HEADER VIRAL PROTEIN 16-JAN-24 8VPF TITLE STRUCTURE OF SARS-COV SPIKE IN COMPLEX WITH COV1-65 FAB (NTD-BOUND) COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: COV1-65 ANTIBODY HEAVY CHAIN; COMPND 8 CHAIN: M, D, E; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: COV1-65 ANTIBODY LIGHT CHAIN; COMPND 12 CHAIN: N, F, G; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; SOURCE 3 ORGANISM_TAXID: 2901879; SOURCE 4 GENE: S, 2; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: 293F; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 11 ORGANISM_COMMON: HUMAN; SOURCE 12 ORGANISM_TAXID: 9606; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 EXPRESSION_SYSTEM_CELL_LINE: 293F; SOURCE 17 MOL_ID: 3; SOURCE 18 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 19 ORGANISM_COMMON: HUMAN; SOURCE 20 ORGANISM_TAXID: 9606; SOURCE 21 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 22 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 23 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 24 EXPRESSION_SYSTEM_CELL_LINE: 293F KEYWDS SARS-COV, SPIKE, MONOCLONAL ANTIBODY, COMPLEX, NTD, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR S.BANGARU,A.B.WARD REVDAT 1 19-MAR-25 8VPF 0 JRNL AUTH N.SURYADEVARA,N.KOSE,S.BANGARU,E.BINSHTEIN,J.MUNT, JRNL AUTH 2 D.R.MARTINEZ,A.SCHAFER,L.MYERS,T.D.SCOBEY,R.H.CARNAHAN, JRNL AUTH 3 A.B.WARD,R.S.BARIC,J.E.CROWE JR. JRNL TITL STRUCTURAL CHARACTERIZATION OF HUMAN MONOCLONAL ANTIBODIES JRNL TITL 2 TARGETING UNCOMMON ANTIGENIC SITES ON SPIKE GLYCOPROTEIN OF JRNL TITL 3 SARS-COV. JRNL REF J.CLIN.INVEST. V. 135 2024 JRNL REFN ISSN 0021-9738 JRNL PMID 39589795 JRNL DOI 10.1172/JCI178880 REMARK 2 REMARK 2 RESOLUTION. 3.20 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, LEGINON, GCTF, COOT, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, ROSETTA REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 6CRX REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.200 REMARK 3 NUMBER OF PARTICLES : 190300 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8VPF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-JAN-24. REMARK 100 THE DEPOSITION ID IS D_1000280214. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : STRUCTURE OF SARS-COV SPIKE IN REMARK 245 COMPLEX WITH COV1-65 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 2589 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 600.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1600.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 29000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, M, N, B, D, F, C, E, G, H, REMARK 350 AND CHAINS: I, J, K, L, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 PHE A 2 REMARK 465 ILE A 3 REMARK 465 PHE A 4 REMARK 465 LEU A 5 REMARK 465 LEU A 6 REMARK 465 PHE A 7 REMARK 465 LEU A 8 REMARK 465 THR A 9 REMARK 465 LEU A 10 REMARK 465 THR A 11 REMARK 465 SER A 12 REMARK 465 GLY A 13 REMARK 465 SER A 14 REMARK 465 ASP A 15 REMARK 465 LEU A 16 REMARK 465 ASP A 17 REMARK 465 ARG A 18 REMARK 465 CYS A 19 REMARK 465 THR A 20 REMARK 465 THR A 21 REMARK 465 PHE A 22 REMARK 465 ASP A 23 REMARK 465 ASP A 24 REMARK 465 VAL A 25 REMARK 465 GLN A 26 REMARK 465 ALA A 27 REMARK 465 PRO A 28 REMARK 465 ASN A 29 REMARK 465 ILE A 72 REMARK 465 ASN A 73 REMARK 465 HIS A 74 REMARK 465 THR A 75 REMARK 465 PHE A 76 REMARK 465 GLY A 77 REMARK 465 SER A 95 REMARK 465 SER A 105 REMARK 465 THR A 106 REMARK 465 MET A 107 REMARK 465 ASN A 108 REMARK 465 ASN A 109 REMARK 465 LYS A 110 REMARK 465 SER A 111 REMARK 465 GLN A 112 REMARK 465 SER A 113 REMARK 465 VAL A 114 REMARK 465 ILE A 115 REMARK 465 ILE A 116 REMARK 465 ILE A 117 REMARK 465 ASN A 118 REMARK 465 ASN A 119 REMARK 465 SER A 120 REMARK 465 THR A 121 REMARK 465 ASN A 122 REMARK 465 VAL A 123 REMARK 465 VAL A 124 REMARK 465 ILE A 125 REMARK 465 ARG A 126 REMARK 465 ALA A 127 REMARK 465 CYS A 128 REMARK 465 ASN A 129 REMARK 465 PHE A 130 REMARK 465 GLU A 131 REMARK 465 LEU A 132 REMARK 465 CYS A 133 REMARK 465 ASP A 134 REMARK 465 ASN A 135 REMARK 465 PRO A 136 REMARK 465 PHE A 137 REMARK 465 PHE A 138 REMARK 465 ALA A 139 REMARK 465 VAL A 140 REMARK 465 SER A 141 REMARK 465 LYS A 142 REMARK 465 PRO A 143 REMARK 465 MET A 144 REMARK 465 GLY A 145 REMARK 465 THR A 146 REMARK 465 GLN A 147 REMARK 465 THR A 148 REMARK 465 HIS A 149 REMARK 465 THR A 150 REMARK 465 MET A 151 REMARK 465 ILE A 152 REMARK 465 PHE A 153 REMARK 465 ASP A 154 REMARK 465 ASN A 155 REMARK 465 ALA A 156 REMARK 465 PHE A 157 REMARK 465 ASN A 158 REMARK 465 CYS A 159 REMARK 465 THR A 160 REMARK 465 PHE A 161 REMARK 465 GLU A 162 REMARK 465 TYR A 163 REMARK 465 ILE A 164 REMARK 465 SER A 165 REMARK 465 ASP A 166 REMARK 465 ALA A 167 REMARK 465 PHE A 168 REMARK 465 SER A 169 REMARK 465 LEU A 170 REMARK 465 ASP A 171 REMARK 465 VAL A 172 REMARK 465 SER A 173 REMARK 465 GLU A 174 REMARK 465 LYS A 175 REMARK 465 SER A 176 REMARK 465 GLY A 177 REMARK 465 ASN A 178 REMARK 465 PHE A 179 REMARK 465 LYS A 180 REMARK 465 HIS A 181 REMARK 465 PHE A 238 REMARK 465 SER A 239 REMARK 465 PRO A 240 REMARK 465 ALA A 241 REMARK 465 GLN A 242 REMARK 465 ASP A 243 REMARK 465 ILE A 244 REMARK 465 TRP A 245 REMARK 465 GLY A 246 REMARK 465 THR A 247 REMARK 465 SER A 248 REMARK 465 ALA A 249 REMARK 465 ALA A 250 REMARK 465 PHE A 316 REMARK 465 PRO A 317 REMARK 465 ASN A 318 REMARK 465 ILE A 319 REMARK 465 THR A 320 REMARK 465 ASN A 321 REMARK 465 LEU A 322 REMARK 465 CYS A 323 REMARK 465 PRO A 324 REMARK 465 PHE A 325 REMARK 465 GLY A 326 REMARK 465 GLU A 327 REMARK 465 VAL A 328 REMARK 465 PHE A 329 REMARK 465 ASN A 330 REMARK 465 ALA A 331 REMARK 465 THR A 332 REMARK 465 LYS A 333 REMARK 465 PHE A 334 REMARK 465 PRO A 335 REMARK 465 SER A 336 REMARK 465 VAL A 337 REMARK 465 TYR A 338 REMARK 465 ALA A 339 REMARK 465 TRP A 340 REMARK 465 GLU A 341 REMARK 465 ARG A 342 REMARK 465 LYS A 343 REMARK 465 LYS A 344 REMARK 465 ILE A 345 REMARK 465 SER A 346 REMARK 465 ASN A 347 REMARK 465 CYS A 348 REMARK 465 VAL A 349 REMARK 465 ALA A 350 REMARK 465 ASP A 351 REMARK 465 TYR A 352 REMARK 465 SER A 353 REMARK 465 VAL A 354 REMARK 465 LEU A 355 REMARK 465 TYR A 356 REMARK 465 ASN A 357 REMARK 465 SER A 358 REMARK 465 THR A 359 REMARK 465 PHE A 360 REMARK 465 PHE A 361 REMARK 465 SER A 362 REMARK 465 THR A 363 REMARK 465 PHE A 364 REMARK 465 LYS A 365 REMARK 465 CYS A 366 REMARK 465 TYR A 367 REMARK 465 GLY A 368 REMARK 465 VAL A 369 REMARK 465 SER A 370 REMARK 465 ALA A 371 REMARK 465 THR A 372 REMARK 465 LYS A 373 REMARK 465 LEU A 374 REMARK 465 ASN A 375 REMARK 465 ASP A 376 REMARK 465 LEU A 377 REMARK 465 CYS A 378 REMARK 465 PHE A 379 REMARK 465 SER A 380 REMARK 465 ASN A 381 REMARK 465 VAL A 382 REMARK 465 TYR A 383 REMARK 465 ALA A 384 REMARK 465 ASP A 385 REMARK 465 SER A 386 REMARK 465 PHE A 387 REMARK 465 VAL A 388 REMARK 465 VAL A 389 REMARK 465 LYS A 390 REMARK 465 GLY A 391 REMARK 465 ASP A 392 REMARK 465 ASP A 393 REMARK 465 VAL A 394 REMARK 465 ARG A 395 REMARK 465 GLN A 396 REMARK 465 ILE A 397 REMARK 465 ALA A 398 REMARK 465 PRO A 399 REMARK 465 GLY A 400 REMARK 465 GLN A 401 REMARK 465 THR A 402 REMARK 465 GLY A 403 REMARK 465 VAL A 404 REMARK 465 ILE A 405 REMARK 465 ALA A 406 REMARK 465 ASP A 407 REMARK 465 TYR A 408 REMARK 465 ASN A 409 REMARK 465 TYR A 410 REMARK 465 LYS A 411 REMARK 465 LEU A 412 REMARK 465 PRO A 413 REMARK 465 ASP A 414 REMARK 465 ASP A 415 REMARK 465 PHE A 416 REMARK 465 MET A 417 REMARK 465 GLY A 418 REMARK 465 CYS A 419 REMARK 465 VAL A 420 REMARK 465 LEU A 421 REMARK 465 ALA A 422 REMARK 465 TRP A 423 REMARK 465 ASN A 424 REMARK 465 THR A 425 REMARK 465 ARG A 426 REMARK 465 ASN A 427 REMARK 465 ILE A 428 REMARK 465 ASP A 429 REMARK 465 ALA A 430 REMARK 465 THR A 431 REMARK 465 SER A 432 REMARK 465 THR A 433 REMARK 465 GLY A 434 REMARK 465 ASN A 435 REMARK 465 TYR A 436 REMARK 465 ASN A 437 REMARK 465 TYR A 438 REMARK 465 LYS A 439 REMARK 465 TYR A 440 REMARK 465 ARG A 441 REMARK 465 TYR A 442 REMARK 465 LEU A 443 REMARK 465 ARG A 444 REMARK 465 HIS A 445 REMARK 465 GLY A 446 REMARK 465 LYS A 447 REMARK 465 LEU A 448 REMARK 465 ARG A 449 REMARK 465 PRO A 450 REMARK 465 PHE A 451 REMARK 465 GLU A 452 REMARK 465 ARG A 453 REMARK 465 ASP A 454 REMARK 465 ILE A 455 REMARK 465 SER A 456 REMARK 465 ASN A 457 REMARK 465 VAL A 458 REMARK 465 PRO A 459 REMARK 465 PHE A 460 REMARK 465 SER A 461 REMARK 465 PRO A 462 REMARK 465 ASP A 463 REMARK 465 GLY A 464 REMARK 465 LYS A 465 REMARK 465 PRO A 466 REMARK 465 CYS A 467 REMARK 465 THR A 468 REMARK 465 PRO A 469 REMARK 465 PRO A 470 REMARK 465 ALA A 471 REMARK 465 LEU A 472 REMARK 465 ASN A 473 REMARK 465 CYS A 474 REMARK 465 TYR A 475 REMARK 465 TRP A 476 REMARK 465 PRO A 477 REMARK 465 LEU A 478 REMARK 465 ASN A 479 REMARK 465 ASP A 480 REMARK 465 TYR A 481 REMARK 465 GLY A 482 REMARK 465 PHE A 483 REMARK 465 TYR A 484 REMARK 465 THR A 485 REMARK 465 THR A 486 REMARK 465 THR A 487 REMARK 465 GLY A 488 REMARK 465 ILE A 489 REMARK 465 GLY A 490 REMARK 465 TYR A 491 REMARK 465 GLN A 492 REMARK 465 PRO A 493 REMARK 465 TYR A 494 REMARK 465 ARG A 495 REMARK 465 VAL A 496 REMARK 465 VAL A 497 REMARK 465 VAL A 498 REMARK 465 LEU A 499 REMARK 465 SER A 500 REMARK 465 PHE A 501 REMARK 465 GLU A 502 REMARK 465 LEU A 503 REMARK 465 LEU A 504 REMARK 465 ASN A 505 REMARK 465 ALA A 506 REMARK 465 PRO A 507 REMARK 465 ALA A 508 REMARK 465 THR A 509 REMARK 465 VAL A 510 REMARK 465 CYS A 511 REMARK 465 GLY A 512 REMARK 465 PRO A 513 REMARK 465 LYS A 514 REMARK 465 SER A 664 REMARK 465 LEU A 665 REMARK 465 LEU A 666 REMARK 465 ARG A 667 REMARK 465 SER A 668 REMARK 465 THR A 669 REMARK 465 SER A 670 REMARK 465 GLN A 671 REMARK 465 LEU A 810 REMARK 465 ALA A 811 REMARK 465 ASP A 812 REMARK 465 ALA A 813 REMARK 465 GLY A 814 REMARK 465 PHE A 815 REMARK 465 MET A 816 REMARK 465 LYS A 817 REMARK 465 GLN A 818 REMARK 465 TYR A 819 REMARK 465 ASP A 825 REMARK 465 ILE A 826 REMARK 465 ASN A 827 REMARK 465 ALA A 828 REMARK 465 ARG A 829 REMARK 465 ASP A 830 REMARK 465 GLU A 1126 REMARK 465 LEU A 1127 REMARK 465 ASP A 1128 REMARK 465 SER A 1129 REMARK 465 PHE A 1130 REMARK 465 LYS A 1131 REMARK 465 GLU A 1132 REMARK 465 GLU A 1133 REMARK 465 LEU A 1134 REMARK 465 ASP A 1135 REMARK 465 LYS A 1136 REMARK 465 TYR A 1137 REMARK 465 PHE A 1138 REMARK 465 LYS A 1139 REMARK 465 ASN A 1140 REMARK 465 HIS A 1141 REMARK 465 THR A 1142 REMARK 465 SER A 1143 REMARK 465 PRO A 1144 REMARK 465 ASP A 1145 REMARK 465 VAL A 1146 REMARK 465 ASP A 1147 REMARK 465 LEU A 1148 REMARK 465 GLY A 1149 REMARK 465 ASP A 1150 REMARK 465 ILE A 1151 REMARK 465 SER A 1152 REMARK 465 GLY A 1153 REMARK 465 ILE A 1154 REMARK 465 ASN A 1155 REMARK 465 ALA A 1156 REMARK 465 SER A 1157 REMARK 465 VAL A 1158 REMARK 465 VAL A 1159 REMARK 465 ASN A 1160 REMARK 465 ILE A 1161 REMARK 465 GLN A 1162 REMARK 465 LYS A 1163 REMARK 465 GLU A 1164 REMARK 465 ILE A 1165 REMARK 465 ASP A 1166 REMARK 465 ARG A 1167 REMARK 465 LEU A 1168 REMARK 465 ASN A 1169 REMARK 465 GLU A 1170 REMARK 465 VAL A 1171 REMARK 465 ALA A 1172 REMARK 465 LYS A 1173 REMARK 465 ASN A 1174 REMARK 465 LEU A 1175 REMARK 465 ASN A 1176 REMARK 465 GLU A 1177 REMARK 465 SER A 1178 REMARK 465 LEU A 1179 REMARK 465 ILE A 1180 REMARK 465 ASP A 1181 REMARK 465 LEU A 1182 REMARK 465 GLN A 1183 REMARK 465 GLU A 1184 REMARK 465 LEU A 1185 REMARK 465 GLY A 1186 REMARK 465 LYS A 1187 REMARK 465 TYR A 1188 REMARK 465 GLU A 1189 REMARK 465 GLN A 1190 REMARK 465 GLY A 1191 REMARK 465 SER A 1192 REMARK 465 GLY A 1193 REMARK 465 TYR A 1194 REMARK 465 ILE A 1195 REMARK 465 PRO A 1196 REMARK 465 GLU A 1197 REMARK 465 ALA A 1198 REMARK 465 PRO A 1199 REMARK 465 ARG A 1200 REMARK 465 ASP A 1201 REMARK 465 GLY A 1202 REMARK 465 GLN A 1203 REMARK 465 ALA A 1204 REMARK 465 TYR A 1205 REMARK 465 VAL A 1206 REMARK 465 ARG A 1207 REMARK 465 LYS A 1208 REMARK 465 ASP A 1209 REMARK 465 GLY A 1210 REMARK 465 GLU A 1211 REMARK 465 TRP A 1212 REMARK 465 VAL A 1213 REMARK 465 LEU A 1214 REMARK 465 LEU A 1215 REMARK 465 SER A 1216 REMARK 465 THR A 1217 REMARK 465 PHE A 1218 REMARK 465 LEU A 1219 REMARK 465 GLY A 1220 REMARK 465 ARG A 1221 REMARK 465 SER A 1222 REMARK 465 LEU A 1223 REMARK 465 GLU A 1224 REMARK 465 VAL A 1225 REMARK 465 LEU A 1226 REMARK 465 PHE A 1227 REMARK 465 GLN A 1228 REMARK 465 GLY A 1229 REMARK 465 PRO A 1230 REMARK 465 GLY A 1231 REMARK 465 HIS A 1232 REMARK 465 HIS A 1233 REMARK 465 HIS A 1234 REMARK 465 HIS A 1235 REMARK 465 HIS A 1236 REMARK 465 HIS A 1237 REMARK 465 HIS A 1238 REMARK 465 HIS A 1239 REMARK 465 SER A 1240 REMARK 465 ALA A 1241 REMARK 465 TRP A 1242 REMARK 465 SER A 1243 REMARK 465 HIS A 1244 REMARK 465 PRO A 1245 REMARK 465 GLN A 1246 REMARK 465 PHE A 1247 REMARK 465 GLU A 1248 REMARK 465 LYS A 1249 REMARK 465 GLN M 1 REMARK 465 SER M 128 REMARK 465 ALA M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 LYS M 132 REMARK 465 GLY M 133 REMARK 465 PRO M 134 REMARK 465 SER M 135 REMARK 465 VAL M 136 REMARK 465 PHE M 137 REMARK 465 PRO M 138 REMARK 465 LEU M 139 REMARK 465 ALA M 140 REMARK 465 PRO M 141 REMARK 465 SER M 142 REMARK 465 SER M 143 REMARK 465 LYS M 144 REMARK 465 SER M 145 REMARK 465 THR M 146 REMARK 465 SER M 147 REMARK 465 GLY M 148 REMARK 465 GLY M 149 REMARK 465 THR M 150 REMARK 465 ALA M 151 REMARK 465 ALA M 152 REMARK 465 LEU M 153 REMARK 465 GLY M 154 REMARK 465 CYS M 155 REMARK 465 LEU M 156 REMARK 465 VAL M 157 REMARK 465 LYS M 158 REMARK 465 ASP M 159 REMARK 465 TYR M 160 REMARK 465 PHE M 161 REMARK 465 PRO M 162 REMARK 465 GLU M 163 REMARK 