HEADER IMMUNE SYSTEM/VIRAL PROTEIN 18-DEC-23 8VED TITLE CRYO-EM STRUCTURE OF ANTIBODY T5-1E11 IN COMPLEX WITH STABILIZED H1N1 TITLE 2 INFLUENZA HEMAGGLUTININ TRIMER (A/KIEV/1/57) COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: A, C, E; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: T5-1E11 FAB HEAVY CHAIN; COMPND 7 CHAIN: H, G, J; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: T5-1E11 FAB LIGHT CHAIN; COMPND 11 CHAIN: L, I, K; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 11320; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_TAXID: 9606; SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS BROADLY NEUTRALIZING ANTIBODY, GROUP 1, INFLUENZA, CRYO-EM, FAB, KEYWDS 2 HEMAGGLUTININ, TRIMER, SPIKE, IMMUNE SYSTEM, VIRAL PROTEIN, IMMUNE KEYWDS 3 SYSTEM-VIRAL PROTEIN COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.CERUTTI,L.SHAPIRO REVDAT 1 19-MAR-25 8VED 0 JRNL AUTH G.CERUTTI,L.SHAPIRO JRNL TITL CRYO-EM STRUCTURE OF ANTIBODY T5-1E11 IN COMPLEX WITH JRNL TITL 2 STABILIZED H1N1 INFLUENZA HEMAGGLUTININ TRIMER (A/KIEV/1/57) JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.98 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.980 REMARK 3 NUMBER OF PARTICLES : 463321 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8VED COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 30-DEC-23. REMARK 100 THE DEPOSITION ID IS D_1000276610. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : ANTIBODY T5-1E11 FAB IN COMPLEX REMARK 245 WITH INFLUENZA HEMAGGLUTININ REMARK 245 TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.20 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5121.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, H, L, C, G, I, E, J, K, M, REMARK 350 AND CHAINS: N, O, P, Q, R, S, T, U REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -6 REMARK 465 LYS A -5 REMARK 465 ALA A -4 REMARK 465 LYS A -3 REMARK 465 LEU A -2 REMARK 465 LEU A -1 REMARK 465 ILE A 0 REMARK 465 LEU A 1 REMARK 465 LEU A 2 REMARK 465 CYS A 3 REMARK 465 ALA A 4 REMARK 465 LEU A 5 REMARK 465 SER A 6 REMARK 465 ALA A 7 REMARK 465 THR A 8 REMARK 465 ASP A 9 REMARK 465 ALA A 10 REMARK 465 PHE A 333 REMARK 465 GLN A 334 REMARK 465 SER A 335 REMARK 465 ARG A 336 REMARK 465 GLY A 1001 REMARK 465 LEU A 1002 REMARK 465 PHE A 1003 REMARK 465 GLY A 1004 REMARK 465 ASP A 1174 REMARK 465 GLY A 1175 REMARK 465 SER A 1176 REMARK 465 GLY A 1177 REMARK 465 TYR A 1178 REMARK 465 ILE A 1179 REMARK 465 PRO A 1180 REMARK 465 GLU A 1181 REMARK 465 ALA A 1182 REMARK 465 PRO A 1183 REMARK 465 ARG A 1184 REMARK 465 ASP A 1185 REMARK 465 GLY A 1186 REMARK 465 GLN A 1187 REMARK 465 ALA A 1188 REMARK 465 TYR A 1189 REMARK 465 VAL A 1190 REMARK 465 ARG A 1191 REMARK 465 LYS A 1192 REMARK 465 ASP A 1193 REMARK 465 GLY A 1194 REMARK 465 GLU A 1195 REMARK 465 TRP A 1196 REMARK 465 VAL A 1197 REMARK 465 LEU A 1198 REMARK 465 LEU A 1199 REMARK 465 SER A 1200 REMARK 465 THR A 1201 REMARK 465 PHE A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 SER A 1205 REMARK 465 GLY A 1206 REMARK 465 LEU A 1207 REMARK 465 ASN A 1208 REMARK 465 ASP A 1209 REMARK 465 ILE A 1210 REMARK 465 PHE A 1211 REMARK 465 GLU A 1212 REMARK 465 ALA A 1213 REMARK 465 GLN A 1214 REMARK 465 LYS A 1215 REMARK 465 ILE A 1216 REMARK 465 GLU A 1217 REMARK 465 TRP A 1218 REMARK 465 HIS A 1219 REMARK 465 GLU A 1220 REMARK 465 GLY A 1221 REMARK 465 HIS A 1222 REMARK 465 HIS A 1223 REMARK 465 HIS A 1224 REMARK 465 HIS A 1225 REMARK 465 HIS A 1226 REMARK 465 HIS A 1227 REMARK 465 SER H 113 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 LYS H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 THR H 219 REMARK 465 HIS H 220 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 MET C -6 REMARK 465 LYS C -5 REMARK 465 ALA C -4 REMARK 465 LYS C -3 REMARK 465 LEU C -2 REMARK 465 LEU C -1 REMARK 465 ILE C 0 REMARK 465 LEU C 1 REMARK 465 LEU C 2 REMARK 465 CYS C 3 REMARK 465 ALA C 4 REMARK 465 LEU C 5 REMARK 465 SER C 6 REMARK 465 ALA C 7 REMARK 465 THR C 8 REMARK 465 ASP C 9 REMARK 465 ALA C 10 REMARK 465 PHE C 333 REMARK 465 GLN C 334 REMARK 465 SER C 335 REMARK 465 ARG C 336 REMARK 465 GLY C 1001 REMARK 465 LEU C 1002 REMARK 465 PHE C 1003 REMARK 465 GLY C 1004 REMARK 465 ASP C 1174 REMARK 465 GLY C 1175 REMARK 465 SER C 1176 REMARK 465 GLY C 1177 REMARK 465 TYR C 1178 REMARK 465 ILE C 1179 REMARK 465 PRO C 1180 REMARK 465 GLU C 1181 REMARK 465 ALA C 1182 REMARK 465 PRO C 1183 REMARK 465 ARG C 1184 REMARK 465 ASP C 1185 REMARK 465 GLY C 1186 REMARK 465 GLN C 1187 REMARK 465 ALA C 1188 REMARK 465 TYR C 1189 REMARK 465 VAL C 1190 REMARK 465 ARG C 1191 REMARK 465 LYS C 1192 REMARK 465 ASP C 1193 REMARK 465 GLY C 1194 REMARK 465 GLU C 1195 REMARK 465 TRP C 1196 REMARK 465 VAL C 1197 REMARK 465 LEU C 1198 REMARK 465 LEU C 1199 REMARK 465 SER C 1200 REMARK 465 THR C 1201 REMARK 465 PHE C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 SER C 1205 REMARK 465 GLY C 1206 REMARK 465 LEU C 1207 REMARK 465 ASN C 1208 REMARK 465 ASP C 1209 REMARK 465 ILE C 1210 REMARK 465 PHE C 1211 REMARK 465 GLU C 1212 REMARK 465 ALA C 1213 REMARK 465 GLN C 1214 REMARK 465 LYS C 1215 REMARK 465 ILE C 1216 REMARK 465 GLU C 1217 REMARK 465 TRP C 1218 REMARK 465 HIS C 1219 REMARK 465 GLU C 1220 REMARK 465 GLY C 1221 REMARK 465 HIS C 1222 REMARK 465 HIS C 1223 REMARK 465 HIS C 1224 REMARK 465 HIS C 1225 REMARK 465 HIS C 1226 REMARK 465 HIS C 1227 REMARK 465 SER G 113 REMARK 465 ALA G 114 REMARK 465 SER G 115 REMARK 465 THR G 116 REMARK 465 LYS G 117 REMARK 465 GLY G 118 REMARK 465 PRO G 119 REMARK 465 SER G 120 REMARK 465 VAL G 121 REMARK 465 PHE G 122 REMARK 465 PRO G 123 REMARK 465 LEU G 124 REMARK 465 ALA G 125 REMARK 465 PRO G 126 REMARK 465 SER G 127 REMARK 465 SER G 128 REMARK 465 LYS G 129 REMARK 465 SER G 130 REMARK 465 THR G 131 REMARK 465 SER G 132 REMARK 465 GLY G 133 REMARK 465 GLY G 134 REMARK 465 THR G 135 REMARK 465 ALA G 136 REMARK 465 ALA G 137 REMARK 465 LEU G 138 REMARK 465 GLY G 139 REMARK 465 CYS G 140 REMARK 465 LEU G 141 