HEADER IMMUNE SYSTEM 23-JAN-24 8VS8 TITLE CRYSTAL STRUCTURE OF ADI-19425 FAB IN COMPLEX WITH ANTI-IDIOTYPIC 1D3 TITLE 2 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: ADI-19425 HEAVY CHAIN; COMPND 3 CHAIN: A, E, I, M, Q, U, Y, c; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: ADI-19425 LIGHT CHAIN; COMPND 7 CHAIN: B, F, J, N, R, V, Z, d; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: 1D3 LIGHT CHAIN; COMPND 11 CHAIN: C, G, K, O, S, W, a, e; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: 1D3 HEAVY CHAIN; COMPND 15 CHAIN: D, H, L, P, T, X, b, f; COMPND 16 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_COMMON: HUMAN; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 24 ORGANISM_COMMON: HUMAN; SOURCE 25 ORGANISM_TAXID: 9606; SOURCE 26 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 27 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 28 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS RSV, ANTIBODY, ANTI-IDIOTYPE, IMMUNE SYSTEM EXPDTA X-RAY DIFFRACTION AUTHOR G.KHER,L.J.HOMAD,A.T.MCGUIRE,M.PANCERA REVDAT 1 18-SEP-24 8VS8 0 JRNL AUTH S.SCHARFFENBERGER,A.T.MCGUIRE JRNL TITL A NOVEL RSV VACCINE CANDIDATE DERIVED FROM ANTI-IDIOTYPIC JRNL TITL 2 ANTIBODIES TARGETS PUTATIVE NEUTRALIZING B-CELLS IN BULK JRNL TITL 3 PBMCS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.67 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : PHENIX (1.19.2_4158: ???) REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE, REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER, REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY, REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON, REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI, REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART REMARK 3 REMARK 3 REFINEMENT TARGET : ML REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.67 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 49.33 REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.960 REMARK 3 COMPLETENESS FOR RANGE (%) : 92.5 REMARK 3 NUMBER OF REFLECTIONS : 228671 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 R VALUE (WORKING + TEST SET) : 0.233 REMARK 3 R VALUE (WORKING SET) : 0.231 REMARK 3 FREE R VALUE : 0.273 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.030 REMARK 3 FREE R VALUE TEST SET COUNT : 11499 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS). REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE REMARK 3 1 49.3300 - 8.2800 0.92 7182 405 0.2171 0.2292 REMARK 3 2 8.2800 - 6.5800 0.95 7396 422 0.2126 0.2319 REMARK 3 3 6.5800 - 5.7500 0.97 7595 411 0.2142 0.2547 REMARK 3 4 5.7500 - 5.2200 0.87 6858 344 0.1940 0.2228 REMARK 3 5 5.2200 - 4.8500 0.92 7218 373 0.1852 0.2328 REMARK 3 6 4.8500 - 4.5600 0.94 7381 356 0.1759 0.2167 REMARK 3 7 4.5600 - 4.3400 0.96 7463 387 0.1736 0.2101 REMARK 3 8 4.3400 - 4.1500 0.96 7569 336 0.1740 0.2062 REMARK 3 9 4.1500 - 3.9900 0.96 7460 433 0.2018 0.2548 REMARK 3 10 3.9900 - 3.8500 0.96 7559 381 0.2224 0.2689 REMARK 3 11 3.8500 - 3.7300 0.87 6799 352 0.2292 0.2668 REMARK 3 12 3.7300 - 3.6200 0.90 7036 361 0.2365 0.2917 REMARK 3 13 3.6200 - 3.5300 0.91 7057 395 0.2352 0.2669 REMARK 3 14 3.5300 - 3.4400 0.92 7211 427 0.2341 0.2722 REMARK 3 15 3.4400 - 3.3600 0.94 7346 387 0.2493 0.3188 REMARK 3 16 3.3600 - 3.2900 0.94 7278 402 0.2686 0.3203 REMARK 3 17 3.2900 - 3.2300 0.94 7440 341 0.2743 0.3354 REMARK 3 18 3.2300 - 3.1700 0.94 7327 349 0.2763 0.3339 REMARK 3 19 3.1700 - 3.1100 0.94 7422 399 0.2695 0.3148 REMARK 3 20 3.1100 - 3.0600 0.95 7381 394 0.2713 0.3233 REMARK 3 21 3.0600 - 3.0100 0.95 7488 376 0.2831 0.3384 REMARK 3 22 3.0100 - 2.9600 0.95 7352 439 0.2827 0.3459 REMARK 3 23 2.9600 - 2.9200 0.95 7455 376 0.2966 0.3314 REMARK 3 24 2.9200 - 2.8800 0.85 6539 384 0.2963 0.3544 REMARK 3 25 2.8800 - 2.8400 0.86 6776 375 0.3247 0.3676 REMARK 3 26 2.8400 - 2.8000 0.89 6971 378 0.3124 0.3507 REMARK 3 27 2.8000 - 2.7700 0.91 7165 361 0.3114 0.3611 REMARK 3 28 2.7700 - 2.7300 0.91 7054 403 0.3209 0.3673 REMARK 3 29 2.7300 - 2.7000 0.92 7190 373 0.3237 0.3751 REMARK 3 30 2.7000 - 2.6700 0.92 7204 379 0.3325 0.3754 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL REMARK 3 SOLVENT RADIUS : 1.11 REMARK 3 SHRINKAGE RADIUS : 0.90 REMARK 3 K_SOL : NULL REMARK 3 B_SOL : NULL REMARK 3 REMARK 3 ERROR ESTIMATES. REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.440 REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 29.100 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : NULL REMARK 3 B22 (A**2) : NULL REMARK 3 B33 (A**2) : NULL REMARK 3 B12 (A**2) : NULL REMARK 3 B13 (A**2) : NULL REMARK 3 B23 (A**2) : NULL REMARK 3 REMARK 3 TWINNING INFORMATION. REMARK 3 FRACTION: NULL REMARK 3 OPERATOR: NULL REMARK 3 REMARK 3 DEVIATIONS FROM IDEAL VALUES. REMARK 3 RMSD COUNT REMARK 3 BOND : 0.003 45926 REMARK 3 ANGLE : 0.655 62479 REMARK 3 CHIRALITY : 0.044 6967 REMARK 3 PLANARITY : 0.005 7987 REMARK 3 DIHEDRAL : 16.896 16136 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 NCS DETAILS REMARK 3 NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 8VS8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 24-JAN-24. REMARK 100 THE DEPOSITION ID IS D_1000275975. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 08-SEP-22 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : NULL REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : ALS REMARK 200 BEAMLINE : 5.0.2 REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 1.00003 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS3 6M REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : AIMLESS REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 228774 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.670 REMARK 200 RESOLUTION RANGE LOW (A) : 49.450 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 92.5 REMARK 200 DATA REDUNDANCY : 1.900 REMARK 200 R MERGE (I) : 0.10900 REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 4.0000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.67 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.72 REMARK 200 COMPLETENESS FOR SHELL (%) : NULL REMARK 200 DATA REDUNDANCY IN SHELL : 1.90 REMARK 200 R MERGE FOR SHELL (I) : 0.86000 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : NULL REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHENIX REMARK 200 STARTING MODEL: NULL REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 58.54 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.97 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M MES PH 6.5 12% PEG 20K 4% REMARK 280 FORMAMIDE, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 295K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6, 7, 8 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 2 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, G, H REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 3 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: I, J, K, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 4 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: M, N, O, P REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 5 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: Q, R, S, T REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 6 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: U, V, W, X REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 7 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: Y, Z, a, b REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 8 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: c, d, e, f REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER A 127 REMARK 465 SER A 128 REMARK 465 LYS A 129 REMARK 465 SER A 130 REMARK 465 THR A 131 REMARK 465 SER A 132 REMARK 465 GLY A 133 REMARK 465 GLY A 134 REMARK 465 PRO A 185 REMARK 465 SER A 186 REMARK 465 SER A 187 REMARK 465 SER A 188 REMARK 465 LEU A 189 REMARK 465 GLY A 190 REMARK 465 THR A 191 REMARK 465 GLN A 192 REMARK 465 THR A 193 REMARK 465 GLU A 212 REMARK 465 PRO A 213 REMARK 465 LYS A 214 REMARK 465 SER A 215 REMARK 465 CYS A 216 REMARK 465 ASP A 217 REMARK 465 LYS A 218 REMARK 465 PCA B 1 REMARK 465 THR B 209 REMARK 465 GLU B 210 REMARK 465 CYS B 211 REMARK 465 SER B 212 REMARK 465 LYS D 214 REMARK 465 SER D 215 REMARK 465 CYS D 216 REMARK 465 ASP D 217 REMARK 465 LYS D 218 REMARK 465 SER E 128 REMARK 465 LYS E 129 REMARK 465 SER E 130 REMARK 465 THR E 131 REMARK 465 SER E 132 REMARK 465 GLY E 133 REMARK 465 GLY E 134 REMARK 465 PRO E 185 REMARK 465 SER E 186 REMARK 465 SER E 187 REMARK 465 SER E 188 REMARK 465 LEU E 189 REMARK 465 GLY E 190 REMARK 465 THR E 191 REMARK 465 GLN E 192 REMARK 465 THR E 193 REMARK 465 LYS E 214 REMARK 465 SER E 215 REMARK 465 CYS E 216 REMARK 465 ASP E 217 REMARK 465 LYS E 218 REMARK 465 THR F 209 REMARK 465 GLU F 210 REMARK 465 CYS F 211 REMARK 465 SER F 212 REMARK 465 SER H 130 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 SER I 113 REMARK 465 ALA I 114 REMARK 465 SER I 115 REMARK 465 THR I 116 REMARK 465 LYS I 117 REMARK 465 GLY I 118 REMARK 465 PRO I 119 REMARK 465 SER I 120 REMARK 465 VAL I 121 REMARK 465 PHE I 122 REMARK 465 PRO I 123 REMARK 465 LEU I 124 REMARK 465 ALA I 125 REMARK 465 PRO I 126 REMARK 465 SER I 127 REMARK 465 SER I 128 REMARK 465 LYS I 129 REMARK 465 SER I 130 REMARK 465 THR I 131 REMARK 465 SER I 132 REMARK 465 GLY I 133 REMARK 465 GLY I 134 REMARK 465 THR I 135 REMARK 465 ALA I 136 REMARK 465 ALA I 137 REMARK 465 LEU I 138 REMARK 465 GLY I 139 REMARK 465 CYS I 140 REMARK 465 LEU I 141 REMARK 465 VAL I 142 REMARK 465 LYS I 143 REMARK 465 ASP I 144 REMARK 465 TYR I 145 REMARK 465 PHE I 146 REMARK 465 PRO I 147 REMARK 465 GLU I 148 REMARK 465 PRO I 149 REMARK 465 VAL I 150 REMARK 465 THR I 151 REMARK 465 VAL I 152 REMARK 465 SER I 153 REMARK 465 TRP I 154 REMARK 465 ASN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ALA I 158 REMARK 465 LEU I 159 REMARK 465 THR I 160 REMARK 465 SER I 161 REMARK 465 GLY I 162 REMARK 465 VAL I 163 REMARK 465 HIS I 164 REMARK 465 THR I 165 REMARK 465 PHE I 166 REMARK 465 PRO I 167 REMARK 465 ALA I 168 REMARK 465 VAL I 169 REMARK 465 LEU I 170 REMARK 465 GLN I 171 REMARK 465 SER I 172 REMARK 465 SER I 173 REMARK 465 GLY I 174 REMARK 465 LEU I 175 REMARK 465 TYR I 176 REMARK 465 SER I 177 REMARK 465 LEU I 178 REMARK 465 SER I 179 REMARK 465 SER I 180 REMARK 465 VAL I 181 REMARK 465 VAL I 182 REMARK 465 THR I 183 REMARK 465 VAL I 184 REMARK 465 PRO I 185 REMARK 465 SER I 186 REMARK 465 SER I 187 REMARK 465 SER I 188 REMARK 465 LEU I 189 REMARK 465 GLY I 190 REMARK 465 THR I 191 REMARK 465 GLN I 192 REMARK 465 THR I 193 REMARK 465 TYR I 194 REMARK 465 ILE I 195 REMARK 465 CYS I 196 REMARK 465 ASN I 197 REMARK 465 VAL I 198 REMARK 465 ASN I 199 REMARK 465 HIS I 200 REMARK 465 LYS I 201 REMARK 465 PRO I 202 REMARK 465 SER I 203 REMARK 465 ASN I 204 REMARK 465 THR I 205 REMARK 465 LYS I 206 REMARK 465 VAL I 207 REMARK 465 ASP I 208 REMARK 465 LYS I 209 REMARK 465 ARG I 210 REMARK 465 VAL I 211 REMARK 465 GLU I 212 REMARK 465 PRO I 213 REMARK 465 LYS I 214 REMARK 465 SER I 215 REMARK 465 CYS I 216 REMARK 465 ASP I 217 REMARK 465 LYS I 218 REMARK 465 PCA J 1 REMARK 465 LEU J 107 REMARK 465 GLY J 108 REMARK 465 GLN J 109 REMARK 465 PRO J 110 REMARK 465 LYS J 111 REMARK 465 ALA J 112 REMARK 465 ALA J 113 REMARK 465 PRO J 114 REMARK 465 SER J 115 REMARK 465 VAL J 116 REMARK 465 THR J 117 REMARK 465 LEU J 118 REMARK 465 PHE J 119 REMARK 465 PRO J 120 REMARK 465 PRO J 121 REMARK 465 SER J 122 REMARK 465 SER J 123 REMARK 465 GLU J 124 REMARK 465 GLU J 125 REMARK 465 LEU J 126 REMARK 465 GLN J 127 REMARK 465 ALA J 128 REMARK 465 ASN J 129 REMARK 465 LYS J 130 REMARK 465 ALA J 131 REMARK 465 THR J 132 REMARK 465 LEU J 133 REMARK 465 VAL J 134 REMARK 465 CYS J 135 REMARK 465 LEU J 136 REMARK 465 ILE J 137 REMARK 465 SER J 138 REMARK 465 ASP J 139 REMARK 465 PHE J 140 REMARK 465 TYR J 141 REMARK 465 PRO J 142 REMARK 465 GLY J 143 REMARK 465 ALA J 144 REMARK 465 VAL J 145 REMARK 465 THR J 146 REMARK 465 VAL J 147 REMARK 465 ALA J 148 REMARK 465 TRP J 149 REMARK 465 LYS J 150 REMARK 465 ALA J 151 REMARK 465 ASP J 152 REMARK 465 SER J 153 REMARK 465 SER J 154 REMARK 465 PRO J 155 REMARK 465 VAL J 156 REMARK 465 LYS J 157 REMARK 465 ALA J 158 REMARK 465 GLY J 159 REMARK 465 VAL J 160 REMARK 465 GLU J 161 REMARK 465 THR J 162 REMARK 465 THR J 163 REMARK 465 THR J 164 REMARK 465 PRO J 165 REMARK 465 SER J 166 REMARK 465 LYS J 167 REMARK 465 GLN J 168 REMARK 465 SER J 169 REMARK 465 ASN J 170 REMARK 465 ASN J 171 REMARK 465 LYS J 172 REMARK 465 TYR J 173 REMARK 465 ALA J 174 REMARK 465 ALA J 175 REMARK 465 SER J 176 REMARK 465 SER J 177 REMARK 465 TYR J 178 REMARK 465 LEU J 179 REMARK 465 SER J 180 REMARK 465 LEU J 181 REMARK 465 THR J 182 REMARK 465 PRO J 183 REMARK 465 GLU J 184 REMARK 465 GLN J 185 REMARK 465 TRP J 186 REMARK 465 LYS J 187 REMARK 465 SER J 188 REMARK 465 HIS J 189 REMARK 465 ARG J 190 REMARK 465 SER J 191 REMARK 465 TYR J 192 REMARK 465 SER J 193 REMARK 465 CYS J 194 REMARK 465 GLN J 195 REMARK 465 VAL J 196 REMARK 465 THR J 197 REMARK 465 HIS J 198 REMARK 465 GLU J 199 REMARK 465 GLY J 200 REMARK 465 SER J 201 REMARK 465 THR J 202 REMARK 465 VAL J 203 REMARK 465 GLU J 204 REMARK 465 LYS J 205 REMARK 465 THR J 206 REMARK 465 VAL J 207 REMARK 465 ALA J 208 REMARK 465 PRO J 209 REMARK 465 THR J 210 REMARK 465 GLU J 211 REMARK 465 CYS J 212 REMARK 465 SER J 213 REMARK 465 GLU K 213 REMARK 465 CYS K 214 REMARK 465 THR L 131 REMARK 465 SER L 132 REMARK 465 GLY L 133 REMARK 465 LYS L 214 REMARK 465 SER L 215 REMARK 465 CYS L 216 REMARK 465 ASP L 217 REMARK 465 LYS L 218 REMARK 465 SER M 128 REMARK 465 LYS M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 SER M 132 REMARK 465 GLY M 133 REMARK 465 GLY M 134 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 