HEADER MEMBRANE PROTEIN 08-MAY-23 8JBG TITLE NEUROKININ B BOUND TO ACTIVE HUMAN NEUROKININ 3 RECEPTOR IN COMPLEX TITLE 2 WITH GQ COMPND MOL_ID: 1; COMPND 2 MOLECULE: NEUROMEDIN-K RECEPTOR (NK3R-PFASTBAC1); COMPND 3 CHAIN: B; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) SUBUNIT COMPND 7 BETA-1; COMPND 8 CHAIN: D; COMPND 9 SYNONYM: TRANSDUCIN BETA CHAIN 1; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: SCFV16 NANOBODY; COMPND 13 CHAIN: E; COMPND 14 ENGINEERED: YES; COMPND 15 MOL_ID: 4; COMPND 16 MOLECULE: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(O) SUBUNIT COMPND 17 GAMMA-2; COMPND 18 CHAIN: G; COMPND 19 SYNONYM: G GAMMA-I; COMPND 20 ENGINEERED: YES; COMPND 21 MOL_ID: 5; COMPND 22 MOLECULE: NEUROKININ-B; COMPND 23 CHAIN: A; COMPND 24 SYNONYM: NKB,NEUROMEDIN-K; COMPND 25 ENGINEERED: YES; COMPND 26 MOL_ID: 6; COMPND 27 MOLECULE: GUANINE NUCLEOTIDE-BINDING PROTEIN GQ (G324); COMPND 28 CHAIN: C; COMPND 29 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: TACR3, NK3R, TAC3R; SOURCE 6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; SOURCE 10 ORGANISM_COMMON: NORWAY RAT; SOURCE 11 ORGANISM_TAXID: 10116; SOURCE 12 GENE: GNB1; SOURCE 13 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 17 ORGANISM_TAXID: 10090; SOURCE 18 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 20 MOL_ID: 4; SOURCE 21 ORGANISM_SCIENTIFIC: BOS TAURUS; SOURCE 22 ORGANISM_COMMON: CATTLE; SOURCE 23 ORGANISM_TAXID: 9913; SOURCE 24 GENE: GNG2; SOURCE 25 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 27 MOL_ID: 5; SOURCE 28 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 29 ORGANISM_COMMON: HUMAN; SOURCE 30 ORGANISM_TAXID: 9606; SOURCE 31 GENE: TAC3, NKNB, UNQ585/PRO1155; SOURCE 32 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 33 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 34 MOL_ID: 6; SOURCE 35 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 36 ORGANISM_TAXID: 9606; SOURCE 37 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 38 EXPRESSION_SYSTEM_TAXID: 7108 KEYWDS G PROTEIN COUPLED RECEPTOR, NEUROKININ, CRYO-EM, PEPTIDE AGONISTS, KEYWDS 2 MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR W.J.SUN,F.YANG,H.H.ZHANG,Q.N.YUAN,W.C.YIN,P.SHI,X.ERIC,C.L.TIAN JRNL AUTH W.SUN,F.YANG,H.ZHANG,Q.YUAN,S.LING,Y.WANG,P.LV,Z.LI,Y.LUO, JRNL AUTH 2 D.LIU,W.YIN,P.SHI,H.E.XU,C.TIAN JRNL TITL STRUCTURAL INSIGHTS INTO NEUROKININ 3 RECEPTOR ACTIVATION BY JRNL TITL 2 ENDOGENOUS AND ANALOGUE PEPTIDE AGONISTS. JRNL REF CELL DISCOV V. 9 66 2023 JRNL REFN ESSN 2056-5968 JRNL PMID 37391393 JRNL DOI 10.1038/S41421-023-00564-W REMARK 2 REMARK 2 RESOLUTION. 2.80 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.800 REMARK 3 NUMBER OF PARTICLES : 907878 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8JBG COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ. REMARK 100 THE DEPOSITION ID IS D_1300037560. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : NEUROKININ B BOUND TO ACTIVE REMARK 245 HUMAN NEUROKININ 3 RECEPTOR IN REMARK 245 COMPLEX WITH GQ HETEROTRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1200.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2200.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : DIFFRACTION REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 50.00 REMARK 245 ILLUMINATION MODE : SPOT SCAN REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, D, E, G, A, C REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET B -121 REMARK 465 LYS B -120 REMARK 465 THR B -119 REMARK 465 ILE B -118 REMARK 465 ILE B -117 REMARK 465 ALA B -116 REMARK 465 LEU B -115 REMARK 465 SER B -114 REMARK 465 TYR B -113 REMARK 465 ILE B -112 REMARK 465 PHE B -111 REMARK 465 CYS B -110 REMARK 465 LEU B -109 REMARK 465 VAL B -108 REMARK 465 PHE B -107 REMARK 465 ALA B -106 REMARK 465 ALA B -105 REMARK 465 ASP B -104 REMARK 465 LEU B -103 REMARK 465 GLU B -102 REMARK 465 ASP B -101 REMARK 465 ASN B -100 REMARK 465 TRP B -99 REMARK 465 GLU B -98 REMARK 465 THR B -97 REMARK 465 LEU B -96 REMARK 465 ASN B -95 REMARK 465 ASP B -94 REMARK 465 ASN B -93 REMARK 465 LEU B -92 REMARK 465 LYS B -91 REMARK 465 VAL B -90 REMARK 465 ILE B -89 REMARK 465 GLU B -88 REMARK 465 LYS B -87 REMARK 465 ALA B -86 REMARK 465 ASP B -85 REMARK 465 ASN B -84 REMARK 465 ALA B -83 REMARK 465 ALA B -82 REMARK 465 GLN B -81 REMARK 465 VAL B -80 REMARK 465 LYS B -79 REMARK 465 ASP B -78 REMARK 465 ALA B -77 REMARK 465 LEU B -76 REMARK 465 THR B -75 REMARK 465 LYS B -74 REMARK 465 MET B -73 REMARK 465 ARG B -72 REMARK 465 ALA B -71 REMARK 465 ALA B -70 REMARK 465 ALA B -69 REMARK 465 LEU B -68 REMARK 465 ASP B -67 REMARK 465 ALA B -66 REMARK 465 GLN B -65 REMARK 465 LYS B -64 REMARK 465 ALA B -63 REMARK 465 THR B -62 REMARK 465 PRO B -61 REMARK 465 PRO B -60 REMARK 465 LYS B -59 REMARK 465 LEU B -58 REMARK 465 GLU B -57 REMARK 465 ASP B -56 REMARK 465 LYS B -55 REMARK 465 SER B -54 REMARK 465 PRO B -53 REMARK 465 ASP B -52 REMARK 465 SER B -51 REMARK 465 PRO B -50 REMARK 465 GLU B -49 REMARK 465 MET B -48 REMARK 465 LYS B -47 REMARK 465 ASP B -46 REMARK 465 PHE B -45 REMARK 465 ARG B -44 REMARK 465 HIS B -43 REMARK 465 GLY B -42 REMARK 465 PHE B -41 REMARK 465 ASP B -40 REMARK 465 ILE B -39 REMARK 465 LEU B -38 REMARK 465 VAL B -37 REMARK 465 GLY B -36 REMARK 465 GLN B -35 REMARK 465 ILE B -34 REMARK 465 ASP B -33 REMARK 465 ASP B -32 REMARK 465 ALA B -31 REMARK 465 LEU B -30 REMARK 465 LYS B -29 REMARK 465 LEU B -28 REMARK 465 ALA B -27 REMARK 465 ASN B -26 REMARK 465 GLU B -25 REMARK 465 GLY B -24 REMARK 465 LYS B -23 REMARK 465 VAL B -22 REMARK 465 LYS B -21 REMARK 465 GLU B -20 REMARK 465 ALA B -19 REMARK 465 GLN B -18 REMARK 465 ALA B -17 REMARK 465 ALA B -16 REMARK 465 ALA B -15 REMARK 465 GLU B -14 REMARK 465 GLN B -13 REMARK 465 LEU B -12 REMARK 465 LYS B -11 REMARK 465 THR B -10 REMARK 465 THR B -9 REMARK 465 ARG B -8 REMARK 465 ASN B -7 REMARK 465 ALA B -6 REMARK 465 TYR B -5 REMARK 465 ILE B -4 REMARK 465 GLN B -3 REMARK 465 LYS B -2 REMARK 465 TYR B -1 REMARK 465 LEU B 0 REMARK 465 MET B 1 REMARK 465 ALA B 2 REMARK 465 THR B 3 REMARK 465 LEU B 4 REMARK 465 PRO B 5 REMARK 465 ALA B 6 REMARK 465 ALA B 7 REMARK 465 GLU B 8 REMARK 465 THR B 9 REMARK 465 TRP B 10 REMARK 465 ILE B 11 REMARK 465 ASP B 12 REMARK 465 GLY B 13 REMARK 465 GLY B 14 REMARK 465 GLY B 15 REMARK 465 GLY B 16 REMARK 465 VAL B 17 REMARK 465 GLY B 18 REMARK 465 ALA B 19 REMARK 465 ASP B 20 REMARK 465 ALA B 21 REMARK 465 VAL B 22 REMARK 465 ASN B 23 REMARK 465 LEU B 24 REMARK 465 THR B 25 REMARK 465 ALA B 26 REMARK 465 SER B 27 REMARK 465 LEU B 28 REMARK 465 ALA B 29 REMARK 465 ALA B 30 REMARK 465 GLY B 31 REMARK 465 ALA B 32 REMARK 465 ALA B 33 REMARK 465 THR B 34 REMARK 465 GLY B 35 REMARK 465 ALA B 36 REMARK 465 VAL B 37 REMARK 465 GLU B 38 REMARK 465 THR B 39 REMARK 465 GLY B 40 REMARK 465 TRP B 41 REMARK 465 LEU B 42 REMARK 465 GLN B 43 REMARK 465 LEU B 44 REMARK 465 LEU B 45 REMARK 465 ASP B 46 REMARK 465 GLN B 47 REMARK 465 ALA B 48 REMARK 465 GLY B 49 REMARK 465 ASN B 50 REMARK 465 LEU B 51 REMARK 465 SER B 52 REMARK 465 SER B 53 REMARK 465 SER