465 PRO M 164 REMARK 465 VAL M 165 REMARK 465 THR M 166 REMARK 465 VAL M 167 REMARK 465 SER M 168 REMARK 465 TRP M 169 REMARK 465 ASN M 170 REMARK 465 SER M 171 REMARK 465 GLY M 172 REMARK 465 ALA M 173 REMARK 465 LEU M 174 REMARK 465 THR M 175 REMARK 465 SER M 176 REMARK 465 GLY M 177 REMARK 465 VAL M 178 REMARK 465 HIS M 179 REMARK 465 THR M 180 REMARK 465 PHE M 181 REMARK 465 PRO M 182 REMARK 465 ALA M 183 REMARK 465 VAL M 184 REMARK 465 LEU M 185 REMARK 465 GLN M 186 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 GLY M 189 REMARK 465 LEU M 190 REMARK 465 TYR M 191 REMARK 465 SER M 192 REMARK 465 LEU M 193 REMARK 465 SER M 194 REMARK 465 SER M 195 REMARK 465 VAL M 196 REMARK 465 VAL M 197 REMARK 465 THR M 198 REMARK 465 VAL M 199 REMARK 465 PRO M 200 REMARK 465 SER M 201 REMARK 465 SER M 202 REMARK 465 SER M 203 REMARK 465 LEU M 204 REMARK 465 GLY M 205 REMARK 465 THR M 206 REMARK 465 GLN M 207 REMARK 465 THR M 208 REMARK 465 TYR M 209 REMARK 465 ILE M 210 REMARK 465 CYS M 211 REMARK 465 ASN M 212 REMARK 465 VAL M 213 REMARK 465 ASN M 214 REMARK 465 HIS M 215 REMARK 465 LYS M 216 REMARK 465 PRO M 217 REMARK 465 SER M 218 REMARK 465 ASN M 219 REMARK 465 THR M 220 REMARK 465 LYS M 221 REMARK 465 VAL M 222 REMARK 465 ASP M 223 REMARK 465 LYS M 224 REMARK 465 LYS M 225 REMARK 465 VAL M 226 REMARK 465 GLU M 227 REMARK 465 PRO M 228 REMARK 465 LYS M 229 REMARK 465 SER M 230 REMARK 465 CYS M 231 REMARK 465 GLN N 1 REMARK 465 SER N 2 REMARK 465 ALA N 3 REMARK 465 LEU N 111 REMARK 465 GLY N 112 REMARK 465 GLN N 113 REMARK 465 PRO N 114 REMARK 465 LYS N 115 REMARK 465 ALA N 116 REMARK 465 ALA N 117 REMARK 465 PRO N 118 REMARK 465 SER N 119 REMARK 465 VAL N 120 REMARK 465 THR N 121 REMARK 465 LEU N 122 REMARK 465 PHE N 123 REMARK 465 PRO N 124 REMARK 465 PRO N 125 REMARK 465 SER N 126 REMARK 465 SER N 127 REMARK 465 GLU N 128 REMARK 465 GLU N 129 REMARK 465 LEU N 130 REMARK 465 GLN N 131 REMARK 465 ALA N 132 REMARK 465 ASN N 133 REMARK 465 LYS N 134 REMARK 465 ALA N 135 REMARK 465 THR N 136 REMARK 465 LEU N 137 REMARK 465 VAL N 138 REMARK 465 CYS N 139 REMARK 465 LEU N 140 REMARK 465 ILE N 141 REMARK 465 SER N 142 REMARK 465 ASP N 143 REMARK 465 PHE N 144 REMARK 465 TYR N 145 REMARK 465 PRO N 146 REMARK 465 GLY N 147 REMARK 465 ALA N 148 REMARK 465 VAL N 149 REMARK 465 THR N 150 REMARK 465 VAL N 151 REMARK 465 ALA N 152 REMARK 465 TRP N 153 REMARK 465 LYS N 154 REMARK 465 ALA N 155 REMARK 465 ASP N 156 REMARK 465 SER N 157 REMARK 465 SER N 158 REMARK 465 PRO N 159 REMARK 465 VAL N 160 REMARK 465 LYS N 161 REMARK 465 ALA N 162 REMARK 465 GLY N 163 REMARK 465 VAL N 164 REMARK 465 GLU N 165 REMARK 465 THR N 166 REMARK 465 THR N 167 REMARK 465 THR N 168 REMARK 465 PRO N 169 REMARK 465 SER N 170 REMARK 465 LYS N 171 REMARK 465 GLN N 172 REMARK 465 SER N 173 REMARK 465 ASN N 174 REMARK 465 ASN N 175 REMARK 465 LYS N 176 REMARK 465 TYR N 177 REMARK 465 ALA N 178 REMARK 465 ALA N 179 REMARK 465 SER N 180 REMARK 465 SER N 181 REMARK 465 TYR N 182 REMARK 465 LEU N 183 REMARK 465 SER N 184 REMARK 465 LEU N 185 REMARK 465 THR N 186 REMARK 465 PRO N 187 REMARK 465 GLU N 188 REMARK 465 GLN N 189 REMARK 465 TRP N 190 REMARK 465 LYS N 191 REMARK 465 SER N 192 REMARK 465 HIS N 193 REMARK 465 ARG N 194 REMARK 465 SER N 195 REMARK 465 TYR N 196 REMARK 465 SER N 197 REMARK 465 CYS N 198 REMARK 465 GLN N 199 REMARK 465 VAL N 200 REMARK 465 THR N 201 REMARK 465 HIS N 202 REMARK 465 GLU N 203 REMARK 465 GLY N 204 REMARK 465 SER N 205 REMARK 465 THR N 206 REMARK 465 VAL N 207 REMARK 465 GLU N 208 REMARK 465 LYS N 209 REMARK 465 THR N 210 REMARK 465 VAL N 211 REMARK 465 ALA N 212 REMARK 465 PRO N 213 REMARK 465 THR N 214 REMARK 465 GLU N 215 REMARK 465 CYS N 216 REMARK 465 SER N 217 REMARK 465 MET B 1 REMARK 465 PHE B 2 REMARK 465 ILE B 3 REMARK 465 PHE B 4 REMARK 465 LEU B 5 REMARK 465 LEU B 6 REMARK 465 PHE B 7 REMARK 465 LEU B 8 REMARK 465 THR B 9 REMARK 465 LEU B 10 REMARK 465 THR B 11 REMARK 465 SER B 12 REMARK 465 GLY B 13 REMARK 465 SER B 14 REMARK 465 ASP B 15 REMARK 465 LEU B 16 REMARK 465 ASP B 17 REMARK 465 ARG B 18 REMARK 465 CYS B 19 REMARK 465 THR B 20 REMARK 465 THR B 21 REMARK 465 PHE B 22 REMARK 465 ASP B 23 REMARK 465 ASP B 24 REMARK 465 VAL B 25 REMARK 465 GLN B 26 REMARK 465 ALA B 27 REMARK 465 PRO B 28 REMARK 465 ASN B 29 REMARK 465 ILE B 72 REMARK 465 ASN B 73 REMARK 465 HIS B 74 REMARK 465 THR B 75 REMARK 465 PHE B 76 REMARK 465 GLY B 77 REMARK 465 SER B 95 REMARK 465 SER B 105 REMARK 465 THR B 106 REMARK 465 MET B 107 REMARK 465 ASN B 108 REMARK 465 ASN B 109 REMARK 465 LYS B 110 REMARK 465 SER B 111 REMARK 465 GLN B 112 REMARK 465 SER B 113 REMARK 465 VAL B 114 REMARK 465 ILE B 115 REMARK 465 ILE B 116 REMARK 465 ILE B 117 REMARK 465 ASN B 118 REMARK 465 ASN B 119 REMARK 465 SER B 120 REMARK 465 THR B 121 REMARK 465 ASN B 122 REMARK 465 VAL B 123 REMARK 465 VAL B 124 REMARK 465 ILE B 125 REMARK 465 ARG B 126 REMARK 465 ALA B 127 REMARK 465 CYS B 128 REMARK 465 ASN B 129 REMARK 465 PHE B 130 REMARK 465 GLU B 131 REMARK 465 LEU B 132 REMARK 465 CYS B 133 REMARK 465 ASP B 134 REMARK 465 ASN B 135 REMARK 465 PRO B 136 REMARK 465 PHE B 137 REMARK 465 PHE B 138 REMARK 465 ALA B 139 REMARK 465 VAL B 140 REMARK 465 SER B 141 REMARK 465 LYS B 142 REMARK 465 PRO B 143 REMARK 465 MET B 144 REMARK 465 GLY B 145 REMARK 465 THR B 146 REMARK 465 GLN B 147 REMARK 465 THR B 148 REMARK 465 HIS B 149 REMARK 465 THR B 150 REMARK 465 MET B 151 REMARK 465 ILE B 152 REMARK 465 PHE B 153 REMARK 465 ASP B 154 REMARK 465 ASN B 155 REMARK 465 ALA B 156 REMARK 465 PHE B 157 REMARK 465 ASN B 158 REMARK 465 CYS B 159 REMARK 465 THR B 160 REMARK 465 PHE B 161 REMARK 465 GLU B 162 REMARK 465 TYR B 163 REMARK 465 ILE B 164 REMARK 465 SER B 165 REMARK 465 ASP B 166 REMARK 465 ALA B 167 REMARK 465 PHE B 168 REMARK 465 SER B 169 REMARK 465 LEU B 170 REMARK 465 ASP B 171 REMARK 465 VAL B 172 REMARK 465 SER B 173 REMARK 465 GLU B 174 REMARK 465 LYS B 175 REMARK 465 SER B 176 REMARK 465 GLY B 177 REMARK 465 ASN B 178 REMARK 465 PHE B 179 REMARK 465 LYS B 180 REMARK 465 HIS B 181 REMARK 465 PHE B 238 REMARK 465 SER B 239 REMARK 465 PRO B 240 REMARK 465 ALA B 241 REMARK 465 GLN B 242 REMARK 465 ASP B 243 REMARK 465 ILE B 244 REMARK 465 TRP B 245 REMARK 465 GLY B 246 REMARK 465 THR B 247 REMARK 465 SER B 248 REMARK 465 ALA B 249 REMARK 465 ALA B 250 REMARK 465 PHE B 316 REMARK 465 PRO B 317 REMARK 465 ASN B 318 REMARK 465 ILE B 319 REMARK 465 THR B 320 REMARK 465 ASN B 321 REMARK 465 LEU B 322 REMARK 465 CYS B 323 REMARK 465 PRO B 324 REMARK 465 PHE B 325 REMARK 465 GLY B 326 REMARK 465 GLU B 327 REMARK 465 VAL B 328 REMARK 465 PHE B 329 REMARK 465 ASN B 330 REMARK 465 ALA B 331 REMARK 465 THR B 332 REMARK 465 LYS B 333 REMARK 465 PHE B 334 REMARK 465 PRO B 335 REMARK 465 SER B 336 REMARK 465 VAL B 337 REMARK 465 TYR B 338 REMARK 465 ALA B 339 REMARK 465 TRP B 340 REMARK 465 GLU B 341 REMARK 465 ARG B 342 REMARK 465 LYS B 343 REMARK 465 LYS B 344 REMARK 465 ILE B 345 REMARK 465 SER B 346 REMARK 465 ASN B 347 REMARK 465 CYS B 348 REMARK 465 VAL B 349 REMARK 465 ALA B 350 REMARK 465 ASP B 351 REMARK 465 TYR B 352 REMARK 465 SER B 353 REMARK 465 VAL B 354 REMARK 465 LEU B 355 REMARK 465 TYR B 356 REMARK 465 ASN B 357 REMARK 465 SER B 358 REMARK 465 THR B 359 REMARK 465 PHE B 360 REMARK 465 PHE B 361 REMARK 465 SER B 362 REMARK 465 THR B 363 REMARK 465 PHE B 364 REMARK 465 LYS B 365 REMARK 465 CYS B 366 REMARK 465 TYR B 367 REMARK 465 GLY B 368 REMARK 465 VAL B 369 REMARK 465 SER B 370 REMARK 465 ALA B 371 REMARK 465 THR B 372 REMARK 465 LYS B 373 REMARK 465 LEU B 374 REMARK 465 ASN B 375 REMARK 465 ASP B 376 REMARK 465 LEU B 377 REMARK 465 CYS B 378 REMARK 465 PHE B 379 REMARK 465 SER B 380 REMARK 465 ASN B 381 REMARK 465 VAL B 382 REMARK 465 TYR B 383 REMARK 465 ALA B 384 REMARK 465 ASP B 385 REMARK 465 SER B 386 REMARK 465 PHE B 387 REMARK 465 VAL B 388 REMARK 465 VAL B 389 REMARK 465 LYS B 390 REMARK 465 GLY B 391 REMARK 465 ASP B 392 REMARK 465 ASP B 393 REMARK 465 VAL B 394 REMARK 465 ARG B 395 REMARK 465 GLN B 396 REMARK 465 ILE B 397 REMARK 465 ALA B 398 REMARK 465 PRO B 399 REMARK 465 GLY B 400 REMARK 465 GLN B 401 REMARK 465 THR B 402 REMARK 465 GLY B 403 REMARK 465 VAL B 404 REMARK 465 ILE B 405 REMARK 465 ALA B 406 REMARK 465 ASP B 407 REMARK 465 TYR B 408 REMARK 465 ASN B 409 REMARK 465 TYR B 410 REMARK 465 LYS B 411 REMARK 465 LEU B 412 REMARK 465 PRO B 413 REMARK 465 ASP B 414 REMARK 465 ASP B 415 REMARK 465 PHE B 416 REMARK 465 MET B 417 REMARK 465 GLY B 418 REMARK 465 CYS B 419 REMARK 465 VAL B 420 REMARK 465 LEU B 421 REMARK 465 ALA B 422 REMARK 465 TRP B 423 REMARK 465 ASN B 424 REMARK 465 THR B 425 REMARK 465 ARG B 426 REMARK 465 ASN B 427 REMARK 465 ILE B 428 REMARK 465 ASP B 429 REMARK 465 ALA B 430 REMARK 465 THR B 431 REMARK 465 SER B 432 REMARK 465 THR B 433 REMARK 465 GLY B 434 REMARK 465 ASN B 435 REMARK 465 TYR B 436 REMARK 465 ASN B 437 REMARK 465 TYR B 438 REMARK 465 LYS B 439 REMARK 465 TYR B 440 REMARK 465 ARG B 441 REMARK 465 TYR B 442 REMARK 465 LEU B 443 REMARK 465 ARG B 444 REMARK 465 HIS B 445 REMARK 465 GLY B 446 REMARK 465 LYS B 447 REMARK 465 LEU B 448 REMARK 465 ARG B 449 REMARK 465 PRO B 450 REMARK 465 PHE B 451 REMARK 465 GLU B 452 REMARK 465 ARG B 453 REMARK 465 ASP B 454 REMARK 465 ILE B 455 REMARK 465 SER B 456 REMARK 465 ASN B 457 REMARK 465 VAL B 458 REMARK 465 PRO B 459 REMARK 465 PHE B 460 REMARK 465 SER B 461 REMARK 465 PRO B 462 REMARK 465 ASP B 463 REMARK 465 GLY B 464 REMARK 465 LYS B 465 REMARK 465 PRO B 466 REMARK 465 CYS B 467 REMARK 465 THR B 468 REMARK 465 PRO B 469 REMARK 465 PRO B 470 REMARK 465 ALA B 471 REMARK 465 LEU B 472 REMARK 465 ASN B 473 REMARK 465 CYS B 474 REMARK 465 TYR B 475 REMARK 465 TRP B 476 REMARK 465 PRO B 477 REMARK 465 LEU B 478 REMARK 465 ASN B 479 REMARK 465 ASP B 480 REMARK 465 TYR B 481 REMARK 465 GLY B 482 REMARK 465 PHE B 483 REMARK 465 TYR B 484 REMARK 465 THR B 485 REMARK 465 THR B 486 REMARK 465 THR B 487 REMARK 465 GLY B 488 REMARK 465 ILE B 489 REMARK 465 GLY B 490 REMARK 465 TYR B 491 REMARK 465 GLN B 492 REMARK 465 PRO B 493 REMARK 465 TYR B 494 REMARK 465 ARG B 495 REMARK 465 VAL B 496 REMARK 465 VAL B 497 REMARK 465 VAL B 498 REMARK 465 LEU B 499 REMARK 465 SER B 500 REMARK 465 PHE B 501 REMARK 465 GLU B 502 REMARK 465 LEU B 503 REMARK 465 LEU B 504 REMARK 465 ASN B 505 REMARK 465 ALA B 506 REMARK 465 PRO B 507 REMARK 465 ALA B 508 REMARK 465 THR B 509 REMARK 465 VAL B 510 REMARK 465 CYS B 511 REMARK 465 GLY B 512 REMARK 465 PRO B 513 REMARK 465 LYS B 514 REMARK 465 SER B 664 REMARK 465 LEU B 665 REMARK 465 LEU B 666 REMARK 465 ARG B 667 REMARK 465 SER B 668 REMARK 465 THR B 669 REMARK 465 SER B 670 REMARK 465 GLN B 671 REMARK 465 LEU B 810 REMARK 465 ALA B 811 REMARK 465 ASP B 812 REMARK 465 ALA B 813 REMARK 465 GLY B 814 REMARK 465 PHE B 815 REMARK 465 MET B 816 REMARK 465 LYS B 817 REMARK 465 GLN B 818 REMARK 465 TYR B 819 REMARK 465 ASP B 825 REMARK 465 ILE B 826 REMARK 465 ASN B 827 REMARK 465 ALA B 828 REMARK 465 ARG B 829 REMARK 465 ASP B 830 REMARK 465 GLU B 1126 REMARK 465 LEU B 1127 REMARK 465 ASP B 1128 REMARK 465 SER B 1129 REMARK 465 PHE B 1130 REMARK 465 LYS B 1131 REMARK 465 GLU B 1132 REMARK 465 GLU B 1133 REMARK 465 LEU B 1134 REMARK 465 ASP B 1135 REMARK 465 LYS B 1136 REMARK 465 TYR B 1137 REMARK 465 PHE B 1138 REMARK 465 LYS B 1139 REMARK 465 ASN B 1140 REMARK 465 HIS B 1141 REMARK 465 THR B 1142 REMARK 465 SER B 1143 REMARK 465 PRO B 1144 REMARK 465 ASP B 1145 REMARK 465 VAL B 1146 REMARK 465 ASP B 1147 REMARK 465 LEU B 1148 REMARK 465 GLY B 1149 REMARK 465 ASP B 1150 REMARK 465 ILE B 1151 REMARK 465 SER B 1152 REMARK 465 GLY B 1153 REMARK 465 ILE B 1154 REMARK 465 ASN B 1155 REMARK 465 ALA B 1156 REMARK 465 SER B 1157 REMARK 465 VAL B 1158 REMARK 465 VAL B 1159 REMARK 465 ASN B 1160 REMARK 465 ILE B 1161 REMARK 465 GLN B 1162 REMARK 465 LYS B 1163 REMARK 465 GLU B 1164 REMARK 465 ILE B 1165 REMARK 465 ASP B 1166 REMARK 465 ARG B 1167 REMARK 465 LEU B 1168 REMARK 465 ASN B 1169 REMARK 465 GLU B 1170 REMARK 465 VAL B 1171 REMARK 465 ALA B 1172 REMARK 465 LYS B 1173 REMARK 465 ASN B 1174 REMARK 465 LEU B 1175 REMARK 465 ASN B 1176 REMARK 465 GLU B 1177 REMARK 465 SER B 1178 REMARK 465 LEU B 1179 REMARK 465 ILE B 1180 REMARK 465 ASP B 1181 REMARK 465 LEU B 1182 REMARK 465 GLN B 1183 REMARK 465 GLU B 1184 REMARK 465 LEU B 1185 REMARK 465 GLY B 1186 REMARK 465 LYS B 1187 REMARK 465 TYR B 1188 REMARK 465 GLU B 1189 REMARK 465 GLN B 1190 REMARK 465 GLY B 1191 REMARK 465 SER B 1192 REMARK 465 GLY B 1193 REMARK 465 TYR B 1194 REMARK 465 ILE B 1195 REMARK 465 PRO B 1196 REMARK 465 GLU B 1197 REMARK 465 ALA B 1198 REMARK 465 PRO B 1199 REMARK 465 ARG B 1200 REMARK 465 ASP B 1201 REMARK 465 GLY B 1202 REMARK 465 GLN B 1203 REMARK 465 ALA B 1204 REMARK 465 TYR B 1205 REMARK 465 VAL B 1206 REMARK 465 ARG B 1207 REMARK 465 LYS B 1208 REMARK 465 ASP B 1209 REMARK 465 GLY B 1210 REMARK 465 GLU B 1211 REMARK 465 TRP B 1212 REMARK 465 VAL B 1213 REMARK 465 LEU B 1214 REMARK 465 LEU B 1215 REMARK 465 SER B 1216 REMARK 465 THR B 1217 REMARK 465 PHE B 1218 REMARK 465 LEU B 1219 REMARK 465 GLY B 1220 REMARK 465 ARG B 1221 REMARK 465 SER B 1222 REMARK 465 LEU B 1223 REMARK 465 GLU B 1224 REMARK 465 VAL B 1225 REMARK 465 LEU B 1226 REMARK 465 PHE B 1227 REMARK 465 GLN B 1228 REMARK 465 GLY B 1229 REMARK 465 PRO B 1230 REMARK 465 GLY B 1231 REMARK 465 HIS B 1232 REMARK 465 HIS B 1233 REMARK 465 HIS B 1234 REMARK 465 HIS B 1235 REMARK 