LEU M 189 REMARK 465 GLY M 190 REMARK 465 THR M 191 REMARK 465 LYS M 214 REMARK 465 SER M 215 REMARK 465 CYS M 216 REMARK 465 ASP M 217 REMARK 465 LYS M 218 REMARK 465 THR N 209 REMARK 465 GLU N 210 REMARK 465 CYS N 211 REMARK 465 SER N 212 REMARK 465 SER P 130 REMARK 465 THR P 131 REMARK 465 SER P 132 REMARK 465 GLY P 133 REMARK 465 LYS P 214 REMARK 465 SER P 215 REMARK 465 CYS P 216 REMARK 465 ASP P 217 REMARK 465 LYS P 218 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 LYS Q 129 REMARK 465 SER Q 130 REMARK 465 THR Q 131 REMARK 465 SER Q 132 REMARK 465 GLY Q 133 REMARK 465 GLY Q 134 REMARK 465 THR Q 135 REMARK 465 ALA Q 136 REMARK 465 ALA Q 137 REMARK 465 LEU Q 138 REMARK 465 GLY Q 139 REMARK 465 CYS Q 140 REMARK 465 LEU Q 141 REMARK 465 VAL Q 142 REMARK 465 LYS Q 143 REMARK 465 ASP Q 144 REMARK 465 TYR Q 145 REMARK 465 PHE Q 146 REMARK 465 PRO Q 147 REMARK 465 GLU Q 148 REMARK 465 PRO Q 149 REMARK 465 VAL Q 150 REMARK 465 THR Q 151 REMARK 465 VAL Q 152 REMARK 465 SER Q 153 REMARK 465 TRP Q 154 REMARK 465 ASN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ALA Q 158 REMARK 465 LEU Q 159 REMARK 465 THR Q 160 REMARK 465 SER Q 161 REMARK 465 GLY Q 162 REMARK 465 VAL Q 163 REMARK 465 HIS Q 164 REMARK 465 THR Q 165 REMARK 465 PHE Q 166 REMARK 465 PRO Q 167 REMARK 465 ALA Q 168 REMARK 465 VAL Q 169 REMARK 465 LEU Q 170 REMARK 465 GLN Q 171 REMARK 465 SER Q 172 REMARK 465 SER Q 173 REMARK 465 GLY Q 174 REMARK 465 LEU Q 175 REMARK 465 TYR Q 176 REMARK 465 SER Q 177 REMARK 465 LEU Q 178 REMARK 465 SER Q 179 REMARK 465 SER Q 180 REMARK 465 VAL Q 181 REMARK 465 VAL Q 182 REMARK 465 THR Q 183 REMARK 465 VAL Q 184 REMARK 465 PRO Q 185 REMARK 465 SER Q 186 REMARK 465 SER Q 187 REMARK 465 SER Q 188 REMARK 465 LEU Q 189 REMARK 465 GLY Q 190 REMARK 465 THR Q 191 REMARK 465 GLN Q 192 REMARK 465 THR Q 193 REMARK 465 TYR Q 194 REMARK 465 ILE Q 195 REMARK 465 CYS Q 196 REMARK 465 ASN Q 197 REMARK 465 VAL Q 198 REMARK 465 ASN Q 199 REMARK 465 HIS Q 200 REMARK 465 LYS Q 201 REMARK 465 PRO Q 202 REMARK 465 SER Q 203 REMARK 465 ASN Q 204 REMARK 465 THR Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 ASP Q 208 REMARK 465 LYS Q 209 REMARK 465 ARG Q 210 REMARK 465 VAL Q 211 REMARK 465 GLU Q 212 REMARK 465 PRO Q 213 REMARK 465 LYS Q 214 REMARK 465 SER Q 215 REMARK 465 CYS Q 216 REMARK 465 ASP Q 217 REMARK 465 LYS Q 218 REMARK 465 PCA R 1 REMARK 465 LEU R 94A REMARK 465 GLY R 107 REMARK 465 GLN R 108 REMARK 465 PRO R 109 REMARK 465 LYS R 110 REMARK 465 ALA R 111 REMARK 465 ALA R 112 REMARK 465 PRO R 113 REMARK 465 SER R 114 REMARK 465 VAL R 115 REMARK 465 THR R 116 REMARK 465 LEU R 117 REMARK 465 PHE R 118 REMARK 465 PRO R 119 REMARK 465 PRO R 120 REMARK 465 SER R 121 REMARK 465 SER R 122 REMARK 465 GLU R 123 REMARK 465 GLU R 124 REMARK 465 LEU R 125 REMARK 465 GLN R 126 REMARK 465 ALA R 127 REMARK 465 ASN R 128 REMARK 465 LYS R 129 REMARK 465 ALA R 130 REMARK 465 THR R 131 REMARK 465 LEU R 132 REMARK 465 VAL R 133 REMARK 465 CYS R 134 REMARK 465 LEU R 135 REMARK 465 ILE R 136 REMARK 465 SER R 137 REMARK 465 ASP R 138 REMARK 465 PHE R 139 REMARK 465 TYR R 140 REMARK 465 PRO R 141 REMARK 465 GLY R 142 REMARK 465 ALA R 143 REMARK 465 VAL R 144 REMARK 465 THR R 145 REMARK 465 VAL R 146 REMARK 465 ALA R 147 REMARK 465 TRP R 148 REMARK 465 LYS R 149 REMARK 465 ALA R 150 REMARK 465 ASP R 151 REMARK 465 SER R 152 REMARK 465 SER R 153 REMARK 465 PRO R 154 REMARK 465 VAL R 155 REMARK 465 LYS R 156 REMARK 465 ALA R 157 REMARK 465 GLY R 158 REMARK 465 VAL R 159 REMARK 465 GLU R 160 REMARK 465 THR R 161 REMARK 465 THR R 162 REMARK 465 THR R 163 REMARK 465 PRO R 164 REMARK 465 SER R 165 REMARK 465 LYS R 166 REMARK 465 GLN R 167 REMARK 465 SER R 168 REMARK 465 ASN R 169 REMARK 465 ASN R 170 REMARK 465 LYS R 171 REMARK 465 TYR R 172 REMARK 465 ALA R 173 REMARK 465 ALA R 174 REMARK 465 SER R 175 REMARK 465 SER R 176 REMARK 465 TYR R 177 REMARK 465 LEU R 178 REMARK 465 SER R 179 REMARK 465 LEU R 180 REMARK 465 THR R 181 REMARK 465 PRO R 182 REMARK 465 GLU R 183 REMARK 465 GLN R 184 REMARK 465 TRP R 185 REMARK 465 LYS R 186 REMARK 465 SER R 187 REMARK 465 HIS R 188 REMARK 465 ARG R 189 REMARK 465 SER R 190 REMARK 465 TYR R 191 REMARK 465 SER R 192 REMARK 465 CYS R 193 REMARK 465 GLN R 194 REMARK 465 VAL R 195 REMARK 465 THR R 196 REMARK 465 HIS R 197 REMARK 465 GLU R 198 REMARK 465 GLY R 199 REMARK 465 SER R 200 REMARK 465 THR R 201 REMARK 465 VAL R 202 REMARK 465 GLU R 203 REMARK 465 LYS R 204 REMARK 465 THR R 205 REMARK 465 VAL R 206 REMARK 465 ALA R 207 REMARK 465 PRO R 208 REMARK 465 THR R 209 REMARK 465 GLU R 210 REMARK 465 CYS R 211 REMARK 465 SER R 212 REMARK 465 SER T 127 REMARK 465 SER T 128 REMARK 465 LYS T 129 REMARK 465 SER T 130 REMARK 465 THR T 131 REMARK 465 SER T 132 REMARK 465 GLY T 133 REMARK 465 LYS T 214 REMARK 465 SER T 215 REMARK 465 CYS T 216 REMARK 465 ASP T 217 REMARK 465 LYS T 218 REMARK 465 LEU U 124 REMARK 465 ALA U 125 REMARK 465 PRO U 126 REMARK 465 SER U 127 REMARK 465 SER U 128 REMARK 465 LYS U 129 REMARK 465 SER U 130 REMARK 465 THR U 131 REMARK 465 SER U 132 REMARK 465 GLY U 133 REMARK 465 GLY U 134 REMARK 465 THR U 135 REMARK 465 ALA U 136 REMARK 465 ALA U 137 REMARK 465 LEU U 138 REMARK 465 SER U 153 REMARK 465 TRP U 154 REMARK 465 ASN U 155 REMARK 465 SER U 156 REMARK 465 GLY U 157 REMARK 465 ALA U 158 REMARK 465 LEU U 159 REMARK 465 THR U 160 REMARK 465 SER U 161 REMARK 465 GLY U 162 REMARK 465 VAL U 163 REMARK 465 HIS U 164 REMARK 465 VAL U 182 REMARK 465 THR U 183 REMARK 465 VAL U 184 REMARK 465 PRO U 185 REMARK 465 SER U 186 REMARK 465 SER U 187 REMARK 465 SER U 188 REMARK 465 LEU U 189 REMARK 465 GLY U 190 REMARK 465 THR U 191 REMARK 465 GLN U 192 REMARK 465 THR U 193 REMARK 465 TYR U 194 REMARK 465 ILE U 195 REMARK 465 VAL U 211 REMARK 465 GLU U 212 REMARK 465 PRO U 213 REMARK 465 LYS U 214 REMARK 465 SER U 215 REMARK 465 CYS U 216 REMARK 465 ASP U 217 REMARK 465 LYS U 218 REMARK 465 ALA V 150 REMARK 465 ASP V 151 REMARK 465 SER V 152 REMARK 465 SER V 153 REMARK 465 PRO V 154 REMARK 465 VAL V 155 REMARK 465 LYS V 156 REMARK 465 ALA V 157 REMARK 465 LEU V 180 REMARK 465 GLU V 183 REMARK 465 ARG V 189 REMARK 465 SER V 190 REMARK 465 TYR V 191 REMARK 465 THR V 209 REMARK 465 GLU V 210 REMARK 465 CYS V 211 REMARK 465 SER V 212 REMARK 465 LYS W 149 REMARK 465 VAL W 150 REMARK 465 ASP W 151 REMARK 465 ASN W 152 REMARK 465 ALA W 153 REMARK 465 LEU W 154 REMARK 465 VAL W 191 REMARK 465 TYR W 192 REMARK 465 ALA W 193 REMARK 465 ASN W 210 REMARK 465 ARG W 211 REMARK 465 GLY W 212 REMARK 465 GLU W 213 REMARK 465 CYS W 214 REMARK 465 SER X 127 REMARK 465 SER X 128 REMARK 465 LYS X 129 REMARK 465 GLY X 133 REMARK 465 GLN X 192 REMARK 465 LYS X 214 REMARK 465 SER X 215 REMARK 465 CYS X 216 REMARK 465 ASP X 217 REMARK 465 LYS X 218 REMARK 465 SER Y 113 REMARK 465 ALA Y 114 REMARK 465 SER Y 115 REMARK 465 THR Y 116 REMARK 465 LYS Y 117 REMARK 465 GLY Y 118 REMARK 465 PRO Y 119 REMARK 465 SER Y 120 REMARK 465 VAL Y 121 REMARK 465 PHE Y 122 REMARK 465 PRO Y 123 REMARK 465 LEU Y 124 REMARK 465 ALA Y 125 REMARK 465 PRO Y 126 REMARK 465 SER Y 127 REMARK 465 SER Y 128 REMARK 465 LYS Y 129 REMARK 465 SER Y 130 REMARK 465 THR Y 131 REMARK 465 SER Y 132 REMARK 465 GLY Y 133 REMARK 465 GLY Y 134 REMARK 465 THR Y 135 REMARK 465 ALA Y 136 REMARK 465 ALA Y 137 REMARK 465 LEU Y 138 REMARK 465 GLY Y 139 REMARK 465 CYS Y 140 REMARK 465 LEU Y 141 REMARK 465 VAL Y 142 REMARK 465 LYS Y 143 REMARK 465 ASP Y 144 REMARK 465 TYR Y 145 REMARK 465 PHE Y 146 REMARK 465 PRO Y 147 REMARK 465 GLU Y 148 REMARK 465 PRO Y 149 REMARK 465 VAL Y 150 REMARK 465 THR Y 151 REMARK 465 VAL Y 152 REMARK 465 SER Y 153 REMARK 465 TRP Y 154 REMARK 465 ASN Y 155 REMARK 465 SER Y 156 REMARK 465 GLY Y 157 REMARK 465 ALA Y 158 REMARK 465 LEU Y 159 REMARK 465 THR Y 160 REMARK 465 SER Y 161 REMARK 465 GLY Y 162 REMARK 465 VAL Y 163 REMARK 465 HIS Y 164 REMARK 465 THR Y 165 REMARK 465 PHE Y 166 REMARK 465 PRO Y 167 REMARK 465 ALA Y 168 REMARK 465 VAL Y 169 REMARK 465 LEU Y 170 REMARK 465 GLN Y 171 REMARK 465 SER Y 172 REMARK 465 SER Y 173 REMARK 465 GLY Y 174 REMARK 465 LEU Y 175 REMARK 465 TYR Y 176 REMARK 465 SER Y 177 REMARK 465 LEU Y 178 REMARK 465 SER Y 179 REMARK 465 SER Y 180 REMARK 465 VAL Y 181 REMARK 465 VAL Y 182 REMARK 465 THR Y 183 REMARK 465 VAL Y 184 REMARK 465 PRO Y 185 REMARK 465 SER Y 186 REMARK 465 SER Y 187 REMARK 465 SER Y 188 REMARK 465 LEU Y 189 REMARK 465 GLY Y 190 REMARK 465 THR Y 191 REMARK 465 GLN Y 192 REMARK 465 THR Y 193 REMARK 465 TYR Y 194 REMARK 465 ILE Y 195 REMARK 465 CYS Y 196 REMARK 465 ASN Y 197 REMARK 465 VAL Y 198 REMARK 465 ASN Y 199 REMARK 465 HIS Y 200 REMARK 465 LYS Y 201 REMARK 465 PRO Y 202 REMARK 465 SER Y 203 REMARK 465 ASN Y 204 REMARK 465 THR Y 205 REMARK 465 LYS Y 206 REMARK 465 VAL Y 207 REMARK 465 ASP Y 208 REMARK 465 LYS Y 209 REMARK 465 ARG Y 210 REMARK 465 VAL Y 211 REMARK 465 GLU Y 212 REMARK 465 PRO Y 213 REMARK 465 LYS Y 214 REMARK 465 SER Y 215 REMARK 465 CYS Y 216 REMARK 465 ASP Y 217 REMARK 465 LYS Y 218 REMARK 465 PCA Z 1 REMARK 465 SER Z 12 REMARK 465 GLY Z 13 REMARK 465 LEU Z 107 REMARK 465 GLY Z 108 REMARK 465 GLN Z 109 REMARK 465 PRO Z 110 REMARK 465 LYS Z 111 REMARK 465 ALA Z 112 REMARK 465 ALA Z 113 REMARK 465 PRO Z 114 REMARK 465 SER Z 115 REMARK 465 VAL Z 116 REMARK 465 THR Z 117 REMARK 465 LEU Z 118 REMARK 465 PHE Z 119 REMARK 465 PRO Z 120 REMARK 465 PRO Z 121 REMARK 465 SER Z 122 REMARK 465 SER Z 123 REMARK 465 GLU Z 124 REMARK 465 GLU Z 125 REMARK 465 LEU Z 126 REMARK 465 GLN Z 127 REMARK 465 ALA Z 128 REMARK 465 ASN Z 129 REMARK 465 LYS Z 130 REMARK 465 ALA Z 131 REMARK 465 THR Z 132 REMARK 465 LEU Z 133 REMARK 465 VAL Z 134 REMARK 465 CYS Z 135 REMARK 465 LEU Z 136 REMARK 465 ILE Z 137 REMARK 465 SER Z 138 REMARK 465 ASP Z 139 REMARK 465 PHE Z 140 REMARK 465 TYR Z 141 REMARK 465 PRO Z 142 REMARK 465 GLY Z 143 REMARK 465 ALA Z 144 REMARK 465 VAL Z 145 REMARK 465 THR Z 146 REMARK 465 VAL Z 147 REMARK 465 ALA Z 148 REMARK 465 TRP Z 149 REMARK 465 LYS Z 150 REMARK 465 ALA Z 151 REMARK 465 ASP Z 152 REMARK 465 SER Z 153 REMARK 465 SER Z 154 REMARK 465 PRO Z 155 REMARK 465 VAL Z 156 REMARK 465 LYS Z 157 REMARK 465 ALA Z 158 REMARK 465 GLY Z 159 REMARK 465 VAL Z 160 REMARK 465 GLU Z 161 REMARK 465 THR Z 162 REMARK 465 THR Z 163 REMARK 465 THR Z 164 REMARK 465 PRO Z 165 REMARK 465 SER Z 166 REMARK 465 LYS Z 167 REMARK 465 GLN Z 168 REMARK 465 SER Z 169 REMARK 465 ASN Z 170 REMARK 465 ASN Z 171 REMARK 465 LYS Z 172 REMARK 465 TYR Z 173 REMARK 465 ALA Z 174 REMARK 465 ALA Z 175 REMARK 465 SER Z 176 REMARK 465 SER Z 177 REMARK 465 TYR Z 178 REMARK 465 LEU Z 179 REMARK 465 SER Z 180 REMARK 465 LEU Z 181 REMARK 465 THR Z 182 REMARK 465 PRO Z 183 REMARK 465 GLU Z 184 REMARK 465 GLN Z 185 REMARK 465 TRP Z 186 REMARK 465 LYS Z 187 REMARK 465 SER Z 188 REMARK 465 HIS Z 189 REMARK 465 ARG Z 190 REMARK 465 SER Z 191 REMARK 465 TYR Z 192 REMARK 465 SER Z 193 REMARK 465 CYS Z 194 REMARK 465 GLN Z 195 REMARK 465 VAL Z 196 REMARK 465 THR Z 197 REMARK 465 HIS Z 198 REMARK 465 GLU Z 199 REMARK 465 GLY Z 200 REMARK 465 SER Z 201 REMARK 465 THR Z 202 REMARK 465 VAL Z 203 REMARK 465 GLU Z 204 REMARK 465 LYS Z 205 REMARK 465 THR Z 206 REMARK 465 VAL Z 207 REMARK 465 ALA Z 208 REMARK 465 PRO Z 209 REMARK 465 THR Z 210 REMARK 465 GLU Z 211 REMARK 465 CYS Z 212 REMARK 465 SER Z 213 REMARK 465 SER b 128 REMARK 465 LYS b 129 REMARK 465 SER b 130 REMARK 465 LYS b 214 REMARK 465 SER b 215 REMARK 465 CYS b 216 REMARK 465 ASP b 217 REMARK 465 LYS b 218 REMARK 465 GLU c 1 REMARK 465 GLY c 16 REMARK 465 SER c 17 REMARK 465 LEU c 18 REMARK 465 SER c 33 REMARK 465 MET c 34 REMARK 465 LYS c 43 REMARK 465 THR c 68 REMARK 465 ARG c 71 REMARK 465 ASP c 72 REMARK 465 ASN c 73 REMARK 465 ALA c 74 REMARK 465 VAL c 89 REMARK 465 TYR c 90 REMARK 465 SER c 98A REMARK 465 GLY c 98B REMARK 465 GLY c 98C REMARK 465 HIS c 100D REMARK 465 PHE c 100E REMARK 465 ASP c 100F REMARK 465 THR c 107 REMARK 465 LEU c 108 REMARK 465 SER c 112 REMARK 465 SER c 113 REMARK 465 ALA c 114 REMARK 465 SER c 115 REMARK 465 THR c 116 REMARK 465 LYS c 117 REMARK 465 GLY c 118 REMARK 465 PRO c 119 REMARK 465 SER c 120 REMARK 465 VAL c 121 REMARK 465 PHE c 122 REMARK 465 PRO c 123 REMARK 465 LEU c 124 REMARK 465 ALA c 125 REMARK 465 PRO c 126 REMARK 465 SER c 127 REMARK 465 SER c 128 REMARK 465 LYS c 129 REMARK 465 SER c 130 REMARK 465 THR c 131 REMARK 465 SER c 132 REMARK 465 GLY c 133 REMARK 465 GLY c 134 REMARK 465 THR c 135 REMARK 465 ALA c 136 REMARK 465 ALA c 137 REMARK 465 LEU c 138 REMARK 465 GLY c 139 REMARK 465 CYS c 140 REMARK 465 LEU c 141 REMARK 465 VAL c 142 REMARK 465 LYS c 143 REMARK 465 ASP c 144 REMARK 465 TYR c 145 REMARK 465 PHE c 146 REMARK 465 PRO c 147 REMARK 465 GLU c 148 REMARK 465 PRO c 149 REMARK 465 VAL c 150 REMARK 465 THR c 151 REMARK 465 VAL c 152 REMARK 465 SER c 153 REMARK 465 TRP c 154 REMARK 465 ASN c 155 REMARK 465 SER c 156 REMARK 465 GLY c 157 REMARK 465 ALA c 158 REMARK 465 LEU c 159 REMARK 465 THR c 160 REMARK 465 SER c 161 REMARK 465 GLY c 162 REMARK 465 VAL c 163 REMARK 465 HIS c 164 REMARK 465 THR c 165 REMARK 465 PHE c 166 REMARK 465 PRO c 167 REMARK 465 ALA c 168 REMARK 465 VAL c 169 REMARK 465 LEU c 170 REMARK 465 GLN c 171 REMARK 465 SER c 172 REMARK 465 SER c 173 REMARK 465 GLY c 174 REMARK 465 LEU c 175 REMARK 465 TYR c 176 REMARK 465 SER c 177 REMARK 465 LEU c 178 REMARK 465 SER c 179 REMARK 465 SER c 180 REMARK 465 VAL c 181 REMARK 465 VAL c 182 REMARK 465 THR c 183 REMARK 465 VAL c 184 REMARK 465 PRO c 185 REMARK 465 SER c 186 REMARK 465 SER c 187 REMARK 465 SER c 188 REMARK 465 LEU c 189 REMARK 465 GLY c 190 REMARK 465 THR c 191 REMARK 465 GLN c 192 REMARK 465 THR c 193 REMARK 465 TYR c 194 REMARK 465 ILE c 195 REMARK 465 CYS c 196 REMARK 465 ASN c 197 REMARK 465 VAL c 198 REMARK 465 