HEADER ANTIVIRAL PROTEIN 22-AUG-23 8TX3 TITLE FAB 3864-6 IN COMPLEX WITH INFLUENZA HA H3-VIC11 COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: A, C, G; COMPND 4 FRAGMENT: RESIDUES 1-345; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: HEMAGGLUTININ; COMPND 8 CHAIN: B, D, I; COMPND 9 FRAGMENT: RESIDUES 346-521; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: FAB 3864-6 HEAVY CHAIN; COMPND 13 CHAIN: H, E, F; COMPND 14 ENGINEERED: YES; COMPND 15 MOL_ID: 4; COMPND 16 MOLECULE: FAB 3864-6 LIGHT CHAIN; COMPND 17 CHAIN: L, J, K; COMPND 18 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS (A/VICTORIA/361/2011(H3N2)); SOURCE 3 ORGANISM_TAXID: 1268360; SOURCE 4 STRAIN: A/VICTORIA/361/2011(H3N2); SOURCE 5 GENE: HA; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS (A/VICTORIA/361/2011(H3N2)); SOURCE 11 ORGANISM_TAXID: 1268360; SOURCE 12 GENE: HA; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 MOL_ID: 3; SOURCE 17 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 18 ORGANISM_COMMON: HUMAN; SOURCE 19 ORGANISM_TAXID: 9606; SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 21 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 23 MOL_ID: 4; SOURCE 24 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 25 ORGANISM_COMMON: HUMAN; SOURCE 26 ORGANISM_TAXID: 9606; SOURCE 27 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 28 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 29 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS ANTIBODY, INFLUENZA, ANTIVIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR N.C.MORANO,L.SHAPIRO REVDAT 1 11-SEP-24 8TX3 0 JRNL AUTH N.C.MORANO,L.SHAPIRO JRNL TITL FAB 3864-6 IN COMPLEX WITH INFLUENZA HA H3-VIC11 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.99 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX, LEGINON REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.990 REMARK 3 NUMBER OF PARTICLES : 590963 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8TX3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 23-AUG-23. REMARK 100 THE DEPOSITION ID IS D_1000276679. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5806.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, G, I, H, L, E, J, REMARK 350 AND CHAINS: F, K, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -15 REMARK 465 LYS A -14 REMARK 465 THR A -13 REMARK 465 ILE A -12 REMARK 465 ILE A -11 REMARK 465 ALA A -10 REMARK 465 LEU A -9 REMARK 465 SER A -8 REMARK 465 HIS A -7 REMARK 465 ILE A -6 REMARK 465 LEU A -5 REMARK 465 CYS A -4 REMARK 465 LEU A -3 REMARK 465 VAL A -2 REMARK 465 PHE A -1 REMARK 465 ALA A 0 REMARK 465 LYS A 326 REMARK 465 GLN A 327 REMARK 465 THR A 328 REMARK 465 ARG A 329 REMARK 465 ARG A 330 REMARK 465 ARG A 331 REMARK 465 ARG A 332 REMARK 465 ARG A 333 REMARK 465 ARG A 334 REMARK 465 LYS B 174 REMARK 465 GLY B 175 REMARK 465 VAL B 176 REMARK 465 SER B 177 REMARK 465 GLY B 178 REMARK 465 ARG B 179 REMARK 465 LEU B 180 REMARK 465 VAL B 181 REMARK 465 PRO B 182 REMARK 465 ARG B 183 REMARK 465 GLY B 184 REMARK 465 SER B 185 REMARK 465 PRO B 186 REMARK 465 GLY B 187 REMARK 465 SER B 188 REMARK 465 GLY B 189 REMARK 465 TYR B 190 REMARK 465 ILE B 191 REMARK 465 PRO B 192 REMARK 465 GLU B 193 REMARK 465 ALA B 194 REMARK 465 PRO B 195 REMARK 465 ARG B 196 REMARK 465 ASP B 197 REMARK 465 GLY B 198 REMARK 465 GLN B 199 REMARK 465 ALA B 200 REMARK 465 TYR B 201 REMARK 465 VAL B 202 REMARK 465 ARG B 203 REMARK 465 LYS B 204 REMARK 465 ASP B 205 REMARK 465 GLY B 206 REMARK 465 GLU B 207 REMARK 465 TRP B 208 REMARK 465 VAL B 209 REMARK 465 LEU B 210 REMARK 465 LEU B 211 REMARK 465 SER B 212 REMARK 465 THR B 213 REMARK 465 PHE B 214 REMARK 465 LEU B 215 REMARK 465 GLY B 216 REMARK 465 HIS B 217 REMARK 465 HIS B 218 REMARK 465 HIS B 219 REMARK 465 HIS B 220 REMARK 465 HIS B 221 REMARK 465 HIS B 222 REMARK 465 MET C -15 REMARK 465 LYS C -14 REMARK 465 THR C -13 REMARK 465 ILE C -12 REMARK 465 ILE C -11 REMARK 465 ALA C -10 REMARK 465 LEU C -9 REMARK 465 SER C -8 REMARK 465 HIS C -7 REMARK 465 ILE C -6 REMARK 465 LEU C -5 REMARK 465 CYS C -4 REMARK 465 LEU C -3 REMARK 465 VAL C -2 REMARK 465 PHE C -1 REMARK 465 ALA C 0 REMARK 465 LYS C 326 REMARK 465 GLN C 327 REMARK 465 THR C 328 REMARK 465 ARG C 329 REMARK 465 ARG C 330 REMARK 465 ARG C 331 REMARK 465 ARG C 332 REMARK 465 ARG C 333 REMARK 465 ARG C 334 REMARK 465 LYS D 174 REMARK 465 GLY D 175 REMARK 465 VAL D 176 REMARK 465 SER D 177 REMARK 465 GLY D 178 REMARK 465 ARG D 179 REMARK 465 LEU D 180 REMARK 465 VAL D 181 REMARK 465 PRO D 182 REMARK 465 ARG D 183 REMARK 465 GLY D 184 REMARK 465 SER D 185 REMARK 465 PRO D 186 REMARK 465 GLY D 187 REMARK 465 SER D 188 REMARK 465 GLY D 189 REMARK 465 TYR D 190 REMARK 465 ILE D 191 REMARK 465 PRO D 192 REMARK 465 GLU D 193 REMARK 465 ALA D 194 REMARK 465 PRO D 195 REMARK 465 ARG D 196 REMARK 465 ASP D 197 REMARK 465 GLY D 198 REMARK 465 GLN D 199 REMARK 465 ALA D 200 REMARK 465 TYR D 201 REMARK 465 VAL D 202 REMARK 465 ARG D 203 REMARK 465 LYS D 204 REMARK 465 ASP D 205 REMARK 465 GLY D 206 REMARK 465 GLU D 207 REMARK 465 TRP D 208 REMARK 465 VAL D 209 REMARK 465 LEU D 210 REMARK 465 LEU D 211 REMARK 465 SER D 212 REMARK 465 THR D 213 REMARK 465 PHE D 214 REMARK 465 LEU D 215 REMARK 465 GLY D 216 REMARK 465 HIS D 217 REMARK 465 HIS D 218 REMARK 465 HIS D 219 REMARK 465 HIS D 220 REMARK 465 HIS D 221 REMARK 465 HIS D 222 REMARK 465 MET G -15 REMARK 465 LYS G -14 REMARK 465 THR G -13 REMARK 465 ILE G -12 REMARK 465 ILE G -11 REMARK 465 ALA G -10 REMARK 465 LEU G -9 REMARK 465 SER G -8 REMARK 465 HIS G -7 REMARK 465 ILE G -6 REMARK 465 LEU G -5 REMARK 465 CYS G -4 REMARK 465 LEU G -3 REMARK 465 VAL G -2 REMARK 465 PHE G -1 REMARK 465 ALA G 0 REMARK 465 LYS G 326 REMARK 465 GLN G 327 REMARK 465 THR G 328 REMARK 465 ARG G 329 REMARK 465 ARG G 330 REMARK 465 ARG G 331 REMARK 465 ARG G 332 REMARK 465 ARG G 333 REMARK 465 ARG G 334 REMARK 465 LYS I 174 REMARK 465 GLY I 175 REMARK 465 VAL I 176 REMARK 465 SER I 177 REMARK 465 GLY I 178 REMARK 465 ARG I 179 REMARK 465 LEU I 180 REMARK 465 VAL I 181 REMARK 465 PRO I 182 REMARK 465 ARG I 183 REMARK 465 GLY I 184 REMARK 465 SER I 185 REMARK 465 PRO I 186 REMARK 465 GLY I 187 REMARK 465 SER I 188 REMARK 465 GLY I 189 REMARK 465 TYR I 190 REMARK 465 ILE I 191 REMARK 465 PRO I 192 REMARK 465 GLU I 193 REMARK 465 ALA I 194 REMARK 465 PRO I 195 REMARK 465 ARG I 196 REMARK 465 ASP I 197 REMARK 465 GLY I 198 REMARK 465 GLN I 199 REMARK 465 ALA I 200 REMARK 465 TYR I 201 REMARK 465 VAL I 202 REMARK 465 ARG I 203 REMARK 465 LYS I 204 REMARK 465 ASP I 205 REMARK 465 GLY I 206 REMARK 465 GLU I 207 REMARK 465 TRP I 208 REMARK 465 VAL I 209 REMARK 465 LEU I 210 REMARK 465 LEU I 211 REMARK 465 SER I 212 REMARK 465 THR I 213 REMARK 465 PHE I 214 REMARK 465 LEU I 215 REMARK 465 GLY I 216 REMARK 465 HIS I 217 REMARK 465 HIS I 218 REMARK 465 HIS I 219 REMARK 465 HIS I 220 REMARK 465 HIS I 221 REMARK 465 HIS I 222 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 THR H 117 REMARK 465 PRO H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 TYR H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 GLY H 127 REMARK 465 SER H 128 REMARK 465 ALA H 129 REMARK 465 ALA H 130 REMARK 465 GLN H 131 REMARK 465 THR H 132 REMARK 465 ASN H 133 REMARK 465 SER H 134 REMARK 465 MET H 135 REMARK 465 VAL H 136 REMARK 465 THR H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 GLY H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 THR H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 SER H 158 REMARK 465 LEU H 159 REMARK 465 SER H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 ASP H 173 REMARK 465 LEU H 174 REMARK 465 TYR H 175 REMARK 465 THR H 176 REMARK 465 LEU H 177 REMARK 465 SER H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 THR H 182 REMARK 465 VAL H 183 REMARK 