HEADER VIRAL PROTEIN/IMMUNE SYSTEM 09-JUN-23 8T4D TITLE MD65 N332-GT5 SOSIP IN COMPLEX WITH RM_N332_08 FAB AND RM20A3 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: MD65 N332-GT5 SOSIP GP120; COMPND 3 CHAIN: A, E, F; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: RM20A3 HEAVY CHAIN FV; COMPND 7 CHAIN: C, J, K; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: RM20A3 LIGHT CHAIN FV; COMPND 11 CHAIN: D, M, N; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: MD65 N332-GT5 SOSIP GP41; COMPND 15 CHAIN: B, G, I; COMPND 16 ENGINEERED: YES; COMPND 17 MOL_ID: 5; COMPND 18 MOLECULE: RM_N332_08 HEAVY CHAIN FV; COMPND 19 CHAIN: H, O, P; COMPND 20 ENGINEERED: YES; COMPND 21 MOL_ID: 6; COMPND 22 MOLECULE: RM_N332_08 LIGHT CHAIN FV; COMPND 23 CHAIN: L, Q, R; COMPND 24 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 8 ORGANISM_TAXID: 9544; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 13 ORGANISM_TAXID: 9544; SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 MOL_ID: 4; SOURCE 17 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 18 ORGANISM_TAXID: 11676; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 21 MOL_ID: 5; SOURCE 22 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 23 ORGANISM_TAXID: 9544; SOURCE 24 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 25 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 26 MOL_ID: 6; SOURCE 27 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 28 ORGANISM_TAXID: 9544; SOURCE 29 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 30 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS GERMLINE TARGETING, NHP, SOSIP, ENV, HIV, BG18, IMMUNOGEN DESIGN, KEYWDS 2 ANTIBODY, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.OZOROWSKI,J.L.TORRES,A.B.WARD JRNL AUTH J.M.STEICHEN,I.PHUNG JRNL TITL VACCINE PRIMING OF RARE HIV BROADLY NEUTRALIZING ANTIBODY JRNL TITL 2 PRECURSORS IN NONHUMAN PRIMATES JRNL REF SCIENCE 2024 JRNL REFN ESSN 1095-9203 JRNL DOI 10.1126/SCIENCE.ADJ8321 REMARK 2 REMARK 2 RESOLUTION. 3.10 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : EPU, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.100 REMARK 3 NUMBER OF PARTICLES : 99087 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8T4D COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB. REMARK 100 THE DEPOSITION ID IS D_1000275183. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : MD65 N332-GT5 SOSIP IN COMPLEX REMARK 245 WITH RM_N332_08 FAB AND RM20A3 REMARK 245 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 5.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 50.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, D, B, H, L, E, J, M, G, REMARK 350 AND CHAINS: O, Q, F, K, N, I, P, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA A 31 REMARK 465 GLU A 32 REMARK 465 ALA A 58 REMARK 465 LYS A 59 REMARK 465 ALA A 60 REMARK 465 TYR A 61 REMARK 465 GLU A 62 REMARK 465 THR A 63 REMARK 465 GLU A 64 REMARK 465 LYS A 65 REMARK 465 GLU A 185A REMARK 465 ASN A 185B REMARK 465 GLN A 185C REMARK 465 GLY A 185D REMARK 465 ASN A 185E REMARK 465 ARG A 185F REMARK 465 SER A 185G REMARK 465 ASN A 185H REMARK 465 ASN A 185I REMARK 465 SER A 185J REMARK 465 ASN A 399 REMARK 465 THR A 400 REMARK 465 SER A 401 REMARK 465 VAL A 402 REMARK 465 GLN A 403 REMARK 465 GLY A 404 REMARK 465 SER A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 THR A 408 REMARK 465 GLY A 409 REMARK 465 SER A 410 REMARK 465 ASN A 411 REMARK 465 GLY A 458 REMARK 465 GLY A 459 REMARK 465 SER A 460 REMARK 465 THR A 461 REMARK 465 ASN A 462 REMARK 465 THR A 505 REMARK 465 VAL A 506 REMARK 465 GLY A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 SER C 112 REMARK 465 SER C 113 REMARK 465 THR D 105 REMARK 465 VAL D 106 REMARK 465 LEU D 107 REMARK 465 GLY D 108 REMARK 465 GLN D 109 REMARK 465 PRO D 110 REMARK 465 LYS D 111 REMARK 465 ALA D 112 REMARK 465 SER D 113 REMARK 465 PRO D 114 REMARK 465 THR D 115 REMARK 465 VAL D 116 REMARK 465 THR D 117 REMARK 465 LEU D 118 REMARK 465 PHE D 119 REMARK 465 PRO D 120 REMARK 465 PRO D 121 REMARK 465 SER D 122 REMARK 465 SER D 123 REMARK 465 GLU D 124 REMARK 465 GLU D 125 REMARK 465 LEU D 126 REMARK 465 ALA B 512 REMARK 465 ALA B 513 REMARK 465 GLY B 514 REMARK 465 ILE B 515 REMARK 465 GLY B 516 REMARK 465 ALA B 517 REMARK 465 SER B 518 REMARK 465 SER B 519 REMARK 465 ASP B 520 REMARK 465 GLY B 547 REMARK 465 ILE B 548 REMARK 465 VAL B 549 REMARK 465 GLN B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 SER B 553 REMARK 465 ASN B 554 REMARK 465 LEU B 555 REMARK 465 LEU B 556 REMARK 465 ARG B 557 REMARK 465 ALA B 558 REMARK 465 PRO B 559 REMARK 465 GLU B 560 REMARK 465 PRO B 561 REMARK 465 GLN B 562 REMARK 465 GLN B 563 REMARK 465 HIS B 564 REMARK 465 LEU B 565 REMARK 465 LEU B 566 REMARK 465 LYS B 567 REMARK 465 ASP B 568 REMARK 465 THR B 569 REMARK 465 HIS B 570 REMARK 465 TRP B 571 REMARK 465 SER H 113 REMARK 465 ASP L 1 REMARK 465 GLU L 105 REMARK 465 ILE L 106 REMARK 465 LYS L 107 REMARK 465 ALA E 31 REMARK 465 GLU E 32 REMARK 465 ALA E 58 REMARK 465 LYS E 59 REMARK 465 ALA E 60 REMARK 465 TYR E 61 REMARK 465 GLU E 62 REMARK 465 THR E 63 REMARK 465 GLU E 64 REMARK 465 LYS E 65 REMARK 465 GLU E 185A REMARK 465 ASN E 185B REMARK 465 GLN E 185C REMARK 465 GLY E 185D REMARK 465 ASN E 185E REMARK 465 ARG E 185F REMARK 465 SER E 185G REMARK 465 ASN E 185H REMARK 465 ASN E 185I REMARK 465 SER E 185J REMARK 465 ASN E 399 REMARK 465 THR E 400 REMARK 465 SER E 401 REMARK 465 VAL E 402 REMARK 465 GLN E 403 REMARK 465 GLY E 404 REMARK 465 SER E 405 REMARK 465 ASN E 406 REMARK 465 SER E 407 REMARK 465 THR E 408 REMARK 465 GLY E 409 REMARK 465 SER E 410 REMARK 465 ASN E 411 REMARK 465 GLY E 458 REMARK 465 GLY E 459 REMARK 465 SER E 460 REMARK 465 THR E 461 REMARK 465 ASN E 462 REMARK 465 THR E 505 REMARK 465 VAL E 506 REMARK 465 GLY E 507 REMARK 465 ARG E 508 REMARK 465 ARG E 509 REMARK 465 ARG E 510 REMARK 465 ARG E 511 REMARK 465 ARG E 512 REMARK 465 ARG E 513 REMARK 465 SER J 112 REMARK 465 SER J 113 REMARK 465 THR M 105 REMARK 465 VAL M 106 REMARK 465 LEU M 107 REMARK 465 GLY M 108 REMARK 465 GLN M 109 REMARK 465 PRO M 110 REMARK 465 LYS M 111 