REMARK 465 VAL G 142 REMARK 465 LYS G 143 REMARK 465 ASP G 144 REMARK 465 TYR G 145 REMARK 465 PHE G 146 REMARK 465 PRO G 147 REMARK 465 GLU G 148 REMARK 465 PRO G 149 REMARK 465 VAL G 150 REMARK 465 THR G 151 REMARK 465 VAL G 152 REMARK 465 SER G 153 REMARK 465 TRP G 154 REMARK 465 ASN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ALA G 158 REMARK 465 LEU G 159 REMARK 465 THR G 160 REMARK 465 SER G 161 REMARK 465 GLY G 162 REMARK 465 VAL G 163 REMARK 465 HIS G 164 REMARK 465 THR G 165 REMARK 465 PHE G 166 REMARK 465 PRO G 167 REMARK 465 ALA G 168 REMARK 465 VAL G 169 REMARK 465 LEU G 170 REMARK 465 GLN G 171 REMARK 465 SER G 172 REMARK 465 SER G 173 REMARK 465 GLY G 174 REMARK 465 LEU G 175 REMARK 465 TYR G 176 REMARK 465 SER G 177 REMARK 465 LEU G 178 REMARK 465 SER G 179 REMARK 465 SER G 180 REMARK 465 VAL G 181 REMARK 465 VAL G 182 REMARK 465 THR G 183 REMARK 465 VAL G 184 REMARK 465 PRO G 185 REMARK 465 SER G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 LEU G 189 REMARK 465 GLY G 190 REMARK 465 THR G 191 REMARK 465 GLN G 192 REMARK 465 THR G 193 REMARK 465 TYR G 194 REMARK 465 ILE G 195 REMARK 465 CYS G 196 REMARK 465 ASN G 197 REMARK 465 VAL G 198 REMARK 465 ASN G 199 REMARK 465 HIS G 200 REMARK 465 LYS G 201 REMARK 465 PRO G 202 REMARK 465 SER G 203 REMARK 465 ASN G 204 REMARK 465 THR G 205 REMARK 465 LYS G 206 REMARK 465 VAL G 207 REMARK 465 ASP G 208 REMARK 465 LYS G 209 REMARK 465 LYS G 210 REMARK 465 VAL G 211 REMARK 465 GLU G 212 REMARK 465 PRO G 213 REMARK 465 LYS G 214 REMARK 465 SER G 215 REMARK 465 CYS G 216 REMARK 465 ASP G 217 REMARK 465 LYS G 218 REMARK 465 THR G 219 REMARK 465 HIS G 220 REMARK 465 ARG I 108 REMARK 465 THR I 109 REMARK 465 VAL I 110 REMARK 465 ALA I 111 REMARK 465 ALA I 112 REMARK 465 PRO I 113 REMARK 465 SER I 114 REMARK 465 VAL I 115 REMARK 465 PHE I 116 REMARK 465 ILE I 117 REMARK 465 PHE I 118 REMARK 465 PRO I 119 REMARK 465 PRO I 120 REMARK 465 SER I 121 REMARK 465 ASP I 122 REMARK 465 GLU I 123 REMARK 465 GLN I 124 REMARK 465 LEU I 125 REMARK 465 LYS I 126 REMARK 465 SER I 127 REMARK 465 GLY I 128 REMARK 465 THR I 129 REMARK 465 ALA I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 VAL I 133 REMARK 465 CYS I 134 REMARK 465 LEU I 135 REMARK 465 LEU I 136 REMARK 465 ASN I 137 REMARK 465 ASN I 138 REMARK 465 PHE I 139 REMARK 465 TYR I 140 REMARK 465 PRO I 141 REMARK 465 ARG I 142 REMARK 465 GLU I 143 REMARK 465 ALA I 144 REMARK 465 LYS I 145 REMARK 465 VAL I 146 REMARK 465 GLN I 147 REMARK 465 TRP I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 ASP I 151 REMARK 465 ASN I 152 REMARK 465 ALA I 153 REMARK 465 LEU I 154 REMARK 465 GLN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLN I 160 REMARK 465 GLU I 161 REMARK 465 SER I 162 REMARK 465 VAL I 163 REMARK 465 THR I 164 REMARK 465 GLU I 165 REMARK 465 GLN I 166 REMARK 465 ASP I 167 REMARK 465 SER I 168 REMARK 465 LYS I 169 REMARK 465 ASP I 170 REMARK 465 SER I 171 REMARK 465 THR I 172 REMARK 465 TYR I 173 REMARK 465 SER I 174 REMARK 465 LEU I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 THR I 178 REMARK 465 LEU I 179 REMARK 465 THR I 180 REMARK 465 LEU I 181 REMARK 465 SER I 182 REMARK 465 LYS I 183 REMARK 465 ALA I 184 REMARK 465 ASP I 185 REMARK 465 TYR I 186 REMARK 465 GLU I 187 REMARK 465 LYS I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 VAL I 191 REMARK 465 TYR I 192 REMARK 465 ALA I 193 REMARK 465 CYS I 194 REMARK 465 GLU I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLN I 199 REMARK 465 GLY I 200 REMARK 465 LEU I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 PRO I 204 REMARK 465 VAL I 205 REMARK 465 THR I 206 REMARK 465 LYS I 207 REMARK 465 SER I 208 REMARK 465 PHE I 209 REMARK 465 ASN I 210 REMARK 465 ARG I 211 REMARK 465 GLY I 212 REMARK 465 GLU I 213 REMARK 465 CYS I 214 REMARK 465 MET E -6 REMARK 465 LYS E -5 REMARK 465 ALA E -4 REMARK 465 LYS E -3 REMARK 465 LEU E -2 REMARK 465 LEU E -1 REMARK 465 ILE E 0 REMARK 465 LEU E 1 REMARK 465 LEU E 2 REMARK 465 CYS E 3 REMARK 465 ALA E 4 REMARK 465 LEU E 5 REMARK 465 SER E 6 REMARK 465 ALA E 7 REMARK 465 THR E 8 REMARK 465 ASP E 9 REMARK 465 ALA E 10 REMARK 465 PHE E 333 REMARK 465 GLN E 334 REMARK 465 SER E 335 REMARK 465 ARG E 336 REMARK 465 GLY E 1001 REMARK 465 LEU E 1002 REMARK 465 PHE E 1003 REMARK 465 GLY E 1004 REMARK 465 ASP E 1174 REMARK 465 GLY E 1175 REMARK 465 SER E 1176 REMARK 465 GLY E 1177 REMARK 465 TYR E 1178 REMARK 465 ILE E 1179 REMARK 465 PRO E 1180 REMARK 465 GLU E 1181 REMARK 465 ALA E 1182 REMARK 465 PRO E 1183 REMARK 465 ARG E 1184 REMARK 465 ASP E 1185 REMARK 465 GLY E 1186 REMARK 465 GLN E 1187 REMARK 465 ALA E 1188 REMARK 465 TYR E 1189 REMARK 465 VAL E 1190 REMARK 465 ARG E 1191 REMARK 465 LYS E 1192 REMARK 465 ASP E 1193 REMARK 465 GLY E 1194 REMARK 465 GLU E 1195 REMARK 465 TRP E 1196 REMARK 465 VAL E 1197 REMARK 465 LEU E 1198 REMARK 465 LEU E 1199 REMARK 465 SER E 1200 REMARK 465 THR E 1201 REMARK 465 PHE E 1202 REMARK 465 LEU E 1203 REMARK 465 GLY E 1204 REMARK 465 SER E 1205 REMARK 465 GLY E 1206 REMARK 465 LEU E 1207 REMARK 465 ASN E 1208 REMARK 465 ASP E 1209 REMARK 465 ILE E 1210 REMARK 465 PHE E 1211 REMARK 465 GLU E 1212 REMARK 465 ALA E 1213 REMARK 465 GLN E 1214 REMARK 465 LYS E 1215 REMARK 465 ILE E 1216 REMARK 465 GLU E 1217 REMARK 465 TRP E 1218 REMARK 465 HIS E 1219 REMARK 465 GLU E 1220 REMARK 465 GLY E 1221 REMARK 465 HIS E 1222 REMARK 465 HIS E 1223 REMARK 465 HIS E 1224 REMARK 465 HIS E 1225 REMARK 465 HIS E 1226 REMARK 465 HIS E 1227 REMARK 465 SER J 113 REMARK 465 ALA J 114 REMARK 465 SER J 115 REMARK 465 THR J 116 REMARK 465 LYS J 117 REMARK 465 GLY J 118 REMARK 465 PRO J 119 REMARK 465 SER J 120 REMARK 465 VAL J 121 REMARK 465 PHE J 122 REMARK 465 PRO J 123 REMARK 465 LEU J 124 REMARK 465 ALA J 125 REMARK 465 PRO J 126 REMARK 465 SER J 127 REMARK 465 SER J 128 REMARK 465 LYS J 129 REMARK 465 SER J 130 REMARK 465 THR J 131 REMARK 465 SER J 132 REMARK 465 GLY J 133 REMARK 465 GLY J 134 REMARK 465 THR J 135 REMARK 465 ALA J 136 REMARK 465 ALA