HEADER VIRAL PROTEIN 17-OCT-23 8UME TITLE INFLUENZA A VIRUS HEMAGGLUTININ H5/VIETNAM/1204/2004 IN COMPLEX WITH TITLE 2 D04 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: B, C, A; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: FAB HEAVY CHAIN; COMPND 7 CHAIN: H, D, E; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: FAB LIGHT CHAIN; COMPND 11 CHAIN: L, F, G; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 11320; SOURCE 4 GENE: HA; SOURCE 5 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS HEMAGGLUTININ, INFLUENZA A, ANTIBODY, FAB, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR A.S.FERREIRA RAMOS,G.BAJIC REVDAT 1 25-DEC-24 8UME 0 JRNL AUTH J.FELDMAN,M.VU,A.S.FERREIRA RAMOS,D.MAURER,G.BAJIC,G.S.AARON JRNL TITL AVIAN INFLUENZA-SPECIFIC NAIVE B CELLS ENGAGE HA SITES OF JRNL TITL 2 VULNERABILITY JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.10 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.100 REMARK 3 NUMBER OF PARTICLES : 77276 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING ONLY REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8UME COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-OCT-23. REMARK 100 THE DEPOSITION ID IS D_1000278382. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HA/FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : OTHER REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5849.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, H, L, D, F, E, G, C, A REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ASP B 11 REMARK 465 GLN B 12 REMARK 465 ILE B 13 REMARK 465 CYS B 14 REMARK 465 SER B 322A REMARK 465 PRO B 322B REMARK 465 GLN B 322C REMARK 465 ARG B 322D REMARK 465 GLU B 322E REMARK 465 ARG B 322F REMARK 465 GLY B 322G REMARK 465 LEU B 322H REMARK 465 PHE B 322I REMARK 465 TYR B 342A REMARK 465 HIS B 342B REMARK 465 HIS B 342C REMARK 465 SER B 342D REMARK 465 ASN B 342E REMARK 465 GLU B 342F REMARK 465 GLN B 342G REMARK 465 GLY B 342H REMARK 465 SER B 342I REMARK 465 GLY B 342J REMARK 465 TYR B 342K REMARK 465 ALA B 342L REMARK 465 LEU B 439A REMARK 465 GLY B 439B REMARK 465 ASN B 439C REMARK 465 GLY B 439D REMARK 465 CYS B 439E REMARK 465 PHE B 439F REMARK 465 GLU B 439G REMARK 465 PHE B 439H REMARK 465 TYR B 439I REMARK 465 VAL B 474 REMARK 465 ARG B 475 REMARK 465 SER B 476 REMARK 465 GLY B 477 REMARK 465 ALA B 478 REMARK 465 GLY B 479 REMARK 465 SER B 480 REMARK 465 SER B 481 REMARK 465 GLY B 482 REMARK 465 SER B 483 REMARK 465 GLY B 484 REMARK 465 ARG B 485 REMARK 465 MET B 486 REMARK 465 LYS B 487 REMARK 465 GLN B 488 REMARK 465 ILE B 489 REMARK 465 GLU B 490 REMARK 465 ASP B 491 REMARK 465 LYS B 492 REMARK 465 ILE B 493 REMARK 465 GLU B 494 REMARK 465 GLU B 495 REMARK 465 ILE B 496 REMARK 465 LEU B 497 REMARK 465 SER B 498 REMARK 465 LYS B 499 REMARK 465 ILE B 500 REMARK 465 TYR B 501 REMARK 465 HIS B 502 REMARK 465 ILE B 503 REMARK 465 GLU B 504 REMARK 465 ASN B 505 REMARK 465 GLU B 506 REMARK 465 ILE B 507 REMARK 465 ALA B 508 REMARK 465 ARG B 509 REMARK 465 ILE B 510 REMARK 465 LYS B 511 REMARK 465 LYS B 512 REMARK 465 LEU B 513 REMARK 465 ILE B 514 REMARK 465 GLY B 515 REMARK 465 GLU B 516 REMARK 465 ARG B 517 REMARK 465 SER B 518 REMARK 465 GLY B 519 REMARK 465 GLY B 520 REMARK 465 ALA H 121 REMARK 465 SER H 122 REMARK 465 THR H 123 REMARK 465 LYS H 124 REMARK 465 GLY H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 VAL H 128 REMARK 465 PHE H 129 REMARK 465 PRO H 130 REMARK 465 LEU H 131 REMARK 465 ALA H 132 REMARK 465 PRO H 133 REMARK 465 SER H 134 REMARK 465 SER H 135 REMARK 465 LYS H 136 REMARK 465 SER H 137 REMARK 465 THR H 138 REMARK 465 SER H 139 REMARK 465 GLY H 140 REMARK 465 GLY H 141 REMARK 465 THR H 142 REMARK 465 ALA H 143 REMARK 465 ALA H 144 REMARK 465 LEU H 145 REMARK 465 GLY H 146 REMARK 465 CYS H 147 REMARK 465 LEU H 148 REMARK 465 VAL H 149 REMARK 465 LYS H 150 REMARK 465 ASP H 151 REMARK 465 TYR H 152 REMARK 465 PHE H 153 REMARK 465 PRO H 154 REMARK 465 GLU H 155 REMARK 465 PRO H 156 REMARK 465 VAL H 157 REMARK 465 THR H 158 REMARK 465 VAL H 159 REMARK 465 SER H 160 REMARK 465 TRP H 161 REMARK 465 ASN H 162 REMARK 465 SER H 163 REMARK 465 GLY H 164 REMARK 465 ALA H 165 REMARK 465 LEU H 166 REMARK 465 THR H 167 REMARK 465 SER H 168 REMARK 465 GLY H 169 REMARK 465 VAL H 170 REMARK 465 HIS H 171 REMARK 465 THR H 172 REMARK 465 PHE H 173 REMARK 465 PRO H 174 REMARK 465 ALA H 175 REMARK 465 VAL H 176 REMARK 465 LEU H 177 REMARK 465 GLN H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 GLY H 181 REMARK 465 LEU H 182 REMARK 465 TYR H 183 REMARK 465 SER H 184 REMARK 465 LEU H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 VAL H 188 REMARK 465 VAL H 189 REMARK 465 THR H 190 REMARK 465 VAL H 191 REMARK 465 PRO H 192 REMARK 465 SER H 193 REMARK 465 SER H 194 REMARK 465 SER H 195 REMARK 465 LEU H 196 REMARK 465 GLY H 197 REMARK 465 THR H 198 REMARK 465 GLN H 199 REMARK 465 THR H 200 REMARK 465 TYR H 201 REMARK 465 ILE H 202 REMARK 465 CYS H 203 REMARK 465 ASN H 204 REMARK 465 VAL H 205 REMARK 465 ASN H 206 REMARK 465 HIS H 207 REMARK 465 LYS H 208 REMARK 465 PRO H 209 REMARK 465 SER H 210 REMARK 465 ASN H 211 REMARK 465 THR H 212 REMARK 465 LYS H 213 REMARK 465 VAL H 214 REMARK 465 ASP H 215 REMARK 465 LYS H 216 REMARK 465 ARG H 217 REMARK 465 VAL H 218 REMARK 465 GLU H 219 REMARK 465 PRO H 220 REMARK 465 LYS H 221 REMARK 465 SER H 222 REMARK 465 CYS H 223 REMARK 465 ASP H 224 REMARK 465 LYS H 225 REMARK 465 GLY H 226 REMARK 465 SER H 227 REMARK 465 SER H 228 REMARK 465 ARG L 115 REMARK 465 THR L 116 REMARK 465 VAL L 117 REMARK 465 ALA L 118 REMARK 465 ALA L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 VAL L 122 REMARK 465 PHE L 123 REMARK 465 ILE L 124 REMARK 465 PHE L 125 REMARK 465 PRO L 126 REMARK 465 PRO L 127 REMARK 465 SER L 128 REMARK 465 ASP L 129 REMARK 465 GLU L 130 REMARK 465 GLN L 131 REMARK 465 LEU L 132 REMARK 465 LYS L 133 REMARK 465 SER L 134 REMARK 465 GLY L 135 REMARK 465 THR L 136 REMARK 465 ALA L 137 REMARK 465 SER L 138 REMARK 465 VAL L 139 REMARK 465 VAL L 140 REMARK 465 CYS L 141 REMARK 465 LEU L 142 REMARK 465 LEU L 143 REMARK 465 ASN L 144 REMARK 465 ASN L 145 REMARK 465 PHE L 146 REMARK 465 TYR L 147 REMARK 465 PRO L 148 REMARK 465 ARG L 149 REMARK 465 GLU L 150 REMARK 465 ALA L 151 REMARK 465 LYS L 152 REMARK 465 VAL L 153 REMARK 465 GLN L 154 REMARK 465 TRP L 155 REMARK 465 LYS L 156 REMARK 465 VAL L 157 REMARK 465 ASP L 158 REMARK 465 ASN L 159 REMARK 465 ALA L 160 REMARK 465 LEU L 161 REMARK 465 GLN L 162 REMARK 465 SER L 163 REMARK 465 GLY L 164 REMARK 465 ASN L 165 REMARK 465 SER L 166 REMARK 465 GLN L 167 REMARK 465 GLU L 168 REMARK 465 SER L 169 REMARK 465 VAL L 170 REMARK 465 THR L 171 REMARK 465 GLU L 172 REMARK 465 GLN L 173 REMARK 465 ASP L 174 REMARK 465 SER L 175 REMARK 465 LYS L 176 REMARK 465 ASP L 177 REMARK 465 SER L 178 REMARK 465 THR L 179 REMARK 465 TYR L 180 REMARK 465 SER L 181 REMARK 465 LEU L 182 REMARK 465 SER L 183 REMARK 465 SER L 184 REMARK 465 THR L 185 REMARK 465 LEU L 186 REMARK 465 THR L 187 REMARK 465 LEU L 188 REMARK 465 SER L 189 REMARK 465 LYS L 190 REMARK 465 ALA L 191 REMARK 465 ASP L 192 REMARK 465 TYR L 193 REMARK 465 