HEADER VIRAL PROTEIN 19-FEB-23 8IFN TITLE MERS-COV SPIKE TRIMER IN COMPLEX WITH NANOBODY VHH-T148 COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: B, C, E; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: VHH-T148; COMPND 8 CHAIN: A, D, F; COMPND 9 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MIDDLE EAST RESPIRATORY SYNDROME-RELATED SOURCE 3 CORONAVIRUS; SOURCE 4 ORGANISM_TAXID: 1335626; SOURCE 5 EXPRESSION_SYSTEM: TRICHOPLUSIA NI; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 7111; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; SOURCE 9 ORGANISM_TAXID: 9838; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS MERS-COV, NANOBODY, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX, VIRAL KEYWDS 2 PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR X.WANG,L.TIAN REVDAT 1 28-FEB-24 8IFN 0 JRNL AUTH L.TIAN,R.WANG,L.ZHANG,X.WANG JRNL TITL STRUCTURES AND NEUTRALIZING MECHANISMS OF CAMEL NANOBODIES JRNL TITL 2 TARGETING THE RECEPTOR-BINDING DOMAIN OF MERS-COV SPIKE JRNL TITL 3 GLYCOPROTEIN JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.81 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.810 REMARK 3 NUMBER OF PARTICLES : 216306 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8IFN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 21-FEB-23. REMARK 100 THE DEPOSITION ID IS D_1300035525. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : MERS-COV SPIKE TRIMER IN REMARK 245 COMPLEX WITH NANOBODY VHH-T148 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1800.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, A, C, D, E, F, G, H, I REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET B 1 REMARK 465 ILE B 2 REMARK 465 HIS B 3 REMARK 465 SER B 4 REMARK 465 VAL B 5 REMARK 465 PHE B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 MET B 9 REMARK 465 PHE B 10 REMARK 465 LEU B 11 REMARK 465 LEU B 12 REMARK 465 THR B 13 REMARK 465 PRO B 14 REMARK 465 THR B 15 REMARK 465 GLU B 16 REMARK 465 SER B 17 REMARK 465 ASP B 701 REMARK 465 SER B 702 REMARK 465 THR B 703 REMARK 465 TYR B 704 REMARK 465 PRO B 742 REMARK 465 SER B 743 REMARK 465 THR B 744 REMARK 465 LEU B 745 REMARK 465 THR B 746 REMARK 465 PRO B 747 REMARK 465 SER B 748 REMARK 465 SER B 749 REMARK 465 VAL B 750 REMARK 465 GLY B 751 REMARK 465 SER B 752 REMARK 465 SER B 878 REMARK 465 ILE B 879 REMARK 465 SER B 880 REMARK 465 THR B 881 REMARK 465 GLY B 882 REMARK 465 SER B 883 REMARK 465 ARG B 884 REMARK 465 SER B 885 REMARK 465 THR B 1178 REMARK 465 ARG B 1179 REMARK 465 ILE B 1180 REMARK 465 VAL B 1181 REMARK 465 ASN B 1225 REMARK 465 SER B 1226 REMARK 465 THR B 1227 REMARK 465 GLY B 1228 REMARK 465 ILE B 1229 REMARK 465 ASP B 1230 REMARK 465 PHE B 1231 REMARK 465 GLN B 1232 REMARK 465 ASP B 1233 REMARK 465 GLU B 1234 REMARK 465 LEU B 1235 REMARK 465 ASP B 1236 REMARK 465 GLU B 1237 REMARK 465 PHE B 1238 REMARK 465 PHE B 1239 REMARK 465 LYS B 1240 REMARK 465 ASN B 1241 REMARK 465 VAL B 1242 REMARK 465 SER B 1243 REMARK 465 THR B 1244 REMARK 465 SER B 1245 REMARK 465 ILE B 1246 REMARK 465 PRO B 1247 REMARK 465 ASN B 1248 REMARK 465 PHE B 1249 REMARK 465 GLY B 1250 REMARK 465 SER B 1251 REMARK 465 LEU B 1252 REMARK 465 THR B 1253 REMARK 465 GLN B 1254 REMARK 465 ILE B 1255 REMARK 465 ASN B 1256 REMARK 465 THR B 1257 REMARK 465 THR B 1258 REMARK 465 LEU B 1259 REMARK 465 LEU B 1260 REMARK 465 ASP B 1261 REMARK 465 LEU B 1262 REMARK 465 THR B 1263 REMARK 465 TYR B 1264 REMARK 465 GLU B 1265 REMARK 465 MET B 1266 REMARK 465 LEU B 1267 REMARK 465 SER B 1268 REMARK 465 LEU B 1269 REMARK 465 GLN B 1270 REMARK 465 GLN B 1271 REMARK 465 VAL B 1272 REMARK 465 VAL B 1273 REMARK 465 LYS B 1274 REMARK 465 ALA B 1275 REMARK 465 LEU B 1276 REMARK 465 ASN B 1277 REMARK 465 GLU B 1278 REMARK 465 SER B 1279 REMARK 465 TYR B 1280 REMARK 465 ILE B 1281 REMARK 465 ASP B 1282 REMARK 465 LEU B 1283 REMARK 465 LYS B 1284 REMARK 465 GLU B 1285 REMARK 465 LEU B 1286 REMARK 465 GLY B 1287 REMARK 465 ASN B 1288 REMARK 465 TYR B 1289 REMARK 465 THR B 1290 REMARK 465 SER B 1291 REMARK 465 ARG B 1292 REMARK 465 GLU B 1293 REMARK 465 ASN B 1294 REMARK 465 LEU B 1295 REMARK 465 TYR B 1296 REMARK 465 PHE B 1297 REMARK 465 GLN B 1298 REMARK 465 GLY B 1299 REMARK 465 GLY B 1300 REMARK 465 GLY B 1301 REMARK 465 SER B 1302 REMARK 465 ALA B 1303 REMARK 465 GLY B 1304 REMARK 465 SER B 1305 REMARK 465 GLY B 1306 REMARK 465 TYR B 1307 REMARK 465 ILE B 1308 REMARK 465 PRO B 1309 REMARK 465 GLU B 1310 REMARK 465 ALA B 1311 REMARK 465 PRO B 1312 REMARK 465 ARG B 1313 REMARK 465 ASP B 1314 REMARK 465 GLY B 1315 REMARK 465 GLN B 1316 REMARK 465 ALA B 1317 REMARK 465 TYR B 1318 REMARK 465 VAL B 1319 REMARK 465 ARG B 1320 REMARK 465 LYS B 1321 REMARK 465 ASP B 1322 REMARK 465 GLY B 1323 REMARK 465 GLU B 1324 REMARK 465 TRP B 1325 REMARK 465 VAL B 1326 REMARK 465 LEU B 1327 REMARK 465 LEU B 1328 REMARK 465 SER B 1329 REMARK 465 THR B 1330 REMARK 465 PHE B 1331 REMARK 465 LEU B 1332 REMARK 465 GLY B 1333 REMARK 465 HIS B 1334 REMARK 465 HIS B 1335 REMARK 465 HIS B 1336 REMARK 465 HIS B 1337 REMARK 465 HIS B 1338 REMARK 465 HIS B 1339 REMARK 465 TRP B 1340 REMARK 465 SER B 1341 REMARK 465 HIS B 1342 REMARK 465 PRO B 1343 REMARK 465 GLN B 1344 REMARK 465 PHE B 1345 REMARK 465 GLU B 1346 REMARK 465 LYS B 1347 REMARK 465 SER A 129 REMARK 465 HIS A 130 REMARK 465 HIS A 131 REMARK 465 HIS A 132 REMARK 465 HIS A 133 REMARK 465 HIS A 134 REMARK 465 HIS A 135 REMARK 465 MET C 1 REMARK 465 ILE C 2 REMARK 465 HIS C 3 REMARK 465 SER C 4 REMARK 465 VAL C 5 REMARK 465 PHE C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 MET C 9 REMARK 465 PHE C 10 REMARK 465 LEU C 11 REMARK 465 LEU C 12 REMARK 465 THR C 13 REMARK 465 PRO C 14 REMARK 465 THR C 15 REMARK 465 GLU C 16 REMARK 465 SER C 17 REMARK 465 ASP C 701 REMARK 465 SER C 702 REMARK 465 THR C 703 REMARK 465 TYR C 704 REMARK 465 PRO C 742 REMARK 465 SER C 743 REMARK 465 THR C 744 REMARK 465 LEU C 745 REMARK 465 THR C 746 REMARK 465 PRO C 747 REMARK 465 SER C 748 REMARK 465 SER C 749 REMARK 465 VAL C 750 REMARK 465 GLY C 751 REMARK 465 SER C 752 REMARK 465 SER C 878 REMARK 465 ILE C 879 REMARK 465 SER C 880 REMARK 465 THR C 881 REMARK 465 GLY C 882 REMARK 465 SER C 883 REMARK 465 ARG C 884 REMARK 465 SER C 885 REMARK 465 THR C 1178 REMARK 465 ARG C 1179 REMARK 465 ILE C 1180 REMARK 465 VAL C 1181 REMARK 465 ASN C 1225 REMARK 465 SER C 1226 REMARK 465 THR C 1227 REMARK 465 GLY C 1228 REMARK 465 ILE C 1229 REMARK 465 ASP C 1230 REMARK 465 PHE C 1231 REMARK 465 GLN C 1232 REMARK 465 ASP C 1233 REMARK 465 GLU C 1234 REMARK 465 LEU C 1235 REMARK 465 ASP C 1236 REMARK 465 GLU C 1237 REMARK 465 PHE C 1238 REMARK 465 PHE C 1239 REMARK 465 LYS C 1240 REMARK 465 ASN C 1241 REMARK 465 VAL C 1242 REMARK 465 SER C 1243 REMARK 465 THR C 1244 REMARK 465 SER C 1245 REMARK 465 ILE C 1246 REMARK 465 PRO C 1247 REMARK 465 ASN C 1248 REMARK 465 PHE C 1249 REMARK 465 GLY C 1250 REMARK 465 SER C 1251 REMARK 465 LEU C 1252 REMARK 465 THR C 1253 REMARK 465 GLN C 1254 REMARK 465 ILE C 1255 REMARK 465 ASN C 1256 REMARK 465 THR C 1257 REMARK 465 THR C 1258 REMARK 465 LEU C 1259 REMARK 465 LEU C 1260 REMARK 465 ASP C 1261 REMARK 465 LEU C 1262 REMARK 465 THR C 1263 REMARK 465 TYR C 1264 REMARK 465 GLU C 1265 REMARK 465 MET C 1266 REMARK 465 LEU C 1267 REMARK 465 SER C 1268 REMARK 465 LEU C 1269 REMARK 465 GLN C 1270 REMARK 465 GLN C 1271 REMARK 465 VAL C 1272 REMARK 465 VAL C 1273 REMARK 465 LYS C 1274 REMARK 465 ALA C 1275 REMARK 465 LEU C 1276 REMARK 465 ASN C 1277 REMARK 465 GLU C 1278 REMARK 465 SER C 1279 REMARK 465 TYR C 1280 REMARK 465 ILE C 1281 REMARK 465 ASP C 1282 REMARK 465 LEU C 1283 REMARK 465 LYS C 1284 REMARK 465 GLU C 1285 REMARK 465 LEU C 1286 REMARK 465 GLY C 1287 REMARK 465 ASN C 1288 REMARK 465 TYR C 1289 REMARK 465 THR C 1290 REMARK 465 SER C 1291 REMARK 465 ARG C 1292 REMARK 465 GLU C 1293 REMARK 465 ASN C 1294 REMARK 465 LEU C 1295 REMARK 465 TYR C 1296 REMARK 465 PHE C 1297 REMARK 465 GLN C 1298 REMARK 465 GLY C 1299 REMARK 465 GLY C 1300 REMARK 465 GLY C 1301 REMARK 465 SER C 1302 REMARK 465 ALA C 1303 REMARK 465 GLY C 1304 REMARK 465 SER C 1305 REMARK 465 GLY C 1306 REMARK 465 TYR C 1307 REMARK 465 ILE C 1308 REMARK 465 PRO C 1309 REMARK 465 GLU C 1310 REMARK 465 ALA C 1311 REMARK 465 PRO C 1312 REMARK 465 ARG C 1313 REMARK 465 ASP C 1314 REMARK 465 GLY C 1315 REMARK 465 GLN C 1316 REMARK 465 ALA C 1317 REMARK 465 TYR C 1318 REMARK 465 VAL C 1319 REMARK 465 ARG C 1320 REMARK 465 LYS C 1321 REMARK 465 ASP C 1322 REMARK 465 GLY C 1323 REMARK 465 GLU C 1324 REMARK 465 TRP C 1325 REMARK 465 VAL C 1326 REMARK 465 LEU C 1327 REMARK 465 LEU C 1328 REMARK 465 SER C 1329 REMARK 465 THR C 1330 REMARK 465 PHE C 1331 REMARK 465 LEU C 1332 REMARK 465 GLY C 1333 REMARK 465 HIS C 1334 REMARK 465 HIS C 1335 REMARK 465 HIS C 1336 REMARK 465 HIS C 1337 REMARK 465 HIS C 1338 REMARK 465 HIS C 1339 REMARK 465 TRP C 1340 REMARK 465 SER C 1341 REMARK 465 HIS C 1342 REMARK 465 PRO C 1343 REMARK 465 GLN C 1344 REMARK 465 PHE C 1345 REMARK 465 GLU C 1346 REMARK 465 LYS C 1347 REMARK 465 SER D 129 REMARK 465 