HEADER IMMUNE SYSTEM/VIRAL PROTEIN 12-DEC-22 8HPQ TITLE CRYO-EM STRUCTURE OF SARS-COV-2 OMICRON BA.4 S-TRIMER IN COMPLEX WITH TITLE 2 FAB L4.65 AND L5.34 CAVEAT 8HPQ THERE ARE POLYMER GEOMETRY AND LINKAGE ERRORS COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE PROTEIN S2'; COMPND 3 CHAIN: A, B, C; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: FAB L4.65; COMPND 7 CHAIN: H, P, I; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: FAB L4.65; COMPND 11 CHAIN: L, Q, J; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: FAB L5.34; COMPND 15 CHAIN: M, E, R; COMPND 16 ENGINEERED: YES; COMPND 17 MOL_ID: 5; COMPND 18 MOLECULE: FAB L5.34; COMPND 19 CHAIN: N, F, S; COMPND 20 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_COMMON: 2019NCOV, SARS-COV-2; SOURCE 5 ORGANISM_TAXID: 2697049; SOURCE 6 STRAIN: OMICRON/BA.4; SOURCE 7 GENE: S, 2; SOURCE 8 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 9 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 10 MOL_ID: 2; SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 12 ORGANISM_TAXID: 9606; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_TAXID: 9606; SOURCE 18 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 20 MOL_ID: 4; SOURCE 21 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 22 ORGANISM_TAXID: 9606; SOURCE 23 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 24 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 25 MOL_ID: 5; SOURCE 26 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 27 ORGANISM_TAXID: 9606; SOURCE 28 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 29 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS SARS-COV-2, OMICRON BA.4 S-TRIMER, CRYO-EM STRUCTURE, FAB, IMMUNE KEYWDS 2 SYSTEM/VIRAL PROTEIN, IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.F.GAO,S.LIU REVDAT 1 31-JAN-24 8HPQ 0 JRNL AUTH S.GUO,Y.ZHENG,Z.GAO,M.DUAN,S.LIU,P.DU,X.XU,K.XU,X.ZHAO, JRNL AUTH 2 Y.CHAI,P.WANG,Q.ZHAO,G.F.GAO,L.DAI JRNL TITL DOSING INTERVAL REGIMEN SHAPES POTENCY AND BREADTH OF JRNL TITL 2 ANTIBODY REPERTOIRE AFTER VACCINATION OF SARS-COV-2 RBD JRNL TITL 3 PROTEIN SUBUNIT VACCINE. JRNL REF CELL DISCOV V. 9 79 2023 JRNL REFN ESSN 2056-5968 JRNL PMID 37507370 JRNL DOI 10.1038/S41421-023-00585-5 REMARK 2 REMARK 2 RESOLUTION. 2.85 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.850 REMARK 3 NUMBER OF PARTICLES : 593563 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8HPQ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 21-DEC-22. REMARK 100 THE DEPOSITION ID IS D_1300034099. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF SARS-COV-2 REMARK 245 OMICRON BA.4 S-TRIMER IN REMARK 245 COMPLEX WITH FAB L4.65 AND L5.34 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1200.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 5000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 139.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, H, L, M, N, B, P, Q, E, F, REMARK 350 AND CHAINS: C, I, J, R, S REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER A 85 REMARK 465 GLY A 86 REMARK 465 THR A 87 REMARK 465 ASN A 88 REMARK 465 GLY A 89 REMARK 465 THR A 90 REMARK 465 VAL A 157 REMARK 465 TYR A 158 REMARK 465 TYR A 159 REMARK 465 HIS A 160 REMARK 465 LYS A 161 REMARK 465 ASN A 162 REMARK 465 ASN A 163 REMARK 465 LYS A 164 REMARK 465 SER A 165 REMARK 465 TRP A 166 REMARK 465 MET A 191 REMARK 465 ASP A 192 REMARK 465 LEU A 193 REMARK 465 GLU A 194 REMARK 465 GLY A 195 REMARK 465 LYS A 196 REMARK 465 GLN A 197 REMARK 465 GLY A 198 REMARK 465 ASN A 225 REMARK 465 LEU A 226 REMARK 465 VAL A 227 REMARK 465 ARG A 228 REMARK 465 TYR A 262 REMARK 465 LEU A 263 REMARK 465 THR A 264 REMARK 465 PRO A 265 REMARK 465 GLY A 266 REMARK 465 ASP A 267 REMARK 465 SER A 268 REMARK 465 SER A 269 REMARK 465 SER A 270 REMARK 465 PRO A 635 REMARK 465 VAL A 636 REMARK 465 ALA A 637 REMARK 465 ILE A 638 REMARK 465 HIS A 639 REMARK 465 ALA A 640 REMARK 465 ASP A 641 REMARK 465 GLN A 642 REMARK 465 LEU A 643 REMARK 465 THR A 644 REMARK 465 PRO A 645 REMARK 465 THR A 646 REMARK 465 TRP A 647 REMARK 465 ARG A 648 REMARK 465 VAL A 649 REMARK 465 TYR A 650 REMARK 465 SER A 651 REMARK 465 THR A 652 REMARK 465 GLY A 653 REMARK 465 SER A 654 REMARK 465 THR A 690 REMARK 465 GLN A 691 REMARK 465 THR A 692 REMARK 465 ASN A 693 REMARK 465 SER A 694 REMARK 465 PRO A 695 REMARK 465 ARG A 696 REMARK 465 ARG A 697 REMARK 465 ALA A 698 REMARK 465 ARG A 699 REMARK 465 SER A 700 REMARK 465 VAL A 701 REMARK 465 ALA A 702 REMARK 465 SER A 703 REMARK 465 GLN A 704 REMARK 465 LEU A 842 REMARK 465 ALA A 843 REMARK 465 ASP A 844 REMARK 465 ALA A 845 REMARK 465 GLY A 846 REMARK 465 PHE A 847 REMARK 465 ILE A 848 REMARK 465 LYS A 849 REMARK 465 GLN A 850 REMARK 465 TYR A 851 REMARK 465 GLY A 852 REMARK 465 ASP A 853 REMARK 465 CYS A 854 REMARK 465 LEU A 855 REMARK 465 GLY A 856 REMARK 465 ASP A 857 REMARK 465 ILE A 858 REMARK 465 ALA A 859 REMARK 465 ALA A 860 REMARK 465 ARG A 861 REMARK 465 ASP A 862 REMARK 465 LEU A 863 REMARK 465 ILE A 864 REMARK 465 CYS A 865 REMARK 465 ALA A 866 REMARK 465 GLN A 867 REMARK 465 LYS A 868 REMARK 465 PHE A 869 REMARK 465 SER B 85 REMARK 465 GLY B 86 REMARK 465 THR B 87 REMARK 465 ASN B 88 REMARK 465 GLY B 89 REMARK 465 THR B 90 REMARK 465 VAL B 157 REMARK 465 TYR B 158 REMARK 465 TYR B 159 REMARK 465 HIS B 160 REMARK 465 LYS B 161 REMARK 465 ASN B 162 REMARK 465 ASN B 163 REMARK 465 LYS B 164 REMARK 465 SER B 165 REMARK 465 TRP B 166 REMARK 465 MET B 191 REMARK 465 ASP B 192 REMARK 465 LEU B 193 REMARK 465 GLU B 194 REMARK 465 GLY B 195 REMARK 465 LYS B 196 REMARK 465 GLN B 197 REMARK 465 GLY B 198 REMARK 465 ASN B 225 REMARK 465 LEU B 226 REMARK 465 VAL B 227 REMARK 465 ARG B 228 REMARK 465 TYR B 262 REMARK 465 LEU B 263 REMARK 465 THR B 264 REMARK 465 PRO B 265 REMARK 465 GLY B 266 REMARK 465 ASP B 267 REMARK 465 SER B 268 REMARK 465 SER B 269 REMARK 465 SER B 270 REMARK 465 PRO B 635 REMARK 465 VAL B 636 REMARK 465 ALA B 637 REMARK 465 ILE B 638 REMARK 465 HIS B 639 REMARK 465 ALA B 640 REMARK 465 ASP B 641 REMARK 465 GLN B 642 REMARK 465 LEU B 643 REMARK 465 THR B 644 REMARK 465 PRO B 645 REMARK 465 THR B 646 REMARK 465 TRP B 647 REMARK 465 ARG B 648 REMARK 465 VAL B 649 REMARK 465 TYR B 650 REMARK 465 SER B 651 REMARK 465 THR B 652 REMARK 465 GLY B 653 REMARK 465 SER B 654 REMARK 465 THR B 690 REMARK 465 GLN B 691 REMARK 465 THR B 692 REMARK 465 ASN B 693 REMARK 465 SER B 694 REMARK 465 PRO B 695 REMARK 465 ARG B 696 REMARK 465 ARG B 697 REMARK 465 ALA B 698 REMARK 465 ARG B 699 REMARK 465 SER B 700 REMARK 465 VAL B 701 REMARK 465 ALA B 702 REMARK 465 SER B 703 REMARK 465 GLN B 704 REMARK 465 LEU B 842 REMARK 465 ALA B 843 REMARK 465 ASP B 844 REMARK 465 ALA B 845 REMARK 465 GLY B 846 REMARK 465 PHE B 847 REMARK 465 ILE B 848 REMARK 465 LYS B 849 REMARK 465 GLN B 850 REMARK 465 TYR B 851 REMARK 465 GLY B 852 REMARK 465 ASP B 853 REMARK 465 CYS B 854 REMARK 465 LEU B 855 REMARK 465 GLY B 856 REMARK 465 ASP B 857 REMARK 465 ILE B 858 REMARK 465 ALA B 859 REMARK 465 ALA B 860 REMARK 465 ARG B 861 REMARK 465 ASP B 862 REMARK 465 LEU B 863 REMARK 465 ILE B 864 REMARK 465 CYS B 865 REMARK 465 ALA B 866 REMARK 465 GLN B 867 REMARK 465 LYS B 868 REMARK 465 PHE B 869 REMARK 465 SER C 85 REMARK 465 GLY C 86 REMARK 465 THR C 87 REMARK 465 ASN C 88 REMARK 465 GLY C 89 REMARK 465 THR C 90 REMARK 465 VAL C 157 REMARK 465 TYR C 158 REMARK 465 TYR C 159 REMARK 465 HIS C 160 REMARK 465 LYS C 161 REMARK 465 ASN C 162 REMARK 465 ASN C 163 REMARK 465 LYS C 164 REMARK 465 SER C 165 REMARK 465 TRP C 166 REMARK 465 MET C 191 REMARK 465 ASP C 192 REMARK 465 LEU C 193 REMARK 465 GLU C 194 REMARK 465 GLY C 195 REMARK 465 LYS C 196 REMARK 465 GLN C 197 REMARK 465 GLY C 198 REMARK 465 ASN C 225 REMARK 465 LEU C 226 REMARK 465 VAL C 227 REMARK 465 ARG C 228 REMARK 465 TYR C 262 REMARK 465 LEU C 263 REMARK 465 THR C 264 REMARK 465 PRO C 265 REMARK 465 GLY C 266 REMARK 465 ASP C 267 REMARK 465 SER C 268 REMARK 465 SER C 269 REMARK 465 SER C 270 REMARK 465 PRO C 635 REMARK 465 VAL C 636 REMARK 465 ALA C 637 REMARK 465 ILE C 638 REMARK 465 HIS C 639 REMARK 465 ALA C 640 REMARK 465 ASP C 641 REMARK 465 GLN C 642 REMARK 465 LEU C 643 REMARK 465 THR C 644 REMARK 465 PRO C 645 REMARK 465 THR C 646 REMARK 465 TRP C 647 REMARK 465 ARG C 648 REMARK 465 VAL C 649 REMARK 465 TYR C 650 REMARK 465 SER C 651 REMARK 465 THR C 652 REMARK 465 GLY C 653 REMARK 465 SER C 654 REMARK 465 THR C 690 REMARK 465 GLN C 691 REMARK 465 THR C 692 REMARK 465 ASN C 693 REMARK 465 SER C 694 REMARK 465 PRO C 695 REMARK 465 ARG C 696 REMARK 465 ARG C 697 REMARK 465 ALA C 698 REMARK 465 ARG C 699 REMARK 465 SER C 700 REMARK 465 VAL C 701 REMARK 465 ALA C 702 REMARK 465 SER C 703 REMARK 465 GLN C 704 REMARK 465 LEU C 842 REMARK 465 ALA C 843 REMARK 465 ASP C 844 REMARK 465 ALA C 845 REMARK 465 GLY C 846 REMARK 465 PHE C 847 REMARK 465 ILE C 848 REMARK 465 LYS C 849 REMARK 465 GLN C 850 REMARK 465 TYR C 851 REMARK 465 GLY C 852 REMARK 465 ASP C 853 REMARK 465 CYS C 854 REMARK 465 LEU C 855 REMARK 465 GLY C 856 REMARK 465 ASP C 857 REMARK 465 ILE C 858 REMARK 465 ALA C 859 REMARK 465 ALA C 860 REMARK 465 ARG C 861 REMARK 465 ASP C 862 REMARK 465 LEU C 863 REMARK 465 ILE C 864 REMARK 465 CYS C 865 REMARK 465 ALA C 866 REMARK 465 GLN C 867 REMARK 465 LYS C 868 REMARK 465 PHE C 869 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ILE A 38 CG2 CD1 REMARK 470 THR A 109 CG2 REMARK 470 ASN A 199 OD1 ND2 REMARK 470 THR A 561 CG2 REMARK 470 ASN A 870 OD1 ND2 REMARK 470 LEU A 995 CD1 CD2 REMARK 470 ILE B 38 CG2 CD1 REMARK 470 THR B 109 CG2 REMARK 470 ASN B 199 OD1 ND2 REMARK 470 THR B 561 CG2 REMARK 470 ASN B 870 OD1 ND2 REMARK 470 LEU B 995 CD1 CD2 REMARK 470 ILE C 38 CG2 CD1 REMARK 470 THR C 109 CG2 REMARK 470 ASN C 199 OD1 ND2 REMARK 470 THR C 561 CG2 REMARK 470 ASN C 870 OD1 ND2 REMARK 470 LEU C 995 CD1 CD2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 ND2 ASN A 374 CE1 PHE C 182 1.40 REMARK 500 CD1 PHE B 59 OE1 GLN C 577 1.41 REMARK 500 CD1 PHE A 59 OE1 GLN B 577 1.41 REMARK 500 OE1 GLN A 577 CD1 PHE C 59 1.46 REMARK 500 O SER B 605 N PHE B 606 1.57 REMARK 500 CE1 PHE A 182 ND2 ASN B 374 1.66 REMARK 500 CA THR B 181 NH1 ARG C 371 1.67 REMARK 500 O SER C 605 N PHE C 606 1.68 REMARK 500 CE1 PHE B 182 ND2 ASN C 374 1.73 REMARK 500 O SER A 605 N PHE A 606 1.74 REMARK 500 CD1 PHE A 59 CD GLN B 577 1.75 REMARK 500 CD GLN A 577 CD1 PHE C 59 1.77 REMARK 500 CD1 PHE B 59 CD GLN C 577 1.85 REMARK 500 CB THR B 181 NH2 ARG C 371 1.98 REMARK 500 CE1 PHE A 59 OE1 GLN