HEADER STRUCTURAL PROTEIN 30-SEP-23 8QP6 TITLE CRYSTAL STRUCTURE OF HEPATITIS C VIRUS E1 GLYCOPROTEIN EPITOPE 314-324 TITLE 2 SCAFFOLD DESIGN 1W4K_08 IN COMPLEX WITH NEUTRALIZING ANTIBODY F(AB) TITLE 3 FRAGMENT IGH526 COMPND MOL_ID: 1; COMPND 2 MOLECULE: 1W4K_08; COMPND 3 CHAIN: A, G, D, J; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: F(AB) IGH526; COMPND 7 CHAIN: B, C, E, H, I, F, K, L; COMPND 8 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: PYROBACULUM AEROPHILUM; SOURCE 3 ORGANISM_TAXID: 13773; SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 5 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 6 EXPRESSION_SYSTEM_STRAIN: GOLD; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS SCAFFOLD PROTEIN, HCV IMMUNOGEN, STRUCTURAL PROTEIN, COMPLEX EXPDTA X-RAY DIFFRACTION AUTHOR K.NAGARATHINAM,T.KREY REVDAT 1 09-OCT-24 8QP6 0 JRNL AUTH K.NAGARATHINAM,T.KREY,A.SCHECK,M.LABUHN,L.J.STROEH,E.HEROLD, JRNL AUTH 2 B.VESELKOVA,J.T.CRAMER,S.ROSSET,S.S.VOLLERS,D.BANKWITZ, JRNL AUTH 3 M.BALLMAIER,H.BOENING,E.ROTH,T.KHERA,H.AHSENDORF,S.TUNE, JRNL AUTH 4 O.DITTRICH-BREIHOLZ,J.OBLESER,M.NASSAL,H.M.JAECK, JRNL AUTH 5 T.PIETSCHMANN,B.E.CORREIA JRNL TITL CRYSTAL STRUCTURE OF HEPATITIS C VIRUS E1 GLYCOPROTEIN JRNL TITL 2 EPITOPE 314-324 SCAFFOLD DESIGN 1W4K_08 IN COMPLEX WITH JRNL TITL 3 NEUTRALIZING ANTIBODY F(AB) FRAGMENT IGH526 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.59 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : PHENIX 1.18_3861 REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE, REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER, REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY, REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON, REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI, REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART REMARK 3 REMARK 3 REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2 REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.59 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 48.63 REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.340 REMARK 3 COMPLETENESS FOR RANGE (%) : 99.4 REMARK 3 NUMBER OF REFLECTIONS : 64595 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 R VALUE (WORKING + TEST SET) : 0.234 REMARK 3 R VALUE (WORKING SET) : 0.232 REMARK 3 FREE R VALUE : 0.273 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.000 REMARK 3 FREE R VALUE TEST SET COUNT : 3227 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS). REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE REMARK 3 1 48.6300 - 7.3700 0.99 2890 154 0.1991 0.2374 REMARK 3 2 7.3700 - 5.8500 1.00 2765 145 0.2235 0.2406 REMARK 3 3 5.8500 - 5.1100 1.00 2725 144 0.1823 0.2210 REMARK 3 4 5.1100 - 4.6500 1.00 2731 143 0.1650 0.2186 REMARK 3 5 4.6400 - 4.3100 1.00 2682 141 0.1631 0.1958 REMARK 3 6 4.3100 - 4.0600 1.00 2695 142 0.1840 0.2237 REMARK 3 7 4.0600 - 3.8600 1.00 2676 141 0.2156 0.2685 REMARK 3 8 3.8500 - 3.6900 1.00 2686 142 0.2386 0.2886 REMARK 3 9 3.6900 - 3.5500 0.99 2649 140 0.2485 0.2990 REMARK 3 10 3.5500 - 3.4200 1.00 2663 140 0.2490 0.3012 REMARK 3 11 3.4200 - 3.3200 1.00 2644 138 0.2702 0.2989 REMARK 3 12 3.3200 - 3.2200 0.99 2666 142 0.2884 0.3471 REMARK 3 13 3.2200 - 3.1400 0.99 2626 136 0.3107 0.3341 REMARK 3 14 3.1400 - 3.0600 0.99 2668 140 0.3054 0.3672 REMARK 3 15 3.0600 - 2.9900 0.99 2621 137 0.3059 0.3485 REMARK 3 16 2.9900 - 2.9300 1.00 2658 140 0.3206 0.3648 REMARK 3 17 2.9300 - 2.8700 1.00 2639 139 0.3170 0.4234 REMARK 3 18 2.8700 - 2.8100 1.00 2655 140 0.3300 0.3863 REMARK 3 19 2.8100 - 2.7600 1.00 2622 138 0.3412 0.4008 REMARK 3 20 2.7600 - 2.7200 1.00 2660 140 0.3835 0.4395 REMARK 3 21 2.7200 - 2.6700 0.99 2605 136 0.3850 0.4126 REMARK 3 22 2.6700 - 2.6300 0.99 2658 141 0.4227 0.4398 REMARK 3 23 2.6300 - 2.5900 0.95 2484 128 0.4564 0.4789 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL REMARK 3 SOLVENT RADIUS : 1.11 REMARK 3 SHRINKAGE RADIUS : 0.90 REMARK 3 K_SOL : NULL REMARK 3 B_SOL : NULL REMARK 3 REMARK 3 ERROR ESTIMATES. REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.510 REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 37.765 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : 70.17 REMARK 3 MEAN B VALUE (OVERALL, A**2) : 77.91 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : NULL REMARK 3 B22 (A**2) : NULL REMARK 3 B33 (A**2) : NULL REMARK 3 B12 (A**2) : NULL REMARK 3 B13 (A**2) : NULL REMARK 3 B23 (A**2) : NULL REMARK 3 REMARK 3 TWINNING INFORMATION. REMARK 3 FRACTION: NULL REMARK 3 OPERATOR: NULL REMARK 3 REMARK 3 DEVIATIONS FROM IDEAL VALUES. REMARK 3 RMSD COUNT REMARK 3 BOND : 0.002 13528 REMARK 3 ANGLE : 0.583 18513 REMARK 3 CHIRALITY : 0.043 2150 REMARK 3 PLANARITY : 0.005 2364 REMARK 3 DIHEDRAL : 12.502 1898 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : 53 REMARK 3 TLS GROUP : 1 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 5 THROUGH 19 ) REMARK 3 ORIGIN FOR THE GROUP (A): -22.0738 -27.4231 -59.0183 REMARK 3 T TENSOR REMARK 3 T11: 0.7613 T22: 0.7106 REMARK 3 T33: 0.7124 T12: -0.2107 REMARK 3 T13: 0.0604 T23: -0.0139 REMARK 3 L TENSOR REMARK 3 L11: 2.0737 L22: 3.0769 REMARK 3 L33: 5.5211 L12: 0.5487 REMARK 3 L13: -0.9131 L23: 3.6609 REMARK 3 S TENSOR REMARK 3 S11: -1.1743 S12: 0.3331 S13: -1.0103 REMARK 3 S21: -0.2975 S22: 0.5143 S23: -0.4652 REMARK 3 S31: 2.5508 S32: 0.3368 S33: -1.1167 REMARK 3 TLS GROUP : 2 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 20 THROUGH 36 ) REMARK 3 ORIGIN FOR THE GROUP (A): -26.3372 -34.7369 -54.0248 REMARK 3 T TENSOR REMARK 3 T11: 1.6660 T22: 0.1039 REMARK 3 T33: 0.9337 T12: -0.2932 REMARK 3 T13: 0.3457 T23: -0.4023 REMARK 3 L TENSOR REMARK 3 L11: 0.6370 L22: 0.3449 REMARK 3 L33: 3.0312 L12: -0.3796 REMARK 3 L13: 0.7965 L23: -0.9425 REMARK 3 S TENSOR REMARK 3 S11: 0.5260 S12: 0.4230 S13: -0.7592 REMARK 3 S21: -0.5973 S22: 0.9670 S23: -1.0605 REMARK 3 S31: 0.4511 S32: 0.0569 S33: 4.3415 REMARK 3 TLS GROUP : 3 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 37 THROUGH 44 ) REMARK 3 ORIGIN FOR THE GROUP (A): -24.7861 -39.7289 -45.4716 REMARK 3 T TENSOR REMARK 3 T11: 2.5958 T22: 1.4667 REMARK 3 T33: 1.3105 T12: 0.1079 REMARK 3 T13: -0.2742 T23: -0.0240 REMARK 3 L TENSOR REMARK 3 L11: 6.5313 L22: 3.0920 REMARK 3 L33: 5.3938 L12: -2.8097 REMARK 3 L13: -5.4254 L23: 3.6256 REMARK 3 S TENSOR REMARK 3 S11: -0.5182 S12: 2.5775 S13: -2.0510 REMARK 3 S21: -1.3288 S22: -1.6754 S23: -2.1960 REMARK 3 S31: 1.5789 S32: -0.5214 S33: -0.2494 REMARK 3 TLS GROUP : 4 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 2 THROUGH 18 ) REMARK 3 ORIGIN FOR THE GROUP (A): -10.0767 -15.6157 -80.7736 REMARK 3 T TENSOR REMARK 3 T11: 0.7702 T22: 0.8457 REMARK 3 T33: 0.8111 T12: -0.0385 REMARK 3 T13: 0.0948 T23: -0.0262 REMARK 3 L TENSOR REMARK 3 L11: 0.1988 L22: 0.6310 REMARK 3 L33: 0.2577 L12: 0.0488 REMARK 3 L13: 0.3780 L23: 0.1943 REMARK 3 S TENSOR REMARK 3 S11: 0.3547 S12: -0.2010 S13: 0.0257 REMARK 3 S21: -0.6306 S22: -0.5004 S23: 0.0841 REMARK 3 S31: 1.5677 S32: -0.1629 S33: 0.0001 REMARK 3 TLS GROUP : 5 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 19 THROUGH 40 ) REMARK 3 ORIGIN FOR THE GROUP (A): -9.9987 -21.1799 -70.7503 REMARK 3 T TENSOR REMARK 3 T11: 0.6074 T22: 0.8233 REMARK 3 T33: 0.6391 T12: -0.0257 REMARK 3 T13: 0.0325 T23: -0.0039 REMARK 3 L TENSOR REMARK 3 L11: 0.2781 L22: 0.6662 REMARK 3 L33: 1.2952 L12: -0.4722 REMARK 3 L13: -0.4396 L23: 0.1013 REMARK 3 S TENSOR REMARK 3 S11: -0.3571 S12: -0.6378 S13: -0.1249 REMARK 3 S21: -0.0068 S22: 0.3514 S23: -0.4110 REMARK 3 S31: 0.3389 S32: 1.1110 S33: 0.0036 REMARK 3 TLS GROUP : 6 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 41 THROUGH 65 ) REMARK 3 ORIGIN FOR THE GROUP (A): -20.8419 -20.4361 -71.2302 REMARK 3 T TENSOR REMARK 3 T11: 0.9340 T22: 0.6137 REMARK 3 T33: 0.7302 T12: -0.1072 REMARK 3 T13: 0.0590 T23: -0.0702 REMARK 3 L TENSOR REMARK 3 L11: 1.9065 L22: 1.7007 REMARK 3 L33: 1.6402 L12: 0.9987 REMARK 3 L13: -0.1709 L23: 1.3301 REMARK 3 S TENSOR REMARK 3 S11: -0.0754 S12: -0.0680 S13: -0.2637 REMARK 3 S21: -1.0498 S22: 0.4244 S23: 0.4892 REMARK 3 S31: 0.2915 S32: -0.7683 S33: 0.0012 REMARK 3 TLS GROUP : 7 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 66 THROUGH 84 ) REMARK 3 ORIGIN FOR THE GROUP (A): -13.5630 -25.9192 -77.0363 REMARK 3 T TENSOR REMARK 3 T11: 0.9071 T22: 0.7297 REMARK 3 T33: 0.8514 T12: -0.0380 REMARK 3 T13: 0.1595 T23: -0.0615 REMARK 3 L TENSOR REMARK 3 L11: 0.0011 L22: 1.2792 REMARK 3 L33: 1.4771 L12: -0.1327 REMARK 3 L13: 0.1877 L23: -0.7319 REMARK 3 S TENSOR REMARK 3 S11: -0.6416 S12: 0.0255 S13: -0.3462 REMARK 3 S21: -1.4461 S22: 0.2908 S23: -0.1784 REMARK 3 S31: 0.1371 S32: -0.3737 S33: -0.0035 REMARK 3 TLS GROUP : 8 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 85 THROUGH 124 ) REMARK 3 ORIGIN FOR THE GROUP (A): -14.7161 -15.9860 -69.0727 REMARK 3 T TENSOR REMARK 3 T11: 0.8406 T22: 0.6182 REMARK 3 T33: 0.7309 T12: -0.0125 REMARK 3 T13: 0.1081 T23: -0.0508 REMARK 3 L TENSOR REMARK 3 L11: 1.3187 L22: 1.4823 REMARK 3 L33: 0.6668 L12: -0.0376 REMARK 3 L13: -0.6696 L23: 0.6617 REMARK 3 S TENSOR REMARK 3 S11: 0.0691 S12: 0.2624 S13: -0.1019 REMARK 3 S21: -0.2022 S22: -0.0405 S23: 0.0963 REMARK 3 S31: -0.2722 S32: 0.6369 S33: 0.0002 REMARK 3 TLS GROUP : 9 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 125 THROUGH 147 ) REMARK 3 ORIGIN FOR THE GROUP (A): -11.4979 5.5876 -97.8795 REMARK 3 T TENSOR REMARK 3 T11: 0.6673 T22: 1.0864 REMARK 3 T33: 0.6681 T12: 0.1009 REMARK 3 T13: 0.0591 T23: -0.1172 REMARK 3 L TENSOR REMARK 3 L11: 0.7197 L22: 0.4809 REMARK 3 L33: 1.5923 L12: -0.0287 REMARK 3 L13: 1.0801 L23: -0.2646 REMARK 3 S TENSOR REMARK 3 S11: 0.0067 S12: -0.3631 S13: 0.2658 REMARK 3 S21: -0.4941 S22: 0.0517 S23: 0.0954 REMARK 3 S31: -0.6121 S32: -0.7211 S33: -0.0070 REMARK 3 TLS GROUP : 10 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 148 THROUGH 216 ) REMARK 3 ORIGIN FOR THE GROUP (A): -4.9731 9.7904 -92.3311 REMARK 3 T TENSOR REMARK 3 T11: 0.7199 T22: 0.5929 REMARK 3 T33: 0.6529 T12: -0.0357 REMARK 3 T13: 0.0323 T23: -0.0455 REMARK 3 L TENSOR REMARK 3 L11: 3.5692 L22: 1.7798 REMARK 3 L33: 6.6640 L12: -0.8635 REMARK 3 L13: -1.1110 L23: 0.0949 REMARK 3 S TENSOR REMARK 3 S11: 0.0514 S12: -0.3284 S13: 0.0612 REMARK 3 S21: 0.0782 S22: -0.1252 S23: -0.1186 REMARK 3 S31: -0.4627 S32: 0.5135 S33: 0.0001 REMARK 3 TLS GROUP : 11 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 217 THROUGH 228 ) REMARK 3 ORIGIN FOR THE GROUP (A): -2.3994 11.3655-101.0574 REMARK 3 T TENSOR REMARK 3 T11: 0.4155 T22: 0.7885 REMARK 3 T33: 0.5391 T12: 0.0552 REMARK 3 T13: 0.3578 T23: -0.0619 REMARK 3 L TENSOR REMARK 3 L11: 2.6297 L22: 4.7182 REMARK 3 L33: 6.6201 L12: -2.5573 REMARK 3 L13: 2.9740 L23: -4.2725 REMARK 3 S TENSOR REMARK 3 S11: -0.7737 S12: 0.5254 S13: 0.9994 REMARK 3 S21: 0.7305 S22: 0.2889 S23: -0.6054 REMARK 3 S31: -1.4710 S32: 0.2651 S33: -0.6028 REMARK 3 TLS GROUP : 12 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 5 THROUGH 9 ) REMARK 3 ORIGIN FOR THE GROUP (A): 30.8765 -25.9037 -60.1968 REMARK 3 T TENSOR REMARK 3 T11: 0.9744 T22: 0.9195 REMARK 3 T33: 0.9305 T12: 0.1705 REMARK 3 T13: 0.1505 T23: 0.1369 REMARK 3 L TENSOR REMARK 3 L11: 0.3639 L22: 0.1958 REMARK 3 L33: 0.5779 L12: -0.2410 REMARK 3 L13: 0.3926 L23: -0.2303 REMARK 3 S TENSOR REMARK 3 S11: -0.7055 S12: -0.5844 S13: -1.4116 REMARK 3 S21: 0.9877 S22: 0.8071 S23: -0.0778 REMARK 3 S31: 0.4651 S32: 1.4200 S33: 0.0006 REMARK 3 TLS GROUP : 13 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 10 THROUGH 19 ) REMARK 3 ORIGIN FOR THE GROUP (A): 19.6356 -28.0910 -62.6341 REMARK 3 T TENSOR REMARK 3 T11: 1.3277 T22: 0.7264 REMARK 3 T33: 0.6633 T12: -0.2216 REMARK 3 T13: -0.0151 T23: -0.1005 REMARK 3 L TENSOR REMARK 3 L11: 0.9923 L22: 1.1695 REMARK 3 L33: 0.0507 L12: -0.5127 REMARK 3 L13: 0.1585 L23: -0.2443 REMARK 3 S TENSOR REMARK 3 S11: -0.9002 S12: 0.6749 S13: -0.2291 REMARK 3 S21: 2.0639 S22: 0.6492 S23: -0.5877 REMARK 3 S31: 2.4025 S32: -0.2051 S33: -0.0048 REMARK 3 TLS GROUP : 14 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 4 THROUGH 106 ) REMARK 3 ORIGIN FOR THE GROUP (A): -18.1321 -5.2666 -58.3611 REMARK 3 T TENSOR REMARK 3 T11: 0.8777 T22: 0.6438 REMARK 3 T33: 0.6404 T12: -0.0156 REMARK 3 T13: 0.0129 T23: 0.0066 REMARK 3 L TENSOR REMARK 3 L11: 4.6047 L22: 3.6716 REMARK 3 L33: 5.2689 L12: 0.6870 REMARK 3 L13: 0.6539 L23: 0.4348 REMARK 3 S TENSOR REMARK 3 S11: -0.2371 S12: 0.0699 S13: 0.3232 REMARK 3 S21: -0.0555 S22: 0.0996 S23: 0.0525 REMARK 3 S31: -1.0626 S32: 0.0284 S33: 0.0001 REMARK 3 TLS GROUP : 15 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 107 THROUGH 193 ) REMARK 3 ORIGIN FOR THE GROUP (A): -17.4931 15.2940 -86.5659 REMARK 3 T TENSOR REMARK 3 T11: 0.9799 T22: 0.7082 REMARK 3 T33: 0.8342 T12: 0.0975 REMARK 3 T13: 0.0473 T23: -0.0585 REMARK 3 L TENSOR REMARK 3 L11: 1.6178 L22: 2.3143 REMARK 3 L33: 2.8704 L12: 1.2015 REMARK 3 L13: -0.5559 L23: -1.0155 REMARK 3 S TENSOR REMARK 3 S11: 0.3456 S12: 0.2137 S13: 0.0065 REMARK 3 S21: 0.6325 S22: 0.0136 S23: 0.0960 REMARK 3 S31: -0.2092 S32: -0.0688 S33: 0.0003 REMARK 3 TLS GROUP : 16 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 194 THROUGH 216 ) REMARK 3 ORIGIN FOR THE GROUP (A): -21.2945 23.7877 -88.6215 REMARK 3 T TENSOR REMARK 3 T11: 1.2851 T22: 0.6933 REMARK 3 T33: 0.7798 T12: 0.1520 REMARK 3 T13: 0.0236 T23: 0.0240 REMARK 3 L TENSOR REMARK 3 L11: 1.9142 L22: 1.0621 REMARK 3 L33: 0.8643 L12: 0.1354 REMARK 3 L13: 1.3383 L23: -0.0158 REMARK 3 S TENSOR REMARK 3 S11: -0.4048 S12: -0.4019 S13: 0.2913 REMARK 3 S21: 1.3265 S22: -0.6622 S23: 0.9993 REMARK 3 S31: -1.3983 S32: -0.4784 S33: -0.2954 REMARK 3 TLS GROUP : 17 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 5 THROUGH 9 ) REMARK 3 ORIGIN FOR THE GROUP (A): -7.6597 -23.1295 -36.5454 REMARK 3 T TENSOR REMARK 3 T11: 0.6401 T22: 0.4250 REMARK 3 T33: 0.4587 T12: 0.0374 REMARK 3 T13: -0.1880 T23: 0.3233 REMARK 3 L TENSOR REMARK 3 L11: 1.8027 L22: 6.3942 REMARK 3 L33: 4.0568 L12: -2.7036 REMARK 3 L13: -2.3906 L23: 2.1326 REMARK 3 S TENSOR REMARK 3 S11: 0.0084 S12: 0.4029 S13: -0.5237 REMARK 3 S21: -0.5862 S22: -0.1976 S23: 0.6439 REMARK 3 S31: 0.1553 S32: -0.7651 S33: -2.5358 REMARK 3 TLS GROUP : 18 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 10 THROUGH 22 ) REMARK 3 ORIGIN FOR THE GROUP (A): -16.3306 -30.3322 -39.1003 REMARK 3 T TENSOR REMARK 3 T11: 0.2789 T22: 0.5303 REMARK 3 T33: 0.6574 T12: 0.0653 REMARK 3 T13: -0.0849 T23: -0.1277 REMARK 3 L TENSOR REMARK 3 L11: 0.4759 L22: 3.6471 REMARK 3 L33: 8.6955 L12: 1.2440 REMARK 3 L13: -1.8777 L23: -5.6027 REMARK 3 S TENSOR REMARK 3 S11: -0.1562 S12: -0.5616 S13: -0.0617 REMARK 3 S21: -0.7833 S22: 0.1217 S23: -1.7294 REMARK 3 S31: 1.6432 S32: 1.1177 S33: -0.3438 REMARK 3 TLS GROUP : 19 REMARK 3 SELECTION: CHAIN 'E' AND (RESID 2 THROUGH 124 ) REMARK 3 ORIGIN FOR THE GROUP (A): -24.1763 -26.4044 -24.1684 REMARK 3 T TENSOR REMARK 3 T11: 0.7384 T22: 0.5576 REMARK 3 T33: 0.7517 T12: 0.0038 REMARK 3 T13: 0.0470 T23: 0.0841 REMARK 3 L TENSOR REMARK 3 L11: 1.4481 L22: 1.9126 REMARK 3 L33: 5.2932 L12: -1.2649 REMARK 3 L13: -1.4964 L23: -0.5076 REMARK 3 S TENSOR REMARK 3 S11: -0.2485 S12: -0.0872 S13: -0.1462 REMARK 3 S21: 0.0453 S22: 0.2796 S23: -0.0459 REMARK 3 S31: 0.3452 S32: -0.2470 S33: -0.0002 REMARK 3 TLS GROUP : 20 REMARK 3 SELECTION: CHAIN 'E' AND (RESID 125 THROUGH 227 ) REMARK 3 ORIGIN FOR THE GROUP (A): -33.8181 0.9713 4.4712 REMARK 3 T TENSOR REMARK 3 T11: 0.5911 T22: 0.6999 REMARK 3 T33: 0.5910 T12: 0.0704 REMARK 3 T13: 0.0115 T23: 0.0486 REMARK 3 L TENSOR REMARK 3 L11: 3.4329 L22: 4.7942 REMARK 3 L33: 4.5009 L12: 0.3194 REMARK 3 L13: 1.0757 L23: 0.1628 REMARK 3 S TENSOR REMARK 3 S11: -0.0008 S12: -0.1159 S13: 0.0422 REMARK 3 S21: 0.2884 S22: 0.0448 S23: 0.2655 REMARK 3 S31: -0.0378 S32: -0.1374 S33: -0.0003 REMARK 3 TLS GROUP : 21 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 2 THROUGH 18 ) REMARK 3 ORIGIN FOR THE GROUP (A): 9.9499 -16.7317 -40.4007 REMARK 3 T TENSOR REMARK 3 T11: 0.8318 T22: 0.8274 REMARK 3 T33: 0.8328 T12: 0.0260 REMARK 3 T13: 0.1245 T23: 0.0498 REMARK 3 L TENSOR REMARK 3 L11: 0.4778 L22: 1.9722 REMARK 3 L33: 0.2268 L12: -1.0539 REMARK 3 L13: 0.1361 L23: 0.1249 REMARK 3 S TENSOR REMARK 3 S11: 0.0000 S12: -0.9008 S13: 0.2186 REMARK 3 S21: 0.2998 S22: -0.5496 S23: 0.0669 REMARK 3 S31: 0.5899 S32: -1.6139 S33: -0.0024 REMARK 3 TLS GROUP : 22 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 19 THROUGH 40 ) REMARK 3 ORIGIN FOR THE GROUP (A): 10.3799 -22.0777 -50.1988 REMARK 3 T TENSOR REMARK 3 T11: 1.0433 T22: 