HEADER IMMUNE SYSTEM/VIRAL PROTEIN 18-DEC-23 8VEB TITLE CRYO-EM STRUCTURE OF ANTIBODY T5-1E08 IN COMPLEX WITH STABILIZED H1N1 TITLE 2 INFLUENZA HEMAGGLUTININ TRIMER (A/KIEV/1/57) COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: A, C, E; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: T5-1E08 FAB HEAVY CHAIN; COMPND 7 CHAIN: G, H, J; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: T5-1E08 FAB LIGHT CHAIN; COMPND 11 CHAIN: I, K, L; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 11320; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_TAXID: 9606; SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS BROADLY NEUTRALIZING ANTIBODY, GROUP 1, INFLUENZA, ANTIBODY KEYWDS 2 MATURATION, CRYO-EM, FAB, HEMAGGLUTININ, TRIMER, SPIKE, IMMUNE KEYWDS 3 SYSTEM, VIRAL PROTEIN, IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.CERUTTI,L.SHAPIRO REVDAT 1 19-MAR-25 8VEB 0 JRNL AUTH G.CERUTTI,L.SHAPIRO JRNL TITL CRYO-EM STRUCTURE OF ANTIBODY T5-1E08 IN COMPLEX WITH JRNL TITL 2 STABILIZED H1N1 INFLUENZA HEMAGGLUTININ TRIMER (A/KIEV/1/57) JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.97 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.970 REMARK 3 NUMBER OF PARTICLES : 685608 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8VEB COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-DEC-23. REMARK 100 THE DEPOSITION ID IS D_1000276609. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : ANTIBODY T5-1E08 FAB IN COMPLEX REMARK 245 WITH INFLUENZA HEMAGGLUTININ REMARK 245 TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.20 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5180.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, G, H, I, J, K, L, M, REMARK 350 AND CHAINS: N, O, P, Q, R REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -6 REMARK 465 LYS A -5 REMARK 465 ALA A -4 REMARK 465 LYS A -3 REMARK 465 LEU A -2 REMARK 465 LEU A -1 REMARK 465 ILE A 0 REMARK 465 LEU A 1 REMARK 465 LEU A 2 REMARK 465 CYS A 3 REMARK 465 ALA A 4 REMARK 465 LEU A 5 REMARK 465 SER A 6 REMARK 465 ALA A 7 REMARK 465 THR A 8 REMARK 465 ASP A 9 REMARK 465 ALA A 10 REMARK 465 PHE A 333 REMARK 465 GLN A 334 REMARK 465 SER A 335 REMARK 465 ARG A 336 REMARK 465 GLY A 1001 REMARK 465 LEU A 1002 REMARK 465 PHE A 1003 REMARK 465 GLY A 1004 REMARK 465 ASP A 1174 REMARK 465 GLY A 1175 REMARK 465 SER A 1176 REMARK 465 GLY A 1177 REMARK 465 TYR A 1178 REMARK 465 ILE A 1179 REMARK 465 PRO A 1180 REMARK 465 GLU A 1181 REMARK 465 ALA A 1182 REMARK 465 PRO A 1183 REMARK 465 ARG A 1184 REMARK 465 ASP A 1185 REMARK 465 GLY A 1186 REMARK 465 GLN A 1187 REMARK 465 ALA A 1188 REMARK 465 TYR A 1189 REMARK 465 VAL A 1190 REMARK 465 ARG A 1191 REMARK 465 LYS A 1192 REMARK 465 ASP A 1193 REMARK 465 GLY A 1194 REMARK 465 GLU A 1195 REMARK 465 TRP A 1196 REMARK 465 VAL A 1197 REMARK 465 LEU A 1198 REMARK 465 LEU A 1199 REMARK 465 SER A 1200 REMARK 465 THR A 1201 REMARK 465 PHE A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 SER A 1205 REMARK 465 GLY A 1206 REMARK 465 LEU A 1207 REMARK 465 ASN A 1208 REMARK 465 ASP A 1209 REMARK 465 ILE A 1210 REMARK 465 PHE A 1211 REMARK 465 GLU A 1212 REMARK 465 ALA A 1213 REMARK 465 GLN A 1214 REMARK 465 LYS A 1215 REMARK 465 ILE A 1216 REMARK 465 GLU A 1217 REMARK 465 TRP A 1218 REMARK 465 HIS A 1219 REMARK 465 GLU A 1220 REMARK 465 GLY A 1221 REMARK 465 HIS A 1222 REMARK 465 HIS A 1223 REMARK 465 HIS A 1224 REMARK 465 HIS A 1225 REMARK 465 HIS A 1226 REMARK 465 HIS A 1227 REMARK 465 MET C -6 REMARK 465 LYS C -5 REMARK 465 ALA C -4 REMARK 465 LYS C -3 REMARK 465 LEU C -2 REMARK 465 LEU C -1 REMARK 465 ILE C 0 REMARK 465 LEU C 1 REMARK 465 LEU C 2 REMARK 465 CYS C 3 REMARK 465 ALA C 4 REMARK 465 LEU C 5 REMARK 465 SER C 6 REMARK 465 ALA C 7 REMARK 465 THR C 8 REMARK 465 ASP C 9 REMARK 465 ALA C 10 REMARK 465 PHE C 333 REMARK 465 GLN C 334 REMARK 465 SER C 335 REMARK 465 ARG C 336 REMARK 465 GLY C 1001 REMARK 465 LEU C 1002 REMARK 465 PHE C 1003 REMARK 465 GLY C 1004 REMARK 465 ASP C 1174 REMARK 465 GLY C 1175 REMARK 465 SER C 1176 REMARK 465 GLY C 1177 REMARK 465 TYR C 1178 REMARK 465 ILE C 1179 REMARK 465 PRO C 1180 REMARK 465 GLU C 1181 REMARK 465 ALA C 1182 REMARK 465 PRO C 1183 REMARK 465 ARG C 1184 REMARK 465 ASP C 1185 REMARK 465 GLY C 1186 REMARK 465 GLN C 1187 REMARK 465 ALA C 1188 REMARK 465 TYR C 1189 REMARK 465 VAL C 1190 REMARK 465 ARG C 1191 REMARK 465 LYS C 1192 REMARK 465 ASP C 1193 REMARK 465 GLY C 1194 REMARK 465 GLU C 1195 REMARK 465 TRP C 1196 REMARK 465 VAL C 1197 REMARK 465 LEU C 1198 REMARK 465 LEU C 1199 REMARK 465 SER C 1200 REMARK 465 THR C 1201 REMARK 465 PHE C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 SER C 1205 REMARK 465 GLY C 1206 REMARK 465 LEU C 1207 REMARK 465 ASN C 1208 REMARK 465 ASP C 1209 REMARK 465 ILE C 1210 REMARK 465 PHE C 1211 REMARK 465 GLU C 1212 REMARK 465 ALA C 1213 REMARK 465 GLN C 1214 REMARK 465 LYS C 1215 REMARK 465 ILE C 1216 REMARK 465 GLU C 1217 REMARK 465 TRP C 1218 REMARK 465 HIS C 1219 REMARK 465 GLU C 1220 REMARK 465 GLY C 1221 REMARK 465 HIS C 1222 REMARK 465 HIS C 1223 REMARK 465 HIS C 1224 REMARK 465 HIS C 1225 REMARK 465 HIS C 1226 REMARK 465 HIS C 1227 REMARK 465 MET E -6 REMARK 465 LYS E -5 REMARK 465 ALA E -4 REMARK 465 LYS E -3 REMARK 465 LEU E -2 REMARK 465 LEU E -1 REMARK 465 ILE E 0 REMARK 465 LEU E 1 REMARK 465 LEU E 2 REMARK 465 CYS E 3 REMARK 465 ALA E 4 REMARK 465 LEU E 5 REMARK 465 SER E 6 REMARK 465 ALA E 7 REMARK 465 THR E 8 REMARK 465 ASP E 9 REMARK 465 ALA E 10 REMARK 465 PHE E 333 REMARK 465 GLN E 334 REMARK 465 SER E 335 REMARK 465 ARG E 336 REMARK 465 GLY E 1001 REMARK 465 LEU E 1002 REMARK 465 PHE E 1003 REMARK 465 GLY E 1004 REMARK 465 ASP E 1174 REMARK 465 GLY E 1175 REMARK 465 SER E 1176 REMARK 465 GLY E 1177 REMARK 465 TYR E 1178 REMARK 465 ILE E 1179 REMARK 465 PRO E 1180 REMARK 465 GLU E 1181 REMARK 465 ALA E 1182 REMARK 465 PRO E 1183 REMARK 465 ARG E 1184 REMARK 465 ASP E 1185 REMARK 465 GLY E 1186 REMARK 465 GLN E 1187 REMARK 465 ALA E 1188 REMARK 465 TYR E 