465 HIS B 1236 REMARK 465 HIS B 1237 REMARK 465 HIS B 1238 REMARK 465 HIS B 1239 REMARK 465 SER B 1240 REMARK 465 ALA B 1241 REMARK 465 TRP B 1242 REMARK 465 SER B 1243 REMARK 465 HIS B 1244 REMARK 465 PRO B 1245 REMARK 465 GLN B 1246 REMARK 465 PHE B 1247 REMARK 465 GLU B 1248 REMARK 465 LYS B 1249 REMARK 465 GLN D 1 REMARK 465 SER D 128 REMARK 465 ALA D 129 REMARK 465 SER D 130 REMARK 465 THR D 131 REMARK 465 LYS D 132 REMARK 465 GLY D 133 REMARK 465 PRO D 134 REMARK 465 SER D 135 REMARK 465 VAL D 136 REMARK 465 PHE D 137 REMARK 465 PRO D 138 REMARK 465 LEU D 139 REMARK 465 ALA D 140 REMARK 465 PRO D 141 REMARK 465 SER D 142 REMARK 465 SER D 143 REMARK 465 LYS D 144 REMARK 465 SER D 145 REMARK 465 THR D 146 REMARK 465 SER D 147 REMARK 465 GLY D 148 REMARK 465 GLY D 149 REMARK 465 THR D 150 REMARK 465 ALA D 151 REMARK 465 ALA D 152 REMARK 465 LEU D 153 REMARK 465 GLY D 154 REMARK 465 CYS D 155 REMARK 465 LEU D 156 REMARK 465 VAL D 157 REMARK 465 LYS D 158 REMARK 465 ASP D 159 REMARK 465 TYR D 160 REMARK 465 PHE D 161 REMARK 465 PRO D 162 REMARK 465 GLU D 163 REMARK 465 PRO D 164 REMARK 465 VAL D 165 REMARK 465 THR D 166 REMARK 465 VAL D 167 REMARK 465 SER D 168 REMARK 465 TRP D 169 REMARK 465 ASN D 170 REMARK 465 SER D 171 REMARK 465 GLY D 172 REMARK 465 ALA D 173 REMARK 465 LEU D 174 REMARK 465 THR D 175 REMARK 465 SER D 176 REMARK 465 GLY D 177 REMARK 465 VAL D 178 REMARK 465 HIS D 179 REMARK 465 THR D 180 REMARK 465 PHE D 181 REMARK 465 PRO D 182 REMARK 465 ALA D 183 REMARK 465 VAL D 184 REMARK 465 LEU D 185 REMARK 465 GLN D 186 REMARK 465 SER D 187 REMARK 465 SER D 188 REMARK 465 GLY D 189 REMARK 465 LEU D 190 REMARK 465 TYR D 191 REMARK 465 SER D 192 REMARK 465 LEU D 193 REMARK 465 SER D 194 REMARK 465 SER D 195 REMARK 465 VAL D 196 REMARK 465 VAL D 197 REMARK 465 THR D 198 REMARK 465 VAL D 199 REMARK 465 PRO D 200 REMARK 465 SER D 201 REMARK 465 SER D 202 REMARK 465 SER D 203 REMARK 465 LEU D 204 REMARK 465 GLY D 205 REMARK 465 THR D 206 REMARK 465 GLN D 207 REMARK 465 THR D 208 REMARK 465 TYR D 209 REMARK 465 ILE D 210 REMARK 465 CYS D 211 REMARK 465 ASN D 212 REMARK 465 VAL D 213 REMARK 465 ASN D 214 REMARK 465 HIS D 215 REMARK 465 LYS D 216 REMARK 465 PRO D 217 REMARK 465 SER D 218 REMARK 465 ASN D 219 REMARK 465 THR D 220 REMARK 465 LYS D 221 REMARK 465 VAL D 222 REMARK 465 ASP D 223 REMARK 465 LYS D 224 REMARK 465 LYS D 225 REMARK 465 VAL D 226 REMARK 465 GLU D 227 REMARK 465 PRO D 228 REMARK 465 LYS D 229 REMARK 465 SER D 230 REMARK 465 CYS D 231 REMARK 465 GLN F 1 REMARK 465 SER F 2 REMARK 465 ALA F 3 REMARK 465 LEU F 111 REMARK 465 GLY F 112 REMARK 465 GLN F 113 REMARK 465 PRO F 114 REMARK 465 LYS F 115 REMARK 465 ALA F 116 REMARK 465 ALA F 117 REMARK 465 PRO F 118 REMARK 465 SER F 119 REMARK 465 VAL F 120 REMARK 465 THR F 121 REMARK 465 LEU F 122 REMARK 465 PHE F 123 REMARK 465 PRO F 124 REMARK 465 PRO F 125 REMARK 465 SER F 126 REMARK 465 SER F 127 REMARK 465 GLU F 128 REMARK 465 GLU F 129 REMARK 465 LEU F 130 REMARK 465 GLN F 131 REMARK 465 ALA F 132 REMARK 465 ASN F 133 REMARK 465 LYS F 134 REMARK 465 ALA F 135 REMARK 465 THR F 136 REMARK 465 LEU F 137 REMARK 465 VAL F 138 REMARK 465 CYS F 139 REMARK 465 LEU F 140 REMARK 465 ILE F 141 REMARK 465 SER F 142 REMARK 465 ASP F 143 REMARK 465 PHE F 144 REMARK 465 TYR F 145 REMARK 465 PRO F 146 REMARK 465 GLY F 147 REMARK 465 ALA F 148 REMARK 465 VAL F 149 REMARK 465 THR F 150 REMARK 465 VAL F 151 REMARK 465 ALA F 152 REMARK 465 TRP F 153 REMARK 465 LYS F 154 REMARK 465 ALA F 155 REMARK 465 ASP F 156 REMARK 465 SER F 157 REMARK 465 SER F 158 REMARK 465 PRO F 159 REMARK 465 VAL F 160 REMARK 465 LYS F 161 REMARK 465 ALA F 162 REMARK 465 GLY F 163 REMARK 465 VAL F 164 REMARK 465 GLU F 165 REMARK 465 THR F 166 REMARK 465 THR F 167 REMARK 465 THR F 168 REMARK 465 PRO F 169 REMARK 465 SER F 170 REMARK 465 LYS F 171 REMARK 465 GLN F 172 REMARK 465 SER F 173 REMARK 465 ASN F 174 REMARK 465 ASN F 175 REMARK 465 LYS F 176 REMARK 465 TYR F 177 REMARK 465 ALA F 178 REMARK 465 ALA F 179 REMARK 465 SER F 180 REMARK 465 SER F 181 REMARK 465 TYR F 182 REMARK 465 LEU F 183 REMARK 465 SER F 184 REMARK 465 LEU F 185 REMARK 465 THR F 186 REMARK 465 PRO F 187 REMARK 465 GLU F 188 REMARK 465 GLN F 189 REMARK 465 TRP F 190 REMARK 465 LYS F 191 REMARK 465 SER F 192 REMARK 465 HIS F 193 REMARK 465 ARG F 194 REMARK 465 SER F 195 REMARK 465 TYR F 196 REMARK 465 SER F 197 REMARK 465 CYS F 198 REMARK 465 GLN F 199 REMARK 465 VAL F 200 REMARK 465 THR F 201 REMARK 465 HIS F 202 REMARK 465 GLU F 203 REMARK 465 GLY F 204 REMARK 465 SER F 205 REMARK 465 THR F 206 REMARK 465 VAL F 207 REMARK 465 GLU F 208 REMARK 465 LYS F 209 REMARK 465 THR F 210 REMARK 465 VAL F 211 REMARK 465 ALA F 212 REMARK 465 PRO F 213 REMARK 465 THR F 214 REMARK 465 GLU F 215 REMARK 465 CYS F 216 REMARK 465 SER F 217 REMARK 465 MET C 1 REMARK 465 PHE C 2 REMARK 465 ILE C 3 REMARK 465 PHE C 4 REMARK 465 LEU C 5 REMARK 465 LEU C 6 REMARK 465 PHE C 7 REMARK 465 LEU C 8 REMARK 465 THR C 9 REMARK 465 LEU C 10 REMARK 465 THR C 11 REMARK 465 SER C 12 REMARK 465 GLY C 13 REMARK 465 SER C 14 REMARK 465 ASP C 15 REMARK 465 LEU C 16 REMARK 465 ASP C 17 REMARK 465 ARG C 18 REMARK 465 CYS C 19 REMARK 465 THR C 20 REMARK 465 THR C 21 REMARK 465 PHE C 22 REMARK 465 ASP C 23 REMARK 465 ASP C 24 REMARK 465 VAL C 25 REMARK 465 GLN C 26 REMARK 465 ALA C 27 REMARK 465 PRO C 28 REMARK 465 ASN C 29 REMARK 465 ILE C 72 REMARK 465 ASN C 73 REMARK 465 HIS C 74 REMARK 465 THR C 75 REMARK 465 PHE C 76 REMARK 465 GLY C 77 REMARK 465 SER C 95 REMARK 465 SER C 105 REMARK 465 THR C 106 REMARK 465 MET C 107 REMARK 465 ASN C 108 REMARK 465 ASN C 109 REMARK 465 LYS C 110 REMARK 465 SER C 111 REMARK 465 GLN C 112 REMARK 465 SER C 113 REMARK 465 VAL C 114 REMARK 465 ILE C 115 REMARK 465 ILE C 116 REMARK 465 ILE C 117 REMARK 465 ASN C 118 REMARK 465 ASN C 119 REMARK 465 SER C 120 REMARK 465 THR C 121 REMARK 465 ASN C 122 REMARK 465 VAL C 123 REMARK 465 VAL C 124 REMARK 465 ILE C 125 REMARK 465 ARG C 126 REMARK 465 ALA C 127 REMARK 465 CYS C 128 REMARK 465 ASN C 129 REMARK 465 PHE C 130 REMARK 465 GLU C 131 REMARK 465 LEU C 132 REMARK 465 CYS C 133 REMARK 465 ASP C 134 REMARK 465 ASN C 135 REMARK 465 PRO C 136 REMARK 465 PHE C 137 REMARK 465 PHE C 138 REMARK 465 ALA C 139 REMARK 465 VAL C 140 REMARK 465 SER C 141 REMARK 465 LYS C 142 REMARK 465 PRO C 143 REMARK 465 MET C 144 REMARK 465 GLY C 145 REMARK 465 THR C 146 REMARK 465 GLN C 147 REMARK 465 THR C 148 REMARK 465 HIS C 149 REMARK 465 THR C 150 REMARK 465 MET C 151 REMARK 465 ILE C 152 REMARK 465 PHE C 153 REMARK 465 ASP C 154 REMARK 465 ASN C 155 REMARK 465 ALA C 156 REMARK 465 PHE C 157 REMARK 465 ASN C 158 REMARK 465 CYS C 159 REMARK 465 THR C 160 REMARK 465 PHE C 161 REMARK 465 GLU C 162 REMARK 465 TYR C 163 REMARK 465 ILE C 164 REMARK 465 SER C 165 REMARK 465 ASP C 166 REMARK 465 ALA C 167 REMARK 465 PHE C 168 REMARK 465 SER C 169 REMARK 465 LEU C 170 REMARK 465 ASP C 171 REMARK 465 VAL C 172 REMARK 465 SER C 173 REMARK 465 GLU C 174 REMARK 465 LYS C 175 REMARK 465 SER C 176 REMARK 465 GLY C 177 REMARK 465 ASN C 178 REMARK 465 PHE C 179 REMARK 465 LYS C 180 REMARK 465 HIS C 181 REMARK 465 PHE C 238 REMARK 465 SER C 239 REMARK 465 PRO C 240 REMARK 465 ALA C 241 REMARK 465 GLN C 242 REMARK 465 ASP C 243 REMARK 465 ILE C 244 REMARK 465 TRP C 245 REMARK 465 GLY C 246 REMARK 465 THR C 247 REMARK 465 SER C 248 REMARK 465 ALA C 249 REMARK 465 ALA C 250 REMARK 465 PHE C 316 REMARK 465 PRO C 317 REMARK 465 ASN C 318 REMARK 465 ILE C 319 REMARK 465 THR C 320 REMARK 465 ASN C 321 REMARK 465 LEU C 322 REMARK 465 CYS C 323 REMARK 465 PRO C 324 REMARK 465 PHE C 325 REMARK 465 GLY C 326 REMARK 465 GLU C 327 REMARK 465 VAL C 328 REMARK 465 PHE C 329 REMARK 465 ASN C 330 REMARK 465 ALA C 331 REMARK 465 THR C 332 REMARK 465 LYS C 333 REMARK 465 PHE C 334 REMARK 465 PRO C 335 REMARK 465 SER C 336 REMARK 465 VAL C 337 REMARK 465 TYR C 338 REMARK 465 ALA C 339 REMARK 465 TRP C 340 REMARK 465 GLU C 341 REMARK 465 ARG C 342 REMARK 465 LYS C 343 REMARK 465 LYS C 344 REMARK 465 ILE C 345 REMARK 465 SER C 346 REMARK 465 ASN C 347 REMARK 465 CYS C 348 REMARK 465 VAL C 349 REMARK 465 ALA C 350 REMARK 465 ASP C 351 REMARK 465 TYR C 352 REMARK 465 SER C 353 REMARK 465 VAL C 354 REMARK 465 LEU C 355 REMARK 465 TYR C 356 REMARK 465 ASN C 357 REMARK 465 SER C 358 REMARK 465 THR C 359 REMARK 465 PHE C 360 REMARK 465 PHE C 361 REMARK 465 SER C 362 REMARK 465 THR C 363 REMARK 465 PHE C 364 REMARK 465 LYS C 365 REMARK 465 CYS C 366 REMARK 465 TYR C 367 REMARK 465 GLY C 368 REMARK 465 VAL C 369 REMARK 465 SER C 370 REMARK 465 ALA C 371 REMARK 465 THR C 372 REMARK 465 LYS C 373 REMARK 465 LEU C 374 REMARK 465 ASN C 375 REMARK 465 ASP C 376 REMARK 465 LEU C 377 REMARK 465 CYS C 378 REMARK 465 PHE C 379 REMARK 465 SER C 380 REMARK 465 ASN C 381 REMARK 465 VAL C 382 REMARK 465 TYR C 383 REMARK 465 ALA C 384 REMARK 465 ASP C 385 REMARK 465 SER C 386 REMARK 465 PHE C 387 REMARK 465 VAL C 388 REMARK 465 VAL C 389 REMARK 465 LYS C 390 REMARK 465 GLY C 391 REMARK 465 ASP C 392 REMARK 465 ASP C 393 REMARK 465 VAL C 394 REMARK 465 ARG C 395 REMARK 465 GLN C 396 REMARK 465 ILE C 397 REMARK 465 ALA C 398 REMARK 465 PRO C 399 REMARK 465 GLY C 400 REMARK 465 GLN C 401 REMARK 465 THR C 402 REMARK 465 GLY C 403 REMARK 465 VAL C 404 REMARK 465 ILE C 405 REMARK 465 ALA C 406 REMARK 465 ASP C 407 REMARK 465 TYR C 408 REMARK 465 ASN C 409 REMARK 465 TYR C 410 REMARK 465 LYS C 411 REMARK 465 LEU C 412 REMARK 465 PRO C 413 REMARK 465 ASP C 414 REMARK 465 ASP C 415 REMARK 465 PHE C 416 REMARK 465 MET C 417 REMARK 465 GLY C 418 REMARK 465 CYS C 419 REMARK 465 VAL C 420 REMARK 465 LEU C 421 REMARK 465 ALA C 422 REMARK 465 TRP C 423 REMARK 465 ASN C 424 REMARK 465 THR C 425 REMARK 465 ARG C 426 REMARK 465 ASN C 427 REMARK 465 ILE C 428 REMARK 465 ASP C 429 REMARK 465 ALA C 430 REMARK 465 THR C 431 REMARK 465 SER C 432 REMARK 465 THR C 433 REMARK 465 GLY C 434 REMARK 465 ASN C 435 REMARK 465 TYR C 436 REMARK 465 ASN C 437 REMARK 465 TYR C 438 REMARK 465 LYS C 439 REMARK 465 TYR C 440 REMARK 465 ARG C 441 REMARK 465 TYR C 442 REMARK 465 LEU C 443 REMARK 465 ARG C 444 REMARK 465 HIS C 445 REMARK 465 GLY C 446 REMARK 465 LYS C 447 REMARK 465 LEU C 448 REMARK 465 ARG C 449 REMARK 465 PRO C 450 REMARK 465 PHE C 451 REMARK 465 GLU C 452 REMARK 465 ARG C 453 REMARK 465 ASP C 454 REMARK 465 ILE C 455 REMARK 465 SER C 456 REMARK 465 ASN C 457 REMARK 465 VAL C 458 REMARK 465 PRO C 459 REMARK 465 PHE C 460 REMARK 465 SER C 461 REMARK 465 PRO C 462 REMARK 465 ASP C 463 REMARK 465 GLY C 464 REMARK 465 LYS C 465 REMARK 465 PRO C 466 REMARK 465 CYS C 467 REMARK 465 THR C 468 REMARK 465 PRO C 469 REMARK 465 PRO C 470 REMARK 465 ALA C 471 REMARK 465 LEU C 472 REMARK 465 ASN C 473 REMARK 465 CYS C 474 REMARK 465 TYR C 475 REMARK 465 TRP C 476 REMARK 465 PRO C 477 REMARK 465 LEU C 478 REMARK 465 ASN C 479 REMARK 465 ASP C 480 REMARK 465 TYR C 481 REMARK 465 GLY C 482 REMARK 465 PHE C 483 REMARK 465 TYR C 484 REMARK 465 THR C 485 REMARK 465 THR C 486 REMARK 465 THR C 487 REMARK 465 GLY C 488 REMARK 465 ILE C 489 REMARK 465 GLY C 490 REMARK 465 TYR C 491 REMARK 465 GLN C 492 REMARK 465 PRO C 493 REMARK 465 TYR C 494 REMARK 465 ARG C 495 REMARK 465 VAL C 496 REMARK 465 VAL C 497 REMARK 465 VAL C 498 REMARK 465 LEU C 499 REMARK 465 SER C 500 REMARK 465 PHE C 501 REMARK 465 GLU C 502 REMARK 465 LEU C 503 REMARK 465 LEU C 504 REMARK 465 ASN C 505 REMARK 465 ALA C 506 REMARK 465 PRO C 507 REMARK 465 ALA C 508 REMARK 465 THR C 509 REMARK 465 VAL C 510 REMARK 465 CYS C 511 REMARK 465 GLY C 512 REMARK 465 PRO C 513 REMARK 465 LYS C 514 REMARK 465 SER C 664 REMARK 465 LEU C 665 REMARK 465 LEU C 666 REMARK 465 ARG C 667 REMARK 465 SER C 668 REMARK 465 THR C 669 REMARK 465 SER C 670 REMARK 465 GLN C 671 REMARK 465 LEU C 810 REMARK 465 ALA C 811 REMARK 465 ASP C 812 REMARK 465 ALA C 813 REMARK 465 GLY C 814 REMARK 465 PHE C 815 REMARK 465 MET C 816 REMARK 465 LYS C 817 REMARK 465 GLN C 818 REMARK 465 TYR C 819 REMARK 465 ASP C 825 REMARK 465 ILE C 826 REMARK 465 ASN C 827 REMARK 465 ALA C 828 REMARK 465 ARG C 829 REMARK 465 ASP C 830 REMARK 465 GLU C 1126 REMARK 465 LEU C 1127 REMARK 465 ASP C 1128 REMARK 465 SER C 1129 REMARK 465 PHE C 1130 REMARK 465 LYS C 1131 REMARK 465 GLU C 1132 REMARK 465 GLU C 1133 REMARK 465 LEU C 1134 REMARK 465 ASP C 1135 REMARK 465 LYS C 1136 REMARK 465 TYR C 1137 REMARK 465 PHE C 1138 REMARK 465 LYS C 1139 REMARK 465 ASN C 1140 REMARK 465 HIS C 1141 REMARK 465 THR C 1142 REMARK 465 SER C 1143 REMARK 465 PRO C 1144 REMARK 465 ASP C 1145 REMARK 465 VAL C 1146 REMARK 465 ASP C 1147 REMARK 465 LEU C 1148 REMARK 465 GLY C 1149 REMARK 465 ASP C 1150 REMARK 465 ILE C 1151 REMARK 465 SER C 1152 REMARK 465 GLY C 1153 REMARK 465 ILE C 1154 REMARK 465 ASN C 1155 REMARK 465 ALA C 1156 REMARK 465 SER C 1157 REMARK 465 VAL C 1158 REMARK 465 VAL C 1159 REMARK 465 ASN C 1160 REMARK 465 ILE C 1161 REMARK 465 GLN C 1162 REMARK 465 LYS C 1163 REMARK 465 GLU C 1164 REMARK 465 ILE C 1165 REMARK 465 ASP C 1166 REMARK 465 ARG C 1167 REMARK 465 LEU C 1168 REMARK 465 ASN C 1169 REMARK 465 GLU C 1170 REMARK 465 VAL C 1171 REMARK 465 ALA C 1172 REMARK 465 LYS C 1173 REMARK 465 ASN C 1174 REMARK 465 LEU C 1175 REMARK 465 ASN C 1176 REMARK 465 GLU C 1177 REMARK 465 SER C 1178 REMARK 465 LEU C 1179 REMARK 465 ILE C 1180 REMARK 465 ASP C 1181 REMARK 465 LEU C 1182 REMARK 465 GLN C 1183 REMARK 465 GLU C 1184 REMARK 465 LEU C 1185 REMARK 465 GLY C 1186 