HIS D 130 REMARK 465 HIS D 131 REMARK 465 HIS D 132 REMARK 465 HIS D 133 REMARK 465 HIS D 134 REMARK 465 HIS D 135 REMARK 465 MET E 1 REMARK 465 ILE E 2 REMARK 465 HIS E 3 REMARK 465 SER E 4 REMARK 465 VAL E 5 REMARK 465 PHE E 6 REMARK 465 LEU E 7 REMARK 465 LEU E 8 REMARK 465 MET E 9 REMARK 465 PHE E 10 REMARK 465 LEU E 11 REMARK 465 LEU E 12 REMARK 465 THR E 13 REMARK 465 PRO E 14 REMARK 465 THR E 15 REMARK 465 GLU E 16 REMARK 465 SER E 17 REMARK 465 ASP E 701 REMARK 465 SER E 702 REMARK 465 THR E 703 REMARK 465 TYR E 704 REMARK 465 PRO E 742 REMARK 465 SER E 743 REMARK 465 THR E 744 REMARK 465 LEU E 745 REMARK 465 THR E 746 REMARK 465 PRO E 747 REMARK 465 SER E 748 REMARK 465 SER E 749 REMARK 465 VAL E 750 REMARK 465 GLY E 751 REMARK 465 SER E 752 REMARK 465 SER E 878 REMARK 465 ILE E 879 REMARK 465 SER E 880 REMARK 465 THR E 881 REMARK 465 GLY E 882 REMARK 465 SER E 883 REMARK 465 ARG E 884 REMARK 465 SER E 885 REMARK 465 THR E 1178 REMARK 465 ARG E 1179 REMARK 465 ILE E 1180 REMARK 465 VAL E 1181 REMARK 465 ASN E 1225 REMARK 465 SER E 1226 REMARK 465 THR E 1227 REMARK 465 GLY E 1228 REMARK 465 ILE E 1229 REMARK 465 ASP E 1230 REMARK 465 PHE E 1231 REMARK 465 GLN E 1232 REMARK 465 ASP E 1233 REMARK 465 GLU E 1234 REMARK 465 LEU E 1235 REMARK 465 ASP E 1236 REMARK 465 GLU E 1237 REMARK 465 PHE E 1238 REMARK 465 PHE E 1239 REMARK 465 LYS E 1240 REMARK 465 ASN E 1241 REMARK 465 VAL E 1242 REMARK 465 SER E 1243 REMARK 465 THR E 1244 REMARK 465 SER E 1245 REMARK 465 ILE E 1246 REMARK 465 PRO E 1247 REMARK 465 ASN E 1248 REMARK 465 PHE E 1249 REMARK 465 GLY E 1250 REMARK 465 SER E 1251 REMARK 465 LEU E 1252 REMARK 465 THR E 1253 REMARK 465 GLN E 1254 REMARK 465 ILE E 1255 REMARK 465 ASN E 1256 REMARK 465 THR E 1257 REMARK 465 THR E 1258 REMARK 465 LEU E 1259 REMARK 465 LEU E 1260 REMARK 465 ASP E 1261 REMARK 465 LEU E 1262 REMARK 465 THR E 1263 REMARK 465 TYR E 1264 REMARK 465 GLU E 1265 REMARK 465 MET E 1266 REMARK 465 LEU E 1267 REMARK 465 SER E 1268 REMARK 465 LEU E 1269 REMARK 465 GLN E 1270 REMARK 465 GLN E 1271 REMARK 465 VAL E 1272 REMARK 465 VAL E 1273 REMARK 465 LYS E 1274 REMARK 465 ALA E 1275 REMARK 465 LEU E 1276 REMARK 465 ASN E 1277 REMARK 465 GLU E 1278 REMARK 465 SER E 1279 REMARK 465 TYR E 1280 REMARK 465 ILE E 1281 REMARK 465 ASP E 1282 REMARK 465 LEU E 1283 REMARK 465 LYS E 1284 REMARK 465 GLU E 1285 REMARK 465 LEU E 1286 REMARK 465 GLY E 1287 REMARK 465 ASN E 1288 REMARK 465 TYR E 1289 REMARK 465 THR E 1290 REMARK 465 SER E 1291 REMARK 465 ARG E 1292 REMARK 465 GLU E 1293 REMARK 465 ASN E 1294 REMARK 465 LEU E 1295 REMARK 465 TYR E 1296 REMARK 465 PHE E 1297 REMARK 465 GLN E 1298 REMARK 465 GLY E 1299 REMARK 465 GLY E 1300 REMARK 465 GLY E 1301 REMARK 465 SER E 1302 REMARK 465 ALA E 1303 REMARK 465 GLY E 1304 REMARK 465 SER E 1305 REMARK 465 GLY E 1306 REMARK 465 TYR E 1307 REMARK 465 ILE E 1308 REMARK 465 PRO E 1309 REMARK 465 GLU E 1310 REMARK 465 ALA E 1311 REMARK 465 PRO E 1312 REMARK 465 ARG E 1313 REMARK 465 ASP E 1314 REMARK 465 GLY E 1315 REMARK 465 GLN E 1316 REMARK 465 ALA E 1317 REMARK 465 TYR E 1318 REMARK 465 VAL E 1319 REMARK 465 ARG E 1320 REMARK 465 LYS E 1321 REMARK 465 ASP E 1322 REMARK 465 GLY E 1323 REMARK 465 GLU E 1324 REMARK 465 TRP E 1325 REMARK 465 VAL E 1326 REMARK 465 LEU E 1327 REMARK 465 LEU E 1328 REMARK 465 SER E 1329 REMARK 465 THR E 1330 REMARK 465 PHE E 1331 REMARK 465 LEU E 1332 REMARK 465 GLY E 1333 REMARK 465 HIS E 1334 REMARK 465 HIS E 1335 REMARK 465 HIS E 1336 REMARK 465 HIS E 1337 REMARK 465 HIS E 1338 REMARK 465 HIS E 1339 REMARK 465 TRP E 1340 REMARK 465 SER E 1341 REMARK 465 HIS E 1342 REMARK 465 PRO E 1343 REMARK 465 GLN E 1344 REMARK 465 PHE E 1345 REMARK 465 GLU E 1346 REMARK 465 LYS E 1347 REMARK 465 SER F 129 REMARK 465 HIS F 130 REMARK 465 HIS F 131 REMARK 465 HIS F 132 REMARK 465 HIS F 133 REMARK 465 HIS F 134 REMARK 465 HIS F 135 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 NH1 ARG E 511 C6 NAG G 2 1.32 REMARK 500 NH1 ARG B 511 C6 NAG H 2 1.32 REMARK 500 NH1 ARG C 511 C6 NAG I 2 1.32 REMARK 500 NH1 ARG B 511 C5 NAG H 2 1.43 REMARK 500 NH1 ARG C 511 C5 NAG I 2 1.43 REMARK 500 NH1 ARG E 511 C5 NAG G 2 1.43 REMARK 500 NH1 ARG B 511 O5 NAG H 2 1.59 REMARK 500 NH1 ARG C 511 O5 NAG I 2 1.59 REMARK 500 NH1 ARG E 511 O5 NAG G 2 1.60 REMARK 500 NH1 ARG C 511 C4 NAG I 2 2.18 REMARK 500 O ALA B 92 NE2 GLN B 304 2.18 REMARK 500 O ALA E 92 NE2 GLN E 304 2.18 REMARK 500 O ALA C 92 NE2 GLN C 304 2.18 REMARK 500 NH1 ARG B 511 C4 NAG H 2 2.18 REMARK 500 NH1 ARG E 511 C4 NAG G 2 2.18 REMARK 500 OH TYR C 58 O GLY C 331 2.19 REMARK 500 OH TYR B 58 O GLY B 331 2.19 REMARK 500 OH TYR E 58 O GLY E 331 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS B 185 CA - CB - SG ANGL. DEV. = 14.2 DEGREES REMARK 500 CYS B 237 CA - CB - SG ANGL. DEV. = 16.0 DEGREES REMARK 500 CYS B 620 CA - CB - SG ANGL. DEV. = 10.2 DEGREES REMARK 500 CYS B 650 CA - CB - SG ANGL. DEV. = 6.8 DEGREES REMARK 500 CYS B 736 CA - CB - SG ANGL. DEV. = 7.5 DEGREES REMARK 500 MET B 913 CA - CB - CG ANGL. DEV. = 16.0 DEGREES REMARK 500 MET B 913 CB - CG - SD ANGL. DEV. = 25.9 DEGREES REMARK 500 MET B 913 CG - SD - CE ANGL. DEV. = 9.9 DEGREES REMARK 500 CYS C 185 CA - CB - SG ANGL. DEV. = 14.2 DEGREES REMARK 500 CYS C 237 CA - CB - SG ANGL. DEV. = 16.0 DEGREES REMARK 500 CYS C 620 CA - CB - SG ANGL. DEV. = 10.1 DEGREES REMARK 500 CYS C 650 CA - CB - SG ANGL. DEV. = 6.9 DEGREES REMARK 500 CYS C 736 CA - CB - SG ANGL. DEV. = 7.5 DEGREES REMARK 500 MET C 913 CA - CB - CG ANGL. DEV. = 16.1 DEGREES REMARK 500 MET C 913 CB - CG - SD ANGL. DEV. = 25.9 DEGREES REMARK 500 MET C 913 CG - SD - CE ANGL. DEV. = 9.8 DEGREES REMARK 500 CYS E 185 CA - CB - SG ANGL. DEV. = 14.2 DEGREES REMARK 500 CYS E 237 CA - CB - SG ANGL. DEV. = 16.0 DEGREES REMARK 500 CYS E 620 CA - CB - SG ANGL. DEV. = 10.2 DEGREES REMARK 500 CYS E 650 CA - CB - SG ANGL. DEV. = 6.8 DEGREES REMARK 500 CYS E 736 CA - CB - SG ANGL. DEV. = 7.5 DEGREES REMARK 500 MET E 913 CA - CB - CG ANGL. DEV. = 16.1 DEGREES REMARK 500 MET E 913 CB - CG - SD ANGL. DEV. = 25.9 DEGREES REMARK 500 MET E 913 CG - SD - CE ANGL. DEV. = 9.9 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN B 104 37.36 -96.71 REMARK 500 PHE B 165 -64.13 -96.01 REMARK 500 SER B 224 -4.43 73.97 REMARK 500 ASN B 236 66.60 60.60 REMARK 500 MET B 240 88.03 -152.36 REMARK 500 TYR B 270 -12.13 74.55 REMARK 500 VAL B 271 -56.02 -130.52 REMARK 500 TYR B 351 -7.08 72.15 REMARK 500 GLU B 357 -172.96 -68.19 REMARK 500 GLN B 377 -174.44 -171.99 REMARK 500 LEU B 417 0.73 -67.42 REMARK 500 MET B 452 40.01 -98.32 REMARK 500 SER B 460 67.33 60.13 REMARK 500 SER B 474 -60.62 -90.46 REMARK 500 ASP B 510 10.11 58.78 REMARK 500 MET B 563 177.82 -59.97 REMARK 500 PHE B 590 59.64 -94.25 REMARK 500 ALA B 591 32.74 -142.23 REMARK 500 GLN B 599 58.78 -95.69 REMARK 500 TYR B 609 -151.55 -149.71 REMARK 500 GLN B 636 61.56 62.72 REMARK 500 ALA B 653 80.03 61.14 REMARK 500 CYS B 654 138.46 -34.07 REMARK 500 SER B 676 75.17 -105.56 REMARK 500 SER B 721 32.86 -97.41 REMARK 500 CYS B 727 19.17 -140.91 REMARK 500 LYS B 728 -5.62 66.68 REMARK 500 SER B 781 68.87 60.06 REMARK 500 THR B 784 44.28 -142.81 REMARK 500 PHE B 786 -61.37 -90.08 REMARK 500 GLN B 792 73.33 64.66 REMARK 500 ARG B 887 -176.77 -67.16 REMARK 500 GLN B 907 44.81 -143.67 REMARK 500 VAL B 929 -60.92 -122.71 REMARK 500 ASP B 940 -178.87 -67.58 REMARK 500 ILE B 985 109.67 -55.47 REMARK 500 PHE B1012 51.42 -93.99 REMARK 500 GLU B1148 -103.99 -83.40 REMARK 500 VAL B1149 161.76 150.42 REMARK 500 ALA B1193 89.65 -157.67 REMARK 500 GLN A 112 26.70 49.84 REMARK 500 ASN C 104 37.39 -96.75 REMARK 500 PHE C 165 -64.20 -96.09 REMARK 500 SER C 224 -4.40 74.00 REMARK 500 ASN C 236 66.55 60.67 REMARK 500 MET C 240 88.08 -152.37 REMARK 500 TYR C 270 -12.15 74.51 REMARK 500 VAL C 271 -56.08 -130.42 REMARK 500 TYR C 351 -7.18 72.22 REMARK 500 GLU C 357 -172.97 -68.27 REMARK 500 REMARK 500 THIS ENTRY HAS 122 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 CYS B 237 THR B 238 -149.99 REMARK 500 TYR B 361 SER B 362 135.79 REMARK 500 GLU B 1148 VAL B 1149 141.17 REMARK 500 CYS C 237 THR C 238 -149.95 REMARK 500 TYR C 361 SER C 362 135.77 REMARK 500 GLU C 1148 VAL C 1149 141.18 REMARK 500 CYS E 237 THR E 238 -149.97 REMARK 500 TYR E 361 SER E 362 135.83 REMARK 500 GLU E 1148 VAL E 1149 141.24 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-35422 RELATED DB: EMDB REMARK 900 MERS-COV SPIKE TRIMER IN COMPLEX WITH NANOBODY VHH-T148 DBREF 8IFN B 1 1333 UNP R9UQ53 R9UQ53_MERS 1 1324 DBREF 8IFN A 1 135 PDB 8IFN 8IFN 1 135 DBREF 8IFN C 1 1333 UNP R9UQ53 R9UQ53_MERS 1 1324 DBREF 8IFN D 1 135 PDB 8IFN 8IFN 1 135 DBREF 8IFN E 1 1333 UNP R9UQ53 R9UQ53_MERS 1 1324 DBREF 8IFN F 1 135 PDB 8IFN 8IFN 1 135 SEQADV 8IFN SER B 748 UNP R9UQ53 ARG 748 CONFLICT SEQADV 8IFN GLY B 751 UNP R9UQ53 ARG 751 CONFLICT SEQADV 8IFN GLN B 1020 UNP R9UQ53 ARG 1020 CONFLICT SEQADV 8IFN PRO B 1060 UNP R9UQ53 VAL 1060 CONFLICT SEQADV 8IFN PRO B 1061 UNP R9UQ53 LEU 1061 CONFLICT SEQADV 8IFN GLN B 1208 UNP R9UQ53 HIS 1208 CONFLICT SEQADV 8IFN SER B 1291 UNP R9UQ53 