GLU L 194 REMARK 465 LYS L 195 REMARK 465 HIS L 196 REMARK 465 LYS L 197 REMARK 465 VAL L 198 REMARK 465 TYR L 199 REMARK 465 ALA L 200 REMARK 465 CYS L 201 REMARK 465 GLU L 202 REMARK 465 VAL L 203 REMARK 465 THR L 204 REMARK 465 HIS L 205 REMARK 465 GLN L 206 REMARK 465 GLY L 207 REMARK 465 LEU L 208 REMARK 465 SER L 209 REMARK 465 SER L 210 REMARK 465 PRO L 211 REMARK 465 VAL L 212 REMARK 465 THR L 213 REMARK 465 LYS L 214 REMARK 465 SER L 215 REMARK 465 PHE L 216 REMARK 465 ASN L 217 REMARK 465 ARG L 218 REMARK 465 GLY L 219 REMARK 465 GLU L 220 REMARK 465 CYS L 221 REMARK 465 ALA D 121 REMARK 465 SER D 122 REMARK 465 THR D 123 REMARK 465 LYS D 124 REMARK 465 GLY D 125 REMARK 465 PRO D 126 REMARK 465 SER D 127 REMARK 465 VAL D 128 REMARK 465 PHE D 129 REMARK 465 PRO D 130 REMARK 465 LEU D 131 REMARK 465 ALA D 132 REMARK 465 PRO D 133 REMARK 465 SER D 134 REMARK 465 SER D 135 REMARK 465 LYS D 136 REMARK 465 SER D 137 REMARK 465 THR D 138 REMARK 465 SER D 139 REMARK 465 GLY D 140 REMARK 465 GLY D 141 REMARK 465 THR D 142 REMARK 465 ALA D 143 REMARK 465 ALA D 144 REMARK 465 LEU D 145 REMARK 465 GLY D 146 REMARK 465 CYS D 147 REMARK 465 LEU D 148 REMARK 465 VAL D 149 REMARK 465 LYS D 150 REMARK 465 ASP D 151 REMARK 465 TYR D 152 REMARK 465 PHE D 153 REMARK 465 PRO D 154 REMARK 465 GLU D 155 REMARK 465 PRO D 156 REMARK 465 VAL D 157 REMARK 465 THR D 158 REMARK 465 VAL D 159 REMARK 465 SER D 160 REMARK 465 TRP D 161 REMARK 465 ASN D 162 REMARK 465 SER D 163 REMARK 465 GLY D 164 REMARK 465 ALA D 165 REMARK 465 LEU D 166 REMARK 465 THR D 167 REMARK 465 SER D 168 REMARK 465 GLY D 169 REMARK 465 VAL D 170 REMARK 465 HIS D 171 REMARK 465 THR D 172 REMARK 465 PHE D 173 REMARK 465 PRO D 174 REMARK 465 ALA D 175 REMARK 465 VAL D 176 REMARK 465 LEU D 177 REMARK 465 GLN D 178 REMARK 465 SER D 179 REMARK 465 SER D 180 REMARK 465 GLY D 181 REMARK 465 LEU D 182 REMARK 465 TYR D 183 REMARK 465 SER D 184 REMARK 465 LEU D 185 REMARK 465 SER D 186 REMARK 465 SER D 187 REMARK 465 VAL D 188 REMARK 465 VAL D 189 REMARK 465 THR D 190 REMARK 465 VAL D 191 REMARK 465 PRO D 192 REMARK 465 SER D 193 REMARK 465 SER D 194 REMARK 465 SER D 195 REMARK 465 LEU D 196 REMARK 465 GLY D 197 REMARK 465 THR D 198 REMARK 465 GLN D 199 REMARK 465 THR D 200 REMARK 465 TYR D 201 REMARK 465 ILE D 202 REMARK 465 CYS D 203 REMARK 465 ASN D 204 REMARK 465 VAL D 205 REMARK 465 ASN D 206 REMARK 465 HIS D 207 REMARK 465 LYS D 208 REMARK 465 PRO D 209 REMARK 465 SER D 210 REMARK 465 ASN D 211 REMARK 465 THR D 212 REMARK 465 LYS D 213 REMARK 465 VAL D 214 REMARK 465 ASP D 215 REMARK 465 LYS D 216 REMARK 465 ARG D 217 REMARK 465 VAL D 218 REMARK 465 GLU D 219 REMARK 465 PRO D 220 REMARK 465 LYS D 221 REMARK 465 SER D 222 REMARK 465 CYS D 223 REMARK 465 ASP D 224 REMARK 465 LYS D 225 REMARK 465 GLY D 226 REMARK 465 SER D 227 REMARK 465 SER D 228 REMARK 465 ARG F 115 REMARK 465 THR F 116 REMARK 465 VAL F 117 REMARK 465 ALA F 118 REMARK 465 ALA F 119 REMARK 465 PRO F 120 REMARK 465 SER F 121 REMARK 465 VAL F 122 REMARK 465 PHE F 123 REMARK 465 ILE F 124 REMARK 465 PHE F 125 REMARK 465 PRO F 126 REMARK 465 PRO F 127 REMARK 465 SER F 128 REMARK 465 ASP F 129 REMARK 465 GLU F 130 REMARK 465 GLN F 131 REMARK 465 LEU F 132 REMARK 465 LYS F 133 REMARK 465 SER F 134 REMARK 465 GLY F 135 REMARK 465 THR F 136 REMARK 465 ALA F 137 REMARK 465 SER F 138 REMARK 465 VAL F 139 REMARK 465 VAL F 140 REMARK 465 CYS F 141 REMARK 465 LEU F 142 REMARK 465 LEU F 143 REMARK 465 ASN F 144 REMARK 465 ASN F 145 REMARK 465 PHE F 146 REMARK 465 TYR F 147 REMARK 465 PRO F 148 REMARK 465 ARG F 149 REMARK 465 GLU F 150 REMARK 465 ALA F 151 REMARK 465 LYS F 152 REMARK 465 VAL F 153 REMARK 465 GLN F 154 REMARK 465 TRP F 155 REMARK 465 LYS F 156 REMARK 465 VAL F 157 REMARK 465 ASP F 158 REMARK 465 ASN F 159 REMARK 465 ALA F 160 REMARK 465 LEU F 161 REMARK 465 GLN F 162 REMARK 465 SER F 163 REMARK 465 GLY F 164 REMARK 465 ASN F 165 REMARK 465 SER F 166 REMARK 465 GLN F 167 REMARK 465 GLU F 168 REMARK 465 SER F 169 REMARK 465 VAL F 170 REMARK 465 THR F 171 REMARK 465 GLU F 172 REMARK 465 GLN F 173 REMARK 465 ASP F 174 REMARK 465 SER F 175 REMARK 465 LYS F 176 REMARK 465 ASP F 177 REMARK 465 SER F 178 REMARK 465 THR F 179 REMARK 465 TYR F 180 REMARK 465 SER F 181 REMARK 465 LEU F 182 REMARK 465 SER F 183 REMARK 465 SER F 184 REMARK 465 THR F 185 REMARK 465 LEU F 186 REMARK 465 THR F 187 REMARK 465 LEU F 188 REMARK 465 SER F 189 REMARK 465 LYS F 190 REMARK 465 ALA F 191 REMARK 465 ASP F 192 REMARK 465 TYR F 193 REMARK 465 GLU F 194 REMARK 465 LYS F 195 REMARK 465 HIS F 196 REMARK 465 LYS F 197 REMARK 465 VAL F 198 REMARK 465 TYR F 199 REMARK 465 ALA F 200 REMARK 465 CYS F 201 REMARK 465 GLU F 202 REMARK 465 VAL F 203 REMARK 465 THR F 204 REMARK 465 HIS F 205 REMARK 465 GLN F 206 REMARK 465 GLY F 207 REMARK 465 LEU F 208 REMARK 465 SER F 209 REMARK 465 SER F 210 REMARK 465 PRO F 211 REMARK 465 VAL F 212 REMARK 465 THR F 213 REMARK 465 LYS F 214 REMARK 465 SER F 215 REMARK 465 PHE F 216 REMARK 465 ASN F 217 REMARK 465 ARG F 218 REMARK 465 GLY F 219 REMARK 465 GLU F 220 REMARK 465 CYS F 221 REMARK 465 ALA E 121 REMARK 465 SER E 122 REMARK 465 THR E 123 REMARK 465 LYS E 124 REMARK 465 GLY E 125 REMARK 465 PRO E 126 REMARK 465 SER E 127 REMARK 465 VAL E 128 REMARK 465 PHE E 129 REMARK 465 PRO E 130 REMARK 465 LEU E 131 REMARK 465 ALA E 132 REMARK 465 PRO E 133 REMARK 465 SER E 134 REMARK 465 SER E 135 REMARK 465 LYS E 136 REMARK 465 SER E 137 REMARK 465 THR E 138 REMARK 465 SER E 139 REMARK 465 GLY E 140 REMARK 465 GLY E 141 REMARK 465 THR E 142 REMARK 465 ALA E 143 REMARK 465 ALA E 144 REMARK 465 LEU E 145 REMARK 465 GLY E 146 REMARK 465 CYS E 147 REMARK 465 LEU E 148 REMARK 465 VAL E 149 REMARK 465 LYS E 150 REMARK 465 ASP E 151 REMARK 465 TYR E 152 REMARK 465 PHE E 153 REMARK 465 PRO E 154 REMARK 465 GLU E 155 REMARK 465 PRO E 156 REMARK 465 VAL E 157 REMARK 465 THR E 158 REMARK 465 VAL E 159 REMARK 465 SER E 160 REMARK 465 TRP E 161 REMARK 465 ASN E 162 REMARK 465 SER E 163 REMARK 465 GLY E 164 REMARK 465 ALA E 165 REMARK 465 LEU E 166 REMARK 465 THR E 167 REMARK 465 SER E 168 REMARK 465 GLY E 169 REMARK 465 VAL E 170 REMARK 465 HIS E 171 REMARK 465 THR E 172 REMARK 465 PHE E 173 REMARK 465 PRO E 174 REMARK 465 ALA E 175 REMARK 465 VAL E 176 REMARK 465 LEU E 177 REMARK 465 GLN E 178 REMARK 465 SER E 179 REMARK 465 SER E 180 REMARK 465 GLY E 181 REMARK 465 LEU E 182 REMARK 465 TYR E 183 REMARK 465 SER E 184 REMARK 465 LEU E 185 REMARK 465 SER E 186 REMARK 465 SER E 187 REMARK 465 VAL E 188 REMARK 465 VAL E 189 REMARK 465 THR E 190 REMARK 465 VAL E 191 REMARK 465 PRO E 192 REMARK 465 SER E 193 REMARK 465 SER E 194 REMARK 465 SER E 195 REMARK 465 LEU E 196 REMARK 465 GLY E 197 REMARK 465 THR E 198 REMARK 465 GLN E 199 REMARK 465 THR E 200 REMARK 465 TYR E 201 REMARK 465 ILE E 202 REMARK 465 CYS E 203 REMARK 465 ASN E 204 REMARK 465 VAL E 205 REMARK 465 ASN E 206 REMARK 465 HIS E 207 REMARK 465 LYS E 208 REMARK 465 PRO E 209 REMARK 465 SER E 210 REMARK 465 ASN E 211 REMARK 465 THR E 212 REMARK 465 LYS E 213 REMARK 465 VAL E 214 REMARK 465 ASP E 215 REMARK 465 LYS E 216 REMARK 465 ARG E 217 REMARK 465 VAL E 218 REMARK 465 GLU E 219 