HEADER MEMBRANE PROTEIN 14-DEC-23 8XFP TITLE THE PENTAMERA COMPLEX OF LGR4-RSPO2-ZNRF3(DELTA RING) COMPND MOL_ID: 1; COMPND 2 MOLECULE: LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR COMPND 3 4; COMPND 4 CHAIN: A; COMPND 5 SYNONYM: G-PROTEIN COUPLED RECEPTOR 48; COMPND 6 ENGINEERED: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: NANOBODY NB52; COMPND 9 CHAIN: E; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: E3 UBIQUITIN-PROTEIN LIGASE ZNRF3; COMPND 13 CHAIN: C, H; COMPND 14 SYNONYM: RING FINGER PROTEIN 203,RING-TYPE E3 UBIQUITIN TRANSFERASE COMPND 15 ZNRF3,ZINC/RING FINGER PROTEIN 3; COMPND 16 EC: 2.3.2.27; COMPND 17 ENGINEERED: YES; COMPND 18 MOL_ID: 4; COMPND 19 MOLECULE: R-SPONDIN-2; COMPND 20 CHAIN: G, J; COMPND 21 SYNONYM: CYSTEINE-RICH AND SINGLE THROMBOSPONDIN DOMAIN-CONTAINING COMPND 22 PROTEIN 2,CRISTIN-2,MCRISTIN-2,ROOF PLATE-SPECIFIC SPONDIN-2; COMPND 23 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: LGR4, GPR48; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: CAMELUS BACTRIANUS; SOURCE 10 ORGANISM_TAXID: 9837; SOURCE 11 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_COMMON: HUMAN; SOURCE 16 ORGANISM_TAXID: 9606; SOURCE 17 GENE: ZNRF3, KIAA1133, RNF203; SOURCE 18 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 20 MOL_ID: 4; SOURCE 21 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 22 ORGANISM_COMMON: HUMAN; SOURCE 23 ORGANISM_TAXID: 9606; SOURCE 24 GENE: RSPO2; SOURCE 25 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS LGR4-RSPO2-ZNRF3(DELTA RING), MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR Y.GENG,L.WANG REVDAT 1 04-DEC-24 8XFP 0 JRNL AUTH Y.GENG JRNL TITL THE PENTAMERA COMPLEX OF LGR4-RSPO2-ZNRF3(DELTA RING) JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.21 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.210 REMARK 3 NUMBER OF PARTICLES : 73170 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8XFP COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 22-DEC-23. REMARK 100 THE DEPOSITION ID IS D_1300043397. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : THE PENTAMER A COMPLEX OF LGR4 REMARK 245 -RSPO2-ZNRF3(DELTA RING DOMAIN) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TECNAI F30 REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 194.40 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, E, C, G, H, J REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 PRO A 2 REMARK 465 GLY A 3 REMARK 465 PRO A 4 REMARK 465 LEU A 5 REMARK 465 GLY A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 CYS A 9 REMARK 465 PHE A 10 REMARK 465 LEU A 11 REMARK 465 ALA A 12 REMARK 465 LEU A 13 REMARK 465 GLY A 14 REMARK 465 LEU A 15 REMARK 465 LEU A 16 REMARK 465 GLY A 17 REMARK 465 SER A 18 REMARK 465 ALA A 19 REMARK 465 GLY A 20 REMARK 465 PRO A 21 REMARK 465 SER A 22 REMARK 465 GLY A 23 REMARK 465 ALA A 24 REMARK 465 ALA A 25 REMARK 465 PRO A 26 REMARK 465 PRO A 27 REMARK 465 LEU A 28 REMARK 