HEADER VIRAL PROTEIN/IMMUNE SYSTEM 11-DEC-23 8XEA TITLE XBB.1.5 SPIKE PROTEIN IN COMPLEX WITH BD55-1205 COMPND MOL_ID: 1; COMPND 2 MOLECULE: BD55-1205 HEAVY CHAIN; COMPND 3 CHAIN: A, G, H; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: BD55-1205 LIGHT CHAIN; COMPND 7 CHAIN: B, I, J; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 11 CHAIN: D, E, F; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 15 2; SOURCE 16 ORGANISM_TAXID: 2697049; SOURCE 17 VARIANT: XBB.1.5; SOURCE 18 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 20 EXPRESSION_SYSTEM_CELL_LINE: HEK293 KEYWDS SARS-COV-2, XBB.1.5, SPIKE PROTEIN, ANTIBODY, BD55-1205, VIRAL KEYWDS 2 PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR L.L.FENG JRNL AUTH L.L.FENG JRNL TITL XBB.1.5 SPIKE PROTEIN IN COMPLEX WITH BD55-1205 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.42 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.420 REMARK 3 NUMBER OF PARTICLES : 238788 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8XEA COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ. REMARK 100 THE DEPOSITION ID IS D_1300043240. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : XBB.1.5 SPIKE PROTEIN IN REMARK 245 COMPLEX WITH BD55-1205; SPIKE REMARK 245 PROTEIN; BD55-1205 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TALOS ARCTICA REMARK 245 DETECTOR TYPE : GATAN K2 QUANTUM (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1200.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1800.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : DARK FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 52.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, D, E, F, G, I, H, J REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET D 1 REMARK 465 PHE D 2 REMARK 465 VAL D 3 REMARK 465 PHE D 4 REMARK 465 LEU D 5 REMARK 465 VAL D 6 REMARK 465 LEU D 7 REMARK 465 LEU D 8 REMARK 465 PRO D 9 REMARK 465 LEU D 10 REMARK 465 VAL D 11 REMARK 465 SER D 12 REMARK 465 SER D 13 REMARK 465 GLN D 23 REMARK 465 LEU D 24 REMARK 465 PRO D 25 REMARK 465 VAL D 70 REMARK 465 SER D 71 REMARK 465 GLY D 72 REMARK 465 THR D 73 REMARK 465 ASN D 74 REMARK 465 GLY D 75 REMARK 465 THR D 76 REMARK 465 TYR D 144 REMARK 465 GLU D 619 REMARK 465 VAL D 620 REMARK 465 PRO D 621 REMARK 465 VAL D 622 REMARK 465 ALA D 623 REMARK 465 ILE D 624 REMARK 465 HIS D 625 REMARK 465 ALA D 626 REMARK 465 ASP D 627 REMARK 465 GLN D 628 REMARK 465 LEU D 629 REMARK 465 THR D 630 REMARK 465 PRO D 631 REMARK 465 THR D 632 REMARK 465 THR D 676 REMARK 465 GLN D 677 REMARK 465 THR D 678 REMARK 465 ASN D 679 REMARK 465 SER D 680 REMARK 465 PRO D 681 REMARK 465 ARG D 682 REMARK 465 ARG D 683 REMARK 465 ALA D 684 REMARK 465 ARG D 685 REMARK 465 SER D 686 REMARK 465 VAL D 687 REMARK 465 ALA D 688 REMARK 465 SER D 689 REMARK 465 THR D 827 REMARK 465 LEU D 828 REMARK 465 ALA D 829 REMARK 465 ASP D 830 REMARK 465 ALA D 831 REMARK 465 GLY D 832 REMARK 465 PHE D 833 REMARK 465 ILE D 834 REMARK 465 LYS D 835 REMARK 465 GLN D 836 REMARK 465 TYR D 837 REMARK 465 GLY D 838 REMARK 465 ASP D 839 REMARK 465 CYS D 840 REMARK 465 LEU D 841 REMARK 465 GLY D 842 REMARK 465 ASP D 843 REMARK 465 ILE D 844 REMARK 465 ALA D 845 REMARK 465 ALA D 846 REMARK 465 ARG D 847 REMARK 465 ASP D 848 REMARK 465 GLY D 1141 REMARK 465 GLY D 1142 REMARK 465 SER D 1143 REMARK 465 GLY D 1144 REMARK 465 GLY D 1145 REMARK 465 SER D 1146 REMARK 465 TYR D 1147 REMARK 465 ILE D 1148 REMARK 465 PRO D 1149 REMARK 465 GLU D 1150 REMARK 465 ALA D 1151 REMARK 465 PRO D 1152 REMARK 465 ARG D 1153 REMARK 465 ASP D 1154 REMARK 465 GLY D 1155 REMARK 465 GLN D 1156 REMARK 465 ALA D 1157 REMARK 465 TYR D 1158 REMARK 465 VAL D 1159 REMARK 465 ARG D 1160 REMARK 465 LYS D 1161 REMARK 465 ASP D 1162 REMARK 465 GLY D 1163 REMARK 465 GLU D 1164 REMARK 465 TRP D 1165 REMARK 465 VAL D 1166 REMARK 465 LEU D 1167 REMARK 465 LEU D 1168 REMARK 465 SER D 1169 REMARK 465 THR D 1170 REMARK 465 PHE D 1171 REMARK 465 LEU D 1172 REMARK 465 GLY D 1173 REMARK 465 ARG D 1174 REMARK 465 SER D 1175 REMARK 465 LEU D 1176 REMARK 465 GLU D 1177 REMARK 465 VAL D 1178 REMARK 465 LEU D 1179 REMARK 465 PHE D 1180 REMARK 465 GLN D 1181 REMARK 465 GLY D 1182 REMARK 465 PRO D 1183 REMARK 465 GLY D 1184 REMARK 465 TRP D 1185 REMARK 465 SER D 1186 REMARK 465 HIS D 1187 REMARK 465 PRO D 1188 REMARK 465 GLN D 1189 REMARK 465 PHE D 1190 REMARK 465 GLU D 1191 REMARK 465 LYS D 1192 REMARK 465 GLY D 1193 REMARK 465 GLY D 1194 REMARK 465 GLY D 1195 REMARK 465 SER D 1196 REMARK 465 GLY D 1197 REMARK 465 GLY D 1198 REMARK 465 GLY D 1199 REMARK 465 SER D 1200 REMARK 465 GLY D 1201 REMARK 465 GLY D 1202 REMARK 465 SER D 1203 REMARK 465 SER D 1204 REMARK 465 ALA D 1205 REMARK 465 TRP D 1206 REMARK 465 SER D 1207 REMARK 465 HIS D 1208 REMARK 465 PRO D 1209 REMARK 465 GLN D 1210 REMARK 465 PHE D 1211 REMARK 465 GLU D 1212 REMARK 465 LYS D 1213 REMARK 465 HIS D 1214 REMARK 465 HIS D 1215 REMARK 465 HIS D 1216 REMARK 465 HIS D 1217 REMARK 465 HIS D 1218 REMARK 465 HIS D 1219 REMARK 465 HIS D 1220 REMARK 465 HIS D 1221 REMARK 465 MET E 1 REMARK 465 PHE E 2 REMARK 465 VAL E 3 REMARK 465 PHE E 4 REMARK 465 LEU E 5 REMARK 465 VAL E 6 REMARK 465 LEU E 7 REMARK 465 LEU E 8 REMARK 465 PRO E 9 REMARK 465 LEU E 10 REMARK 465 VAL E 11 REMARK 465 SER E 12 REMARK 465 SER E 13 REMARK 465 GLN E 23 REMARK 465 LEU E 24 REMARK 465 PRO E 25 REMARK 465 VAL E 70 REMARK 465 SER E 71 REMARK 465 GLY E 72 REMARK 465 THR E 73 REMARK 465 ASN E 74 REMARK 465 GLY E 75 REMARK 465 THR E 76 REMARK 465 TYR E 144 REMARK 465 GLU E 619 REMARK 465 VAL E 620 REMARK 465 PRO E 621 REMARK 465 VAL E 622 REMARK 465 ALA E 623 REMARK 465 ILE E 624 REMARK 465 HIS E 625 REMARK 465 ALA E 626 REMARK 465 ASP E 627 REMARK 465 GLN E 628 REMARK 465 LEU E 629 REMARK 465 THR E 630 REMARK 465 PRO E 631 REMARK 465 THR E 632 REMARK 465 THR E 676 REMARK 465 GLN E 677 REMARK 465 THR E 678 REMARK 465 ASN E 679 REMARK 465 SER E 680 REMARK 465 PRO E 681 REMARK 465 ARG E 682 REMARK 465 ARG E 683 REMARK 465 ALA E 684 REMARK 465 ARG E 685 REMARK 465 SER E 686 REMARK 465 VAL E 687 REMARK 465 ALA E 688 REMARK 465 SER E 689 REMARK 465 LEU E 828 REMARK 465 ALA E 829 REMARK 465 ASP E 830 REMARK 465 ALA E 831 REMARK 465 GLY E 832 REMARK 465 PHE E 833 REMARK 465 ILE E 834 REMARK 465 LYS E 835 REMARK 465 GLN E 836 REMARK 465 TYR E 837 REMARK 465 GLY E 838 REMARK 465 ASP E 839 REMARK 465 CYS E 840 REMARK 465 LEU E 841 REMARK 465 GLY E 842 REMARK 465 ASP E 843 REMARK 465 ILE E 844 REMARK 465 ALA E 845 REMARK 465 ALA E 846 REMARK 465 ARG E 847 REMARK 465 ASP E 848 REMARK 465 LEU E 849 REMARK 465 GLY E 1141 REMARK 465 GLY E 1142 REMARK 465 SER E 1143 REMARK 465 GLY E 1144 REMARK 465 GLY E 1145 REMARK 465 SER E 1146 REMARK 465 TYR E 1147 REMARK 465 ILE E 1148 REMARK 465 PRO E 1149 REMARK 465 GLU E 1150 REMARK 465 ALA E 1151 REMARK 465 PRO E 1152 REMARK 465 ARG E 1153 REMARK 465 ASP E 1154 REMARK 465 GLY E 1155 REMARK 465 GLN E 1156 REMARK 465 ALA E 1157 REMARK 465 TYR E 1158 REMARK 465 VAL E 1159 REMARK 465 ARG E 1160 REMARK 465 LYS E 1161 REMARK 465 ASP E 1162 REMARK 465 GLY E 1163 REMARK 465 GLU E 1164 REMARK 465 TRP E 1165 REMARK 465 VAL E 1166 REMARK 465 LEU E 1167 REMARK 465 LEU E 1168 REMARK 465 SER E 1169 REMARK 465 THR E 1170 REMARK 465 PHE E 1171 REMARK 465 LEU E 1172 REMARK 465 GLY E 1173 REMARK 465 ARG E 1174 REMARK 465 SER E 1175 REMARK 465 LEU E 1176 REMARK 465 GLU E 1177 REMARK 465 VAL E 1178 REMARK 465 LEU E 1179 REMARK 465 PHE E 1180 REMARK 465 GLN E 1181 REMARK 465 GLY E 1182 REMARK 465 PRO E 1183 REMARK 465 GLY E 1184 REMARK 465 TRP E 1185 REMARK 465 SER E 1186 REMARK 465 HIS E 1187 REMARK 465 PRO E 1188 REMARK 465 GLN E 1189 REMARK 465 PHE E 1190 REMARK 465 GLU E 1191 REMARK 465 LYS E 1192 REMARK 465 GLY E 1193 REMARK 465 GLY E 1194 REMARK 465 GLY E 1195 REMARK 465 SER E 1196 REMARK 465 GLY E 1197 REMARK 465 GLY E 1198 REMARK 465 GLY E 1199 REMARK 465 SER E 1200 REMARK 465 GLY E 1201 REMARK 465 GLY E 1202 REMARK 465 SER E 1203 REMARK 465 SER E 1204 REMARK 465 ALA E 1205 REMARK 465 TRP E 1206 REMARK 465 SER E 1207 REMARK 465 HIS E 1208 REMARK 465 PRO E 1209 REMARK 465 GLN E 1210 REMARK 465 PHE E 1211 REMARK 465 GLU E 1212 REMARK 465 LYS E 1213 REMARK 465 HIS E 1214 REMARK 465 HIS E 1215 REMARK 465 HIS E 1216 REMARK 465 HIS E 1217 REMARK 465 HIS E 1218 REMARK 465 HIS E 1219 REMARK 465 HIS E 1220 REMARK 465 HIS E 1221 REMARK 465 MET F 1 REMARK 465 PHE F 2 REMARK 465 VAL F 3 REMARK 465 PHE F 4 REMARK 465 LEU F 5 REMARK 465 VAL F 6 REMARK 465 LEU F 7 REMARK 465 LEU F 8 REMARK 465 PRO F 9 REMARK 465 LEU F 10 REMARK 465 VAL F 11 REMARK 465 SER F 12 REMARK 465 SER F 13 REMARK 465 GLN F 23 REMARK 465 LEU F 24 REMARK 465 PRO F 25 REMARK 465 VAL F 70 REMARK 465 SER F 71 REMARK 465 GLY F 72 REMARK 465 THR F 73 REMARK 465 ASN F 74 REMARK 465 GLY F 75 REMARK 465 THR F 76 REMARK 465 TYR F 144 REMARK 465 GLU F 619 REMARK 465 VAL F 620 REMARK 465 PRO F 621 REMARK 465 VAL F 622 REMARK 465 ALA F 623 REMARK 465 ILE F 624 REMARK 465 HIS F 625 REMARK 465 ALA F 626 REMARK 465 ASP F 627 REMARK 465 GLN F 628 REMARK 465 LEU F 629 REMARK 465 THR F 630 REMARK 465 PRO F 631 REMARK 465 THR F 632 REMARK 465 THR F 676 REMARK 465 GLN F 677 REMARK 465 THR F 678 REMARK 465 ASN F 679 REMARK 465 SER