REMARK 465 PRO E 220 REMARK 465 LYS E 221 REMARK 465 SER E 222 REMARK 465 CYS E 223 REMARK 465 ASP E 224 REMARK 465 LYS E 225 REMARK 465 GLY E 226 REMARK 465 SER E 227 REMARK 465 SER E 228 REMARK 465 ARG G 115 REMARK 465 THR G 116 REMARK 465 VAL G 117 REMARK 465 ALA G 118 REMARK 465 ALA G 119 REMARK 465 PRO G 120 REMARK 465 SER G 121 REMARK 465 VAL G 122 REMARK 465 PHE G 123 REMARK 465 ILE G 124 REMARK 465 PHE G 125 REMARK 465 PRO G 126 REMARK 465 PRO G 127 REMARK 465 SER G 128 REMARK 465 ASP G 129 REMARK 465 GLU G 130 REMARK 465 GLN G 131 REMARK 465 LEU G 132 REMARK 465 LYS G 133 REMARK 465 SER G 134 REMARK 465 GLY G 135 REMARK 465 THR G 136 REMARK 465 ALA G 137 REMARK 465 SER G 138 REMARK 465 VAL G 139 REMARK 465 VAL G 140 REMARK 465 CYS G 141 REMARK 465 LEU G 142 REMARK 465 LEU G 143 REMARK 465 ASN G 144 REMARK 465 ASN G 145 REMARK 465 PHE G 146 REMARK 465 TYR G 147 REMARK 465 PRO G 148 REMARK 465 ARG G 149 REMARK 465 GLU G 150 REMARK 465 ALA G 151 REMARK 465 LYS G 152 REMARK 465 VAL G 153 REMARK 465 GLN G 154 REMARK 465 TRP G 155 REMARK 465 LYS G 156 REMARK 465 VAL G 157 REMARK 465 ASP G 158 REMARK 465 ASN G 159 REMARK 465 ALA G 160 REMARK 465 LEU G 161 REMARK 465 GLN G 162 REMARK 465 SER G 163 REMARK 465 GLY G 164 REMARK 465 ASN G 165 REMARK 465 SER G 166 REMARK 465 GLN G 167 REMARK 465 GLU G 168 REMARK 465 SER G 169 REMARK 465 VAL G 170 REMARK 465 THR G 171 REMARK 465 GLU G 172 REMARK 465 GLN G 173 REMARK 465 ASP G 174 REMARK 465 SER G 175 REMARK 465 LYS G 176 REMARK 465 ASP G 177 REMARK 465 SER G 178 REMARK 465 THR G 179 REMARK 465 TYR G 180 REMARK 465 SER G 181 REMARK 465 LEU G 182 REMARK 465 SER G 183 REMARK 465 SER G 184 REMARK 465 THR G 185 REMARK 465 LEU G 186 REMARK 465 THR G 187 REMARK 465 LEU G 188 REMARK 465 SER G 189 REMARK 465 LYS G 190 REMARK 465 ALA G 191 REMARK 465 ASP G 192 REMARK 465 TYR G 193 REMARK 465 GLU G 194 REMARK 465 LYS G 195 REMARK 465 HIS G 196 REMARK 465 LYS G 197 REMARK 465 VAL G 198 REMARK 465 TYR G 199 REMARK 465 ALA G 200 REMARK 465 CYS G 201 REMARK 465 GLU G 202 REMARK 465 VAL G 203 REMARK 465 THR G 204 REMARK 465 HIS G 205 REMARK 465 GLN G 206 REMARK 465 GLY G 207 REMARK 465 LEU G 208 REMARK 465 SER G 209 REMARK 465 SER G 210 REMARK 465 PRO G 211 REMARK 465 VAL G 212 REMARK 465 THR G 213 REMARK 465 LYS G 214 REMARK 465 SER G 215 REMARK 465 PHE G 216 REMARK 465 ASN G 217 REMARK 465 ARG G 218 REMARK 465 GLY G 219 REMARK 465 GLU G 220 REMARK 465 CYS G 221 REMARK 465 ASP C 11 REMARK 465 GLN C 12 REMARK 465 ILE C 13 REMARK 465 CYS C 14 REMARK 465 SER C 322A REMARK 465 PRO C 322B REMARK 465 GLN C 322C REMARK 465 ARG C 322D REMARK 465 GLU C 322E REMARK 465 ARG C 322F REMARK 465 GLY C 322G REMARK 465 LEU C 322H REMARK 465 PHE C 322I REMARK 465 TYR C 342A REMARK 465 HIS C 342B REMARK 465 HIS C 342C REMARK 465 SER C 342D REMARK 465 ASN C 342E REMARK 465 GLU C 342F REMARK 465 GLN C 342G REMARK 465 GLY C 342H REMARK 465 SER C 342I REMARK 465 GLY C 342J REMARK 465 TYR C 342K REMARK 465 ALA C 342L REMARK 465 LEU C 439A REMARK 465 GLY C 439B REMARK 465 ASN C 439C REMARK 465 GLY C 439D REMARK 465 CYS C 439E REMARK 465 PHE C 439F REMARK 465 GLU C 439G REMARK 465 PHE C 439H REMARK 465 TYR C 439I REMARK 465 VAL C 474 REMARK 465 ARG C 475 REMARK 465 SER C 476 REMARK 465 GLY C 477 REMARK 465 ALA C 478 REMARK 465 GLY C 479 REMARK 465 SER C 480 REMARK 465 SER C 481 REMARK 465 GLY C 482 REMARK 465 SER C 483 REMARK 465 GLY C 484 REMARK 465 ARG C 485 REMARK 465 MET C 486 REMARK 465 LYS C 487 REMARK 465 GLN C 488 REMARK 465 ILE C 489 REMARK 465 GLU C 490 REMARK 465 ASP C 491 REMARK 465 LYS C 492 REMARK 465 ILE C 493 REMARK 465 GLU C 494 REMARK 465 GLU C 495 REMARK 465 ILE C 496 REMARK 465 LEU C 497 REMARK 465 SER C 498 REMARK 465 LYS C 499 REMARK 465 ILE C 500 REMARK 465 TYR C 501 REMARK 465 HIS C 502 REMARK 465 ILE C 503 REMARK 465 GLU C 504 REMARK 465 ASN C 505 REMARK 465 GLU C 506 REMARK 465 ILE C 507 REMARK 465 ALA C 508 REMARK 465 ARG C 509 REMARK 465 ILE C 510 REMARK 465 LYS C 511 REMARK 465 LYS C 512 REMARK 465 LEU C 513 REMARK 465 ILE C 514 REMARK 465 GLY C 515 REMARK 465 GLU C 516 REMARK 465 ARG C 517 REMARK 465 SER C 518 REMARK 465 GLY C 519 REMARK 465 GLY C 520 REMARK 465 ASP A 11 REMARK 465 GLN A 12 REMARK 465 ILE A 13 REMARK 465 CYS A 14 REMARK 465 SER A 322A REMARK 465 PRO A 322B REMARK 465 GLN A 322C REMARK 465 ARG A 322D REMARK 465 GLU A 322E REMARK 465 ARG A 322F REMARK 465 GLY A 322G REMARK 465 LEU A 322H REMARK 465 PHE A 322I REMARK 465 TYR A 342A REMARK 465 HIS A 342B REMARK 465 HIS A 342C REMARK 465 SER A 342D REMARK 465 ASN A 342E REMARK 465 GLU A 342F REMARK 465 GLN A 342G REMARK 465 GLY A 342H REMARK 465 SER A 342I REMARK 465 GLY A 342J REMARK 465 TYR A 342K REMARK 465 ALA A 342L REMARK 465 LEU A 439A REMARK 465 GLY A 439B REMARK 465 ASN A 439C REMARK 465 GLY A 439D REMARK 465 CYS A 439E REMARK 465 PHE A 439F REMARK 465 GLU A 439G REMARK 465 PHE A 439H REMARK 465 TYR A 439I REMARK 465 VAL A 474 REMARK 465 ARG A 475 REMARK 465 SER A 476 REMARK 465 GLY A 477 REMARK 465 ALA A 478 REMARK 465 GLY A 479 REMARK 465 SER A 480 REMARK 465 SER A 481 REMARK 465 GLY A 482 REMARK 465 SER A 483 REMARK 465 GLY A 484 REMARK 465 ARG A 485 REMARK 465 MET A 486 REMARK 465 LYS A 487 REMARK 465 GLN A 488 REMARK 465 ILE A 489 REMARK 465 GLU A 490 REMARK 465 ASP A 491 REMARK 465 LYS A 492 REMARK 465 ILE A 493 REMARK 465 GLU A 494 REMARK 465 GLU A 495 REMARK 465 ILE A 496 REMARK 465 LEU A 497 REMARK 465 SER A 498 REMARK 465 LYS A 499 REMARK 465 ILE A 500 REMARK 465 TYR A 501 REMARK 465 HIS A 502 REMARK 465 ILE A 503 REMARK 465 GLU A 504 REMARK 465 ASN A 505 REMARK 465 GLU A 506 REMARK 465 ILE A 507 REMARK 465 ALA A 508 REMARK 465 ARG A 509 REMARK 465 ILE A 510 REMARK 465 LYS A 511 REMARK 465 LYS A 512 REMARK 465 LEU A 513 REMARK 465 ILE A 514 REMARK 465 GLY A 515 REMARK 465 GLU A 516 REMARK 465 ARG A 517 REMARK 465 SER A 518 REMARK 465 GLY A 519 REMARK 465 GLY A 520 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 ND2 ASN B 150 OH TYR B 258 1.98 REMARK 500 OE2 GLU A 44 OG SER A 290 2.08 REMARK 500 O TYR G 55 OG1 THR G 59 2.10 REMARK 500 O HIS A 38 OG1 THR A 318 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS B 277 CA - CB - SG ANGL. DEV. = 6.7 DEGREES REMARK 500 ASP C 27 CB - CG - OD1 ANGL. DEV. = 6.9 DEGREES REMARK 500 ASP C 241 CB - CG - OD1 ANGL. DEV. = 6.2 DEGREES REMARK 500 ASP A 41 CB - CG - OD1 ANGL. DEV. = 6.7 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ARG B 62 94.77 -69.84 REMARK 500 THR B 206 -168.59 -129.73 REMARK 500 ILE B 297 -62.89 -96.27 REMARK 500 MET B 366 49.44 -94.26 REMARK 500 CYS B 442 34.57 -95.68 REMARK 500 ALA L 57 -9.54 72.53 REMARK 500 SER L 58 -37.38 -132.95 REMARK 500 SER L 69 114.55 -160.32 REMARK 500 SER D 85 60.13 60.78 REMARK 500 ALA F 57 -10.27 72.50 REMARK 500 SER F 58 -37.31 -132.88 REMARK 500 SER F 69 114.62 -160.30 REMARK 500 ALA G 57 -10.07 72.84 REMARK 500 SER G 58 -37.81 -132.47 REMARK 500 SER G 69 114.63 -160.94 REMARK 500 THR C 28 -166.72 -102.51 REMARK 500 ASP C 96 -103.17 -110.94 REMARK 500 ASN C 158 -112.67 52.69 REMARK 500 SER C 159 52.69 -144.67 REMARK 500 THR C 206 -169.47 -129.23 REMARK 500 ILE C 297 -62.00 -97.74 REMARK 500 ARG C 313 115.42 -162.51 