REMARK 465 LYS C 1187 REMARK 465 TYR C 1188 REMARK 465 GLU C 1189 REMARK 465 GLN C 1190 REMARK 465 GLY C 1191 REMARK 465 SER C 1192 REMARK 465 GLY C 1193 REMARK 465 TYR C 1194 REMARK 465 ILE C 1195 REMARK 465 PRO C 1196 REMARK 465 GLU C 1197 REMARK 465 ALA C 1198 REMARK 465 PRO C 1199 REMARK 465 ARG C 1200 REMARK 465 ASP C 1201 REMARK 465 GLY C 1202 REMARK 465 GLN C 1203 REMARK 465 ALA C 1204 REMARK 465 TYR C 1205 REMARK 465 VAL C 1206 REMARK 465 ARG C 1207 REMARK 465 LYS C 1208 REMARK 465 ASP C 1209 REMARK 465 GLY C 1210 REMARK 465 GLU C 1211 REMARK 465 TRP C 1212 REMARK 465 VAL C 1213 REMARK 465 LEU C 1214 REMARK 465 LEU C 1215 REMARK 465 SER C 1216 REMARK 465 THR C 1217 REMARK 465 PHE C 1218 REMARK 465 LEU C 1219 REMARK 465 GLY C 1220 REMARK 465 ARG C 1221 REMARK 465 SER C 1222 REMARK 465 LEU C 1223 REMARK 465 GLU C 1224 REMARK 465 VAL C 1225 REMARK 465 LEU C 1226 REMARK 465 PHE C 1227 REMARK 465 GLN C 1228 REMARK 465 GLY C 1229 REMARK 465 PRO C 1230 REMARK 465 GLY C 1231 REMARK 465 HIS C 1232 REMARK 465 HIS C 1233 REMARK 465 HIS C 1234 REMARK 465 HIS C 1235 REMARK 465 HIS C 1236 REMARK 465 HIS C 1237 REMARK 465 HIS C 1238 REMARK 465 HIS C 1239 REMARK 465 SER C 1240 REMARK 465 ALA C 1241 REMARK 465 TRP C 1242 REMARK 465 SER C 1243 REMARK 465 HIS C 1244 REMARK 465 PRO C 1245 REMARK 465 GLN C 1246 REMARK 465 PHE C 1247 REMARK 465 GLU C 1248 REMARK 465 LYS C 1249 REMARK 465 GLN E 1 REMARK 465 SER E 128 REMARK 465 ALA E 129 REMARK 465 SER E 130 REMARK 465 THR E 131 REMARK 465 LYS E 132 REMARK 465 GLY E 133 REMARK 465 PRO E 134 REMARK 465 SER E 135 REMARK 465 VAL E 136 REMARK 465 PHE E 137 REMARK 465 PRO E 138 REMARK 465 LEU E 139 REMARK 465 ALA E 140 REMARK 465 PRO E 141 REMARK 465 SER E 142 REMARK 465 SER E 143 REMARK 465 LYS E 144 REMARK 465 SER E 145 REMARK 465 THR E 146 REMARK 465 SER E 147 REMARK 465 GLY E 148 REMARK 465 GLY E 149 REMARK 465 THR E 150 REMARK 465 ALA E 151 REMARK 465 ALA E 152 REMARK 465 LEU E 153 REMARK 465 GLY E 154 REMARK 465 CYS E 155 REMARK 465 LEU E 156 REMARK 465 VAL E 157 REMARK 465 LYS E 158 REMARK 465 ASP E 159 REMARK 465 TYR E 160 REMARK 465 PHE E 161 REMARK 465 PRO E 162 REMARK 465 GLU E 163 REMARK 465 PRO E 164 REMARK 465 VAL E 165 REMARK 465 THR E 166 REMARK 465 VAL E 167 REMARK 465 SER E 168 REMARK 465 TRP E 169 REMARK 465 ASN E 170 REMARK 465 SER E 171 REMARK 465 GLY E 172 REMARK 465 ALA E 173 REMARK 465 LEU E 174 REMARK 465 THR E 175 REMARK 465 SER E 176 REMARK 465 GLY E 177 REMARK 465 VAL E 178 REMARK 465 HIS E 179 REMARK 465 THR E 180 REMARK 465 PHE E 181 REMARK 465 PRO E 182 REMARK 465 ALA E 183 REMARK 465 VAL E 184 REMARK 465 LEU E 185 REMARK 465 GLN E 186 REMARK 465 SER E 187 REMARK 465 SER E 188 REMARK 465 GLY E 189 REMARK 465 LEU E 190 REMARK 465 TYR E 191 REMARK 465 SER E 192 REMARK 465 LEU E 193 REMARK 465 SER E 194 REMARK 465 SER E 195 REMARK 465 VAL E 196 REMARK 465 VAL E 197 REMARK 465 THR E 198 REMARK 465 VAL E 199 REMARK 465 PRO E 200 REMARK 465 SER E 201 REMARK 465 SER E 202 REMARK 465 SER E 203 REMARK 465 LEU E 204 REMARK 465 GLY E 205 REMARK 465 THR E 206 REMARK 465 GLN E 207 REMARK 465 THR E 208 REMARK 465 TYR E 209 REMARK 465 ILE E 210 REMARK 465 CYS E 211 REMARK 465 ASN E 212 REMARK 465 VAL E 213 REMARK 465 ASN E 214 REMARK 465 HIS E 215 REMARK 465 LYS E 216 REMARK 465 PRO E 217 REMARK 465 SER E 218 REMARK 465 ASN E 219 REMARK 465 THR E 220 REMARK 465 LYS E 221 REMARK 465 VAL E 222 REMARK 465 ASP E 223 REMARK 465 LYS E 224 REMARK 465 LYS E 225 REMARK 465 VAL E 226 REMARK 465 GLU E 227 REMARK 465 PRO E 228 REMARK 465 LYS E 229 REMARK 465 SER E 230 REMARK 465 CYS E 231 REMARK 465 GLN G 1 REMARK 465 SER G 2 REMARK 465 ALA G 3 REMARK 465 LEU G 111 REMARK 465 GLY G 112 REMARK 465 GLN G 113 REMARK 465 PRO G 114 REMARK 465 LYS G 115 REMARK 465 ALA G 116 REMARK 465 ALA G 117 REMARK 465 PRO G 118 REMARK 465 SER G 119 REMARK 465 VAL G 120 REMARK 465 THR G 121 REMARK 465 LEU G 122 REMARK 465 PHE G 123 REMARK 465 PRO G 124 REMARK 465 PRO G 125 REMARK 465 SER G 126 REMARK 465 SER G 127 REMARK 465 GLU G 128 REMARK 465 GLU G 129 REMARK 465 LEU G 130 REMARK 465 GLN G 131 REMARK 465 ALA G 132 REMARK 465 ASN G 133 REMARK 465 LYS G 134 REMARK 465 ALA G 135 REMARK 465 THR G 136 REMARK 465 LEU G 137 REMARK 465 VAL G 138 REMARK 465 CYS G 139 REMARK 465 LEU G 140 REMARK 465 ILE G 141 REMARK 465 SER G 142 REMARK 465 ASP G 143 REMARK 465 PHE G 144 REMARK 465 TYR G 145 REMARK 465 PRO G 146 REMARK 465 GLY G 147 REMARK 465 ALA G 148 REMARK 465 VAL G 149 REMARK 465 THR G 150 REMARK 465 VAL G 151 REMARK 465 ALA G 152 REMARK 465 TRP G 153 REMARK 465 LYS G 154 REMARK 465 ALA G 155 REMARK 465 ASP G 156 REMARK 465 SER G 157 REMARK 465 SER G 158 REMARK 465 PRO G 159 REMARK 465 VAL G 160 REMARK 465 LYS G 161 REMARK 465 ALA G 162 REMARK 465 GLY G 163 REMARK 465 VAL G 164 REMARK 465 GLU G 165 REMARK 465 THR G 166 REMARK 465 THR G 167 REMARK 465 THR G 168 REMARK 465 PRO G 169 REMARK 465 SER G 170 REMARK 465 LYS G 171 REMARK 465 GLN G 172 REMARK 465 SER G 173 REMARK 465 ASN G 174 REMARK 465 ASN G 175 REMARK 465 LYS G 176 REMARK 465 TYR G 177 REMARK 465 ALA G 178 REMARK 465 ALA G 179 REMARK 465 SER G 180 REMARK 465 SER G 181 REMARK 465 TYR G 182 REMARK 465 LEU G 183 REMARK 465 SER G 184 REMARK 465 LEU G 185 REMARK 465 THR G 186 REMARK 465 PRO G 187 REMARK 465 GLU G 188 REMARK 465 GLN G 189 REMARK 465 TRP G 190 REMARK 465 LYS G 191 REMARK 465 SER G 192 REMARK 465 HIS G 193 REMARK 465 ARG G 194 REMARK 465 SER G 195 REMARK 465 TYR G 196 REMARK 465 SER G 197 REMARK 465 CYS G 198 REMARK 465 GLN G 199 REMARK 465 VAL G 200 REMARK 465 THR G 201 REMARK 465 HIS G 202 REMARK 465 GLU G 203 REMARK 465 GLY G 204 REMARK 465 SER G 205 REMARK 465 THR G 206 REMARK 465 VAL G 207 REMARK 465 GLU G 208 REMARK 465 LYS G 209 REMARK 465 THR G 210 REMARK 465 VAL G 211 REMARK 465 ALA G 212 REMARK 465 PRO G 213 REMARK 465 THR G 214 REMARK 465 GLU G 215 REMARK 465 CYS G 216 REMARK 465 SER G 217 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 TYR A 30 CG TYR A 30 CD2 0.105 REMARK 500 TYR A 30 CG TYR A 30 CD1 0.097 REMARK 500 TYR A 30 CE1 TYR A 30 CZ 0.097 REMARK 500 TYR A 30 CZ TYR A 30 CE2 0.084 REMARK 500 GLU A 184 CD GLU A 184 OE2 -0.071 REMARK 500 ASN A 896 CB ASN A 896 CG -0.161 REMARK 500 TYR N 38 CB TYR N 38 CG -0.102 REMARK 500 TYR B 30 CG TYR B 30 CD2 0.105 REMARK 500 TYR B 30 CG TYR B 30 CD1 0.097 REMARK 500 TYR B 30 CE1 TYR B 30 CZ 0.098 REMARK 500 TYR B 30 CZ TYR B 30 CE2 0.083 REMARK 500 GLU B 184 CD GLU B 184 OE2 -0.070 REMARK 500 ASN B 896 CB ASN B 896 CG -0.161 REMARK 500 TYR F 38 CB TYR F 38 CG -0.103 REMARK 500 TYR C 30 CG TYR C 30 CD2 0.105 REMARK 500 TYR C 30 CG TYR C 30 CD1 0.097 REMARK 500 TYR C 30 CE1 TYR C 30 CZ 0.098 REMARK 500 TYR C 30 CZ TYR C 30 CE2 0.083 REMARK 500 GLU C 184 CD GLU C 184 OE2 -0.070 REMARK 500 ASN C 896 CB ASN C 896 CG -0.160 REMARK 500 TYR G 38 CB TYR G 38 CG -0.102 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 TYR A 63 CB - CG - CD2 ANGL. DEV. = -3.9 DEGREES REMARK 500 TYR A 88 CB - CG - CD2 ANGL. DEV. = -3.7 DEGREES REMARK 500 TYR A 197 CB - CG - CD2 ANGL. DEV. = -4.2 DEGREES REMARK 500 PHE A 262 CB - CG - CD2 ANGL. DEV. = -5.0 DEGREES REMARK 500 PHE A 262 CB - CG - CD1 ANGL. DEV. = 4.4 DEGREES REMARK 500 TYR A 266 CB - CG - CD2 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG A 315 NE - CZ - NH1 ANGL. DEV. = 3.2 DEGREES REMARK 500 TYR A 660 CB - CG - CD1 ANGL. DEV. = -3.6 DEGREES REMARK 500 ARG A 797 NE - CZ - NH1 ANGL. DEV. = 3.5 DEGREES REMARK 500 ARG A 797 NE - CZ - NH2 ANGL. DEV. = -4.7 DEGREES REMARK 500 PHE A 870 CB - CG - CD2 ANGL. DEV. = -4.7 DEGREES REMARK 500 ARG A 887 NE - CZ - NH2 ANGL. DEV. = -4.0 DEGREES REMARK 500 ARG A 965 NE - CZ - NH2 ANGL. DEV. = -3.2 DEGREES REMARK 500 ARG A1021 NE - CZ - NH2 ANGL. DEV. = -3.2 DEGREES REMARK 500 PRO M 14 C - N - CA ANGL. DEV. = 9.1 DEGREES REMARK 500 TYR N 38 CB - CG - CD2 ANGL. DEV. = -4.8 DEGREES REMARK 500 TYR B 63 CB - CG - CD2 ANGL. DEV. = -3.9 DEGREES REMARK 500 TYR B 88 CB - CG - CD2 ANGL. DEV. = -3.7 DEGREES REMARK 500 TYR B 197 CB - CG - CD2 ANGL. DEV. = -4.2 DEGREES REMARK 500 PHE B 262 CB - CG - CD2 ANGL. DEV. = -5.0 DEGREES REMARK 500 PHE B 262 CB - CG - CD1 ANGL. DEV. = 4.4 DEGREES REMARK 500 TYR B 266 CB - CG - CD2 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG B 315 NE - CZ - NH1 ANGL. DEV. = 3.1 DEGREES REMARK 500 TYR B 660 CB - CG - CD1 ANGL. DEV. = -3.6 DEGREES REMARK 500 ARG B 797 NE - CZ - NH1 ANGL. DEV. = 3.4 DEGREES REMARK 500 ARG B 797 NE - CZ - NH2 ANGL. DEV. = -4.7 DEGREES REMARK 500 PHE B 870 CB - CG - CD2 ANGL. DEV. = -4.7 DEGREES REMARK 500 ARG B 887 NE - CZ - NH2 ANGL. DEV. = -4.0 DEGREES REMARK 500 ARG B 965 NE - CZ - NH2 ANGL. DEV. = -3.2 DEGREES REMARK 500 ARG B1021 NE - CZ - NH2 ANGL. DEV. = -3.2 DEGREES REMARK 500 PRO D 14 C - N - CA ANGL. DEV. = 9.1 DEGREES REMARK 500 TYR F 38 CB - CG - CD2 ANGL. DEV. = -4.8 DEGREES REMARK 500 TYR C 63 CB - CG - CD2 ANGL. DEV. = -3.9 DEGREES REMARK 500 TYR C 88 CB - CG - CD2 ANGL. DEV. = -3.7 DEGREES REMARK 500 TYR C 197 CB - CG - CD2 ANGL. DEV. = -4.2 DEGREES REMARK 500 PHE C 262 CB - CG - CD2 ANGL. DEV. = -5.0 DEGREES REMARK 500 PHE C 262 CB - CG - CD1 ANGL. DEV. = 4.3 DEGREES REMARK 500 TYR C 266 CB - CG - CD2 ANGL. DEV. = -3.8 DEGREES REMARK 500 ARG C 315 NE - CZ - NH1 ANGL. DEV. = 3.1 DEGREES REMARK 500 TYR C 660 CB - CG - CD1 ANGL. DEV. = -3.6 DEGREES REMARK 500 ARG C 797 NE - CZ - NH1 ANGL. DEV. = 3.4 DEGREES REMARK 500 ARG C 797 NE - CZ - NH2 ANGL. DEV. = -4.7 DEGREES REMARK 500 PHE C 870 CB - CG - CD2 ANGL. DEV. = -4.7 DEGREES REMARK 500 ARG C 887 NE - CZ - NH2 ANGL. DEV. = -4.0 DEGREES REMARK 500 ARG C 965 NE - CZ - NH2 ANGL. DEV. = -3.2 DEGREES REMARK 500 ARG C1021 NE - CZ - NH2 ANGL. DEV. = -3.3 DEGREES REMARK 500 PRO E 14 C - N - CA ANGL. DEV. = 9.1 DEGREES REMARK 500 TYR G 38 CB - CG - CD2 ANGL. DEV. = -4.8 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLU A 93 -114.30 50.17 REMARK 500 ASP A 649 -80.49 -118.11 REMARK 500 ALA A 654 -145.33 56.36 REMARK 500 THR A 925 -9.34 72.31 REMARK 500 CYS A1025 35.19 71.13 REMARK 500 THR A1082 -53.93 -122.16 REMARK 500 PHE A1091 117.71 -166.22 REMARK 500 SER A1093 87.41 -158.97 REMARK 500 ASN M 30 -115.63 51.23 REMARK 500 TYR M 94 76.16 38.68 REMARK 500 THR N 25 -153.26 -158.17 REMARK 500 ASP N 28 -120.63 57.26 REMARK 500 ASN N 33 56.55 -90.98 REMARK 500 PHE N 99 -63.92 66.54 REMARK 500 GLU B 93 -114.30 50.17 REMARK 500 ASP B 649 -80.47 -118.13 REMARK 500 ALA B 654 -145.36 56.36 REMARK 500 THR B 925 -9.28 72.27 REMARK 500 CYS B1025 35.21 71.12 REMARK 500 THR B1082 -53.95 -122.10 REMARK 500 PHE B1091 117.73 -166.21 REMARK 500 SER B1093 87.40 -158.93 REMARK 500 ASN D 30 -115.64 51.27 REMARK 500 TYR D 94 76.18 38.62 REMARK 500 THR F 25 -153.31 -158.19 REMARK 500 ASP F 28 -120.68 57.26 REMARK 500 ASN F 33 56.55 -91.02 REMARK 500 PHE F 99 -63.94 66.56 REMARK 500 GLU C 93 -114.29 50.18 REMARK 500 ASP C 649 -80.47 -118.11 REMARK 500 ALA C 654 -145.36 56.33 REMARK 500 THR C 925 -9.34 72.31 REMARK 500 CYS C1025 35.18 71.15 REMARK 500 THR C1082 -53.90 -122.18 REMARK 500 PHE C1091 117.75 -166.22 REMARK 500 SER C1093 87.38 -158.97 REMARK 500 ASN E 30 -115.63 51.24 REMARK 500 TYR E 94 76.20 38.65 REMARK 500 THR G 25 -153.27 -158.15 REMARK 500 ASP G 28 -120.65 57.27 REMARK 500 ASN G 33 56.55 -91.01 REMARK 500 PHE G 99 -63.90 66.46 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-43407 RELATED DB: EMDB REMARK 900 STRUCTURE OF SARS-COV SPIKE IN COMPLEX WITH COV1-65 FAB (NTD-BOUND) DBREF 8VPF A 1 1190 UNP P59594 SPIKE_SARS 1 1190 DBREF 8VPF M 1 231 PDB 8VPF 8VPF 1 231 DBREF 8VPF N 1 217 PDB 8VPF 8VPF 1 217 DBREF 8VPF B 1 1190 UNP P59594 SPIKE_SARS 1 1190 DBREF 8VPF D 1 231 PDB 8VPF 8VPF 1 231 DBREF 8VPF F 1 217 PDB 8VPF 8VPF 1 217 DBREF 8VPF C 1 1190 UNP P59594 SPIKE_SARS 1 1190 DBREF 8VPF E 1 231 PDB 8VPF 8VPF 1 231 DBREF 8VPF G 1 217 PDB 8VPF 8VPF 1 217 SEQADV 8VPF ALA A 577 UNP P59594 SER 577 VARIANT SEQADV 8VPF PRO A 968 UNP P59594 LYS 968 CONFLICT SEQADV 8VPF PRO A 969 UNP P59594 VAL 969 CONFLICT SEQADV 8VPF GLY A 1191 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER A 1192 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY A 1193 UNP P59594 EXPRESSION TAG SEQADV 8VPF TYR A 1194 UNP P59594 EXPRESSION TAG SEQADV 8VPF ILE A 1195 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO A 1196 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU A 1197 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA A 1198 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO A 1199 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG A 1200 UNP P59594 EXPRESSION TAG SEQADV 8VPF ASP A 1201 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY A 1202 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN A 1203 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA A 1204 UNP P59594 EXPRESSION TAG SEQADV 8VPF TYR A 1205 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL A 1206 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG A 1207 UNP P59594 EXPRESSION TAG SEQADV 8VPF LYS A 1208 UNP P59594 EXPRESSION TAG SEQADV 8VPF ASP A 1209 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY A 1210 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU A 1211 UNP P59594 EXPRESSION TAG SEQADV 8VPF TRP A 1212 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL A 1213 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU A 1214 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU A 1215 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER A 