ASN c 199 REMARK 465 HIS c 200 REMARK 465 LYS c 201 REMARK 465 PRO c 202 REMARK 465 SER c 203 REMARK 465 ASN c 204 REMARK 465 THR c 205 REMARK 465 LYS c 206 REMARK 465 VAL c 207 REMARK 465 ASP c 208 REMARK 465 LYS c 209 REMARK 465 ARG c 210 REMARK 465 VAL c 211 REMARK 465 GLU c 212 REMARK 465 PRO c 213 REMARK 465 LYS c 214 REMARK 465 SER c 215 REMARK 465 CYS c 216 REMARK 465 ASP c 217 REMARK 465 LYS c 218 REMARK 465 PCA d 1 REMARK 465 PRO d 2 REMARK 465 SER d 10 REMARK 465 VAL d 11 REMARK 465 SER d 12 REMARK 465 GLY d 13 REMARK 465 ALA d 14 REMARK 465 PRO d 15 REMARK 465 GLY d 16 REMARK 465 GLN d 17 REMARK 465 HIS d 34 REMARK 465 LEU d 39 REMARK 465 ASP d 60 REMARK 465 ARG d 61 REMARK 465 SER d 65 REMARK 465 LYS d 66 REMARK 465 SER d 67 REMARK 465 THR d 76 REMARK 465 GLY d 77 REMARK 465 ALA d 84 REMARK 465 ASP d 85 REMARK 465 LEU d 94A REMARK 465 SER d 94B REMARK 465 GLY d 94C REMARK 465 PHE d 94D REMARK 465 THR d 102 REMARK 465 LYS d 103 REMARK 465 LEU d 104 REMARK 465 THR d 105 REMARK 465 VAL d 106 REMARK 465 LEU d 107 REMARK 465 GLY d 108 REMARK 465 GLN d 109 REMARK 465 PRO d 110 REMARK 465 LYS d 111 REMARK 465 ALA d 112 REMARK 465 ALA d 113 REMARK 465 PRO d 114 REMARK 465 SER d 115 REMARK 465 VAL d 116 REMARK 465 THR d 117 REMARK 465 LEU d 118 REMARK 465 PHE d 119 REMARK 465 PRO d 120 REMARK 465 PRO d 121 REMARK 465 SER d 122 REMARK 465 SER d 123 REMARK 465 GLU d 124 REMARK 465 GLU d 125 REMARK 465 LEU d 126 REMARK 465 GLN d 127 REMARK 465 ALA d 128 REMARK 465 ASN d 129 REMARK 465 LYS d 130 REMARK 465 ALA d 131 REMARK 465 THR d 132 REMARK 465 LEU d 133 REMARK 465 VAL d 134 REMARK 465 CYS d 135 REMARK 465 LEU d 136 REMARK 465 ILE d 137 REMARK 465 SER d 138 REMARK 465 ASP d 139 REMARK 465 PHE d 140 REMARK 465 TYR d 141 REMARK 465 PRO d 142 REMARK 465 GLY d 143 REMARK 465 ALA d 144 REMARK 465 VAL d 145 REMARK 465 THR d 146 REMARK 465 VAL d 147 REMARK 465 ALA d 148 REMARK 465 TRP d 149 REMARK 465 LYS d 150 REMARK 465 ALA d 151 REMARK 465 ASP d 152 REMARK 465 SER d 153 REMARK 465 SER d 154 REMARK 465 PRO d 155 REMARK 465 VAL d 156 REMARK 465 LYS d 157 REMARK 465 ALA d 158 REMARK 465 GLY d 159 REMARK 465 VAL d 160 REMARK 465 GLU d 161 REMARK 465 THR d 162 REMARK 465 THR d 163 REMARK 465 THR d 164 REMARK 465 PRO d 165 REMARK 465 SER d 166 REMARK 465 LYS d 167 REMARK 465 GLN d 168 REMARK 465 SER d 169 REMARK 465 ASN d 170 REMARK 465 ASN d 171 REMARK 465 LYS d 172 REMARK 465 TYR d 173 REMARK 465 ALA d 174 REMARK 465 ALA d 175 REMARK 465 SER d 176 REMARK 465 SER d 177 REMARK 465 TYR d 178 REMARK 465 LEU d 179 REMARK 465 SER d 180 REMARK 465 LEU d 181 REMARK 465 THR d 182 REMARK 465 PRO d 183 REMARK 465 GLU d 184 REMARK 465 GLN d 185 REMARK 465 TRP d 186 REMARK 465 LYS d 187 REMARK 465 SER d 188 REMARK 465 HIS d 189 REMARK 465 ARG d 190 REMARK 465 SER d 191 REMARK 465 TYR d 192 REMARK 465 SER d 193 REMARK 465 CYS d 194 REMARK 465 GLN d 195 REMARK 465 VAL d 196 REMARK 465 THR d 197 REMARK 465 HIS d 198 REMARK 465 GLU d 199 REMARK 465 GLY d 200 REMARK 465 SER d 201 REMARK 465 THR d 202 REMARK 465 VAL d 203 REMARK 465 GLU d 204 REMARK 465 LYS d 205 REMARK 465 THR d 206 REMARK 465 VAL d 207 REMARK 465 ALA d 208 REMARK 465 PRO d 209 REMARK 465 THR d 210 REMARK 465 GLU d 211 REMARK 465 CYS d 212 REMARK 465 SER d 213 REMARK 465 PCA f 1 REMARK 465 LYS f 129 REMARK 465 SER f 130 REMARK 465 THR f 131 REMARK 465 SER f 132 REMARK 465 GLY f 133 REMARK 465 LYS f 214 REMARK 465 SER f 215 REMARK 465 CYS f 216 REMARK 465 ASP f 217 REMARK 465 LYS f 218 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 GLU A 1 CG CD OE1 OE2 REMARK 470 LEU A 138 CG CD1 CD2 REMARK 470 ARG A 210 CG CD NE CZ NH1 NH2 REMARK 470 LEU B 180 CG CD1 CD2 REMARK 470 GLU B 183 CG CD OE1 OE2 REMARK 470 LYS B 186 CG CD CE NZ REMARK 470 LYS C 145 CG CD CE NZ REMARK 470 GLN C 147 CG CD OE1 NE2 REMARK 470 LYS G 145 CG CD CE NZ REMARK 470 GLU G 213 CG CD OE1 OE2 REMARK 470 ARG H 210 CG CD NE CZ NH1 NH2 REMARK 470 GLN J 17 CG CD OE1 NE2 REMARK 470 TYR L 74 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 GLU L 212 CG CD OE1 OE2 REMARK 470 ARG N 189 CG CD NE CZ NH1 NH2 REMARK 470 LYS Q 13 CG CD CE NZ REMARK 470 ARG S 24 CG CD NE CZ NH1 NH2 REMARK 470 LYS S 190 CG CD CE NZ REMARK 470 GLN V 126 CG CD OE1 NE2 REMARK 470 LYS X 143 CG CD CE NZ REMARK 470 LYS Z 66 CG CD CE NZ REMARK 470 LYS a 107 CG CD CE NZ REMARK 470 LYS a 126 CG CD CE NZ REMARK 470 LYS a 149 CG CD CE NZ REMARK 470 LYS e 49 CG CD CE NZ REMARK 470 ARG e 108 CG CD NE CZ NH1 NH2 REMARK 470 LYS e 149 CG CD CE NZ REMARK 470 GLU e 165 CG CD OE1 OE2 REMARK 470 LYS e 188 CG CD CE NZ REMARK 470 GLN f 5 CG CD OE1 NE2 REMARK 470 ARG f 13 CG CD NE CZ NH1 NH2 REMARK 470 LYS f 64 CG CD CE NZ REMARK 470 LYS f 201 CG CD CE NZ REMARK 470 LYS f 206 CG CD CE NZ REMARK 470 GLU f 212 CG CD OE1 OE2 REMARK 480 REMARK 480 ZERO OCCUPANCY ATOM REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME; REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 480 M RES C SSEQI ATOMS REMARK 480 LEU B 106A C REMARK 480 SER D 82A O REMARK 480 ASP D 100A N OD1 REMARK 480 GLY D 100B O REMARK 480 PRO D 100C C CG REMARK 480 PHE D 100D N CB CD2 REMARK 480 LEU F 106A CD1 REMARK 480 SER L 52A CA C REMARK 480 LEU N 106A CD1 REMARK 480 SER P 82B O CB REMARK 480 LEU P 82C CD1 REMARK 480 SER T 52A CA C REMARK 480 PRO b 100C C CB REMARK 480 PHE b 100D O CD2 CE1 REMARK 480 SER f 52A OG REMARK 480 SER f 82A OG REMARK 480 SER f 82B N REMARK 480 LEU f 82C CD2 REMARK 480 GLY f 100B N REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500 REMARK 500 DISTANCE CUTOFF: REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 NH2 ARG R 54 O GLU e 187 1454 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LYS A 43 -169.76 -123.06 REMARK 500 VAL A 48 -63.22 -104.80 REMARK 500 SER A 100B 125.01 66.84 REMARK 500 SER A 113 -145.87 58.30 REMARK 500 ALA A 114 109.79 60.30 REMARK 500 ASP A 144 83.95 54.43 REMARK 500 PHE A 146 123.44 -170.39 REMARK 500 PRO A 147 -163.93 -105.53 REMARK 500 ASN B 27B -93.80 -121.66 REMARK 500 ASN B 51 -55.76 68.89 REMARK 500 LEU B 95 -135.00 56.58 REMARK 500 LEU B 106A 98.99 -63.46 REMARK 500 GLN B 108 144.50 -172.20 REMARK 500 ALA B 130 117.68 -161.03 REMARK 500 ASP B 151 -115.87 59.38 REMARK 500 ASN B 170 -1.60 66.06 REMARK 500 GLU B 198 -109.61 55.34 REMARK 500 PRO C 15 109.08 -56.24 REMARK 500 ILE C 29 -3.40 -144.53 REMARK 500 ASP C 30 -120.44 65.19 REMARK 500 ALA C 51 -45.52 71.21 REMARK 500 SER C 65 -22.11 -147.41 REMARK 500 ASN C 138 71.57 54.18 REMARK 500 LYS C 190 -50.92 -129.13 REMARK 500 SER D 82B 71.30 24.74 REMARK 500 LEU D 98 -36.58 68.11 REMARK 500 SER D 132 77.16 -69.42 REMARK 500 ASP D 144 75.86 59.16 REMARK 500 LYS E 43 -169.55 -120.93 REMARK 500 VAL E 48 -60.15 -108.67 REMARK 500 SER E 99 -72.59 -87.63 REMARK 500 SER E 100B 131.56 65.73 REMARK 500 ASP E 144 80.59 54.42 REMARK 500 PRO E 147 -159.51 -101.19 REMARK 500 ASN F 27B -91.97 -119.81 REMARK 500 ASN F 51 -61.76 65.12 REMARK 500 ALA F 143 119.16 -163.38 REMARK 500 ASP F 151 -95.56 56.69 REMARK 500 ASN F 170 -4.10 66.07 REMARK 500 GLU F 198 -100.10 56.90 REMARK 500 ILE G 29 -9.45 -140.82 REMARK 500 ASP G 30 -118.66 66.12 REMARK 500 ALA G 51 -44.81 66.22 REMARK 500 ASN G 138 78.90 54.10 REMARK 500 LYS G 169 -67.36 -95.41 REMARK 500 HIS H 43 -163.17 -120.62 REMARK 500 LEU H 98 -35.31 69.30 REMARK 500 SER H 127 -167.68 -116.02 REMARK 500 ASP H 144 75.39 59.09 REMARK 500 THR H 191 -71.10 -107.15 REMARK 500 REMARK 500 THIS ENTRY HAS 199 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL DBREF 8VS8 A 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 B 1 212 PDB 8VS8 8VS8 1 212 DBREF 8VS8 C 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 D 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 E 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 F 1 212 PDB 8VS8 8VS8 1 212 DBREF 8VS8 G 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 H 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 I 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 J 1 213 PDB 8VS8 8VS8 1 213 DBREF 8VS8 K 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 L 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 M 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 N 1 212 PDB 8VS8 8VS8 1 212 DBREF 8VS8 O 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 P 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 Q 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 R 1 212 PDB 8VS8 8VS8 1 212 DBREF 8VS8 S 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 T 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 U 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 V 1 212 PDB 8VS8 8VS8 1 212 DBREF 8VS8 W 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 X 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 Y 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 Z 1 213 PDB 8VS8 8VS8 1 213 DBREF 8VS8 a 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 b 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 c 1 218 PDB 8VS8 8VS8 1 218 DBREF 8VS8 d 1 213 PDB 8VS8 8VS8 1 213 DBREF 8VS8 e 1 214 PDB 8VS8 8VS8 1 214 DBREF 8VS8 f 1 218 PDB 8VS8 8VS8 1 218 SEQRES 1 A 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 A 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 A 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 A 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 A 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 A 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 A 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 A 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 A 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 A 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 A 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 A 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 A 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 A 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 A 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 A 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 A 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 A 227 PRO LYS SER CYS ASP LYS SEQRES 1 B 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 B 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 B 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 B 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 B 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 B 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 B 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 B 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 B 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 B 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 B 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 B 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 B 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 B 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 B 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 B 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 B 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 C 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 C 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 C 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 C 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 C 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 C 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 C 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 C 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 C 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 C 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 C 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 C 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 C 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 C 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 C 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 C 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 C 214 PHE ASN ARG GLY GLU CYS SEQRES 1 D 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 D 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 D 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 D 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 D 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 D 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 D 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 D 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 D 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 D 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 D 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 D 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 D 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 D 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 D 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 D 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 D 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 D 226 LYS SER CYS ASP LYS SEQRES 1 E 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 E 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 E 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 E 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 E 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 E 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 E 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 E 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 E 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 E 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 E 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 E 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 E 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 E 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 E 