J 137 REMARK 465 LEU J 138 REMARK 465 GLY J 139 REMARK 465 CYS J 140 REMARK 465 LEU J 141 REMARK 465 VAL J 142 REMARK 465 LYS J 143 REMARK 465 ASP J 144 REMARK 465 TYR J 145 REMARK 465 PHE J 146 REMARK 465 PRO J 147 REMARK 465 GLU J 148 REMARK 465 PRO J 149 REMARK 465 VAL J 150 REMARK 465 THR J 151 REMARK 465 VAL J 152 REMARK 465 SER J 153 REMARK 465 TRP J 154 REMARK 465 ASN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ALA J 158 REMARK 465 LEU J 159 REMARK 465 THR J 160 REMARK 465 SER J 161 REMARK 465 GLY J 162 REMARK 465 VAL J 163 REMARK 465 HIS J 164 REMARK 465 THR J 165 REMARK 465 PHE J 166 REMARK 465 PRO J 167 REMARK 465 ALA J 168 REMARK 465 VAL J 169 REMARK 465 LEU J 170 REMARK 465 GLN J 171 REMARK 465 SER J 172 REMARK 465 SER J 173 REMARK 465 GLY J 174 REMARK 465 LEU J 175 REMARK 465 TYR J 176 REMARK 465 SER J 177 REMARK 465 LEU J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 VAL J 181 REMARK 465 VAL J 182 REMARK 465 THR J 183 REMARK 465 VAL J 184 REMARK 465 PRO J 185 REMARK 465 SER J 186 REMARK 465 SER J 187 REMARK 465 SER J 188 REMARK 465 LEU J 189 REMARK 465 GLY J 190 REMARK 465 THR J 191 REMARK 465 GLN J 192 REMARK 465 THR J 193 REMARK 465 TYR J 194 REMARK 465 ILE J 195 REMARK 465 CYS J 196 REMARK 465 ASN J 197 REMARK 465 VAL J 198 REMARK 465 ASN J 199 REMARK 465 HIS J 200 REMARK 465 LYS J 201 REMARK 465 PRO J 202 REMARK 465 SER J 203 REMARK 465 ASN J 204 REMARK 465 THR J 205 REMARK 465 LYS J 206 REMARK 465 VAL J 207 REMARK 465 ASP J 208 REMARK 465 LYS J 209 REMARK 465 LYS J 210 REMARK 465 VAL J 211 REMARK 465 GLU J 212 REMARK 465 PRO J 213 REMARK 465 LYS J 214 REMARK 465 SER J 215 REMARK 465 CYS J 216 REMARK 465 ASP J 217 REMARK 465 LYS J 218 REMARK 465 THR J 219 REMARK 465 HIS J 220 REMARK 465 ARG K 108 REMARK 465 THR K 109 REMARK 465 VAL K 110 REMARK 465 ALA K 111 REMARK 465 ALA K 112 REMARK 465 PRO K 113 REMARK 465 SER K 114 REMARK 465 VAL K 115 REMARK 465 PHE K 116 REMARK 465 ILE K 117 REMARK 465 PHE K 118 REMARK 465 PRO K 119 REMARK 465 PRO K 120 REMARK 465 SER K 121 REMARK 465 ASP K 122 REMARK 465 GLU K 123 REMARK 465 GLN K 124 REMARK 465 LEU K 125 REMARK 465 LYS K 126 REMARK 465 SER K 127 REMARK 465 GLY K 128 REMARK 465 THR K 129 REMARK 465 ALA K 130 REMARK 465 SER K 131 REMARK 465 VAL K 132 REMARK 465 VAL K 133 REMARK 465 CYS K 134 REMARK 465 LEU K 135 REMARK 465 LEU K 136 REMARK 465 ASN K 137 REMARK 465 ASN K 138 REMARK 465 PHE K 139 REMARK 465 TYR K 140 REMARK 465 PRO K 141 REMARK 465 ARG K 142 REMARK 465 GLU K 143 REMARK 465 ALA K 144 REMARK 465 LYS K 145 REMARK 465 VAL K 146 REMARK 465 GLN K 147 REMARK 465 TRP K 148 REMARK 465 LYS K 149 REMARK 465 VAL K 150 REMARK 465 ASP K 151 REMARK 465 ASN K 152 REMARK 465 ALA K 153 REMARK 465 LEU K 154 REMARK 465 GLN K 155 REMARK 465 SER K 156 REMARK 465 GLY K 157 REMARK 465 ASN K 158 REMARK 465 SER K 159 REMARK 465 GLN K 160 REMARK 465 GLU K 161 REMARK 465 SER K 162 REMARK 465 VAL K 163 REMARK 465 THR K 164 REMARK 465 GLU K 165 REMARK 465 GLN K 166 REMARK 465 ASP K 167 REMARK 465 SER K 168 REMARK 465 LYS K 169 REMARK 465 ASP K 170 REMARK 465 SER K 171 REMARK 465 THR K 172 REMARK 465 TYR K 173 REMARK 465 SER K 174 REMARK 465 LEU K 175 REMARK 465 SER K 176 REMARK 465 SER K 177 REMARK 465 THR K 178 REMARK 465 LEU K 179 REMARK 465 THR K 180 REMARK 465 LEU K 181 REMARK 465 SER K 182 REMARK 465 LYS K 183 REMARK 465 ALA K 184 REMARK 465 ASP K 185 REMARK 465 TYR K 186 REMARK 465 GLU K 187 REMARK 465 LYS K 188 REMARK 465 HIS K 189 REMARK 465 LYS K 190 REMARK 465 VAL K 191 REMARK 465 TYR K 192 REMARK 465 ALA K 193 REMARK 465 CYS K 194 REMARK 465 GLU K 195 REMARK 465 VAL K 196 REMARK 465 THR K 197 REMARK 465 HIS K 198 REMARK 465 GLN K 199 REMARK 465 GLY K 200 REMARK 465 LEU K 201 REMARK 465 SER K 202 REMARK 465 SER K 203 REMARK 465 PRO K 204 REMARK 465 VAL K 205 REMARK 465 THR K 206 REMARK 465 LYS K 207 REMARK 465 SER K 208 REMARK 465 PHE K 209 REMARK 465 ASN K 210 REMARK 465 ARG K 211 REMARK 465 GLY K 212 REMARK 465 GLU K 213 REMARK 465 CYS K 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 ARG L 46 CB - CG - CD ANGL. DEV. = -16.6 DEGREES REMARK 500 LYS I 50 CB - CA - C ANGL. DEV. = 12.6 DEGREES REMARK 500 LYS K 50 CB - CA - C ANGL. DEV. = 12.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASP A 45 26.13 -140.41 REMARK 500 LYS A 55 -137.02 55.16 REMARK 500 SER A 117 55.18 -97.75 REMARK 500 ASP A 285 41.67 -142.50 REMARK 500 ILE A 304 -62.19 -94.52 REMARK 500 ARG A 317 53.98 -95.68 REMARK 500 PHE A1063 124.64 -35.16 REMARK 500 ARG A1127 -119.67 52.69 REMARK 500 ILE H 48 -60.15 -99.74 REMARK 500 LYS L 50 -176.17 76.60 REMARK 500 ARG L 68 -102.68 49.63 REMARK 500 THR C 28 -167.83 -126.34 REMARK 500 SER C 117 56.56 -98.17 REMARK 500 ASP C 285 43.92 -140.25 REMARK 500 ASN C 303 35.38 -141.13 REMARK 500 ILE C 304 -62.09 -98.18 REMARK 500 ARG C 317 48.77 -94.36 REMARK 500 ARG C1127 -124.31 53.12 REMARK 500 ILE G 48 -62.78 -97.62 REMARK 500 LYS I 50 -173.44 70.73 REMARK 500 ARG I 68 -102.02 51.24 REMARK 500 THR E 28 -169.05 -123.58 REMARK 500 LEU E 81 77.58 -102.66 REMARK 500 SER E 117 56.84 -99.08 REMARK 500 ASP E 285 42.80 -141.40 REMARK 500 ASN E 303 34.33 -140.65 REMARK 500 ILE E 304 -62.04 -94.40 REMARK 500 ARG E 317 47.00 -94.04 REMARK 500 ARG E1127 -124.53 53.19 REMARK 500 ASN E1135 29.36 43.34 REMARK 500 ILE J 48 -62.29 -100.39 REMARK 500 LYS K 50 -172.39 70.27 REMARK 500 ARG K 68 -103.16 50.87 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 8VEB RELATED DB: PDB REMARK 900 1E08 WITH GROUP 1 INFLUENZA TRIMER REMARK 900 RELATED ID: 8VEF RELATED DB: PDB REMARK 900 1E08 UCA WITH GROUP 1 INFLUENZA TRIMER REMARK 900 RELATED ID: 8T1G RELATED DB: PDB REMARK 900 1E11 WITH GROUP 2 INFLUENZA TRIMER REMARK 900 RELATED ID: 8VEE RELATED DB: PDB REMARK 900 1E08 WITH GROUP 2 INFLUENZA TRIMER REMARK 900 RELATED ID: EMD-43170 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF ANTIBODY T5-1E11 IN COMPLEX WITH STABILIZED REMARK 900 H1N1 INFLUENZA HEMAGGLUTININ TRIMER (A/KIEV/1/57) DBREF 8VED A -6 1227 PDB 8VED 8VED -6 1227 