INSERTION SEQADV 8IFN ARG B 1292 UNP R9UQ53 INSERTION SEQADV 8IFN GLU B 1293 UNP R9UQ53 INSERTION SEQADV 8IFN ASN B 1294 UNP R9UQ53 INSERTION SEQADV 8IFN LEU B 1295 UNP R9UQ53 INSERTION SEQADV 8IFN PHE B 1297 UNP R9UQ53 INSERTION SEQADV 8IFN GLN B 1298 UNP R9UQ53 INSERTION SEQADV 8IFN GLY B 1299 UNP R9UQ53 INSERTION SEQADV 8IFN GLY B 1300 UNP R9UQ53 INSERTION SEQADV 8IFN GLY B 1301 UNP R9UQ53 TYR 1292 CONFLICT SEQADV 8IFN SER B 1302 UNP R9UQ53 ASN 1293 CONFLICT SEQADV 8IFN ALA B 1303 UNP R9UQ53 LYS 1294 CONFLICT SEQADV 8IFN GLY B 1304 UNP R9UQ53 TRP 1295 CONFLICT SEQADV 8IFN SER B 1305 UNP R9UQ53 PRO 1296 CONFLICT SEQADV 8IFN GLY B 1306 UNP R9UQ53 TRP 1297 CONFLICT SEQADV 8IFN PRO B 1309 UNP R9UQ53 TRP 1300 CONFLICT SEQADV 8IFN GLU B 1310 UNP R9UQ53 LEU 1301 CONFLICT SEQADV 8IFN ALA B 1311 UNP R9UQ53 GLY 1302 CONFLICT SEQADV 8IFN PRO B 1312 UNP R9UQ53 PHE 1303 CONFLICT SEQADV 8IFN ARG B 1313 UNP R9UQ53 ILE 1304 CONFLICT SEQADV 8IFN ASP B 1314 UNP R9UQ53 ALA 1305 CONFLICT SEQADV 8IFN GLN B 1316 UNP R9UQ53 LEU 1307 CONFLICT SEQADV 8IFN ALA B 1317 UNP R9UQ53 VAL 1308 CONFLICT SEQADV 8IFN TYR B 1318 UNP R9UQ53 ALA 1309 CONFLICT SEQADV 8IFN VAL B 1319 UNP R9UQ53 LEU 1310 CONFLICT SEQADV 8IFN ARG B 1320 UNP R9UQ53 ALA 1311 CONFLICT SEQADV 8IFN LYS B 1321 UNP R9UQ53 LEU 1312 CONFLICT SEQADV 8IFN ASP B 1322 UNP R9UQ53 CYS 1313 CONFLICT SEQADV 8IFN GLY B 1323 UNP R9UQ53 VAL 1314 CONFLICT SEQADV 8IFN GLU B 1324 UNP R9UQ53 PHE 1315 CONFLICT SEQADV 8IFN TRP B 1325 UNP R9UQ53 PHE 1316 CONFLICT SEQADV 8IFN VAL B 1326 UNP R9UQ53 ILE 1317 CONFLICT SEQADV 8IFN LEU B 1328 UNP R9UQ53 CYS 1319 CONFLICT SEQADV 8IFN SER B 1329 UNP R9UQ53 CYS 1320 CONFLICT SEQADV 8IFN PHE B 1331 UNP R9UQ53 GLY 1322 CONFLICT SEQADV 8IFN LEU B 1332 UNP R9UQ53 CYS 1323 CONFLICT SEQADV 8IFN HIS B 1334 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS B 1335 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS B 1336 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS B 1337 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS B 1338 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS B 1339 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN TRP B 1340 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN SER B 1341 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS B 1342 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN PRO B 1343 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN GLN B 1344 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN PHE B 1345 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN GLU B 1346 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN LYS B 1347 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN SER C 748 UNP R9UQ53 ARG 748 CONFLICT SEQADV 8IFN GLY C 751 UNP R9UQ53 ARG 751 CONFLICT SEQADV 8IFN GLN C 1020 UNP R9UQ53 ARG 1020 CONFLICT SEQADV 8IFN PRO C 1060 UNP R9UQ53 VAL 1060 CONFLICT SEQADV 8IFN PRO C 1061 UNP R9UQ53 LEU 1061 CONFLICT SEQADV 8IFN GLN C 1208 UNP R9UQ53 HIS 1208 CONFLICT SEQADV 8IFN SER C 1291 UNP R9UQ53 INSERTION SEQADV 8IFN ARG C 1292 UNP R9UQ53 INSERTION SEQADV 8IFN GLU C 1293 UNP R9UQ53 INSERTION SEQADV 8IFN ASN C 1294 UNP R9UQ53 INSERTION SEQADV 8IFN LEU C 1295 UNP R9UQ53 INSERTION SEQADV 8IFN PHE C 1297 UNP R9UQ53 INSERTION SEQADV 8IFN GLN C 1298 UNP R9UQ53 INSERTION SEQADV 8IFN GLY C 1299 UNP R9UQ53 INSERTION SEQADV 8IFN GLY C 1300 UNP R9UQ53 INSERTION SEQADV 8IFN GLY C 1301 UNP R9UQ53 TYR 1292 CONFLICT SEQADV 8IFN SER C 1302 UNP R9UQ53 ASN 1293 CONFLICT SEQADV 8IFN ALA C 1303 UNP R9UQ53 LYS 1294 CONFLICT SEQADV 8IFN GLY C 1304 UNP R9UQ53 TRP 1295 CONFLICT SEQADV 8IFN SER C 1305 UNP R9UQ53 PRO 1296 CONFLICT SEQADV 8IFN GLY C 1306 UNP R9UQ53 TRP 1297 CONFLICT SEQADV 8IFN PRO C 1309 UNP R9UQ53 TRP 1300 CONFLICT SEQADV 8IFN GLU C 1310 UNP R9UQ53 LEU 1301 CONFLICT SEQADV 8IFN ALA C 1311 UNP R9UQ53 GLY 1302 CONFLICT SEQADV 8IFN PRO C 1312 UNP R9UQ53 PHE 1303 CONFLICT SEQADV 8IFN ARG C 1313 UNP R9UQ53 ILE 1304 CONFLICT SEQADV 8IFN ASP C 1314 UNP R9UQ53 ALA 1305 CONFLICT SEQADV 8IFN GLN C 1316 UNP R9UQ53 LEU 1307 CONFLICT SEQADV 8IFN ALA C 1317 UNP R9UQ53 VAL 1308 CONFLICT SEQADV 8IFN TYR C 1318 UNP R9UQ53 ALA 1309 CONFLICT SEQADV 8IFN VAL C 1319 UNP R9UQ53 LEU 1310 CONFLICT SEQADV 8IFN ARG C 1320 UNP R9UQ53 ALA 1311 CONFLICT SEQADV 8IFN LYS C 1321 UNP R9UQ53 LEU 1312 CONFLICT SEQADV 8IFN ASP C 1322 UNP R9UQ53 CYS 1313 CONFLICT SEQADV 8IFN GLY C 1323 UNP R9UQ53 VAL 1314 CONFLICT SEQADV 8IFN GLU C 1324 UNP R9UQ53 PHE 1315 CONFLICT SEQADV 8IFN TRP C 1325 UNP R9UQ53 PHE 1316 CONFLICT SEQADV 8IFN VAL C 1326 UNP R9UQ53 ILE 1317 CONFLICT SEQADV 8IFN LEU C 1328 UNP R9UQ53 CYS 1319 CONFLICT SEQADV 8IFN SER C 1329 UNP R9UQ53 CYS 1320 CONFLICT SEQADV 8IFN PHE C 1331 UNP R9UQ53 GLY 1322 CONFLICT SEQADV 8IFN LEU C 1332 UNP R9UQ53 CYS 1323 CONFLICT SEQADV 8IFN HIS C 1334 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS C 1335 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS C 1336 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS C 1337 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS C 1338 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS C 1339 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN TRP C 1340 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN SER C 1341 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS C 1342 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN PRO C 1343 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN GLN C 1344 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN PHE C 1345 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN GLU C 1346 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN LYS C 1347 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN SER E 748 UNP R9UQ53 ARG 748 CONFLICT SEQADV 8IFN GLY E 751 UNP R9UQ53 ARG 751 CONFLICT SEQADV 8IFN GLN E 1020 UNP R9UQ53 ARG 1020 CONFLICT SEQADV 8IFN PRO E 1060 UNP R9UQ53 VAL 1060 CONFLICT SEQADV 8IFN PRO E 1061 UNP R9UQ53 LEU 1061 CONFLICT SEQADV 8IFN GLN E 1208 UNP R9UQ53 HIS 1208 CONFLICT SEQADV 8IFN SER E 1291 UNP R9UQ53 INSERTION SEQADV 8IFN ARG E 1292 UNP R9UQ53 INSERTION SEQADV 8IFN GLU E 1293 UNP R9UQ53 INSERTION SEQADV 8IFN ASN E 1294 UNP R9UQ53 INSERTION SEQADV 8IFN LEU E 1295 UNP R9UQ53 INSERTION SEQADV 8IFN PHE E 1297 UNP R9UQ53 INSERTION SEQADV 8IFN GLN E 1298 UNP R9UQ53 INSERTION SEQADV 8IFN GLY E 1299 UNP R9UQ53 INSERTION SEQADV 8IFN GLY E 1300 UNP R9UQ53 INSERTION SEQADV 8IFN GLY E 1301 UNP R9UQ53 TYR 1292 CONFLICT SEQADV 8IFN SER E 1302 UNP R9UQ53 ASN 1293 CONFLICT SEQADV 8IFN ALA E 1303 UNP R9UQ53 LYS 1294 CONFLICT SEQADV 8IFN GLY E 1304 UNP R9UQ53 TRP 1295 CONFLICT SEQADV 8IFN SER E 1305 UNP R9UQ53 PRO 1296 CONFLICT SEQADV 8IFN GLY E 1306 UNP R9UQ53 TRP 1297 CONFLICT SEQADV 8IFN PRO E 1309 UNP R9UQ53 TRP 1300 CONFLICT SEQADV 8IFN GLU E 1310 UNP R9UQ53 LEU 1301 CONFLICT SEQADV 8IFN ALA E 1311 UNP R9UQ53 GLY 1302 CONFLICT SEQADV 8IFN PRO E 1312 UNP R9UQ53 PHE 1303 CONFLICT SEQADV 8IFN ARG E 1313 UNP R9UQ53 ILE 1304 CONFLICT SEQADV 8IFN ASP E 1314 UNP R9UQ53 ALA 1305 CONFLICT SEQADV 8IFN GLN E 1316 UNP R9UQ53 LEU 1307 CONFLICT SEQADV 8IFN ALA E 1317 UNP R9UQ53 VAL 1308 CONFLICT SEQADV 8IFN TYR E 1318 UNP R9UQ53 ALA 1309 CONFLICT SEQADV 8IFN VAL E 1319 UNP R9UQ53 LEU 1310 CONFLICT SEQADV 8IFN ARG E 1320 UNP R9UQ53 ALA 1311 CONFLICT SEQADV 8IFN LYS E 1321 UNP R9UQ53 LEU 1312 CONFLICT SEQADV 8IFN ASP E 1322 UNP R9UQ53 CYS 1313 CONFLICT SEQADV 8IFN GLY E 1323 UNP R9UQ53 VAL 1314 CONFLICT SEQADV 8IFN GLU E 1324 UNP R9UQ53 PHE 1315 CONFLICT SEQADV 8IFN TRP E 1325 UNP R9UQ53 PHE 1316 CONFLICT SEQADV 8IFN VAL E 1326 UNP R9UQ53 ILE 1317 CONFLICT SEQADV 8IFN LEU E 1328 UNP R9UQ53 CYS 1319 CONFLICT SEQADV 8IFN SER E 1329 UNP R9UQ53 CYS 1320 CONFLICT SEQADV 8IFN PHE E 1331 UNP R9UQ53 GLY 1322 CONFLICT SEQADV 8IFN LEU E 1332 UNP R9UQ53 CYS 1323 CONFLICT SEQADV 8IFN HIS E 1334 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS E 1335 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS E 1336 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS E 1337 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS E 1338 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS E 1339 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN TRP E 1340 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN SER E 1341 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN HIS E 1342 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN PRO E 1343 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN GLN E 1344 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN PHE E 1345 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN GLU E 1346 UNP R9UQ53 EXPRESSION TAG SEQADV 8IFN LYS E 1347 UNP R9UQ53 EXPRESSION TAG SEQRES 1 B 1347 MET ILE HIS SER VAL PHE LEU LEU MET PHE LEU LEU THR SEQRES 2 B 1347 PRO THR GLU SER TYR VAL ASP VAL GLY PRO ASP SER VAL SEQRES 3 B 1347 LYS SER ALA CYS ILE GLU VAL ASP ILE GLN GLN THR PHE SEQRES 4 B 1347 PHE ASP LYS THR TRP PRO ARG PRO ILE ASP VAL SER LYS SEQRES 5 B 1347 ALA ASP GLY ILE ILE TYR PRO GLN GLY ARG THR TYR SER SEQRES 6 B 1347 ASN ILE THR ILE THR TYR GLN GLY LEU PHE PRO TYR GLN SEQRES 