1189 REMARK 465 VAL E 1190 REMARK 465 ARG E 1191 REMARK 465 LYS E 1192 REMARK 465 ASP E 1193 REMARK 465 GLY E 1194 REMARK 465 GLU E 1195 REMARK 465 TRP E 1196 REMARK 465 VAL E 1197 REMARK 465 LEU E 1198 REMARK 465 LEU E 1199 REMARK 465 SER E 1200 REMARK 465 THR E 1201 REMARK 465 PHE E 1202 REMARK 465 LEU E 1203 REMARK 465 GLY E 1204 REMARK 465 SER E 1205 REMARK 465 GLY E 1206 REMARK 465 LEU E 1207 REMARK 465 ASN E 1208 REMARK 465 ASP E 1209 REMARK 465 ILE E 1210 REMARK 465 PHE E 1211 REMARK 465 GLU E 1212 REMARK 465 ALA E 1213 REMARK 465 GLN E 1214 REMARK 465 LYS E 1215 REMARK 465 ILE E 1216 REMARK 465 GLU E 1217 REMARK 465 TRP E 1218 REMARK 465 HIS E 1219 REMARK 465 GLU E 1220 REMARK 465 GLY E 1221 REMARK 465 HIS E 1222 REMARK 465 HIS E 1223 REMARK 465 HIS E 1224 REMARK 465 HIS E 1225 REMARK 465 HIS E 1226 REMARK 465 HIS E 1227 REMARK 465 VAL G 111 REMARK 465 SER G 112 REMARK 465 SER G 113 REMARK 465 ALA G 114 REMARK 465 SER G 115 REMARK 465 THR G 116 REMARK 465 LYS G 117 REMARK 465 GLY G 118 REMARK 465 PRO G 119 REMARK 465 SER G 120 REMARK 465 VAL G 121 REMARK 465 PHE G 122 REMARK 465 PRO G 123 REMARK 465 LEU G 124 REMARK 465 ALA G 125 REMARK 465 PRO G 126 REMARK 465 SER G 127 REMARK 465 SER G 128 REMARK 465 LYS G 129 REMARK 465 SER G 130 REMARK 465 THR G 131 REMARK 465 SER G 132 REMARK 465 GLY G 133 REMARK 465 GLY G 134 REMARK 465 THR G 135 REMARK 465 ALA G 136 REMARK 465 ALA G 137 REMARK 465 LEU G 138 REMARK 465 GLY G 139 REMARK 465 CYS G 140 REMARK 465 LEU G 141 REMARK 465 VAL G 142 REMARK 465 LYS G 143 REMARK 465 ASP G 144 REMARK 465 TYR G 145 REMARK 465 PHE G 146 REMARK 465 PRO G 147 REMARK 465 GLU G 148 REMARK 465 PRO G 149 REMARK 465 VAL G 150 REMARK 465 THR G 151 REMARK 465 VAL G 152 REMARK 465 SER G 153 REMARK 465 TRP G 154 REMARK 465 ASN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ALA G 158 REMARK 465 LEU G 159 REMARK 465 THR G 160 REMARK 465 SER G 161 REMARK 465 GLY G 162 REMARK 465 VAL G 163 REMARK 465 HIS G 164 REMARK 465 THR G 165 REMARK 465 PHE G 166 REMARK 465 PRO G 167 REMARK 465 ALA G 168 REMARK 465 VAL G 169 REMARK 465 LEU G 170 REMARK 465 GLN G 171 REMARK 465 SER G 172 REMARK 465 SER G 173 REMARK 465 GLY G 174 REMARK 465 LEU G 175 REMARK 465 TYR G 176 REMARK 465 SER G 177 REMARK 465 LEU G 178 REMARK 465 SER G 179 REMARK 465 SER G 180 REMARK 465 VAL G 181 REMARK 465 VAL G 182 REMARK 465 THR G 183 REMARK 465 VAL G 184 REMARK 465 PRO G 185 REMARK 465 SER G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 LEU G 189 REMARK 465 GLY G 190 REMARK 465 THR G 191 REMARK 465 GLN G 192 REMARK 465 THR G 193 REMARK 465 TYR G 194 REMARK 465 ILE G 195 REMARK 465 CYS G 196 REMARK 465 ASN G 197 REMARK 465 VAL G 198 REMARK 465 ASN G 199 REMARK 465 HIS G 200 REMARK 465 LYS G 201 REMARK 465 PRO G 202 REMARK 465 SER G 203 REMARK 465 ASN G 204 REMARK 465 THR G 205 REMARK 465 LYS G 206 REMARK 465 VAL G 207 REMARK 465 ASP G 208 REMARK 465 LYS G 209 REMARK 465 LYS G 210 REMARK 465 VAL G 211 REMARK 465 GLU G 212 REMARK 465 PRO G 213 REMARK 465 LYS G 214 REMARK 465 SER G 215 REMARK 465 CYS G 216 REMARK 465 ASP G 217 REMARK 465 LYS G 218 REMARK 465 THR G 219 REMARK 465 HIS G 220 REMARK 465 VAL H 111 REMARK 465 SER H 112 REMARK 465 SER H 113 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 LYS H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 THR H 219 REMARK 465 HIS H 220 REMARK 465 ILE I 106 REMARK 465 LYS I 107 REMARK 465 ARG I 108 REMARK 465 THR I 109 REMARK 465 VAL I 110 REMARK 465 ALA I 111 REMARK 465 ALA I 112 REMARK 465 PRO I 113 REMARK 465 SER I 114 REMARK 465 VAL I 115 REMARK 465 PHE I 116 REMARK 465 ILE I 117 REMARK 465 PHE I 118 REMARK 465 PRO I 119 REMARK 465 PRO I 120 REMARK 465 SER I 121 REMARK 465 ASP I 122 REMARK 465 GLU I 123 REMARK 465 GLN I 124 REMARK 465 LEU I 125 REMARK 465 LYS I 126 REMARK 465 SER I 127 REMARK 465 GLY I 128 REMARK 465 THR I 129 REMARK 465 ALA I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 VAL I 133 REMARK 465 CYS I 134 REMARK 465 LEU I 135 REMARK 465 LEU I 136 REMARK 465 ASN I 137 REMARK 465 ASN I 138 REMARK 465 PHE I 139 REMARK 465 TYR I 140 REMARK 465 PRO I 141 REMARK 465 ARG I 142 REMARK 465 GLU I 143 REMARK 465 ALA I 144 REMARK 465 LYS I 145 REMARK 465 VAL I 146 REMARK 465 GLN I 147 REMARK 465 TRP I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 ASP I 151 REMARK 465 ASN I 152 REMARK 465 ALA I 153 REMARK 465 LEU I 154 REMARK 465 GLN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLN I 160 REMARK 465 GLU I 161 REMARK 465 SER I 162 REMARK 465 VAL I 163 REMARK 465 THR I 164 REMARK 465 GLU I 165 REMARK 465 GLN I 166 REMARK 465 ASP I 167 REMARK 465 SER I 168 REMARK 465 LYS I 169 REMARK 465 ASP I 170 REMARK 465 SER I 171 REMARK 465 THR I 172 REMARK 465 TYR I 173 REMARK 465 SER I 174 REMARK 465 LEU I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 THR I 178 REMARK 465 LEU I 179 REMARK 465 THR I 180 REMARK 465 LEU I 181 REMARK 465 SER I 182 REMARK 465 LYS I 183 REMARK 465 ALA I 184 REMARK 465 ASP I 185 REMARK 465 TYR I 186 REMARK 465 GLU I 187 REMARK 465 LYS I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 VAL I 191 REMARK 465 TYR I 192 REMARK 465 ALA I 193 REMARK 465 CYS I 194 REMARK 465 GLU I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLN I 199 REMARK 465 GLY I 200 REMARK 465 LEU I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 PRO I 204 REMARK 465 VAL I 205 REMARK 465 THR I 206 REMARK 465 LYS I 207 REMARK 465 SER I 208 REMARK 465 PHE I 209 REMARK 465 ASN I 210 REMARK 465 ARG I 211 REMARK 465 GLY I 212 REMARK 465 GLU I 213 REMARK 465 CYS I 214 REMARK 465 VAL J 111 REMARK 465 SER J 112 REMARK 465 SER J 113 REMARK 465 ALA J 114 REMARK 465 SER J 115 REMARK 465 THR J 116 REMARK 465 LYS J 117 REMARK 465 GLY J 118 REMARK 465 PRO J 119 REMARK 465 SER J 120 REMARK 465 VAL J 121 REMARK 465 PHE J 122 REMARK 465 PRO J 123 REMARK 465 LEU J 124 REMARK 465 ALA J 125 REMARK 465 PRO J 126 REMARK 465 SER J 127 REMARK 465 SER J 128 REMARK 465 LYS J 129 REMARK 465 SER J 130 REMARK 465 THR J 131 REMARK 465 SER J 132 REMARK 465 