REMARK 500 MET C 366 49.51 -94.64 REMARK 500 CYS C 442 33.08 -95.31 REMARK 500 GLU C 445 -51.14 -121.37 REMARK 500 TYR C 460 32.09 -99.93 REMARK 500 LEU A 96A 78.91 51.21 REMARK 500 SER A 146 -145.28 -139.95 REMARK 500 SER A 159 55.16 38.76 REMARK 500 THR A 160 114.64 -162.61 REMARK 500 THR A 206 -168.98 -128.82 REMARK 500 ASN A 276 99.41 -69.37 REMARK 500 ILE A 297 -62.64 -96.83 REMARK 500 MET A 366 49.66 -96.09 REMARK 500 CYS A 442 32.44 -94.23 REMARK 500 TYR A 460 32.02 -96.81 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-42377 RELATED DB: EMDB REMARK 900 INFLUENZA A VIRUS HEMAGGLUTININ H5/VIETNAM/1204/2004 IN COMPLEX REMARK 900 WITH D04 FAB DBREF1 8UME B 11 474 UNP A0A076G8X7_9INFA DBREF2 8UME B A0A076G8X7 17 518 DBREF 8UME H 1 228 PDB 8UME 8UME 1 228 DBREF 8UME L 1 221 PDB 8UME 8UME 1 221 DBREF 8UME D 1 228 PDB 8UME 8UME 1 228 DBREF 8UME F 1 221 PDB 8UME 8UME 1 221 DBREF 8UME E 1 228 PDB 8UME 8UME 1 228 DBREF 8UME G 1 221 PDB 8UME 8UME 1 221 DBREF1 8UME C 11 474 UNP A0A076G8X7_9INFA DBREF2 8UME C A0A076G8X7 17 518 DBREF1 8UME A 11 474 UNP A0A076G8X7_9INFA DBREF2 8UME A A0A076G8X7 17 518 SEQADV 8UME PHE B 98 UNP A0A076G8X TYR 107 CONFLICT SEQADV 8UME B UNP A0A076G8X THR 341 DELETION SEQADV 8UME ARG B 475 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER B 476 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY B 477 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ALA B 478 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY B 479 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER B 480 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER B 481 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY B 482 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER B 483 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY B 484 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG B 485 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME MET B 486 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS B 487 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLN B 488 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 489 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU B 490 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ASP B 491 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS B 492 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 493 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU B 494 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU B 495 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 496 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LEU B 497 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER B 498 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS B 499 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 500 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME TYR B 501 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME HIS B 502 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 503 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU B 504 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ASN B 505 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU B 506 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 507 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ALA B 508 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG B 509 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 510 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS B 511 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS B 512 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LEU B 513 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE B 514 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY B 515 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU B 516 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG B 517 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER B 518 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY B 519 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY B 520 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME PHE C 98 UNP A0A076G8X TYR 107 CONFLICT SEQADV 8UME C UNP A0A076G8X THR 341 DELETION SEQADV 8UME ARG C 475 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER C 476 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY C 477 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ALA C 478 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY C 479 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER C 480 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER C 481 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY C 482 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER C 483 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY C 484 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG C 485 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME MET C 486 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS C 487 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLN C 488 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 489 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU C 490 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ASP C 491 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS C 492 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 493 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU C 494 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU C 495 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 496 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LEU C 497 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER C 498 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS C 499 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 500 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME TYR C 501 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME HIS C 502 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 503 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU C 504 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ASN C 505 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU C 506 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 507 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ALA C 508 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG C 509 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 510 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS C 511 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS C 512 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LEU C 513 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE C 514 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY C 515 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU C 516 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG C 517 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER C 518 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY C 519 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY C 520 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME PHE A 98 UNP A0A076G8X TYR 107 CONFLICT SEQADV 8UME A UNP A0A076G8X THR 341 DELETION SEQADV 8UME ARG A 475 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER A 476 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY A 477 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ALA A 478 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY A 479 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER A 480 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER A 481 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY A 482 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER A 483 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY A 484 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG A 485 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME MET A 486 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS A 487 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLN A 488 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 489 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU A 490 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ASP A 491 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS A 492 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 493 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU A 494 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU A 495 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 496 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LEU A 497 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER A 498 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS A 499 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 500 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME TYR A 501 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME HIS A 502 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 503 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU A 504 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ASN A 505 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU A 506 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 507 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ALA A 508 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG A 509 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 510 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS A 511 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LYS A 512 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME LEU A 513 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ILE A 514 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY A 515 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLU A 516 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME ARG A 517 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME SER A 518 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY A 519 UNP A0A076G8X EXPRESSION TAG SEQADV 8UME GLY A 520 UNP A0A076G8X EXPRESSION TAG SEQRES 1 B 547 ASP GLN ILE CYS ILE GLY TYR HIS ALA ASN ASN SER THR SEQRES 2 B 547 GLU GLN VAL ASP THR ILE MET GLU LYS ASN VAL THR VAL SEQRES 3 B 547 THR HIS ALA GLN ASP ILE LEU GLU LYS LYS HIS ASN GLY SEQRES 4 B 547 LYS LEU CYS ASP LEU ASP GLY VAL LYS PRO LEU ILE LEU SEQRES 5 B 547 ARG ASP CYS SER VAL ALA GLY TRP LEU LEU GLY ASN PRO SEQRES 6 B 547 MET CYS ASP GLU PHE ILE ASN VAL PRO GLU TRP SER TYR SEQRES 7 B 547 ILE VAL GLU LYS ALA ASN PRO VAL ASN ASP LEU CYS PHE SEQRES 8 B 547 PRO GLY ASP PHE ASN ASP TYR GLU GLU LEU LYS HIS LEU SEQRES 9 B 547 LEU SER ARG ILE ASN HIS PHE GLU LYS ILE GLN ILE ILE SEQRES 10 B 547 PRO LYS SER SER TRP SER SER HIS GLU ALA SER LEU GLY SEQRES 11 B 547 VAL SER SER ALA CYS PRO TYR GLN GLY LYS SER SER PHE SEQRES 12 B 547 PHE ARG ASN VAL VAL TRP LEU ILE LYS LYS ASN SER THR SEQRES 13 B 547 TYR PRO THR ILE LYS ARG SER TYR ASN ASN THR ASN GLN SEQRES 14 B 547 GLU ASP LEU LEU VAL LEU TRP GLY ILE HIS HIS PRO ASN SEQRES 15 B 547 ASP ALA ALA GLU GLN THR LYS LEU TYR GLN ASN PRO THR SEQRES 16 B 547 THR TYR ILE SER VAL GLY THR SER THR LEU ASN GLN ARG SEQRES 17 B 547 LEU VAL PRO ARG ILE ALA THR ARG SER LYS VAL ASN GLY SEQRES 18 B 547 GLN SER GLY ARG MET GLU PHE PHE TRP THR ILE LEU LYS SEQRES 19 B 547 PRO ASN ASP ALA ILE ASN PHE GLU SER ASN GLY ASN PHE SEQRES 20 B 547 ILE ALA PRO GLU TYR ALA TYR LYS ILE VAL LYS LYS GLY SEQRES 21 B 547 ASP SER THR ILE MET LYS SER GLU LEU GLU TYR GLY ASN SEQRES 22 B 547 CYS ASN THR LYS CYS GLN THR PRO MET GLY ALA ILE ASN SEQRES 23 B 547 SER SER MET PRO PHE HIS ASN ILE HIS PRO LEU THR ILE SEQRES 24 B 547 GLY GLU CYS PRO LYS TYR VAL LYS SER ASN ARG LEU VAL SEQRES 25 B 547 LEU ALA THR GLY LEU ARG ASN SER PRO GLN ARG GLU ARG SEQRES 26 B 547 GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU GLY GLY SEQRES 27 B 547 TRP GLN GLY MET VAL ASP GLY TRP TYR GLY TYR HIS HIS SEQRES 28 B 547 SER ASN GLU GLN GLY SER GLY TYR ALA ALA ASP LYS GLU SEQRES 29 B 547 SER THR GLN LYS ALA ILE ASP GLY VAL THR ASN LYS VAL SEQRES 30 B 547 ASN SER ILE ILE ASP LYS MET ASN THR GLN PHE GLU ALA SEQRES 31 B 547 VAL GLY ARG GLU PHE ASN ASN LEU GLU ARG ARG ILE GLU SEQRES 32 B 547 ASN LEU ASN LYS LYS MET GLU ASP GLY PHE LEU ASP VAL SEQRES 33 B 547 TRP THR TYR ASN ALA GLU LEU LEU VAL LEU MET GLU ASN SEQRES 34 B 547 GLU ARG THR LEU ASP PHE HIS ASP SER ASN VAL LYS ASN SEQRES 35 B 547 LEU TYR ASP LYS VAL ARG LEU GLN LEU ARG ASP ASN ALA SEQRES 36 B 547 LYS GLU LEU GLY ASN GLY CYS PHE GLU PHE TYR HIS LYS SEQRES 37 B 547 CYS ASP ASN GLU CYS MET GLU SER VAL ARG ASN GLY THR SEQRES 38 B 547 TYR ASP TYR PRO GLN TYR SER GLU GLU ALA ARG LEU LYS SEQRES 39 B 547 ARG GLU GLU ILE SER GLY VAL ARG SER GLY ALA GLY SER SEQRES 40 B 547 SER GLY SER GLY ARG MET LYS GLN ILE GLU ASP LYS ILE SEQRES 41 B 547 GLU GLU ILE LEU SER LYS ILE TYR HIS ILE GLU ASN GLU SEQRES 42 B 547 ILE ALA ARG ILE LYS LYS LEU ILE GLY GLU ARG SER GLY SEQRES 43 B 547 GLY SEQRES 1 H 228 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 H 228 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 H 228 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 H 228 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 H 228 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 H 228 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 H 228 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 H 228 ALA VAL TYR TYR CYS ALA ARG ALA PRO ALA ALA ILE SER SEQRES 9 H 228 TYR TYR MET ASP VAL TRP GLY LYS GLY THR THR VAL THR SEQRES 10 H 228 VAL SER GLY ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 H 228 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 H 228 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 H 228 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 H 228 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 H 228 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 H 228 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 H 228 PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SEQRES 18 H 228 SER CYS ASP LYS GLY SER SER SEQRES 1 L 221 ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL SEQRES 2 L 221 SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER SEQRES 3 L 221 GLN SER VAL LEU TYR SER SER ASN ASN LYS ASN TYR LEU SEQRES 4 L 221 ALA TRP TYR GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU SEQRES 5 L 221 LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO SEQRES 6 L 221 ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR SEQRES 7 L 221 LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL SEQRES 8 L 221 TYR TYR CYS GLN GLN TYR TYR SER THR PRO ALA LEU THR SEQRES 9 L 221 PHE GLY GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL SEQRES 10 L 221 ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU SEQRES 11 L 221 GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU SEQRES 12 L 221 ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS SEQRES 13 L 221 VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER SEQRES 14 L 221 VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SEQRES 15 L 221 SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS SEQRES 16 L 221 HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SEQRES 17 L 221 SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 D 228 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 D 228 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 D 228 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 D 228 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 D 228 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 D 228 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 D 228 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 D 228 ALA VAL TYR TYR CYS ALA ARG ALA PRO ALA ALA ILE SER SEQRES 9 D 228 TYR TYR MET ASP VAL TRP GLY LYS GLY THR THR VAL THR SEQRES 10 D 228 VAL SER GLY ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 D 228 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 D 228 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 D 228 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 D 228 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 D 228 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 D 228 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 D 228 PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SEQRES 18 D 228 SER CYS ASP LYS GLY SER SER SEQRES 1 F 221 ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL SEQRES 2 F 221 SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER SEQRES 3 F 221 GLN SER VAL LEU TYR SER SER ASN ASN LYS ASN TYR LEU SEQRES 4 F 221 ALA TRP TYR GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU SEQRES 5 F 221 LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO SEQRES 6 F 221 ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR SEQRES 7 F 221 LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL SEQRES 8 F 221 TYR TYR CYS GLN GLN TYR TYR SER THR PRO ALA LEU THR SEQRES 9 F 221 PHE GLY GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL SEQRES 10 F 221 ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU SEQRES 11 F 221 GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU SEQRES 12 F 221 ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS SEQRES 13 F 221 VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER SEQRES 14 F 221 VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SEQRES 15 F 221 SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS SEQRES 16 F 221 HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SEQRES 17 F 221 SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 E 228 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 E 228 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 E 228 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 E 228 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 E 228 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 E 228 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 E 228 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 E 228 ALA VAL TYR TYR CYS ALA ARG ALA PRO ALA ALA ILE SER SEQRES 9 E 228 TYR TYR MET ASP VAL TRP GLY LYS GLY THR THR VAL THR SEQRES 10 E 228 VAL SER GLY ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 E 228 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 E 228 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 E 228 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 E 228 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 E 228 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 E 228 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 E 228 PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SEQRES 18 E 228 SER CYS ASP LYS GLY SER SER SEQRES 1 G 221 ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL SEQRES 2 G 221 SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER SEQRES 3 G 221 GLN SER VAL LEU TYR SER SER ASN ASN LYS ASN TYR LEU SEQRES 4 G 221 ALA TRP TYR GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU SEQRES 5 G 221 LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO SEQRES 6 G 221 ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR SEQRES 7 G 221 LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL SEQRES 8 G 221 TYR TYR CYS GLN GLN TYR TYR SER THR PRO ALA LEU THR SEQRES 9 G 221 PHE GLY GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL SEQRES 10 G 221 ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU SEQRES 11 G 221 GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU SEQRES 12 G 221 ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS SEQRES 13 G 221 VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER SEQRES 14 G 221 VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SEQRES 15 G 221 SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS SEQRES 16 G 221 HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SEQRES 17 G 221 SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 C 547 ASP GLN ILE CYS ILE GLY TYR HIS ALA ASN ASN SER THR SEQRES 2 C 547 GLU GLN VAL ASP THR ILE MET GLU LYS ASN VAL THR VAL SEQRES 3 C 547 THR HIS ALA GLN ASP ILE LEU GLU LYS LYS HIS ASN GLY SEQRES 4 C 547 LYS LEU CYS ASP LEU ASP GLY VAL LYS PRO LEU ILE LEU SEQRES 5 C 547 ARG ASP CYS SER VAL ALA GLY TRP LEU LEU GLY ASN PRO SEQRES 6 C 547 MET CYS ASP GLU PHE ILE ASN VAL PRO GLU TRP SER TYR SEQRES 7 C 547 ILE VAL GLU LYS ALA ASN PRO VAL ASN ASP LEU CYS PHE SEQRES 8 C 547 PRO GLY ASP PHE ASN ASP TYR GLU GLU LEU LYS HIS LEU SEQRES 9 C 547 LEU SER ARG ILE ASN HIS PHE GLU LYS ILE GLN ILE ILE SEQRES 10 C 547 PRO LYS SER SER TRP SER SER HIS GLU ALA SER LEU GLY SEQRES 11 C 547 VAL SER SER ALA CYS PRO TYR GLN GLY LYS SER SER PHE SEQRES 12 C 547 PHE ARG ASN VAL VAL TRP LEU ILE LYS LYS ASN SER THR SEQRES 13 C 547 TYR PRO THR ILE LYS ARG SER TYR ASN ASN THR ASN GLN SEQRES 14 C 547 GLU ASP LEU LEU VAL LEU TRP GLY ILE HIS HIS PRO ASN SEQRES 15 C 547 ASP ALA ALA GLU GLN THR LYS LEU TYR GLN ASN PRO THR SEQRES 16 C 547 THR TYR ILE SER VAL GLY THR SER THR LEU ASN GLN ARG SEQRES 17 C 547 LEU VAL PRO ARG ILE ALA THR ARG SER LYS VAL ASN GLY SEQRES 18 C 547 GLN SER GLY ARG MET GLU PHE PHE TRP THR ILE LEU LYS SEQRES 19 C 547 PRO ASN ASP ALA ILE ASN PHE GLU SER ASN GLY ASN PHE SEQRES 20 C 547 ILE ALA PRO GLU TYR ALA TYR LYS ILE VAL LYS LYS GLY SEQRES 21 C 547 ASP SER THR ILE MET LYS SER GLU LEU GLU TYR GLY ASN SEQRES 22 C 547 CYS ASN THR LYS CYS GLN THR PRO MET GLY ALA ILE ASN SEQRES 23 C 547 SER SER MET PRO PHE HIS ASN ILE HIS PRO LEU THR ILE SEQRES 24 C 547 GLY GLU CYS PRO LYS TYR VAL LYS SER ASN ARG LEU VAL SEQRES 25 C 547 LEU ALA THR GLY LEU ARG ASN SER PRO GLN ARG GLU ARG SEQRES 26 C 547 GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU GLY GLY SEQRES 27 C 547 TRP GLN GLY MET VAL ASP GLY TRP TYR GLY TYR