DBREF 8VED H 1 220 PDB 8VED 8VED 1 220 DBREF 8VED L 1 214 PDB 8VED 8VED 1 214 DBREF 8VED C -6 1227 PDB 8VED 8VED -6 1227 DBREF 8VED G 1 220 PDB 8VED 8VED 1 220 DBREF 8VED I 1 214 PDB 8VED 8VED 1 214 DBREF 8VED E -6 1227 PDB 8VED 8VED -6 1227 DBREF 8VED J 1 220 PDB 8VED 8VED 1 220 DBREF 8VED K 1 214 PDB 8VED 8VED 1 214 SEQRES 1 A 570 MET LYS ALA LYS LEU LEU ILE LEU LEU CYS ALA LEU SER SEQRES 2 A 570 ALA THR ASP ALA ASP THR ILE CYS ILE GLY TYR HIS ALA SEQRES 3 A 570 ASN ASN SER THR ASP THR VAL ASP THR VAL CYS GLU LYS SEQRES 4 A 570 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 A 570 SER HIS ASN GLY LYS LEU CYS ARG LEU LYS GLY LYS ALA SEQRES 6 A 570 PRO LEU GLN LEU GLY ASN CYS ASN ILE ALA GLY TRP VAL SEQRES 7 A 570 LEU GLY ASN PRO GLU CYS GLU SER LEU LEU SER ASN ARG SEQRES 8 A 570 SER TRP SER TYR ILE ALA GLU THR PRO ASN SER GLU ASN SEQRES 9 A 570 GLY THR CYS PHE PRO GLY ASP PHE ALA ASP TYR GLU GLU SEQRES 10 A 570 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 A 570 PHE GLU ILE PHE PRO LYS GLU ARG SER TRP PRO ASN HIS SEQRES 12 A 570 THR THR ARG GLY VAL THR ALA ALA CYS PRO HIS ALA MET SEQRES 13 A 570 LYS SER SER PHE TYR LYS ASN LEU VAL TRP LEU THR GLU SEQRES 14 A 570 ALA ASN GLY SER TYR PRO ASN LEU SER ARG SER TYR VAL SEQRES 15 A 570 ASN ASN GLN GLU LYS GLU VAL LEU VAL LEU TRP GLY VAL SEQRES 16 A 570 HIS HIS PRO SER ASN ILE GLU ASP GLN ARG THR LEU TYR SEQRES 17 A 570 ARG LYS ASP ASN ALA TYR VAL SER VAL VAL SER SER ASN SEQRES 18 A 570 TYR ASN ARG ARG PHE THR PRO GLU ILE ALA LYS ARG PRO SEQRES 19 A 570 LYS VAL ARG GLY GLN SER GLY ARG ILE ASN TYR TYR TRP SEQRES 20 A 570 THR LEU LEU GLU PRO GLY ASP THR ILE ILE PHE GLU ALA SEQRES 21 A 570 THR GLY ASN LEU ILE ALA PRO TRP TYR ALA PHE ALA LEU SEQRES 22 A 570 SER ARG GLY PRO GLY SER GLY ILE ILE THR SER ASN ALA SEQRES 23 A 570 PRO LEU ASP GLU CYS ASP THR LYS CYS GLN THR PRO GLN SEQRES 24 A 570 GLY ALA ILE ASN SER SER LEU PRO PHE GLN ASN ILE HIS SEQRES 25 A 570 PRO VAL THR ILE GLY GLU CYS PRO LYS TYR VAL ARG SER SEQRES 26 A 570 THR LYS LEU ARG MET VAL THR GLY LEU ARG ASN ILE PRO SEQRES 27 A 570 SER PHE GLN SER ARG GLY LEU PHE GLY ALA ILE ALA GLY SEQRES 28 A 570 PHE ILE GLU GLY GLY TRP THR GLY MET MET ASP GLY TRP SEQRES 29 A 570 TYR GLY TYR HIS HIS GLN ASN GLU GLN GLY SER GLY TYR SEQRES 30 A 570 ALA ALA ASP GLN LYS SER THR GLN ASN ALA ILE ASN CYS SEQRES 31 A 570 ILE THR ASN LYS VAL ASN SER VAL ILE GLU LYS MET ASN SEQRES 32 A 570 THR GLN PHE THR ALA VAL GLY LYS GLU PHE ASN LYS LEU SEQRES 33 A 570 GLU LYS ARG MET GLU ASN LEU ASN LYS LYS VAL ASP ASP SEQRES 34 A 570 GLY PHE LEU ASP ILE TRP THR TYR ASN ALA GLU LEU LEU SEQRES 35 A 570 VAL LEU LEU GLU ASN GLU ARG THR LEU ASP PHE HIS ASP SEQRES 36 A 570 SER ASN VAL LYS ASN LEU TYR GLU LYS VAL LYS ASN GLN SEQRES 37 A 570 LEU ARG ASN ASN ALA LYS GLU LEU GLY ASN GLY CYS PHE SEQRES 38 A 570 GLU PHE TYR HIS LYS CYS ASP ASN GLU CYS MET GLU SER SEQRES 39 A 570 VAL LYS ASN GLY THR TYR ASP TYR PRO LYS TYR SER GLU SEQRES 40 A 570 GLU SER LYS LEU ASN ARG GLU LYS ILE ASP GLY SER GLY SEQRES 41 A 570 TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL SEQRES 42 A 570 ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU SEQRES 43 A 570 GLY SER GLY LEU ASN ASP ILE PHE GLU ALA GLN LYS ILE SEQRES 44 A 570 GLU TRP HIS GLU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 H 234 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 H 234 PRO SER GLU THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 H 234 ALA SER VAL SER SER TYR PHE TRP SER TRP ILE ARG GLN SEQRES 4 H 234 PRO ALA GLY LYS ALA LEU GLU TRP ILE GLY ARG ILE TYR SEQRES 5 H 234 THR SER GLY ASN THR LYS SER ASN PRO SER LEU GLU SER SEQRES 6 H 234 ARG VAL THR MET SER LEU ASP ALA SER LYS ASP GLN PHE SEQRES 7 H 234 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 H 234 VAL TYR TYR CYS ALA ALA GLY ARG LEU ASP TYR SER ASP SEQRES 9 H 234 THR THR GLY TYR TYR LYS PRO PRO PRO LEU ASP TYR TRP SEQRES 10 H 234 GLY GLN GLY ALA LEU VAL THR VAL SER SER ALA SER THR SEQRES 11 H 234 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 H 234 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 H 234 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 H 234 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 H 234 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 H 234 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 H 234 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 H 234 ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS THR HIS SEQRES 1 L 219 ASP VAL VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 L 219 THR LEU GLY GLN PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 L 219 GLN GLY LEU ALA PHE LEU ASP GLY ASN THR TYR LEU SER SEQRES 4 L 219 TRP PHE GLN GLN ARG PRO GLY GLN SER PRO ARG ARG LEU SEQRES 5 L 219 ILE TYR LYS VAL SER ASN ARG ASP SER GLY VAL PRO ASP SEQRES 6 L 219 ARG PHE SER GLY SER GLY SER ARG THR ASP PHE THR LEU SEQRES 7 L 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 L 219 TYR CYS MET GLN GLY THR HIS TRP PRO LEU THR PHE GLY SEQRES 9 L 219 GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 L 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 L 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 L 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 L 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 L 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 L 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 L 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 L 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 C 570 MET LYS ALA LYS LEU LEU ILE LEU LEU CYS ALA LEU SER SEQRES 2 C 570 ALA THR ASP ALA ASP THR ILE CYS ILE GLY TYR HIS ALA SEQRES 3 C 570 ASN ASN SER THR ASP THR VAL ASP THR VAL CYS GLU LYS SEQRES 4 C 570 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 C 570 SER HIS ASN GLY LYS LEU CYS ARG LEU LYS GLY LYS ALA SEQRES 6 C 570 PRO LEU GLN LEU GLY ASN CYS ASN ILE ALA GLY TRP VAL SEQRES 7 C 570 LEU GLY ASN PRO GLU CYS GLU SER LEU LEU SER ASN ARG SEQRES 8 C 570 SER TRP SER TYR