GLY J 133 REMARK 465 GLY J 134 REMARK 465 THR J 135 REMARK 465 ALA J 136 REMARK 465 ALA J 137 REMARK 465 LEU J 138 REMARK 465 GLY J 139 REMARK 465 CYS J 140 REMARK 465 LEU J 141 REMARK 465 VAL J 142 REMARK 465 LYS J 143 REMARK 465 ASP J 144 REMARK 465 TYR J 145 REMARK 465 PHE J 146 REMARK 465 PRO J 147 REMARK 465 GLU J 148 REMARK 465 PRO J 149 REMARK 465 VAL J 150 REMARK 465 THR J 151 REMARK 465 VAL J 152 REMARK 465 SER J 153 REMARK 465 TRP J 154 REMARK 465 ASN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ALA J 158 REMARK 465 LEU J 159 REMARK 465 THR J 160 REMARK 465 SER J 161 REMARK 465 GLY J 162 REMARK 465 VAL J 163 REMARK 465 HIS J 164 REMARK 465 THR J 165 REMARK 465 PHE J 166 REMARK 465 PRO J 167 REMARK 465 ALA J 168 REMARK 465 VAL J 169 REMARK 465 LEU J 170 REMARK 465 GLN J 171 REMARK 465 SER J 172 REMARK 465 SER J 173 REMARK 465 GLY J 174 REMARK 465 LEU J 175 REMARK 465 TYR J 176 REMARK 465 SER J 177 REMARK 465 LEU J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 VAL J 181 REMARK 465 VAL J 182 REMARK 465 THR J 183 REMARK 465 VAL J 184 REMARK 465 PRO J 185 REMARK 465 SER J 186 REMARK 465 SER J 187 REMARK 465 SER J 188 REMARK 465 LEU J 189 REMARK 465 GLY J 190 REMARK 465 THR J 191 REMARK 465 GLN J 192 REMARK 465 THR J 193 REMARK 465 TYR J 194 REMARK 465 ILE J 195 REMARK 465 CYS J 196 REMARK 465 ASN J 197 REMARK 465 VAL J 198 REMARK 465 ASN J 199 REMARK 465 HIS J 200 REMARK 465 LYS J 201 REMARK 465 PRO J 202 REMARK 465 SER J 203 REMARK 465 ASN J 204 REMARK 465 THR J 205 REMARK 465 LYS J 206 REMARK 465 VAL J 207 REMARK 465 ASP J 208 REMARK 465 LYS J 209 REMARK 465 LYS J 210 REMARK 465 VAL J 211 REMARK 465 GLU J 212 REMARK 465 PRO J 213 REMARK 465 LYS J 214 REMARK 465 SER J 215 REMARK 465 CYS J 216 REMARK 465 ASP J 217 REMARK 465 LYS J 218 REMARK 465 THR J 219 REMARK 465 HIS J 220 REMARK 465 ILE K 106 REMARK 465 LYS K 107 REMARK 465 ARG K 108 REMARK 465 THR K 109 REMARK 465 VAL K 110 REMARK 465 ALA K 111 REMARK 465 ALA K 112 REMARK 465 PRO K 113 REMARK 465 SER K 114 REMARK 465 VAL K 115 REMARK 465 PHE K 116 REMARK 465 ILE K 117 REMARK 465 PHE K 118 REMARK 465 PRO K 119 REMARK 465 PRO K 120 REMARK 465 SER K 121 REMARK 465 ASP K 122 REMARK 465 GLU K 123 REMARK 465 GLN K 124 REMARK 465 LEU K 125 REMARK 465 LYS K 126 REMARK 465 SER K 127 REMARK 465 GLY K 128 REMARK 465 THR K 129 REMARK 465 ALA K 130 REMARK 465 SER K 131 REMARK 465 VAL K 132 REMARK 465 VAL K 133 REMARK 465 CYS K 134 REMARK 465 LEU K 135 REMARK 465 LEU K 136 REMARK 465 ASN K 137 REMARK 465 ASN K 138 REMARK 465 PHE K 139 REMARK 465 TYR K 140 REMARK 465 PRO K 141 REMARK 465 ARG K 142 REMARK 465 GLU K 143 REMARK 465 ALA K 144 REMARK 465 LYS K 145 REMARK 465 VAL K 146 REMARK 465 GLN K 147 REMARK 465 TRP K 148 REMARK 465 LYS K 149 REMARK 465 VAL K 150 REMARK 465 ASP K 151 REMARK 465 ASN K 152 REMARK 465 ALA K 153 REMARK 465 LEU K 154 REMARK 465 GLN K 155 REMARK 465 SER K 156 REMARK 465 GLY K 157 REMARK 465 ASN K 158 REMARK 465 SER K 159 REMARK 465 GLN K 160 REMARK 465 GLU K 161 REMARK 465 SER K 162 REMARK 465 VAL K 163 REMARK 465 THR K 164 REMARK 465 GLU K 165 REMARK 465 GLN K 166 REMARK 465 ASP K 167 REMARK 465 SER K 168 REMARK 465 LYS K 169 REMARK 465 ASP K 170 REMARK 465 SER K 171 REMARK 465 THR K 172 REMARK 465 TYR K 173 REMARK 465 SER K 174 REMARK 465 LEU K 175 REMARK 465 SER K 176 REMARK 465 SER K 177 REMARK 465 THR K 178 REMARK 465 LEU K 179 REMARK 465 THR K 180 REMARK 465 LEU K 181 REMARK 465 SER K 182 REMARK 465 LYS K 183 REMARK 465 ALA K 184 REMARK 465 ASP K 185 REMARK 465 TYR K 186 REMARK 465 GLU K 187 REMARK 465 LYS K 188 REMARK 465 HIS K 189 REMARK 465 LYS K 190 REMARK 465 VAL K 191 REMARK 465 TYR K 192 REMARK 465 ALA K 193 REMARK 465 CYS K 194 REMARK 465 GLU K 195 REMARK 465 VAL K 196 REMARK 465 THR K 197 REMARK 465 HIS K 198 REMARK 465 GLN K 199 REMARK 465 GLY K 200 REMARK 465 LEU K 201 REMARK 465 SER K 202 REMARK 465 SER K 203 REMARK 465 PRO K 204 REMARK 465 VAL K 205 REMARK 465 THR K 206 REMARK 465 LYS K 207 REMARK 465 SER K 208 REMARK 465 PHE K 209 REMARK 465 ASN K 210 REMARK 465 ARG K 211 REMARK 465 GLY K 212 REMARK 465 GLU K 213 REMARK 465 CYS K 214 REMARK 465 ILE L 106 REMARK 465 LYS L 107 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 GLU C1150 C GLU C1150 O -0.163 REMARK 500 SER G 58 CA SER G 58 CB -0.093 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A 30 CA - CB - SG ANGL. DEV. = 6.8 DEGREES REMARK 500 CYS C 30 CA - CB - SG ANGL. DEV. = 12.2 DEGREES REMARK 500 CYS E 30 CA - CB - SG ANGL. DEV. = 9.7 DEGREES REMARK 500 CYS E 284 CA - CB - SG ANGL. DEV. = 7.4 DEGREES REMARK 500 CYS E1047 CA - CB - SG ANGL. DEV. = 10.3 DEGREES REMARK 500 ASN E1154 CB - CA - C ANGL. DEV. = 12.1 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 CYS A 77 56.57 -96.21 REMARK 500 ILE A 304 -61.61 -96.26 REMARK 500 ARG A1127 -120.50 56.89 REMARK 500 ASN A1135 34.09 39.17 REMARK 500 CYS C 77 54.90 -97.36 REMARK 500 THR C 161 -167.90 -128.61 REMARK 500 ILE C 304 -63.16 -97.07 REMARK 500 ARG C 317 54.79 -91.58 REMARK 500 ARG C1127 -120.69 56.73 REMARK 500 ASN C1135 34.70 39.01 REMARK 500 CYS E 77 57.39 -96.64 REMARK 500 THR E 161 -167.18 -127.87 REMARK 500 CYS E 284 141.44 -170.79 REMARK 500 ILE E 304 -62.92 -96.40 REMARK 500 ARG E1127 -118.31 56.29 REMARK 500 ASN E1135 33.81 39.25 REMARK 500 SER G 30 35.49 -94.40 REMARK 500 ILE G 48 -63.93 -107.09 REMARK 500 THR G 83 -169.24 -123.44 REMARK 500 SER H 30 34.21 -93.44 REMARK 500 ILE H 48 -61.47 -106.73 REMARK 500 ASN I 31 44.64 38.48 REMARK 500 ALA I 51 -4.90 66.58 REMARK 500 SER I 52 -15.47 -141.14 REMARK 500 ASP I 82 53.56 -91.67 REMARK 500 SER J 30 34.21 -93.34 REMARK 500 ASN K 31 42.72 38.52 REMARK 500 ALA K 51 -4.97 66.67 REMARK 500 SER K 52 -15.00 -141.77 REMARK 500 ASP K 82 52.55 -92.46 REMARK 500 ASN L 31 43.69 38.61 REMARK 500 ALA L 51 -4.98 66.56 REMARK 500 SER L 52 -15.19 -141.38 REMARK 500 ASP L 82 51.77 -92.31 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 8T1G RELATED DB: PDB REMARK 900 1E11 WITH GROUP 2 INFLUENZA TRIMER REMARK 900 RELATED ID: 