465 LEU Y 551 REMARK 465 SER Y 552 REMARK 465 GLY Y 553 REMARK 465 ASN Y 554 REMARK 465 PRO Y 555 REMARK 465 ASP Y 556 REMARK 465 TRP Y 557 REMARK 465 LEU Y 558 REMARK 465 PRO Y 559 REMARK 465 ASP Y 560 REMARK 465 MET Y 561 REMARK 465 THR Y 562 REMARK 465 VAL Y 563 REMARK 465 TRP Y 564 REMARK 465 GLY Y 565 REMARK 465 ILE Y 566 REMARK 465 LYS Y 567 REMARK 465 GLN Y 568 REMARK 465 LEU Y 569 REMARK 465 GLN Y 570 REMARK 465 ALA Y 571 REMARK 465 ARG Y 572 REMARK 465 VAL Y 573 REMARK 465 LEU Y 574 REMARK 465 ALA Y 575 REMARK 465 VAL Y 576 REMARK 465 GLU Y 577 REMARK 465 ARG Y 578 REMARK 465 TYR Y 579 REMARK 465 LEU Y 580 REMARK 465 LYS Y 581 REMARK 465 ASP Y 582 REMARK 465 GLN Y 583 REMARK 465 LYS Y 584 REMARK 465 PHE Y 585 REMARK 465 LEU Y 586 REMARK 465 GLY Y 587 REMARK 465 LEU Y 588 REMARK 465 TRP Y 589 REMARK 465 GLY Y 590 REMARK 465 CYS Y 591 REMARK 465 SER Y 592 REMARK 465 GLY Y 593 REMARK 465 LYS Y 594 REMARK 465 ILE Y 595 REMARK 465 ILE Y 596 REMARK 465 CYS Y 597 REMARK 465 CYS Y 598 REMARK 465 THR Y 599 REMARK 465 ASN Y 600 REMARK 465 VAL Y 601 REMARK 465 PRO Y 602 REMARK 465 TRP Y 603 REMARK 465 ASN Y 604 REMARK 465 SER Y 605 REMARK 465 THR Y 606 REMARK 465 TRP Y 607 REMARK 465 SER Y 608 REMARK 465 ASN Y 609 REMARK 465 LYS Y 610 REMARK 465 SER Y 611 REMARK 465 TYR Y 612 REMARK 465 GLU Y 613 REMARK 465 GLU Y 614 REMARK 465 ILE Y 615 REMARK 465 TRP Y 616 REMARK 465 ASN Y 617 REMARK 465 ASN Y 618 REMARK 465 MET Y 619 REMARK 465 THR Y 620 REMARK 465 TRP Y 621 REMARK 465 ILE Y 622 REMARK 465 GLU Y 623 REMARK 465 TRP Y 624 REMARK 465 GLU Y 625 REMARK 465 LYS Y 626 REMARK 465 GLU Y 627 REMARK 465 ILE Y 628 REMARK 465 SER Y 629 REMARK 465 ASN Y 630 REMARK 465 TYR Y 631 REMARK 465 THR Y 632 REMARK 465 ASN Y 633 REMARK 465 ARG Y 634 REMARK 465 ILE Y 635 REMARK 465 TYR Y 636 REMARK 465 ASP Y 637 REMARK 465 LEU Y 638 REMARK 465 LEU Y 639 REMARK 465 THR Y 640 REMARK 465 GLU Y 641 REMARK 465 SER Y 642 REMARK 465 GLN Y 643 REMARK 465 ASN Y 644 REMARK 465 GLN Y 645 REMARK 465 GLN Y 646 REMARK 465 GLU Y 647 REMARK 465 ARG Y 648 REMARK 465 ASN Y 649 REMARK 465 GLU Y 650 REMARK 465 LYS Y 651 REMARK 465 ASP Y 652 REMARK 465 LEU Y 653 REMARK 465 LEU Y 654 REMARK 465 GLU Y 655 REMARK 465 LEU Y 656 REMARK 465 ASP Y 657 REMARK 465 ALA Z 58 REMARK 465 LYS Z 59 REMARK 465 ALA Z 60 REMARK 465 HIS Z 61 REMARK 465 VAL Z 62 REMARK 465 PRO Z 63 REMARK 465 GLU Z 64 REMARK 465 ALA Z 65 REMARK 465 HIS Z 66 REMARK 465 ASN Z 67 REMARK 465 VAL Z 68 REMARK 465 TRP Z 69 REMARK 465 ALA Z 70 REMARK 465 ASN Z 138A REMARK 465 THR Z 138B REMARK 465 THR Z 138C REMARK 465 ASN Z 138D REMARK 465 ASP Z 138E REMARK 465 LYS Z 138F REMARK 465 ASN Z 138G REMARK 465 GLY Z 138H REMARK 465 THR Z 138I REMARK 465 GLY Z 138J REMARK 465 ASN Z 138K REMARK 465 ILE Z 138L REMARK 465 THR Z 138M REMARK 465 ASP Z 138N REMARK 465 GLU Z 138O REMARK 465 VAL Z 138P REMARK 465 LYS Z 138Q REMARK 465 LYS Z 403 REMARK 465 ASN Z 404 REMARK 465 GLY Z 405 REMARK 465 THR Z 406 REMARK 465 ARG Z 407 REMARK 465 GLU Z 408 REMARK 465 VAL Z 505 REMARK 465 VAL Z 506 REMARK 465 ASP Z 507 REMARK 465 GLY Z 508 REMARK 465 GLY Z 509 REMARK 465 GLY Z 510 REMARK 465 GLY Z 511 REMARK 465 SER Z 512 REMARK 465 GLY Z 513 REMARK 465 GLY Z 514 REMARK 465 GLY Z 515 REMARK 465 GLY Z 516 REMARK 465 SER Z 517 REMARK 465 ALA Z 518 REMARK 465 VAL Z 519 REMARK 465 GLY Z 520 REMARK 465 ILE Z 521 REMARK 465 GLY Z 522 REMARK 465 ALA Z 523 REMARK 465 MET Z 524 REMARK 465 ILE Z 525 REMARK 465 PHE Z 526 REMARK 465 GLY Z 527 REMARK 465 PHE Z 528 REMARK 465 LEU Z 529 REMARK 465 GLY Z 530 REMARK 465 ALA Z 531 REMARK 465 ALA Z 532 REMARK 465 GLY Z 533 REMARK 465 SER Z 534 REMARK 465 THR Z 535 REMARK 465 MET Z 536 REMARK 465 GLY Z 537 REMARK 465 ALA Z 538 REMARK 465 ALA Z 539 REMARK 465 SER Z 540 REMARK 465 ILE Z 541 REMARK 465 THR Z 542 REMARK 465 LEU Z 543 REMARK 465 THR Z 544 REMARK 465 VAL Z 545 REMARK 465 GLN Z 546 REMARK 465 ALA Z 547 REMARK 465 ARG Z 548 REMARK 465 GLN Z 549 REMARK 465 LEU Z 550 REMARK 465 LEU Z 551 REMARK 465 SER Z 552 REMARK 465 GLY Z 553 REMARK 465 ASN Z 554 REMARK 465 PRO Z 555 REMARK 465 ASP Z 556 REMARK 465 TRP Z 557 REMARK 465 LEU Z 558 REMARK 465 PRO Z 559 REMARK 465 ASP Z 560 REMARK 465 MET Z 561 REMARK 465 THR Z 562 REMARK 465 VAL Z 563 REMARK 465 TRP Z 564 REMARK 465 GLY Z 565 REMARK 465 ILE Z 566 REMARK 465 LYS Z 567 REMARK 465 GLN Z 568 REMARK 465 LEU Z 569 REMARK 465 GLN Z 570 REMARK 465 ALA Z 571 REMARK 465 ARG Z 572 REMARK 465 VAL Z 573 REMARK 465 LEU Z 574 REMARK 465 ALA Z 575 REMARK 465 VAL Z 576 REMARK 465 GLU Z 577 REMARK 465 ARG Z 578 REMARK 465 TYR Z 579 REMARK 465 LEU Z 580 REMARK 465 LYS Z 581 REMARK 465 ASP Z 582 REMARK 465 GLN Z 583 REMARK 465 LYS Z 584 REMARK 465 PHE Z 585 REMARK 465 LEU Z 586 REMARK 465 GLY Z 587 REMARK 465 LEU Z 588 REMARK 465 TRP Z 589 REMARK 465 GLY Z 590 REMARK 465 CYS Z 591 REMARK 465 SER Z 592 REMARK 465 GLY Z 593 REMARK 465 LYS Z 594 REMARK 465 ILE Z 595 REMARK 465 ILE Z 596 REMARK 465 CYS Z 597 REMARK 465 CYS Z 598 REMARK 465 THR Z 599 REMARK 465 ASN Z 600 REMARK 465 VAL Z 601 REMARK 465 PRO Z 602 REMARK 465 TRP Z 603 REMARK 465 ASN Z 604 REMARK 465 SER Z 605 REMARK 465 THR Z 606 REMARK 465 TRP Z 607 REMARK 465 SER Z 608 REMARK 465 ASN Z 609 REMARK 465 LYS Z 610 REMARK 465 SER Z 611 REMARK 465 TYR Z 612 REMARK 465 GLU Z 613 REMARK 465 GLU Z 614 REMARK 465 ILE Z 615 REMARK 465 TRP Z 616 REMARK 465 ASN Z 617 REMARK 465 ASN Z 618 REMARK 465 MET Z 619 REMARK 465 THR Z 620 REMARK 465 TRP Z 621 REMARK 465 ILE Z 622 REMARK 465 GLU Z 623 REMARK 465 TRP Z 624 REMARK 465 GLU Z 625 REMARK 465 LYS Z 626 REMARK 465 GLU Z 627 REMARK 465 ILE Z 628 REMARK 465 SER Z 629 REMARK 465 ASN Z 630 REMARK 465 TYR Z 631 REMARK 465 THR Z 632 REMARK 465 ASN Z 633 REMARK 465 ARG Z 634 REMARK 465 ILE Z 635 REMARK 465 TYR Z 636 REMARK 465 ASP Z 637 REMARK 465 LEU Z 638 REMARK 465 LEU Z 639 REMARK 465 THR Z 640 REMARK 465 GLU Z 641 REMARK 465 SER Z 642 REMARK 465 GLN Z 643 REMARK 465 ASN Z 644 REMARK 465 GLN Z 645 REMARK 465 GLN Z 646 REMARK 465 GLU Z 647 REMARK 465 ARG Z 648 REMARK 465 ASN Z 649 REMARK 465 GLU Z 650 REMARK 465 LYS Z 651 REMARK 465 ASP Z 652 REMARK 465 LEU Z 653 REMARK 465 LEU Z 654 REMARK 465 GLU Z 655 REMARK 465 LEU Z 656 REMARK 465 ASP Z 657 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG SER A 69 OG SER A 82 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS X 247 CA - CB - SG ANGL. DEV. = 9.6 DEGREES REMARK 500 CYS Y 445 CA - CB - SG ANGL. DEV. = 6.6 DEGREES REMARK 500 CYS Z 247 CA - CB - SG ANGL. DEV. = 9.