7 B 1347 GLY ASP HIS GLY ASP MET TYR VAL TYR SER ALA GLY HIS SEQRES 8 B 1347 ALA THR GLY THR THR PRO GLN LYS LEU PHE VAL ALA ASN SEQRES 9 B 1347 TYR SER GLN ASP VAL LYS GLN PHE ALA ASN GLY PHE VAL SEQRES 10 B 1347 VAL ARG ILE GLY ALA ALA ALA ASN SER THR GLY THR VAL SEQRES 11 B 1347 ILE ILE SER PRO SER THR SER ALA THR ILE ARG LYS ILE SEQRES 12 B 1347 TYR PRO ALA PHE MET LEU GLY SER SER VAL GLY ASN PHE SEQRES 13 B 1347 SER ASP GLY LYS MET GLY ARG PHE PHE ASN HIS THR LEU SEQRES 14 B 1347 VAL LEU LEU PRO ASP GLY CYS GLY THR LEU LEU ARG ALA SEQRES 15 B 1347 PHE TYR CYS ILE LEU GLU PRO ARG SER GLY ASN HIS CYS SEQRES 16 B 1347 PRO ALA GLY ASN SER TYR THR SER PHE ALA THR TYR HIS SEQRES 17 B 1347 THR PRO ALA THR ASP CYS SER ASP GLY ASN TYR ASN ARG SEQRES 18 B 1347 ASN ALA SER LEU ASN SER PHE LYS GLU TYR PHE ASN LEU SEQRES 19 B 1347 ARG ASN CYS THR PHE MET TYR THR TYR ASN ILE THR GLU SEQRES 20 B 1347 ASP GLU ILE LEU GLU TRP PHE GLY ILE THR GLN THR ALA SEQRES 21 B 1347 GLN GLY VAL HIS LEU PHE SER SER ARG TYR VAL ASP LEU SEQRES 22 B 1347 TYR GLY GLY ASN MET PHE GLN PHE ALA THR LEU PRO VAL SEQRES 23 B 1347 TYR ASP THR ILE LYS TYR TYR SER ILE ILE PRO HIS SER SEQRES 24 B 1347 ILE ARG SER ILE GLN SER ASP ARG LYS ALA TRP ALA ALA SEQRES 25 B 1347 PHE TYR VAL TYR LYS LEU GLN PRO LEU THR PHE LEU LEU SEQRES 26 B 1347 ASP PHE SER VAL ASP GLY TYR ILE ARG ARG ALA ILE ASP SEQRES 27 B 1347 CYS GLY PHE ASN ASP LEU SER GLN LEU HIS CYS SER TYR SEQRES 28 B 1347 GLU SER PHE ASP VAL GLU SER GLY VAL TYR SER VAL SER SEQRES 29 B 1347 SER PHE GLU ALA LYS PRO SER GLY SER VAL VAL GLU GLN SEQRES 30 B 1347 ALA GLU GLY VAL GLU CYS ASP PHE SER PRO LEU LEU SER SEQRES 31 B 1347 GLY THR PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL SEQRES 32 B 1347 PHE THR ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER SEQRES 33 B 1347 LEU PHE SER VAL ASN ASP PHE THR CYS SER GLN ILE SER SEQRES 34 B 1347 PRO ALA ALA ILE ALA SER ASN CYS TYR SER SER LEU ILE SEQRES 35 B 1347 LEU ASP TYR PHE SER TYR PRO LEU SER MET LYS SER ASP SEQRES 36 B 1347 LEU SER VAL SER SER ALA GLY PRO ILE SER GLN PHE ASN SEQRES 37 B 1347 TYR LYS GLN SER PHE SER ASN PRO THR CYS LEU ILE LEU SEQRES 38 B 1347 ALA THR VAL PRO HIS ASN LEU THR THR ILE THR LYS PRO SEQRES 39 B 1347 LEU LYS TYR SER TYR ILE ASN LYS CYS SER ARG LEU LEU SEQRES 40 B 1347 SER ASP ASP ARG THR GLU VAL PRO GLN LEU VAL ASN ALA SEQRES 41 B 1347 ASN GLN TYR SER PRO CYS VAL SER ILE VAL PRO SER THR SEQRES 42 B 1347 VAL TRP GLU ASP GLY ASP TYR TYR ARG LYS GLN LEU SER SEQRES 43 B 1347 PRO LEU GLU GLY GLY GLY TRP LEU VAL ALA SER GLY SER SEQRES 44 B 1347 THR VAL ALA MET THR GLU GLN LEU GLN MET GLY PHE GLY SEQRES 45 B 1347 ILE THR VAL GLN TYR GLY THR ASP THR ASN SER VAL CYS SEQRES 46 B 1347 PRO LYS LEU GLU PHE ALA ASN ASP THR LYS ILE ALA SER SEQRES 47 B 1347 GLN LEU GLY ASN CYS VAL GLU TYR SER LEU TYR GLY VAL SEQRES 48 B 1347 SER GLY ARG GLY VAL PHE GLN ASN CYS THR ALA VAL GLY SEQRES 49 B 1347 VAL ARG GLN GLN ARG PHE VAL TYR ASP ALA TYR GLN ASN SEQRES 50 B 1347 LEU VAL GLY TYR TYR SER ASP ASP GLY ASN TYR TYR CYS SEQRES 51 B 1347 LEU ARG ALA CYS VAL SER VAL PRO VAL SER VAL ILE TYR SEQRES 52 B 1347 ASP LYS GLU THR LYS THR HIS ALA THR LEU PHE GLY SER SEQRES 53 B 1347 VAL ALA CYS GLU HIS ILE SER SER THR MET SER GLN TYR SEQRES 54 B 1347 SER ARG SER THR ARG SER MET LEU LYS ARG ARG ASP SER SEQRES 55 B 1347 THR TYR GLY PRO LEU GLN THR PRO VAL GLY CYS VAL LEU SEQRES 56 B 1347 GLY LEU VAL ASN SER SER LEU PHE VAL GLU ASP CYS LYS SEQRES 57 B 1347 LEU PRO LEU GLY GLN SER LEU CYS ALA LEU PRO ASP THR SEQRES 58 B 1347 PRO SER THR LEU THR PRO SER SER VAL GLY SER VAL PRO SEQRES 59 B 1347 GLY GLU MET ARG LEU ALA SER ILE ALA PHE ASN HIS PRO SEQRES 60 B 1347 ILE GLN VAL ASP GLN LEU ASN SER SER TYR PHE LYS LEU SEQRES 61 B 1347 SER ILE PRO THR ASN PHE SER PHE GLY VAL THR GLN GLU SEQRES 62 B 1347 TYR ILE GLN THR THR ILE GLN LYS VAL THR VAL ASP CYS SEQRES 63 B 1347 LYS GLN TYR VAL CYS ASN GLY PHE GLN LYS CYS GLU GLN SEQRES 64 B 1347 LEU LEU ARG GLU TYR GLY GLN PHE CYS SER LYS ILE ASN SEQRES 65 B 1347 GLN ALA LEU HIS GLY ALA ASN LEU ARG GLN ASP ASP SER SEQRES 66 B 1347 VAL ARG ASN LEU PHE ALA SER VAL LYS SER SER GLN SER SEQRES 67 B 1347 SER PRO ILE ILE PRO GLY PHE GLY GLY ASP PHE ASN LEU SEQRES 68 B 1347 THR LEU LEU GLU PRO VAL SER ILE SER THR GLY SER ARG SEQRES 69 B 1347 SER ALA ARG SER ALA ILE GLU ASP LEU LEU PHE ASP LYS SEQRES 70 B 1347 VAL THR ILE ALA ASP PRO GLY TYR MET GLN GLY TYR ASP SEQRES 71 B 1347 ASP CYS MET GLN GLN GLY PRO ALA SER ALA ARG ASP LEU SEQRES 72 B 1347 ILE CYS ALA GLN TYR VAL ALA GLY TYR LYS VAL LEU PRO SEQRES 73 B 1347 PRO LEU MET ASP VAL ASN MET GLU ALA ALA TYR THR SER SEQRES 74 B 1347 SER LEU LEU GLY SER ILE ALA GLY VAL GLY TRP THR ALA SEQRES 75 B 1347 GLY LEU SER SER PHE ALA ALA ILE PRO PHE ALA GLN SER SEQRES 76 B 1347 ILE PHE TYR ARG LEU ASN GLY VAL GLY ILE THR GLN GLN SEQRES 77 B 1347 VAL LEU SER GLU ASN GLN LYS LEU ILE ALA ASN LYS PHE SEQRES 78 B 1347 ASN GLN ALA LEU GLY ALA MET GLN THR GLY PHE THR THR SEQRES 79 B 1347 THR ASN GLU ALA PHE GLN LYS VAL GLN ASP ALA VAL ASN SEQRES 80 B 1347 ASN ASN ALA GLN ALA LEU SER LYS LEU ALA SER GLU LEU SEQRES 81 B 1347 SER ASN THR PHE GLY ALA ILE SER ALA SER ILE GLY ASP SEQRES 82 B 1347 ILE ILE GLN ARG LEU ASP PRO PRO GLU GLN ASP ALA GLN SEQRES 83 B 1347 ILE ASP ARG LEU ILE ASN GLY ARG LEU THR THR LEU ASN SEQRES 84 B 1347 ALA PHE VAL ALA GLN GLN LEU VAL ARG SER GLU SER ALA SEQRES 85 B 1347 ALA LEU SER ALA GLN LEU ALA LYS ASP LYS VAL ASN GLU SEQRES 86 B 1347 CYS VAL LYS ALA GLN SER LYS ARG SER GLY PHE CYS GLY SEQRES 87 B 1347 GLN GLY THR HIS ILE VAL SER PHE VAL VAL ASN ALA PRO SEQRES 88 B 1347 ASN GLY LEU TYR PHE MET HIS VAL GLY TYR TYR PRO SER SEQRES 89 B 1347 ASN HIS ILE GLU VAL VAL SER ALA TYR GLY LEU CYS ASP SEQRES 90 B 1347 ALA ALA ASN PRO THR ASN CYS ILE ALA PRO VAL ASN GLY SEQRES 91 B 1347 TYR PHE ILE LYS THR ASN ASN THR ARG ILE VAL ASP GLU SEQRES 92 B 1347 TRP SER TYR THR GLY SER SER PHE TYR ALA PRO GLU PRO SEQRES 93 B 1347 ILE THR SER LEU ASN THR LYS TYR VAL ALA PRO GLN VAL SEQRES 94 B 1347 THR TYR GLN ASN ILE SER THR ASN LEU PRO PRO PRO LEU SEQRES 95 B 1347 LEU GLY ASN SER THR GLY ILE ASP PHE GLN ASP GLU LEU SEQRES 96 B 1347 ASP GLU PHE PHE LYS ASN VAL SER THR SER ILE PRO ASN SEQRES 97 B 1347 PHE GLY SER LEU THR GLN ILE ASN THR THR LEU LEU ASP SEQRES 98 B 1347 LEU THR TYR GLU MET LEU SER LEU GLN GLN VAL VAL LYS SEQRES 99 B 1347 ALA LEU ASN GLU SER TYR ILE ASP LEU LYS GLU LEU GLY SEQRES 100 B 1347 ASN TYR THR SER ARG GLU ASN LEU TYR PHE GLN GLY GLY SEQRES 101 B 1347 GLY SER ALA GLY SER GLY TYR ILE PRO GLU ALA PRO ARG SEQRES 102 B 1347 ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL SEQRES 103 B 1347 LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 104 B 1347 TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 A 135 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY SER VAL GLN SEQRES 2 A 135 ALA GLY GLY SER LEU LYS LEU SER CYS SER VAL SER GLY SEQRES 3 A 135 TYR THR TYR SER THR TYR CYS ILE ALA TRP PHE ARG GLN SEQRES 4 A 135 VAL PRO GLY LYS GLU ARG GLU GLY LEU ALA PHE ILE LYS SEQRES 5 A 135 ASN PRO GLU GLY ASN THR ASP TYR ALA ASP SER VAL GLN SEQRES 6 A 135 GLY ARG PHE PHE ILE SER GLN ASP THR VAL ASP ASN THR SEQRES 7 A 135 VAL TYR LEU SER MET ASN SER LEU LYS PRO GLU ASP THR SEQRES 8 A 135 ALA THR TYR TYR CYS ALA GLY ALA VAL SER ASN TRP VAL SEQRES 9 A 135 CYS GLY MET SER ILE LYS SER GLN GLY TYR GLY MET ASP SEQRES 10 A 135 TYR TRP GLY LYS GLY THR GLN VAL THR VAL SER SER HIS SEQRES 11 A 135 HIS HIS HIS HIS HIS SEQRES 1 C 1347 MET ILE HIS SER VAL PHE LEU LEU MET PHE LEU LEU THR SEQRES 2 C 1347 PRO THR GLU SER TYR VAL ASP VAL GLY PRO ASP SER VAL SEQRES 3 C 1347 LYS SER ALA CYS ILE GLU VAL ASP ILE GLN GLN THR PHE SEQRES 4 C 1347 PHE ASP LYS THR TRP PRO ARG PRO ILE ASP VAL SER LYS SEQRES 5 C 1347 ALA ASP GLY ILE ILE TYR PRO GLN GLY ARG THR TYR SER SEQRES 6 C 1347 ASN ILE THR ILE THR TYR GLN GLY LEU PHE PRO TYR GLN SEQRES 7 C 1347 GLY ASP HIS GLY ASP MET TYR VAL TYR SER ALA GLY HIS SEQRES 8 C 1347 ALA THR GLY THR THR PRO GLN LYS LEU PHE VAL ALA ASN SEQRES 9 C 1347 TYR SER GLN ASP VAL LYS GLN PHE ALA ASN GLY PHE VAL SEQRES 10 C 1347 VAL ARG ILE GLY ALA ALA ALA ASN SER THR GLY THR VAL SEQRES 11 C 1347 ILE ILE SER PRO SER THR SER ALA THR ILE ARG LYS ILE SEQRES 12 C 1347 TYR PRO ALA PHE MET LEU GLY SER SER VAL GLY ASN PHE SEQRES 13 C 1347 SER ASP GLY LYS MET GLY ARG PHE PHE ASN HIS THR LEU SEQRES 14 C 1347 VAL LEU LEU PRO ASP GLY CYS GLY THR LEU LEU ARG ALA SEQRES 15 C 1347 PHE TYR CYS ILE LEU GLU PRO ARG SER GLY ASN HIS CYS SEQRES 16 C 1347 PRO ALA GLY ASN SER TYR THR SER PHE ALA THR TYR HIS SEQRES 17 C 1347 THR PRO ALA THR ASP CYS SER ASP GLY ASN TYR ASN ARG SEQRES 18 C 1347 ASN ALA SER LEU ASN SER PHE LYS GLU TYR PHE ASN LEU SEQRES 19 C 1347 ARG ASN CYS THR PHE MET TYR THR TYR ASN ILE THR GLU SEQRES 20 C 1347 ASP GLU ILE LEU GLU TRP PHE GLY ILE THR GLN THR ALA SEQRES 21 C 1347 GLN GLY VAL HIS LEU PHE SER SER ARG TYR VAL ASP LEU SEQRES 22 C 1347 TYR GLY GLY ASN MET PHE GLN PHE ALA THR LEU PRO VAL SEQRES 23 C 1347 TYR ASP THR ILE LYS TYR TYR SER ILE