8VED RELATED DB: PDB REMARK 900 1E11 WITH GROUP 1 INFLUENZA TRIMER REMARK 900 RELATED ID: 8VEF RELATED DB: PDB REMARK 900 1E08 UCA WITH GROUP 1 INFLUENZA TRIMER REMARK 900 RELATED ID: 8VEE RELATED DB: PDB REMARK 900 1E08 WITH GROUP 2 INFLUENZA TRIMER REMARK 900 RELATED ID: EMD-43169 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF ANTIBODY T5-1E08 IN COMPLEX WITH STABILIZED REMARK 900 H1N1 INFLUENZA HEMAGGLUTININ TRIMER (A/KIEV/1/57) DBREF 8VEB A -6 1227 PDB 8VEB 8VEB -6 1227 DBREF 8VEB C -6 1227 PDB 8VEB 8VEB -6 1227 DBREF 8VEB E -6 1227 PDB 8VEB 8VEB -6 1227 DBREF 8VEB G 1 220 PDB 8VEB 8VEB 1 220 DBREF 8VEB H 1 220 PDB 8VEB 8VEB 1 220 DBREF 8VEB I 1 214 PDB 8VEB 8VEB 1 214 DBREF 8VEB J 1 220 PDB 8VEB 8VEB 1 220 DBREF 8VEB K 1 214 PDB 8VEB 8VEB 1 214 DBREF 8VEB L 1 214 PDB 8VEB 8VEB 1 214 SEQRES 1 A 570 MET LYS ALA LYS LEU LEU ILE LEU LEU CYS ALA LEU SER SEQRES 2 A 570 ALA THR ASP ALA ASP THR ILE CYS ILE GLY TYR HIS ALA SEQRES 3 A 570 ASN ASN SER THR ASP THR VAL ASP THR VAL CYS GLU LYS SEQRES 4 A 570 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 A 570 SER HIS ASN GLY LYS LEU CYS ARG LEU LYS GLY LYS ALA SEQRES 6 A 570 PRO LEU GLN LEU GLY ASN CYS ASN ILE ALA GLY TRP VAL SEQRES 7 A 570 LEU GLY ASN PRO GLU CYS GLU SER LEU LEU SER ASN ARG SEQRES 8 A 570 SER TRP SER TYR ILE ALA GLU THR PRO ASN SER GLU ASN SEQRES 9 A 570 GLY THR CYS PHE PRO GLY ASP PHE ALA ASP TYR GLU GLU SEQRES 10 A 570 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 A 570 PHE GLU ILE PHE PRO LYS GLU ARG SER TRP PRO ASN HIS SEQRES 12 A 570 THR THR ARG GLY VAL THR ALA ALA CYS PRO HIS ALA MET SEQRES 13 A 570 LYS SER SER PHE TYR LYS ASN LEU VAL TRP LEU THR GLU SEQRES 14 A 570 ALA ASN GLY SER TYR PRO ASN LEU SER ARG SER TYR VAL SEQRES 15 A 570 ASN ASN GLN GLU LYS GLU VAL LEU VAL LEU TRP GLY VAL SEQRES 16 A 570 HIS HIS PRO SER ASN ILE GLU ASP GLN ARG THR LEU TYR SEQRES 17 A 570 ARG LYS ASP ASN ALA TYR VAL SER VAL VAL SER SER ASN SEQRES 18 A 570 TYR ASN ARG ARG PHE THR PRO GLU ILE ALA LYS ARG PRO SEQRES 19 A 570 LYS VAL ARG GLY GLN SER GLY ARG ILE ASN TYR TYR TRP SEQRES 20 A 570 THR LEU LEU GLU PRO GLY ASP THR ILE ILE PHE GLU ALA SEQRES 21 A 570 THR GLY ASN LEU ILE ALA PRO TRP TYR ALA PHE ALA LEU SEQRES 22 A 570 SER ARG GLY PRO GLY SER GLY ILE ILE THR SER ASN ALA SEQRES 23 A 570 PRO LEU ASP GLU CYS ASP THR LYS CYS GLN THR PRO GLN SEQRES 24 A 570 GLY ALA ILE ASN SER SER LEU PRO PHE GLN ASN ILE HIS SEQRES 25 A 570 PRO VAL THR ILE GLY GLU CYS PRO LYS TYR VAL ARG SER SEQRES 26 A 570 THR LYS LEU ARG MET VAL THR GLY LEU ARG ASN ILE PRO SEQRES 27 A 570 SER PHE GLN SER ARG GLY LEU PHE GLY ALA ILE ALA GLY SEQRES 28 A 570 PHE ILE GLU GLY GLY TRP THR GLY MET MET ASP GLY TRP SEQRES 29 A 570 TYR GLY TYR HIS HIS GLN ASN GLU GLN GLY SER GLY TYR SEQRES 30 A 570 ALA ALA ASP GLN LYS SER THR GLN ASN ALA ILE ASN CYS SEQRES 31 A 570 ILE THR ASN LYS VAL ASN SER VAL ILE GLU LYS MET ASN SEQRES 32 A 570 THR GLN PHE THR ALA VAL GLY LYS GLU PHE ASN LYS LEU SEQRES 33 A 570 GLU LYS ARG MET GLU ASN LEU ASN LYS LYS VAL ASP ASP SEQRES 34 A 570 GLY PHE LEU ASP ILE TRP THR TYR ASN ALA GLU LEU LEU SEQRES 35 A 570 VAL LEU LEU GLU ASN GLU ARG THR LEU ASP PHE HIS ASP SEQRES 36 A 570 SER ASN VAL LYS ASN LEU TYR GLU LYS VAL LYS ASN GLN SEQRES 37 A 570 LEU ARG ASN ASN ALA LYS GLU LEU GLY ASN GLY CYS PHE SEQRES 38 A 570 GLU PHE TYR HIS LYS CYS ASP ASN GLU CYS MET GLU SER SEQRES 39 A 570 VAL LYS ASN GLY THR TYR ASP TYR PRO LYS TYR SER GLU SEQRES 40 A 570 GLU SER LYS LEU ASN ARG GLU LYS ILE ASP GLY SER GLY SEQRES 41 A 570 TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL SEQRES 42 A 570 ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU SEQRES 43 A 570 GLY SER GLY LEU ASN ASP ILE PHE GLU ALA GLN LYS ILE SEQRES 44 A 570 GLU TRP HIS GLU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 C 570 MET LYS ALA LYS LEU LEU ILE LEU LEU CYS ALA LEU SER SEQRES 2 C 570 ALA THR ASP ALA ASP THR ILE CYS ILE GLY TYR HIS ALA SEQRES 3 C 570 ASN ASN SER THR ASP THR VAL ASP THR VAL CYS GLU LYS SEQRES 4 C 570 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 C 570 SER HIS ASN GLY LYS LEU CYS ARG LEU LYS GLY LYS ALA SEQRES 6 C 570 PRO LEU GLN LEU GLY ASN CYS ASN ILE ALA GLY TRP VAL SEQRES 7 C 570 LEU GLY ASN PRO GLU CYS GLU SER LEU LEU SER ASN ARG SEQRES 8 C 570 SER TRP SER TYR ILE ALA GLU THR PRO ASN SER GLU ASN SEQRES 9 C 570 GLY THR CYS PHE PRO GLY ASP PHE ALA ASP TYR GLU GLU SEQRES 10 C 570 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 C 570 PHE GLU ILE PHE PRO LYS GLU ARG SER TRP PRO ASN HIS SEQRES 12 C 570 THR THR ARG GLY VAL THR ALA ALA CYS PRO HIS ALA MET SEQRES 13 C 570 LYS SER SER PHE TYR LYS ASN LEU VAL TRP LEU THR GLU SEQRES 14 C 570 ALA ASN GLY SER TYR PRO ASN LEU SER ARG SER TYR VAL SEQRES 15 C 570 ASN ASN GLN GLU LYS GLU VAL LEU VAL LEU TRP GLY VAL SEQRES 16 C 570 HIS HIS PRO SER ASN ILE GLU ASP GLN ARG THR LEU TYR SEQRES 17 C 570 ARG LYS ASP ASN ALA TYR VAL SER VAL VAL SER SER ASN SEQRES 18 C 570 TYR ASN ARG ARG PHE THR PRO GLU ILE ALA LYS ARG PRO SEQRES 19 C 570 LYS VAL ARG GLY GLN SER GLY ARG ILE ASN TYR TYR TRP SEQRES 20 C 570 THR LEU LEU GLU PRO GLY ASP THR ILE ILE PHE GLU ALA SEQRES 21 C 570 THR GLY ASN LEU ILE ALA PRO TRP TYR ALA PHE ALA LEU SEQRES 22 C 570 SER ARG GLY PRO GLY SER GLY ILE ILE THR SER ASN ALA SEQRES 23 C 570 PRO LEU ASP GLU CYS ASP THR LYS CYS GLN THR PRO GLN SEQRES 24 C 570 GLY ALA ILE ASN SER SER LEU PRO PHE GLN ASN ILE HIS SEQRES 25 C 570 PRO VAL THR ILE GLY GLU CYS PRO LYS TYR VAL ARG SER SEQRES 26 C 570 THR LYS LEU ARG MET VAL THR GLY LEU ARG ASN ILE PRO SEQRES 27 C 570 SER PHE GLN SER ARG GLY LEU PHE GLY ALA ILE ALA GLY SEQRES 28 C 570 PHE ILE GLU GLY GLY TRP THR GLY MET MET ASP GLY TRP SEQRES 29 C 570 TYR GLY TYR HIS HIS GLN ASN GLU GLN GLY SER GLY TYR SEQRES 30 C 570 ALA ALA ASP GLN LYS SER THR GLN ASN ALA ILE ASN CYS SEQRES 31 C 570 ILE THR ASN LYS VAL ASN SER VAL ILE GLU LYS MET ASN SEQRES 32 C 570 THR GLN PHE THR ALA VAL GLY LYS GLU PHE ASN LYS LEU SEQRES 33 C 570 GLU LYS ARG MET GLU ASN LEU ASN LYS LYS VAL ASP ASP