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ILE A 48 -60.74 -103.42 REMARK 500 ALA E 52 32.87 -141.90 REMARK 500 SER H 6 -179.49 -69.73 REMARK 500 ALA L 52 33.50 -141.40 REMARK 500 LEU R 523 13.95 57.86 REMARK 500 LYS X 232 35.79 -99.12 REMARK 500 GLN X 432 -112.69 59.55 REMARK 500 ASN Y 356 51.65 -92.63 REMARK 500 ARG Y 379 -1.15 63.52 REMARK 500 GLN Y 432 -71.08 62.76 REMARK 500 LEU Z 122 55.18 -92.91 REMARK 500 THR Z 137 30.63 -93.19 REMARK 500 GLN Z 432 -121.72 55.54 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 CYS Y 119 VAL Y 120 -149.72 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-34190 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-34192 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-34193 RELATED DB: EMDB REMARK 900 HIV-1 ENV X18 UFO IN COMPLEX WITH 8ANC195 FAB DBREF 8GPI A 0 234 PDB 8GPI 8GPI 0 234 DBREF 8GPI C 0 214 PDB 8GPI 8GPI 0 214 DBREF 8GPI D 0 234 PDB 8GPI 8GPI 0 234 DBREF 8GPI E 0 214 PDB 8GPI 8GPI 0 214 DBREF 8GPI H 0 234 PDB 8GPI 8GPI 0 234 DBREF 8GPI L 0 214 PDB 8GPI 8GPI 0 214 DBREF 8GPI R 30 664 PDB 8GPI 8GPI 30 664 DBREF 8GPI S 30 664 PDB 8GPI 8GPI 30 664 DBREF 8GPI T 30 664 PDB 8GPI 8GPI 30 664 DBREF 8GPI X 33 657 PDB 8GPI 8GPI 33 657 DBREF 8GPI Y 33 657 PDB 8GPI 8GPI 33 657 DBREF 8GPI Z 33 657 PDB 8GPI 8GPI 33 657 SEQRES 1 A 235 GLN ILE HIS LEU VAL GLN SER GLY THR GLU VAL LYS LYS SEQRES 2 A 235 PRO GLY SER SER VAL THR VAL SER CYS LYS ALA TYR GLY SEQRES 3 A 235 VAL ASN THR PHE GLY LEU TYR ALA VAL ASN TRP VAL ARG SEQRES 4 A 235 GLN ALA PRO GLY GLN SER LEU GLU TYR ILE GLY GLN ILE SEQRES 5 A 235 TRP ARG TRP LYS SER SER ALA SER HIS HIS PHE ARG GLY SEQRES 6 A 235 ARG VAL LEU ILE SER ALA VAL ASP LEU THR GLY SER SER SEQRES 7 A 235 PRO PRO ILE SER SER LEU GLU ILE LYS ASP LEU THR SER SEQRES 8 A 235 ASP ASP THR ALA VAL TYR PHE CYS THR THR THR SER THR SEQRES 9 A 235 TYR ASP LYS TRP SER GLY LEU HIS HIS ASP GLY VAL MET SEQRES 10 A 235 ALA PHE SER SER TRP GLY GLN GLY THR LEU ILE SER VAL SEQRES 11 A 235 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 A 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 A 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 A 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 A 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 A 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 A 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 A 235 SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER SEQRES 19 A 235 CYS SEQRES 1 C 215 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 C 215 SER ILE GLY ASP THR VAL ARG ILE SER CYS ARG ALA SER SEQRES 3 C 215 GLN SER ILE THR GLY ASN TRP VAL ALA TRP TYR GLN GLN SEQRES 4 C 215 ARG PRO GLY LYS ALA PRO ARG LEU LEU ILE TYR ARG GLY SEQRES 5 C 215 ALA ALA LEU LEU GLY GLY VAL PRO SER ARG PHE SER GLY SEQRES 6 C 215 SER ALA ALA GLY THR ASP PHE THR LEU THR ILE GLY ASN SEQRES 7 C 215 LEU GLN ALA GLU ASP PHE GLY THR PHE TYR CYS GLN GLN SEQRES 8 C 215 TYR ASP THR TYR PRO GLY THR PHE GLY GLN GLY THR LYS SEQRES 9 C 215 VAL GLU VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 C 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 C 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 C 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 C 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 C 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 C 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 C 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 C 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 D 235 GLN ILE HIS LEU VAL GLN SER GLY THR GLU VAL LYS LYS SEQRES 2 D 235 PRO GLY SER SER VAL THR VAL SER CYS LYS ALA TYR GLY SEQRES 3 D 235 VAL ASN THR PHE GLY LEU TYR ALA VAL ASN TRP VAL ARG SEQRES 4 D 235 GLN ALA PRO GLY GLN SER LEU GLU TYR ILE GLY GLN ILE SEQRES 5 D 235 TRP ARG TRP LYS SER SER ALA SER HIS HIS PHE ARG GLY SEQRES 6 D 235 ARG VAL LEU ILE SER ALA VAL ASP LEU THR GLY SER SER SEQRES 7 D 235 PRO PRO ILE SER SER LEU GLU ILE LYS ASP LEU THR SER SEQRES 8 D 235 ASP ASP THR ALA VAL TYR PHE CYS THR THR THR SER THR SEQRES 9 D 235 TYR ASP LYS TRP SER GLY LEU HIS HIS ASP GLY VAL MET SEQRES 10 D 235 ALA PHE SER SER TRP GLY GLN GLY THR LEU ILE SER VAL SEQRES 11 D 235 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 D 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 D 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 D 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 D 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 D 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 D 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 D 235 SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER SEQRES 19 D 235 CYS SEQRES 1 E 215 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 E 215 SER ILE GLY ASP THR VAL ARG ILE SER CYS ARG ALA SER SEQRES 3 E 215 GLN SER ILE THR GLY ASN TRP VAL ALA TRP TYR GLN GLN SEQRES 4 E 215 ARG PRO GLY LYS ALA PRO ARG LEU LEU ILE TYR ARG GLY SEQRES 5 E 215 ALA ALA LEU LEU GLY GLY VAL PRO SER ARG PHE SER GLY SEQRES 6 E 215 SER ALA ALA GLY THR ASP PHE THR LEU THR ILE GLY ASN SEQRES 7 E 215 LEU GLN ALA GLU ASP PHE GLY THR PHE TYR CYS GLN GLN SEQRES 8 E 215 TYR ASP THR TYR PRO GLY THR PHE GLY GLN GLY THR LYS SEQRES 9 E 215 VAL GLU VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 E 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 E 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 E 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 E 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 E 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 E 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 E 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 E 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 H 235 GLN ILE HIS LEU VAL GLN SER GLY THR GLU VAL LYS LYS SEQRES 2 H 235 PRO GLY SER SER VAL THR VAL SER CYS LYS ALA TYR GLY SEQRES 3 H 235 VAL ASN THR PHE GLY LEU TYR ALA VAL ASN TRP VAL ARG SEQRES 4 H 235 GLN ALA PRO GLY GLN SER LEU GLU TYR ILE GLY GLN ILE SEQRES 5 H 235 TRP ARG TRP LYS SER SER ALA SER HIS HIS PHE ARG GLY SEQRES 6 H 235 ARG VAL LEU ILE SER ALA VAL ASP LEU THR GLY SER SER SEQRES 7 H 235 PRO PRO ILE SER SER LEU GLU ILE LYS ASP LEU THR SER SEQRES 8 H 235 ASP ASP THR ALA VAL TYR PHE CYS THR THR THR SER THR SEQRES 9 H 235 TYR ASP LYS TRP SER GLY LEU HIS HIS ASP GLY VAL MET SEQRES 10 H 235 ALA PHE SER SER TRP GLY GLN GLY THR LEU ILE SER VAL SEQRES 11 H 235 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 H 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 H 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 H 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 H 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 H 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 H 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 H 235 SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER SEQRES 19 H 235 CYS SEQRES 1 L 215 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 L 215 SER ILE GLY ASP THR VAL ARG ILE SER CYS ARG ALA SER SEQRES 3 L 215 GLN SER ILE THR GLY ASN TRP VAL ALA TRP TYR GLN GLN SEQRES 4 L 215 ARG PRO GLY LYS ALA PRO ARG LEU LEU ILE TYR ARG GLY SEQRES 5 L 215 ALA ALA LEU LEU GLY GLY VAL PRO SER ARG PHE SER GLY SEQRES 6 L 215 SER ALA ALA GLY THR ASP PHE THR LEU THR ILE GLY ASN SEQRES 7 L 215 LEU GLN ALA GLU ASP PHE GLY THR PHE TYR CYS GLN GLN SEQRES 8 L 215 TYR ASP THR TYR PRO GLY THR PHE GLY GLN GLY THR LYS SEQRES 9 L 215 VAL GLU VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 R 622 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 R 622 ARG ASP ALA ASP THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 R 622 LYS ALA HIS VAL PRO GLU ALA HIS ASN VAL TRP ALA THR SEQRES 4 R 622 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 R 622 PRO LEU GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS SEQRES 6 R 622 ASN ASN MET VAL GLU GLN MET GLN GLU ASP VAL ILE SER SEQRES 7 R 622 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 R 622 PRO LEU CYS VAL THR LEU ASN CYS THR LYS ALA ASN LEU SEQRES 9 R 622 THR HIS ASN THR THR ASN ASP LYS ASN GLY THR GLY ASN SEQRES 10 R 622 ILE THR ASP GLU VAL LYS ILE GLY ASN ILE THR ASP GLU SEQRES 11 R 622 VAL LYS ASN CYS THR PHE ASN MET THR THR GLU ILE ARG SEQRES 12 R 622 ASP LYS GLN GLN LYS VAL HIS ALA LEU PHE TYR ALA LEU SEQRES 13 R 622 ASP ILE VAL GLN MET LYS GLU ASN GLY SER GLU TYR ARG SEQRES 14 R 622 LEU ILE SER CYS ASN THR SER VAL ILE LYS GLN ALA CYS SEQRES 15 R 622 PRO LYS ILE SER PHE ASP PRO ILE PRO ILE HIS TYR CYS SEQRES 16 R 622 ALA PRO ALA GLY TYR ALA ILE LEU LYS CYS ASN ASP LYS SEQRES 17 R 622 LYS PHE ASN GLY THR GLY PRO CYS LYS ASN VAL SER THR SEQRES 18 R 622 VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SER THR SEQRES 19 R 622 GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU GLU ILE SEQRES 20 R 622 ILE ILE ARG SER GLU ASN LEU THR ASN ASN ALA LYS ASN SEQRES 21 R 622 ILE ILE VAL HIS LEU ASN LYS SER VAL SER ILE SER CYS SEQRES 22 R 622 THR ARG PRO SER ASN ASN THR ARG THR SER ILE ARG ILE SEQRES 23 R 622 GLY PRO GLY GLN MET PHE TYR ARG THR GLY ASP ILE ILE SEQRES 24 R 622 GLY ASP ILE ARG LYS ALA TYR CYS GLU LEU ASN GLY THR SEQRES 25 R 622 GLU TRP ASN GLU THR LEU ASN LYS VAL THR GLU LYS LEU SEQRES 26 R 622 LYS GLU HIS PHE ASN LYS THR ILE VAL PHE GLN PRO PRO SEQRES 27 R 622 SER GLY GLY ASP LEU GLU THR THR MET HIS HIS PHE ASN SEQRES 28 R 622 CYS ARG GLY GLU PHE PHE TYR CYS ASN THR THR LYS LEU SEQRES 29 R 622 PHE ASN THR LYS ASN GLY THR ARG GLU GLU PHE ASN GLY SEQRES 30 R 622 THR ILE ILE LEU PRO CYS ARG ILE LYS GLN ILE VAL ASN SEQRES 31 R 622 MET TRP GLN GLY VAL GLY GLN ALA MET TYR ALA PRO PRO SEQRES 32 R 622 ILE SER GLY ILE ILE ASN CYS THR SER ASN ILE THR GLY SEQRES 33 R 622 ILE ILE LEU THR ARG ASP GLY GLY ASN GLY ASN THR THR SEQRES 34 R 622 ASP GLU THR PHE ARG PRO GLY GLY GLY ASN ILE LYS ASP SEQRES 35 R 622 ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL GLN SEQRES 36 R 622 ILE GLU PRO LEU GLY ILE ALA PRO THR ARG CYS LYS ARG SEQRES 37 R 622 ARG VAL VAL ASP GLY GLY GLY GLY SER GLY GLY GLY GLY SEQRES 38 R 622 SER ALA VAL GLY ILE GLY ALA MET ILE PHE GLY PHE LEU SEQRES 39 R 622 GLY ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR SEQRES 40 R 622 LEU THR VAL GLN ALA ARG GLN LEU LEU SER GLY ASN PRO SEQRES 41 R 622 ASP TRP LEU PRO ASP MET THR VAL TRP GLY ILE LYS GLN SEQRES 42 R 622 LEU GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS SEQRES 43 R 622 ASP GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS SEQRES 44 R 622 ILE ILE CYS CYS THR ASN VAL PRO TRP ASN SER THR TRP SEQRES 45 R 622 SER ASN LYS SER TYR GLU GLU ILE TRP ASN ASN MET THR SEQRES 46 R 622 TRP ILE GLU TRP GLU LYS GLU ILE SER ASN TYR THR ASN SEQRES 47 R 622 ARG ILE TYR ASP LEU LEU THR GLU SER GLN ASN GLN GLN SEQRES 48 R 622 GLU ARG ASN GLU LYS ASP LEU LEU GLU LEU ASP SEQRES 1 S 622 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 S 622 ARG ASP ALA ASP THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 S 622 LYS ALA HIS VAL PRO GLU ALA HIS ASN VAL TRP ALA THR SEQRES 4 S 622 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 S 622 PRO LEU GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS SEQRES 6 S 622 ASN ASN MET VAL GLU GLN MET GLN GLU ASP VAL ILE SER SEQRES 7 S 622 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 S 622 PRO LEU CYS VAL THR LEU ASN CYS THR LYS ALA ASN LEU SEQRES 9 S 622 THR HIS ASN THR THR ASN ASP LYS ASN GLY THR GLY ASN SEQRES 10 S 622 ILE THR ASP GLU VAL LYS ILE GLY ASN ILE THR ASP GLU SEQRES 11 S 622 VAL LYS ASN CYS THR PHE ASN MET THR THR GLU ILE ARG SEQRES 12 S 622 ASP LYS GLN GLN LYS VAL HIS ALA LEU PHE TYR ALA LEU SEQRES 13 S 622 ASP ILE VAL GLN MET LYS GLU ASN GLY SER GLU TYR ARG SEQRES 14 S 622 LEU ILE SER CYS ASN THR SER VAL ILE LYS GLN ALA CYS SEQRES 15 S 622 PRO LYS ILE SER PHE ASP PRO ILE PRO ILE HIS TYR CYS SEQRES 16 S 622 ALA PRO ALA GLY TYR ALA ILE LEU LYS CYS ASN ASP LYS SEQRES 17 S 622 LYS PHE ASN GLY THR GLY PRO CYS LYS ASN VAL SER THR SEQRES 18 S 622 VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SER THR SEQRES 19 S 622 GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU GLU ILE SEQRES 20 S 622 ILE ILE ARG SER GLU ASN LEU THR ASN ASN ALA LYS ASN SEQRES 21 S 622 ILE ILE VAL HIS LEU ASN LYS SER VAL SER ILE SER CYS SEQRES 22 S 622 THR ARG PRO SER ASN ASN THR ARG THR SER ILE ARG ILE SEQRES 23 S 622 GLY PRO GLY GLN MET PHE TYR ARG THR GLY ASP ILE ILE SEQRES 24 S 622 GLY ASP ILE ARG LYS ALA TYR CYS GLU LEU ASN GLY THR SEQRES 25 S 622 GLU TRP ASN GLU THR LEU ASN LYS VAL THR GLU LYS LEU SEQRES 26 S 622 LYS GLU HIS PHE ASN LYS THR ILE VAL PHE GLN PRO PRO SEQRES 27 S 622 SER GLY GLY ASP LEU GLU THR THR MET HIS HIS PHE ASN SEQRES 28 S 622 CYS ARG GLY GLU PHE PHE TYR CYS ASN THR THR LYS LEU SEQRES 29 S 622 PHE ASN THR LYS ASN GLY THR ARG GLU GLU PHE ASN GLY SEQRES 30 S 622 THR ILE ILE LEU PRO CYS ARG ILE LYS GLN ILE VAL ASN SEQRES 31 S 622 MET TRP GLN GLY VAL GLY GLN ALA MET TYR ALA PRO PRO SEQRES 32 S 622 ILE SER GLY ILE ILE ASN CYS THR SER ASN ILE THR GLY SEQRES 33 S 622 ILE ILE LEU THR ARG ASP GLY GLY ASN GLY ASN THR THR SEQRES 34 S 622 ASP GLU THR PHE ARG PRO GLY GLY GLY ASN ILE LYS ASP SEQRES 35 S 622 ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL GLN SEQRES 36 S 622 ILE GLU PRO LEU GLY ILE ALA PRO THR ARG CYS LYS ARG SEQRES 37 S 622 ARG VAL VAL ASP GLY GLY GLY GLY SER GLY GLY GLY GLY SEQRES 38 S 622 SER ALA VAL GLY ILE GLY ALA MET ILE PHE GLY PHE LEU SEQRES 39 S 622 GLY ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR SEQRES 40 S 622 LEU THR VAL GLN ALA