HEADER VIRAL PROTEIN/IMMUNE SYSTEM 15-AUG-23 8KFA TITLE CRYO-EM STRUCTURE OF HSV-1 GB WITH D48 FAB COMPLEX COMPND MOL_ID: 1; COMPND 2 MOLECULE: D48 HEAVY CHAIN; COMPND 3 CHAIN: H, D, E; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: D48 LIGHT CHAIN; COMPND 7 CHAIN: L, F, G; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: ENVELOPE GLYCOPROTEIN B; COMPND 11 CHAIN: A, B, C; COMPND 12 SYNONYM: GB; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HUMAN HERPESVIRUS 1 (STRAIN KOS); SOURCE 17 ORGANISM_TAXID: 10306; SOURCE 18 GENE: GB, UL27; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS HSV-1 GB, FAB, NEUTRALIZING ANTIBODY, COMPLEX, CRYO-EM, VIRAL KEYWDS 2 PROTEIN/IMMUNE SYSTEM, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR J.YANG,C.SUN,X.FANG,M.ZENG,Z.LIU JRNL AUTH C.SUN,J.W.YANG,C.XIE,X.Y.FANG,G.L.BU,G.X.ZHAO,D.L.DAI,Z.LIU, JRNL AUTH 2 M.S.ZENG JRNL TITL THE STRUCTURE OF HSV-1 GB BOUND TO A POTENT NEUTRALIZING JRNL TITL 2 ANTIBODY REVEALS A CONSERVATIVE ANTIGENIC DOMAIN ACROSS JRNL TITL 3 HERPESVIRUSES JRNL REF HLIFE 2023 JRNL DOI 10.1016/J.HLIFE.2023.12.004 REMARK 2 REMARK 2 RESOLUTION. 3.04 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.040 REMARK 3 NUMBER OF PARTICLES : 168888 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8KFA COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC. REMARK 100 THE DEPOSITION ID IS D_1300040211. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF HSV-1 GB REMARK 245 WITH D48 FAB COMPLEX REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1200.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 1.56 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, A, D, F, B, E, G, C REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA H 125 REMARK 465 SER H 126 REMARK 465 THR H 127 REMARK 465 LYS H 128 REMARK 465 GLY H 129 REMARK 465 PRO H 130 REMARK 465 SER H 131 REMARK 465 VAL H 132 REMARK 465 PHE H 133 REMARK 465 PRO H 134 REMARK 465 LEU H 135 REMARK 465 ALA H 136 REMARK 465 PRO H 137 REMARK 465 SER H 138 REMARK 465 SER H 139 REMARK 465 LYS H 140 REMARK 465 SER H 141 REMARK 465 THR H 142 REMARK 465 SER H 143 REMARK 465 GLY H 144 REMARK 465 GLY H 145 REMARK 465 THR H 146 REMARK 465 ALA H 147 REMARK 465 ALA H 148 REMARK 465 LEU H 149 REMARK 465 GLY H 150 REMARK 465 CYS H 151 REMARK 465 LEU H 152 REMARK 465 VAL H 153 REMARK 465 LYS H 154 REMARK 465 ASP H 155 REMARK 465 TYR H 156 REMARK 465 PHE H 157 REMARK 465 PRO H 158 REMARK 465 GLU H 159 REMARK 465 PRO H 160 REMARK 465 VAL H 161 REMARK 465 THR H 162 REMARK 465 VAL H 163 REMARK 465 SER H 164 REMARK 465 TRP H 165 REMARK 465 ASN H 166 REMARK 465 SER H 167 REMARK 465 GLY H 168 REMARK 465 ALA H 169 REMARK 465 LEU H 170 REMARK 465 THR H 171 REMARK 465 SER H 172 REMARK 465 GLY H 173 REMARK 465 VAL H 174 REMARK 465 HIS H 175 REMARK 465 THR H 176 REMARK 465 PHE H 177 REMARK 465 PRO H 178 REMARK 465 ALA H 179 REMARK 465 VAL H 180 REMARK 465 LEU H 181 REMARK 465 GLN H 182 REMARK 465 SER H 183 REMARK 465 SER H 184 REMARK 465 GLY H 185 REMARK 465 LEU H 186 REMARK 465 TYR H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 SER H 190 REMARK 465 SER H 191 REMARK 465 VAL H 192 REMARK 465 VAL H 193 REMARK 465 THR H 194 REMARK 465 VAL H 195 REMARK 465 PRO H 196 REMARK 465 SER H 197 REMARK 465 SER H 198 REMARK 465 SER H 199 REMARK 465 LEU H 200 REMARK 465 GLY H 201 REMARK 465 THR H 202 REMARK 465 GLN H 203 REMARK 465 THR H 204 REMARK 465 TYR H 205 REMARK 465 ILE H 206 REMARK 465 CYS H 207 REMARK 465 ASN H 208 REMARK 465 VAL H 209 REMARK 465 ASN H 210 REMARK 465 HIS H 211 REMARK 465 LYS H 212 REMARK 465 PRO H 213 REMARK 465 SER H 214 REMARK 465 ASN H 215 REMARK 465 THR H 216 REMARK 465 LYS H 217 REMARK 465 VAL H 218 REMARK 465 ASP H 219 REMARK 465 LYS H 220 REMARK 465 ARG H 221 REMARK 465 VAL H 222 REMARK 465 GLY H 223 REMARK 465 SER H 224 REMARK 465 HIS H 225 REMARK 465 HIS H 226 REMARK 465 HIS H 227 REMARK 465 HIS H 228 REMARK 465 HIS H 229 REMARK 465 HIS H 230 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 THR A 331 REMARK 465 THR A 332 REMARK 465 LYS A 333 REMARK 465 ALA A 334 REMARK 465 ARG A 335 REMARK 465 ALA A 336 REMARK 465 THR A 337 REMARK 465 LEU A 460 REMARK 465 ALA A 461 REMARK 465 GLU A 462 REMARK 465 LEU A 463 REMARK 465 TYR A 464 REMARK 465 VAL A 465 REMARK 465 ARG A 466 REMARK 465 GLU A 467 REMARK 465 HIS A 468 REMARK 465 LEU A 469 REMARK 465 ARG A 470 REMARK 465 GLU A 471 REMARK 465 GLN A 472 REMARK 465 SER A 473 REMARK 465 ARG A 474 REMARK 465 LYS A 475 REMARK 465 PRO A 476 REMARK 465 PRO A 477 REMARK 465 ASN A 478 REMARK 465 PRO A 479 REMARK 465 THR A 480 REMARK 465 PRO A 481 REMARK 465 PRO A 482 REMARK 465 PRO A 483 REMARK 465 PRO A 484 REMARK 465 GLY A 485 REMARK 465 ALA A 486 REMARK 465 SER A 487 REMARK 465 ALA A 488 REMARK 465 ASN A 489 REMARK 465 ALA A 490 REMARK 465 SER A 491 REMARK 465 ALA D 125 REMARK 465 SER D 126 REMARK 465 THR D 127 REMARK 465 LYS D 128 REMARK 465 GLY D 129 REMARK 465 PRO D 130 REMARK 465 SER D 131 REMARK 465 VAL D 132 REMARK 465 PHE D 133 REMARK 465 PRO D 134 REMARK 465 LEU D 135 REMARK 465 ALA D 136 REMARK 465 PRO D 137 REMARK 465 SER D 138 REMARK 465 SER D 139 REMARK 465 LYS D 140 REMARK 465 SER D 141 REMARK 465 THR D 142 REMARK 465 SER D 143 REMARK 465 GLY D 144 REMARK 465 GLY D 145 REMARK 465 THR D 146 REMARK 465 ALA D 147 REMARK 465 ALA D 148 REMARK 465 LEU D 149 REMARK 465 GLY D 150 REMARK 465 CYS D 151 REMARK 465 LEU D 152 REMARK 465 VAL D 153 REMARK 465 LYS D 154 REMARK 465 ASP D 155 REMARK 465 TYR D 156 REMARK 465 PHE D 157 REMARK 465 PRO D 158 REMARK 465 GLU D 159 REMARK 465 PRO D 160 REMARK 465 VAL D 161 REMARK 465 THR D 162 REMARK 465 VAL D 163 REMARK 465 SER D 164 REMARK 465 TRP D 165 REMARK 465 ASN D 166 REMARK 465 SER D 167 REMARK 465 GLY D 168 REMARK 465 ALA D 169 REMARK 465 LEU D 170 REMARK 465 THR D 171 REMARK 465 SER D 172 REMARK 465 GLY D 173 REMARK 465 VAL D 174 REMARK 465 HIS D 175 REMARK 465 THR D 176 REMARK 465 PHE D 177 REMARK 465 PRO D 178 REMARK 465 ALA D 179 REMARK 465 VAL D 180 REMARK 465 LEU D 181 REMARK 465 GLN D 182 REMARK 465 SER D 183 REMARK 465 SER D 184 REMARK 465 GLY D 185 REMARK 465 LEU D 186 REMARK 465 TYR D 187 REMARK 465 SER D 188 REMARK 465 LEU D 189 REMARK 465 SER D 190 REMARK 465 SER D 191 REMARK 465 VAL D 192 REMARK 465 VAL D 193 REMARK 465 THR D 194 REMARK 465 VAL D 195 REMARK 465 PRO D 196 REMARK 465 SER D 197 REMARK 465 SER D 198 