465 CYS A 29 REMARK 465 ALA A 30 REMARK 465 ALA A 31 REMARK 465 PRO A 32 REMARK 465 ASP A 477 REMARK 465 SER A 478 REMARK 465 TYR A 479 REMARK 465 ALA A 480 REMARK 465 ASN A 481 REMARK 465 LEU A 482 REMARK 465 ASN A 483 REMARK 465 THR A 484 REMARK 465 GLU A 485 REMARK 465 ASP A 486 REMARK 465 ASN A 487 REMARK 465 SER A 488 REMARK 465 LEU A 489 REMARK 465 GLN A 490 REMARK 465 ASP A 491 REMARK 465 HIS A 492 REMARK 465 SER A 493 REMARK 465 VAL A 494 REMARK 465 ALA A 495 REMARK 465 GLN A 496 REMARK 465 GLU A 497 REMARK 465 LYS A 498 REMARK 465 GLY A 499 REMARK 465 THR A 500 REMARK 465 ALA A 501 REMARK 465 ASP A 502 REMARK 465 ALA A 503 REMARK 465 ALA A 504 REMARK 465 ASN A 505 REMARK 465 VAL A 506 REMARK 465 THR A 507 REMARK 465 SER A 508 REMARK 465 THR A 509 REMARK 465 LEU A 510 REMARK 465 GLU A 511 REMARK 465 ASN A 512 REMARK 465 GLU A 513 REMARK 465 GLU A 514 REMARK 465 HIS A 515 REMARK 465 ILE A 650 REMARK 465 MET A 651 REMARK 465 LYS A 652 REMARK 465 ASN A 653 REMARK 465 GLY A 654 REMARK 465 LYS A 655 REMARK 465 SER A 656 REMARK 465 LYS A 734 REMARK 465 GLU A 735 REMARK 465 ASP A 736 REMARK 465 LEU A 737 REMARK 465 SER A 738 REMARK 465 GLU A 739 REMARK 465 ASN A 740 REMARK 465 SER A 741 REMARK 465 LYS A 821 REMARK 465 LYS A 822 REMARK 465 SER A 823 REMARK 465 GLY A 824 REMARK 465 SER A 825 REMARK 465 VAL A 826 REMARK 465 SER A 827 REMARK 465 VAL A 828 REMARK 465 SER A 829 REMARK 465 ILE A 830 REMARK 465 SER A 831 REMARK 465 SER A 832 REMARK 465 GLN A 833 REMARK 465 GLY A 834 REMARK 465 GLY A 835 REMARK 465 CYS A 836 REMARK 465 LEU A 837 REMARK 465 GLU A 838 REMARK 465 GLN A 839 REMARK 465 ASP A 840 REMARK 465 PHE A 841 REMARK 465 TYR A 842 REMARK 465 TYR A 843 REMARK 465 ASP A 844 REMARK 465 CYS A 845 REMARK 465 GLY A 846 REMARK 465 MET A 847 REMARK 465 TYR A 848 REMARK 465 SER A 849 REMARK 465 HIS A 850 REMARK 465 LEU A 851 REMARK 465 GLN A 852 REMARK 465 GLY A 853 REMARK 465 ASN A 854 REMARK 465 LEU A 855 REMARK 465 THR A 856 REMARK 465 VAL A 857 REMARK 465 CYS A 858 REMARK 465 ASP A 859 REMARK 465 CYS A 860 REMARK 465 CYS A 861 REMARK 465 GLU A 862 REMARK 465 SER A 863 REMARK 465 PHE A 864 REMARK 465 LEU A 865 REMARK 465 LEU A 866 REMARK 465 THR A 867 REMARK 465 LYS A 868 REMARK 465 PRO A 869 REMARK 465 VAL A 870 REMARK 465 SER A 871 REMARK 465 CYS A 872 REMARK 465 LYS A 873 REMARK 465 HIS A 874 REMARK 465 LEU A 875 REMARK 465 ILE A 876 REMARK 465 LYS A 877 REMARK 465 SER A 878 REMARK 465 HIS A 879 REMARK 465 SER A 880 REMARK 465 CYS A 881 REMARK 465 PRO A 882 REMARK 465 ALA A 883 REMARK 465 LEU A 884 REMARK 465 ALA A 885 REMARK 465 VAL A 886 REMARK 465 ALA A 887 REMARK 465 SER A 888 REMARK 465 CYS A 889 REMARK 465 GLN A 890 REMARK 465 ARG A 891 REMARK 465 PRO A 892 REMARK 465 GLU A 893 REMARK 465 GLY A 894 REMARK 465 TYR A 895 REMARK 465 TRP A 896 REMARK 465 SER A 897 REMARK 465 ASP A 898 REMARK 465 CYS A 899 REMARK 465 GLY A 900 REMARK 465 THR A 901 REMARK 465 GLN A 902 REMARK 465 SER A 903 