ILE ALA GLU THR PRO ASN SER GLU ASN SEQRES 9 C 570 GLY THR CYS PHE PRO GLY ASP PHE ALA ASP TYR GLU GLU SEQRES 10 C 570 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 C 570 PHE GLU ILE PHE PRO LYS GLU ARG SER TRP PRO ASN HIS SEQRES 12 C 570 THR THR ARG GLY VAL THR ALA ALA CYS PRO HIS ALA MET SEQRES 13 C 570 LYS SER SER PHE TYR LYS ASN LEU VAL TRP LEU THR GLU SEQRES 14 C 570 ALA ASN GLY SER TYR PRO ASN LEU SER ARG SER TYR VAL SEQRES 15 C 570 ASN ASN GLN GLU LYS GLU VAL LEU VAL LEU TRP GLY VAL SEQRES 16 C 570 HIS HIS PRO SER ASN ILE GLU ASP GLN ARG THR LEU TYR SEQRES 17 C 570 ARG LYS ASP ASN ALA TYR VAL SER VAL VAL SER SER ASN SEQRES 18 C 570 TYR ASN ARG ARG PHE THR PRO GLU ILE ALA LYS ARG PRO SEQRES 19 C 570 LYS VAL ARG GLY GLN SER GLY ARG ILE ASN TYR TYR TRP SEQRES 20 C 570 THR LEU LEU GLU PRO GLY ASP THR ILE ILE PHE GLU ALA SEQRES 21 C 570 THR GLY ASN LEU ILE ALA PRO TRP TYR ALA PHE ALA LEU SEQRES 22 C 570 SER ARG GLY PRO GLY SER GLY ILE ILE THR SER ASN ALA SEQRES 23 C 570 PRO LEU ASP GLU CYS ASP THR LYS CYS GLN THR PRO GLN SEQRES 24 C 570 GLY ALA ILE ASN SER SER LEU PRO PHE GLN ASN ILE HIS SEQRES 25 C 570 PRO VAL THR ILE GLY GLU CYS PRO LYS TYR VAL ARG SER SEQRES 26 C 570 THR LYS LEU ARG MET VAL THR GLY LEU ARG ASN ILE PRO SEQRES 27 C 570 SER PHE GLN SER ARG GLY LEU PHE GLY ALA ILE ALA GLY SEQRES 28 C 570 PHE ILE GLU GLY GLY TRP THR GLY MET MET ASP GLY TRP SEQRES 29 C 570 TYR GLY TYR HIS HIS GLN ASN GLU GLN GLY SER GLY TYR SEQRES 30 C 570 ALA ALA ASP GLN LYS SER THR GLN ASN ALA ILE ASN CYS SEQRES 31 C 570 ILE THR ASN LYS VAL ASN SER VAL ILE GLU LYS MET ASN SEQRES 32 C 570 THR GLN PHE THR ALA VAL GLY LYS GLU PHE ASN LYS LEU SEQRES 33 C 570 GLU LYS ARG MET GLU ASN LEU ASN LYS LYS VAL ASP ASP SEQRES 34 C 570 GLY PHE LEU ASP ILE TRP THR TYR ASN ALA GLU LEU LEU SEQRES 35 C 570 VAL LEU LEU GLU ASN GLU ARG THR LEU ASP PHE HIS ASP SEQRES 36 C 570 SER ASN VAL LYS ASN LEU TYR GLU LYS VAL LYS ASN GLN SEQRES 37 C 570 LEU ARG ASN ASN ALA LYS GLU LEU GLY ASN GLY CYS PHE SEQRES 38 C 570 GLU PHE TYR HIS LYS CYS ASP ASN GLU CYS MET GLU SER SEQRES 39 C 570 VAL LYS ASN GLY THR TYR ASP TYR PRO LYS TYR SER GLU SEQRES 40 C 570 GLU SER LYS LEU ASN ARG GLU LYS ILE ASP GLY SER GLY SEQRES 41 C 570 TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL SEQRES 42 C 570 ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU SEQRES 43 C 570 GLY SER GLY LEU ASN ASP ILE PHE GLU ALA GLN LYS ILE SEQRES 44 C 570 GLU TRP HIS GLU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 G 234 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 G 234 PRO SER GLU THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 G 234 ALA SER VAL SER SER TYR PHE TRP SER TRP ILE ARG GLN SEQRES 4 G 234 PRO ALA GLY LYS ALA LEU GLU TRP ILE GLY ARG ILE TYR SEQRES 5 G 234 THR SER GLY ASN THR LYS SER ASN PRO SER LEU GLU SER SEQRES 6 G 234 ARG VAL THR MET SER LEU ASP ALA SER LYS ASP GLN PHE SEQRES 7 G 234 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 G 234 VAL TYR TYR CYS ALA ALA GLY ARG LEU ASP TYR SER ASP SEQRES 9 G 234 THR THR GLY TYR TYR LYS PRO PRO PRO LEU ASP TYR TRP SEQRES 10 G 234 GLY GLN GLY ALA LEU VAL THR VAL SER SER ALA SER THR SEQRES 11 G 234 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 G 234 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 G 234 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 G 234 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 G 234 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 G 234 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 G 234 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 G 234 ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS THR HIS SEQRES 1 I 219 ASP VAL VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 I 219 THR LEU GLY GLN PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 I 219 GLN GLY LEU ALA PHE LEU ASP GLY ASN THR TYR LEU SER SEQRES 4 I 219 TRP PHE GLN GLN ARG PRO GLY GLN SER PRO ARG ARG LEU SEQRES 5 I 219 ILE TYR LYS VAL SER ASN ARG ASP SER GLY VAL PRO ASP SEQRES 6 I 219 ARG PHE SER GLY SER GLY SER ARG THR ASP PHE THR LEU SEQRES 7 I 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 I 219 TYR CYS MET GLN GLY THR HIS TRP PRO LEU THR PHE GLY SEQRES 9 I 219 GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 I 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 I 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 I 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 I 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 I 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 I 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 I 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 I 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 E 570 MET LYS ALA LYS LEU LEU ILE LEU LEU CYS ALA LEU SER SEQRES 2 E 570 ALA THR ASP ALA ASP THR ILE CYS ILE GLY TYR HIS ALA SEQRES 3 E 570 ASN ASN SER THR ASP THR VAL ASP THR VAL CYS GLU LYS SEQRES 4 E 570 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 E 570 SER HIS ASN GLY LYS LEU CYS ARG LEU LYS GLY LYS ALA SEQRES 6 E 570 PRO LEU GLN LEU GLY ASN CYS ASN ILE ALA GLY TRP VAL SEQRES 7 E 570 LEU GLY ASN PRO GLU CYS GLU SER LEU LEU SER ASN ARG SEQRES 8 E 570 SER TRP SER TYR ILE ALA GLU THR PRO ASN SER GLU ASN SEQRES 9 E 570 GLY THR CYS PHE PRO GLY ASP PHE ALA ASP TYR GLU GLU SEQRES 10 E 570 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 E 570 PHE GLU ILE PHE PRO LYS GLU ARG SER TRP PRO ASN HIS SEQRES 12 E 570 THR THR ARG GLY VAL THR ALA ALA CYS PRO HIS ALA MET SEQRES 13 E 570 LYS SER SER PHE TYR LYS ASN LEU VAL TRP LEU THR GLU SEQRES 14 E 570 ALA ASN GLY SER TYR PRO ASN LEU SER ARG SER TYR VAL SEQRES 15 E 570 ASN ASN GLN GLU LYS GLU VAL LEU VAL LEU TRP GLY VAL SEQRES 16 E 570 HIS HIS PRO SER ASN ILE GLU ASP GLN ARG THR LEU TYR SEQRES 17 E 570 ARG LYS ASP ASN ALA TYR VAL SER VAL VAL SER SER ASN SEQRES 18 E 570 TYR ASN ARG ARG PHE THR PRO GLU ILE ALA LYS ARG PRO SEQRES 19 E 570 LYS VAL ARG GLY GLN SER GLY ARG ILE ASN TYR TYR TRP SEQRES 20 E 570 THR LEU LEU GLU PRO