ILE PRO HIS SER SEQRES 24 C 1347 ILE ARG SER ILE GLN SER ASP ARG LYS ALA TRP ALA ALA SEQRES 25 C 1347 PHE TYR VAL TYR LYS LEU GLN PRO LEU THR PHE LEU LEU SEQRES 26 C 1347 ASP PHE SER VAL ASP GLY TYR ILE ARG ARG ALA ILE ASP SEQRES 27 C 1347 CYS GLY PHE ASN ASP LEU SER GLN LEU HIS CYS SER TYR SEQRES 28 C 1347 GLU SER PHE ASP VAL GLU SER GLY VAL TYR SER VAL SER SEQRES 29 C 1347 SER PHE GLU ALA LYS PRO SER GLY SER VAL VAL GLU GLN SEQRES 30 C 1347 ALA GLU GLY VAL GLU CYS ASP PHE SER PRO LEU LEU SER SEQRES 31 C 1347 GLY THR PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL SEQRES 32 C 1347 PHE THR ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER SEQRES 33 C 1347 LEU PHE SER VAL ASN ASP PHE THR CYS SER GLN ILE SER SEQRES 34 C 1347 PRO ALA ALA ILE ALA SER ASN CYS TYR SER SER LEU ILE SEQRES 35 C 1347 LEU ASP TYR PHE SER TYR PRO LEU SER MET LYS SER ASP SEQRES 36 C 1347 LEU SER VAL SER SER ALA GLY PRO ILE SER GLN PHE ASN SEQRES 37 C 1347 TYR LYS GLN SER PHE SER ASN PRO THR CYS LEU ILE LEU SEQRES 38 C 1347 ALA THR VAL PRO HIS ASN LEU THR THR ILE THR LYS PRO SEQRES 39 C 1347 LEU LYS TYR SER TYR ILE ASN LYS CYS SER ARG LEU LEU SEQRES 40 C 1347 SER ASP ASP ARG THR GLU VAL PRO GLN LEU VAL ASN ALA SEQRES 41 C 1347 ASN GLN TYR SER PRO CYS VAL SER ILE VAL PRO SER THR SEQRES 42 C 1347 VAL TRP GLU ASP GLY ASP TYR TYR ARG LYS GLN LEU SER SEQRES 43 C 1347 PRO LEU GLU GLY GLY GLY TRP LEU VAL ALA SER GLY SER SEQRES 44 C 1347 THR VAL ALA MET THR GLU GLN LEU GLN MET GLY PHE GLY SEQRES 45 C 1347 ILE THR VAL GLN TYR GLY THR ASP THR ASN SER VAL CYS SEQRES 46 C 1347 PRO LYS LEU GLU PHE ALA ASN ASP THR LYS ILE ALA SER SEQRES 47 C 1347 GLN LEU GLY ASN CYS VAL GLU TYR SER LEU TYR GLY VAL SEQRES 48 C 1347 SER GLY ARG GLY VAL PHE GLN ASN CYS THR ALA VAL GLY SEQRES 49 C 1347 VAL ARG GLN GLN ARG PHE VAL TYR ASP ALA TYR GLN ASN SEQRES 50 C 1347 LEU VAL GLY TYR TYR SER ASP ASP GLY ASN TYR TYR CYS SEQRES 51 C 1347 LEU ARG ALA CYS VAL SER VAL PRO VAL SER VAL ILE TYR SEQRES 52 C 1347 ASP LYS GLU THR LYS THR HIS ALA THR LEU PHE GLY SER SEQRES 53 C 1347 VAL ALA CYS GLU HIS ILE SER SER THR MET SER GLN TYR SEQRES 54 C 1347 SER ARG SER THR ARG SER MET LEU LYS ARG ARG ASP SER SEQRES 55 C 1347 THR TYR GLY PRO LEU GLN THR PRO VAL GLY CYS VAL LEU SEQRES 56 C 1347 GLY LEU VAL ASN SER SER LEU PHE VAL GLU ASP CYS LYS SEQRES 57 C 1347 LEU PRO LEU GLY GLN SER LEU CYS ALA LEU PRO ASP THR SEQRES 58 C 1347 PRO SER THR LEU THR PRO SER SER VAL GLY SER VAL PRO SEQRES 59 C 1347 GLY GLU MET ARG LEU ALA SER ILE ALA PHE ASN HIS PRO SEQRES 60 C 1347 ILE GLN VAL ASP GLN LEU ASN SER SER TYR PHE LYS LEU SEQRES 61 C 1347 SER ILE PRO THR ASN PHE SER PHE GLY VAL THR GLN GLU SEQRES 62 C 1347 TYR ILE GLN THR THR ILE GLN LYS VAL THR VAL ASP CYS SEQRES 63 C 1347 LYS GLN TYR VAL CYS ASN GLY PHE GLN LYS CYS GLU GLN SEQRES 64 C 1347 LEU LEU ARG GLU TYR GLY GLN PHE CYS SER LYS ILE ASN SEQRES 65 C 1347 GLN ALA LEU HIS GLY ALA ASN LEU ARG GLN ASP ASP SER SEQRES 66 C 1347 VAL ARG ASN LEU PHE ALA SER VAL LYS SER SER GLN SER SEQRES 67 C 1347 SER PRO ILE ILE PRO GLY PHE GLY GLY ASP PHE ASN LEU SEQRES 68 C 1347 THR LEU LEU GLU PRO VAL SER ILE SER THR GLY SER ARG SEQRES 69 C 1347 SER ALA ARG SER ALA ILE GLU ASP LEU LEU PHE ASP LYS SEQRES 70 C 1347 VAL THR ILE ALA ASP PRO GLY TYR MET GLN GLY TYR ASP SEQRES 71 C 1347 ASP CYS MET GLN GLN GLY PRO ALA SER ALA ARG ASP LEU SEQRES 72 C 1347 ILE CYS ALA GLN TYR VAL ALA GLY TYR LYS VAL LEU PRO SEQRES 73 C 1347 PRO LEU MET ASP VAL ASN MET GLU ALA ALA TYR THR SER SEQRES 74 C 1347 SER LEU LEU GLY SER ILE ALA GLY VAL GLY TRP THR ALA SEQRES 75 C 1347 GLY LEU SER SER PHE ALA ALA ILE PRO PHE ALA GLN SER SEQRES 76 C 1347 ILE PHE TYR ARG LEU ASN GLY VAL GLY ILE THR GLN GLN SEQRES 77 C 1347 VAL LEU SER GLU ASN GLN LYS LEU ILE ALA ASN LYS PHE SEQRES 78 C 1347 ASN GLN ALA LEU GLY ALA MET GLN THR GLY PHE THR THR SEQRES 79 C 1347 THR ASN GLU ALA PHE GLN LYS VAL GLN ASP ALA VAL ASN SEQRES 80 C 1347 ASN ASN ALA GLN ALA LEU SER LYS LEU ALA SER GLU LEU SEQRES 81 C 1347 SER ASN THR PHE GLY ALA ILE SER ALA SER ILE GLY ASP SEQRES 82 C 1347 ILE ILE GLN ARG LEU ASP PRO PRO GLU GLN ASP ALA GLN SEQRES 83 C 1347 ILE ASP ARG LEU ILE ASN GLY ARG LEU THR THR LEU ASN SEQRES 84 C 1347 ALA PHE VAL ALA GLN GLN LEU VAL ARG SER GLU SER ALA SEQRES 85 C 1347 ALA LEU SER ALA GLN LEU ALA LYS ASP LYS VAL ASN GLU SEQRES 86 C 1347 CYS VAL LYS ALA GLN SER LYS ARG SER GLY PHE CYS GLY SEQRES 87 C 1347 GLN GLY THR HIS ILE VAL SER PHE VAL VAL ASN ALA PRO SEQRES 88 C 1347 ASN GLY LEU TYR PHE MET HIS VAL GLY TYR TYR PRO SER SEQRES 89 C 1347 ASN HIS ILE GLU VAL VAL SER ALA TYR GLY LEU CYS ASP SEQRES 90 C 1347 ALA ALA ASN PRO THR ASN CYS ILE ALA PRO VAL ASN GLY SEQRES 91 C 1347 TYR PHE ILE LYS THR ASN ASN THR ARG ILE VAL ASP GLU SEQRES 92 C 1347 TRP SER TYR THR GLY SER SER PHE TYR ALA PRO GLU PRO SEQRES 93 C 1347 ILE THR SER LEU ASN THR LYS TYR VAL ALA PRO GLN VAL SEQRES 94 C 1347 THR TYR GLN ASN ILE SER THR ASN LEU PRO PRO PRO LEU SEQRES 95 C 1347 LEU GLY ASN SER THR GLY ILE ASP PHE GLN ASP GLU LEU SEQRES 96 C 1347 ASP GLU PHE PHE LYS ASN VAL SER THR SER ILE PRO ASN SEQRES 97 C 1347 PHE GLY SER LEU THR GLN ILE ASN THR THR LEU LEU ASP SEQRES 98 C 1347 LEU THR TYR GLU MET LEU SER LEU GLN GLN VAL VAL LYS SEQRES 99 C 1347 ALA LEU ASN GLU SER TYR ILE ASP LEU LYS GLU LEU GLY SEQRES 100 C 1347 ASN TYR THR SER ARG GLU ASN LEU TYR PHE GLN GLY GLY SEQRES 101 C 1347 GLY SER ALA GLY SER GLY TYR ILE PRO GLU ALA PRO ARG SEQRES 102 C 1347 ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL SEQRES 103 C 1347 LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 104 C 1347 TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 D 135 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY SER VAL GLN SEQRES 2 D 135 ALA GLY GLY SER LEU LYS LEU SER CYS SER VAL SER GLY SEQRES 3 D 135 TYR THR TYR SER THR TYR CYS ILE ALA TRP PHE ARG GLN SEQRES 4 D 135 VAL PRO GLY LYS GLU ARG GLU GLY LEU ALA PHE ILE LYS SEQRES 5 D 135 ASN PRO GLU GLY ASN THR ASP TYR ALA ASP SER VAL GLN SEQRES 6 D 135 GLY ARG PHE PHE ILE SER GLN ASP THR VAL ASP ASN THR SEQRES 7 D 135 VAL TYR LEU SER MET ASN SER LEU LYS PRO GLU ASP THR SEQRES 8 D 135 ALA THR TYR TYR CYS ALA GLY ALA VAL SER ASN TRP VAL SEQRES 9 D 135 CYS GLY MET SER ILE LYS SER GLN GLY TYR GLY MET ASP SEQRES 10 D 135 TYR TRP GLY LYS GLY THR GLN VAL THR VAL SER SER HIS SEQRES 11 D 135 HIS HIS HIS HIS HIS SEQRES 1 E 1347 MET ILE HIS SER VAL PHE LEU LEU MET PHE LEU LEU THR SEQRES 2 E 1347 PRO THR GLU SER TYR VAL ASP VAL GLY PRO ASP SER VAL SEQRES 3 E 1347 LYS SER ALA CYS ILE GLU VAL ASP ILE GLN GLN THR PHE SEQRES 4 E 1347 PHE ASP LYS THR TRP PRO ARG PRO ILE ASP VAL SER LYS SEQRES 5 E 1347 ALA ASP GLY ILE ILE TYR PRO GLN GLY ARG THR TYR SER SEQRES 6 E 1347 ASN ILE THR ILE THR TYR GLN GLY LEU PHE PRO TYR GLN SEQRES 7 E 1347 GLY ASP HIS GLY ASP MET TYR VAL TYR SER ALA GLY HIS SEQRES 8 E 1347 ALA THR GLY THR THR PRO GLN LYS LEU PHE VAL ALA ASN SEQRES 9 E 1347 TYR SER GLN ASP VAL LYS GLN PHE ALA ASN GLY PHE VAL SEQRES 10 E 1347 VAL ARG ILE GLY ALA ALA ALA ASN SER THR GLY THR VAL SEQRES 11 E 1347 ILE ILE SER PRO SER THR SER ALA THR ILE ARG LYS ILE SEQRES 12 E 1347 TYR PRO ALA PHE MET LEU GLY SER SER VAL GLY ASN PHE SEQRES 13 E 1347 SER ASP GLY LYS MET GLY ARG PHE PHE ASN HIS THR LEU SEQRES 14 E 1347 VAL LEU LEU PRO ASP GLY CYS GLY THR LEU LEU ARG ALA SEQRES 15 E 1347 PHE TYR CYS ILE LEU GLU PRO ARG SER GLY ASN HIS CYS SEQRES 16 E 1347 PRO ALA GLY ASN SER TYR THR SER PHE ALA THR TYR HIS SEQRES 17 E 1347 THR PRO ALA THR ASP CYS SER ASP GLY ASN TYR ASN ARG SEQRES 18 E 1347 ASN ALA SER LEU ASN SER PHE LYS GLU TYR PHE ASN LEU SEQRES 19 E 1347 ARG ASN CYS THR PHE MET TYR THR TYR ASN ILE THR GLU SEQRES 20 E 1347 ASP GLU ILE LEU GLU TRP PHE GLY ILE THR GLN THR ALA SEQRES 21 E 1347 GLN GLY VAL HIS LEU PHE SER SER ARG TYR VAL ASP LEU SEQRES 22 E 1347 TYR GLY GLY ASN MET PHE GLN PHE ALA THR LEU PRO VAL SEQRES 23 E 1347 TYR ASP THR ILE LYS TYR TYR SER ILE ILE PRO HIS SER SEQRES 24 E 1347 ILE ARG SER ILE GLN SER ASP ARG LYS ALA TRP ALA ALA SEQRES 25 E 1347 PHE TYR VAL TYR LYS LEU GLN PRO LEU THR PHE LEU LEU SEQRES 26 E 1347 ASP PHE SER VAL ASP GLY TYR ILE ARG ARG ALA ILE ASP SEQRES 27 E 1347 CYS GLY PHE ASN ASP LEU SER GLN LEU HIS CYS SER TYR SEQRES 28 E 1347 GLU SER PHE ASP VAL GLU SER GLY VAL TYR SER VAL SER SEQRES 29 E 1347 SER PHE GLU ALA LYS PRO SER GLY SER VAL VAL GLU GLN SEQRES 30 E 1347 ALA GLU GLY VAL GLU CYS ASP PHE SER PRO LEU LEU SER SEQRES 31 E 1347 GLY THR PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL SEQRES 32 E 1347 PHE THR ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER SEQRES 33 E 1347 LEU PHE SER VAL ASN ASP PHE THR CYS SER GLN ILE SER SEQRES 34 E 1347 PRO ALA ALA ILE ALA SER ASN CYS TYR SER SER LEU ILE SEQRES 35 E 1347 LEU ASP TYR PHE SER TYR PRO LEU SER MET LYS SER ASP SEQRES 36 E 1347 LEU SER VAL SER SER ALA GLY PRO ILE SER GLN PHE ASN SEQRES 37 E 1347 TYR LYS GLN SER PHE SER ASN PRO THR CYS LEU ILE LEU SEQRES 38 E 1347 ALA THR VAL PRO HIS ASN LEU THR THR ILE THR LYS PRO SEQRES 39 E 1347 LEU LYS TYR SER TYR ILE ASN LYS CYS SER ARG LEU LEU SEQRES 