REMARK 465 ALA A 904 REMARK 465 HIS A 905 REMARK 465 SER A 906 REMARK 465 ASP A 907 REMARK 465 TYR A 908 REMARK 465 ALA A 909 REMARK 465 ASP A 910 REMARK 465 GLU A 911 REMARK 465 GLU A 912 REMARK 465 ASP A 913 REMARK 465 SER A 914 REMARK 465 PHE A 915 REMARK 465 VAL A 916 REMARK 465 SER A 917 REMARK 465 ASP A 918 REMARK 465 SER A 919 REMARK 465 SER A 920 REMARK 465 ASP A 921 REMARK 465 GLN A 922 REMARK 465 VAL A 923 REMARK 465 GLN A 924 REMARK 465 ALA A 925 REMARK 465 CYS A 926 REMARK 465 GLY A 927 REMARK 465 ARG A 928 REMARK 465 ALA A 929 REMARK 465 CYS A 930 REMARK 465 PHE A 931 REMARK 465 TYR A 932 REMARK 465 GLN A 933 REMARK 465 SER A 934 REMARK 465 ARG A 935 REMARK 465 GLY A 936 REMARK 465 PHE A 937 REMARK 465 PRO A 938 REMARK 465 LEU A 939 REMARK 465 VAL A 940 REMARK 465 ARG A 941 REMARK 465 TYR A 942 REMARK 465 ALA A 943 REMARK 465 TYR A 944 REMARK 465 ASN A 945 REMARK 465 LEU A 946 REMARK 465 PRO A 947 REMARK 465 ARG A 948 REMARK 465 VAL A 949 REMARK 465 LYS A 950 REMARK 465 ASP A 951 REMARK 465 MET E 1 REMARK 465 LYS E 2 REMARK 465 LYS E 3 REMARK 465 ILE E 4 REMARK 465 TRP E 5 REMARK 465 LEU E 6 REMARK 465 ALA E 7 REMARK 465 LEU E 8 REMARK 465 ALA E 9 REMARK 465 GLY E 10 REMARK 465 LEU E 11 REMARK 465 VAL E 12 REMARK 465 LEU E 13 REMARK 465 ALA E 14 REMARK 465 PHE E 15 REMARK 465 SER E 16 REMARK 465 ALA E 17 REMARK 465 SER E 18 REMARK 465 ALA E 19 REMARK 465 GLN E 20 REMARK 465 GLY E 27 REMARK 465 GLY E 28 REMARK 465 GLY E 29 REMARK 465 LEU E 30 REMARK 465 VAL E 31 REMARK 465 GLN E 32 REMARK 465 THR E 33 REMARK 465 LYS E 34 REMARK 465 THR E 35 REMARK 465 THR E 36 REMARK 465 THR E 37 REMARK 465 SER E 38 REMARK 465 VAL E 39 REMARK 465 ILE E 40 REMARK 465 ASP E 41 REMARK 465 THR E 42 REMARK 465 THR E 43 REMARK 465 ASN E 44 REMARK 465 ASP E 45 REMARK 465 ALA E 46 REMARK 465 GLN E 47 REMARK 465 ASN E 48 REMARK 465 LEU E 49 REMARK 465 LEU E 50 REMARK 465 THR E 51 REMARK 465 GLN E 52 REMARK 465 ALA E 53 REMARK 465 GLN E 54 REMARK 465 THR E 55 REMARK 465 ILE E 56 REMARK 465 VAL E 57 REMARK 465 ASN E 58 REMARK 465 THR E 59 REMARK 465 LEU E 60 REMARK 465 LYS E 61 REMARK 465 ASP E 62 REMARK 465 TYR E 63 REMARK 465 CYS E 64 REMARK 465 PRO E 65 REMARK 465 ILE E 66 REMARK 465 LEU E 67 REMARK 465 ILE E 68 REMARK 465 ALA E 69 REMARK 465 LYS E 70 REMARK 465 SER E 71 REMARK 465 SER E 72 REMARK 465 SER E 73 REMARK 465 SER E 74 REMARK 465 ASN E 75 REMARK 465 GLY E 76 REMARK 465 GLY E 77 REMARK 465 THR E 78 REMARK 465 ASN E 79 REMARK 465 ASN E 80 REMARK 465 ALA E 81 REMARK 465 ASN E 82 REMARK 465 THR E 83 REMARK 465 PRO E 84 REMARK 465 SER E 85 REMARK 465 TRP E 86 REMARK 465 GLN E 87 REMARK 465 THR E 88 REMARK 465 ALA E 89 REMARK 465 GLY E 90 REMARK 465 GLY E 91 REMARK 465 GLY E 92 REMARK 465 LYS E 93 REMARK 465 ASN E 94 REMARK 465 SER E 95 REMARK 465 CYS E 96 REMARK 465 ALA E 97 REMARK 465 THR E 98 REMARK 465 PHE E 99 REMARK 465 GLY E 100 REMARK 465 ALA E 101 REMARK 465 GLU E 102 REMARK 465 PHE E 103 REMARK 465 