B 577 1.99 REMARK 500 OE1 GLN A 577 CE1 PHE C 59 2.01 REMARK 500 CE1 PHE B 59 OE1 GLN C 577 2.08 REMARK 500 OE1 GLN A 801 ND2 ASN B 717 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 SER A 43 CB SER A 43 OG 0.112 REMARK 500 SER B 43 CB SER B 43 OG 0.112 REMARK 500 SER B 330 CA SER B 330 CB -0.102 REMARK 500 SER C 43 CB SER C 43 OG 0.113 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 THR A 321 CA - C - N ANGL. DEV. = 19.4 DEGREES REMARK 500 THR A 321 O - C - N ANGL. DEV. = -22.5 DEGREES REMARK 500 VAL A 322 C - N - CA ANGL. DEV. = 21.8 DEGREES REMARK 500 ASN A 331 CB - CA - C ANGL. DEV. = 13.3 DEGREES REMARK 500 CYS A 393 CA - CB - SG ANGL. DEV. = 9.1 DEGREES REMARK 500 CYS A 446 CA - CB - SG ANGL. DEV. = 14.1 DEGREES REMARK 500 LYS A 542 CB - CA - C ANGL. DEV. = 17.0 DEGREES REMARK 500 LYS A 542 N - CA - CB ANGL. DEV. = -13.6 DEGREES REMARK 500 ASN A 717 CB - CA - C ANGL. DEV. = -16.4 DEGREES REMARK 500 THR B 321 O - C - N ANGL. DEV. = -14.8 DEGREES REMARK 500 VAL B 322 C - N - CA ANGL. DEV. = 15.3 DEGREES REMARK 500 CYS B 393 CA - CB - SG ANGL. DEV. = 9.1 DEGREES REMARK 500 CYS B 446 CA - CB - SG ANGL. DEV. = 14.1 DEGREES REMARK 500 LYS B 542 CB - CA - C ANGL. DEV. = 13.4 DEGREES REMARK 500 THR C 321 CA - C - N ANGL. DEV. = 22.9 DEGREES REMARK 500 THR C 321 O - C - N ANGL. DEV. = -25.6 DEGREES REMARK 500 VAL C 322 C - N - CA ANGL. DEV. = 24.5 DEGREES REMARK 500 PHE C 332 CB - CA - C ANGL. DEV. = -16.2 DEGREES REMARK 500 CYS C 393 CA - CB - SG ANGL. DEV. = 9.1 DEGREES REMARK 500 CYS C 446 CA - CB - SG ANGL. DEV. = 14.1 DEGREES REMARK 500 LYS C 542 CB - CA - C ANGL. DEV. = 14.8 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PHE A 48 -127.91 59.10 REMARK 500 ASN A 101 -141.05 61.41 REMARK 500 PHE A 332 42.46 -158.51 REMARK 500 THR A 337 -93.37 -72.57 REMARK 500 ASN A 345 95.27 -68.68 REMARK 500 PHE A 391 57.32 -99.30 REMARK 500 TYR A 394 -53.78 -120.92 REMARK 500 ASP A 442 34.96 -94.90 REMARK 500 CYS A 446 -179.38 -171.65 REMARK 500 ASP A 456 31.31 -95.63 REMARK 500 ALA A 489 51.41 -94.87 REMARK 500 ASP A 585 5.30 80.74 REMARK 500 GLN A 594 -38.49 73.17 REMARK 500 ASN A 717 69.73 -155.73 REMARK 500 SER A 718 104.55 -46.37 REMARK 500 ASP H 56 32.45 -96.81 REMARK 500 SER H 106 -6.56 65.05 REMARK 500 TYR H 110 72.19 60.55 REMARK 500 PRO H 117 129.61 -32.93 REMARK 500 ASP H 159 61.31 63.22 REMARK 500 ALA L 52 -9.61 72.24 REMARK 500 PRO L 142 -167.12 -78.30 REMARK 500 SER L 172 12.33 58.26 REMARK 500 GLU M 26 -5.22 69.03 REMARK 500 SER M 122 34.96 -97.34 REMARK 500 SER M 124 71.24 59.77 REMARK 500 THR M 125 129.02 -33.62 REMARK 500 SER N 30 -123.11 55.73 REMARK 500 ALA N 51 -5.20 67.89 REMARK 500 ASN N 140 65.92 60.00 REMARK 500 ASN N 154 -4.86 69.88 REMARK 500 TYR N 188 -30.69 -131.03 REMARK 500 PHE B 48 -127.95 59.12 REMARK 500 ASN B 101 -141.06 61.36 REMARK 500 THR B 329 -62.04 -105.81 REMARK 500 SER B 330 -154.21 -128.99 REMARK 500 ARG B 333 100.23 -168.72 REMARK 500 ASN B 345 95.21 -68.68 REMARK 500 PHE B 391 57.27 -99.24 REMARK 500 TYR B 394 -53.80 -120.91 REMARK 500 ASP B 442 34.95 -94.89 REMARK 500 CYS B 446 -179.45 -171.68 REMARK 500 ASP B 456 31.24 -95.60 REMARK 500 ALA B 489 51.40 -94.82 REMARK 500 ASP B 585 5.29 80.76 REMARK 500 GLN B 594 -38.44 73.12 REMARK 500 GLU B 716 135.56 -21.88 REMARK 500 ASP P 56 32.41 -96.82 REMARK 500 SER P 106 -6.62 65.07 REMARK 500 TYR P 110 72.15 60.51 REMARK 500 REMARK 500 THIS ENTRY HAS 92 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 CYS A 393 TYR A 394 -150.00 REMARK 500 ASP H 116 PRO H 117 -131.43 REMARK 500 CYS B 393 TYR B 394 -149.97 REMARK 500 ASP P 116 PRO P 117 -131.40 REMARK 500 CYS C 393 TYR C 394 -149.97 REMARK 500 ASP I 116 PRO I 117 -131.43 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY REMARK 500 REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME; REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 500 I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI ANGLE REMARK 500 THR A 321 -14.29 REMARK 500 THR B 321 -10.56 REMARK 500 GLY B 540 11.99 REMARK 500 THR C 321 -13.73 REMARK 500 ASN C 331 -13.09 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-34940 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF SARS-COV-2 OMICRON BA.4 S-TRIMER IN COMPLEX REMARK 900 WITH FAB L4.65 AND L5.34 DBREF 8HPQ A 33 1161 UNP P0DTC2 SPIKE_SARS2 14 1147 DBREF 8HPQ H 1 231 PDB 8HPQ 8HPQ 1 231 DBREF 8HPQ L 1 215 PDB 8HPQ 8HPQ 1 215 DBREF 8HPQ M 2 225 PDB 8HPQ 8HPQ 2 225 DBREF 8HPQ N 1 216 PDB 8HPQ 8HPQ 1 216 DBREF 8HPQ B 33 1161 UNP P0DTC2 SPIKE_SARS2 14 1147 DBREF 8HPQ P 1 231 PDB 8HPQ 8HPQ 1 231 DBREF 8HPQ Q 1 215 PDB 8HPQ 8HPQ 1 215 DBREF 8HPQ E 2 225 PDB 8HPQ 8HPQ 2 225 DBREF 8HPQ F 1 216 PDB 8HPQ 8HPQ 1 216 DBREF 8HPQ C 33 1161 UNP P0DTC2 SPIKE_SARS2 14 1147 DBREF 8HPQ I 1 231 PDB 8HPQ 8HPQ 1 231 DBREF 8HPQ J 1 215 PDB 8HPQ 8HPQ 1 215 DBREF 8HPQ R 2 225 PDB 8HPQ 8HPQ 2 225 DBREF 8HPQ S 1 216 PDB 8HPQ 8HPQ 1 216 SEQADV 8HPQ ILE A 38 UNP P0DTC2 THR 19 CONFLICT SEQADV 8HPQ A UNP P0DTC2 LEU 24 DELETION SEQADV 8HPQ A UNP P0DTC2 PRO 25 DELETION SEQADV 8HPQ A UNP P0DTC2 PRO 26 DELETION SEQADV 8HPQ SER A 43 UNP P0DTC2 ALA 27 VARIANT SEQADV 8HPQ A UNP P0DTC2 HIS 69 DELETION SEQADV 8HPQ A UNP P0DTC2 VAL 70 DELETION SEQADV 8HPQ ASP A 156 UNP P0DTC2 GLY 142 VARIANT SEQADV 8HPQ ASP A 353 UNP P0DTC2 GLY 339 VARIANT SEQADV 8HPQ PHE A 385 UNP P0DTC2 SER 371 VARIANT SEQADV 8HPQ PRO A 387 UNP P0DTC2 SER 373 VARIANT SEQADV 8HPQ PHE A 389 UNP P0DTC2 SER 375 VARIANT SEQADV 8HPQ ALA A 390 UNP P0DTC2 THR 376 VARIANT SEQADV 8HPQ ASN A 419 UNP P0DTC2 ASP 405 VARIANT SEQADV 8HPQ SER A 422 UNP P0DTC2 ARG 408 VARIANT SEQADV 8HPQ ASN A 431 UNP P0DTC2 LYS 417 VARIANT SEQADV 8HPQ LYS A 454 UNP P0DTC2 ASN 440 VARIANT SEQADV 8HPQ ARG A 466 UNP P0DTC2 LEU 452 VARIANT SEQADV 8HPQ ASN A 491 UNP P0DTC2 SER 477 VARIANT SEQADV 8HPQ LYS A 492 UNP P0DTC2 THR 478 VARIANT SEQADV 8HPQ ALA A 498 UNP P0DTC2 GLU 484 VARIANT SEQADV 8HPQ VAL A 500 UNP P0DTC2 PHE 486 VARIANT SEQADV 8HPQ ARG A 512 UNP P0DTC2 GLN 498 VARIANT SEQADV 8HPQ TYR A 515 UNP P0DTC2 ASN 501 VARIANT SEQADV 8HPQ HIS A 519 UNP P0DTC2 TYR 505 VARIANT SEQADV 8HPQ GLY A 628 UNP P0DTC2 ASP 614 VARIANT SEQADV 8HPQ TYR A 669 UNP P0DTC2 HIS 655 VARIANT SEQADV 8HPQ LYS A 778 UNP P0DTC2 ASN 764 VARIANT SEQADV 8HPQ TYR A 810 UNP P0DTC2 ASP 796 VARIANT SEQADV 8HPQ PRO A 831 UNP P0DTC2 PHE 817 CONFLICT SEQADV 8HPQ PRO A 906 UNP P0DTC2 ALA 892 CONFLICT SEQADV 8HPQ PRO A 913 UNP P0DTC2 ALA 899 CONFLICT SEQADV 8HPQ PRO A 956 UNP P0DTC2 ALA 942 CONFLICT SEQADV 8HPQ HIS A 968 UNP P0DTC2 GLN 954 VARIANT SEQADV 8HPQ LYS A 983 UNP P0DTC2 ASN 969 VARIANT SEQADV 8HPQ PRO A 1000 UNP P0DTC2 LYS 986 CONFLICT SEQADV 8HPQ PRO A 1001 UNP P0DTC2 VAL 987 CONFLICT SEQADV 8HPQ ILE B 38 UNP P0DTC2 THR 19 CONFLICT SEQADV 8HPQ B UNP P0DTC2 LEU 24 DELETION SEQADV 8HPQ B UNP P0DTC2 PRO 25 DELETION SEQADV 8HPQ B UNP P0DTC2 PRO 26 DELETION SEQADV 8HPQ SER B 43 UNP P0DTC2 ALA 27 VARIANT SEQADV 8HPQ B UNP P0DTC2 HIS 69 DELETION SEQADV 8HPQ B UNP P0DTC2 VAL 70 DELETION SEQADV 8HPQ ASP B 156 UNP P0DTC2 GLY 142 VARIANT SEQADV 8HPQ ASP B 353 UNP P0DTC2 GLY 339 VARIANT SEQADV 8HPQ PHE B 385 UNP P0DTC2 SER 371 VARIANT SEQADV 8HPQ PRO B 387 UNP P0DTC2 SER 373 VARIANT SEQADV 8HPQ PHE B 389 UNP P0DTC2 SER 375 VARIANT SEQADV 8HPQ ALA B 390 UNP P0DTC2 THR 376 VARIANT SEQADV 8HPQ ASN B 419 UNP P0DTC2 ASP 405 VARIANT SEQADV 8HPQ SER B 422 UNP P0DTC2 ARG 408 VARIANT SEQADV 8HPQ ASN B 431 UNP P0DTC2 LYS 417 VARIANT SEQADV 8HPQ LYS B 454 UNP P0DTC2 ASN 440 VARIANT SEQADV 8HPQ ARG B 466 UNP P0DTC2 LEU 452 VARIANT SEQADV 8HPQ ASN B 491 UNP P0DTC2 SER 477 VARIANT SEQADV 8HPQ LYS B 492 UNP P0DTC2 THR 478 VARIANT SEQADV 8HPQ ALA B 498 UNP P0DTC2 GLU 484 VARIANT SEQADV 8HPQ VAL B 500 UNP P0DTC2 PHE 486 VARIANT SEQADV 8HPQ ARG B 512 UNP P0DTC2 GLN 498 VARIANT SEQADV 8HPQ TYR B 515 UNP P0DTC2 ASN 501 VARIANT SEQADV 8HPQ HIS B 519 UNP P0DTC2 TYR 505 VARIANT SEQADV 8HPQ GLY B 628 UNP P0DTC2 ASP 614 VARIANT SEQADV 8HPQ TYR B 669 UNP P0DTC2 HIS 655 VARIANT SEQADV 8HPQ LYS B 778 UNP P0DTC2 ASN 764 VARIANT SEQADV 8HPQ TYR B 810 UNP P0DTC2 ASP 796 VARIANT SEQADV 8HPQ PRO B 831 UNP P0DTC2 PHE 817 CONFLICT SEQADV 8HPQ PRO B 906 UNP P0DTC2 ALA 892 CONFLICT SEQADV 8HPQ PRO B 913 UNP P0DTC2 ALA 899 CONFLICT SEQADV 8HPQ PRO B 956 UNP P0DTC2 ALA 942 CONFLICT SEQADV 8HPQ HIS B 968 UNP P0DTC2 GLN 954 VARIANT SEQADV 8HPQ LYS B 983 UNP P0DTC2 ASN 969 VARIANT SEQADV 8HPQ PRO B 1000 UNP P0DTC2 LYS 986 CONFLICT SEQADV 8HPQ PRO B 1001 UNP P0DTC2 VAL 987 CONFLICT SEQADV 8HPQ ILE C 38 UNP P0DTC2 THR 19 CONFLICT SEQADV 8HPQ C UNP P0DTC2 LEU 24 DELETION SEQADV 8HPQ C UNP P0DTC2 PRO 25 DELETION SEQADV 8HPQ C UNP P0DTC2 PRO 26 DELETION SEQADV 8HPQ SER C 43 UNP P0DTC2 ALA 27 VARIANT SEQADV 8HPQ C UNP P0DTC2 HIS 69 DELETION SEQADV 8HPQ C UNP P0DTC2 VAL 70 DELETION SEQADV 8HPQ ASP C 156 UNP P0DTC2 GLY 142 VARIANT SEQADV 8HPQ ASP C 353 UNP P0DTC2 GLY 339 VARIANT SEQADV 8HPQ PHE C 385 UNP P0DTC2 SER 371 VARIANT SEQADV 8HPQ PRO C 387 UNP P0DTC2 SER 373 VARIANT SEQADV 8HPQ PHE C 389 UNP P0DTC2 SER 375 VARIANT SEQADV 8HPQ ALA C 390 UNP P0DTC2 THR 376 VARIANT SEQADV 8HPQ ASN C 419 UNP P0DTC2 ASP 405 VARIANT SEQADV 8HPQ SER C 422 UNP P0DTC2 ARG 408 VARIANT SEQADV 8HPQ ASN C 431 UNP P0DTC2 LYS 417 VARIANT SEQADV 8HPQ LYS C 454 UNP P0DTC2 ASN 440 VARIANT SEQADV 8HPQ ARG C 466 UNP P0DTC2 LEU 452 VARIANT SEQADV 8HPQ ASN C 491 UNP P0DTC2 SER 477 VARIANT SEQADV 8HPQ LYS C 492 UNP P0DTC2 THR 478 VARIANT SEQADV 8HPQ ALA C 498 UNP P0DTC2 GLU 484 VARIANT SEQADV 8HPQ VAL C 500 UNP P0DTC2 PHE 486 VARIANT SEQADV 8HPQ ARG C 512 UNP P0DTC2 GLN 498 VARIANT SEQADV 8HPQ TYR C 515 UNP P0DTC2 ASN 501 VARIANT SEQADV 8HPQ HIS C 519 UNP P0DTC2 TYR 505 VARIANT SEQADV 8HPQ GLY C 628 UNP P0DTC2 ASP 614 VARIANT SEQADV 8HPQ TYR C 669 UNP P0DTC2 HIS 655 VARIANT SEQADV 8HPQ LYS C 778 UNP P0DTC2 ASN 764 VARIANT SEQADV 8HPQ TYR C 810 UNP P0DTC2 ASP 796 VARIANT SEQADV 8HPQ PRO C 831 UNP P0DTC2 PHE 817 CONFLICT SEQADV 8HPQ PRO C 906 UNP P0DTC2 ALA 892 CONFLICT SEQADV 8HPQ PRO C 913 UNP P0DTC2 ALA 899 CONFLICT SEQADV 8HPQ PRO C 956 UNP P0DTC2 ALA 942 CONFLICT SEQADV 8HPQ HIS C 968 UNP P0DTC2 GLN 954 VARIANT SEQADV 8HPQ LYS C 983 UNP P0DTC2 ASN 969 VARIANT SEQADV 8HPQ PRO C 1000 UNP P0DTC2 LYS 986 CONFLICT SEQADV 8HPQ PRO C 1001 UNP P0DTC2 VAL 987 CONFLICT SEQRES 1 A 1129 GLN CYS VAL ASN LEU ILE THR ARG THR GLN SER TYR THR SEQRES 2 A 1129 ASN SER PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL SEQRES 3 A 1129 PHE ARG SER SER VAL LEU HIS SER THR GLN ASP LEU PHE SEQRES 4 A 1129 LEU PRO PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE SEQRES 5 A 1129 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO VAL SEQRES 6 A 1129 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 7 A 1129 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 8 A 1129 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 9 A 1129 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 10 A 1129 CYS ASN ASP PRO PHE LEU ASP VAL TYR TYR HIS LYS ASN SEQRES 11 A 1129 ASN LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SEQRES 12 A 1129 SER ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO SEQRES 13 A 1129 PHE LEU MET ASP LEU GLU GLY LYS GLN GLY ASN PHE LYS SEQRES 14 A 1129 ASN LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR SEQRES 15 A 1129 PHE LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU VAL SEQRES 16 A 1129 ARG ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU SEQRES 17 A 1129 VAL ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN SEQRES 18 A 1129 THR LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO GLY SEQRES 19 A 1129 ASP SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR SEQRES 20 A 1129 TYR VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS SEQRES 21 A 1129 TYR ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS SEQRES 22 A 1129 ALA LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SEQRES 23 A 1129 SER PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN SEQRES 24 A 1129 PHE ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO SEQRES 25 A 1129 ASN ILE THR ASN LEU CYS PRO PHE ASP GLU VAL PHE ASN SEQRES 26 A 1129 ALA THR ARG PHE ALA SER VAL TYR ALA TRP ASN ARG LYS SEQRES 27 A 1129 ARG ILE SER ASN CYS VAL ALA ASP TYR SER VAL LEU TYR SEQRES 28 A 1129 ASN PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SEQRES 29 A 1129 SER PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL SEQRES 30 A 1129 TYR ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER SEQRES 31 A 1129 GLN ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR SEQRES 32 A 1129 ASN TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE SEQRES 33 A 1129 ALA TRP ASN SER ASN LYS LEU ASP SER LYS VAL GLY GLY SEQRES 34 A 1129 ASN TYR ASN TYR ARG TYR ARG LEU PHE ARG LYS SER ASN SEQRES 35 A 1129 LEU LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR SEQRES 36 A 1129 GLN ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY VAL SEQRES 37 A 1129 ASN CYS TYR PHE PRO LEU GLN SER TYR GLY PHE ARG PRO SEQRES 38 A 1129 THR TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL SEQRES 39 A 1129 LEU SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS SEQRES 40 A 1129 GLY PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS SEQRES 41 A 1129 VAL ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL SEQRES 42 A 1129 LEU THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN SEQRES 43 A 1129 PHE GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG SEQRES 44 A 1129 ASP PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SEQRES 45 A 1129 SER PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN SEQRES 46 A 1129 THR SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN SEQRES 47 A 1129 CYS THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU SEQRES 48 A 1129 THR PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL SEQRES 49 A 1129 PHE GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR SEQRES 50 A 1129 VAL ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA SEQRES 51 A 1129 GLY ILE CYS ALA SER TYR GLN THR GLN THR ASN SER PRO SEQRES 52 A 1129 ARG ARG ALA ARG SER VAL ALA SER GLN SER ILE ILE ALA SEQRES 53 A 1129 TYR THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SEQRES 54 A 1129 SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SEQRES 55 A 1129 SER VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS SEQRES 56 A 1129 THR SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER SEQRES 57 A 1129 THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE SEQRES 58 A 1129 CYS THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL SEQRES 59 A 1129 GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL SEQRES 60 A 1129 LYS GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY SEQRES 61 A 1129 GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS SEQRES 62 A 1129 PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN SEQRES 63 A 1129 LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR SEQRES 64 A 1129 GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE SEQRES 65 A 1129 CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO SEQRES 66 A 1129 LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA SEQRES 67 A 1129 LEU LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY SEQRES 68 A 1129 ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET SEQRES 69 A 1129 ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL SEQRES 70 A 1129 LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SEQRES 71 A 1129 SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR SEQRES 72 A 1129 PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS SEQRES 73 A 1129 ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SEQRES 74 A 1129 SER LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE SEQRES 75 A 1129 LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE SEQRES 76 A 1129 ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR SEQRES 77 A 1129 TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG SEQRES 78 A 1129 ALA SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS SEQRES 79 A 1129 VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS SEQRES 80 A 1129 GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS SEQRES 81 A 1129 GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN SEQRES 82 A 1129 GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP SEQRES 83 A 1129 GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER SEQRES 84 A 1129 ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR SEQRES 85 A 1129 GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER SEQRES 86 A 1129 GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR SEQRES 87 A 1129 VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 1 H 231 GLN ILE THR LEU LYS GLU SER GLY PRO THR LEU VAL LYS SEQRES 2 H 231 PRO THR GLN THR LEU THR LEU THR CYS THR PHE SER GLY SEQRES 3 H 231 PHE SER LEU SER THR SER GLY VAL GLY VAL ALA TRP ILE SEQRES 4 H 231 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 H 231 ILE TYR TRP ASP ASN ASP LYS ARG SER SER PRO SER LEU SEQRES 6 H 231 ASN ASN ARG LEU THR ILE THR LYS ASP THR SER LYS ASN SEQRES 7 H 231 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO GLU ASP SEQRES 8 H 231 THR ALA THR TYR TYR CYS ALA HIS PHE PHE SER HIS TYR SEQRES 9 H 231 ASP SER SER ASN TYR TYR TYR GLY SER TRP PHE ASP PRO SEQRES 10 H 231 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 H 231 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 H 231 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 H 231 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 H 231 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 H 231 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 H 231 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 H 231 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 H 231 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 L 215 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 L 215 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 L 215 GLN SER PHE ASP SER ARG TYR LEU GLY TRP TYR GLN GLN SEQRES 4 L 215 LYS SER GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 L 215 SER SER ARG ALA THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 L 215 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 L 215 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 L 215 PHE GLY ASP SER PRO PHE THR PHE GLY GLN GLY THR LYS SEQRES 9 L 215 LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 M 224 VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN PRO SEQRES 2 M 224 GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLU ILE SEQRES 3 M 224 THR VAL SER SER ASN TYR MET ASN TRP VAL ARG GLN ALA SEQRES 4 M 224 PRO GLY LYS GLY LEU GLU TRP VAL SER VAL VAL TYR PRO SEQRES 5 M 224 GLY GLY SER THR PHE TYR THR ASP SER VAL LYS GLY ARG SEQRES 6 M 224 PHE THR ILE SER ARG ASP ASN SER LYS ASN THR LEU TYR SEQRES 7 M 224 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 8 M 224 TYR TYR CYS ALA ARG GLU SER GLY GLY PHE PRO LEU ALA SEQRES 9 M 224 GLU GLY ALA PHE ASP ILE TRP GLY GLN GLY THR MET VAL SEQRES 10 M 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 M 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 M 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 M 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 M 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 M 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 M 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 M 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 M 224 LYS SER CYS SEQRES 1 N 216 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 N 216 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 N 216 GLN SER ILE SER THR HIS LEU HIS TRP TYR GLN GLN LYS SEQRES 4 N 216 PRO GLY LYS ALA PRO LYS LEU LEU ILE SER ALA ALA SER SEQRES 5 N 216 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 N 216 GLY SER GLY THR ASP PHE THR LEU THR ILE THR SER LEU SEQRES 7 N 216 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 N 216 TYR SER THR PRO ARG GLY LEU SER PHE GLY GLY GLY THR SEQRES 9 N 216 LYS VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 10 N 216 PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY SEQRES 11 N 216 THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO SEQRES 12 N 216 ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU SEQRES 13 N 216 GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SEQRES 14 N 216 SER LYS ASP SER THR TYR SER LEU SER SER THR LEU THR SEQRES 15 N 216 LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA SEQRES 16 N 216 CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR SEQRES 17 N 216 LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 B 1129 GLN CYS VAL ASN LEU ILE THR ARG THR GLN SER TYR THR SEQRES 2 B 1129 ASN SER PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL SEQRES 3 B 1129 PHE ARG SER SER VAL LEU HIS SER THR GLN ASP LEU PHE SEQRES 4 B 1129 LEU PRO PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE SEQRES 5 B 1129 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO VAL SEQRES 6 B 1129 