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 E 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 E 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 E 227 PRO LYS SER CYS ASP LYS SEQRES 1 F 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 F 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 F 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 F 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 F 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 F 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 F 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 F 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 F 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 F 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 F 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 F 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 F 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 F 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 F 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 F 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 F 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 G 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 G 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 G 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 G 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 G 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 G 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 G 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 G 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 G 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 G 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 G 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 G 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 G 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 G 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 G 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 G 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 G 214 PHE ASN ARG GLY GLU CYS SEQRES 1 H 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 H 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 H 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 H 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 H 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 H 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 H 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 H 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 H 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 H 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 H 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 H 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 H 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 H 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 H 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 H 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 H 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 H 226 LYS SER CYS ASP LYS SEQRES 1 I 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 I 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 I 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 I 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 I 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 I 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 I 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 I 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 I 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 I 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 I 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 I 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 I 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 I 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 I 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 I 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 I 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 I 227 PRO LYS SER CYS ASP LYS SEQRES 1 J 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 J 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 J 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 J 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 J 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 J 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 J 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 J 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 J 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 J 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 J 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 J 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 J 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 J 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 J 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 J 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 J 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 K 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 K 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 K 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 K 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 K 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 K 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 K 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 K 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 K 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 K 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 K 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 K 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 K 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 K 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 K 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 K 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 K 214 PHE ASN ARG GLY GLU CYS SEQRES 1 L 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 L 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 L 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 L 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 L 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 L 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 L 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 L 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 L 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 L 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 L 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 L 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 L 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 L 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 L 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 L 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 L 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 L 226 LYS SER CYS ASP LYS SEQRES 1 M 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 M 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 M 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 M 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 M 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 M 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 M 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 M 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 M 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 M 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 M 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 M 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 M 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 M 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 M 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 M 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 M 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 M 227 PRO LYS SER CYS ASP LYS SEQRES 1 N 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 N 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 N 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 N 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 N 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 N 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 N 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 N 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 N 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 N 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 N 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 N 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 N 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 N 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 N 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 N 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 N 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 O 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 O 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 O 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 O 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 O 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 O 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 O 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 O 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 O 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 O 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 O 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 O 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 O 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 O 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 O 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 O 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 O 214 PHE ASN ARG GLY GLU CYS SEQRES 1 P 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 P 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 P 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 P 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 P 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 P 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 P 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 P 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 P 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 P 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 P 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 P 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 P 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 P 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 P 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 P 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 P 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 P 226 LYS SER CYS ASP LYS SEQRES 1 Q 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 Q 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 Q 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 Q 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 Q 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 Q 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 Q 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 Q 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 Q 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 Q 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 Q 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 Q 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 Q 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 Q 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 Q 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 Q 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 Q 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 Q 227 PRO LYS SER CYS ASP LYS SEQRES 1 R 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 R 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 R 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 R 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 R 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 R 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 R 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 R 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 R 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 R 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 R 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 R 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 R 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 R 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 R 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 R 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 R 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 S 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 S 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 S 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 S 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 S 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 S 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 S 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 S 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 S 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 S 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 S 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 S 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 S 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 S 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 S 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 S 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 S 214 PHE ASN ARG GLY GLU CYS SEQRES 1 T 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 T 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 