HIS HIS SEQRES 28 C 547 SER ASN GLU GLN GLY SER GLY TYR ALA ALA ASP LYS GLU SEQRES 29 C 547 SER THR GLN LYS ALA ILE ASP GLY VAL THR ASN LYS VAL SEQRES 30 C 547 ASN SER ILE ILE ASP LYS MET ASN THR GLN PHE GLU ALA SEQRES 31 C 547 VAL GLY ARG GLU PHE ASN ASN LEU GLU ARG ARG ILE GLU SEQRES 32 C 547 ASN LEU ASN LYS LYS MET GLU ASP GLY PHE LEU ASP VAL SEQRES 33 C 547 TRP THR TYR ASN ALA GLU LEU LEU VAL LEU MET GLU ASN SEQRES 34 C 547 GLU ARG THR LEU ASP PHE HIS ASP SER ASN VAL LYS ASN SEQRES 35 C 547 LEU TYR ASP LYS VAL ARG LEU GLN LEU ARG ASP ASN ALA SEQRES 36 C 547 LYS GLU LEU GLY ASN GLY CYS PHE GLU PHE TYR HIS LYS SEQRES 37 C 547 CYS ASP ASN GLU CYS MET GLU SER VAL ARG ASN GLY THR SEQRES 38 C 547 TYR ASP TYR PRO GLN TYR SER GLU GLU ALA ARG LEU LYS SEQRES 39 C 547 ARG GLU GLU ILE SER GLY VAL ARG SER GLY ALA GLY SER SEQRES 40 C 547 SER GLY SER GLY ARG MET LYS GLN ILE GLU ASP LYS ILE SEQRES 41 C 547 GLU GLU ILE LEU SER LYS ILE TYR HIS ILE GLU ASN GLU SEQRES 42 C 547 ILE ALA ARG ILE LYS LYS LEU ILE GLY GLU ARG SER GLY SEQRES 43 C 547 GLY SEQRES 1 A 547 ASP GLN ILE CYS ILE GLY TYR HIS ALA ASN ASN SER THR SEQRES 2 A 547 GLU GLN VAL ASP THR ILE MET GLU LYS ASN VAL THR VAL SEQRES 3 A 547 THR HIS ALA GLN ASP ILE LEU GLU LYS LYS HIS ASN GLY SEQRES 4 A 547 LYS LEU CYS ASP LEU ASP GLY VAL LYS PRO LEU ILE LEU SEQRES 5 A 547 ARG ASP CYS SER VAL ALA GLY TRP LEU LEU GLY ASN PRO SEQRES 6 A 547 MET CYS ASP GLU PHE ILE ASN VAL PRO GLU TRP SER TYR SEQRES 7 A 547 ILE VAL GLU LYS ALA ASN PRO VAL ASN ASP LEU CYS PHE SEQRES 8 A 547 PRO GLY ASP PHE ASN ASP TYR GLU GLU LEU LYS HIS LEU SEQRES 9 A 547 LEU SER ARG ILE ASN HIS PHE GLU LYS ILE GLN ILE ILE SEQRES 10 A 547 PRO LYS SER SER TRP SER SER HIS GLU ALA SER LEU GLY SEQRES 11 A 547 VAL SER SER ALA CYS PRO TYR GLN GLY LYS SER SER PHE SEQRES 12 A 547 PHE ARG ASN VAL VAL TRP LEU ILE LYS LYS ASN SER THR SEQRES 13 A 547 TYR PRO THR ILE LYS ARG SER TYR ASN ASN THR ASN GLN SEQRES 14 A 547 GLU ASP LEU LEU VAL LEU TRP GLY ILE HIS HIS PRO ASN SEQRES 15 A 547 ASP ALA ALA GLU GLN THR LYS LEU TYR GLN ASN PRO THR SEQRES 16 A 547 THR TYR ILE SER VAL GLY THR SER THR LEU ASN GLN ARG SEQRES 17 A 547 LEU VAL PRO ARG ILE ALA THR ARG SER LYS VAL ASN GLY SEQRES 18 A 547 GLN SER GLY ARG MET GLU PHE PHE TRP THR ILE LEU LYS SEQRES 19 A 547 PRO ASN ASP ALA ILE ASN PHE GLU SER ASN GLY ASN PHE SEQRES 20 A 547 ILE ALA PRO GLU TYR ALA TYR LYS ILE VAL LYS LYS GLY SEQRES 21 A 547 ASP SER THR ILE MET LYS SER GLU LEU GLU TYR GLY ASN SEQRES 22 A 547 CYS ASN THR LYS CYS GLN THR PRO MET GLY ALA ILE ASN SEQRES 23 A 547 SER SER MET PRO PHE HIS ASN ILE HIS PRO LEU THR ILE SEQRES 24 A 547 GLY GLU CYS PRO LYS TYR VAL LYS SER ASN ARG LEU VAL SEQRES 25 A 547 LEU ALA THR GLY LEU ARG ASN SER PRO GLN ARG GLU ARG SEQRES 26 A 547 GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU GLY GLY SEQRES 27 A 547 TRP GLN GLY MET VAL ASP GLY TRP TYR GLY TYR HIS HIS SEQRES 28 A 547 SER ASN GLU GLN GLY SER GLY TYR ALA ALA ASP LYS GLU SEQRES 29 A 547 SER THR GLN LYS ALA ILE ASP GLY VAL THR ASN LYS VAL SEQRES 30 A 547 ASN SER ILE ILE ASP LYS MET ASN THR GLN PHE GLU ALA SEQRES 31 A 547 VAL GLY ARG GLU PHE ASN ASN LEU GLU ARG ARG ILE GLU SEQRES 32 A 547 ASN LEU ASN LYS LYS MET GLU ASP GLY PHE LEU ASP VAL SEQRES 33 A 547 TRP THR TYR ASN ALA GLU LEU LEU VAL LEU MET GLU ASN SEQRES 34 A 547 GLU ARG THR LEU ASP PHE HIS ASP SER ASN VAL LYS ASN SEQRES 35 A 547 LEU TYR ASP LYS VAL ARG LEU GLN LEU ARG ASP ASN ALA SEQRES 36 A 547 LYS GLU LEU GLY ASN GLY CYS PHE GLU PHE TYR HIS LYS SEQRES 37 A 547 CYS ASP ASN GLU CYS MET GLU SER VAL ARG ASN GLY THR SEQRES 38 A 547 TYR ASP TYR PRO GLN TYR SER GLU GLU ALA ARG LEU LYS SEQRES 39 A 547 ARG GLU GLU ILE SER GLY VAL ARG SER GLY ALA GLY SER SEQRES 40 A 547 SER GLY SER GLY ARG MET LYS GLN ILE GLU ASP LYS ILE SEQRES 41 A 547 GLU GLU ILE LEU SER LYS ILE TYR HIS ILE GLU ASN GLU SEQRES 42 A 547 ILE ALA ARG ILE LYS LYS LEU ILE GLY GLU ARG SER GLY SEQRES 43 A 547 GLY HET NAG B 601 14 HET NAG B 602 14 HET NAG B 603 14 HET NAG C 601 14 HET NAG C 602 14 HET NAG C 603 14 HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 10 NAG 9(C8 H15 N O6) HELIX 1 AA1 SER B 65 GLY B 72 1 8 HELIX 2 AA2 ASP B 104 SER B 113 1 10 HELIX 3 AA3 ASP B 187 TYR B 195 1 9 HELIX 4 AA4 ASP B 344 MET B 366 1 23 HELIX 5 AA5 GLU B 381 ARG B 434 1 54 HELIX 6 AA6 CYS B 446 ASN B 452 1 7 HELIX 7 AA7 TYR B 460 GLY B 473 1 14 HELIX 8 AA8 ARG H 87 THR H 91 5 5 HELIX 9 AA9 GLN L 85 VAL L 89 5 5 HELIX 10 AB1 ARG D 87 THR D 91 5 5 HELIX 11 AB2 GLN F 85 VAL F 89 5 5 HELIX 12 AB3 ARG E 87 THR E 91 5 5 HELIX 13 AB4 GLN G 85 VAL G 89 5 5 HELIX 14 AB5 SER C 65 GLY C 72 1 8 HELIX 15 AB6 ASP C 104 SER C 113 1 10 HELIX 16 AB7 PRO C 125 TRP C 127 5 5 HELIX 17 AB8 ASP C 187 TYR C 195 1 9 HELIX 18 AB9 ASP C 344 MET C 366 1 23 HELIX 19 AC1 GLU C 381 ARG C 434 1 54 HELIX 20 AC2 CYS C 446 ASN C 452 1 7 HELIX 21 AC3 TYR C 460 GLY C 473 1 14 HELIX 22 AC4 SER A 65 GLY A 72 1 8 HELIX 23 AC5 ASP A 104 SER A 113 1 10 HELIX 24 AC6 PRO A 125 TRP A 127 5 5 HELIX 25 AC7 ASP A 187 TYR A 195 1 9 HELIX 26 AC8 ASP A 344 GLY A 354 1 11 HELIX 27 AC9 GLY A 354 MET A 366 1 13 HELIX 28 AD1 GLU A 381 ARG A 434 1 54 HELIX 29 AD2 GLU A 445 ASN A 452 1 8 HELIX 30 AD3 TYR A 460 GLY A 473 1 14 SHEET 1 AA1 2 GLU B 24 VAL B 26 0 SHEET 2 AA1 2 VAL B 34 VAL B 36 -1 O VAL B 34 N VAL B 26 SHEET 1 AA2 2 ALA B 39 ASP B 41 0 SHEET 2 AA2 2 VAL B 315 ALA B 317 -1 O LEU B 316 N GLN B 40 SHEET 1 AA3 3 LEU B 43 GLU B 44 0 SHEET 2 AA3 3 PHE B 294 HIS B 295 1 O PHE B 294 N GLU B 44 SHEET 3 AA3 3 LYS B 307 TYR B 308 1 O LYS B 307 N HIS B 295 SHEET 1 AA4 3 LEU B 59 ILE B 60 0 SHEET 2 AA4 3 ILE B 87 GLU B 89 1 O VAL B 88 N LEU B 59 SHEET 3 AA4 3 ILE B 267 LYS B 269 1 O MET B 268 N ILE B 87 SHEET 1 AA5 5 PHE B 118 ILE B 121 0 SHEET 2 AA5 5 ALA B 257 ILE B 260 -1 O ALA B 257 N ILE B 121 SHEET 3 AA5 5 LEU B 176 HIS B 184 -1 N LEU B 177 O TYR B 258 SHEET 4 AA5 5 PHE B 251 PRO B 254 -1 O ILE B 252 N GLY B 181 SHEET 5 AA5 5 VAL B 151 TRP B 153 -1 N VAL B 152 O ALA B 253 SHEET 1 AA6 4 PHE B 118 ILE B 121 0 SHEET 2 AA6 4 ALA B 257 ILE B 260 -1 O ALA B 257 N ILE B 121 SHEET 3 AA6 4 LEU B 176 HIS B 184 -1 N LEU B 177 O TYR B 258 SHEET 4 AA6 4 ARG B 229 LEU B 237 -1 O PHE B 233 N TRP B 180 SHEET 1 AA7 2 HIS B 130 GLU B 131 0 SHEET 2 AA7 2 ILE B 155 LYS B 156 -1 O ILE B 155 N GLU B 131 SHEET 1 AA8 2 SER B 136 TYR B 141 0 SHEET 2 AA8 2 LYS B 144 SER B 146 -1 O SER B 146 N SER B 136 SHEET 1 AA9 2 ARG B 166 ASN B 169 0 SHEET 2 AA9 2 ALA B 242 PHE B 245 -1 O PHE B 245 N ARG B 166 SHEET 1 AB1 2 VAL B 204 THR B 206 0 SHEET 2 AB1 2 LEU B 209 GLN B 211 -1 O GLN B 211 N VAL B 204 SHEET 1 AB2 4 GLN H 3 SER H 7 0 SHEET 2 AB2 4 LEU H 18 SER H 25 -1 O ALA H 23 N VAL H 5 SHEET 3 AB2 4 SER H 78 MET H 83 -1 O LEU H 79 N CYS H 22 SHEET 4 AB2 4 PHE H 68 ASP H 73 -1 N SER H 71 O TYR H 80 SHEET 1 AB3 6 LEU H 11 VAL H 12 0 SHEET 2 AB3 6 THR H 114 VAL H 118 1 O THR H 117 N VAL H 12 SHEET 3 AB3 6 ALA H 92 ALA H 99 -1 N TYR H 94 O THR H 114 SHEET 4 AB3 6 SER H 33 GLN H 39 -1 N VAL H 37 O TYR H 95 SHEET 5 AB3 6 LEU H 45 ILE H 51 -1 O VAL H 48 N TRP H 36 SHEET 6 AB3 6 ILE H 58 TYR H 60 -1 O TYR H 59 N SER H 50 SHEET 1 AB4 4 MET L 4 GLN L 6 0 SHEET 2 AB4 4 ALA L 19 SER L 25 -1 O LYS