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 7 B 1129 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 8 B 1129 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 9 B 1129 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 10 B 1129 CYS ASN ASP PRO PHE LEU ASP VAL TYR TYR HIS LYS ASN SEQRES 11 B 1129 ASN LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SEQRES 12 B 1129 SER ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO SEQRES 13 B 1129 PHE LEU MET ASP LEU GLU GLY LYS GLN GLY ASN PHE LYS SEQRES 14 B 1129 ASN LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR SEQRES 15 B 1129 PHE LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU VAL SEQRES 16 B 1129 ARG ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU SEQRES 17 B 1129 VAL ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN SEQRES 18 B 1129 THR LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO GLY SEQRES 19 B 1129 ASP SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR SEQRES 20 B 1129 TYR VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS SEQRES 21 B 1129 TYR ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS SEQRES 22 B 1129 ALA LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SEQRES 23 B 1129 SER PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN SEQRES 24 B 1129 PHE ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO SEQRES 25 B 1129 ASN ILE THR ASN LEU CYS PRO PHE ASP GLU VAL PHE ASN SEQRES 26 B 1129 ALA THR ARG PHE ALA SER VAL TYR ALA TRP ASN ARG LYS SEQRES 27 B 1129 ARG ILE SER ASN CYS VAL ALA ASP TYR SER VAL LEU TYR SEQRES 28 B 1129 ASN PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SEQRES 29 B 1129 SER PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL SEQRES 30 B 1129 TYR ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER SEQRES 31 B 1129 GLN ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR SEQRES 32 B 1129 ASN TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE SEQRES 33 B 1129 ALA TRP ASN SER ASN LYS LEU ASP SER LYS VAL GLY GLY SEQRES 34 B 1129 ASN TYR ASN TYR ARG TYR ARG LEU PHE ARG LYS SER ASN SEQRES 35 B 1129 LEU LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR SEQRES 36 B 1129 GLN ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY VAL SEQRES 37 B 1129 ASN CYS TYR PHE PRO LEU GLN SER TYR GLY PHE ARG PRO SEQRES 38 B 1129 THR TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL SEQRES 39 B 1129 LEU SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS SEQRES 40 B 1129 GLY PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS SEQRES 41 B 1129 VAL ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL SEQRES 42 B 1129 LEU THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN SEQRES 43 B 1129 PHE GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG SEQRES 44 B 1129 ASP PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SEQRES 45 B 1129 SER PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN SEQRES 46 B 1129 THR SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN SEQRES 47 B 1129 CYS THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU SEQRES 48 B 1129 THR PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL SEQRES 49 B 1129 PHE GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR SEQRES 50 B 1129 VAL ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA SEQRES 51 B 1129 GLY ILE CYS ALA SER TYR GLN THR GLN THR ASN SER PRO SEQRES 52 B 1129 ARG ARG ALA ARG SER VAL ALA SER GLN SER ILE ILE ALA SEQRES 53 B 1129 TYR THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SEQRES 54 B 1129 SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SEQRES 55 B 1129 SER VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS SEQRES 56 B 1129 THR SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER SEQRES 57 B 1129 THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE SEQRES 58 B 1129 CYS THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL SEQRES 59 B 1129 GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL SEQRES 60 B 1129 LYS GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY SEQRES 61 B 1129 GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS SEQRES 62 B 1129 PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN SEQRES 63 B 1129 LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR SEQRES 64 B 1129 GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE SEQRES 65 B 1129 CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO SEQRES 66 B 1129 LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA SEQRES 67 B 1129 LEU LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY SEQRES 68 B 1129 ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET SEQRES 69 B 1129 ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL SEQRES 70 B 1129 LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SEQRES 71 B 1129 SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR SEQRES 72 B 1129 PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS SEQRES 73 B 1129 ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SEQRES 74 B 1129 SER LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE SEQRES 75 B 1129 LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE SEQRES 76 B 1129 ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR SEQRES 77 B 1129 TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG SEQRES 78 B 1129 ALA SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS SEQRES 79 B 1129 VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS SEQRES 80 B 1129 GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS SEQRES 81 B 1129 GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN SEQRES 82 B 1129 GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP SEQRES 83 B 1129 GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER SEQRES 84 B 1129 ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR SEQRES 85 B 1129 GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER SEQRES 86 B 1129 GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR SEQRES 87 B 1129 VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 1 P 231 GLN ILE THR LEU LYS GLU SER GLY PRO THR LEU VAL LYS SEQRES 2 P 231 PRO THR GLN THR LEU THR LEU THR CYS THR PHE SER GLY SEQRES 3 P 231 PHE SER LEU SER THR SER GLY VAL GLY VAL ALA TRP ILE SEQRES 4 P 231 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 P 231 ILE TYR TRP ASP ASN ASP LYS ARG SER SER PRO SER LEU SEQRES 6 P 231 ASN ASN ARG LEU THR ILE THR LYS ASP THR SER LYS ASN SEQRES 7 P 231 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO GLU ASP SEQRES 8 P 231 THR ALA THR TYR TYR CYS ALA HIS PHE PHE SER HIS TYR SEQRES 9 P 231 ASP SER SER ASN TYR TYR TYR GLY SER TRP PHE ASP PRO SEQRES 10 P 231 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 P 231 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 P 231 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 P 231 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 P 231 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 P 231 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 P 231 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 P 231 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 P 231 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 Q 215 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 Q 215 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 Q 215 GLN SER PHE ASP SER ARG TYR LEU GLY TRP TYR GLN GLN SEQRES 4 Q 215 LYS SER GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 Q 215 SER SER ARG ALA THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 Q 215 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 Q 215 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 Q 215 PHE GLY ASP SER PRO PHE THR PHE GLY GLN GLY THR LYS SEQRES 9 Q 215 LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 Q 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 Q 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 Q 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 Q 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 Q 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 Q 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 Q 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 Q 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 E 224 VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN PRO SEQRES 2 E 224 GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLU ILE SEQRES 3 E 224 THR VAL SER SER ASN TYR MET ASN TRP VAL ARG GLN ALA SEQRES 4 E 224 PRO GLY LYS GLY LEU GLU TRP VAL SER VAL VAL TYR PRO SEQRES 5 E 224 GLY GLY SER THR PHE TYR THR ASP SER VAL LYS GLY ARG SEQRES 6 E 224 PHE THR ILE SER ARG ASP ASN SER LYS ASN THR LEU TYR SEQRES 7 E 224 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 8 E 224 TYR TYR CYS ALA ARG GLU SER GLY GLY PHE PRO LEU ALA SEQRES 9 E 224 GLU GLY ALA PHE ASP ILE TRP GLY GLN GLY THR MET VAL SEQRES 10 E 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 E 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 E 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 E 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 E 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 E 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 E 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 E 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 E 224 LYS SER CYS SEQRES 1 F 216 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 F 216 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 F 216 GLN SER ILE SER THR HIS LEU HIS TRP TYR GLN GLN LYS SEQRES 4 F 216 PRO GLY LYS ALA PRO LYS LEU LEU ILE SER ALA ALA SER SEQRES 5 F 216 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 F 216 GLY SER GLY THR ASP PHE THR LEU THR ILE THR SER LEU SEQRES 7 F 216 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 F 216 TYR SER THR PRO ARG GLY LEU SER PHE GLY GLY GLY THR SEQRES 9 F 216 LYS VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 10 F 216 PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY SEQRES 11 F 216 THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO SEQRES 12 F 216 ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU SEQRES 13 F 216 GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SEQRES 14 F 216 SER LYS ASP SER THR TYR SER LEU SER SER THR LEU THR SEQRES 15 F 216 LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA SEQRES 16 F 216 CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR SEQRES 17 F 216 LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 C 1129 GLN CYS VAL ASN LEU ILE THR ARG THR GLN SER TYR THR SEQRES 2 C 1129 ASN SER PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL SEQRES 3 C 1129 PHE ARG SER SER VAL LEU HIS SER THR GLN ASP LEU PHE SEQRES 4 C 1129 LEU PRO PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE SEQRES 5 C 1129 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO VAL SEQRES 6 C 1129 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 7 C 1129 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 8 C 1129 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 9 C 1129 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 10 C 1129 CYS ASN ASP PRO PHE LEU ASP VAL TYR TYR HIS LYS ASN SEQRES 11 C 1129 ASN LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SEQRES 12 C 1129 SER ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO SEQRES 13 C 1129 PHE LEU MET ASP LEU GLU GLY LYS GLN GLY ASN PHE LYS SEQRES 14 C 1129 ASN LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR SEQRES 15 C 1129 PHE LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU VAL SEQRES 16 C 1129 ARG ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU SEQRES 17 C 1129 VAL ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN SEQRES 18 C 1129 THR LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO GLY SEQRES 19 C 1129 ASP SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR SEQRES 20 C 1129 TYR VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS SEQRES 21 C 1129 TYR ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS SEQRES 22 C 1129 ALA LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SEQRES 23 C 1129 SER PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN SEQRES 24 C 1129 PHE ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO SEQRES 25 C 1129 ASN ILE THR ASN LEU CYS PRO PHE ASP GLU VAL PHE ASN SEQRES 26 C 1129 ALA THR ARG PHE ALA SER VAL TYR ALA TRP ASN ARG LYS SEQRES 27 C 1129 ARG ILE SER ASN CYS VAL ALA ASP TYR SER VAL LEU TYR SEQRES 28 C 1129 ASN PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SEQRES 29 C 1129 SER PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL SEQRES 30 C 1129 TYR ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER SEQRES 31 C 1129 GLN ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR SEQRES 32 C 1129 ASN TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE SEQRES 33 C 1129 ALA TRP ASN SER ASN LYS LEU ASP SER LYS VAL GLY GLY SEQRES 34 C 1129 ASN TYR ASN TYR ARG TYR ARG LEU PHE ARG LYS SER ASN SEQRES 35 C 1129 LEU LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR SEQRES 36 C 1129 GLN ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY VAL SEQRES 37 C 1129 ASN CYS TYR PHE PRO LEU GLN SER TYR GLY PHE ARG PRO SEQRES 38 C 1129 THR TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL SEQRES 39 C 1129 LEU SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS SEQRES 40 C 1129 GLY PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS SEQRES 41 C 1129 VAL ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL SEQRES 42 C 1129 LEU THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN SEQRES 43 C 1129 PHE GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG SEQRES 44 C 1129 ASP PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SEQRES 45 C 1129 SER PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN SEQRES 46 C 1129 THR SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN SEQRES 47 C 1129 CYS THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU SEQRES 48 C 1129 THR PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL SEQRES 49 C 1129 PHE GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR SEQRES 50 C 1129 VAL ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA SEQRES 51 C 1129 GLY ILE CYS ALA SER TYR GLN THR GLN THR ASN SER PRO SEQRES 52 C 1129 ARG ARG ALA ARG SER VAL ALA SER GLN SER ILE ILE ALA SEQRES 53 C 1129 TYR THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SEQRES 54 C 1129 SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SEQRES 55 C 1129 SER VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS SEQRES 56 C 1129 THR SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER SEQRES 57 C 1129 THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE SEQRES 58 C 1129 CYS THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL SEQRES 59 C 1129 GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL SEQRES 60 C 1129 LYS GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY SEQRES 61 C 1129 GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS SEQRES 62 C 1129 PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN SEQRES 63 C 1129 LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR SEQRES 64 C 1129 GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE SEQRES 65 C 1129 CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO SEQRES 66 C 1129 LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA SEQRES 67 C 1129 LEU LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY SEQRES 68 C 1129 ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET SEQRES 69 C 1129 ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL SEQRES 70 C 1129 LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SEQRES 71 C 1129 SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR SEQRES 72 C 1129 PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS SEQRES 73 C 1129 ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SEQRES 74 C 1129 SER LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE SEQRES 75 C 1129 LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE SEQRES 76 C 1129 ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR SEQRES 77 C 1129 TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG SEQRES 78 C 1129 ALA SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS SEQRES 79 C 1129 VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS SEQRES 80 C 1129 GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS SEQRES 81 C 1129 GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN SEQRES 82 C 1129 GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP SEQRES 83 C 1129 GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER SEQRES 84 C 1129 ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR SEQRES 85 C 1129 GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER SEQRES 86 C 1129 GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR SEQRES 87 C 1129 VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 1 I 231 GLN ILE THR LEU LYS GLU SER GLY PRO THR LEU VAL LYS SEQRES 2 I 231 PRO THR GLN THR LEU THR LEU THR CYS THR PHE SER GLY SEQRES 3 I 231 PHE SER LEU SER THR SER GLY VAL GLY VAL ALA TRP ILE SEQRES 4 I 231 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 I 231 ILE TYR TRP ASP ASN ASP LYS ARG SER SER PRO SER LEU SEQRES 6 I 231 ASN ASN ARG LEU THR ILE THR LYS ASP THR SER LYS ASN SEQRES 7 I 231 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO GLU ASP SEQRES 8 I 231 THR ALA THR TYR TYR CYS ALA HIS PHE PHE SER HIS TYR SEQRES 9 I 231 ASP SER SER ASN TYR TYR TYR GLY SER TRP PHE ASP PRO SEQRES 10 I 231 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 I 231 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 I 231 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 I 231 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 I 231 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 I 231 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 I 231 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 I 231 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 I 231 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 J 215 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 J 215 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 J 215 GLN SER PHE ASP SER ARG TYR LEU GLY TRP TYR GLN GLN SEQRES 4 J 215 LYS SER GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 J 215 SER SER ARG ALA THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 J 215 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 J 215 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 J 215 PHE GLY ASP SER PRO PHE THR PHE GLY GLN GLY THR LYS SEQRES 9 J 215 LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 J 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 J 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 J 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 J 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 J 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 J 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 J 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 J 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 R 224 VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN PRO SEQRES 2 R 224 GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLU ILE SEQRES 3 R 224 THR VAL SER SER ASN TYR MET ASN TRP VAL ARG GLN ALA SEQRES 4 R 224 PRO GLY LYS GLY LEU GLU TRP VAL SER VAL VAL TYR PRO SEQRES 5 R 224 GLY GLY SER THR PHE TYR THR ASP SER VAL LYS GLY ARG SEQRES 6 R 224 PHE THR ILE SER ARG ASP ASN SER LYS ASN THR LEU TYR SEQRES 7 R 224 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 8 R 224 TYR TYR CYS ALA ARG GLU SER GLY GLY PHE PRO LEU ALA SEQRES 9 R 224 GLU GLY ALA PHE ASP ILE TRP GLY GLN GLY THR MET VAL SEQRES 10 R 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 R 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 R 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 R 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 R 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 R 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 R 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 R 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 R 224 LYS SER CYS SEQRES 1 S 216 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 S 216 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 S 216 GLN SER ILE SER THR HIS LEU HIS TRP TYR GLN GLN LYS SEQRES 4 S 216 PRO GLY LYS ALA PRO LYS LEU LEU ILE SER ALA ALA SER SEQRES 5 S 216 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 S 216 GLY SER GLY THR ASP PHE THR LEU THR ILE THR SER LEU SEQRES 7 S 216 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 S 216 TYR SER THR PRO ARG GLY LEU SER PHE GLY GLY GLY THR SEQRES 9 S 216 LYS VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 10 S 216 PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY SEQRES 11 S 216 THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO SEQRES 12 S 216 ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU SEQRES 13 S 216 GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SEQRES 14 S 216 SER LYS ASP SER THR TYR SER