T 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 T 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 T 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 T 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 T 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 T 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 T 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 T 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 T 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 T 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 T 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 T 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 T 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 T 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 T 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 T 226 LYS SER CYS ASP LYS SEQRES 1 U 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 U 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 U 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 U 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 U 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 U 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 U 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 U 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 U 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 U 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 U 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 U 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 U 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 U 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 U 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 U 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 U 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 U 227 PRO LYS SER CYS ASP LYS SEQRES 1 V 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 V 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 V 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 V 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 V 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 V 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 V 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 V 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 V 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 V 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 V 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 V 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 V 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 V 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 V 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 V 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 V 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 W 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 W 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 W 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 W 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 W 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 W 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 W 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 W 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 W 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 W 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 W 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 W 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 W 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 W 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 W 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 W 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 W 214 PHE ASN ARG GLY GLU CYS SEQRES 1 X 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 X 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 X 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 X 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 X 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 X 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 X 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 X 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 X 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 X 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 X 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 X 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 X 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 X 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 X 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 X 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 X 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 X 226 LYS SER CYS ASP LYS SEQRES 1 Y 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 Y 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 Y 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 Y 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 Y 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 Y 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 Y 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 Y 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 Y 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 Y 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 Y 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 Y 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 Y 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 Y 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 Y 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 Y 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 Y 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 Y 227 PRO LYS SER CYS ASP LYS SEQRES 1 Z 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 Z 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 Z 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 Z 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 Z 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 Z 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 Z 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 Z 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 Z 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 Z 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 Z 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 Z 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 Z 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 Z 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 Z 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 Z 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 Z 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 a 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 a 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 a 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 a 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 a 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 a 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 a 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 a 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 a 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 a 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 a 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 a 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 a 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 a 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 a 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 a 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 a 214 PHE ASN ARG GLY GLU CYS SEQRES 1 b 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 b 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 b 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 b 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 b 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 b 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 b 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 b 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 b 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 b 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 b 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 b 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 b 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 b 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 b 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 b 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 b 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 b 226 LYS SER CYS ASP LYS SEQRES 1 c 227 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 c 227 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 c 227 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 c 227 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 c 227 SER SER SER SER TYR ILE TYR TYR ALA ASP SER VAL LYS SEQRES 6 c 227 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 c 227 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 c 227 ALA VAL TYR TYR CYS ALA ARG LEU GLY TYR CYS SER GLY SEQRES 9 c 227 GLY SER CYS HIS PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 10 c 227 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 c 227 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 c 227 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 c 227 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 c 227 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 c 227 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 c 227 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 c 227 HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU SEQRES 18 c 227 PRO LYS SER CYS ASP LYS SEQRES 1 d 218 PCA PRO VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 d 218 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 d 218 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 d 218 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE TYR GLY SEQRES 5 d 218 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 d 218 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 d 218 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 d 218 SER TYR ASP SER SER LEU SER GLY PHE TYR VAL PHE GLY SEQRES 9 d 218 THR GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA SEQRES 10 d 218 ALA PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU SEQRES 11 d 218 LEU GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER SEQRES 12 d 218 ASP PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA SEQRES 13 d 218 ASP SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR SEQRES 14 d 218 PRO SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER SEQRES 15 d 218 TYR LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SEQRES 16 d 218 SER TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL SEQRES 17 d 218 GLU LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 e 214 ASP ILE LEU LEU THR GLN SER PRO ALA ILE LEU SER VAL SEQRES 2 e 214 SER PRO GLY GLU ARG VAL SER PHE SER CYS ARG ALA SER SEQRES 3 e 214 GLN ASN ILE ASP THR HIS ILE HIS TRP TYR GLN GLN ARG SEQRES 4 e 214 THR ASN GLY SER PRO ARG LEU LEU ILE LYS TYR ALA SER SEQRES 5 e 214 GLU SER ILE SER GLY ILE PRO SER ARG PHE SER GLY SER SEQRES 6 e 214 GLY SER GLY THR ASP PHE THR LEU THR ILE ASN SER VAL SEQRES 7 e 214 GLU SER GLU ASP ILE ALA ASP TYR TYR CYS GLN GLN SER SEQRES 8 e 214 ASN SER TRP PRO PHE THR PHE GLY SER GLY THR LYS LEU SEQRES 9 e 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 e 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 e 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 e 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 e 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 e 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 e 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 e 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 e 214 PHE ASN ARG GLY GLU CYS SEQRES 1 f 226 PCA VAL GLN ILE GLN GLN SER GLY ALA GLU LEU MET ARG SEQRES 2 f 226 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA THR GLY SEQRES 3 f 226 TYR THR PHE THR GLY TYR TRP ILE GLU TRP VAL LYS GLN SEQRES 4 f 226 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU SEQRES 5 f 226 SER GLY ARG GLY THR THR ASN TYR ASN GLU LYS PHE LYS SEQRES 6 f 226 GLY LYS ALA THR PHE THR ALA ASP THR TYR SER ASN THR SEQRES 7 f 226 ALA TYR MET GLN LEU SER SER LEU THR THR GLY ASP SER SEQRES 8 f 226 ALA ILE TYR TYR CYS ALA ARG GLY GLY PHE LEU TYR GLY SEQRES 9 f 226 ASP GLY PRO PHE ASP TYR TRP GLY GLN GLY THR THR LEU SEQRES 10 f 226 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 f 226 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 f 226 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 f 226 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 f 226 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 f 226 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 f 226 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 f 226 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 f 226 LYS SER CYS ASP LYS HET PCA D 1 8 HET PCA F 1 8 HET PCA H 1 8 HET PCA L 1 8 HET PCA N 1 8 HET PCA P 1 8 HET PCA T 1 8 HET PCA V 1 8 HET PCA X 1 8 HET PCA b 1 8 HETNAM PCA PYROGLUTAMIC ACID FORMUL 4 PCA 10(C5 H7 N O3) FORMUL 33 HOH *178(H2 O) HELIX 1 AA1 THR A 28 TYR A 32 5 5 HELIX 2 AA2 ARG A 83 THR A 87 5 5 HELIX 3 AA3 ASN B 27B GLY B 30 5 5 HELIX 4 AA4 GLN B 79 GLU B 83 5 5 HELIX 5 AA5 SER B 121 ALA B 127 1 7 HELIX 6 AA6 THR B 181 SER B 187 1 7 HELIX 7 AA7 GLU C 79 ILE C 83 5 5 HELIX 8 AA8 SER C 121 LYS C 126 1 6 HELIX 9 AA9 LYS C 183 LYS C 188 1 6 HELIX 10 AB1 THR D 83 SER D 87 5 5 HELIX 11 AB2 SER D 187 LEU D 189 5 3 HELIX 12 AB3 LYS D 201 ASN D 204 5 4 HELIX 13 AB4 THR E 28 TYR E 32 5 5 HELIX 14 AB5 ARG