GLY ASP THR ILE ILE PHE GLU ALA SEQRES 21 E 570 THR GLY ASN LEU ILE ALA PRO TRP TYR ALA PHE ALA LEU SEQRES 22 E 570 SER ARG GLY PRO GLY SER GLY ILE ILE THR SER ASN ALA SEQRES 23 E 570 PRO LEU ASP GLU CYS ASP THR LYS CYS GLN THR PRO GLN SEQRES 24 E 570 GLY ALA ILE ASN SER SER LEU PRO PHE GLN ASN ILE HIS SEQRES 25 E 570 PRO VAL THR ILE GLY GLU CYS PRO LYS TYR VAL ARG SER SEQRES 26 E 570 THR LYS LEU ARG MET VAL THR GLY LEU ARG ASN ILE PRO SEQRES 27 E 570 SER PHE GLN SER ARG GLY LEU PHE GLY ALA ILE ALA GLY SEQRES 28 E 570 PHE ILE GLU GLY GLY TRP THR GLY MET MET ASP GLY TRP SEQRES 29 E 570 TYR GLY TYR HIS HIS GLN ASN GLU GLN GLY SER GLY TYR SEQRES 30 E 570 ALA ALA ASP GLN LYS SER THR GLN ASN ALA ILE ASN CYS SEQRES 31 E 570 ILE THR ASN LYS VAL ASN SER VAL ILE GLU LYS MET ASN SEQRES 32 E 570 THR GLN PHE THR ALA VAL GLY LYS GLU PHE ASN LYS LEU SEQRES 33 E 570 GLU LYS ARG MET GLU ASN LEU ASN LYS LYS VAL ASP ASP SEQRES 34 E 570 GLY PHE LEU ASP ILE TRP THR TYR ASN ALA GLU LEU LEU SEQRES 35 E 570 VAL LEU LEU GLU ASN GLU ARG THR LEU ASP PHE HIS ASP SEQRES 36 E 570 SER ASN VAL LYS ASN LEU TYR GLU LYS VAL LYS ASN GLN SEQRES 37 E 570 LEU ARG ASN ASN ALA LYS GLU LEU GLY ASN GLY CYS PHE SEQRES 38 E 570 GLU PHE TYR HIS LYS CYS ASP ASN GLU CYS MET GLU SER SEQRES 39 E 570 VAL LYS ASN GLY THR TYR ASP TYR PRO LYS TYR SER GLU SEQRES 40 E 570 GLU SER LYS LEU ASN ARG GLU LYS ILE ASP GLY SER GLY SEQRES 41 E 570 TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL SEQRES 42 E 570 ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU SEQRES 43 E 570 GLY SER GLY LEU ASN ASP ILE PHE GLU ALA GLN LYS ILE SEQRES 44 E 570 GLU TRP HIS GLU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 J 234 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 J 234 PRO SER GLU THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 J 234 ALA SER VAL SER SER TYR PHE TRP SER TRP ILE ARG GLN SEQRES 4 J 234 PRO ALA GLY LYS ALA LEU GLU TRP ILE GLY ARG ILE TYR SEQRES 5 J 234 THR SER GLY ASN THR LYS SER ASN PRO SER LEU GLU SER SEQRES 6 J 234 ARG VAL THR MET SER LEU ASP ALA SER LYS ASP GLN PHE SEQRES 7 J 234 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 J 234 VAL TYR TYR CYS ALA ALA GLY ARG LEU ASP TYR SER ASP SEQRES 9 J 234 THR THR GLY TYR TYR LYS PRO PRO PRO LEU ASP TYR TRP SEQRES 10 J 234 GLY GLN GLY ALA LEU VAL THR VAL SER SER ALA SER THR SEQRES 11 J 234 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 J 234 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 J 234 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 J 234 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 J 234 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 J 234 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 J 234 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 J 234 ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS THR HIS SEQRES 1 K 219 ASP VAL VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 K 219 THR LEU GLY GLN PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 K 219 GLN GLY LEU ALA PHE LEU ASP GLY ASN THR TYR LEU SER SEQRES 4 K 219 TRP PHE GLN GLN ARG PRO GLY GLN SER PRO ARG ARG LEU SEQRES 5 K 219 ILE TYR LYS VAL SER ASN ARG ASP SER GLY VAL PRO ASP SEQRES 6 K 219 ARG PHE SER GLY SER GLY SER ARG THR ASP PHE THR LEU SEQRES 7 K 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 K 219 TYR CYS MET GLN GLY THR HIS TRP PRO LEU THR PHE GLY SEQRES 9 K 219 GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 K 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 K 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 K 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 K 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 K 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 K 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 K 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 K 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET MAN O 4 11 HET MAN O 5 11 HET MAN O 6 11 HET MAN O 7 11 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET BMA Q 3 11 HET MAN Q 4 11 HET MAN Q 5 11 HET MAN Q 6 11 HET MAN Q 7 11 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET MAN U 6 11 HET MAN U 7 11 HET NAG A2001 14 HET NAG A2002 14 HET NAG A2003 14 HET NAG A2004 14 HET NAG A2005 14 HET NAG C2001 14 HET NAG C2002 14 HET NAG C2003 14 HET NAG C2004 14 HET NAG C2005 14 HET NAG C2006 14 HET NAG E2001 14 HET NAG E2002 14 HET NAG E2003 14 HET NAG E2004 14 HET NAG E2005 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 34(C8 H15 N O6) FORMUL 12 BMA 3(C6 H12 O6) FORMUL 12 MAN 12(C6 H12 O6) HELIX 1 AA1 ASN A 66 GLY A 73 1 8 HELIX 2 AA2 ASP A 107 SER A 117 1 11 HELIX 3 AA3 ASN A 193 ARG A 202 1 10 HELIX 4 AA4 ASP A 1037 MET A 1059 1 23 HELIX 5 AA5 GLU A 1074 ARG A 1127 1 54 HELIX 6 AA6 ASP A 1145 ASN A 1154 1 10 HELIX 7 AA7 TYR A 1159 LYS A 1161 5 3 HELIX 8 AA8 TYR A 1162 ILE A 1173 1 12 HELIX 9 AA9 THR H 83 THR H 87 5 5 HELIX 10 AB1 THR H 100B LYS H 100G 5 6 HELIX 11 AB2 GLU L 79 VAL L 83 5 5 HELIX 12 AB3 ASN C 66 GLY C 73 1 8 HELIX 13 AB4 ASP C 107 SER C 117 1 11 HELIX 14 AB5 ASN C 193 ARG C 202 1 10 HELIX 15 AB6 LYS C 1039 MET C 1059 1 21 HELIX 16 AB7 GLU C 1074 ARG C 1127 1 54 HELIX 17 AB8 ASP C 1145 ASN C 1154 1 10 HELIX 18 AB9 TYR C 1162 ILE C 1173 1 12 HELIX 19 AC1 THR G 83 THR G 87 5 5 HELIX 20 AC2 THR G 100B LYS G 100G 5 6 HELIX 21 AC3 GLU I 79 VAL I 83 5 5 HELIX 22 AC4 ASN E 66 GLY E 73 1 8 HELIX 23 AC5 ASP E 107 SER E 117 1 11 HELIX 24 AC6 PRO E 128 TRP E 133 1 6 HELIX 25 AC7 ASN E 193 ARG E 202 1 10 HELIX 26 AC8 ASP E 1037 MET E 1059 1 23 HELIX 27 AC9 GLU E 1074 ARG E 1127 1 54 HELIX 28 AD1 ASP E 1145 ASN E 1154 1 10 HELIX 29 AD2 TYR E 1159 LYS E 1161 5 3 HELIX 30 AD3 TYR E 1162 ILE E 1173 1 12 HELIX 31 AD4 THR J 83 THR J 87 5 5 HELIX 32 AD5 THR J 100B LYS J 100G 5 6 HELIX 33 AD6 GLU K 79 VAL K 83 5 5 SHEET 1 AA1 5 SER A1032 ALA A1036 0 SHEET 2 AA1 5 TYR A1022 GLN A1027 -1 N HIS A1026 O GLY A1033 SHEET 3 AA1 5 THR A 12 TYR A 17 -1 N THR A 12 O GLN A1027 SHEET 4 AA1 5 CYS A1137 PHE A1140 -1 O PHE