SEQRES 34 C 570 GLY PHE LEU ASP ILE TRP THR TYR ASN ALA GLU LEU LEU SEQRES 35 C 570 VAL LEU LEU GLU ASN GLU ARG THR LEU ASP PHE HIS ASP SEQRES 36 C 570 SER ASN VAL LYS ASN LEU TYR GLU LYS VAL LYS ASN GLN SEQRES 37 C 570 LEU ARG ASN ASN ALA LYS GLU LEU GLY ASN GLY CYS PHE SEQRES 38 C 570 GLU PHE TYR HIS LYS CYS ASP ASN GLU CYS MET GLU SER SEQRES 39 C 570 VAL LYS ASN GLY THR TYR ASP TYR PRO LYS TYR SER GLU SEQRES 40 C 570 GLU SER LYS LEU ASN ARG GLU LYS ILE ASP GLY SER GLY SEQRES 41 C 570 TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL SEQRES 42 C 570 ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU SEQRES 43 C 570 GLY SER GLY LEU ASN ASP ILE PHE GLU ALA GLN LYS ILE SEQRES 44 C 570 GLU TRP HIS GLU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 E 570 MET LYS ALA LYS LEU LEU ILE LEU LEU CYS ALA LEU SER SEQRES 2 E 570 ALA THR ASP ALA ASP THR ILE CYS ILE GLY TYR HIS ALA SEQRES 3 E 570 ASN ASN SER THR ASP THR VAL ASP THR VAL CYS GLU LYS SEQRES 4 E 570 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 E 570 SER HIS ASN GLY LYS LEU CYS ARG LEU LYS GLY LYS ALA SEQRES 6 E 570 PRO LEU GLN LEU GLY ASN CYS ASN ILE ALA GLY TRP VAL SEQRES 7 E 570 LEU GLY ASN PRO GLU CYS GLU SER LEU LEU SER ASN ARG SEQRES 8 E 570 SER TRP SER TYR ILE ALA GLU THR PRO ASN SER GLU ASN SEQRES 9 E 570 GLY THR CYS PHE PRO GLY ASP PHE ALA ASP TYR GLU GLU SEQRES 10 E 570 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 E 570 PHE GLU ILE PHE PRO LYS GLU ARG SER TRP PRO ASN HIS SEQRES 12 E 570 THR THR ARG GLY VAL THR ALA ALA CYS PRO HIS ALA MET SEQRES 13 E 570 LYS SER SER PHE TYR LYS ASN LEU VAL TRP LEU THR GLU SEQRES 14 E 570 ALA ASN GLY SER TYR PRO ASN LEU SER ARG SER TYR VAL SEQRES 15 E 570 ASN ASN GLN GLU LYS GLU VAL LEU VAL LEU TRP GLY VAL SEQRES 16 E 570 HIS HIS PRO SER ASN ILE GLU ASP GLN ARG THR LEU TYR SEQRES 17 E 570 ARG LYS ASP ASN ALA TYR VAL SER VAL VAL SER SER ASN SEQRES 18 E 570 TYR ASN ARG ARG PHE THR PRO GLU ILE ALA LYS ARG PRO SEQRES 19 E 570 LYS VAL ARG GLY GLN SER GLY ARG ILE ASN TYR TYR TRP SEQRES 20 E 570 THR LEU LEU GLU PRO GLY ASP THR ILE ILE PHE GLU ALA SEQRES 21 E 570 THR GLY ASN LEU ILE ALA PRO TRP TYR ALA PHE ALA LEU SEQRES 22 E 570 SER ARG GLY PRO GLY SER GLY ILE ILE THR SER ASN ALA SEQRES 23 E 570 PRO LEU ASP GLU CYS ASP THR LYS CYS GLN THR PRO GLN SEQRES 24 E 570 GLY ALA ILE ASN SER SER LEU PRO PHE GLN ASN ILE HIS SEQRES 25 E 570 PRO VAL THR ILE GLY GLU CYS PRO LYS TYR VAL ARG SER SEQRES 26 E 570 THR LYS LEU ARG MET VAL THR GLY LEU ARG ASN ILE PRO SEQRES 27 E 570 SER PHE GLN SER ARG GLY LEU PHE GLY ALA ILE ALA GLY SEQRES 28 E 570 PHE ILE GLU GLY GLY TRP THR GLY MET MET ASP GLY TRP SEQRES 29 E 570 TYR GLY TYR HIS HIS GLN ASN GLU GLN GLY SER GLY TYR SEQRES 30 E 570 ALA ALA ASP GLN LYS SER THR GLN ASN ALA ILE ASN CYS SEQRES 31 E 570 ILE THR ASN LYS VAL ASN SER VAL ILE GLU LYS MET ASN SEQRES 32 E 570 THR GLN PHE THR ALA VAL GLY LYS GLU PHE ASN LYS LEU SEQRES 33 E 570 GLU LYS ARG MET GLU ASN LEU ASN LYS LYS VAL ASP ASP SEQRES 34 E 570 GLY PHE LEU ASP ILE TRP THR TYR ASN ALA GLU LEU LEU SEQRES 35 E 570 VAL LEU LEU GLU ASN GLU ARG THR LEU ASP PHE HIS ASP SEQRES 36 E 570 SER ASN VAL LYS ASN LEU TYR GLU LYS VAL LYS ASN GLN SEQRES 37 E 570 LEU ARG ASN ASN ALA LYS GLU LEU GLY ASN GLY CYS PHE SEQRES 38 E 570 GLU PHE TYR HIS LYS CYS ASP ASN GLU CYS MET GLU SER SEQRES 39 E 570 VAL LYS ASN GLY THR TYR ASP TYR PRO LYS TYR SER GLU SEQRES 40 E 570 GLU SER LYS LEU ASN ARG GLU LYS ILE ASP GLY SER GLY SEQRES 41 E 570 TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL SEQRES 42 E 570 ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU SEQRES 43 E 570 GLY SER GLY LEU ASN ASP ILE PHE GLU ALA GLN LYS ILE SEQRES 44 E 570 GLU TRP HIS GLU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 G 238 GLN VAL GLN LEU LEU GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 G 238 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 G 238 GLY SER VAL SER ARG GLY GLY TYR TYR TRP THR TRP ILE SEQRES 4 G 238 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE ALA TYR SEQRES 5 G 238 VAL THR TYR SER GLY ASP THR SER TYR ASN PRO SER LEU SEQRES 6 G 238 ARG GLY ARG VAL THR ILE SER LEU GLU THR SER MET ASN SEQRES 7 G 238 GLN PHE SER LEU LYS VAL THR SER VAL THR VAL ALA ASP SEQRES 8 G 238 THR ALA LEU TYR PHE CYS ALA ARG VAL PRO PHE TYR TYR SEQRES 9 G 238 ASP THR ARG GLY VAL PHE TYR GLY ASN ALA GLU GLY GLY SEQRES 10 G 238 PHE GLU ILE TRP GLY GLN GLY THR MET ALA THR VAL SER SEQRES 11 G 238 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 12 G 238 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 13 G 238 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 G 238 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 G 238 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 G 238 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 G 238 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 G 238 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 19 G 238 ASP LYS THR HIS SEQRES 1 H 238 GLN VAL GLN LEU LEU GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 H 238 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 H 238 GLY SER VAL SER ARG GLY GLY TYR TYR TRP THR TRP ILE SEQRES 4 H 238 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE ALA TYR SEQRES 5 H 238 VAL THR TYR SER GLY ASP THR SER TYR ASN PRO SER LEU SEQRES 6 H 238 ARG GLY ARG VAL THR ILE SER LEU GLU THR SER MET ASN SEQRES 7 H 238 GLN PHE SER LEU LYS VAL THR SER VAL THR VAL ALA ASP SEQRES 8 H 238 THR ALA LEU TYR PHE CYS ALA ARG VAL PRO PHE TYR TYR SEQRES 9 H 238 ASP THR ARG GLY VAL PHE TYR GLY ASN ALA GLU GLY GLY SEQRES 10 H 238 PHE GLU ILE TRP GLY GLN GLY THR MET ALA THR VAL SER SEQRES 11 H 238 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 12 H 238 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 13 H 238 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 H 238 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 H 238 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 H 238 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 