ARG GLN LEU LEU SER GLY ASN PRO SEQRES 41 S 622 ASP TRP LEU PRO ASP MET THR VAL TRP GLY ILE LYS GLN SEQRES 42 S 622 LEU GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS SEQRES 43 S 622 ASP GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS SEQRES 44 S 622 ILE ILE CYS CYS THR ASN VAL PRO TRP ASN SER THR TRP SEQRES 45 S 622 SER ASN LYS SER TYR GLU GLU ILE TRP ASN ASN MET THR SEQRES 46 S 622 TRP ILE GLU TRP GLU LYS GLU ILE SER ASN TYR THR ASN SEQRES 47 S 622 ARG ILE TYR ASP LEU LEU THR GLU SER GLN ASN GLN GLN SEQRES 48 S 622 GLU ARG ASN GLU LYS ASP LEU LEU GLU LEU ASP SEQRES 1 T 622 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 T 622 ARG ASP ALA ASP THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 T 622 LYS ALA HIS VAL PRO GLU ALA HIS ASN VAL TRP ALA THR SEQRES 4 T 622 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 T 622 PRO LEU GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS SEQRES 6 T 622 ASN ASN MET VAL GLU GLN MET GLN GLU ASP VAL ILE SER SEQRES 7 T 622 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 T 622 PRO LEU CYS VAL THR LEU ASN CYS THR LYS ALA ASN LEU SEQRES 9 T 622 THR HIS ASN THR THR ASN ASP LYS ASN GLY THR GLY ASN SEQRES 10 T 622 ILE THR ASP GLU VAL LYS ILE GLY ASN ILE THR ASP GLU SEQRES 11 T 622 VAL LYS ASN CYS THR PHE ASN MET THR THR GLU ILE ARG SEQRES 12 T 622 ASP LYS GLN GLN LYS VAL HIS ALA LEU PHE TYR ALA LEU SEQRES 13 T 622 ASP ILE VAL GLN MET LYS GLU ASN GLY SER GLU TYR ARG SEQRES 14 T 622 LEU ILE SER CYS ASN THR SER VAL ILE LYS GLN ALA CYS SEQRES 15 T 622 PRO LYS ILE SER PHE ASP PRO ILE PRO ILE HIS TYR CYS SEQRES 16 T 622 ALA PRO ALA GLY TYR ALA ILE LEU LYS CYS ASN ASP LYS SEQRES 17 T 622 LYS PHE ASN GLY THR GLY PRO CYS LYS ASN VAL SER THR SEQRES 18 T 622 VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SER THR SEQRES 19 T 622 GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU GLU ILE SEQRES 20 T 622 ILE ILE ARG SER GLU ASN LEU THR ASN ASN ALA LYS ASN SEQRES 21 T 622 ILE ILE VAL HIS LEU ASN LYS SER VAL SER ILE SER CYS SEQRES 22 T 622 THR ARG PRO SER ASN ASN THR ARG THR SER ILE ARG ILE SEQRES 23 T 622 GLY PRO GLY GLN MET PHE TYR ARG THR GLY ASP ILE ILE SEQRES 24 T 622 GLY ASP ILE ARG LYS ALA TYR CYS GLU LEU ASN GLY THR SEQRES 25 T 622 GLU TRP ASN GLU THR LEU ASN LYS VAL THR GLU LYS LEU SEQRES 26 T 622 LYS GLU HIS PHE ASN LYS THR ILE VAL PHE GLN PRO PRO SEQRES 27 T 622 SER GLY GLY ASP LEU GLU THR THR MET HIS HIS PHE ASN SEQRES 28 T 622 CYS ARG GLY GLU PHE PHE TYR CYS ASN THR THR LYS LEU SEQRES 29 T 622 PHE ASN THR LYS ASN GLY THR ARG GLU GLU PHE ASN GLY SEQRES 30 T 622 THR ILE ILE LEU PRO CYS ARG ILE LYS GLN ILE VAL ASN SEQRES 31 T 622 MET TRP GLN GLY VAL GLY GLN ALA MET TYR ALA PRO PRO SEQRES 32 T 622 ILE SER GLY ILE ILE ASN CYS THR SER ASN ILE THR GLY SEQRES 33 T 622 ILE ILE LEU THR ARG ASP GLY GLY ASN GLY ASN THR THR SEQRES 34 T 622 ASP GLU THR PHE ARG PRO GLY GLY GLY ASN ILE LYS ASP SEQRES 35 T 622 ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL GLN SEQRES 36 T 622 ILE GLU PRO LEU GLY ILE ALA PRO THR ARG CYS LYS ARG SEQRES 37 T 622 ARG VAL VAL ASP GLY GLY GLY GLY SER GLY GLY GLY GLY SEQRES 38 T 622 SER ALA VAL GLY ILE GLY ALA MET ILE PHE GLY PHE LEU SEQRES 39 T 622 GLY ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR SEQRES 40 T 622 LEU THR VAL GLN ALA ARG GLN LEU LEU SER GLY ASN PRO SEQRES 41 T 622 ASP TRP LEU PRO ASP MET THR VAL TRP GLY ILE LYS GLN SEQRES 42 T 622 LEU GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS SEQRES 43 T 622 ASP GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS SEQRES 44 T 622 ILE ILE CYS CYS THR ASN VAL PRO TRP ASN SER THR TRP SEQRES 45 T 622 SER ASN LYS SER TYR GLU GLU ILE TRP ASN ASN MET THR SEQRES 46 T 622 TRP ILE GLU TRP GLU LYS GLU ILE SER ASN TYR THR ASN SEQRES 47 T 622 ARG ILE TYR ASP LEU LEU THR GLU SER GLN ASN GLN GLN SEQRES 48 T 622 GLU ARG ASN GLU LYS ASP LEU LEU GLU LEU ASP SEQRES 1 X 622 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 X 622 ARG ASP ALA ASP THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 X 622 LYS ALA HIS VAL PRO GLU ALA HIS ASN VAL TRP ALA THR SEQRES 4 X 622 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 X 622 PRO LEU GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS SEQRES 6 X 622 ASN ASN MET VAL GLU GLN MET GLN GLU ASP VAL ILE SER SEQRES 7 X 622 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 X 622 PRO LEU CYS VAL THR LEU ASN CYS THR LYS ALA ASN LEU SEQRES 9 X 622 THR HIS ASN THR THR ASN ASP LYS ASN GLY THR GLY ASN SEQRES 10 X 622 ILE THR ASP GLU VAL LYS ILE GLY ASN ILE THR ASP GLU SEQRES 11 X 622 VAL LYS ASN CYS THR PHE ASN MET THR THR GLU ILE ARG SEQRES 12 X 622 ASP LYS GLN GLN LYS VAL HIS ALA LEU PHE TYR ALA LEU SEQRES 13 X 622 ASP ILE VAL GLN MET LYS GLU ASN GLY SER GLU TYR ARG SEQRES 14 X 622 LEU ILE SER CYS ASN THR SER VAL ILE LYS GLN ALA CYS SEQRES 15 X 622 PRO LYS ILE SER PHE ASP PRO ILE PRO ILE HIS TYR CYS SEQRES 16 X 622 ALA PRO ALA GLY TYR ALA ILE LEU LYS CYS ASN ASP LYS SEQRES 17 X 622 LYS PHE ASN GLY THR GLY PRO CYS LYS ASN VAL SER THR SEQRES 18 X 622 VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SER THR SEQRES 19 X 622 GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU GLU ILE SEQRES 20 X 622 ILE ILE ARG SER GLU ASN LEU THR ASN ASN ALA LYS ASN SEQRES 21 X 622 ILE ILE VAL HIS LEU ASN LYS SER VAL SER ILE SER CYS SEQRES 22 X 622 THR ARG PRO SER ASN ASN THR ARG THR SER ILE ARG ILE SEQRES 23 X 622 GLY PRO GLY GLN MET PHE TYR ARG THR GLY ASP ILE ILE SEQRES 24 X 622 GLY ASP ILE ARG LYS ALA TYR CYS GLU LEU ASN GLY THR SEQRES 25 X 622 GLU TRP ASN GLU THR LEU ASN LYS VAL THR GLU LYS LEU SEQRES 26 X 622 LYS GLU HIS PHE ASN LYS THR ILE VAL PHE GLN PRO PRO SEQRES 27 X 622 SER GLY GLY ASP LEU GLU THR THR MET HIS HIS PHE ASN SEQRES 28 X 622 CYS ARG GLY GLU PHE PHE TYR CYS ASN THR THR LYS LEU SEQRES 29 X 622 PHE ASN THR LYS ASN GLY THR ARG GLU GLU PHE ASN GLY SEQRES 30 X 622 THR ILE ILE LEU PRO CYS ARG ILE LYS GLN ILE VAL ASN SEQRES 31 X 622 MET TRP GLN GLY VAL GLY GLN ALA MET TYR ALA PRO PRO SEQRES 32 X 622 ILE SER GLY ILE ILE ASN CYS THR SER ASN ILE THR GLY SEQRES 33 X 622 ILE ILE LEU THR ARG ASP GLY GLY ASN GLY ASN THR THR SEQRES 34 X 622 ASP GLU THR PHE ARG PRO GLY GLY GLY ASN ILE LYS ASP SEQRES 35 X 622 ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL GLN SEQRES 36 X 622 ILE GLU PRO LEU GLY ILE ALA PRO THR ARG CYS LYS ARG SEQRES 37 X 622 ARG VAL VAL ASP GLY GLY GLY GLY SER GLY GLY GLY GLY SEQRES 38 X 622 SER ALA VAL GLY ILE GLY ALA MET ILE PHE GLY PHE LEU SEQRES 39 X 622 GLY ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR SEQRES 40 X 622 LEU THR VAL GLN ALA ARG GLN LEU LEU SER GLY ASN PRO SEQRES 41 X 622 ASP TRP