SER E 104 REMARK 465 ALA E 105 REMARK 465 ALA E 106 REMARK 465 SER E 107 REMARK 465 ASP E 108 REMARK 465 MET E 109 REMARK 465 ILE E 110 REMARK 465 ASN E 111 REMARK 465 ASN E 112 REMARK 465 ALA E 113 REMARK 465 GLN E 114 REMARK 465 LYS E 115 REMARK 465 ILE E 116 REMARK 465 VAL E 117 REMARK 465 GLN E 118 REMARK 465 GLU E 119 REMARK 465 THR E 120 REMARK 465 GLN E 121 REMARK 465 GLN E 122 REMARK 465 LEU E 123 REMARK 465 SER E 124 REMARK 465 ALA E 125 REMARK 465 ASN E 126 REMARK 465 GLN E 127 REMARK 465 PRO E 128 REMARK 465 LYS E 129 REMARK 465 ASN E 130 REMARK 465 ILE E 131 REMARK 465 THR E 132 REMARK 465 GLN E 133 REMARK 465 PRO E 134 REMARK 465 HIS E 135 REMARK 465 ASN E 136 REMARK 465 LEU E 137 REMARK 465 ASN E 138 REMARK 465 LEU E 139 REMARK 465 ASN E 140 REMARK 465 SER E 141 REMARK 465 PRO E 142 REMARK 465 SER E 143 REMARK 465 SER E 144 REMARK 465 LEU E 145 REMARK 465 THR E 146 REMARK 465 ALA E 147 REMARK 465 LEU E 148 REMARK 465 ALA E 149 REMARK 465 GLN E 150 REMARK 465 LYS E 151 REMARK 465 MET E 152 REMARK 465 LEU E 153 REMARK 465 LYS E 154 REMARK 465 ASN E 155 REMARK 465 ALA E 156 REMARK 465 GLN E 157 REMARK 465 SER E 158 REMARK 465 GLN E 159 REMARK 465 ALA E 160 REMARK 465 GLU E 161 REMARK 465 ILE E 162 REMARK 465 LEU E 163 REMARK 465 LYS E 164 REMARK 465 LEU E 165 REMARK 465 ALA E 166 REMARK 465 ASN E 167 REMARK 465 GLN E 168 REMARK 465 VAL E 169 REMARK 465 GLU E 170 REMARK 465 SER E 171 REMARK 465 ASP E 172 REMARK 465 PHE E 173 REMARK 465 ASN E 174 REMARK 465 LYS E 175 REMARK 465 LEU E 176 REMARK 465 SER E 177 REMARK 465 SER E 178 REMARK 465 GLY E 179 REMARK 465 HIS E 180 REMARK 465 LEU E 181 REMARK 465 LYS E 182 REMARK 465 ASP E 183 REMARK 465 TYR E 184 REMARK 465 ILE E 185 REMARK 465 GLY E 186 REMARK 465 LYS E 187 REMARK 465 CYS E 188 REMARK 465 ASP E 189 REMARK 465 ALA E 190 REMARK 465 SER E 191 REMARK 465 ALA E 192 REMARK 465 ILE E 193 REMARK 465 SER E 194 REMARK 465 SER E 195 REMARK 465 ALA E 196 REMARK 465 ASN E 197 REMARK 465 MET E 198 REMARK 465 THR E 199 REMARK 465 MET E 200 REMARK 465 GLN E 201 REMARK 465 ASN E 202 REMARK 465 GLN E 203 REMARK 465 LYS E 204 REMARK 465 ASN E 205 REMARK 465 ASN E 206 REMARK 465 TRP E 207 REMARK 465 GLY E 208 REMARK 465 ASN E 209 REMARK 465 GLY E 210 REMARK 465 CYS E 211 REMARK 465 ALA E 212 REMARK 465 GLY E 213 REMARK 465 VAL E 214 REMARK 465 GLU E 215 REMARK 465 GLU E 216 REMARK 465 THR E 217 REMARK 465 GLN E 218 REMARK 465 SER E 219 REMARK 465 LEU E 220 REMARK 465 LEU E 221 REMARK 465 LYS E 222 REMARK 465 THR E 223 REMARK 465 SER E 224 REMARK 465 ALA E 225 REMARK 465 ALA E 226 REMARK 465 ASP E 227 REMARK 465 PHE E 228 REMARK 465 ASN E 229 REMARK 465 ASN E 230 REMARK 465 GLN E 231 REMARK 465 THR E 232 REMARK 465 PRO E 233 REMARK 465 GLN E 234 REMARK 465 ILE E 235 REMARK 465 ASN E 236 REMARK 465 GLN E 237 REMARK 465 ALA E 238 REMARK 465 GLN E 239 REMARK 465 ASN E 240 REMARK 465 LEU E 241 REMARK 465 ALA E 242 REMARK 465 ASN E 243 REMARK 465 THR E 244 REMARK 