B 54 REMARK 465 PRO B 55 REMARK 465 SER B 56 REMARK 465 ALA B 57 REMARK 465 LEU B 58 REMARK 465 GLY B 59 REMARK 465 LEU B 60 REMARK 465 PRO B 61 REMARK 465 VAL B 62 REMARK 465 ALA B 63 REMARK 465 SER B 64 REMARK 465 PRO B 65 REMARK 465 ALA B 66 REMARK 465 PRO B 67 REMARK 465 SER B 68 REMARK 465 GLN B 69 REMARK 465 PRO B 70 REMARK 465 TRP B 71 REMARK 465 ALA B 72 REMARK 465 ASN B 73 REMARK 465 LEU B 74 REMARK 465 THR B 75 REMARK 465 ARG B 115 REMARK 465 GLY B 276 REMARK 465 GLY B 277 REMARK 465 GLU B 278 REMARK 465 ILE B 279 REMARK 465 PRO B 280 REMARK 465 GLY B 281 REMARK 465 ASP B 282 REMARK 465 THR B 283 REMARK 465 CYS B 284 REMARK 465 ASP B 285 REMARK 465 LYS B 286 REMARK 465 TYR B 287 REMARK 465 HIS B 288 REMARK 465 GLU B 289 REMARK 465 ARG B 369 REMARK 465 ALA B 370 REMARK 465 PHE B 371 REMARK 465 ARG B 372 REMARK 465 TRP B 373 REMARK 465 CYS B 374 REMARK 465 PRO B 375 REMARK 465 PHE B 376 REMARK 465 ILE B 377 REMARK 465 LYS B 378 REMARK 465 VAL B 379 REMARK 465 SER B 380 REMARK 465 SER B 381 REMARK 465 TYR B 382 REMARK 465 ASP B 383 REMARK 465 GLU B 384 REMARK 465 LEU B 385 REMARK 465 GLU B 386 REMARK 465 LEU B 387 REMARK 465 LYS B 388 REMARK 465 THR B 389 REMARK 465 THR B 390 REMARK 465 ARG B 391 REMARK 465 PHE B 392 REMARK 465 HIS B 393 REMARK 465 PRO B 394 REMARK 465 VAL B 395 REMARK 465 PHE B 396 REMARK 465 THR B 397 REMARK 465 LEU B 398 REMARK 465 GLU B 399 REMARK 465 ASP B 400 REMARK 465 PHE B 401 REMARK 465 VAL B 402 REMARK 465 GLY B 403 REMARK 465 ASP B 404 REMARK 465 TRP B 405 REMARK 465 GLU B 406 REMARK 465 GLN B 407 REMARK 465 THR B 408 REMARK 465 ALA B 409 REMARK 465 ALA B 410 REMARK 465 TYR B 411 REMARK 465 ASN B 412 REMARK 465 LEU B 413 REMARK 465 ASP B 414 REMARK 465 GLN B 415 REMARK 465 VAL B 416 REMARK 465 LEU B 417 REMARK 465 GLU B 418 REMARK 465 GLN B 419 REMARK 465 GLY B 420 REMARK 465 GLY B 421 REMARK 465 VAL B 422 REMARK 465 SER B 423 REMARK 465 SER B 424 REMARK 465 LEU B 425 REMARK 465 LEU B 426 REMARK 465 GLN B 427 REMARK 465 ASN B 428 REMARK 465 LEU B 429 REMARK 465 ALA B 430 REMARK 465 VAL B 431 REMARK 465 SER B 432 REMARK 465 VAL B 433 REMARK 465 THR B 434 REMARK 465 PRO B 435 REMARK 465 ILE B 436 REMARK 465 GLN B 437 REMARK 465 ARG B 438 REMARK 465 ILE B 439 REMARK 465 VAL B 440 REMARK 465 ARG B 441 REMARK 465 SER B 442 REMARK 465 GLY B 443 REMARK 465 GLU B 444 REMARK 465 ASN B 445 REMARK 465 ALA B 446 REMARK 465 LEU B 447 REMARK 465 LYS B 448 REMARK 465 ILE B 449 REMARK 465 ASP B 450 REMARK 465 ILE B 451 REMARK 465 HIS B 452 REMARK 465 VAL B 453 REMARK 465 ILE B 454 REMARK 465 ILE B 455 REMARK 465 PRO B 456 REMARK 465 TYR B 457 REMARK 465 GLU B 458 REMARK 465 GLY B 459 REMARK 465 LEU B 460 REMARK 465 SER B 461 REMARK 465 ALA B 462 REMARK 465 ASP B 463 REMARK 465 GLN B 464 REMARK 465 MET B 465 REMARK 465 ALA B 466 REMARK 465 GLN B 467 REMARK 465 ILE B 468 REMARK 465 GLU B 469 REMARK 465 GLU B 470 REMARK 465 VAL B 471 REMARK 465 PHE B 472 REMARK 465 LYS B 473 REMARK 465 VAL B 474 REMARK 465 VAL B 475 REMARK 465 TYR B 476 REMARK 465 PRO B 477 REMARK 465 VAL B 478 REMARK 465 ASP B 479 REMARK 465 ASP B 480 REMARK 465 HIS B 481 REMARK 465 HIS B 482 REMARK 465 PHE B 483 REMARK 465 LYS B 484 REMARK 465 VAL B 485 REMARK 465 ILE B 486 REMARK 465 LEU B 487 REMARK 465 PRO B 488 REMARK 465 TYR B 489 REMARK 465 GLY B 490 REMARK 465 THR B 491 REMARK 465 LEU B 492 REMARK 465 VAL B 493 REMARK 465 ILE B 494 REMARK 465 ASP B 495 REMARK 465 GLY B 496 REMARK 465 VAL B 497 REMARK 465 THR B 498 REMARK 465 PRO B 499 REMARK 465 ASN B 500 REMARK 465 MET B 501 REMARK 465 LEU B 502 REMARK 465 ASN B 503 REMARK 465 TYR B 504 REMARK 465 PHE B 505 REMARK 465 GLY B 506 REMARK 465 ARG B 507 REMARK 465 PRO B 508 REMARK 465 TYR B 509 REMARK 465 GLU B 510 REMARK 465 GLY B 511 REMARK 465 ILE B 512 REMARK 465 ALA B 513 REMARK 465 VAL B 514 REMARK 465 PHE B 515 REMARK 465 ASP B 516 REMARK 465 GLY B 517 REMARK 465 LYS B 518 REMARK 465 LYS B 519 REMARK 465 ILE B 520 REMARK 465 THR B 521 REMARK 465 VAL B 522 REMARK 465 THR B 523 REMARK 465 GLY B 524 REMARK 465 THR B 525 REMARK 465 LEU B 526 REMARK 465 TRP B 527 REMARK 465 ASN B 528 REMARK 465 GLY B 529 REMARK 465 ASN B 530 REMARK 465 LYS B 531 REMARK 465 ILE B 532 REMARK 465 ILE B 533 REMARK 465 ASP B 534 REMARK 465 GLU B 535 REMARK 465 ARG B 536 REMARK 465 LEU B 537 REMARK 465 ILE B 538 REMARK 465 THR B 539 REMARK 465 PRO B 540 REMARK 465 ASP B 541 REMARK 465 GLY B 542 REMARK 465 SER B 543 REMARK 465 MET B 544 REMARK 465 LEU B 545 REMARK 465 PHE B 546 REMARK 465 ARG B 547 REMARK 465 VAL B 548 REMARK 465 THR B 549 REMARK 465 ILE B 550 REMARK 465 ASN B 551 REMARK 465 SER B 552 REMARK 465 GLY B 553 REMARK 465 GLY B 554 REMARK 465 SER B 555 REMARK 465 GLU B 556 REMARK 465 ASN B 557 REMARK 465 LEU B 558 REMARK 465 TYR B 559 REMARK 465 PHE B 560 REMARK 465 GLN B 561 REMARK 465 GLY B 562 REMARK 465 GLY B 563 REMARK 465 SER B 564 REMARK 465 ALA B 565 REMARK 465 GLY B 566 REMARK 465 SER B 567 REMARK 465 ALA B 568 REMARK 465 ALA B 569 REMARK 465 LYS B 570 REMARK 465 ILE B 571 REMARK 465 GLU B 572 REMARK 465 GLU B 573 REMARK 465 GLY B 574 REMARK 465 LYS B 575 REMARK 465 LEU B 576 REMARK 465 VAL B 577 REMARK 465 ILE B 578 REMARK 465 TRP B 579 REMARK 465 ILE B 580 REMARK 465 ASN B 581 REMARK 465 GLY B 582 REMARK 465 ASP B 583 REMARK 465 LYS B 584 REMARK 465 GLY B 585 REMARK 465 TYR B 586 REMARK 465 ASN B 587 REMARK 465 GLY B 588 REMARK 465 LEU B 589 REMARK 465 ALA B 590 REMARK 465 GLU B 591 REMARK 465 VAL B 592 REMARK 465 GLY B 593 REMARK 465 LYS B 594 REMARK 465 LYS B 595 REMARK 465 PHE B 596 REMARK 465 GLU B 597 REMARK 465 LYS B 598 REMARK 465 ASP B 599 REMARK 465 THR B 600 REMARK 465 GLY B 601 REMARK 465 ILE B 602 REMARK 465 LYS B 603 REMARK 465 VAL B 604 REMARK 465 THR B 605 REMARK 465 VAL B 606 REMARK 465 GLU B 607 REMARK 465 HIS B 608 REMARK 465 PRO B 609 REMARK 465 ASP B 610 REMARK 465 LYS B 611 REMARK 465 LEU B 612 REMARK 465 GLU B 613 REMARK 465 GLU B 614 REMARK 465 LYS B 615 REMARK 465 PHE B 616 REMARK 465 PRO B 617 REMARK 465 GLN B 618 REMARK 465 VAL B 619 REMARK 465 ALA B 620 REMARK 465 ALA B 621 REMARK 465 THR B 622 REMARK 465 GLY B 623 REMARK 465 ASP B 624 REMARK 465 GLY B 625 REMARK 465 PRO B 626 REMARK 465 ASP B 627 REMARK 465 ILE B 628 REMARK 465 ILE B 629 REMARK 465 PHE B 630 REMARK 465 TRP B 631 REMARK 465 ALA B 632 REMARK 465 HIS B 633 REMARK 465 ASP B 634 REMARK 465 ARG B 635 REMARK 465 PHE B 636 REMARK 465 GLY B 637 REMARK 465 GLY B 638 REMARK 465 TYR B 639 REMARK 465 ALA B 640 REMARK 465 GLN B 641 REMARK 465 SER B 642 REMARK 465 GLY B 643 REMARK 465 LEU B 644 REMARK 465 LEU B 645 REMARK 465 ALA B 646 REMARK 465 GLU B 647 REMARK 465 ILE B 648 REMARK 465 THR B 649 REMARK 465 PRO B 650 REMARK 465 ASP B 651 REMARK 465 LYS B 652 REMARK 465 ALA B 653 REMARK 465 PHE B 654 REMARK 465 GLN B 655 REMARK 465 ASP B 656 REMARK 465 LYS B 657 REMARK 465 LEU B 658 REMARK 465 TYR B 659 REMARK 465 PRO B 660 REMARK 465 PHE B 661 REMARK 465 THR B 662 REMARK 465 TRP B 663 REMARK 465 ASP B 664 REMARK 465 ALA B 665 REMARK 465 VAL B 666 REMARK 465 ARG B 667 REMARK 465 TYR B 668 REMARK 465 ASN B 669 REMARK 465 GLY B 670 