LEU PRO ASP MET THR VAL TRP GLY ILE LYS GLN SEQRES 42 X 622 LEU GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS SEQRES 43 X 622 ASP GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS SEQRES 44 X 622 ILE ILE CYS CYS THR ASN VAL PRO TRP ASN SER THR TRP SEQRES 45 X 622 SER ASN LYS SER TYR GLU GLU ILE TRP ASN ASN MET THR SEQRES 46 X 622 TRP ILE GLU TRP GLU LYS GLU ILE SER ASN TYR THR ASN SEQRES 47 X 622 ARG ILE TYR ASP LEU LEU THR GLU SER GLN ASN GLN GLN SEQRES 48 X 622 GLU ARG ASN GLU LYS ASP LEU LEU GLU LEU ASP SEQRES 1 Y 622 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 Y 622 ARG ASP ALA ASP THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 Y 622 LYS ALA HIS VAL PRO GLU ALA HIS ASN VAL TRP ALA THR SEQRES 4 Y 622 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 Y 622 PRO LEU GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS SEQRES 6 Y 622 ASN ASN MET VAL GLU GLN MET GLN GLU ASP VAL ILE SER SEQRES 7 Y 622 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 Y 622 PRO LEU CYS VAL THR LEU ASN CYS THR LYS ALA ASN LEU SEQRES 9 Y 622 THR HIS ASN THR THR ASN ASP LYS ASN GLY THR GLY ASN SEQRES 10 Y 622 ILE THR ASP GLU VAL LYS ILE GLY ASN ILE THR ASP GLU SEQRES 11 Y 622 VAL LYS ASN CYS THR PHE ASN MET THR THR GLU ILE ARG SEQRES 12 Y 622 ASP LYS GLN GLN LYS VAL HIS ALA LEU PHE TYR ALA LEU SEQRES 13 Y 622 ASP ILE VAL GLN MET LYS GLU ASN GLY SER GLU TYR ARG SEQRES 14 Y 622 LEU ILE SER CYS ASN THR SER VAL ILE LYS GLN ALA CYS SEQRES 15 Y 622 PRO LYS ILE SER PHE ASP PRO ILE PRO ILE HIS TYR CYS SEQRES 16 Y 622 ALA PRO ALA GLY TYR ALA ILE LEU LYS CYS ASN ASP LYS SEQRES 17 Y 622 LYS PHE ASN GLY THR GLY PRO CYS LYS ASN VAL SER THR SEQRES 18 Y 622 VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SER THR SEQRES 19 Y 622 GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU GLU ILE SEQRES 20 Y 622 ILE ILE ARG SER GLU ASN LEU THR ASN ASN ALA LYS ASN SEQRES 21 Y 622 ILE ILE VAL HIS LEU ASN LYS SER VAL SER ILE SER CYS SEQRES 22 Y 622 THR ARG PRO SER ASN ASN THR ARG THR SER ILE ARG ILE SEQRES 23 Y 622 GLY PRO GLY GLN MET PHE TYR ARG THR GLY ASP ILE ILE SEQRES 24 Y 622 GLY ASP ILE ARG LYS ALA TYR CYS GLU LEU ASN GLY THR SEQRES 25 Y 622 GLU TRP ASN GLU THR LEU ASN LYS VAL THR GLU LYS LEU SEQRES 26 Y 622 LYS GLU HIS PHE ASN LYS THR ILE VAL PHE GLN PRO PRO SEQRES 27 Y 622 SER GLY GLY ASP LEU GLU THR THR MET HIS HIS PHE ASN SEQRES 28 Y 622 CYS ARG GLY GLU PHE PHE TYR CYS ASN THR THR LYS LEU SEQRES 29 Y 622 PHE ASN THR LYS ASN GLY THR ARG GLU GLU PHE ASN GLY SEQRES 30 Y 622 THR ILE ILE LEU PRO CYS ARG ILE LYS GLN ILE VAL ASN SEQRES 31 Y 622 MET TRP GLN GLY VAL GLY GLN ALA MET TYR ALA PRO PRO SEQRES 32 Y 622 ILE SER GLY ILE ILE ASN CYS THR SER ASN ILE THR GLY SEQRES 33 Y 622 ILE ILE LEU THR ARG ASP GLY GLY ASN GLY ASN THR THR SEQRES 34 Y 622 ASP GLU THR PHE ARG PRO GLY GLY GLY ASN ILE LYS ASP SEQRES 35 Y 622 ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL GLN SEQRES 36 Y 622 ILE GLU PRO LEU GLY ILE ALA PRO THR ARG CYS LYS ARG SEQRES 37 Y 622 ARG VAL VAL ASP GLY GLY GLY GLY SER GLY GLY GLY GLY SEQRES 38 Y 622 SER ALA VAL GLY ILE GLY ALA MET ILE PHE GLY PHE LEU SEQRES 39 Y 622 GLY ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR SEQRES 40 Y 622 LEU THR VAL GLN ALA ARG GLN LEU LEU SER GLY ASN PRO SEQRES 41 Y 622 ASP TRP LEU PRO ASP MET THR VAL TRP GLY ILE LYS GLN SEQRES 42 Y 622 LEU GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS SEQRES 43 Y 622 ASP GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS SEQRES 44 Y 622 ILE ILE CYS CYS THR ASN VAL PRO TRP ASN SER THR TRP SEQRES 45 Y 622 SER ASN LYS SER TYR GLU GLU ILE TRP ASN ASN MET THR SEQRES 46 Y 622 TRP ILE GLU TRP GLU LYS GLU ILE SER ASN TYR THR ASN SEQRES 47 Y 622 ARG ILE TYR ASP LEU LEU THR GLU SER GLN ASN GLN GLN SEQRES 48 Y 622 GLU ARG ASN GLU LYS ASP LEU LEU GLU LEU ASP SEQRES 1 Z 622 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 Z 622 ARG ASP ALA ASP THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 Z 622 LYS ALA HIS VAL PRO GLU ALA HIS ASN VAL TRP ALA THR SEQRES 4 Z 622 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 Z 622 PRO LEU GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS SEQRES 6 Z 622 ASN ASN MET VAL GLU GLN MET GLN GLU ASP VAL ILE SER SEQRES 7 Z 622 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 Z 622 PRO LEU CYS VAL THR LEU ASN CYS THR LYS ALA ASN LEU SEQRES 9 Z 622 THR HIS ASN THR THR ASN ASP LYS ASN GLY THR GLY ASN SEQRES 10 Z 622 ILE THR ASP GLU VAL LYS ILE GLY ASN ILE THR ASP GLU SEQRES 11 Z 622 VAL LYS ASN CYS THR PHE ASN MET THR THR GLU ILE ARG SEQRES 12 Z 622 ASP LYS GLN GLN LYS VAL HIS ALA LEU PHE TYR ALA LEU SEQRES 13 Z 622 ASP ILE VAL GLN MET LYS GLU ASN GLY SER GLU TYR ARG SEQRES 14 Z 622 LEU ILE SER CYS ASN THR SER VAL ILE LYS GLN ALA CYS SEQRES 15 Z 622 PRO LYS ILE SER PHE ASP PRO ILE PRO ILE HIS TYR CYS SEQRES 16 Z 622 ALA PRO ALA GLY TYR ALA ILE LEU LYS CYS ASN ASP LYS SEQRES 17 Z 622 LYS PHE ASN GLY THR GLY PRO CYS LYS ASN VAL SER THR SEQRES 18 Z 622 VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SER THR SEQRES 19 Z 622 GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU GLU ILE SEQRES 20 Z 622 ILE ILE ARG SER GLU ASN LEU THR ASN ASN ALA LYS ASN SEQRES 21 Z 622 ILE ILE VAL HIS LEU ASN LYS SER VAL SER ILE SER CYS SEQRES 22 Z 622 THR ARG PRO SER ASN ASN THR ARG THR SER ILE ARG ILE SEQRES 23 Z 622 GLY PRO GLY GLN MET PHE TYR ARG THR GLY ASP ILE ILE SEQRES 24 Z 622 GLY ASP ILE ARG LYS ALA TYR CYS GLU LEU ASN GLY THR SEQRES 25 Z 622 GLU TRP ASN GLU THR LEU ASN LYS VAL THR GLU LYS LEU SEQRES 26 Z 622 LYS GLU HIS PHE ASN LYS THR ILE VAL PHE GLN PRO PRO SEQRES 27 Z 622 SER GLY GLY ASP LEU GLU THR THR MET HIS HIS PHE ASN SEQRES 28 Z 622 CYS ARG GLY GLU PHE PHE TYR CYS ASN THR THR LYS LEU SEQRES 29 Z 622 PHE ASN THR LYS ASN GLY THR ARG GLU GLU PHE ASN GLY SEQRES 30 Z 622 THR ILE ILE LEU PRO CYS ARG ILE LYS GLN ILE VAL ASN SEQRES 31 Z 622 MET TRP GLN GLY VAL GLY GLN ALA MET TYR ALA PRO PRO SEQRES 32 Z 622 ILE SER GLY ILE ILE ASN CYS THR SER ASN ILE THR GLY SEQRES 33 Z 622 ILE ILE LEU THR ARG ASP GLY GLY ASN GLY ASN THR THR SEQRES 34 Z 622 ASP GLU THR PHE ARG PRO GLY GLY GLY ASN ILE LYS ASP SEQRES 35 Z 622 ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL GLN SEQRES 36 Z 622 ILE GLU PRO LEU GLY ILE ALA PRO THR ARG CYS LYS ARG SEQRES 37 Z 622 ARG VAL VAL ASP GLY GLY GLY GLY SER GLY GLY GLY GLY SEQRES 38 Z 622 SER ALA VAL GLY ILE GLY ALA MET ILE PHE GLY PHE LEU SEQRES 39 Z 622 GLY ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR SEQRES 40 Z 622 LEU THR VAL GLN ALA ARG GLN LEU LEU SER GLY ASN PRO SEQRES 41 Z 622 ASP TRP LEU PRO ASP MET THR VAL TRP GLY ILE LYS GLN SEQRES 42 Z 622 