LEU SER SER THR LEU THR SEQRES 15 S 216 LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA SEQRES 16 S 216 CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR SEQRES 17 S 216 LYS SER PHE ASN ARG GLY GLU CYS HET NAG A1201 14 HET NAG B1201 14 HET NAG C1201 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 16 NAG 3(C8 H15 N O6) HELIX 1 AA1 ASP A 308 LYS A 318 1 11 HELIX 2 AA2 PRO A 351 ALA A 358 1 8 HELIX 3 AA3 SER A 363 TRP A 367 5 5 HELIX 4 AA4 TYR A 379 PHE A 385 1 7 HELIX 5 AA5 SER A 397 LEU A 404 5 8 HELIX 6 AA6 GLU A 420 ILE A 424 5 5 HELIX 7 AA7 ASN A 431 ASN A 436 1 6 HELIX 8 AA8 ASN A 630 VAL A 634 5 5 HELIX 9 AA9 ASP A 751 GLY A 758 1 8 HELIX 10 AB1 SER A 760 LEU A 768 1 9 HELIX 11 AB2 GLN A 769 GLY A 771 5 3 HELIX 12 AB3 SER A 772 ALA A 797 1 26 HELIX 13 AB4 SER A 830 VAL A 840 1 11 HELIX 14 AB5 THR A 880 SER A 898 1 19 HELIX 15 AB6 PRO A 911 ILE A 923 1 13 HELIX 16 AB7 THR A 926 ASN A 933 1 8 HELIX 17 AB8 ASN A 933 THR A 955 1 23 HELIX 18 AB9 LEU A 959 GLN A 979 1 21 HELIX 19 AC1 LEU A 980 SER A 982 5 3 HELIX 20 AC2 VAL A 990 LEU A 998 1 9 HELIX 21 AC3 ASP A 999 CYS A 1046 1 48 HELIX 22 AC4 LEU A 1155 SER A 1161 1 7 HELIX 23 AC5 ASP H 88 THR H 92 5 5 HELIX 24 AC6 SER H 171 ALA H 173 5 3 HELIX 25 AC7 PRO H 200 LEU H 204 5 5 HELIX 26 AC8 ASP L 30 ARG L 32 5 3 HELIX 27 AC9 SER L 183 GLU L 188 1 6 HELIX 28 AD1 ASP M 61 LYS M 64 5 4 HELIX 29 AD2 ARG M 86 THR M 90 5 5 HELIX 30 AD3 SER M 165 ALA M 167 5 3 HELIX 31 AD4 SER M 196 GLN M 201 1 6 HELIX 32 AD5 SER N 123 LYS N 128 1 6 HELIX 33 AD6 LYS N 185 LYS N 190 1 6 HELIX 34 AD7 ASP B 308 LYS B 318 1 11 HELIX 35 AD8 PRO B 351 ALA B 358 1 8 HELIX 36 AD9 SER B 363 TRP B 367 5 5 HELIX 37 AE1 TYR B 379 PHE B 385 1 7 HELIX 38 AE2 SER B 397 LEU B 404 5 8 HELIX 39 AE3 GLU B 420 ILE B 424 5 5 HELIX 40 AE4 ASN B 431 ASN B 436 1 6 HELIX 41 AE5 ASN B 630 VAL B 634 5 5 HELIX 42 AE6 ASP B 751 GLY B 758 1 8 HELIX 43 AE7 SER B 760 LEU B 768 1 9 HELIX 44 AE8 GLN B 769 GLY B 771 5 3 HELIX 45 AE9 SER B 772 ALA B 797 1 26 HELIX 46 AF1 SER B 830 VAL B 840 1 11 HELIX 47 AF2 THR B 880 SER B 898 1 19 HELIX 48 AF3 PRO B 911 ILE B 923 1 13 HELIX 49 AF4 THR B 926 ASN B 933 1 8 HELIX 50 AF5 ASN B 933 THR B 955 1 23 HELIX 51 AF6 LEU B 959 GLN B 979 1 21 HELIX 52 AF7 LEU B 980 SER B 982 5 3 HELIX 53 AF8 VAL B 990 LEU B 998 1 9 HELIX 54 AF9 ASP B 999 CYS B 1046 1 48 HELIX 55 AG1 LEU B 1155 SER B 1161 1 7 HELIX 56 AG2 ASP P 88 THR P 92 5 5 HELIX 57 AG3 SER P 171 ALA P 173 5 3 HELIX 58 AG4 PRO P 200 LEU P 204 5 5 HELIX 59 AG5 ASP Q 30 ARG Q 32 5 3 HELIX 60 AG6 SER Q 183 GLU Q 188 1 6 HELIX 61 AG7 ASP E 61 LYS E 64 5 4 HELIX 62 AG8 ARG E 86 THR E 90 5 5 HELIX 63 AG9 SER E 165 ALA E 167 5 3 HELIX 64 AH1 SER E 196 GLN E 201 1 6 HELIX 65 AH2 SER F 123 LYS F 128 1 6 HELIX 66 AH3 LYS F 185 LYS F 190 1 6 HELIX 67 AH4 ASP C 308 LYS C 318 1 11 HELIX 68 AH5 PRO C 351 ALA C 358 1 8 HELIX 69 AH6 SER C 363 TRP C 367 5 5 HELIX 70 AH7 TYR C 379 PHE C 385 1 7 HELIX 71 AH8 SER C 397 LEU C 404 5 8 HELIX 72 AH9 GLU C 420 ILE C 424 5 5 HELIX 73 AI1 ASN C 431 ASN C 436 1 6 HELIX 74 AI2 ASN C 630 VAL C 634 5 5 HELIX 75 AI3 ASP C 751 GLY C 758 1 8 HELIX 76 AI4 SER C 760 LEU C 768 1 9 HELIX 77 AI5 GLN C 769 GLY C 771 5 3 HELIX 78 AI6 SER C 772 ALA C 797 1 26 HELIX 79 AI7 SER C 830 VAL C 840 1 11 HELIX 80 AI8 THR C 880 SER C 898 1 19 HELIX 81 AI9 PRO C 911 ILE C 923 1 13 HELIX 82 AJ1 THR C 926 ASN C 933 1 8 HELIX 83 AJ2 ASN C 933 THR C 955 1 23 HELIX 84 AJ3 LEU C 959 GLN C 979 1 21 HELIX 85 AJ4 LEU C 980 SER C 982 5 3 HELIX 86 AJ5 VAL C 990 LEU C 998 1 9 HELIX 87 AJ6 ASP C 999 CYS C 1046 1 48 HELIX 88 AJ7 LEU C 1155 SER C 1161 1 7 HELIX 89 AJ8 ASP I 88 THR I 92 5 5 HELIX 90 AJ9 SER I 171 ALA I 173 5 3 HELIX 91 AK1 PRO I 200 LEU I 204 5 5 HELIX 92 AK2 ASP J 30 ARG J 32 5 3 HELIX 93 AK3 SER J 183 GLU J 188 1 6 HELIX 94 AK4 ASP R 61 LYS R 64 5 4 HELIX 95 AK5 ARG R 86 THR R 90 5 5 HELIX 96 AK6 SER R 165 ALA R 167 5 3 HELIX 97 AK7 SER R 196 GLN R 201 1 6 HELIX 98 AK8 SER S 123 LYS S 128 1 6 HELIX 99 AK9 LYS S 185 LYS S 190 1 6 SHEET 1 AA1 7 THR A 45 ASN A 46 0 SHEET 2 AA1 7 ASN A 77 ALA A 83 -1 O VAL A 78 N THR A 45 SHEET 3 AA1 7 ALA A 277 TYR A 283 -1 O TYR A 279 N PHE A 81 SHEET 4 AA1 7 GLY A 103 GLU A 110 -1 N TYR A 105 O GLY A 282 SHEET 5 AA1 7 ASN A 202 ILE A 211 -1 O PHE A 206 N PHE A 106 SHEET 6 AA1 7 TYR A 214 PRO A 223 -1 O LYS A 220 N GLU A 205 SHEET 7 AA1 7 GLU A 238 PRO A 244 -1 O GLU A 238 N SER A 219 SHEET 1 AA2 7 VAL A 58 PHE A 59 0 SHEET 2 AA2 7 PHE B 579 ARG B 581 1 O PHE B 579 N PHE A 59 SHEET 3 AA2 7 THR B 587 ARG B 591 -1 O ALA B 589 N GLY B 580 SHEET 4 AA2 7 ILE B 598 PRO B 603 -1 O ILE B 601 N ASP B 588 SHEET 5 AA2 7 LEU B 560 GLU B 568 -1 N VAL B 565 O THR B 602 SHEET 6 AA2 7 CYS B 552 PHE B 557 -1 N VAL B 553 O GLY B 564 SHEET 7 AA2 7 SER B 339 ARG B 342 1 N ARG B 342 O ASN B 556 SHEET 1 AA3 3 LEU A 64 PHE A 71 0 SHEET 2 AA3 3 GLN A 285 TYR A 293 -1 O LEU A 291 N HIS A 65 SHEET 3 AA3 3 ILE A 299 ASP A 304 -1 O ASP A 301 N LYS A 292 SHEET 1 AA4 6 VAL A 97 PRO A 99 0 SHEET 2 AA4 6 ARG A 251 LEU A 255 -1 O PHE A 252 N LEU A 98 SHEET 3 AA4 6 GLY A 117 GLY A 121 -1 N GLY A 117 O LEU A 255 SHEET 4 AA4 6 SER A 130 ASN A 135 -1 O LEU A 131 N PHE A 120 SHEET 5 AA4 6 VAL A 140 CYS A 145 -1 O LYS A 143 N LEU A 132 SHEET 6 AA4 6 PHE A 182 SER A 186 -1 O TYR A 184 N ILE A 142 SHEET 1 AA5 2 PHE A 147 LEU A 155 0 SHEET 2 AA5 2 PHE A 171 ALA A 177 -1 O SER A 175 N GLN A 148 SHEET 1 AA6 5 GLY A 325 SER A 330 0 SHEET 2 AA6 5 VAL A 609 THR A 613 -1 O VAL A 609 N SER A 330 SHEET 3 AA6 5 ALA A 623 GLN A 627 -1 O LEU A 625 N SER A 610 SHEET 4 AA6 5 GLY A 662 ILE A 665 -1 O ILE A 665 N VAL A 624 SHEET 5 AA6 5 VAL A 656 GLN A 658 -1 N PHE A 657 O LEU A 664 SHEET 1 AA7 7 SER A 339 ARG A 342 0 SHEET 2 AA7 7 CYS A 552 PHE A 557 1 O ASN A 556 N ARG A 342 SHEET 3 AA7 7 LEU A 560 GLU A 568 -1 O GLY A 564 N VAL A 553 SHEET 4 AA7 7 ILE A 598 PRO A 603 -1 O THR A 602 N VAL A 565 SHEET 5 AA7 7 THR A 587 ARG A 591 -1 N ASP A 588 O ILE A 601 SHEET 6 AA7 7 PHE A 579 ARG A 581 -1 N GLY A 580 O ALA A 589 SHEET 7 AA7 7 VAL C 58 PHE C 59 1 O PHE C 59 N PHE A 579 SHEET 1 AA8 5 ASN A 368 ILE A 372 0 SHEET 2 AA8 5 VAL A 409 ILE A 416 -1 O VAL A 409 N ILE A 372 SHEET 3 AA8 5 TYR A 522 PHE A 529 -1 O VAL A 524 N PHE A 414 SHEET 4 AA8 5 GLY A 445 ASN A 451 -1 N CYS A 446 O LEU A 527 SHEET 5 AA8 5 ALA A 390 CYS A 393 -1 N LYS A 392 O VAL A 447 SHEET 1 AA9 2 ARG A 466 ARG A 468 0 SHEET 2 AA9 2 LEU A 506 SER A 508 -1 O GLN A 507 N TYR A 467 SHEET 1 AB1 2 TYR A 487 GLN A 488 0 SHEET 2 AB1 2 CYS A 502 TYR A 503 -1 O TYR A 503 N TYR A 487 SHEET 1 AB2 4 GLU A 668 TYR A 669 0 SHEET 2 AB2 4 ILE A 707 THR A 710 1 O ALA A 708 N GLU A 668 SHEET 3 AB2 4 ILE A 684 SER A 687 -1 N CYS A 685 O TYR A 709 SHEET 4 AB2 4 ILE A 678 GLY A 681 -1 N ILE A 678 O ALA A 686 SHEET 1 AB3 2 ALA A 715 GLU A 716 0 SHEET 2 AB3 2 GLN C 801 ILE C 802 1 O ILE C 802 N ALA A 715 SHEET 1 AB4 3 SER A 725 PRO A 742 0 SHEET 2 AB4 3 GLY A1073 ALA A1092 -1 O THR A1080 N SER A 735 SHEET 3 AB4 3 TYR A1061 ALA A1070 -1 N TYR A1061 O TYR A1081 SHEET 1 AB5 5 SER A 725 PRO A 742 0 SHEET 2 AB5 5 GLY A1073 ALA A1092 -1 O THR A1080 N SER A 735 SHEET 3 AB5 5 VAL A1108 SER A1111 -1 O SER A1111 N THR A1090 SHEET 4 AB5 5 TRP A1116 THR A1119 -1 O PHE A1117 N VAL A1110 SHEET 5 AB5 5 GLN A1127 ILE A1128 -1 O GLN A1127 N VAL A1118 SHEET 1 AB6 2 LYS A 747 VAL A 750 0 SHEET 2 AB6 2 LEU A 872 LEU A 875 -1 O THR A 873 N SER A 749 SHEET 1 AB7 4 THR A1134 VAL A1136 0 SHEET 2 AB7 4 LYS A1100 PRO A1104 -1 N PHE A1103 O PHE A1135 SHEET 3 AB7 4 ILE A1095 HIS A1097 -1 N HIS A1097 O LYS A1100 SHEET 4 AB7 4 VAL A1147 ASN A1148 1 O VAL A1147 N CYS A1096 SHEET 1 AB8 4 THR H 3 SER H 7 0 SHEET 2 AB8 4 LEU H 18 SER H 25 -1 O THR H 21 N SER H 7 SHEET 3 AB8 4 GLN H 79 MET H 84 -1 O VAL H 80 N CYS H 22 SHEET 4 AB8 4 LEU H 69 ASP H 74 -1 N ASP H 74 O GLN H 79 SHEET 1 AB9 6 LEU H 11 VAL H 12 0 SHEET 2 AB9 6 THR H 122 VAL H 126 1 O THR H 125 N VAL H 12 SHEET 3 AB9 6 ALA H 93 SER H 102 -1 N TYR H 95 O THR H 122 SHEET 4 AB9 6 GLY H 35 GLN H 41 -1 N GLY H 35 O PHE H 100 SHEET 5 AB9 6 GLU H 48 ILE H 53 -1 O ILE H 53 N VAL H 36 SHEET 6 AB9 6 LYS H 59 SER H 61 -1 O ARG H 60 N LEU H 52 SHEET 1 AC1 4 LEU H 11 VAL H 12 0 SHEET 2 AC1 4 THR H 122 VAL H 126 1 O THR H 125 N VAL H 12 SHEET 3 AC1 4 ALA H 93 SER H 102 -1 N TYR H 95 O THR H 122 SHEET 4 AC1 4 SER H 113 TRP H 118 -1 O PRO H 117 N HIS H 99 SHEET 1 AC2 4 SER H 135 LEU H 139 0 SHEET 2 AC2 4 ALA H 151 TYR H 160 -1 O LYS H 158 N SER H 135 SHEET 3 AC2 4 TYR H 191 VAL H 199 -1 O LEU H 193 N VAL H 157 SHEET 4 AC2 4 HIS H 179 THR H 180 -1 N HIS H 179 O VAL H 196 SHEET 1 AC3 4 SER H 135 LEU H 139 0 SHEET 2 AC3 4 ALA H 151 TYR H 160 -1 O LYS H 158 N SER H 135 SHEET 3 AC3 4 TYR H 191 VAL H 199 -1 O LEU H 193 N VAL H 157 SHEET 4 AC3 4 VAL H 184 LEU H 185 -1 N VAL H 184 O SER H 192 SHEET 1 AC4 3 THR H 166 TRP H 169 0 SHEET 2 AC4 3 TYR H 209 HIS H 215 -1 O ASN H 212 N SER H 168 SHEET 3 AC4 3 THR H 220 VAL H 226 -1 O VAL H 222 N VAL H 213 SHEET 1 AC5 4 LEU L 4 SER L 7 0 SHEET 2 AC5 4 ALA L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AC5 4 ASP L 71 ILE L 76 -1 O ILE L 76 N ALA L 19 SHEET 4 AC5 4 PHE L 63 SER L 68 -1 N SER L 64 O THR L 75 SHEET 1 AC6 6 THR L 10 SER L 12 0 SHEET 2 AC6 6 THR L 103 GLU L 106 1 O GLU L 106 N LEU L 11 SHEET 3 AC6 6 VAL L 86 GLN L 91 -1 N TYR L 87 O THR L 103 SHEET 4 AC6 6 LEU L 34 GLN L 39 -1 N GLN L 39 O VAL L 86 SHEET 5 AC6 6 ARG L 46 TYR L 50 -1 O ARG L 46 N GLN L 38 SHEET 6 AC6 6 SER L 54 ARG L 55 -1 O SER L 54 N TYR L 50 SHEET 1 AC7 4 SER L 115 PHE L 119 0 SHEET 2 AC7 4 ALA L 131 PHE L 140 -1 O LEU L 136 N PHE L 117 SHEET 3 AC7 4 TYR L 174 LEU L 182 -1 O SER L 178 N CYS L 135 SHEET 4 AC7 4 SER L 160 VAL L 164 -1 N SER L 163 O SER L 177 SHEET 1 AC8 3 ALA L 145 VAL L 151 0 SHEET 2 AC8 3 VAL L 192 HIS L 199 -1 O THR L 198 N LYS L 146 SHEET 3 AC8 3 VAL L 206 ASN L 211 -1 O LYS L 208 N CYS L 195 SHEET 1 AC9 4 GLN M 3 SER M 7 0 SHEET 2 AC9 4 SER M 17 SER M 25 -1 O ALA M 23 N VAL M 5 SHEET 3 AC9 4 THR M 77 ASN M 83 -1 O MET M 82 N LEU M 18 SHEET 4 AC9 4 PHE M 67 ASP M 72 -1 N SER M 70 O TYR M 79 SHEET 1 AD1 6 GLY M 10 VAL M 12 0 SHEET 2 AD1 6 THR M 116 VAL M 120 1 O THR M 119 N VAL M 12 SHEET 3 AD1 6 ALA M 91 GLY M 100 -1 N TYR M 93 O THR M 116 SHEET 4 AD1 6 TYR M 33 GLN M 39 -1 N ASN M 35 O ALA M 96 SHEET 5 AD1 6 LEU M 45 VAL M 51 -1 O GLU M 46 N ARG M 38 SHEET 6 AD1 6 THR M 57 TYR M 59 -1 O PHE M 58 N VAL M 50 SHEET 1 AD2 4 GLY M 10 VAL M 12 0 SHEET 2 AD2 4 THR M 116 VAL M 120 1 O THR M 119 N VAL M 12 SHEET 3 AD2 4 ALA M 91 GLY M 100 -1 N TYR M 