0.7824 REMARK 3 T33: 0.7465 T12: -0.2407 REMARK 3 T13: -0.0336 T23: -0.0165 REMARK 3 L TENSOR REMARK 3 L11: 0.3426 L22: 0.9685 REMARK 3 L33: 0.5343 L12: -0.5137 REMARK 3 L13: 0.3831 L23: -0.5786 REMARK 3 S TENSOR REMARK 3 S11: -0.0427 S12: -0.1016 S13: -0.4414 REMARK 3 S21: -0.0899 S22: 0.1608 S23: -0.1328 REMARK 3 S31: 0.7867 S32: -1.2119 S33: 0.0006 REMARK 3 TLS GROUP : 23 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 41 THROUGH 52 ) REMARK 3 ORIGIN FOR THE GROUP (A): 21.5501 -14.5415 -49.3577 REMARK 3 T TENSOR REMARK 3 T11: 1.0613 T22: 0.4481 REMARK 3 T33: 0.7520 T12: -0.1040 REMARK 3 T13: -0.0249 T23: -0.0347 REMARK 3 L TENSOR REMARK 3 L11: 1.4774 L22: 0.5491 REMARK 3 L33: 1.4106 L12: -0.1277 REMARK 3 L13: -0.8559 L23: -0.3726 REMARK 3 S TENSOR REMARK 3 S11: 0.5971 S12: -0.2296 S13: -0.1667 REMARK 3 S21: 0.8004 S22: -0.8664 S23: -0.7681 REMARK 3 S31: 0.8636 S32: -0.7476 S33: -0.0031 REMARK 3 TLS GROUP : 24 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 53 THROUGH 84 ) REMARK 3 ORIGIN FOR THE GROUP (A): 16.9354 -26.7847 -46.2678 REMARK 3 T TENSOR REMARK 3 T11: 1.5310 T22: 0.6761 REMARK 3 T33: 0.7894 T12: -0.2016 REMARK 3 T13: 0.0194 T23: -0.0112 REMARK 3 L TENSOR REMARK 3 L11: 1.0947 L22: 4.4778 REMARK 3 L33: 4.7223 L12: 0.9029 REMARK 3 L13: -2.1353 L23: -0.8130 REMARK 3 S TENSOR REMARK 3 S11: -0.0290 S12: -0.3310 S13: -0.1260 REMARK 3 S21: 0.9442 S22: -0.0608 S23: -0.4352 REMARK 3 S31: 2.4787 S32: 0.3888 S33: 0.0871 REMARK 3 TLS GROUP : 25 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 85 THROUGH 100 ) REMARK 3 ORIGIN FOR THE GROUP (A): 18.3515 -15.5333 -42.9176 REMARK 3 T TENSOR REMARK 3 T11: 1.2483 T22: 0.6055 REMARK 3 T33: 0.7697 T12: -0.3189 REMARK 3 T13: 0.0622 T23: 0.0711 REMARK 3 L TENSOR REMARK 3 L11: 1.6553 L22: 1.7204 REMARK 3 L33: 1.2390 L12: -1.6283 REMARK 3 L13: -0.4425 L23: 0.8095 REMARK 3 S TENSOR REMARK 3 S11: 0.2444 S12: -0.0718 S13: -0.2095 REMARK 3 S21: 1.3159 S22: 0.0476 S23: -0.1102 REMARK 3 S31: 1.6028 S32: -0.0866 S33: 0.0179 REMARK 3 TLS GROUP : 26 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 101 THROUGH 147 ) REMARK 3 ORIGIN FOR THE GROUP (A): 12.1360 -9.0640 -45.1141 REMARK 3 T TENSOR REMARK 3 T11: 0.9090 T22: 0.6608 REMARK 3 T33: 0.7507 T12: 0.0108 REMARK 3 T13: 0.0231 T23: 0.0463 REMARK 3 L TENSOR REMARK 3 L11: 0.6871 L22: 0.6697 REMARK 3 L33: 1.7503 L12: 0.5143 REMARK 3 L13: 0.0408 L23: 1.5744 REMARK 3 S TENSOR REMARK 3 S11: -0.1420 S12: -0.0259 S13: 0.0029 REMARK 3 S21: -0.2006 S22: -0.0787 S23: 0.2131 REMARK 3 S31: -0.0703 S32: -0.1450 S33: -0.0005 REMARK 3 TLS GROUP : 27 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 148 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): 5.4313 7.3968 -27.7020 REMARK 3 T TENSOR REMARK 3 T11: 0.5889 T22: 0.6907 REMARK 3 T33: 0.6161 T12: 0.0502 REMARK 3 T13: 0.0228 T23: 0.0835 REMARK 3 L TENSOR REMARK 3 L11: 1.3593 L22: 1.1937 REMARK 3 L33: 2.1466 L12: 1.0515 REMARK 3 L13: 0.9788 L23: -0.1443 REMARK 3 S TENSOR REMARK 3 S11: -0.0334 S12: 0.5675 S13: 0.1951 REMARK 3 S21: -0.6882 S22: 0.2387 S23: -0.0210 REMARK 3 S31: 0.5416 S32: -0.5869 S33: 0.0004 REMARK 3 TLS GROUP : 28 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 171 THROUGH 188 ) REMARK 3 ORIGIN FOR THE GROUP (A): 8.9643 7.7541 -32.1979 REMARK 3 T TENSOR REMARK 3 T11: 0.9120 T22: 0.9518 REMARK 3 T33: 0.6455 T12: 0.1246 REMARK 3 T13: -0.1027 T23: 0.0374 REMARK 3 L TENSOR REMARK 3 L11: 1.0508 L22: 2.0560 REMARK 3 L33: 1.3836 L12: 1.2336 REMARK 3 L13: -1.1839 L23: -1.1733 REMARK 3 S TENSOR REMARK 3 S11: -1.0113 S12: 0.2908 S13: 0.4572 REMARK 3 S21: 0.3999 S22: 0.4119 S23: -0.2701 REMARK 3 S31: -0.2928 S32: -0.8448 S33: 0.0000 REMARK 3 TLS GROUP : 29 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 189 THROUGH 216 ) REMARK 3 ORIGIN FOR THE GROUP (A): 1.9247 12.3145 -26.5963 REMARK 3 T TENSOR REMARK 3 T11: 0.5186 T22: 0.8275 REMARK 3 T33: 0.7442 T12: 0.0984 REMARK 3 T13: 0.0399 T23: 0.1553 REMARK 3 L TENSOR REMARK 3 L11: 0.7250 L22: 0.5902 REMARK 3 L33: 3.0748 L12: 0.1692 REMARK 3 L13: -0.7334 L23: -1.4164 REMARK 3 S TENSOR REMARK 3 S11: -0.2714 S12: 0.5318 S13: 0.0453 REMARK 3 S21: -0.3152 S22: 0.5461 S23: -0.0648 REMARK 3 S31: 0.7502 S32: -1.5749 S33: 0.4212 REMARK 3 TLS GROUP : 30 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 217 THROUGH 227 ) REMARK 3 ORIGIN FOR THE GROUP (A): 1.9204 10.1881 -19.9561 REMARK 3 T TENSOR REMARK 3 T11: 0.9900 T22: 1.1421 REMARK 3 T33: 0.9298 T12: -0.1214 REMARK 3 T13: 0.2358 T23: 0.2005 REMARK 3 L TENSOR REMARK 3 L11: 1.3690 L22: 0.2401 REMARK 3 L33: 1.3542 L12: -0.2754 REMARK 3 L13: 1.3911 L23: -0.1741 REMARK 3 S TENSOR REMARK 3 S11: 0.0022 S12: 0.0636 S13: 0.9968 REMARK 3 S21: 0.4723 S22: -0.0495 S23: -0.1042 REMARK 3 S31: -0.3166 S32: -0.8065 S33: -0.0006 REMARK 3 TLS GROUP : 31 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 4 THROUGH 25 ) REMARK 3 ORIGIN FOR THE GROUP (A): 20.9973 2.3216 -61.6718 REMARK 3 T TENSOR REMARK 3 T11: 1.0374 T22: 0.6699 REMARK 3 T33: 0.8739 T12: 0.0466 REMARK 3 T13: -0.0101 T23: 0.0272 REMARK 3 L TENSOR REMARK 3 L11: 2.1539 L22: 2.3454 REMARK 3 L33: 2.6995 L12: -1.1891 REMARK 3 L13: -0.8106 L23: -0.1513 REMARK 3 S TENSOR REMARK 3 S11: 0.2359 S12: 0.0036 S13: 1.5743 REMARK 3 S21: -0.4152 S22: 0.3035 S23: -1.6047 REMARK 3 S31: -1.7332 S32: 0.1629 S33: 0.1827 REMARK 3 TLS GROUP : 32 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 26 THROUGH 51 ) REMARK 3 ORIGIN FOR THE GROUP (A): 17.7143 -9.3029 -60.4646 REMARK 3 T TENSOR REMARK 3 T11: 0.8245 T22: 0.7670 REMARK 3 T33: 0.7619 T12: -0.0993 REMARK 3 T13: -0.0611 T23: 0.0189 REMARK 3 L TENSOR REMARK 3 L11: 1.4768 L22: 2.6482 REMARK 3 L33: 2.1332 L12: 1.2656 REMARK 3 L13: 0.4275 L23: -1.4695 REMARK 3 S TENSOR REMARK 3 S11: 0.1527 S12: -0.2508 S13: -0.7990 REMARK 3 S21: 0.4283 S22: -0.2416 S23: 0.0000 REMARK 3 S31: -0.2124 S32: -0.1327 S33: 0.0001 REMARK 3 TLS GROUP : 33 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 52 THROUGH 64 ) REMARK 3 ORIGIN FOR THE GROUP (A): 10.3669 -8.0714 -68.8819 REMARK 3 T TENSOR REMARK 3 T11: 0.3511 T22: 0.8561 REMARK 3 T33: 0.6477 T12: 0.1096 REMARK 3 T13: -0.0270 T23: 0.0479 REMARK 3 L TENSOR REMARK 3 L11: 0.7065 L22: 0.8903 REMARK 3 L33: 0.7074 L12: 0.0813 REMARK 3 L13: 0.0031 L23: -0.6625 REMARK 3 S TENSOR REMARK 3 S11: -0.3650 S12: 1.9792 S13: 0.2150 REMARK 3 S21: 0.1974 S22: -0.0759 S23: -0.0887 REMARK 3 S31: -0.1178 S32: -0.6474 S33: -0.0267 REMARK 3 TLS GROUP : 34 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 65 THROUGH 119 ) REMARK 3 ORIGIN FOR THE GROUP (A): 17.9418 -2.2238 -59.9805 REMARK 3 T TENSOR REMARK 3 T11: 0.9488 T22: 0.7162 REMARK 3 T33: 0.8409 T12: 0.0168 REMARK 3 T13: -0.0380 T23: -0.0230 REMARK 3 L TENSOR REMARK 3 L11: -0.1272 L22: 1.8553 REMARK 3 L33: 1.3615 L12: -1.2378 REMARK 3 L13: -0.2475 L23: 0.5363 REMARK 3 S TENSOR REMARK 3 S11: -0.2374 S12: -0.0820 S13: 0.0965 REMARK 3 S21: -0.1392 S22: 0.4364 S23: -0.0052 REMARK 3 S31: -0.7833 S32: -0.1316 S33: -0.0001 REMARK 3 TLS GROUP : 35 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 120 THROUGH 193 ) REMARK 3 ORIGIN FOR THE GROUP (A): 18.0189 14.8822 -31.4846 REMARK 3 T TENSOR REMARK 3 T11: 0.7047 T22: 0.6313 REMARK 3 T33: 0.7507 T12: 0.0880 REMARK 3 T13: 0.0384 T23: 0.0605 REMARK 3 L TENSOR REMARK 3 L11: 3.5342 L22: 2.2704 REMARK 3 L33: 4.1509 L12: -0.8409 REMARK 3 L13: -0.9495 L23: -1.0198 REMARK 3 S TENSOR REMARK 3 S11: 0.2530 S12: -0.0496 S13: 0.2955 REMARK 3 S21: -0.4243 S22: -0.0612 S23: -0.1018 REMARK 3 S31: -0.1009 S32: -0.1712 S33: -0.0001 REMARK 3 TLS GROUP : 36 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 194 THROUGH 216 ) REMARK 3 ORIGIN FOR THE GROUP (A): 21.6092 23.1010 -32.6007 REMARK 3 T TENSOR REMARK 3 T11: 0.9062 T22: 0.7194 REMARK 3 T33: 1.0086 T12: 0.1047 REMARK 3 T13: -0.0138 T23: 0.0138 REMARK 3 L TENSOR REMARK 3 L11: 2.0630 L22: 2.4182 REMARK 3 L33: 0.5012 L12: 0.6830 REMARK 3 L13: 0.2895 L23: -0.1329 REMARK 3 S TENSOR REMARK 3 S11: -0.0204 S12: 0.5350 S13: 0.5434 REMARK 3 S21: -0.5431 S22: 0.0206 S23: -0.7269 REMARK 3 S31: -0.4496 S32: 0.6113 S33: -0.0014 REMARK 3 TLS GROUP : 37 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 3 THROUGH 25 ) REMARK 3 ORIGIN FOR THE GROUP (A): -25.6732 -1.7116 -32.6804 REMARK 3 T TENSOR REMARK 3 T11: 0.5999 T22: 0.7181 REMARK 3 T33: 0.7980 T12: 0.0617 REMARK 3 T13: 0.0041 T23: 0.0325 REMARK 3 L TENSOR REMARK 3 L11: 0.6069 L22: 1.5132 REMARK 3 L33: 1.3029 L12: -0.7127 REMARK 3 L13: -0.9546 L23: 0.4982 REMARK 3 S TENSOR REMARK 3 S11: 0.2211 S12: 0.1449 S13: 1.1307 REMARK 3 S21: -0.4849 S22: -0.0858 S23: -0.6195 REMARK 3 S31: -0.9390 S32: 0.1611 S33: 0.0402 REMARK 3 TLS GROUP : 38 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 26 THROUGH 106 ) REMARK 3 ORIGIN FOR THE GROUP (A): -27.0390 -11.3199 -35.5655 REMARK 3 T TENSOR REMARK 3 T11: 0.6918 T22: 0.6706 REMARK 3 T33: 0.7189 T12: -0.0282 REMARK 3 T13: -0.0333 T23: -0.0302 REMARK 3 L TENSOR REMARK 3 L11: 0.4524 L22: 3.9484 REMARK 3 L33: 5.0288 L12: -1.2400 REMARK 3 L13: -1.1061 L23: 0.9455 REMARK 3 S TENSOR REMARK 3 S11: -0.1817 S12: 0.2307 S13: -0.0309 REMARK 3 S21: -0.1516 S22: -0.0029 S23: 0.1394 REMARK 3 S31: -0.3202 S32: -0.4312 S33: -0.0003 REMARK 3 TLS GROUP : 39 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 107 THROUGH 135 ) REMARK 3 ORIGIN FOR THE GROUP (A): -27.9182 6.3078 -7.3576 REMARK 3 T TENSOR REMARK 3 T11: 0.5693 T22: 0.8734 REMARK 3 T33: 0.7432 T12: -0.0362 REMARK 3 T13: -0.0019 T23: 0.0194 REMARK 3 L TENSOR REMARK 3 L11: 0.9444 L22: 0.6301 REMARK 3 L33: 1.4312 L12: 0.0052 REMARK 3 L13: -0.1678 L23: 0.8820 REMARK 3 S TENSOR REMARK 3 S11: 0.0436 S12: -0.1387 S13: 0.3618 REMARK 3 S21: -0.0765 S22: -0.0262 S23: -0.0554 REMARK 3 S31: -0.2897 S32: 0.5389 S33: -0.0001 REMARK 3 TLS GROUP : 40 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 136 THROUGH 215 ) REMARK 3 ORIGIN FOR THE GROUP (A): -22.7012 7.1187 -8.2863 REMARK 3 T TENSOR REMARK 3 T11: 0.6399 T22: 0.7533 REMARK 3 T33: 0.8053 T12: -0.0663 REMARK 3 T13: -0.0155 T23: 0.0517 REMARK 3 L TENSOR REMARK 3 L11: 2.1561 L22: 2.7741 REMARK 3 L33: 4.6769 L12: -1.6085 REMARK 3 L13: -2.2287 L23: -0.3773 REMARK 3 S TENSOR REMARK 3 S11: 0.0571 S12: -0.0499 S13: 0.0691 REMARK 3 S21: 0.2315 S22: 0.0754 S23: -0.4605 REMARK 3 S31: -0.5762 S32: 0.8311 S33: 0.0001 REMARK 3 TLS GROUP : 41 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 5 THROUGH 9 ) REMARK 3 ORIGIN FOR THE GROUP (A): 28.3346 23.8671 32.6097 REMARK 3 T TENSOR REMARK 3 T11: 1.3536 T22: 1.3604 REMARK 3 T33: 0.8459 T12: -0.1668 REMARK 3 T13: -0.0465 T23: 0.2014 REMARK 3 L TENSOR REMARK 3 L11: 0.1768 L22: 0.1199 REMARK 3 L33: 0.0780 L12: -0.0192 REMARK 3 L13: -0.0876 L23: 0.0824 REMARK 3 S TENSOR REMARK 3 S11: -0.6948 S12: -0.0451 S13: 1.0515 REMARK 3 S21: 0.4246 S22: -1.1649 S23: 1.1155 REMARK 3 S31: 0.5664 S32: -0.4145 S33: 0.0031 REMARK 3 TLS GROUP : 42 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 10 THROUGH 19 ) REMARK 3 ORIGIN FOR THE GROUP (A): 18.2022 29.3072 35.4079 REMARK 3 T TENSOR REMARK 3 T11: 1.2236 T22: 0.5982 REMARK 3 T33: 0.8562 T12: 0.0075 REMARK 3 T13: 0.0239 T23: -0.0610 REMARK 3 L TENSOR REMARK 3 L11: 0.4797 L22: 0.8944 REMARK 3 L33: 0.2862 L12: 0.2924 REMARK 3 L13: -0.3060 L23: 0.1215 REMARK 3 S TENSOR REMARK 3 S11: -1.0934 S12: -0.1482 S13: 0.4744 REMARK 3 S21: 0.2694 S22: 1.2287 S23: -0.5746 REMARK 3 S31: -2.4056 S32: 0.3021 S33: 0.0001 REMARK 3 TLS GROUP : 43 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 20 THROUGH 36 ) REMARK 3 ORIGIN FOR THE GROUP (A): 19.7919 33.1976 39.0403 REMARK 3 T TENSOR REMARK 3 T11: 1.4562 T22: 0.6070 REMARK 3 T33: 0.8857 T12: -0.6280 REMARK 3 T13: 0.1041 T23: 0.0133 REMARK 3 L TENSOR REMARK 3 L11: 3.1883 L22: 1.2092 REMARK 3 L33: 1.4445 L12: -0.0582 REMARK 3 L13: 0.2228 L23: 1.3271 REMARK 3 S TENSOR REMARK 3 S11: -0.4636 S12: 0.7508 S13: 1.0398 REMARK 3 S21: -1.2042 S22: 0.0610 S23: 0.3801 REMARK 3 S31: 0.1688 S32: -0.5437 S33: -0.1449 REMARK 3 TLS GROUP : 44 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 37 THROUGH 44 ) REMARK 3 ORIGIN FOR THE GROUP (A): 11.0339 39.5557 41.7774 REMARK 3 T TENSOR REMARK 3 T11: 2.2542 T22: 1.5954 REMARK 3 T33: 1.5522 T12: 0.2623 REMARK 3 T13: 0.3473 T23: -0.0920 REMARK 3 L TENSOR REMARK 3 L11: 0.0923 L22: 0.0165 REMARK 3 L33: 0.0179 L12: -0.0434 REMARK 3 L13: -0.0170 L23: 0.0019 REMARK 3 S TENSOR REMARK 3 S11: 0.0413 S12: -1.1487 S13: 1.8485 REMARK 3 S21: 0.1729 S22: -0.6193 S23: 0.4607 REMARK 3 S31: -1.0163 S32: -0.6305 S33: -0.0085 REMARK 3 TLS GROUP : 45 REMARK 3 SELECTION: CHAIN 'K' AND (RESID 2 THROUGH 18 ) REMARK 3 ORIGIN FOR THE GROUP (A): 6.7441 25.7346 11.5174 REMARK 3 T TENSOR REMARK 3 T11: 1.5238 T22: 1.2774 REMARK 3 T33: 0.9031 T12: -0.0017 REMARK 3 T13: -0.0197 T23: 0.3675 REMARK 3 L TENSOR REMARK 3 L11: 0.7731 L22: 0.4592 REMARK 3 L33: -0.0220 L12: 0.4092 REMARK 3 L13: -0.0920 L23: -0.0683 REMARK 3 S TENSOR REMARK 3 S11: 0.4280 S12: -0.1497 S13: -0.2326 REMARK 3 S21: 0.1368 S22: 0.0890 S23: -0.0307 REMARK 3 S31: -1.1206 S32: -0.1754 S33: 0.0007 REMARK 3 TLS GROUP : 46 REMARK 3 SELECTION: CHAIN 'K' AND (RESID 19 THROUGH 124 ) REMARK 3 ORIGIN FOR THE GROUP (A): 12.2163 25.8936 21.4507 REMARK 3 T TENSOR REMARK 3 T11: 1.2563 T22: 0.7663 REMARK 3 T33: 0.8217 T12: 0.1098 REMARK 3 T13: -0.0085 T23: 0.0731 REMARK 3 L TENSOR REMARK 3 L11: 1.3033 L22: 3.3426 REMARK 3 L33: 4.6749 L12: 2.4346 REMARK 3 L13: 0.3159 L23: -0.3461 REMARK 3 S TENSOR REMARK 3 S11: -0.2222 S12: 0.3404 S13: 0.1899 REMARK 3 S21: -0.2602 S22: 0.3900 S23: 0.1581 REMARK 3 S31: -1.2266 S32: -0.6349 S33: 0.0002 REMARK 3 TLS GROUP : 47 REMARK 3 SELECTION: CHAIN 'K' AND (RESID 125 THROUGH 227 ) REMARK 3 ORIGIN FOR THE GROUP (A): 2.3352 -1.4801 -8.2801 REMARK 3 T TENSOR REMARK 3 T11: 0.6336 T22: 0.8724 REMARK 3 T33: 0.6536 T12: -0.0494 REMARK 3 T13: -0.0084 T23: 0.0291 REMARK 3 L TENSOR REMARK 3 L11: 2.8136 L22: 4.3468 REMARK 3 L33: 6.4757 L12: 0.9729 REMARK 3 L13: -1.8600 L23: -0.8048 REMARK 3 S TENSOR REMARK 3 S11: 0.0948 S12: 0.0145 S13: -0.0851 REMARK 3 S21: 0.2379 S22: -0.0248 S23: 0.0973 REMARK 3 S31: 0.2096 S32: -0.0487 S33: -0.0002 REMARK 3 TLS GROUP : 48 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 4 THROUGH 25 ) REMARK 3 ORIGIN FOR THE GROUP (A): 9.5971 0.7357 29.3937 REMARK 3 T TENSOR REMARK 3 T11: 0.7915 T22: 0.7154 REMARK 3 T33: 0.9203 T12: -0.1281 REMARK 3 T13: 0.0228 T23: -0.0471 REMARK 3 L TENSOR REMARK 3 L11: 0.6046 L22: 0.3463 REMARK 3 L33: 2.5415 L12: 0.1728 REMARK 3 L13: 1.0368 L23: -0.4590 REMARK 3 S TENSOR REMARK 3 S11: 0.4254 S12: 0.2709 S13: -1.2098 REMARK 3 S21: 0.5135 S22: -0.0127 S23: -0.6842 REMARK 3 S31: 0.5959 S32: -0.3580 S33: -0.0005 REMARK 3 TLS GROUP : 49 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 26 THROUGH 78 ) REMARK 3 ORIGIN FOR THE GROUP (A): 8.2416 11.0829 33.9974 REMARK 3 T TENSOR REMARK 3 T11: 0.7659 T22: 0.7570 REMARK 3 T33: 0.6335 T12: 0.0700 REMARK 3 T13: 0.0193 T23: -0.0289 REMARK 3 L TENSOR REMARK 3 L11: 1.2559 L22: 5.3348 REMARK 3 L33: 3.1667 L12: -1.1513 REMARK 3 L13: 0.6440 L23: 0.2992 REMARK 3 S TENSOR REMARK 3 S11: -0.0565 S12: -0.2638 S13: 0.2208 REMARK 3 S21: -0.1494 S22: -0.0063 S23: 0.2504 REMARK 3 S31: -0.3398 S32: -0.4541 S33: 0.0001 REMARK 3 TLS GROUP : 50 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 79 THROUGH 95 ) REMARK 3 ORIGIN FOR THE GROUP (A): 5.0683 7.6626 28.2519 REMARK 3 T TENSOR REMARK 3 T11: 0.8809 T22: 0.9390 REMARK 3 T33: 0.8238 T12: -0.0819 REMARK 3 T13: 0.0219 T23: -0.0666 REMARK 3 L TENSOR REMARK 3 L11: 0.1212 L22: 0.9043 REMARK 3 L33: 2.0297 L12: 0.3712 REMARK 3 L13: -0.4250 L23: -0.0204 REMARK 3 S TENSOR REMARK 3 S11: 0.2851 S12: 0.3074 S13: 0.0847 REMARK 3 S21: 0.3311 S22: -0.5400 S23: 0.4351 REMARK 3 S31: -0.6661 S32: -0.6654 S33: 0.0010 REMARK 3 TLS GROUP : 51 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 96 THROUGH 124 ) REMARK 3 ORIGIN FOR THE GROUP (A): 9.4851 1.3767 19.1783 REMARK 3 T TENSOR REMARK 3 T11: 0.7885 T22: 0.9412 REMARK 3 T33: 0.7912 T12: -0.1293 REMARK 3 T13: 0.0264 T23: 0.0002 REMARK 3 L TENSOR REMARK 3 L11: -0.1010 L22: 1.5337 REMARK 3 L33: 1.8811 L12: -0.1978 REMARK 3 L13: 0.5073 L23: 0.6709 REMARK 3 S TENSOR REMARK 3 S11: -0.0740 S12: 0.2726 S13: -0.1735 REMARK 3 S21: 0.2343 S22: 0.1776 S23: -0.1581 REMARK 3 S31: 0.1187 S32: 0.1267 S33: -0.0007 REMARK 3 TLS GROUP : 52 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 125 THROUGH 203 ) REMARK 3 ORIGIN FOR THE GROUP (A): 13.7077 -6.2285 1.7008 REMARK 3 T TENSOR REMARK 3 T11: 0.7729 T22: 1.1900 REMARK 3 T33: 0.8012 T12: 0.0428 REMARK 3 T13: -0.0222 T23: 0.0774 REMARK 3 L TENSOR REMARK 