REMARK 465 SER D 199 REMARK 465 LEU D 200 REMARK 465 GLY D 201 REMARK 465 THR D 202 REMARK 465 GLN D 203 REMARK 465 THR D 204 REMARK 465 TYR D 205 REMARK 465 ILE D 206 REMARK 465 CYS D 207 REMARK 465 ASN D 208 REMARK 465 VAL D 209 REMARK 465 ASN D 210 REMARK 465 HIS D 211 REMARK 465 LYS D 212 REMARK 465 PRO D 213 REMARK 465 SER D 214 REMARK 465 ASN D 215 REMARK 465 THR D 216 REMARK 465 LYS D 217 REMARK 465 VAL D 218 REMARK 465 ASP D 219 REMARK 465 LYS D 220 REMARK 465 ARG D 221 REMARK 465 VAL D 222 REMARK 465 GLY D 223 REMARK 465 SER D 224 REMARK 465 HIS D 225 REMARK 465 HIS D 226 REMARK 465 HIS D 227 REMARK 465 HIS D 228 REMARK 465 HIS D 229 REMARK 465 HIS D 230 REMARK 465 ARG F 108 REMARK 465 THR F 109 REMARK 465 VAL F 110 REMARK 465 ALA F 111 REMARK 465 ALA F 112 REMARK 465 PRO F 113 REMARK 465 SER F 114 REMARK 465 VAL F 115 REMARK 465 PHE F 116 REMARK 465 ILE F 117 REMARK 465 PHE F 118 REMARK 465 PRO F 119 REMARK 465 PRO F 120 REMARK 465 SER F 121 REMARK 465 ASP F 122 REMARK 465 GLU F 123 REMARK 465 GLN F 124 REMARK 465 LEU F 125 REMARK 465 LYS F 126 REMARK 465 SER F 127 REMARK 465 GLY F 128 REMARK 465 THR F 129 REMARK 465 ALA F 130 REMARK 465 SER F 131 REMARK 465 VAL F 132 REMARK 465 VAL F 133 REMARK 465 CYS F 134 REMARK 465 LEU F 135 REMARK 465 LEU F 136 REMARK 465 ASN F 137 REMARK 465 ASN F 138 REMARK 465 PHE F 139 REMARK 465 TYR F 140 REMARK 465 PRO F 141 REMARK 465 ARG F 142 REMARK 465 GLU F 143 REMARK 465 ALA F 144 REMARK 465 LYS F 145 REMARK 465 VAL F 146 REMARK 465 GLN F 147 REMARK 465 TRP F 148 REMARK 465 LYS F 149 REMARK 465 VAL F 150 REMARK 465 ASP F 151 REMARK 465 ASN F 152 REMARK 465 ALA F 153 REMARK 465 LEU F 154 REMARK 465 GLN F 155 REMARK 465 SER F 156 REMARK 465 GLY F 157 REMARK 465 ASN F 158 REMARK 465 SER F 159 REMARK 465 GLN F 160 REMARK 465 GLU F 161 REMARK 465 SER F 162 REMARK 465 VAL F 163 REMARK 465 THR F 164 REMARK 465 GLU F 165 REMARK 465 GLN F 166 REMARK 465 ASP F 167 REMARK 465 SER F 168 REMARK 465 LYS F 169 REMARK 465 ASP F 170 REMARK 465 SER F 171 REMARK 465 THR F 172 REMARK 465 TYR F 173 REMARK 465 SER F 174 REMARK 465 LEU F 175 REMARK 465 SER F 176 REMARK 465 SER F 177 REMARK 465 THR F 178 REMARK 465 LEU F 179 REMARK 465 THR F 180 REMARK 465 LEU F 181 REMARK 465 SER F 182 REMARK 465 LYS F 183 REMARK 465 ALA F 184 REMARK 465 ASP F 185 REMARK 465 TYR F 186 REMARK 465 GLU F 187 REMARK 465 LYS F 188 REMARK 465 HIS F 189 REMARK 465 LYS F 190 REMARK 465 VAL F 191 REMARK 465 TYR F 192 REMARK 465 ALA F 193 REMARK 465 CYS F 194 REMARK 465 GLU F 195 REMARK 465 VAL F 196 REMARK 465 THR F 197 REMARK 465 HIS F 198 REMARK 465 GLN F 199 REMARK 465 GLY F 200 REMARK 465 LEU F 201 REMARK 465 SER F 202 REMARK 465 SER F 203 REMARK 465 PRO F 204 REMARK 465 VAL F 205 REMARK 465 THR F 206 REMARK 465 LYS F 207 REMARK 465 SER F 208 REMARK 465 PHE F 209 REMARK 465 ASN F 210 REMARK 465 ARG F 211 REMARK 465 GLY F 212 REMARK 465 GLU F 213 REMARK 465 CYS F 214 REMARK 465 THR B 331 REMARK 465 THR B 332 REMARK 465 LYS B 333 REMARK 465 ALA B 334 REMARK 465 ARG B 335 REMARK 465 ALA B 336 REMARK 465 THR B 337 REMARK 465 LEU B 460 REMARK 465 ALA B 461 REMARK 465 GLU B 462 REMARK 465 LEU B 463 REMARK 465 TYR B 464 REMARK 465 VAL B 465 REMARK 465 ARG B 466 REMARK 465 GLU B 467 REMARK 465 HIS B 468 REMARK 465 LEU B 469 REMARK 465 ARG B 470 REMARK 465 GLU B 471 REMARK 465 GLN B 472 REMARK 465 SER B 473 REMARK 465 ARG B 474 REMARK 465 LYS B 475 REMARK 465 PRO B 476 REMARK 465 PRO B 477 REMARK 465 ASN B 478 REMARK 465 PRO B 479 REMARK 465 THR B 480 REMARK 465 PRO B 481 REMARK 465 PRO B 482 REMARK 465 PRO B 483 REMARK 465 PRO B 484 REMARK 465 GLY B 485 REMARK 465 ALA B 486 REMARK 465 SER B 487 REMARK 465 ALA B 488 REMARK 465 ASN B 489 REMARK 465 ALA B 490 REMARK 465 SER B 491 REMARK 465 ALA E 125 REMARK 465 SER E 126 REMARK 465 THR E 127 REMARK 465 LYS E 128 REMARK 465 GLY E 129 REMARK 465 PRO E 130 REMARK 465 SER E 131 REMARK 465 VAL E 132 REMARK 465 PHE E 133 REMARK 465 PRO E 134 REMARK 465 LEU E 135 REMARK 465 ALA E 136 REMARK 465 PRO E 137 REMARK 465 SER E 138 REMARK 465 SER E 139 REMARK 465 LYS E 140 REMARK 465 SER E 141 REMARK 465 THR E 142 REMARK 465 SER E 143 REMARK 465 GLY E 144 REMARK 465 GLY E 145 REMARK 465 THR E 146 REMARK 465 ALA E 147 REMARK 465 ALA E 148 REMARK 465 LEU E 149 REMARK 465 GLY E 150 REMARK 465 CYS E 151 REMARK 465 LEU E 152 REMARK 465 VAL E 153 REMARK 465 LYS E 154 REMARK 465 ASP E 155 REMARK 465 TYR E 156 REMARK 465 PHE E 157 REMARK 465 PRO E 158 REMARK 465 GLU E 159 REMARK 465 PRO E 160 REMARK 465 VAL E 161 REMARK 465 THR E 162 REMARK 465 VAL E 163 REMARK 465 SER E 164 REMARK 465 TRP E 165 REMARK 465 ASN E 166 REMARK 465 SER E 167 REMARK 465 GLY E 168 REMARK 465 ALA E 169 REMARK 465 LEU E 170 REMARK 465 THR E 171 REMARK 465 SER E 172 REMARK 465 GLY E 173 REMARK 465 VAL E 174 REMARK 465 HIS E 175 REMARK 465 THR E 176 REMARK 465 PHE E 177 REMARK 465 PRO E 178 REMARK 465 ALA E 179 REMARK 465 VAL E 180 REMARK 465 LEU E 181 REMARK 465 GLN E 182 REMARK 465 SER E 183 REMARK 465 SER E 184 REMARK 465 GLY E 185 REMARK 465 LEU E 186 REMARK 465 TYR E 187 REMARK 465 SER E 188 REMARK 465 LEU E 189 REMARK 465 SER E 190 REMARK 465 SER E 191 REMARK 465 VAL E 192 REMARK 465 VAL E 193 REMARK 465 THR E 194 REMARK 465 VAL E 195 REMARK 465 PRO E 196 REMARK 465 SER E 197 REMARK 465 SER E 198 REMARK 465 SER E 199 REMARK 465 LEU E 200 REMARK 465 GLY E 201 REMARK 465 THR E 202 REMARK 465 GLN E 203 REMARK 465 THR E 204 REMARK 465 TYR E 205 REMARK 465 ILE E 206 REMARK 465 CYS E 207 REMARK 465 ASN E 208 REMARK 465 VAL E 209 REMARK 465 ASN E 210 REMARK 465 HIS E 211 REMARK 465 LYS E 212 REMARK 465 PRO E 213 REMARK 465 SER E 214 REMARK 465 ASN E 215 REMARK 465 THR E 216 REMARK 465 LYS E 217 REMARK 465 VAL E 218 REMARK 465 ASP E 219 REMARK 465 LYS E 220 REMARK 465 ARG E 221 REMARK 465 VAL E 222 REMARK 465 GLY E 223 REMARK 465 SER E 224 REMARK 465 HIS E 225 REMARK 465 HIS E 226 REMARK 465 HIS E 227 REMARK 465 HIS E 228 REMARK 465 HIS E 229 REMARK 465 HIS E 230 REMARK 465 ARG G 108 REMARK 465 THR G 109 REMARK 465 VAL G 110 REMARK 465 ALA G 111 REMARK 465 ALA G 112 REMARK 465 PRO G 113 REMARK 465 SER G 114 REMARK 465 VAL G 115 REMARK 465 PHE G 116 REMARK 465 ILE G 117 REMARK 465 PHE G 118 REMARK 465 PRO G 119 REMARK 465 PRO G 120 REMARK 465 SER G 121 REMARK 465 ASP G 122 REMARK 465 GLU G 123 REMARK 465 GLN G 124 REMARK 465 LEU G 125 REMARK 465 LYS G 126 