465 LEU E 245 REMARK 465 ILE E 246 REMARK 465 GLN E 247 REMARK 465 GLU E 248 REMARK 465 LEU E 249 REMARK 465 GLY E 250 REMARK 465 ASN E 251 REMARK 465 ASN E 252 REMARK 465 PRO E 253 REMARK 465 PHE E 254 REMARK 465 ARG E 255 REMARK 465 ALA E 256 REMARK 465 SER E 257 REMARK 465 GLY E 258 REMARK 465 GLY E 259 REMARK 465 GLY E 260 REMARK 465 SER E 261 REMARK 465 GLY E 262 REMARK 465 GLY E 263 REMARK 465 GLY E 264 REMARK 465 GLY E 265 REMARK 465 SER E 266 REMARK 465 GLY E 267 REMARK 465 LYS E 268 REMARK 465 LEU E 269 REMARK 465 SER E 270 REMARK 465 ASP E 271 REMARK 465 THR E 272 REMARK 465 TYR E 273 REMARK 465 GLU E 274 REMARK 465 GLN E 275 REMARK 465 LEU E 276 REMARK 465 SER E 277 REMARK 465 ARG E 278 REMARK 465 LEU E 279 REMARK 465 LEU E 280 REMARK 465 THR E 281 REMARK 465 ASN E 282 REMARK 465 ASP E 283 REMARK 465 ASN E 284 REMARK 465 GLY E 285 REMARK 465 THR E 286 REMARK 465 ASN E 287 REMARK 465 SER E 288 REMARK 465 LYS E 289 REMARK 465 THR E 290 REMARK 465 SER E 291 REMARK 465 ALA E 292 REMARK 465 GLN E 293 REMARK 465 ALA E 294 REMARK 465 ILE E 295 REMARK 465 ASN E 296 REMARK 465 GLN E 297 REMARK 465 ALA E 298 REMARK 465 VAL E 299 REMARK 465 ASN E 300 REMARK 465 ASN E 301 REMARK 465 LEU E 302 REMARK 465 ASN E 303 REMARK 465 GLU E 304 REMARK 465 ARG E 305 REMARK 465 ALA E 306 REMARK 465 LYS E 307 REMARK 465 THR E 308 REMARK 465 LEU E 309 REMARK 465 ALA E 310 REMARK 465 GLY E 311 REMARK 465 GLY E 312 REMARK 465 THR E 313 REMARK 465 THR E 314 REMARK 465 ASN E 315 REMARK 465 SER E 316 REMARK 465 PRO E 317 REMARK 465 ALA E 318 REMARK 465 TYR E 319 REMARK 465 GLN E 320 REMARK 465 ALA E 321 REMARK 465 THR E 322 REMARK 465 LEU E 323 REMARK 465 LEU E 324 REMARK 465 ALA E 325 REMARK 465 LEU E 326 REMARK 465 ARG E 327 REMARK 465 SER E 328 REMARK 465 VAL E 329 REMARK 465 LEU E 330 REMARK 465 GLY E 331 REMARK 465 LEU E 332 REMARK 465 TRP E 333 REMARK 465 ASN E 334 REMARK 465 SER E 335 REMARK 465 MET E 336 REMARK 465 GLY E 337 REMARK 465 TYR E 338 REMARK 465 ALA E 339 REMARK 465 VAL E 340 REMARK 465 ILE E 341 REMARK 465 CYS E 342 REMARK 465 GLY E 343 REMARK 465 GLY E 344 REMARK 465 TYR E 345 REMARK 465 THR E 346 REMARK 465 LYS E 347 REMARK 465 SER E 348 REMARK 465 PRO E 349 REMARK 465 GLY E 350 REMARK 465 GLU E 351 REMARK 465 ASN E 352 REMARK 465 ASN E 353 REMARK 465 GLN E 354 REMARK 465 LYS E 355 REMARK 465 ASP E 356 REMARK 465 PHE E 357 REMARK 465 HIS E 358 REMARK 465 TYR E 359 REMARK 465 THR E 360 REMARK 465 ASP E 361 REMARK 465 GLU E 362 REMARK 465 ASN E 363 REMARK 465 GLY E 364 REMARK 465 ASN E 365 REMARK 465 GLY E 366 REMARK 465 THR E 367 REMARK 465 THR E 368 REMARK 465 ILE E 369 REMARK 465 ASN E 370 REMARK 465 CYS E 371 REMARK 465 GLY E 372 REMARK 465 GLY E 373 REMARK 465 SER E 374 REMARK 465 THR E 375 REMARK 465 ASN E 376 REMARK 465 SER E 377 REMARK 465 ASN E 378 REMARK 465 GLY E 379 REMARK 465 THR E 380 REMARK 465 HIS E 381 REMARK 465 SER E 382 REMARK 465 TYR E 383 REMARK 465 ASN E 384 REMARK 465 GLY E 385 