F 680 REMARK 465 PRO F 681 REMARK 465 ARG F 682 REMARK 465 ARG F 683 REMARK 465 ALA F 684 REMARK 465 ARG F 685 REMARK 465 SER F 686 REMARK 465 VAL F 687 REMARK 465 ALA F 688 REMARK 465 SER F 689 REMARK 465 LEU F 828 REMARK 465 ALA F 829 REMARK 465 ASP F 830 REMARK 465 ALA F 831 REMARK 465 GLY F 832 REMARK 465 PHE F 833 REMARK 465 ILE F 834 REMARK 465 LYS F 835 REMARK 465 GLN F 836 REMARK 465 TYR F 837 REMARK 465 GLY F 838 REMARK 465 ASP F 839 REMARK 465 CYS F 840 REMARK 465 LEU F 841 REMARK 465 GLY F 842 REMARK 465 ASP F 843 REMARK 465 ILE F 844 REMARK 465 ALA F 845 REMARK 465 ALA F 846 REMARK 465 ARG F 847 REMARK 465 ASP F 848 REMARK 465 GLY F 1141 REMARK 465 GLY F 1142 REMARK 465 SER F 1143 REMARK 465 GLY F 1144 REMARK 465 GLY F 1145 REMARK 465 SER F 1146 REMARK 465 TYR F 1147 REMARK 465 ILE F 1148 REMARK 465 PRO F 1149 REMARK 465 GLU F 1150 REMARK 465 ALA F 1151 REMARK 465 PRO F 1152 REMARK 465 ARG F 1153 REMARK 465 ASP F 1154 REMARK 465 GLY F 1155 REMARK 465 GLN F 1156 REMARK 465 ALA F 1157 REMARK 465 TYR F 1158 REMARK 465 VAL F 1159 REMARK 465 ARG F 1160 REMARK 465 LYS F 1161 REMARK 465 ASP F 1162 REMARK 465 GLY F 1163 REMARK 465 GLU F 1164 REMARK 465 TRP F 1165 REMARK 465 VAL F 1166 REMARK 465 LEU F 1167 REMARK 465 LEU F 1168 REMARK 465 SER F 1169 REMARK 465 THR F 1170 REMARK 465 PHE F 1171 REMARK 465 LEU F 1172 REMARK 465 GLY F 1173 REMARK 465 ARG F 1174 REMARK 465 SER F 1175 REMARK 465 LEU F 1176 REMARK 465 GLU F 1177 REMARK 465 VAL F 1178 REMARK 465 LEU F 1179 REMARK 465 PHE F 1180 REMARK 465 GLN F 1181 REMARK 465 GLY F 1182 REMARK 465 PRO F 1183 REMARK 465 GLY F 1184 REMARK 465 TRP F 1185 REMARK 465 SER F 1186 REMARK 465 HIS F 1187 REMARK 465 PRO F 1188 REMARK 465 GLN F 1189 REMARK 465 PHE F 1190 REMARK 465 GLU F 1191 REMARK 465 LYS F 1192 REMARK 465 GLY F 1193 REMARK 465 GLY F 1194 REMARK 465 GLY F 1195 REMARK 465 SER F 1196 REMARK 465 GLY F 1197 REMARK 465 GLY F 1198 REMARK 465 GLY F 1199 REMARK 465 SER F 1200 REMARK 465 GLY F 1201 REMARK 465 GLY F 1202 REMARK 465 SER F 1203 REMARK 465 SER F 1204 REMARK 465 ALA F 1205 REMARK 465 TRP F 1206 REMARK 465 SER F 1207 REMARK 465 HIS F 1208 REMARK 465 PRO F 1209 REMARK 465 GLN F 1210 REMARK 465 PHE F 1211 REMARK 465 GLU F 1212 REMARK 465 LYS F 1213 REMARK 465 HIS F 1214 REMARK 465 HIS F 1215 REMARK 465 HIS F 1216 REMARK 465 HIS F 1217 REMARK 465 HIS F 1218 REMARK 465 HIS F 1219 REMARK 465 HIS F 1220 REMARK 465 HIS F 1221 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 ASP D 40 CB - CG - OD2 ANGL. DEV. = 6.0 DEGREES REMARK 500 ASP D 985 CB - CG - OD1 ANGL. DEV. = 6.1 DEGREES REMARK 500 ASP E 985 CB - CG - OD1 ANGL. DEV. = 6.2 DEGREES REMARK 500 ASP F 40 CB - CG - OD2 ANGL. DEV. = 7.2 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PHE A 27 -168.60 -160.37 REMARK 500 SER B 52 -3.87 -141.64 REMARK 500 TYR B 91 48.95 -93.11 REMARK 500 ASP D 88 58.35 39.42 REMARK 500 SER D 98 -8.48 71.95 REMARK 500 THR D 108 -60.94 -95.18 REMARK 500 ASP D 142 -81.13 171.66 REMARK 500 ASN D 148 158.28 62.65 REMARK 500 ASN D 149 -5.45 67.21 REMARK 500 MET D 153 72.92 -100.36 REMARK 500 TYR D 160 -40.48 -131.21 REMARK 500 ALA D 163 65.00 60.04 REMARK 500 ASP D 215 -143.06 47.95 REMARK 500 LEU D 244 101.48 -161.67 REMARK 500 ARG D 246 -141.99 33.28 REMARK 500 SER D 247 58.13 -99.28 REMARK 500 TYR D 248 -128.05 49.24 REMARK 500 ASN D 282 23.57 -140.24 REMARK 500 ILE D 332 136.02 66.51 REMARK 500 ALA D 372 147.06 67.65 REMARK 500 PHE D 377 35.56 -99.20 REMARK 500 ASP D 428 30.15 -95.74 REMARK 500 PRO D 499 44.36 -80.92 REMARK 500 ARG D 634 48.68 39.34 REMARK 500 TYR D 636 -67.54 64.22 REMARK 500 ASN D 710 33.46 -141.66 REMARK 500 TYR D 796 52.47 -97.39 REMARK 500 PHE D 797 48.81 -91.28 REMARK 500 ASP D 994 -34.88 -130.00 REMARK 500 ASP D1041 -5.27 72.45 REMARK 500 ALA E 67 49.20 -83.18 REMARK 500 SER E 98 -3.65 68.16 REMARK 500 ARG E 102 -40.36 -130.39 REMARK 500 GLN E 146 -65.81 -92.22 REMARK 500 LYS E 150 -4.85 69.20 REMARK 500 SER E 161 -0.79 63.28 REMARK 500 ASN E 164 32.96 -97.78 REMARK 500 ASP E 215 -141.46 49.38 REMARK 500 ILE E 231 -51.04 -127.85 REMARK 500 LEU E 244 178.64 61.76 REMARK 500 THR E 250 -39.47 -39.51 REMARK 500 SER E 255 89.67 -150.04 REMARK 500 SER E 256 87.82 -152.61 REMARK 500 PRO E 337 48.73 -82.95 REMARK 500 SER E 366 -38.95 -130.48 REMARK 500 ALA E 372 145.63 67.93 REMARK 500 ASP E 428 30.36 -97.22 REMARK 500 SER E 530 66.52 63.04 REMARK 500 PHE E 559 179.04 60.54 REMARK 500 LEU E 582 73.26 -102.76 REMARK 500 REMARK 500 THIS ENTRY HAS 88 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 GLY D 261 ALA D 262 -149.34 REMARK 500 GLY F 261 ALA F 262 -148.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-38284 RELATED DB: EMDB REMARK 900 XBB.1.5 SPIKE PROTEIN IN COMPLEX WITH BD55-1205 DBREF 8XEA A 1 117 PDB 8XEA 8XEA 1 117 DBREF 8XEA B 1 107 PDB 8XEA 8XEA 1 107 DBREF 8XEA D 1 1140 UNP P0DTC2 SPIKE_SARS2 1 1140 DBREF 8XEA E 1 1140 UNP P0DTC2 SPIKE_SARS2 1 1140 DBREF 8XEA F 1 1140 UNP P0DTC2 SPIKE_SARS2 1 1140 DBREF 8XEA G 1 117 PDB 8XEA 8XEA 1 117 DBREF 8XEA I 1 107 PDB 8XEA 8XEA 1 107 DBREF 8XEA H 1 117 PDB 8XEA 8XEA 1 117 DBREF 8XEA J 1 107 PDB 8XEA 8XEA 1 107 SEQADV 8XEA ILE D 19 UNP P0DTC2 THR 19 VARIANT SEQADV 8XEA GLN D 26 UNP P0DTC2 PRO 26 VARIANT SEQADV 8XEA SER D 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 8XEA ALA D 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 8XEA ASP D 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 8XEA GLN D 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 8XEA GLU D 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 8XEA GLU D 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 8XEA VAL D 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 8XEA HIS D 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 8XEA THR D 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 8XEA ILE D 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 8XEA PHE D 371 UNP P0DTC2 SER 371 VARIANT SEQADV 8XEA PRO D 373 UNP P0DTC2 SER 373 VARIANT SEQADV 8XEA PHE D 375 UNP P0DTC2 SER 375 VARIANT SEQADV 8XEA ALA D 376 UNP P0DTC2 THR 376 VARIANT SEQADV 8XEA ASN D 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 8XEA SER D 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 8XEA ASN D 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 8XEA LYS D 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 8XEA PRO D 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 8XEA SER D 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 8XEA LYS D 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 8XEA ASN D 477 UNP P0DTC2 SER 477 VARIANT SEQADV 8XEA LYS D 478 UNP P0DTC2 THR 478 VARIANT SEQADV 8XEA ALA D 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 8XEA PRO D 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 8XEA SER D 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 8XEA ARG D 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 8XEA TYR D 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 8XEA HIS D 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 8XEA GLY D 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 8XEA TYR D 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 8XEA LYS D 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 8XEA TYR D 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 8XEA PRO D 817 UNP P0DTC2 PHE 817 VARIANT SEQADV 8XEA PRO D 892 UNP P0DTC2 ALA 892 VARIANT SEQADV 8XEA PRO D 899 UNP P0DTC2 ALA 899 VARIANT SEQADV 8XEA PRO D 942 UNP P0DTC2 ALA 942 VARIANT SEQADV 8XEA HIS D 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 8XEA LYS D 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 8XEA PRO D 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 8XEA PRO D 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 8XEA GLY D 1141 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1142 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1143 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1144 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1145 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1146 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TYR D 1147 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ILE D 1148 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO D 1149 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU D 1150 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA D 1151 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO D 1152 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG D 1153 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ASP D 1154 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1155 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN D 1156 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA D 1157 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TYR D 1158 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL D 1159 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG D 1160 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS D 1161 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ASP D 1162 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1163 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU D 1164 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP D 1165 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL D 1166 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU D 1167 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU D 1168 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1169 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA THR D 1170 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE D 1171 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU D 1172 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1173 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG D 1174 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1175 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU D 1176 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU D 1177 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL D 1178 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU D 1179 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE D 1180 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN D 1181 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1182 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO D 1183 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1184 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP D 1185 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1186 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1187 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO D 1188 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN D 1189 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE D 1190 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU D 1191 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS D 1192 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1193 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1194 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1195 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1196 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1197 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1198 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1199 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1200 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1201 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY D 1202 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1203 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1204 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA D 1205 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP D 1206 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER D 1207 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1208 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO D 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN D 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE D 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU D 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS D 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS D 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ILE E 19 UNP P0DTC2 THR 19 VARIANT SEQADV 8XEA GLN E 26 UNP P0DTC2 PRO 26 VARIANT SEQADV 8XEA SER E 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 8XEA ALA E 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 8XEA ASP E 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 8XEA GLN E 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 8XEA GLU E 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 8XEA GLU E 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 8XEA VAL E 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 8XEA HIS E 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 8XEA THR E 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 8XEA ILE E 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 8XEA PHE E 371 UNP P0DTC2 SER 371 VARIANT SEQADV 8XEA PRO E 373 UNP P0DTC2 SER 373 VARIANT SEQADV 8XEA PHE E 375 UNP P0DTC2 SER 375 VARIANT SEQADV 8XEA ALA E 376 UNP P0DTC2 THR 376 VARIANT SEQADV 8XEA ASN E 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 8XEA SER E 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 8XEA ASN E 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 8XEA LYS E 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 8XEA PRO E 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 8XEA SER E 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 8XEA LYS E 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 8XEA ASN E 477 UNP P0DTC2 SER 477 VARIANT SEQADV 8XEA LYS E 478 UNP P0DTC2 THR 478 VARIANT SEQADV 8XEA ALA E 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 8XEA PRO E 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 8XEA SER E 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 8XEA ARG E 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 8XEA TYR E 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 8XEA HIS E 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 8XEA GLY E 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 8XEA TYR E 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 8XEA LYS E 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 8XEA TYR E 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 8XEA PRO E 817 UNP P0DTC2 PHE 817 VARIANT SEQADV 8XEA PRO E 892 UNP P0DTC2 ALA 892 VARIANT SEQADV 8XEA PRO E 899 UNP P0DTC2 ALA 899 VARIANT SEQADV 8XEA PRO E 942 UNP P0DTC2 ALA 942 VARIANT SEQADV 8XEA HIS E 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 8XEA LYS E 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 8XEA PRO E 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 8XEA PRO E 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 8XEA GLY E 1141 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1142 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1143 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1144 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1145 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1146 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TYR E 1147 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ILE E 1148 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO E 1149 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU E 1150 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA E 1151 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO E 1152 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG E 1153 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ASP E 1154 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1155 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN E 1156 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA E 1157 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TYR E 1158 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL E 1159 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG E 1160 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS E 1161 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ASP E 1162 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1163 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU E 1164 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP E 1165 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL E 1166 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU E 1167 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU E 1168 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1169 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA THR E 1170 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE E 1171 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU E 1172 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1173 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG E 1174 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1175 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU E 1176 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU E 1177 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL E 1178 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU E 1179 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE E 1180 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN E 1181 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1182 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO E 1183 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1184 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP E 1185 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1186 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1187 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO E 1188 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN E 1189 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE E 1190 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU E 1191 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS E 1192 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1193 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1194 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1195 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1196 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1197 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1198 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1199 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1200 