REMARK 465 SER G 127 REMARK 465 GLY G 128 REMARK 465 THR G 129 REMARK 465 ALA G 130 REMARK 465 SER G 131 REMARK 465 VAL G 132 REMARK 465 VAL G 133 REMARK 465 CYS G 134 REMARK 465 LEU G 135 REMARK 465 LEU G 136 REMARK 465 ASN G 137 REMARK 465 ASN G 138 REMARK 465 PHE G 139 REMARK 465 TYR G 140 REMARK 465 PRO G 141 REMARK 465 ARG G 142 REMARK 465 GLU G 143 REMARK 465 ALA G 144 REMARK 465 LYS G 145 REMARK 465 VAL G 146 REMARK 465 GLN G 147 REMARK 465 TRP G 148 REMARK 465 LYS G 149 REMARK 465 VAL G 150 REMARK 465 ASP G 151 REMARK 465 ASN G 152 REMARK 465 ALA G 153 REMARK 465 LEU G 154 REMARK 465 GLN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ASN G 158 REMARK 465 SER G 159 REMARK 465 GLN G 160 REMARK 465 GLU G 161 REMARK 465 SER G 162 REMARK 465 VAL G 163 REMARK 465 THR G 164 REMARK 465 GLU G 165 REMARK 465 GLN G 166 REMARK 465 ASP G 167 REMARK 465 SER G 168 REMARK 465 LYS G 169 REMARK 465 ASP G 170 REMARK 465 SER G 171 REMARK 465 THR G 172 REMARK 465 TYR G 173 REMARK 465 SER G 174 REMARK 465 LEU G 175 REMARK 465 SER G 176 REMARK 465 SER G 177 REMARK 465 THR G 178 REMARK 465 LEU G 179 REMARK 465 THR G 180 REMARK 465 LEU G 181 REMARK 465 SER G 182 REMARK 465 LYS G 183 REMARK 465 ALA G 184 REMARK 465 ASP G 185 REMARK 465 TYR G 186 REMARK 465 GLU G 187 REMARK 465 LYS G 188 REMARK 465 HIS G 189 REMARK 465 LYS G 190 REMARK 465 VAL G 191 REMARK 465 TYR G 192 REMARK 465 ALA G 193 REMARK 465 CYS G 194 REMARK 465 GLU G 195 REMARK 465 VAL G 196 REMARK 465 THR G 197 REMARK 465 HIS G 198 REMARK 465 GLN G 199 REMARK 465 GLY G 200 REMARK 465 LEU G 201 REMARK 465 SER G 202 REMARK 465 SER G 203 REMARK 465 PRO G 204 REMARK 465 VAL G 205 REMARK 465 THR G 206 REMARK 465 LYS G 207 REMARK 465 SER G 208 REMARK 465 PHE G 209 REMARK 465 ASN G 210 REMARK 465 ARG G 211 REMARK 465 GLY G 212 REMARK 465 GLU G 213 REMARK 465 CYS G 214 REMARK 465 THR C 331 REMARK 465 THR C 332 REMARK 465 LYS C 333 REMARK 465 ALA C 334 REMARK 465 ARG C 335 REMARK 465 ALA C 336 REMARK 465 THR C 337 REMARK 465 LEU C 460 REMARK 465 ALA C 461 REMARK 465 GLU C 462 REMARK 465 LEU C 463 REMARK 465 TYR C 464 REMARK 465 VAL C 465 REMARK 465 ARG C 466 REMARK 465 GLU C 467 REMARK 465 HIS C 468 REMARK 465 LEU C 469 REMARK 465 ARG C 470 REMARK 465 GLU C 471 REMARK 465 GLN C 472 REMARK 465 SER C 473 REMARK 465 ARG C 474 REMARK 465 LYS C 475 REMARK 465 PRO C 476 REMARK 465 PRO C 477 REMARK 465 ASN C 478 REMARK 465 PRO C 479 REMARK 465 THR C 480 REMARK 465 PRO C 481 REMARK 465 PRO C 482 REMARK 465 PRO C 483 REMARK 465 PRO C 484 REMARK 465 GLY C 485 REMARK 465 ALA C 486 REMARK 465 SER C 487 REMARK 465 ALA C 488 REMARK 465 ASN C 489 REMARK 465 ALA C 490 REMARK 465 SER C 491 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 CYS H 22 SG REMARK 470 PHE H 27 CG CD1 CD2 CE1 CE2 CZ REMARK 470 ILE H 57 CD1 REMARK 470 GLN H 59 CG CD OE1 NE2 REMARK 470 LEU H 86 CG CD1 CD2 REMARK 470 CYS H 96 SG REMARK 470 TYR H 109 OH REMARK 470 CYS L 23 SG REMARK 470 ILE L 75 CG1 CG2 CD1 REMARK 470 LYS L 76 CG CD CE NZ REMARK 470 ASN L 77 CG OD1 ND2 REMARK 470 MET L 78 CG SD CE REMARK 470 GLN L 79 CG CD OE1 NE2 REMARK 470 PRO L 80 CG CD REMARK 470 GLU L 81 CG CD OE1 OE2 REMARK 470 ASP L 82 CG OD1 OD2 REMARK 470 PHE L 83 CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR L 85 OG1 CG2 REMARK 470 CYS L 88 SG REMARK 470 CYS A 116 SG REMARK 470 GLN A 129 CG CD OE1 NE2 REMARK 470 ARG A 131 CG CD NE CZ NH1 NH2 REMARK 470 CYS A 133 SG REMARK 470 GLU A 144 CG CD OE1 OE2 REMARK 470 ARG A 178 CG CD NE CZ NH1 NH2 REMARK 470 CYS A 207 SG REMARK 470 ARG A 215 NH1 NH2 REMARK 470 ARG A 242 CG CD NE CZ NH1 NH2 REMARK 470 ARG A 258 CG CD NE CZ NH1 NH2 REMARK 470 CYS A 271 SG REMARK 470 ARG A 318 CG CD NE CZ NH1 NH2 REMARK 470 SER A 362 OG REMARK 470 CYS A 364 SG REMARK 470 GLU A 374 CG CD OE1 OE2 REMARK 470 TYR A 380 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ARG A 385 CG CD NE CZ NH1 NH2 REMARK 470 THR A 397 OG1 CG2 REMARK 470 GLU A 401 CG CD OE1 OE2 REMARK 470 ARG A 406 CG CD NE CZ NH1 NH2 REMARK 470 CYS A 412 SG REMARK 470 ARG A 423 CG CD NE CZ NH1 NH2 REMARK 470 ARG A 494 CG CD NE CZ NH1 NH2 REMARK 470 ILE A 501 CG1 CG2 CD1 REMARK 470 CYS A 529 SG REMARK 470 ASN A 540 CG OD1 ND2 REMARK 470 GLU A 541 CG CD OE1 OE2 REMARK 470 LYS A 544 CG CD CE NZ REMARK 470 ARG A 557 CG CD NE CZ NH1 NH2 REMARK 470 ARG A 558 CG CD NE CZ NH1 NH2 REMARK 470 SER A 560 CB REMARK 470 ARG A 562 CG CD NE CZ NH1 NH2 REMARK 470 MET A 563 CG SD CE REMARK 470 LEU A 564 CG CD1 CD2 REMARK 470 ASP A 566 CG OD1 OD2 REMARK 470 VAL A 567 CG1 CG2 REMARK 470 MET A 568 CG SD CE REMARK 470 THR A 572 OG1 CG2 REMARK 470 CYS A 573 SG REMARK 470 VAL A 574 CG1 CG2 REMARK 470 CYS A 596 SG REMARK 470 ARG A 605 CG CD NE CZ NH1 NH2 REMARK 470 GLN A 609 CG CD OE1 NE2 REMARK 470 GLU A 614 CG CD OE1 OE2 REMARK 470 ASP A 628 CG OD1 OD2 REMARK 470 CYS A 633 SG REMARK 470 VAL A 635 CG1 CG2 REMARK 470 ARG A 638 CG CD NE CZ NH1 NH2 REMARK 470 TYR A 647 OH REMARK 470 GLU A 682 CG CD OE1 OE2 REMARK 470 ARG A 691 NH1 NH2 REMARK 470 ASP A 713 CG OD1 OD2 REMARK 470 ARG A 715 CG CD NE CZ NH1 NH2 REMARK 470 ARG D 13 CG CD NE CZ NH1 NH2 REMARK 470 ARG D 16 CG CD NE CZ NH1 NH2 REMARK 470 CYS D 22 SG REMARK 470 MET D 83 CG SD CE REMARK 470 CYS D 96 SG REMARK 470 CYS F 23 SG REMARK 470 ILE F 75 CG1 CG2 CD1 REMARK 470 LYS F 76 CG CD CE NZ REMARK 470 ASN F 77 CG OD1 ND2 REMARK 470 MET F 78 CG SD CE REMARK 470 GLN F 79 CG CD OE1 NE2 REMARK 470 PRO F 80 CG CD REMARK 470 GLU F 81 CG CD OE1 OE2 REMARK 470 ASP F 82 CG OD1 OD2 REMARK 470 PHE F 83 CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR F 85 OG1 CG2 REMARK 470 CYS F 88 SG REMARK 470 CYS B 116 SG REMARK 470 ARG B 131 CG CD NE CZ NH1 NH2 REMARK 470 CYS B 133 SG REMARK 470 GLU B 138 CG CD OE1 OE2 REMARK 470 GLU B 144 CG CD OE1 OE2 REMARK 470 CYS B 207 SG REMARK 470 ARG B 242 CG CD NE CZ NH1 NH2 REMARK 470 ARG B 258 CG CD NE CZ NH1 NH2 REMARK 470 CYS B 271 SG REMARK 470 THR B 313 OG1 CG2 REMARK 470 ARG B 318 CG CD NE CZ NH1 NH2 REMARK 470 CYS B 364 SG REMARK 470 TYR B 380 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ARG B 385 CG CD NE CZ NH1 NH2 REMARK 470 THR B 397 OG1 CG2 REMARK 470 ARG B 406 CG CD NE CZ NH1 NH2 REMARK 470 CYS B 412 SG REMARK 470 ARG B 423 CG CD NE CZ NH1 NH2 REMARK 470 ARG B 428 CG CD NE CZ NH1 NH2 REMARK 470 ARG B 494 CG CD NE CZ NH1 NH2 REMARK 470 MET B 520 CE REMARK 470 CYS B 529 SG REMARK 470 ASN B 540 CG