H 238 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 H 238 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 19 H 238 ASP LYS THR HIS SEQRES 1 I 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 I 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 I 214 GLN GLY ILE THR ASN ASP LEU ARG TRP TYR GLN GLN LYS SEQRES 4 I 214 PRO GLY LYS ALA PRO GLN CYS LEU ILE SER SER ALA SER SEQRES 5 I 214 ARG LEU GLN SER GLY VAL SER SER ARG PHE SER GLY SER SEQRES 6 I 214 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 I 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS LEU GLN HIS SEQRES 8 I 214 ASN SER TYR GLN TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 I 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 I 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 I 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 I 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 I 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 I 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 I 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 I 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 I 214 PHE ASN ARG GLY GLU CYS SEQRES 1 J 238 GLN VAL GLN LEU LEU GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 J 238 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 J 238 GLY SER VAL SER ARG GLY GLY TYR TYR TRP THR TRP ILE SEQRES 4 J 238 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE ALA TYR SEQRES 5 J 238 VAL THR TYR SER GLY ASP THR SER TYR ASN PRO SER LEU SEQRES 6 J 238 ARG GLY ARG VAL THR ILE SER LEU GLU THR SER MET ASN SEQRES 7 J 238 GLN PHE SER LEU LYS VAL THR SER VAL THR VAL ALA ASP SEQRES 8 J 238 THR ALA LEU TYR PHE CYS ALA ARG VAL PRO PHE TYR TYR SEQRES 9 J 238 ASP THR ARG GLY VAL PHE TYR GLY ASN ALA GLU GLY GLY SEQRES 10 J 238 PHE GLU ILE TRP GLY GLN GLY THR MET ALA THR VAL SER SEQRES 11 J 238 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 12 J 238 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 13 J 238 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 J 238 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 J 238 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 J 238 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 J 238 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 J 238 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 19 J 238 ASP LYS THR HIS SEQRES 1 K 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 K 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 K 214 GLN GLY ILE THR ASN ASP LEU ARG TRP TYR GLN GLN LYS SEQRES 4 K 214 PRO GLY LYS ALA PRO GLN CYS LEU ILE SER SER ALA SER SEQRES 5 K 214 ARG LEU GLN SER GLY VAL SER SER ARG PHE SER GLY SER SEQRES 6 K 214 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 K 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS LEU GLN HIS SEQRES 8 K 214 ASN SER TYR GLN TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 K 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 K 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 K 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 K 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 K 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 K 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 K 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 K 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 K 214 PHE ASN ARG GLY GLU CYS SEQRES 1 L 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 214 GLN GLY ILE THR ASN ASP LEU ARG TRP TYR GLN GLN LYS SEQRES 4 L 214 PRO GLY LYS ALA PRO GLN CYS LEU ILE SER SER ALA SER SEQRES 5 L 214 ARG LEU GLN SER GLY VAL SER SER ARG PHE SER GLY SER SEQRES 6 L 214 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS LEU GLN HIS SEQRES 8 L 214 ASN SER TYR GLN TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 L 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 L 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 L 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 L 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 L 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 L 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 L 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 L 214 PHE ASN ARG GLY GLU CYS HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET BMA N 3 11 HET MAN N 4 11 HET MAN N 5 11 HET MAN N 6 11 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET MAN P 4 11 HET MAN P 5 11 HET MAN P 6 11 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET BMA R 3 11 HET MAN R 4 11 HET MAN R 5 11 HET MAN R 6 11 HET NAG A2001 14 HET NAG A2002 14 HET NAG A2003 14 HET NAG A2004 14 HET NAG C2001 14 HET NAG C2002 14 HET NAG C2003 14 HET NAG C2004 14 HET NAG E2001 14 HET NAG E2002 14 HET NAG E2003 14 HET NAG E2004 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 24(C8 H15 N O6) FORMUL 11 BMA 3(C6 H12 O6) FORMUL 11 MAN 9(C6 H12 O6) HELIX 1 AA1 ASN A 66 GLY A 73 1 8 HELIX 2 AA2 ASP A 107 LEU A 115 1 9 HELIX 3 AA3 ASN A 193 TYR A 201 1 9 HELIX 4 AA4 ASP A 1037 MET A 1059 1 23 HELIX 5 AA5 GLU A 1074 ARG A 1127 1 54 HELIX 6 AA6 ASP A 1145 LYS A 1153 1 9 HELIX 7 AA7 TYR A 1162 ILE A 1173 1 12 HELIX 8 AA8 ASN C 66 GLY C 73 1 8 HELIX 9 AA9 ASP C 107 SER C 117 1 11 HELIX 10 AB1 ASN C 193 ARG C 202 1 10 HELIX 11 AB2 ASP C 1037 MET C 1059 1 23 HELIX 12 AB3 GLU C 1074 ARG C 1127 1 54 HELIX 13 AB4 ASP C 1145 ASN C 1154 1 10 HELIX 14 AB5 TYR C 1162 ILE C 1173 1 12 HELIX 15 AB6 ASN E 66 GLY E 73 1 8 HELIX 16 AB7 ASP E 107 LEU E 115 1 9 HELIX 17 AB8 ASN E 193 ARG E 202 1 10 HELIX 18 AB9 ASP E 1037 MET E 1059 1 23 HELIX 19 AC1 GLU E 1074 ARG E 1127 1 54 HELIX 20 AC2 ASP E 1145 ASN E 1154 1 10 HELIX 21 AC3 TYR E 1162 ILE E 1173 1 12 HELIX 22 AC4 PRO G 61 ARG G 64 5 4 HELIX 23 AC5 THR G 83 THR G 87 5 5 HELIX 24 AC6 PRO H 61 ARG H 64 5 4 HELIX 25 AC7 PRO J 61 ARG J 64 5 4 SHEET 1 AA1 5 SER A1032 ALA A1036 0 SHEET 2 AA1 5 TYR A1022 GLN A1027 -1 N TYR A1024 O ALA A1035 SHEET 3 AA1 5 THR A 12 TYR A 17 -1 N THR A 12 O GLN A1027 SHEET 4 AA1 5 CYS A1137 