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1201 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY E 1202 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1203 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1204 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA E 1205 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP E 1206 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER E 1207 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1208 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO E 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN E 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE E 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU E 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS E 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS E 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ILE F 19 UNP P0DTC2 THR 19 VARIANT SEQADV 8XEA GLN F 26 UNP P0DTC2 PRO 26 VARIANT SEQADV 8XEA SER F 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 8XEA ALA F 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 8XEA ASP F 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 8XEA GLN F 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 8XEA GLU F 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 8XEA GLU F 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 8XEA VAL F 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 8XEA HIS F 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 8XEA THR F 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 8XEA ILE F 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 8XEA PHE F 371 UNP P0DTC2 SER 371 VARIANT SEQADV 8XEA PRO F 373 UNP P0DTC2 SER 373 VARIANT SEQADV 8XEA PHE F 375 UNP P0DTC2 SER 375 VARIANT SEQADV 8XEA ALA F 376 UNP P0DTC2 THR 376 VARIANT SEQADV 8XEA ASN F 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 8XEA SER F 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 8XEA ASN F 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 8XEA LYS F 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 8XEA PRO F 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 8XEA SER F 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 8XEA LYS F 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 8XEA ASN F 477 UNP P0DTC2 SER 477 VARIANT SEQADV 8XEA LYS F 478 UNP P0DTC2 THR 478 VARIANT SEQADV 8XEA ALA F 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 8XEA PRO F 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 8XEA SER F 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 8XEA ARG F 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 8XEA TYR F 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 8XEA HIS F 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 8XEA GLY F 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 8XEA TYR F 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 8XEA LYS F 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 8XEA TYR F 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 8XEA PRO F 817 UNP P0DTC2 PHE 817 VARIANT SEQADV 8XEA PRO F 892 UNP P0DTC2 ALA 892 VARIANT SEQADV 8XEA PRO F 899 UNP P0DTC2 ALA 899 VARIANT SEQADV 8XEA PRO F 942 UNP P0DTC2 ALA 942 VARIANT SEQADV 8XEA HIS F 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 8XEA LYS F 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 8XEA PRO F 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 8XEA PRO F 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 8XEA GLY F 1141 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1142 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1143 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1144 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1145 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1146 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TYR F 1147 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ILE F 1148 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO F 1149 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU F 1150 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA F 1151 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO F 1152 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG F 1153 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ASP F 1154 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1155 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN F 1156 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA F 1157 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TYR F 1158 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL F 1159 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG F 1160 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS F 1161 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ASP F 1162 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1163 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU F 1164 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP F 1165 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL F 1166 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU F 1167 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU F 1168 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1169 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA THR F 1170 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE F 1171 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU F 1172 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1173 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ARG F 1174 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1175 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU F 1176 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU F 1177 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA VAL F 1178 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LEU F 1179 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE F 1180 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN F 1181 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1182 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO F 1183 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1184 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP F 1185 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1186 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1187 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO F 1188 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN F 1189 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE F 1190 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU F 1191 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS F 1192 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1193 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1194 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1195 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1196 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1197 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1198 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1199 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1200 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1201 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLY F 1202 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1203 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1204 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA ALA F 1205 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA TRP F 1206 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA SER F 1207 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1208 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PRO F 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLN F 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA PHE F 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA GLU F 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA LYS F 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 8XEA HIS F 1221 UNP P0DTC2 EXPRESSION TAG SEQRES 1 A 117 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 A 117 PRO GLY GLY SER LEU ARG LEU SER CYS ALA VAL SER GLY SEQRES 3 A 117 PHE THR VAL SER ARG ASN TYR MET THR TRP ALA ARG GLN SEQRES 4 A 117 ALA PRO GLY LYS GLY PRO GLU TRP VAL SER VAL ILE TYR SEQRES 5 A 117 PRO GLY GLY SER THR PHE TYR ALA ASP SER VAL LYS GLY SEQRES 6 A 117 ARG PHE THR ILE SER ARG ASP SER SER LYS ASN ILE LEU SEQRES 7 A 117 TYR LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR ALA SEQRES 8 A 117 VAL TYR TYR CYS ALA ARG ASP LEU THR ILE ARG GLY GLU SEQRES 9 A 117 ALA SER TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 B 107 GLU ILE VAL MET THR GLN SER PRO ALA THR LEU ALA VAL SEQRES 2 B 107 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 B 107 GLU SER PHE ASN SER ASN LEU ALA TRP TYR GLN GLN LYS SEQRES 4 B 107 PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SER SEQRES 5 B 107 THR ARG ALA SER ASP VAL PRO ALA ARG PHE SER GLY SER SEQRES 6 B 107 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER VAL SEQRES 7 B 107 GLN SER GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN TYR SEQRES 8 B 107 GLY ASP TRP PRO LEU TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 B 107 VAL GLU ILE SEQRES 1 D 1221 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 