465 PRO H 184 REMARK 465 SER H 185 REMARK 465 SER H 186 REMARK 465 THR H 187 REMARK 465 TRP H 188 REMARK 465 PRO H 189 REMARK 465 SER H 190 REMARK 465 GLU H 191 REMARK 465 THR H 192 REMARK 465 VAL H 193 REMARK 465 THR H 194 REMARK 465 CYS H 195 REMARK 465 ASN H 196 REMARK 465 VAL H 197 REMARK 465 ALA H 198 REMARK 465 HIS H 199 REMARK 465 PRO H 200 REMARK 465 ALA H 201 REMARK 465 SER H 202 REMARK 465 SER H 203 REMARK 465 THR H 204 REMARK 465 LYS H 205 REMARK 465 VAL H 206 REMARK 465 ASP H 207 REMARK 465 LYS H 208 REMARK 465 LYS H 209 REMARK 465 ILE H 210 REMARK 465 VAL H 211 REMARK 465 PRO H 212 REMARK 465 ARG H 213 REMARK 465 ASP H 214 REMARK 465 CYS H 215 REMARK 465 ASP H 216 REMARK 465 LYS H 217 REMARK 465 GLY H 218 REMARK 465 LEU H 219 REMARK 465 GLU H 220 REMARK 465 VAL H 221 REMARK 465 LEU H 222 REMARK 465 PHE H 223 REMARK 465 GLN H 224 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 ASP L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 THR L 114 REMARK 465 VAL L 115 REMARK 465 SER L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 SER L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 THR L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 GLY L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 PHE L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 LYS L 142 REMARK 465 ASP L 143 REMARK 465 ILE L 144 REMARK 465 ASN L 145 REMARK 465 VAL L 146 REMARK 465 LYS L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 ILE L 150 REMARK 465 ASP L 151 REMARK 465 GLY L 152 REMARK 465 SER L 153 REMARK 465 GLU L 154 REMARK 465 ARG L 155 REMARK 465 GLN L 156 REMARK 465 ASN L 157 REMARK 465 GLY L 158 REMARK 465 VAL L 159 REMARK 465 LEU L 160 REMARK 465 ASN L 161 REMARK 465 SER L 162 REMARK 465 TRP L 163 REMARK 465 THR L 164 REMARK 465 ASP L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 MET L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 THR L 182 REMARK 465 LYS L 183 REMARK 465 ASP L 184 REMARK 465 GLU L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 ARG L 188 REMARK 465 HIS L 189 REMARK 465 ASN L 190 REMARK 465 SER L 191 REMARK 465 TYR L 192 REMARK 465 THR L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 ALA L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 LYS L 199 REMARK 465 THR L 200 REMARK 465 SER L 201 REMARK 465 THR L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 ILE L 205 REMARK 465 VAL L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 ASN L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 ALA E 114 REMARK 465 SER E 115 REMARK 465 THR E 116 REMARK 465 THR E 117 REMARK 465 PRO E 118 REMARK 465 PRO E 119 REMARK 465 SER E 120 REMARK 465 VAL E 121 REMARK 465 TYR E 122 REMARK 465 PRO E 123 REMARK 465 LEU E 124 REMARK 465 ALA E 125 REMARK 465 PRO E 126 REMARK 465 GLY E 127 REMARK 465 SER E 128 REMARK 465 ALA E 129 REMARK 465 ALA E 130 REMARK 465 GLN E 131 REMARK 465 THR E 132 REMARK 465 ASN E 133 REMARK 465 SER E 134 REMARK 465 MET E 135 REMARK 465 VAL E 136 REMARK 465 THR E 137 REMARK 465 LEU E 138 REMARK 465 GLY E 139 REMARK 465 CYS E 140 REMARK 465 LEU E 141 REMARK 465 VAL E 142 REMARK 465 LYS E 143 REMARK 465 GLY E 144 REMARK 465 TYR E 145 REMARK 465 PHE E 146 REMARK 465 PRO E 147 REMARK 465 GLU E 148 REMARK 465 PRO E 149 REMARK 465 VAL E 150 REMARK 465 THR E 151 REMARK 465 VAL E 152 REMARK 465 THR E 153 REMARK 465 TRP E 154 REMARK 465 ASN E 155 REMARK 465 SER E 156 REMARK 465 GLY E 157 REMARK 465 SER E 158 REMARK 465 LEU E 159 REMARK 465 SER E 160 REMARK 465 SER E 161 REMARK 465 GLY E 162 REMARK 465 VAL E 163 REMARK 465 HIS E 164 REMARK 465 THR E 165 REMARK 465 PHE E 166 REMARK 465 PRO E 167 REMARK 465 ALA E 168 REMARK 465 VAL E 169 REMARK 465 LEU E 170 REMARK 465 GLN E 171 REMARK 465 SER E 172 REMARK 465 ASP E 173 REMARK 465 LEU E 174 REMARK 465 TYR E 175 REMARK 465 THR E 176 REMARK 465 LEU E 177 REMARK 465 SER E 178 REMARK 465 SER E 179 REMARK 465 SER E 180 REMARK 465 VAL E 181 REMARK 465 THR E 182 REMARK 465 VAL E 183 REMARK 465 PRO E 184 REMARK 465 SER E 185 REMARK 465 SER E 186 REMARK 465 THR E 187 REMARK 465 TRP E 188 REMARK 465 PRO E 189 REMARK 465 SER E 190 REMARK 465 GLU E 191 REMARK 465 THR E 192 REMARK 465 VAL E 193 REMARK 465 THR E 194 REMARK 465 CYS E 195 REMARK 465 ASN E 196 REMARK 465 VAL E 197 REMARK 465 ALA E 198 REMARK 465 HIS E 199 REMARK 465 PRO E 200 REMARK 465 ALA E 201 REMARK 465 SER E 202 REMARK 465 SER E 203 REMARK 465 THR E 204 REMARK 465 LYS E 205 REMARK 465 VAL E 206 REMARK 465 ASP E 207 REMARK 465 LYS E 208 REMARK 465 LYS E 209 REMARK 465 ILE E 210 REMARK 465 VAL E 211 REMARK 465 PRO E 212 REMARK 465 ARG E 213 REMARK 465 ASP E 214 REMARK 465 CYS E 215 REMARK 465 ASP E 216 REMARK 465 LYS E 217 REMARK 465 GLY E 218 REMARK 465 LEU E 219 REMARK 465 GLU E 220 REMARK 465 VAL E 221 REMARK 465 LEU E 222 REMARK 465 PHE E 223 REMARK 465 GLN E 224 REMARK 465 ARG J 108 REMARK 465 THR J 109 REMARK 465 ASP J 110 REMARK 465 ALA J 111 REMARK 465 ALA J 112 REMARK 465 PRO J 113 REMARK 465 THR J 114 REMARK 465 VAL J 115 REMARK 465 SER J 116 REMARK 465 ILE J 117 REMARK 465 PHE J 118 REMARK 465 PRO J 119 REMARK 465 PRO J 120 REMARK 465 SER J 121 REMARK 465 SER J 122 REMARK 465 GLU J 123 REMARK 465 GLN J 124 REMARK 465 LEU J 125 REMARK 465 THR J 126 REMARK 465 SER J 127 REMARK 465 GLY J 128 REMARK 465 GLY J 129 REMARK 465 ALA J 130 REMARK 465 SER J 131 REMARK 465 VAL J 132 REMARK 465 VAL J 133 REMARK 465 CYS J 134 REMARK 465 PHE J 135 REMARK 465 LEU J 136 REMARK 465 ASN J 137 REMARK 465 ASN J 138 REMARK 465 PHE J 139 REMARK 465 TYR J 140 REMARK 465 PRO J 141 REMARK 465 LYS J 142 REMARK 465 ASP J 143 REMARK 465 ILE J 144 REMARK 465 ASN J 145 REMARK 465 VAL J 146 REMARK 465 LYS J 147 REMARK 465 TRP J 148 REMARK 465 LYS J 149 REMARK 465 ILE J 150 REMARK 465 ASP J 151 REMARK 465 GLY J 152 REMARK 465 SER J 153 REMARK 465 GLU J 154 REMARK 465 ARG J 155 REMARK 465 GLN J 156 REMARK 465 ASN J 157 REMARK 465 GLY J 158 REMARK 465 VAL J 159 REMARK 465 LEU J 160 REMARK 465 ASN J 161 REMARK 465 SER J 162 REMARK 465 TRP J 163 REMARK 465 THR J 164 REMARK 465 ASP J 165 REMARK 465 GLN J 166 REMARK 465 ASP J 167 REMARK 465 SER J 168 REMARK 465 LYS J 169 REMARK 465 ASP J 170 REMARK 465 SER J 171 REMARK 465 THR J 172 REMARK 465 TYR J 173 REMARK 465 SER J 174 REMARK 465 MET J 175 REMARK 465 SER J 176 REMARK 465 SER J 177 REMARK 465 THR J 178 REMARK 465 LEU J 179 REMARK 465 THR J 180 REMARK 465 LEU J 181 REMARK 465 THR J 182 REMARK 465 LYS J 183 REMARK 465 ASP J 184 REMARK 465 GLU J 185 REMARK 465 TYR J 186 REMARK 465 GLU J 187 REMARK 465 ARG J 188 REMARK 465 HIS J 189 REMARK 465 ASN J 190 REMARK 465 SER J 191 REMARK 465 TYR J 192 REMARK 465 THR J 193 REMARK 465 CYS J 194 REMARK 465 GLU J 195 REMARK 465 ALA J 196 REMARK 465 THR J 197 REMARK 465 HIS J 198 REMARK 465 LYS J 199 REMARK 465 THR J 200 REMARK 465 SER J 201 REMARK 465 THR J 202 REMARK 465 SER J 203 REMARK 465 PRO J 204 REMARK 465 ILE J 205 REMARK 465 VAL J 206 REMARK 465 LYS J 207 REMARK 465 SER J 208 REMARK 465 PHE J 209 REMARK 465 ASN J 210 REMARK 465 ARG J 211 REMARK 465 ASN J 212 REMARK 465 GLU J 213 REMARK 465 CYS J 214 REMARK 465 ALA F 114 REMARK 465 SER F 115 REMARK 465 THR F 116 REMARK 465 THR F 117 REMARK 465 PRO F 118 REMARK 465 PRO F 119 REMARK 465 SER F 120 REMARK 465 VAL F 121 REMARK 465 TYR F 122 REMARK 465 PRO F 123 REMARK 465 LEU F 124 REMARK 465 ALA F 125 REMARK 465 PRO F 126 REMARK 465 GLY F 127 REMARK 465 SER F 128 REMARK 465 ALA F 129 REMARK 465 ALA F 130 REMARK 465 GLN F 131 REMARK 465 THR F 132 REMARK 465 ASN F 133 REMARK 465 SER F 134 REMARK 465 MET F 135 REMARK 465 VAL F 136 REMARK 465 THR F 137 REMARK 465 LEU F 138 REMARK 465 GLY F 139 REMARK 465 CYS F 140 REMARK 465 LEU F 141 REMARK 465 VAL F 142 REMARK 465 LYS F 143 REMARK 465 GLY F 144 REMARK 465 TYR F 145 REMARK 465 PHE F 146 REMARK 465 PRO F 147 REMARK 465 GLU