REMARK 465 THR E 386 REMARK 465 ASN E 387 REMARK 465 THR E 388 REMARK 465 LEU E 389 REMARK 465 LYS E 390 REMARK 465 ALA E 391 REMARK 465 ASP E 392 REMARK 465 LYS E 393 REMARK 465 ASN E 394 REMARK 465 VAL E 395 REMARK 465 SER E 396 REMARK 465 LEU E 397 REMARK 465 SER E 398 REMARK 465 ILE E 399 REMARK 465 GLU E 400 REMARK 465 GLN E 401 REMARK 465 TYR E 402 REMARK 465 GLU E 403 REMARK 465 LYS E 404 REMARK 465 ILE E 405 REMARK 465 HIS E 406 REMARK 465 GLU E 407 REMARK 465 ALA E 408 REMARK 465 TYR E 409 REMARK 465 GLN E 410 REMARK 465 ILE E 411 REMARK 465 LEU E 412 REMARK 465 SER E 413 REMARK 465 LYS E 414 REMARK 465 ALA E 415 REMARK 465 LEU E 416 REMARK 465 LYS E 417 REMARK 465 GLN E 418 REMARK 465 ALA E 419 REMARK 465 GLY E 420 REMARK 465 LEU E 421 REMARK 465 ALA E 422 REMARK 465 PRO E 423 REMARK 465 LEU E 424 REMARK 465 ASN E 425 REMARK 465 SER E 426 REMARK 465 LYS E 427 REMARK 465 GLY E 428 REMARK 465 GLU E 429 REMARK 465 LYS E 430 REMARK 465 LEU E 431 REMARK 465 GLU E 432 REMARK 465 ALA E 433 REMARK 465 HIS E 434 REMARK 465 VAL E 435 REMARK 465 THR E 436 REMARK 465 THR E 437 REMARK 465 SER E 438 REMARK 465 LYS E 439 REMARK 465 TYR E 440 REMARK 465 GLY E 441 REMARK 465 SER E 550 REMARK 465 HIS E 551 REMARK 465 HIS E 552 REMARK 465 HIS E 553 REMARK 465 HIS E 554 REMARK 465 HIS E 555 REMARK 465 HIS E 556 REMARK 465 GLU E 557 REMARK 465 PRO E 558 REMARK 465 GLU E 559 REMARK 465 ALA E 560 REMARK 465 MET C 1 REMARK 465 ARG C 2 REMARK 465 PRO C 3 REMARK 465 ARG C 4 REMARK 465 SER C 5 REMARK 465 GLY C 6 REMARK 465 GLY C 7 REMARK 465 ARG C 8 REMARK 465 PRO C 9 REMARK 465 GLY C 10 REMARK 465 ALA C 11 REMARK 465 THR C 12 REMARK 465 GLY C 13 REMARK 465 ARG C 14 REMARK 465 ARG C 15 REMARK 465 ARG C 16 REMARK 465 ARG C 17 REMARK 465 ARG C 18 REMARK 465 LEU C 19 REMARK 465 ARG C 20 REMARK 465 ARG C 21 REMARK 465 ARG C 22 REMARK 465 PRO C 23 REMARK 465 ARG C 24 REMARK 465 GLY C 25 REMARK 465 LEU C 26 REMARK 465 ARG C 27 REMARK 465 CYS C 28 REMARK 465 SER C 29 REMARK 465 ARG C 30 REMARK 465 LEU C 31 REMARK 465 PRO C 32 REMARK 465 PRO C 33 REMARK 465 PRO C 34 REMARK 465 PRO C 35 REMARK 465 PRO C 36 REMARK 465 LEU C 37 REMARK 465 PRO C 38 REMARK 465 LEU C 39 REMARK 465 LEU C 40 REMARK 465 LEU C 41 REMARK 465 GLY C 42 REMARK 465 LEU C 43 REMARK 465 LEU C 44 REMARK 465 LEU C 45 REMARK 465 ALA C 46 REMARK 465 ALA C 47 REMARK 465 ALA C 48 REMARK 465 GLY C 49 REMARK 465 PRO C 50 REMARK 465 GLY C 51 REMARK 465 ALA C 52 REMARK 465 ALA C 53 REMARK 465 ARG C 54 REMARK 465 ALA C 55 REMARK 465 ARG C 208 REMARK 465 PRO C 209 REMARK 465 PRO C 210 REMARK 465 ARG C 211 REMARK 465 LYS C 241 REMARK 465 LEU C 242 REMARK 465 LYS C 243 REMARK 465 GLN C 244 REMARK 465 ARG C 245 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 GLN C 248 REMARK 465 ASN C 249 REMARK 465 SER C 250 REMARK 465 MET C 251 REMARK 465 ASN C 252 REMARK 465 ARG C 253 REMARK 465 LEU C 254 REMARK 465 ALA C 255 REMARK 465 VAL C 256 REMARK 465 GLN C 257 REMARK 465 ALA