REMARK 465 ALA M 112 REMARK 465 SER M 113 REMARK 465 PRO M 114 REMARK 465 THR M 115 REMARK 465 VAL M 116 REMARK 465 THR M 117 REMARK 465 LEU M 118 REMARK 465 PHE M 119 REMARK 465 PRO M 120 REMARK 465 PRO M 121 REMARK 465 SER M 122 REMARK 465 SER M 123 REMARK 465 GLU M 124 REMARK 465 GLU M 125 REMARK 465 LEU M 126 REMARK 465 ALA G 512 REMARK 465 ALA G 513 REMARK 465 GLY G 514 REMARK 465 ILE G 515 REMARK 465 GLY G 516 REMARK 465 ALA G 517 REMARK 465 SER G 518 REMARK 465 SER G 519 REMARK 465 ASP G 520 REMARK 465 GLY G 547 REMARK 465 ILE G 548 REMARK 465 VAL G 549 REMARK 465 GLN G 550 REMARK 465 GLN G 551 REMARK 465 GLN G 552 REMARK 465 SER G 553 REMARK 465 ASN G 554 REMARK 465 LEU G 555 REMARK 465 LEU G 556 REMARK 465 ARG G 557 REMARK 465 ALA G 558 REMARK 465 PRO G 559 REMARK 465 GLU G 560 REMARK 465 PRO G 561 REMARK 465 GLN G 562 REMARK 465 GLN G 563 REMARK 465 HIS G 564 REMARK 465 LEU G 565 REMARK 465 LEU G 566 REMARK 465 LYS G 567 REMARK 465 ASP G 568 REMARK 465 THR G 569 REMARK 465 HIS G 570 REMARK 465 TRP G 571 REMARK 465 SER O 113 REMARK 465 ASP Q 1 REMARK 465 GLU Q 105 REMARK 465 ILE Q 106 REMARK 465 LYS Q 107 REMARK 465 ALA F 31 REMARK 465 GLU F 32 REMARK 465 ALA F 58 REMARK 465 LYS F 59 REMARK 465 ALA F 60 REMARK 465 TYR F 61 REMARK 465 GLU F 62 REMARK 465 THR F 63 REMARK 465 GLU F 64 REMARK 465 LYS F 65 REMARK 465 GLU F 185A REMARK 465 ASN F 185B REMARK 465 GLN F 185C REMARK 465 GLY F 185D REMARK 465 ASN F 185E REMARK 465 ARG F 185F REMARK 465 SER F 185G REMARK 465 ASN F 185H REMARK 465 ASN F 185I REMARK 465 SER F 185J REMARK 465 ASN F 399 REMARK 465 THR F 400 REMARK 465 SER F 401 REMARK 465 VAL F 402 REMARK 465 GLN F 403 REMARK 465 GLY F 404 REMARK 465 SER F 405 REMARK 465 ASN F 406 REMARK 465 SER F 407 REMARK 465 THR F 408 REMARK 465 GLY F 409 REMARK 465 SER F 410 REMARK 465 ASN F 411 REMARK 465 GLY F 458 REMARK 465 GLY F 459 REMARK 465 SER F 460 REMARK 465 THR F 461 REMARK 465 ASN F 462 REMARK 465 THR F 505 REMARK 465 VAL F 506 REMARK 465 GLY F 507 REMARK 465 ARG F 508 REMARK 465 ARG F 509 REMARK 465 ARG F 510 REMARK 465 ARG F 511 REMARK 465 ARG F 512 REMARK 465 ARG F 513 REMARK 465 SER K 112 REMARK 465 SER K 113 REMARK 465 THR N 105 REMARK 465 VAL N 106 REMARK 465 LEU N 107 REMARK 465 GLY N 108 REMARK 465 GLN N 109 REMARK 465 PRO N 110 REMARK 465 LYS N 111 REMARK 465 ALA N 112 REMARK 465 SER N 113 REMARK 465 PRO N 114 REMARK 465 THR N 115 REMARK 465 VAL N 116 REMARK 465 THR N 117 REMARK 465 LEU N 118 REMARK 465 PHE N 119 REMARK 465 PRO N 120 REMARK 465 PRO N 121 REMARK 465 SER N 122 REMARK 465 SER N 123 REMARK 465 GLU N 124 REMARK 465 GLU N 125 REMARK 465 LEU N 126 REMARK 465 ALA I 512 REMARK 465 ALA I 513 REMARK 465 GLY I 514 REMARK 465 ILE I 515 REMARK 465 GLY I 516 REMARK 465 ALA I 517 REMARK 465 SER I 518 REMARK 465 SER I 519 REMARK 465 ASP I 520 REMARK 465 GLY I 547 REMARK 465 ILE I 548 REMARK 465 VAL I 549 REMARK 465 GLN I 550 REMARK 465 GLN I 551 REMARK 465 GLN I 552 REMARK 465 SER I 553 REMARK 465 ASN I 554 REMARK 465 LEU I 555 REMARK 465 LEU I 556 REMARK 465 ARG I 557 REMARK 465 ALA I 558 REMARK 465 PRO I 559 REMARK 465 GLU I 560 REMARK 465 PRO I 561 REMARK 465 GLN I 562 REMARK 465 GLN I 563 REMARK 465 HIS I 564 REMARK 465 LEU I 565 REMARK 465 LEU I 566 REMARK 465 LYS I 567 REMARK 465 ASP I 568 REMARK 465 THR I 569 REMARK 465 HIS I 570 REMARK 465 TRP I 571 REMARK 465 SER P 113 REMARK 465 ASP R 1 REMARK 465 GLU R 105 REMARK 465 ILE R 106 REMARK 465 LYS R 107 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 NH1 ARG E 151 OE2 GLU O 97 2.01 REMARK 500 NH1 ARG A 151 OE2 GLU H 97 2.07 REMARK 500 NH1 ARG F 151 OE2 GLU P 97 2.07 REMARK 500 O GLY C 96 OH TYR D 96 2.16 REMARK 500 O GLY K 96 OH TYR N 96 2.16 REMARK 500 O GLY J 96 OH TYR M 96 2.16 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA A 135 70.38 53.22 REMARK 500 SER A 140 22.07 -148.90 REMARK 500 MET A 141 11.72 51.23 REMARK 500 GLN A 258 -54.48 66.14 REMARK 500 ASN A 392 71.25 -157.76 REMARK 500 LEU C 82C 108.18 -34.96 REMARK 500 SER C 99 59.65 -91.87 REMARK 500 ALA C 100 -38.99 64.82 REMARK 500 LYS C 100E -90.53 -109.48 REMARK 500 ASP D 50 -175.54 64.18 REMARK 500 SER B 612 -15.00 81.39 REMARK 500 LEU L 9 53.10 70.79 REMARK 500 VAL L 51 -61.73 58.86 REMARK 500 SER L 67 167.61 172.05 REMARK 500 THR L 69 -24.55 87.01 REMARK 500 GLN L 90 79.41 -110.84 REMARK 500 ALA E 135 70.37 53.23 REMARK 500 SER E 140 22.03 -148.90 REMARK 500 MET E 141 11.67 51.27 REMARK 500 GLN E 258 -54.48 66.14 REMARK 500 ASN E 392 71.24 -157.74 REMARK 500 LEU J 82C 108.16 -34.91 REMARK 500 SER J 99 59.63 -91.90 REMARK 500 ALA J 100 -38.98 64.82 REMARK 500 LYS J 100E -90.52 -109.50 REMARK 500 ASP M 50 -175.53 64.19 REMARK 500 SER G 612 -15.00 81.39 REMARK 500 LEU Q 9 53.13 70.74 REMARK 500 VAL Q 51 -61.70 58.83 REMARK 500 SER Q 67 167.60 172.03 REMARK 500 THR Q 69 -24.57 87.05 REMARK 500 GLN Q 90 79.43 -110.85 REMARK 500 ALA F 135 70.34 53.26 REMARK 500 SER F 140 22.08 -148.91 REMARK 500 MET F 141 11.72 51.22 REMARK 500 GLN F 258 -54.46 66.13 REMARK 500 ASN F 392 71.23 -157.77 REMARK 500 LEU K 82C 108.19 -34.97 REMARK 500 SER K 99 59.65 -91.91 REMARK 500 ALA K 100 -38.99 64.82 REMARK 500 LYS K 100E -90.55 -109.50 REMARK 500 ASP N 50 -175.49 64.21 REMARK 500 SER I 612 -14.99 81.38 REMARK 500 LEU R 9 53.11 70.75 REMARK 500 VAL R 51 -61.73 58.88 REMARK 500 SER R 67 167.58 172.04 REMARK 500 THR R 69 -24.53 87.02 REMARK 500 GLN R 90 79.42 -110.85 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-41027 RELATED DB: EMDB REMARK 900 MD65 N332-GT5 SOSIP IN COMPLEX WITH RM_N332_08 FAB AND RM20A3 FAB DBREF 8T4D A 31 513 PDB 8T4D 8T4D 31 513 DBREF 8T4D C 1 113 PDB 8T4D 8T4D 1 113 DBREF 8T4D D 3 126 PDB 8T4D 8T4D 3 126 DBREF 8T4D B 512 664 PDB 8T4D 8T4D 512 664 DBREF 8T4D H 1 113 PDB 8T4D 8T4D 1 113 DBREF 8T4D L 1 107 PDB 8T4D 8T4D 1 107 DBREF 8T4D E 31 513 PDB 8T4D 8T4D 31 513 DBREF 8T4D J 1 113 PDB 8T4D 8T4D 1 113 DBREF 8T4D M 3 126 PDB 8T4D 8T4D 3 126 DBREF 8T4D G 512 664 PDB 8T4D 8T4D 512 664 DBREF 8T4D O 1 113 PDB 8T4D 8T4D 1 113 DBREF 8T4D Q 1 107 PDB 8T4D 8T4D 1 107 DBREF 8T4D F 31 513 PDB 8T4D 8T4D 31 513 DBREF 8T4D K 1 113 PDB 8T4D 8T4D 1 113 DBREF 8T4D N 3 126 PDB 8T4D 8T4D 3 126 DBREF 