REMARK 465 LYS B 671 REMARK 465 LEU B 672 REMARK 465 ILE B 673 REMARK 465 ALA B 674 REMARK 465 TYR B 675 REMARK 465 PRO B 676 REMARK 465 ILE B 677 REMARK 465 ALA B 678 REMARK 465 VAL B 679 REMARK 465 GLU B 680 REMARK 465 ALA B 681 REMARK 465 LEU B 682 REMARK 465 SER B 683 REMARK 465 LEU B 684 REMARK 465 ILE B 685 REMARK 465 TYR B 686 REMARK 465 ASN B 687 REMARK 465 LYS B 688 REMARK 465 ASP B 689 REMARK 465 LEU B 690 REMARK 465 LEU B 691 REMARK 465 PRO B 692 REMARK 465 ASN B 693 REMARK 465 PRO B 694 REMARK 465 PRO B 695 REMARK 465 LYS B 696 REMARK 465 THR B 697 REMARK 465 TRP B 698 REMARK 465 GLU B 699 REMARK 465 GLU B 700 REMARK 465 ILE B 701 REMARK 465 PRO B 702 REMARK 465 ALA B 703 REMARK 465 LEU B 704 REMARK 465 ASP B 705 REMARK 465 LYS B 706 REMARK 465 GLU B 707 REMARK 465 LEU B 708 REMARK 465 LYS B 709 REMARK 465 ALA B 710 REMARK 465 LYS B 711 REMARK 465 GLY B 712 REMARK 465 LYS B 713 REMARK 465 SER B 714 REMARK 465 ALA B 715 REMARK 465 LEU B 716 REMARK 465 MET B 717 REMARK 465 PHE B 718 REMARK 465 ASN B 719 REMARK 465 LEU B 720 REMARK 465 GLN B 721 REMARK 465 GLU B 722 REMARK 465 PRO B 723 REMARK 465 TYR B 724 REMARK 465 PHE B 725 REMARK 465 THR B 726 REMARK 465 TRP B 727 REMARK 465 PRO B 728 REMARK 465 LEU B 729 REMARK 465 ILE B 730 REMARK 465 ALA B 731 REMARK 465 ALA B 732 REMARK 465 ASP B 733 REMARK 465 GLY B 734 REMARK 465 GLY B 735 REMARK 465 TYR B 736 REMARK 465 ALA B 737 REMARK 465 PHE B 738 REMARK 465 LYS B 739 REMARK 465 TYR B 740 REMARK 465 GLU B 741 REMARK 465 ASN B 742 REMARK 465 GLY B 743 REMARK 465 LYS B 744 REMARK 465 TYR B 745 REMARK 465 ASP B 746 REMARK 465 ILE B 747 REMARK 465 LYS B 748 REMARK 465 ASP B 749 REMARK 465 VAL B 750 REMARK 465 GLY B 751 REMARK 465 VAL B 752 REMARK 465 ASP B 753 REMARK 465 ASN B 754 REMARK 465 ALA B 755 REMARK 465 GLY B 756 REMARK 465 ALA B 757 REMARK 465 LYS B 758 REMARK 465 ALA B 759 REMARK 465 GLY B 760 REMARK 465 LEU B 761 REMARK 465 THR B 762 REMARK 465 PHE B 763 REMARK 465 LEU B 764 REMARK 465 VAL B 765 REMARK 465 ASP B 766 REMARK 465 LEU B 767 REMARK 465 ILE B 768 REMARK 465 LYS B 769 REMARK 465 ASN B 770 REMARK 465 LYS B 771 REMARK 465 HIS B 772 REMARK 465 MET B 773 REMARK 465 ASN B 774 REMARK 465 ALA B 775 REMARK 465 ASP B 776 REMARK 465 THR B 777 REMARK 465 ASP B 778 REMARK 465 TYR B 779 REMARK 465 SER B 780 REMARK 465 ILE B 781 REMARK 465 ALA B 782 REMARK 465 GLU B 783 REMARK 465 ALA B 784 REMARK 465 ALA B 785 REMARK 465 PHE B 786 REMARK 465 ASN B 787 REMARK 465 LYS B 788 REMARK 465 GLY B 789 REMARK 465 GLU B 790 REMARK 465 THR B 791 REMARK 465 ALA B 792 REMARK 465 MET B 793 REMARK 465 THR B 794 REMARK 465 ILE B 795 REMARK 465 ASN B 796 REMARK 465 GLY B 797 REMARK 465 PRO B 798 REMARK 465 TRP B 799 REMARK 465 ALA B 800 REMARK 465 TRP B 801 REMARK 465 SER B 802 REMARK 465 ASN B 803 REMARK 465 ILE B 804 REMARK 465 ASP B 805 REMARK 465 THR B 806 REMARK 465 SER B 807 REMARK 465 LYS B 808 REMARK 465 VAL B 809 REMARK 465 ASN B 810 REMARK 465 TYR B 811 REMARK 465 GLY B 812 REMARK 465 VAL B 813 REMARK 465 THR B 814 REMARK 465 VAL B 815 REMARK 465 LEU B 816 REMARK 465 PRO B 817 REMARK 465 THR B 818 REMARK 465 PHE B 819 REMARK 465 LYS B 820 REMARK 465 GLY B 821 REMARK 465 GLN B 822 REMARK 465 PRO B 823 REMARK 465 SER B 824 REMARK 465 LYS B 825 REMARK 465 PRO B 826 REMARK 465 PHE B 827 REMARK 465 VAL B 828 REMARK 465 GLY B 829 REMARK 465 VAL B 830 REMARK 465 LEU B 831 REMARK 465 SER B 832 REMARK 465 ALA B 833 REMARK 465 GLY B 834 REMARK 465 ILE B 835 REMARK 465 ASN B 836 REMARK 465 ALA B 837 REMARK 465 ALA B 838 REMARK 465 SER B 839 REMARK 465 PRO B 840 REMARK 465 ASN B 841 REMARK 465 LYS B 842 REMARK 465 GLU B 843 REMARK 465 LEU B 844 REMARK 465 ALA B 845 REMARK 465 LYS B 846 REMARK 465 GLU B 847 REMARK 465 PHE B 848 REMARK 465 LEU B 849 REMARK 465 GLU B 850 REMARK 465 ASN B 851 REMARK 465 TYR B 852 REMARK 465 LEU B 853 REMARK 465 LEU B 854 REMARK 465 THR B 855 REMARK 465 ASP B 856 REMARK 465 GLU B 857 REMARK 465 GLY B 858 REMARK 465 LEU B 859 REMARK 465 GLU B 860 REMARK 465 ALA B 861 REMARK 465 VAL B 862 REMARK 465 ASN B 863 REMARK 465 LYS B 864 REMARK 465 ASP B 865 REMARK 465 LYS B 866 REMARK 465 PRO B 867 REMARK 465 LEU B 868 REMARK 465 GLY B 869 REMARK 465 ALA B 870 REMARK 465 VAL B 871 REMARK 465 ALA B 872 REMARK 465 LEU B 873 REMARK 465 LYS B 874 REMARK 465 SER B 875 REMARK 465 TYR B 876 REMARK 465 GLU B 877 REMARK 465 GLU B 878 REMARK 465 GLU B 879 REMARK 465 LEU B 880 REMARK 465 ALA B 881 REMARK 465 LYS B 882 REMARK 465 ASP B 883 REMARK 465 PRO B 884 REMARK 465 ARG B 885 REMARK 465 ILE B 886 REMARK 465 ALA B 887 REMARK 465 ALA B 888 REMARK 465 THR B 889 REMARK 465 MET B 890 REMARK 465 GLU B 891 REMARK 465 ASN B 892 REMARK 465 ALA B 893 REMARK 465 GLN B 894 REMARK 465 LYS B 895 REMARK 465 GLY B 896 REMARK 465 GLU B 897 REMARK 465 ILE B 898 REMARK 465 MET B 899 REMARK 465 PRO B 900 REMARK 465 ASN B 901 REMARK 465 ILE B 902 REMARK 465 PRO B 903 REMARK 465 GLN B 904 REMARK 465 MET B 905 REMARK 465 SER B 906 REMARK 465 ALA B 907 REMARK 465 PHE B 908 REMARK 465 TRP B 909 REMARK 465 TYR B 910 REMARK 465 ALA B 911 REMARK 465 VAL B 912 REMARK 465 ARG B 913 REMARK 465 THR B 914 REMARK 465 ALA B 915 REMARK 465 VAL B 916 REMARK 465 ILE B 917 REMARK 465 ASN B 918 REMARK 465 ALA B 919 REMARK 465 ALA B 920 REMARK 465 SER B 921 REMARK 465 GLY B 922 REMARK 465 ARG B 923 REMARK 465 GLN B 924 REMARK 465 THR B 925 REMARK 465 VAL B 926 REMARK 465 ASP B 927 REMARK 465 GLU B 928 REMARK 465 ALA B 929 REMARK 465 LEU B 930 REMARK 465 LYS B 931 REMARK 465 ASP B 932 REMARK 465 ALA B 933 REMARK 465 GLN B 934 REMARK 465 THR B 935 REMARK 465 ALA B 936 REMARK 465 LYS B 937 REMARK 465 ILE B 938 REMARK 465 GLU B 939 REMARK 465 GLU B 940 REMARK 465 GLY B 941 REMARK 465 LYS B 942 REMARK 465 LEU B 943 REMARK 465 VAL B 944 REMARK 465 ILE B 945 REMARK 465 TRP B 946 REMARK 465 ILE B 947 REMARK 465 ASN B 948 REMARK 465 GLY B 949 REMARK 465 ASP B 950 REMARK 465 LYS B 951 REMARK 465 GLY B 952 REMARK 465 TYR B 953 REMARK 465 ASN B 954 REMARK 465 GLY B 955 REMARK 465 LEU B 956 REMARK 465 ALA B 957 REMARK 465 GLU B 958 REMARK 465 VAL B 959 REMARK 465 GLY B 960 REMARK 465 LYS B 961 REMARK 465 LYS B 962 REMARK 465 PHE B 963 REMARK 465 GLU B 964 REMARK 465 LYS B 965 REMARK 465 ASP B 966 REMARK 465 THR B 967 REMARK 465 GLY B 968 REMARK 465 ILE B 969 REMARK 465 LYS B 970 REMARK 465 VAL B 971 REMARK 465 THR B 972 REMARK 465 VAL B 973 REMARK 465 GLU B 974 REMARK 465 HIS B 975 REMARK 465 PRO B 976 REMARK 465 ASP B 977 REMARK 465 LYS B 978 REMARK 465 LEU B 979 REMARK 465 GLU B 980 REMARK 465 GLU B 981 REMARK 465 LYS B 982 REMARK 465 PHE B 983 REMARK 465 PRO B 984 REMARK 465 GLN B 985 REMARK 465 VAL B 986 REMARK 465 ALA B 987 REMARK 465 ALA B 988 REMARK 465 THR B 989 REMARK 465 GLY B 990 REMARK 465 ASP B 991 REMARK 465 GLY B 992 REMARK 465 PRO B 993 REMARK 465 ASP B 994 REMARK 465 ILE B 995 REMARK 465 ILE B 996 REMARK 465 PHE B 997 REMARK 465 TRP B 998 REMARK 465 ALA B 999 REMARK 465 HIS B 1000 REMARK 465 ASP B 1001 REMARK 465 ARG B 1002 REMARK 465 PHE B 1003 REMARK 465 GLY B 1004 REMARK 465 GLY B 1005 REMARK 465 TYR B 1006 REMARK 465 ALA B 1007 