E 83 THR E 87 5 5 HELIX 15 AB6 SER E 156 ALA E 158 5 3 HELIX 16 AB7 ASN F 27B GLY F 30 5 5 HELIX 17 AB8 GLN F 79 GLU F 83 5 5 HELIX 18 AB9 SER F 121 ALA F 127 1 7 HELIX 19 AC1 THR F 181 HIS F 188 1 8 HELIX 20 AC2 GLU G 79 ILE G 83 5 5 HELIX 21 AC3 SER G 121 LYS G 126 1 6 HELIX 22 AC4 LYS G 183 GLU G 187 1 5 HELIX 23 AC5 THR H 83 SER H 87 5 5 HELIX 24 AC6 SER H 156 ALA H 158 5 3 HELIX 25 AC7 SER H 187 LEU H 189 5 3 HELIX 26 AC8 LYS H 201 ASN H 204 5 4 HELIX 27 AC9 THR I 28 TYR I 32 5 5 HELIX 28 AD1 ARG I 83 THR I 87 5 5 HELIX 29 AD2 GLU K 79 ILE K 83 5 5 HELIX 30 AD3 SER K 121 LYS K 126 1 6 HELIX 31 AD4 LYS K 183 LYS K 188 1 6 HELIX 32 AD5 THR L 83 SER L 87 5 5 HELIX 33 AD6 SER L 156 ALA L 158 5 3 HELIX 34 AD7 SER L 187 LEU L 189 5 3 HELIX 35 AD8 LYS L 201 ASN L 204 5 4 HELIX 36 AD9 THR M 28 TYR M 32 5 5 HELIX 37 AE1 ARG M 83 THR M 87 5 5 HELIX 38 AE2 SER M 156 ALA M 158 5 3 HELIX 39 AE3 LYS M 201 ASN M 204 5 4 HELIX 40 AE4 GLN N 79 GLU N 83 5 5 HELIX 41 AE5 SER N 121 ALA N 127 1 7 HELIX 42 AE6 THR N 181 HIS N 188 1 8 HELIX 43 AE7 GLU O 79 ILE O 83 5 5 HELIX 44 AE8 SER O 121 SER O 127 1 7 HELIX 45 AE9 LYS O 183 GLU O 187 1 5 HELIX 46 AF1 GLU P 61 LYS P 64 5 4 HELIX 47 AF2 SER P 156 ALA P 158 5 3 HELIX 48 AF3 SER P 187 LEU P 189 5 3 HELIX 49 AF4 LYS P 201 ASN P 204 5 4 HELIX 50 AF5 THR Q 28 TYR Q 32 5 5 HELIX 51 AF6 ASN Q 73 LYS Q 75 5 3 HELIX 52 AF7 ARG Q 83 THR Q 87 5 5 HELIX 53 AF8 ASN R 27B GLY R 30 5 5 HELIX 54 AF9 GLN R 79 GLU R 83 5 5 HELIX 55 AG1 GLU S 79 ILE S 83 5 5 HELIX 56 AG2 SER S 121 LYS S 126 1 6 HELIX 57 AG3 LYS S 183 GLU S 187 1 5 HELIX 58 AG4 THR T 83 SER T 87 5 5 HELIX 59 AG5 SER T 156 ALA T 158 5 3 HELIX 60 AG6 LYS T 201 ASN T 204 5 4 HELIX 61 AG7 THR U 28 TYR U 32 5 5 HELIX 62 AG8 ARG U 83 THR U 87 5 5 HELIX 63 AG9 HIS U 200 ASN U 204 5 5 HELIX 64 AH1 ASN V 27B GLY V 30 5 5 HELIX 65 AH2 GLN V 79 GLU V 83 5 5 HELIX 66 AH3 SER V 121 ALA V 127 1 7 HELIX 67 AH4 SER W 121 SER W 127 1 7 HELIX 68 AH5 LYS W 183 GLU W 187 1 5 HELIX 69 AH6 GLU X 61 LYS X 64 5 4 HELIX 70 AH7 THR X 83 SER X 87 5 5 HELIX 71 AH8 SER X 156 ALA X 158 5 3 HELIX 72 AH9 SER X 187 LEU X 189 5 3 HELIX 73 AI1 THR Y 28 TYR Y 32 5 5 HELIX 74 AI2 ARG Y 83 THR Y 87 5 5 HELIX 75 AI3 ASN Z 27B GLY Z 30 5 5 HELIX 76 AI4 GLU a 79 ILE a 83 5 5 HELIX 77 AI5 GLN a 124 SER a 127 5 4 HELIX 78 AI6 LYS a 183 LYS a 188 1 6 HELIX 79 AI7 GLU b 61 LYS b 64 5 4 HELIX 80 AI8 THR b 83 SER b 87 5 5 HELIX 81 AI9 SER b 156 ALA b 158 5 3 HELIX 82 AJ1 SER b 187 LEU b 189 5 3 HELIX 83 AJ2 LYS b 201 ASN b 204 5 4 HELIX 84 AJ3 THR c 28 TYR c 32 5 5 HELIX 85 AJ4 ALA c 60 LYS c 64 5 5 HELIX 86 AJ5 ARG c 83 THR c 87 5 5 HELIX 87 AJ6 GLN d 79 GLU d 83 5 5 HELIX 88 AJ7 SER e 121 GLY e 128 1 8 HELIX 89 AJ8 LYS e 183 GLU e 187 1 5 HELIX 90 AJ9 GLU f 61 LYS f 64 5 4 HELIX 91 AK1 THR f 83 SER f 87 5 5 HELIX 92 AK2 SER f 156 ALA f 158 5 3 HELIX 93 AK3 LYS f 201 ASN f 204 5 4 SHEET 1 AA1 4 GLN A 3 SER A 7 0 SHEET 2 AA1 4 LEU A 18 SER A 25 -1 O SER A 21 N SER A 7 SHEET 3 AA1 4 SER A 77 MET A 82 -1 O LEU A 78 N CYS A 22 SHEET 4 AA1 4 PHE A 67 ASP A 72 -1 N SER A 70 O TYR A 79 SHEET 1 AA2 6 GLY A 10 VAL A 12 0 SHEET 2 AA2 6 THR A 107 VAL A 111 1 O THR A 110 N VAL A 12 SHEET 3 AA2 6 ALA A 88 LEU A 95 -1 N TYR A 90 O THR A 107 SHEET 4 AA2 6 SER A 33 GLN A 39 -1 N VAL A 37 O TYR A 91 SHEET 5 AA2 6 LEU A 45 ILE A 51 -1 O VAL A 48 N TRP A 36 SHEET 6 AA2 6 ILE A 57 TYR A 59 -1 O TYR A 58 N SER A 50 SHEET 1 AA3 4 GLY A 10 VAL A 12 0 SHEET 2 AA3 4 THR A 107 VAL A 111 1 O THR A 110 N VAL A 12 SHEET 3 AA3 4 ALA A 88 LEU A 95 -1 N TYR A 90 O THR A 107 SHEET 4 AA3 4 PHE A 100E TRP A 103 -1 O TYR A 102 N ARG A 94 SHEET 1 AA4 4 SER A 120 LEU A 124 0 SHEET 2 AA4 4 ALA A 136 TYR A 145 -1 O LYS A 143 N SER A 120 SHEET 3 AA4 4 TYR A 176 VAL A 184 -1 O LEU A 178 N VAL A 142 SHEET 4 AA4 4 VAL A 163 LEU A 170 -1 N HIS A 164 O VAL A 181 SHEET 1 AA5 3 VAL A 150 TRP A 154 0 SHEET 2 AA5 3 ILE A 195 HIS A 200 -1 O ASN A 197 N SER A 153 SHEET 3 AA5 3 THR A 205 ARG A 210 -1 O THR A 205 N HIS A 200 SHEET 1 AA6 5 SER B 9 GLY B 13 0 SHEET 2 AA6 5 THR B 102 VAL B 106 1 O LYS B 103 N VAL B 11 SHEET 3 AA6 5 ASP B 85 ASP B 92 -1 N TYR B 86 O THR B 102 SHEET 4 AA6 5 HIS B 34 GLN B 38 -1 N GLN B 38 O ASP B 85 SHEET 5 AA6 5 LYS B 45 ILE B 48 -1 O LYS B 45 N GLN B 37 SHEET 1 AA7 4 SER B 9 GLY B 13 0 SHEET 2 AA7 4 THR B 102 VAL B 106 1 O LYS B 103 N VAL B 11 SHEET 3 AA7 4 ASP B 85 ASP B 92 -1 N TYR B 86 O THR B 102 SHEET 4 AA7 4 PHE B 95C PHE B 98 -1 O PHE B 95C N ASP B 92 SHEET 1 AA8 3 VAL B 19 THR B 24 0 SHEET 2 AA8 3 SER B 70 ILE B 75 -1 O ALA B 71 N CYS B 23 SHEET 3 AA8 3 PHE B 62 SER B 67 -1 N SER B 67 O SER B 70 SHEET 1 AA9 4 SER B 114 PHE B 118 0 SHEET 2 AA9 4 ALA B 130 PHE B 139 -1 O SER B 137 N SER B 114 SHEET 3 AA9 4 TYR B 172 LEU B 180 -1 O ALA B 174 N ILE B 136 SHEET 4 AA9 4 VAL B 159 THR B 161 -1 N GLU B 160 O TYR B 177 SHEET 1 AB1 4 SER B 114 PHE B 118 0 SHEET 2 AB1 4 ALA B 130 PHE B 139 -1 O SER B 137 N SER B 114 SHEET 3 AB1 4 TYR B 172 LEU B 180 -1 O ALA B 174 N ILE B 136 SHEET 4 AB1 4 SER B 165 LYS B 166 -1 N SER B 165 O ALA B 173 SHEET 1 AB2 4 SER B 153 VAL B 155 0 SHEET 2 AB2 4 THR B 145 ALA B 150 -1 N TRP B 148 O VAL B 155 SHEET 3 AB2 4 TYR B 191 HIS B 197 -1 O GLN B 194 N ALA B 147 SHEET 4 AB2 4 SER B 200 VAL B 206 -1 O VAL B 206 N TYR B 191 SHEET 1 AB3 4 LEU C 4 THR C 5 0 SHEET 2 AB3 4 VAL C 19 ALA C 25 -1 O ARG C 24 N THR C 5 SHEET 3 AB3 4 ASP C 70 ILE C 75 -1 O PHE C 71 N CYS C 23 SHEET 4 AB3 4 PHE C 62 GLY C 64 -1 N SER C 63 O THR C 74 SHEET 1 AB4 6 ILE C 10 VAL C 13 0 SHEET 2 AB4 6 THR C 102 ILE C 106 1 O LYS C 103 N LEU C 11 SHEET 3 AB4 6 ASP C 85 GLN C 90 -1 N TYR C 86 O THR C 102 SHEET 4 AB4 6 ILE C 33 GLN C 38 -1 N GLN C 38 O ASP C 85 SHEET 5 AB4 6 ARG C 45 LYS C 49 -1 O LEU C 47 N TRP C 35 SHEET 6 AB4 6 GLU C 53 SER C 54 -1 O GLU C 53 N LYS C 49 SHEET 1 AB5 4 ILE C 10 VAL C 13 0 SHEET 2 AB5 4 THR C 102 ILE C 106 1 O LYS C 103 N LEU C 11 SHEET 3 AB5 4 ASP C 85 GLN C 90 -1 N TYR C 86 O THR C 102 SHEET 4 AB5 4 THR C 97 PHE C 98 -1 O THR C 97 N GLN C 90 SHEET 1 AB6 4 SER C 114 PHE C 118 0 SHEET 2 AB6 4 THR C 129 PHE C 139 -1 O LEU C 135 N PHE C 116 SHEET 3 AB6 4 TYR C 173 SER C 182 -1 O LEU C 181 N ALA C 130 SHEET 4 AB6 4 SER C 159 VAL C 163 -1 N GLN C 160 O THR C 178 SHEET 1 AB7 4 ALA C 153 LEU C 154 0 SHEET 2 AB7 4 LYS C 145 VAL C 150 -1 N VAL C 150 O ALA C 153 SHEET 3 AB7 4 VAL C 191 THR C 197 -1 O GLU C 195 N GLN C 147 SHEET 4 AB7 4 VAL C 205 ASN C 210 -1 O VAL C 205 N VAL C 196 SHEET 1 AB8 4 GLN D 3 GLN D 6 0 SHEET 2 AB8 4 VAL D 18 THR D 25 -1 O THR D 25 N GLN D 3 SHEET 3 AB8 4 THR D 77 LEU D 82 -1 O MET D 80 N LEU D 20 SHEET 4 AB8 4 ALA D 67 ASP D 72 -1 N THR D 70 O TYR D 79 SHEET 1 AB9 6 GLU D 10 MET D 12 0 SHEET 2 AB9 6 THR D 107 VAL D 111 1 O THR D 110 N GLU D 10 SHEET 3 AB9 6 ALA D 88 PHE D 97 -1 N ALA D 88 O LEU D 109 SHEET 4 AB9 6 TYR D 32 GLN D 39 -1 N TRP D 33 O GLY D 95 SHEET 5 AB9 6 LEU D 45 LEU D 52 -1 O GLU D 46 N LYS D 38 SHEET 6 AB9 6 THR D 57 TYR D 59 -1 O ASN D 58 N GLU D 50 SHEET 1 AC1 4 GLU D 10 MET D 12 0 SHEET 2 AC1 4 THR D 107 VAL D 111 1 O THR D 110 N GLU D 10 SHEET 3 AC1 4 ALA D 88 PHE D 97 -1 N ALA D 88 O LEU D 109 SHEET 4 AC1 4 TYR D 102 TRP D 103 -1 O TYR D 102 N ARG D 94 SHEET 1 AC2 4 SER D 120 LEU D 124 0 SHEET 2 AC2 4 THR D 135 TYR D 145 -1 O LEU D 141 N PHE D 122 SHEET 3 AC2 4 TYR D 176 PRO D 185 -1 O TYR D 176 N TYR D 145 SHEET 4 AC2 4 VAL D 163 THR D 165 -1 N HIS D 164 O VAL D 181 SHEET 1 AC3 4 SER D 120 LEU D 124 0 SHEET 2 AC3 4 THR D 135 TYR D 145 -1 O LEU D 141 N PHE D 122 SHEET 3 AC3 4 TYR D 176 PRO D 185 -1 O TYR D 176 N TYR D 145 SHEET 4 AC3 4 VAL D 169 LEU D 170 -1 N VAL D 169 O SER D 177 SHEET 1 AC4 3 THR D 151 TRP D 154 0 SHEET 2 AC4 3 TYR D 194 HIS D 200 -1 O ASN D 197 N SER D 153 SHEET 3 AC4 3 THR D 205 VAL D 211 -1 O VAL D 207 N VAL D 198 SHEET 1 AC5 4 GLN E 3 SER E 7 0 SHEET 2 AC5 4 LEU E 18 SER E 25 -1 O ALA E 23 N VAL E 5 SHEET 3 AC5 4 SER E 77 MET E 82 -1 O MET E 82 N LEU E 18 SHEET 4 AC5 4 PHE E 67 ASP E 72 -1 N THR E 68 O GLN E 81 SHEET 1 AC6 6 LEU E 11 VAL E 12 0 SHEET 2 AC6 6 THR E 107 VAL E 111 1 O THR E 110 N VAL E 12 SHEET 3 AC6 6 ALA E 88 LEU E 95 -1 N TYR E 90 O THR E 107 SHEET 4 AC6 6 SER E 33 GLN E 39 -1 N VAL E 37 O TYR E 91 SHEET 5 AC6 6 LEU E 45 ILE E 51 -1 O SER E 49 N TRP E 36 SHEET 6 AC6 6 ILE E 57 TYR E 59 -1 O TYR E 58 N SER E 50 SHEET 1 AC7 4 LEU E 11 VAL E 12 0 SHEET 2 AC7 4 THR E 107 VAL E 111 1 O THR E 110 N VAL E 12 SHEET 3 AC7 4 ALA E 88 LEU E 95 -1 N TYR E 90 O THR E 107 SHEET 4 AC7 4 PHE E 100E TRP E 103 -1 O TYR E 102 N ARG E 94 SHEET 1 AC8 4 SER E 120 LEU E 124 0 SHEET 2 AC8 4 ALA E 137 TYR E 145 -1 O LYS E 143 N SER E 120 SHEET 3 AC8 4 TYR E 176 THR E 183 -1 O TYR E 176 N TYR E 145 SHEET 4 AC8 4 VAL E 163 THR E 165 -1 N HIS E 164 O VAL E 181 SHEET 1 AC9 4 SER E 120 LEU E 124 0 SHEET 2 AC9 4 ALA E 137 TYR E 145 -1 O LYS E 143 N SER E 120 SHEET 3 AC9 4 TYR E 176 THR E 183 -1 O TYR E 176 N TYR E 145 SHEET 4 AC9 4 VAL E 169 LEU E 170 -1 N VAL E 169 O SER E 177 SHEET 1 AD1 3 VAL E 150 TRP E 154 0 SHEET 2 AD1 3 ILE E 195 HIS E 200 -1 O ASN E 197 N SER E 153 SHEET 3 AD1 3 THR E 205 ARG E 210 -1 O THR E 205 N HIS E 200 SHEET 1 AD2 5 SER F 9 GLY F 13 0 SHEET 2 AD2 5 THR F 102 VAL F 106 1 O THR F 105 N VAL F 11 SHEET 3 AD2 5 ALA F 84 ASP F 92 -1 N TYR F 86 O THR F 102 SHEET 4 AD2 5 HIS F 34 GLN F 38 -1 N HIS F 34 O GLN F 89 SHEET 5 AD2 5 LYS F 45 ILE F 48 -1 O LYS F 45 N GLN F 37 SHEET 1 AD3 4 SER F 9 GLY F 13 0 SHEET 2 AD3 4 THR F 102 VAL F 106 1 O THR F 105 N VAL F 11 SHEET 3 AD3 4 ALA F 84 ASP F 92 -1 N TYR F 86 O THR F 102 SHEET 4 AD3 4 PHE F 95C PHE F 98 -1 O PHE F 95C N ASP F 92 SHEET 1 AD4 3 VAL F 19 THR F 24 0 SHEET 2 AD4 3 SER F 70 ILE F 75 -1 O LEU F 73 N ILE F 21 SHEET 3 AD4 3 PHE F 62 SER F 67 -1 N SER F 63 O ALA F 74 SHEET 1 AD5 4 SER F 114 PHE F 118 0 SHEET 2 AD5 4 ALA F 130 PHE F 139 -1 O SER F 137 N SER F 114 SHEET 3 AD5 4 TYR F 172 LEU F 180 -1 O ALA F 174 N ILE F 136 SHEET 4 AD5 4 VAL F 159 THR F 161 -1 N GLU F 160 O TYR F 177 SHEET 1 AD6 4 SER F 114 PHE F 118 0 SHEET 2 AD6 4 ALA F 130 PHE F 139 -1 O SER F 137 N SER F 114 SHEET 3 AD6 4 TYR F 172 LEU F 180 -1 O ALA F 174 N ILE F 136 SHEET 4 AD6 4 SER F 165 LYS F 166 -1 N SER F 165 O ALA F 173 SHEET 1 AD7 4 SER F 153 VAL F 155 0 SHEET 2 AD7 4 VAL F 144 ALA F 150 -1 N ALA F 150 O SER F 153 SHEET 3 AD7 4 TYR F 191 HIS F 197 -1 O GLN F 194 N ALA F 147 SHEET 4 AD7 4 SER F 200 VAL F 206 -1 O VAL F 202 N VAL F 195 SHEET 1 AD8 4 LEU G 4 SER G 7 0 SHEET 2 AD8 4 VAL G 19 ALA G 25 -1 O ARG G 24 N THR G 5 SHEET 3 AD8 4 ASP G 70 ILE G 75 -1 O ILE G 75 N VAL G 19 SHEET 4 AD8 4 PHE G 62 SER G 67 -1 N SER G 63 O THR G 74 SHEET 1 AD9 6 ILE G 10 VAL G 13 0 SHEET 2 AD9 6 THR G 102 ILE G 106 1 O GLU G 105 N VAL G 13 SHEET 3 AD9 6 ASP G 85 GLN G 90 -1 N TYR G 86 O THR G 102 SHEET 4 AD9 6 ILE G 33 GLN G 38 -1 N HIS G 34 O GLN G 89 SHEET 5 AD9 6 ARG G 45 LYS G 49 -1 O LEU G 47 N TRP G 35 SHEET 6 AD9 6 GLU G 53 SER G 54 -1 O GLU G 53 N LYS G 49 SHEET 1 AE1 4 ILE G 10 VAL G 13 0 SHEET 2 AE1 4 THR G 102 ILE G 106 1 O GLU G 105 N VAL G 13 SHEET 3 AE1 4 ASP G 85 GLN G 90 -1 N TYR G 86 O THR G 102 SHEET 4 AE1 4 THR G 97 PHE G 98 -1 O THR G 97 N GLN G 90 SHEET 1 AE2 4 SER G 114 PHE G 118 0 SHEET 2 AE2 4 THR G 129 PHE G 139 -1 O LEU G 135 N PHE G 116 SHEET 3 AE2 4 TYR G 173 SER G 182 -1 O LEU G 181 N ALA G 130 SHEET 4 AE2 4 SER G 159 VAL G 163 -1 N GLN G 160 O THR G 178 SHEET 1 AE3 3 LYS G 145 VAL G 150 0 SHEET 2 AE3 3 VAL G 191 THR G 197 -1 O GLU G 195 N GLN G 147 SHEET 3 AE3 3 VAL G 205 ASN G 210 -1 O VAL G 205 N VAL G 196 SHEET 1 AE4 4 GLN H 3 GLN H 6 0 SHEET 2 AE4 4 VAL H 18 THR H 25 -1 O THR H 25 N GLN H 3 SHEET 3 AE4 4 THR H 77 LEU H 82 -1 O MET H 80 N LEU H 20 SHEET 4 AE4 4 ALA H 67 ASP H 72 -1 N THR H 70 O TYR H 79 SHEET 1 AE5 6 GLU H 10 MET H 12 0 SHEET 2 AE5 6 THR H 107 VAL H 111 1 O THR H 108 N GLU H 10 SHEET 3 AE5 6 ALA H 88 PHE H 97 -1 N TYR H 90 O THR H 107 SHEET 4 AE5 6 TYR H 32 GLN H 39 -1 N TRP H 33 O GLY H 95 SHEET 5 AE5 6 GLU H 46 LEU H 52 -1 O GLU H 46 N LYS H 38 SHEET 6 AE5 6 THR H 57 TYR H 59 -1 O ASN H 58 N GLU H 50 SHEET 1 AE6 4 GLU H 10 MET H 12 0 SHEET 2 AE6 4 THR H 107 VAL H 111 1 O THR H 108 N GLU H 10 SHEET 3 AE6 4 ALA H 88 PHE H 97 -1 N TYR H 90 O THR H 107 SHEET 4 AE6 4 TYR H 102 TRP H 103 -1 O TYR H 102 N ARG H 94 SHEET 1 AE7 4 SER H 120 LEU H 124 0 SHEET 2 AE7 4 THR H 135 TYR H 145 -1 O GLY H 139 N LEU H 124 SHEET 3 AE7 4 TYR H 176 PRO H 185 -1 O LEU H 178 N VAL H 142 SHEET 4 AE7 4 VAL H 163 THR H 165 -1 N HIS H 164 O VAL H 181 SHEET 1 AE8 4 SER H 120 LEU H 124 0 SHEET 2 AE8 4 THR H 135 TYR H 145 -1 O GLY H 139 N LEU H 124 SHEET 3 AE8 4 TYR H 176 PRO H 185 -1 O LEU H 178 N VAL H 142 SHEET 4 AE8 4 VAL H 169 LEU H 170 -1 N VAL H 169 O SER H 177 SHEET 1 AE9 3 THR H 151 TRP H 154 0 SHEET 2 AE9 3 TYR H 194 HIS H 200 -1 O ASN H 197 N SER H 153 SHEET 3 AE9 3 THR H 205 VAL H 211 -1 O VAL H 207 N VAL H 198 SHEET 1 AF1 4 GLN I 3 SER I 7 0 SHEET 2 AF1 4 LEU I 18 SER I 25 -1 O SER I 25 N GLN I 3 SHEET 3 AF1 4 SER I 77 MET I 82 -1 O MET I 82 N LEU I 18 SHEET 4 AF1 4 PHE I 67 ASP I 72 -1 N SER I 70 O TYR I 79 SHEET 1 AF2 6 GLY I 10 VAL I 12 0 SHEET 2 AF2 6 THR I 107 VAL I 111 1 O THR I 110 N GLY I 10 SHEET 3 AF2 6 ALA I 88 LEU I 95 -1 N TYR I 90 O THR I 107 SHEET 4 AF2 6 SER I 33 GLN I 39 -1 N VAL I 37 O TYR I 91 SHEET 5 AF2 6 GLU I 46 ILE I 51 -1 O VAL I 48 N TRP I 36 SHEET 6 AF2 6 ILE I 57 TYR I 59 -1 O TYR I 58 N SER I 50 SHEET 1 AF3 4 GLY I 10 VAL I 12 0 SHEET 2 AF3 4 THR I 107 VAL I 111 1 O THR I 110 N GLY I 10 SHEET 3 AF3 4 ALA I 88 LEU I 95 -1 N TYR I 90 O THR I 107 SHEET 4 AF3 4 PHE I 100E TRP I 103 -1 O TYR I 102 N ARG I 94 SHEET 1 AF4 5 SER J 9 SER J 12 0 SHEET 2 AF4 5 THR J 102 THR J 105 1 O LYS J 103 N VAL J 11 SHEET 3 AF4 5 ASP J 85 ASP J 92 -1 N TYR J 86 O THR J 102 SHEET 4 AF4 5 HIS J 34 GLN J 38 -1 N HIS J 34 O GLN J 89 SHEET 5 