8T4D I 512 664 PDB 8T4D 8T4D 512 664 DBREF 8T4D P 1 113 PDB 8T4D 8T4D 1 113 DBREF 8T4D R 1 107 PDB 8T4D 8T4D 1 107 SEQRES 1 A 481 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 A 481 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 A 481 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 A 481 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 A 481 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 A 481 TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP ILE SEQRES 7 A 481 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 A 481 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN TYR SEQRES 9 A 481 ALA PRO LYS LEU ARG SER MET MET ARG GLY GLU ILE LYS SEQRES 10 A 481 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 A 481 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 A 481 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 A 481 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 A 481 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 A 481 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 A 481 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 A 481 CYS GLN ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 A 481 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 A 481 LEU ALA GLU GLU GLU VAL ILE ILE ARG SER GLU ASN ILE SEQRES 20 A 481 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN LEU ASN THR SEQRES 21 A 481 SER VAL GLN ILE ASN CYS THR ARG PRO SER ASN ASN THR SEQRES 22 A 481 VAL LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 A 481 TYR PHE GLY ASP VAL LEU GLY HIS VAL ARG MET ALA HIS SEQRES 24 A 481 CYS ASN ILE SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 A 481 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 A 481 THR ILE ILE ARG PHE ALA GLN SER SER GLY GLY ASP LEU SEQRES 27 A 481 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 A 481 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 A 481 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 A 481 SER ASN ASP SER LEU ILE LEU PRO CYS TRP ILE LYS GLN SEQRES 31 A 481 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR SEQRES 32 A 481 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 A 481 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 A 481 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 A 481 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 A 481 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 A 481 CYS LYS ARG ARG THR VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 C 125 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY LEU VAL GLN SEQRES 2 C 125 PRO GLY GLY SER LEU LYS LEU SER CYS ARG ALA SER GLY SEQRES 3 C 125 TYR THR PHE SER SER PHE ALA MET SER TRP VAL ARG GLN SEQRES 4 C 125 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER LEU ILE ASN SEQRES 5 C 125 ASP ARG GLY GLY LEU THR PHE TYR VAL ASP SER VAL LYS SEQRES 6 C 125 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 C 125 LEU SER LEU GLN MET HIS SER LEU ARG ASP GLY ASP THR SEQRES 8 C 125 ALA VAL TYR TYR CYS ALA THR GLY GLY MET SER SER ALA SEQRES 9 C 125 LEU GLN SER SER LYS TYR TYR PHE ASP PHE TRP GLY GLN SEQRES 10 C 125 GLY ALA LEU VAL THR VAL SER SER SEQRES 1 D 128 ALA LEU THR GLN PRO PRO SER VAL SER GLY SER PRO GLY SEQRES 2 D 128 GLN SER VAL THR ILE SER CYS THR GLY THR SER SER ASP SEQRES 3 D 128 ILE GLY SER TYR ASN TYR VAL SER TRP TYR GLN GLN HIS SEQRES 4 D 128 PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP VAL THR SEQRES 5 D 128 GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SER SEQRES 6 D 128 LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY LEU SEQRES 7 D 128 GLN ALA ASP ASP GLU ALA ASP TYR TYR CYS SER ALA TYR SEQRES 8 D 128 ALA GLY ARG GLN THR PHE TYR ILE PHE GLY GLY GLY THR SEQRES 9 D 128 ARG LEU THR VAL LEU GLY GLN PRO LYS ALA SER PRO THR SEQRES 10 D 128 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 1 B 153 ALA ALA GLY ILE GLY ALA SER SER ASP GLY PHE LEU GLY SEQRES 2 B 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 B 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU PRO GLN GLN SEQRES 5 B 153 HIS LEU LEU LYS ASP THR HIS TRP GLY ILE LYS GLN LEU SEQRES 6 B 153 GLN ALA ARG VAL LEU ALA VAL GLU HIS TYR LEU ARG ASP SEQRES 7 B 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 B 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 B 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 B 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 B 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 B 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 H 130 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 130 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 H 130 TYR THR PHE THR ASP HIS TYR ILE HIS TRP VAL ARG GLN SEQRES 4 H 130 ALA PRO ARG GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 H 130 PRO TYR ASN GLY ASN THR ASN TYR ALA GLN LYS PHE GLN SEQRES 6 H 130 GLY ARG VAL THR LEU THR ARG ASP THR SER THR THR THR SEQRES 7 H 130 VAL TYR MET GLU LEU ILE SER LEU ARG SER GLU ASP THR SEQRES 8 H 130 ALA VAL TYR TYR CYS ALA ARG GLY GLY GLU TYR CYS THR SEQRES 9 H 130 GLY PHE GLY CYS PHE ALA GLY LYS GLY ASP ASN SER LEU SEQRES 10 H 130 ASP VAL TRP GLY ARG GLY VAL LEU VAL SER VAL SER SER SEQRES 1 L 113 ASP ILE VAL MET ILE GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 L 113 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 L 113 GLN SER LEU PHE ASP ILE GLU ASP GLU THR THR TYR LEU SEQRES 4 L 113 GLU TRP PHE LEU GLN LYS PRO GLY GLN SER PRO GLN PRO SEQRES 5 L 113 LEU ILE TYR GLU VAL SER ASN ARG ALA SER GLY VAL PRO SEQRES 6 L 113 ASP ARG PHE SER GLY SER GLY SER ASP THR ALA PHE THR SEQRES 7 L 113 LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY ILE SEQRES 8 L 113 TYR TYR CYS MET GLN GLY ILE GLU TYR PRO PHE THR PHE SEQRES 9 L 113 GLY PRO GLY THR LYS VAL GLU ILE LYS SEQRES 1 E 481 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 E 481 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 E 481 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 E 481 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 E 481 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 E 481 TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP ILE SEQRES 7 E 481 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 E 481 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN TYR SEQRES 9 E 481 ALA PRO LYS LEU ARG SER MET MET ARG GLY GLU ILE LYS SEQRES 10 E 481 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 E 481 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 E 481 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 E 481 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 E 481 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 E 481 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 E 481 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 E 481 CYS GLN ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 E 481 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 E 481 LEU ALA GLU GLU GLU VAL ILE ILE ARG SER GLU ASN ILE SEQRES 20 E 481 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN LEU ASN THR SEQRES 21 E 481 SER VAL GLN ILE ASN CYS THR ARG PRO SER ASN ASN THR SEQRES 22 E 481 VAL LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 E 481 TYR PHE GLY ASP VAL LEU GLY HIS VAL ARG MET ALA HIS SEQRES 24 E 481 CYS ASN ILE SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 E 481 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 E 481 THR ILE ILE ARG PHE ALA GLN SER SER GLY GLY ASP LEU SEQRES 27 E 481 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 E 481 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 E 481 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 E 481 SER ASN ASP SER LEU ILE LEU PRO CYS TRP ILE LYS GLN SEQRES 31 E 481 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR SEQRES 32 E 481 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 E 481 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 E 481 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 E 481 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 E 481 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 E 481 CYS LYS ARG ARG THR VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 J 125 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY LEU VAL GLN SEQRES 2 J 125 PRO GLY GLY SER LEU LYS LEU SER CYS ARG ALA SER GLY SEQRES 3 J 125 TYR THR PHE SER SER PHE ALA MET SER TRP VAL ARG GLN SEQRES 4 J 125 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER LEU ILE ASN SEQRES 5 J 125 ASP ARG GLY GLY LEU THR PHE TYR VAL ASP SER VAL LYS SEQRES 6 J 125 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 J 125 LEU SER LEU GLN MET HIS SER LEU ARG ASP GLY ASP THR SEQRES 8 J 125 ALA VAL TYR TYR CYS ALA THR GLY GLY MET SER SER ALA SEQRES 9 J 125 LEU GLN SER SER LYS TYR TYR PHE ASP PHE TRP GLY GLN SEQRES 10 J 125 GLY ALA LEU VAL THR VAL SER SER SEQRES 1 M 128 ALA LEU THR GLN PRO PRO SER VAL SER GLY SER PRO GLY SEQRES 2 M 128 GLN SER VAL THR ILE SER CYS THR GLY THR SER SER ASP SEQRES 3 M 128 ILE GLY SER TYR ASN TYR VAL SER TRP TYR GLN GLN HIS SEQRES 4 M 128 PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP VAL THR SEQRES 5 M 128 GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SER SEQRES 6 M 128 LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY LEU SEQRES 7 M 128 GLN ALA ASP ASP GLU ALA ASP TYR TYR CYS SER ALA TYR SEQRES 8 M 128 ALA GLY ARG GLN THR PHE TYR ILE PHE GLY GLY GLY THR SEQRES 9 M 128 ARG LEU THR VAL LEU GLY GLN PRO LYS ALA SER PRO THR SEQRES 10 M 128 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 1 G 153 ALA ALA GLY ILE GLY ALA SER SER ASP GLY PHE LEU GLY SEQRES 2 G 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 G 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 G 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU PRO GLN GLN SEQRES 5 G 153 HIS LEU LEU LYS ASP THR HIS TRP GLY ILE LYS GLN LEU SEQRES 6 G 153 GLN ALA ARG VAL LEU ALA VAL GLU HIS TYR LEU ARG ASP SEQRES 7 G 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 G 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 G 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 G 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 G 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 G 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 O 130 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 O 130 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 O 130 TYR THR PHE THR ASP HIS TYR ILE HIS TRP VAL ARG GLN SEQRES 4 O 130 ALA PRO ARG GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 O 130 PRO TYR ASN GLY ASN THR ASN TYR ALA GLN LYS PHE GLN SEQRES 6 O 130 GLY ARG VAL THR LEU THR ARG ASP THR SER THR THR THR SEQRES 7 O 130 VAL TYR MET GLU LEU ILE SER LEU ARG SER GLU ASP THR SEQRES 8 O 130 ALA VAL TYR TYR CYS ALA ARG GLY GLY GLU TYR CYS THR SEQRES 9 O 130 GLY PHE GLY CYS PHE ALA GLY LYS GLY ASP ASN SER LEU SEQRES 10 O 130 ASP VAL TRP GLY ARG GLY VAL LEU VAL SER VAL SER SER SEQRES 1 Q 113 ASP ILE VAL MET ILE GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 Q 113 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 Q 113 GLN SER LEU PHE ASP ILE GLU ASP GLU THR THR TYR LEU SEQRES 4 Q 113 GLU TRP PHE LEU GLN LYS PRO GLY GLN SER PRO GLN PRO SEQRES 5 Q 113 LEU ILE TYR GLU VAL SER ASN ARG ALA SER GLY VAL PRO SEQRES 6 Q 113 ASP ARG PHE SER GLY SER GLY SER ASP THR ALA PHE THR SEQRES 7 Q 113 LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY ILE SEQRES 8 Q 113 TYR TYR CYS MET GLN GLY ILE GLU TYR PRO PHE THR PHE SEQRES 9 Q 113 GLY PRO GLY THR LYS VAL GLU ILE LYS SEQRES 1 F 481 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 F 481 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 F 481 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 F 481 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 F 481 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 F 481 TRP LYS ASN ASN MET VAL GLU GLN MET HIS GLU ASP ILE SEQRES 7 F 481 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 F 481 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN TYR SEQRES 9 F 481 ALA PRO LYS LEU ARG SER MET MET ARG GLY GLU ILE LYS SEQRES 10 F 481 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 F 481 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 F 481 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 F 481 