REMARK 465 GLN B 1008 REMARK 465 SER B 1009 REMARK 465 GLY B 1010 REMARK 465 LEU B 1011 REMARK 465 LEU B 1012 REMARK 465 ALA B 1013 REMARK 465 GLU B 1014 REMARK 465 ILE B 1015 REMARK 465 THR B 1016 REMARK 465 PRO B 1017 REMARK 465 ASP B 1018 REMARK 465 LYS B 1019 REMARK 465 ALA B 1020 REMARK 465 PHE B 1021 REMARK 465 GLN B 1022 REMARK 465 ASP B 1023 REMARK 465 LYS B 1024 REMARK 465 LEU B 1025 REMARK 465 TYR B 1026 REMARK 465 PRO B 1027 REMARK 465 PHE B 1028 REMARK 465 THR B 1029 REMARK 465 TRP B 1030 REMARK 465 ASP B 1031 REMARK 465 ALA B 1032 REMARK 465 VAL B 1033 REMARK 465 ARG B 1034 REMARK 465 TYR B 1035 REMARK 465 ASN B 1036 REMARK 465 GLY B 1037 REMARK 465 LYS B 1038 REMARK 465 LEU B 1039 REMARK 465 ILE B 1040 REMARK 465 ALA B 1041 REMARK 465 TYR B 1042 REMARK 465 PRO B 1043 REMARK 465 ILE B 1044 REMARK 465 ALA B 1045 REMARK 465 VAL B 1046 REMARK 465 GLU B 1047 REMARK 465 ALA B 1048 REMARK 465 LEU B 1049 REMARK 465 SER B 1050 REMARK 465 LEU B 1051 REMARK 465 ILE B 1052 REMARK 465 TYR B 1053 REMARK 465 ASN B 1054 REMARK 465 LYS B 1055 REMARK 465 ASP B 1056 REMARK 465 LEU B 1057 REMARK 465 LEU B 1058 REMARK 465 PRO B 1059 REMARK 465 ASN B 1060 REMARK 465 PRO B 1061 REMARK 465 PRO B 1062 REMARK 465 LYS B 1063 REMARK 465 THR B 1064 REMARK 465 TRP B 1065 REMARK 465 GLU B 1066 REMARK 465 GLU B 1067 REMARK 465 ILE B 1068 REMARK 465 PRO B 1069 REMARK 465 ALA B 1070 REMARK 465 LEU B 1071 REMARK 465 ASP B 1072 REMARK 465 LYS B 1073 REMARK 465 GLU B 1074 REMARK 465 LEU B 1075 REMARK 465 LYS B 1076 REMARK 465 ALA B 1077 REMARK 465 LYS B 1078 REMARK 465 GLY B 1079 REMARK 465 LYS B 1080 REMARK 465 SER B 1081 REMARK 465 ALA B 1082 REMARK 465 LEU B 1083 REMARK 465 MET B 1084 REMARK 465 PHE B 1085 REMARK 465 ASN B 1086 REMARK 465 LEU B 1087 REMARK 465 GLN B 1088 REMARK 465 GLU B 1089 REMARK 465 PRO B 1090 REMARK 465 TYR B 1091 REMARK 465 PHE B 1092 REMARK 465 THR B 1093 REMARK 465 TRP B 1094 REMARK 465 PRO B 1095 REMARK 465 LEU B 1096 REMARK 465 ILE B 1097 REMARK 465 ALA B 1098 REMARK 465 ALA B 1099 REMARK 465 ASP B 1100 REMARK 465 GLY B 1101 REMARK 465 GLY B 1102 REMARK 465 TYR B 1103 REMARK 465 ALA B 1104 REMARK 465 PHE B 1105 REMARK 465 LYS B 1106 REMARK 465 TYR B 1107 REMARK 465 GLU B 1108 REMARK 465 ASN B 1109 REMARK 465 GLY B 1110 REMARK 465 LYS B 1111 REMARK 465 TYR B 1112 REMARK 465 ASP B 1113 REMARK 465 ILE B 1114 REMARK 465 LYS B 1115 REMARK 465 ASP B 1116 REMARK 465 VAL B 1117 REMARK 465 GLY B 1118 REMARK 465 VAL B 1119 REMARK 465 ASP B 1120 REMARK 465 ASN B 1121 REMARK 465 ALA B 1122 REMARK 465 GLY B 1123 REMARK 465 ALA B 1124 REMARK 465 LYS B 1125 REMARK 465 ALA B 1126 REMARK 465 GLY B 1127 REMARK 465 LEU B 1128 REMARK 465 THR B 1129 REMARK 465 PHE B 1130 REMARK 465 LEU B 1131 REMARK 465 VAL B 1132 REMARK 465 ASP B 1133 REMARK 465 LEU B 1134 REMARK 465 ILE B 1135 REMARK 465 LYS B 1136 REMARK 465 ASN B 1137 REMARK 465 LYS B 1138 REMARK 465 HIS B 1139 REMARK 465 MET B 1140 REMARK 465 ASN B 1141 REMARK 465 ALA B 1142 REMARK 465 ASP B 1143 REMARK 465 THR B 1144 REMARK 465 ASP B 1145 REMARK 465 TYR B 1146 REMARK 465 SER B 1147 REMARK 465 ILE B 1148 REMARK 465 ALA B 1149 REMARK 465 GLU B 1150 REMARK 465 ALA B 1151 REMARK 465 ALA B 1152 REMARK 465 PHE B 1153 REMARK 465 ASN B 1154 REMARK 465 LYS B 1155 REMARK 465 GLY B 1156 REMARK 465 GLU B 1157 REMARK 465 THR B 1158 REMARK 465 ALA B 1159 REMARK 465 MET B 1160 REMARK 465 THR B 1161 REMARK 465 ILE B 1162 REMARK 465 ASN B 1163 REMARK 465 GLY B 1164 REMARK 465 PRO B 1165 REMARK 465 TRP B 1166 REMARK 465 ALA B 1167 REMARK 465 TRP B 1168 REMARK 465 SER B 1169 REMARK 465 ASN B 1170 REMARK 465 ILE B 1171 REMARK 465 ASP B 1172 REMARK 465 THR B 1173 REMARK 465 SER B 1174 REMARK 465 LYS B 1175 REMARK 465 VAL B 1176 REMARK 465 ASN B 1177 REMARK 465 TYR B 1178 REMARK 465 GLY B 1179 REMARK 465 VAL B 1180 REMARK 465 THR B 1181 REMARK 465 VAL B 1182 REMARK 465 LEU B 1183 REMARK 465 PRO B 1184 REMARK 465 THR B 1185 REMARK 465 PHE B 1186 REMARK 465 LYS B 1187 REMARK 465 GLY B 1188 REMARK 465 GLN B 1189 REMARK 465 PRO B 1190 REMARK 465 SER B 1191 REMARK 465 LYS B 1192 REMARK 465 PRO B 1193 REMARK 465 PHE B 1194 REMARK 465 VAL B 1195 REMARK 465 GLY B 1196 REMARK 465 VAL B 1197 REMARK 465 LEU B 1198 REMARK 465 SER B 1199 REMARK 465 ALA B 1200 REMARK 465 GLY B 1201 REMARK 465 ILE B 1202 REMARK 465 ASN B 1203 REMARK 465 ALA B 1204 REMARK 465 ALA B 1205 REMARK 465 SER B 1206 REMARK 465 PRO B 1207 REMARK 465 ASN B 1208 REMARK 465 LYS B 1209 REMARK 465 GLU B 1210 REMARK 465 LEU B 1211 REMARK 465 ALA B 1212 REMARK 465 LYS B 1213 REMARK 465 GLU B 1214 REMARK 465 PHE B 1215 REMARK 465 LEU B 1216 REMARK 465 GLU B 1217 REMARK 465 ASN B 1218 REMARK 465 TYR B 1219 REMARK 465 LEU B 1220 REMARK 465 LEU B 1221 REMARK 465 THR B 1222 REMARK 465 ASP B 1223 REMARK 465 GLU B 1224 REMARK 465 GLY B 1225 REMARK 465 LEU B 1226 REMARK 465 GLU B 1227 REMARK 465 ALA B 1228 REMARK 465 VAL B 1229 REMARK 465 ASN B 1230 REMARK 465 LYS B 1231 REMARK 465 ASP B 1232 REMARK 465 LYS B 1233 REMARK 465 PRO B 1234 REMARK 465 LEU B 1235 REMARK 465 GLY B 1236 REMARK 465 ALA B 1237 REMARK 465 VAL B 1238 REMARK 465 ALA B 1239 REMARK 465 LEU B 1240 REMARK 465 LYS B 1241 REMARK 465 SER B 1242 REMARK 465 TYR B 1243 REMARK 465 GLU B 1244 REMARK 465 GLU B 1245 REMARK 465 GLU B 1246 REMARK 465 LEU B 1247 REMARK 465 ALA B 1248 REMARK 465 LYS B 1249 REMARK 465 ASP B 1250 REMARK 465 PRO B 1251 REMARK 465 ARG B 1252 REMARK 465 ILE B 1253 REMARK 465 ALA B 1254 REMARK 465 ALA B 1255 REMARK 465 THR B 1256 REMARK 465 MET B 1257 REMARK 465 GLU B 1258 REMARK 465 ASN B 1259 REMARK 465 ALA B 1260 REMARK 465 GLN B 1261 REMARK 465 LYS B 1262 REMARK 465 GLY B 1263 REMARK 465 GLU B 1264 REMARK 465 ILE B 1265 REMARK 465 MET B 1266 REMARK 465 PRO B 1267 REMARK 465 ASN B 1268 REMARK 465 ILE B 1269 REMARK 465 PRO B 1270 REMARK 465 GLN B 1271 REMARK 465 MET B 1272 REMARK 465 SER B 1273 REMARK 465 ALA B 1274 REMARK 465 PHE B 1275 REMARK 465 TRP B 1276 REMARK 465 TYR B 1277 REMARK 465 ALA B 1278 REMARK 465 VAL B 1279 REMARK 465 ARG B 1280 REMARK 465 THR B 1281 REMARK 465 ALA B 1282 REMARK 465 VAL B 1283 REMARK 465 ILE B 1284 REMARK 465 ASN B 1285 REMARK 465 ALA B 1286 REMARK 465 ALA B 1287 REMARK 465 SER B 1288 REMARK 465 GLY B 1289 REMARK 465 ARG B 1290 REMARK 465 GLN B 1291 REMARK 465 THR B 1292 REMARK 465 VAL B 1293 REMARK 465 ASP B 1294 REMARK 465 GLU B 1295 REMARK 465 ALA B 1296 REMARK 465 LEU B 1297 REMARK 465 LYS B 1298 REMARK 465 ASP B 1299 REMARK 465 ALA B 1300 REMARK 465 GLN B 1301 REMARK 465 THR B 1302 REMARK 465 ARG B 1303 REMARK 465 ILE B 1304 REMARK 465 THR B 1305 REMARK 465 LYS B 1306 REMARK 465 HIS D -10 REMARK 465 MET D -9 REMARK 465 HIS D -8 REMARK 465 HIS D -7 REMARK 465 HIS D -6 REMARK 465 HIS D -5 REMARK 465 HIS D -4 REMARK 465 GLY D -3 REMARK 465 SER D -2 REMARK 465 LEU D -1 REMARK 465 LEU D 0 REMARK 465 GLN D 1 REMARK 465 SER D 2 REMARK 465 GLY D 341 REMARK 465 SER D 342 REMARK 465 SER D 343 REMARK 465 GLY D 344 REMARK 465 GLY D 345 REMARK 465 GLY D 346 REMARK 465 GLY D 347 REMARK 465 SER D 348 REMARK 465 GLY D 349 REMARK 465 GLY D 350 REMARK 465 GLY D 351 REMARK 465 GLY D 