C 258 REMARK 465 LEU C 259 REMARK 465 GLU C 260 REMARK 465 LYS C 261 REMARK 465 MET C 262 REMARK 465 GLU C 263 REMARK 465 THR C 264 REMARK 465 ARG C 265 REMARK 465 LYS C 266 REMARK 465 PHE C 267 REMARK 465 ASN C 268 REMARK 465 SER C 269 REMARK 465 LYS C 270 REMARK 465 SER C 271 REMARK 465 LYS C 272 REMARK 465 GLY C 273 REMARK 465 ARG C 274 REMARK 465 ARG C 275 REMARK 465 GLU C 276 REMARK 465 GLY C 277 REMARK 465 SER C 278 REMARK 465 CYS C 279 REMARK 465 GLY C 280 REMARK 465 ALA C 281 REMARK 465 LEU C 282 REMARK 465 ASP C 283 REMARK 465 THR C 284 REMARK 465 LEU C 285 REMARK 465 SER C 286 REMARK 465 SER C 287 REMARK 465 SER C 288 REMARK 465 SER C 289 REMARK 465 THR C 290 REMARK 465 SER C 291 REMARK 465 ASP C 292 REMARK 465 CYS C 293 REMARK 465 ALA C 294 REMARK 465 ILE C 295 REMARK 465 CYS C 296 REMARK 465 LEU C 297 REMARK 465 GLU C 298 REMARK 465 LYS C 299 REMARK 465 TYR C 300 REMARK 465 ILE C 301 REMARK 465 ASP C 302 REMARK 465 GLY C 303 REMARK 465 GLU C 304 REMARK 465 GLU C 305 REMARK 465 LEU C 306 REMARK 465 ARG C 307 REMARK 465 VAL C 308 REMARK 465 ILE C 309 REMARK 465 PRO C 310 REMARK 465 CYS C 311 REMARK 465 THR C 312 REMARK 465 HIS C 313 REMARK 465 ARG C 314 REMARK 465 PHE C 315 REMARK 465 HIS C 316 REMARK 465 ARG C 317 REMARK 465 LYS C 318 REMARK 465 CYS C 319 REMARK 465 VAL C 320 REMARK 465 ASP C 321 REMARK 465 PRO C 322 REMARK 465 TRP C 323 REMARK 465 LEU C 324 REMARK 465 LEU C 325 REMARK 465 GLN C 326 REMARK 465 HIS C 327 REMARK 465 HIS C 328 REMARK 465 THR C 329 REMARK 465 CYS C 330 REMARK 465 PRO C 331 REMARK 465 HIS C 332 REMARK 465 CYS C 333 REMARK 465 ARG C 334 REMARK 465 HIS C 335 REMARK 465 ASN C 336 REMARK 465 ILE C 337 REMARK 465 ILE C 338 REMARK 465 GLU C 339 REMARK 465 GLN C 340 REMARK 465 LYS C 341 REMARK 465 GLY C 342 REMARK 465 ASN C 343 REMARK 465 PRO C 344 REMARK 465 SER C 345 REMARK 465 ALA C 346 REMARK 465 VAL C 347 REMARK 465 CYS C 348 REMARK 465 VAL C 349 REMARK 465 GLU C 350 REMARK 465 THR C 351 REMARK 465 SER C 352 REMARK 465 ASN C 353 REMARK 465 LEU C 354 REMARK 465 SER C 355 REMARK 465 ARG C 356 REMARK 465 GLY C 357 REMARK 465 ARG C 358 REMARK 465 GLN C 359 REMARK 465 GLN C 360 REMARK 465 ARG C 361 REMARK 465 VAL C 362 REMARK 465 THR C 363 REMARK 465 LEU C 364 REMARK 465 PRO C 365 REMARK 465 VAL C 366 REMARK 465 HIS C 367 REMARK 465 TYR C 368 REMARK 465 PRO C 369 REMARK 465 GLY C 370 REMARK 465 ARG C 371 REMARK 465 VAL C 372 REMARK 465 HIS C 373 REMARK 465 ARG C 374 REMARK 465 THR C 375 REMARK 465 ASN C 376 REMARK 465 ALA C 377 REMARK 465 ILE C 378 REMARK 465 PRO C 379 REMARK 465 ALA C 380 REMARK 465 TYR C 381 REMARK 465 PRO C 382 REMARK 465 THR C 383 REMARK 465 ARG C 384 REMARK 465 THR C 385 REMARK 465 SER C 386 REMARK 465 MET C 387 REMARK 465 ASP C 388 REMARK 465 SER C 389 REMARK 465 HIS C 390 REMARK 465 GLY C 391 REMARK 465 ASN C 392 REMARK 465 PRO C 393 REMARK 465 VAL C 394 REMARK 465 THR C 395 REMARK 465 LEU C 396 REMARK 465 LEU C 397 REMARK 465 THR C 398 REMARK 