93 O THR M 116 SHEET 4 AD2 4 ALA M 105 TRP M 112 -1 O ALA M 108 N SER M 99 SHEET 1 AD3 4 SER M 129 LEU M 133 0 SHEET 2 AD3 4 ALA M 145 TYR M 154 -1 O LEU M 150 N PHE M 131 SHEET 3 AD3 4 TYR M 185 VAL M 193 -1 O LEU M 187 N VAL M 151 SHEET 4 AD3 4 VAL M 172 THR M 174 -1 N HIS M 173 O VAL M 190 SHEET 1 AD4 4 SER M 129 LEU M 133 0 SHEET 2 AD4 4 ALA M 145 TYR M 154 -1 O LEU M 150 N PHE M 131 SHEET 3 AD4 4 TYR M 185 VAL M 193 -1 O LEU M 187 N VAL M 151 SHEET 4 AD4 4 VAL M 178 LEU M 179 -1 N VAL M 178 O SER M 186 SHEET 1 AD5 3 THR M 160 TRP M 163 0 SHEET 2 AD5 3 TYR M 203 HIS M 209 -1 O ASN M 208 N THR M 160 SHEET 3 AD5 3 THR M 214 VAL M 220 -1 O VAL M 220 N TYR M 203 SHEET 1 AD6 4 MET N 4 SER N 7 0 SHEET 2 AD6 4 VAL N 19 ALA N 25 -1 O ARG N 24 N THR N 5 SHEET 3 AD6 4 ASP N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 4 AD6 4 PHE N 62 SER N 67 -1 N SER N 65 O THR N 72 SHEET 1 AD7 6 SER N 10 ALA N 13 0 SHEET 2 AD7 6 THR N 104 ILE N 108 1 O GLU N 107 N ALA N 13 SHEET 3 AD7 6 THR N 85 GLN N 90 -1 N TYR N 86 O THR N 104 SHEET 4 AD7 6 LEU N 33 GLN N 38 -1 N GLN N 38 O THR N 85 SHEET 5 AD7 6 LYS N 45 SER N 49 -1 O LYS N 45 N GLN N 37 SHEET 6 AD7 6 THR N 53 LEU N 54 -1 O THR N 53 N SER N 49 SHEET 1 AD8 4 SER N 116 PHE N 120 0 SHEET 2 AD8 4 THR N 131 PHE N 141 -1 O VAL N 135 N PHE N 120 SHEET 3 AD8 4 TYR N 175 SER N 184 -1 O LEU N 183 N ALA N 132 SHEET 4 AD8 4 SER N 161 THR N 166 -1 N GLN N 162 O THR N 180 SHEET 1 AD9 4 ALA N 155 GLN N 157 0 SHEET 2 AD9 4 ALA N 146 VAL N 152 -1 N TRP N 150 O GLN N 157 SHEET 3 AD9 4 VAL N 193 HIS N 200 -1 O ALA N 195 N LYS N 151 SHEET 4 AD9 4 VAL N 207 ASN N 212 -1 O PHE N 211 N TYR N 194 SHEET 1 AE1 7 THR B 45 ASN B 46 0 SHEET 2 AE1 7 ASN B 77 ALA B 83 -1 O VAL B 78 N THR B 45 SHEET 3 AE1 7 ALA B 277 TYR B 283 -1 O TYR B 279 N PHE B 81 SHEET 4 AE1 7 GLY B 103 GLU B 110 -1 N TYR B 105 O GLY B 282 SHEET 5 AE1 7 ASN B 202 ILE B 211 -1 O PHE B 206 N PHE B 106 SHEET 6 AE1 7 TYR B 214 PRO B 223 -1 O LYS B 220 N GLU B 205 SHEET 7 AE1 7 GLU B 238 PRO B 244 -1 O GLU B 238 N SER B 219 SHEET 1 AE2 7 VAL B 58 PHE B 59 0 SHEET 2 AE2 7 PHE C 579 ARG C 581 1 O PHE C 579 N PHE B 59 SHEET 3 AE2 7 THR C 587 ARG C 591 -1 O ALA C 589 N GLY C 580 SHEET 4 AE2 7 ILE C 598 PRO C 603 -1 O ILE C 601 N ASP C 588 SHEET 5 AE2 7 LEU C 560 GLU C 568 -1 N VAL C 565 O THR C 602 SHEET 6 AE2 7 CYS C 552 PHE C 557 -1 N VAL C 553 O GLY C 564 SHEET 7 AE2 7 SER C 339 ARG C 342 1 N ARG C 342 O ASN C 556 SHEET 1 AE3 3 LEU B 64 PHE B 71 0 SHEET 2 AE3 3 GLN B 285 TYR B 293 -1 O LEU B 291 N HIS B 65 SHEET 3 AE3 3 ILE B 299 ASP B 304 -1 O ASP B 301 N LYS B 292 SHEET 1 AE4 6 VAL B 97 PRO B 99 0 SHEET 2 AE4 6 ARG B 251 LEU B 255 -1 O PHE B 252 N LEU B 98 SHEET 3 AE4 6 GLY B 117 GLY B 121 -1 N GLY B 117 O LEU B 255 SHEET 4 AE4 6 SER B 130 ASN B 135 -1 O ILE B 133 N TRP B 118 SHEET 5 AE4 6 VAL B 140 CYS B 145 -1 O LYS B 143 N LEU B 132 SHEET 6 AE4 6 PHE B 182 SER B 186 -1 O TYR B 184 N ILE B 142 SHEET 1 AE5 2 PHE B 147 LEU B 155 0 SHEET 2 AE5 2 PHE B 171 ALA B 177 -1 O SER B 175 N GLN B 148 SHEET 1 AE6 5 GLY B 325 ARG B 333 0 SHEET 2 AE6 5 PHE B 606 THR B 613 -1 O GLY B 607 N PHE B 332 SHEET 3 AE6 5 ALA B 623 GLN B 627 -1 O GLN B 627 N GLY B 608 SHEET 4 AE6 5 GLY B 662 ILE B 665 -1 O ILE B 665 N VAL B 624 SHEET 5 AE6 5 VAL B 656 GLN B 658 -1 N PHE B 657 O LEU B 664 SHEET 1 AE7 5 ASN B 368 ILE B 372 0 SHEET 2 AE7 5 VAL B 409 ILE B 416 -1 O VAL B 409 N ILE B 372 SHEET 3 AE7 5 TYR B 522 PHE B 529 -1 O VAL B 524 N PHE B 414 SHEET 4 AE7 5 GLY B 445 ASN B 451 -1 N CYS B 446 O LEU B 527 SHEET 5 AE7 5 ALA B 390 CYS B 393 -1 N LYS B 392 O VAL B 447 SHEET 1 AE8 2 ARG B 466 ARG B 468 0 SHEET 2 AE8 2 LEU B 506 SER B 508 -1 O GLN B 507 N TYR B 467 SHEET 1 AE9 2 TYR B 487 GLN B 488 0 SHEET 2 AE9 2 CYS B 502 TYR B 503 -1 O TYR B 503 N TYR B 487 SHEET 1 AF1 4 GLU B 668 TYR B 669 0 SHEET 2 AF1 4 ILE B 707 THR B 710 1 O ALA B 708 N GLU B 668 SHEET 3 AF1 4 ILE B 684 SER B 687 -1 N CYS B 685 O TYR B 709 SHEET 4 AF1 4 ILE B 678 GLY B 681 -1 N ILE B 678 O ALA B 686 SHEET 1 AF2 3 SER B 725 PRO B 742 0 SHEET 2 AF2 3 GLY B1073 ALA B1092 -1 O THR B1080 N SER B 735 SHEET 3 AF2 3 TYR B1061 ALA B1070 -1 N TYR B1061 O TYR B1081 SHEET 1 AF3 5 SER B 725 PRO B 742 0 SHEET 2 AF3 5 GLY B1073 ALA B1092 -1 O THR B1080 N SER B 735 SHEET 3 AF3 5 VAL B1108 SER B1111 -1 O SER B1111 N THR B1090 SHEET 4 AF3 5 TRP B1116 THR B1119 -1 O PHE B1117 N VAL B1110 SHEET 5 AF3 5 GLN B1127 ILE B1128 -1 O GLN B1127 N VAL B1118 SHEET 1 AF4 2 LYS B 747 VAL B 750 0 SHEET 2 AF4 2 LEU B 872 LEU B 875 -1 O THR B 873 N SER B 749 SHEET 1 AF5 2 GLN B 801 ILE B 802 0 SHEET 2 AF5 2 ALA C 715 GLU C 716 1 O ALA C 715 N ILE B 802 SHEET 1 AF6 4 THR B1134 VAL B1136 0 SHEET 2 AF6 4 LYS B1100 PRO B1104 -1 N PHE B1103 O PHE B1135 SHEET 3 AF6 4 ILE B1095 HIS B1097 -1 N HIS B1097 O LYS B1100 SHEET 4 AF6 4 VAL B1147 ASN B1148 1 O VAL B1147 N CYS B1096 SHEET 1 AF7 4 THR P 3 SER P 7 0 SHEET 2 AF7 4 LEU P 18 SER P 25 -1 O THR P 21 N SER P 7 SHEET 3 AF7 4 GLN P 79 MET P 84 -1 O VAL P 80 N CYS P 22 SHEET 4 AF7 4 LEU P 69 ASP P 74 -1 N THR P 70 O THR P 83 SHEET 1 AF8 6 LEU P 11 VAL P 12 0 SHEET 2 AF8 6 THR P 122 VAL P 126 1 O THR P 125 N VAL P 12 SHEET 3 AF8 6 ALA P 93 SER P 102 -1 N TYR P 95 O THR P 122 SHEET 4 AF8 6 GLY P 35 GLN P 41 -1 N GLY P 35 O PHE P 100 SHEET 5 AF8 6 GLU P 48 ILE P 53 -1 O ILE P 53 N VAL P 36 SHEET 6 AF8 6 LYS P 59 SER P 61 -1 O ARG P 60 N LEU P 52 SHEET 1 AF9 4 LEU P 11 VAL P 12 0 SHEET 2 AF9 4 THR P 122 VAL P 126 1 O THR P 125 N VAL P 12 SHEET 3 AF9 4 ALA P 93 SER P 102 -1 N TYR P 95 O THR P 122 SHEET 4 AF9 4 SER P 113 TRP P 118 -1 O PRO P 117 N HIS P 99 SHEET 1 AG1 4 SER P 135 LEU P 139 0 SHEET 2 AG1 4 ALA P 151 TYR P 160 -1 O LYS P 158 N SER P 135 SHEET 3 AG1 4 TYR P 191 VAL P 199 -1 O LEU P 193 N VAL P 157 SHEET 4 AG1 4 HIS P 179 THR P 180 -1 N HIS P 179 O VAL P 196 SHEET 1 AG2 4 SER P 135 LEU P 139 0 SHEET 2 AG2 4 ALA P 151 TYR P 160 -1 O LYS P 158 N SER P 135 SHEET 3 AG2 4 TYR P 191 VAL P 199 -1 O LEU P 193 N VAL P 157 SHEET 4 AG2 4 VAL P 184 LEU P 185 -1 N VAL P 184 O SER P 192 SHEET 1 AG3 3 THR P 166 TRP P 169 0 SHEET 2 AG3 3 TYR P 209 HIS P 215 -1 O ASN P 212 N SER P 168 SHEET 3 AG3 3 THR P 220 VAL P 226 -1 O VAL P 222 N VAL P 213 SHEET 1 AG4 4 LEU Q 4 SER Q 7 0 SHEET 2 AG4 4 ALA Q 19 ALA Q 25 -1 O ARG Q 24 N THR Q 5 SHEET 3 AG4 4 ASP Q 71 ILE Q 76 -1 O ILE Q 76 N ALA Q 19 SHEET 4 AG4 4 PHE Q 63 SER Q 68 -1 N SER Q 64 O THR Q 75 SHEET 1 AG5 6 THR Q 10 SER Q 12 0 SHEET 2 AG5 6 THR Q 103 GLU Q 106 1 O GLU Q 106 N LEU Q 11 SHEET 3 AG5 6 VAL Q 86 GLN Q 91 -1 N TYR Q 87 O THR Q 103 SHEET 4 AG5 6 LEU Q 34 GLN Q 39 -1 N GLN Q 39 O VAL Q 86 SHEET 5 AG5 6 ARG Q 46 TYR Q 50 -1 O ARG Q 46 N GLN Q 38 SHEET 6 AG5 6 SER Q 54 ARG Q 55 -1 O SER Q 54 N TYR Q 50 SHEET 1 AG6 4 SER Q 115 PHE Q 119 0 SHEET 2 AG6 4 ALA Q 131 PHE Q 140 -1 O LEU Q 136 N PHE Q 117 SHEET 3 AG6 4 TYR Q 174 LEU Q 182 -1 O SER Q 178 N CYS Q 135 SHEET 4 AG6 4 SER Q 160 VAL Q 164 -1 N SER Q 163 O SER Q 177 SHEET 1 AG7 3 ALA Q 145 VAL Q 151 0 SHEET 2 AG7 3 VAL Q 192 HIS Q 199 -1 O THR Q 198 N LYS Q 146 SHEET 3 AG7 3 VAL Q 206 ASN Q 211 -1 O LYS Q 208 N CYS Q 195 SHEET 1 AG8 4 GLN E 3 SER E 7 0 SHEET 2 AG8 4 SER E 17 SER E 25 -1 O ALA E 23 N VAL E 5 SHEET 3 AG8 4 THR E 77 ASN E 83 -1 O MET E 82 N LEU E 18 SHEET 4 AG8 4 PHE E 67 ASP E 72 -1 N SER E 70 O TYR E 79 SHEET 1 AG9 6 GLY E 10 VAL E 12 0 SHEET 2 AG9 6 THR E 116 VAL E 120 1 O THR E 119 N VAL E 12 SHEET 3 AG9 6 ALA E 91 GLY E 100 -1 N TYR E 93 O THR E 116 SHEET 4 AG9 6 TYR E 33 GLN E 39 -1 N ASN E 35 O ALA E 96 SHEET 5 AG9 6 LEU E 45 VAL E 51 -1 O GLU E 46 N ARG E 38 SHEET 6 AG9 6 THR E 57 TYR E 59 -1 O PHE E 58 N VAL E 50 SHEET 1 AH1 4 GLY E 10 VAL E 12 0 SHEET 2 AH1 4 THR E 116 VAL E 120 1 O THR E 119 N VAL E 12 SHEET 3 AH1 4 ALA E 91 GLY E 100 -1 N TYR E 93 O THR E 116 SHEET 4 AH1 4 ALA E 105 TRP E 112 -1 O ALA E 108 N SER E 99 SHEET 1 AH2 4 SER E 129 LEU E 133 0 SHEET 2 AH2 4 ALA E 145 TYR E 154 -1 O LEU E 150 N PHE E 131 SHEET 3 AH2 4 TYR E 185 VAL E 193 -1 O LEU E 187 N VAL E 151 SHEET 4 AH2 4 VAL E 172 THR E 174 -1 N HIS E 173 O VAL E 190 SHEET 1 AH3 4 SER E 129 LEU E 133 0 SHEET 2 AH3 4 ALA E 145 TYR E 154 -1 O LEU E 150 N PHE E 131 SHEET 3 AH3 4 TYR E 185 VAL E 193 -1 O LEU E 187 N VAL E 151 SHEET 4 AH3 4 VAL E 178 LEU E 179 -1 N VAL E 178 O SER E 186 SHEET 1 AH4 3 THR E 160 TRP E 163 0 SHEET 2 AH4 3 TYR E 203 HIS E 209 -1 O ASN E 208 N THR E 160 SHEET 3 AH4 3 THR E 214 VAL E 220 -1 O VAL E 220 N TYR E 203 SHEET 1 AH5 4 MET F 4 SER F 7 0 SHEET 2 AH5 4 VAL F 19 ALA F 25 -1 O ARG F 24 N THR F 5 SHEET 3 AH5 4 ASP F 70 ILE F 75 -1 O LEU F 73 N ILE F 21 SHEET 4 AH5 4 PHE F 62 SER F 67 -1 N SER F 65 O THR F 72 SHEET 1 AH6 6 SER F 10 ALA F 13 0 SHEET 2 AH6 6 THR F 104 ILE F 108 1 O GLU F 107 N ALA F 13 SHEET 3 AH6 6 THR F 85 GLN F 90 -1 N TYR F 86 O THR F 104 SHEET 4 AH6 6 LEU F 33 GLN F 38 -1 N GLN F 38 O THR F 85 SHEET 5 AH6 6 LYS F 45 SER F 49 -1 O LYS F 45 N GLN F 37 SHEET 6 AH6 6 THR F 53 LEU F 54 -1 O THR F 53 N SER F 49 SHEET 1 AH7 4 SER F 116 PHE F 120 0 SHEET 2 AH7 4 THR F 131 PHE F 141 -1 O VAL F 135 N PHE F 120 SHEET 3 AH7 4 TYR F 175 SER F 184 -1 O LEU F 183 N ALA F 132 SHEET 4 AH7 4 SER F 161 THR F 166 -1 N GLN F 162 O THR F 180 SHEET 1 AH8 4 ALA F 155 GLN F 157 0 SHEET 2 AH8 4 ALA F 146 VAL F 152 -1 N TRP F 150 O GLN F 157 SHEET 3 AH8 4 VAL F 193 HIS F 200 -1 O ALA F 195 N LYS F 151 SHEET 4 AH8 4 VAL F 207 ASN F 212 -1 O PHE F 211 N TYR F 194 SHEET 1 AH9 7 THR C 45 ASN C 46 0 SHEET 2 AH9 7 ASN C 77 ALA C 83 -1 O VAL C 78 N THR C 45 SHEET 3 AH9 7 ALA C 277 TYR C 283 -1 O TYR C 279 N PHE C 81 SHEET 4 AH9 7 GLY C 103 GLU C 110 -1 N TYR C 105 O GLY C 282 SHEET 5 AH9 7 ASN C 202 ILE C 211 -1 O PHE C 206 N PHE C 106 SHEET 6 AH9 7 TYR C 214 PRO C 223 -1 O LYS C 220 N GLU C 205 SHEET 7 AH9 7 GLU C 238 PRO C 244 -1 O GLU C 238 N SER C 219 SHEET 1 AI1 3 LEU C 64 PHE C 71 0 SHEET 2 AI1 3 GLN C 285 TYR C 293 -1 O LEU C 291 N HIS C 65 SHEET 3 AI1 3 ILE C 299 ASP C 304 -1 O ASP C 301 N LYS C 292 SHEET 1 AI2 6 VAL C 97 PRO C 99 0 SHEET 2 AI2 6 ARG C 251 LEU C 255 -1 O PHE C 252 N LEU C 98 SHEET 3 AI2 6 GLY C 117 GLY C 121 -1 N GLY C 117 O LEU C 255 SHEET 4 AI2 6 SER C 130 ASN C 135 -1 O LEU C 131 N PHE C 120 SHEET 5 AI2 6 VAL C 140 CYS C 145 -1 O LYS C 143 N LEU C 132 SHEET 6 AI2 6 PHE C 182 SER C 186 -1 O TYR C 184 N ILE C 142 SHEET 1 AI3 2 PHE C 147 LEU C 155 0 SHEET 2 AI3 2 PHE C 171 ALA C 177 -1 O SER C 175 N GLN C 148 SHEET 1 AI4 5 GLY C 325 ARG C 333 0 SHEET 2 AI4 5 PHE C 606 THR C 613 -1 O VAL C 609 N SER C 330 SHEET 3 AI4 5 ALA C 623 GLN C 627 -1 O GLN C 627 N