LEU GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS SEQRES 43 Z 622 ASP GLN LYS PHE LEU GLY LEU TRP GLY CYS SER GLY LYS SEQRES 44 Z 622 ILE ILE CYS CYS THR ASN VAL PRO TRP ASN SER THR TRP SEQRES 45 Z 622 SER ASN LYS SER TYR GLU GLU ILE TRP ASN ASN MET THR SEQRES 46 Z 622 TRP ILE GLU TRP GLU LYS GLU ILE SER ASN TYR THR ASN SEQRES 47 Z 622 ARG ILE TYR ASP LEU LEU THR GLU SER GLN ASN GLN GLN SEQRES 48 Z 622 GLU ARG ASN GLU LYS ASP LEU LEU GLU LEU ASP HET NAG R 701 14 HET NAG S 701 14 HET NAG T 701 14 HET NAG X 701 14 HET NAG X 702 14 HET NAG X 703 14 HET NAG X 704 14 HET NAG X 705 14 HET NAG X 706 14 HET NAG X 707 14 HET NAG X 708 14 HET NAG Y 701 14 HET NAG Y 702 14 HET NAG Y 703 14 HET NAG Y 704 14 HET NAG Y 705 14 HET NAG Y 706 14 HET NAG Y 707 14 HET NAG Y 708 14 HET NAG Y 709 14 HET NAG Z 701 14 HET NAG Z 702 14 HET NAG Z 703 14 HET NAG Z 704 14 HET NAG Z 705 14 HET NAG Z 706 14 HET NAG Z 707 14 HET NAG Z 708 14 HET NAG Z 709 14 HET NAG B 1 14 HET NAG B 2 14 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HET BMA K 3 11 HET MAN K 4 11 HET MAN K 5 11 HET MAN K 6 11 HET MAN K 7 11 HET MAN K 8 11 HET MAN K 9 11 HET MAN K 10 11 HET MAN K 11 11 HET NAG M 1 14 HET NAG M 2 14 HET BMA M 3 11 HET MAN M 4 11 HET MAN M 5 11 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET BMA b 3 11 HET MAN b 4 11 HET MAN b 5 11 HET MAN b 6 11 HET MAN b 7 11 HET MAN b 8 11 HET MAN b 9 11 HET MAN b 10 11 HET MAN b 11 11 HET NAG c 1 14 HET NAG c 2 14 HET BMA c 3 11 HET MAN c 4 11 HET MAN c 5 11 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET NAG e 1 14 HET NAG e 2 14 HET NAG f 1 14 HET NAG f 2 14 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET NAG i 1 14 HET NAG i 2 14 HET NAG j 1 14 HET NAG j 2 14 HET NAG k 1 14 HET NAG k 2 14 HET BMA k 3 11 HET MAN k 4 11 HET MAN k 5 11 HET MAN k 6 11 HET MAN k 7 11 HET MAN k 8 11 HET MAN k 9 11 HET MAN k 10 11 HET MAN k 11 11 HET NAG l 1 14 HET NAG l 2 14 HET BMA l 3 11 HET MAN l 4 11 HET MAN l 5 11 HET NAG m 1 14 HET NAG m 2 14 HET BMA m 3 11 HET NAG n 1 14 HET NAG n 2 14 HET NAG o 1 14 HET NAG o 2 14 HET NAG p 1 14 HET NAG p 2 14 HET NAG q 1 14 HET NAG q 2 14 HET NAG r 1 14 HET NAG r 2 14 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 13 NAG 93(C8 H15 N O6) FORMUL 47 BMA 9(C6 H12 O6) FORMUL 47 MAN 30(C6 H12 O6) HELIX 1 AA1 HIS A 60 ARG A 63 5 4 HELIX 2 AA2 THR A 89 THR A 93 5 5 HELIX 3 AA3 GLN C 79 PHE C 83 5 5 HELIX 4 AA4 HIS D 60 ARG D 63 5 4 HELIX 5 AA5 THR D 89 THR D 93 5 5 HELIX 6 AA6 GLN E 79 PHE E 83 5 5 HELIX 7 AA7 HIS H 60 ARG H 63 5 4 HELIX 8 AA8 THR H 89 THR H 93 5 5 HELIX 9 AA9 THR R 529 SER R 534 1 6 HELIX 10 AB1 THR R 536 LEU R 544 1 9 HELIX 11 AB2 GLY R 572 TRP R 596 1 25 HELIX 12 AB3 SER R 618 ASN R 625 1 8 HELIX 13 AB4 THR R 627 ILE R 635 1 9 HELIX 14 AB5 TYR R 638 LEU R 663 1 26 HELIX 15 AB6 THR S 529 SER S 534 1 6 HELIX 16 AB7 LEU S 537 LEU S 544 1 8 HELIX 17 AB8 GLY S 572 TRP S 596 1 25 HELIX 18 AB9 SER S 618 ASN S 625 1 8 HELIX 19 AC1 THR S 627 ILE S 635 1 9 HELIX 20 AC2 TYR S 638 LEU S 663 1 26 HELIX 21 AC3 THR T 529 SER T 534 1 6 HELIX 22 AC4 THR T 538 LEU T 544 1 7 HELIX 23 AC5 GLY T 572 TRP T 596 1 25 HELIX 24 AC6 SER T 618 ASN T 625 1 8 HELIX 25 AC7 THR T 627 ILE T 635 1 9 HELIX 26 AC8 TYR T 638 LEU T 663 1 26 HELIX 27 AC9 ASN X 98 LYS X 117 1 20 HELIX 28 AD1 LEU X 122 CYS X 126 5 5 HELIX 29 AD2 SER X 195 THR X 198 5 4 HELIX 30 AD3 GLY X 335 LYS X 350 1 16 HELIX 31 AD4 LYS X 476 SER X 481 1 6 HELIX 32 AD5 ASN Y 98 LEU Y 116 1 19 HELIX 33 AD6 LEU Y 122 CYS Y 126 5 5 HELIX 34 AD7 GLY Y 335 LYS Y 350 1 16 HELIX 35 AD8 ASP Y 368 MET Y 373 1 6 HELIX 36 AD9 LYS Y 476 TYR Y 484 1 9 HELIX 37 AE1 ASN Z 98 LEU Z 116 1 19 HELIX 38 AE2 THR Z 123 CYS Z 126 5 4 HELIX 39 AE3 ASN Z 149 ASP Z 152 5 4 HELIX 40 AE4 SER Z 195 THR Z 198 5 4 HELIX 41 AE5 GLY Z 335 LYS Z 350 1 16 HELIX 42 AE6 ASP Z 368 MET Z 373 1 6 HELIX 43 AE7 ILE Z 475 TYR Z 484 1 10 SHEET 1 AA1 4 HIS A 2 GLN A 5 0 SHEET 2 AA1 4 VAL A 17 TYR A 24 -1 O LYS A 22 N VAL A 4 SHEET 3 AA1 4 ILE A 80 ILE A 85 -1 O LEU A 83 N VAL A 19 SHEET 4 AA1 4 VAL A 66 VAL A 71 -1 N SER A 69 O SER A 82 SHEET 1 AA2 7 GLU A 9 VAL A 10 0 SHEET 2 AA2 7 TYR A 32 GLN A 39 0 SHEET 3 AA2 7 LEU A 45 TRP A 52 -1 O GLU A 46 N ARG A 38 SHEET 4 AA2 7 LYS A 55 ALA A 58 -1 O SER A 57 N GLN A 50 SHEET 5 AA2 7 ALA A 94 SER A 102 -1 O PHE A 97 N VAL A 37 SHEET 6 AA2 7 SER A 120 TRP A 121 -1 O SER A 120 N THR A 100 SHEET 7 AA2 7 THR A 125 SER A 128 -1 O ILE A 127 N ALA A 94 SHEET 1 AA3 2 HIS A 111 HIS A 112 0 SHEET 2 AA3 2 VAL A 115 MET A 116 -1 O VAL A 115 N HIS A 112 SHEET 1 AA4 4 MET C 3 GLN C 5 0 SHEET 2 AA4 4 VAL C 18 ALA C 24 -1 O ARG C 23 N THR C 4 SHEET 3 AA4 4 ASP C 70 ILE C 75 -1 O PHE C 71 N CYS C 22 SHEET 4 AA4 4 PHE C 62 ALA C 67 -1 N ALA C 67 O ASP C 70 SHEET 1 AA5 6 THR C 9 LEU C 10 0 SHEET 2 AA5 6 THR C 102 VAL C 104 1 O LYS C 103 N LEU C 10 SHEET 3 AA5 6 GLY C 84 GLN C 90 -1 N GLY C 84 O VAL C 104 SHEET 4 AA5 6 VAL C 33 GLN C 38 -1 N TYR C 36 O TYR C 87 SHEET 5 AA5 6 ARG C 45 TYR C 49 -1 O ARG C 45 N GLN C 37 SHEET 6 AA5 6 ALA C 53 LEU C 54 -1 O ALA C 53 N TYR C 49 SHEET 1 AA6 4 HIS D 2 GLN D 5 0 SHEET 2 AA6 4 VAL D 17 TYR D 24 -1 O LYS D 22 N VAL D 4 SHEET 3 AA6 4 ILE D 80 ILE D 85 -1 O LEU D 83 N VAL D 19 SHEET 4 AA6 4 VAL D 66 VAL D 71 -1 N SER D 69 O SER D 82 SHEET 1 AA7 7 GLU D 9 VAL D 10 0 SHEET 2 AA7 7 TYR D 32 GLN D 39 0 SHEET 3 AA7 7 LEU D 45 TRP D 52 -1 O GLU D 46 N ARG D 38 SHEET 4 AA7 7 LYS D 55 ALA D 58 -1 O SER D 57 N GLN D 50 SHEET 5 AA7 7 ALA D 94 SER D 102 -1 O VAL D 95 N GLN D 39 SHEET 6 AA7 7 SER D 120 TRP D 121 -1 O SER D 120 N THR D 100 SHEET 7 AA7 7 THR D 125 SER D 128 -1 O ILE D 127 N ALA D 94 SHEET 1 AA8 2 HIS D 111 HIS D 112 0 SHEET 2 AA8 2 VAL D 115 MET D 116 -1 O VAL D 115 N HIS D 112 SHEET 1 AA9 4 MET E 3 GLN E 5 0 SHEET 2 AA9 4 THR E 17 ALA E 24 -1 O ARG E 23 N THR E 4 SHEET 3 AA9 4 ASP E 70 GLY E 76 -1 O PHE E 71 N CYS E 22 SHEET 4 AA9 4 PHE E 62 ALA E 67 -1 N SER E 65 O THR E 72 SHEET 1 AB1 7 THR E 9 LEU E 10 0 SHEET 2 AB1 7 VAL E 33 GLN E 38 0 SHEET 3 AB1 7 ARG E 45 TYR E 49 -1 O ARG E 45 N GLN E 37 SHEET 4 AB1 7 ALA E 53 LEU E 54 -1 O ALA E 53 N TYR E 49 SHEET 5 AB1 7 GLY E 84 GLN E 90 -1 O GLN E 89 N ALA E 34 SHEET 6 AB1 7 THR E 97 PHE E 98 -1 O THR E 97 N GLN E 90 SHEET 7 AB1 7 THR E 102 VAL E 104 -1 O THR E 102 N PHE E 86 SHEET 1 AB2 4 HIS H 2 GLN H 5 0 SHEET 2 AB2 4 VAL H 17 TYR H 24 -1 O LYS H 22 N VAL H 4 SHEET 3 AB2 4 ILE H 80 ILE H 85 -1 O ILE H 85 N VAL H 17 SHEET 4 AB2 4 VAL H 66 VAL H 71 -1 N SER H 69 O SER H 82 SHEET 1 AB3 7 GLU H 9 VAL H 10 0 SHEET 2 AB3 7 TYR H 32 GLN H 39 0 SHEET 3 AB3 7 LEU H 45 TRP H 52 -1 O GLU H 46 N ARG H 38 SHEET 4 AB3 7 LYS H 55 ALA H 58 -1 O SER H 57 N GLN H 50 