D 1221 GLN CYS VAL ASN LEU ILE THR ARG THR GLN LEU PRO GLN SEQRES 3 D 1221 SER TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 D 1221 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 D 1221 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 D 1221 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 D 1221 PHE ASP ASN PRO ALA LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 D 1221 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 D 1221 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 D 1221 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 D 1221 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU ASP VAL SEQRES 12 D 1221 TYR TYR GLN LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 D 1221 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 D 1221 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 D 1221 GLU GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 D 1221 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 D 1221 PRO ILE ASN LEU GLU ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 D 1221 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 D 1221 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 D 1221 TYR LEU THR PRO VAL ASP SER SER SER GLY TRP THR ALA SEQRES 21 D 1221 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 D 1221 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 D 1221 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 D 1221 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 D 1221 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 D 1221 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 D 1221 HIS GLU VAL PHE ASN ALA THR THR PHE ALA SER VAL TYR SEQRES 28 D 1221 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 D 1221 TYR SER VAL ILE TYR ASN PHE ALA PRO PHE PHE ALA PHE SEQRES 30 D 1221 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 D 1221 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 D 1221 GLY ASN GLU VAL SER GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 D 1221 ASN ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 D 1221 THR GLY CYS VAL ILE ALA TRP ASN SER ASN LYS LEU ASP SEQRES 35 D 1221 SER LYS PRO SER GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 D 1221 PHE ARG LYS SER LYS LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 D 1221 SER THR GLU ILE TYR GLN ALA GLY ASN LYS PRO CYS ASN SEQRES 38 D 1221 GLY VAL ALA GLY PRO ASN CYS TYR SER PRO LEU GLN SER SEQRES 39 D 1221 TYR GLY PHE ARG PRO THR TYR GLY VAL GLY HIS GLN PRO SEQRES 40 D 1221 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 D 1221 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 D 1221 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 D 1221 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 D 1221 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 D 1221 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 D 1221 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 D 1221 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 D 1221 TYR GLN GLY VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 D 1221 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 D 1221 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 D 1221 ILE GLY ALA GLU TYR VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 D 1221 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 D 1221 GLN THR ASN SER PRO ARG ARG ALA ARG SER VAL ALA SER SEQRES 54 D 1221 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 D 1221 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 D 1221 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 D 1221 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 D 1221 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 D 1221 GLN TYR GLY SER PHE CYS THR GLN LEU LYS ARG ALA LEU SEQRES 60 D 1221 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 D 1221 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 D 1221 ILE LYS TYR PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 D 1221 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 64 D 1221 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 D 1221 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 D 1221 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 D 1221 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 D 1221 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 D 1221 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 70 D 1221 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 D 1221 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 D 1221 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 D 1221 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 74 D 1221 ASP VAL VAL ASN HIS ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 D 1221 VAL LYS GLN LEU SER SER LYS PHE GLY ALA ILE SER SER SEQRES 76 D 1221 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 D 1221 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 D 1221 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 D 1221 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 D 1221 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 D 1221 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 D 1221 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 D 1221 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 D 1221 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 D 1221 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 D 1221 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 D 1221 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 D 1221 ILE VAL ASN ASN THR VAL TYR ASP PRO GLY GLY SER GLY SEQRES 89 D 1221 GLY SER TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA SEQRES 90 D 1221 TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR SEQRES 91 D 1221 PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO SEQRES 92 D 1221 GLY TRP SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER SEQRES 93 D 1221 GLY GLY GLY SER GLY GLY SER SER ALA TRP SER HIS PRO SEQRES 94 D 1221 GLN PHE GLU LYS HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 E 1221 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 E 1221 GLN CYS VAL ASN LEU ILE THR ARG THR GLN LEU PRO GLN SEQRES 3 E 1221 SER TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 E 1221 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 E 1221 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 E 1221 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 E 1221 PHE ASP ASN PRO ALA LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 E 1221 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 E 1221 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 E 1221 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 E 1221 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU ASP VAL SEQRES 12 E 1221 TYR TYR GLN LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 E 1221 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 E 1221 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 E 1221 GLU GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 E 1221 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 E 1221 PRO ILE ASN LEU GLU ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 E 1221 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 E 1221 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 E 1221 TYR LEU THR PRO VAL ASP SER SER SER GLY TRP THR ALA SEQRES 21 E 1221 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 E 1221 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 E 1221 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 E 1221 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 E 1221 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 E 1221 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 E 1221 HIS GLU VAL PHE ASN ALA THR THR PHE ALA SER VAL TYR SEQRES 28 E 1221 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 E 1221 TYR SER VAL ILE TYR ASN PHE ALA PRO PHE PHE ALA PHE SEQRES 30 E 1221 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 E 1221 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 E 1221 GLY ASN GLU VAL SER GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 E 1221 ASN ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 E 1221 THR GLY CYS VAL ILE ALA TRP ASN SER ASN LYS LEU ASP SEQRES 35 E 1221 SER LYS PRO SER GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 E 1221 PHE ARG LYS SER LYS LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 E 1221 SER THR GLU ILE TYR GLN ALA GLY ASN LYS PRO CYS ASN SEQRES 38 E 1221 GLY VAL ALA GLY PRO ASN CYS TYR SER PRO LEU GLN SER SEQRES 39 E 1221 TYR GLY PHE ARG PRO THR TYR GLY VAL GLY HIS GLN PRO SEQRES 40 E 1221 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 E 1221 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 E 1221 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 E 1221 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 E 1221 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 E 1221 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 E 1221 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 E 1221 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 E 1221 TYR GLN GLY VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 E 1221 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 E 1221 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 E 1221 ILE GLY ALA GLU TYR VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 E 1221 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 E 1221 GLN THR ASN SER PRO ARG ARG ALA ARG SER VAL ALA SER SEQRES 54 E 1221 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 E 1221 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 E 1221 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 E 1221 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 E 1221 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 E 1221 GLN TYR GLY SER PHE CYS THR GLN LEU LYS ARG ALA LEU SEQRES 60 E 1221 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 E 1221 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 E 1221 ILE LYS TYR PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 E 1221 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 64 E 1221 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 E 1221 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 E 1221 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 E 1221 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 E 1221 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 E 1221 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 70 E 1221 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 E 1221 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 E 1221 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 E 1221 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 74 E 1221 ASP VAL VAL ASN HIS ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 E 1221 VAL LYS GLN LEU SER SER LYS PHE GLY ALA ILE SER SER SEQRES 76 E 1221 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 E 1221 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 E 1221 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 E 1221 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 E 1221 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 E 1221 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 E 1221 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 E 1221 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 E 1221 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 E 1221 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 E 1221 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 E 1221 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 E 1221 ILE VAL ASN ASN THR VAL TYR ASP PRO GLY GLY SER GLY SEQRES 89 E 1221 GLY SER TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA SEQRES 90 E 1221 TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR SEQRES 91 E 1221 PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO SEQRES 92 E 1221 GLY TRP SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER SEQRES 93 E 1221 GLY GLY GLY SER GLY GLY SER SER ALA TRP SER HIS PRO SEQRES 94 E 1221 GLN PHE GLU LYS HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 F 1221 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 F 1221 GLN CYS VAL ASN LEU ILE THR ARG THR GLN LEU PRO GLN SEQRES 3 F 1221 SER TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 F 1221 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 F 1221 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 F 1221 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 F 1221 PHE ASP ASN PRO ALA LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 F 1221 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 F 1221 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 F 1221 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 F 1221 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU ASP VAL SEQRES 12 F 1221 TYR TYR GLN LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 F 1221 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 F 1221 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 F 1221 GLU GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 F 1221 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 F 1221 PRO ILE ASN LEU GLU ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 F 1221 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 F 1221 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 F 1221 TYR LEU THR PRO VAL ASP SER SER SER GLY TRP THR ALA SEQRES 21 F 1221 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 F 1221 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 F 1221 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 F 1221 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 F 1221 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 F 1221 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 F 1221 HIS GLU VAL PHE ASN ALA THR THR PHE ALA SER VAL TYR SEQRES 28 F 1221 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 F 1221 TYR SER VAL ILE TYR ASN PHE ALA PRO PHE PHE ALA PHE SEQRES 30 F 1221 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 F 1221 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 F 1221 GLY ASN GLU VAL SER GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 F 1221 ASN ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 F 1221 THR GLY CYS VAL ILE ALA TRP ASN SER ASN LYS LEU ASP SEQRES 35 F 1221 SER LYS PRO SER GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 F 1221 PHE ARG LYS SER LYS LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 F 1221 SER THR GLU ILE TYR GLN ALA GLY ASN LYS PRO CYS ASN SEQRES 38 F 1221 GLY VAL ALA GLY PRO ASN CYS TYR SER PRO LEU GLN SER SEQRES 39 F 1221 TYR GLY PHE ARG PRO THR TYR GLY VAL GLY HIS GLN PRO SEQRES 40 F 1221 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 F 1221 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 F 1221 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 F 1221 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 F 1221 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 F 1221 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 F 1221 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 F 1221 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 F 1221 TYR GLN GLY VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 F 1221 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 F 1221 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 F 1221 ILE GLY ALA GLU TYR VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 F 1221 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 F 1221 GLN THR ASN SER PRO ARG ARG ALA ARG SER VAL ALA SER SEQRES 54 F 1221 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 F 1221 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 F 1221 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 F 1221 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 F 1221 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 F 1221 GLN TYR GLY SER PHE CYS THR GLN LEU LYS ARG ALA LEU SEQRES 60 F 1221 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 F 1221 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 F 1221 ILE LYS TYR PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 F 1221 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 64 F 1221 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 F 1221 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 F 1221 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 F 1221 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 F 1221 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 F 1221 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 70 F 1221 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 F 1221 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 F 1221 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 F 1221 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 74 F 1221 ASP VAL VAL ASN HIS ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 F 1221 VAL LYS GLN LEU SER SER LYS PHE GLY ALA ILE SER SER SEQRES 76 F 1221 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 F 1221 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 F 1221 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 F 1221 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 F 1221 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 F 1221 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 F 1221 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 F 1221 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 F 1221 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 F 1221 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 F 1221 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 F 1221 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 F 1221 ILE VAL ASN ASN THR VAL TYR ASP PRO GLY GLY SER GLY SEQRES 89 F 1221 GLY SER TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA SEQRES 90 F 1221 TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR SEQRES 91 F 1221 PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO SEQRES 92 F 1221 GLY TRP SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER SEQRES 93 F 1221 GLY GLY GLY SER GLY GLY SER SER ALA TRP SER HIS PRO SEQRES 94 F 1221 GLN PHE GLU LYS HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 G 117 