3 L11: 2.5279 L22: 1.7087 REMARK 3 L33: 3.0385 L12: 1.0747 REMARK 3 L13: 0.9985 L23: -1.6755 REMARK 3 S TENSOR REMARK 3 S11: 0.1127 S12: -0.0292 S13: -0.5160 REMARK 3 S21: 0.0881 S22: -0.3578 S23: -0.3534 REMARK 3 S31: 0.3634 S32: 1.0405 S33: -0.0001 REMARK 3 TLS GROUP : 53 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 204 THROUGH 215 ) REMARK 3 ORIGIN FOR THE GROUP (A): 14.3118 -14.9822 4.9065 REMARK 3 T TENSOR REMARK 3 T11: 0.8929 T22: 1.0091 REMARK 3 T33: 0.9536 T12: 0.3155 REMARK 3 T13: -0.0275 T23: 0.1113 REMARK 3 L TENSOR REMARK 3 L11: 1.4286 L22: 1.3007 REMARK 3 L33: 0.2740 L12: 1.4650 REMARK 3 L13: 0.4125 L23: 0.5552 REMARK 3 S TENSOR REMARK 3 S11: -0.4718 S12: -0.0935 S13: -0.5174 REMARK 3 S21: -0.2182 S22: -0.3700 S23: -0.0089 REMARK 3 S31: 1.1115 S32: 0.6226 S33: -0.0041 REMARK 3 REMARK 3 NCS DETAILS REMARK 3 NUMBER OF NCS GROUPS : 4 REMARK 3 NCS GROUP : ens_1 REMARK 3 NCS OPERATOR : 1 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "B" and (resid 2 through 13 or REMARK 3 (resid 14 through 15 and (name N or name REMARK 3 CA or name C or name O or name CB or name REMARK 3 CG or name CD )) or resid 16 through 46 REMARK 3 or (resid 47 and (name N or name CA or REMARK 3 name C or name O or name CB or name CG )) REMARK 3 or resid 48 through 59 or (resid 60 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB or name CG or name CD )) or resid REMARK 3 61 through 65 or (resid 66 and (name N or REMARK 3 name CA or name C or name O or name CB or REMARK 3 name CG or name CD )) or resid 67 through REMARK 3 75 or (resid 76 through 77 and (name N or REMARK 3 name CA or name C or name O or name CB )) REMARK 3 or resid 78 through 196 or (resid 197 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB )) or resid 198 through 200 or REMARK 3 (resid 201 and (name N or name CA or name REMARK 3 C or name O or name CB )) or resid 202 REMARK 3 through 227)) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 2 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "H" and (resid 2 through 5 or REMARK 3 (resid 6 and (name N or name CA or name C REMARK 3 or name O or name CB or name CG or name REMARK 3 CD )) or resid 7 through 23 or (resid 24 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB or name CG or name CD )) or REMARK 3 resid 25 through 62 or (resid 63 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB or name CG )) or resid 64 through REMARK 3 105 or (resid 106 and (name N or name CA REMARK 3 or name C or name O or name CB or name CG REMARK 3 )) or resid 107 through 171 or (resid 172 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB or name CG )) or resid 173 REMARK 3 through 203 or (resid 204 and (name N or REMARK 3 name CA or name C or name O or name CB )) REMARK 3 or resid 205 through 224 or (resid 225 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB or name CG )) or resid 226 REMARK 3 through 227)) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 NCS GROUP : ens_2 REMARK 3 NCS OPERATOR : 1 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "C" and (resid 4 through 27 or REMARK 3 (resid 28 and (name N or name CA or name REMARK 3 C or name O or name CB )) or resid 29 REMARK 3 through 58 or (resid 59 and (name N or REMARK 3 name CA or name C or name O or name CB )) REMARK 3 or resid 60 through 82 or (resid 83 REMARK 3 through 84 and (name N or name CA or name REMARK 3 C or name O or name CB )) or resid 85 REMARK 3 through 112 or resid 114 through 117 or REMARK 3 (resid 118 and (name N or name CA or name REMARK 3 C or name O )) or resid 119 through 131 REMARK 3 or (resid 132 and (name N or name CA or REMARK 3 name C or name O or name CB or name CG or REMARK 3 name CD )) or resid 133 through 134 or REMARK 3 (resid 135 and (name N or name CA or name REMARK 3 C or name O or name CB or name CG )) or REMARK 3 resid 136 through 157 or (resid 158 REMARK 3 through 159 and (name N or name CA or REMARK 3 name C or name O or name CB )) or resid REMARK 3 160 through 171 or (resid 172 and (name N REMARK 3 or name CA or name C or name O or name CB REMARK 3 )) or resid 173 through 191 or (resid 192 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB or name CG or name CD )) or REMARK 3 resid 193 through 215 or (resid 216 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB )))) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 2 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "I" and ((resid 4 and (name N or REMARK 3 name CA or name C or name O or name CB )) REMARK 3 or resid 5 through 24 or (resid 25 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB )) or resid 26 through 56 or REMARK 3 (resid 57 and (name N or name CA or name REMARK 3 C or name O or name CB or name CG or name REMARK 3 CD or name NE )) or resid 58 through 83 REMARK 3 or (resid 84 and (name N or name CA or REMARK 3 name C or name O or name CB )) or resid REMARK 3 85 through 107 or (resid 108 and (name N REMARK 3 or name CA or name C or name O or name CB REMARK 3 )) or resid 109 through 111 or (resid 112 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB or name CG )) or (resid 114 REMARK 3 through 115 and (name N or name CA or REMARK 3 name C or name O or name CB or name CG or REMARK 3 name CD )) or (resid 116 through 117 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB )) or resid 118 through 208 or REMARK 3 (resid 209 and (name N or name CA or name REMARK 3 C or name O or name CB or name CG or name REMARK 3 CD )) or (resid 210 and (name N or name REMARK 3 CA or name C or name O or name CB or name REMARK 3 CG or name CD or name CE )) or resid 211 REMARK 3 through 216)) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 NCS GROUP : ens_3 REMARK 3 NCS OPERATOR : 1 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "E" and (resid 2 through 5 or REMARK 3 (resid 6 and (name N or name CA or name C REMARK 3 or name O or name CB or name CG )) or REMARK 3 resid 7 through 19 or (resid 20 and (name REMARK 3 N or name CA or name C or name O or name REMARK 3 CB or name CG or name CD )) or resid 21 REMARK 3 through 63 or (resid 64 and (name N or REMARK 3 name CA or name C or name O or name CB or REMARK 3 name CG or name CD )) or resid 65 through REMARK 3 72 or (resid 73 and (name N or name CA or REMARK 3 name C or name O or name CB or name CG or REMARK 3 name CD or name NE )) or (resid 74 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB or name CG )) or resid 75 through REMARK 3 82 or (resid 83 and (name N or name CA or REMARK 3 name C or name O or name CB or name CG )) REMARK 3 or resid 84 through 105 or (resid 106 and REMARK 3 (name N or name CA or name C or name O or REMARK 3 name CB or name CG )) or resid 107 REMARK 3 through 183 or (resid 184 and (name N or REMARK 3 name CA or name C or name O or name CB or REMARK 3 name CG or name CD )) or resid 185 REMARK 3 through 200 or (resid 201 and (name N or REMARK 3 name CA or name C or name O or name CB )) REMARK 3 or resid 202 through 204 or (resid 205 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB or name CG )) or resid 206 REMARK 3 through 218 or (resid 219 and (name N or REMARK 3 name CA or name C or name O or name CB or REMARK 3 name CG or name CD )) or resid 220 REMARK 3 through 226 or (resid 227 and (name N or REMARK 3 name CA or name C or name O or name CB ))) REMARK 3 ) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 2 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "K" and (resid 2 through 11 or REMARK 3 (resid 12 and (name N or name CA or name REMARK 3 C or name O or name CB )) or resid 13 or REMARK 3 (resid 14 through 15 and (name N or name REMARK 3 CA or name C or name O or name CB or name REMARK 3 CG or name CD )) or resid 16 through 59 REMARK 3 or (resid 60 and (name N or name CA or REMARK 3 name C or name O or name CB or name CG or REMARK 3 name CD )) or resid 61 through 69 or REMARK 3 (resid 70 and (name N or name CA or name REMARK 3 C or name O or name CB or name CG1 or REMARK 3 name CG2)) or resid 71 through 81 or REMARK 3 (resid 82 and (name N or name CA or name REMARK 3 C or name O or name CB or name CG or name REMARK 3 SD )) or resid 83 through 155 or (resid REMARK 3 156 and (name N or name CA or name C or REMARK 3 name O or name CB or name CG or name CD )) REMARK 3 or resid 157 through 226 or (resid 227 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB )))) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 NCS GROUP : ens_4 REMARK 3 NCS OPERATOR : 1 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "F" and (resid 4 through 115 or REMARK 3 (resid 116 through 118 and (name N or REMARK 3 name CA or name C or name O or name CB )) REMARK 3 or resid 119 through 161 or (resid 162 REMARK 3 and (name N or name CA or name C or name REMARK 3 O or name CB or name CG )) or resid 163 REMARK 3 through 208 or (resid 209 and (name N or REMARK 3 name CA or name C or name O or name CB or REMARK 3 name CG )) or resid 210 through 215)) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 2 REMARK 3 REFERENCE SELECTION: NULL REMARK 3 SELECTION : (chain "L" and (resid 4 through 170 or REMARK 3 (resid 171 and (name N or name CA or name REMARK 3 C or name O or name CB )) or resid 172 REMARK 3 through 194 or (resid 195 and (name N or REMARK 3 name CA or name C or name O or name CB )) REMARK 3 or resid 196 through 215)) REMARK 3 ATOM PAIRS NUMBER : NULL REMARK 3 RMSD : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 8QP6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 30-SEP-23. REMARK 100 THE DEPOSITION ID IS D_1292133567. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 15-MAR-19 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : 5.5 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SOLEIL REMARK 200 BEAMLINE : PROXIMA 2 REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 1.0007 REMARK 200 MONOCHROMATOR : M REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS EIGER X 9M REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : XSCALE REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 64890 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.590 REMARK 200 RESOLUTION RANGE LOW (A) : 48.630 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 99.4 REMARK 200 DATA REDUNDANCY : 13.60 REMARK 200 R MERGE (I) : NULL REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 11.1800 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.59 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.69 REMARK 200 COMPLETENESS FOR SHELL (%) : 97.6 REMARK 200 DATA REDUNDANCY IN SHELL : 13.70 REMARK 200 R MERGE FOR SHELL (I) : NULL REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : 0.740 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHENIX 1.18_3861 REMARK 200 STARTING MODEL: NULL REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 53.00 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.61 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2 M AMMONIUM ACETATE 0.1 M BIS-TRIS REMARK 280 5.5 25 % W/V PEG 3350, PH 5.5, VAPOR DIFFUSION, SITTING DROP, REMARK 280 TEMPERATURE 293K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X+1/2,-Y,Z+1/2 REMARK 290 3555 -X,Y+1/2,-Z+1/2 REMARK 290 4555 X+1/2,-Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 36.16000 REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 117.05000 REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 60.88000 REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 117.05000 REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 36.16000 REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 60.88000 REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, G, C, D, E, H, I, F, J, REMARK 350 AND CHAINS: K, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 GLY A 2 REMARK 465 SER A 3 REMARK 465 ARG A 4 REMARK 465 ASP A 22 REMARK 465 VAL A 26 REMARK 465 LYS A 27 REMARK 465 GLY A 28 REMARK 465 THR A 29 REMARK 465 GLY A 30 REMARK 465 PRO A 31 REMARK 465 GLY A 32 REMARK 465 GLY A 33 REMARK 465 VAL A 34 REMARK 465 GLU A 45 REMARK 465 GLU A 46 REMARK 465 THR A 47 REMARK 465 ALA A 48 REMARK 465 LYS A 49 REMARK 465 ALA A 50 REMARK 465 THR A 51 REMARK 465 ALA A 52 REMARK 465 GLY A 53 REMARK 465 SER A 54 REMARK 465 GLU A 55 REMARK 465 ASN A 56 REMARK 465 LEU A 57 REMARK 465 TYR A 58 REMARK 465 PHE A 59 REMARK 465 GLN A 60 REMARK 465 GLU B 1 REMARK 465 SER B 140 REMARK 465 SER B 141 REMARK 465 LYS B 142 REMARK 465 SER B 143 REMARK 465 THR B 144 REMARK 465 SER B 145 REMARK 465 GLY B 146 REMARK 465 CYS B 229 REMARK 465 GLY B 230 REMARK 465 SER B 231 REMARK 465 LEU B 232 REMARK 465 GLU B 233 REMARK 465 ASP B 234 REMARK 465 ASP B 235 REMARK 465 ASP B 236 REMARK 465 ASP B 237 REMARK 465 LYS B 238 REMARK 465 ALA B 239 REMARK 465 GLY B 240 REMARK 465 TRP B 241 REMARK 465 SER B 242 REMARK 465 HIS B 243 REMARK 465 PRO B 244 REMARK 465 GLN B 245 REMARK 465 PHE B 246 REMARK 465 GLU B 247 REMARK 465 LYS B 248 REMARK 465 GLY B 249 REMARK 465 GLY B 250 REMARK 465 GLY B 251 REMARK 465 SER B 252 REMARK 465 GLY B 253 REMARK 465 GLY B 254 REMARK 465 GLY B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 GLY B 258 REMARK 465 GLY B 259 REMARK 465 SER B 260 REMARK 465 TRP B 261 REMARK 465 SER B 262 REMARK 465 HIS B 263 REMARK 465 PRO B 264 REMARK 465 GLN B 265 REMARK 465 PHE B 266 REMARK 465 GLU B 267 REMARK 465 LYS B 268 REMARK 465 GLU B 269 REMARK 465 ILE B 270 REMARK 465 GLU B 271 REMARK 465 LEU B 272 REMARK 465 THR B 273 REMARK 465 LEU B 274 REMARK 465 THR B 275 REMARK 465 GLN B 276 REMARK 465 PRO B 277 REMARK 465 ALA B 278 REMARK 465 SER B 279 REMARK 465 ALA B 280 REMARK 465 SER B 281 REMARK 465 ALA B 282 REMARK 465 THR B 283 REMARK 465 PRO B 284 REMARK 465 GLY B 285 REMARK 465 GLN B 286 REMARK 465 ARG B 287 REMARK 465 VAL B 288 REMARK 465 THR B 289 REMARK 465 ILE B 290 REMARK 465 SER B 291 REMARK 465 CYS B 292 REMARK 465 SER B 293 REMARK 465 GLY B 294 REMARK 465 SER B 295 REMARK 465 SER B 296 REMARK 465 SER B 297 REMARK 465 ASN B 298 REMARK 465 ILE B 299 REMARK 465 GLY B 300 REMARK 465 GLY B 301 REMARK 465 ASN B 302 REMARK 465 THR B 303 REMARK 465 VAL B 304 REMARK 465 ASN B 305 REMARK 465 TRP B 306 REMARK 465 TYR B 307 REMARK 465 GLN B 308 REMARK 465 HIS B 309 REMARK 465 LEU B 310 REMARK 465 PRO B 311 REMARK 465 GLY B 312 REMARK 465 ALA B 313 REMARK 465 ALA B 314 REMARK 465 PRO B 315 REMARK 465 LYS B 316 REMARK 465 LEU B 317 REMARK 465 LEU B 318 REMARK 465 ILE B 319 REMARK 465 HIS B 320 REMARK 465 ASN B 321 REMARK 465 ASN B 322 REMARK 465 ASP B 323 REMARK 465 LEU B 324 REMARK 465 ARG B 325 REMARK 465 PRO B 326 REMARK 465 SER B 327 REMARK 465 GLY B 328 REMARK 465 VAL B 329 REMARK 465 PRO B 330 REMARK 465 ASP B 331 REMARK 465 ARG B 332 REMARK 465 PHE B 333 REMARK 465 SER B 334 REMARK 465 GLY B 335 REMARK 465 SER B 336 REMARK 465 LYS B 337 REMARK 465 SER B 338 REMARK 465 GLY B 339 REMARK 465 THR B 340 REMARK 465 SER B 341 REMARK 465 ALA B 342 REMARK 465 SER B 343 REMARK 465 LEU B 344 REMARK 465 ALA B 345 REMARK 465 VAL B 346 REMARK 465 SER B 347 REMARK 465 GLY B 348 REMARK 465 LEU B 349 REMARK 465 GLN B 350 REMARK 465 SER B 351 REMARK 465 GLU B 352 REMARK 465 ASP B 353 REMARK 465 GLU B 354 REMARK 465 ALA B 355 REMARK 465 ASP B 356 REMARK 465 TYR B 357 REMARK 465 PHE B 358 REMARK 465 CYS B 359 REMARK 465 ALA B 360 REMARK 465 ALA B 361 REMARK 465 TRP B 362 REMARK 465 ASP B 363 REMARK 465 ASP B 364 REMARK 465 GLY B 365 REMARK 465 LEU B 366 REMARK 465 ASN B 367 REMARK 465 GLY B 368 REMARK 465 TRP B 369 REMARK 465 VAL B 370 REMARK 465 PHE B 371 REMARK 465 GLY B 372 REMARK 465 GLY B 373 REMARK 465 GLY B 374 REMARK 465 THR B 375 REMARK 465 LYS B 376 REMARK 465 LEU B 377 REMARK 465 THR B 378 REMARK 465 VAL B 379 REMARK 465 LEU B 380 REMARK 465 GLY B 381 REMARK 465 GLN B 382 REMARK 465 PRO B 383 REMARK 465 LYS B 384 REMARK 465 ALA B 385 REMARK 465 ALA B 386 REMARK 465 PRO B 387 REMARK 465 SER B 388 REMARK 465 VAL B 389 REMARK 465 THR B 390 REMARK 465 LEU B 391 REMARK 465 PHE B 392 REMARK 465 PRO B 393 REMARK 465 PRO B 394 REMARK 465 SER B 395 REMARK 465 SER B 396 REMARK 465 GLU B 397 REMARK 465 GLU B 398 REMARK 465 LEU B 399 REMARK 465 GLN B 400 REMARK 465 ALA B 401 REMARK 465 ASN B 402 REMARK 465 LYS B 403 REMARK 465 ALA B 404 REMARK 465 THR B 405 REMARK 465 LEU B 406 REMARK 465 VAL B 407 REMARK 465 CYS B 408 REMARK 465 LEU B 409 REMARK 465 ILE B 410 REMARK 465 SER B 411 REMARK 465 ASP B 412 REMARK 465 PHE B 413 REMARK 465 TYR B 414 REMARK 465 PRO B 415 REMARK 465 GLY B 416 REMARK 465 ALA B 417 REMARK 465 VAL B 418 REMARK 465 THR B 419 REMARK 465 VAL B 420 REMARK 465 ALA B 421 REMARK 465 TRP B 422 REMARK 465 LYS B 423 REMARK 465 ALA B 424 REMARK 