352 REMARK 465 SER D 353 REMARK 465 SER D 354 REMARK 465 GLY D 355 REMARK 465 VAL D 356 REMARK 465 SER D 357 REMARK 465 GLY D 358 REMARK 465 TRP D 359 REMARK 465 ARG D 360 REMARK 465 LEU D 361 REMARK 465 PHE D 362 REMARK 465 LYS D 363 REMARK 465 LYS D 364 REMARK 465 ILE D 365 REMARK 465 SER D 366 REMARK 465 MET E -36 REMARK 465 LEU E -35 REMARK 465 LEU E -34 REMARK 465 VAL E -33 REMARK 465 ASN E -32 REMARK 465 GLN E -31 REMARK 465 SER E -30 REMARK 465 HIS E -29 REMARK 465 GLN E -28 REMARK 465 GLY E -27 REMARK 465 PHE E -26 REMARK 465 ASN E -25 REMARK 465 LYS E -24 REMARK 465 GLU E -23 REMARK 465 HIS E -22 REMARK 465 THR E -21 REMARK 465 SER E -20 REMARK 465 LYS E -19 REMARK 465 MET E -18 REMARK 465 VAL E -17 REMARK 465 SER E -16 REMARK 465 ALA E -15 REMARK 465 ILE E -14 REMARK 465 VAL E -13 REMARK 465 LEU E -12 REMARK 465 TYR E -11 REMARK 465 VAL E -10 REMARK 465 LEU E -9 REMARK 465 LEU E -8 REMARK 465 ALA E -7 REMARK 465 ALA E -6 REMARK 465 ALA E -5 REMARK 465 ALA E -4 REMARK 465 HIS E -3 REMARK 465 SER E -2 REMARK 465 ALA E -1 REMARK 465 PHE E 0 REMARK 465 ALA E 1 REMARK 465 ALA E 120A REMARK 465 GLY E 120B REMARK 465 GLY E 120C REMARK 465 GLY E 120D REMARK 465 GLY E 120E REMARK 465 SER E 120F REMARK 465 GLY E 120G REMARK 465 GLY E 120H REMARK 465 GLY E 120I REMARK 465 GLY E 120J REMARK 465 SER E 120K REMARK 465 GLY E 120L REMARK 465 GLY E 120M REMARK 465 GLY E 120N REMARK 465 GLY E 120O REMARK 465 SER E 120P REMARK 465 VAL E 248 REMARK 465 ASP E 249 REMARK 465 GLU E 250 REMARK 465 ASN E 251 REMARK 465 LEU E 252 REMARK 465 TYR E 253 REMARK 465 PHE E 254 REMARK 465 GLN E 255 REMARK 465 GLY E 256 REMARK 465 ALA E 257 REMARK 465 SER E 258 REMARK 465 HIS E 259 REMARK 465 HIS E 260 REMARK 465 HIS E 261 REMARK 465 HIS E 262 REMARK 465 HIS E 263 REMARK 465 HIS E 264 REMARK 465 HIS E 265 REMARK 465 HIS E 266 REMARK 465 MET G 1 REMARK 465 ALA G 2 REMARK 465 SER G 3 REMARK 465 ASN G 4 REMARK 465 ASN G 5 REMARK 465 THR G 6 REMARK 465 ALA G 7 REMARK 465 GLU G 63 REMARK 465 LYS G 64 REMARK 465 LYS G 65 REMARK 465 PHE G 66 REMARK 465 PHE G 67 REMARK 465 CYS G 68 REMARK 465 ALA G 69 REMARK 465 ILE G 70 REMARK 465 LEU G 71 REMARK 465 ASP A 1 REMARK 465 MET A 2 REMARK 465 MET C 1 REMARK 465 GLY C 2 REMARK 465 CYS C 3 REMARK 465 THR C 4 REMARK 465 LEU C 5 REMARK 465 SER C 6 REMARK 465 ILE C 55 REMARK 465 TYR C 56 REMARK 465 HIS C 57 REMARK 465 VAL C 58 REMARK 465 ASN C 59 REMARK 465 GLY C 60 REMARK 465 TYR C 61 REMARK 465 SER C 62 REMARK 465 GLU C 63 REMARK 465 GLU C 64 REMARK 465 GLU C 65 REMARK 465 CYS C 66 REMARK 465 LYS C 67 REMARK 465 GLN C 68 REMARK 465 TYR C 69 REMARK 465 LYS C 70 REMARK 465 ALA C 71 REMARK 465 VAL C 72 REMARK 465 VAL C 73 REMARK 465 TYR C 74 REMARK 465 SER C 75 REMARK 465 ASN C 76 REMARK 465 THR C 77 REMARK 465 ILE C 78 REMARK 465 GLN C 79 REMARK 465 SER C 80 REMARK 465 ILE C 81 REMARK 465 ILE C 82 REMARK 465 ALA C 83 REMARK 465 ILE C 84 REMARK 465 ILE C 85 REMARK 465 ARG C 86 REMARK 465 ALA C 87 REMARK 465 MET C 88 REMARK 465 GLY C 89 REMARK 465 ARG C 90 REMARK 465 LEU C 91 REMARK 465 LYS C 92 REMARK 465 ILE C 93 REMARK 465 ASP C 94 REMARK 465 PHE C 95 REMARK 465 GLY C 96 REMARK 465 ASP C 97 REMARK 465 SER C 98 REMARK 465 ALA C 99 REMARK 465 ARG C 100 REMARK 465 ALA C 101 REMARK 465 ASP C 102 REMARK 465 ASP C 103 REMARK 465 ALA C 104 REMARK 465 ARG C 105 REMARK 465 GLN C 106 REMARK 465 LEU C 107 REMARK 465 PHE C 108 REMARK 465 VAL C 109 REMARK 465 LEU C 110 REMARK 465 ALA C 111 REMARK 465 GLY C 112 REMARK 465 ALA C 113 REMARK 465 ALA C 114 REMARK 465 GLU C 115 REMARK 465 GLU C 116 REMARK 465 GLY C 117 REMARK 465 PHE C 118 REMARK 465 MET C 119 REMARK 465 THR C 120 REMARK 465 ALA C 121 REMARK 465 GLU C 122 REMARK 465 LEU C 123 REMARK 465 ALA C 124 REMARK 465 GLY C 125 REMARK 465 VAL C 126 REMARK 465 ILE C 127 REMARK 465 LYS C 128 REMARK 465 ARG C 129 REMARK 465 LEU C 130 REMARK 465 TRP C 131 REMARK 465 LYS C 132 REMARK 465 ASP C 133 REMARK 465 SER C 134 REMARK 465 GLY C 135 REMARK 465 VAL C 136 REMARK 465 GLN C 137 REMARK 465 ALA C 138 REMARK 465 CYS C 139 REMARK 465 PHE C 140 REMARK 465 ASN C 141 REMARK 465 ARG C 142 REMARK 465 SER C 143 REMARK 465 ARG C 144 REMARK 465 GLU C 145 REMARK 465 TYR C 146 REMARK 465 GLN C 147 REMARK 465 LEU C 148 REMARK 465 ASN C 149 REMARK 465 ASP C 150 REMARK 465 SER C 151 REMARK 465 ALA C 152 REMARK 465 ALA C 153 REMARK 465 TYR C 154 REMARK 465 TYR C 155 REMARK 465 LEU C 156 REMARK 465 ASN C 157 REMARK 465 ASP C 158 REMARK 465 LEU C 159 REMARK 465 ASP C 160 REMARK 465 ARG C 161 REMARK 465 ILE C 162 REMARK 465 ALA C 163 REMARK 465 GLN C 164 REMARK 465 PRO C 165 REMARK 465 ASN C 166 REMARK 465 TYR C 167 REMARK 465 ILE C 168 REMARK 465 PRO C 169 REMARK 465 THR C 170 REMARK 465 GLN C 171 REMARK 465 GLN C 172 REMARK 465 ASP C 173 REMARK 465 VAL C 174 REMARK 465 LEU C 175 REMARK 465 ARG C 176 REMARK 465 THR C 177 REMARK 465 ARG C 178 REMARK 465 VAL C 179 REMARK 465 LYS C 180 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 GLN B 80 CG CD OE1 NE2 REMARK 470 TRP B 83 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP B 83 CZ3 CH2 REMARK 470 ARG B 84 CG CD NE CZ NH1 NH2 REMARK 470 LEU B 87 CG CD1 CD2 REMARK 470 SER B 89 OG REMARK 470 LEU B 90 CG CD1 CD2 REMARK 470 TRP B 108 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP B 108 CZ3 CH2 REMARK 470 LYS B 114 CG CD CE NZ REMARK 470 MET B 116 CG SD CE REMARK 470 ARG B 117 CG CD NE CZ NH1 NH2 REMARK 470 PHE B 129 CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE B 137 CG CD1 CD2 CE1 CE2 CZ REMARK 470 HIS B 148 CG ND1 CD2 CE1 NE2 REMARK 470 GLU B 150 CG CD OE1 OE2 REMARK 470 TYR B 152 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ASN B 156 CG OD1 ND2 REMARK 470 TYR B 157 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ARG B 159 CG CD NE CZ NH1 NH2 REMARK 470 LYS B 192 CG CD CE NZ REMARK 470 ARG B 194 CG CD NE CZ NH1 NH2 REMARK 470 THR B 198 OG1 CG2 REMARK 470 LYS B 201 CG CD CE NZ REMARK 470 PHE B 216 CG CD1 CD2 CE1 CE2 CZ REMARK 470 LYS B 225 CG CD CE NZ REMARK 470 MET B 227 CG SD CE REMARK 470 ARG B 230 CG CD NE CZ NH1 NH2 REMARK 470 LEU B 232 CG CD1 CD2 REMARK 470 PHE B 234 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLU B 239 CG CD OE1 OE2 REMARK 470 LYS B 242 CG CD CE NZ REMARK 470 GLN B 243 CG CD OE1 NE2 REMARK 470 GLN B 326 CG CD OE1 NE2 REMARK 470 GLN B 327 CG CD OE1 NE2 REMARK 470 ARG B 330 CG CD NE CZ NH1 NH2 REMARK 470 TRP B 331 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP B 331 CZ3 CH2 REMARK 470 LYS B 332 CG CD CE NZ REMARK 470 TYR B 333 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LEU B 339 CG CD1 CD2 REMARK 470 LYS B 361 CG CD CE NZ REMARK 470 ARG B 362 CG CD NE CZ NH1 NH2 REMARK 470 PHE B 367 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLU D 3 CG CD OE1 OE2 REMARK 470 LEU D 4 CG CD1 CD2 REMARK 470 ASP D 5 CG OD1 OD2 REMARK 470 GLN D 6 CG CD OE1 NE2 REMARK 470 ARG D 8 CG CD NE CZ NH1 NH2 REMARK 470 GLN D 9 CG CD OE1 NE2 REMARK 470 LYS D 15 CG CD CE NZ REMARK 470 ASN D 36 CG OD1 ND2 REMARK 470 ARG D 42 CG CD NE CZ NH1 NH2 REMARK 470 ARG D 129 CG CD NE CZ NH1 NH2 REMARK 470 GLU D 130 CG CD OE1 OE2 