F 148 REMARK 465 PRO F 149 REMARK 465 VAL F 150 REMARK 465 THR F 151 REMARK 465 VAL F 152 REMARK 465 THR F 153 REMARK 465 TRP F 154 REMARK 465 ASN F 155 REMARK 465 SER F 156 REMARK 465 GLY F 157 REMARK 465 SER F 158 REMARK 465 LEU F 159 REMARK 465 SER F 160 REMARK 465 SER F 161 REMARK 465 GLY F 162 REMARK 465 VAL F 163 REMARK 465 HIS F 164 REMARK 465 THR F 165 REMARK 465 PHE F 166 REMARK 465 PRO F 167 REMARK 465 ALA F 168 REMARK 465 VAL F 169 REMARK 465 LEU F 170 REMARK 465 GLN F 171 REMARK 465 SER F 172 REMARK 465 ASP F 173 REMARK 465 LEU F 174 REMARK 465 TYR F 175 REMARK 465 THR F 176 REMARK 465 LEU F 177 REMARK 465 SER F 178 REMARK 465 SER F 179 REMARK 465 SER F 180 REMARK 465 VAL F 181 REMARK 465 THR F 182 REMARK 465 VAL F 183 REMARK 465 PRO F 184 REMARK 465 SER F 185 REMARK 465 SER F 186 REMARK 465 THR F 187 REMARK 465 TRP F 188 REMARK 465 PRO F 189 REMARK 465 SER F 190 REMARK 465 GLU F 191 REMARK 465 THR F 192 REMARK 465 VAL F 193 REMARK 465 THR F 194 REMARK 465 CYS F 195 REMARK 465 ASN F 196 REMARK 465 VAL F 197 REMARK 465 ALA F 198 REMARK 465 HIS F 199 REMARK 465 PRO F 200 REMARK 465 ALA F 201 REMARK 465 SER F 202 REMARK 465 SER F 203 REMARK 465 THR F 204 REMARK 465 LYS F 205 REMARK 465 VAL F 206 REMARK 465 ASP F 207 REMARK 465 LYS F 208 REMARK 465 LYS F 209 REMARK 465 ILE F 210 REMARK 465 VAL F 211 REMARK 465 PRO F 212 REMARK 465 ARG F 213 REMARK 465 ASP F 214 REMARK 465 CYS F 215 REMARK 465 ASP F 216 REMARK 465 LYS F 217 REMARK 465 GLY F 218 REMARK 465 LEU F 219 REMARK 465 GLU F 220 REMARK 465 VAL F 221 REMARK 465 LEU F 222 REMARK 465 PHE F 223 REMARK 465 GLN F 224 REMARK 465 ARG K 108 REMARK 465 THR K 109 REMARK 465 ASP K 110 REMARK 465 ALA K 111 REMARK 465 ALA K 112 REMARK 465 PRO K 113 REMARK 465 THR K 114 REMARK 465 VAL K 115 REMARK 465 SER K 116 REMARK 465 ILE K 117 REMARK 465 PHE K 118 REMARK 465 PRO K 119 REMARK 465 PRO K 120 REMARK 465 SER K 121 REMARK 465 SER K 122 REMARK 465 GLU K 123 REMARK 465 GLN K 124 REMARK 465 LEU K 125 REMARK 465 THR K 126 REMARK 465 SER K 127 REMARK 465 GLY K 128 REMARK 465 GLY K 129 REMARK 465 ALA K 130 REMARK 465 SER K 131 REMARK 465 VAL K 132 REMARK 465 VAL K 133 REMARK 465 CYS K 134 REMARK 465 PHE K 135 REMARK 465 LEU K 136 REMARK 465 ASN K 137 REMARK 465 ASN K 138 REMARK 465 PHE K 139 REMARK 465 TYR K 140 REMARK 465 PRO K 141 REMARK 465 LYS K 142 REMARK 465 ASP K 143 REMARK 465 ILE K 144 REMARK 465 ASN K 145 REMARK 465 VAL K 146 REMARK 465 LYS K 147 REMARK 465 TRP K 148 REMARK 465 LYS K 149 REMARK 465 ILE K 150 REMARK 465 ASP K 151 REMARK 465 GLY K 152 REMARK 465 SER K 153 REMARK 465 GLU K 154 REMARK 465 ARG K 155 REMARK 465 GLN K 156 REMARK 465 ASN K 157 REMARK 465 GLY K 158 REMARK 465 VAL K 159 REMARK 465 LEU K 160 REMARK 465 ASN K 161 REMARK 465 SER K 162 REMARK 465 TRP K 163 REMARK 465 THR K 164 REMARK 465 ASP K 165 REMARK 465 GLN K 166 REMARK 465 ASP K 167 REMARK 465 SER K 168 REMARK 465 LYS K 169 REMARK 465 ASP K 170 REMARK 465 SER K 171 REMARK 465 THR K 172 REMARK 465 TYR K 173 REMARK 465 SER K 174 REMARK 465 MET K 175 REMARK 465 SER K 176 REMARK 465 SER K 177 REMARK 465 THR K 178 REMARK 465 LEU K 179 REMARK 465 THR K 180 REMARK 465 LEU K 181 REMARK 465 THR K 182 REMARK 465 LYS K 183 REMARK 465 ASP K 184 REMARK 465 GLU K 185 REMARK 465 TYR K 186 REMARK 465 GLU K 187 REMARK 465 ARG K 188 REMARK 465 HIS K 189 REMARK 465 ASN K 190 REMARK 465 SER K 191 REMARK 465 TYR K 192 REMARK 465 THR K 193 REMARK 465 CYS K 194 REMARK 465 GLU K 195 REMARK 465 ALA K 196 REMARK 465 THR K 197 REMARK 465 HIS K 198 REMARK 465 LYS K 199 REMARK 465 THR K 200 REMARK 465 SER K 201 REMARK 465 THR K 202 REMARK 465 SER K 203 REMARK 465 PRO K 204 REMARK 465 ILE K 205 REMARK 465 VAL K 206 REMARK 465 LYS K 207 REMARK 465 SER K 208 REMARK 465 PHE K 209 REMARK 465 ASN K 210 REMARK 465 ARG K 211 REMARK 465 ASN K 212 REMARK 465 GLU K 213 REMARK 465 CYS K 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 NE ARG I 25 NE2 GLN I 34 2.12 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 63 51.53 33.46 REMARK 500 THR A 206 -169.37 -126.54 REMARK 500 ASN A 290 50.99 -90.66 REMARK 500 TYR B 141 49.43 -90.56 REMARK 500 LYS B 143 99.58 -69.83 REMARK 500 THR B 156 31.59 -93.71 REMARK 500 HIS B 159 22.64 48.33 REMARK 500 ASP B 160 -31.57 -131.67 REMARK 500 ASP C 7 -2.05 66.34 REMARK 500 THR C 28 -165.71 -120.73 REMARK 500 PHE C 79 57.77 -95.20 REMARK 500 CYS C 97 -166.37 -167.56 REMARK 500 THR C 318 53.45 -94.00 REMARK 500 ALA D 5 -64.42 -104.75 REMARK 500 GLU D 15 -1.93 67.27 REMARK 500 ARG D 127 -130.68 58.77 REMARK 500 ASN D 146 -8.28 74.05 REMARK 500 ASP D 160 -143.46 52.44 REMARK 500 PRO G 4 -177.86 -67.71 REMARK 500 ASN G 8 45.80 -90.81 REMARK 500 SER G 9 -15.45 -140.75 REMARK 500 GLU G 62 -143.46 57.04 REMARK 500 THR G 206 -167.97 -124.66 REMARK 500 CYS G 277 -159.82 -149.89 REMARK 500 ASN G 290 50.60 -91.02 REMARK 500 ARG I 127 -123.31 58.93 REMARK 500 HIS I 142 -75.85 -92.17 REMARK 500 ASN I 146 31.48 -142.23 REMARK 500 ARG I 153 49.12 -90.01 REMARK 500 HIS I 159 23.17 48.66 REMARK 500 ASN I 168 -3.17 -140.51 REMARK 500 PHE H 63 55.60 -93.30 REMARK 500 ASN L 31 30.07 70.79 REMARK 500 THR L 51 -7.35 71.77 REMARK 500 ASN J 31 22.83 -144.20 REMARK 500 TYR J 32 30.64 -95.55 REMARK 500 THR J 51 -11.87 71.68 REMARK 500 ILE F 48 -60.13 -95.05 REMARK 500 TYR F 97 -168.66 -161.20 REMARK 500 TYR K 50 -145.76 54.21 REMARK 500 SER K 91 49.07 -148.82 REMARK 500 REMARK 500 REMARK: NULL REMARK 610 REMARK 610 MISSING HETEROATOM REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 610 I=INSERTION CODE): REMARK 610 M RES C SSEQI REMARK 610 NAG M 1 REMARK 610 NAG N 1 REMARK 610 NAG O 1 REMARK 610 NAG P 1 REMARK 610 NAG Q 1 REMARK 610 NAG U 1 REMARK 610 NAG V 1 REMARK 610 NAG W 1 REMARK 610 NAG X 1 REMARK 610 NAG A 401 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-41676 RELATED DB: EMDB REMARK 900 FAB 3864-6 IN COMPLEX WITH INFLUENZA HA H3-VIC11 DBREF 8TX3 A -15 329 UNP L0HR89 L0HR89_9INFA 1 345 DBREF 8TX3 B 1 176 UNP L0HR89 L0HR89_9INFA 346 521 DBREF 8TX3 C -15 329 UNP L0HR89 L0HR89_9INFA 1 345 DBREF 8TX3 D 1 176 UNP L0HR89 L0HR89_9INFA 346 521 DBREF 8TX3 G -15 329 UNP L0HR89 L0HR89_9INFA 1 345 DBREF 8TX3 I 1 176 UNP L0HR89 L0HR89_9INFA 346 521 DBREF 8TX3 H 1 224 PDB 8TX3 8TX3 1 224 DBREF 8TX3 L 1 214 PDB 8TX3 8TX3 1 214 DBREF 8TX3 E 1 224 PDB 8TX3 8TX3 1 224 DBREF 8TX3 J 1 214 PDB 8TX3 8TX3 1 214 DBREF 8TX3 F 1 224 PDB 8TX3 8TX3 1 224 DBREF 8TX3 K 1 214 PDB 8TX3 8TX3 1 214 SEQADV 8TX3 CYS A 30 UNP L0HR89 THR 46 CONFLICT SEQADV 8TX3 ARG A 330 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG A 331 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG A 332 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG A 333 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG A 334 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 CYS B 47 UNP L0HR89 GLN 392 CONFLICT SEQADV 8TX3 SER B 177 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY B 178 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG B 179 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU B 180 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL B 181 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO B 182 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG B 183 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY B 184 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER B 185 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO B 186 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY B 187 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER B 188 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY B 189 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TYR B 190 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ILE B 191 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO B 192 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLU B 193 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ALA B 194 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO B 195 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG B 196 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ASP B 197 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY B 198 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLN B 199 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ALA B 200 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TYR B 201 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL B 202 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG B 203 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LYS B 204 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ASP B 205 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY B 206 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLU B 207 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TRP B 208 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL B 209 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU B 210 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU B 211 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER B 212 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 THR B 213 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PHE B 214 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU B 215 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY B 216 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS B 217 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS B 218 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS B 219 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS B 220 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS B 221 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS B 222 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 CYS C 30 UNP L0HR89 THR 46 CONFLICT SEQADV 8TX3 ARG C 330 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG C 331 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG C 332 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG C 333 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG C 334 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 CYS D 47 UNP L0HR89 GLN 392 CONFLICT SEQADV 8TX3 SER D 177 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY D 178 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG D 179 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU D 180 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL D 181 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO D 182 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG D 183 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY D 184 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER D 185 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO D 186 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY D 187 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER D 188 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY D 189 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TYR D 190 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ILE D 191 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO D 192 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLU D 193 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ALA D 194 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO D 195 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG D 196 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ASP D 197 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY D 198 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLN D 199 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ALA D 200 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TYR D 201 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL D 202 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG D 203 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LYS D 204 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ASP D 205 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY D 206 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLU D 207 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TRP D 208 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL D 209 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU D 210 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU D 211 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER D 212 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 THR D 213 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PHE D 214 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU D 215 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY D 216 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS D 217 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS D 218 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS D 219 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS D 220 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS D 221 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS D 222 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 CYS G 30 UNP L0HR89 THR 46 CONFLICT SEQADV 8TX3 ARG G 330 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG G 331 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG G 332 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG G 333 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG G 334 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 CYS I 47 UNP L0HR89 GLN 392 CONFLICT SEQADV 8TX3 SER I 177 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY I 178 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG I 179 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU I 180 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL I 181 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO I 182 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG I 183 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY I 184 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER I 185 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO I 186 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY I 187 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER I 188 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY I 189 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TYR I 190 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ILE I 191 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO I 192 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLU I 193 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ALA I 194 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PRO I 195 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG I 196 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ASP I 197 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY I 198 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLN I 199 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ALA I 200 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TYR I 201 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL I 202 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ARG I 203 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LYS I 204 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 ASP I 205 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY I 206 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLU I 207 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 TRP I 208 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 VAL I 209 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU I 210 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU I 211 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 SER I 212 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 THR I 213 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 