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 G 117 PRO GLY GLY SER LEU ARG LEU SER CYS ALA VAL SER GLY SEQRES 3 G 117 PHE THR VAL SER ARG ASN TYR MET THR TRP ALA ARG GLN SEQRES 4 G 117 ALA PRO GLY LYS GLY PRO GLU TRP VAL SER VAL ILE TYR SEQRES 5 G 117 PRO GLY GLY SER THR PHE TYR ALA ASP SER VAL LYS GLY SEQRES 6 G 117 ARG PHE THR ILE SER ARG ASP SER SER LYS ASN ILE LEU SEQRES 7 G 117 TYR LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR ALA SEQRES 8 G 117 VAL TYR TYR CYS ALA ARG ASP LEU THR ILE ARG GLY GLU SEQRES 9 G 117 ALA SER TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 I 107 GLU ILE VAL MET THR GLN SER PRO ALA THR LEU ALA VAL SEQRES 2 I 107 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 I 107 GLU SER PHE ASN SER ASN LEU ALA TRP TYR GLN GLN LYS SEQRES 4 I 107 PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SER SEQRES 5 I 107 THR ARG ALA SER ASP VAL PRO ALA ARG PHE SER GLY SER SEQRES 6 I 107 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER VAL SEQRES 7 I 107 GLN SER GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN TYR SEQRES 8 I 107 GLY ASP TRP PRO LEU TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 I 107 VAL GLU ILE SEQRES 1 H 117 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 H 117 PRO GLY GLY SER LEU ARG LEU SER CYS ALA VAL SER GLY SEQRES 3 H 117 PHE THR VAL SER ARG ASN TYR MET THR TRP ALA ARG GLN SEQRES 4 H 117 ALA PRO GLY LYS GLY PRO GLU TRP VAL SER VAL ILE TYR SEQRES 5 H 117 PRO GLY GLY SER THR PHE TYR ALA ASP SER VAL LYS GLY SEQRES 6 H 117 ARG PHE THR ILE SER ARG ASP SER SER LYS ASN ILE LEU SEQRES 7 H 117 TYR LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR ALA SEQRES 8 H 117 VAL TYR TYR CYS ALA ARG ASP LEU THR ILE ARG GLY GLU SEQRES 9 H 117 ALA SER TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 J 107 GLU ILE VAL MET THR GLN SER PRO ALA THR LEU ALA VAL SEQRES 2 J 107 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 J 107 GLU SER PHE ASN SER ASN LEU ALA TRP TYR GLN GLN LYS SEQRES 4 J 107 PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SER SEQRES 5 J 107 THR ARG ALA SER ASP VAL PRO ALA ARG PHE SER GLY SER SEQRES 6 J 107 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER VAL SEQRES 7 J 107 GLN SER GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN TYR SEQRES 8 J 107 GLY ASP TRP PRO LEU TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 J 107 VAL GLU ILE HELIX 1 AA1 THR A 28 ASN A 32 5 5 HELIX 2 AA2 ARG A 86 THR A 90 5 5 HELIX 3 AA3 ASP D 294 LYS D 304 1 11 HELIX 4 AA4 PRO D 337 ASN D 343 1 7 HELIX 5 AA5 GLU D 406 ILE D 410 5 5 HELIX 6 AA6 CYS D 738 CYS D 743 1 6 HELIX 7 AA7 SER D 746 LEU D 754 1 9 HELIX 8 AA8 PHE D 759 ALA D 783 1 25 HELIX 9 AA9 SER D 816 LYS D 825 1 10 HELIX 10 AB1 ILE D 850 PHE D 855 1 6 HELIX 11 AB2 THR D 866 SER D 884 1 19 HELIX 12 AB3 TRP D 886 ALA D 890 5 5 HELIX 13 AB4 PRO D 897 ASN D 907 1 11 HELIX 14 AB5 GLY D 908 GLY D 910 5 3 HELIX 15 AB6 GLN D 913 ASN D 919 1 7 HELIX 16 AB7 ASN D 919 THR D 941 1 23 HELIX 17 AB8 LEU D 945 LYS D 964 1 20 HELIX 18 AB9 LEU D 977 LEU D 984 1 8 HELIX 19 AC1 ASP D 985 ILE D 993 1 9 HELIX 20 AC2 ASP D 994 CYS D 1032 1 39 HELIX 21 AC3 ASP E 294 LYS E 304 1 11 HELIX 22 AC4 PRO E 337 ASN E 343 1 7 HELIX 23 AC5 SER E 383 LEU E 387 5 5 HELIX 24 AC6 GLU E 406 ILE E 410 5 5 HELIX 25 AC7 SER E 746 LEU E 754 1 9 HELIX 26 AC8 PHE E 759 ALA E 783 1 25 HELIX 27 AC9 SER E 816 VAL E 826 1 11 HELIX 28 AD1 CYS E 851 PHE E 855 1 5 HELIX 29 AD2 THR E 866 SER E 884 1 19 HELIX 30 AD3 TRP E 886 ALA E 890 5 5 HELIX 31 AD4 PRO E 897 ASN E 907 1 11 HELIX 32 AD5 GLY E 908 GLY E 910 5 3 HELIX 33 AD6 GLN E 913 THR E 941 1 29 HELIX 34 AD7 LEU E 945 LYS E 964 1 20 HELIX 35 AD8 LEU E 977 LEU E 984 1 8 HELIX 36 AD9 ASP E 985 GLU E 988 5 4 HELIX 37 AE1 ALA E 989 CYS E 1032 1 44 HELIX 38 AE2 ASP F 294 LYS F 304 1 11 HELIX 39 AE3 PHE F 338 ASN F 343 1 6 HELIX 40 AE4 ASP F 364 ASN F 370 1 7 HELIX 41 AE5 THR F 385 ASP F 389 5 5 HELIX 42 AE6 GLU F 406 ILE F 410 5 5 HELIX 43 AE7 ASN F 417 ASN F 422 1 6 HELIX 44 AE8 ASP F 737 CYS F 743 1 7 HELIX 45 AE9 SER F 746 GLY F 757 1 12 HELIX 46 AF1 PHE F 759 ALA F 783 1 25 HELIX 47 AF2 SER F 816 VAL F 826 1 11 HELIX 48 AF3 ILE F 850 PHE F 855 1 6 HELIX 49 AF4 THR F 866 SER F 884 1 19 HELIX 50 AF5 TRP F 886 ALA F 890 5 5 HELIX 51 AF6 PRO F 897 GLY F 908 1 12 HELIX 52 AF7 GLN F 913 THR F 941 1 29 HELIX 53 AF8 LEU F 945 GLN F 965 1 21 HELIX 54 AF9 LEU F 977 LEU F 984 1 8 HELIX 55 AG1 ASP F 985 VAL F 1033 1 49 HELIX 56 AG2 ARG G 86 THR G 90 5 5 HELIX 57 AG3 ARG H 86 THR H 90 5 5 HELIX 58 AG4 GLY J 92 TRP J 94 5 3 SHEET 1 AA1 4 GLN A 3 SER A 7 0 SHEET 2 AA1 4 SER A 17 SER A 25 -1 O SER A 25 N GLN A 3 SHEET 3 AA1 4 ILE A 77 ASN A 83 -1 O LEU A 80 N LEU A 20 SHEET 4 AA1 4 PHE A 67 ASP A 72 -1 N SER A 70 O TYR A 79 SHEET 1 AA2 6 LEU A 11 VAL A 12 0 SHEET 2 AA2 6 THR A 111 VAL A 115 1 O THR A 114 N VAL A 12 SHEET 3 AA2 6 ALA A 91 ARG A 97 -1 N TYR A 93 O THR A 111 SHEET 4 AA2 6 MET A 34 GLN A 39 -1 N ALA A 37 O TYR A 94 SHEET 5 AA2 6 SER A 49 ILE A 51 -1 O SER A 49 N TRP A 36 SHEET 6 AA2 6 THR A 57 TYR A 59 -1 O PHE A 58 N VAL A 50 SHEET 1 AA3 4 PRO A 45 GLU A 46 0 SHEET 2 AA3 4 MET A 34 GLN A 39 -1 N ARG A 38 O GLU A 46 SHEET 3 AA3 4 ALA A 91 ARG A 97 -1 O TYR A 94 N ALA A 37 SHEET 4 AA3 4 SER A 106 TRP A 107 -1 O SER A 106 N ARG A 97 SHEET 1 AA4 4 THR B 5 SER B 7 0 SHEET 2 AA4 4 ALA B 19 ARG B 24 -1 O ARG B 24 N THR B 5 SHEET 3 AA4 4 GLU B 70 ILE B 75 -1 O ILE B 75 N ALA B 19 SHEET 4 AA4 4 PHE B 62 SER B 65 -1 N SER B 63 O THR B 74 SHEET 1 AA5 4 THR B 53 ARG B 54 0 SHEET 2 AA5 4 ARG B 45 TYR B 49 -1 N TYR B 49 O THR B 53 SHEET 3 AA5 4 LEU B 33 GLN B 38 -1 N TRP B 35 O LEU B 47 SHEET 4 AA5 4 VAL B 85 GLN B 90 -1 O GLN B 89 N ALA B 34 SHEET 1 AA6 7 TYR D 28 SER D 31 0 SHEET 2 AA6 7 SER D 60 TRP D 64 -1 O SER D 60 N SER D 31 SHEET 3 AA6 7 TYR D 266 TYR D 269 -1 O VAL D 267 N THR D 63 SHEET 4 AA6 7 VAL D 90 SER D 94 -1 N TYR D 91 O GLY D 268 SHEET 5 AA6 7 ASN D 188 LYS D 195 -1 O PHE D 192 N PHE D 92 SHEET 6 AA6 7 PHE D 201 PRO D 209 -1 O LYS D 202 N LYS D 195 SHEET 7 AA6 7 GLU D 224 LEU D 229 -1 O GLU D 224 N SER D 205 SHEET 1 AA7 2 GLN D 52 PHE D 55 0 SHEET 2 AA7 2 GLN D 271 THR D 274 -1 O GLN D 271 N PHE D 55 SHEET 1 AA8 4 VAL D 127 CYS D 131 0 SHEET 2 AA8 4 SER D 116 VAL D 120 -1 N LEU D 118 O LYS D 129 SHEET 3 AA8 4 ILE D 101 GLY D 107 -1 N PHE D 106 O LEU D 117 SHEET 4 AA8 4 ARG D 237 LEU D 242 -1 O GLN D 239 N ILE D 105 SHEET 1 AA9 2 LEU D 277 TYR D 279 0 SHEET 2 AA9 2 ILE D 285 ALA D 288 -1 O THR D 286 N LYS D 278 SHEET 1 AB1 5 GLY D 311 GLN D 314 0 SHEET 2 AB1 5 VAL D 595 THR D 599 -1 O THR D 599 N GLY D 311 SHEET 3 AB1 5 ALA D 609 GLN D 613 -1 O LEU D 611 N SER D 596 SHEET 4 AB1 5 GLY D 648 ILE D 651 -1 O ILE D 651 N VAL D 610 SHEET 5 AB1 5 VAL D 642 GLN D 644 -1 N PHE D 643 O LEU D 650 SHEET 1 AB2 5 SER D 325 ARG D 328 0 SHEET 2 AB2 5 VAL D 539 PHE D 543 1 O ASN D 540 N ILE D 326 SHEET 3 AB2 5 LEU D 546 THR D 553 -1 O GLY D 550 N VAL D 539 SHEET 4 AB2 5 ILE D 584 THR D 588 -1 O THR D 588 N VAL D 551 SHEET 5 AB2 5 ALA D 575 ARG D 577 -1 N VAL D 576 O LEU D 585 SHEET 1 AB3 3 ASN D 394 ILE D 402 0 SHEET 2 AB3 3 TYR D 508 GLU D 516 -1 O GLU D 516 N ASN D 394 SHEET 3 AB3 3 GLY D 431 CYS D 432 -1 N CYS D 432 O LEU D 513 SHEET 1 AB4 2 LEU D 452 ARG D 454 0 SHEET 2 AB4 2 LEU D 492 SER D 494 -1 O GLN D 493 N TYR D 453 SHEET 1 AB5 2 TYR D 473 GLN D 474 0 SHEET 2 AB5 2 CYS D 488 TYR D 489 -1 O TYR D 489 N TYR D 473 SHEET 1 AB6 4 GLU D 654 TYR D 660 0 SHEET 2 AB6 4 ILE D 692 MET D 697 1 O ALA D 694 N GLU D 654 SHEET 3 AB6 4 ILE D 670 TYR D 674 -1 N CYS D 671 O TYR D 695 SHEET 4 AB6 4 ILE D 664 PRO D 665 -1 N ILE D 664 O ALA D 672 SHEET 1 AB7 2 ALA D 701 GLU D 702 0 SHEET 2 AB7 2 GLN E 787 ILE E 788 1 O ILE E 788 N ALA D 701 SHEET 1 AB8 3 SER D 711 PRO D 728 0 SHEET 2 AB8 3 GLY D1059 THR D1076 -1 O ALA D1070 N ASN D 717 SHEET 3 AB8 3 TYR D1047 ALA D1056 -1 N TYR D1047 O TYR D1067 SHEET 1 AB9 2 LYS D 733 SER D 735 0 SHEET 2 AB9 2 THR D 859 LEU D 861 -1 O THR D 859 N SER D 735 SHEET 1 AC1 2 GLN D 787 ILE D 788 0 SHEET 2 AC1 2 ALA F 701 GLU F 702 1 O ALA F 701 N ILE D 788 SHEET 1 AC2 4 THR D1120 ASN D1125 0 SHEET 2 AC2 4 LYS D1086 PRO D1090 -1 N PHE D1089 O PHE D1121 SHEET 3 AC2 4 ILE D1081 HIS D1083 -1 N HIS D1083 O LYS D1086 SHEET 4 AC2 4 VAL D1133 ASN D1134 1 O VAL D1133 N CYS D1082 SHEET 1 AC3 2 VAL D1094 SER D1097 0 SHEET 2 AC3 2 TRP D1102 THR D1105 -1 O PHE D1103 N VAL D1096 SHEET 1 AC4 7 TYR E 28 SER E 31 0 SHEET 2 AC4 7 SER E 60 TRP E 64 -1 O VAL E 62 N THR E 29 SHEET 3 AC4 7 TYR E 266 TYR E 269 -1 O VAL E 267 N THR E 63 SHEET 4 AC4 7 VAL E 90 SER E 94 -1 N TYR E 91 O GLY E 268 SHEET 5 AC4 7 ASN E 188 LYS E 195 -1 O PHE E 192 N PHE E 92 SHEET 6 AC4 7 TYR E 200 PRO E 209 -1 O LYS E 206 N GLU E 191 SHEET 7 AC4 7 GLU E 224 PRO E 230 -1 O GLU E 224 N SER E 205 SHEET 1 AC5 2 GLN E 52 PHE E 55 0 SHEET 2 AC5 2 GLN E 271 THR E 274 -1 O ARG E 273 N ASP E 53 SHEET 1 AC6 6 LEU E 84 PRO E 85 0 SHEET 2 AC6 6 ARG E 237 GLN E 239 -1 O PHE E 238 N LEU E 84 SHEET 3 AC6 6 TRP E 104 GLY E 107 -1 N GLY E 107 O ARG E 237 SHEET 4 AC6 6 SER E 116 VAL E 120 -1 O LEU E 117 N PHE E 106 SHEET 5 AC6 6 VAL E 126 CYS E 131 -1 O LYS E 129 N LEU E 118 SHEET 6 AC6 6 VAL E 171 SER E 172 -1 O SER E 172 N VAL E 126 SHEET 1 AC7 2 LEU