465 ASP B 425 REMARK 465 SER B 426 REMARK 465 SER B 427 REMARK 465 PRO B 428 REMARK 465 VAL B 429 REMARK 465 LYS B 430 REMARK 465 ALA B 431 REMARK 465 GLY B 432 REMARK 465 VAL B 433 REMARK 465 GLU B 434 REMARK 465 THR B 435 REMARK 465 THR B 436 REMARK 465 THR B 437 REMARK 465 PRO B 438 REMARK 465 SER B 439 REMARK 465 LYS B 440 REMARK 465 GLN B 441 REMARK 465 SER B 442 REMARK 465 ASN B 443 REMARK 465 ASN B 444 REMARK 465 LYS B 445 REMARK 465 TYR B 446 REMARK 465 ALA B 447 REMARK 465 ALA B 448 REMARK 465 SER B 449 REMARK 465 SER B 450 REMARK 465 TYR B 451 REMARK 465 LEU B 452 REMARK 465 SER B 453 REMARK 465 LEU B 454 REMARK 465 THR B 455 REMARK 465 PRO B 456 REMARK 465 GLU B 457 REMARK 465 GLN B 458 REMARK 465 TRP B 459 REMARK 465 LYS B 460 REMARK 465 SER B 461 REMARK 465 HIS B 462 REMARK 465 LYS B 463 REMARK 465 SER B 464 REMARK 465 TYR B 465 REMARK 465 SER B 466 REMARK 465 CYS B 467 REMARK 465 GLN B 468 REMARK 465 VAL B 469 REMARK 465 THR B 470 REMARK 465 HIS B 471 REMARK 465 GLU B 472 REMARK 465 GLY B 473 REMARK 465 SER B 474 REMARK 465 THR B 475 REMARK 465 VAL B 476 REMARK 465 GLU B 477 REMARK 465 LYS B 478 REMARK 465 THR B 479 REMARK 465 VAL B 480 REMARK 465 ALA B 481 REMARK 465 PRO B 482 REMARK 465 THR B 483 REMARK 465 GLU B 484 REMARK 465 CYS B 485 REMARK 465 SER B 486 REMARK 465 MET G 1 REMARK 465 GLY G 2 REMARK 465 SER G 3 REMARK 465 ARG G 4 REMARK 465 GLY G 20 REMARK 465 ILE G 21 REMARK 465 ASP G 22 REMARK 465 ALA G 23 REMARK 465 SER G 24 REMARK 465 LYS G 25 REMARK 465 VAL G 26 REMARK 465 LYS G 27 REMARK 465 GLY G 28 REMARK 465 THR G 29 REMARK 465 GLY G 30 REMARK 465 PRO G 31 REMARK 465 GLY G 32 REMARK 465 GLY G 33 REMARK 465 VAL G 34 REMARK 465 ILE G 35 REMARK 465 THR G 36 REMARK 465 VAL G 37 REMARK 465 GLU G 38 REMARK 465 ASP G 39 REMARK 465 VAL G 40 REMARK 465 LYS G 41 REMARK 465 ARG G 42 REMARK 465 TRP G 43 REMARK 465 ALA G 44 REMARK 465 GLU G 45 REMARK 465 GLU G 46 REMARK 465 THR G 47 REMARK 465 ALA G 48 REMARK 465 LYS G 49 REMARK 465 ALA G 50 REMARK 465 THR G 51 REMARK 465 ALA G 52 REMARK 465 GLY G 53 REMARK 465 SER G 54 REMARK 465 GLU G 55 REMARK 465 ASN G 56 REMARK 465 LEU G 57 REMARK 465 TYR G 58 REMARK 465 PHE G 59 REMARK 465 GLN G 60 REMARK 465 GLU C -267 REMARK 465 VAL C -266 REMARK 465 GLN C -265 REMARK 465 LEU C -264 REMARK 465 LEU C -263 REMARK 465 GLU C -262 REMARK 465 GLN C -261 REMARK 465 SER C -260 REMARK 465 GLY C -259 REMARK 465 ALA C -258 REMARK 465 GLU C -257 REMARK 465 VAL C -256 REMARK 465 LYS C -255 REMARK 465 ARG C -254 REMARK 465 PRO C -253 REMARK 465 GLY C -252 REMARK 465 ALA C -251 REMARK 465 SER C -250 REMARK 465 VAL C -249 REMARK 465 LYS C -248 REMARK 465 VAL C -247 REMARK 465 SER C -246 REMARK 465 CYS C -245 REMARK 465 LYS C -244 REMARK 465 ALA C -243 REMARK 465 SER C -242 REMARK 465 GLY C -241 REMARK 465 TYR C -240 REMARK 465 THR C -239 REMARK 465 PHE C -238 REMARK 465 THR C -237 REMARK 465 SER C -236 REMARK 465 TYR C -235 REMARK 465 ALA C -234 REMARK 465 ILE C -233 REMARK 465 HIS C -232 REMARK 465 TRP C -231 REMARK 465 VAL C -230 REMARK 465 ARG C -229 REMARK 465 GLN C -228 REMARK 465 ALA C -227 REMARK 465 PRO C -226 REMARK 465 GLY C -225 REMARK 465 GLN C -224 REMARK 465 ARG C -223 REMARK 465 LEU C -222 REMARK 465 GLU C -221 REMARK 465 TRP C -220 REMARK 465 MET C -219 REMARK 465 GLY C -218 REMARK 465 TRP C -217 REMARK 465 ILE C -216 REMARK 465 ASN C -215 REMARK 465 PRO C -214 REMARK 465 GLY C -213 REMARK 465 ASN C -212 REMARK 465 GLY C -211 REMARK 465 ASN C -210 REMARK 465 ALA C -209 REMARK 465 LYS C -208 REMARK 465 TYR C -207 REMARK 465 SER C -206 REMARK 465 GLN C -205 REMARK 465 ARG C -204 REMARK 465 PHE C -203 REMARK 465 GLN C -202 REMARK 465 GLY C -201 REMARK 465 ARG C -200 REMARK 465 VAL C -199 REMARK 465 ILE C -198 REMARK 465 ILE C -197 REMARK 465 SER C -196 REMARK 465 ARG C -195 REMARK 465 ASP C -194 REMARK 465 THR C -193 REMARK 465 SER C -192 REMARK 465 ALA C -191 REMARK 465 THR C -190 REMARK 465 THR C -189 REMARK 465 SER C -188 REMARK 465 TYR C -187 REMARK 465 MET C -186 REMARK 465 GLU C -185 REMARK 465 LEU C -184 REMARK 465 SER C -183 REMARK 465 SER C -182 REMARK 465 LEU C -181 REMARK 465 THR C -180 REMARK 465 SER C -179 REMARK 465 GLU C -178 REMARK 465 ASP C -177 REMARK 465 THR C -176 REMARK 465 ALA C -175 REMARK 465 VAL C -174 REMARK 465 TYR C -173 REMARK 465 SER C -172 REMARK 465 CYS C -171 REMARK 465 ALA C -170 REMARK 465 ARG C -169 REMARK 465 ASP C -168 REMARK 465 ARG C -167 REMARK 465 GLY C -166 REMARK 465 PHE C -165 REMARK 465 ASP C -164 REMARK 465 LEU C -163 REMARK 465 LEU C -162 REMARK 465 THR C -161 REMARK 465 GLY C -160 REMARK 465 HIS C -159 REMARK 465 TYR C -158 REMARK 465 LEU C -157 REMARK 465 GLY C -156 REMARK 465 LEU C -155 REMARK 465 ASP C -154 REMARK 465 PRO C -153 REMARK 465 TRP C -152 REMARK 465 GLY C -151 REMARK 465 GLN C -150 REMARK 465 GLY C -149 REMARK 465 THR C -148 REMARK 465 LEU C -147 REMARK 465 VAL C -146 REMARK 465 THR C -145 REMARK 465 VAL C -144 REMARK 465 SER C -143 REMARK 465 SER C -142 REMARK 465 ALA C -141 REMARK 465 SER C -140 REMARK 465 THR C -139 REMARK 465 LYS C -138 REMARK 465 GLY C -137 REMARK 465 PRO C -136 REMARK 465 SER C -135 REMARK 465 VAL C -134 REMARK 465 PHE C -133 REMARK 465 PRO C -132 REMARK 465 LEU C -131 REMARK 465 ALA C -130 REMARK 465 PRO C -129 REMARK 465 SER C -128 REMARK 465 SER C -127 REMARK 465 LYS C -126 REMARK 465 SER C -125 REMARK 465 THR C -124 REMARK 465 SER C -123 REMARK 465 GLY C -122 REMARK 465 GLY C -121 REMARK 465 THR C -120 REMARK 465 ALA C -119 REMARK 465 ALA C -118 REMARK 465 LEU C -117 REMARK 465 GLY C -116 REMARK 465 CYS C -115 REMARK 465 LEU C -114 REMARK 465 VAL C -113 REMARK 465 LYS C -112 REMARK 465 ASP C -111 REMARK 465 TYR C -110 REMARK 465 PHE C -109 REMARK 465 PRO C -108 REMARK 465 GLU C -107 REMARK 465 PRO C -106 REMARK 465 VAL C -105 REMARK 465 THR C -104 REMARK 465 VAL C -103 REMARK 465 SER C -102 REMARK 465 TRP C -101 REMARK 465 ASN C -100 REMARK 465 SER C -99 REMARK 465 GLY C -98 REMARK 465 ALA C -97 REMARK 465 LEU C -96 REMARK 465 THR C -95 REMARK 465 SER C -94 REMARK 465 GLY C -93 REMARK 465 VAL C -92 REMARK 465 HIS C -91 REMARK 465 THR C -90 REMARK 465 PHE C -89 REMARK 465 PRO C -88 REMARK 465 ALA C -87 REMARK 465 VAL C -86 REMARK 465 LEU C -85 REMARK 465 GLN C -84 REMARK 465 SER C -83 REMARK 465 SER C -82 REMARK 465 GLY C -81 REMARK 465 LEU C -80 REMARK 465 TYR C -79 REMARK 465 SER C -78 REMARK 465 LEU C -77 REMARK 465 SER C -76 REMARK 465 SER C -75 REMARK 465 VAL C -74 REMARK 465 VAL C -73 REMARK 465 THR C -72 REMARK 465 VAL C -71 REMARK 465 PRO C -70 REMARK 465 SER C -69 REMARK 465 SER C -68 REMARK 465 SER C -67 REMARK 465 LEU C -66 REMARK 465 GLY C -65 REMARK 465 THR C -64 REMARK 465 GLN C -63 REMARK 465 THR C -62 REMARK 465 TYR C -61 REMARK 465 ILE C -60 REMARK 465 CYS C -59 REMARK 465 ASN C -58 REMARK 465 VAL C -57 REMARK 465 ASN C -56 REMARK 465 HIS C -55 REMARK 465 LYS C -54 REMARK 465 PRO C -53 REMARK 465 SER C -52 REMARK 465 ASN C -51 REMARK 465 THR C -50 REMARK 465 LYS C -49 REMARK 465 VAL C -48 REMARK 465 ASP C -47 REMARK 465 LYS C -46 REMARK 465 LYS C -45 REMARK 465 VAL C -44 REMARK 465 GLU C -43 REMARK 465 PRO C -42 REMARK 465 LYS C -41 REMARK 465 SER C -40 REMARK 465 CYS C -39 REMARK 465 GLY C -38 REMARK 465 SER C -37 REMARK 465 LEU C -36 REMARK 465 GLU C -35 REMARK 465 ASP C -34 REMARK 465 ASP C -33 REMARK 465 ASP C -32 REMARK 465 ASP C -31 REMARK 465 LYS C -30 REMARK 465 ALA C -29 REMARK 465 GLY C -28 REMARK 465 TRP C -27 REMARK 465 SER C -26 REMARK 465 HIS C -25 REMARK 465 PRO C -24 REMARK 465 GLN C -23 REMARK 465 PHE C -22 REMARK 465 GLU C -21 REMARK 465 LYS C -20 REMARK 465 GLY C -19 REMARK 465 GLY C -18 REMARK 465 GLY C -17 REMARK 465 SER C -16 REMARK 465 GLY C -15 REMARK 465 GLY C -14 REMARK 465 GLY C -13 REMARK 465 SER C -12 REMARK 465 GLY C -11 REMARK 465 GLY C -10 REMARK 465 GLY C -9 REMARK 465 SER C -8 REMARK 465 TRP C -7 REMARK 465 SER C -6 REMARK 465 HIS C -5 REMARK 465 PRO C -4 REMARK 465 GLN C -3 REMARK 465 PHE C -2 REMARK 465 GLU C -1 REMARK 465 LYS C 0 REMARK 465 GLU C 1 REMARK 465 ILE C 2 REMARK 465 GLU C 3 REMARK 465 CYS C 217 REMARK 465 SER C 218 REMARK 465 MET D 1 REMARK 465 GLY D 2 REMARK 465 SER D 3 REMARK 465 ARG D 4 REMARK 465 ALA D 23 REMARK 465 SER D 24 REMARK 465 LYS D 25 REMARK 465 VAL D 26 REMARK 465 LYS D 27 REMARK 465 GLY D 28 REMARK 465 THR D 29 REMARK 465 GLY D 30 REMARK 465 PRO D 31 REMARK 465 GLY D 32 REMARK 465 GLY D 33 REMARK 465 VAL D 34 REMARK 465 ILE D 35 REMARK 465 THR D 36 REMARK 465 VAL D 37 REMARK 465 GLU D 38 REMARK 465 ASP D 39 REMARK 465 VAL D 40 REMARK 465 LYS D 41 REMARK 465 ARG D 42 REMARK 465 TRP D 43 REMARK 465 ALA D 44 REMARK 465 GLU D 45 REMARK 465 GLU D 46 REMARK 465 THR D 47 REMARK 465 ALA D 48 REMARK 465 LYS D 49 REMARK 465 ALA D 50 REMARK 465 THR D 51 REMARK 465 ALA D 52 REMARK 465 GLY D 53 REMARK 465 SER D 54 REMARK 465 GLU D 55 REMARK 465 ASN D 56 REMARK 465 LEU D 57 REMARK 465 TYR D 58 REMARK 465 PHE D 59 REMARK 465 GLN D 60 REMARK 465 GLU E 1 REMARK 465 SER E 140 REMARK 465 SER E 141 REMARK 465 LYS E 142 REMARK 465 SER E 143 REMARK 465 THR E 144 REMARK 465 SER E 145 REMARK 465 GLY E 146 REMARK 465 SER E 228 REMARK 465 CYS E 229 REMARK 465 GLY E 230 REMARK 465 SER E 231 REMARK 465 LEU E 232 REMARK 465 GLU E 233 REMARK 465 ASP E 234 REMARK 465 ASP E 235 REMARK 465 ASP E 236 REMARK 465 ASP E 237 REMARK 465 LYS E 238 REMARK 465 ALA E 239 REMARK 465 GLY E 240 REMARK 465 TRP E 241 REMARK 465 SER E 242 REMARK 465 HIS E 243 REMARK 465 PRO E 244 REMARK 465 GLN E 245 REMARK 465 PHE E 246 REMARK 465 GLU E 247 REMARK 465 LYS E 248 REMARK 465 GLY E 249 REMARK 465 GLY E 250 REMARK 465 GLY E 251 REMARK 465 SER E 252 REMARK 465 GLY E 253 REMARK 465 GLY E 254 REMARK 465 GLY E 255 REMARK 465 SER E 256 REMARK 465 GLY E 257 REMARK 465 GLY E 258 REMARK 465 GLY E 259 REMARK 465 SER E 260 REMARK 465 TRP E 261 REMARK 465 SER E 262 REMARK 465 HIS E 263 REMARK 465 PRO E 264 REMARK 465 GLN E 265 REMARK 465 PHE E 266 REMARK 465 GLU E 267 REMARK 465 LYS E 268 REMARK 465 GLU E 269 REMARK 465 ILE E 270 REMARK 465 GLU E 271 REMARK 465 LEU E 272 REMARK 465 THR E 273 REMARK 465 LEU E 274 REMARK 465 THR E 275 REMARK 465 GLN E 276 REMARK 465 PRO E 277 REMARK 465 ALA E 278 REMARK 465 SER E 279 REMARK 465 ALA E 280 REMARK 465 SER E 281 REMARK 465 ALA E 282 REMARK 465 THR E 283 REMARK 465 PRO E 284 REMARK 465 GLY E 285 REMARK 465 GLN E 286 REMARK 465 ARG E 287 REMARK 465 VAL E 288 REMARK 465 THR E 289 REMARK 465 ILE E 290 REMARK 465 SER E 291 REMARK 465 CYS E 292 REMARK 465 SER E 293 REMARK 465 GLY E 294 REMARK 465 SER E 295 REMARK 465 SER E 296 REMARK 465 SER E 297 REMARK 465 ASN E 298 REMARK 465 ILE E 299 REMARK 465 GLY E 300 REMARK 465 GLY E 301 REMARK 465 ASN E 302 REMARK 465 THR E 303 REMARK 465 VAL E 304 REMARK 465 ASN E 305 REMARK 465 TRP E 306 REMARK 465 TYR E 307 REMARK 465 GLN E 308 REMARK 465 HIS E 309 REMARK 465 LEU E 310 REMARK 465 PRO E 311 REMARK 465 GLY E 312 REMARK 465 ALA E 313 REMARK 465 ALA E 314 REMARK 465 PRO E 315 REMARK 465 LYS E 316 REMARK 465 LEU E 317 REMARK 465 LEU E 318 REMARK 465 ILE E 319 REMARK 465 HIS E 320 REMARK 465 ASN E 321 REMARK 465 ASN E 322 REMARK 465 ASP E 323 REMARK 465 LEU E 324 REMARK 465 ARG E 325 REMARK 465 PRO E 326 REMARK 465 SER E 327 REMARK 465 GLY E 328 REMARK 465 VAL E 329 REMARK 465 PRO E 330 REMARK 465 ASP E 331 REMARK 465 ARG E 332 REMARK 465 PHE E 333 REMARK 465 SER E 334 REMARK 465 GLY E 335 REMARK 465 SER E 336 REMARK 465 LYS E 337 REMARK 465 SER E 338 REMARK 465 GLY E 339 REMARK 465 THR E 340 REMARK 465 SER E 341 REMARK 465 ALA E 342 REMARK 465 SER E 343 REMARK 465 LEU E 344 REMARK 465 ALA E 345 REMARK 465 VAL E 346 REMARK 465 SER E 347 REMARK 465 GLY E 348 REMARK 465 LEU E 349 REMARK 465 GLN E 350 REMARK 465 SER E 351 REMARK 465 GLU E 352 REMARK 465 ASP E 353 REMARK 465 GLU E 354 REMARK 465 ALA E 355 REMARK 465 ASP E 356 REMARK 465 TYR E 357 REMARK 465 PHE E 358 REMARK 465 CYS E 359 REMARK 465 ALA E 360 REMARK 465 ALA E 361 REMARK 465 TRP E 362 REMARK 465 ASP E 363 REMARK 465 ASP E 364 REMARK 465 GLY E 365 REMARK 465 LEU E 366 REMARK 465 ASN E 367 REMARK 465 GLY E 368 REMARK 465 TRP E 369 REMARK 465 VAL E 370 REMARK 465 PHE E 371 REMARK 465 GLY E 372 REMARK 465 GLY E 373 REMARK 465 GLY E 374 REMARK 465 THR E 375 REMARK 465 LYS E 376 REMARK 465 LEU E 377 REMARK 465 THR E 378 REMARK 465 VAL E 379 REMARK 465 LEU E 380 REMARK 465 GLY E 381 REMARK 465 GLN E 382 REMARK 465 PRO E 383 REMARK 465 LYS E 384 REMARK 465 ALA E 385 REMARK 465 ALA E 386 REMARK 465 PRO E 387 REMARK 465 SER E 388 REMARK 465 VAL E 389 REMARK 465 THR E 390 REMARK 465 LEU E 391 REMARK 465 PHE E 392 REMARK 465 PRO E 393 REMARK 465 PRO E 394 REMARK 465 SER E 395 REMARK 465 SER E 396 REMARK 465 GLU E 397 REMARK 465 GLU E 398 REMARK 465 LEU E 399 REMARK 465 GLN E 400 REMARK 465 ALA E 401 REMARK 465 ASN E 402 REMARK 465 LYS E 403 REMARK 465 ALA E 404 REMARK 465 THR E 405 REMARK 465 LEU E 406 REMARK 465 VAL E 407 REMARK 465 CYS E 408 REMARK 465 LEU E 409 REMARK 465 ILE E 410 REMARK 465 SER E 411 REMARK 465 ASP E 412 REMARK 465 PHE E 413 REMARK 465 TYR E 414 REMARK 465 PRO E 415 REMARK 465 GLY E 416 REMARK 465 ALA E 417 REMARK 465 VAL E 418 REMARK 465 THR E 419 REMARK 465 VAL E 420 REMARK 465 ALA E 421 REMARK 465 TRP E 422 REMARK 465 LYS E 423 REMARK 465 ALA E 424 REMARK 465 ASP E 425 REMARK 465 SER E 426 REMARK 465 SER E 427 REMARK 465 PRO E 428 REMARK 465 VAL E 429 REMARK 465 LYS E 430 REMARK 465 ALA E 431 REMARK 465 GLY E 432 REMARK 465 VAL E 433 REMARK 465 GLU E 434 REMARK 465 THR E 435 REMARK 465 THR E 436 REMARK 465 THR E 437 REMARK 465 PRO E 438 REMARK 465 SER E 439 REMARK 465 LYS E 440 REMARK 465 GLN E 441 REMARK 465 SER E 442 REMARK 465 ASN E 443 REMARK 465 ASN E 444 REMARK 465 LYS E 445 REMARK 465 TYR E 446 REMARK 465 ALA E 447 REMARK 465 ALA E 448 REMARK 465 SER E 449 REMARK 465 SER E 450 REMARK 465 TYR E 451 REMARK 465 LEU E 452 REMARK 465 SER E 453 REMARK 465 LEU E 454 REMARK 465 THR E 455 REMARK 465 PRO E 456 REMARK 465 GLU E 457 REMARK 465 GLN E 458 REMARK 465 TRP E 459 REMARK 465 LYS E 460 REMARK 465 SER E 461 REMARK 465 HIS E 462 REMARK 465 LYS E 463 REMARK 465 SER E 464 REMARK 465 TYR E 465 REMARK 465 SER E 466 REMARK 465 CYS E 467 REMARK 465 GLN E 468 REMARK 465 VAL E 469 REMARK 465 THR E 470 REMARK 465 HIS E 471 REMARK 465 GLU E 472 REMARK 465 GLY E 473 REMARK 465 SER E 474 REMARK 465 THR E 475 REMARK 465 VAL E 476 REMARK 465 GLU E 477 REMARK 465 LYS E 478 REMARK 465 THR E 479 REMARK 465 VAL E 480 REMARK 465 ALA E 481 REMARK 465 PRO E 482 REMARK 465 THR E 483 REMARK 465 GLU E 484 REMARK 465 CYS E 485 REMARK 465 SER E 486 REMARK 465 GLU H 1 REMARK 465 SER H 140 REMARK 465 SER H 141 REMARK 465 LYS H 142 REMARK 465 SER H 143 REMARK 465 THR H 144 REMARK 465 SER H 145 REMARK 465 GLY H 146 REMARK 465 SER H 228 REMARK 465 CYS H 229 REMARK 465 GLY H 230 REMARK 465 SER H 231 REMARK 465 LEU H 232 REMARK 465 GLU H 233 REMARK 465 ASP H 234 REMARK 465 ASP H 235 REMARK 465 ASP H 236 REMARK 465 ASP H 237 REMARK 465 LYS H 238 REMARK 465 ALA H 239 REMARK 465 GLY H 240 REMARK 465 TRP H 241 REMARK 465 SER H 242 REMARK 465 HIS H 243 REMARK 465 PRO H 244 REMARK 465 GLN H 245 REMARK 465 PHE H 246 REMARK 465 GLU H 247 REMARK 465 LYS H 248 REMARK 465 GLY H 249 REMARK 465 GLY H 250 REMARK 465 GLY H 251 REMARK 465 SER H 252 REMARK 465 GLY H 253 REMARK 465 GLY H 254 REMARK 465 GLY H 255 REMARK 465 SER H 256 REMARK 465 GLY H 257 REMARK 465 GLY H 258 REMARK 465 GLY H 259 REMARK 465 SER H 260 REMARK 465 TRP H 261 REMARK 465 SER H 262 REMARK 465 HIS H 263 REMARK 465 PRO H 264 REMARK 465 GLN H 265 REMARK 465 PHE H 266 REMARK 465 GLU H 267 REMARK 465 LYS H 268 REMARK 465 GLU H 269 REMARK 465 ILE H 270 REMARK 465 GLU H 271 REMARK 465 LEU H 272 REMARK 465 THR H 273 REMARK 465 LEU H 274 REMARK 465 THR H 275 REMARK 465 GLN H 276 REMARK 465 PRO H 277 REMARK 465 ALA H 278 REMARK 465 SER H 279 REMARK 465 ALA H 280 REMARK 465 SER H 281 REMARK 465 ALA H 282 REMARK 465 THR H 283 REMARK 465 PRO H 284 REMARK 465 GLY H 285 REMARK 465 GLN H 286 REMARK 465 ARG H 287 REMARK 465 VAL H 288 REMARK 465 THR H 289 REMARK 465 ILE H 290 REMARK 465 SER H 291 REMARK 465 CYS H 292 REMARK 465 SER H 293 REMARK 465 GLY H 294 REMARK 465 SER H 295 REMARK 465 SER H 296 REMARK 465 SER H 297 REMARK 465 ASN H 298 REMARK 465 ILE H 299 REMARK 465 GLY H 300 REMARK 465 GLY H 301 REMARK 465 ASN H 302 REMARK 465 THR H 303 REMARK 465 VAL H 304 REMARK 465 ASN H 305 REMARK 465 TRP H 306 REMARK 465 TYR H 307 REMARK 465 GLN H 308 REMARK 465 HIS H 309 REMARK 465 LEU H 310 REMARK 465 PRO H 311 REMARK 465 GLY H 312 REMARK 465 ALA H 313 REMARK 465 ALA H 314 REMARK 465 PRO H 315 