40 E 1347 SER ASP ASP ARG THR GLU VAL PRO GLN LEU VAL ASN ALA SEQRES 41 E 1347 ASN GLN TYR SER PRO CYS VAL SER ILE VAL PRO SER THR SEQRES 42 E 1347 VAL TRP GLU ASP GLY ASP TYR TYR ARG LYS GLN LEU SER SEQRES 43 E 1347 PRO LEU GLU GLY GLY GLY TRP LEU VAL ALA SER GLY SER SEQRES 44 E 1347 THR VAL ALA MET THR GLU GLN LEU GLN MET GLY PHE GLY SEQRES 45 E 1347 ILE THR VAL GLN TYR GLY THR ASP THR ASN SER VAL CYS SEQRES 46 E 1347 PRO LYS LEU GLU PHE ALA ASN ASP THR LYS ILE ALA SER SEQRES 47 E 1347 GLN LEU GLY ASN CYS VAL GLU TYR SER LEU TYR GLY VAL SEQRES 48 E 1347 SER GLY ARG GLY VAL PHE GLN ASN CYS THR ALA VAL GLY SEQRES 49 E 1347 VAL ARG GLN GLN ARG PHE VAL TYR ASP ALA TYR GLN ASN SEQRES 50 E 1347 LEU VAL GLY TYR TYR SER ASP ASP GLY ASN TYR TYR CYS SEQRES 51 E 1347 LEU ARG ALA CYS VAL SER VAL PRO VAL SER VAL ILE TYR SEQRES 52 E 1347 ASP LYS GLU THR LYS THR HIS ALA THR LEU PHE GLY SER SEQRES 53 E 1347 VAL ALA CYS GLU HIS ILE SER SER THR MET SER GLN TYR SEQRES 54 E 1347 SER ARG SER THR ARG SER MET LEU LYS ARG ARG ASP SER SEQRES 55 E 1347 THR TYR GLY PRO LEU GLN THR PRO VAL GLY CYS VAL LEU SEQRES 56 E 1347 GLY LEU VAL ASN SER SER LEU PHE VAL GLU ASP CYS LYS SEQRES 57 E 1347 LEU PRO LEU GLY GLN SER LEU CYS ALA LEU PRO ASP THR SEQRES 58 E 1347 PRO SER THR LEU THR PRO SER SER VAL GLY SER VAL PRO SEQRES 59 E 1347 GLY GLU MET ARG LEU ALA SER ILE ALA PHE ASN HIS PRO SEQRES 60 E 1347 ILE GLN VAL ASP GLN LEU ASN SER SER TYR PHE LYS LEU SEQRES 61 E 1347 SER ILE PRO THR ASN PHE SER PHE GLY VAL THR GLN GLU SEQRES 62 E 1347 TYR ILE GLN THR THR ILE GLN LYS VAL THR VAL ASP CYS SEQRES 63 E 1347 LYS GLN TYR VAL CYS ASN GLY PHE GLN LYS CYS GLU GLN SEQRES 64 E 1347 LEU LEU ARG GLU TYR GLY GLN PHE CYS SER LYS ILE ASN SEQRES 65 E 1347 GLN ALA LEU HIS GLY ALA ASN LEU ARG GLN ASP ASP SER SEQRES 66 E 1347 VAL ARG ASN LEU PHE ALA SER VAL LYS SER SER GLN SER SEQRES 67 E 1347 SER PRO ILE ILE PRO GLY PHE GLY GLY ASP PHE ASN LEU SEQRES 68 E 1347 THR LEU LEU GLU PRO VAL SER ILE SER THR GLY SER ARG SEQRES 69 E 1347 SER ALA ARG SER ALA ILE GLU ASP LEU LEU PHE ASP LYS SEQRES 70 E 1347 VAL THR ILE ALA ASP PRO GLY TYR MET GLN GLY TYR ASP SEQRES 71 E 1347 ASP CYS MET GLN GLN GLY PRO ALA SER ALA ARG ASP LEU SEQRES 72 E 1347 ILE CYS ALA GLN TYR VAL ALA GLY TYR LYS VAL LEU PRO SEQRES 73 E 1347 PRO LEU MET ASP VAL ASN MET GLU ALA ALA TYR THR SER SEQRES 74 E 1347 SER LEU LEU GLY SER ILE ALA GLY VAL GLY TRP THR ALA SEQRES 75 E 1347 GLY LEU SER SER PHE ALA ALA ILE PRO PHE ALA GLN SER SEQRES 76 E 1347 ILE PHE TYR ARG LEU ASN GLY VAL GLY ILE THR GLN GLN SEQRES 77 E 1347 VAL LEU SER GLU ASN GLN LYS LEU ILE ALA ASN LYS PHE SEQRES 78 E 1347 ASN GLN ALA LEU GLY ALA MET GLN THR GLY PHE THR THR SEQRES 79 E 1347 THR ASN GLU ALA PHE GLN LYS VAL GLN ASP ALA VAL ASN SEQRES 80 E 1347 ASN ASN ALA GLN ALA LEU SER LYS LEU ALA SER GLU LEU SEQRES 81 E 1347 SER ASN THR PHE GLY ALA ILE SER ALA SER ILE GLY ASP SEQRES 82 E 1347 ILE ILE GLN ARG LEU ASP PRO PRO GLU GLN ASP ALA GLN SEQRES 83 E 1347 ILE ASP ARG LEU ILE ASN GLY ARG LEU THR THR LEU ASN SEQRES 84 E 1347 ALA PHE VAL ALA GLN GLN LEU VAL ARG SER GLU SER ALA SEQRES 85 E 1347 ALA LEU SER ALA GLN LEU ALA LYS ASP LYS VAL ASN GLU SEQRES 86 E 1347 CYS VAL LYS ALA GLN SER LYS ARG SER GLY PHE CYS GLY SEQRES 87 E 1347 GLN GLY THR HIS ILE VAL SER PHE VAL VAL ASN ALA PRO SEQRES 88 E 1347 ASN GLY LEU TYR PHE MET HIS VAL GLY TYR TYR PRO SER SEQRES 89 E 1347 ASN HIS ILE GLU VAL VAL SER ALA TYR GLY LEU CYS ASP SEQRES 90 E 1347 ALA ALA ASN PRO THR ASN CYS ILE ALA PRO VAL ASN GLY SEQRES 91 E 1347 TYR PHE ILE LYS THR ASN ASN THR ARG ILE VAL ASP GLU SEQRES 92 E 1347 TRP SER TYR THR GLY SER SER PHE TYR ALA PRO GLU PRO SEQRES 93 E 1347 ILE THR SER LEU ASN THR LYS TYR VAL ALA PRO GLN VAL SEQRES 94 E 1347 THR TYR GLN ASN ILE SER THR ASN LEU PRO PRO PRO LEU SEQRES 95 E 1347 LEU GLY ASN SER THR GLY ILE ASP PHE GLN ASP GLU LEU SEQRES 96 E 1347 ASP GLU PHE PHE LYS ASN VAL SER THR SER ILE PRO ASN SEQRES 97 E 1347 PHE GLY SER LEU THR GLN ILE ASN THR THR LEU LEU ASP SEQRES 98 E 1347 LEU THR TYR GLU MET LEU SER LEU GLN GLN VAL VAL LYS SEQRES 99 E 1347 ALA LEU ASN GLU SER TYR ILE ASP LEU LYS GLU LEU GLY SEQRES 100 E 1347 ASN TYR THR SER ARG GLU ASN LEU TYR PHE GLN GLY GLY SEQRES 101 E 1347 GLY SER ALA GLY SER GLY TYR ILE PRO GLU ALA PRO ARG SEQRES 102 E 1347 ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL SEQRES 103 E 1347 LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 104 E 1347 TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 F 135 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY SER VAL GLN SEQRES 2 F 135 ALA GLY GLY SER LEU LYS LEU SER CYS SER VAL SER GLY SEQRES 3 F 135 TYR THR TYR SER THR TYR CYS ILE ALA TRP PHE ARG GLN SEQRES 4 F 135 VAL PRO GLY LYS GLU ARG GLU GLY LEU ALA PHE ILE LYS SEQRES 5 F 135 ASN PRO GLU GLY ASN THR ASP TYR ALA ASP SER VAL GLN SEQRES 6 F 135 GLY ARG PHE PHE ILE SER GLN ASP THR VAL ASP ASN THR SEQRES 7 F 135 VAL TYR LEU SER MET ASN SER LEU LYS PRO GLU ASP THR SEQRES 8 F 135 ALA THR TYR TYR CYS ALA GLY ALA VAL SER ASN TRP VAL SEQRES 9 F 135 CYS GLY MET SER ILE LYS SER GLN GLY TYR GLY MET ASP SEQRES 10 F 135 TYR TRP GLY LYS GLY THR GLN VAL THR VAL SER SER HIS SEQRES 11 F 135 HIS HIS HIS HIS HIS HET NAG G 1 14 HET NAG G 2 14 HET BMA G 3 11 HET MAN G 4 11 HET NAG H 1 14 HET NAG H 2 14 HET BMA H 3 11 HET MAN H 4 11 HET NAG I 1 14 HET NAG I 2 14 HET BMA I 3 11 HET MAN I 4 11 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 7 NAG 6(C8 H15 N O6) FORMUL 7 BMA 3(C6 H12 O6) FORMUL 7 MAN 3(C6 H12 O6) HELIX 1 AA1 GLN B 37 ASP B 41 5 5 HELIX 2 AA2 ASP B 49 ALA B 53 5 5 HELIX 3 AA3 THR B 209 ASP B 213 1 5 HELIX 4 AA4 LEU B 225 TYR B 231 1 7 HELIX 5 AA5 ILE B 303 ARG B 307 5 5 HELIX 6 AA6 ASN B 342 SER B 350 1 9 HELIX 7 AA7 TYR B 351 SER B 353 5 3 HELIX 8 AA8 PHE B 385 LEU B 389 5 5 HELIX 9 AA9 GLN B 395 PHE B 399 5 5 HELIX 10 AB1 ASN B 410 LEU B 417 1 8 HELIX 11 AB2 PRO B 449 LEU B 456 5 8 HELIX 12 AB3 PRO B 463 ASN B 468 1 6 HELIX 13 AB4 SER B 524 ILE B 529 5 6 HELIX 14 AB5 SER B 546 GLY B 550 5 5 HELIX 15 AB6 ALA B 678 ILE B 682 5 5 HELIX 16 AB7 ASP B 805 CYS B 811 1 7 HELIX 17 AB8 PHE B 814 ARG B 822 1 9 HELIX 18 AB9 TYR B 824 PHE B 850 1 27 HELIX 19 AC1 SER B 888 VAL B 898 1 11 HELIX 20 AC2 ASP B 910 GLN B 915 1 6 HELIX 21 AC3 ASP B 922 GLN B 927 1 6 HELIX 22 AC4 ASP B 940 GLY B 953 1 14 HELIX 23 AC5 SER B 954 GLY B 959 1 6 HELIX 24 AC6 PRO B 971 GLY B 982 1 12 HELIX 25 AC7 GLN B 987 GLU B 992 1 6 HELIX 26 AC8 LYS B 995 GLN B 1009 1 15 HELIX 27 AC9 ASN B 1016 GLU B 1039 1 24 HELIX 28 AD1 LEU B 1040 ASN B 1042 5 3 HELIX 29 AD2 SER B 1050 LEU B 1058 1 9 HELIX 30 AD3 ASP B 1059 VAL B 1107 1 49 HELIX 31 AD4 PRO B 1219 LEU B 1223 5 5 HELIX 32 AD5 LYS A 87 THR A 91 5 5 HELIX 33 AD6 VAL A 104 LYS A 110 1 7 HELIX 34 AD7 GLN C 37 ASP C 41 5 5 HELIX 35 AD8 ASP C 49 ALA C 53 5 5 HELIX 36 AD9 THR C 209 ASP C 213 1 5 HELIX 37 AE1 LEU C 225 TYR C 231 1 7 HELIX 38 AE2 ASN C 342 SER C 350 1 9 HELIX 39 AE3 TYR C 351 SER C 353 5 3 HELIX 40 AE4 PHE C 385 LEU C 389 5 5 HELIX 41 AE5 GLN C 395 PHE C 399 5 5 HELIX 42 AE6 ASN C 410 LEU C 417 1 8 HELIX 43 AE7 PRO C 449 LEU C 456 5 8 HELIX 44 AE8 PRO C 463 ASN C 468 1 6 HELIX 45 AE9 SER C 524 ILE C 529 5 6 HELIX 46 AF1 SER C 546 GLY C 550 5 5 HELIX 47 AF2 ALA C 678 ILE C 682 5 5 HELIX 48 AF3 ASP C 805 CYS C 811 1 7 HELIX 49 AF4 PHE C 814 ARG C 822 1 9 HELIX 50 AF5 TYR C 824 PHE C 850 1 27 HELIX 51 AF6 SER C 888 VAL C 898 1 11 HELIX 52 AF7 ASP C 910 GLN C 915 1 6 HELIX 53 AF8 ASP C 922 GLN C 927 1 6 HELIX 54 AF9 ASP C 940 GLY C 953 1 14 HELIX 55 AG1 SER C 954 GLY C 959 1 6 HELIX 56 AG2 PRO C 971 GLY C 982 1 12 HELIX 57 AG3 GLN C 987 GLU C 992 1 6 HELIX 58 AG4 LYS C 995 GLN C 1009 1 15 HELIX 59 AG5 ASN C 1016 GLU C 1039 1 24 HELIX 60 AG6 LEU C 1040 ASN C 1042 5 3 HELIX 61 AG7 SER C 1050 LEU C 1058 1 9 HELIX 62 AG8 ASP C 1059 VAL C 1107 1 49 HELIX 63 AG9 PRO C 1219 LEU C 1223 5 5 HELIX 64 AH1 LYS D 87 THR D 91 5 5 HELIX 65 AH2 VAL D 104 LYS D 110 1 7 HELIX 66 AH3 GLN E 37 ASP E 41 5 5 HELIX 67 AH4 ASP E 49 ALA E 53 5 5 HELIX 68 AH5 THR E 209 ASP E 213 1 5 HELIX 69 AH6 LEU E 225 TYR E 231 1 7 HELIX 70 AH7 ASN E 342 SER E 350 1 9 HELIX 71 AH8 TYR E 351 SER E 353 5 3 HELIX 72 AH9 PHE E 385 LEU E 389 5 5 HELIX 73 AI1 GLN E 395 PHE E 399 5 5 HELIX 74 AI2 ASN E 410 LEU E 417 1 8 HELIX 75 AI3 PRO E 449 LEU E 456 5 8 HELIX 76 AI4 PRO E 463 ASN E 468 1 6 HELIX 77 AI5 SER E 524 ILE E 529 5 6 HELIX 78 AI6 SER E 546 GLY E 550 5 5 HELIX 79 AI7 ALA E 678 ILE E 682 5 5 HELIX 80 AI8 ASP E 805 CYS E 811 1 7 HELIX 81 AI9 PHE E 814 ARG E 822 1 9 HELIX 82 AJ1 TYR E 824 PHE E 850 1 27 HELIX 83 AJ2 SER E 888 VAL E 898 1 11 HELIX 84 AJ3 ASP E 910 GLN E 915 1 6 HELIX 85 AJ4 ASP E 922 GLN E 927 1 6 HELIX 86 AJ5 ASP E 940 GLY E 953 1 14 HELIX 87 AJ6 SER E 954 GLY E 959 1 6 HELIX 88 AJ7 PRO E 971 GLY E 982 1 12 HELIX 89 AJ8 GLN E 987 GLU E 992 1 6 HELIX 90 AJ9 LYS E 995 GLN E 1009 1 15 HELIX 91 AK1 ASN E 1016 GLU E 1039 1 24 HELIX 92 AK2 LEU E 1040 ASN E 1042 5 3 HELIX 93 AK3 SER E 1050 LEU E 1058 1 9 HELIX 94 AK4 ASP E 1059 VAL E 1107 1 49 HELIX 95 AK5 PRO E 1219 LEU E 1223 5 5 HELIX 96 AK6 