A1138 N ILE A 13 SHEET 5 AA1 5 ALA A1130 GLU A1132 -1 N LYS A1131 O GLU A1139 SHEET 1 AA2 2 ASP A 24 VAL A 26 0 SHEET 2 AA2 2 VAL A 34 VAL A 36 -1 O VAL A 34 N VAL A 26 SHEET 1 AA3 2 SER A 39 ASN A 41 0 SHEET 2 AA3 2 ARG A 322 VAL A 324 -1 O MET A 323 N VAL A 40 SHEET 1 AA4 3 LEU A 43 GLU A 44 0 SHEET 2 AA4 3 PHE A 301 GLN A 302 1 O PHE A 301 N GLU A 44 SHEET 3 AA4 3 LYS A 314 TYR A 315 1 O LYS A 314 N GLN A 302 SHEET 1 AA5 3 LEU A 60 GLN A 61 0 SHEET 2 AA5 3 ILE A 89 GLU A 91 1 O ALA A 90 N LEU A 60 SHEET 3 AA5 3 ILE A 274 THR A 276 1 O ILE A 275 N GLU A 91 SHEET 1 AA6 5 ARG A 84 SER A 85 0 SHEET 2 AA6 5 VAL A 118 GLU A 125 -1 O PHE A 121 N ARG A 84 SHEET 3 AA6 5 TYR A 262 ARG A 268 -1 O SER A 267 N SER A 119 SHEET 4 AA6 5 GLU A 181 HIS A 190 -1 N GLU A 181 O LEU A 266 SHEET 5 AA6 5 ARG A 235 LEU A 243 -1 O ARG A 235 N HIS A 190 SHEET 1 AA7 2 LEU A 157 TRP A 159 0 SHEET 2 AA7 2 ILE A 258 PRO A 260 -1 O ALA A 259 N VAL A 158 SHEET 1 AA8 4 LEU A 170 VAL A 175 0 SHEET 2 AA8 4 THR A 248 ALA A 253 -1 O PHE A 251 N ARG A 172 SHEET 3 AA8 4 VAL A 208 SER A 212 -1 N SER A 209 O GLU A 252 SHEET 4 AA8 4 ASN A 216 PHE A 219 -1 O PHE A 219 N VAL A 208 SHEET 1 AA9 3 GLY A 293 ALA A 294 0 SHEET 2 AA9 3 CYS A 288 THR A 290 -1 N THR A 290 O GLY A 293 SHEET 3 AA9 3 ILE A 309 GLY A 310 -1 O ILE A 309 N GLN A 289 SHEET 1 AB1 4 GLN H 3 SER H 7 0 SHEET 2 AB1 4 LEU H 18 SER H 25 -1 O THR H 23 N GLN H 5 SHEET 3 AB1 4 GLN H 77 LEU H 82 -1 O LEU H 82 N LEU H 18 SHEET 4 AB1 4 VAL H 67 ASP H 72 -1 N SER H 70 O SER H 79 SHEET 1 AB2 6 LEU H 11 VAL H 12 0 SHEET 2 AB2 6 ALA H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB2 6 ALA H 88 ARG H 96 -1 N ALA H 88 O VAL H 109 SHEET 4 AB2 6 TYR H 32 GLN H 39 -1 N ILE H 37 O TYR H 91 SHEET 5 AB2 6 GLU H 46 ILE H 51 -1 O ILE H 48 N TRP H 36 SHEET 6 AB2 6 THR H 57 SER H 59 -1 O LYS H 58 N ARG H 50 SHEET 1 AB3 4 MET L 4 SER L 7 0 SHEET 2 AB3 4 ALA L 19 SER L 25 -1 O SER L 22 N SER L 7 SHEET 3 AB3 4 ASP L 70 ILE L 75 -1 O PHE L 71 N CYS L 23 SHEET 4 AB3 4 PHE L 62 SER L 67 -1 N SER L 63 O LYS L 74 SHEET 1 AB4 2 VAL L 13 THR L 14 0 SHEET 2 AB4 2 ILE L 106 LYS L 107 1 O LYS L 107 N VAL L 13 SHEET 1 AB5 4 ARG L 45 ILE L 48 0 SHEET 2 AB5 4 LEU L 33 GLN L 38 -1 N GLN L 37 O ARG L 45 SHEET 3 AB5 4 GLY L 84 GLN L 90 -1 O VAL L 85 N GLN L 38 SHEET 4 AB5 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AB6 4 ARG L 45 ILE L 48 0 SHEET 2 AB6 4 LEU L 33 GLN L 38 -1 N GLN L 37 O ARG L 45 SHEET 3 AB6 4 GLY L 84 GLN L 90 -1 O VAL L 85 N GLN L 38 SHEET 4 AB6 4 THR L 102 VAL L 104 -1 O VAL L 104 N GLY L 84 SHEET 1 AB7 5 SER C1032 TYR C1034 0 SHEET 2 AB7 5 TYR C1022 GLN C1027 -1 N HIS C1026 O GLY C1033 SHEET 3 AB7 5 THR C 12 TYR C 17 -1 N THR C 12 O GLN C1027 SHEET 4 AB7 5 CYS C1137 PHE C1140 -1 O PHE C1138 N ILE C 13 SHEET 5 AB7 5 ALA C1130 GLU C1132 -1 N LYS C1131 O GLU C1139 SHEET 1 AB8 2 ASP C 24 VAL C 26 0 SHEET 2 AB8 2 VAL C 34 VAL C 36 -1 O VAL C 34 N VAL C 26 SHEET 1 AB9 2 SER C 39 ASN C 41 0 SHEET 2 AB9 2 ARG C 322 VAL C 324 -1 O MET C 323 N VAL C 40 SHEET 1 AC1 3 LEU C 43 GLU C 44 0 SHEET 2 AC1 3 PHE C 301 GLN C 302 1 O PHE C 301 N GLU C 44 SHEET 3 AC1 3 LYS C 314 TYR C 315 1 O LYS C 314 N GLN C 302 SHEET 1 AC2 3 LEU C 60 GLN C 61 0 SHEET 2 AC2 3 ILE C 89 GLU C 91 1 O ALA C 90 N LEU C 60 SHEET 3 AC2 3 ILE C 274 THR C 276 1 O ILE C 275 N GLU C 91 SHEET 1 AC3 5 VAL C 118 GLU C 125 0 SHEET 2 AC3 5 TYR C 262 ARG C 268 -1 O ALA C 263 N PHE C 124 SHEET 3 AC3 5 GLU C 181 HIS C 190 -1 N LEU C 183 O PHE C 264 SHEET 4 AC3 5 LEU C 257 PRO C 260 -1 O ILE C 258 N GLY C 187 SHEET 5 AC3 5 LEU C 157 TRP C 159 -1 N VAL C 158 O ALA C 259 SHEET 1 AC4 4 VAL C 118 GLU C 125 0 SHEET 2 AC4 4 TYR C 262 ARG C 268 -1 O ALA C 263 N PHE C 124 SHEET 3 AC4 4 GLU C 181 HIS C 190 -1 N LEU C 183 O PHE C 264 SHEET 4 AC4 4 ARG C 235 LEU C 243 -1 O ARG C 235 N HIS C 190 SHEET 1 AC5 4 LEU C 170 VAL C 175 0 SHEET 2 AC5 4 THR C 248 ALA C 253 -1 O PHE C 251 N ARG C 172 SHEET 3 AC5 4 VAL C 208 VAL C 211 -1 N SER C 209 O GLU C 252 SHEET 4 AC5 4 ASN C 216 PHE C 219 -1 O PHE C 219 N VAL C 208 SHEET 1 AC6 2 CYS C 288 GLN C 289 0 SHEET 2 AC6 2 ILE C 309 GLY C 310 -1 O ILE C 309 N GLN C 289 SHEET 1 AC7 4 GLN G 3 SER G 7 0 SHEET 2 AC7 4 LEU G 18 SER G 25 -1 O THR G 23 N GLN G 5 SHEET 3 AC7 4 GLN G 77 LEU G 82 -1 O LEU G 82 N LEU G 18 SHEET 4 AC7 4 VAL G 67 ASP G 72 -1 N SER G 70 O SER G 79 SHEET 1 AC8 5 LEU G 11 VAL G 12 0 SHEET 2 AC8 5 ALA G 107 VAL G 111 1 O THR G 110 N VAL G 12 SHEET 3 AC8 5 ALA G 88 ARG G 96 -1 N TYR G 90 O ALA G 107 SHEET 4 AC8 5 TYR G 32 GLN G 39 -1 N ILE G 37 O TYR G 91 SHEET 5 AC8 5 GLU G 46 ILE G 51 -1 O GLU G 46 N ARG G 38 SHEET 1 AC9 4 MET I 4 SER I 7 0 SHEET 2 AC9 4 ALA I 19 SER I 25 -1 O SER I 22 N SER I 7 SHEET 3 AC9 4 ASP I 70 ILE I 75 -1 O PHE I 71 N CYS I 23 SHEET 4 AC9 4 PHE I 62 SER I 67 -1 N SER I 63 O LYS I 74 SHEET 1 AD1 5 SER I 10 THR I 14 0 SHEET 2 AD1 5 THR I 102 LYS I 107 1 O LYS I 103 N LEU I 11 SHEET 3 AD1 5 GLY I 84 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AD1 5 LEU I 33 GLN I 38 -1 N SER I 34 O MET I 89 SHEET 5 AD1 5 ARG I 45 TYR I 49 -1 O LEU I 47 N TRP I 35 SHEET 1 AD2 4 SER I 10 THR I 14 0 SHEET 2 AD2 4 THR I 102 LYS I 107 1 O LYS I 103 N LEU I 11 SHEET 3 AD2 4 GLY I 84 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AD2 4 THR I 97 PHE I 98 -1 O THR I 97 N GLN I 90 SHEET 1 AD3 5 SER E1032 ALA E1036 0 SHEET 2 AD3 5 TYR E1022 GLN E1027 -1 N HIS E1026 O GLY E1033 SHEET 3 AD3 5 THR E 12 TYR E 17 -1 N THR E 12 O GLN E1027 SHEET 4 AD3 5 CYS E1137 PHE E1140 -1 O PHE E1138 N ILE E 13 SHEET 5 AD3 5 ALA E1130 GLU E1132 -1 N LYS E1131 O GLU E1139 SHEET 1 AD4 2 ASP E 24 VAL E 26 0 SHEET 2 AD4 2 VAL E 34 VAL E 36 -1 O VAL E 34 N VAL E 26 SHEET 1 AD5 2 SER E 39 ASN E 41 0 SHEET 2 AD5 2 ARG E 322 VAL E 324 -1 O MET E 323 N VAL E 40 SHEET 1 AD6 3 LEU E 43 GLU E 44 0 SHEET 2 AD6 3 PHE E 301 GLN E 302 1 O PHE E 301 N GLU E 44 SHEET 3 AD6 3 LYS E 314 TYR E 315 1 O LYS E 314 N GLN E 302 SHEET 1 AD7 3 LEU E 60 GLN E 61 0 SHEET 2 AD7 3 ILE E 89 GLU E 91 1 O ALA E 90 N LEU E 60 SHEET 3 