OD1 ND2 REMARK 470 GLU B 541 CG CD OE1 OE2 REMARK 470 LYS B 544 CG CD CE NZ REMARK 470 ARG B 557 CG CD NE CZ NH1 NH2 REMARK 470 ARG B 558 CG CD NE CZ NH1 NH2 REMARK 470 SER B 560 OG REMARK 470 ALA B 561 CB REMARK 470 ARG B 562 CG CD NE CZ NH1 NH2 REMARK 470 MET B 563 CG SD CE REMARK 470 LEU B 564 CG CD1 CD2 REMARK 470 ASP B 566 CG OD1 OD2 REMARK 470 VAL B 567 CG1 CG2 REMARK 470 MET B 568 CG SD CE REMARK 470 CYS B 573 SG REMARK 470 VAL B 574 CG1 CG2 REMARK 470 CYS B 596 SG REMARK 470 ARG B 605 NH1 REMARK 470 GLN B 609 CG CD OE1 NE2 REMARK 470 GLU B 614 CG CD OE1 OE2 REMARK 470 ASP B 628 CG OD1 OD2 REMARK 470 CYS B 633 SG REMARK 470 VAL B 635 CG1 CG2 REMARK 470 ARG B 638 CG CD NE CZ NH1 NH2 REMARK 470 TYR B 647 OH REMARK 470 ARG B 708 NH1 NH2 REMARK 470 ARG B 715 CG CD NE CZ NH1 NH2 REMARK 470 CYS E 22 SG REMARK 470 MET E 83 CG SD CE REMARK 470 CYS E 96 SG REMARK 470 CYS G 23 SG REMARK 470 ARG G 38 CG CD NE CZ NH1 NH2 REMARK 470 ILE G 75 CG1 CG2 CD1 REMARK 470 LYS G 76 CG CD CE NZ REMARK 470 ASN G 77 CG OD1 ND2 REMARK 470 MET G 78 CG SD CE REMARK 470 GLN G 79 CG CD OE1 NE2 REMARK 470 PRO G 80 CG CD REMARK 470 GLU G 81 CG CD OE1 OE2 REMARK 470 ASP G 82 CG OD1 OD2 REMARK 470 PHE G 83 CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR G 85 OG1 CG2 REMARK 470 CYS G 88 SG REMARK 470 CYS C 116 SG REMARK 470 ARG C 131 CG CD NE CZ NH1 NH2 REMARK 470 CYS C 133 SG REMARK 470 PHE C 194 CG CD1 CD2 CE1 CE2 CZ REMARK 470 CYS C 207 SG REMARK 470 ARG C 242 CG CD NE CZ NH1 NH2 REMARK 470 ARG C 258 CG CD NE CZ NH1 NH2 REMARK 470 CYS C 271 SG REMARK 470 ARG C 318 CG CD NE CZ NH1 NH2 REMARK 470 LYS C 320 CE NZ REMARK 470 CYS C 364 SG REMARK 470 ARG C 385 NH1 NH2 REMARK 470 THR C 397 OG1 CG2 REMARK 470 ARG C 406 CG CD NE CZ NH1 NH2 REMARK 470 CYS C 412 SG REMARK 470 ARG C 423 CG CD NE CZ NH1 NH2 REMARK 470 ARG C 494 CG CD NE CZ NH1 NH2 REMARK 470 ILE C 501 CG1 CG2 CD1 REMARK 470 CYS C 529 SG REMARK 470 ASN C 540 CG OD1 ND2 REMARK 470 GLU C 541 CG CD OE1 OE2 REMARK 470 LYS C 544 CG CD CE NZ REMARK 470 VAL C 553 CG1 CG2 REMARK 470 ARG C 557 CG CD NE CZ NH1 NH2 REMARK 470 ARG C 558 CG CD NE CZ NH1 NH2 REMARK 470 SER C 560 CB OG REMARK 470 ARG C 562 CG CD NE CZ NH1 NH2 REMARK 470 MET C 563 CG SD CE REMARK 470 LEU C 564 CG CD1 CD2 REMARK 470 ASP C 566 CG OD1 OD2 REMARK 470 VAL C 567 CG1 CG2 REMARK 470 MET C 568 CG SD CE REMARK 470 CYS C 573 SG REMARK 470 VAL C 574 CG1 CG2 REMARK 470 MET C 587 CG SD CE REMARK 470 CYS C 596 SG REMARK 470 TYR C 597 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 GLN C 609 CG CD OE1 NE2 REMARK 470 GLU C 614 CG CD OE1 OE2 REMARK 470 ASP C 628 CG OD1 OD2 REMARK 470 CYS C 633 SG REMARK 470 VAL C 635 CG1 CG2 REMARK 470 ARG C 638 CG CD NE CZ NH1 NH2 REMARK 470 TYR C 647 OH REMARK 470 ARG C 661 CG CD NE CZ NH1 NH2 REMARK 470 GLU C 687 CG CD OE1 OE2 REMARK 470 ARG C 691 NH1 NH2 REMARK 470 ARG C 708 CG CD NE CZ NH1 NH2 REMARK 470 ARG C 715 CG CD NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 VAL H 48 -60.03 -122.61 REMARK 500 ALA L 51 -10.34 73.65 REMARK 500 TYR L 52 29.66 -145.51 REMARK 500 TYR L 91 30.31 -140.32 REMARK 500 ARG A 225 16.77 57.43 REMARK 500 SER A 244 -168.62 -79.81 REMARK 500 PRO A 283 31.04 -88.71 REMARK 500 ALA A 327 -167.50 -78.25 REMARK 500 PRO D 14 75.59 -66.89 REMARK 500 ARG D 16 -142.16 58.59 REMARK 500 VAL D 48 -62.26 -122.50 REMARK 500 ALA F 51 -10.05 73.25 REMARK 500 ARG B 178 -31.02 -131.03 REMARK 500 ARG B 225 11.22 58.83 REMARK 500 SER B 244 -168.62 -79.71 REMARK 500 ALA B 327 -166.92 -78.39 REMARK 500 TRP B 369 -61.20 -95.87 REMARK 500 PHE E 29 48.80 -92.02 REMARK 500 ALA G 51 -10.25 73.48 REMARK 500 TYR G 52 29.74 -145.18 REMARK 500 ARG C 225 14.80 58.03 REMARK 500 SER C 244 -168.87 -79.76 REMARK 500 ALA C 327 -167.84 -78.20 REMARK 500 LEU C 345 148.26 -170.50 REMARK 500 TRP C 369 -60.15 -94.51 REMARK 500 SER C 499 -163.53 55.14 REMARK 500 ILE C 501 1.06 -67.55 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-37203 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF HSV-1 GB WITH D48 FAB COMPLEX DBREF 8KFA H 1 230 PDB 8KFA 8KFA 1 230 DBREF 8KFA L 1 214 PDB 8KFA 8KFA 1 214 DBREF 8KFA A 111 725 UNP P06437 GB_HHV1K 111 725 DBREF 8KFA D 1 230 PDB 8KFA 8KFA 1 230 DBREF 8KFA F 1 214 PDB 8KFA 8KFA 1 214 DBREF 8KFA B 111 725 UNP P06437 GB_HHV1K 111 725 DBREF 8KFA E 1 230 PDB 8KFA 8KFA 1 230 DBREF 8KFA G 1 214 PDB 8KFA 8KFA 1 214 DBREF 8KFA C 111 725 UNP P06437 GB_HHV1K 111 725 SEQRES 1 H 230 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY VAL VAL ARG SEQRES 2 H 230 PRO GLY ARG SER LEU ARG LEU SER CYS THR THR SER GLY SEQRES 3 H 230 PHE SER PHE SER GLY SER ALA MET HIS TRP VAL ARG GLN SEQRES 4 H 230 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER SEQRES 5 H 230 HIS ASP GLY ASN ILE ILE GLN TYR HIS ASP SER VAL LYS SEQRES 6 H 230 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN VAL SEQRES 7 H 230 LEU LEU LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR SEQRES 8 H 230 ALA MET TYR TYR CYS ALA ARG ASP VAL TRP LEU LEU PRO SEQRES 9 H 230 ALA THR ILE SER TYR ALA PHE ASP PHE TRP GLY GLN GLY SEQRES 10 H 230 THR MET VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 H 230 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 H 230 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 H 230 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 H 230 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 H 230 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 H 230 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 H 230 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG SEQRES 18 H 230 VAL GLY SER HIS HIS HIS HIS HIS HIS SEQRES 1 L 214 VAL ILE TRP MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 L 214 SER ILE GLY ASP THR VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 214 GLN GLY ILE SER ASN SER ILE ALA TRP TYR GLN ARG ARG SEQRES 4 L 214 PRO GLY LYS ALA PRO GLU LEU LEU VAL TYR ALA ALA TYR SEQRES 5 L 214 ARG LEU GLN SER GLY VAL PRO SER ARG LEU SER GLY SER SEQRES 6 L 214 GLY SER GLY ALA GLU TYR THR LEU THR ILE LYS ASN MET SEQRES 7 L 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 L 214 TYR ASP ASN PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 L 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 L 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 L 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 L 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 