LYS F 87 THR F 91 5 5 HELIX 97 AK7 VAL F 104 LYS F 110 1 7 SHEET 1 AA1 3 VAL B 33 ILE B 35 0 SHEET 2 AA1 3 PRO B 97 VAL B 102 1 O VAL B 102 N ASP B 34 SHEET 3 AA1 3 HIS B 91 ALA B 92 -1 N HIS B 91 O LYS B 99 SHEET 1 AA2 3 ILE B 67 PHE B 75 0 SHEET 2 AA2 3 GLN B 319 PHE B 327 -1 O LEU B 325 N ILE B 69 SHEET 3 AA2 3 ILE B 333 ASP B 338 -1 O ILE B 337 N LEU B 324 SHEET 1 AA3 6 ASP B 83 TYR B 85 0 SHEET 2 AA3 6 PHE B 313 LYS B 317 -1 O PHE B 313 N TYR B 85 SHEET 3 AA3 6 PHE B 116 ILE B 120 -1 N VAL B 117 O TYR B 316 SHEET 4 AA3 6 GLU B 252 THR B 259 -1 O GLU B 252 N ILE B 120 SHEET 5 AA3 6 GLY B 262 SER B 267 -1 O GLY B 262 N THR B 259 SHEET 6 AA3 6 PHE B 279 LEU B 284 -1 O PHE B 281 N LEU B 265 SHEET 1 AA4 3 SER B 88 ALA B 89 0 SHEET 2 AA4 3 HIS B 298 ILE B 300 1 O ILE B 300 N SER B 88 SHEET 3 AA4 3 THR B 206 HIS B 208 1 N THR B 206 O SER B 299 SHEET 1 AA5 6 LYS B 110 GLN B 111 0 SHEET 2 AA5 6 TYR B 292 ILE B 295 -1 O TYR B 293 N LYS B 110 SHEET 3 AA5 6 PHE B 147 GLY B 150 -1 N GLY B 150 O TYR B 292 SHEET 4 AA5 6 THR B 168 ASP B 174 -1 O LEU B 169 N LEU B 149 SHEET 5 AA5 6 LEU B 179 PRO B 189 -1 O ARG B 181 N LEU B 172 SHEET 6 AA5 6 PHE B 232 ARG B 235 -1 O ASN B 233 N GLU B 188 SHEET 1 AA6 6 LYS B 110 GLN B 111 0 SHEET 2 AA6 6 TYR B 292 ILE B 295 -1 O TYR B 293 N LYS B 110 SHEET 3 AA6 6 PHE B 147 GLY B 150 -1 N GLY B 150 O TYR B 292 SHEET 4 AA6 6 THR B 168 ASP B 174 -1 O LEU B 169 N LEU B 149 SHEET 5 AA6 6 LEU B 179 PRO B 189 -1 O ARG B 181 N LEU B 172 SHEET 6 AA6 6 MET B 240 ASN B 244 -1 O TYR B 241 N ALA B 182 SHEET 1 AA7 3 THR B 127 THR B 129 0 SHEET 2 AA7 3 SER B 137 ARG B 141 -1 O ALA B 138 N GLY B 128 SHEET 3 AA7 3 ALA B 309 TRP B 310 1 O ALA B 309 N ARG B 141 SHEET 1 AA8 2 VAL B 153 ASN B 155 0 SHEET 2 AA8 2 MET B 161 PHE B 164 -1 O ARG B 163 N GLY B 154 SHEET 1 AA9 2 CYS B 214 SER B 215 0 SHEET 2 AA9 2 ASN B 218 TYR B 219 -1 O ASN B 218 N SER B 215 SHEET 1 AB1 6 TYR B 689 SER B 690 0 SHEET 2 AB1 6 SER B 362 ALA B 368 -1 N GLU B 367 O SER B 690 SHEET 3 AB1 6 SER B 656 ASP B 664 -1 O VAL B 657 N PHE B 366 SHEET 4 AB1 6 THR B 669 PHE B 674 -1 O ALA B 671 N ILE B 662 SHEET 5 AB1 6 GLY B 712 LEU B 715 -1 O CYS B 713 N PHE B 674 SHEET 6 AB1 6 LEU B 707 THR B 709 -1 N LEU B 707 O VAL B 714 SHEET 1 AB2 3 SER B 373 VAL B 375 0 SHEET 2 AB2 3 VAL B 604 SER B 607 1 O GLU B 605 N VAL B 374 SHEET 3 AB2 3 GLY B 613 GLY B 615 -1 O GLY B 613 N TYR B 606 SHEET 1 AB3 5 LYS B 400 PHE B 404 0 SHEET 2 AB3 5 SER B 440 SER B 447 -1 O LEU B 441 N PHE B 404 SHEET 3 AB3 5 GLN B 568 GLN B 576 -1 O THR B 574 N ILE B 442 SHEET 4 AB3 5 THR B 477 THR B 483 -1 N ILE B 480 O PHE B 571 SHEET 5 AB3 5 SER B 419 SER B 426 -1 N ASN B 421 O LEU B 481 SHEET 1 AB4 2 ASN B 408 TYR B 409 0 SHEET 2 AB4 2 CYS B 585 PRO B 586 1 O CYS B 585 N TYR B 409 SHEET 1 AB5 4 GLU B 513 PRO B 515 0 SHEET 2 AB5 4 TYR B 497 LEU B 506 -1 N ARG B 505 O VAL B 514 SHEET 3 AB5 4 TRP B 553 VAL B 561 -1 O TRP B 553 N LEU B 506 SHEET 4 AB5 4 ASP B 539 GLN B 544 -1 N LYS B 543 O LEU B 554 SHEET 1 AB6 3 PHE B 630 TYR B 632 0 SHEET 2 AB6 3 LEU B 638 TYR B 642 -1 O VAL B 639 N VAL B 631 SHEET 3 AB6 3 TYR B 648 TYR B 649 -1 O TYR B 649 N TYR B 641 SHEET 1 AB7 4 LEU B 717 VAL B 724 0 SHEET 2 AB7 4 MET B 757 ILE B 762 1 O LEU B 759 N VAL B 718 SHEET 3 AB7 4 LEU B 735 LEU B 738 -1 N LEU B 738 O ARG B 758 SHEET 4 AB7 4 PRO B 730 GLY B 732 -1 N LEU B 731 O LEU B 735 SHEET 1 AB8 2 ILE B 768 GLN B 769 0 SHEET 2 AB8 2 GLN C 857 SER C 858 1 O SER C 858 N ILE B 768 SHEET 1 AB9 4 TYR B 777 LYS B 779 0 SHEET 2 AB9 4 VAL B1150 ALA B1152 -1 O SER B1151 N PHE B 778 SHEET 3 AB9 4 GLY B1170 LYS B1174 -1 O LYS B1174 N VAL B1150 SHEET 4 AB9 4 TRP B1184 GLY B1188 -1 O SER B1185 N ILE B1173 SHEET 1 AC1 3 PHE B 788 VAL B 790 0 SHEET 2 AC1 3 GLY B1133 TYR B1141 -1 O GLY B1140 N GLY B 789 SHEET 3 AC1 3 GLU B 793 GLN B 796 -1 N ILE B 795 O LEU B1134 SHEET 1 AC2 3 PHE B 788 VAL B 790 0 SHEET 2 AC2 3 GLY B1133 TYR B1141 -1 O GLY B1140 N GLY B 789 SHEET 3 AC2 3 THR B1121 ALA B1130 -1 N VAL B1124 O VAL B1139 SHEET 1 AC3 2 VAL B 802 VAL B 804 0 SHEET 2 AC3 2 TYR B 932 VAL B 934 -1 O LYS B 933 N THR B 803 SHEET 1 AC4 2 GLN B 857 SER B 858 0 SHEET 2 AC4 2 ILE E 768 GLN E 769 1 O ILE E 768 N SER B 858 SHEET 1 AC5 4 THR B1202 VAL B1205 0 SHEET 2 AC5 4 CYS B1164 PRO B1167 -1 N CYS B1164 O VAL B1205 SHEET 3 AC5 4 LEU B1155 ASP B1157 -1 N LEU B1155 O ILE B1165 SHEET 4 AC5 4 GLN B1212 ILE B1214 1 O GLN B1212 N CYS B1156 SHEET 1 AC6 4 GLN A 3 SER A 7 0 SHEET 2 AC6 4 SER A 17 SER A 25 -1 O SER A 23 N GLN A 5 SHEET 3 AC6 4 VAL A 79 ASN A 84 -1 O MET A 83 N LEU A 18 SHEET 4 AC6 4 PHE A 68 PHE A 69 -1 N PHE A 69 O SER A 82 SHEET 1 AC7 5 THR A 58 TYR A 60 0 SHEET 2 AC7 5 GLU A 46 LYS A 52 -1 N PHE A 50 O ASP A 59 SHEET 3 AC7 5 CYS A 33 GLN A 39 -1 N TRP A 36 O LEU A 48 SHEET 4 AC7 5 ALA A 92 GLY A 98 -1 O TYR A 95 N PHE A 37 SHEET 5 AC7 5 TYR A 118 TRP A 119 -1 O TYR A 118 N GLY A 98 SHEET 1 AC8 5 THR A 58 TYR A 60 0 SHEET 2 AC8 5 GLU A 46 LYS A 52 -1 N PHE A 50 O ASP A 59 SHEET 3 AC8 5 CYS A 33 GLN A 39 -1 N TRP A 36 O LEU A 48 SHEET 4 AC8 5 ALA A 92 GLY A 98 -1 O TYR A 95 N PHE A 37 SHEET 5 AC8 5 THR A 123 VAL A 125 -1 O THR A 123 N TYR A 94 SHEET 1 AC9 3 VAL C 33 ILE C 35 0 SHEET 2 AC9 3 PRO C 97 VAL C 102 1 O VAL C 102 N ASP C 34 SHEET 3 AC9 3 HIS C 91 ALA C 92 -1 N HIS C 91 O LYS C 99 SHEET 1 AD1 3 ILE C 67 PHE C 75 0 SHEET 2 AD1 3 GLN C 319 PHE C 327 -1 O LEU C 325 N ILE C 69 SHEET 3 AD1 3 ILE C 333 ASP C 338 -1 O ILE C 337 N LEU C 324 SHEET 1 AD2 6 ASP C 83 TYR C 85 0 SHEET 2 AD2 6 PHE C 313 LYS C 317 -1 O PHE C 313 N TYR C 85 SHEET 3 AD2 6 PHE C 116 ILE C 120 -1 N VAL C 117 O TYR C 316 SHEET 4 AD2 6 GLU C 252 THR C 259 -1 O GLU C 252 N ILE C 120 SHEET 5 AD2 6 GLY C 262 SER C 267 -1 O GLY C 262 N THR C 259 SHEET 6 AD2 6 PHE C 279 LEU C 284 -1 O PHE C 281 N LEU C 265 SHEET 1 AD3 3 SER C 88 ALA C 89 0 SHEET 2 AD3 3 HIS C 298 ILE C 300 1 O ILE C 300 N SER C 88 SHEET 3 AD3 3 THR C 206 HIS C 208 1 N THR C 206 O SER C 299 SHEET 1 AD4 6 LYS C 110 GLN C 111 0 SHEET 2 AD4 6 TYR C 292 ILE C 295 -1 O TYR C 293 N LYS C 110 SHEET 3 AD4 6 PHE C 147 GLY C 150 -1 N GLY C 150 O TYR C 292 SHEET 4 AD4 6 THR C 168 ASP C 174 -1 O LEU C 169 N LEU C 149 SHEET 5 AD4 6 LEU C 179 PRO C 189 -1 O ARG C 181 N LEU C 172 SHEET 6 AD4 6 PHE C 232 ARG C 235 -1 O ASN C 233 N GLU C 188 SHEET 1 AD5 6 LYS C 110 GLN C 111 0 SHEET 2 AD5 6 TYR C 292 ILE C 295 -1 O TYR C 293 N LYS C 110 SHEET 3 AD5 6 PHE C 147 GLY C 150 -1 N GLY C 150 O TYR C 292 SHEET 4 AD5 6 THR C 168 ASP C 174 -1 O LEU C 169 N LEU C 149 SHEET 5 AD5 6 LEU C 179 PRO C 189 -1 O ARG C 181 N LEU C 172 SHEET 6 AD5 6 MET C 240 ASN C 244 -1 O TYR C 241 N ALA C 182 SHEET 1 AD6 3 THR C 127 THR C 129 0 SHEET 2 AD6 3 SER C 137 ARG C 141 -1 O ALA C 138 N GLY C 128 SHEET 3 AD6 3 ALA C 309 TRP C 310 1 O ALA C 309 N ARG C 141 SHEET 1 AD7 2 VAL C 153 ASN C 155 0 SHEET 2 AD7 2 MET C 161 PHE C 164 -1 O ARG C 163 N GLY C 154 SHEET 1 AD8 2 CYS C 214 SER C 215 0 SHEET 2 AD8 2 ASN C 218 TYR C 219 -1 O ASN C 218 N SER C 215 SHEET 1 AD9 6 TYR C 689 SER C 690 0 SHEET 2 AD9 6 SER C 362 ALA C 368 -1 N GLU C 367 O SER C 690 SHEET 3 AD9 6 SER C 656 ASP C 664 -1 O VAL C 657 N PHE C 366 SHEET 4 AD9 6 THR C 669 PHE C 674 -1 O ALA C 671 N ILE C 662 SHEET 5 AD9 6 GLY C 712 LEU C 715 -1 O CYS C 713 N PHE C 674 SHEET 6 AD9 6 LEU C 707 THR C 709 -1 N LEU C 707 O VAL C 714 SHEET 1 AE1 3 SER C 373 VAL C 375 0 SHEET 2 AE1 3 VAL C 604 SER C 607 1 O GLU C 605 N VAL C 374 SHEET 3 AE1 3 GLY C 613 GLY C 615 -1 O GLY C 613 N TYR C 606 SHEET 1 AE2 5 LYS C 400 PHE C 404 0 SHEET 2 AE2 5 SER C 440 SER C 447 -1 O LEU C 441 N PHE C 404 SHEET 3 AE2 5 GLN C 568 GLN C 576 -1 O THR C 574 N ILE C 442 SHEET 4 AE2 5 THR C 477 THR C 483 -1 N ILE C 480 O PHE C 571 SHEET 5 AE2 5 SER C 419 SER C 426 -1 N ASN C 421 O LEU C 481 SHEET 1 AE3 2 ASN C 408 TYR C 409 0 SHEET 2 AE3 2 CYS C 585 PRO C 586 1 O CYS C 585 N TYR C 409 SHEET 1 AE4 4 GLU C 513 PRO C 515 0 SHEET 2 AE4 4 TYR C 497 LEU C 506 -1 N ARG C 505 O VAL C 514 SHEET 3 AE4 4 TRP C 553 VAL C 561 -1 O TRP C 553 N LEU C 506 SHEET 4 AE4 4 ASP C 539 GLN C 544 -1 N LYS C 543 O LEU C 554 SHEET 1 AE5 3 PHE C 630 TYR C 632 0 SHEET 2 AE5 3 LEU C 638 TYR C 642 -1 O VAL C 639 N VAL C 631 SHEET 3 AE5 3 TYR C 648 TYR C 649 -1 O TYR C 649 N TYR C 641 SHEET 1 AE6 4 LEU C 717 VAL C 724 0 SHEET 2 AE6 4 MET C 757 ILE C 762 1 O LEU C 759 N VAL C 718 SHEET 3 AE6 4 LEU C 735 LEU C 738 -1 N LEU C 738 O ARG C 758 SHEET 4 AE6 4 PRO C 730 GLY C 732 -1 N LEU C 731 O LEU C 735 SHEET 1 AE7 2 ILE C 768 GLN C 769 0 SHEET 2 AE7 2 GLN E 857 SER E 858 1 O SER E 858 N ILE C 768 SHEET 1 AE8 4 TYR C 777 LYS C 779 0 SHEET 2 AE8 4 VAL C1150 ALA C1152 -1 O SER C1151 N PHE C 778 SHEET 3 AE8 4 GLY C1170 LYS C1174 -1 O LYS C1174 N VAL C1150 SHEET 4 AE8 4 TRP C1184 GLY C1188 -1 O SER C1185 N ILE C1173 SHEET 1 AE9 3 PHE C 788 VAL C 790 0 SHEET 2 AE9 3 GLY C1133 TYR C1141 -1 O GLY C1140 N GLY C 789 SHEET 3 AE9 3 GLU C 793 GLN C 796 -1 N ILE C 795 O LEU C1134 SHEET 1 AF1 3 PHE C 788 VAL C 790 0 SHEET 2 AF1 3 GLY C1133 TYR C1141 -1 O GLY C1140 N GLY C 789 SHEET 3 AF1 3 THR C1121 ALA C1130 -1 N VAL C1124 O VAL C1139 SHEET 