1216 UNP P59594 EXPRESSION TAG SEQADV 8VPF THR A 1217 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE A 1218 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU A 1219 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY A 1220 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG A 1221 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER A 1222 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU A 1223 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU A 1224 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL A 1225 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU A 1226 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE A 1227 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN A 1228 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY A 1229 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO A 1230 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY A 1231 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1232 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1233 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1234 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1235 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1236 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1237 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1238 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1239 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER A 1240 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA A 1241 UNP P59594 EXPRESSION TAG SEQADV 8VPF TRP A 1242 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER A 1243 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS A 1244 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO A 1245 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN A 1246 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE A 1247 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU A 1248 UNP P59594 EXPRESSION TAG SEQADV 8VPF LYS A 1249 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA B 577 UNP P59594 SER 577 VARIANT SEQADV 8VPF PRO B 968 UNP P59594 LYS 968 CONFLICT SEQADV 8VPF PRO B 969 UNP P59594 VAL 969 CONFLICT SEQADV 8VPF GLY B 1191 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER B 1192 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY B 1193 UNP P59594 EXPRESSION TAG SEQADV 8VPF TYR B 1194 UNP P59594 EXPRESSION TAG SEQADV 8VPF ILE B 1195 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO B 1196 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU B 1197 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA B 1198 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO B 1199 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG B 1200 UNP P59594 EXPRESSION TAG SEQADV 8VPF ASP B 1201 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY B 1202 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN B 1203 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA B 1204 UNP P59594 EXPRESSION TAG SEQADV 8VPF TYR B 1205 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL B 1206 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG B 1207 UNP P59594 EXPRESSION TAG SEQADV 8VPF LYS B 1208 UNP P59594 EXPRESSION TAG SEQADV 8VPF ASP B 1209 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY B 1210 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU B 1211 UNP P59594 EXPRESSION TAG SEQADV 8VPF TRP B 1212 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL B 1213 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU B 1214 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU B 1215 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER B 1216 UNP P59594 EXPRESSION TAG SEQADV 8VPF THR B 1217 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE B 1218 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU B 1219 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY B 1220 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG B 1221 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER B 1222 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU B 1223 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU B 1224 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL B 1225 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU B 1226 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE B 1227 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN B 1228 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY B 1229 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO B 1230 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY B 1231 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1232 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1233 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1234 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1235 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1236 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1237 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1238 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1239 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER B 1240 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA B 1241 UNP P59594 EXPRESSION TAG SEQADV 8VPF TRP B 1242 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER B 1243 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS B 1244 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO B 1245 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN B 1246 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE B 1247 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU B 1248 UNP P59594 EXPRESSION TAG SEQADV 8VPF LYS B 1249 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA C 577 UNP P59594 SER 577 VARIANT SEQADV 8VPF PRO C 968 UNP P59594 LYS 968 CONFLICT SEQADV 8VPF PRO C 969 UNP P59594 VAL 969 CONFLICT SEQADV 8VPF GLY C 1191 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER C 1192 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY C 1193 UNP P59594 EXPRESSION TAG SEQADV 8VPF TYR C 1194 UNP P59594 EXPRESSION TAG SEQADV 8VPF ILE C 1195 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO C 1196 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU C 1197 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA C 1198 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO C 1199 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG C 1200 UNP P59594 EXPRESSION TAG SEQADV 8VPF ASP C 1201 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY C 1202 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN C 1203 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA C 1204 UNP P59594 EXPRESSION TAG SEQADV 8VPF TYR C 1205 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL C 1206 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG C 1207 UNP P59594 EXPRESSION TAG SEQADV 8VPF LYS C 1208 UNP P59594 EXPRESSION TAG SEQADV 8VPF ASP C 1209 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY C 1210 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU C 1211 UNP P59594 EXPRESSION TAG SEQADV 8VPF TRP C 1212 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL C 1213 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU C 1214 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU C 1215 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER C 1216 UNP P59594 EXPRESSION TAG SEQADV 8VPF THR C 1217 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE C 1218 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU C 1219 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY C 1220 UNP P59594 EXPRESSION TAG SEQADV 8VPF ARG C 1221 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER C 1222 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU C 1223 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU C 1224 UNP P59594 EXPRESSION TAG SEQADV 8VPF VAL C 1225 UNP P59594 EXPRESSION TAG SEQADV 8VPF LEU C 1226 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE C 1227 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN C 1228 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY C 1229 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO C 1230 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLY C 1231 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1232 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1233 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1234 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1235 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1236 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1237 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1238 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1239 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER C 1240 UNP P59594 EXPRESSION TAG SEQADV 8VPF ALA C 1241 UNP P59594 EXPRESSION TAG SEQADV 8VPF TRP C 1242 UNP P59594 EXPRESSION TAG SEQADV 8VPF SER C 1243 UNP P59594 EXPRESSION TAG SEQADV 8VPF HIS C 1244 UNP P59594 EXPRESSION TAG SEQADV 8VPF PRO C 1245 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLN C 1246 UNP P59594 EXPRESSION TAG SEQADV 8VPF PHE C 1247 UNP P59594 EXPRESSION TAG SEQADV 8VPF GLU C 1248 UNP P59594 EXPRESSION TAG SEQADV 8VPF LYS C 1249 UNP P59594 EXPRESSION TAG SEQRES 1 A 1249 MET PHE ILE PHE LEU LEU PHE LEU THR LEU THR SER GLY SEQRES 2 A 1249 SER ASP LEU ASP ARG CYS THR THR PHE ASP ASP VAL GLN SEQRES 3 A 1249 ALA PRO ASN TYR THR GLN HIS THR SER SER MET ARG GLY SEQRES 4 A 1249 VAL TYR TYR PRO ASP GLU ILE PHE ARG SER ASP THR LEU SEQRES 5 A 1249 TYR LEU THR GLN ASP LEU PHE LEU PRO PHE TYR SER ASN SEQRES 6 A 1249 VAL THR GLY PHE HIS THR ILE ASN HIS THR PHE GLY ASN SEQRES 7 A 1249 PRO VAL ILE PRO PHE LYS ASP GLY ILE TYR PHE ALA ALA SEQRES 8 A 1249 THR GLU LYS SER ASN VAL VAL ARG GLY TRP VAL PHE GLY SEQRES 9 A 1249 SER THR MET ASN ASN LYS SER GLN SER VAL ILE ILE ILE SEQRES 10 A 1249 ASN ASN SER THR ASN VAL VAL ILE ARG ALA CYS ASN PHE SEQRES 11 A 1249 GLU LEU CYS ASP ASN PRO PHE PHE ALA VAL SER LYS PRO SEQRES 12 A 1249 MET GLY THR GLN THR HIS THR MET ILE PHE ASP ASN ALA SEQRES 13 A 1249 PHE ASN CYS THR PHE GLU TYR ILE SER ASP ALA PHE SER SEQRES 14 A 1249 LEU ASP VAL SER GLU LYS SER GLY ASN PHE LYS HIS LEU SEQRES 15 A 1249 ARG GLU PHE VAL PHE LYS ASN LYS ASP GLY PHE LEU TYR SEQRES 16 A 1249 VAL TYR LYS GLY TYR GLN PRO ILE ASP VAL VAL ARG ASP SEQRES 17 A 1249 LEU PRO SER GLY PHE ASN THR LEU LYS PRO ILE PHE LYS SEQRES 18 A 1249 LEU PRO LEU GLY ILE ASN ILE THR ASN PHE ARG ALA ILE SEQRES 19 A 1249 LEU THR ALA PHE SER PRO ALA GLN ASP ILE TRP GLY THR SEQRES 20 A 1249 SER ALA ALA ALA TYR PHE VAL GLY TYR LEU LYS PRO THR SEQRES 21 A 1249 THR PHE MET LEU LYS TYR ASP GLU ASN GLY THR ILE THR SEQRES 22 A 1249 ASP ALA VAL ASP CYS SER GLN ASN PRO LEU ALA GLU LEU SEQRES 23 A 1249 LYS CYS SER VAL LYS SER PHE GLU ILE ASP LYS GLY ILE SEQRES 24 A 1249 TYR GLN THR SER ASN PHE ARG VAL VAL PRO SER GLY ASP SEQRES 25 A 1249 VAL VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 26 A 1249 GLY GLU VAL PHE ASN ALA THR LYS PHE PRO SER VAL TYR SEQRES 27 A 1249 ALA TRP GLU ARG LYS LYS ILE SER ASN CYS VAL ALA ASP SEQRES 28 A 1249 TYR SER VAL LEU TYR ASN SER THR PHE PHE SER THR PHE SEQRES 29 A 1249 LYS CYS TYR GLY VAL SER ALA THR LYS LEU ASN ASP LEU SEQRES 30 A 1249 CYS PHE SER ASN VAL TYR ALA ASP SER PHE VAL VAL LYS SEQRES 31 A 1249 GLY ASP ASP VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 32 A 1249 VAL ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 33 A 1249 MET GLY CYS VAL LEU ALA TRP ASN THR ARG ASN ILE ASP SEQRES 34 A 1249 ALA THR SER THR GLY ASN TYR ASN TYR LYS TYR ARG TYR SEQRES 35 A 1249 LEU ARG HIS GLY LYS LEU ARG PRO PHE GLU ARG ASP ILE SEQRES 36 A 1249 SER ASN VAL PRO PHE SER PRO ASP GLY LYS PRO CYS THR SEQRES 37 A 1249 PRO PRO ALA LEU ASN CYS TYR TRP PRO LEU ASN ASP TYR SEQRES 38 A 1249 GLY PHE TYR THR THR THR GLY ILE GLY TYR GLN PRO TYR SEQRES 39 A 1249 ARG VAL VAL VAL LEU SER PHE GLU LEU LEU ASN ALA PRO SEQRES 40 A 1249 ALA THR VAL CYS GLY PRO LYS LEU SER THR ASP LEU ILE SEQRES 41 A 1249 LYS ASN GLN CYS VAL ASN PHE ASN PHE ASN GLY LEU THR SEQRES 42 A 1249 GLY THR GLY VAL LEU THR PRO SER SER LYS ARG PHE GLN SEQRES 43 A 1249 PRO PHE GLN GLN PHE GLY ARG ASP VAL SER ASP PHE THR SEQRES 44 A 1249 ASP SER VAL ARG ASP PRO LYS THR SER GLU ILE LEU ASP SEQRES 45 A 1249 ILE SER PRO CYS ALA PHE GLY GLY VAL SER VAL ILE THR SEQRES 46 A 1249 PRO GLY THR ASN ALA SER SER GLU VAL ALA VAL LEU TYR SEQRES 47 A 1249 GLN ASP VAL ASN CYS THR ASP VAL SER THR ALA ILE HIS SEQRES 48 A 1249 ALA ASP GLN LEU THR PRO ALA TRP ARG ILE TYR SER THR SEQRES 49 A 1249 GLY ASN ASN VAL PHE GLN THR GLN ALA GLY CYS LEU ILE SEQRES 50 A 1249 GLY ALA GLU HIS VAL ASP THR SER TYR GLU CYS ASP ILE SEQRES 51 A 1249 PRO ILE GLY ALA GLY ILE CYS ALA SER TYR HIS THR VAL SEQRES 52 A 1249 SER LEU LEU ARG SER THR SER GLN LYS SER ILE VAL ALA SEQRES 53 A 1249 TYR THR MET SER LEU GLY ALA ASP SER SER ILE ALA TYR SEQRES 54 A 1249 SER ASN ASN THR ILE ALA ILE PRO THR ASN PHE SER ILE SEQRES 55 A 1249 SER ILE THR THR GLU VAL MET PRO VAL SER MET ALA LYS SEQRES 56 A 1249 THR SER VAL ASP CYS ASN MET TYR ILE CYS GLY ASP SER SEQRES 57 A 1249 THR GLU CYS ALA ASN LEU LEU LEU GLN TYR GLY SER PHE SEQRES 58 A 1249 CYS THR GLN LEU ASN ARG ALA LEU SER GLY ILE ALA ALA SEQRES 59 A 1249 GLU GLN ASP ARG ASN THR ARG GLU VAL PHE ALA GLN VAL SEQRES 60 A 1249 LYS GLN MET TYR LYS THR PRO THR LEU LYS TYR PHE GLY SEQRES 61 A 1249 GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO LEU LYS SEQRES 62 A 1249 PRO THR