REMARK 465 LYS H 316 REMARK 465 LEU H 317 REMARK 465 LEU H 318 REMARK 465 ILE H 319 REMARK 465 HIS H 320 REMARK 465 ASN H 321 REMARK 465 ASN H 322 REMARK 465 ASP H 323 REMARK 465 LEU H 324 REMARK 465 ARG H 325 REMARK 465 PRO H 326 REMARK 465 SER H 327 REMARK 465 GLY H 328 REMARK 465 VAL H 329 REMARK 465 PRO H 330 REMARK 465 ASP H 331 REMARK 465 ARG H 332 REMARK 465 PHE H 333 REMARK 465 SER H 334 REMARK 465 GLY H 335 REMARK 465 SER H 336 REMARK 465 LYS H 337 REMARK 465 SER H 338 REMARK 465 GLY H 339 REMARK 465 THR H 340 REMARK 465 SER H 341 REMARK 465 ALA H 342 REMARK 465 SER H 343 REMARK 465 LEU H 344 REMARK 465 ALA H 345 REMARK 465 VAL H 346 REMARK 465 SER H 347 REMARK 465 GLY H 348 REMARK 465 LEU H 349 REMARK 465 GLN H 350 REMARK 465 SER H 351 REMARK 465 GLU H 352 REMARK 465 ASP H 353 REMARK 465 GLU H 354 REMARK 465 ALA H 355 REMARK 465 ASP H 356 REMARK 465 TYR H 357 REMARK 465 PHE H 358 REMARK 465 CYS H 359 REMARK 465 ALA H 360 REMARK 465 ALA H 361 REMARK 465 TRP H 362 REMARK 465 ASP H 363 REMARK 465 ASP H 364 REMARK 465 GLY H 365 REMARK 465 LEU H 366 REMARK 465 ASN H 367 REMARK 465 GLY H 368 REMARK 465 TRP H 369 REMARK 465 VAL H 370 REMARK 465 PHE H 371 REMARK 465 GLY H 372 REMARK 465 GLY H 373 REMARK 465 GLY H 374 REMARK 465 THR H 375 REMARK 465 LYS H 376 REMARK 465 LEU H 377 REMARK 465 THR H 378 REMARK 465 VAL H 379 REMARK 465 LEU H 380 REMARK 465 GLY H 381 REMARK 465 GLN H 382 REMARK 465 PRO H 383 REMARK 465 LYS H 384 REMARK 465 ALA H 385 REMARK 465 ALA H 386 REMARK 465 PRO H 387 REMARK 465 SER H 388 REMARK 465 VAL H 389 REMARK 465 THR H 390 REMARK 465 LEU H 391 REMARK 465 PHE H 392 REMARK 465 PRO H 393 REMARK 465 PRO H 394 REMARK 465 SER H 395 REMARK 465 SER H 396 REMARK 465 GLU H 397 REMARK 465 GLU H 398 REMARK 465 LEU H 399 REMARK 465 GLN H 400 REMARK 465 ALA H 401 REMARK 465 ASN H 402 REMARK 465 LYS H 403 REMARK 465 ALA H 404 REMARK 465 THR H 405 REMARK 465 LEU H 406 REMARK 465 VAL H 407 REMARK 465 CYS H 408 REMARK 465 LEU H 409 REMARK 465 ILE H 410 REMARK 465 SER H 411 REMARK 465 ASP H 412 REMARK 465 PHE H 413 REMARK 465 TYR H 414 REMARK 465 PRO H 415 REMARK 465 GLY H 416 REMARK 465 ALA H 417 REMARK 465 VAL H 418 REMARK 465 THR H 419 REMARK 465 VAL H 420 REMARK 465 ALA H 421 REMARK 465 TRP H 422 REMARK 465 LYS H 423 REMARK 465 ALA H 424 REMARK 465 ASP H 425 REMARK 465 SER H 426 REMARK 465 SER H 427 REMARK 465 PRO H 428 REMARK 465 VAL H 429 REMARK 465 LYS H 430 REMARK 465 ALA H 431 REMARK 465 GLY H 432 REMARK 465 VAL H 433 REMARK 465 GLU H 434 REMARK 465 THR H 435 REMARK 465 THR H 436 REMARK 465 THR H 437 REMARK 465 PRO H 438 REMARK 465 SER H 439 REMARK 465 LYS H 440 REMARK 465 GLN H 441 REMARK 465 SER H 442 REMARK 465 ASN H 443 REMARK 465 ASN H 444 REMARK 465 LYS H 445 REMARK 465 TYR H 446 REMARK 465 ALA H 447 REMARK 465 ALA H 448 REMARK 465 SER H 449 REMARK 465 SER H 450 REMARK 465 TYR H 451 REMARK 465 LEU H 452 REMARK 465 SER H 453 REMARK 465 LEU H 454 REMARK 465 THR H 455 REMARK 465 PRO H 456 REMARK 465 GLU H 457 REMARK 465 GLN H 458 REMARK 465 TRP H 459 REMARK 465 LYS H 460 REMARK 465 SER H 461 REMARK 465 HIS H 462 REMARK 465 LYS H 463 REMARK 465 SER H 464 REMARK 465 TYR H 465 REMARK 465 SER H 466 REMARK 465 CYS H 467 REMARK 465 GLN H 468 REMARK 465 VAL H 469 REMARK 465 THR H 470 REMARK 465 HIS H 471 REMARK 465 GLU H 472 REMARK 465 GLY H 473 REMARK 465 SER H 474 REMARK 465 THR H 475 REMARK 465 VAL H 476 REMARK 465 GLU H 477 REMARK 465 LYS H 478 REMARK 465 THR H 479 REMARK 465 VAL H 480 REMARK 465 ALA H 481 REMARK 465 PRO H 482 REMARK 465 THR H 483 REMARK 465 GLU H 484 REMARK 465 CYS H 485 REMARK 465 SER H 486 REMARK 465 GLU I -267 REMARK 465 VAL I -266 REMARK 465 GLN I -265 REMARK 465 LEU I -264 REMARK 465 LEU I -263 REMARK 465 GLU I -262 REMARK 465 GLN I -261 REMARK 465 SER I -260 REMARK 465 GLY I -259 REMARK 465 ALA I -258 REMARK 465 GLU I -257 REMARK 465 VAL I -256 REMARK 465 LYS I -255 REMARK 465 ARG I -254 REMARK 465 PRO I -253 REMARK 465 GLY I -252 REMARK 465 ALA I -251 REMARK 465 SER I -250 REMARK 465 VAL I -249 REMARK 465 LYS I -248 REMARK 465 VAL I -247 REMARK 465 SER I -246 REMARK 465 CYS I -245 REMARK 465 LYS I -244 REMARK 465 ALA I -243 REMARK 465 SER I -242 REMARK 465 GLY I -241 REMARK 465 TYR I -240 REMARK 465 THR I -239 REMARK 465 PHE I -238 REMARK 465 THR I -237 REMARK 465 SER I -236 REMARK 465 TYR I -235 REMARK 465 ALA I -234 REMARK 465 ILE I -233 REMARK 465 HIS I -232 REMARK 465 TRP I -231 REMARK 465 VAL I -230 REMARK 465 ARG I -229 REMARK 465 GLN I -228 REMARK 465 ALA I -227 REMARK 465 PRO I -226 REMARK 465 GLY I -225 REMARK 465 GLN I -224 REMARK 465 ARG I -223 REMARK 465 LEU I -222 REMARK 465 GLU I -221 REMARK 465 TRP I -220 REMARK 465 MET I -219 REMARK 465 GLY I -218 REMARK 465 TRP I -217 REMARK 465 ILE I -216 REMARK 465 ASN I -215 REMARK 465 PRO I -214 REMARK 465 GLY I -213 REMARK 465 ASN I -212 REMARK 465 GLY I -211 REMARK 465 ASN I -210 REMARK 465 ALA I -209 REMARK 465 LYS I -208 REMARK 465 TYR I -207 REMARK 465 SER I -206 REMARK 465 GLN I -205 REMARK 465 ARG I -204 REMARK 465 PHE I -203 REMARK 465 GLN I -202 REMARK 465 GLY I -201 REMARK 465 ARG I -200 REMARK 465 VAL I -199 REMARK 465 ILE I -198 REMARK 465 ILE I -197 REMARK 465 SER I -196 REMARK 465 ARG I -195 REMARK 465 ASP I -194 REMARK 465 THR I -193 REMARK 465 SER I -192 REMARK 465 ALA I -191 REMARK 465 THR I -190 REMARK 465 THR I -189 REMARK 465 SER I -188 REMARK 465 TYR I -187 REMARK 465 MET I -186 REMARK 465 GLU I -185 REMARK 465 LEU I -184 REMARK 465 SER I -183 REMARK 465 SER I -182 REMARK 465 LEU I -181 REMARK 465 THR I -180 REMARK 465 SER I -179 REMARK 465 GLU I -178 REMARK 465 ASP I -177 REMARK 465 THR I -176 REMARK 465 ALA I -175 REMARK 465 VAL I -174 REMARK 465 TYR I -173 REMARK 465 SER I -172 REMARK 465 CYS I -171 REMARK 465 ALA I -170 REMARK 465 ARG I -169 REMARK 465 ASP I -168 REMARK 465 ARG I -167 REMARK 465 GLY I -166 REMARK 465 PHE I -165 REMARK 465 ASP I -164 REMARK 465 LEU I -163 REMARK 465 LEU I -162 REMARK 465 THR I -161 REMARK 465 GLY I -160 REMARK 465 HIS I -159 REMARK 465 TYR I -158 REMARK 465 LEU I -157 REMARK 465 GLY I -156 REMARK 465 LEU I -155 REMARK 465 ASP I -154 REMARK 465 PRO I -153 REMARK 465 TRP I -152 REMARK 465 GLY I -151 REMARK 465 GLN I -150 REMARK 465 GLY I -149 REMARK 465 THR I -148 REMARK 465 LEU I -147 REMARK 465 VAL I -146 REMARK 465 THR I -145 REMARK 465 VAL I -144 REMARK 465 SER I -143 REMARK 465 SER I -142 REMARK 465 ALA I -141 REMARK 465 SER I -140 REMARK 465 THR I -139 REMARK 465 LYS I -138 REMARK 465 GLY I -137 REMARK 465 PRO I -136 REMARK 465 SER I -135 REMARK 465 VAL I -134 REMARK 465 PHE I -133 REMARK 465 PRO I -132 REMARK 465 LEU I -131 REMARK 465 ALA I -130 REMARK 465 PRO I -129 REMARK 465 SER I -128 REMARK 465 SER I -127 REMARK 465 LYS I -126 REMARK 465 SER I -125 REMARK 465 THR I -124 REMARK 465 SER I -123 REMARK 465 GLY I -122 REMARK 465 GLY I -121 REMARK 465 THR I -120 REMARK 465 ALA I -119 REMARK 465 ALA I -118 REMARK 465 LEU I -117 REMARK 465 GLY I -116 REMARK 465 CYS I -115 REMARK 465 LEU I -114 REMARK 465 VAL I -113 REMARK 465 LYS I -112 REMARK 465 ASP I -111 REMARK 465 TYR I -110 REMARK 465 PHE I -109 REMARK 465 PRO I -108 REMARK 465 GLU I -107 REMARK 465 PRO I -106 REMARK 465 VAL I -105 REMARK 465 THR I -104 REMARK 465 VAL I -103 REMARK 465 SER I -102 REMARK 465 TRP I -101 REMARK 465 ASN I -100 REMARK 465 SER I -99 REMARK 465 GLY I -98 REMARK 465 ALA I -97 REMARK 465 LEU I -96 REMARK 465 THR I -95 REMARK 465 SER I -94 REMARK 465 GLY I -93 REMARK 465 VAL I -92 REMARK 465 HIS I -91 REMARK 465 THR I -90 REMARK 465 PHE I -89 REMARK 465 PRO I -88 REMARK 465 ALA I -87 REMARK 465 VAL I -86 REMARK 465 LEU I -85 REMARK 465 GLN I -84 REMARK 465 SER I -83 REMARK 465 SER I -82 REMARK 465 GLY I -81 REMARK 465 LEU I -80 REMARK 465 TYR I -79 REMARK 465 SER I -78 REMARK 465 LEU I -77 REMARK 465 SER I -76 REMARK 465 SER I -75 REMARK 465 VAL I -74 REMARK 465 VAL I -73 REMARK 465 THR I -72 REMARK 465 VAL I -71 REMARK 465 PRO I -70 REMARK 465 SER I -69 REMARK 465 SER I -68 REMARK 465 SER I -67 REMARK 465 LEU I -66 REMARK 465 GLY I -65 REMARK 465 THR I -64 REMARK 465 GLN I -63 REMARK 465 THR I -62 REMARK 465 TYR I -61 REMARK 465 ILE I -60 REMARK 465 CYS I -59 REMARK 465 ASN I -58 REMARK 465 VAL I -57 REMARK 465 ASN I -56 REMARK 465 HIS I -55 REMARK 465 LYS I -54 REMARK 465 PRO I -53 REMARK 465 SER I -52 REMARK 465 ASN I -51 REMARK 465 THR I -50 REMARK 465 LYS I -49 REMARK 465 VAL I -48 REMARK 465 ASP I -47 REMARK 465 LYS I -46 REMARK 465 LYS I -45 REMARK 465 VAL I -44 REMARK 465 GLU I -43 REMARK 465 PRO I -42 REMARK 465 LYS I -41 REMARK 465 SER I -40 REMARK 465 CYS I -39 REMARK 465 GLY I -38 REMARK 465 SER I -37 REMARK 465 LEU I -36 REMARK 465 GLU I -35 REMARK 465 ASP I -34 REMARK 465 ASP I -33 REMARK 465 ASP I -32 REMARK 465 ASP I -31 REMARK 465 LYS I -30 REMARK 465 ALA I -29 REMARK 465 GLY I -28 REMARK 465 TRP I -27 REMARK 465 SER I -26 REMARK 465 HIS I -25 REMARK 465 PRO I -24 REMARK 465 GLN I -23 REMARK 465 PHE I -22 REMARK 465 GLU I -21 REMARK 465 LYS I -20 REMARK 465 GLY I -19 REMARK 465 GLY I -18 REMARK 465 GLY I -17 REMARK 465 SER I -16 REMARK 465 GLY I -15 REMARK 465 GLY I -14 REMARK 465 GLY I -13 REMARK 465 SER I -12 REMARK 465 GLY I -11 REMARK 465 GLY I -10 REMARK 465 GLY I -9 REMARK 465 SER I -8 REMARK 465 TRP I -7 REMARK 465 SER I -6 REMARK 465 HIS I -5 REMARK 465 PRO I -4 REMARK 465 GLN I -3 REMARK 465 PHE I -2 REMARK 465 GLU I -1 REMARK 465 LYS I 0 REMARK 465 GLU I 1 REMARK 465 ILE I 2 REMARK 465 GLU I 3 REMARK 465 GLY I 113 REMARK 465 CYS I 217 REMARK 465 SER I 218 REMARK 465 GLU F -267 REMARK 465 VAL F -266 REMARK 465 GLN F -265 REMARK 465 LEU F -264 REMARK 465 LEU F -263 REMARK 465 GLU F -262 REMARK 465 GLN F -261 REMARK 465 SER F -260 REMARK 465 GLY F -259 REMARK 465 ALA F -258 REMARK 465 GLU F -257 REMARK 465 VAL F -256 REMARK 465 LYS F -255 REMARK 465 ARG F -254 REMARK 465 PRO F -253 REMARK 465 GLY F -252 REMARK 465 ALA F -251 REMARK 465 SER F -250 REMARK 465 VAL F -249 REMARK 465 LYS F -248 REMARK 465 VAL F -247 REMARK 465 SER F -246 REMARK 465 CYS F -245 REMARK 465 LYS F -244 REMARK 465 ALA F -243 REMARK 465 SER F -242 REMARK 465 GLY F -241 REMARK 465 TYR F -240 REMARK 465 THR F -239 REMARK 465 PHE F -238 REMARK 465 THR F -237 REMARK 465 SER F -236 REMARK 465 TYR F -235 REMARK 465 ALA F -234 REMARK 465 ILE F -233 REMARK 465 HIS F -232 REMARK 465 TRP F -231 REMARK 465 VAL F -230 REMARK 465 ARG F -229 REMARK 465 GLN F -228 REMARK 465 ALA F -227 REMARK 465 PRO F -226 REMARK 465 GLY F -225 REMARK 465 GLN F -224 REMARK 465 ARG F -223 REMARK 465 LEU F -222 REMARK 465 GLU F -221 REMARK 465 TRP F -220 REMARK 465 MET F -219 REMARK 465 GLY F -218 REMARK 465 TRP F -217 REMARK 465 ILE F -216 REMARK 465 ASN F -215 REMARK 465 PRO F -214 REMARK 465 GLY F -213 REMARK 465 ASN F -212 REMARK 465 GLY F -211 REMARK 465 ASN F -210 REMARK 465 ALA F -209 REMARK 465 LYS F -208 REMARK 465 TYR F -207 REMARK 465 SER F -206 REMARK 465 GLN F -205 REMARK 465 ARG F -204 REMARK 465 PHE F -203 REMARK 465 GLN F -202 REMARK 465 GLY F -201 REMARK 465 ARG F -200 REMARK 465 VAL F -199 REMARK 465 ILE F -198 REMARK 465 ILE F -197 REMARK 465 SER F -196 REMARK 465 ARG F -195 REMARK 465 ASP F -194 REMARK 465 THR F -193 REMARK 465 SER F -192 REMARK 465 ALA F -191 REMARK 465 THR F -190 REMARK 465 THR F -189 REMARK 465 SER F -188 REMARK 465 TYR F -187 REMARK 465 MET F -186 REMARK 465 GLU F -185 REMARK 465 LEU F -184 REMARK 465 SER F -183 REMARK 465 SER F -182 REMARK 465 LEU F -181 REMARK 465 THR F -180 REMARK 465 SER F -179 REMARK 465 GLU F -178 REMARK 465 ASP F -177 REMARK 465 THR F -176 REMARK 465 ALA F -175 REMARK 465 VAL F -174 REMARK 465 TYR F -173 REMARK 465 SER F -172 REMARK 465 CYS F -171 REMARK 465 ALA F -170 REMARK 465 ARG F -169 REMARK 465 ASP F -168 REMARK 465 ARG F -167 REMARK 465 GLY F -166 REMARK 465 PHE F -165 REMARK 465 ASP F -164 REMARK 465 LEU F -163 REMARK 465 LEU F -162 REMARK 465 THR F -161 REMARK 465 GLY F -160 REMARK 465 HIS F -159 REMARK 465 TYR F -158 REMARK 465 LEU F -157 REMARK 465 GLY F -156 REMARK 465 LEU F -155 REMARK 465 ASP F -154 REMARK 465 PRO F -153 REMARK 465 TRP F -152 REMARK 465 GLY F -151 REMARK 465 GLN F -150 REMARK 465 GLY F -149 REMARK 465 THR F -148 REMARK 465 LEU F -147 REMARK 465 VAL F -146 REMARK 465 THR F -145 REMARK 465 VAL F -144 REMARK 465 SER F -143 REMARK 465 SER F -142 REMARK 465 ALA F -141 REMARK 465 SER F -140 REMARK 465 THR F -139 REMARK 465 LYS F -138 REMARK 465 GLY F -137 REMARK 465 PRO F -136 REMARK 465 SER F -135 REMARK 465 VAL F -134 REMARK 465 PHE F -133 REMARK 465 PRO F -132 REMARK 465 LEU F -131 REMARK 465 ALA F -130 REMARK 465 PRO F -129 REMARK 465 SER F -128 REMARK 465 SER F -127 REMARK 465 LYS F -126 REMARK 465 SER F -125 REMARK 465 THR F -124 REMARK 465 SER F -123 REMARK 465 GLY F -122 REMARK 465 GLY F -121 REMARK 465 THR F -120 REMARK 465 ALA F -119 REMARK 465 ALA F -118 REMARK 465 LEU F -117 REMARK 465 GLY F -116 REMARK 465 CYS F -115 REMARK 465 LEU F -114 REMARK 465 VAL F -113 REMARK 465 LYS F -112 REMARK 465 ASP F -111 REMARK 465 TYR F -110 REMARK 465 PHE F -109 REMARK 465 PRO F -108 REMARK 465 GLU F -107 REMARK 465 PRO F -106 REMARK 465 VAL F -105 REMARK 465 THR F -104 REMARK 465 VAL F -103 REMARK 465 SER F -102 REMARK 465 TRP F -101 REMARK 465 ASN F -100 REMARK 465 SER F -99 REMARK 465 GLY F -98 REMARK 465 ALA F -97 REMARK 465 LEU F -96 REMARK 465 THR F -95 REMARK 465 SER F -94 REMARK 465 GLY F -93 REMARK 465 VAL F -92 REMARK 465 HIS F -91 REMARK 465 THR F -90 REMARK 465 PHE F -89 REMARK 465 PRO F -88 REMARK 465 ALA F -87 REMARK 465 VAL F -86 REMARK 465 LEU F -85 REMARK 465 GLN F -84 REMARK 465 SER F -83 REMARK 465 SER F -82 REMARK 465 GLY F -81 REMARK 465 LEU F -80 REMARK 465 TYR F -79 REMARK 465 SER F -78 REMARK 465 LEU F -77 REMARK 465 SER F -76 REMARK 465 SER F -75 REMARK 465 VAL F -74 REMARK 465 VAL F -73 REMARK 465 THR F -72 REMARK 465 VAL F -71 REMARK 465 PRO F -70 REMARK 465 SER F -69 REMARK 465 SER F -68 REMARK 465 SER F -67 REMARK 465 LEU F -66 REMARK 465 GLY F -65 REMARK 465 THR F -64 REMARK 465 GLN F -63 REMARK 465 THR F -62 REMARK 465 TYR F -61 REMARK 465 ILE F -60 REMARK 465 CYS F -59 REMARK 465 ASN F -58 REMARK 465 VAL F -57 REMARK 465 ASN F -56 REMARK 465 HIS F -55 REMARK 465 LYS F -54 REMARK 465 PRO F -53 REMARK 465 SER F -52 REMARK 465 ASN F -51 REMARK 465 THR F -50 REMARK 465 LYS F -49 REMARK 465 VAL F -48 REMARK 465 ASP F -47 REMARK 465 LYS F -46 REMARK 465 LYS F -45 REMARK 465 VAL F -44 REMARK 465 GLU F -43 REMARK 465 PRO F -42 REMARK 465 LYS F -41 REMARK 465 SER F -40 REMARK 465 CYS F -39 REMARK 465 GLY F -38 REMARK 465 SER F -37 REMARK 465 LEU F -36 REMARK 465 GLU F -35 REMARK 465 ASP F -34 REMARK 465 ASP F -33 REMARK 465 ASP F -32 REMARK 465 ASP F -31 REMARK 465 LYS F -30 REMARK 465 ALA F -29 REMARK 465 GLY F -28 REMARK 465 TRP F -27 REMARK 465 SER F -26 REMARK 465 HIS F -25 REMARK 465 PRO F -24 REMARK 465 GLN F -23 REMARK 465 PHE F -22 REMARK 465 GLU F -21 REMARK 465 LYS F -20 REMARK 465 GLY F -19 REMARK 465 GLY F -18 REMARK 465 GLY F -17 REMARK 465 SER F -16 REMARK 465 GLY F -15 REMARK 465 GLY F -14 REMARK 465 GLY F -13 REMARK 465 SER F -12 REMARK 465 GLY F -11 REMARK 465 GLY F -10 REMARK 465 GLY F -9 REMARK 465 SER F -8 REMARK 465 TRP F -7 REMARK 465 SER F -6 REMARK 465 HIS F -5 REMARK 465 PRO F -4 REMARK 465 GLN F -3 REMARK 465 PHE F -2 REMARK 465 GLU F -1 REMARK 465 LYS F 0 REMARK 465 GLU F 1 REMARK 465 ILE F 2 REMARK 465 GLU F 216 REMARK 465 CYS F 217 REMARK 465 SER F 218 REMARK 465 MET J 1 REMARK 465 GLY J 2 REMARK 465 SER J 3 REMARK 465 ARG J 4 REMARK 465 ASP J 22 REMARK 465 ALA J 23 REMARK 465 GLY J 28 REMARK 465 THR J 29 REMARK 465 GLY J 30 REMARK 465 PRO J 31 REMARK 465 GLY J 32 REMARK 465 GLY J 33 REMARK 465 GLU J 45 REMARK 465 GLU J 46 REMARK 465 THR J 47 REMARK 465 ALA J 48 REMARK 465 LYS J 49 REMARK 465 ALA J 50 REMARK 465 THR J 51 REMARK 465 ALA J 52 REMARK 465 GLY J 53 REMARK 465 SER J 54 REMARK 465 GLU J 55 REMARK 465 ASN J 56 REMARK 465 LEU J 57 REMARK 465 TYR J 58 REMARK 465 PHE J 59 REMARK 465 GLN J 60 REMARK 465 GLU K 1 REMARK 465 SER K 140 REMARK 465 SER K 141 REMARK 465 LYS K 142 REMARK 465 SER K 143 REMARK 465 THR K 144 REMARK 465 SER K 145 REMARK 465 GLY K 146 REMARK 465 SER K 228 REMARK 465 CYS K 229 REMARK 465 GLY K 230 REMARK 465 SER K 231 REMARK 465 LEU K 232 REMARK 465 GLU K 233 REMARK 465 ASP K 234 REMARK 465 ASP K 235 REMARK 465 ASP K 236 REMARK 465 ASP K 237 REMARK 465 LYS K 238 REMARK 465 ALA K 239 REMARK 465 GLY K 240 REMARK 465 TRP K 241 REMARK 465 SER K 242 REMARK 465 HIS K 243 REMARK 465 PRO K 244 REMARK 465 GLN K 245 REMARK 465 PHE K 246 REMARK 465 GLU K 247 REMARK 