REMARK 470 GLU D 215 CG CD OE1 OE2 REMARK 470 ARG G 62 CG CD NE CZ NH1 NH2 REMARK 470 HIS A 3 CG ND1 CD2 CE1 NE2 REMARK 470 GLU C 289 CG CD OE1 OE2 REMARK 470 ASP C 290 CG OD1 OD2 REMARK 470 THR C 292 OG1 CG2 REMARK 470 GLU C 294 CG CD OE1 OE2 REMARK 470 LYS C 310 CG CD CE NZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG SER D 245 OD1 ASP D 247 2.11 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLN B 80 151.56 -45.51 REMARK 500 SER B 149 69.16 -69.91 REMARK 500 SER B 222 40.48 -99.03 REMARK 500 TRP B 331 47.52 -91.85 REMARK 500 LYS B 332 -5.54 65.04 REMARK 500 TYR B 333 -0.98 -140.49 REMARK 500 ASN D 36 51.67 -92.92 REMARK 500 THR D 87 18.55 59.74 REMARK 500 PRO E 14 1.87 -64.33 REMARK 500 GLU E 42 27.37 46.62 REMARK 500 VAL E 48 -61.01 -104.99 REMARK 500 MET E 192 -6.86 72.83 REMARK 500 SER E 193 -2.96 -143.93 REMARK 500 GLU G 47 32.91 -96.66 REMARK 500 LEU A 9 63.15 62.39 REMARK 500 ASP C 217 41.88 36.28 REMARK 500 PRO C 288 -176.81 -68.80 REMARK 500 THR C 292 73.12 53.49 REMARK 500 PRO C 293 49.55 -79.48 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-36145 RELATED DB: EMDB REMARK 900 SUBSTANCE P BOUND TO ACTIVE HUMAN NEUROKININ 3 RECEPTOR IN COMPLEX REMARK 900 WITH GQ DBREF 8JBG B -121 1306 PDB 8JBG 8JBG -121 1306 DBREF 8JBG D 2 340 UNP P54311 GBB1_RAT 2 340 DBREF 8JBG E -36 266 PDB 8JBG 8JBG -36 266 DBREF 8JBG G 1 71 UNP P63212 GBG2_BOVIN 1 71 DBREF 8JBG A 1 10 UNP Q9UHF0 TKNK_HUMAN 81 90 DBREF 8JBG C 1 361 PDB 8JBG 8JBG 1 361 SEQADV 8JBG HIS D -10 UNP P54311 EXPRESSION TAG SEQADV 8JBG MET D -9 UNP P54311 EXPRESSION TAG SEQADV 8JBG HIS D -8 UNP P54311 EXPRESSION TAG SEQADV 8JBG HIS D -7 UNP P54311 EXPRESSION TAG SEQADV 8JBG HIS D -6 UNP P54311 EXPRESSION TAG SEQADV 8JBG HIS D -5 UNP P54311 EXPRESSION TAG SEQADV 8JBG HIS D -4 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D -3 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D -2 UNP P54311 EXPRESSION TAG SEQADV 8JBG LEU D -1 UNP P54311 EXPRESSION TAG SEQADV 8JBG LEU D 0 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLN D 1 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 341 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D 342 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D 343 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 344 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 345 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 346 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 347 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D 348 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 349 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 350 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 351 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 352 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D 353 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D 354 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 355 UNP P54311 EXPRESSION TAG SEQADV 8JBG VAL D 356 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D 357 UNP P54311 EXPRESSION TAG SEQADV 8JBG GLY D 358 UNP P54311 EXPRESSION TAG SEQADV 8JBG TRP D 359 UNP P54311 EXPRESSION TAG SEQADV 8JBG ARG D 360 UNP P54311 EXPRESSION TAG SEQADV 8JBG LEU D 361 UNP P54311 EXPRESSION TAG SEQADV 8JBG PHE D 362 UNP P54311 EXPRESSION TAG SEQADV 8JBG LYS D 363 UNP P54311 EXPRESSION TAG SEQADV 8JBG LYS D 364 UNP P54311 EXPRESSION TAG SEQADV 8JBG ILE D 365 UNP P54311 EXPRESSION TAG SEQADV 8JBG SER D 366 UNP P54311 EXPRESSION TAG SEQRES 1 B 1428 MET LYS THR ILE ILE ALA LEU SER TYR ILE PHE CYS LEU SEQRES 2 B 1428 VAL PHE ALA ALA ASP LEU GLU ASP ASN TRP GLU THR LEU SEQRES 3 B 1428 ASN ASP ASN LEU LYS VAL ILE GLU LYS ALA ASP ASN ALA SEQRES 4 B 1428 ALA GLN VAL LYS ASP ALA LEU THR LYS MET ARG ALA ALA SEQRES 5 B 1428 ALA LEU ASP ALA GLN LYS ALA THR PRO PRO LYS LEU GLU SEQRES 6 B 1428 ASP LYS SER PRO ASP SER PRO GLU MET LYS ASP PHE ARG SEQRES 7 B 1428 HIS GLY PHE ASP ILE LEU VAL GLY GLN ILE ASP ASP ALA SEQRES 8 B 1428 LEU LYS LEU ALA ASN GLU GLY LYS VAL LYS GLU ALA GLN SEQRES 9 B 1428 ALA ALA ALA GLU GLN LEU LYS THR THR ARG ASN ALA TYR SEQRES 10 B 1428 ILE GLN LYS TYR LEU MET ALA THR LEU PRO ALA ALA GLU SEQRES 11 B 1428 THR TRP ILE ASP GLY GLY GLY GLY VAL GLY ALA ASP ALA SEQRES 12 B 1428 VAL ASN LEU THR ALA SER LEU ALA ALA GLY ALA ALA THR SEQRES 13 B 1428 GLY ALA VAL GLU THR GLY TRP LEU GLN LEU LEU ASP GLN SEQRES 14 B 1428 ALA GLY ASN LEU SER SER SER PRO SER ALA LEU GLY LEU SEQRES 15 B 1428 PRO VAL ALA SER PRO ALA PRO SER GLN PRO TRP ALA ASN SEQRES 16 B 1428 LEU THR ASN GLN PHE VAL GLN PRO SER TRP ARG ILE ALA SEQRES 17 B 1428 LEU TRP SER LEU ALA TYR GLY VAL VAL VAL ALA VAL ALA SEQRES 18 B 1428 VAL LEU GLY ASN LEU ILE VAL ILE TRP ILE ILE LEU ALA SEQRES 19 B 1428 HIS LYS ARG MET ARG THR VAL THR ASN TYR PHE LEU VAL SEQRES 20 B 1428 ASN LEU ALA PHE SER ASP ALA SER MET ALA ALA PHE ASN SEQRES 21 B 1428 THR LEU VAL ASN PHE ILE TYR ALA LEU HIS SER GLU TRP SEQRES 22 B 1428 TYR PHE GLY ALA ASN TYR CYS ARG PHE GLN ASN PHE PHE SEQRES 23 B 1428 PRO ILE THR ALA VAL PHE ALA SER ILE TYR SER MET THR SEQRES 24 B 1428 ALA ILE ALA VAL ASP ARG TYR MET ALA ILE ILE ASP PRO SEQRES 25 B 1428 LEU LYS PRO ARG LEU SER ALA THR ALA THR LYS ILE VAL SEQRES 26 B 1428 ILE GLY SER ILE TRP ILE LEU ALA PHE LEU LEU ALA PHE SEQRES 27 B 1428 PRO GLN CYS LEU TYR SER LYS THR LYS VAL MET PRO GLY SEQRES 28 B 1428 ARG THR LEU CYS PHE VAL GLN TRP PRO GLU GLY PRO LYS SEQRES 29 B 1428 GLN HIS PHE THR TYR HIS ILE ILE VAL ILE ILE LEU VAL SEQRES 30 B 1428 TYR CYS PHE PRO LEU LEU ILE MET GLY ILE THR TYR THR SEQRES 31 B 1428 ILE VAL GLY ILE THR LEU TRP GLY GLY GLU ILE PRO GLY SEQRES 32 B 1428 ASP THR CYS ASP LYS TYR HIS GLU GLN LEU LYS ALA LYS SEQRES 33 B 1428 ARG LYS VAL VAL LYS MET MET ILE ILE VAL VAL MET THR SEQRES 34 B 1428 PHE ALA ILE CYS TRP LEU PRO TYR HIS ILE TYR PHE ILE SEQRES 35 B 1428 LEU THR ALA ILE TYR GLN GLN LEU ASN ARG TRP LYS TYR SEQRES 36 B 1428 ILE GLN GLN VAL TYR LEU ALA SER PHE TRP LEU ALA MET SEQRES 37 B 1428 SER SER THR MET TYR ASN PRO ILE ILE TYR CYS CYS LEU SEQRES 38 B 1428 ASN LYS ARG PHE ARG ALA GLY PHE LYS ARG ALA PHE ARG SEQRES 39 B 1428 TRP CYS PRO PHE ILE LYS VAL SER SER TYR ASP GLU LEU SEQRES 40 B 1428 GLU LEU LYS THR THR ARG PHE HIS PRO VAL PHE THR LEU SEQRES 41 B 1428 GLU ASP PHE VAL GLY ASP TRP GLU GLN THR ALA ALA TYR SEQRES 42 B 1428 ASN LEU ASP GLN VAL LEU GLU GLN GLY GLY VAL SER SER SEQRES 43 B 1428 LEU LEU GLN ASN LEU ALA VAL SER VAL THR PRO ILE GLN SEQRES 44 B 1428 ARG ILE VAL ARG SER GLY GLU ASN ALA LEU LYS ILE ASP SEQRES 45 B 1428 ILE HIS VAL ILE ILE PRO TYR GLU GLY LEU SER ALA ASP SEQRES 46 B 1428 GLN MET ALA GLN ILE GLU GLU VAL PHE LYS VAL VAL TYR SEQRES 47 B 1428 PRO VAL ASP ASP HIS HIS PHE LYS VAL ILE LEU PRO TYR SEQRES 48 B 1428 GLY THR LEU VAL ILE ASP GLY VAL THR PRO ASN MET LEU SEQRES 49 B 1428 ASN TYR PHE GLY ARG PRO TYR GLU GLY ILE ALA VAL PHE SEQRES 50 B 1428 ASP GLY LYS LYS ILE THR VAL THR GLY THR LEU TRP ASN SEQRES 51 B 1428 GLY ASN LYS ILE ILE ASP GLU ARG LEU ILE THR PRO ASP SEQRES 52 B 1428 GLY SER MET LEU PHE ARG VAL THR ILE ASN SER GLY GLY SEQRES 53 B 1428 