PHE I 214 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 LEU I 215 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 GLY I 216 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS I 217 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS I 218 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS I 219 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS I 220 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS I 221 UNP L0HR89 EXPRESSION TAG SEQADV 8TX3 HIS I 222 UNP L0HR89 EXPRESSION TAG SEQRES 1 A 350 MET LYS THR ILE ILE ALA LEU SER HIS ILE LEU CYS LEU SEQRES 2 A 350 VAL PHE ALA GLN LYS LEU PRO GLY ASN ASP ASN SER THR SEQRES 3 A 350 ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO ASN GLY SEQRES 4 A 350 THR ILE VAL LYS THR ILE CYS ASN ASP GLN ILE GLU VAL SEQRES 5 A 350 THR ASN ALA THR GLU LEU VAL GLN ASN SER SER ILE GLY SEQRES 6 A 350 GLU ILE CYS ASP SER PRO HIS GLN ILE LEU ASP GLY GLU SEQRES 7 A 350 ASN CYS THR LEU ILE ASP ALA LEU LEU GLY ASP PRO GLN SEQRES 8 A 350 CYS ASP GLY PHE GLN ASN LYS LYS TRP ASP LEU PHE VAL SEQRES 9 A 350 GLU ARG SER LYS ALA TYR SER ASN CYS TYR PRO TYR ASP SEQRES 10 A 350 VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL ALA SER SEQRES 11 A 350 SER GLY THR LEU GLU PHE ASN ASN GLU SER PHE ASN TRP SEQRES 12 A 350 THR GLY VAL THR GLN ASN GLY THR SER SER ALA CYS ILE SEQRES 13 A 350 ARG ARG SER ASN ASN SER PHE PHE SER ARG LEU ASN TRP SEQRES 14 A 350 LEU THR GLN LEU ASN PHE LYS TYR PRO ALA LEU ASN VAL SEQRES 15 A 350 THR MET PRO ASN ASN GLU GLN PHE ASP LYS LEU TYR ILE SEQRES 16 A 350 TRP GLY VAL HIS HIS PRO VAL THR ASP LYS ASP GLN ILE SEQRES 17 A 350 PHE LEU TYR ALA GLN SER SER GLY ARG ILE THR VAL SER SEQRES 18 A 350 THR LYS ARG SER GLN GLN ALA VAL ILE PRO ASN ILE GLY SEQRES 19 A 350 TYR ARG PRO ARG ILE ARG ASN ILE PRO SER ARG ILE SER SEQRES 20 A 350 ILE TYR TRP THR ILE VAL LYS PRO GLY ASP ILE LEU LEU SEQRES 21 A 350 ILE ASN SER THR GLY ASN LEU ILE ALA PRO ARG GLY TYR SEQRES 22 A 350 PHE LYS ILE ARG SER GLY LYS SER SER ILE MET ARG SER SEQRES 23 A 350 ASP ALA PRO ILE GLY LYS CYS ASN SER GLU CYS ILE THR SEQRES 24 A 350 PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE GLN ASN SEQRES 25 A 350 VAL ASN ARG ILE THR TYR GLY ALA CYS PRO ARG TYR VAL SEQRES 26 A 350 LYS GLN SER THR LEU LYS LEU ALA THR GLY MET ARG ASN SEQRES 27 A 350 VAL PRO GLU LYS GLN THR ARG ARG ARG ARG ARG ARG SEQRES 1 B 222 GLY ILE PHE GLY ALA ILE ALA GLY PHE ILE GLU ASN GLY SEQRES 2 B 222 TRP GLU GLY MET VAL ASP GLY TRP TYR GLY PHE ARG HIS SEQRES 3 B 222 GLN ASN SER GLU GLY ARG GLY GLN ALA ALA ASP LEU LYS SEQRES 4 B 222 SER THR GLN ALA ALA ILE ASP CYS ILE ASN GLY LYS LEU SEQRES 5 B 222 ASN ARG LEU ILE GLY LYS THR ASN GLU LYS PHE HIS GLN SEQRES 6 B 222 ILE GLU LYS GLU PHE SER GLU VAL GLU GLY ARG ILE GLN SEQRES 7 B 222 ASP LEU GLU LYS TYR VAL GLU ASP THR LYS ILE ASP LEU SEQRES 8 B 222 TRP SER TYR ASN ALA GLU LEU LEU VAL ALA LEU GLU ASN SEQRES 9 B 222 GLN HIS THR ILE ASP LEU THR ASP SER GLU MET ASN LYS SEQRES 10 B 222 LEU PHE GLU LYS THR LYS LYS GLN LEU ARG GLU ASN ALA SEQRES 11 B 222 GLU ASP MET GLY ASN GLY CYS PHE LYS ILE TYR HIS LYS SEQRES 12 B 222 CYS ASP ASN ALA CYS ILE GLY SER ILE ARG ASN GLY THR SEQRES 13 B 222 TYR ASP HIS ASP VAL TYR ARG ASP GLU ALA LEU ASN ASN SEQRES 14 B 222 ARG PHE GLN ILE LYS GLY VAL SER GLY ARG LEU VAL PRO SEQRES 15 B 222 ARG GLY SER PRO GLY SER GLY TYR ILE PRO GLU ALA PRO SEQRES 16 B 222 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP SEQRES 17 B 222 VAL LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS HIS SEQRES 18 B 222 HIS SEQRES 1 C 350 MET LYS THR ILE ILE ALA LEU SER HIS ILE LEU CYS LEU SEQRES 2 C 350 VAL PHE ALA GLN LYS LEU PRO GLY ASN ASP ASN SER THR SEQRES 3 C 350 ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO ASN GLY SEQRES 4 C 350 THR ILE VAL LYS THR ILE CYS ASN ASP GLN ILE GLU VAL SEQRES 5 C 350 THR ASN ALA THR GLU LEU VAL GLN ASN SER SER ILE GLY SEQRES 6 C 350 GLU ILE CYS ASP SER PRO HIS GLN ILE LEU ASP GLY GLU SEQRES 7 C 350 ASN CYS THR LEU ILE ASP ALA LEU LEU GLY ASP PRO GLN SEQRES 8 C 350 CYS ASP GLY PHE GLN ASN LYS LYS TRP ASP LEU PHE VAL SEQRES 9 C 350 GLU ARG SER LYS ALA TYR SER ASN CYS TYR PRO TYR ASP SEQRES 10 C 350 VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL ALA SER SEQRES 11 C 350 SER GLY THR LEU GLU PHE ASN ASN GLU SER PHE ASN TRP SEQRES 12 C 350 THR GLY VAL THR GLN ASN GLY THR SER SER ALA CYS ILE SEQRES 13 C 350 ARG ARG SER ASN ASN SER PHE PHE SER ARG LEU ASN TRP SEQRES 14 C 350 LEU THR GLN LEU ASN PHE LYS TYR PRO ALA LEU ASN VAL SEQRES 15 C 350 THR MET PRO ASN ASN GLU GLN PHE ASP LYS LEU TYR ILE SEQRES 16 C 350 TRP GLY VAL HIS HIS PRO VAL THR ASP LYS ASP GLN ILE SEQRES 17 C 350 PHE LEU TYR ALA GLN SER SER GLY ARG ILE THR VAL SER SEQRES 18 C 350 THR LYS ARG SER GLN GLN ALA VAL ILE PRO ASN ILE GLY SEQRES 19 C 350 TYR ARG PRO ARG ILE ARG ASN ILE PRO SER ARG ILE SER SEQRES 20 C 350 ILE TYR TRP THR ILE VAL LYS PRO GLY ASP ILE LEU LEU SEQRES 21 C 350 ILE ASN SER THR GLY ASN LEU ILE ALA PRO ARG GLY TYR SEQRES 22 C 350 PHE LYS ILE ARG SER GLY LYS SER SER ILE MET ARG SER SEQRES 23 C 350 ASP ALA PRO ILE GLY LYS CYS ASN SER GLU CYS ILE THR SEQRES 24 C 350 PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE GLN ASN SEQRES 25 C 350 VAL ASN ARG ILE THR TYR GLY ALA CYS PRO ARG TYR VAL SEQRES 26 C 350 LYS GLN SER THR LEU LYS LEU ALA THR GLY MET ARG ASN SEQRES 27 C 350 VAL PRO GLU LYS GLN THR ARG ARG ARG ARG ARG ARG SEQRES 1 D 222 GLY ILE PHE GLY ALA ILE ALA GLY PHE ILE GLU ASN GLY SEQRES 2 D 222 TRP GLU GLY MET VAL ASP GLY TRP TYR GLY PHE ARG HIS SEQRES 3 D 222 GLN ASN SER GLU GLY ARG GLY GLN ALA ALA ASP LEU LYS SEQRES 4 D 222 SER THR GLN ALA ALA ILE ASP CYS ILE ASN GLY LYS LEU SEQRES 5 D 222 ASN ARG LEU ILE GLY LYS THR ASN GLU LYS PHE HIS GLN SEQRES 6 D 222 ILE GLU LYS GLU PHE SER GLU VAL GLU GLY ARG ILE GLN SEQRES 7 D 222 ASP LEU GLU LYS TYR VAL GLU ASP THR LYS ILE ASP LEU SEQRES 8 D 222 TRP SER TYR ASN ALA GLU LEU LEU VAL ALA LEU GLU ASN SEQRES 9 D 222 GLN HIS THR ILE ASP LEU THR ASP SER GLU MET ASN LYS SEQRES 10 D 222 LEU PHE GLU LYS THR LYS LYS GLN LEU ARG GLU ASN ALA SEQRES 11 D 222 GLU ASP MET GLY ASN GLY CYS PHE LYS ILE TYR HIS LYS SEQRES 12 D 222 CYS ASP ASN ALA CYS ILE GLY SER ILE ARG ASN GLY THR SEQRES 13 D 222 TYR ASP HIS ASP VAL TYR ARG ASP GLU ALA LEU ASN ASN SEQRES 14 D 222 ARG PHE GLN ILE LYS GLY VAL SER GLY ARG LEU VAL PRO SEQRES 15 D 222 ARG GLY SER PRO GLY SER GLY TYR ILE PRO GLU ALA PRO SEQRES 16 D 222 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP SEQRES 17 D 222 VAL LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS HIS SEQRES 18 D 222 HIS SEQRES 1 G 350 MET LYS THR ILE ILE ALA LEU SER HIS ILE LEU CYS LEU SEQRES 2 G 350 VAL PHE ALA GLN LYS LEU PRO GLY ASN ASP ASN SER THR SEQRES 3 G 350 ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO ASN GLY SEQRES 4 G 350 THR ILE VAL LYS THR ILE CYS ASN ASP GLN ILE GLU VAL SEQRES 5 G 350 THR ASN ALA THR GLU LEU VAL GLN ASN SER SER ILE GLY SEQRES 6 G 350 GLU ILE CYS ASP SER PRO HIS GLN ILE LEU ASP GLY GLU SEQRES 7 G 350 ASN CYS THR LEU ILE ASP ALA LEU LEU GLY ASP PRO GLN SEQRES 8 G 350 CYS ASP GLY PHE GLN ASN LYS LYS TRP ASP LEU PHE VAL SEQRES 9 G 350 GLU ARG SER LYS ALA TYR SER ASN CYS TYR PRO TYR ASP SEQRES 10 G 350 VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL ALA SER SEQRES 11 G 350 SER GLY THR LEU GLU PHE ASN ASN GLU SER PHE ASN TRP SEQRES 12 G 350 THR GLY VAL THR GLN ASN GLY THR SER SER ALA CYS ILE SEQRES 13 G 350 ARG ARG SER ASN ASN SER PHE PHE SER ARG LEU ASN TRP SEQRES 14 G 350 LEU THR GLN LEU ASN PHE LYS TYR PRO ALA LEU ASN VAL SEQRES 15 G 350 THR MET PRO ASN ASN GLU GLN PHE ASP LYS LEU TYR ILE SEQRES 16 G 350 TRP GLY VAL HIS HIS PRO VAL THR ASP LYS ASP GLN ILE SEQRES 17 G 350 PHE LEU TYR ALA GLN SER SER GLY ARG ILE THR VAL SER SEQRES 18 G 350 THR LYS ARG