LYS ARG SER PHE ILE GLU ASP LEU LEU PHE ASN SEQRES 63 A 1249 LYS VAL THR LEU ALA ASP ALA GLY PHE MET LYS GLN TYR SEQRES 64 A 1249 GLY GLU CYS LEU GLY ASP ILE ASN ALA ARG ASP LEU ILE SEQRES 65 A 1249 CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO SEQRES 66 A 1249 LEU LEU THR ASP ASP MET ILE ALA ALA TYR THR ALA ALA SEQRES 67 A 1249 LEU VAL SER GLY THR ALA THR ALA GLY TRP THR PHE GLY SEQRES 68 A 1249 ALA GLY ALA ALA LEU GLN ILE PRO PHE ALA MET GLN MET SEQRES 69 A 1249 ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL SEQRES 70 A 1249 LEU TYR GLU ASN GLN LYS GLN ILE ALA ASN GLN PHE ASN SEQRES 71 A 1249 LYS ALA ILE SER GLN ILE GLN GLU SER LEU THR THR THR SEQRES 72 A 1249 SER THR ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN GLN SEQRES 73 A 1249 ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SEQRES 74 A 1249 SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE SEQRES 75 A 1249 LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE SEQRES 76 A 1249 ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR SEQRES 77 A 1249 TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG SEQRES 78 A 1249 ALA SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS SEQRES 79 A 1249 VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS SEQRES 80 A 1249 GLY TYR HIS LEU MET SER PHE PRO GLN ALA ALA PRO HIS SEQRES 81 A 1249 GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SER GLN SEQRES 82 A 1249 GLU ARG ASN PHE THR THR ALA PRO ALA ILE CYS HIS GLU SEQRES 83 A 1249 GLY LYS ALA TYR PHE PRO ARG GLU GLY VAL PHE VAL PHE SEQRES 84 A 1249 ASN GLY THR SER TRP PHE ILE THR GLN ARG ASN PHE PHE SEQRES 85 A 1249 SER PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER SEQRES 86 A 1249 GLY ASN CYS ASP VAL VAL ILE GLY ILE ILE ASN ASN THR SEQRES 87 A 1249 VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS SEQRES 88 A 1249 GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO SEQRES 89 A 1249 ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER SEQRES 90 A 1249 VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU SEQRES 91 A 1249 VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN SEQRES 92 A 1249 GLU LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO SEQRES 93 A 1249 GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP SEQRES 94 A 1249 GLY GLU TRP VAL LEU LEU SER THR PHE LEU GLY ARG SER SEQRES 95 A 1249 LEU GLU VAL LEU PHE GLN GLY PRO GLY HIS HIS HIS HIS SEQRES 96 A 1249 HIS HIS HIS HIS SER ALA TRP SER HIS PRO GLN PHE GLU SEQRES 97 A 1249 LYS SEQRES 1 M 231 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 M 231 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 M 231 GLY THR PHE ASN TYR HIS VAL VAL GLY TRP VAL ARG GLN SEQRES 4 M 231 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY SER VAL SER SEQRES 5 M 231 PRO ALA LEU GLY ARG THR ASN TYR ALA ARG LYS PHE GLN SEQRES 6 M 231 GLY ARG VAL THR ILE THR ALA ASP LYS SER SER ASN ILE SEQRES 7 M 231 ALA TYR MET GLU LEU THR SER LEU ARG PHE GLU ASP THR SEQRES 8 M 231 ALA VAL TYR TYR CYS ALA ARG LEU LEU LEU VAL GLU TYR SEQRES 9 M 231 THR THR SER SER ARG ALA GLY GLY TYR GLY MET ASP VAL SEQRES 10 M 231 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 M 231 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 M 231 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 M 231 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 M 231 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 M 231 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 M 231 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 M 231 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 M 231 VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 N 217 GLN SER ALA LEU THR GLN PRO PRO SER ALA SER GLY SER SEQRES 2 N 217 PRO GLY GLN SER VAL THR ILE SER CYS THR GLY THR TYR SEQRES 3 N 217 ASN ASP ILE GLY GLY TYR ASN PHE VAL SER TRP TYR GLN SEQRES 4 N 217 GLN HIS ALA GLY LYS VAL PRO LYS LEU MET ILE PHE GLU SEQRES 5 N 217 VAL SER LYS ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 N 217 GLY SER LYS SER GLY ASN THR ALA SER LEU THR VAL SER SEQRES 7 N 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS SER SEQRES 8 N 217 SER PHE ALA GLY SER ASN THR PHE VAL VAL PHE GLY GLY SEQRES 9 N 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 N 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 N 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 N 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 N 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 N 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 N 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 N 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 N 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 B 1249 MET PHE ILE PHE LEU LEU PHE LEU THR LEU THR SER GLY SEQRES 2 B 1249 SER ASP LEU ASP ARG CYS THR THR PHE ASP ASP VAL GLN SEQRES 3 B 1249 ALA PRO ASN TYR THR GLN HIS THR SER SER MET ARG GLY SEQRES 4 B 1249 VAL TYR TYR PRO ASP GLU ILE PHE ARG SER ASP THR LEU SEQRES 5 B 1249 TYR LEU THR GLN ASP LEU PHE LEU PRO PHE TYR SER ASN SEQRES 6 B 1249 VAL THR GLY PHE HIS THR ILE ASN HIS THR PHE GLY ASN SEQRES 7 B 1249 PRO VAL ILE PRO PHE LYS ASP GLY ILE TYR PHE ALA ALA SEQRES 8 B 1249 THR GLU LYS SER ASN VAL VAL ARG GLY TRP VAL PHE GLY SEQRES 9 B 1249 SER THR MET ASN ASN LYS SER GLN SER VAL ILE ILE ILE SEQRES 10 B 1249 ASN ASN SER THR ASN VAL VAL ILE ARG ALA CYS ASN PHE SEQRES 11 B 1249 GLU LEU CYS ASP ASN PRO PHE PHE ALA VAL SER LYS PRO SEQRES 12 B 1249 MET GLY THR GLN THR HIS THR MET ILE PHE ASP ASN ALA SEQRES 13 B 1249 PHE ASN CYS THR PHE GLU TYR ILE SER ASP ALA PHE SER SEQRES 14 B 1249 LEU ASP VAL SER GLU LYS SER GLY ASN PHE LYS HIS LEU SEQRES 15 B 1249 ARG GLU PHE VAL PHE LYS ASN LYS ASP GLY PHE LEU TYR SEQRES 16 B 1249 VAL TYR LYS GLY TYR GLN PRO ILE ASP VAL VAL ARG ASP SEQRES 17 B 1249 LEU PRO SER GLY PHE ASN THR LEU LYS PRO ILE PHE LYS SEQRES 18 B 1249 LEU PRO LEU GLY ILE ASN ILE THR ASN PHE ARG ALA ILE SEQRES 19 B 1249 LEU THR ALA PHE SER PRO ALA GLN ASP ILE TRP GLY THR SEQRES 20 B 1249 SER ALA ALA ALA TYR PHE VAL GLY TYR LEU LYS PRO THR SEQRES 21 B 1249 THR PHE MET LEU LYS TYR ASP GLU ASN GLY THR ILE THR SEQRES 22 B 1249 ASP ALA VAL ASP CYS SER GLN ASN PRO LEU ALA GLU LEU SEQRES 23 B 1249 LYS CYS SER VAL LYS SER PHE GLU ILE ASP LYS GLY ILE SEQRES 24 B 1249 TYR GLN THR SER ASN PHE ARG VAL VAL PRO SER GLY ASP SEQRES 25 B 1249 VAL VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 26 B 1249 GLY GLU VAL PHE ASN ALA THR LYS PHE PRO SER VAL TYR SEQRES 27 B 1249 ALA TRP GLU ARG LYS LYS ILE SER ASN CYS VAL ALA ASP SEQRES 28 B 1249 TYR SER VAL LEU TYR ASN SER THR PHE PHE SER THR PHE SEQRES 29 B 1249 LYS CYS TYR GLY VAL SER ALA THR LYS LEU ASN ASP LEU SEQRES 30 B 1249 CYS PHE SER ASN VAL TYR ALA ASP SER PHE VAL VAL LYS SEQRES 31 B 1249 GLY ASP ASP VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 32 B 1249 VAL ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 33 B 1249 MET GLY CYS VAL LEU ALA TRP ASN THR ARG ASN ILE ASP SEQRES 34 B 1249 ALA THR SER THR GLY ASN TYR ASN TYR LYS TYR ARG TYR SEQRES 35 B 1249 LEU ARG HIS GLY LYS LEU ARG PRO PHE GLU ARG ASP ILE SEQRES 36 B 1249 SER ASN VAL PRO PHE SER PRO ASP GLY LYS PRO CYS THR SEQRES 37 B 1249 PRO PRO ALA LEU ASN CYS TYR TRP PRO LEU ASN ASP TYR SEQRES 38 B 1249 GLY PHE TYR THR THR THR GLY ILE GLY TYR GLN PRO TYR SEQRES 39 B 1249 ARG VAL VAL VAL LEU SER PHE GLU LEU LEU ASN ALA PRO SEQRES 40 B 1249 ALA THR VAL CYS GLY PRO LYS LEU SER THR ASP LEU ILE SEQRES 41 B 1249 LYS ASN GLN CYS VAL ASN PHE ASN PHE ASN GLY LEU THR SEQRES 42 B 1249 GLY THR GLY VAL LEU THR PRO SER SER LYS ARG PHE GLN SEQRES 43 B 1249 PRO PHE GLN GLN PHE GLY ARG ASP VAL SER ASP PHE THR SEQRES 44 B 1249 ASP SER VAL ARG ASP PRO LYS THR SER GLU ILE LEU ASP SEQRES 45 B 1249 ILE SER PRO CYS ALA PHE GLY GLY VAL SER VAL ILE THR SEQRES 46 B 1249 PRO GLY THR ASN ALA SER SER GLU VAL ALA VAL LEU TYR SEQRES 47 B 1249 GLN ASP VAL ASN CYS THR ASP VAL SER THR ALA ILE HIS SEQRES 48 B 1249 ALA ASP GLN LEU THR PRO ALA TRP ARG ILE TYR SER THR SEQRES 49 B 1249 GLY ASN ASN VAL PHE GLN THR GLN ALA GLY CYS LEU ILE SEQRES 50 B 1249 GLY ALA GLU HIS VAL ASP THR SER TYR GLU CYS ASP ILE SEQRES 51 B 1249 PRO ILE GLY ALA GLY ILE CYS ALA SER TYR HIS THR VAL SEQRES 52 B 1249 SER LEU LEU ARG SER THR SER GLN LYS SER ILE VAL ALA SEQRES 53 B 1249 TYR THR MET SER LEU GLY ALA ASP SER SER ILE ALA TYR SEQRES 54 B 1249 SER ASN ASN THR ILE ALA ILE PRO THR ASN PHE SER ILE SEQRES 55 B 1249 SER ILE THR THR GLU VAL MET PRO VAL SER MET ALA LYS SEQRES 56 B 1249 THR SER VAL ASP CYS ASN MET TYR ILE CYS GLY ASP SER SEQRES 57 B 1249 THR GLU CYS ALA ASN LEU LEU LEU GLN TYR GLY SER PHE SEQRES 58 B 1249 CYS THR GLN LEU ASN ARG ALA LEU SER GLY ILE ALA ALA SEQRES 59 B 1249 GLU GLN ASP ARG ASN THR ARG GLU VAL PHE ALA GLN VAL SEQRES 60 B 1249 LYS GLN MET TYR LYS THR PRO THR LEU LYS TYR PHE GLY SEQRES 61 B 1249 GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO LEU LYS SEQRES 62 B 1249 PRO THR LYS ARG SER PHE ILE GLU ASP LEU LEU PHE ASN SEQRES 63 B 1249 LYS VAL THR LEU ALA ASP ALA GLY PHE MET LYS GLN TYR SEQRES 64 B 1249 GLY GLU CYS LEU GLY ASP ILE ASN ALA ARG ASP LEU ILE SEQRES 65 B 1249 CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO SEQRES 66 B 1249 LEU LEU THR ASP ASP MET ILE ALA ALA TYR THR ALA ALA SEQRES 67 B 1249 LEU VAL SER GLY THR ALA THR ALA GLY TRP THR PHE GLY SEQRES 68 B 1249 ALA GLY ALA ALA LEU GLN ILE PRO PHE ALA MET GLN MET SEQRES 69 B 1249 ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL SEQRES 70 B 1249 LEU TYR GLU ASN GLN LYS GLN ILE ALA ASN GLN PHE ASN SEQRES 71 B 1249 LYS ALA ILE SER GLN ILE GLN GLU SER LEU THR THR THR SEQRES 72 B 1249 SER THR ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN GLN SEQRES 73 B 1249 ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SEQRES 74 B 1249 SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE SEQRES 75 B 1249 LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE SEQRES 76 B 1249 ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR SEQRES 77 B 1249 TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG SEQRES 78 B 1249 ALA SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS SEQRES 79 B 1249 VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS SEQRES 80 B 1249 GLY TYR HIS LEU MET SER PHE PRO GLN ALA ALA PRO HIS SEQRES 81 B 1249 GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SER GLN SEQRES 82 B 1249 GLU ARG ASN PHE THR THR ALA PRO ALA ILE CYS HIS GLU SEQRES 83 B 1249 GLY LYS ALA TYR PHE PRO ARG GLU GLY VAL PHE VAL PHE SEQRES 84 B 1249 ASN GLY THR SER TRP PHE ILE THR GLN ARG ASN PHE PHE SEQRES 85 B 1249 SER PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER SEQRES 86 B 1249 GLY ASN CYS ASP VAL VAL ILE GLY ILE ILE ASN ASN THR SEQRES 87 B 1249 VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS SEQRES 88 B 1249 GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO SEQRES 89 B 1249 ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER SEQRES 90 B 1249 VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU SEQRES 91 B 1249 VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN SEQRES 92 B 1249 GLU LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO SEQRES 93 B 1249 GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP SEQRES 94 B 1249 GLY GLU TRP VAL LEU LEU SER THR PHE LEU GLY ARG SER SEQRES 95 B 1249 LEU GLU VAL LEU PHE GLN GLY PRO GLY HIS HIS HIS HIS SEQRES 96 B 1249 HIS HIS HIS HIS SER ALA TRP SER HIS PRO GLN PHE GLU SEQRES 97 B 1249 LYS SEQRES 1 D 231 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 D 231 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 D 231 GLY THR PHE ASN TYR HIS VAL VAL GLY TRP VAL ARG GLN SEQRES 4 D 231 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY SER VAL SER SEQRES 5 D 231 PRO ALA LEU GLY ARG THR ASN TYR ALA ARG LYS PHE GLN SEQRES 6 D 231 GLY ARG VAL THR ILE THR ALA ASP LYS SER SER ASN ILE SEQRES 7 D 231 ALA TYR MET GLU LEU THR SER LEU ARG PHE GLU ASP THR SEQRES 8 D 231 ALA VAL TYR TYR CYS ALA ARG LEU LEU LEU VAL GLU TYR SEQRES 9 D 231 THR THR SER SER ARG ALA GLY GLY TYR GLY MET ASP VAL SEQRES 10 D 231 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 D 231 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 D 231 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 D 231 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 D 231 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 D 231 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 D 231 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 D 231 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 D 231 VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 F 217 GLN SER ALA LEU THR GLN PRO PRO SER ALA SER GLY SER SEQRES 2 F 217 PRO GLY GLN SER VAL THR ILE SER CYS THR GLY THR TYR SEQRES 3 F 217 ASN ASP ILE GLY GLY TYR ASN PHE VAL SER TRP TYR GLN SEQRES 4 F 217 GLN HIS ALA GLY LYS VAL PRO LYS LEU MET ILE PHE GLU SEQRES 5 F 217 VAL SER LYS ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 F 217 GLY SER LYS SER GLY ASN THR ALA SER LEU THR VAL SER SEQRES 7 F 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS SER SEQRES 8 F 217 SER PHE ALA GLY SER ASN THR PHE VAL VAL PHE GLY GLY SEQRES 9 F 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 F 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 F 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 F 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 F 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 