SER GLU ASN LEU TYR PHE GLN GLY GLY SER ALA GLY SER SEQRES 54 B 1428 ALA ALA LYS ILE GLU GLU GLY LYS LEU VAL ILE TRP ILE SEQRES 55 B 1428 ASN GLY ASP LYS GLY TYR ASN GLY LEU ALA GLU VAL GLY SEQRES 56 B 1428 LYS LYS PHE GLU LYS ASP THR GLY ILE LYS VAL THR VAL SEQRES 57 B 1428 GLU HIS PRO ASP LYS LEU GLU GLU LYS PHE PRO GLN VAL SEQRES 58 B 1428 ALA ALA THR GLY ASP GLY PRO ASP ILE ILE PHE TRP ALA SEQRES 59 B 1428 HIS ASP ARG PHE GLY GLY TYR ALA GLN SER GLY LEU LEU SEQRES 60 B 1428 ALA GLU ILE THR PRO ASP LYS ALA PHE GLN ASP LYS LEU SEQRES 61 B 1428 TYR PRO PHE THR TRP ASP ALA VAL ARG TYR ASN GLY LYS SEQRES 62 B 1428 LEU ILE ALA TYR PRO ILE ALA VAL GLU ALA LEU SER LEU SEQRES 63 B 1428 ILE TYR ASN LYS ASP LEU LEU PRO ASN PRO PRO LYS THR SEQRES 64 B 1428 TRP GLU GLU ILE PRO ALA LEU ASP LYS GLU LEU LYS ALA SEQRES 65 B 1428 LYS GLY LYS SER ALA LEU MET PHE ASN LEU GLN GLU PRO SEQRES 66 B 1428 TYR PHE THR TRP PRO LEU ILE ALA ALA ASP GLY GLY TYR SEQRES 67 B 1428 ALA PHE LYS TYR GLU ASN GLY LYS TYR ASP ILE LYS ASP SEQRES 68 B 1428 VAL GLY VAL ASP ASN ALA GLY ALA LYS ALA GLY LEU THR SEQRES 69 B 1428 PHE LEU VAL ASP LEU ILE LYS ASN LYS HIS MET ASN ALA SEQRES 70 B 1428 ASP THR ASP TYR SER ILE ALA GLU ALA ALA PHE ASN LYS SEQRES 71 B 1428 GLY GLU THR ALA MET THR ILE ASN GLY PRO TRP ALA TRP SEQRES 72 B 1428 SER ASN ILE ASP THR SER LYS VAL ASN TYR GLY VAL THR SEQRES 73 B 1428 VAL LEU PRO THR PHE LYS GLY GLN PRO SER LYS PRO PHE SEQRES 74 B 1428 VAL GLY VAL LEU SER ALA GLY ILE ASN ALA ALA SER PRO SEQRES 75 B 1428 ASN LYS GLU LEU ALA LYS GLU PHE LEU GLU ASN TYR LEU SEQRES 76 B 1428 LEU THR ASP GLU GLY LEU GLU ALA VAL ASN LYS ASP LYS SEQRES 77 B 1428 PRO LEU GLY ALA VAL ALA LEU LYS SER TYR GLU GLU GLU SEQRES 78 B 1428 LEU ALA LYS ASP PRO ARG ILE ALA ALA THR MET GLU ASN SEQRES 79 B 1428 ALA GLN LYS GLY GLU ILE MET PRO ASN ILE PRO GLN MET SEQRES 80 B 1428 SER ALA PHE TRP TYR ALA VAL ARG THR ALA VAL ILE ASN SEQRES 81 B 1428 ALA ALA SER GLY ARG GLN THR VAL ASP GLU ALA LEU LYS SEQRES 82 B 1428 ASP ALA GLN THR ALA LYS ILE GLU GLU GLY LYS LEU VAL SEQRES 83 B 1428 ILE TRP ILE ASN GLY ASP LYS GLY TYR ASN GLY LEU ALA SEQRES 84 B 1428 GLU VAL GLY LYS LYS PHE GLU LYS ASP THR GLY ILE LYS SEQRES 85 B 1428 VAL THR VAL GLU HIS PRO ASP LYS LEU GLU GLU LYS PHE SEQRES 86 B 1428 PRO GLN VAL ALA ALA THR GLY ASP GLY PRO ASP ILE ILE SEQRES 87 B 1428 PHE TRP ALA HIS ASP ARG PHE GLY GLY TYR ALA GLN SER SEQRES 88 B 1428 GLY LEU LEU ALA GLU ILE THR PRO ASP LYS ALA PHE GLN SEQRES 89 B 1428 ASP LYS LEU TYR PRO PHE THR TRP ASP ALA VAL ARG TYR SEQRES 90 B 1428 ASN GLY LYS LEU ILE ALA TYR PRO ILE ALA VAL GLU ALA SEQRES 91 B 1428 LEU SER LEU ILE TYR ASN LYS ASP LEU LEU PRO ASN PRO SEQRES 92 B 1428 PRO LYS THR TRP GLU GLU ILE PRO ALA LEU ASP LYS GLU SEQRES 93 B 1428 LEU LYS ALA LYS GLY LYS SER ALA LEU MET PHE ASN LEU SEQRES 94 B 1428 GLN GLU PRO TYR PHE THR TRP PRO LEU ILE ALA ALA ASP SEQRES 95 B 1428 GLY GLY TYR ALA PHE LYS TYR GLU ASN GLY LYS TYR ASP SEQRES 96 B 1428 ILE LYS ASP VAL GLY VAL ASP ASN ALA GLY ALA LYS ALA SEQRES 97 B 1428 GLY LEU THR PHE LEU VAL ASP LEU ILE LYS ASN LYS HIS SEQRES 98 B 1428 MET ASN ALA ASP THR ASP TYR SER ILE ALA GLU ALA ALA SEQRES 99 B 1428 PHE ASN LYS GLY GLU THR ALA MET THR ILE ASN GLY PRO SEQRES 100 B 1428 TRP ALA TRP SER ASN ILE ASP THR SER LYS VAL ASN TYR SEQRES 101 B 1428 GLY VAL THR VAL LEU PRO THR PHE LYS GLY GLN PRO SER SEQRES 102 B 1428 LYS PRO PHE VAL GLY VAL LEU SER ALA GLY ILE ASN ALA SEQRES 103 B 1428 ALA SER PRO ASN LYS GLU LEU ALA LYS GLU PHE LEU GLU SEQRES 104 B 1428 ASN TYR LEU LEU THR ASP GLU GLY LEU GLU ALA VAL ASN SEQRES 105 B 1428 LYS ASP LYS PRO LEU GLY ALA VAL ALA LEU LYS SER TYR SEQRES 106 B 1428 GLU GLU GLU LEU ALA LYS ASP PRO ARG ILE ALA ALA THR SEQRES 107 B 1428 MET GLU ASN ALA GLN LYS GLY GLU ILE MET PRO ASN ILE SEQRES 108 B 1428 PRO GLN MET SER ALA PHE TRP TYR ALA VAL ARG THR ALA SEQRES 109 B 1428 VAL ILE ASN ALA ALA SER GLY ARG GLN THR VAL ASP GLU SEQRES 110 B 1428 ALA LEU LYS ASP ALA GLN THR ARG ILE THR LYS SEQRES 1 D 377 HIS MET HIS HIS HIS HIS HIS GLY SER LEU LEU GLN SER SEQRES 2 D 377 GLU LEU ASP GLN LEU ARG GLN GLU ALA GLU GLN LEU LYS SEQRES 3 D 377 ASN GLN ILE ARG ASP ALA ARG LYS ALA CYS ALA ASP ALA SEQRES 4 D 377 THR LEU SER GLN ILE THR ASN ASN ILE ASP PRO VAL GLY SEQRES 5 D 377 ARG ILE GLN MET ARG THR ARG ARG THR LEU ARG GLY HIS SEQRES 6 D 377 LEU ALA LYS ILE TYR ALA MET HIS TRP GLY THR ASP SER SEQRES 7 D 377 ARG LEU LEU VAL SER ALA SER GLN ASP GLY LYS LEU ILE SEQRES 8 D 377 ILE TRP ASP SER TYR THR THR ASN LYS VAL HIS ALA ILE SEQRES 9 D 377 PRO LEU ARG SER SER TRP VAL MET THR CYS ALA TYR ALA SEQRES 10 D 377 PRO SER GLY ASN TYR VAL ALA CYS GLY GLY LEU ASP ASN SEQRES 11 D 377 ILE CYS SER ILE TYR ASN LEU LYS THR ARG GLU GLY ASN SEQRES 12 D 377 VAL ARG VAL SER ARG GLU LEU ALA GLY HIS THR GLY TYR SEQRES 13 D 377 LEU SER CYS CYS ARG PHE LEU ASP ASP ASN GLN ILE VAL SEQRES 14 D 377 THR SER SER GLY ASP THR THR CYS ALA LEU TRP ASP ILE SEQRES 15 D 377 GLU THR GLY GLN GLN THR THR THR PHE THR GLY HIS THR SEQRES 16 D 377 GLY ASP VAL MET SER LEU SER LEU ALA PRO ASP THR ARG SEQRES 17 D 377 LEU PHE VAL SER GLY ALA CYS ASP ALA SER ALA LYS LEU SEQRES 18 D 377 TRP ASP VAL ARG GLU GLY MET CYS ARG GLN THR PHE THR SEQRES 19 D 377 GLY HIS GLU SER ASP ILE ASN ALA ILE CYS PHE PHE PRO SEQRES 20 D 377 ASN GLY ASN ALA PHE ALA THR GLY SER ASP ASP ALA THR SEQRES 21 D 377 CYS ARG LEU PHE ASP LEU ARG ALA ASP GLN GLU LEU MET SEQRES 22 D 377 THR TYR SER HIS ASP ASN ILE ILE CYS GLY ILE THR SER SEQRES 23 D 377 VAL SER PHE SER LYS SER GLY ARG LEU LEU LEU ALA GLY SEQRES 24 D 377 TYR ASP ASP PHE ASN CYS ASN VAL TRP ASP ALA LEU LYS SEQRES 25 D 377 ALA ASP ARG ALA GLY VAL LEU ALA GLY HIS ASP ASN ARG SEQRES 26 D 377 VAL SER CYS LEU GLY VAL THR ASP ASP GLY MET ALA VAL SEQRES 27 D 377 ALA THR GLY SER TRP ASP SER PHE LEU LYS ILE TRP ASN SEQRES 28 D 377 GLY SER SER GLY GLY GLY GLY SER GLY GLY GLY GLY SER SEQRES 29 D 377 SER GLY VAL SER GLY TRP ARG LEU PHE LYS LYS ILE SER SEQRES 1 E 304 MET LEU LEU VAL ASN GLN SER HIS GLN GLY PHE ASN LYS SEQRES 2 E 304 GLU HIS THR SER LYS MET VAL SER ALA ILE VAL LEU TYR SEQRES 3 E 304 VAL LEU LEU ALA ALA ALA ALA HIS SER ALA PHE ALA VAL SEQRES 4 E 304 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN PRO GLY SEQRES 5 E 304 GLY SER ARG LYS LEU SER CYS SER ALA SER GLY PHE ALA SEQRES 6 E 304 PHE SER SER PHE GLY MET HIS TRP VAL ARG GLN ALA PRO SEQRES 7 E 304 GLU LYS GLY LEU GLU TRP VAL ALA TYR ILE SER SER GLY SEQRES 8 E 304 SER GLY THR ILE TYR TYR ALA ASP THR VAL LYS GLY ARG SEQRES 9 E 304 PHE THR ILE SER ARG ASP ASP PRO LYS ASN THR LEU PHE SEQRES 10 E 304 LEU GLN MET THR SER LEU ARG SER GLU ASP THR ALA MET SEQRES 11 E 304 TYR TYR CYS VAL ARG SER ILE TYR TYR TYR GLY SER SER SEQRES 12 E 304 PRO PHE ASP PHE TRP GLY GLN GLY THR THR LEU THR VAL SEQRES 13 E 304 SER ALA GLY GLY GLY GLY SER GLY GLY GLY GLY SER GLY SEQRES 14 E 304 GLY GLY GLY SER SER ASP ILE VAL MET THR GLN ALA THR SEQRES 15 E 304 SER SER VAL PRO VAL THR PRO GLY GLU SER VAL SER ILE SEQRES 16 E 304 SER CYS ARG SER SER LYS SER LEU LEU HIS SER ASN GLY SEQRES 17 E 304 ASN THR TYR LEU TYR TRP