L 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 L 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 L 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 L 214 PHE ASN ARG GLY GLU CYS SEQRES 1 A 615 ALA ASN PHE TYR VAL CYS PRO PRO PRO THR GLY ALA THR SEQRES 2 A 615 VAL VAL GLN PHE GLU GLN PRO ARG ARG CYS PRO THR ARG SEQRES 3 A 615 PRO GLU GLY GLN ASN TYR THR GLU GLY ILE ALA VAL VAL SEQRES 4 A 615 PHE LYS GLU ASN ILE ALA PRO TYR LYS PHE LYS ALA THR SEQRES 5 A 615 MET TYR TYR LYS ASP VAL THR VAL SER GLN VAL TRP PHE SEQRES 6 A 615 GLY HIS ARG TYR SER GLN PHE MET GLY ILE PHE GLU ASP SEQRES 7 A 615 ARG ALA PRO VAL PRO PHE GLU GLU VAL ILE ASP LYS ILE SEQRES 8 A 615 ASN ALA LYS GLY VAL CYS ARG SER THR ALA LYS TYR VAL SEQRES 9 A 615 ARG ASN ASN LEU GLU THR THR ALA PHE HIS ARG ASP ASP SEQRES 10 A 615 HIS GLU THR ASP MET GLU LEU LYS PRO ALA ASN ALA ALA SEQRES 11 A 615 THR ARG THR SER ARG GLY TRP HIS THR THR ASP LEU LYS SEQRES 12 A 615 TYR ASN PRO SER ARG VAL GLU ALA PHE HIS ARG TYR GLY SEQRES 13 A 615 THR THR VAL ASN CYS ILE VAL GLU GLU VAL ASP ALA ARG SEQRES 14 A 615 SER VAL TYR PRO TYR ASP GLU PHE VAL LEU ALA THR GLY SEQRES 15 A 615 ASP PHE VAL TYR MET SER PRO PHE TYR GLY TYR ARG GLU SEQRES 16 A 615 GLY SER HIS THR GLU HIS THR THR TYR ALA ALA ASP ARG SEQRES 17 A 615 PHE LYS GLN VAL ASP GLY PHE TYR ALA ARG ASP LEU THR SEQRES 18 A 615 THR LYS ALA ARG ALA THR ALA PRO THR THR ARG ASN LEU SEQRES 19 A 615 LEU THR THR PRO LYS PHE THR VAL ALA TRP ASP TRP VAL SEQRES 20 A 615 PRO LYS ARG PRO SER VAL CYS THR MET THR LYS TRP GLN SEQRES 21 A 615 GLU VAL ASP GLU MET LEU ARG SER GLU TYR GLY GLY SER SEQRES 22 A 615 PHE ARG PHE SER SER ASP ALA ILE SER THR THR PHE THR SEQRES 23 A 615 THR ASN LEU THR GLU TYR PRO LEU SER ARG VAL ASP LEU SEQRES 24 A 615 GLY ASP CYS ILE GLY LYS ASP ALA ARG ASP ALA MET ASP SEQRES 25 A 615 ARG ILE PHE ALA ARG ARG TYR ASN ALA THR HIS ILE LYS SEQRES 26 A 615 VAL GLY GLN PRO GLN TYR TYR GLN ALA ASN GLY GLY PHE SEQRES 27 A 615 LEU ILE ALA TYR GLN PRO LEU LEU SER ASN THR LEU ALA SEQRES 28 A 615 GLU LEU TYR VAL ARG GLU HIS LEU ARG GLU GLN SER ARG SEQRES 29 A 615 LYS PRO PRO ASN PRO THR PRO PRO PRO PRO GLY ALA SER SEQRES 30 A 615 ALA ASN ALA SER VAL GLU ARG ILE LYS THR THR SER SER SEQRES 31 A 615 ILE GLU PHE ALA ARG LEU GLN PHE THR TYR ASN HIS ILE SEQRES 32 A 615 GLN ARG HIS VAL ASN ASP MET LEU GLY ARG VAL ALA ILE SEQRES 33 A 615 ALA TRP CYS GLU LEU GLN ASN HIS GLU LEU THR LEU TRP SEQRES 34 A 615 ASN GLU ALA ARG LYS LEU ASN PRO ASN ALA ILE ALA SER SEQRES 35 A 615 VAL THR VAL GLY ARG ARG VAL SER ALA ARG MET LEU GLY SEQRES 36 A 615 ASP VAL MET ALA VAL SER THR CYS VAL PRO VAL ALA ALA SEQRES 37 A 615 ASP ASN VAL ILE VAL GLN ASN SER MET ARG ILE SER SER SEQRES 38 A 615 ARG PRO GLY ALA CYS TYR SER ARG PRO LEU VAL SER PHE SEQRES 39 A 615 ARG TYR GLU ASP GLN GLY PRO LEU VAL GLU GLY GLN LEU SEQRES 40 A 615 GLY GLU ASN ASN GLU LEU ARG LEU THR ARG ASP ALA ILE SEQRES 41 A 615 GLU PRO CYS THR VAL GLY HIS ARG ARG TYR PHE THR PHE SEQRES 42 A 615 GLY GLY GLY TYR VAL TYR PHE GLU GLU TYR ALA TYR SER SEQRES 43 A 615 HIS GLN LEU SER ARG ALA ASP ILE THR THR VAL SER THR SEQRES 44 A 615 PHE ILE ASP LEU ASN ILE THR MET LEU GLU ASP HIS GLU SEQRES 45 A 615 PHE VAL PRO LEU GLU VAL TYR THR ARG HIS GLU ILE LYS SEQRES 46 A 615 ASP SER GLY LEU LEU ASP TYR THR GLU VAL GLN ARG ARG SEQRES 47 A 615 ASN GLN LEU HIS ASP LEU ARG PHE ALA ASP ILE ASP THR SEQRES 48 A 615 VAL ILE HIS ALA SEQRES 1 D 230 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY VAL VAL ARG SEQRES 2 D 230 PRO GLY ARG SER LEU ARG LEU SER CYS THR THR SER GLY SEQRES 3 D 230 PHE SER PHE SER GLY SER ALA MET HIS TRP VAL ARG GLN SEQRES 4 D 230 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER SEQRES 5 D 230 HIS ASP GLY ASN ILE ILE GLN TYR HIS ASP SER VAL LYS SEQRES 6 D 230 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN VAL SEQRES 7 D 230 LEU LEU LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR SEQRES 8 D 230 ALA MET TYR TYR CYS ALA ARG ASP VAL TRP LEU LEU PRO SEQRES 9 D 230 ALA THR ILE SER TYR ALA PHE ASP PHE TRP GLY GLN GLY SEQRES 10 D 230 THR MET VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 D 230 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 D 230 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 D 230 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 D 230 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 D 230 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 D 230 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 D 230 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG SEQRES 18 D 230 VAL GLY SER HIS HIS HIS HIS HIS HIS SEQRES 1 F 214 VAL ILE TRP MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 F 214 SER ILE GLY ASP THR VAL THR ILE THR CYS ARG ALA SER SEQRES 3 F 214 GLN GLY ILE SER ASN SER ILE ALA TRP TYR GLN ARG ARG SEQRES 4 F 214 PRO GLY LYS ALA PRO GLU LEU LEU VAL TYR ALA ALA TYR SEQRES 5 F 214 ARG LEU GLN SER GLY VAL PRO SER ARG LEU SER GLY SER SEQRES 6 F 214 GLY SER GLY ALA GLU TYR THR LEU THR ILE LYS ASN MET SEQRES 7 F 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 F 214 TYR ASP ASN PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 F 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 F 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 F 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 F 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 F 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 F 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 F 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 F 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 F 214 PHE ASN ARG GLY GLU CYS SEQRES 1 B 615 ALA ASN PHE TYR VAL CYS PRO PRO PRO THR GLY ALA THR SEQRES 2 B 615 VAL VAL GLN PHE GLU GLN PRO ARG ARG CYS PRO THR ARG SEQRES 3 B 615 PRO GLU GLY GLN ASN TYR THR GLU GLY ILE ALA VAL VAL SEQRES 4 B 615 PHE LYS GLU ASN ILE ALA PRO TYR LYS PHE LYS ALA THR SEQRES 5 B 615 MET TYR TYR LYS ASP VAL THR VAL SER GLN VAL TRP PHE SEQRES 6 B 615 GLY HIS ARG TYR SER GLN PHE MET GLY ILE PHE GLU ASP SEQRES 7 B 615 ARG ALA PRO VAL PRO PHE GLU GLU VAL ILE ASP LYS ILE SEQRES 8 B 615 ASN ALA LYS GLY VAL CYS ARG SER THR ALA LYS TYR VAL SEQRES 9 B 615 ARG ASN ASN LEU GLU THR THR ALA PHE HIS ARG ASP ASP SEQRES 10 B 615 HIS GLU THR ASP MET GLU LEU LYS PRO ALA ASN ALA ALA SEQRES 11 B 615 THR ARG THR SER ARG GLY