PHE A1140 -1 O PHE A1138 N ILE A 13 SHEET 5 AA1 5 ALA A1130 GLU A1132 -1 N LYS A1131 O GLU A1139 SHEET 1 AA2 2 ASP A 24 ASP A 27 0 SHEET 2 AA2 2 LYS A 32 VAL A 36 -1 O VAL A 36 N ASP A 24 SHEET 1 AA3 2 SER A 39 ASN A 41 0 SHEET 2 AA3 2 ARG A 322 VAL A 324 -1 O MET A 323 N VAL A 40 SHEET 1 AA4 3 LEU A 43 GLU A 44 0 SHEET 2 AA4 3 PHE A 301 GLN A 302 1 O PHE A 301 N GLU A 44 SHEET 3 AA4 3 LYS A 314 TYR A 315 1 O LYS A 314 N GLN A 302 SHEET 1 AA5 3 LEU A 60 GLY A 63 0 SHEET 2 AA5 3 ILE A 89 GLU A 91 1 O ALA A 90 N LEU A 62 SHEET 3 AA5 3 ILE A 274 THR A 276 1 O ILE A 275 N ILE A 89 SHEET 1 AA6 6 ARG A 84 SER A 85 0 SHEET 2 AA6 6 VAL A 118 PHE A 121 -1 O PHE A 121 N ARG A 84 SHEET 3 AA6 6 TYR A 262 ARG A 268 -1 O SER A 267 N SER A 119 SHEET 4 AA6 6 GLU A 181 HIS A 190 -1 N LEU A 183 O PHE A 264 SHEET 5 AA6 6 LEU A 257 PRO A 260 -1 O ILE A 258 N GLY A 187 SHEET 6 AA6 6 LEU A 157 TRP A 159 -1 N VAL A 158 O ALA A 259 SHEET 1 AA7 4 ARG A 123 GLU A 125 0 SHEET 2 AA7 4 TYR A 262 ARG A 268 -1 O ALA A 263 N PHE A 124 SHEET 3 AA7 4 GLU A 181 HIS A 190 -1 N LEU A 183 O PHE A 264 SHEET 4 AA7 4 ARG A 235 LEU A 243 -1 O ARG A 235 N HIS A 190 SHEET 1 AA8 2 THR A 142 PRO A 146 0 SHEET 2 AA8 2 SER A 151 SER A 152 -1 O SER A 152 N CYS A 145 SHEET 1 AA9 4 LEU A 170 VAL A 175 0 SHEET 2 AA9 4 THR A 248 ALA A 253 -1 O ILE A 249 N TYR A 174 SHEET 3 AA9 4 VAL A 208 VAL A 211 -1 N SER A 209 O GLU A 252 SHEET 4 AA9 4 ASN A 216 PHE A 219 -1 O PHE A 219 N VAL A 208 SHEET 1 AB1 3 GLY A 293 ILE A 295 0 SHEET 2 AB1 3 CYS A 288 THR A 290 -1 N THR A 290 O GLY A 293 SHEET 3 AB1 3 ILE A 309 GLY A 310 -1 O ILE A 309 N GLN A 289 SHEET 1 AB2 5 SER C1032 ALA C1036 0 SHEET 2 AB2 5 TYR C1022 GLN C1027 -1 N TYR C1024 O ALA C1035 SHEET 3 AB2 5 THR C 12 TYR C 17 -1 N THR C 12 O GLN C1027 SHEET 4 AB2 5 CYS C1137 PHE C1140 -1 O PHE C1138 N ILE C 13 SHEET 5 AB2 5 ALA C1130 GLU C1132 -1 N LYS C1131 O GLU C1139 SHEET 1 AB3 2 ASP C 24 ASP C 27 0 SHEET 2 AB3 2 LYS C 32 VAL C 36 -1 O VAL C 36 N ASP C 24 SHEET 1 AB4 2 SER C 39 ASN C 41 0 SHEET 2 AB4 2 ARG C 322 VAL C 324 -1 O MET C 323 N VAL C 40 SHEET 1 AB5 3 LEU C 43 GLU C 44 0 SHEET 2 AB5 3 PHE C 301 GLN C 302 1 O PHE C 301 N GLU C 44 SHEET 3 AB5 3 LYS C 314 TYR C 315 1 O LYS C 314 N GLN C 302 SHEET 1 AB6 2 LEU C 51 LEU C 54 0 SHEET 2 AB6 2 LEU C 281 THR C 286 1 O ASP C 282 N LEU C 51 SHEET 1 AB7 3 LEU C 60 GLY C 63 0 SHEET 2 AB7 3 ILE C 89 GLU C 91 1 O ALA C 90 N LEU C 62 SHEET 3 AB7 3 ILE C 274 THR C 276 1 O ILE C 275 N ILE C 89 SHEET 1 AB8 6 ARG C 84 SER C 85 0 SHEET 2 AB8 6 VAL C 118 GLU C 125 -1 O PHE C 121 N ARG C 84 SHEET 3 AB8 6 TYR C 262 ARG C 268 -1 O SER C 267 N SER C 119 SHEET 4 AB8 6 GLU C 181 HIS C 190 -1 N GLU C 181 O LEU C 266 SHEET 5 AB8 6 LEU C 257 PRO C 260 -1 O ILE C 258 N GLY C 187 SHEET 6 AB8 6 LEU C 157 TRP C 159 -1 N VAL C 158 O ALA C 259 SHEET 1 AB9 5 ARG C 84 SER C 85 0 SHEET 2 AB9 5 VAL C 118 GLU C 125 -1 O PHE C 121 N ARG C 84 SHEET 3 AB9 5 TYR C 262 ARG C 268 -1 O SER C 267 N SER C 119 SHEET 4 AB9 5 GLU C 181 HIS C 190 -1 N GLU C 181 O LEU C 266 SHEET 5 AB9 5 ARG C 235 LEU C 243 -1 O ARG C 235 N HIS C 190 SHEET 1 AC1 2 THR C 142 PRO C 146 0 SHEET 2 AC1 2 SER C 151 SER C 152 -1 O SER C 152 N CYS C 145 SHEET 1 AC2 4 LEU C 170 VAL C 175 0 SHEET 2 AC2 4 THR C 248 ALA C 253 -1 O ILE C 249 N TYR C 174 SHEET 3 AC2 4 VAL C 208 VAL C 211 -1 N SER C 209 O GLU C 252 SHEET 4 AC2 4 ASN C 216 PHE C 219 -1 O PHE C 219 N VAL C 208 SHEET 1 AC3 3 ALA C 294 ILE C 295 0 SHEET 2 AC3 3 CYS C 288 GLN C 289 -1 N CYS C 288 O ILE C 295 SHEET 3 AC3 3 ILE C 309 GLY C 310 -1 O ILE C 309 N GLN C 289 SHEET 1 AC4 5 SER E1032 ALA E1036 0 SHEET 2 AC4 5 TYR E1022 GLN E1027 -1 N TYR E1024 O ALA E1035 SHEET 3 AC4 5 THR E 12 TYR E 17 -1 N THR E 12 O GLN E1027 SHEET 4 AC4 5 CYS E1137 PHE E1140 -1 O PHE E1138 N ILE E 13 SHEET 5 AC4 5 ALA E1130 GLU E1132 -1 N LYS E1131 O GLU E1139 SHEET 1 AC5 2 ASP E 24 ASP E 27 0 SHEET 2 AC5 2 LYS E 32 VAL E 36 -1 O VAL E 36 N ASP E 24 SHEET 1 AC6 2 SER E 39 ASN E 41 0 SHEET 2 AC6 2 ARG E 322 VAL E 324 -1 O MET E 323 N VAL E 40 SHEET 1 AC7 3 LEU E 43 GLU E 44 0 SHEET 2 AC7 3 PHE E 301 GLN E 302 1 O PHE E 301 N GLU E 44 SHEET 3 AC7 3 LYS E 314 TYR E 315 1 O LYS E 314 N GLN E 302 SHEET 1 AC8 2 LEU E 51 LEU E 54 0 SHEET 2 AC8 2 LEU E 281 THR E 286 1 O ASP E 282 N LEU E 51 SHEET 1 AC9 3 LEU E 60 GLY E 63 0 SHEET 2 AC9 3 ILE E 89 GLU E 91 1 O ALA E 90 N LEU E 62 SHEET 3 AC9 3 ILE E 274 THR E 276 1 O ILE E 275 N ILE E 89 SHEET 1 AD1 5 VAL E 118 SER E 120 0 SHEET 2 AD1 5 TYR E 262 ARG E 268 -1 O SER E 267 N SER E 119 SHEET 3 AD1 5 GLU E 181 HIS E 190 -1 N GLU E 181 O LEU E 266 SHEET 4 AD1 5 LEU E 257 PRO E 260 -1 O ILE E 258 N GLY E 187 SHEET 5 AD1 5 LEU E 157 TRP E 159 -1 N VAL E 158 O ALA E 259 SHEET 1 AD2 4 ARG E 123 GLU E 125 0 SHEET 2 AD2 4 TYR E 262 ARG E 268 -1 O ALA E 263 N PHE E 124 SHEET 3 AD2 4 GLU E 181 HIS E 190 -1 N GLU E 181 O LEU E 266 SHEET 4 AD2 4 ARG E 235 LEU E 243 -1 O ARG E 235 N HIS E 190 SHEET 1 AD3 2 THR E 142 PRO E 146 0 SHEET 2 AD3 2 SER E 151 SER E 152 -1 O SER E 152 N CYS E 145 SHEET 1 AD4 4 LEU E 170 VAL E 175 0 SHEET 2 AD4 4 THR E 248 ALA E 253 -1 O PHE E 251 N ARG E 172 SHEET 3 AD4 4 VAL E 208 VAL E 211 -1 N SER E 209 O GLU E 252 SHEET 4 AD4 4 ASN E 216 PHE E 219 -1 O PHE E 219 N VAL E 208 SHEET 1 AD5 3 ALA E 294 ILE E 295 0 SHEET 2 AD5 3 CYS E 288 GLN E 289 -1 N CYS E 288 O ILE E 295 SHEET 3 AD5 3 ILE E 309 GLY E 310 -1 O ILE E 309 N GLN E 289 SHEET 1 AD6 4 GLN G 3 SER G 7 0 SHEET 2 AD6 4 THR G 17 SER G 25 -1 O SER G 25 N GLN G 3 SHEET 3 AD6 4 GLN G 77 THR G 82A-1 O VAL G 82 N LEU G 18 SHEET 4 AD6 4 VAL G 67 GLU G 72 -1 N THR G 68 O LYS G 81 SHEET 1 AD7 5 THR G 57 TYR G 59 0 SHEET 2 AD7 5 LEU G 45 VAL G 51 -1 N TYR G 50 O SER G 58 SHEET 3 AD7 5 TYR G 34 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 4 AD7 5 ALA G 88 PRO G 96 -1 O PHE G 91 N ILE G 37 SHEET 5 AD7 5 ILE G 102 TRP G 103 -1 O ILE G 102 N ARG G 94 SHEET 1 AD8 5 THR G 57 TYR G 59 0 SHEET 2 AD8 5 LEU G 45 VAL G 51 -1 N TYR G 50 O SER G 58 SHEET 3 AD8 5 TYR G 34 