GLY C 608 SHEET 4 AI4 5 GLY C 662 ILE C 665 -1 O ILE C 665 N VAL C 624 SHEET 5 AI4 5 VAL C 656 GLN C 658 -1 N PHE C 657 O LEU C 664 SHEET 1 AI5 5 ASN C 368 ILE C 372 0 SHEET 2 AI5 5 VAL C 409 ILE C 416 -1 O VAL C 409 N ILE C 372 SHEET 3 AI5 5 TYR C 522 PHE C 529 -1 O VAL C 524 N PHE C 414 SHEET 4 AI5 5 GLY C 445 ASN C 451 -1 N CYS C 446 O LEU C 527 SHEET 5 AI5 5 ALA C 390 CYS C 393 -1 N LYS C 392 O VAL C 447 SHEET 1 AI6 2 ARG C 466 ARG C 468 0 SHEET 2 AI6 2 LEU C 506 SER C 508 -1 O GLN C 507 N TYR C 467 SHEET 1 AI7 2 TYR C 487 GLN C 488 0 SHEET 2 AI7 2 CYS C 502 TYR C 503 -1 O TYR C 503 N TYR C 487 SHEET 1 AI8 4 GLU C 668 TYR C 669 0 SHEET 2 AI8 4 ILE C 707 THR C 710 1 O ALA C 708 N GLU C 668 SHEET 3 AI8 4 ILE C 684 SER C 687 -1 N CYS C 685 O TYR C 709 SHEET 4 AI8 4 ILE C 678 GLY C 681 -1 N ILE C 678 O ALA C 686 SHEET 1 AI9 3 SER C 725 PRO C 742 0 SHEET 2 AI9 3 GLY C1073 ALA C1092 -1 O THR C1080 N SER C 735 SHEET 3 AI9 3 TYR C1061 ALA C1070 -1 N TYR C1061 O TYR C1081 SHEET 1 AJ1 5 SER C 725 PRO C 742 0 SHEET 2 AJ1 5 GLY C1073 ALA C1092 -1 O THR C1080 N SER C 735 SHEET 3 AJ1 5 VAL C1108 SER C1111 -1 O SER C1111 N THR C1090 SHEET 4 AJ1 5 TRP C1116 THR C1119 -1 O PHE C1117 N VAL C1110 SHEET 5 AJ1 5 GLN C1127 ILE C1128 -1 O GLN C1127 N VAL C1118 SHEET 1 AJ2 2 LYS C 747 VAL C 750 0 SHEET 2 AJ2 2 LEU C 872 LEU C 875 -1 O THR C 873 N SER C 749 SHEET 1 AJ3 4 THR C1134 VAL C1136 0 SHEET 2 AJ3 4 LYS C1100 PRO C1104 -1 N PHE C1103 O PHE C1135 SHEET 3 AJ3 4 ILE C1095 HIS C1097 -1 N HIS C1097 O LYS C1100 SHEET 4 AJ3 4 VAL C1147 ASN C1148 1 O VAL C1147 N CYS C1096 SHEET 1 AJ4 4 THR I 3 SER I 7 0 SHEET 2 AJ4 4 LEU I 18 SER I 25 -1 O THR I 21 N SER I 7 SHEET 3 AJ4 4 GLN I 79 MET I 84 -1 O VAL I 80 N CYS I 22 SHEET 4 AJ4 4 LEU I 69 ASP I 74 -1 N THR I 70 O THR I 83 SHEET 1 AJ5 6 LEU I 11 VAL I 12 0 SHEET 2 AJ5 6 THR I 122 VAL I 126 1 O THR I 125 N VAL I 12 SHEET 3 AJ5 6 ALA I 93 SER I 102 -1 N TYR I 95 O THR I 122 SHEET 4 AJ5 6 GLY I 35 GLN I 41 -1 N GLY I 35 O PHE I 100 SHEET 5 AJ5 6 GLU I 48 ILE I 53 -1 O ILE I 53 N VAL I 36 SHEET 6 AJ5 6 LYS I 59 SER I 61 -1 O ARG I 60 N LEU I 52 SHEET 1 AJ6 4 LEU I 11 VAL I 12 0 SHEET 2 AJ6 4 THR I 122 VAL I 126 1 O THR I 125 N VAL I 12 SHEET 3 AJ6 4 ALA I 93 SER I 102 -1 N TYR I 95 O THR I 122 SHEET 4 AJ6 4 SER I 113 TRP I 118 -1 O PRO I 117 N HIS I 99 SHEET 1 AJ7 4 SER I 135 LEU I 139 0 SHEET 2 AJ7 4 ALA I 151 TYR I 160 -1 O LYS I 158 N SER I 135 SHEET 3 AJ7 4 TYR I 191 VAL I 199 -1 O LEU I 193 N VAL I 157 SHEET 4 AJ7 4 HIS I 179 THR I 180 -1 N HIS I 179 O VAL I 196 SHEET 1 AJ8 4 SER I 135 LEU I 139 0 SHEET 2 AJ8 4 ALA I 151 TYR I 160 -1 O LYS I 158 N SER I 135 SHEET 3 AJ8 4 TYR I 191 VAL I 199 -1 O LEU I 193 N VAL I 157 SHEET 4 AJ8 4 VAL I 184 LEU I 185 -1 N VAL I 184 O SER I 192 SHEET 1 AJ9 3 THR I 166 TRP I 169 0 SHEET 2 AJ9 3 TYR I 209 HIS I 215 -1 O ASN I 212 N SER I 168 SHEET 3 AJ9 3 THR I 220 VAL I 226 -1 O VAL I 222 N VAL I 213 SHEET 1 AK1 4 LEU J 4 SER J 7 0 SHEET 2 AK1 4 ALA J 19 ALA J 25 -1 O ARG J 24 N THR J 5 SHEET 3 AK1 4 ASP J 71 ILE J 76 -1 O ILE J 76 N ALA J 19 SHEET 4 AK1 4 PHE J 63 SER J 68 -1 N SER J 64 O THR J 75 SHEET 1 AK2 6 THR J 10 SER J 12 0 SHEET 2 AK2 6 THR J 103 GLU J 106 1 O GLU J 106 N LEU J 11 SHEET 3 AK2 6 VAL J 86 GLN J 91 -1 N TYR J 87 O THR J 103 SHEET 4 AK2 6 LEU J 34 GLN J 39 -1 N GLN J 39 O VAL J 86 SHEET 5 AK2 6 ARG J 46 TYR J 50 -1 O ARG J 46 N GLN J 38 SHEET 6 AK2 6 SER J 54 ARG J 55 -1 O SER J 54 N TYR J 50 SHEET 1 AK3 4 SER J 115 PHE J 119 0 SHEET 2 AK3 4 ALA J 131 PHE J 140 -1 O LEU J 136 N PHE J 117 SHEET 3 AK3 4 TYR J 174 LEU J 182 -1 O SER J 178 N CYS J 135 SHEET 4 AK3 4 SER J 160 VAL J 164 -1 N SER J 163 O SER J 177 SHEET 1 AK4 3 ALA J 145 VAL J 151 0 SHEET 2 AK4 3 VAL J 192 HIS J 199 -1 O THR J 198 N LYS J 146 SHEET 3 AK4 3 VAL J 206 ASN J 211 -1 O LYS J 208 N CYS J 195 SHEET 1 AK5 4 GLN R 3 SER R 7 0 SHEET 2 AK5 4 SER R 17 SER R 25 -1 O ALA R 23 N VAL R 5 SHEET 3 AK5 4 THR R 77 ASN R 83 -1 O MET R 82 N LEU R 18 SHEET 4 AK5 4 PHE R 67 ASP R 72 -1 N SER R 70 O TYR R 79 SHEET 1 AK6 6 GLY R 10 VAL R 12 0 SHEET 2 AK6 6 THR R 116 VAL R 120 1 O THR R 119 N VAL R 12 SHEET 3 AK6 6 ALA R 91 GLY R 100 -1 N TYR R 93 O THR R 116 SHEET 4 AK6 6 TYR R 33 GLN R 39 -1 N ASN R 35 O ALA R 96 SHEET 5 AK6 6 LEU R 45 VAL R 51 -1 O GLU R 46 N ARG R 38 SHEET 6 AK6 6 THR R 57 TYR R 59 -1 O PHE R 58 N VAL R 50 SHEET 1 AK7 4 GLY R 10 VAL R 12 0 SHEET 2 AK7 4 THR R 116 VAL R 120 1 O THR R 119 N VAL R 12 SHEET 3 AK7 4 ALA R 91 GLY R 100 -1 N TYR R 93 O THR R 116 SHEET 4 AK7 4 ALA R 105 TRP R 112 -1 O ALA R 108 N SER R 99 SHEET 1 AK8 4 SER R 129 LEU R 133 0 SHEET 2 AK8 4 ALA R 145 TYR R 154 -1 O LEU R 150 N PHE R 131 SHEET 3 AK8 4 TYR R 185 VAL R 193 -1 O LEU R 187 N VAL R 151 SHEET 4 AK8 4 VAL R 172 THR R 174 -1 N HIS R 173 O VAL R 190 SHEET 1 AK9 4 SER R 129 LEU R 133 0 SHEET 2 AK9 4 ALA R 145 TYR R 154 -1 O LEU R 150 N PHE R 131 SHEET 3 AK9 4 TYR R 185 VAL R 193 -1 O LEU R 187 N VAL R 151 SHEET 4 AK9 4 VAL R 178 LEU R 179 -1 N VAL R 178 O SER R 186 SHEET 1 AL1 3 THR R 160 TRP R 163 0 SHEET 2 AL1 3 TYR R 203 HIS R 209 -1 O ASN R 208 N THR R 160 SHEET 3 AL1 3 THR R 214 VAL R 220 -1 O VAL R 220 N TYR R 203 SHEET 1 AL2 4 MET S 4 SER S 7 0 SHEET 2 AL2 4 VAL S 19 ALA S 25 -1 O ARG S 24 N THR S 5 SHEET 3 AL2 4 ASP S 70 ILE S 75 -1 O LEU S 73 N ILE S 21 SHEET 4 AL2 4 PHE S 62 SER S 67 -1 N SER S 65 O THR S 72 SHEET 1 AL3 6 SER S 10 ALA S 13 0 SHEET 2 AL3 6 THR S 104 ILE S 108 1 O GLU S 107 N ALA S 13 SHEET 3 AL3 6 THR S 85 GLN S 90 -1 N TYR S 86 O THR S 104 SHEET 4 AL3 6 LEU S 33 GLN S 38 -1 N GLN S 38 O THR S 85 SHEET 5 AL3 6 LYS S 45 SER S 49 -1 O LYS S 45 N GLN S 37 SHEET 6 AL3 6 THR S 53 LEU S 54 -1 O THR S 53 N SER S 49 SHEET 1 AL4 4 SER S 116 PHE S 120 0 SHEET 2 AL4 4 THR S 131 PHE S 141 -1 O VAL S 135 N PHE S 120 SHEET 3 AL4 4 TYR S 175 SER S 184 -1 O LEU S 183 N ALA S 132 SHEET 4 AL4 4 SER S 161 THR S 166 -1 N GLN S 162 O THR S 180 SHEET 1 AL5 4 ALA S 155 GLN S 157 0 SHEET 2 AL5 4 ALA S 146 VAL S 152 -1 N TRP S 150 O GLN S 157 SHEET 3 AL5 4 VAL S 193 HIS S 200 -1 O ALA S 195 N LYS S 151 SHEET 4 AL5 4 VAL S 207 ASN S 212 -1 O PHE S 211 N TYR S 194 SSBOND 1 CYS A 34 CYS A 150 1555 1555 2.03 SSBOND 2 CYS A 145 CYS A 180 1555 1555 2.03 SSBOND 3 CYS A 305 CYS A 315 1555 1555 2.03 SSBOND 4 CYS A 350 CYS A 375 1555 1555 2.03 SSBOND 5 CYS A 393 CYS A 446 1555 1555 2.04 SSBOND 6 CYS A 405 CYS A 539 1555 1555 2.03 SSBOND 7 CYS A 494 CYS A 502 1555 1555 2.03 SSBOND 8 CYS A 552 CYS A 604 1555 1555 2.02 SSBOND 9 CYS A 631 CYS A 663 1555 1555 2.03 SSBOND 10 CYS A 676 CYS A 685 1555 1555 2.03 SSBOND 11 CYS A 752 CYS A 774 1555 1555 2.03 SSBOND 12 CYS A 757 CYS A 763 1555 1555 2.03 SSBOND 13 CYS A 1046 CYS A 1057 1555 1555 2.03 SSBOND 14 CYS A 1096 CYS A 1140 1555 1555 2.03 SSBOND 15 CYS H 22 CYS H 97 1555 1555 2.03 SSBOND 16 CYS H 155 CYS H 211 1555 1555 2.04 SSBOND 17 CYS H 231 CYS L 215 1555 1555 2.03 SSBOND 18 CYS L 23 CYS L 89 1555 1555 2.04 SSBOND 19 CYS L 135 CYS L 195 1555 1555 2.04 SSBOND 20 CYS M 22 CYS M 95 1555 1555 2.03 SSBOND 21 CYS M 149 CYS M 205 1555 1555 2.04 SSBOND 22 CYS M 225 CYS N 216 1555 1555 2.03 SSBOND 23 CYS N 23 CYS N 88 1555 1555 2.04 SSBOND 24 CYS N 136 CYS N 196 1555 1555 2.04 SSBOND 25 CYS B 34 CYS B 150 1555 1555 2.03 SSBOND 26 CYS B 145 CYS B 180 1555 1555 2.03 SSBOND 27 CYS B 305 CYS B 315 1555 1555 2.03 SSBOND 28 CYS B 350 CYS B 375 1555 1555 2.03 SSBOND 29 CYS B 393 CYS B 446 1555 1555 2.04 SSBOND 30 CYS B 405 CYS B 539 1555 1555 2.03 SSBOND 31 CYS B 494 CYS B 502 1555 1555 2.03 SSBOND 32 CYS B 552 CYS B 604 1555 1555 2.03 SSBOND 33 CYS B 631 CYS B 663 1555 1555 2.03 SSBOND 34 CYS B 676 CYS B 685 1555 1555 2.03 SSBOND 35 CYS B 752 CYS B 774 1555 1555 2.03 SSBOND 36 CYS B 757 CYS B 763 1555 1555 2.03 SSBOND 37 CYS B 1046 CYS B 1057 1555 1555 2.03 SSBOND 38 CYS B 1096 CYS B 1140 1555 1555 2.03 SSBOND 39 CYS P 22 CYS P 97 1555 1555 2.03 SSBOND 40 CYS P 155 CYS P 211 1555 1555 2.04 SSBOND 41 CYS P 231 CYS Q 215 1555 1555 2.03 SSBOND 42 CYS Q 23 CYS Q 89 1555 1555 2.04 SSBOND 43 CYS Q 135 CYS Q 195 1555 1555 2.04 SSBOND 44 CYS E 22 CYS E 95 1555 1555 2.03 SSBOND 45 CYS E 149 CYS E 205 1555 1555 2.04 SSBOND 46 CYS E 225 CYS F 216 1555 1555 2.03 SSBOND 47 CYS F 23 CYS F 88 1555 1555 2.04 SSBOND 48 CYS F 136 CYS F 196 1555 1555 2.04 SSBOND 49 CYS C 34 CYS C 150 1555 1555 2.03 SSBOND 50 CYS C 145 CYS C 180 1555 1555 2.03 SSBOND 51 CYS C 305 CYS C 315 1555 1555 2.03 SSBOND 52 CYS C 350 CYS C 375 1555 1555 2.03 SSBOND 53 CYS C 393 CYS C 446 1555 1555 2.04 SSBOND 54 CYS C 405 CYS C 539 1555 1555 2.03 SSBOND 55 CYS C 494 CYS C 502 1555 1555 2.03 SSBOND 56 CYS C 552 CYS C 604 1555 1555 2.03 SSBOND 57 CYS C 631 CYS C 663 1555 1555 2.03 SSBOND 58 CYS C 676 CYS C 685 1555 1555 2.03 SSBOND 59 CYS C 752 CYS C 774 1555 1555 2.03 SSBOND 60 CYS C 757 CYS C 763 1555 1555 2.03 SSBOND 61 CYS C 1046 CYS C 1057 1555 1555 2.03 SSBOND 62 CYS C 1096 CYS C 1140 1555 1555 2.03 SSBOND 63 CYS I 22 CYS I 97 1555 1555 2.03 SSBOND 64 CYS I 155 CYS I 211 1555 1555 2.04 SSBOND 65 CYS I 231 CYS J 215 1555 1555 2.03 SSBOND 66 CYS J 23 CYS J 89 1555 1555 2.04 SSBOND 67 CYS J 135 CYS J 195 1555 1555 2.04 SSBOND 68 CYS R 22 CYS R 95 1555 1555 2.03 SSBOND 69 CYS R 149 CYS R 205 1555 1555 2.04 SSBOND 70 CYS R 225 CYS S 216 1555 1555 2.03 SSBOND 71 CYS S 23 CYS S 88 1555 1555 2.04 SSBOND 72 CYS S 136 CYS S 196 1555 1555 2.04 LINK ND2 ASN A 357 C1 NAG A1201 1555 1555 1.44 LINK ND2 ASN B 357 C1 NAG B1201 1555 1555 1.44 LINK ND2 ASN C 357 C1 NAG C1201 1555 1555 1.44 CISPEP 1 PHE H 161 PRO H 162 0 -7.56 CISPEP 2 GLU H 163 PRO H 164 0 -11.33 CISPEP 3 SER L 7 PRO L 8 0 -3.41 CISPEP 4 SER L 95 PRO L 96 0 -2.63 CISPEP 5 TYR L 141 PRO L 142 0 1.85 CISPEP 6 PHE M 155 PRO M 156 0 -4.48 CISPEP 7 GLU M 157 PRO M 158 0 -3.29 CISPEP 8 SER N 7 PRO N 8 0 -4.73 CISPEP 9 TYR N 142 PRO N 143 0 -1.81 CISPEP 10 PHE P 161 PRO P 162 0 -7.52 CISPEP 11 GLU P 163 PRO P 164 0 -11.43 CISPEP 12 SER Q 7 PRO Q 8 0 -3.37 CISPEP 13 SER Q 95 PRO Q 96 0 -2.62 CISPEP 14 TYR Q 141 PRO Q 142 0 1.76 CISPEP 15 PHE E 155 PRO E 156 0 -4.50 CISPEP 16 GLU E 157 PRO E 158 0 -3.36 CISPEP 17 SER F 7 PRO F 8 0 -4.83 CISPEP 18 TYR F 142 PRO F 143 0 -1.72 CISPEP 19 PHE I 161 PRO I 162 0 -7.62 CISPEP 20 GLU I 163 PRO I 164 0 -11.43 CISPEP 21 SER J 7 PRO J 8 0 -3.52 CISPEP 22 SER J 95 PRO J 96 0 -2.63 CISPEP 23 TYR J 141 PRO J 142 0 1.81 CISPEP 24 PHE R 155 PRO R 156 0 -4.46 CISPEP 25 GLU R 157 PRO R 158 0 -3.31 CISPEP 26 SER S 7 PRO S 8 0 -4.70 CISPEP 27 TYR S 142 PRO S 143 0 -1.79 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000