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 F 481 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 F 481 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 F 481 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 F 481 CYS GLN ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 F 481 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 F 481 LEU ALA GLU GLU GLU VAL ILE ILE ARG SER GLU ASN ILE SEQRES 20 F 481 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN LEU ASN THR SEQRES 21 F 481 SER VAL GLN ILE ASN CYS THR ARG PRO SER ASN ASN THR SEQRES 22 F 481 VAL LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 F 481 TYR PHE GLY ASP VAL LEU GLY HIS VAL ARG MET ALA HIS SEQRES 24 F 481 CYS ASN ILE SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 F 481 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 F 481 THR ILE ILE ARG PHE ALA GLN SER SER GLY GLY ASP LEU SEQRES 27 F 481 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 F 481 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 F 481 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 F 481 SER ASN ASP SER LEU ILE LEU PRO CYS TRP ILE LYS GLN SEQRES 31 F 481 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR SEQRES 32 F 481 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 F 481 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 F 481 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 F 481 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 F 481 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 F 481 CYS LYS ARG ARG THR VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 K 125 GLU VAL GLN LEU VAL GLU THR GLY GLY GLY LEU VAL GLN SEQRES 2 K 125 PRO GLY GLY SER LEU LYS LEU SER CYS ARG ALA SER GLY SEQRES 3 K 125 TYR THR PHE SER SER PHE ALA MET SER TRP VAL ARG GLN SEQRES 4 K 125 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER LEU ILE ASN SEQRES 5 K 125 ASP ARG GLY GLY LEU THR PHE TYR VAL ASP SER VAL LYS SEQRES 6 K 125 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 K 125 LEU SER LEU GLN MET HIS SER LEU ARG ASP GLY ASP THR SEQRES 8 K 125 ALA VAL TYR TYR CYS ALA THR GLY GLY MET SER SER ALA SEQRES 9 K 125 LEU GLN SER SER LYS TYR TYR PHE ASP PHE TRP GLY GLN SEQRES 10 K 125 GLY ALA LEU VAL THR VAL SER SER SEQRES 1 N 128 ALA LEU THR GLN PRO PRO SER VAL SER GLY SER PRO GLY SEQRES 2 N 128 GLN SER VAL THR ILE SER CYS THR GLY THR SER SER ASP SEQRES 3 N 128 ILE GLY SER TYR ASN TYR VAL SER TRP TYR GLN GLN HIS SEQRES 4 N 128 PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP VAL THR SEQRES 5 N 128 GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SER SEQRES 6 N 128 LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY LEU SEQRES 7 N 128 GLN ALA ASP ASP GLU ALA ASP TYR TYR CYS SER ALA TYR SEQRES 8 N 128 ALA GLY ARG GLN THR PHE TYR ILE PHE GLY GLY GLY THR SEQRES 9 N 128 ARG LEU THR VAL LEU GLY GLN PRO LYS ALA SER PRO THR SEQRES 10 N 128 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 1 I 153 ALA ALA GLY ILE GLY ALA SER SER ASP GLY PHE LEU GLY SEQRES 2 I 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 I 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 I 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU PRO GLN GLN SEQRES 5 I 153 HIS LEU LEU LYS ASP THR HIS TRP GLY ILE LYS GLN LEU SEQRES 6 I 153 GLN ALA ARG VAL LEU ALA VAL GLU HIS TYR LEU ARG ASP SEQRES 7 I 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 I 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 I 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 I 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 I 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 I 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 P 130 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 P 130 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 P 130 TYR THR PHE THR ASP HIS TYR ILE HIS TRP VAL ARG GLN SEQRES 4 P 130 ALA PRO ARG GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 P 130 PRO TYR ASN GLY ASN THR ASN TYR ALA GLN LYS PHE GLN SEQRES 6 P 130 GLY ARG VAL THR LEU THR ARG ASP THR SER THR THR THR SEQRES 7 P 130 VAL TYR MET GLU LEU ILE SER LEU ARG SER GLU ASP THR SEQRES 8 P 130 ALA VAL TYR TYR CYS ALA ARG GLY GLY GLU TYR CYS THR SEQRES 9 P 130 GLY PHE GLY CYS PHE ALA GLY LYS GLY ASP ASN SER LEU SEQRES 10 P 130 ASP VAL TRP GLY ARG GLY VAL LEU VAL SER VAL SER SER SEQRES 1 R 113 ASP ILE VAL MET ILE GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 R 113 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 R 113 GLN SER LEU PHE ASP ILE GLU ASP GLU THR THR TYR LEU SEQRES 4 R 113 GLU TRP PHE LEU GLN LYS PRO GLY GLN SER PRO GLN PRO SEQRES 5 R 113 LEU ILE TYR GLU VAL SER ASN ARG ALA SER GLY VAL PRO SEQRES 6 R 113 ASP ARG PHE SER GLY SER GLY SER ASP THR ALA PHE THR SEQRES 7 R 113 LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY ILE SEQRES 8 R 113 TYR TYR CYS MET GLN GLY ILE GLU TYR PRO PHE THR PHE SEQRES 9 R 113 GLY PRO GLY THR LYS VAL GLU ILE LYS HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG A 604 14 HET NAG A 605 14 HET NAG A 606 14 HET NAG A 607 14 HET NAG A 608 14 HET NAG A 609 14 HET NAG A 610 14 HET NAG A 611 14 HET NAG A 612 14 HET NAG A 613 14 HET NAG B 701 14 HET NAG E 601 14 HET NAG E 602 14 HET NAG E 603 14 HET NAG E 604 14 HET NAG E 605 14 HET NAG E 606 14 HET NAG E 607 14 HET NAG E 608 14 HET NAG E 609 14 HET NAG E 610 14 HET NAG E 611 14 HET NAG E 612 14 HET NAG E 613 14 HET NAG G 701 14 HET NAG F 601 14 HET NAG F 602 14 HET NAG F 603 14 HET NAG F 604 14 HET NAG F 605 14 HET NAG F 606 14 HET NAG F 607 14 HET NAG F 608 14 HET NAG F 609 14 HET NAG F 610 14 HET NAG F 611 14 HET NAG F 612 14 HET NAG F 613 14 HET NAG I 701 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG X 1 14 HET NAG X 2 14 HET BMA X 3 11 HET NAG Y 1 14 HET NAG Y 2 14 HET NAG Z 1 14 HET NAG Z 2 14 HET NAG a 1 14 HET NAG a 2 14 HET BMA a 3 11 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE FORMUL 19 NAG 60(C8 H15 N O6) FORMUL 63 BMA 3(C6 H12 O6) HELIX 1 AA1 ASN A 98 LYS A 117 1 20 HELIX 2 AA2 LEU A 122 CYS A 126 5 5 HELIX 3 AA3 LYS A 335 GLY A 354 1 20 HELIX 4 AA4 ASP A 368 THR A 373 1 6 HELIX 5 AA5 ASP A 474 TYR A 484 1 