L 24 N THR L 5 SHEET 3 AB4 4 ASP L 76 ILE L 81 -1 O PHE L 77 N CYS L 23 SHEET 4 AB4 4 PHE L 68 SER L 73 -1 N SER L 69 O THR L 80 SHEET 1 AB5 3 SER L 10 ALA L 12 0 SHEET 2 AB5 3 THR L 109 GLU L 112 1 O GLU L 112 N LEU L 11 SHEET 3 AB5 3 VAL L 91 TYR L 92 -1 N TYR L 92 O THR L 109 SHEET 1 AB6 4 THR L 59 ARG L 60 0 SHEET 2 AB6 4 ILE L 54 TYR L 55 -1 N TYR L 55 O THR L 59 SHEET 3 AB6 4 LEU L 39 TRP L 41 -1 N TRP L 41 O ILE L 54 SHEET 4 AB6 4 CYS L 94 GLN L 96 -1 O GLN L 95 N ALA L 40 SHEET 1 AB7 4 GLN D 3 SER D 7 0 SHEET 2 AB7 4 SER D 17 SER D 25 -1 O ALA D 23 N VAL D 5 SHEET 3 AB7 4 SER D 78 ASN D 84 -1 O LEU D 79 N CYS D 22 SHEET 4 AB7 4 THR D 69 ASP D 73 -1 N SER D 71 O TYR D 80 SHEET 1 AB8 6 LEU D 11 VAL D 12 0 SHEET 2 AB8 6 THR D 114 VAL D 118 1 O THR D 117 N VAL D 12 SHEET 3 AB8 6 ALA D 92 ALA D 99 -1 N TYR D 94 O THR D 114 SHEET 4 AB8 6 SER D 33 GLN D 39 -1 N VAL D 37 O TYR D 95 SHEET 5 AB8 6 LEU D 45 ILE D 51 -1 O VAL D 48 N TRP D 36 SHEET 6 AB8 6 ILE D 58 TYR D 60 -1 O TYR D 59 N SER D 50 SHEET 1 AB9 2 MET F 4 THR F 5 0 SHEET 2 AB9 2 LYS F 24 SER F 25 -1 O LYS F 24 N THR F 5 SHEET 1 AC1 3 SER F 10 VAL F 13 0 SHEET 2 AC1 3 THR F 109 ILE F 113 1 O GLU F 112 N LEU F 11 SHEET 3 AC1 3 VAL F 91 TYR F 92 -1 N TYR F 92 O THR F 109 SHEET 1 AC2 3 ALA F 19 ASN F 22 0 SHEET 2 AC2 3 ASP F 76 ILE F 81 -1 O ILE F 81 N ALA F 19 SHEET 3 AC2 3 PHE F 68 SER F 73 -1 N SER F 69 O THR F 80 SHEET 1 AC3 4 THR F 59 ARG F 60 0 SHEET 2 AC3 4 ILE F 54 TYR F 55 -1 N TYR F 55 O THR F 59 SHEET 3 AC3 4 LEU F 39 TRP F 41 -1 N TRP F 41 O ILE F 54 SHEET 4 AC3 4 CYS F 94 GLN F 96 -1 O GLN F 95 N ALA F 40 SHEET 1 AC4 4 GLN E 3 SER E 7 0 SHEET 2 AC4 4 LEU E 18 SER E 25 -1 O SER E 21 N SER E 7 SHEET 3 AC4 4 SER E 78 MET E 83 -1 O LEU E 79 N CYS E 22 SHEET 4 AC4 4 PHE E 68 ASP E 73 -1 N SER E 71 O TYR E 80 SHEET 1 AC5 6 LEU E 11 VAL E 12 0 SHEET 2 AC5 6 THR E 114 VAL E 118 1 O THR E 117 N VAL E 12 SHEET 3 AC5 6 ALA E 92 ALA E 99 -1 N TYR E 94 O THR E 114 SHEET 4 AC5 6 SER E 33 GLN E 39 -1 N VAL E 37 O TYR E 95 SHEET 5 AC5 6 LEU E 45 ILE E 51 -1 O VAL E 48 N TRP E 36 SHEET 6 AC5 6 ILE E 58 TYR E 60 -1 O TYR E 59 N SER E 50 SHEET 1 AC6 4 LEU E 11 VAL E 12 0 SHEET 2 AC6 4 THR E 114 VAL E 118 1 O THR E 117 N VAL E 12 SHEET 3 AC6 4 ALA E 92 ALA E 99 -1 N TYR E 94 O THR E 114 SHEET 4 AC6 4 VAL E 109 TRP E 110 -1 O VAL E 109 N ARG E 98 SHEET 1 AC7 2 MET G 4 THR G 5 0 SHEET 2 AC7 2 LYS G 24 SER G 25 -1 O LYS G 24 N THR G 5 SHEET 1 AC8 6 SER G 10 VAL G 13 0 SHEET 2 AC8 6 THR G 109 ILE G 113 1 O GLU G 112 N LEU G 11 SHEET 3 AC8 6 VAL G 91 GLN G 96 -1 N TYR G 92 O THR G 109 SHEET 4 AC8 6 LEU G 39 GLN G 44 -1 N TYR G 42 O TYR G 93 SHEET 5 AC8 6 LYS G 51 TYR G 55 -1 O LEU G 53 N TRP G 41 SHEET 6 AC8 6 THR G 59 ARG G 60 -1 O THR G 59 N TYR G 55 SHEET 1 AC9 3 ALA G 19 ASN G 22 0 SHEET 2 AC9 3 ASP G 76 ILE G 81 -1 O ILE G 81 N ALA G 19 SHEET 3 AC9 3 PHE G 68 SER G 73 -1 N SER G 69 O THR G 80 SHEET 1 AD1 2 GLU C 24 VAL C 26 0 SHEET 2 AD1 2 VAL C 34 VAL C 36 -1 O VAL C 34 N VAL C 26 SHEET 1 AD2 2 ALA C 39 ASP C 41 0 SHEET 2 AD2 2 VAL C 315 ALA C 317 -1 O LEU C 316 N GLN C 40 SHEET 1 AD3 3 LEU C 43 GLU C 44 0 SHEET 2 AD3 3 PHE C 294 HIS C 295 1 O PHE C 294 N GLU C 44 SHEET 3 AD3 3 LYS C 307 TYR C 308 1 O LYS C 307 N HIS C 295 SHEET 1 AD4 3 LEU C 59 ILE C 60 0 SHEET 2 AD4 3 ILE C 87 GLU C 89 1 O VAL C 88 N LEU C 59 SHEET 3 AD4 3 ILE C 267 LYS C 269 1 O MET C 268 N ILE C 87 SHEET 1 AD5 5 PHE C 118 GLU C 119 0 SHEET 2 AD5 5 ALA C 257 ILE C 260 -1 O LYS C 259 N GLU C 119 SHEET 3 AD5 5 LEU C 176 HIS C 184 -1 N LEU C 177 O TYR C 258 SHEET 4 AD5 5 PHE C 251 PRO C 254 -1 O ILE C 252 N GLY C 181 SHEET 5 AD5 5 VAL C 151 TRP C 153 -1 N VAL C 152 O ALA C 253 SHEET 1 AD6 4 PHE C 118 GLU C 119 0 SHEET 2 AD6 4 ALA C 257 ILE C 260 -1 O LYS C 259 N GLU C 119 SHEET 3 AD6 4 LEU C 176 HIS C 184 -1 N LEU C 177 O TYR C 258 SHEET 4 AD6 4 ARG C 229 LEU C 237 -1 O LEU C 237 N LEU C 176 SHEET 1 AD7 2 HIS C 130 GLU C 131 0 SHEET 2 AD7 2 ILE C 155 LYS C 156 -1 O ILE C 155 N GLU C 131 SHEET 1 AD8 2 SER C 136 TYR C 141 0 SHEET 2 AD8 2 LYS C 144 SER C 146 -1 O LYS C 144 N TYR C 141 SHEET 1 AD9 2 ARG C 166 ASN C 169 0 SHEET 2 AD9 2 ALA C 242 PHE C 245 -1 O PHE C 245 N ARG C 166 SHEET 1 AE1 2 SER C 203 THR C 206 0 SHEET 2 AE1 2 LEU C 209 ARG C 212 -1 O GLN C 211 N VAL C 204 SHEET 1 AE2 2 CYS C 281 GLN C 282 0 SHEET 2 AE2 2 ILE C 302 GLY C 303 -1 O ILE C 302 N GLN C 282 SHEET 1 AE3 2 GLU A 24 VAL A 26 0 SHEET 2 AE3 2 VAL A 34 VAL A 36 -1 O VAL A 34 N VAL A 26 SHEET 1 AE4 3 LEU A 43 GLU A 44 0 SHEET 2 AE4 3 PHE A 294 HIS A 295 1 O PHE A 294 N GLU A 44 SHEET 3 AE4 3 LYS A 307 TYR A 308 1 O LYS A 307 N HIS A 295 SHEET 1 AE5 3 LEU A 59 ILE A 60 0 SHEET 2 AE5 3 ILE A 87 VAL A 88 1 O VAL A 88 N LEU A 59 SHEET 3 AE5 3 ILE A 267 MET A 268 1 O MET A 268 N ILE A 87 SHEET 1 AE6 5 PHE A 118 GLU A 119 0 SHEET 2 AE6 5 ALA A 257 ILE A 260 -1 O LYS A 259 N GLU A 119 SHEET 3 AE6 5 LEU A 176 HIS A 184 -1 N LEU A 177 O TYR A 258 SHEET 4 AE6 5 PHE A 251 PRO A 254 -1 O ILE A 252 N GLY A 181 SHEET 5 AE6 5 VAL A 151 TRP A 153 -1 N VAL A 152 O ALA A 253 SHEET 1 AE7 4 PHE A 118 GLU A 119 0 SHEET 2 AE7 4 ALA A 257 ILE A 260 -1 O LYS A 259 N GLU A 119 SHEET 3 AE7 4 LEU A 176 HIS A 184 -1 N LEU A 177 O TYR A 258 SHEET 4 AE7 4 ARG A 229 LEU A 237 -1 O LEU A 237 N LEU A 176 SHEET 1 AE8 2 HIS A 130 GLU A 131 0 SHEET 2 AE8 2 ILE A 155 LYS A 156 -1 O ILE A 155 N GLU A 131 SHEET 1 AE9 2 SER A 136 TYR A 141 0 SHEET 2 AE9 2 LYS A 144 SER A 146 -1 O LYS A 144 N TYR A 141 SHEET 1 AF1 4 ILE A 164 ASN A 169 0 SHEET 2 AF1 4 ALA A 242 SER A 247 -1 O SER A 247 N ILE A 164 SHEET 3 AF1 4 ILE A 202 THR A 206 -1 N SER A 203 O GLU A 246 SHEET 4 AF1 4 LEU A 209 ARG A 212 -1 O GLN A 211 N VAL A 204 SHEET 1 AF2 2 CYS A 281 GLN A 282 0 SHEET 2 AF2 2 ILE A 302 GLY A 303 -1 O ILE A 302 N GLN A 282 SSBOND 1 CYS B 52 CYS B 277 1555 1555 2.04 SSBOND 2 CYS B 64 CYS B 76 1555 1555 2.02 SSBOND 3 CYS B 97 CYS B 139 1555 1555 2.03 SSBOND 4 CYS B 281 CYS B 305 1555 1555 2.03 SSBOND 5 CYS B 442 CYS B 446 1555 1555 2.03 SSBOND 6 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 7 CYS L 23 CYS L 94 1555 1555 2.04 SSBOND 8 CYS D 22 CYS D 96 1555 1555 2.03 SSBOND 9 CYS F 23 CYS F 94 1555 1555 2.03 SSBOND 10 CYS E 22 CYS E 96 1555 1555 2.03 SSBOND 11 CYS G 23 CYS G 94 1555 1555 2.03 SSBOND 12 CYS C 52 CYS C 277 1555 1555 2.04 SSBOND 13 CYS C 64 CYS C 76 1555 1555 2.02 SSBOND 14 CYS C 97 CYS C 139 1555 1555 2.03 SSBOND 15 CYS C 281 CYS C 305 1555 1555 2.03 SSBOND 16 CYS C 442 CYS C 446 1555 1555 2.03 SSBOND 17 CYS A 52 CYS A 277 1555 1555 2.04 SSBOND 18 CYS A 64 CYS A 76 1555 1555 2.03 SSBOND 19 CYS A 97 CYS A 139 1555 1555 2.03 SSBOND 20 CYS A 281 CYS A 305 1555 1555 2.03 SSBOND 21 CYS A 442 CYS A 446 1555 1555 2.03 LINK ND2 ASN B 33 C1 NAG B 602 1555 1555 1.44 LINK ND2 ASN B 158 C1 NAG B 603 1555 1555 1.43 LINK ND2 ASN B 169 C1 NAG B 601 1555 1555 1.45 LINK ND2 ASN C 33 C1 NAG C 602 1555 1555 1.43 LINK ND2 ASN C 158 C1 NAG C 603 1555 1555 1.44 LINK ND2 ASN C 169 C1 NAG C 601 1555 1555 1.43 LINK ND2 ASN A 33 C1 NAG A 602 1555 1555 1.43 LINK ND2 ASN A 158 C1 NAG A 603 1555 1555 1.45 LINK ND2 ASN A 169 C1 NAG A 601 1555 1555 1.43 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000