1 AF2 2 VAL C 802 VAL C 804 0 SHEET 2 AF2 2 TYR C 932 VAL C 934 -1 O LYS C 933 N THR C 803 SHEET 1 AF3 4 THR C1202 VAL C1205 0 SHEET 2 AF3 4 CYS C1164 PRO C1167 -1 N CYS C1164 O VAL C1205 SHEET 3 AF3 4 LEU C1155 ASP C1157 -1 N LEU C1155 O ILE C1165 SHEET 4 AF3 4 GLN C1212 ILE C1214 1 O GLN C1212 N CYS C1156 SHEET 1 AF4 4 GLN D 3 SER D 7 0 SHEET 2 AF4 4 SER D 17 SER D 25 -1 O SER D 23 N GLN D 5 SHEET 3 AF4 4 VAL D 79 ASN D 84 -1 O MET D 83 N LEU D 18 SHEET 4 AF4 4 PHE D 68 PHE D 69 -1 N PHE D 69 O SER D 82 SHEET 1 AF5 5 THR D 58 TYR D 60 0 SHEET 2 AF5 5 GLU D 46 LYS D 52 -1 N PHE D 50 O ASP D 59 SHEET 3 AF5 5 CYS D 33 GLN D 39 -1 N TRP D 36 O LEU D 48 SHEET 4 AF5 5 ALA D 92 GLY D 98 -1 O TYR D 95 N PHE D 37 SHEET 5 AF5 5 TYR D 118 TRP D 119 -1 O TYR D 118 N GLY D 98 SHEET 1 AF6 5 THR D 58 TYR D 60 0 SHEET 2 AF6 5 GLU D 46 LYS D 52 -1 N PHE D 50 O ASP D 59 SHEET 3 AF6 5 CYS D 33 GLN D 39 -1 N TRP D 36 O LEU D 48 SHEET 4 AF6 5 ALA D 92 GLY D 98 -1 O TYR D 95 N PHE D 37 SHEET 5 AF6 5 THR D 123 VAL D 125 -1 O THR D 123 N TYR D 94 SHEET 1 AF7 3 VAL E 33 ILE E 35 0 SHEET 2 AF7 3 PRO E 97 VAL E 102 1 O VAL E 102 N ASP E 34 SHEET 3 AF7 3 HIS E 91 ALA E 92 -1 N HIS E 91 O LYS E 99 SHEET 1 AF8 3 ILE E 67 PHE E 75 0 SHEET 2 AF8 3 GLN E 319 PHE E 327 -1 O LEU E 325 N ILE E 69 SHEET 3 AF8 3 ILE E 333 ASP E 338 -1 O ILE E 337 N LEU E 324 SHEET 1 AF9 6 ASP E 83 TYR E 85 0 SHEET 2 AF9 6 PHE E 313 LYS E 317 -1 O PHE E 313 N TYR E 85 SHEET 3 AF9 6 PHE E 116 ILE E 120 -1 N VAL E 117 O TYR E 316 SHEET 4 AF9 6 GLU E 252 THR E 259 -1 O GLU E 252 N ILE E 120 SHEET 5 AF9 6 GLY E 262 SER E 267 -1 O GLY E 262 N THR E 259 SHEET 6 AF9 6 PHE E 279 LEU E 284 -1 O PHE E 281 N LEU E 265 SHEET 1 AG1 3 SER E 88 ALA E 89 0 SHEET 2 AG1 3 HIS E 298 ILE E 300 1 O ILE E 300 N SER E 88 SHEET 3 AG1 3 THR E 206 HIS E 208 1 N THR E 206 O SER E 299 SHEET 1 AG2 6 LYS E 110 GLN E 111 0 SHEET 2 AG2 6 TYR E 292 ILE E 295 -1 O TYR E 293 N LYS E 110 SHEET 3 AG2 6 PHE E 147 GLY E 150 -1 N GLY E 150 O TYR E 292 SHEET 4 AG2 6 THR E 168 ASP E 174 -1 O LEU E 169 N LEU E 149 SHEET 5 AG2 6 LEU E 179 PRO E 189 -1 O ARG E 181 N LEU E 172 SHEET 6 AG2 6 PHE E 232 ARG E 235 -1 O ASN E 233 N GLU E 188 SHEET 1 AG3 6 LYS E 110 GLN E 111 0 SHEET 2 AG3 6 TYR E 292 ILE E 295 -1 O TYR E 293 N LYS E 110 SHEET 3 AG3 6 PHE E 147 GLY E 150 -1 N GLY E 150 O TYR E 292 SHEET 4 AG3 6 THR E 168 ASP E 174 -1 O LEU E 169 N LEU E 149 SHEET 5 AG3 6 LEU E 179 PRO E 189 -1 O ARG E 181 N LEU E 172 SHEET 6 AG3 6 MET E 240 ASN E 244 -1 O TYR E 241 N ALA E 182 SHEET 1 AG4 3 THR E 127 THR E 129 0 SHEET 2 AG4 3 SER E 137 ARG E 141 -1 O ALA E 138 N GLY E 128 SHEET 3 AG4 3 ALA E 309 TRP E 310 1 O ALA E 309 N ARG E 141 SHEET 1 AG5 2 VAL E 153 ASN E 155 0 SHEET 2 AG5 2 MET E 161 PHE E 164 -1 O ARG E 163 N GLY E 154 SHEET 1 AG6 2 CYS E 214 SER E 215 0 SHEET 2 AG6 2 ASN E 218 TYR E 219 -1 O ASN E 218 N SER E 215 SHEET 1 AG7 6 TYR E 689 SER E 690 0 SHEET 2 AG7 6 SER E 362 ALA E 368 -1 N GLU E 367 O SER E 690 SHEET 3 AG7 6 SER E 656 ASP E 664 -1 O VAL E 657 N PHE E 366 SHEET 4 AG7 6 THR E 669 PHE E 674 -1 O ALA E 671 N ILE E 662 SHEET 5 AG7 6 GLY E 712 LEU E 715 -1 O CYS E 713 N PHE E 674 SHEET 6 AG7 6 LEU E 707 THR E 709 -1 N LEU E 707 O VAL E 714 SHEET 1 AG8 3 SER E 373 VAL E 375 0 SHEET 2 AG8 3 VAL E 604 SER E 607 1 O GLU E 605 N VAL E 374 SHEET 3 AG8 3 GLY E 613 GLY E 615 -1 O GLY E 613 N TYR E 606 SHEET 1 AG9 5 LYS E 400 PHE E 404 0 SHEET 2 AG9 5 SER E 440 SER E 447 -1 O LEU E 441 N PHE E 404 SHEET 3 AG9 5 GLN E 568 GLN E 576 -1 O THR E 574 N ILE E 442 SHEET 4 AG9 5 THR E 477 THR E 483 -1 N ILE E 480 O PHE E 571 SHEET 5 AG9 5 SER E 419 SER E 426 -1 N ASN E 421 O LEU E 481 SHEET 1 AH1 2 ASN E 408 TYR E 409 0 SHEET 2 AH1 2 CYS E 585 PRO E 586 1 O CYS E 585 N TYR E 409 SHEET 1 AH2 4 GLU E 513 PRO E 515 0 SHEET 2 AH2 4 TYR E 497 LEU E 506 -1 N ARG E 505 O VAL E 514 SHEET 3 AH2 4 TRP E 553 VAL E 561 -1 O TRP E 553 N LEU E 506 SHEET 4 AH2 4 ASP E 539 GLN E 544 -1 N LYS E 543 O LEU E 554 SHEET 1 AH3 3 PHE E 630 TYR E 632 0 SHEET 2 AH3 3 LEU E 638 TYR E 642 -1 O VAL E 639 N VAL E 631 SHEET 3 AH3 3 TYR E 648 TYR E 649 -1 O TYR E 649 N TYR E 641 SHEET 1 AH4 4 LEU E 717 VAL E 724 0 SHEET 2 AH4 4 MET E 757 ILE E 762 1 O LEU E 759 N VAL E 718 SHEET 3 AH4 4 LEU E 735 LEU E 738 -1 N LEU E 738 O ARG E 758 SHEET 4 AH4 4 PRO E 730 GLY E 732 -1 N LEU E 731 O LEU E 735 SHEET 1 AH5 4 TYR E 777 LYS E 779 0 SHEET 2 AH5 4 VAL E1150 ALA E1152 -1 O SER E1151 N PHE E 778 SHEET 3 AH5 4 GLY E1170 LYS E1174 -1 O LYS E1174 N VAL E1150 SHEET 4 AH5 4 TRP E1184 GLY E1188 -1 O SER E1185 N ILE E1173 SHEET 1 AH6 3 PHE E 788 VAL E 790 0 SHEET 2 AH6 3 GLY E1133 TYR E1141 -1 O GLY E1140 N GLY E 789 SHEET 3 AH6 3 GLU E 793 GLN E 796 -1 N ILE E 795 O LEU E1134 SHEET 1 AH7 3 PHE E 788 VAL E 790 0 SHEET 2 AH7 3 GLY E1133 TYR E1141 -1 O GLY E1140 N GLY E 789 SHEET 3 AH7 3 THR E1121 ALA E1130 -1 N VAL E1124 O VAL E1139 SHEET 1 AH8 2 VAL E 802 VAL E 804 0 SHEET 2 AH8 2 TYR E 932 VAL E 934 -1 O LYS E 933 N THR E 803 SHEET 1 AH9 4 THR E1202 VAL E1205 0 SHEET 2 AH9 4 CYS E1164 PRO E1167 -1 N CYS E1164 O VAL E1205 SHEET 3 AH9 4 LEU E1155 ASP E1157 -1 N LEU E1155 O ILE E1165 SHEET 4 AH9 4 GLN E1212 ILE E1214 1 O GLN E1212 N CYS E1156 SHEET 1 AI1 4 GLN F 3 SER F 7 0 SHEET 2 AI1 4 SER F 17 SER F 25 -1 O SER F 23 N GLN F 5 SHEET 3 AI1 4 VAL F 79 ASN F 84 -1 O MET F 83 N LEU F 18 SHEET 4 AI1 4 PHE F 68 PHE F 69 -1 N PHE F 69 O SER F 82 SHEET 1 AI2 5 THR F 58 TYR F 60 0 SHEET 2 AI2 5 GLU F 46 LYS F 52 -1 N PHE F 50 O ASP F 59 SHEET 3 AI2 5 CYS F 33 GLN F 39 -1 N TRP F 36 O LEU F 48 SHEET 4 AI2 5 ALA F 92 GLY F 98 -1 O TYR F 95 N PHE F 37 SHEET 5 AI2 5 TYR F 118 TRP F 119 -1 O TYR F 118 N GLY F 98 SHEET 1 AI3 5 THR F 58 TYR F 60 0 SHEET 2 AI3 5 GLU F 46 LYS F 52 -1 N PHE F 50 O ASP F 59 SHEET 3 AI3 5 CYS F 33 GLN F 39 -1 N TRP F 36 O LEU F 48 SHEET 4 AI3 5 ALA F 92 GLY F 98 -1 O TYR F 95 N PHE F 37 SHEET 5 AI3 5 THR F 123 VAL F 125 -1 O THR F 123 N TYR F 94 SSBOND 1 CYS B 30 CYS B 195 1555 1555 2.03 SSBOND 2 CYS B 176 CYS B 214 1555 1555 2.03 SSBOND 3 CYS B 185 CYS B 237 1555 1555 2.06 SSBOND 4 CYS B 339 CYS B 349 1555 1555 2.02 SSBOND 5 CYS B 383 CYS B 407 1555 1555 2.03 SSBOND 6 CYS B 425 CYS B 478 1555 1555 2.03 SSBOND 7 CYS B 437 CYS B 585 1555 1555 2.03 SSBOND 8 CYS B 503 CYS B 526 1555 1555 2.03 SSBOND 9 CYS B 603 CYS B 654 1555 1555 2.03 SSBOND 10 CYS B 620 CYS B 650 1555 1555 2.06 SSBOND 11 CYS B 679 CYS B 713 1555 1555 2.03 SSBOND 12 CYS B 727 CYS B 736 1555 1555 2.02 SSBOND 13 CYS B 806 CYS B 828 1555 1555 2.04 SSBOND 14 CYS B 811 CYS B 817 1555 1555 2.03 SSBOND 15 CYS B 912 CYS B 925 1555 1555 2.04 SSBOND 16 CYS B 1106 CYS B 1117 1555 1555 2.03 SSBOND 17 CYS B 1156 CYS B 1164 1555 1555 2.03 SSBOND 18 CYS A 22 CYS A 96 1555 1555 2.03 SSBOND 19 CYS A 33 CYS A 105 1555 1555 2.03 SSBOND 20 CYS C 30 CYS C 195 1555 1555 2.03 SSBOND 21 CYS C 176 CYS C 214 1555 1555 2.03 SSBOND 22 CYS C 185 CYS C 237 1555 1555 2.06 SSBOND 23 CYS C 339 CYS C 349 1555 1555 2.02 SSBOND 24 CYS C 383 CYS C 407 1555 1555 2.03 SSBOND 25 CYS C 425 CYS C 478 1555 1555 2.03 SSBOND 26 CYS C 437 CYS C 585 1555 1555 2.03 SSBOND 27 CYS C 503 CYS C 526 1555 1555 2.03 SSBOND 28 CYS C 603 CYS C 654 1555 1555 2.03 SSBOND 29 CYS C 620 CYS C 650 1555 1555 2.06 SSBOND 30 CYS C 679 CYS C 713 1555 1555 2.03 SSBOND 31 CYS C 727 CYS C 736 1555 1555 2.02 SSBOND 32 CYS C 806 CYS C 828 1555 1555 2.04 SSBOND 33 CYS C 811 CYS C 817 1555 1555 2.03 SSBOND 34 CYS C 912 CYS C 925 1555 1555 2.04 SSBOND 35 CYS C 1106 CYS C 1117 1555 1555 2.03 SSBOND 36 CYS C 1156 CYS C 1164 1555 1555 2.03 SSBOND 37 CYS D 22 CYS D 96 1555 1555 2.03 SSBOND 38 CYS D 33 CYS D 105 1555 1555 2.03 SSBOND 39 CYS E 30 CYS E 195 1555 1555 2.03 SSBOND 40 CYS E 176 CYS E 214 1555 1555 2.03 SSBOND 41 CYS E 185 CYS E 237 1555 1555 2.06 SSBOND 42 CYS E 339 CYS E 349 1555 1555 2.02 SSBOND 43 CYS E 383 CYS E 407 1555 1555 2.03 SSBOND 44 CYS E 425 CYS E 478 1555 1555 2.03 SSBOND 45 CYS E 437 CYS E 585 1555 1555 2.04 SSBOND 46 CYS E 503 CYS E 526 1555 1555 2.03 SSBOND 47 CYS E 603 CYS E 654 1555 1555 2.03 SSBOND 48 CYS E 620 CYS E 650 1555 1555 2.05 SSBOND 49 CYS E 679 CYS E 713 1555 1555 2.03 SSBOND 50 CYS E 727 CYS E 736 1555 1555 2.02 SSBOND 51 CYS E 806 CYS E 828 1555 1555 2.03 SSBOND 52 CYS E 811 CYS E 817 1555 1555 2.03 SSBOND 53 CYS E 912 CYS E 925 1555 1555 2.04 SSBOND 54 CYS E 1106 CYS E 1117 1555 1555 2.03 SSBOND 55 CYS E 1156 CYS E 1164 1555 1555 2.03 SSBOND 56 CYS F 22 CYS F 96 1555 1555 2.03 SSBOND 57 CYS F 33 CYS F 105 1555 1555 2.03 LINK ND2 ASN B 410 C1 NAG G 1 1555 1555 1.43 LINK ND2 ASN C 410 C1 NAG H 1 1555 1555 1.43 LINK ND2 ASN E 410 C1 NAG I 1 1555 1555 1.43 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.71 LINK O4 NAG G 2 C1 BMA G 3 1555 1555 1.44 LINK O3 BMA G 3 C1 MAN G 4 1555 1555 1.44 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.71 LINK O4 NAG H 2 C1 BMA H 3 1555 1555 1.44 LINK O3 BMA H 3 C1 MAN H 4 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.71 LINK O4 NAG I 2 C1 BMA I 3 1555 1555 1.44 LINK O3 BMA I 3 C1 MAN I 4 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000