SER GLN GLN ALA VAL ILE PRO ASN ILE GLY SEQRES 19 G 350 TYR ARG PRO ARG ILE ARG ASN ILE PRO SER ARG ILE SER SEQRES 20 G 350 ILE TYR TRP THR ILE VAL LYS PRO GLY ASP ILE LEU LEU SEQRES 21 G 350 ILE ASN SER THR GLY ASN LEU ILE ALA PRO ARG GLY TYR SEQRES 22 G 350 PHE LYS ILE ARG SER GLY LYS SER SER ILE MET ARG SER SEQRES 23 G 350 ASP ALA PRO ILE GLY LYS CYS ASN SER GLU CYS ILE THR SEQRES 24 G 350 PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE GLN ASN SEQRES 25 G 350 VAL ASN ARG ILE THR TYR GLY ALA CYS PRO ARG TYR VAL SEQRES 26 G 350 LYS GLN SER THR LEU LYS LEU ALA THR GLY MET ARG ASN SEQRES 27 G 350 VAL PRO GLU LYS GLN THR ARG ARG ARG ARG ARG ARG SEQRES 1 I 222 GLY ILE PHE GLY ALA ILE ALA GLY PHE ILE GLU ASN GLY SEQRES 2 I 222 TRP GLU GLY MET VAL ASP GLY TRP TYR GLY PHE ARG HIS SEQRES 3 I 222 GLN ASN SER GLU GLY ARG GLY GLN ALA ALA ASP LEU LYS SEQRES 4 I 222 SER THR GLN ALA ALA ILE ASP CYS ILE ASN GLY LYS LEU SEQRES 5 I 222 ASN ARG LEU ILE GLY LYS THR ASN GLU LYS PHE HIS GLN SEQRES 6 I 222 ILE GLU LYS GLU PHE SER GLU VAL GLU GLY ARG ILE GLN SEQRES 7 I 222 ASP LEU GLU LYS TYR VAL GLU ASP THR LYS ILE ASP LEU SEQRES 8 I 222 TRP SER TYR ASN ALA GLU LEU LEU VAL ALA LEU GLU ASN SEQRES 9 I 222 GLN HIS THR ILE ASP LEU THR ASP SER GLU MET ASN LYS SEQRES 10 I 222 LEU PHE GLU LYS THR LYS LYS GLN LEU ARG GLU ASN ALA SEQRES 11 I 222 GLU ASP MET GLY ASN GLY CYS PHE LYS ILE TYR HIS LYS SEQRES 12 I 222 CYS ASP ASN ALA CYS ILE GLY SER ILE ARG ASN GLY THR SEQRES 13 I 222 TYR ASP HIS ASP VAL TYR ARG ASP GLU ALA LEU ASN ASN SEQRES 14 I 222 ARG PHE GLN ILE LYS GLY VAL SER GLY ARG LEU VAL PRO SEQRES 15 I 222 ARG GLY SER PRO GLY SER GLY TYR ILE PRO GLU ALA PRO SEQRES 16 I 222 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP SEQRES 17 I 222 VAL LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS HIS SEQRES 18 I 222 HIS SEQRES 1 H 230 GLN VAL GLN LEU GLN GLN SER GLY THR ASP LEU VAL MET SEQRES 2 H 230 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA SER GLY SEQRES 3 H 230 TYR THR PHE ILE SER TRP TRP ILE HIS TRP VAL LYS GLN SEQRES 4 H 230 ARG PRO GLY GLN GLY LEU GLU TRP ILE GLY GLU ILE ASP SEQRES 5 H 230 PRO SER ASP SER TYR THR SER TYR ASN GLN LYS PHE LYS SEQRES 6 H 230 GLY LYS ALA THR LEU THR VAL ASP LYS SER SER SER THR SEQRES 7 H 230 ALA TYR MET GLN LEU SER SER LEU THR SER GLU ASP SER SEQRES 8 H 230 ALA VAL TYR TYR CYS ALA ARG SER GLY TYR SER ASN TYR SEQRES 9 H 230 PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU PRO VAL SEQRES 10 H 230 SER SER ALA SER THR THR PRO PRO SER VAL TYR PRO LEU SEQRES 11 H 230 ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL THR SEQRES 12 H 230 LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO VAL SEQRES 13 H 230 THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY VAL SEQRES 14 H 230 HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR THR SEQRES 15 H 230 LEU SER SER SER VAL THR VAL PRO SER SER THR TRP PRO SEQRES 16 H 230 SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SER SEQRES 17 H 230 SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP CYS SEQRES 18 H 230 ASP LYS GLY LEU GLU VAL LEU PHE GLN SEQRES 1 L 214 ASP ILE GLN MET THR GLN THR THR SER SER LEU SER ALA SEQRES 2 L 214 SER LEU GLY ASP ARG VAL THR ILE SER CYS SER ALA SER SEQRES 3 L 214 GLN GLY ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 L 214 PRO ASP GLY THR VAL LYS LEU LEU ILE TYR TYR THR SER SEQRES 5 L 214 SER LEU HIS SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 214 GLY SER GLY THR ASP TYR SER LEU THR ILE SER ASN LEU SEQRES 7 L 214 GLU PRO GLU ASP ILE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 L 214 SER LYS LEU PRO TRP THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 L 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 L 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 L 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 L 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 L 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 L 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 L 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 L 214 PHE ASN ARG ASN GLU CYS SEQRES 1 E 230 GLN VAL GLN LEU GLN GLN SER GLY THR ASP LEU VAL MET SEQRES 2 E 230 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA SER GLY SEQRES 3 E 230 TYR THR PHE ILE SER TRP TRP ILE HIS TRP VAL LYS GLN SEQRES 4 E 230 ARG PRO GLY GLN GLY LEU GLU TRP ILE GLY GLU ILE ASP SEQRES 5 E 230 PRO SER ASP SER TYR THR SER TYR ASN GLN LYS PHE LYS SEQRES 6 E 230 GLY LYS ALA THR LEU THR VAL ASP LYS SER SER SER THR SEQRES 7 E 230 ALA TYR MET GLN LEU SER SER LEU THR SER GLU ASP SER SEQRES 8 E 230 ALA VAL TYR TYR CYS ALA ARG SER GLY TYR SER ASN TYR SEQRES 9 E 230 PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU PRO VAL SEQRES 10 E 230 SER SER ALA SER THR THR PRO PRO SER VAL TYR PRO LEU SEQRES 11 E 230 ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL THR SEQRES 12 E 230 LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO VAL SEQRES 13 E 230 THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY VAL SEQRES 14 E 230 HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR THR SEQRES 15 E 230 LEU SER SER SER VAL THR VAL PRO SER SER THR TRP PRO SEQRES 16 E 230 SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SER SEQRES 17 E 230 SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP CYS SEQRES 18 E 230 ASP LYS GLY LEU GLU VAL LEU PHE GLN SEQRES 1 J 214 ASP ILE GLN MET THR GLN THR THR SER SER LEU SER ALA SEQRES 2 J 214 SER LEU GLY ASP ARG VAL THR ILE SER CYS SER ALA SER SEQRES 3 J 214 GLN GLY ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 J 214 PRO ASP GLY THR VAL LYS LEU LEU ILE TYR TYR THR SER SEQRES 5 J 214 SER LEU HIS SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 J 214 GLY SER GLY THR ASP TYR SER LEU THR ILE SER ASN LEU SEQRES 7 J 214 GLU PRO GLU ASP ILE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 J 214 SER LYS LEU PRO TRP THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 J 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 J 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 J 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 J 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 J 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 J 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 J 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 J 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 J 214 PHE ASN ARG ASN GLU CYS SEQRES 1 F 230 GLN VAL GLN LEU GLN GLN SER GLY THR ASP LEU VAL MET SEQRES 2 F 230 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA SER GLY SEQRES 3 F 230 TYR THR PHE ILE SER TRP TRP ILE HIS TRP VAL LYS GLN SEQRES 4 F 230 ARG PRO GLY GLN GLY LEU GLU TRP ILE GLY GLU ILE ASP SEQRES 5 F 230 PRO SER ASP SER TYR THR SER TYR ASN GLN LYS PHE LYS SEQRES 6 F 230 GLY LYS ALA THR LEU THR VAL ASP LYS SER SER SER THR SEQRES 7 F 230 ALA TYR MET GLN LEU SER SER LEU THR SER GLU ASP SER SEQRES 8 F 230 ALA VAL TYR TYR CYS ALA ARG SER GLY TYR SER ASN TYR SEQRES 9 F 230 PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU PRO VAL SEQRES 10 F 230 SER SER ALA SER THR THR PRO PRO SER VAL TYR PRO LEU SEQRES 11 F 230 ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL THR SEQRES 12 F 230 LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO VAL SEQRES 13 F 230 THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY VAL SEQRES 14 F 230 HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR THR SEQRES 15 F 230 LEU SER SER SER VAL THR VAL PRO SER SER THR TRP PRO SEQRES 16 F 230 SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SER SEQRES 17 F 230 SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP CYS SEQRES 18 F 230 ASP LYS GLY LEU GLU VAL LEU PHE GLN SEQRES 1 K 214 ASP ILE GLN MET THR GLN THR THR SER SER LEU SER ALA SEQRES 2 K 214 SER LEU GLY ASP ARG