TRP HIS THR THR ASP LEU LYS SEQRES 12 B 615 TYR ASN PRO SER ARG VAL GLU ALA PHE HIS ARG TYR GLY SEQRES 13 B 615 THR THR VAL ASN CYS ILE VAL GLU GLU VAL ASP ALA ARG SEQRES 14 B 615 SER VAL TYR PRO TYR ASP GLU PHE VAL LEU ALA THR GLY SEQRES 15 B 615 ASP PHE VAL TYR MET SER PRO PHE TYR GLY TYR ARG GLU SEQRES 16 B 615 GLY SER HIS THR GLU HIS THR THR TYR ALA ALA ASP ARG SEQRES 17 B 615 PHE LYS GLN VAL ASP GLY PHE TYR ALA ARG ASP LEU THR SEQRES 18 B 615 THR LYS ALA ARG ALA THR ALA PRO THR THR ARG ASN LEU SEQRES 19 B 615 LEU THR THR PRO LYS PHE THR VAL ALA TRP ASP TRP VAL SEQRES 20 B 615 PRO LYS ARG PRO SER VAL CYS THR MET THR LYS TRP GLN SEQRES 21 B 615 GLU VAL ASP GLU MET LEU ARG SER GLU TYR GLY GLY SER SEQRES 22 B 615 PHE ARG PHE SER SER ASP ALA ILE SER THR THR PHE THR SEQRES 23 B 615 THR ASN LEU THR GLU TYR PRO LEU SER ARG VAL ASP LEU SEQRES 24 B 615 GLY ASP CYS ILE GLY LYS ASP ALA ARG ASP ALA MET ASP SEQRES 25 B 615 ARG ILE PHE ALA ARG ARG TYR ASN ALA THR HIS ILE LYS SEQRES 26 B 615 VAL GLY GLN PRO GLN TYR TYR GLN ALA ASN GLY GLY PHE SEQRES 27 B 615 LEU ILE ALA TYR GLN PRO LEU LEU SER ASN THR LEU ALA SEQRES 28 B 615 GLU LEU TYR VAL ARG GLU HIS LEU ARG GLU GLN SER ARG SEQRES 29 B 615 LYS PRO PRO ASN PRO THR PRO PRO PRO PRO GLY ALA SER SEQRES 30 B 615 ALA ASN ALA SER VAL GLU ARG ILE LYS THR THR SER SER SEQRES 31 B 615 ILE GLU PHE ALA ARG LEU GLN PHE THR TYR ASN HIS ILE SEQRES 32 B 615 GLN ARG HIS VAL ASN ASP MET LEU GLY ARG VAL ALA ILE SEQRES 33 B 615 ALA TRP CYS GLU LEU GLN ASN HIS GLU LEU THR LEU TRP SEQRES 34 B 615 ASN GLU ALA ARG LYS LEU ASN PRO ASN ALA ILE ALA SER SEQRES 35 B 615 VAL THR VAL GLY ARG ARG VAL SER ALA ARG MET LEU GLY SEQRES 36 B 615 ASP VAL MET ALA VAL SER THR CYS VAL PRO VAL ALA ALA SEQRES 37 B 615 ASP ASN VAL ILE VAL GLN ASN SER MET ARG ILE SER SER SEQRES 38 B 615 ARG PRO GLY ALA CYS TYR SER ARG PRO LEU VAL SER PHE SEQRES 39 B 615 ARG TYR GLU ASP GLN GLY PRO LEU VAL GLU GLY GLN LEU SEQRES 40 B 615 GLY GLU ASN ASN GLU LEU ARG LEU THR ARG ASP ALA ILE SEQRES 41 B 615 GLU PRO CYS THR VAL GLY HIS ARG ARG TYR PHE THR PHE SEQRES 42 B 615 GLY GLY GLY TYR VAL TYR PHE GLU GLU TYR ALA TYR SER SEQRES 43 B 615 HIS GLN LEU SER ARG ALA ASP ILE THR THR VAL SER THR SEQRES 44 B 615 PHE ILE ASP LEU ASN ILE THR MET LEU GLU ASP HIS GLU SEQRES 45 B 615 PHE VAL PRO LEU GLU VAL TYR THR ARG HIS GLU ILE LYS SEQRES 46 B 615 ASP SER GLY LEU LEU ASP TYR THR GLU VAL GLN ARG ARG SEQRES 47 B 615 ASN GLN LEU HIS ASP LEU ARG PHE ALA ASP ILE ASP THR SEQRES 48 B 615 VAL ILE HIS ALA SEQRES 1 E 230 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY VAL VAL ARG SEQRES 2 E 230 PRO GLY ARG SER LEU ARG LEU SER CYS THR THR SER GLY SEQRES 3 E 230 PHE SER PHE SER GLY SER ALA MET HIS TRP VAL ARG GLN SEQRES 4 E 230 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER SEQRES 5 E 230 HIS ASP GLY ASN ILE ILE GLN TYR HIS ASP SER VAL LYS SEQRES 6 E 230 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN VAL SEQRES 7 E 230 LEU LEU LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR SEQRES 8 E 230 ALA MET TYR TYR CYS ALA ARG ASP VAL TRP LEU LEU PRO SEQRES 9 E 230 ALA THR ILE SER TYR ALA PHE ASP PHE TRP GLY GLN GLY SEQRES 10 E 230 THR MET VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 E 230 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 E 230 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 E 230 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 E 230 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 E 230 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 E 230 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 E 230 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG SEQRES 18 E 230 VAL GLY SER HIS HIS HIS HIS HIS HIS SEQRES 1 G 214 VAL ILE TRP MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 G 214 SER ILE GLY ASP THR VAL THR ILE THR CYS ARG ALA SER SEQRES 3 G 214 GLN GLY ILE SER ASN SER ILE ALA TRP TYR GLN ARG ARG SEQRES 4 G 214 PRO GLY LYS ALA PRO GLU LEU LEU VAL TYR ALA ALA TYR SEQRES 5 G 214 ARG LEU GLN SER GLY VAL PRO SER ARG LEU SER GLY SER SEQRES 6 G 214 GLY SER GLY ALA GLU TYR THR LEU THR ILE LYS ASN MET SEQRES 7 G 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 G 214 TYR ASP ASN PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 G 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 G 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 G 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 G 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 G 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 G 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 G 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 G 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 G 214 PHE ASN ARG GLY GLU CYS SEQRES 1 C 615 ALA ASN PHE TYR VAL CYS PRO PRO PRO THR GLY ALA THR SEQRES 2 C 615 VAL VAL GLN PHE GLU GLN PRO ARG ARG CYS PRO THR ARG SEQRES 3 C 615 PRO GLU GLY GLN ASN TYR THR GLU GLY ILE ALA VAL VAL SEQRES 4 C 615 PHE LYS GLU ASN ILE ALA PRO TYR LYS PHE LYS ALA THR SEQRES 5 C 615 MET TYR TYR LYS ASP VAL THR VAL SER GLN VAL TRP PHE SEQRES 6 C 615 GLY HIS ARG TYR SER GLN PHE MET GLY ILE PHE GLU ASP SEQRES 7 C 615 ARG ALA PRO VAL PRO PHE GLU GLU VAL ILE ASP LYS ILE SEQRES 8 C 615 ASN ALA LYS GLY VAL CYS ARG SER THR ALA LYS TYR VAL SEQRES 9 C 615 ARG ASN ASN LEU GLU THR THR ALA PHE HIS ARG ASP ASP SEQRES 10 C 615 HIS GLU THR ASP MET GLU LEU LYS PRO ALA ASN ALA ALA SEQRES 11 C 615 THR ARG THR SER ARG GLY TRP HIS THR THR ASP LEU LYS SEQRES 12 C 615 TYR ASN PRO SER ARG VAL GLU ALA PHE HIS ARG TYR GLY SEQRES 13 C 615 THR THR VAL ASN CYS ILE VAL GLU GLU VAL ASP ALA ARG SEQRES 14 C 615 SER VAL TYR PRO TYR ASP GLU PHE VAL LEU ALA THR GLY SEQRES 15 C 615 ASP PHE VAL TYR MET SER PRO PHE TYR GLY TYR ARG GLU SEQRES 16 C 615 GLY SER HIS THR GLU HIS THR THR TYR ALA ALA ASP ARG SEQRES 17 C 615 PHE LYS GLN VAL ASP GLY PHE TYR ALA ARG ASP LEU THR SEQRES 18 C 615 THR LYS ALA ARG ALA THR ALA PRO THR THR ARG ASN LEU SEQRES 19 C 615 LEU THR THR PRO LYS PHE THR VAL ALA TRP ASP TRP VAL SEQRES 20 C 615 PRO LYS ARG PRO SER VAL CYS THR MET THR LYS TRP GLN SEQRES 21 C 615 GLU VAL ASP GLU MET LEU ARG SER GLU TYR GLY GLY SER SEQRES 22 C 615 PHE ARG PHE SER SER ASP ALA ILE SER THR THR PHE THR SEQRES 23 C 615 THR ASN LEU THR GLU TYR PRO LEU SER ARG VAL ASP LEU SEQRES 24 C 615 GLY ASP CYS ILE GLY LYS ASP ALA ARG ASP ALA MET ASP SEQRES 25 C 615 