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 4 AD8 5 ALA G 88 PRO G 96 -1 O PHE G 91 N ILE G 37 SHEET 5 AD8 5 THR G 107 ALA G 109 -1 O THR G 107 N TYR G 90 SHEET 1 AD9 4 GLN H 3 SER H 7 0 SHEET 2 AD9 4 THR H 17 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AD9 4 GLN H 77 THR H 82A-1 O VAL H 82 N LEU H 18 SHEET 4 AD9 4 VAL H 67 GLU H 72 -1 N SER H 70 O SER H 79 SHEET 1 AE1 5 THR H 57 TYR H 59 0 SHEET 2 AE1 5 LEU H 45 VAL H 51 -1 N TYR H 50 O SER H 58 SHEET 3 AE1 5 TYR H 34 GLN H 39 -1 N ARG H 38 O GLU H 46 SHEET 4 AE1 5 LEU H 89 PRO H 96 -1 O PHE H 91 N ILE H 37 SHEET 5 AE1 5 ILE H 102 TRP H 103 -1 O ILE H 102 N ARG H 94 SHEET 1 AE2 5 THR H 57 TYR H 59 0 SHEET 2 AE2 5 LEU H 45 VAL H 51 -1 N TYR H 50 O SER H 58 SHEET 3 AE2 5 TYR H 34 GLN H 39 -1 N ARG H 38 O GLU H 46 SHEET 4 AE2 5 LEU H 89 PRO H 96 -1 O PHE H 91 N ILE H 37 SHEET 5 AE2 5 THR H 107 MET H 108 -1 O THR H 107 N TYR H 90 SHEET 1 AE3 3 MET I 4 SER I 7 0 SHEET 2 AE3 3 VAL I 19 ILE I 29 -1 O ARG I 24 N THR I 5 SHEET 3 AE3 3 PHE I 62 ILE I 75 -1 O LEU I 73 N ILE I 21 SHEET 1 AE4 6 SER I 10 SER I 12 0 SHEET 2 AE4 6 THR I 102 GLU I 105 1 O LYS I 103 N LEU I 11 SHEET 3 AE4 6 THR I 85 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AE4 6 LEU I 33 GLN I 38 -1 N ARG I 34 O LEU I 89 SHEET 5 AE4 6 GLN I 45 SER I 49 -1 O ILE I 48 N TRP I 35 SHEET 6 AE4 6 ARG I 53 LEU I 54 -1 O ARG I 53 N SER I 49 SHEET 1 AE5 4 GLN J 3 SER J 7 0 SHEET 2 AE5 4 LEU J 18 SER J 25 -1 O SER J 25 N GLN J 3 SHEET 3 AE5 4 GLN J 77 VAL J 82 -1 O VAL J 82 N LEU J 18 SHEET 4 AE5 4 VAL J 67 GLU J 72 -1 N THR J 68 O LYS J 81 SHEET 1 AE6 5 THR J 57 TYR J 59 0 SHEET 2 AE6 5 LEU J 45 VAL J 51 -1 N TYR J 50 O SER J 58 SHEET 3 AE6 5 TYR J 34 GLN J 39 -1 N ARG J 38 O GLU J 46 SHEET 4 AE6 5 LEU J 89 PRO J 96 -1 O PHE J 91 N ILE J 37 SHEET 5 AE6 5 ILE J 102 TRP J 103 -1 O ILE J 102 N ARG J 94 SHEET 1 AE7 5 THR J 57 TYR J 59 0 SHEET 2 AE7 5 LEU J 45 VAL J 51 -1 N TYR J 50 O SER J 58 SHEET 3 AE7 5 TYR J 34 GLN J 39 -1 N ARG J 38 O GLU J 46 SHEET 4 AE7 5 LEU J 89 PRO J 96 -1 O PHE J 91 N ILE J 37 SHEET 5 AE7 5 THR J 107 MET J 108 -1 O THR J 107 N TYR J 90 SHEET 1 AE8 3 MET K 4 SER K 7 0 SHEET 2 AE8 3 VAL K 19 ILE K 29 -1 O ARG K 24 N THR K 5 SHEET 3 AE8 3 PHE K 62 ILE K 75 -1 O LEU K 73 N ILE K 21 SHEET 1 AE9 6 SER K 10 SER K 12 0 SHEET 2 AE9 6 THR K 102 GLU K 105 1 O LYS K 103 N LEU K 11 SHEET 3 AE9 6 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AE9 6 LEU K 33 GLN K 38 -1 N ARG K 34 O LEU K 89 SHEET 5 AE9 6 GLN K 45 SER K 49 -1 O LEU K 47 N TRP K 35 SHEET 6 AE9 6 ARG K 53 LEU K 54 -1 O ARG K 53 N SER K 49 SHEET 1 AF1 3 MET L 4 SER L 7 0 SHEET 2 AF1 3 VAL L 19 ILE L 29 -1 O ARG L 24 N THR L 5 SHEET 3 AF1 3 PHE L 62 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 1 AF2 6 SER L 10 SER L 12 0 SHEET 2 AF2 6 THR L 102 GLU L 105 1 O LYS L 103 N LEU L 11 SHEET 3 AF2 6 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AF2 6 LEU L 33 GLN L 38 -1 N ARG L 34 O LEU L 89 SHEET 5 AF2 6 GLN L 45 SER L 49 -1 O LEU L 47 N TRP L 35 SHEET 6 AF2 6 ARG L 53 LEU L 54 -1 O ARG L 53 N SER L 49 SSBOND 1 CYS A 14 CYS A 1137 1555 1555 2.03 SSBOND 2 CYS A 30 CYS C 1047 1555 1555 2.07 SSBOND 3 CYS A 52 CYS A 284 1555 1555 2.03 SSBOND 4 CYS A 65 CYS A 77 1555 1555 2.02 SSBOND 5 CYS A 100 CYS A 145 1555 1555 2.03 SSBOND 6 CYS A 288 CYS A 312 1555 1555 2.02 SSBOND 7 CYS A 1047 CYS E 30 1555 1555 2.04 SSBOND 8 CYS A 1144 CYS A 1148 1555 1555 2.05 SSBOND 9 CYS C 14 CYS C 1137 1555 1555 2.03 SSBOND 10 CYS C 30 CYS E 1047 1555 1555 2.08 SSBOND 11 CYS C 52 CYS C 284 1555 1555 2.03 SSBOND 12 CYS C 65 CYS C 77 1555 1555 2.02 SSBOND 13 CYS C 100 CYS C 145 1555 1555 2.03 SSBOND 14 CYS C 288 CYS C 312 1555 1555 2.03 SSBOND 15 CYS C 1144 CYS C 1148 1555 1555 2.07 SSBOND 16 CYS E 14 CYS E 1137 1555 1555 2.03 SSBOND 17 CYS E 52 CYS E 284 1555 1555 2.04 SSBOND 18 CYS E 65 CYS E 77 1555 1555 2.03 SSBOND 19 CYS E 100 CYS E 145 1555 1555 2.03 SSBOND 20 CYS E 288 CYS E 312 1555 1555 2.02 SSBOND 21 CYS E 1144 CYS E 1148 1555 1555 2.06 SSBOND 22 CYS G 22 CYS G 92 1555 1555 2.03 SSBOND 23 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 24 CYS I 23 CYS I 88 1555 1555 2.04 SSBOND 25 CYS J 22 CYS J 92 1555 1555 2.03 SSBOND 26 CYS K 23 CYS K 88 1555 1555 2.04 SSBOND 27 CYS L 23 CYS L 88 1555 1555 2.04 LINK ND2 ASN A 21 C1 NAG A2002 1555 1555 1.44 LINK ND2 ASN A 33 C1 NAG A2003 1555 1555 1.44 LINK ND2 ASN A 83 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN A 97 C1 NAG A2001 1555 1555 1.44 LINK ND2 ASN A 169 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN A1154 C1 NAG A2004 1555 1555 1.48 LINK ND2 ASN C 21 C1 NAG C2002 1555 1555 1.44 LINK ND2 ASN C 33 C1 NAG C2003 1555 1555 1.44 LINK ND2 ASN C 83 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN C 97 C1 NAG C2001 1555 1555 1.44 LINK ND2 ASN C 169 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN C1154 C1 NAG C2004 1555 1555 1.48 LINK ND2 ASN E 21 C1 NAG E2002 1555 1555 1.44 LINK ND2 ASN E 33 C1 NAG E2003 1555 1555 1.44 LINK ND2 ASN E 83 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN E 97 C1 NAG E2001 1555 1555 1.44 LINK ND2 ASN E 169 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN E1154 C1 NAG E2004 1555 1555 1.48 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.45 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG N 2 C1 BMA N 3 1555 1555 1.45 LINK O6 BMA N 3 C1 MAN N 4 1555 1555 1.44 LINK O3 BMA N 3 C1 MAN N 6 1555 1555 1.44 LINK O6 MAN N 4 C1 MAN N 5 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.45 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.45 LINK O6 BMA P 3 C1 MAN P 4 1555 1555 1.44 LINK O3 BMA P 3 C1 MAN P 6 1555 1555 1.44 LINK O6 MAN P 4 C1 MAN P 5 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG R 2 C1 BMA R 3 1555 1555 1.45 LINK O6 BMA R 3 C1 MAN R 4 1555 1555 1.44 LINK O3 BMA R 3 C1 MAN R 6 1555 1555 1.44 LINK O6 MAN R 4 C1 MAN R 5 1555 1555 1.44 CISPEP 1 SER I 7 PRO I 8 0 -5.21 CISPEP 2 SER K 7 PRO K 8 0 -4.28 CISPEP 3 SER L 7 PRO L 8 0 -5.97 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000