SHEET 5 AB3 7 ALA H 94 SER H 102 -1 O THR H 101 N ALA H 33 SHEET 6 AB3 7 SER H 120 TRP H 121 -1 O SER H 120 N THR H 100 SHEET 7 AB3 7 THR H 125 SER H 128 -1 O ILE H 127 N ALA H 94 SHEET 1 AB4 2 HIS H 111 HIS H 112 0 SHEET 2 AB4 2 VAL H 115 MET H 116 -1 O VAL H 115 N HIS H 112 SHEET 1 AB5 4 MET L 3 GLN L 5 0 SHEET 2 AB5 4 VAL L 18 ALA L 24 -1 O ARG L 23 N THR L 4 SHEET 3 AB5 4 ASP L 70 ILE L 75 -1 O PHE L 71 N CYS L 22 SHEET 4 AB5 4 PHE L 62 ALA L 67 -1 N SER L 65 O THR L 72 SHEET 1 AB6 5 VAL L 33 GLN L 38 0 SHEET 2 AB6 5 ARG L 45 ILE L 48 -1 O ARG L 45 N GLN L 37 SHEET 3 AB6 5 GLY L 84 GLN L 90 -1 O GLN L 89 N ALA L 34 SHEET 4 AB6 5 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 5 AB6 5 THR L 102 VAL L 104 -1 O THR L 102 N PHE L 86 SHEET 1 AB7 3 ILE R 603 PRO R 609 0 SHEET 2 AB7 3 TRP X 35 TYR X 40 -1 O VAL X 38 N CYS R 604 SHEET 3 AB7 3 LEU X 494 THR X 499 -1 O THR X 499 N TRP X 35 SHEET 1 AB8 3 ILE S 603 PRO S 609 0 SHEET 2 AB8 3 TRP Y 35 TYR Y 39 -1 O VAL Y 38 N CYS S 604 SHEET 3 AB8 3 GLY Y 495 THR Y 499 -1 O THR Y 499 N TRP Y 35 SHEET 1 AB9 3 ILE T 603 PRO T 609 0 SHEET 2 AB9 3 TRP Z 35 TYR Z 40 -1 O VAL Z 38 N CYS T 604 SHEET 3 AB9 3 LEU Z 494 THR Z 499 -1 O GLY Z 495 N TYR Z 39 SHEET 1 AC1 5 TRP X 45 ASP X 47 0 SHEET 2 AC1 5 TYR X 486 ILE X 491 -1 O GLN X 490 N ARG X 46 SHEET 3 AC1 5 TYR X 223 CYS X 228 -1 N ALA X 224 O VAL X 489 SHEET 4 AC1 5 VAL X 242 VAL X 245 -1 O SER X 243 N LYS X 227 SHEET 5 AC1 5 ILE X 84 LEU X 86 -1 N LEU X 86 O VAL X 242 SHEET 1 AC2 2 PHE X 53 ALA X 55 0 SHEET 2 AC2 2 HIS X 216 CYS X 218 -1 O HIS X 216 N ALA X 55 SHEET 1 AC3 2 GLU X 91 ASN X 94 0 SHEET 2 AC3 2 THR X 236 CYS X 239 -1 O GLY X 237 N PHE X 93 SHEET 1 AC4 5 GLN X 169 TYR X 177 0 SHEET 2 AC4 5 VAL X 154 THR X 162 -1 N CYS X 157 O ALA X 174 SHEET 3 AC4 5 LEU X 129 LYS X 133 -1 N ASN X 130 O THR X 158 SHEET 4 AC4 5 GLU X 190 LEU X 193 -1 O TYR X 191 N LEU X 129 SHEET 5 AC4 5 ILE X 181 GLN X 183 -1 N VAL X 182 O ARG X 192 SHEET 1 AC5 3 ILE X 201 GLN X 203 0 SHEET 2 AC5 3 ALA X 433 TYR X 435 1 O TYR X 435 N LYS X 202 SHEET 3 AC5 3 ILE X 423 VAL X 424 -1 N VAL X 424 O MET X 434 SHEET 1 AC610 LEU X 259 LEU X 261 0 SHEET 2 AC610 ILE X 271 ARG X 273 0 SHEET 3 AC610 ILE X 284 ARG X 298 -1 O HIS X 287 N ILE X 271 SHEET 4 AC610 TYR X 330 ASN X 334 -1 O TYR X 330 N THR X 297 SHEET 5 AC610 THR X 358 PHE X 361 0 SHEET 6 AC610 HIS X 374 CYS X 378 0 SHEET 7 AC610 GLU X 381 CYS X 385 -1 O CYS X 385 N HIS X 374 SHEET 8 AC610 THR X 413 LYS X 421 -1 O ARG X 419 N TYR X 384 SHEET 9 AC610 ILE X 443 ARG X 456 -1 O ILE X 452 N VAL X 286 SHEET 10 AC610 ASP X 465 PRO X 470 -1 O ARG X 469 N THR X 455 SHEET 1 AC7 2 ASN X 302 GLY X 312 0 SHEET 2 AC7 2 GLN X 315 ILE X 322 -1 O ARG X 319 N THR X 305 SHEET 1 AC8 5 TRP Y 45 ASP Y 47 0 SHEET 2 AC8 5 TYR Y 486 ILE Y 491 -1 O GLN Y 490 N ARG Y 46 SHEET 3 AC8 5 TYR Y 223 CYS Y 228 -1 N ALA Y 224 O VAL Y 489 SHEET 4 AC8 5 VAL Y 242 VAL Y 245 -1 O SER Y 243 N LYS Y 227 SHEET 5 AC8 5 ILE Y 84 LEU Y 86 -1 N LEU Y 86 O VAL Y 242 SHEET 1 AC9 2 PHE Y 53 ALA Y 55 0 SHEET 2 AC9 2 HIS Y 216 CYS Y 218 -1 O HIS Y 216 N ALA Y 55 SHEET 1 AD1 2 GLU Y 91 ASN Y 94 0 SHEET 2 AD1 2 THR Y 236 CYS Y 239 -1 O GLY Y 237 N PHE Y 93 SHEET 1 AD2 5 GLN Y 169 TYR Y 177 0 SHEET 2 AD2 5 VAL Y 154 THR Y 162 -1 N CYS Y 157 O ALA Y 174 SHEET 3 AD2 5 LEU Y 129 LYS Y 133 -1 N ASN Y 130 O THR Y 158 SHEET 4 AD2 5 GLU Y 190 LEU Y 193 -1 O TYR Y 191 N LEU Y 129 SHEET 5 AD2 5 ILE Y 181 GLN Y 183 -1 N VAL Y 182 O ARG Y 192 SHEET 1 AD3 3 LYS Y 202 GLN Y 203 0 SHEET 2 AD3 3 MET Y 434 TYR Y 435 1 O TYR Y 435 N LYS Y 202 SHEET 3 AD3 3 ILE Y 423 VAL Y 424 -1 N VAL Y 424 O MET Y 434 SHEET 1 AD410 LEU Y 259 LEU Y 261 0 SHEET 2 AD410 ILE Y 271 ARG Y 273 0 SHEET 3 AD410 ILE Y 284 ARG Y 298 -1 O ILE Y 285 N ARG Y 273 SHEET 4 AD410 ALA Y 329 ASN Y 334 -1 O GLU Y 332 N SER Y 295 SHEET 5 AD410 THR Y 358 PHE Y 361 0 SHEET 6 AD410 HIS Y 374 CYS Y 378 0 SHEET 7 AD410 GLU Y 381 CYS Y 385 -1 O CYS Y 385 N HIS Y 374 SHEET 8 AD410 THR Y 413 LYS Y 421 -1 O ARG Y 419 N TYR Y 384 SHEET 9 AD410 ILE Y 443 ARG Y 456 -1 O ILE Y 449 N VAL Y 292 SHEET 10 AD410 ASP Y 465 PRO Y 470 -1 O ARG Y 469 N THR Y 455 SHEET 1 AD5 2 ARG Y 304 ARG Y 308 0 SHEET 2 AD5 2 MET Y 316 THR Y 320 -1 O PHE Y 317 N ILE Y 307 SHEET 1 AD6 5 TRP Z 45 ASP Z 47 0 SHEET 2 AD6 5 TYR Z 486 ILE Z 491 -1 O GLN Z 490 N ARG Z 46 SHEET 3 AD6 5 TYR Z 223 CYS Z 228 -1 N ALA Z 224 O VAL Z 489 SHEET 4 AD6 5 VAL Z 242 VAL Z 245 -1 O SER Z 243 N LYS Z 227 SHEET 5 AD6 5 ILE Z 84 LEU Z 86 -1 N ILE Z 84 O THR Z 244 SHEET 1 AD7 2 PHE Z 53 ALA Z 55 0 SHEET 2 AD7 2 HIS Z 216 CYS Z 218 -1 O HIS Z 216 N ALA Z 55 SHEET 1 AD8 2 GLU Z 91 ASN Z 94 0 SHEET 2 AD8 2 THR Z 236 CYS Z 239 -1 O GLY Z 237 N PHE Z 93 SHEET 1 AD9 4 VAL Z 120 LYS Z 121 0 SHEET 2 AD9 4 LYS Z 202 GLN Z 203 -1 O GLN Z 203 N VAL Z 120 SHEET 3 AD9 4 MET Z 434 TYR Z 435 1 O TYR Z 435 N LYS Z 202 SHEET 4 AD9 4 ILE Z 423 VAL Z 424 -1 N VAL Z 424 O MET Z 434 SHEET 1 AE1 5 GLN Z 169 TYR Z 177 0 SHEET 2 AE1 5 VAL Z 154 THR Z 162 -1 N CYS Z 157 O ALA Z 174 SHEET 3 AE1 5 LEU Z 129 LYS Z 133 -1 N ASN Z 130 O THR Z 158 SHEET 4 AE1 5 GLU Z 190 LEU Z 193 -1 O TYR Z 191 N LEU Z 129 SHEET 5 AE1 5 ILE Z 181 GLN Z 183 -1 N VAL Z 182 O ARG Z 192 SHEET 1 AE211 LEU Z 259 LEU Z 261 0 SHEET 2 AE211 ILE Z 271 ARG Z 273 0 SHEET 3 AE211 ILE Z 284 GLY Z 312 -1 O HIS Z 287 N ILE Z 271 SHEET 4 AE211 GLN Z 315 GLY Z 324 -1 O GLY Z 320A N THR Z 303 SHEET 5 AE211 TYR Z 330 ASN Z 334 -1 O TYR Z 330 N THR Z 297 SHEET 6 AE211 THR Z 358 PHE Z 361 0 SHEET 7 AE211 HIS Z 374 CYS Z 378 0 SHEET 8 AE211 GLU Z 381 CYS Z 385 -1 O CYS Z 385 N HIS Z 374 SHEET 9 AE211 THR Z 413 LYS Z 421 -1 O LYS Z 421 N PHE Z 382 SHEET 10 AE211 GLY Z 441 ARG Z 456 -1 O ILE Z 452 N VAL Z 286 SHEET 11 AE211 ASP Z 465 PRO Z 470 -1 O ARG Z 469 N THR Z 455 SSBOND 1 CYS A 21 CYS A 98 1555 1555 2.03 SSBOND 2 CYS C 22 CYS C 88 1555 1555 2.04 SSBOND 3 CYS D 21 CYS D 98 1555 1555 2.03 SSBOND 4 CYS E 22 CYS E 88 1555 1555 2.03 SSBOND 5 CYS H 21 CYS H 98 1555 1555 2.04 SSBOND 6 CYS L 22 CYS L 88 1555 1555 2.03 SSBOND 7 CYS R 598 CYS R 604 1555 1555 2.03 SSBOND 8 CYS R 605 CYS X 501 1555 1555 2.03 SSBOND 9 CYS S 598 CYS S 604 1555 1555 2.03 SSBOND 10 CYS S 605 CYS Y 501 1555 1555 2.03 SSBOND 11 CYS T 598 CYS T 604 1555 1555 2.03 SSBOND 12 CYS T 605 CYS Z 501 1555 1555 2.03 SSBOND 13 CYS X 54 CYS X 74 1555 1555 2.03 SSBOND 14 CYS X 119 CYS X 205 1555 1555 2.03 SSBOND 15 CYS X 126 CYS X 196 1555 1555 2.03 SSBOND 16 CYS X 131 CYS X 157 1555 1555 2.03 SSBOND 17 CYS X 218 CYS X 247 1555 1555 2.05 SSBOND 18 CYS X 228 CYS X 239 1555 1555 2.03 SSBOND 19 CYS X 296 CYS X 331 1555 1555 2.03 SSBOND 20 CYS X 378 CYS X 445 1555 1555 2.03 SSBOND 21 CYS X 385 CYS