465 LYS K 248 REMARK 465 GLY K 249 REMARK 465 GLY K 250 REMARK 465 GLY K 251 REMARK 465 SER K 252 REMARK 465 GLY K 253 REMARK 465 GLY K 254 REMARK 465 GLY K 255 REMARK 465 SER K 256 REMARK 465 GLY K 257 REMARK 465 GLY K 258 REMARK 465 GLY K 259 REMARK 465 SER K 260 REMARK 465 TRP K 261 REMARK 465 SER K 262 REMARK 465 HIS K 263 REMARK 465 PRO K 264 REMARK 465 GLN K 265 REMARK 465 PHE K 266 REMARK 465 GLU K 267 REMARK 465 LYS K 268 REMARK 465 GLU K 269 REMARK 465 ILE K 270 REMARK 465 GLU K 271 REMARK 465 LEU K 272 REMARK 465 THR K 273 REMARK 465 LEU K 274 REMARK 465 THR K 275 REMARK 465 GLN K 276 REMARK 465 PRO K 277 REMARK 465 ALA K 278 REMARK 465 SER K 279 REMARK 465 ALA K 280 REMARK 465 SER K 281 REMARK 465 ALA K 282 REMARK 465 THR K 283 REMARK 465 PRO K 284 REMARK 465 GLY K 285 REMARK 465 GLN K 286 REMARK 465 ARG K 287 REMARK 465 VAL K 288 REMARK 465 THR K 289 REMARK 465 ILE K 290 REMARK 465 SER K 291 REMARK 465 CYS K 292 REMARK 465 SER K 293 REMARK 465 GLY K 294 REMARK 465 SER K 295 REMARK 465 SER K 296 REMARK 465 SER K 297 REMARK 465 ASN K 298 REMARK 465 ILE K 299 REMARK 465 GLY K 300 REMARK 465 GLY K 301 REMARK 465 ASN K 302 REMARK 465 THR K 303 REMARK 465 VAL K 304 REMARK 465 ASN K 305 REMARK 465 TRP K 306 REMARK 465 TYR K 307 REMARK 465 GLN K 308 REMARK 465 HIS K 309 REMARK 465 LEU K 310 REMARK 465 PRO K 311 REMARK 465 GLY K 312 REMARK 465 ALA K 313 REMARK 465 ALA K 314 REMARK 465 PRO K 315 REMARK 465 LYS K 316 REMARK 465 LEU K 317 REMARK 465 LEU K 318 REMARK 465 ILE K 319 REMARK 465 HIS K 320 REMARK 465 ASN K 321 REMARK 465 ASN K 322 REMARK 465 ASP K 323 REMARK 465 LEU K 324 REMARK 465 ARG K 325 REMARK 465 PRO K 326 REMARK 465 SER K 327 REMARK 465 GLY K 328 REMARK 465 VAL K 329 REMARK 465 PRO K 330 REMARK 465 ASP K 331 REMARK 465 ARG K 332 REMARK 465 PHE K 333 REMARK 465 SER K 334 REMARK 465 GLY K 335 REMARK 465 SER K 336 REMARK 465 LYS K 337 REMARK 465 SER K 338 REMARK 465 GLY K 339 REMARK 465 THR K 340 REMARK 465 SER K 341 REMARK 465 ALA K 342 REMARK 465 SER K 343 REMARK 465 LEU K 344 REMARK 465 ALA K 345 REMARK 465 VAL K 346 REMARK 465 SER K 347 REMARK 465 GLY K 348 REMARK 465 LEU K 349 REMARK 465 GLN K 350 REMARK 465 SER K 351 REMARK 465 GLU K 352 REMARK 465 ASP K 353 REMARK 465 GLU K 354 REMARK 465 ALA K 355 REMARK 465 ASP K 356 REMARK 465 TYR K 357 REMARK 465 PHE K 358 REMARK 465 CYS K 359 REMARK 465 ALA K 360 REMARK 465 ALA K 361 REMARK 465 TRP K 362 REMARK 465 ASP K 363 REMARK 465 ASP K 364 REMARK 465 GLY K 365 REMARK 465 LEU K 366 REMARK 465 ASN K 367 REMARK 465 GLY K 368 REMARK 465 TRP K 369 REMARK 465 VAL K 370 REMARK 465 PHE K 371 REMARK 465 GLY K 372 REMARK 465 GLY K 373 REMARK 465 GLY K 374 REMARK 465 THR K 375 REMARK 465 LYS K 376 REMARK 465 LEU K 377 REMARK 465 THR K 378 REMARK 465 VAL K 379 REMARK 465 LEU K 380 REMARK 465 GLY K 381 REMARK 465 GLN K 382 REMARK 465 PRO K 383 REMARK 465 LYS K 384 REMARK 465 ALA K 385 REMARK 465 ALA K 386 REMARK 465 PRO K 387 REMARK 465 SER K 388 REMARK 465 VAL K 389 REMARK 465 THR K 390 REMARK 465 LEU K 391 REMARK 465 PHE K 392 REMARK 465 PRO K 393 REMARK 465 PRO K 394 REMARK 465 SER K 395 REMARK 465 SER K 396 REMARK 465 GLU K 397 REMARK 465 GLU K 398 REMARK 465 LEU K 399 REMARK 465 GLN K 400 REMARK 465 ALA K 401 REMARK 465 ASN K 402 REMARK 465 LYS K 403 REMARK 465 ALA K 404 REMARK 465 THR K 405 REMARK 465 LEU K 406 REMARK 465 VAL K 407 REMARK 465 CYS K 408 REMARK 465 LEU K 409 REMARK 465 ILE K 410 REMARK 465 SER K 411 REMARK 465 ASP K 412 REMARK 465 PHE K 413 REMARK 465 TYR K 414 REMARK 465 PRO K 415 REMARK 465 GLY K 416 REMARK 465 ALA K 417 REMARK 465 VAL K 418 REMARK 465 THR K 419 REMARK 465 VAL K 420 REMARK 465 ALA K 421 REMARK 465 TRP K 422 REMARK 465 LYS K 423 REMARK 465 ALA K 424 REMARK 465 ASP K 425 REMARK 465 SER K 426 REMARK 465 SER K 427 REMARK 465 PRO K 428 REMARK 465 VAL K 429 REMARK 465 LYS K 430 REMARK 465 ALA K 431 REMARK 465 GLY K 432 REMARK 465 VAL K 433 REMARK 465 GLU K 434 REMARK 465 THR K 435 REMARK 465 THR K 436 REMARK 465 THR K 437 REMARK 465 PRO K 438 REMARK 465 SER K 439 REMARK 465 LYS K 440 REMARK 465 GLN K 441 REMARK 465 SER K 442 REMARK 465 ASN K 443 REMARK 465 ASN K 444 REMARK 465 LYS K 445 REMARK 465 TYR K 446 REMARK 465 ALA K 447 REMARK 465 ALA K 448 REMARK 465 SER K 449 REMARK 465 SER K 450 REMARK 465 TYR K 451 REMARK 465 LEU K 452 REMARK 465 SER K 453 REMARK 465 LEU K 454 REMARK 465 THR K 455 REMARK 465 PRO K 456 REMARK 465 GLU K 457 REMARK 465 GLN K 458 REMARK 465 TRP K 459 REMARK 465 LYS K 460 REMARK 465 SER K 461 REMARK 465 HIS K 462 REMARK 465 LYS K 463 REMARK 465 SER K 464 REMARK 465 TYR K 465 REMARK 465 SER K 466 REMARK 465 CYS K 467 REMARK 465 GLN K 468 REMARK 465 VAL K 469 REMARK 465 THR K 470 REMARK 465 HIS K 471 REMARK 465 GLU K 472 REMARK 465 GLY K 473 REMARK 465 SER K 474 REMARK 465 THR K 475 REMARK 465 VAL K 476 REMARK 465 GLU K 477 REMARK 465 LYS K 478 REMARK 465 THR K 479 REMARK 465 VAL K 480 REMARK 465 ALA K 481 REMARK 465 PRO K 482 REMARK 465 THR K 483 REMARK 465 GLU K 484 REMARK 465 CYS K 485 REMARK 465 SER K 486 REMARK 465 GLU L -267 REMARK 465 VAL L -266 REMARK 465 GLN L -265 REMARK 465 LEU L -264 REMARK 465 LEU L -263 REMARK 465 GLU L -262 REMARK 465 GLN L -261 REMARK 465 SER L -260 REMARK 465 GLY L -259 REMARK 465 ALA L -258 REMARK 465 GLU L -257 REMARK 465 VAL L -256 REMARK 465 LYS L -255 REMARK 465 ARG L -254 REMARK 465 PRO L -253 REMARK 465 GLY L -252 REMARK 465 ALA L -251 REMARK 465 SER L -250 REMARK 465 VAL L -249 REMARK 465 LYS L -248 REMARK 465 VAL L -247 REMARK 465 SER L -246 REMARK 465 CYS L -245 REMARK 465 LYS L -244 REMARK 465 ALA L -243 REMARK 465 SER L -242 REMARK 465 GLY L -241 REMARK 465 TYR L -240 REMARK 465 THR L -239 REMARK 465 PHE L -238 REMARK 465 THR L -237 REMARK 465 SER L -236 REMARK 465 TYR L -235 REMARK 465 ALA L -234 REMARK 465 ILE L -233 REMARK 465 HIS L -232 REMARK 465 TRP L -231 REMARK 465 VAL L -230 REMARK 465 ARG L -229 REMARK 465 GLN L -228 REMARK 465 ALA L -227 REMARK 465 PRO L -226 REMARK 465 GLY L -225 REMARK 465 GLN L -224 REMARK 465 ARG L -223 REMARK 465 LEU L -222 REMARK 465 GLU L -221 REMARK 465 TRP L -220 REMARK 465 MET L -219 REMARK 465 GLY L -218 REMARK 465 TRP L -217 REMARK 465 ILE L -216 REMARK 465 ASN L -215 REMARK 465 PRO L -214 REMARK 465 GLY L -213 REMARK 465 ASN L -212 REMARK 465 GLY L -211 REMARK 465 ASN L -210 REMARK 465 ALA L -209 REMARK 465 LYS L -208 REMARK 465 TYR L -207 REMARK 465 SER L -206 REMARK 465 GLN L -205 REMARK 465 ARG L -204 REMARK 465 PHE L -203 REMARK 465 GLN L -202 REMARK 465 GLY L -201 REMARK 465 ARG L -200 REMARK 465 VAL L -199 REMARK 465 ILE L -198 REMARK 465 ILE L -197 REMARK 465 SER L -196 REMARK 465 ARG L -195 REMARK 465 ASP L -194 REMARK 465 THR L -193 REMARK 465 SER L -192 REMARK 465 ALA L -191 REMARK 465 THR L -190 REMARK 465 THR L -189 REMARK 465 SER L -188 REMARK 465 TYR L -187 REMARK 465 MET L -186 REMARK 465 GLU L -185 REMARK 465 LEU L -184 REMARK 465 SER L -183 REMARK 465 SER L -182 REMARK 465 LEU L -181 REMARK 465 THR L -180 REMARK 465 SER L -179 REMARK 465 GLU L -178 REMARK 465 ASP L -177 REMARK 465 THR L -176 REMARK 465 ALA L -175 REMARK 465 VAL L -174 REMARK 465 TYR L -173 REMARK 465 SER L -172 REMARK 465 CYS L -171 REMARK 465 ALA L -170 REMARK 465 ARG L -169 REMARK 465 ASP L -168 REMARK 465 ARG L -167 REMARK 465 GLY L -166 REMARK 465 PHE L -165 REMARK 465 ASP L -164 REMARK 465 LEU L -163 REMARK 465 LEU L -162 REMARK 465 THR L -161 REMARK 465 GLY L -160 REMARK 465 HIS L -159 REMARK 465 TYR L -158 REMARK 465 LEU L -157 REMARK 465 GLY L -156 REMARK 465 LEU L -155 REMARK 465 ASP L -154 REMARK 465 PRO L -153 REMARK 465 TRP L -152 REMARK 465 GLY L -151 REMARK 465 GLN L -150 REMARK 465 GLY L -149 REMARK 465 THR L -148 REMARK 465 LEU L -147 REMARK 465 VAL L -146 REMARK 465 THR L -145 REMARK 465 VAL L -144 REMARK 465 SER L -143 REMARK 465 SER L -142 REMARK 465 ALA L -141 REMARK 465 SER L -140 REMARK 465 THR L -139 REMARK 465 LYS L -138 REMARK 465 GLY L -137 REMARK 465 PRO L -136 REMARK 465 SER L -135 REMARK 465 VAL L -134 REMARK 465 PHE L -133 REMARK 465 PRO L -132 REMARK 465 LEU L -131 REMARK 465 ALA L -130 REMARK 465 PRO L -129 REMARK 465 SER L -128 REMARK 465 SER L -127 REMARK 465 LYS L -126 REMARK 465 SER L -125 REMARK 465 THR L -124 REMARK 465 SER L -123 REMARK 465 GLY L -122 REMARK 465 GLY L -121 REMARK 465 THR L -120 REMARK 465 ALA L -119 REMARK 465 ALA L -118 REMARK 465 LEU L -117 REMARK 465 GLY L -116 REMARK 465 CYS L -115 REMARK 465 LEU L -114 REMARK 465 VAL L -113 REMARK 465 LYS L -112 REMARK 465 ASP L -111 REMARK 465 TYR L -110 REMARK 465 PHE L -109 REMARK 465 PRO L -108 REMARK 465 GLU L -107 REMARK 465 PRO L -106 REMARK 465 VAL L -105 REMARK 465 THR L -104 REMARK 465 VAL L -103 REMARK 465 SER L -102 REMARK 465 TRP L -101 REMARK 465 ASN L -100 REMARK 465 SER L -99 REMARK 465 GLY L -98 REMARK 465 ALA L -97 REMARK 465 LEU L -96 REMARK 465 THR L -95 REMARK 465 SER L -94 REMARK 465 GLY L -93 REMARK 465 VAL L -92 REMARK 465 HIS L -91 REMARK 465 THR L -90 REMARK 465 PHE L -89 REMARK 465 PRO L -88 REMARK 465 ALA L -87 REMARK 465 VAL L -86 REMARK 465 LEU L -85 REMARK 465 GLN L -84 REMARK 465 SER L -83 REMARK 465 SER L -82 REMARK 465 GLY L -81 REMARK 465 LEU L -80 REMARK 465 TYR L -79 REMARK 465 SER L -78 REMARK 465 LEU L -77 REMARK 465 SER L -76 REMARK 465 SER L -75 REMARK 465 VAL L -74 REMARK 465 VAL L -73 REMARK 465 THR L -72 REMARK 465 VAL L -71 REMARK 465 PRO L -70 REMARK 465 SER L -69 REMARK 465 SER L -68 REMARK 465 SER L -67 REMARK 465 LEU L -66 REMARK 465 GLY L -65 REMARK 465 THR L -64 REMARK 465 GLN L -63 REMARK 465 THR L -62 REMARK 465 TYR L -61 REMARK 465 ILE L -60 REMARK 465 CYS L -59 REMARK 465 ASN L -58 REMARK 465 VAL L -57 REMARK 465 ASN L -56 REMARK 465 HIS L -55 REMARK 465 LYS L -54 REMARK 465 PRO L -53 REMARK 465 SER L -52 REMARK 465 ASN L -51 REMARK 465 THR L -50 REMARK 465 LYS L -49 REMARK 465 VAL L -48 REMARK 465 ASP L -47 REMARK 465 LYS L -46 REMARK 465 LYS L -45 REMARK 465 VAL L -44 REMARK 465 GLU L -43 REMARK 465 PRO L -42 REMARK 465 LYS L -41 REMARK 465 SER L -40 REMARK 465 CYS L -39 REMARK 465 GLY L -38 REMARK 465 SER L -37 REMARK 465 LEU L -36 REMARK 465 GLU L -35 REMARK 465 ASP L -34 REMARK 465 ASP L -33 REMARK 465 ASP L -32 REMARK 465 ASP L -31 REMARK 465 LYS L -30 REMARK 465 ALA L -29 REMARK 465 GLY L -28 REMARK 465 TRP L -27 REMARK 465 SER L -26 REMARK 465 HIS L -25 REMARK 465 PRO L -24 REMARK 465 GLN L -23 REMARK 465 PHE L -22 REMARK 465 GLU L -21 REMARK 465 LYS L -20 REMARK 465 GLY L -19 REMARK 465 GLY L -18 REMARK 465 GLY L -17 REMARK 465 SER L -16 REMARK 465 GLY L -15 REMARK 465 GLY L -14 REMARK 465 GLY L -13 REMARK 465 SER L -12 REMARK 465 GLY L -11 REMARK 465 GLY L -10 REMARK 465 GLY L -9 REMARK 465 SER L -8 REMARK 465 TRP L -7 REMARK 465 SER L -6 REMARK 465 HIS L -5 REMARK 465 PRO L -4 REMARK 465 GLN L -3 REMARK 465 PHE L -2 REMARK 465 GLU L -1 REMARK 465 LYS L 0 REMARK 465 GLU L 1 REMARK 465 ILE L 2 REMARK 465 GLU L 3 REMARK 465 GLU L 216 REMARK 465 CYS L 217 REMARK 465 SER L 218 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 SER A 24 OG REMARK 470 LYS A 25 NZ REMARK 470 ILE A 35 CG1 CG2 CD1 REMARK 470 GLU A 38 OE1 OE2 REMARK 470 ASP A 39 OD1 OD2 REMARK 470 LYS A 41 CG CD CE NZ REMARK 470 ARG A 42 CG CD NE CZ NH1 NH2 REMARK 470 TRP A 43 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP A 43 CZ3 CH2 REMARK 470 GLU B 6 OE1 OE2 REMARK 470 ARG B 14 CZ NH1 NH2 REMARK 470 LYS B 24 CE NZ REMARK 470 LYS B 60 NZ REMARK 470 GLN B 63 CD OE1 NE2 REMARK 470 ARG B 64 CZ NH1 NH2 REMARK 470 LEU B 105 CG CD1 CD2 REMARK 470 LEU B 106 CD1 CD2 REMARK 470 LEU B 172 CD1 CD2 REMARK 470 LEU B 202 CD1 CD2 REMARK 470 THR B 204 OG1 CG2 REMARK 470 GLN B 205 OE1 NE2 REMARK 470 ILE B 208 CD1 REMARK 470 LYS B 214 CD CE NZ REMARK 470 LYS B 219 CE NZ REMARK 470 GLU B 225 CD OE1 OE2 REMARK 470 LYS B 227 CG CD CE NZ REMARK 470 GLU G 5 CD OE1 OE2 REMARK 470 LEU G 15 CD1 CD2 REMARK 470 LEU C 4 CG CD1 CD2 REMARK 470 SER C 25 OG REMARK 470 LYS C 48 CE NZ REMARK 470 ILE C 51 CD1 REMARK 470 ARG C 57 CZ NH1 NH2 REMARK 470 ASP C 63 CG OD1 OD2 REMARK 470 GLU C 84 CG CD OE1 OE2 REMARK 470 GLU C 86 CG CD OE1 OE2 REMARK 470 LYS C 108 CG CD CE NZ REMARK 470 LEU C 112 CD1 CD2 REMARK 470 GLN C 114 OE1 NE2 REMARK 470 LYS C 116 CG CD CE NZ REMARK 470 LYS C 135 CE NZ REMARK 470 LYS C 155 CD CE NZ REMARK 470 SER C 159 OG REMARK 470 LYS C 162 CD CE NZ REMARK 470 LYS C 172 CD CE NZ REMARK 470 GLU C 189 CG CD OE1 OE2 REMARK 470 LYS C 192 NZ REMARK 470 LYS C 195 CG CD CE NZ REMARK 470 GLU C 209 OE1 OE2 REMARK 470 LYS C 210 NZ REMARK 470 GLU D 5 CG CD OE1 OE2 REMARK 470 VAL D 6 CG1 CG2 REMARK 470 ASP D 22 CG OD1 OD2 REMARK 470 VAL E 12 CG1 CG2 REMARK 470 ARG E 14 NE CZ NH1 NH2 REMARK 470 LYS E 24 CE NZ REMARK 470 ASN E 58 OD1 ND2 REMARK 470 LYS E 60 CE NZ REMARK 470 GLN E 63 CD OE1 NE2 REMARK 470 ARG E 64 CZ NH1 NH2 REMARK 470 GLN E 66 OE1 NE2 REMARK 470 ILE E 70 CD1 REMARK 470 MET E 82 CE REMARK 470 GLU E 90 CD OE1 OE2 REMARK 470 LYS E 156 CE NZ REMARK 470 SER E 174 OG REMARK 470 SER E 185 OG REMARK 470 GLN E 205 OE1 NE2 REMARK 470 LYS E 223 NZ REMARK 470 LYS E 227 CG CD CE NZ REMARK 470 ARG H 14 NE CZ NH1 NH2 REMARK 470 LYS H 24 NZ REMARK 470 GLU H 47 CD OE1 OE2 REMARK 470 LYS H 60 CE NZ REMARK 470 ARG H 64 CZ NH1 NH2 REMARK 470 GLN H 66 OE1 NE2 REMARK 470 SER H 76 OG REMARK 470 LEU H 105 CG CD1 CD2 REMARK 470 VAL H 197 CG1 CG2 REMARK 470 SER H 201 OG REMARK 470 LEU H 202 CD1 CD2 REMARK 470 GLN H 205 OE1 NE2 REMARK 470 ILE H 208 CD1 REMARK 470 LYS H 214 CD CE NZ REMARK 470 LYS H 219 CE NZ REMARK 470 LYS H 227 CG CD CE NZ REMARK 470 SER I 28 OG REMARK 470 LYS I 48 CE NZ REMARK 470 ILE I 51 CD1 REMARK 470 SER I 59 OG REMARK 470 ASP I 63 CG OD1 OD2 REMARK 470 SER I 83 OG REMARK 470 GLU I 84 OE1 OE2 REMARK 470 GLU I 86 CG CD OE1 OE2 REMARK 470 LYS I 108 NZ REMARK 470 LYS I 116 CD CE NZ REMARK 470 ALA I 118 CB REMARK 470 GLN I 132 OE1 NE2 REMARK 470 LYS I 135 CD CE NZ REMARK 470 LYS I 155 CD CE NZ REMARK 470 SER I 158 OG REMARK 470 SER I 159 OG REMARK 470 LYS I 162 CD CE NZ REMARK 470 LYS I 172 CG CD CE NZ REMARK 470 GLU I 189 CG CD OE1 OE2 REMARK 470 LYS I 192 CE NZ REMARK 470 LYS I 195 CG CD CE NZ REMARK 470 GLU I 216 CG CD OE1 OE2 REMARK 470 ARG F 57 CZ NH1 NH2 REMARK 470 SER F 79 OG REMARK 470 LYS F 108 NZ REMARK 470 LYS F 135 CE NZ REMARK 470 LYS F 155 CG CD CE NZ REMARK 470 SER F 158 OG REMARK 470 SER F 159 OG REMARK 470 LYS F 162 CE NZ REMARK 470 SER F 171 OG REMARK 470 LYS F 172 CE NZ REMARK 470 LYS F 192 CG CD CE NZ REMARK 470 LYS F 195 CG CD CE NZ REMARK 470 SER F 198 OG REMARK 470 GLU J 5 CG CD OE1 OE2 REMARK 470 LEU J 19 CD1 CD2 REMARK 470 LYS J 25 CG CD CE NZ REMARK 470 ILE J 35 CG1 CG2 CD1 REMARK 470 GLU J 38 OE1 OE2 REMARK 470 ASP J 39 OD1 OD2 REMARK 470 LYS J 41 CB CG CD CE NZ REMARK 470 ARG J 42 CG CD NE CZ NH1 NH2 REMARK 470 TRP J 43 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP J 43 CZ3 CH2 REMARK 470 GLU K 6 CD OE1 OE2 REMARK 470 ARG K 14 CZ NH1 NH2 REMARK 470 LYS K 20 CE NZ REMARK 470 LYS K 24 CE NZ REMARK 470 ASN K 58 OD1 ND2 REMARK 470 GLN K 63 CD OE1 NE2 REMARK 470 ARG K 64 NE CZ NH1 NH2 REMARK 470 GLN K 66 OE1 NE2 REMARK 470 ARG K 73 CZ NH1 NH2 REMARK 470 ASP K 74 OD1 OD2 REMARK 470 GLU K 83 CD OE1 OE2 REMARK 470 GLU K 90 CD OE1 OE2 REMARK 470 LEU K 106 CD1 CD2 REMARK 470 LYS K 156 NZ REMARK 470 SER K 174 OG REMARK 470 GLN K 184 OE1 NE2 REMARK 470 SER K 185 OG REMARK 470 SER K 201 OG REMARK 470 GLN K 205 CD OE1 NE2 REMARK 470 LYS K 219 CE NZ REMARK 470 LYS K 223 NZ REMARK 470 ARG L 57 CZ NH1 NH2 REMARK 470 SER L 79 OG REMARK 470 LYS L 108 NZ REMARK 470 LYS L 116 CG CD CE NZ REMARK 470 LYS L 135 CE NZ REMARK 470 LYS L 155 CG CD CE NZ REMARK 470 SER L 158 OG REMARK 470 SER L 159 OG REMARK 470 LYS L 162 CD CE NZ REMARK 470 LYS L 172 CE NZ REMARK 470 LYS L 192 CG CD CE NZ REMARK 470 LYS L 195 CD CE NZ REMARK 470 SER L 198 OG REMARK 470 GLU L 209 CD OE1 OE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASP B 157 61.67 60.24 REMARK 500 ASN C 54 -19.79 74.75 REMARK 500 ASP C 55 2.28 -151.49 REMARK 500 ALA C 87 -168.72 -162.48 REMARK 500 SER C 158 -0.31 70.23 REMARK 500 ASP H 157 61.80 61.09 REMARK 500 ASN I 54 -20.10 74.13 REMARK 500 ASP I 55 1.58 -151.85 REMARK 500 ALA I 87 -168.43 -161.86 REMARK 500 SER I 158 -0.07 69.98 REMARK 500 ASN F 54 -20.52 74.99 REMARK 500 ASP F 55 -15.69 -147.30 REMARK 500 ASN L 54 -20.10 74.62 REMARK 500 ASP L 55 -16.18 -147.07 REMARK 500 REMARK 500 REMARK: NULL DBREF 8QP6 A 1 60 PDB 8QP6 8QP6 1 60 DBREF 8QP6 B 1 486 PDB 8QP6 8QP6 1 486 DBREF 8QP6 G 1 60 PDB 8QP6 8QP6 1 60 DBREF 8QP6 C -267 218 PDB 8QP6 8QP6 -267 218 DBREF 8QP6 D 1 60 PDB 8QP6 8QP6 1 60 DBREF 8QP6 E 1 486 