VAL THR ILE SER CYS SER ALA SER SEQRES 3 K 214 GLN GLY ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 K 214 PRO ASP GLY THR VAL LYS LEU LEU ILE TYR TYR THR SER SEQRES 5 K 214 SER LEU HIS SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 K 214 GLY SER GLY THR ASP TYR SER LEU THR ILE SER ASN LEU SEQRES 7 K 214 GLU PRO GLU ASP ILE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 K 214 SER LYS LEU PRO TRP THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 K 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 K 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 K 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 K 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 K 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 K 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 K 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 K 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 K 214 PHE ASN ARG ASN GLU CYS HET NAG M 1 14 HET NAG M 2 14 HET BMA M 3 11 HET MAN M 4 11 HET MAN M 5 11 HET NAG N 1 14 HET NAG N 2 14 HET BMA N 3 11 HET MAN N 4 11 HET MAN N 5 11 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET MAN O 4 11 HET MAN O 5 11 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET NAG Q 1 14 HET NAG Q 2 14 HET BMA Q 3 11 HET MAN Q 4 11 HET MAN Q 5 11 HET NAG R 1 14 HET NAG R 2 14 HET BMA R 3 11 HET MAN R 4 11 HET MAN R 5 11 HET NAG S 1 14 HET NAG S 2 14 HET BMA S 3 11 HET MAN S 4 11 HET MAN S 5 11 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET NAG V 1 14 HET NAG V 2 14 HET BMA V 3 11 HET MAN V 4 11 HET MAN V 5 11 HET NAG W 1 14 HET NAG W 2 14 HET BMA W 3 11 HET MAN W 4 11 HET MAN W 5 11 HET NAG X 1 14 HET NAG X 2 14 HET BMA X 3 11 HET NAG A 401 14 HET NAG A 402 14 HET NAG A 403 14 HET NAG A 404 14 HET NAG B 301 14 HET NAG C 401 14 HET NAG C 402 14 HET NAG C 403 14 HET NAG C 404 14 HET NAG D 301 14 HET NAG G 401 14 HET NAG G 402 14 HET NAG G 403 14 HET NAG G 404 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 13 NAG 38(C8 H15 N O6) FORMUL 13 BMA 12(C6 H12 O6) FORMUL 13 MAN 18(C6 H12 O6) HELIX 1 AA1 THR A 65 GLY A 72 1 8 HELIX 2 AA2 ASP A 73 GLN A 80 5 8 HELIX 3 AA3 ASP A 104 GLY A 116 1 13 HELIX 4 AA4 THR A 187 ALA A 196 1 10 HELIX 5 AA5 LEU B 38 ILE B 56 1 19 HELIX 6 AA6 GLY B 75 LEU B 126 1 52 HELIX 7 AA7 ASP B 145 GLY B 155 1 11 HELIX 8 AA8 TYR B 162 GLN B 172 1 11 HELIX 9 AA9 THR C 65 GLY C 72 1 8 HELIX 10 AB1 ASP C 73 ASP C 77 5 5 HELIX 11 AB2 ASP C 104 GLY C 116 1 13 HELIX 12 AB3 THR C 187 ALA C 196 1 10 HELIX 13 AB4 LEU D 38 ILE D 56 1 19 HELIX 14 AB5 GLY D 75 ARG D 127 1 53 HELIX 15 AB6 ASN D 146 GLY D 155 1 10 HELIX 16 AB7 ARG D 163 PHE D 171 1 9 HELIX 17 AB8 THR G 65 GLY G 72 1 8 HELIX 18 AB9 ASP G 73 GLN G 80 5 8 HELIX 19 AC1 ASP G 104 GLY G 116 1 13 HELIX 20 AC2 THR G 187 ALA G 196 1 10 HELIX 21 AC3 LEU I 38 ILE I 56 1 19 HELIX 22 AC4 GLY I 75 ARG I 127 1 53 HELIX 23 AC5 THR H 28 TRP H 32 5 5 HELIX 24 AC6 THR H 83 SER H 87 5 5 HELIX 25 AC7 GLU L 79 ILE L 83 5 5 HELIX 26 AC8 THR E 83 SER E 87 5 5 HELIX 27 AC9 GLU J 79 ILE J 83 5 5 HELIX 28 AD1 THR F 83 SER F 87 5 5 HELIX 29 AD2 GLU K 79 ILE K 83 5 5 SHEET 1 AA1 5 GLY B 31 ASP B 37 0 SHEET 2 AA1 5 TYR B 22 ASN B 28 -1 N TYR B 22 O ASP B 37 SHEET 3 AA1 5 ALA A 11 HIS A 17 -1 N CYS A 14 O ARG B 25 SHEET 4 AA1 5 PHE B 138 ILE B 140 -1 O ILE B 140 N ALA A 11 SHEET 5 AA1 5 ALA B 130 ASP B 132 -1 N GLU B 131 O LYS B 139 SHEET 1 AA2 2 THR A 24 VAL A 26 0 SHEET 2 AA2 2 ILE A 34 VAL A 36 -1 O VAL A 36 N THR A 24 SHEET 1 AA3 2 ALA A 39 GLU A 41 0 SHEET 2 AA3 2 LYS A 315 ALA A 317 -1 O LEU A 316 N THR A 40 SHEET 1 AA4 3 VAL A 43 GLN A 44 0 SHEET 2 AA4 3 PHE A 294 GLN A 295 1 O PHE A 294 N GLN A 44 SHEET 3 AA4 3 ARG A 307 TYR A 308 1 O ARG A 307 N GLN A 295 SHEET 1 AA5 2 ILE A 51 CYS A 52 0 SHEET 2 AA5 2 ILE A 274 GLY A 275 1 O GLY A 275 N ILE A 51 SHEET 1 AA6 3 ILE A 58 LEU A 59 0 SHEET 2 AA6 3 LEU A 86 GLU A 89 1 O LEU A 86 N LEU A 59 SHEET 3 AA6 3 SER A 266 ARG A 269 1 O MET A 268 N GLU A 89 SHEET 1 AA7 2 PHE A 120 ASN A 122 0 SHEET 2 AA7 2 GLY A 256 PHE A 258 -1 O TYR A 257 N ASN A 121 SHEET 1 AA8 2 SER A 136 ILE A 140 0 SHEET 2 AA8 2 ASN A 145 SER A 146 -1 O SER A 146 N SER A 136 SHEET 1 AA9 4 LEU A 151 TRP A 153 0 SHEET 2 AA9 4 LEU A 251 PRO A 254 -1 O ALA A 253 N ASN A 152 SHEET 3 AA9 4 LYS A 176 HIS A 184 -1 N GLY A 181 O ILE A 252 SHEET 4 AA9 4 ARG A 229 VAL A 237 -1 O THR A 235 N TYR A 178 SHEET 1 AB1 4 LEU A 164 PRO A 169 0 SHEET 2 AB1 4 ILE A 242 SER A 247 -1 O SER A 247 N LEU A 164 SHEET 3 AB1 4 ILE A 202 SER A 205 -1 N SER A 205 O LEU A 244 SHEET 4 AB1 4 GLN A 210 VAL A 213 -1 O VAL A 213 N ILE A 202 SHEET 1 AB2 2 GLY A 303 ALA A 304 0 SHEET 2 AB2 2 GLU B 61 LYS B 62 -1 O LYS B 62 N GLY A 303 SHEET 1 AB3 5 GLY D 31 ASP D 37 0 SHEET 2 AB3 5 TYR D 22 ASN D 28 -1 N TYR D 22 O ASP D 37 SHEET 3 AB3 5 ALA C 11 HIS C 17 -1 N CYS C 14 O ARG D 25 SHEET 4 AB3 5 CYS D 137 ILE D 140 -1 O ILE D 140 N ALA C 11 SHEET 5 AB3 5 ALA D 130 ASP D 132 -1 N GLU D 131 O LYS D 139 SHEET 1 AB4 2 THR C 24 VAL C 26 0 SHEET 2 AB4 2 ILE C 34 VAL C 36 -1 O ILE C 34 N VAL C 26 SHEET 1 AB5 2 THR C 40 GLU C 41 0 SHEET 2 AB5 2 LYS C 315 LEU C 316 -1 O LEU C 316 N THR C 40 SHEET 1 AB6 3 VAL C 43 GLN C 44 0 SHEET 2 AB6 3 PHE C 294 GLN C 295 1 O PHE C 294 N GLN C 44 SHEET 3 AB6 3 ARG C 307 TYR C 308 1 O ARG C 307 N GLN C 295 SHEET 1 AB7 2 ILE C 51 CYS C 52 0 SHEET 2 AB7 2 ILE C 274 GLY C 275 1 O GLY C 275 N ILE C 51 SHEET 1 AB8 3 ILE C 58 ASP C 60 0 SHEET 2 AB8 3 LEU C 86 GLU C 89 1 O VAL C 88 N LEU C 59 SHEET 3 AB8 3 SER C 266 ARG C 269 1 O MET C 268 N GLU C 89 SHEET 1 AB9 5 PHE C 120 ASN C 122 0 SHEET 2 AB9 5 GLY C 256 LYS C 259 -1 O TYR C 257 N ASN C 121 SHEET 3 AB9 5 LYS C 176 HIS C 184 -1 N LEU C 177 O PHE C 258 SHEET 4 AB9 5 LEU C 251 PRO C 254 -1 O ILE C 252 N GLY C 181 SHEET 5 AB9 5 LEU C 151 TRP C 153 -1 N ASN C 152 O ALA C 253 SHEET 1 AC1 4 PHE C 120 ASN C 122 0 SHEET 2 AC1 4 GLY C 256 LYS C 259 -1 O TYR C 257 N ASN C 121 SHEET 3 AC1 4 LYS C 176 HIS C 184 -1 N LEU C 177 O PHE C 258 SHEET 4 AC1 4 ARG C 229 VAL C 237 -1 O THR C 235 N TYR C 178 SHEET 1 AC2 2 VAL C 130 THR C 131 0 SHEET 2 AC2 2 THR C 155 GLN C 156 -1 O THR C 155 N THR C 131 SHEET 1 AC3 2 SER C 136 ARG C 141 0 SHEET 2 AC3 2 ASN C 144 SER C 146 -1 O SER C 146 N SER C 136 SHEET 1 AC4 4 VAL C 166 PRO C 169 0 SHEET 2 AC4 4 ILE C 242 SER C 247 -1 O ILE C 245 N VAL C 166 SHEET 3 AC4 4 ILE C 202 SER C 205 -1 N SER C 205 O LEU C 244 SHEET 4 AC4 4 GLN C 210 VAL C 213 -1 O VAL C 213 N ILE C 202 SHEET 1 AC5 2 GLY C 303 CYS C 305 0 SHEET 2 AC5 2 ASN D 60 LYS D 62 -1 O LYS D 62 N GLY C 303 SHEET 1 AC6 5 GLY I 31 ASP I 37 0 SHEET 2 AC6 5 TYR I 22 ASN I 28 -1 N TYR I 22 O ASP I 37 SHEET 3 AC6 5 ALA G 11 GLY G 16 -1 N CYS G 14 O ARG I 25 SHEET 4 AC6 5 PHE I 138 ILE I 140 -1 O ILE I 140 N ALA G 11 SHEET 5 AC6 5 ALA I 130 ASP I 132 -1 N GLU I 131 O LYS I 139 SHEET 1 AC7 2 THR G 24 VAL G 26 0 SHEET 2 AC7 2 ILE G 34 VAL G 36 -1 O VAL G 36 N THR G 24 SHEET 1 AC8 2 ALA G 39 GLU G 41 0 SHEET 2 AC8 2 LYS G 315 ALA G 317 -1 O LEU G 316 N THR G 40 SHEET 1 AC9 3 VAL G 43 GLN G 44 0 SHEET 2 AC9 3 PHE G 294 GLN G 295 1 O PHE G 294 N GLN G 44 SHEET 3 AC9 3 ARG G 307 TYR G 308 1 O ARG G 307 N GLN G 295 SHEET 1 AD1 2 ILE G 51 CYS G 52 0 SHEET 2 AD1 2 ILE G 274 GLY G 275 1 O GLY G 275 N ILE G 51 SHEET 1 AD2 3 ILE G 58 ASP G 60 0 SHEET 2 AD2 3 LEU G 86 GLU G 89 1 O LEU G 86 N LEU G 59 SHEET 3 AD2 3 SER G 266 ARG G 269 1 O MET G 268 N GLU G 89 SHEET 1 AD3 2 ASN G 121 ASN G 122 0 SHEET 2 AD3 2 GLY G 256 TYR G 257 -1 O TYR G 257 N ASN G 121 SHEET 1 AD4 2 SER G 136 ILE G 140 0 SHEET 2 AD4 2 ASN G 145 SER G 146 -1 O SER G 146 N CYS G 139 SHEET 1 AD5 4 LEU G 151 TRP G 153 0 SHEET 2 AD5 4 LEU G 251 PRO G 254 -1 O ALA G 253 N ASN G 152 SHEET 3 AD5 4 LYS G 176 HIS G 184 -1 N GLY G 181 O ILE G 252 SHEET 4 AD5 4 ARG G 229 VAL G 237 -1 O THR G 235 N