PHE LEU GLN ARG PRO GLY GLN SEQRES 18 E 304 SER PRO GLN LEU LEU ILE TYR ARG MET SER ASN LEU ALA SEQRES 19 E 304 SER GLY VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY SEQRES 20 E 304 THR ALA PHE THR LEU THR ILE SER ARG LEU GLU ALA GLU SEQRES 21 E 304 ASP VAL GLY VAL TYR TYR CYS MET GLN HIS LEU GLU TYR SEQRES 22 E 304 PRO LEU THR PHE GLY ALA GLY THR LYS LEU GLU LEU VAL SEQRES 23 E 304 ASP GLU ASN LEU TYR PHE GLN GLY ALA SER HIS HIS HIS SEQRES 24 E 304 HIS HIS HIS HIS HIS SEQRES 1 G 71 MET ALA SER ASN ASN THR ALA SER ILE ALA GLN ALA ARG SEQRES 2 G 71 LYS LEU VAL GLU GLN LEU LYS MET GLU ALA ASN ILE ASP SEQRES 3 G 71 ARG ILE LYS VAL SER LYS ALA ALA ALA ASP LEU MET ALA SEQRES 4 G 71 TYR CYS GLU ALA HIS ALA LYS GLU ASP PRO LEU LEU THR SEQRES 5 G 71 PRO VAL PRO ALA SER GLU ASN PRO PHE ARG GLU LYS LYS SEQRES 6 G 71 PHE PHE CYS ALA ILE LEU SEQRES 1 A 10 ASP MET HIS ASP PHE PHE VAL GLY LEU MET SEQRES 1 C 361 MET GLY CYS THR LEU SER ALA GLU ASP LYS ALA ALA VAL SEQRES 2 C 361 GLU ARG SER LYS MET ILE GLU LYS GLN LEU GLN LYS ASP SEQRES 3 C 361 LYS GLN VAL TYR ARG ARG THR LEU ARG LEU LEU LEU LEU SEQRES 4 C 361 GLY ALA ASP ASN SER GLY LYS SER THR ILE VAL LYS GLN SEQRES 5 C 361 MET ARG ILE TYR HIS VAL ASN GLY TYR SER GLU GLU GLU SEQRES 6 C 361 CYS LYS GLN TYR LYS ALA VAL VAL TYR SER ASN THR ILE SEQRES 7 C 361 GLN SER ILE ILE ALA ILE ILE ARG ALA MET GLY ARG LEU SEQRES 8 C 361 LYS ILE ASP PHE GLY ASP SER ALA ARG ALA ASP ASP ALA SEQRES 9 C 361 ARG GLN LEU PHE VAL LEU ALA GLY ALA ALA GLU GLU GLY SEQRES 10 C 361 PHE MET THR ALA GLU LEU ALA GLY VAL ILE LYS ARG LEU SEQRES 11 C 361 TRP LYS ASP SER GLY VAL GLN ALA CYS PHE ASN ARG SER SEQRES 12 C 361 ARG GLU TYR GLN LEU ASN ASP SER ALA ALA TYR TYR LEU SEQRES 13 C 361 ASN ASP LEU ASP ARG ILE ALA GLN PRO ASN TYR ILE PRO SEQRES 14 C 361 THR GLN GLN ASP VAL LEU ARG THR ARG VAL LYS THR SER SEQRES 15 C 361 GLY ILE PHE GLU THR LYS PHE GLN VAL ASP LYS VAL ASN SEQRES 16 C 361 PHE HIS MET PHE ASP VAL GLY ALA GLN ARG ASP GLU ARG SEQRES 17 C 361 ARG LYS TRP ILE GLN CYS PHE ASN ASP VAL THR ALA ILE SEQRES 18 C 361 ILE PHE VAL VAL ASP SER SER ASP TYR ASN ARG LEU GLN SEQRES 19 C 361 GLU ALA LEU ASN ASP PHE ASP SER ILE TRP ASN ASN ARG SEQRES 20 C 361 TRP LEU ARG THR ILE SER VAL ILE LEU PHE LEU ASN LYS SEQRES 21 C 361 GLN ASP LEU LEU ALA GLU LYS VAL LEU ALA GLY LYS SER SEQRES 22 C 361 LYS ILE GLU ASP TYR PHE PRO GLU PHE ALA ARG TYR THR SEQRES 23 C 361 THR PRO GLU ASP ALA THR PRO GLU PRO GLY GLU ASP PRO SEQRES 24 C 361 ARG VAL THR ARG ALA LYS TYR PHE ILE ARG LYS GLU PHE SEQRES 25 C 361 VAL ASP ILE SER THR ALA SER GLY ASP GLY ARG HIS ILE SEQRES 26 C 361 CYS TYR PRO HIS PHE THR CYS ALA VAL ASP THR GLU ASN SEQRES 27 C 361 ALA ARG ARG ILE PHE ASN ASP CYS LYS ASP ILE ILE LEU SEQRES 28 C 361 GLN MET ASN LEU ARG GLU TYR ASN LEU VAL HELIX 1 AA1 PRO B 81 HIS B 113 1 33 HELIX 2 AA2 THR B 118 THR B 120 5 3 HELIX 3 AA3 ASN B 121 PHE B 137 1 17 HELIX 4 AA4 ASN B 138 LEU B 147 1 10 HELIX 5 AA5 GLY B 154 GLN B 161 1 8 HELIX 6 AA6 PHE B 163 ASP B 189 1 27 HELIX 7 AA7 SER B 196 TYR B 221 1 26 HELIX 8 AA8 GLU B 239 TRP B 275 1 37 HELIX 9 AA9 LEU B 291 TYR B 325 1 35 HELIX 10 AB1 GLN B 326 TRP B 331 5 6 HELIX 11 AB2 TYR B 333 SER B 347 1 15 HELIX 12 AB3 SER B 347 ASN B 360 1 14 HELIX 13 AB4 ASN B 360 LYS B 368 1 9 HELIX 14 AB5 LEU D 4 ALA D 26 1 23 HELIX 15 AB6 THR D 29 ASN D 35 1 7 HELIX 16 AB7 ALA E 28 PHE E 32 5 5 HELIX 17 AB8 ARG E 87 THR E 91 5 5 HELIX 18 AB9 GLU E 220 VAL E 224 5 5 HELIX 19 AC1 ILE G 9 ALA G 23 1 15 HELIX 20 AC2 LYS G 29 HIS G 44 1 16 HELIX 21 AC3 GLU C 8 THR C 33 1 26 HELIX 22 AC4 GLY C 45 GLN C 52 1 8 HELIX 23 AC5 LYS C 210 ASN C 216 5 7 HELIX 24 AC6 ARG C 232 ASN C 245 1 14 HELIX 25 AC7 LYS C 260 ALA C 270 1 11 HELIX 26 AC8 LYS C 274 TYR C 278 5 5 HELIX 27 AC9 ASP C 298 SER C 319 1 22 HELIX 28 AD1 GLU C 337 TYR C 358 1 22 SHEET 1 AA1 2 THR B 224 LYS B 225 0 SHEET 2 AA1 2 CYS B 233 PHE B 234 -1 O CYS B 233 N LYS B 225 SHEET 1 AA2 4 ARG D 46 LEU D 51 0 SHEET 2 AA2 4 LEU D 336 ASN D 340 -1 O LEU D 336 N LEU D 51 SHEET 3 AA2 4 VAL D 327 SER D 331 -1 N VAL D 327 O TRP D 339 SHEET 4 AA2 4 VAL D 315 VAL D 320 -1 N GLY D 319 O ALA D 328 SHEET 1 AA3 4 ILE D 58 TRP D 63 0 SHEET 2 AA3 4 LEU D 69 SER D 74 -1 O ALA D 73 N ALA D 60 SHEET 3 AA3 4 LYS D 78 ASP D 83 -1 O TRP D 82 N LEU D 70 SHEET 4 AA3 4 ASN D 88 PRO D 94 -1 O VAL D 90 N ILE D 81 SHEET 1 AA4 4 VAL D 100 TYR D 105 0 SHEET 2 AA4 4 TYR D 111 GLY D 116 -1 O GLY D 115 N MET D 101 SHEET 3 AA4 4 CYS D 121 ASN D 125 -1 O TYR D 124 N VAL D 112 SHEET 4 AA4 4 ARG D 134 LEU D 139 -1 O ARG D 137 N ILE D 123 SHEET 1 AA5 4 LEU D 146 PHE D 151 0 SHEET 2 AA5 4 GLN D 156 SER D 161 -1 O SER D 160 N CYS D 148 SHEET 3 AA5 4 CYS D 166 ASP D 170 -1 O TRP D 169 N ILE D 157 SHEET 4 AA5 4 GLN D 175 PHE D 180 -1 O PHE D 180 N CYS D 166 SHEET 1 AA6 4 VAL D 187 LEU D 192 0 SHEET 2 AA6 4 LEU D 198 ALA D 203 -1 O GLY D 202 N MET D 188 SHEET 3 AA6 4 ALA D 208 ASP D 212 -1 O TRP D 211 N PHE D 199 SHEET 4 AA6 4 CYS D 218 PHE D 222 -1 O PHE D 222 N ALA D 208 SHEET 1 AA7 4 ILE D 229 PHE D 234 0 SHEET 2 AA7 4 ALA D 240 SER D 245 -1 O GLY D 244 N ASN D 230 SHEET 3 AA7 4 CYS D 250 ASP D 254 -1 O PHE D 253 N PHE D 241 SHEET 4 AA7 4 GLN D 259 TYR D 264 -1 O TYR D 264 N CYS D 250 SHEET 1 AA8 4 ILE D 273 PHE D 278 0 SHEET 2 AA8 4 LEU D 284 TYR D 289 -1 O GLY D 288 N SER D 275 SHEET 3 AA8 4 CYS D 294 ASP D 298 -1 O TRP D 297 N LEU D 285 SHEET 4 AA8 4 ARG D 304 LEU D 308 -1 O GLY D 306 N VAL D 296 SHEET 1 AA9 4 GLN E 3 SER E 7 0 SHEET 2 AA9 4 ARG E 18 SER E 25 -1 O SER E 23 N VAL E 5 SHEET 3 AA9 4 THR E 78 MET E 83 -1 O LEU E 81 N LEU E 20 SHEET 4 AA9 4 PHE E 68 ASP E 73 -1 N THR E 69 O GLN E 82 SHEET 1 AB1 6 GLY E 10 VAL E 12 0 SHEET 2 AB1 6 THR E 115 VAL E 119 1 O THR E 118 N VAL E 12 SHEET 3 AB1 6 ALA E 92 SER E 99 -1 N TYR E 94 O THR E 115 SHEET 4 AB1 6 GLY E 33 GLN E 39 -1 N VAL E 37 O TYR E 95 SHEET 5 AB1 6 LEU E 45 ILE E 51 -1 O VAL E 48 N TRP E 36 SHEET 6 AB1 6 ILE E 58 TYR E 60 -1 O TYR E 59 N TYR E 50 SHEET 1 AB2 4 GLY E 10 VAL E 12 0 SHEET 2 AB2 4 THR E 115 VAL E 119 1 O THR E 118 N VAL E 12 SHEET 3 AB2 4 ALA E 92 SER E 99 -1 N TYR E 94 O THR E 115 SHEET 4 AB2 4 PHE E 110 TRP E 111 -1 O PHE E 110 N ARG E 98 SHEET 1 AB3 4 MET E 140 GLN E 142 0 SHEET 2 AB3 4 VAL E 155 SER E 161 -1 O ARG E 160 N THR E 141 SHEET 3 AB3 4 ALA E 211 ILE E 216 -1 O LEU E 214 N ILE E 157 SHEET 4 AB3 4 PHE E 203 GLY E 207 -1 N SER E 206 O THR E 213 SHEET 1 AB4 6 SER E 146 PRO E 148 0 SHEET 2 AB4 6 THR E 243 GLU E 246 1 O LYS E 244 N VAL E 147 SHEET 3 AB4 6 VAL E 226 GLN E 231 -1 N TYR E 227 O THR E 243 SHEET 4 AB4 6 LEU E 174 GLN E 179 -1 N TYR E 175 O MET E 230 SHEET 5 AB4 6 PRO E 185 TYR E 190 -1 O ILE E 189 N TRP E 176 SHEET 6 AB4 6 ASN E 194 LEU E 195 -1 O ASN E 194 N TYR E 190 SHEET 1 AB5 5 ILE C 184 GLN C 190 0 SHEET 2 AB5 5 ASN C 195 VAL C 201 -1 O MET C 198 N THR C 187 SHEET 3 AB5 5 LEU C 34 GLY C 40 1 N LEU C 36 O HIS C 197 SHEET 4 AB5 5 ALA C 220 ASP C 226 1 O ILE C 222 N LEU C 39 SHEET 5 AB5 5 SER C 253 ASN C 259 1 O PHE C 257 N PHE C 223 CISPEP 1 TYR E 235 PRO E 236 0 1.87 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000