F 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 F 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 F 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 F 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 C 1249 MET PHE ILE PHE LEU LEU PHE LEU THR LEU THR SER GLY SEQRES 2 C 1249 SER ASP LEU ASP ARG CYS THR THR PHE ASP ASP VAL GLN SEQRES 3 C 1249 ALA PRO ASN TYR THR GLN HIS THR SER SER MET ARG GLY SEQRES 4 C 1249 VAL TYR TYR PRO ASP GLU ILE PHE ARG SER ASP THR LEU SEQRES 5 C 1249 TYR LEU THR GLN ASP LEU PHE LEU PRO PHE TYR SER ASN SEQRES 6 C 1249 VAL THR GLY PHE HIS THR ILE ASN HIS THR PHE GLY ASN SEQRES 7 C 1249 PRO VAL ILE PRO PHE LYS ASP GLY ILE TYR PHE ALA ALA SEQRES 8 C 1249 THR GLU LYS SER ASN VAL VAL ARG GLY TRP VAL PHE GLY SEQRES 9 C 1249 SER THR MET ASN ASN LYS SER GLN SER VAL ILE ILE ILE SEQRES 10 C 1249 ASN ASN SER THR ASN VAL VAL ILE ARG ALA CYS ASN PHE SEQRES 11 C 1249 GLU LEU CYS ASP ASN PRO PHE PHE ALA VAL SER LYS PRO SEQRES 12 C 1249 MET GLY THR GLN THR HIS THR MET ILE PHE ASP ASN ALA SEQRES 13 C 1249 PHE ASN CYS THR PHE GLU TYR ILE SER ASP ALA PHE SER SEQRES 14 C 1249 LEU ASP VAL SER GLU LYS SER GLY ASN PHE LYS HIS LEU SEQRES 15 C 1249 ARG GLU PHE VAL PHE LYS ASN LYS ASP GLY PHE LEU TYR SEQRES 16 C 1249 VAL TYR LYS GLY TYR GLN PRO ILE ASP VAL VAL ARG ASP SEQRES 17 C 1249 LEU PRO SER GLY PHE ASN THR LEU LYS PRO ILE PHE LYS SEQRES 18 C 1249 LEU PRO LEU GLY ILE ASN ILE THR ASN PHE ARG ALA ILE SEQRES 19 C 1249 LEU THR ALA PHE SER PRO ALA GLN ASP ILE TRP GLY THR SEQRES 20 C 1249 SER ALA ALA ALA TYR PHE VAL GLY TYR LEU LYS PRO THR SEQRES 21 C 1249 THR PHE MET LEU LYS TYR ASP GLU ASN GLY THR ILE THR SEQRES 22 C 1249 ASP ALA VAL ASP CYS SER GLN ASN PRO LEU ALA GLU LEU SEQRES 23 C 1249 LYS CYS SER VAL LYS SER PHE GLU ILE ASP LYS GLY ILE SEQRES 24 C 1249 TYR GLN THR SER ASN PHE ARG VAL VAL PRO SER GLY ASP SEQRES 25 C 1249 VAL VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 26 C 1249 GLY GLU VAL PHE ASN ALA THR LYS PHE PRO SER VAL TYR SEQRES 27 C 1249 ALA TRP GLU ARG LYS LYS ILE SER ASN CYS VAL ALA ASP SEQRES 28 C 1249 TYR SER VAL LEU TYR ASN SER THR PHE PHE SER THR PHE SEQRES 29 C 1249 LYS CYS TYR GLY VAL SER ALA THR LYS LEU ASN ASP LEU SEQRES 30 C 1249 CYS PHE SER ASN VAL TYR ALA ASP SER PHE VAL VAL LYS SEQRES 31 C 1249 GLY ASP ASP VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 32 C 1249 VAL ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 33 C 1249 MET GLY CYS VAL LEU ALA TRP ASN THR ARG ASN ILE ASP SEQRES 34 C 1249 ALA THR SER THR GLY ASN TYR ASN TYR LYS TYR ARG TYR SEQRES 35 C 1249 LEU ARG HIS GLY LYS LEU ARG PRO PHE GLU ARG ASP ILE SEQRES 36 C 1249 SER ASN VAL PRO PHE SER PRO ASP GLY LYS PRO CYS THR SEQRES 37 C 1249 PRO PRO ALA LEU ASN CYS TYR TRP PRO LEU ASN ASP TYR SEQRES 38 C 1249 GLY PHE TYR THR THR THR GLY ILE GLY TYR GLN PRO TYR SEQRES 39 C 1249 ARG VAL VAL VAL LEU SER PHE GLU LEU LEU ASN ALA PRO SEQRES 40 C 1249 ALA THR VAL CYS GLY PRO LYS LEU SER THR ASP LEU ILE SEQRES 41 C 1249 LYS ASN GLN CYS VAL ASN PHE ASN PHE ASN GLY LEU THR SEQRES 42 C 1249 GLY THR GLY VAL LEU THR PRO SER SER LYS ARG PHE GLN SEQRES 43 C 1249 PRO PHE GLN GLN PHE GLY ARG ASP VAL SER ASP PHE THR SEQRES 44 C 1249 ASP SER VAL ARG ASP PRO LYS THR SER GLU ILE LEU ASP SEQRES 45 C 1249 ILE SER PRO CYS ALA PHE GLY GLY VAL SER VAL ILE THR SEQRES 46 C 1249 PRO GLY THR ASN ALA SER SER GLU VAL ALA VAL LEU TYR SEQRES 47 C 1249 GLN ASP VAL ASN CYS THR ASP VAL SER THR ALA ILE HIS SEQRES 48 C 1249 ALA ASP GLN LEU THR PRO ALA TRP ARG ILE TYR SER THR SEQRES 49 C 1249 GLY ASN ASN VAL PHE GLN THR GLN ALA GLY CYS LEU ILE SEQRES 50 C 1249 GLY ALA GLU HIS VAL ASP THR SER TYR GLU CYS ASP ILE SEQRES 51 C 1249 PRO ILE GLY ALA GLY ILE CYS ALA SER TYR HIS THR VAL SEQRES 52 C 1249 SER LEU LEU ARG SER THR SER GLN LYS SER ILE VAL ALA SEQRES 53 C 1249 TYR THR MET SER LEU GLY ALA ASP SER SER ILE ALA TYR SEQRES 54 C 1249 SER ASN ASN THR ILE ALA ILE PRO THR ASN PHE SER ILE SEQRES 55 C 1249 SER ILE THR THR GLU VAL MET PRO VAL SER MET ALA LYS SEQRES 56 C 1249 THR SER VAL ASP CYS ASN MET TYR ILE CYS GLY ASP SER SEQRES 57 C 1249 THR GLU CYS ALA ASN LEU LEU LEU GLN TYR GLY SER PHE SEQRES 58 C 1249 CYS THR GLN LEU ASN ARG ALA LEU SER GLY ILE ALA ALA SEQRES 59 C 1249 GLU GLN ASP ARG ASN THR ARG GLU VAL PHE ALA GLN VAL SEQRES 60 C 1249 LYS GLN MET TYR LYS THR PRO THR LEU LYS TYR PHE GLY SEQRES 61 C 1249 GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO LEU LYS SEQRES 62 C 1249 PRO THR LYS ARG SER PHE ILE GLU ASP LEU LEU PHE ASN SEQRES 63 C 1249 LYS VAL THR LEU ALA ASP ALA GLY PHE MET LYS GLN TYR SEQRES 64 C 1249 GLY GLU CYS LEU GLY ASP ILE ASN ALA ARG ASP LEU ILE SEQRES 65 C 1249 CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO SEQRES 66 C 1249 LEU LEU THR ASP ASP MET ILE ALA ALA TYR THR ALA ALA SEQRES 67 C 1249 LEU VAL SER GLY THR ALA THR ALA GLY TRP THR PHE GLY SEQRES 68 C 1249 ALA GLY ALA ALA LEU GLN ILE PRO PHE ALA MET GLN MET SEQRES 69 C 1249 ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL SEQRES 70 C 1249 LEU TYR GLU ASN GLN LYS GLN ILE ALA ASN GLN PHE ASN SEQRES 71 C 1249 LYS ALA ILE SER GLN ILE GLN GLU SER LEU THR THR THR SEQRES 72 C 1249 SER THR ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN GLN SEQRES 73 C 1249 ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SEQRES 74 C 1249 SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE SEQRES 75 C 1249 LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE SEQRES 76 C 1249 ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR SEQRES 77 C 1249 TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG SEQRES 78 C 1249 ALA SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS SEQRES 79 C 1249 VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS SEQRES 80 C 1249 GLY TYR HIS LEU MET SER PHE PRO GLN ALA ALA PRO HIS SEQRES 81 C 1249 GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SER GLN SEQRES 82 C 1249 GLU ARG ASN PHE THR THR ALA PRO ALA ILE CYS HIS GLU SEQRES 83 C 1249 GLY LYS ALA TYR PHE PRO ARG GLU GLY VAL PHE VAL PHE SEQRES 84 C 1249 ASN GLY THR SER TRP PHE ILE THR GLN ARG ASN PHE PHE SEQRES 85 C 1249 SER PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER SEQRES 86 C 1249 GLY ASN CYS ASP VAL VAL ILE GLY ILE ILE ASN ASN THR SEQRES 87 C 1249 VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS SEQRES 88 C 1249 GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO SEQRES 89 C 1249 ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER SEQRES 90 C 1249 VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU SEQRES 91 C 1249 VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN SEQRES 92 C 1249 GLU LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO SEQRES 93 C 1249 GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP SEQRES 94 C 1249 GLY GLU TRP VAL LEU LEU SER THR PHE LEU GLY ARG SER SEQRES 95 C 1249 LEU GLU VAL LEU PHE GLN GLY PRO GLY HIS HIS HIS HIS SEQRES 96 C 1249 HIS HIS HIS HIS SER ALA TRP SER HIS PRO GLN PHE GLU SEQRES 97 C 1249 LYS SEQRES 1 E 231 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 E 231 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 E 231 GLY THR PHE ASN TYR HIS VAL VAL GLY TRP VAL ARG GLN SEQRES 4 E 231 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY SER VAL SER SEQRES 5 E 231 PRO ALA LEU GLY ARG THR ASN TYR ALA ARG LYS PHE GLN SEQRES 6 E 231 GLY ARG VAL THR ILE THR ALA ASP LYS SER SER ASN ILE SEQRES 7 E 231 ALA TYR MET GLU LEU THR SER LEU ARG PHE GLU ASP THR SEQRES 8 E 231 ALA VAL TYR TYR CYS ALA ARG LEU LEU LEU VAL GLU TYR SEQRES 9 E 231 THR THR SER SER ARG ALA GLY GLY TYR GLY MET ASP VAL SEQRES 10 E 231 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 E 231 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 E 231 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 E 231 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 E 231 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 E 231 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 E 231 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 E 231 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 E 231 VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 G 217 GLN SER ALA LEU THR GLN PRO PRO SER ALA SER GLY SER SEQRES 2 G 217 PRO GLY GLN SER VAL THR ILE SER CYS THR GLY THR TYR SEQRES 3 G 217 ASN ASP ILE GLY GLY TYR ASN PHE VAL SER TRP TYR GLN SEQRES 4 G 217 GLN HIS ALA GLY LYS VAL PRO LYS LEU MET ILE PHE GLU SEQRES 5 G 217 VAL SER LYS ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 G 217 GLY SER LYS SER GLY ASN THR ALA SER LEU THR VAL SER SEQRES 7 G 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS SER SEQRES 8 G 217 SER PHE ALA GLY SER ASN THR PHE VAL VAL PHE GLY GLY SEQRES 9 G 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 G 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 G 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 G 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 G 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 G 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 G 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 G 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 G 217 LYS THR VAL ALA PRO THR GLU CYS SER HET NAG H 1 14 HET NAG H 2 14 HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET NAG J 2 14 HET BMA J 3 11 HET NAG K 1 14 HET NAG K 2 14 HET NAG L 1 14 HET NAG L 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG U 1 14 HET NAG U 2 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 39(C8 H15 N O6) FORMUL 12 BMA 3(C6 H12 O6) HELIX 1 AA1 ASN A 281 VAL A 290 1 10 HELIX 2 AA2 ASN A 602 ALA A 612 1 11 HELIX 3 AA3 ASP A 719 CYS A 725 1 7 HELIX 4 AA4 SER A 728 LEU A 735 1 8 HELIX 5 AA5 LEU A 736 GLY A 739 5 4 HELIX 6 AA6 SER A 740 ALA A 765 1 26 HELIX 7 AA7 SER A 798 PHE A 805 1 8 HELIX 8 AA8 THR A 848 ALA A 866 1 19 HELIX 9 AA9 GLY A 867 ALA A 872 5 6 HELIX 10 AB1 PRO A 879 ASN A 889 1 11 HELIX 11 AB2 THR A 894 ASN A 901 1 8 HELIX 12 AB3 ASN A 901 THR A 923 1 23 HELIX 13 AB4 LEU A 927 GLN A 947 1 21 HELIX 14 AB5 LEU A 948 SER A 950 5 3 HELIX 15 AB6 VAL A 958 LEU A 966 1 9 HELIX 16 AB7 ASP A 967 VAL A 1015 1 49 HELIX 17 AB8 ARG M 62 GLN M 65 5 4 HELIX 18 AB9 ARG M 87 THR M 91 5 5 HELIX 19 AC1 GLN N 81 GLU N 85 5 5 HELIX 20 AC2 ASN B 281 VAL B 290 1 10 HELIX 21 AC3 ASN B 602 ALA B 612 1 11 HELIX 22 AC4 ASP B 719 CYS B 725 1 7 HELIX 23 AC5 SER B 728 LEU B 735 1 8 HELIX 24 AC6 LEU B 736 GLY B 739 5 4 HELIX 25 AC7 SER B 740 ALA B 765 1 26 HELIX 26 AC8 SER B 798 PHE B 805 1 8 HELIX 27 AC9 THR B 848 ALA B 866 1 19 HELIX 28 AD1 GLY B 867 ALA B 872 5 6 HELIX 29 AD2 PRO B 879 ASN B 889 1 11 HELIX 30 AD3 THR B 894 ASN B 901 1 8 HELIX 31 AD4 ASN B 901 THR B 923 1 23 HELIX 32 AD5 LEU B 927 GLN B 947 1 21 HELIX 33 AD6 LEU B 948 SER B 950 5 3 HELIX 34 AD7 VAL B 958 LEU B 966 1 9 HELIX 35 AD8 ASP B 967 VAL B 1015 1 49 HELIX 36 AD9 ARG D 62 GLN D 65 5 4 HELIX 37 AE1 ARG D 87 THR D 91 5 5 HELIX 38 AE2 GLN F 81 GLU F 85 5 5 HELIX 39 AE3 ASN C 281 VAL C 290 1 10 HELIX 40 AE4 ASN C 602 ALA C 612 1 11 HELIX 41 AE5 ASP C 719 CYS C 725 1 7 HELIX 42 AE6 SER C 728 LEU C 735 1 8 HELIX 43 AE7 LEU C 736 GLY C 739 5 4 HELIX 44 AE8 SER C 740 ALA C 765 1 26 HELIX 45 AE9 SER C 798 PHE C 805 1 8 HELIX 46 AF1 THR C 848 ALA C 866 1 19 HELIX 47 AF2 GLY C 867 ALA C 872 5 6 HELIX 48 AF3 PRO C 879 ASN C 889 1 11 HELIX 49 AF4 THR C 894 ASN C 901 1 8 HELIX 50 AF5 ASN C 901 THR C 923 1 23 HELIX 51 AF6 LEU C 927 GLN C 947 1 21 HELIX 52 AF7 LEU C 948 SER C 950 5 3 HELIX 53 AF8 VAL C 958 LEU C 966 1 9 HELIX 54 AF9 ASP C 967 VAL C 1015 1 49 HELIX 55 AG1 ARG E 62 GLN E 65 5 4 HELIX 56 AG2 ARG E 87 THR E 91 5 5 HELIX 57 AG3 GLN G 81 GLU G 85 5 5 SHEET 1 AA1 7 THR A 31 THR A 34 0 SHEET 2 AA1 7 ASN A 65 PHE A 69 -1 O VAL A 66 N HIS A 33 SHEET 3 AA1 7 TYR A 252 TYR A 256 -1 O TYR A 252 N PHE A 69 SHEET 4 AA1 7 ILE A 87 ALA A 91 -1 N ALA A 90 O PHE A 253 SHEET 5 AA1 7 ARG A 183 LYS A 190 -1 O PHE A 185 N PHE A 89 SHEET 6 AA1 7 PHE A 193 TYR A 200 -1 O TYR A 195 N LYS A 188 SHEET 7 AA1 7 LYS A 217 LEU A 222 -1 O ILE A 219 N VAL A 196 SHEET 1 AA2 7 ILE A 46 PHE A 47 0 SHEET 2 AA2 7 PHE C 551 ARG C 553 1 O PHE C 551 N PHE A 47 SHEET 3 AA2 7 THR C 559 ARG C 563 -1 O SER C 561 N GLY C 552 SHEET 4 AA2 7 ILE C 570 PRO C 575 -1 O ILE C 573 N ASP C 560 SHEET 5 AA2 7 LEU C 532 PRO C 540 -1 N VAL C 537 O SER C 574 SHEET 6 AA2 7 CYS C 524 PHE C 529 -1 N PHE C 529 O LEU C 532 SHEET 7 AA2 7 ASP C 312 VAL C 314 1 N VAL C 313 O ASN C 528 SHEET 1 AA3 3 THR A 51 PHE A 59 0 SHEET 2 AA3 3 LYS A 258 TYR A 266 -1 O LEU A 264 N TYR A 53 SHEET 3 AA3 3 ILE A 272 ASP A 277 -1 O THR A 273 N LYS A 265 SHEET 1 AA4 2 VAL A 98 GLY A 104 0 SHEET 2 AA4 2 ASN A 230 LEU A 235 -1 O ASN A 230 N GLY A 104 SHEET 1 AA5 6 GLY A 212 ASN A 214 0 SHEET 2 AA5 6 SER M 108 ALA M 110 -1 O ARG M 109 N PHE A 213 SHEET 3 AA5 6 TYR M 95 THR M 105 -1 N VAL M 102 O ALA M 110 SHEET 4 AA5 6 HIS M 32 VAL M 37 -1 N VAL M 33 O LEU M 99 SHEET 5 AA5 6 TRP M 47 VAL M 51 -1 O VAL M 51 N VAL M 34 SHEET 6 AA5 6 THR M 58 TYR M 60 -1 O ASN M 59 N SER M 50 SHEET 1 AA6 4 GLY A 212 ASN A 214 0 SHEET 2 AA6 4 SER M 108 ALA M 110 -1 O ARG M 109 N PHE A 213 SHEET 3 AA6 4 TYR M 95 THR M 105 -1 N VAL M 102 O ALA M 110 SHEET 4 AA6 4 MET M 115 TRP M 118 -1 O VAL M 117 N ARG M 98 SHEET 1 AA7 5 GLY A 298 ARG A 306 0 SHEET 2 AA7 5 PHE A 578 THR A 585 -1 O GLY A 579 N PHE A 305 SHEET 3 AA7 5 ALA A 595 GLN A 599 -1 O ALA A 595 N ILE A 584 SHEET 4 AA7 5 GLY A 634 ILE A 637 -1 O ILE A 637 N VAL A 596 SHEET 5 AA7 5 VAL A 628 