TYR G 178 SHEET 1 AD6 4 LEU G 164 PRO G 169 0 SHEET 2 AD6 4 ILE G 242 SER G 247 -1 O ILE G 245 N VAL G 166 SHEET 3 AD6 4 ILE G 202 SER G 205 -1 N SER G 205 O LEU G 244 SHEET 4 AD6 4 GLN G 210 VAL G 213 -1 O VAL G 213 N ILE G 202 SHEET 1 AD7 2 CYS G 281 ILE G 282 0 SHEET 2 AD7 2 SER G 287 ILE G 288 -1 O ILE G 288 N CYS G 281 SHEET 1 AD8 2 GLY G 303 ALA G 304 0 SHEET 2 AD8 2 GLU I 61 LYS I 62 -1 O LYS I 62 N GLY G 303 SHEET 1 AD9 4 GLN H 3 GLN H 6 0 SHEET 2 AD9 4 VAL H 18 SER H 25 -1 O LYS H 23 N GLN H 5 SHEET 3 AD9 4 THR H 77 LEU H 82 -1 O LEU H 82 N VAL H 18 SHEET 4 AD9 4 LEU H 69 ASP H 72 -1 N THR H 70 O TYR H 79 SHEET 1 AE1 5 TYR H 56 TYR H 59 0 SHEET 2 AE1 5 LEU H 45 ASP H 52 -1 N GLU H 50 O SER H 58 SHEET 3 AE1 5 TRP H 33 GLN H 39 -1 N LYS H 38 O GLU H 46 SHEET 4 AE1 5 VAL H 89 SER H 95 -1 O TYR H 91 N VAL H 37 SHEET 5 AE1 5 PHE H 100B TRP H 103 -1 O TYR H 102 N ARG H 94 SHEET 1 AE2 5 TYR H 56 TYR H 59 0 SHEET 2 AE2 5 LEU H 45 ASP H 52 -1 N GLU H 50 O SER H 58 SHEET 3 AE2 5 TRP H 33 GLN H 39 -1 N LYS H 38 O GLU H 46 SHEET 4 AE2 5 VAL H 89 SER H 95 -1 O TYR H 91 N VAL H 37 SHEET 5 AE2 5 THR H 107 THR H 108 -1 O THR H 107 N TYR H 90 SHEET 1 AE3 4 MET L 4 THR L 5 0 SHEET 2 AE3 4 VAL L 19 ALA L 25 -1 O SER L 24 N THR L 5 SHEET 3 AE3 4 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AE3 4 PHE L 62 SER L 67 -1 N SER L 63 O THR L 74 SHEET 1 AE4 6 SER L 10 SER L 12 0 SHEET 2 AE4 6 THR L 102 GLU L 105 1 O LYS L 103 N LEU L 11 SHEET 3 AE4 6 THR L 85 GLN L 89 -1 N TYR L 86 O THR L 102 SHEET 4 AE4 6 ASN L 34 GLN L 38 -1 N GLN L 38 O THR L 85 SHEET 5 AE4 6 VAL L 44 TYR L 49 -1 O LYS L 45 N GLN L 37 SHEET 6 AE4 6 SER L 53 LEU L 54 -1 O SER L 53 N TYR L 49 SHEET 1 AE5 4 GLN E 3 GLN E 6 0 SHEET 2 AE5 4 VAL E 18 SER E 25 -1 O LYS E 23 N GLN E 5 SHEET 3 AE5 4 THR E 77 LEU E 82 -1 O MET E 80 N LEU E 20 SHEET 4 AE5 4 LEU E 69 ASP E 72 -1 N THR E 70 O TYR E 79 SHEET 1 AE6 5 TYR E 56 TYR E 59 0 SHEET 2 AE6 5 LEU E 45 ASP E 52 -1 N GLU E 50 O SER E 58 SHEET 3 AE6 5 ILE E 34 GLN E 39 -1 N LYS E 38 O GLU E 46 SHEET 4 AE6 5 VAL E 89 ARG E 94 -1 O ALA E 93 N HIS E 35 SHEET 5 AE6 5 TYR E 102 TRP E 103 -1 O TYR E 102 N ARG E 94 SHEET 1 AE7 5 TYR E 56 TYR E 59 0 SHEET 2 AE7 5 LEU E 45 ASP E 52 -1 N GLU E 50 O SER E 58 SHEET 3 AE7 5 ILE E 34 GLN E 39 -1 N LYS E 38 O GLU E 46 SHEET 4 AE7 5 VAL E 89 ARG E 94 -1 O ALA E 93 N HIS E 35 SHEET 5 AE7 5 THR E 107 THR E 108 -1 O THR E 107 N TYR E 90 SHEET 1 AE8 3 MET J 4 GLN J 6 0 SHEET 2 AE8 3 VAL J 19 ILE J 29 -1 O SER J 24 N THR J 5 SHEET 3 AE8 3 PHE J 62 ILE J 75 -1 O TYR J 71 N CYS J 23 SHEET 1 AE9 6 SER J 10 ALA J 13 0 SHEET 2 AE9 6 THR J 102 ILE J 106 1 O GLU J 105 N ALA J 13 SHEET 3 AE9 6 THR J 85 TYR J 87 -1 N TYR J 86 O THR J 102 SHEET 4 AE9 6 TRP J 35 GLN J 38 -1 N GLN J 38 O THR J 85 SHEET 5 AE9 6 VAL J 44 TYR J 49 -1 O LYS J 45 N GLN J 37 SHEET 6 AE9 6 SER J 53 LEU J 54 -1 O SER J 53 N TYR J 49 SHEET 1 AF1 4 GLN F 3 GLN F 6 0 SHEET 2 AF1 4 VAL F 18 SER F 25 -1 O SER F 25 N GLN F 3 SHEET 3 AF1 4 THR F 77 LEU F 82 -1 O LEU F 82 N VAL F 18 SHEET 4 AF1 4 ALA F 67 ASP F 72 -1 N THR F 70 O TYR F 79 SHEET 1 AF2 5 TYR F 56 TYR F 59 0 SHEET 2 AF2 5 LEU F 45 ASP F 52 -1 N GLU F 50 O SER F 58 SHEET 3 AF2 5 ILE F 34 GLN F 39 -1 N TRP F 36 O ILE F 48 SHEET 4 AF2 5 VAL F 89 ARG F 94 -1 O TYR F 91 N VAL F 37 SHEET 5 AF2 5 TYR F 102 TRP F 103 -1 O TYR F 102 N ARG F 94 SHEET 1 AF3 5 TYR F 56 TYR F 59 0 SHEET 2 AF3 5 LEU F 45 ASP F 52 -1 N GLU F 50 O SER F 58 SHEET 3 AF3 5 ILE F 34 GLN F 39 -1 N TRP F 36 O ILE F 48 SHEET 4 AF3 5 VAL F 89 ARG F 94 -1 O TYR F 91 N VAL F 37 SHEET 5 AF3 5 THR F 107 THR F 108 -1 O THR F 107 N TYR F 90 SHEET 1 AF4 5 SER K 10 SER K 12 0 SHEET 2 AF4 5 THR K 102 GLU K 105 1 O LYS K 103 N LEU K 11 SHEET 3 AF4 5 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AF4 5 LEU K 33 GLN K 38 -1 N ASN K 34 O GLN K 89 SHEET 5 AF4 5 VAL K 44 ILE K 48 -1 O LYS K 45 N GLN K 37 SHEET 1 AF5 3 VAL K 19 SER K 24 0 SHEET 2 AF5 3 ASP K 70 ILE K 75 -1 O LEU K 73 N ILE K 21 SHEET 3 AF5 3 PHE K 62 SER K 67 -1 N SER K 63 O THR K 74 SSBOND 1 CYS A 14 CYS B 137 1555 1555 2.39 SSBOND 2 CYS A 30 CYS I 47 1555 1555 2.03 SSBOND 3 CYS A 52 CYS A 277 1555 1555 2.03 SSBOND 4 CYS A 64 CYS A 76 1555 1555 2.03 SSBOND 5 CYS A 97 CYS A 139 1555 1555 2.03 SSBOND 6 CYS A 281 CYS A 305 1555 1555 2.03 SSBOND 7 CYS B 144 CYS B 148 1555 1555 2.03 SSBOND 8 CYS C 14 CYS D 137 1555 1555 2.03 SSBOND 9 CYS C 52 CYS C 277 1555 1555 2.03 SSBOND 10 CYS C 64 CYS C 76 1555 1555 2.03 SSBOND 11 CYS C 97 CYS C 139 1555 1555 2.03 SSBOND 12 CYS C 281 CYS C 305 1555 1555 2.03 SSBOND 13 CYS D 47 CYS G 30 1555 1555 2.04 SSBOND 14 CYS D 144 CYS D 148 1555 1555 2.03 SSBOND 15 CYS G 14 CYS I 137 1555 1555 2.03 SSBOND 16 CYS G 52 CYS G 277 1555 1555 2.02 SSBOND 17 CYS G 64 CYS G 76 1555 1555 2.03 SSBOND 18 CYS G 97 CYS G 139 1555 1555 2.03 SSBOND 19 CYS G 281 CYS G 305 1555 1555 2.03 SSBOND 20 CYS I 144 CYS I 148 1555 1555 2.03 SSBOND 21 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 22 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 23 CYS E 22 CYS E 92 1555 1555 2.03 SSBOND 24 CYS J 23 CYS J 88 1555 1555 2.03 SSBOND 25 CYS F 22 CYS F 92 1555 1555 2.03 SSBOND 26 CYS K 23 CYS K 88 1555 1555 2.03 LINK ND2 ASN A 63 C1 NAG A 402 1555 1555 1.44 LINK ND2 ASN A 126 C1 NAG A 403 1555 1555 1.44 LINK ND2 ASN A 133 C1 NAG A 404 1555 1555 1.44 LINK ND2 ASN B 154 C1 NAG B 301 1555 1555 1.44 LINK ND2 ASN C 22 C1 NAG C 401 1555 1555 1.45 LINK ND2 ASN C 63 C1 NAG C 402 1555 1555 1.44 LINK ND2 ASN C 126 C1 NAG C 403 1555 1555 1.44 LINK ND2 ASN C 133 C1 NAG C 404 1555 1555 1.44 LINK ND2 ASN C 165 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN C 246 C1 NAG S 1 1555 1555 1.45 LINK ND2 ASN C 285 C1 NAG T 1 1555 1555 1.45 LINK ND2 ASN D 154 C1 NAG D 301 1555 1555 1.46 LINK ND2 ASN G 22 C1 NAG G 401 1555 1555 1.44 LINK ND2 ASN G 63 C1 NAG G 402 1555 1555 1.44 LINK ND2 ASN G 126 C1 NAG G 403 1555 1555 1.44 LINK ND2 ASN G 133 C1 NAG G 404 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.45 LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.44 LINK O3 BMA M 3 C1 MAN M 4 1555 1555 1.46 LINK O6 BMA M 3 C1 MAN M 5 1555 1555 1.45 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG N 2 C1 BMA N 3 1555 1555 1.45 LINK O3 BMA N 3 C1 MAN N 4 1555 1555 1.44 LINK O6 BMA N 3 C1 MAN N 5 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.44 LINK O3 BMA O 3 C1 MAN O 4 1555 1555 1.44 LINK O6 BMA O 3 C1 MAN O 5 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.45 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.45 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG Q 2 C1 BMA Q 3 1555 1555 1.45 LINK O3 BMA Q 3 C1 MAN Q 4 1555 1555 1.44 LINK O6 BMA Q 3 C1 MAN Q 5 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG R 2 C1 BMA R 3 1555 1555 1.44 LINK O3 BMA R 3 C1 MAN R 4 1555 1555 1.44 LINK O6 BMA R 3 C1 MAN R 5 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG S 2 C1 BMA S 3 1555 1555 1.44 LINK O3 BMA S 3 C1 MAN S 4 1555 1555 1.44 LINK O6 BMA S 3 C1 MAN S 5 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.45 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.45 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.45 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.44 LINK O6 BMA U 3 C1 MAN U 5 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG V 2 C1 BMA V 3 1555 1555 1.45 LINK O3 BMA V 3 C1 MAN V 4 1555 1555 1.44 LINK O6 BMA V 3 C1 MAN V 5 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG W 2 C1 BMA W 3 1555 1555 1.44 LINK O3 BMA W 3 C1 MAN W 4 1555 1555 1.44 LINK O6 BMA W 3 C1 MAN W 5 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.45 LINK O4 NAG X 2 C1 BMA X 3 1555 1555 1.45 CISPEP 1 LEU L 94 PRO L 95 0 -15.31 CISPEP 2 LEU J 94 PRO J 95 0 -26.82 CISPEP 3 LEU K 94 PRO K 95 0 2.19 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000