AD7 3 ILE E 274 THR E 276 1 O ILE E 275 N GLU E 91 SHEET 1 AD8 6 ARG E 84 SER E 85 0 SHEET 2 AD8 6 VAL E 118 GLU E 125 -1 O PHE E 121 N ARG E 84 SHEET 3 AD8 6 TYR E 262 ARG E 268 -1 O SER E 267 N SER E 119 SHEET 4 AD8 6 VAL E 182 HIS E 190 -1 N LEU E 183 O PHE E 264 SHEET 5 AD8 6 LEU E 257 PRO E 260 -1 O ILE E 258 N GLY E 187 SHEET 6 AD8 6 LEU E 157 TRP E 159 -1 N VAL E 158 O ALA E 259 SHEET 1 AD9 5 ARG E 84 SER E 85 0 SHEET 2 AD9 5 VAL E 118 GLU E 125 -1 O PHE E 121 N ARG E 84 SHEET 3 AD9 5 TYR E 262 ARG E 268 -1 O SER E 267 N SER E 119 SHEET 4 AD9 5 VAL E 182 HIS E 190 -1 N LEU E 183 O PHE E 264 SHEET 5 AD9 5 ARG E 235 LEU E 243 -1 O ARG E 235 N HIS E 190 SHEET 1 AE1 4 LEU E 170 VAL E 175 0 SHEET 2 AE1 4 THR E 248 ALA E 253 -1 O PHE E 251 N ARG E 172 SHEET 3 AE1 4 VAL E 208 SER E 212 -1 N SER E 209 O GLU E 252 SHEET 4 AE1 4 ASN E 216 PHE E 219 -1 O PHE E 219 N VAL E 208 SHEET 1 AE2 3 ALA E 294 ILE E 295 0 SHEET 2 AE2 3 CYS E 288 GLN E 289 -1 N CYS E 288 O ILE E 295 SHEET 3 AE2 3 ILE E 309 GLY E 310 -1 O ILE E 309 N GLN E 289 SHEET 1 AE3 4 GLN J 3 SER J 7 0 SHEET 2 AE3 4 LEU J 18 SER J 25 -1 O SER J 25 N GLN J 3 SHEET 3 AE3 4 GLN J 77 LEU J 82 -1 O LEU J 82 N LEU J 18 SHEET 4 AE3 4 VAL J 67 ASP J 72 -1 N SER J 70 O SER J 79 SHEET 1 AE4 6 LEU J 11 VAL J 12 0 SHEET 2 AE4 6 ALA J 107 VAL J 111 1 O THR J 110 N VAL J 12 SHEET 3 AE4 6 ALA J 88 ARG J 96 -1 N TYR J 90 O ALA J 107 SHEET 4 AE4 6 TYR J 32 GLN J 39 -1 N GLN J 39 O VAL J 89 SHEET 5 AE4 6 GLU J 46 ILE J 51 -1 O GLU J 46 N ARG J 38 SHEET 6 AE4 6 THR J 57 SER J 59 -1 O LYS J 58 N ARG J 50 SHEET 1 AE5 4 MET K 4 SER K 7 0 SHEET 2 AE5 4 ALA K 19 SER K 25 -1 O SER K 22 N SER K 7 SHEET 3 AE5 4 ASP K 70 ILE K 75 -1 O ILE K 75 N ALA K 19 SHEET 4 AE5 4 PHE K 62 SER K 67 -1 N SER K 63 O LYS K 74 SHEET 1 AE6 5 SER K 10 THR K 14 0 SHEET 2 AE6 5 THR K 102 LYS K 107 1 O LYS K 103 N LEU K 11 SHEET 3 AE6 5 GLY K 84 GLN K 90 -1 N GLY K 84 O VAL K 104 SHEET 4 AE6 5 LEU K 33 GLN K 38 -1 N GLN K 38 O VAL K 85 SHEET 5 AE6 5 ARG K 45 TYR K 49 -1 O LEU K 47 N TRP K 35 SHEET 1 AE7 4 SER K 10 THR K 14 0 SHEET 2 AE7 4 THR K 102 LYS K 107 1 O LYS K 103 N LEU K 11 SHEET 3 AE7 4 GLY K 84 GLN K 90 -1 N GLY K 84 O VAL K 104 SHEET 4 AE7 4 THR K 97 PHE K 98 -1 O THR K 97 N GLN K 90 SSBOND 1 CYS A 14 CYS A 1137 1555 1555 2.03 SSBOND 2 CYS A 30 CYS C 1047 1555 1555 2.04 SSBOND 3 CYS A 52 CYS A 284 1555 1555 2.02 SSBOND 4 CYS A 65 CYS A 77 1555 1555 2.03 SSBOND 5 CYS A 100 CYS A 145 1555 1555 2.03 SSBOND 6 CYS A 288 CYS A 312 1555 1555 2.03 SSBOND 7 CYS A 1047 CYS E 30 1555 1555 2.04 SSBOND 8 CYS A 1144 CYS A 1148 1555 1555 2.03 SSBOND 9 CYS H 22 CYS H 92 1555 1555 2.04 SSBOND 10 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 11 CYS C 14 CYS C 1137 1555 1555 2.03 SSBOND 12 CYS C 30 CYS E 1047 1555 1555 2.03 SSBOND 13 CYS C 52 CYS C 284 1555 1555 2.02 SSBOND 14 CYS C 65 CYS C 77 1555 1555 2.02 SSBOND 15 CYS C 100 CYS C 145 1555 1555 2.03 SSBOND 16 CYS C 288 CYS C 312 1555 1555 2.02 SSBOND 17 CYS C 1144 CYS C 1148 1555 1555 2.03 SSBOND 18 CYS G 22 CYS G 92 1555 1555 2.04 SSBOND 19 CYS I 23 CYS I 88 1555 1555 2.04 SSBOND 20 CYS E 14 CYS E 1137 1555 1555 2.03 SSBOND 21 CYS E 52 CYS E 284 1555 1555 2.02 SSBOND 22 CYS E 65 CYS E 77 1555 1555 2.02 SSBOND 23 CYS E 100 CYS E 145 1555 1555 2.03 SSBOND 24 CYS E 288 CYS E 312 1555 1555 2.02 SSBOND 25 CYS E 1144 CYS E 1148 1555 1555 2.03 SSBOND 26 CYS J 22 CYS J 92 1555 1555 2.04 SSBOND 27 CYS K 23 CYS K 88 1555 1555 2.04 LINK ND2 ASN A 21 C1 NAG A2001 1555 1555 1.44 LINK ND2 ASN A 33 C1 NAG A2002 1555 1555 1.44 LINK ND2 ASN A 83 C1 NAG N 1 1555 1555 1.43 LINK ND2 ASN A 97 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN A 135 C1 NAG A2003 1555 1555 1.44 LINK ND2 ASN A 169 C1 NAG O 1 1555 1555 1.45 LINK ND2 ASN A 296 C1 NAG A2004 1555 1555 1.45 LINK ND2 ASN A1154 C1 NAG A2005 1555 1555 1.44 LINK ND2 ASN C 21 C1 NAG C2005 1555 1555 1.44 LINK ND2 ASN C 33 C1 NAG C2001 1555 1555 1.44 LINK ND2 ASN C 83 C1 NAG C2002 1555 1555 1.44 LINK ND2 ASN C 97 C1 NAG P 1 1555 1555 1.43 LINK ND2 ASN C 135 C1 NAG C2003 1555 1555 1.44 LINK ND2 ASN C 169 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN C 296 C1 NAG C2004 1555 1555 1.46 LINK ND2 ASN C1154 C1 NAG C2006 1555 1555 1.44 LINK ND2 ASN E 21 C1 NAG E2004 1555 1555 1.48 LINK ND2 ASN E 33 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN E 83 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN E 97 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN E 135 C1 NAG E2002 1555 1555 1.44 LINK ND2 ASN E 164 C1 NAG E2001 1555 1555 1.44 LINK ND2 ASN E 169 C1 NAG U 1 1555 1555 1.47 LINK ND2 ASN E 296 C1 NAG E2003 1555 1555 1.46 LINK ND2 ASN E1154 C1 NAG E2005 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.45 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.45 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.44 LINK O3 BMA O 3 C1 MAN O 4 1555 1555 1.44 LINK O6 BMA O 3 C1 MAN O 6 1555 1555 1.44 LINK O2 MAN O 4 C1 MAN O 5 1555 1555 1.44 LINK O6 MAN O 6 C1 MAN O 7 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.45 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG Q 2 C1 BMA Q 3 1555 1555 1.46 LINK O3 BMA Q 3 C1 MAN Q 4 1555 1555 1.46 LINK O6 BMA Q 3 C1 MAN Q 6 1555 1555 1.44 LINK O2 MAN Q 4 C1 MAN Q 5 1555 1555 1.44 LINK O6 MAN Q 6 C1 MAN Q 7 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.46 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.45 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.46 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.45 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.46 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.44 LINK O6 BMA U 3 C1 MAN U 6 1555 1555 1.47 LINK O2 MAN U 4 C1 MAN U 5 1555 1555 1.44 LINK O6 MAN U 6 C1 MAN U 7 1555 1555 1.44 CISPEP 1 SER L 7 PRO L 8 0 -5.15 CISPEP 2 TRP L 94 PRO L 95 0 -5.07 CISPEP 3 SER I 7 PRO I 8 0 -4.71 CISPEP 4 TRP I 94 PRO I 95 0 -5.91 CISPEP 5 SER K 7 PRO K 8 0 -4.83 CISPEP 6 TRP K 94 PRO K 95 0 -4.76 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000