ARG ILE PHE ALA ARG ARG TYR ASN ALA THR HIS ILE LYS SEQRES 26 C 615 VAL GLY GLN PRO GLN TYR TYR GLN ALA ASN GLY GLY PHE SEQRES 27 C 615 LEU ILE ALA TYR GLN PRO LEU LEU SER ASN THR LEU ALA SEQRES 28 C 615 GLU LEU TYR VAL ARG GLU HIS LEU ARG GLU GLN SER ARG SEQRES 29 C 615 LYS PRO PRO ASN PRO THR PRO PRO PRO PRO GLY ALA SER SEQRES 30 C 615 ALA ASN ALA SER VAL GLU ARG ILE LYS THR THR SER SER SEQRES 31 C 615 ILE GLU PHE ALA ARG LEU GLN PHE THR TYR ASN HIS ILE SEQRES 32 C 615 GLN ARG HIS VAL ASN ASP MET LEU GLY ARG VAL ALA ILE SEQRES 33 C 615 ALA TRP CYS GLU LEU GLN ASN HIS GLU LEU THR LEU TRP SEQRES 34 C 615 ASN GLU ALA ARG LYS LEU ASN PRO ASN ALA ILE ALA SER SEQRES 35 C 615 VAL THR VAL GLY ARG ARG VAL SER ALA ARG MET LEU GLY SEQRES 36 C 615 ASP VAL MET ALA VAL SER THR CYS VAL PRO VAL ALA ALA SEQRES 37 C 615 ASP ASN VAL ILE VAL GLN ASN SER MET ARG ILE SER SER SEQRES 38 C 615 ARG PRO GLY ALA CYS TYR SER ARG PRO LEU VAL SER PHE SEQRES 39 C 615 ARG TYR GLU ASP GLN GLY PRO LEU VAL GLU GLY GLN LEU SEQRES 40 C 615 GLY GLU ASN ASN GLU LEU ARG LEU THR ARG ASP ALA ILE SEQRES 41 C 615 GLU PRO CYS THR VAL GLY HIS ARG ARG TYR PHE THR PHE SEQRES 42 C 615 GLY GLY GLY TYR VAL TYR PHE GLU GLU TYR ALA TYR SER SEQRES 43 C 615 HIS GLN LEU SER ARG ALA ASP ILE THR THR VAL SER THR SEQRES 44 C 615 PHE ILE ASP LEU ASN ILE THR MET LEU GLU ASP HIS GLU SEQRES 45 C 615 PHE VAL PRO LEU GLU VAL TYR THR ARG HIS GLU ILE LYS SEQRES 46 C 615 ASP SER GLY LEU LEU ASP TYR THR GLU VAL GLN ARG ARG SEQRES 47 C 615 ASN GLN LEU HIS ASP LEU ARG PHE ALA ASP ILE ASP THR SEQRES 48 C 615 VAL ILE HIS ALA HELIX 1 AA1 ARG H 87 THR H 91 5 5 HELIX 2 AA2 GLN L 79 PHE L 83 5 5 HELIX 3 AA3 PRO A 193 LYS A 200 1 8 HELIX 4 AA4 PHE A 223 ASP A 227 5 5 HELIX 5 AA5 TYR A 303 GLU A 310 5 8 HELIX 6 AA6 ALA A 315 ASP A 317 5 3 HELIX 7 AA7 PRO A 358 VAL A 363 1 6 HELIX 8 AA8 PRO A 403 VAL A 407 5 5 HELIX 9 AA9 GLY A 410 TYR A 429 1 20 HELIX 10 AB1 ILE A 501 ASN A 546 1 46 HELIX 11 AB2 ASN A 546 GLY A 556 1 11 HELIX 12 AB3 SER A 660 ILE A 664 5 5 HELIX 13 AB4 THR A 690 GLY A 698 1 9 HELIX 14 AB5 ASP A 701 ALA A 717 1 17 HELIX 15 AB6 ARG D 87 THR D 91 5 5 HELIX 16 AB7 GLN F 79 PHE F 83 5 5 HELIX 17 AB8 PRO B 193 LYS B 200 1 8 HELIX 18 AB9 ARG B 225 ASP B 227 5 3 HELIX 19 AC1 TYR B 303 GLU B 310 5 8 HELIX 20 AC2 ALA B 315 ASP B 317 5 3 HELIX 21 AC3 PRO B 358 VAL B 363 1 6 HELIX 22 AC4 PRO B 403 VAL B 407 5 5 HELIX 23 AC5 GLY B 410 TYR B 429 1 20 HELIX 24 AC6 ILE B 501 ASN B 546 1 46 HELIX 25 AC7 ASN B 546 GLY B 556 1 11 HELIX 26 AC8 SER B 660 ILE B 664 5 5 HELIX 27 AC9 THR B 690 SER B 697 1 8 HELIX 28 AD1 ASP B 701 ALA B 717 1 17 HELIX 29 AD2 ASP E 62 LYS E 65 5 4 HELIX 30 AD3 ARG E 87 THR E 91 5 5 HELIX 31 AD4 GLN G 79 PHE G 83 5 5 HELIX 32 AD5 PRO C 193 LYS C 200 1 8 HELIX 33 AD6 PHE C 223 ASP C 227 5 5 HELIX 34 AD7 TYR C 303 GLU C 310 5 8 HELIX 35 AD8 PRO C 358 VAL C 363 1 6 HELIX 36 AD9 PRO C 403 VAL C 407 5 5 HELIX 37 AE1 GLY C 410 TYR C 429 1 20 HELIX 38 AE2 ILE C 501 ASN C 546 1 46 HELIX 39 AE3 ASN C 546 GLY C 556 1 11 HELIX 40 AE4 ALA C 662 ILE C 664 5 3 HELIX 41 AE5 THR C 690 GLY C 698 1 9 HELIX 42 AE6 ASP C 701 ALA C 717 1 17 SHEET 1 AA1 4 LEU H 4 THR H 7 0 SHEET 2 AA1 4 LEU H 18 THR H 24 -1 O THR H 23 N VAL H 5 SHEET 3 AA1 4 VAL H 78 MET H 83 -1 O LEU H 81 N LEU H 20 SHEET 4 AA1 4 PHE H 68 ASP H 73 -1 N THR H 69 O GLN H 82 SHEET 1 AA2 3 VAL H 11 VAL H 12 0 SHEET 2 AA2 3 MET H 119 VAL H 122 1 O THR H 121 N VAL H 12 SHEET 3 AA2 3 ALA H 92 MET H 93 -1 N ALA H 92 O VAL H 120 SHEET 1 AA3 3 MET H 34 GLN H 39 0 SHEET 2 AA3 3 LEU H 45 ILE H 51 -1 O ILE H 51 N MET H 34 SHEET 3 AA3 3 ILE H 58 TYR H 60 -1 O GLN H 59 N VAL H 50 SHEET 1 AA4 2 ARG H 98 ASP H 99 0 SHEET 2 AA4 2 PHE H 111 PHE H 113 -1 O PHE H 113 N ARG H 98 SHEET 1 AA5 4 MET L 4 SER L 7 0 SHEET 2 AA5 4 VAL L 19 ALA L 25 -1 O THR L 22 N SER L 7 SHEET 3 AA5 4 GLU L 70 ILE L 75 -1 O ILE L 75 N VAL L 19 SHEET 4 AA5 4 LEU L 62 GLY L 64 -1 N SER L 63 O THR L 74 SHEET 1 AA6 2 SER L 10 LEU L 11 0 SHEET 2 AA6 2 LYS L 103 VAL L 104 1 O LYS L 103 N LEU L 11 SHEET 1 AA7 4 ARG L 53 LEU L 54 0 SHEET 2 AA7 4 GLU L 45 TYR L 49 -1 N TYR L 49 O ARG L 53 SHEET 3 AA7 4 ILE L 33 ARG L 38 -1 N TRP L 35 O VAL L 48 SHEET 4 AA7 4 THR L 85 GLN L 90 -1 O TYR L 87 N TYR L 36 SHEET 1 AA8 6 VAL A 574 VAL A 576 0 SHEET 2 AA8 6 PHE A 113 VAL A 115 -1 N VAL A 115 O VAL A 574 SHEET 3 AA8 6 GLU A 622 ARG A 624 1 O LEU A 623 N TYR A 114 SHEET 4 AA8 6 LEU A 612 LEU A 617 -1 N GLN A 616 O ARG A 624 SHEET 5 AA8 6 LEU A 601 ARG A 605 -1 N PHE A 604 O VAL A 613 SHEET 6 AA8 6 VAL A 581 VAL A 583 -1 N ILE A 582 O SER A 603 SHEET 1 AA9 4 VAL A 559 ALA A 561 0 SHEET 2 AA9 4 MET A 568 THR A 572 -1 O SER A 571 N SER A 560 SHEET 3 AA9 4 THR A 123 PHE A 127 -1 N VAL A 125 O MET A 568 SHEET 4 AA9 4 THR C 665 VAL C 667 1 O VAL C 667 N GLN A 126 SHEET 1 AB1 5 GLY A 145 GLU A 152 0 SHEET 2 AB1 5 MET A 366 VAL A 372 -1 O THR A 367 N LYS A 151 SHEET 3 AB1 5 HIS A 433 LYS A 435 0 SHEET 4 AB1 5 GLN A 440 ALA A 444 0 SHEET 5 AB1 5 PHE A 448 SER A 457 -1 O TYR A 452 N GLN A 440 SHEET 1 AB210 TYR A 157 PHE A 175 0 SHEET 2 AB210 SER A 180 PRO A 191 -1 O GLN A 181 N TRP A 174 SHEET 3 AB210 LYS A 235 PRO A 236 0 SHEET 4 AB210 GLY A 246 HIS A 248 -1 O HIS A 248 N LYS A 235 SHEET 5 AB210 PHE A 262 GLY A 266 -1 O GLY A 266 N SER A 171 SHEET 6 AB210 CYS A 271 SER A 280 -1 O VAL A 273 N TRP A 247 SHEET 7 AB210 PHE A 287 VAL A 288 -1 O VAL A 288 N ARG A 279 SHEET 8 AB210 PHE A 319 PHE A 325 0 SHEET 9 AB210 THR A 340 LEU A 345 -1 O THR A 340 N PHE A 325 SHEET 10 AB210 VAL A 352 TRP A 354 -1 O TRP A 354 N ASN A 343 SHEET 1 AB3 2 VAL A 206 ARG A 208 0 SHEET 2 AB3 2 ASP A 231 GLU A 233 -1 O MET A 232 N CYS A 207 SHEET 1 AB4 2 TYR A 213 VAL A 214 0 SHEET 2 AB4 2 GLU A 219 THR A 220 -1 O THR A 220 N TYR A 213 SHEET 1 AB5 2 PHE A 384 SER A 388 0 SHEET 2 AB5 2 THR A 393 THR A 397 -1 O THR A 397 N PHE A 384 SHEET 1 AB6 2 ALA A 595 TYR A 597 0 SHEET 2 AB6 2 ILE A 630 PRO A 632 -1 O GLU A 631 N CYS A 596 SHEET 1 AB7 3 ARG A 638 PHE A 643 0 SHEET 2 AB7 3 GLY A 646 GLU A 651 -1 O GLY A 646 N PHE A 643 SHEET 3 AB7 3 TYR A 655 LEU A 659 -1 O SER A 656 N TYR A 649 SHEET 1 AB8 4 THR A 665 VAL A 667 0 SHEET 2 AB8 4 THR B 123 PHE B 127 1 O GLN B 126 N VAL A 667 SHEET 3 AB8 4 MET B 568 THR B 572 -1 O MET B 568 N VAL B 125 SHEET 4 AB8 4 VAL B 559 MET B 563 -1 N ARG B 562 O ALA B 569 SHEET 1 AB9 4 GLN D 3 THR D 7 0 SHEET 2 AB9 4 SER D 17 