AF4 5 LYS J 45 ILE J 48 -1 O ILE J 48 N TRP J 35 SHEET 1 AF5 4 SER J 9 SER J 12 0 SHEET 2 AF5 4 THR J 102 THR J 105 1 O LYS J 103 N VAL J 11 SHEET 3 AF5 4 ASP J 85 ASP J 92 -1 N TYR J 86 O THR J 102 SHEET 4 AF5 4 PHE J 95C PHE J 98 -1 O PHE J 95C N ASP J 92 SHEET 1 AF6 3 VAL J 19 THR J 24 0 SHEET 2 AF6 3 SER J 70 ILE J 75 -1 O LEU J 73 N ILE J 21 SHEET 3 AF6 3 PHE J 62 SER J 67 -1 N SER J 63 O ALA J 74 SHEET 1 AF7 4 LEU K 4 THR K 5 0 SHEET 2 AF7 4 VAL K 19 ALA K 25 -1 O ARG K 24 N THR K 5 SHEET 3 AF7 4 ASP K 70 ILE K 75 -1 O ILE K 75 N VAL K 19 SHEET 4 AF7 4 PHE K 62 GLY K 64 -1 N SER K 63 O THR K 74 SHEET 1 AF8 5 ILE K 10 VAL K 13 0 SHEET 2 AF8 5 THR K 102 ILE K 106 1 O GLU K 105 N VAL K 13 SHEET 3 AF8 5 ASP K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AF8 5 ILE K 33 GLN K 38 -1 N GLN K 38 O ASP K 85 SHEET 5 AF8 5 ARG K 45 ILE K 48 -1 O ILE K 48 N TRP K 35 SHEET 1 AF9 4 ILE K 10 VAL K 13 0 SHEET 2 AF9 4 THR K 102 ILE K 106 1 O GLU K 105 N VAL K 13 SHEET 3 AF9 4 ASP K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AF9 4 THR K 97 PHE K 98 -1 O THR K 97 N GLN K 90 SHEET 1 AG1 4 SER K 114 PHE K 118 0 SHEET 2 AG1 4 THR K 129 PHE K 139 -1 O LEU K 135 N PHE K 116 SHEET 3 AG1 4 TYR K 173 SER K 182 -1 O LEU K 179 N VAL K 132 SHEET 4 AG1 4 SER K 159 VAL K 163 -1 N GLN K 160 O THR K 178 SHEET 1 AG2 4 ALA K 153 LEU K 154 0 SHEET 2 AG2 4 ALA K 144 VAL K 150 -1 N VAL K 150 O ALA K 153 SHEET 3 AG2 4 VAL K 191 HIS K 198 -1 O GLU K 195 N GLN K 147 SHEET 4 AG2 4 VAL K 205 ASN K 210 -1 O VAL K 205 N VAL K 196 SHEET 1 AG3 4 GLN L 3 GLN L 6 0 SHEET 2 AG3 4 VAL L 18 THR L 25 -1 O LYS L 23 N GLN L 5 SHEET 3 AG3 4 THR L 77 LEU L 82 -1 O MET L 80 N LEU L 20 SHEET 4 AG3 4 ALA L 67 ASP L 72 -1 N THR L 70 O TYR L 79 SHEET 1 AG4 6 GLU L 10 MET L 12 0 SHEET 2 AG4 6 THR L 107 VAL L 111 1 O THR L 110 N MET L 12 SHEET 3 AG4 6 ALA L 88 PHE L 97 -1 N TYR L 90 O THR L 107 SHEET 4 AG4 6 TYR L 32 GLN L 39 -1 N TRP L 33 O GLY L 95 SHEET 5 AG4 6 GLU L 46 LEU L 52 -1 O GLU L 46 N LYS L 38 SHEET 6 AG4 6 THR L 57 TYR L 59 -1 O ASN L 58 N GLU L 50 SHEET 1 AG5 4 GLU L 10 MET L 12 0 SHEET 2 AG5 4 THR L 107 VAL L 111 1 O THR L 110 N MET L 12 SHEET 3 AG5 4 ALA L 88 PHE L 97 -1 N TYR L 90 O THR L 107 SHEET 4 AG5 4 PHE L 100D TRP L 103 -1 O TYR L 102 N ARG L 94 SHEET 1 AG6 4 SER L 120 LEU L 124 0 SHEET 2 AG6 4 THR L 135 TYR L 145 -1 O LEU L 141 N PHE L 122 SHEET 3 AG6 4 TYR L 176 PRO L 185 -1 O VAL L 184 N ALA L 136 SHEET 4 AG6 4 VAL L 163 THR L 165 -1 N HIS L 164 O VAL L 181 SHEET 1 AG7 4 SER L 120 LEU L 124 0 SHEET 2 AG7 4 THR L 135 TYR L 145 -1 O LEU L 141 N PHE L 122 SHEET 3 AG7 4 TYR L 176 PRO L 185 -1 O VAL L 184 N ALA L 136 SHEET 4 AG7 4 VAL L 169 LEU L 170 -1 N VAL L 169 O SER L 177 SHEET 1 AG8 3 THR L 151 TRP L 154 0 SHEET 2 AG8 3 TYR L 194 HIS L 200 -1 O ASN L 197 N SER L 153 SHEET 3 AG8 3 THR L 205 VAL L 211 -1 O VAL L 207 N VAL L 198 SHEET 1 AG9 4 GLN M 3 SER M 7 0 SHEET 2 AG9 4 LEU M 18 SER M 25 -1 O SER M 21 N SER M 7 SHEET 3 AG9 4 SER M 77 MET M 82 -1 O MET M 82 N LEU M 18 SHEET 4 AG9 4 PHE M 67 ASP M 72 -1 N SER M 70 O TYR M 79 SHEET 1 AH1 6 GLY M 10 VAL M 12 0 SHEET 2 AH1 6 THR M 107 VAL M 111 1 O THR M 110 N GLY M 10 SHEET 3 AH1 6 ALA M 88 LEU M 95 -1 N TYR M 90 O THR M 107 SHEET 4 AH1 6 SER M 33 GLN M 39 -1 N VAL M 37 O TYR M 91 SHEET 5 AH1 6 GLU M 46 ILE M 51 -1 O VAL M 48 N TRP M 36 SHEET 6 AH1 6 ILE M 57 TYR M 59 -1 O TYR M 58 N SER M 50 SHEET 1 AH2 4 GLY M 10 VAL M 12 0 SHEET 2 AH2 4 THR M 107 VAL M 111 1 O THR M 110 N GLY M 10 SHEET 3 AH2 4 ALA M 88 LEU M 95 -1 N TYR M 90 O THR M 107 SHEET 4 AH2 4 PHE M 100E TRP M 103 -1 O TYR M 102 N ARG M 94 SHEET 1 AH3 4 SER M 120 LEU M 124 0 SHEET 2 AH3 4 ALA M 136 TYR M 145 -1 O GLY M 139 N LEU M 124 SHEET 3 AH3 4 TYR M 176 VAL M 184 -1 O VAL M 182 N LEU M 138 SHEET 4 AH3 4 VAL M 163 THR M 165 -1 N HIS M 164 O VAL M 181 SHEET 1 AH4 4 SER M 120 LEU M 124 0 SHEET 2 AH4 4 ALA M 136 TYR M 145 -1 O GLY M 139 N LEU M 124 SHEET 3 AH4 4 TYR M 176 VAL M 184 -1 O VAL M 182 N LEU M 138 SHEET 4 AH4 4 VAL M 169 LEU M 170 -1 N VAL M 169 O SER M 177 SHEET 1 AH5 3 THR M 151 TRP M 154 0 SHEET 2 AH5 3 TYR M 194 HIS M 200 -1 O ASN M 199 N THR M 151 SHEET 3 AH5 3 THR M 205 VAL M 211 -1 O VAL M 207 N VAL M 198 SHEET 1 AH6 5 SER N 9 GLY N 13 0 SHEET 2 AH6 5 THR N 102 VAL N 106 1 O LYS N 103 N VAL N 11 SHEET 3 AH6 5 ALA N 84 ASP N 92 -1 N TYR N 86 O THR N 102 SHEET 4 AH6 5 HIS N 34 GLN N 38 -1 N GLN N 38 O ASP N 85 SHEET 5 AH6 5 LYS N 45 ILE N 48 -1 O ILE N 48 N TRP N 35 SHEET 1 AH7 4 SER N 9 GLY N 13 0 SHEET 2 AH7 4 THR N 102 VAL N 106 1 O LYS N 103 N VAL N 11 SHEET 3 AH7 4 ALA N 84 ASP N 92 -1 N TYR N 86 O THR N 102 SHEET 4 AH7 4 PHE N 95C PHE N 98 -1 O PHE N 95C N ASP N 92 SHEET 1 AH8 3 VAL N 19 THR N 24 0 SHEET 2 AH8 3 SER N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 3 AH8 3 PHE N 62 SER N 67 -1 N SER N 63 O ALA N 74 SHEET 1 AH9 4 SER N 114 PHE N 118 0 SHEET 2 AH9 4 ALA N 130 PHE N 139 -1 O SER N 137 N SER N 114 SHEET 3 AH9 4 TYR N 172 LEU N 180 -1 O LEU N 178 N LEU N 132 SHEET 4 AH9 4 VAL N 159 THR N 161 -1 N GLU N 160 O TYR N 177 SHEET 1 AI1 4 SER N 114 PHE N 118 0 SHEET 2 AI1 4 ALA N 130 PHE N 139 -1 O SER N 137 N SER N 114 SHEET 3 AI1 4 TYR N 172 LEU N 180 -1 O LEU N 178 N LEU N 132 SHEET 4 AI1 4 SER N 165 LYS N 166 -1 N SER N 165 O ALA N 173 SHEET 1 AI2 4 SER N 153 VAL N 155 0 SHEET 2 AI2 4 VAL N 144 ALA N 150 -1 N TRP N 148 O VAL N 155 SHEET 3 AI2 4 TYR N 191 HIS N 197 -1 O GLN N 194 N ALA N 147 SHEET 4 AI2 4 SER N 200 VAL N 206 -1 O VAL N 202 N VAL N 195 SHEET 1 AI3 4 LEU O 4 SER O 7 0 SHEET 2 AI3 4 VAL O 19 ALA O 25 -1 O ARG O 24 N THR O 5 SHEET 3 AI3 4 ASP O 70 ILE O 75 -1 O PHE O 71 N CYS O 23 SHEET 4 AI3 4 PHE O 62 GLY O 64 -1 N SER O 63 O THR O 74 SHEET 1 AI4 5 ILE O 10 VAL O 13 0 SHEET 2 AI4 5 THR O 102 ILE O 106 1 O LYS O 103 N LEU O 11 SHEET 3 AI4 5 ASP O 85 GLN O 90 -1 N TYR O 86 O THR O 102 SHEET 4 AI4 5 ILE O 33 GLN O 38 -1 N HIS O 34 O GLN O 89 SHEET 5 AI4 5 ARG O 45 ILE O 48 -1 O ILE O 48 N TRP O 35 SHEET 1 AI5 4 ILE O 10 VAL O 13 0 SHEET 2 AI5 4 THR O 102 ILE O 106 1 O LYS O 103 N LEU O 11 SHEET 3 AI5 4 ASP O 85 GLN O 90 -1 N TYR O 86 O THR O 102 SHEET 4 AI5 4 THR O 97 PHE O 98 -1 O THR O 97 N GLN O 90 SHEET 1 AI6 4 SER O 114 PHE O 118 0 SHEET 2 AI6 4 THR O 129 PHE O 139 -1 O LEU O 135 N PHE O 116 SHEET 3 AI6 4 TYR O 173 SER O 182 -1 O LEU O 181 N ALA O 130 SHEET 4 AI6 4 SER O 159 VAL O 163 -1 N GLN O 160 O THR O 178 SHEET 1 AI7 4 ALA O 153 LEU O 154 0 SHEET 2 AI7 4 ALA O 144 VAL O 150 -1 N VAL O 150 O ALA O 153 SHEET 3 AI7 4 VAL O 191 HIS O 198 -1 O GLU O 195 N GLN O 147 SHEET 4 AI7 4 VAL O 205 ASN O 210 -1 O VAL O 205 N VAL O 196 SHEET 1 AI8 4 GLN P 3 GLN P 6 0 SHEET 2 AI8 4 VAL P 18 THR P 25 -1 O LYS P 23 N GLN P 5 SHEET 3 AI8 4 THR P 77 LEU P 82 -1 O LEU P 82 N VAL P 18 SHEET 4 AI8 4 ALA P 67 ASP P 72 -1 N THR P 70 O TYR P 79 SHEET 1 AI9 6 GLU P 10 MET P 12 0 SHEET 2 AI9 6 THR P 107 VAL P 111 1 O THR P 110 N MET P 12 SHEET 3 AI9 6 ALA P 88 PHE P 97 -1 N TYR P 90 O THR P 107 SHEET 4 AI9 6 TYR P 32 GLN P 39 -1 N TRP P 33 O GLY P 95 SHEET 5 AI9 6 GLU P 46 LEU P 52 -1 O ILE P 48 N TRP P 36 SHEET 6 AI9 6 THR P 57 TYR P 59 -1 O ASN P 58 N GLU P 50 SHEET 1 AJ1 4 GLU P 10 MET P 12 0 SHEET 2 AJ1 4 THR P 107 VAL P 111 1 O THR P 110 N MET P 12 SHEET 3 AJ1 4 ALA P 88 PHE P 97 -1 N TYR P 90 O THR P 107 SHEET 4 AJ1 4 TYR P 102 TRP P 103 -1 O TYR P 102 N ARG P 94 SHEET 1 AJ2 4 SER P 120 LEU P 124 0 SHEET 2 AJ2 4 THR P 135 TYR P 145 -1 O LEU P 141 N PHE P 122 SHEET 3 AJ2 4 TYR P 176 PRO P 185 -1 O LEU P 178 N VAL P 142 SHEET 4 AJ2 4 VAL P 163 THR P 165 -1 N HIS P 164 O VAL P 181 SHEET 1 AJ3 4 SER P 120 LEU P 124 0 SHEET 2 AJ3 4 THR P 135 TYR P 145 -1 O LEU P 141 N PHE P 122 SHEET 3 AJ3 4 TYR P 176 PRO P 185 -1 O LEU P 178 N VAL P 142 SHEET 4 AJ3 4 VAL P 169 LEU P 170 -1 N VAL P 169 O SER P 177 SHEET 1 AJ4 3 THR P 151 TRP P 154 0 SHEET 2 AJ4 3 ILE P 195 HIS P 200 -1 O ASN P 199 N THR P 151 SHEET 3 AJ4 3 THR P 205 ARG P 210 -1 O VAL P 207 N VAL P 198 SHEET 1 AJ5 4 GLN Q 3 SER Q 7 0 SHEET 2 AJ5 4 LEU Q 18 SER Q 25 -1 O SER Q 25 N GLN Q 3 SHEET 3 AJ5 4 SER Q 77 MET Q 82 -1 O MET Q 82 N LEU Q 18 SHEET 4 AJ5 4 PHE Q 67 ASP Q 72 -1 N THR Q 68 O GLN Q 81 SHEET 1 AJ6 6 LEU Q 11 VAL Q 12 0 SHEET 2 AJ6 6 THR Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AJ6 6 ALA Q 88 LEU Q 95 -1 N TYR Q 90 O THR Q 107 SHEET 4 AJ6 6 MET Q 34 GLN Q 39 -1 N VAL Q 37 O TYR Q 91 SHEET 5 AJ6 6 LEU Q 45 ILE Q 51 -1 O VAL Q 48 N TRP Q 36 SHEET 6 AJ6 6 ILE Q 57 TYR Q 59 -1 O TYR Q 58 N SER Q 50 SHEET 1 AJ7 4 LEU Q 11 VAL Q 12 0 SHEET 2 AJ7 4 THR Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AJ7 4 ALA Q 88 LEU Q 95 -1 N TYR Q 90 O THR Q 107 SHEET 4 AJ7 4 PHE Q 100E TRP Q 103 -1 O TYR Q 102 N ARG Q 94 SHEET 1 AJ8 5 SER R 9 GLY R 13 0 SHEET 2 AJ8 5 THR R 102 VAL R 106 1 O LYS R 103 N VAL R 11 SHEET 3 AJ8 5 ALA R 84 ASP R 92 -1 N ALA R 84 O LEU R 104 SHEET 4 AJ8 5 HIS R 34 GLN R 38 -1 N HIS R 34 O GLN R 89 SHEET 5 AJ8 5 LYS R 45 ILE R 48 -1 O ILE R 48 N TRP R 35 SHEET 1 AJ9 4 SER R 9 GLY R 13 0 SHEET 2 AJ9 4 THR R 102 VAL R 106 1 O LYS R 103 N VAL R 11 SHEET 3 AJ9 4 ALA R 84 ASP R 92 -1 N ALA R 84 O LEU R 104 SHEET 4 AJ9 4 PHE R 95C PHE R 98 -1 O VAL R 97 N SER R 90 SHEET 1 AK1 3 VAL R 19 THR R 24 0 SHEET 2 AK1 3 SER R 70 ILE R 75 -1 O ALA R 71 N CYS R 23 SHEET 3 AK1 3 PHE R 62 SER R 67 -1 N SER R 67 O SER R 70 SHEET 1 AK2 4 LEU S 4 SER S 7 0 SHEET 2 AK2 4 VAL S 19 ALA S 25 -1 O ARG S 24 N THR S 5 SHEET 3 AK2 4 ASP S 70 ILE S 75 -1 O PHE S 71 N CYS S 23 SHEET 4 AK2 4 PHE S 62 GLY S 64 -1 N SER S 63 O THR S 74 SHEET 1 AK3 6 ILE S 10 VAL S 13 0 SHEET 2 AK3 6 THR S 102 ILE S 106 1 O GLU S 105 N VAL S 13 SHEET 3 AK3 6 ASP S 85 GLN S 90 -1 N TYR S 86 O THR S 102 SHEET 4 AK3 6 ILE S 33 GLN S 38 -1 N TYR S 36 O TYR S 87 SHEET 5 AK3 6 ARG S 45 LYS S 49 -1 O LEU S 47 N TRP S 35 SHEET 6 AK3 6 GLU S 53 SER S 54 -1 O GLU S 53 N LYS S 49 SHEET 1 AK4 4 SER S 114 PHE S 118 0 SHEET 2 AK4 4 THR S 129 PHE S 139 -1 O LEU S 135 N PHE S 116 SHEET 3 AK4 4 TYR S 173 SER S 182 -1 O LEU S 181 N ALA S 130 SHEET 4 AK4 4 SER S 159 VAL S 163 -1 N GLN S 160 O THR S 178 SHEET 1 AK5 3 ALA S 144 VAL S 150 0 SHEET 2 AK5 3 VAL S 191 HIS S 198 -1 O ALA S 193 N LYS S 149 SHEET 3 AK5 3 VAL S 205 ASN S 210 -1 O VAL S 205 N VAL S 196 SHEET 1 AK6 4 GLN T 3 GLN T 6 0 SHEET 2 AK6 4 VAL T 18 THR T 25 -1 O LYS T 23 N GLN T 5 SHEET 3 AK6 4 THR T 77 LEU T 82 -1 O MET T 80 N LEU T 20 SHEET 4 AK6 4 ALA T 67 ASP T 72 -1 N ASP T 72 O THR T 77 SHEET 1 AK7 6 GLU T 10 MET T 12 0 SHEET 2 AK7 6 THR T 107 VAL T 111 1 O THR T 110 N GLU T 10 SHEET 3 AK7 6 ALA T 88 PHE T 97 -1 N TYR T 90 O THR T 107 SHEET 4 AK7 6 TYR T 32 GLN T 39 -1 N VAL T 37 O TYR T 91 SHEET 5 AK7 6 LEU T 45 GLU T 50 -1 O GLU T 46 N LYS T 38 SHEET 6 AK7 6 ASN T 58 TYR T 59 -1 O ASN T 58 N GLU T 50 SHEET 1 AK8 4 GLU T 10 MET T 12 0 SHEET 2 AK8 4 THR T 107 VAL T 111 1 O THR T 110 N GLU T 10 SHEET 3 AK8 4 ALA T 88 PHE T 97 -1 N TYR T 90 O THR T 107 SHEET 4 AK8 4 TYR T 102 TRP T 103 -1 O TYR T 102 N ARG T 94 SHEET 1 AK9 4 SER T 120 LEU T 124 0 SHEET 2 AK9 4 THR T 135 TYR T 145 -1 O LYS T 143 N SER T 120 SHEET 3 AK9 4 TYR T 176 PRO T 185 -1 O LEU T 178 N VAL T 142 SHEET 4 AK9 4 VAL T 163 THR T 165 -1 N HIS T 164 O VAL T 181 SHEET 1 AL1 4 SER T 120 LEU T 124 0 SHEET 2 AL1 4 THR T 135 TYR T 145 -1 O LYS T 143 N SER T 120 SHEET 3 AL1 4 TYR T 176 PRO T 185 -1 O LEU T 178 N VAL T 142 SHEET 4 AL1 4 VAL T 169 LEU T 170 -1 N VAL T 169 O SER T 177 SHEET 1 AL2 3 THR T 151 TRP T 154 0 SHEET 2 AL2 3 ILE T 195 HIS T 200 -1 O ASN T 197 N SER T 153 SHEET 3 AL2 3 THR T 205 ARG T 210 -1 O VAL T 207 N VAL T 198 SHEET 1 AL3 4 GLN U 3 SER U 7 0 SHEET 2 AL3 4 SER U 17 SER U 25 -1 O ALA U 23 N VAL U 5 SHEET 3 AL3 4 SER U 77 ASN U 82A-1 O LEU U 80 N LEU U 20 SHEET 4 AL3 4 PHE U 67 ASP U 72 -1 N SER U 70 O TYR U 79 SHEET 1 AL4 6 LEU U 11 VAL U 12 0 SHEET 2 AL4 6 THR U 107 VAL U 111 1 O THR U 110 N VAL U 12 SHEET 3 AL4 6 ALA U 88 LEU U 95 -1 N TYR U 90 O THR U 107 SHEET 4 AL4 6 MET U 34 GLN U 39 -1 N VAL U 37 O TYR U 91 SHEET 5 AL4 6 LEU U 45 ILE U 51 -1 O GLU U 46 N ARG U 38 SHEET 6 AL4 6 ILE U 57 TYR U 59 -1 O TYR U 58 N SER U 50 SHEET 1 AL5 4 LEU U 11 VAL U 12 0 SHEET 2 AL5 4 THR U 107 VAL U 111 1 O THR U 110 N VAL U 12 SHEET 3 AL5 4 ALA U 88 LEU U 95 -1 N TYR U 90 O THR U 107 SHEET 4 AL5 4 PHE U 100E TRP U 103 -1 O TYR U 102 N ARG U 94 SHEET 1 AL6 4 SER U 120 PHE U 122 0 SHEET 2 AL6 4 CYS U 140 TYR U 145 -1 O LEU U 141 N PHE U 122 SHEET 3 AL6 4 TYR U 176 SER U 180 -1 O TYR U 176 N TYR U 145 SHEET 4 AL6 4 VAL U 169 LEU U 170 -1 N VAL U 169 O SER U 177 SHEET 1 AL7 2 ASN U 197 VAL U 198 0 SHEET 2 AL7 2 VAL U 207 ASP U 208 -1 O VAL U 207 N VAL U 198 SHEET 1 AL8 5 SER V 9 GLY V 13 0 SHEET 2 AL8 5 THR V 102 VAL V 106 1 O THR V 105 N VAL V 11 SHEET 3 AL8 5 ALA V 84 ASP V 92 -1 N ALA V 84 O LEU V 104 SHEET 4 AL8 5 HIS V 34 GLN V 38 -1 N GLN V 38 O ASP V 85 SHEET 5 AL8 5 LYS V 45 ILE V 48 -1 O ILE V 48 N TRP V 35 SHEET 1 AL9 4 SER V 9 GLY V 13 0 SHEET 2 AL9 4 THR V 102 VAL V 106 1 O THR V 105 N VAL V 11 SHEET 3 AL9 4 ALA V 84 ASP V 92 -1 N ALA V 84 O LEU V 104 SHEET 4 AL9 4 PHE V 95C PHE V 98 -1 O VAL V 97 N SER V 90 SHEET 1 AM1 3 VAL V 19 THR V 24 0 SHEET 2 AM1 3 SER V 70 ILE V 75 -1 O ILE V 75 N VAL V 19 SHEET 3 AM1 3 PHE V 62 SER V 67 -1 N SER V 65 O SER V 72 SHEET 1 AM2 4 SER V 114 PHE V 118 0 SHEET 2 AM2 4 LEU V 132 PHE V 139 -1 O SER V 137 N SER V 114 SHEET 3 AM2 4 TYR V 172 LEU V 178 -1 O TYR V 172 N PHE V 139 SHEET 4 AM2 4 VAL V 159 THR V 161 -1 N GLU V 160 O TYR V 177 SHEET 1 AM3 4 SER V 114 PHE V 118 0 SHEET 2 AM3 4 LEU V 132 PHE V 139 -1 O SER V 137 N SER V 114 SHEET 3 AM3 4 TYR V 172 LEU V 178 -1 O TYR V 172 N PHE V 139 SHEET 4 AM3 4 SER V 165 LYS V 166 -1 N SER V 165 O ALA V 173 SHEET 1 AM4 3 THR V 145 TRP V 148 0 SHEET 2 AM4 3 CYS V 193 HIS V 197 -1 O GLN V 194 N ALA V 147 SHEET 3 AM4 3 SER V 200 LYS V 204 -1 O VAL V 202 N VAL V 195 SHEET 1 AM5 4 LEU W 4 SER W 7 0 SHEET 2 AM5 4 VAL W 19 ALA W 25 -1 O ARG W 24 N THR W 5 SHEET 3 AM5 4 ASP W 70 ILE W 75 -1 O ILE W 75 N VAL W 19 SHEET 4 AM5 4 PHE W 62 GLY W 64 -1 N SER W 63 O THR W 74 SHEET 1 AM6 6 ILE W 10 VAL W 13 0 SHEET 2 AM6 6 THR W 102 ILE W 106 1 O GLU W 105 N VAL W 13 SHEET 3 AM6 6 ASP W 85 GLN W 90 -1 N TYR W 86 O THR W 102 SHEET 4 AM6 6 ILE W 33 GLN W 38 -1 N TYR W 36 O TYR W 87 SHEET 5 AM6 6 ARG W 45 LYS W 49 -1 O ARG W 45 N GLN W 37 SHEET 6 AM6 6 GLU W 53 SER W 54 -1 O GLU W 53 N LYS W 49 SHEET 1 AM7 4 ILE W 10 VAL W 13 0 SHEET 2 AM7 4 THR W 102 ILE W 106 1 O GLU W 105 N VAL W 13 SHEET 3 AM7 4 ASP W 85 GLN W 90 -1 N TYR W 86 O THR W 102 SHEET 4 AM7 4 THR W 97 PHE W 98 -1 O THR W 97 N GLN W 90 SHEET 1 AM8 4 PHE W 116 PHE W 118 0 SHEET 2 AM8 4 THR W 129 PHE W 139 -1 O VAL W 133 N PHE W 118 SHEET 3 AM8 4 TYR W 173 SER W 182 -1 O LEU W 175 N LEU W 136 SHEET 4 AM8 4 SER W 159 VAL W 163 -1 N GLN W 160 O THR W 178 SHEET 1 AM9 3 LYS W 145 GLN W 147 0 SHEET 2 AM9 3 GLU W 195 THR W 197 -1 O THR W 197 N LYS W 145 SHEET 3 AM9 3 VAL W 205 THR W 206 -1 O VAL W 205 N VAL W 196 SHEET 1 AN1 4 GLN X 3 GLN X 6 0 SHEET 2 AN1 4 VAL X 18 THR X 25 -1 O LYS X 23 N GLN X 5 SHEET 3 AN1 4 THR X 77 LEU X 82 -1 O MET X 80 N LEU X 20 SHEET 4 AN1 4 ALA X 67 ASP X 72 -1 N THR X 70 O TYR X 79 SHEET 1 AN2 6 GLU X 10 MET X 12 0 SHEET 2 AN2 6 THR X 107 VAL X 111 1 O THR X 110 N GLU X 10 SHEET 3 AN2 6 ALA X 88 PHE X 97 -1 N ALA X 88 O LEU X 109 SHEET 4 AN2 6 TYR X 32 GLN X 39 -1 N TRP X 33 O GLY X 95 SHEET 5 AN2 6 LEU X 45 LEU X 52 -1 O GLU X 46 N LYS X 38 SHEET 6 AN2 6 THR X 57 TYR X 59 -1 O ASN X 58 N GLU X 50 SHEET 1 AN3 4 SER X 120 LEU X 124 0 SHEET 2 AN3 4 THR X 135 TYR X 145 -1 O LEU X 141 N PHE X 122 SHEET 3 AN3 4 TYR X 176 PRO X 185 -1 O VAL X 184 N ALA X 136 SHEET 4 AN3 4 VAL X 163 THR X 165 -1 N HIS X 164 O VAL X 181 SHEET 1 AN4 4 SER X 120 LEU X 124 0 SHEET 2 AN4 4 THR X 135 TYR X 145 -1 O LEU X 141 N PHE X 122 SHEET 3 AN4 4 TYR X 176 PRO X 185 -1 O VAL X 184 N ALA X 136 SHEET 4 AN4 4 VAL X 169 LEU X 170 -1 N VAL X 169 O SER X 177 SHEET 1 AN5 3 THR X 151 TRP X 154 0 SHEET 2 AN5 3 TYR X 194 HIS X 200 -1 O ASN X 197 N SER X 153 SHEET 3 AN5 3 THR X 205 VAL X 211 -1 O LYS X 209 N CYS X 196 SHEET 1 AN6 4 GLN Y 3 SER Y 7 0 SHEET 2 AN6 4 LEU Y 18 SER Y 25 -1 O ALA Y 23 N VAL Y 5 SHEET 3 AN6 4 SER Y 77 MET Y 82 -1 O MET Y 82 N LEU Y 18 SHEET 4 AN6 4 PHE Y 67 ASP Y 72 -1 N THR Y 68 O GLN Y 81 SHEET 1 AN7 6 GLY Y 10 VAL Y 12 0 SHEET 2 AN7 6 THR Y 107 VAL Y 111 1 O THR Y 110 N GLY Y 10 SHEET 3 AN7 6 ALA Y 88 LEU Y 95 -1 N TYR Y 90 O THR Y 107 SHEET 4 AN7 6 MET Y 34 GLN Y 39 -1 N VAL Y 37 O TYR Y 91 SHEET 5 AN7 6 LEU Y 45 ILE Y 51 -1 O VAL Y 48 N TRP Y 36 SHEET 6 AN7 6 ILE Y 57 TYR Y 59 -1 O TYR Y 58 N SER Y 50 SHEET 1 AN8 4 GLY Y 10 VAL Y 12 0 SHEET 2 AN8 4 THR Y 107 VAL Y 111 1 O THR Y 110 N GLY Y 10 SHEET 3 AN8 4 ALA Y 88 LEU Y 95 -1 N TYR Y 90 O THR Y 107 SHEET 4 AN8 4 PHE Y 100E TRP Y 103 -1 O TYR Y 102 N ARG Y 94 SHEET 1 AN9 5 SER Z 9 VAL Z 11 0 SHEET 2 AN9 5 THR Z 102 LEU Z 104 1 O LYS Z 103 N VAL Z 11 SHEET 3 AN9 5 ASP Z 85 ASP Z 92 -1 N TYR Z 86 O THR Z 102 SHEET 4 AN9 5 HIS Z 34 GLN Z 38 -1 N HIS Z 34 O GLN Z 89 SHEET 5 AN9 5 PRO Z 44 ILE Z 48 -1 O LYS Z 45 N GLN Z 37 SHEET 1 AO1 4 SER Z 9 VAL Z 11 0 SHEET 2 AO1 4 THR Z 102 LEU Z 104 1 O LYS Z 103 N VAL Z 11 SHEET 3 AO1 4 ASP Z 85 ASP Z 92 -1 N TYR Z 86 O THR Z 102 SHEET 4 AO1 4 PHE Z 95C PHE Z 98 -1 O PHE Z 95C N ASP Z 92 SHEET 1 AO2 3 VAL Z 19 THR Z 24 0 SHEET 2 AO2 3 SER Z 70 ILE Z 75 -1 O LEU Z 73 N ILE Z 21 SHEET 3 AO2 3 PHE Z 62 SER Z 67 -1 N SER Z 63 O ALA Z 74 SHEET 1 AO3 4 LEU a 4 SER a 7 0 SHEET 2 AO3 4 VAL a 19 ALA a 25 -1 O ARG a 24 N THR a 5 SHEET 3 AO3 4 ASP a 70 ILE a 75 -1 O ILE a 75 N VAL a 19 SHEET 4 AO3 4 PHE a 62 GLY a 64 -1 N SER a 63 O THR a 74 SHEET 1 AO4 6 ILE a 10 VAL a 13 0 SHEET 2 AO4 6 THR a 102 ILE a 106 1 O GLU a 105 N LEU a 11 SHEET 3 AO4 6 ASP a 85 GLN a 90 -1 N TYR a 86 O THR a 102 SHEET 4 AO4 6 ILE a 33 GLN a 38 -1 N HIS a 34 O GLN a 89 SHEET 5 AO4 6 ARG a 45 LYS a 49 -1 O LEU a 47 N TRP a 35 SHEET 6 AO4 6 GLU a 53 SER a 54 -1 O GLU a 53 N LYS a 49 SHEET 1 AO5 4 ILE a 10 VAL a 13 0 SHEET 2 AO5 4 THR a 102 ILE a 106 1 O GLU a 105 N LEU a 11 SHEET 3 AO5 4 ASP a 85 GLN a 90 -1 N TYR a 86 O THR a 102 SHEET 4 AO5 4 THR a 97 PHE a 98 -1 O THR a 97 N GLN a 90 SHEET 1 AO6 4 SER a 114 PHE a 118 0 SHEET 2 AO6 4 THR a 129 PHE a 139 -1 O LEU a 135 N PHE a 116 SHEET 3 AO6 4 TYR a 173 SER a 182 -1 O LEU a 175 N LEU a 136 SHEET 4 AO6 4 SER a 159 VAL a 163 -1 N SER a 162 O SER a 176 SHEET 1 AO7 4 ALA a 153 LEU a 154 0 SHEET 2 AO7 4 LYS a 145 VAL a 150 -1 N VAL a 150 O ALA a 153 SHEET 3 AO7 4 VAL a 191 THR a 197 -1 O GLU a 195 N GLN a 147 SHEET 4 AO7 4 VAL a 205 ASN a 210 -1 O VAL a 205 N VAL a 196 SHEET 1 AO8 4 GLN b 3 GLN b 6 0 SHEET 2 AO8 4 VAL b 18 THR b 25 -1 O LYS b 23 N GLN b 5 SHEET 3 AO8 4 THR b 77 LEU b 82 -1 O MET b 80 N LEU b 20 SHEET 4 AO8 4 ALA b 67 ASP b 72 -1 N THR b 70 O TYR b 79 SHEET 1 AO9 6 GLU b 10 MET b 12 0 SHEET 2 AO9 6 THR b 107 VAL b 111 1 O THR b 110 N MET b 12 SHEET 3 AO9 6 ALA b 88 PHE b 97 -1 N TYR b 90 O THR b 107 SHEET 4 AO9 6 TYR b 32 GLN b 39 -1 N GLU b 35 O ALA b 93 SHEET 5 AO9 6 GLU b 46 LEU b 52 -1 O ILE b 48 N TRP b 36 SHEET 6 AO9 6 THR b 57 TYR b 59 -1 O ASN b 58 N GLU b 50 SHEET 1 AP1 4 SER b 120 LEU b 124 0 SHEET 2 AP1 4 THR b 135 TYR b 145 -1 O LEU b 141 N PHE b 122 SHEET 3 AP1 4 TYR b 176 PRO b 185 -1 O TYR b 176 N TYR b 145 SHEET 4 AP1 4 VAL b 163 THR b 165 -1 N HIS b 164 O VAL b 181 SHEET 1 AP2 4 SER b 120 LEU b 124 0 SHEET 2 AP2 4 THR b 135 TYR b 145 -1 O LEU b 141 N PHE b 122 SHEET 3 AP2 4 TYR b 176 PRO b 185 -1 O TYR b 176 N TYR b 145 SHEET 4 AP2 4 VAL b 169 LEU b 170 -1 N VAL b 169 O SER b 177 SHEET 1 AP3 3 THR b 151 TRP b 154 0 SHEET 2 AP3 3 ILE b 195 HIS b 200 -1 O ASN b 197 N SER b 153 SHEET 3 AP3 3 THR b 205 ARG b 210 -1 O VAL b 207 N VAL b 198 SHEET 1 AP4 3 GLN c 3 SER c 7 0 SHEET 2 AP4 3 LEU c 20 SER c 25 -1 O SER c 21 N SER c 7 SHEET 3 AP4 3 SER c 77 LEU c 80 -1 O LEU c 78 N CYS c 22 SHEET 1 AP5 2 TRP c 36 ARG c 38 0 SHEET 2 AP5 2 GLU c 46 SER c 49 -1 O GLU c 46 N ARG c 38 SHEET 1 AP6 2 VAL d 19 THR d 24 0 SHEET 2 AP6 2 SER d 70 ILE d 75 -1 O LEU d 73 N ILE d 21 SHEET 1 AP7 2 TYR d 36 GLN d 37 0 SHEET 2 AP7 2 LYS d 45 LEU d 46 -1 O LYS d 45 N GLN d 37 SHEET 1 AP8 2 GLN d 89 SER d 90 0 SHEET 2 AP8 2 VAL d 97 PHE d 98 -1 O VAL d 97 N SER d 90 SHEET 1 AP9 4 LEU e 4 GLN e 6 0 SHEET 2 AP9 4 VAL e 19 ALA e 25 -1 O ARG e 24 N THR e 5 SHEET 3 AP9 4 ASP e 70 ILE e 75 -1 O LEU e 73 N PHE e 21 SHEET 4 AP9 4 PHE e 62 SER e 67 -1 N SER e 63 O THR e 74 SHEET 1 AQ1 5 ILE e 10 VAL e 13 0 SHEET 2 AQ1 5 THR e 102 ILE e 106 1 O GLU e 105 N LEU e 11 SHEET 3 AQ1 5 ASP e 85 GLN e 90 -1 N TYR e 86 O THR e 102 SHEET 4 AQ1 5 ILE e 33 GLN e 38 -1 N HIS e 34 O GLN e 89 SHEET 5 AQ1 5 ARG e 45 LEU e 46 -1 O ARG e 45 N GLN e 37 SHEET 1 AQ2 4 SER e 114 PHE e 118 0 SHEET 2 AQ2 4 THR e 129 PHE e 139 -1 O LEU e 135 N PHE e 116 SHEET 3 AQ2 4 TYR e 173 SER e 182 -1 O LEU e 175 N LEU e 136 SHEET 4 AQ2 4 SER e 159 VAL e 163 -1 N GLN e 160 O THR e 178 SHEET 1 AQ3 4 ALA e 153 LEU e 154 0 SHEET 2 AQ3 4 ALA e 144 VAL e 150 -1 N VAL e 150 O ALA e 153 SHEET 3 AQ3 4 VAL e 191 HIS e 198 -1 O GLU e 195 N GLN e 147 SHEET 4 AQ3 4 VAL e 205 ASN e 210 -1 O VAL e 205 N VAL e 196 SHEET 1 AQ4 4 ILE f 4 GLN f 6 0 SHEET 2 AQ4 4 VAL f 18 ALA f 24 -1 O LYS f 23 N GLN f 5 SHEET 3 AQ4 4 THR f 77 LEU f 82 -1 O MET f 80 N LEU f 20 SHEET 4 AQ4 4 ALA f 67 ALA f 71 -1 N THR f 70 O TYR f 79 SHEET 1 AQ5 6 GLU f 10 MET f 12 0 SHEET 2 AQ5 6 THR f 107 VAL f 111 1 O THR f 110 N MET f 12 SHEET 3 AQ5 6 ALA f 88 PHE f 97 -1 N ALA f 88 O LEU f 109 SHEET 4 AQ5 6 TYR f 32 GLN f 39 -1 N TRP f 33 O GLY f 95 SHEET 5 AQ5 6 GLU f 46 LEU f 52 -1 O GLU f 46 N LYS f 38 SHEET 6 AQ5 6 THR f 57 TYR f 59 -1 O ASN f 58 N GLU f 50 SHEET 1 AQ6 4 SER f 120 LEU f 124 0 SHEET 2 AQ6 4 THR f 135 TYR f 145 -1 O LEU f 141 N PHE f 122 SHEET 3 AQ6 4 TYR f 176 PRO f 185 -1 O VAL f 184 N ALA f 136 SHEET 4 AQ6 4 VAL f 163 THR f 165 -1 N HIS f 164 O VAL f 181 SHEET 1 AQ7 4 SER f 120 LEU f 124 0 SHEET 2 AQ7 4 THR f 135 TYR f 145 -1 O LEU f 141 N PHE f 122 SHEET 3 AQ7 4 TYR f 176 PRO f 185 -1 O VAL f 184 N ALA f 136 SHEET 4 AQ7 4 VAL f 169 LEU f 170 -1 N VAL f 169 O SER f 177 SHEET 1 AQ8 3 THR f 151 TRP f 154 0 SHEET 2 AQ8 3 TYR f 194 HIS f 200 -1 O ASN f 197 N SER f 153 SHEET 3 AQ8 3 THR f 205 VAL f 211 -1 O THR f 205 N HIS f 200 SSBOND 1 CYS A 22 CYS A 92 1555 1555 2.03 SSBOND 2 CYS A 98 CYS A 100C 1555 1555 2.03 SSBOND 3 CYS A 140 CYS A 196 1555 1555 2.03 SSBOND 4 CYS B 23 CYS B 88 1555 1555 2.04 SSBOND 5 CYS B 134 CYS B 193 1555 1555 2.04 SSBOND 6 CYS C 23 CYS C 88 1555 1555 2.04 SSBOND 7 CYS C 134 CYS C 194 1555 1555 2.03 SSBOND 8 CYS D 22 CYS D 92 1555 1555 2.03 SSBOND 9 CYS D 140 CYS D 196 1555 1555 2.03 SSBOND 10 CYS E 22 CYS E 92 1555 1555 2.04 SSBOND 11 CYS E 98 CYS E 100C 1555 1555 2.03 SSBOND 12 CYS E 140 CYS E 196 1555 1555 2.03 SSBOND 13 CYS F 23 CYS F 88 1555 1555 2.03 SSBOND 14 CYS F 134 CYS F 193 1555 1555 2.03 SSBOND 15 CYS G 23 CYS G 88 1555 1555 2.04 SSBOND 16 CYS G 134 CYS G 194 1555 1555 2.04 SSBOND 17 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 18 CYS H 140 CYS H 196 1555 1555 2.03 SSBOND 19 CYS I 22 CYS I 92 1555 1555 2.03 SSBOND 20 CYS I 98 CYS I 100C 1555 1555 2.03 SSBOND 21 CYS J 23 CYS J 88 1555 1555 2.03 SSBOND 22 CYS K 23 CYS K 88 1555 1555 2.04 SSBOND 23 CYS K 134 CYS K 194 1555 1555 2.04 SSBOND 24 CYS L 22 CYS L 92 1555 1555 2.03 SSBOND 25 CYS L 140 CYS L 196 1555 1555 2.03 SSBOND 26 CYS M 22 CYS M 92 1555 1555 2.03 SSBOND 27 CYS M 98 CYS M 100C 1555 1555 2.04 SSBOND 28 CYS M 140 CYS M 196 1555 1555 2.03 SSBOND 29 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 30 CYS N 134 CYS N 193 1555 1555 2.03 SSBOND 31 CYS O 23 CYS O 88 1555 1555 2.04 SSBOND 32 CYS O 134 CYS O 194 1555 1555 2.04 SSBOND 33 CYS P 22 CYS P 92 1555 1555 2.03 SSBOND 34 CYS P 140 CYS P 196 1555 1555 2.03 SSBOND 35 CYS Q 22 CYS Q 92 1555 1555 2.03 SSBOND 36 CYS Q 98 CYS Q 100C 1555 1555 2.03 SSBOND 37 CYS R 23 CYS R 88 1555 1555 2.03 SSBOND 38 CYS S 23 CYS S 88 1555 1555 2.03 SSBOND 39 CYS S 134 CYS S 194 1555 1555 2.04 SSBOND 40 CYS T 22 CYS T 92 1555 1555 2.03 SSBOND 41 CYS T 140 CYS T 196 1555 1555 2.03 SSBOND 42 CYS U 22 CYS U 92 1555 1555 2.03 SSBOND 43 CYS U 98 CYS U 100C 1555 1555 2.03 SSBOND 44 CYS U 140 CYS U 196 1555 1555 2.03 SSBOND 45 CYS V 23 CYS V 88 1555 1555 2.03 SSBOND 46 CYS V 134 CYS V 193 1555 1555 2.03 SSBOND 47 CYS W 23 CYS W 88 1555 1555 2.04 SSBOND 48 CYS W 134 CYS W 194 1555 1555 2.03 SSBOND 49 CYS X 22 CYS X 92 1555 1555 2.03 SSBOND 50 CYS X 140 CYS X 196 1555 1555 2.03 SSBOND 51 CYS Y 22 CYS Y 92 1555 1555 2.03 SSBOND 52 CYS Y 98 CYS Y 100C 1555 1555 2.04 SSBOND 53 CYS Z 23 CYS Z 88 1555 1555 2.03 SSBOND 54 CYS a 23 CYS a 88 1555 1555 2.04 SSBOND 55 CYS a 134 CYS a 194 1555 1555 2.04 SSBOND 56 CYS b 22 CYS b 92 1555 1555 2.03 SSBOND 57 CYS b 140 CYS b 196 1555 1555 2.03 SSBOND 58 CYS c 22 CYS c 92 1555 1555 2.03 SSBOND 59 CYS c 98 CYS c 100C 1555 1555 2.03 SSBOND 60 CYS d 23 CYS d 88 1555 1555 2.03 SSBOND 61 CYS e 23 CYS e 88 1555 1555 2.03 SSBOND 62 CYS e 134 CYS e 194 1555 1555 2.03 SSBOND 63 CYS f 22 CYS f 92 1555 1555 2.03 SSBOND 64 CYS f 140 CYS f 196 1555 1555 2.03 LINK C PCA D 1 N VAL D 2 1555 1555 1.33 LINK C PCA F 1 N PRO F 2 1555 1555 1.35 LINK C PCA H 1 N VAL H 2 1555 1555 1.33 LINK C PCA L 1 N VAL L 2 1555 1555 1.33 LINK C PCA N 1 N PRO N 2 1555 1555 1.35 LINK C PCA P 1 N VAL P 2 1555 1555 1.33 LINK C PCA T 1 N VAL T 2 1555 1555 1.33 LINK C PCA V 1 N PRO V 2 1555 1555 1.36 LINK C PCA X 1 N VAL X 2 1555 1555 1.33 LINK C PCA b 1 N VAL b 2 1555 1555 1.33 CISPEP 1 PHE A 146 PRO A 147 0 -5.62 CISPEP 2 GLU A 148 PRO A 149 0 1.16 CISPEP 3 TYR B 140 PRO B 141 0 1.76 CISPEP 4 TRP C 94 PRO C 95 0 -2.02 CISPEP 5 TYR C 140 PRO C 141 0 1.31 CISPEP 6 PHE D 146 PRO D 147 0 -7.85 CISPEP 7 GLU D 148 PRO D 149 0 -4.72 CISPEP 8 PHE E 146 PRO E 147 0 -3.82 CISPEP 9 GLU E 148 PRO E 149 0 -2.61 CISPEP 10 TYR F 140 PRO F 141 0 -1.56 CISPEP 11 SER G 7 PRO G 8 0 -4.23 CISPEP 12 TRP G 94 PRO G 95 0 -2.00 CISPEP 13 TYR G 140 PRO G 141 0 1.74 CISPEP 14 PHE H 146 PRO H 147 0 -5.62 CISPEP 15 GLU H 148 PRO H 149 0 0.22 CISPEP 16 SER K 7 PRO K 8 0 -3.30 CISPEP 17 TRP K 94 PRO K 95 0 -2.51 CISPEP 18 TYR K 140 PRO K 141 0 1.26 CISPEP 19 PHE L 146 PRO L 147 0 -3.84 CISPEP 20 GLU L 148 PRO L 149 0 -0.77 CISPEP 21 PHE M 146 PRO M 147 0 -3.59 CISPEP 22 GLU M 148 PRO M 149 0 2.03 CISPEP 23 TYR N 140 PRO N 141 0 4.70 CISPEP 24 SER O 7 PRO O 8 0 -4.08 CISPEP 25 TRP O 94 PRO O 95 0 -1.13 CISPEP 26 TYR O 140 PRO O 141 0 0.65 CISPEP 27 PHE P 146 PRO P 147 0 -6.12 CISPEP 28 GLU P 148 PRO P 149 0 1.04 CISPEP 29 SER S 7 PRO S 8 0 3.51 CISPEP 30 TRP S 94 PRO S 95 0 2.94 CISPEP 31 TYR S 140 PRO S 141 0 0.35 CISPEP 32 PHE T 146 PRO T 147 0 -2.56 CISPEP 33 GLU T 148 PRO T 149 0 -3.10 CISPEP 34 PHE U 146 PRO U 147 0 -5.60 CISPEP 35 GLU U 148 PRO U 149 0 -1.68 CISPEP 36 TYR V 140 PRO V 141 0 2.74 CISPEP 37 SER W 7 PRO W 8 0 -6.64 CISPEP 38 TRP W 94 PRO W 95 0 0.99 CISPEP 39 TYR W 140 PRO W 141 0 4.34 CISPEP 40 PHE X 146 PRO X 147 0 -7.38 CISPEP 41 GLU X 148 PRO X 149 0 -1.57 CISPEP 42 SER a 7 PRO a 8 0 -2.47 CISPEP 43 TRP a 94 PRO a 95 0 -2.31 CISPEP 44 TYR a 140 PRO a 141 0 1.33 CISPEP 45 PHE b 146 PRO b 147 0 -3.24 CISPEP 46 GLU b 148 PRO b 149 0 -0.03 CISPEP 47 SER e 7 PRO e 8 0 -1.56 CISPEP 48 TRP e 94 PRO e 95 0 1.47 CISPEP 49 TYR e 140 PRO e 141 0 2.57 CISPEP 50 PHE f 146 PRO f 147 0 -2.68 CISPEP 51 GLU f 148 PRO f 149 0 -1.36 CRYST1 95.069 149.981 164.430 83.98 89.90 74.61 P 1 8 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.010519 -0.002895 0.000297 0.00000 SCALE2 0.000000 0.006915 -0.000754 0.00000 SCALE3 0.000000 0.000000 0.006118 0.00000