X 418 1555 1555 2.03 SSBOND 22 CYS Y 54 CYS Y 74 1555 1555 2.03 SSBOND 23 CYS Y 119 CYS Y 205 1555 1555 2.03 SSBOND 24 CYS Y 126 CYS Y 196 1555 1555 2.03 SSBOND 25 CYS Y 131 CYS Y 157 1555 1555 2.03 SSBOND 26 CYS Y 218 CYS Y 247 1555 1555 2.03 SSBOND 27 CYS Y 228 CYS Y 239 1555 1555 2.03 SSBOND 28 CYS Y 296 CYS Y 331 1555 1555 2.03 SSBOND 29 CYS Y 378 CYS Y 445 1555 1555 2.03 SSBOND 30 CYS Y 385 CYS Y 418 1555 1555 2.03 SSBOND 31 CYS Z 54 CYS Z 74 1555 1555 2.03 SSBOND 32 CYS Z 126 CYS Z 196 1555 1555 2.03 SSBOND 33 CYS Z 131 CYS Z 157 1555 1555 2.03 SSBOND 34 CYS Z 218 CYS Z 247 1555 1555 2.05 SSBOND 35 CYS Z 228 CYS Z 239 1555 1555 2.03 SSBOND 36 CYS Z 296 CYS Z 331 1555 1555 2.03 SSBOND 37 CYS Z 378 CYS Z 445 1555 1555 2.03 SSBOND 38 CYS Z 385 CYS Z 418 1555 1555 2.03 LINK ND2 ASN R 611 C1 NAG R 701 1555 1555 1.44 LINK ND2 ASN R 637 C1 NAG B 1 1555 1555 1.44 LINK ND2 ASN S 611 C1 NAG S 701 1555 1555 1.44 LINK ND2 ASN S 637 C1 NAG F 1 1555 1555 1.44 LINK ND2 ASN T 611 C1 NAG T 701 1555 1555 1.44 LINK ND2 ASN T 637 C1 NAG G 1 1555 1555 1.43 LINK ND2 ASN X 88 C1 NAG X 701 1555 1555 1.44 LINK ND2 ASN X 130 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN X 135 C1 NAG X 702 1555 1555 1.44 LINK ND2 ASN X 149 C1 NAG X 703 1555 1555 1.44 LINK ND2 ASN X 156 C1 NAG I 1 1555 1555 1.44 LINK ND2 ASN X 160 C1 NAG X 704 1555 1555 1.43 LINK ND2 ASN X 197 C1 NAG J 1 1555 1555 1.44 LINK ND2 ASN X 234 C1 NAG K 1 1555 1555 1.43 LINK ND2 ASN X 241 C1 NAG X 705 1555 1555 1.44 LINK ND2 ASN X 262 C1 NAG M 1 1555 1555 1.43 LINK ND2 ASN X 276 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN X 289 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN X 301 C1 NAG X 707 1555 1555 1.44 LINK ND2 ASN X 334 C1 NAG X 708 1555 1555 1.44 LINK ND2 ASN X 339 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN X 386 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN X 444 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN X 448 C1 NAG X 706 1555 1555 1.44 LINK ND2 ASN Y 88 C1 NAG Y 701 1555 1555 1.44 LINK ND2 ASN Y 130 C1 NAG h 1 1555 1555 1.44 LINK ND2 ASN Y 135 C1 NAG Y 702 1555 1555 1.44 LINK ND2 ASN Y 149 C1 NAG Y 703 1555 1555 1.44 LINK ND2 ASN Y 156 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN Y 160 C1 NAG Y 704 1555 1555 1.44 LINK ND2 ASN Y 197 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN Y 234 C1 NAG b 1 1555 1555 1.43 LINK ND2 ASN Y 241 C1 NAG Y 705 1555 1555 1.44 LINK ND2 ASN Y 262 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN Y 276 C1 NAG d 1 1555 1555 1.43 LINK ND2 ASN Y 289 C1 NAG e 1 1555 1555 1.44 LINK ND2 ASN Y 301 C1 NAG Y 706 1555 1555 1.44 LINK ND2 ASN Y 334 C1 NAG Y 707 1555 1555 1.44 LINK ND2 ASN Y 339 C1 NAG Y 708 1555 1555 1.44 LINK ND2 ASN Y 386 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN Y 444 C1 NAG g 1 1555 1555 1.44 LINK ND2 ASN Y 448 C1 NAG Y 709 1555 1555 1.44 LINK ND2 ASN Z 88 C1 NAG Z 701 1555 1555 1.44 LINK ND2 ASN Z 130 C1 NAG r 1 1555 1555 1.44 LINK ND2 ASN Z 135 C1 NAG Z 702 1555 1555 1.44 LINK ND2 ASN Z 149 C1 NAG Z 703 1555 1555 1.44 LINK ND2 ASN Z 156 C1 NAG i 1 1555 1555 1.44 LINK ND2 ASN Z 160 C1 NAG Z 704 1555 1555 1.44 LINK ND2 ASN Z 197 C1 NAG j 1 1555 1555 1.44 LINK ND2 ASN Z 234 C1 NAG k 1 1555 1555 1.43 LINK ND2 ASN Z 241 C1 NAG Z 705 1555 1555 1.44 LINK ND2 ASN Z 262 C1 NAG l 1 1555 1555 1.44 LINK ND2 ASN Z 276 C1 NAG m 1 1555 1555 1.44 LINK ND2 ASN Z 289 C1 NAG n 1 1555 1555 1.44 LINK ND2 ASN Z 301 C1 NAG Z 707 1555 1555 1.44 LINK ND2 ASN Z 334 C1 NAG Z 708 1555 1555 1.44 LINK ND2 ASN Z 339 C1 NAG o 1 1555 1555 1.44 LINK ND2 ASN Z 356 C1 NAG Z 709 1555 1555 1.44 LINK ND2 ASN Z 386 C1 NAG p 1 1555 1555 1.44 LINK ND2 ASN Z 444 C1 NAG q 1 1555 1555 1.44 LINK ND2 ASN Z 448 C1 NAG Z 706 1555 1555 1.43 LINK O4 NAG B 1 C1 NAG B 2 1555 1555 1.44 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.45 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.43 LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.45 LINK O3 BMA K 3 C1 MAN K 4 1555 1555 1.44 LINK O6 BMA K 3 C1 MAN K 7 1555 1555 1.44 LINK O2 MAN K 4 C1 MAN K 5 1555 1555 1.44 LINK O2 MAN K 5 C1 MAN K 6 1555 1555 1.44 LINK O3 MAN K 7 C1 MAN K 8 1555 1555 1.44 LINK O6 MAN K 7 C1 MAN K 10 1555 1555 1.44 LINK O2 MAN K 8 C1 MAN K 9 1555 1555 1.44 LINK O2 MAN K 10 C1 MAN K 11 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.45 LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.44 LINK O3 BMA M 3 C1 MAN M 4 1555 1555 1.44 LINK O6 BMA M 3 C1 MAN M 5 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.44 LINK O4 NAG b 2 C1 BMA b 3 1555 1555 1.45 LINK O3 BMA b 3 C1 MAN b 4 1555 1555 1.44 LINK O6 BMA b 3 C1 MAN b 7 1555 1555 1.44 LINK O2 MAN b 4 C1 MAN b 5 1555 1555 1.44 LINK O2 MAN b 5 C1 MAN b 6 1555 1555 1.44 LINK O3 MAN b 7 C1 MAN b 8 1555 1555 1.44 LINK O6 MAN b 7 C1 MAN b 10 1555 1555 1.44 LINK O2 MAN b 8 C1 MAN b 9 1555 1555 1.44 LINK O2 MAN b 10 C1 MAN b 11 1555 1555 1.44 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.45 LINK O4 NAG c 2 C1 BMA c 3 1555 1555 1.44 LINK O3 BMA c 3 C1 MAN c 4 1555 1555 1.44 LINK O6 BMA c 3 C1 MAN c 5 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.44 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.45 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.44 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.44 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.45 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.44 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.44 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.44 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.43 LINK O4 NAG k 2 C1 BMA k 3 1555 1555 1.45 LINK O3 BMA k 3 C1 MAN k 4 1555 1555 1.44 LINK O6 BMA k 3 C1 MAN k 7 1555 1555 1.44 LINK O2 MAN k 4 C1 MAN k 5 1555 1555 1.44 LINK O2 MAN k 5 C1 MAN k 6 1555 1555 1.44 LINK O3 MAN k 7 C1 MAN k 8 1555 1555 1.44 LINK O6 MAN k 7 C1 MAN k 10 1555 1555 1.44 LINK O2 MAN k 8 C1 MAN k 9 1555 1555 1.44 LINK O2 MAN k 10 C1 MAN k 11 1555 1555 1.44 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.45 LINK O4 NAG l 2 C1 BMA l 3 1555 1555 1.44 LINK O3 BMA l 3 C1 MAN l 4 1555 1555 1.44 LINK O6 BMA l 3 C1 MAN l 5 1555 1555 1.44 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.44 LINK O4 NAG m 2 C1 BMA m 3 1555 1555 1.45 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.44 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.44 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.44 LINK O4 NAG q 1 C1 NAG q 2 1555 1555 1.45 LINK O4 NAG r 1 C1 NAG r 2 1555 1555 1.44 CISPEP 1 TYR C 94 PRO C 95 0 -0.35 CISPEP 2 TYR E 94 PRO E 95 0 -7.12 CISPEP 3 TYR L 94 PRO L 95 0 -3.79 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000