SER D 25 -1 O THR D 23 N VAL D 5 SHEET 3 AB9 4 VAL D 78 ASN D 84 -1 O LEU D 81 N LEU D 20 SHEET 4 AB9 4 PHE D 68 ASP D 73 -1 N SER D 71 O LEU D 80 SHEET 1 AC1 6 VAL D 11 VAL D 12 0 SHEET 2 AC1 6 MET D 119 VAL D 122 1 O THR D 121 N VAL D 12 SHEET 3 AC1 6 ALA D 92 TYR D 95 -1 N ALA D 92 O VAL D 120 SHEET 4 AC1 6 MET D 34 GLN D 39 -1 N VAL D 37 O TYR D 95 SHEET 5 AC1 6 LEU D 45 ILE D 51 -1 O ALA D 49 N TRP D 36 SHEET 6 AC1 6 ILE D 58 TYR D 60 -1 O GLN D 59 N VAL D 50 SHEET 1 AC2 2 ARG D 98 ASP D 99 0 SHEET 2 AC2 2 PHE D 111 PHE D 113 -1 O PHE D 113 N ARG D 98 SHEET 1 AC3 4 MET F 4 SER F 7 0 SHEET 2 AC3 4 VAL F 19 ALA F 25 -1 O THR F 22 N SER F 7 SHEET 3 AC3 4 GLU F 70 ILE F 75 -1 O ILE F 75 N VAL F 19 SHEET 4 AC3 4 SER F 63 SER F 67 -1 N SER F 63 O THR F 74 SHEET 1 AC4 2 SER F 10 LEU F 11 0 SHEET 2 AC4 2 LYS F 103 VAL F 104 1 O LYS F 103 N LEU F 11 SHEET 1 AC5 4 ARG F 53 LEU F 54 0 SHEET 2 AC5 4 GLU F 45 TYR F 49 -1 N TYR F 49 O ARG F 53 SHEET 3 AC5 4 ILE F 33 ARG F 38 -1 N TRP F 35 O LEU F 47 SHEET 4 AC5 4 THR F 85 GLN F 90 -1 O TYR F 87 N TYR F 36 SHEET 1 AC6 6 VAL B 574 VAL B 576 0 SHEET 2 AC6 6 PHE B 113 VAL B 115 -1 N VAL B 115 O VAL B 574 SHEET 3 AC6 6 GLU B 622 ARG B 624 1 O LEU B 623 N TYR B 114 SHEET 4 AC6 6 LEU B 612 LEU B 617 -1 N GLN B 616 O ARG B 624 SHEET 5 AC6 6 LEU B 601 ARG B 605 -1 N PHE B 604 O VAL B 613 SHEET 6 AC6 6 VAL B 581 VAL B 583 -1 N ILE B 582 O SER B 603 SHEET 1 AC7 5 GLY B 145 GLU B 152 0 SHEET 2 AC7 5 MET B 366 VAL B 372 -1 O THR B 367 N LYS B 151 SHEET 3 AC7 5 HIS B 433 LYS B 435 0 SHEET 4 AC7 5 GLN B 440 ALA B 444 0 SHEET 5 AC7 5 PHE B 448 SER B 457 -1 O TYR B 452 N GLN B 440 SHEET 1 AC8 9 TYR B 157 LYS B 166 0 SHEET 2 AC8 9 ALA B 190 PRO B 191 -1 O ALA B 190 N LYS B 166 SHEET 3 AC8 9 LYS B 235 PRO B 236 0 SHEET 4 AC8 9 GLY B 246 HIS B 248 -1 O HIS B 248 N LYS B 235 SHEET 5 AC8 9 CYS B 271 SER B 280 -1 O VAL B 273 N TRP B 247 SHEET 6 AC8 9 PHE B 287 VAL B 288 -1 O VAL B 288 N ARG B 279 SHEET 7 AC8 9 PHE B 319 PHE B 325 0 SHEET 8 AC8 9 THR B 340 THR B 346 -1 O THR B 340 N PHE B 325 SHEET 9 AC8 9 THR B 351 TRP B 354 -1 O TRP B 354 N ASN B 343 SHEET 1 AC9 3 SER B 180 GLU B 187 0 SHEET 2 AC9 3 THR B 169 PHE B 175 -1 N TRP B 174 O GLN B 181 SHEET 3 AC9 3 HIS B 263 THR B 268 -1 O GLY B 266 N SER B 171 SHEET 1 AD1 2 VAL B 206 ARG B 208 0 SHEET 2 AD1 2 ASP B 231 GLU B 233 -1 O MET B 232 N CYS B 207 SHEET 1 AD2 2 THR B 210 ARG B 215 0 SHEET 2 AD2 2 LEU B 218 PHE B 223 -1 O THR B 220 N TYR B 213 SHEET 1 AD3 2 SER B 383 SER B 388 0 SHEET 2 AD3 2 THR B 393 ASN B 398 -1 O THR B 397 N PHE B 384 SHEET 1 AD4 2 ALA B 595 TYR B 597 0 SHEET 2 AD4 2 ILE B 630 PRO B 632 -1 O GLU B 631 N CYS B 596 SHEET 1 AD5 3 ARG B 638 PHE B 643 0 SHEET 2 AD5 3 GLY B 646 GLU B 651 -1 O GLY B 646 N PHE B 643 SHEET 3 AD5 3 TYR B 655 LEU B 659 -1 O LEU B 659 N TYR B 647 SHEET 1 AD6 4 THR B 665 VAL B 667 0 SHEET 2 AD6 4 THR C 123 PHE C 127 1 O GLN C 126 N VAL B 667 SHEET 3 AD6 4 MET C 568 THR C 572 -1 O MET C 568 N VAL C 125 SHEET 4 AD6 4 VAL C 559 MET C 563 -1 N ARG C 562 O ALA C 569 SHEET 1 AD7 4 GLN E 3 THR E 7 0 SHEET 2 AD7 4 LEU E 18 SER E 25 -1 O THR E 23 N VAL E 5 SHEET 3 AD7 4 VAL E 78 MET E 83 -1 O LEU E 81 N LEU E 20 SHEET 4 AD7 4 PHE E 68 ASP E 73 -1 N THR E 69 O GLN E 82 SHEET 1 AD8 5 ILE E 58 TYR E 60 0 SHEET 2 AD8 5 LEU E 45 ILE E 51 -1 N VAL E 50 O GLN E 59 SHEET 3 AD8 5 MET E 34 GLN E 39 -1 N MET E 34 O ILE E 51 SHEET 4 AD8 5 ALA E 92 TYR E 95 -1 O TYR E 95 N VAL E 37 SHEET 5 AD8 5 MET E 119 VAL E 120 -1 O VAL E 120 N ALA E 92 SHEET 1 AD9 2 ARG E 98 ASP E 99 0 SHEET 2 AD9 2 PHE E 111 PHE E 113 -1 O PHE E 113 N ARG E 98 SHEET 1 AE1 4 MET G 4 SER G 7 0 SHEET 2 AE1 4 VAL G 19 ALA G 25 -1 O THR G 22 N SER G 7 SHEET 3 AE1 4 GLU G 70 ILE G 75 -1 O TYR G 71 N CYS G 23 SHEET 4 AE1 4 LEU G 62 GLY G 64 -1 N SER G 63 O THR G 74 SHEET 1 AE2 2 SER G 10 LEU G 11 0 SHEET 2 AE2 2 LYS G 103 VAL G 104 1 O LYS G 103 N LEU G 11 SHEET 1 AE3 4 ARG G 53 LEU G 54 0 SHEET 2 AE3 4 GLU G 45 TYR G 49 -1 N TYR G 49 O ARG G 53 SHEET 3 AE3 4 ILE G 33 ARG G 38 -1 N GLN G 37 O GLU G 45 SHEET 4 AE3 4 THR G 85 GLN G 90 -1 O TYR G 87 N TYR G 36 SHEET 1 AE4 6 VAL C 574 VAL C 576 0 SHEET 2 AE4 6 PHE C 113 VAL C 115 -1 N VAL C 115 O VAL C 574 SHEET 3 AE4 6 GLU C 622 ARG C 624 1 O LEU C 623 N TYR C 114 SHEET 4 AE4 6 LEU C 612 LEU C 617 -1 N GLN C 616 O ARG C 624 SHEET 5 AE4 6 LEU C 601 ARG C 605 -1 N PHE C 604 O VAL C 613 SHEET 6 AE4 6 VAL C 581 VAL C 583 -1 N ILE C 582 O SER C 603 SHEET 1 AE5 2 TYR C 142 THR C 143 0 SHEET 2 AE5 2 ARG C 377 SER C 378 -1 O ARG C 377 N THR C 143 SHEET 1 AE6 5 GLY C 145 GLU C 152 0 SHEET 2 AE6 5 MET C 366 VAL C 372 -1 O THR C 367 N LYS C 151 SHEET 3 AE6 5 HIS C 433 LYS C 435 0 SHEET 4 AE6 5 GLN C 440 GLN C 443 0 SHEET 5 AE6 5 LEU C 449 SER C 457 -1 O TYR C 452 N GLN C 440 SHEET 1 AE7 8 TYR C 157 LYS C 166 0 SHEET 2 AE7 8 ALA C 190 PRO C 191 -1 O ALA C 190 N LYS C 166 SHEET 3 AE7 8 LYS C 235 PRO C 236 0 SHEET 4 AE7 8 GLY C 246 HIS C 248 -1 O HIS C 248 N LYS C 235 SHEET 5 AE7 8 CYS C 271 SER C 280 -1 O VAL C 273 N TRP C 247 SHEET 6 AE7 8 PHE C 287 VAL C 288 -1 O VAL C 288 N ARG C 279 SHEET 7 AE7 8 PHE C 294 VAL C 295 -1 O VAL C 295 N PHE C 287 SHEET 8 AE7 8 VAL C 352 ALA C 353 -1 O ALA C 353 N THR C 162 SHEET 1 AE8 3 SER C 180 GLU C 187 0 SHEET 2 AE8 3 THR C 169 PHE C 175 -1 N TRP C 174 O GLN C 181 SHEET 3 AE8 3 PHE C 262 THR C 268 -1 O GLY C 266 N SER C 171 SHEET 1 AE9 2 VAL C 206 ARG C 208 0 SHEET 2 AE9 2 ASP C 231 GLU C 233 -1 O MET C 232 N CYS C 207 SHEET 1 AF1 2 TYR C 213 ARG C 215 0 SHEET 2 AF1 2 LEU C 218 THR C 220 -1 O LEU C 218 N ARG C 215 SHEET 1 AF2 2 GLN C 321 PHE C 325 0 SHEET 2 AF2 2 THR C 340 ASN C 343 -1 O THR C 340 N PHE C 325 SHEET 1 AF3 2 SER C 383 SER C 388 0 SHEET 2 AF3 2 THR C 393 ASN C 398 -1 O PHE C 395 N PHE C 386 SHEET 1 AF4 2 ALA C 595 TYR C 597 0 SHEET 2 AF4 2 ILE C 630 PRO C 632 -1 O GLU C 631 N CYS C 596 SHEET 1 AF5 3 ARG C 638 PHE C 643 0 SHEET 2 AF5 3 GLY C 646 GLU C 651 -1 O GLY C 646 N PHE C 643 SHEET 3 AF5 3 TYR C 655 SER C 660 -1 O LEU C 659 N TYR C 647 CISPEP 1 SER L 7 PRO L 8 0 -2.60 CISPEP 2 ASN L 94 PRO L 95 0 -1.12 CISPEP 3 TYR A 282 PRO A 283 0 5.45 CISPEP 4 SER F 7 PRO F 8 0 -1.46 CISPEP 5 ASN F 94 PRO F 95 0 -1.25 CISPEP 6 TYR B 282 PRO B 283 0 5.34 CISPEP 7 SER G 7 PRO G 8 0 -1.28 CISPEP 8 ASN G 94 PRO G 95 0 -1.63 CISPEP 9 TYR C 282 PRO C 283 0 4.80 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000