E 277 TYR E 279 0 SHEET 2 AC7 2 ILE E 285 ALA E 288 -1 O THR E 286 N LYS E 278 SHEET 1 AC8 5 TYR E 313 GLN E 314 0 SHEET 2 AC8 5 VAL E 595 ILE E 598 -1 O VAL E 597 N TYR E 313 SHEET 3 AC8 5 ALA E 609 GLN E 613 -1 O ALA E 609 N ILE E 598 SHEET 4 AC8 5 GLY E 648 ILE E 651 -1 O CYS E 649 N TYR E 612 SHEET 5 AC8 5 VAL E 642 PHE E 643 -1 N PHE E 643 O LEU E 650 SHEET 1 AC9 5 SER E 325 ARG E 328 0 SHEET 2 AC9 5 VAL E 539 PHE E 543 1 O ASN E 540 N ILE E 326 SHEET 3 AC9 5 THR E 547 GLU E 554 -1 O GLY E 548 N PHE E 541 SHEET 4 AC9 5 ILE E 584 THR E 588 -1 O THR E 588 N VAL E 551 SHEET 5 AC9 5 ALA E 575 ARG E 577 -1 N VAL E 576 O LEU E 585 SHEET 1 AD1 2 CYS E 391 PHE E 392 0 SHEET 2 AD1 2 VAL E 524 CYS E 525 -1 O VAL E 524 N PHE E 392 SHEET 1 AD2 3 ASN E 394 ILE E 402 0 SHEET 2 AD2 3 TYR E 508 GLU E 516 -1 O GLU E 516 N ASN E 394 SHEET 3 AD2 3 GLY E 431 ALA E 435 -1 N ILE E 434 O VAL E 511 SHEET 1 AD3 2 LEU E 452 ARG E 454 0 SHEET 2 AD3 2 LEU E 492 SER E 494 -1 O GLN E 493 N TYR E 453 SHEET 1 AD4 2 TYR E 473 GLN E 474 0 SHEET 2 AD4 2 CYS E 488 TYR E 489 -1 O TYR E 489 N TYR E 473 SHEET 1 AD5 4 GLU E 654 TYR E 660 0 SHEET 2 AD5 4 ILE E 692 MET E 697 1 O ALA E 694 N GLU E 654 SHEET 3 AD5 4 ILE E 670 TYR E 674 -1 N CYS E 671 O TYR E 695 SHEET 4 AD5 4 ILE E 664 PRO E 665 -1 N ILE E 664 O ALA E 672 SHEET 1 AD6 4 SER E 711 PRO E 715 0 SHEET 2 AD6 4 GLU E1072 THR E1077 -1 O LYS E1073 N ILE E 714 SHEET 3 AD6 4 VAL E1094 SER E1097 -1 O SER E1097 N THR E1076 SHEET 4 AD6 4 TRP E1102 THR E1105 -1 O PHE E1103 N VAL E1096 SHEET 1 AD7 3 PHE E 718 PRO E 728 0 SHEET 2 AD7 3 GLY E1059 PRO E1069 -1 O VAL E1060 N LEU E 727 SHEET 3 AD7 3 TYR E1047 ALA E1056 -1 N TYR E1047 O TYR E1067 SHEET 1 AD8 2 THR E 734 VAL E 736 0 SHEET 2 AD8 2 LEU E 858 VAL E 860 -1 O THR E 859 N SER E 735 SHEET 1 AD9 4 THR E1120 ASN E1125 0 SHEET 2 AD9 4 LYS E1086 PRO E1090 -1 N PHE E1089 O PHE E1121 SHEET 3 AD9 4 ILE E1081 HIS E1083 -1 N ILE E1081 O HIS E1088 SHEET 4 AD9 4 VAL E1133 ASN E1134 1 O VAL E1133 N CYS E1082 SHEET 1 AE1 7 TYR F 28 SER F 31 0 SHEET 2 AE1 7 SER F 60 TRP F 64 -1 O SER F 60 N SER F 31 SHEET 3 AE1 7 TYR F 266 TYR F 269 -1 O VAL F 267 N THR F 63 SHEET 4 AE1 7 VAL F 90 THR F 95 -1 N TYR F 91 O GLY F 268 SHEET 5 AE1 7 ASN F 188 LYS F 195 -1 O PHE F 192 N PHE F 92 SHEET 6 AE1 7 TYR F 200 PRO F 209 -1 O LYS F 202 N LYS F 195 SHEET 7 AE1 7 GLU F 224 PRO F 230 -1 O GLU F 224 N SER F 205 SHEET 1 AE2 2 GLN F 52 PHE F 55 0 SHEET 2 AE2 2 GLN F 271 THR F 274 -1 O GLN F 271 N PHE F 55 SHEET 1 AE3 6 LEU F 84 PRO F 85 0 SHEET 2 AE3 6 ARG F 237 GLN F 239 -1 O PHE F 238 N LEU F 84 SHEET 3 AE3 6 TRP F 104 GLY F 107 -1 N ILE F 105 O GLN F 239 SHEET 4 AE3 6 SER F 116 VAL F 120 -1 O LEU F 117 N PHE F 106 SHEET 5 AE3 6 VAL F 126 CYS F 131 -1 O LYS F 129 N LEU F 118 SHEET 6 AE3 6 VAL F 171 SER F 172 -1 O SER F 172 N VAL F 126 SHEET 1 AE4 2 LEU F 277 TYR F 279 0 SHEET 2 AE4 2 ILE F 285 ALA F 288 -1 O THR F 286 N LYS F 278 SHEET 1 AE5 5 TYR F 313 GLN F 314 0 SHEET 2 AE5 5 VAL F 595 ILE F 598 -1 O VAL F 597 N TYR F 313 SHEET 3 AE5 5 ALA F 609 GLN F 613 -1 O ALA F 609 N ILE F 598 SHEET 4 AE5 5 GLY F 648 ILE F 651 -1 O CYS F 649 N TYR F 612 SHEET 5 AE5 5 VAL F 642 GLN F 644 -1 N PHE F 643 O LEU F 650 SHEET 1 AE6 5 SER F 325 ARG F 328 0 SHEET 2 AE6 5 VAL F 539 PHE F 543 1 O ASN F 540 N ILE F 326 SHEET 3 AE6 5 LEU F 546 THR F 553 -1 O GLY F 548 N PHE F 541 SHEET 4 AE6 5 ILE F 584 THR F 588 -1 O THR F 588 N VAL F 551 SHEET 5 AE6 5 ALA F 575 ARG F 577 -1 N VAL F 576 O LEU F 585 SHEET 1 AE7 3 ASN F 394 ARG F 403 0 SHEET 2 AE7 3 PRO F 507 GLU F 516 -1 O VAL F 512 N ASP F 398 SHEET 3 AE7 3 THR F 430 ALA F 435 -1 N THR F 430 O PHE F 515 SHEET 1 AE8 2 LEU F 452 ARG F 454 0 SHEET 2 AE8 2 LEU F 492 SER F 494 -1 O GLN F 493 N TYR F 453 SHEET 1 AE9 2 TYR F 473 GLN F 474 0 SHEET 2 AE9 2 CYS F 488 TYR F 489 -1 O TYR F 489 N TYR F 473 SHEET 1 AF1 4 GLU F 654 TYR F 660 0 SHEET 2 AF1 4 ILE F 692 MET F 697 1 O ALA F 694 N GLU F 654 SHEET 3 AF1 4 ILE F 670 TYR F 674 -1 N CYS F 671 O TYR F 695 SHEET 4 AF1 4 ILE F 664 PRO F 665 -1 N ILE F 664 O ALA F 672 SHEET 1 AF2 3 SER F 711 PRO F 728 0 SHEET 2 AF2 3 GLY F1059 THR F1076 -1 O GLN F1071 N THR F 716 SHEET 3 AF2 3 TYR F1047 ALA F1056 -1 N TYR F1047 O TYR F1067 SHEET 1 AF3 4 THR F1120 VAL F1122 0 SHEET 2 AF3 4 LYS F1086 PRO F1090 -1 N PHE F1089 O PHE F1121 SHEET 3 AF3 4 ILE F1081 HIS F1083 -1 N HIS F1083 O LYS F1086 SHEET 4 AF3 4 VAL F1133 ASN F1134 1 O VAL F1133 N CYS F1082 SHEET 1 AF4 2 VAL F1094 SER F1097 0 SHEET 2 AF4 2 TRP F1102 THR F1105 -1 O PHE F1103 N VAL F1096 SHEET 1 AF5 4 GLN G 3 SER G 7 0 SHEET 2 AF5 4 SER G 17 SER G 25 -1 O SER G 25 N GLN G 3 SHEET 3 AF5 4 ILE G 77 ASN G 83 -1 O MET G 82 N LEU G 18 SHEET 4 AF5 4 PHE G 67 ASP G 72 -1 N SER G 70 O TYR G 79 SHEET 1 AF6 6 LEU G 11 VAL G 12 0 SHEET 2 AF6 6 THR G 111 VAL G 115 1 O THR G 114 N VAL G 12 SHEET 3 AF6 6 ALA G 91 ARG G 97 -1 N TYR G 93 O THR G 111 SHEET 4 AF6 6 MET G 34 GLN G 39 -1 N THR G 35 O ALA G 96 SHEET 5 AF6 6 SER G 49 ILE G 51 -1 O SER G 49 N TRP G 36 SHEET 6 AF6 6 THR G 57 TYR G 59 -1 O PHE G 58 N VAL G 50 SHEET 1 AF7 4 PRO G 45 GLU G 46 0 SHEET 2 AF7 4 MET G 34 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 3 AF7 4 ALA G 91 ARG G 97 -1 O ALA G 96 N THR G 35 SHEET 4 AF7 4 SER G 106 TRP G 107 -1 O SER G 106 N ARG G 97 SHEET 1 AF8 4 THR I 5 SER I 7 0 SHEET 2 AF8 4 ALA I 19 ARG I 24 -1 O ARG I 24 N THR I 5 SHEET 3 AF8 4 GLU I 70 ILE I 75 -1 O LEU I 73 N LEU I 21 SHEET 4 AF8 4 PHE I 62 SER I 65 -1 N SER I 63 O THR I 74 SHEET 1 AF9 3 ARG I 45 TYR I 49 0 SHEET 2 AF9 3 LEU I 33 GLN I 38 -1 N TRP I 35 O LEU I 47 SHEET 3 AF9 3 VAL I 85 GLN I 90 -1 O GLN I 89 N ALA I 34 SHEET 1 AG1 4 GLN H 3 SER H 7 0 SHEET 2 AG1 4 SER H 17 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AG1 4 ILE H 77 ASN H 83 -1 O LEU H 80 N LEU H 20 SHEET 4 AG1 4 PHE H 67 ASP H 72 -1 N SER H 70 O TYR H 79 SHEET 1 AG2 5 LEU H 11 VAL H 12 0 SHEET 2 AG2 5 THR H 111 VAL H 115 1 O THR H 114 N VAL H 12 SHEET 3 AG2 5 ALA H 91 ARG H 97 -1 N TYR H 93 O THR H 111 SHEET 4 AG2 5 THR H 35 GLN H 39 -1 N THR H 35 O ALA H 96 SHEET 5 AG2 5 PRO H 45 GLU H 46 -1 O GLU H 46 N ARG H 38 SHEET 1 AG3 4 LEU H 11 VAL H 12 0 SHEET 2 AG3 4 THR H 111 VAL H 115 1 O THR H 114 N VAL H 12 SHEET 3 AG3 4 ALA H 91 ARG H 97 -1 N TYR H 93 O THR H 111 SHEET 4 AG3 4 SER H 106 TRP H 107 -1 O SER H 106 N ARG H 97 SHEET 1 AG4 2 SER H 49 ILE H 51 0 SHEET 2 AG4 2 THR H 57 TYR H 59 -1 O PHE H 58 N VAL H 50 SHEET 1 AG5 4 MET J 4 SER J 7 0 SHEET 2 AG5 4 ALA J 19 ALA J 25 -1 O SER J 22 N SER J 7 SHEET 3 AG5 4 GLU J 70 ILE J 75 -1 O LEU J 73 N LEU J 21 SHEET 4 AG5 4 PHE J 62 SER J 65 -1 N SER J 65 O THR J 72 SHEET 1 AG6 4 THR J 53 ARG J 54 0 SHEET 2 AG6 4 ARG J 45 TYR J 49 -1 N TYR J 49 O THR J 53 SHEET 3 AG6 4 LEU J 33 GLN J 38 -1 N GLN J 37 O ARG J 45 SHEET 4 AG6 4 VAL J 85 GLN J 90 -1 O VAL J 85 N GLN J 38 SSBOND 1 CYS A 22 CYS A 95 1555 1555 2.03 SSBOND 2 CYS B 23 CYS B 88 1555 1555 2.03 SSBOND 3 CYS D 15 CYS D 136 1555 1555 2.03 SSBOND 4 CYS D 131 CYS D 166 1555 1555 2.03 SSBOND 5 CYS D 291 CYS D 301 1555 1555 2.03 SSBOND 6 CYS D 336 CYS D 361 1555 1555 2.03 SSBOND 7 CYS D 379 CYS D 432 1555 1555 2.03 SSBOND 8 CYS D 391 CYS D 525 1555 1555 2.03 SSBOND 9 CYS D 480 CYS D 488 1555 1555 2.03 SSBOND 10 CYS D 538 CYS D 590 1555 1555 2.03 SSBOND 11 CYS D 617 CYS D 649 1555 1555 2.03 SSBOND 12 CYS D 662 CYS D 671 1555 1555 2.03 SSBOND 13 CYS D 738 CYS D 760 1555 1555 2.03 SSBOND 14 CYS D 743 CYS D 749 1555 1555 2.03 SSBOND 15 CYS D 1032 CYS D 1043 1555 1555 2.03 SSBOND 16 CYS D 1082 CYS D 1126 1555 1555 2.03 SSBOND 17 CYS E 15 CYS E 136 1555 1555 2.03 SSBOND 18 CYS E 131 CYS E 166 1555 1555 2.05 SSBOND 19 CYS E 291 CYS E 301 1555 1555 2.03 SSBOND 20 CYS E 336 CYS E 361 1555 1555 2.03 SSBOND 21 CYS E 379 CYS E 432 1555 1555 2.03 SSBOND 22 CYS E 391 CYS E 525 1555 1555 2.03 SSBOND 23 CYS E 480 CYS E 488 1555 1555 2.03 SSBOND 24 CYS E 538 CYS E 590 1555 1555 2.03 SSBOND 25 CYS E 617 CYS E 649 1555 1555 2.03 SSBOND 26 CYS E 662 CYS E 671 1555 1555 2.03 SSBOND 27 CYS E 738 CYS E 760 1555 1555 2.04 SSBOND 28 CYS E 743 CYS E 749 1555 1555 2.03 SSBOND 29 CYS E 1032 CYS E 1043 1555 1555 2.03 SSBOND 30 CYS E 1082 CYS E 1126 1555 1555 2.03 SSBOND 31 CYS F 15 CYS F 136 1555 1555 2.03 SSBOND 32 CYS F 131 CYS F 166 1555 1555 2.03 SSBOND 33 CYS F 291 CYS F 301 1555 1555 2.03 SSBOND 34 CYS F 336 CYS F 361 1555 1555 2.04 SSBOND 35 CYS F 379 CYS F 432 1555 1555 2.03 SSBOND 36 CYS F 391 CYS F 525 1555 1555 2.03 SSBOND 37 CYS F 480 CYS F 488 1555 1555 2.03 SSBOND 38 CYS F 538 CYS F 590 1555 1555 2.03 SSBOND 39 CYS F 617 CYS F 649 1555 1555 2.03 SSBOND 40 CYS F 662 CYS F 671 1555 1555 2.03 SSBOND 41 CYS F 738 CYS F 760 1555 1555 2.03 SSBOND 42 CYS F 743 CYS F 749 1555 1555 2.03 SSBOND 43 CYS F 1032 CYS F 1043 1555 1555 2.03 SSBOND 44 CYS F 1082 CYS F 1126 1555 1555 2.03 SSBOND 45 CYS G 22 CYS G 95 1555 1555 2.03 SSBOND 46 CYS I 23 CYS I 88 1555 1555 2.03 SSBOND 47 CYS H 22 CYS H 95 1555 1555 2.03 SSBOND 48 CYS J 23 CYS J 88 1555 1555 2.03 CISPEP 1 SER B 7 PRO B 8 0 -3.06 CISPEP 2 TRP B 94 PRO B 95 0 4.81 CISPEP 3 SER I 7 PRO I 8 0 -3.31 CISPEP 4 TRP I 94 PRO I 95 0 3.09 CISPEP 5 SER J 7 PRO J 8 0 -6.12 CISPEP 6 TRP J 94 PRO J 95 0 6.05 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000