11 HELIX 6 AA6 THR C 28 PHE C 32 5 5 HELIX 7 AA7 ASP C 61 LYS C 64 5 4 HELIX 8 AA8 ARG C 83 THR C 87 5 5 HELIX 9 AA9 GLN D 79 GLU D 83 5 5 HELIX 10 AB1 THR B 529 SER B 534 1 6 HELIX 11 AB2 THR B 536 SER B 546 1 11 HELIX 12 AB3 ILE B 573 TRP B 596 1 24 HELIX 13 AB4 ASN B 618 ASP B 624 1 7 HELIX 14 AB5 THR B 627 ILE B 635 1 9 HELIX 15 AB6 TYR B 638 ALA B 662 1 25 HELIX 16 AB7 THR H 28 HIS H 32 5 5 HELIX 17 AB8 GLN H 61 GLN H 64 5 4 HELIX 18 AB9 ARG H 83 THR H 87 5 5 HELIX 19 AC1 GLU L 79 VAL L 83 5 5 HELIX 20 AC2 ASN E 98 LYS E 117 1 20 HELIX 21 AC3 LEU E 122 CYS E 126 5 5 HELIX 22 AC4 LYS E 335 GLY E 354 1 20 HELIX 23 AC5 ASP E 368 THR E 373 1 6 HELIX 24 AC6 ASP E 474 TYR E 484 1 11 HELIX 25 AC7 THR J 28 PHE J 32 5 5 HELIX 26 AC8 ASP J 61 LYS J 64 5 4 HELIX 27 AC9 ARG J 83 THR J 87 5 5 HELIX 28 AD1 GLN M 79 GLU M 83 5 5 HELIX 29 AD2 THR G 529 SER G 534 1 6 HELIX 30 AD3 THR G 536 SER G 546 1 11 HELIX 31 AD4 ILE G 573 TRP G 596 1 24 HELIX 32 AD5 ASN G 618 ASP G 624 1 7 HELIX 33 AD6 THR G 627 ILE G 635 1 9 HELIX 34 AD7 TYR G 638 ALA G 662 1 25 HELIX 35 AD8 THR O 28 HIS O 32 5 5 HELIX 36 AD9 GLN O 61 GLN O 64 5 4 HELIX 37 AE1 ARG O 83 THR O 87 5 5 HELIX 38 AE2 GLU Q 79 VAL Q 83 5 5 HELIX 39 AE3 ASN F 98 LYS F 117 1 20 HELIX 40 AE4 LEU F 122 CYS F 126 5 5 HELIX 41 AE5 LYS F 335 GLY F 354 1 20 HELIX 42 AE6 ASP F 368 THR F 373 1 6 HELIX 43 AE7 ASP F 474 TYR F 484 1 11 HELIX 44 AE8 THR K 28 PHE K 32 5 5 HELIX 45 AE9 ASP K 61 LYS K 64 5 4 HELIX 46 AF1 ARG K 83 THR K 87 5 5 HELIX 47 AF2 GLN N 79 GLU N 83 5 5 HELIX 48 AF3 THR I 529 SER I 534 1 6 HELIX 49 AF4 THR I 536 SER I 546 1 11 HELIX 50 AF5 ILE I 573 TRP I 596 1 24 HELIX 51 AF6 ASN I 618 ASP I 624 1 7 HELIX 52 AF7 THR I 627 ILE I 635 1 9 HELIX 53 AF8 TYR I 638 ALA I 662 1 25 HELIX 54 AF9 THR P 28 HIS P 32 5 5 HELIX 55 AG1 GLN P 61 GLN P 64 5 4 HELIX 56 AG2 ARG P 83 THR P 87 5 5 HELIX 57 AG3 GLU R 79 VAL R 83 5 5 SHEET 1 AA1 3 LEU A 494 THR A 499 0 SHEET 2 AA1 3 TRP A 35 TYR A 40 -1 N TRP A 35 O THR A 499 SHEET 3 AA1 3 ILE B 603 PRO B 609 -1 O VAL B 608 N VAL A 36 SHEET 1 AA2 5 TRP A 45 ASP A 47 0 SHEET 2 AA2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AA2 5 PHE A 223 LYS A 227 -1 N LEU A 226 O LYS A 487 SHEET 4 AA2 5 SER A 243 VAL A 245 -1 O SER A 243 N LYS A 227 SHEET 5 AA2 5 GLU A 83 HIS A 85 -1 N ILE A 84 O THR A 244 SHEET 1 AA3 3 VAL A 75 PRO A 76 0 SHEET 2 AA3 3 PHE A 53 SER A 56 1 N CYS A 54 O VAL A 75 SHEET 3 AA3 3 HIS A 216 CYS A 218 -1 O HIS A 216 N ALA A 55 SHEET 1 AA4 2 GLU A 91 ASN A 94 0 SHEET 2 AA4 2 THR A 236 CYS A 239 -1 O GLY A 237 N PHE A 93 SHEET 1 AA5 5 LYS A 169 TYR A 177 0 SHEET 2 AA5 5 ILE A 154 THR A 162 -1 N CYS A 157 O SER A 174 SHEET 3 AA5 5 LEU A 129 ASN A 133 -1 N GLN A 130 O SER A 158 SHEET 4 AA5 5 LYS A 189 LEU A 193 -1 O TYR A 191 N LEU A 129 SHEET 5 AA5 5 VAL A 181 GLN A 183 -1 N VAL A 182 O ARG A 192 SHEET 1 AA6 3 ALA A 200 GLN A 203 0 SHEET 2 AA6 3 GLN A 432 TYR A 435 1 O TYR A 435 N THR A 202 SHEET 3 AA6 3 ILE A 423 ILE A 424 -1 N ILE A 424 O MET A 434 SHEET 1 AA712 LEU A 259 LEU A 261 0 SHEET 2 AA712 ILE A 271 SER A 274 0 SHEET 3 AA712 ILE A 284 GLY A 312 -1 O GLN A 287 N ILE A 271 SHEET 4 AA712 GLN A 315 LEU A 323A-1 O PHE A 317 N ILE A 307 SHEET 5 AA712 ALA A 329 SER A 334 -1 O ASN A 332 N ASN A 295 SHEET 6 AA712 ILE A 358 PHE A 361 0 SHEET 7 AA712 HIS A 374 CYS A 378 0 SHEET 8 AA712 GLU A 381 CYS A 385 -1 O CYS A 385 N HIS A 374 SHEET 9 AA712 SER A 393 ILE A 396 -1 O SER A 393 N PHE A 361 SHEET 10 AA712 SER A 413 LYS A 421 -1 O TRP A 419 N TYR A 384 SHEET 11 AA712 GLY A 441 ARG A 456 -1 O LEU A 454 N ILE A 284 SHEET 12 AA712 THR A 465 ARG A 469 -1 O ARG A 469 N THR A 455 SHEET 1 AA8 4 GLN C 3 THR C 7 0 SHEET 2 AA8 4 SER C 17 SER C 25 -1 O SER C 21 N THR C 7 SHEET 3 AA8 4 THR C 77 HIS C 82A-1 O LEU C 78 N CYS C 22 SHEET 4 AA8 4 PHE C 67 ASP C 72 -1 N ASP C 72 O THR C 77 SHEET 1 AA9 6 MET C 34 GLN C 39 0 SHEET 2 AA9 6 LEU C 45 ILE C 51 -1 O ILE C 51 N MET C 34 SHEET 3 AA9 6 THR C 57 TYR C 59 -1 O PHE C 58 N LEU C 50 SHEET 4 AA9 6 ALA C 88 GLY C 95 -1 O TYR C 91 N VAL C 37 SHEET 5 AA9 6 PHE C 100H TRP C 103 -1 O ASP C 101 N THR C 94 SHEET 6 AA9 6 ALA C 107 VAL C 109 -1 O ALA C 107 N TYR C 90 SHEET 1 AB1 3 VAL D 19 THR D 24 0 SHEET 2 AB1 3 THR D 70 ILE D 75 -1 O LEU D 73 N ILE D 21 SHEET 3 AB1 3 PHE D 62 SER D 67 -1 N SER D 63 O THR D 74 SHEET 1 AB2 5 VAL D 33 GLN D 38 0 SHEET 2 AB2 5 LYS D 45 ILE D 48 -1 O MET D 47 N TRP D 35 SHEET 3 AB2 5 ASP D 85 ALA D 92 -1 O ASP D 85 N GLN D 38 SHEET 4 AB2 5 THR D 95A PHE D 98 -1 O ILE D 97 N ALA D 90 SHEET 5 AB2 5 THR D 102 ARG D 103 -1 O THR D 102 N TYR D 86 SHEET 1 AB3 4 GLN H 3 VAL H 5 0 SHEET 2 AB3 4 VAL H 18 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AB3 4 THR H 77 LEU H 82 -1 O MET H 80 N VAL H 20 SHEET 4 AB3 4 VAL H 67 ASP H 72 -1 N THR H 68 O GLU H 81 SHEET 1 AB4 7 ALA H 9 LYS H 12 0 SHEET 2 AB4 7 ILE H 34 GLN H 39 0 SHEET 3 AB4 7 LEU H 45 ILE H 51 -1 O GLU H 46 N ARG H 38 SHEET 4 AB4 7 THR H 57 TYR H 59 -1 O ASN H 58 N TRP H 50 SHEET 5 AB4 7 ALA H 88 GLY H 95 -1 O TYR H 91 N VAL H 37 SHEET 6 AB4 7 LEU H 100M TRP H 103 -1 O VAL H 102 N ARG H 94 SHEET 7 AB4 7 VAL H 107 VAL H 111 -1 O VAL H 107 N TYR H 90 SHEET 1 AB5 4 ILE L 5 GLN L 6 0 SHEET 2 AB5 4 ALA L 19 SER L 25 -1 O ARG L 24 N GLN L 6 SHEET 3 AB5 4 ALA L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AB5 4 PHE L 62 SER L 67 -1 N SER L 65 O THR L 72 SHEET 1 AB6 2 PHE L 27C ASP L 27D 0 SHEET 2 AB6 2 THR L 30 THR L 31 -1 O THR L 30 N ASP L 27D SHEET 1 AB7 5 ASN L 53 ARG L 54 0 SHEET 2 AB7 5 GLN L 45 GLU L 50 -1 N TYR L 49 O ASN L 53 SHEET 3 AB7 5 TRP L 35 GLN L 38 -1 N TRP L 35 O LEU L 47 SHEET 4 AB7 5 GLY L 84 CYS L 88 -1 O ILE L 85 N GLN L 38 SHEET 5 AB7 5 THR L 102 VAL L 104 -1 O THR L 102 N TYR L 86 SHEET 1 AB8 3 LEU E 494 THR E 499 0 SHEET 2 AB8 3 TRP E 35 TYR E 40 -1 N TRP E 35 O THR E 499 SHEET 3 AB8 3 ILE G 603 PRO G 609 -1 O VAL G 608 N VAL E 36 SHEET 1 AB9 5 TRP E 45 ASP E 47 0 SHEET 2 AB9 5 TYR E 486 ILE E 491 -1 O LYS E 490 N LYS E 46 SHEET 3 AB9 5 PHE E 223 LYS E 227 -1 N LEU E 226 O LYS E 487 SHEET 4 AB9 5 SER E 243 VAL E 245 -1 O SER E 243 N LYS E 227 SHEET 5 AB9 5 GLU E 83 HIS E 85 -1 N ILE E 84 O THR E 244 SHEET 1 AC1 