PDB 8QP6 8QP6 1 486 DBREF 8QP6 H 1 486 PDB 8QP6 8QP6 1 486 DBREF 8QP6 I -267 218 PDB 8QP6 8QP6 -267 218 DBREF 8QP6 F -267 218 PDB 8QP6 8QP6 -267 218 DBREF 8QP6 J 1 60 PDB 8QP6 8QP6 1 60 DBREF 8QP6 K 1 486 PDB 8QP6 8QP6 1 486 DBREF 8QP6 L -267 218 PDB 8QP6 8QP6 -267 218 SEQRES 1 A 60 MET GLY SER ARG GLU VAL ALA THR PRO HIS ARG ALA ALA SEQRES 2 A 60 TRP LEU ALA MET MET LEU GLY ILE ASP ALA SER LYS VAL SEQRES 3 A 60 LYS GLY THR GLY PRO GLY GLY VAL ILE THR VAL GLU ASP SEQRES 4 A 60 VAL LYS ARG TRP ALA GLU GLU THR ALA LYS ALA THR ALA SEQRES 5 A 60 GLY SER GLU ASN LEU TYR PHE GLN SEQRES 1 B 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 B 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 B 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 B 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 B 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 B 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 B 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 B 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 B 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 B 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 B 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 B 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 B 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 B 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 B 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 B 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 B 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 B 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 B 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 B 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 B 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 B 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 B 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 B 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 B 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 B 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 B 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 B 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 B 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 B 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 B 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 B 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 B 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 B 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 B 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 B 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 B 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 B 486 PRO THR GLU CYS SER SEQRES 1 G 60 MET GLY SER ARG GLU VAL ALA THR PRO HIS ARG ALA ALA SEQRES 2 G 60 TRP LEU ALA MET MET LEU GLY ILE ASP ALA SER LYS VAL SEQRES 3 G 60 LYS GLY THR GLY PRO GLY GLY VAL ILE THR VAL GLU ASP SEQRES 4 G 60 VAL LYS ARG TRP ALA GLU GLU THR ALA LYS ALA THR ALA SEQRES 5 G 60 GLY SER GLU ASN LEU TYR PHE GLN SEQRES 1 C 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 C 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 C 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 C 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 C 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 C 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 C 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 C 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 C 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 C 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 C 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 C 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 C 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 C 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 C 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 C 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 C 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 C 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 C 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 C 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 C 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 C 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 C 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 C 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 C 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 C 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 C 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 C 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 C 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 C 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 C 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 C 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 C 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 C 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 C 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 C 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 C 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 C 486 PRO THR GLU CYS SER SEQRES 1 D 60 MET GLY SER ARG GLU VAL ALA THR PRO HIS ARG ALA ALA SEQRES 2 D 60 TRP LEU ALA MET MET LEU GLY ILE ASP ALA SER LYS VAL SEQRES 3 D 60 LYS GLY THR GLY PRO GLY GLY VAL ILE THR VAL GLU ASP SEQRES 4 D 60 VAL LYS ARG TRP ALA GLU GLU THR ALA LYS ALA THR ALA SEQRES 5 D 60 GLY SER GLU ASN LEU TYR PHE GLN SEQRES 1 E 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 E 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 E 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 E 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 E 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 E 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 E 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 E 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 E 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 E 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 E 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 E 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 E 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 E 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 E 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 E 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 E 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 E 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 E 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 E 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 E 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 E 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 E 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 E 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 E 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 E 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 E 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 E 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 E 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 E 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 E 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 E 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 E 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 E 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 E 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 E 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 E 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 E 486 PRO THR GLU CYS SER SEQRES 1 H 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 H 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 H 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 H 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 H 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 H 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 H 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 H 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 H 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 H 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 H 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 H 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 H 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 H 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 H 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 H 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 H 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 H 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 H 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 H 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 H 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 H 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 H 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 H 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 H 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 H 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 H 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 H 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 H 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 H 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 H 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 H 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 H 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 H 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 H 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 H 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 H 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 H 486 PRO THR GLU CYS SER SEQRES 1 I 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 I 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 I 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 I 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 I 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 I 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 I 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 I 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 I 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 I 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 I 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 I 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 I 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 I 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 I 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 I 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 I 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 I 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 I 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 I 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 I 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 I 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 I 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 I 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 I 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 I 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 I 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 I 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 I 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 I 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 I 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 I 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 I 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 I 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 I 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 I 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 I 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 I 486 PRO THR GLU CYS SER SEQRES 1 F 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 F 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 F 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 F 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 F 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 F 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 F 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 F 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 F 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 F 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 F 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 F 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 F 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 F 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 F 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 F 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 F 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 F 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 F 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 F 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 F 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 F 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 F 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 F 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 F 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 F 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 F 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 F 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 F 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 F 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 F 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 F 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 F 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 F 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 F 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 F 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 F 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 F 486 PRO THR GLU CYS SER SEQRES 1 J 60 MET GLY SER ARG GLU VAL ALA THR PRO HIS ARG ALA ALA SEQRES 2 J 60 TRP LEU ALA MET MET LEU GLY ILE ASP ALA SER LYS VAL SEQRES 3 J 60 LYS GLY THR GLY PRO GLY GLY VAL ILE THR VAL GLU ASP SEQRES 4 J 60 VAL LYS ARG TRP ALA GLU GLU THR ALA LYS ALA THR ALA SEQRES 5 J 60 GLY SER GLU ASN LEU TYR PHE GLN SEQRES 1 K 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 K 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 K 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 K 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 K 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 K 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 K 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 K 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 K 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 K 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 K 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 K 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 K 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 K 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 K 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 K 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 K 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 K 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 K 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 K 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 K 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 K 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 K 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 K 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 K 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 K 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 K 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 K 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 K 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 K 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 K 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 K 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 K 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 K 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 K 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 K 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 K 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 K 486 PRO THR GLU CYS SER SEQRES 1 L 486 GLU VAL GLN LEU LEU GLU GLN SER GLY ALA GLU VAL LYS SEQRES 2 L 486 ARG PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER SEQRES 3 L 486 GLY TYR THR PHE THR SER TYR ALA ILE HIS TRP VAL ARG SEQRES 4 L 486 GLN ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE SEQRES 5 L 486 ASN PRO GLY ASN GLY ASN ALA LYS TYR SER GLN ARG PHE SEQRES 6 L 486 GLN GLY ARG VAL ILE ILE SER ARG ASP THR SER ALA THR SEQRES 7 L 486 THR SER TYR MET GLU LEU SER SER LEU THR SER GLU ASP SEQRES 8 L 486 THR ALA VAL TYR SER CYS ALA ARG ASP ARG GLY PHE ASP SEQRES 9 L 486 LEU LEU THR GLY HIS TYR LEU GLY LEU ASP PRO TRP GLY SEQRES 10 L 486 GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 L 486 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 L 486 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 L 486 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 L 486 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 L 486 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 L 486 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 L 486 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 L 486 LYS LYS VAL GLU PRO LYS SER CYS GLY SER LEU GLU ASP SEQRES 19 L 486 ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE GLU SEQRES 20 L 486 LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY SER SEQRES 21 L 486 TRP SER HIS PRO GLN PHE GLU LYS GLU ILE GLU LEU THR SEQRES 22 L 486 LEU THR GLN PRO ALA SER ALA SER ALA THR PRO GLY GLN SEQRES 23 L 486 ARG VAL THR ILE SER CYS SER GLY SER SER SER ASN ILE SEQRES 24 L 486 GLY GLY ASN THR VAL ASN TRP TYR GLN HIS LEU PRO GLY SEQRES 25 L 486 ALA ALA PRO LYS LEU LEU ILE HIS ASN ASN ASP LEU ARG SEQRES 26 L 486 PRO SER GLY VAL PRO ASP ARG PHE SER GLY SER LYS SER SEQRES 27 L 486 GLY THR SER ALA SER LEU ALA VAL SER GLY LEU GLN SER SEQRES 28 L 486 GLU ASP GLU ALA ASP TYR PHE CYS ALA ALA TRP ASP ASP SEQRES 29 L 486 GLY LEU ASN GLY TRP VAL PHE GLY GLY GLY THR LYS LEU SEQRES 30 L 486 THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 31 L 486 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 32 L 486 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 33 L 486 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 34 L 486 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 35 L 486 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 36 L 486 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 37 L 486 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 38 L 486 PRO THR GLU CYS SER FORMUL 13 HOH *7(H2 O) HELIX 1 AA1 PRO A 9 GLY A 20 1 12 HELIX 2 AA2 THR A 36 ALA A 44 1 9 HELIX 3 AA3 THR B 29 TYR B 33 5 5 HELIX 4 AA4 GLN B 63 GLN B 66 5 4 HELIX 5 AA5 THR B 88 THR B 92 5 5 HELIX 6 AA6 SER B 169 ALA B 171 5 3 HELIX 7 AA7 SER B 199 GLN B 205 1 7 HELIX 8 AA8 LYS B 214 ASN B 217 5 4 HELIX 9 AA9 PRO G 9 LEU G 19 1 11 HELIX 10 AB1 GLN C 82 GLU C 86 5 5 HELIX 11 AB2 SER C 127 ALA C 133 1 7 HELIX 12 AB3 THR C 187 HIS C 194 1 8 HELIX 13 AB4 PRO D 9 GLY D 20 1 12 HELIX 14 AB5 THR E 29 TYR E 33 5 5 HELIX 15 AB6 THR E 88 THR E 92 5 5 HELIX 16 AB7 SER E 169 ALA E 171 5 3 HELIX 17 AB8 SER E 200 GLY E 203 5 4 HELIX 18 AB9 LYS E 214 ASN E 217 5 4 HELIX 19 AC1 THR H 29 TYR H 33 5 5 HELIX 20 AC2 GLN H 63 GLN H 66 5 4 HELIX 21 AC3 THR H 88 THR H 92 5 5 HELIX 22 AC4 SER H 169 ALA H 171 5 3 HELIX 23 AC5 LYS H 214 SER H 216 5 3 HELIX 24 AC6 GLN I 82 GLU I 86 5 5 HELIX 25 AC7 SER I 127 ALA I 133 1 7 HELIX 26 AC8 THR I 187 HIS I 194 1 8 HELIX 27 AC9 GLN F 82 GLU F 86 5 5 HELIX 28 AD1 SER F 127 ALA F 133 1 7 HELIX 29 AD2 THR F 187 HIS F 194 1 8 HELIX 30 AD3 PRO J 9 GLY J 20 1 12 HELIX 31 AD4 THR J 36 ALA J 44 1 9 HELIX 32 AD5 THR K 29 TYR K 33 5 5 HELIX 33 AD6 GLN K 63 GLN K 66 5 4 HELIX 34 AD7 THR K 88 THR K 92 5 5 HELIX 35 AD8 SER K 169 ALA K 171 5 3 HELIX 36 AD9 SER K 200 GLY K 203 5 4 HELIX 37 AE1 LYS K 214 SER K 216 5 3 HELIX 38 AE2 GLN L 82 GLU L 86 5 5 HELIX 39 AE3 SER L 127 ALA L 133 1 7 HELIX 40 AE4 THR L 187 HIS L 194 1 8 SHEET 1 AA1 4 LEU B 4 GLN B 7 0 SHEET 2 AA1 4 VAL B 19 SER B 26 -1 O SER B 26 N LEU B 4 SHEET 3 AA1 4 THR B 79 LEU B 84 -1 O MET B 82 N VAL B 21 SHEET 4 AA1 4 VAL B 69 ASP B 74 -1 N ASP B 74 O THR B 79 SHEET 1 AA2 6 GLU B 11 LYS B 13 0 SHEET 2 AA2 6 THR B 120 VAL B 124 1 O THR B 123 N LYS B 13 SHEET 3 AA2 6 ALA B 93 ASP B 100 -1 N ALA B 93 O VAL B 122 SHEET 4 AA2 6 ALA B 34 GLN B 40 -1 N VAL B 38 O SER B 96 SHEET 5 AA2 6 LEU B 46 ILE B 52 -1 O GLU B 47 N ARG B 39 SHEET 6 AA2 6 ALA B 59 TYR B 61 -1 O LYS B 60 N TRP B 51 SHEET 1 AA3 4 GLU B 11 LYS B 13 0 SHEET 2 AA3 4 THR B 120 VAL B 124 1 O THR B 123 N LYS B 13 SHEET 3 AA3 4 ALA B 93 ASP B 100 -1 N ALA B 93 O VAL B 122 SHEET 4 AA3 4 LEU B 113 TRP B 116 -1 O ASP B 114 N ARG B 99 SHEET 1 AA4 4 SER B 133 LEU B 137 0 SHEET 2 AA4 4 THR B 148 TYR B 158 -1 O LEU B 154 N PHE B 135 SHEET 3 AA4 4 TYR B 189 PRO B 198 -1 O TYR B 189 N TYR B 158 SHEET 4 AA4 4 VAL B 176 THR B 178 -1 N HIS B 177 O VAL B 194 SHEET 1 AA5 4 SER B 133 LEU B 137 0 SHEET 2 AA5 4 THR B 148 TYR B 158 -1 O LEU B 154 N PHE B 135 SHEET 3 AA5 4 TYR B 189 PRO B 198 -1 O TYR B 189 N TYR B 158 SHEET 4 AA5 4 VAL B 182 LEU B 183 -1 N VAL B 182 O SER B 190 SHEET 1 AA6 3 THR B 164 TRP B 167 0 SHEET 2 AA6 3 TYR B 207 HIS B 213 -1 O ASN B 210 N SER B 166 SHEET 3 AA6 3 THR B 218 VAL B 224 -1 O THR B 218 N HIS B 213 SHEET 1 AA7 5 SER C 11 ALA C 14 0 SHEET 2 AA7 5 THR C 107 VAL C 111 1 O LYS C 108 N ALA C 12 SHEET 3 AA7 5 ALA C 87 ASP C 95 -1 N ALA C 87 O LEU C 109 SHEET 4 AA7 5 VAL C 36 HIS C 41 -1 N HIS C 41 O ASP C 88 SHEET 5 AA7 5 LYS C 48 ILE C 51 -1 O LYS C 48 N GLN C 40 SHEET 1 AA8 4 SER C 11 ALA C 14 0 SHEET 2 AA8 4 THR C 107 VAL C 111 1 O LYS C 108 N ALA C 12 SHEET 3 AA8 4 ALA C 87 ASP C 95 -1 N ALA C 87 O LEU C 109 SHEET 4 AA8 4 GLY C 100 PHE C 103 -1 O VAL C 102 N ALA C 93 SHEET 1 AA9 3 VAL C 20 SER C 25 0 SHEET 2 AA9 3 SER C 73 VAL C 78 -1 O VAL C 78 N VAL C 20 SHEET 3 AA9 3 PHE C 65 SER C 70 -1 N SER C 66 O ALA C 77 SHEET 1 AB1 4 SER C 120 PHE C 124 0 SHEET 2 AB1 4 ALA C 136 PHE C 145 -1 O SER C 143 N SER C 120 SHEET 3 AB1 4 TYR C 178 LEU C 186 -1 O ALA C 180 N ILE C 142 SHEET 4 AB1 4 VAL C 165 THR C 167 -1 N GLU C 166 O TYR C 183 SHEET 1 AB2 4 SER C 120 PHE C 124 0 SHEET 2 AB2 4 ALA C 136 PHE C 145 -1 O SER C 143 N SER C 120 SHEET 3 AB2 4 TYR C 178 LEU C 186 -1 O ALA C 180 N ILE C 142 SHEET 4 AB2 4 SER C 171 LYS C 172 -1 N SER C 171 O ALA C 179 SHEET 1 AB3 4 SER C 159 VAL C 161 0 SHEET 2 AB3 4 THR C 151 ALA C 156 -1 N ALA C 156 O SER C 159 SHEET 3 AB3 4 TYR C 197 HIS C 203 -1 O THR C 202 N THR C 151 SHEET 4 AB3 4 SER C 206 VAL C 212 -1 O SER C 206 N HIS C 203 SHEET 1 AB4 4 LEU E 4 GLN E 7 0 SHEET 2 AB4 4 VAL E 19 SER E 26 -1 O LYS E 24 N GLU E 6 SHEET 3 AB4 4 THR E 79 LEU E 84 -1 O MET E 82 N VAL E 21 SHEET 4 AB4 4 VAL E 69 ASP E 74 -1 N SER E 72 O TYR E 81 SHEET 1 AB5 6 GLU E 11 LYS E 13 0 SHEET 2 AB5 6 THR E 120 VAL E 124 1 O THR E 123 N LYS E 13 SHEET 3 AB5 6 ALA E 93 ASP E 100 -1 N TYR E 95 O THR E 120 SHEET 4 AB5 6 ALA E 34 GLN E 40 -1 N ALA E 34 O ASP E 100 SHEET 5 AB5 6 LEU E 46 ILE E 52 -1 O GLU E 47 N ARG E 39 SHEET 6 AB5 6 ALA E 59 TYR E 61 -1 O LYS E 60 N TRP E 51 SHEET 1 AB6 4 GLU E 11 LYS E 13 0 SHEET 2 AB6 4 THR E 120 VAL E 124 1 O THR E 123 N LYS E 13 SHEET 3 AB6 4 ALA E 93 ASP E 100 -1 N TYR E 95 O THR E 120 SHEET 4 AB6 4 LEU E 113 TRP E 116 -1 O PRO E 115 N ARG E 99 SHEET 1 AB7 4 SER E 133 LEU E 137 0 SHEET 2 AB7 4 THR E 148 TYR E 158 -1 O LEU E 154 N PHE E 135 SHEET 3 AB7 4 TYR E 189 PRO E 198 -1 O VAL E 197 N ALA E 149 SHEET 4 AB7 4 VAL E 176 THR E 178 -1 N HIS E 177 O VAL E 194 SHEET 1 AB8 4 SER E 133 LEU E 137 0 SHEET 2 AB8 4 THR E 148 TYR E 158 -1 O LEU E 154 N PHE E 135 SHEET 3 AB8 4 TYR E 189 PRO E 198 -1 O VAL E 197 N ALA E 149 SHEET 4 AB8 4 VAL E 182 LEU E 183 -1 N VAL E 182 O SER E 190 SHEET 1 AB9 3 THR E 164 TRP E 167 0 SHEET 2 AB9 3 ILE E 208 HIS E 213 -1 O ASN E 210 N SER E 166 SHEET 3 AB9 3 THR E 218 LYS E 223 -1 O VAL E 220 N VAL E 211 SHEET 1 AC1 4 LEU H 4 GLN H 7 0 SHEET 2 AC1 4 VAL H 19 SER H 26 -1 O LYS H 24 N GLU H 6 SHEET 3 AC1 4 THR H 79 LEU H 84 -1 O MET H 82 N VAL H 21 SHEET 4 AC1 4 VAL H 69 ASP H 74 -1 N ASP H 74 O THR H 79 SHEET 1 AC2 6 GLU H 11 LYS H 13 0 SHEET 2 AC2 6 THR H 120 VAL H 124 1 O THR H 123 N LYS H 13 SHEET 3 AC2 6 ALA H 93 ASP H 100 -1 N TYR H 95 O THR H 120 SHEET 4 AC2 6 ALA H 34 GLN H 40 -1 N ALA H 34 O ASP H 100 SHEET 5 AC2 6 LEU H 46 ILE H 52 -1 O GLU H 47 N ARG H 39 SHEET 6 AC2 6 ALA H 59 TYR H 61 -1 O LYS H 60 N TRP H 51 SHEET 1 AC3 4 GLU H 11 LYS H 13 0 SHEET 2 AC3 4 THR H 120 VAL H 124 1 O THR H 123 N LYS H 13 SHEET 3 AC3 4 ALA H 93 ASP H 100 -1 N TYR H 95 O THR H 120 SHEET 4 AC3 4 LEU H 113 TRP H 116 -1 O ASP H 114 N ARG H 99 SHEET 1 AC4 4 SER H 133 LEU H 137 0 SHEET 2 AC4 4 THR H 148 TYR H 158 -1 O LEU H 154 N PHE H 135 SHEET 3 AC4 4 TYR H 189 PRO H 198 -1 O TYR H 189 N TYR H 158 SHEET 4 AC4 4 VAL H 176 THR H 178 -1 N HIS H 177 O VAL H 194 SHEET 1 AC5 4 SER H 133 LEU H 137 0 SHEET 2 AC5 4 THR H 148 TYR H 158 -1 O LEU H 154 N PHE H 135 SHEET 3 AC5 4 TYR H 189 PRO H 198 -1 O TYR H 189 N TYR H 158 SHEET 4 AC5 4 VAL H 182 LEU H 183 -1 N VAL H 182 O SER H 190 SHEET 1 AC6 6 THR H 164 TRP H 167 0 SHEET 2 AC6 6 TYR H 207 HIS H 213 -1 O ASN H 210 N SER H 166 SHEET 3 AC6 6 THR H 218 VAL H 224 -1 O THR H 218 N HIS H 213 SHEET 4 AC6 6 THR K 218 LYS K 223 -1 O LYS K 219 N ASP H 221 SHEET 5 AC6 6 ILE K 208 HIS K 213 -1 N HIS K 213 O THR K 218 SHEET 6 AC6 6 THR K 164 TRP K 167 -1 N SER K 166 O ASN K 210 SHEET 1 AC7 5 SER I 11 ALA I 14 0 SHEET 2 AC7 5 THR I 107 VAL I 111 1 O LYS I 108 N ALA I 12 SHEET 3 AC7 5 ALA I 87 ASP I 95 -1 N TYR I 89 O THR I 107 SHEET 4 AC7 5 VAL I 36 HIS I 41 -1 N HIS I 41 O ASP I 88 SHEET 5 AC7 5 LYS I 48 ILE I 51 -1 O LYS I 48 N GLN I 40 SHEET 1 AC8 4 SER I 11 ALA I 14 0 SHEET 2 AC8 4 THR I 107 VAL I 111 1 O LYS I 108 N ALA I 12 SHEET 3 AC8 4 ALA I 87 ASP I 95 -1 N TYR I 89 O THR I 107 SHEET 4 AC8 4 GLY I 100 PHE I 103 -1 O GLY I 100 N ASP I 95 SHEET 1 AC9 3 VAL I 20 SER I 25 0 SHEET 2 AC9 3 SER I 73 VAL I 78 -1 O VAL I 78 N VAL I 20 SHEET 3 AC9 3 PHE I 65 SER I 70 -1 N SER I 70 O SER I 73 SHEET 1 AD1 4 SER I 120 PHE I 124 0 SHEET 2 AD1 4 ALA I 136 PHE I 145 -1 O SER I 143 N SER I 120 SHEET 3 AD1 4 TYR I 178 LEU I 186 -1 O SER I 182 N CYS I 140 SHEET 4 AD1 4 VAL I 165 THR I 167 -1 N GLU I 166 O TYR I 183 SHEET 1 AD2 4 SER I 120 PHE I 124 0 SHEET 2 AD2 4 ALA I 136 PHE I 145 -1 O SER I 143 N SER I 120 SHEET 3 AD2 4 TYR I 178 LEU I 186 -1 O SER I 182 N CYS I 140 SHEET 4 AD2 4 SER I 171 LYS I 172 -1 N SER I 171 O ALA I 179 SHEET 1 AD3 4 SER I 159 VAL I 161 0 SHEET 2 AD3 4 THR I 151 ALA I 156 -1 N ALA I 156 O SER I 159 SHEET 3 AD3 4 TYR I 197 HIS I 203 -1 O THR I 202 N THR I 151 SHEET 4 AD3 4 SER I 206 VAL I 212 -1 O VAL I 208 N VAL I 201 SHEET 1 AD4 5 SER F 11 ALA F 14 0 SHEET 2 AD4 5 THR F 107 VAL F 111 1 O LYS F 108 N ALA F 12 SHEET 3 AD4 5 ALA F 87 ASP F 95 -1 N ALA F 87 O LEU F 109 SHEET 4 AD4 5 ASN F 37 HIS F 41 -1 N HIS F 41 O ASP F 88 SHEET 5 AD4 5 LYS F 48 ILE F 51 -1 O LYS F 48 N GLN F 40 SHEET 1 AD5 4 SER F 11 ALA F 14 0 SHEET 2 AD5 4 THR F 107 VAL F 111 1 O LYS F 108 N ALA F 12 SHEET 3 AD5 4 ALA F 87 ASP F 95 -1 N ALA F 87 O LEU F 109 SHEET 4 AD5 4 GLY F 100 PHE F 103 -1 O GLY F 100 N ASP F 95 SHEET 1 AD6 3 VAL F 20 SER F 25 0 SHEET 2 AD6 3 SER F 73 VAL F 78 -1 O LEU F 76 N ILE F 22 SHEET 3 AD6 3 PHE F 65 SER F 70 -1 N SER F 66 O ALA F 77 SHEET 1 AD7 4 SER F 120 PHE F 124 0 SHEET 2 AD7 4 ALA F 136 PHE F 145 -1 O LEU F 141 N THR F 122 SHEET 3 AD7 4 TYR F 178 LEU F 186 -1 O ALA F 180 N ILE F 142 SHEET 4 AD7 4 VAL F 165 THR F 167 -1 N GLU F 166 O TYR F 183 SHEET 1 AD8 4 SER F 120 PHE F 124 0 SHEET 2 AD8 4 ALA F 136 PHE F 145 -1 O LEU F 141 N THR F 122 SHEET 3 AD8 4 TYR F 178 LEU F 186 -1 O ALA F 180 N ILE F 142 SHEET 4 AD8 4 SER F 171 LYS F 172 -1 N SER F 171 O ALA F 179 SHEET 1 AD9 4 SER F 159 VAL F 161 0 SHEET 2 AD9 4 THR F 151 ALA F 156 -1 N ALA F 156 O SER F 159 SHEET 3 AD9 4 TYR F 197 HIS F 203 -1 O GLN F 200 N ALA F 153 SHEET 4 AD9 4 SER F 206 VAL F 212 -1 O SER F 206 N HIS F 203 SHEET 1 AE1 4 LEU K 4 GLN K 7 0 SHEET 2 AE1 4 VAL K 19 SER K 26 -1 O LYS K 24 N GLU K 6 SHEET 3 AE1 4 THR K 79 LEU K 84 -1 O MET K 82 N VAL K 21 SHEET 4 AE1 4 VAL K 69 ASP K 74 -1 N ILE K 70 O GLU K 83 SHEET 1 AE2 6 GLU K 11 LYS K 13 0 SHEET 2 AE2 6 THR K 120 VAL K 124 1 O THR K 123 N LYS K 13 SHEET 3 AE2 6 ALA K 93 ASP K 100 -1 N ALA K 93 O VAL K 122 SHEET 4 AE2 6 ALA K 34 GLN K 40 -1 N HIS K 36 O ALA K 98 SHEET 5 AE2 6 LEU K 46 ILE K 52 -1 O GLU K 47 N ARG K 39 SHEET 6 AE2 6 ALA K 59 TYR K 61 -1 O LYS K 60 N TRP K 51 SHEET 1 AE3 4 GLU K 11 LYS K 13 0 SHEET 2 AE3 4 THR K 120 VAL K 124 1 O THR K 123 N LYS K 13 SHEET 3 AE3 4 ALA K 93 ASP K 100 -1 N ALA K 93 O VAL K 122 SHEET 4 AE3 4 LEU K 113 TRP K 116 -1 O ASP K 114 N ARG K 99 SHEET 1 AE4 4 SER K 133 LEU K 137 0 SHEET 2 AE4 4 THR K 148 TYR K 158 -1 O GLY K 152 N LEU K 137 SHEET 3 AE4 4 TYR K 189 PRO K 198 -1 O TYR K 189 N TYR K 158 SHEET 4 AE4 4 VAL K 176 THR K 178 -1 N HIS K 177 O VAL K 194 SHEET 1 AE5 4 SER K 133 LEU K 137 0 SHEET 2 AE5 4 THR K 148 TYR K 158 -1 O GLY K 152 N LEU K 137 SHEET 3 AE5 4 TYR K 189 PRO K 198 -1 O TYR K 189 N TYR K 158 SHEET 4 AE5 4 VAL K 182 LEU K 183 -1 N VAL K 182 O SER K 190 SHEET 1 AE6 5 SER L 11 ALA L 14 0 SHEET 2 AE6 5 THR L 107 VAL L 111 1 O LYS L 108 N ALA L 12 SHEET 3 AE6 5 ALA L 87 ASP L 95 -1 N ALA L 87 O LEU L 109 SHEET 4 AE6 5 ASN L 37 HIS L 41 -1 N HIS L 41 O ASP L 88 SHEET 5 AE6 5 LYS L 48 ILE L 51 -1 O LYS L 48 N GLN L 40 SHEET 1 AE7 4 SER L 11 ALA L 14 0 SHEET 2 AE7 4 THR L 107 VAL L 111 1 O LYS L 108 N ALA L 12 SHEET 3 AE7 4 ALA L 87 ASP L 95 -1 N ALA L 87 O LEU L 109 SHEET 4 AE7 4 GLY L 100 PHE L 103 -1 O GLY L 100 N ASP L 95 SHEET 1 AE8 3 VAL L 20 SER L 25 0 SHEET 2 AE8 3 SER L 73 VAL L 78 -1 O VAL L 78 N VAL L 20 SHEET 3 AE8 3 PHE L 65 SER L 70 -1 N SER L 70 O SER L 73 SHEET 1 AE9 4 SER L 120 PHE L 124 0 SHEET 2 AE9 4 ALA L 136 PHE L 145 -1 O SER L 143 N SER L 120 SHEET 3 AE9 4 TYR L 178 LEU L 186 -1 O ALA L 180 N ILE L 142 SHEET 4 AE9 4 VAL L 165 THR L 167 -1 N GLU L 166 O TYR L 183 SHEET 1 AF1 4 SER L 120 PHE L 124 0 SHEET 2 AF1 4 ALA L 136 PHE L 145 -1 O SER L 143 N SER L 120 SHEET 3 AF1 4 TYR L 178 LEU L 186 -1 O ALA L 180 N ILE L 142 SHEET 4 AF1 4 SER L 171 LYS L 172 -1 N SER L 171 O ALA L 179 SHEET 1 AF2 4 SER L 159 VAL L 161 0 SHEET 2 AF2 4 THR L 151 ALA L 156 -1 N ALA L 156 O SER L 159 SHEET 3 AF2 4 TYR L 197 HIS L 203 -1 O THR L 202 N THR L 151 SHEET 4 AF2 4 SER L 206 VAL L 212 -1 O VAL L 208 N VAL L 201 SSBOND 1 CYS B 23 CYS B 97 1555 1555 2.03 SSBOND 2 CYS B 153 CYS B 209 1555 1555 2.03 SSBOND 3 CYS C 24 CYS C 91 1555 1555 2.03 SSBOND 4 CYS C 140 CYS C 199 1555 1555 2.03 SSBOND 5 CYS E 23 CYS E 97 1555 1555 2.04 SSBOND 6 CYS E 153 CYS E 209 1555 1555 2.03 SSBOND 7 CYS H 23 CYS H 97 1555 1555 2.03 SSBOND 8 CYS H 153 CYS H 209 1555 1555 2.03 SSBOND 9 CYS I 24 CYS I 91 1555 1555 2.03 SSBOND 10 CYS I 140 CYS I 199 1555 1555 2.03 SSBOND 11 CYS F 24 CYS F 91 1555 1555 2.03 SSBOND 12 CYS F 140 CYS F 199 1555 1555 2.03 SSBOND 13 CYS K 23 CYS K 97 1555 1555 2.04 SSBOND 14 CYS K 153 CYS K 209 1555 1555 2.03 SSBOND 15 CYS L 24 CYS L 91 1555 1555 2.03 SSBOND 16 CYS L 140 CYS L 199 1555 1555 2.03 CISPEP 1 ASP B 114 PRO B 115 0 -4.86 CISPEP 2 PHE B 159 PRO B 160 0 -6.68 CISPEP 3 GLU B 161 PRO B 162 0 -5.63 CISPEP 4 TYR C 146 PRO C 147 0 -0.24 CISPEP 5 ASP E 114 PRO E 115 0 -2.07 CISPEP 6 PHE E 159 PRO E 160 0 -6.47 CISPEP 7 GLU E 161 PRO E 162 0 -2.98 CISPEP 8 ASP H 114 PRO H 115 0 -4.99 CISPEP 9 PHE H 159 PRO H 160 0 -6.81 CISPEP 10 GLU H 161 PRO H 162 0 -5.39 CISPEP 11 TYR I 146 PRO I 147 0 -0.41 CISPEP 12 TYR F 146 PRO F 147 0 6.94 CISPEP 13 ASP K 114 PRO K 115 0 -3.69 CISPEP 14 PHE K 159 PRO K 160 0 -6.61 CISPEP 15 GLU K 161 PRO K 162 0 -3.50 CISPEP 16 TYR L 146 PRO L 147 0 7.61 CRYST1 72.320 121.760 234.100 90.00 90.00 90.00 P 21 21 21 32 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.013827 0.000000 0.000000 0.00000 SCALE2 0.000000 0.008213 0.000000 0.00000 SCALE3 0.000000 0.000000 0.004272 0.00000 MTRIX1 1 -0.999939 -0.008476 0.007148 0.71987 1 MTRIX2 1 -0.008468 0.999964 0.001096 -0.52747 1 MTRIX3 1 -0.007157 0.001035 -0.999974 -120.90935 1 MTRIX1 2 -0.999840 -0.014406 -0.010625 -0.77579 1 MTRIX2 2 -0.014476 0.999874 0.006556 -0.25157 1 MTRIX3 2 0.010530 0.006709 -0.999922 -120.61538 1 MTRIX1 3 0.999221 0.038621 0.008146 36.83419 1 MTRIX2 3 0.038630 -0.999253 -0.000925 0.73229 1 MTRIX3 3 0.008104 0.001239 -0.999966 -3.79188 1 MTRIX1 4 0.999932 0.010567 0.005028 36.03659 1 MTRIX2 4 0.010586 -0.999937 -0.003727 -0.17183 1 MTRIX3 4 0.004988 0.003780 -0.999980 -3.66578 1 MTRIX1 5 0.999712 0.023124 -0.006478 36.02108 1 MTRIX2 5 0.023091 -0.999721 -0.005014 0.06063 1 MTRIX3 5 -0.006592 0.004863 -0.999966 -3.98074 1 MTRIX1 6 -0.258794 0.574806 0.776289 79.01507 1 MTRIX2 6 0.476299 0.775108 -0.415146 56.35008 1 MTRIX3 6 -0.840336 0.262308 -0.474373 18.20970 1