THR A 631 -1 N PHE A 629 O LEU A 636 SHEET 1 AA8 7 ASP A 312 VAL A 314 0 SHEET 2 AA8 7 CYS A 524 PHE A 529 1 O ASN A 528 N VAL A 313 SHEET 3 AA8 7 LEU A 532 PRO A 540 -1 O LEU A 532 N PHE A 529 SHEET 4 AA8 7 ILE A 570 PRO A 575 -1 O SER A 574 N VAL A 537 SHEET 5 AA8 7 THR A 559 ARG A 563 -1 N ASP A 560 O ILE A 573 SHEET 6 AA8 7 PHE A 551 ARG A 553 -1 N GLY A 552 O SER A 561 SHEET 7 AA8 7 ILE B 46 PHE B 47 1 O PHE B 47 N PHE A 551 SHEET 1 AA9 4 GLU A 640 HIS A 641 0 SHEET 2 AA9 4 SER A 673 THR A 678 1 O ALA A 676 N GLU A 640 SHEET 3 AA9 4 ILE A 656 HIS A 661 -1 N CYS A 657 O TYR A 677 SHEET 4 AA9 4 ILE A 650 GLY A 653 -1 N ILE A 650 O ALA A 658 SHEET 1 AB1 2 ALA A 683 SER A 685 0 SHEET 2 AB1 2 GLN B 769 TYR B 771 1 O MET B 770 N ALA A 683 SHEET 1 AB2 3 THR A 693 MET A 709 0 SHEET 2 AB2 3 GLY A1041 ALA A1060 -1 O HIS A1046 N THR A 705 SHEET 3 AB2 3 TYR A1029 ALA A1038 -1 N GLN A1036 O VAL A1043 SHEET 1 AB3 5 THR A 693 MET A 709 0 SHEET 2 AB3 5 GLY A1041 ALA A1060 -1 O HIS A1046 N THR A 705 SHEET 3 AB3 5 VAL A1076 PHE A1079 -1 O PHE A1079 N THR A1058 SHEET 4 AB3 5 TRP A1084 GLN A1088 -1 O PHE A1085 N VAL A1078 SHEET 5 AB3 5 PHE A1091 ILE A1096 -1 O GLN A1095 N ILE A1086 SHEET 1 AB4 2 THR A 716 VAL A 718 0 SHEET 2 AB4 2 LEU A 840 VAL A 842 -1 O THR A 841 N SER A 717 SHEET 1 AB5 2 GLN A 769 TYR A 771 0 SHEET 2 AB5 2 ALA C 683 SER C 685 1 O ALA C 683 N MET A 770 SHEET 1 AB6 2 TYR A 778 PHE A 779 0 SHEET 2 AB6 2 PHE A 782 ASN A 783 -1 O PHE A 782 N PHE A 779 SHEET 1 AB7 3 ILE A1063 HIS A1065 0 SHEET 2 AB7 3 LYS A1068 PRO A1072 -1 O TYR A1070 N ILE A1063 SHEET 3 AB7 3 THR A1102 ASN A1107 -1 O PHE A1103 N PHE A1071 SHEET 1 AB8 4 GLN M 3 GLN M 6 0 SHEET 2 AB8 4 SER M 16 SER M 25 -1 O LYS M 23 N VAL M 5 SHEET 3 AB8 4 ILE M 78 LEU M 86 -1 O LEU M 86 N SER M 16 SHEET 4 AB8 4 VAL M 68 ASP M 73 -1 N THR M 69 O GLU M 82 SHEET 1 AB9 2 GLU M 10 LYS M 12 0 SHEET 2 AB9 2 VAL M 124 VAL M 126 1 O THR M 125 N LYS M 12 SHEET 1 AC1 5 SER N 9 SER N 11 0 SHEET 2 AC1 5 THR N 106 THR N 109 1 O THR N 109 N ALA N 10 SHEET 3 AC1 5 ASP N 87 GLY N 95 -1 N TYR N 88 O THR N 106 SHEET 4 AC1 5 VAL N 35 GLN N 40 -1 N TYR N 38 O TYR N 89 SHEET 5 AC1 5 LYS N 47 ILE N 50 -1 O MET N 49 N TRP N 37 SHEET 1 AC2 4 SER N 9 SER N 11 0 SHEET 2 AC2 4 THR N 106 THR N 109 1 O THR N 109 N ALA N 10 SHEET 3 AC2 4 ASP N 87 GLY N 95 -1 N TYR N 88 O THR N 106 SHEET 4 AC2 4 PHE N 99 PHE N 102 -1 O PHE N 99 N GLY N 95 SHEET 1 AC3 3 VAL N 18 THR N 23 0 SHEET 2 AC3 3 THR N 72 VAL N 77 -1 O ALA N 73 N CYS N 22 SHEET 3 AC3 3 PHE N 64 SER N 69 -1 N SER N 67 O SER N 74 SHEET 1 AC4 7 THR B 31 THR B 34 0 SHEET 2 AC4 7 ASN B 65 PHE B 69 -1 O VAL B 66 N HIS B 33 SHEET 3 AC4 7 TYR B 252 TYR B 256 -1 O TYR B 252 N PHE B 69 SHEET 4 AC4 7 ILE B 87 ALA B 91 -1 N ALA B 90 O PHE B 253 SHEET 5 AC4 7 ARG B 183 LYS B 190 -1 O PHE B 185 N PHE B 89 SHEET 6 AC4 7 PHE B 193 TYR B 200 -1 O TYR B 195 N LYS B 188 SHEET 7 AC4 7 LYS B 217 LEU B 222 -1 O ILE B 219 N VAL B 196 SHEET 1 AC5 3 THR B 51 PHE B 59 0 SHEET 2 AC5 3 LYS B 258 TYR B 266 -1 O LEU B 264 N TYR B 53 SHEET 3 AC5 3 ILE B 272 ASP B 277 -1 O THR B 273 N LYS B 265 SHEET 1 AC6 2 VAL B 98 GLY B 104 0 SHEET 2 AC6 2 ASN B 230 LEU B 235 -1 O ASN B 230 N GLY B 104 SHEET 1 AC7 6 GLY B 212 ASN B 214 0 SHEET 2 AC7 6 SER D 108 ALA D 110 -1 O ARG D 109 N PHE B 213 SHEET 3 AC7 6 TYR D 95 THR D 105 -1 N VAL D 102 O ALA D 110 SHEET 4 AC7 6 HIS D 32 VAL D 37 -1 N VAL D 33 O LEU D 99 SHEET 5 AC7 6 TRP D 47 VAL D 51 -1 O VAL D 51 N VAL D 34 SHEET 6 AC7 6 THR D 58 TYR D 60 -1 O ASN D 59 N SER D 50 SHEET 1 AC8 4 GLY B 212 ASN B 214 0 SHEET 2 AC8 4 SER D 108 ALA D 110 -1 O ARG D 109 N PHE B 213 SHEET 3 AC8 4 TYR D 95 THR D 105 -1 N VAL D 102 O ALA D 110 SHEET 4 AC8 4 MET D 115 TRP D 118 -1 O VAL D 117 N ARG D 98 SHEET 1 AC9 5 GLY B 298 ARG B 306 0 SHEET 2 AC9 5 PHE B 578 THR B 585 -1 O GLY B 579 N PHE B 305 SHEET 3 AC9 5 ALA B 595 GLN B 599 -1 O ALA B 595 N ILE B 584 SHEET 4 AC9 5 GLY B 634 ILE B 637 -1 O ILE B 637 N VAL B 596 SHEET 5 AC9 5 VAL B 628 THR B 631 -1 N PHE B 629 O LEU B 636 SHEET 1 AD1 7 ASP B 312 VAL B 314 0 SHEET 2 AD1 7 CYS B 524 PHE B 529 1 O ASN B 528 N VAL B 313 SHEET 3 AD1 7 LEU B 532 PRO B 540 -1 O LEU B 532 N PHE B 529 SHEET 4 AD1 7 ILE B 570 PRO B 575 -1 O SER B 574 N VAL B 537 SHEET 5 AD1 7 THR B 559 ARG B 563 -1 N ASP B 560 O ILE B 573 SHEET 6 AD1 7 PHE B 551 ARG B 553 -1 N GLY B 552 O SER B 561 SHEET 7 AD1 7 ILE C 46 PHE C 47 1 O PHE C 47 N PHE B 551 SHEET 1 AD2 4 GLU B 640 HIS B 641 0 SHEET 2 AD2 4 SER B 673 THR B 678 1 O ALA B 676 N GLU B 640 SHEET 3 AD2 4 ILE B 656 HIS B 661 -1 N CYS B 657 O TYR B 677 SHEET 4 AD2 4 ILE B 650 GLY B 653 -1 N ILE B 650 O ALA B 658 SHEET 1 AD3 2 ALA B 683 SER B 685 0 SHEET 2 AD3 2 GLN C 769 TYR C 771 1 O MET C 770 N ALA B 683 SHEET 1 AD4 3 THR B 693 MET B 709 0 SHEET 2 AD4 3 GLY B1041 ALA B1060 -1 O HIS B1046 N THR B 705 SHEET 3 AD4 3 TYR B1029 ALA B1038 -1 N GLN B1036 O VAL B1043 SHEET 1 AD5 5 THR B 693 MET B 709 0 SHEET 2 AD5 5 GLY B1041 ALA B1060 -1 O HIS B1046 N THR B 705 SHEET 3 AD5 5 VAL B1076 PHE B1079 -1 O PHE B1079 N THR B1058 SHEET 4 AD5 5 TRP B1084 GLN B1088 -1 O PHE B1085 N VAL B1078 SHEET 5 AD5 5 PHE B1091 ILE B1096 -1 O GLN B1095 N ILE B1086 SHEET 1 AD6 2 THR B 716 VAL B 718 0 SHEET 2 AD6 2 LEU B 840 VAL B 842 -1 O THR B 841 N SER B 717 SHEET 1 AD7 2 TYR B 778 PHE B 779 0 SHEET 2 AD7 2 PHE B 782 ASN B 783 -1 O PHE B 782 N PHE B 779 SHEET 1 AD8 3 ILE B1063 HIS B1065 0 SHEET 2 AD8 3 LYS B1068 PRO B1072 -1 O TYR B1070 N ILE B1063 SHEET 3 AD8 3 THR B1102 ASN B1107 -1 O PHE B1103 N PHE B1071 SHEET 1 AD9 4 GLN D 3 GLN D 6 0 SHEET 2 AD9 4 SER D 16 SER D 25 -1 O LYS D 23 N VAL D 5 SHEET 3 AD9 4 ILE D 78 LEU D 86 -1 O LEU D 86 N SER D 16 SHEET 4 AD9 4 VAL D 68 ASP D 73 -1 N THR D 69 O GLU D 82 SHEET 1 AE1 2 GLU D 10 LYS D 12 0 SHEET 2 AE1 2 VAL D 124 VAL D 126 1 O THR D 125 N LYS D 12 SHEET 1 AE2 5 SER F 9 SER F 11 0 SHEET 2 AE2 5 THR F 106 THR F 109 1 O THR F 109 N ALA F 10 SHEET 3 AE2 5 ASP F 87 GLY F 95 -1 N TYR F 88 O THR F 106 SHEET 4 AE2 5 VAL F 35 GLN F 40 -1 N TYR F 38 O TYR F 89 SHEET 5 AE2 5 LYS F 47 ILE F 50 -1 O MET F 49 N TRP F 37 SHEET 1 AE3 4 SER F 9 SER F 11 0 SHEET 2 AE3 4 THR F 106 THR F 109 1 O THR F 109 N ALA F 10 SHEET 3 AE3 4 ASP F 87 GLY F 95 -1 N TYR F 88 O THR F 106 SHEET 4 AE3 4 PHE F 99 PHE F 102 -1 O PHE F 99 N GLY F 95 SHEET 1 AE4 3 VAL F 18 THR F 23 0 SHEET 2 AE4 3 THR F 72 VAL F 77 -1 O ALA F 73 N CYS F 22 SHEET 3 AE4 3 PHE F 64 SER F 69 -1 N SER F 67 O SER F 74 SHEET 1 AE5 7 THR C 31 THR C 34 0 SHEET 2 AE5 7 ASN C 65 PHE C 69 -1 O VAL C 66 N HIS C 33 SHEET 3 AE5 7 TYR C 252 TYR C 256 -1 O TYR C 252 N PHE C 69 SHEET 4 AE5 7 ILE C 87 ALA C 91 -1 N ALA C 90 O PHE C 253 SHEET 5 AE5 7 ARG C 183 LYS C 190 -1 O PHE C 185 N PHE C 89 SHEET 6 AE5 7 PHE C 193 TYR C 200 -1 O TYR C 195 N LYS C 188 SHEET 7 AE5 7 LYS C 217 LEU C 222 -1 O ILE C 219 N VAL C 196 SHEET 1 AE6 3 THR C 51 PHE C 59 0 SHEET 2 AE6 3 LYS C 258 TYR C 266 -1 O LEU C 264 N TYR C 53 SHEET 3 AE6 3 ILE C 272 ASP C 277 -1 O THR C 273 N LYS C 265 SHEET 1 AE7 2 VAL C 98 GLY C 104 0 SHEET 2 AE7 2 ASN C 230 LEU C 235 -1 O ASN C 230 N GLY C 104 SHEET 1 AE8 6 GLY C 212 ASN C 214 0 SHEET 2 AE8 6 SER E 108 ALA E 110 -1 O ARG E 109 N PHE C 213 SHEET 3 AE8 6 TYR E 95 THR E 105 -1 N VAL E 102 O ALA E 110 SHEET 4 AE8 6 HIS E 32 VAL E 37 -1 N VAL E 33 O LEU E 99 SHEET 5 AE8 6 TRP E 47 VAL E 51 -1 O VAL E 51 N VAL E 34 SHEET 6 AE8 6 THR E 58 TYR E 60 -1 O ASN E 59 N SER E 50 SHEET 1 AE9 4 GLY C 212 ASN C 214 0 SHEET 2 AE9 4 SER E 108 ALA E 110 -1 O ARG E 109 N PHE C 213 SHEET 3 AE9 4 TYR E 95 THR E 105 -1 N VAL E 102 O ALA E 110 SHEET 4 AE9 4 MET E 115 TRP E 118 -1 O VAL E 117 N ARG E 98 SHEET 1 AF1 5 GLY C 298 ARG C 306 0 SHEET 2 AF1 5 PHE C 578 THR C 585 -1 O GLY C 579 N PHE C 305 SHEET 3 AF1 5 ALA C 595 GLN C 599 -1 O ALA C 595 N ILE C 584 SHEET 4 AF1 5 GLY C 634 ILE C 637 -1 O ILE C 637 N VAL C 596 SHEET 5 AF1 5 VAL C 628 THR C 631 -1 N PHE C 629 O LEU C 636 SHEET 1 AF2 4 GLU C 640 HIS C 641 0 SHEET 2 AF2 4 SER C 673 THR C 678 1 O ALA C 676 N GLU C 640 SHEET 3 AF2 4 ILE C 656 HIS C 661 -1 N CYS C 657 O TYR C 677 SHEET 4 AF2 4 ILE C 650 GLY C 653 -1 N ILE C 650 O ALA C 658 SHEET 1 AF3 3 THR C 693 MET C 709 0 SHEET 2 AF3 3 GLY C1041 ALA C1060 -1 O HIS C1046 N THR C 705 SHEET 3 AF3 3 TYR C1029 ALA C1038 -1 N GLN C1036 O VAL C1043 SHEET 1 AF4 5 THR C 693 MET C 709 0 SHEET 2 AF4 5 GLY C1041 ALA C1060 -1 O HIS C1046 N THR C 705 SHEET 3 AF4 5 VAL C1076 PHE C1079 -1 O PHE C1079 N THR C1058 SHEET 4 AF4 5 TRP C1084 GLN C1088 -1 O PHE C1085 N VAL C1078 SHEET 5 AF4 5 PHE C1091 ILE C1096 -1 O GLN C1095 N ILE C1086 SHEET 1 AF5 2 THR C 716 VAL C 718 0 SHEET 2 AF5 2 LEU C 840 VAL C 842 -1 O THR C 841 N SER C 717 SHEET 1 AF6 2 TYR C 778 PHE C 779 0 SHEET 2 AF6 2 PHE C 782 ASN C 783 -1 O PHE C 782 N PHE C 779 SHEET 1 AF7 3 ILE C1063 HIS C1065 0 SHEET 2 AF7 3 LYS C1068 PRO C1072 -1 O TYR C1070 N ILE C1063 SHEET 3 AF7 3 THR C1102 ASN C1107 -1 O PHE C1103 N PHE C1071 SHEET 1 AF8 4 GLN E 3 GLN E 6 0 SHEET 2 AF8 4 SER E 16 SER E 25 -1 O LYS E 23 N VAL E 5 SHEET 3 AF8 4 ILE E 78 LEU E 86 -1 O LEU E 86 N SER E 16 SHEET 4 AF8 4 VAL E 68 ASP E 73 -1 N THR E 69 O GLU E 82 SHEET 1 AF9 2 GLU E 10 LYS E 12 0 SHEET 2 AF9 2 VAL E 124 VAL E 126 1 O THR E 125 N LYS E 12 SHEET 1 AG1 5 SER G 9 SER G 11 0 SHEET 2 AG1 5 THR G 106 THR G 109 1 O THR G 109 N ALA G 10 SHEET 3 AG1 5 ASP G 87 GLY G 95 -1 N TYR G 88 O THR G 106 SHEET 4 AG1 5 VAL G 35 GLN G 40 -1 N TYR G 38 O TYR G 89 SHEET 5 AG1 5 LYS G 47 ILE G 50 -1 O MET G 49 N TRP G 37 SHEET 1 AG2 4 SER G 9 SER G 11 0 SHEET 2 AG2 4 THR G 106 THR G 109 1 O THR G 109 N ALA G 10 SHEET 3 AG2 4 ASP G 87 GLY G 95 -1 N TYR G 88 O THR G 106 SHEET 4 AG2 4 PHE G 99 PHE G 102 -1 O PHE G 99 N GLY G 95 SHEET 1 AG3 3 VAL G 18 THR G 23 0 SHEET 2 AG3 3 THR G 72 VAL G 77 -1 O ALA G 73 N CYS G 22 SHEET 3 AG3 3 PHE G 64 SER G 69 -1 N SER G 67 O SER G 74 SSBOND 1 CYS A 278 CYS A 288 1555 1555 2.02 SSBOND 2 CYS A 524 CYS A 576 1555 1555 2.03 SSBOND 3 CYS A 603 CYS A 635 1555 1555 2.12 SSBOND 4 CYS A 648 CYS A 657 1555 1555 2.03 SSBOND 5 CYS A 720 CYS A 742 1555 1555 2.05 SSBOND 6 CYS A 725 CYS A 731 1555 1555 2.03 SSBOND 7 CYS A 822 CYS A 833 1555 1555 2.09 SSBOND 8 CYS A 1014 CYS A 1025 1555 1555 2.01 SSBOND 9 CYS A 1064 CYS A 1108 1555 1555 2.02 SSBOND 10 CYS M 22 CYS M 96 1555 1555 2.02 SSBOND 11 CYS N 22 CYS N 90 1555 1555 2.02 SSBOND 12 CYS B 278 CYS B 288 1555 1555 2.02 SSBOND 13 CYS B 524 CYS B 576 1555 1555 2.03 SSBOND 14 CYS B 603 CYS B 635 1555 1555 2.12 SSBOND 15 CYS B 648 CYS B 657 1555 1555 2.03 SSBOND 16 CYS B 720 CYS B 742 1555 1555 2.05 SSBOND 17 CYS B 725 CYS B 731 1555 1555 2.03 SSBOND 18 CYS B 822 CYS B 833 1555 1555 2.09 SSBOND 19 CYS B 1014 CYS B 1025 1555 1555 2.01 SSBOND 20 CYS B 1064 CYS B 1108 1555 1555 2.02 SSBOND 21 CYS D 22 CYS D 96 1555 1555 2.02 SSBOND 22 CYS F 22 CYS F 90 1555 1555 2.02 SSBOND 23 CYS C 278 CYS C 288 1555 1555 2.02 SSBOND 24 CYS C 524 CYS C 576 1555 1555 2.03 SSBOND 25 CYS C 603 CYS C 635 1555 1555 2.12 SSBOND 26 CYS C 648 CYS C 657 1555 1555 2.03 SSBOND 27 CYS C 720 CYS C 742 1555 1555 2.05 SSBOND 28 CYS C 725 CYS C 731 1555 1555 2.03 SSBOND 29 CYS C 822 CYS C 833 1555 1555 2.09 SSBOND 30 CYS C 1014 CYS C 1025 1555 1555 2.01 SSBOND 31 CYS C 1064 CYS C 1108 1555 1555 2.02 SSBOND 32 CYS E 22 CYS E 96 1555 1555 2.02 SSBOND 33 CYS G 22 CYS G 90 1555 1555 2.02 LINK ND2 ASN A 65 C1 NAG A1301 1555 1555 1.52 LINK ND2 ASN A 269 C1 NAG A1305 1555 1555 1.53 LINK ND2 ASN A 602 C1 NAG A1304 1555 1555 1.53 LINK ND2 ASN A 691 C1 NAG A1302 1555 1555 1.51 LINK ND2 ASN A 699 C1 NAG K 1 1555 1555 1.52 LINK ND2 ASN A 783 C1 NAG J 1 1555 1555 1.51 LINK ND2 ASN A1056 C1 NAG A1303 1555 1555 1.52 LINK ND2 ASN A1080 C1 NAG H 1 1555 1555 1.53 LINK ND2 ASN A1116 C1 NAG I 1 1555 1555 1.52 LINK ND2 ASN B 65 C1 NAG B1301 1555 1555 1.52 LINK ND2 ASN B 269 C1 NAG B1305 1555 1555 1.53 LINK ND2 ASN B 602 C1 NAG B1304 1555 1555 1.53 LINK ND2 ASN B 691 C1 NAG B1302 1555 1555 1.51 LINK ND2 ASN B 699 C1 NAG Q 1 1555 1555 1.52 LINK ND2 ASN B 783 C1 NAG P 1 1555 1555 1.51 LINK ND2 ASN B1056 C1 NAG B1303 1555 1555 1.52 LINK ND2 ASN B1080 C1 NAG L 1 1555 1555 1.53 LINK ND2 ASN B1116 C1 NAG O 1 1555 1555 1.52 LINK ND2 ASN C 65 C1 NAG C1301 1555 1555 1.52 LINK ND2 ASN C 269 C1 NAG C1305 1555 1555 1.53 LINK ND2 ASN C 602 C1 NAG C1304 1555 1555 1.53 LINK ND2 ASN C 691 C1 NAG C1302 1555 1555 1.51 LINK ND2 ASN C 699 C1 NAG U 1 1555 1555 1.52 LINK ND2 ASN C 783 C1 NAG T 1 1555 1555 1.51 LINK ND2 ASN C1056 C1 NAG C1303 1555 1555 1.52 LINK ND2 ASN C1080 C1 NAG R 1 1555 1555 1.53 LINK ND2 ASN C1116 C1 NAG S 1 1555 1555 1.52 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.51 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.52 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.52 LINK O4 NAG J 2 C1 BMA J 3 1555 1555 1.51 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.50 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.51 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.52 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.52 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.52 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.50 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.51 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.52 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.52 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.51 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.50 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000