3 VAL E 75 PRO E 76 0 SHEET 2 AC1 3 PHE E 53 SER E 56 1 N CYS E 54 O VAL E 75 SHEET 3 AC1 3 HIS E 216 CYS E 218 -1 O HIS E 216 N ALA E 55 SHEET 1 AC2 2 GLU E 91 ASN E 94 0 SHEET 2 AC2 2 THR E 236 CYS E 239 -1 O GLY E 237 N PHE E 93 SHEET 1 AC3 5 LYS E 169 TYR E 177 0 SHEET 2 AC3 5 ILE E 154 THR E 162 -1 N CYS E 157 O SER E 174 SHEET 3 AC3 5 LEU E 129 ASN E 133 -1 N GLN E 130 O SER E 158 SHEET 4 AC3 5 LYS E 189 LEU E 193 -1 O TYR E 191 N LEU E 129 SHEET 5 AC3 5 VAL E 181 GLN E 183 -1 N VAL E 182 O ARG E 192 SHEET 1 AC4 3 ALA E 200 GLN E 203 0 SHEET 2 AC4 3 GLN E 432 TYR E 435 1 O TYR E 435 N THR E 202 SHEET 3 AC4 3 ILE E 423 ILE E 424 -1 N ILE E 424 O MET E 434 SHEET 1 AC512 LEU E 259 LEU E 261 0 SHEET 2 AC512 ILE E 271 SER E 274 0 SHEET 3 AC512 ILE E 284 GLY E 312 -1 O GLN E 287 N ILE E 271 SHEET 4 AC512 GLN E 315 LEU E 323A-1 O PHE E 317 N ILE E 307 SHEET 5 AC512 ALA E 329 SER E 334 -1 O ASN E 332 N ASN E 295 SHEET 6 AC512 ILE E 358 PHE E 361 0 SHEET 7 AC512 HIS E 374 CYS E 378 0 SHEET 8 AC512 GLU E 381 CYS E 385 -1 O CYS E 385 N HIS E 374 SHEET 9 AC512 SER E 393 ILE E 396 -1 O SER E 393 N PHE E 361 SHEET 10 AC512 SER E 413 LYS E 421 -1 O TRP E 419 N TYR E 384 SHEET 11 AC512 GLY E 441 ARG E 456 -1 O LEU E 454 N ILE E 284 SHEET 12 AC512 THR E 465 ARG E 469 -1 O ARG E 469 N THR E 455 SHEET 1 AC6 4 GLN J 3 THR J 7 0 SHEET 2 AC6 4 SER J 17 SER J 25 -1 O ARG J 23 N VAL J 5 SHEET 3 AC6 4 THR J 77 HIS J 82A-1 O LEU J 78 N CYS J 22 SHEET 4 AC6 4 PHE J 67 ASP J 72 -1 N ASP J 72 O THR J 77 SHEET 1 AC7 6 MET J 34 GLN J 39 0 SHEET 2 AC7 6 LEU J 45 ILE J 51 -1 O ILE J 51 N MET J 34 SHEET 3 AC7 6 THR J 57 TYR J 59 -1 O PHE J 58 N LEU J 50 SHEET 4 AC7 6 ALA J 88 GLY J 95 -1 O TYR J 91 N VAL J 37 SHEET 5 AC7 6 PHE J 100H TRP J 103 -1 O ASP J 101 N THR J 94 SHEET 6 AC7 6 ALA J 107 VAL J 109 -1 O ALA J 107 N TYR J 90 SHEET 1 AC8 3 VAL M 19 THR M 24 0 SHEET 2 AC8 3 THR M 70 ILE M 75 -1 O LEU M 73 N ILE M 21 SHEET 3 AC8 3 PHE M 62 SER M 67 -1 N SER M 63 O THR M 74 SHEET 1 AC9 5 VAL M 33 GLN M 38 0 SHEET 2 AC9 5 LYS M 45 ILE M 48 -1 O MET M 47 N TRP M 35 SHEET 3 AC9 5 ASP M 85 ALA M 92 -1 O ASP M 85 N GLN M 38 SHEET 4 AC9 5 THR M 95A PHE M 98 -1 O ILE M 97 N ALA M 90 SHEET 5 AC9 5 THR M 102 ARG M 103 -1 O THR M 102 N TYR M 86 SHEET 1 AD1 4 GLN O 3 VAL O 5 0 SHEET 2 AD1 4 VAL O 18 SER O 25 -1 O SER O 25 N GLN O 3 SHEET 3 AD1 4 THR O 77 LEU O 82 -1 O MET O 80 N VAL O 20 SHEET 4 AD1 4 VAL O 67 ASP O 72 -1 N THR O 68 O GLU O 81 SHEET 1 AD2 7 ALA O 9 LYS O 12 0 SHEET 2 AD2 7 ILE O 34 GLN O 39 0 SHEET 3 AD2 7 LEU O 45 ILE O 51 -1 O GLU O 46 N ARG O 38 SHEET 4 AD2 7 THR O 57 TYR O 59 -1 O ASN O 58 N TRP O 50 SHEET 5 AD2 7 ALA O 88 GLY O 95 -1 O TYR O 91 N VAL O 37 SHEET 6 AD2 7 LEU O 100M TRP O 103 -1 O VAL O 102 N ARG O 94 SHEET 7 AD2 7 VAL O 107 VAL O 111 -1 O VAL O 107 N TYR O 90 SHEET 1 AD3 4 ILE Q 5 GLN Q 6 0 SHEET 2 AD3 4 ALA Q 19 SER Q 25 -1 O ARG Q 24 N GLN Q 6 SHEET 3 AD3 4 ALA Q 70 ILE Q 75 -1 O LEU Q 73 N ILE Q 21 SHEET 4 AD3 4 PHE Q 62 SER Q 67 -1 N SER Q 65 O THR Q 72 SHEET 1 AD4 2 PHE Q 27C ASP Q 27D 0 SHEET 2 AD4 2 THR Q 30 THR Q 31 -1 O THR Q 30 N ASP Q 27D SHEET 1 AD5 5 ASN Q 53 ARG Q 54 0 SHEET 2 AD5 5 GLN Q 45 GLU Q 50 -1 N TYR Q 49 O ASN Q 53 SHEET 3 AD5 5 TRP Q 35 GLN Q 38 -1 N TRP Q 35 O LEU Q 47 SHEET 4 AD5 5 GLY Q 84 CYS Q 88 -1 O ILE Q 85 N GLN Q 38 SHEET 5 AD5 5 THR Q 102 VAL Q 104 -1 O THR Q 102 N TYR Q 86 SHEET 1 AD6 3 LEU F 494 THR F 499 0 SHEET 2 AD6 3 TRP F 35 TYR F 40 -1 N TRP F 35 O THR F 499 SHEET 3 AD6 3 ILE I 603 PRO I 609 -1 O VAL I 608 N VAL F 36 SHEET 1 AD7 5 TRP F 45 ASP F 47 0 SHEET 2 AD7 5 TYR F 486 ILE F 491 -1 O LYS F 490 N LYS F 46 SHEET 3 AD7 5 PHE F 223 LYS F 227 -1 N LEU F 226 O LYS F 487 SHEET 4 AD7 5 SER F 243 VAL F 245 -1 O SER F 243 N LYS F 227 SHEET 5 AD7 5 GLU F 83 HIS F 85 -1 N ILE F 84 O THR F 244 SHEET 1 AD8 3 VAL F 75 PRO F 76 0 SHEET 2 AD8 3 PHE F 53 SER F 56 1 N CYS F 54 O VAL F 75 SHEET 3 AD8 3 HIS F 216 CYS F 218 -1 O HIS F 216 N ALA F 55 SHEET 1 AD9 2 GLU F 91 ASN F 94 0 SHEET 2 AD9 2 THR F 236 CYS F 239 -1 O GLY F 237 N PHE F 93 SHEET 1 AE1 5 LYS F 169 TYR F 177 0 SHEET 2 AE1 5 ILE F 154 THR F 162 -1 N CYS F 157 O SER F 174 SHEET 3 AE1 5 LEU F 129 ASN F 133 -1 N GLN F 130 O SER F 158 SHEET 4 AE1 5 LYS F 189 LEU F 193 -1 O TYR F 191 N LEU F 129 SHEET 5 AE1 5 VAL F 181 GLN F 183 -1 N VAL F 182 O ARG F 192 SHEET 1 AE2 3 ALA F 200 GLN F 203 0 SHEET 2 AE2 3 GLN F 432 TYR F 435 1 O TYR F 435 N THR F 202 SHEET 3 AE2 3 ILE F 423 ILE F 424 -1 N ILE F 424 O MET F 434 SHEET 1 AE312 LEU F 259 LEU F 261 0 SHEET 2 AE312 ILE F 271 SER F 274 0 SHEET 3 AE312 ILE F 284 GLY F 312 -1 O GLN F 287 N ILE F 271 SHEET 4 AE312 GLN F 315 LEU F 323A-1 O PHE F 317 N ILE F 307 SHEET 5 AE312 ALA F 329 SER F 334 -1 O ASN F 332 N ASN F 295 SHEET 6 AE312 ILE F 358 PHE F 361 0 SHEET 7 AE312 HIS F 374 CYS F 378 0 SHEET 8 AE312 GLU F 381 CYS F 385 -1 O CYS F 385 N HIS F 374 SHEET 9 AE312 SER F 393 ILE F 396 -1 O SER F 393 N PHE F 361 SHEET 10 AE312 SER F 413 LYS F 421 -1 O TRP F 419 N TYR F 384 SHEET 11 AE312 GLY F 441 ARG F 456 -1 O LEU F 454 N ILE F 284 SHEET 12 AE312 THR F 465 ARG F 469 -1 O ARG F 469 N THR F 455 SHEET 1 AE4 4 GLN K 3 THR K 7 0 SHEET 2 AE4 4 SER K 17 SER K 25 -1 O ARG K 23 N VAL K 5 SHEET 3 AE4 4 THR K 77 HIS K 82A-1 O LEU K 78 N CYS K 22 SHEET 4 AE4 4 PHE K 67 ASP K 72 -1 N ASP K 72 O THR K 77 SHEET 1 AE5 6 MET K 34 GLN K 39 0 SHEET 2 AE5 6 LEU K 45 ILE K 51 -1 O ILE K 51 N MET K 34 SHEET 3 AE5 6 THR K 57 TYR K 59 -1 O PHE K 58 N LEU K 50 SHEET 4 AE5 6 ALA K 88 GLY K 95 -1 O TYR K 91 N VAL K 37 SHEET 5 AE5 6 PHE K 100H TRP K 103 -1 O ASP K 101 N THR K 94 SHEET 6 AE5 6 ALA K 107 VAL K 109 -1 O ALA K 107 N TYR K 90 SHEET 1 AE6 3 VAL N 19 THR N 24 0 SHEET 2 AE6 3 THR N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 3 AE6 3 PHE N 62 SER N 67 -1 N SER N 63 O THR N 74 SHEET 1 AE7 5 VAL N 33 GLN N 38 0 SHEET 2 AE7 5 LYS N 45 ILE N 48 -1 O MET N 47 N TRP N 35 SHEET 3 AE7 5 ASP N 85 ALA N 92 -1 O ASP N 85 N GLN N 38 SHEET 4 AE7 5 THR N 95A PHE N 98 -1 O ILE N 97 N ALA N 90 SHEET 5 AE7 5 THR N 102 ARG N 103 -1 O THR N 102 N TYR N 86 SHEET 1 AE8 4 GLN P 3 VAL P 5 0 SHEET 2 AE8 4 VAL P 18 SER P 25 -1 O SER P 25 N GLN P 3 SHEET 3 AE8 4 THR P 77 LEU P 82 -1 O MET P 80 N VAL P 20 SHEET 4 AE8 4 VAL P 67 ASP P 72 -1 N THR P 68 O GLU P 81 SHEET 1 AE9 7 ALA P 9 LYS P 12 0 SHEET 2 AE9 7 ILE P 34 GLN P 39 0 SHEET 3 AE9 7 LEU P 45 ILE P 51 -1 O GLU P 46 N ARG P 38 SHEET 4 AE9 7 THR P 57 TYR P 59 -1 O ASN P 58 N TRP P 50 SHEET 5 AE9 7 ALA P 88 GLY P 95 -1 O TYR P 91 N VAL P 37 SHEET 6 AE9 7 LEU P 100M TRP P 103 -1 O VAL P 102 N ARG P 94 SHEET 7 AE9 7 VAL P 107 VAL P 111 -1 O VAL P 107 N TYR P 90 SHEET 1 AF1 4 ILE R 5 GLN R 6 0 SHEET 2 AF1 4 ALA R 19 SER R 25 -1 O ARG R 24 N GLN R 6 SHEET 3 AF1 4 ALA R 70 ILE R 75 -1 O LEU R 73 N ILE R 21 SHEET 4 AF1 4 PHE R 62 SER R 67 -1 N SER R 65 O THR R 72 SHEET 1 AF2 2 PHE R 27C ASP R 27D 0 SHEET 2 AF2 2 THR R 30 THR R 31 -1 O THR R 30 N ASP R 27D SHEET 1 AF3 5 ASN R 53 ARG R 54 0 SHEET 2 AF3 5 GLN R 45 GLU R 50 -1 N TYR R 49 O ASN R 53 SHEET 3 AF3 5 TRP R 35 GLN R 38 -1 N TRP R 35 O LEU R 47 SHEET 4 AF3 5 GLY R 84 CYS R 88 -1 O ILE R 85 N GLN R 38 SHEET 5 AF3 5 THR R 102 VAL R 104 -1 O THR R 102 N TYR R 86 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.04 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.04 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.04 SSBOND 4 CYS A 131 CYS A 157 1555 1555 2.03 SSBOND 5 CYS A 218 CYS A 247 1555 1555 2.04 SSBOND 6 CYS A 228 CYS A 239 1555 1555 2.04 SSBOND 7 CYS A 296 CYS A 331 1555 1555 2.03 SSBOND 8 CYS A 378 CYS A 445 1555 1555 2.04 SSBOND 9 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 10 CYS A 501 CYS B 605 1555 1555 2.02 SSBOND 11 CYS C 22 CYS C 92 1555 1555 2.03 SSBOND 12 CYS D 23 CYS D 88 1555 1555 2.04 SSBOND 13 CYS B 598 CYS B 604 1555 1555 2.02 SSBOND 14 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 15 CYS H 99 CYS H 100D 1555 1555 2.03 SSBOND 16 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 17 CYS E 54 CYS E 74 1555 1555 2.04 SSBOND 18 CYS E 119 CYS E 205 1555 1555 2.04 SSBOND 19 CYS E 126 CYS E 196 1555 1555 2.04 SSBOND 20 CYS E 131 CYS E 157 1555 1555 2.03 SSBOND 21 CYS E 218 CYS E 247 1555 1555 2.03 SSBOND 22 CYS E 228 CYS E 239 1555 1555 2.04 SSBOND 23 CYS E 296 CYS E 331 1555 1555 2.03 SSBOND 24 CYS E 378 CYS E 445 1555 1555 2.04 SSBOND 25 CYS E 385 CYS E 418 1555 1555 2.03 SSBOND 26 CYS E 501 CYS G 605 1555 1555 2.02 SSBOND 27 CYS J 22 CYS J 92 1555 1555 2.03 SSBOND 28 CYS M 23 CYS M 88 1555 1555 2.04 SSBOND 29 CYS G 598 CYS G 604 1555 1555 2.02 SSBOND 30 CYS O 22 CYS O 92 1555 1555 2.03 SSBOND 31 CYS O 99 CYS O 100D 1555 1555 2.04 SSBOND 32 CYS Q 23 CYS Q 88 1555 1555 2.04 SSBOND 33 CYS F 54 CYS F 74 1555 1555 2.04 SSBOND 34 CYS F 119 CYS F 205 1555 1555 2.03 SSBOND 35 CYS F 126 CYS F 196 1555 1555 2.04 SSBOND 36 CYS F 131 CYS F 157 1555 1555 2.03 SSBOND 37 CYS F 218 CYS F 247 1555 1555 2.04 SSBOND 38 CYS F 228 CYS F 239 1555 1555 2.04 SSBOND 39 CYS F 296 CYS F 331 1555 1555 2.03 SSBOND 40 CYS F 378 CYS F 445 1555 1555 2.04 SSBOND 41 CYS F 385 CYS F 418 1555 1555 2.03 SSBOND 42 CYS F 501 CYS I 605 1555 1555 2.02 SSBOND 43 CYS K 22 CYS K 92 1555 1555 2.03 SSBOND 44 CYS N 23 CYS N 88 1555 1555 2.04 SSBOND 45 CYS I 598 CYS I 604 1555 1555 2.02 SSBOND 46 CYS P 22 CYS P 92 1555 1555 2.03 SSBOND 47 CYS P 99 CYS P 100D 1555 1555 2.03 SSBOND 48 CYS R 23 CYS R 88 1555 1555 2.04 LINK ND2 ASN A 88 C1 NAG A 602 1555 1555 1.44 LINK ND2 ASN A 156 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN A 160 C1 NAG A 603 1555 1555 1.44 LINK ND2 ASN A 197 C1 NAG A 604 1555 1555 1.43 LINK ND2 ASN A 234 C1 NAG A 605 1555 1555 1.44 LINK ND2 ASN A 241 C1 NAG A 612 1555 1555 1.44 LINK ND2 ASN A 262 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN A 276 C1 NAG A 606 1555 1555 1.44 LINK ND2 ASN A 289 C1 NAG A 611 1555 1555 1.44 LINK ND2 ASN A 295 C1 NAG A 607 1555 1555 1.44 LINK ND2 ASN A 301 C1 NAG A 601 1555 1555 1.44 LINK ND2 ASN A 332 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN A 339 C1 NAG A 608 1555 1555 1.45 LINK ND2 ASN A 355 C1 NAG A 613 1555 1555 1.44 LINK ND2 ASN A 386 C1 NAG A 609 1555 1555 1.45 LINK ND2 ASN A 448 C1 NAG A 610 1555 1555 1.44 LINK ND2 ASN B 611 C1 NAG B 701 1555 1555 1.45 LINK ND2 ASN E 88 C1 NAG E 602 1555 1555 1.44 LINK ND2 ASN E 156 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN E 160 C1 NAG E 603 1555 1555 1.44 LINK ND2 ASN E 197 C1 NAG E 604 1555 1555 1.43 LINK ND2 ASN E 234 C1 NAG E 605 1555 1555 1.44 LINK ND2 ASN E 241 C1 NAG E 612 1555 1555 1.44 LINK ND2 ASN E 262 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN E 276 C1 NAG E 606 1555 1555 1.44 LINK ND2 ASN E 289 C1 NAG E 611 1555 1555 1.44 LINK ND2 ASN E 295 C1 NAG E 607 1555 1555 1.44 LINK ND2 ASN E 301 C1 NAG E 601 1555 1555 1.44 LINK ND2 ASN E 332 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN E 339 C1 NAG E 608 1555 1555 1.45 LINK ND2 ASN E 355 C1 NAG E 613 1555 1555 1.44 LINK ND2 ASN E 386 C1 NAG E 609 1555 1555 1.45 LINK ND2 ASN E 448 C1 NAG E 610 1555 1555 1.44 LINK ND2 ASN G 611 C1 NAG G 701 1555 1555 1.45 LINK ND2 ASN F 88 C1 NAG F 602 1555 1555 1.44 LINK ND2 ASN F 156 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN F 160 C1 NAG F 603 1555 1555 1.44 LINK ND2 ASN F 197 C1 NAG F 604 1555 1555 1.43 LINK ND2 ASN F 234 C1 NAG F 605 1555 1555 1.44 LINK ND2 ASN F 241 C1 NAG F 612 1555 1555 1.44 LINK ND2 ASN F 262 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN F 276 C1 NAG F 606 1555 1555 1.44 LINK ND2 ASN F 289 C1 NAG F 611 1555 1555 1.44 LINK ND2 ASN F 295 C1 NAG F 607 1555 1555 1.44 LINK ND2 ASN F 301 C1 NAG F 601 1555 1555 1.44 LINK ND2 ASN F 332 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN F 339 C1 NAG F 608 1555 1555 1.45 LINK ND2 ASN F 355 C1 NAG F 613 1555 1555 1.44 LINK ND2 ASN F 386 C1 NAG F 609 1555 1555 1.45 LINK ND2 ASN F 448 C1 NAG F 610 1555 1555 1.44 LINK ND2 ASN I 611 C1 NAG I 701 1555 1555 1.45 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.45 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG X 2 C1 BMA X 3 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.44 LINK O4 NAG a 2 C1 BMA a 3 1555 1555 1.45 CISPEP 1 TYR L 94 PRO L 95 0 -4.61 CISPEP 2 TYR Q 94 PRO Q 95 0 -4.61 CISPEP 3 TYR R 94 PRO R 95 0 -4.60 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000