465 MET C 399 REMARK 465 ASP C 400 REMARK 465 ARG C 401 REMARK 465 HIS C 402 REMARK 465 GLY C 403 REMARK 465 GLU C 404 REMARK 465 GLN C 405 REMARK 465 SER C 406 REMARK 465 LEU C 407 REMARK 465 TYR C 408 REMARK 465 SER C 409 REMARK 465 PRO C 410 REMARK 465 GLN C 411 REMARK 465 THR C 412 REMARK 465 PRO C 413 REMARK 465 ALA C 414 REMARK 465 TYR C 415 REMARK 465 ILE C 416 REMARK 465 ARG C 417 REMARK 465 SER C 418 REMARK 465 TYR C 419 REMARK 465 PRO C 420 REMARK 465 PRO C 421 REMARK 465 LEU C 422 REMARK 465 HIS C 423 REMARK 465 LEU C 424 REMARK 465 ASP C 425 REMARK 465 HIS C 426 REMARK 465 SER C 427 REMARK 465 LEU C 428 REMARK 465 ALA C 429 REMARK 465 ALA C 430 REMARK 465 HIS C 431 REMARK 465 ARG C 432 REMARK 465 CYS C 433 REMARK 465 GLY C 434 REMARK 465 LEU C 435 REMARK 465 GLU C 436 REMARK 465 HIS C 437 REMARK 465 ARG C 438 REMARK 465 ALA C 439 REMARK 465 TYR C 440 REMARK 465 SER C 441 REMARK 465 PRO C 442 REMARK 465 ALA C 443 REMARK 465 HIS C 444 REMARK 465 PRO C 445 REMARK 465 PHE C 446 REMARK 465 ARG C 447 REMARK 465 ARG C 448 REMARK 465 PRO C 449 REMARK 465 LYS C 450 REMARK 465 LEU C 451 REMARK 465 SER C 452 REMARK 465 GLY C 453 REMARK 465 ARG C 454 REMARK 465 SER C 455 REMARK 465 PHE C 456 REMARK 465 SER C 457 REMARK 465 LYS C 458 REMARK 465 ALA C 459 REMARK 465 ALA C 460 REMARK 465 CYS C 461 REMARK 465 PHE C 462 REMARK 465 SER C 463 REMARK 465 GLN C 464 REMARK 465 TYR C 465 REMARK 465 GLU C 466 REMARK 465 THR C 467 REMARK 465 MET C 468 REMARK 465 TYR C 469 REMARK 465 GLN C 470 REMARK 465 HIS C 471 REMARK 465 TYR C 472 REMARK 465 TYR C 473 REMARK 465 PHE C 474 REMARK 465 GLN C 475 REMARK 465 GLY C 476 REMARK 465 LEU C 477 REMARK 465 SER C 478 REMARK 465 TYR C 479 REMARK 465 PRO C 480 REMARK 465 GLU C 481 REMARK 465 GLN C 482 REMARK 465 GLU C 483 REMARK 465 GLY C 484 REMARK 465 GLN C 485 REMARK 465 SER C 486 REMARK 465 PRO C 487 REMARK 465 PRO C 488 REMARK 465 SER C 489 REMARK 465 LEU C 490 REMARK 465 ALA C 491 REMARK 465 PRO C 492 REMARK 465 ARG C 493 REMARK 465 GLY C 494 REMARK 465 PRO C 495 REMARK 465 ALA C 496 REMARK 465 ARG C 497 REMARK 465 ALA C 498 REMARK 465 PHE C 499 REMARK 465 PRO C 500 REMARK 465 PRO C 501 REMARK 465 SER C 502 REMARK 465 GLY C 503 REMARK 465 SER C 504 REMARK 465 GLY C 505 REMARK 465 SER C 506 REMARK 465 LEU C 507 REMARK 465 LEU C 508 REMARK 465 PHE C 509 REMARK 465 PRO C 510 REMARK 465 THR C 511 REMARK 465 VAL C 512 REMARK 465 VAL C 513 REMARK 465 HIS C 514 REMARK 465 VAL C 515 REMARK 465 ALA C 516 REMARK 465 PRO C 517 REMARK 465 PRO C 518 REMARK 465 SER C 519 REMARK 465 HIS C 520 REMARK 465 LEU C 521 REMARK 465 GLU C 522 REMARK 465 SER C 523 REMARK 465 GLY C 524 REMARK 465 SER C 525 REMARK 465 THR C 526 REMARK 465 SER C 527 REMARK 465 SER C 528 REMARK 465 PHE C 529 REMARK 465 SER C 530 REMARK 465 CYS C 531 REMARK 465 TYR C 532 REMARK 465 HIS C 533 REMARK 465 GLY C 534 REMARK 465 HIS C 535 REMARK 465 ARG C 536 REMARK 465 SER C 537 REMARK 465 VAL C 538 REMARK 465 CYS C 539 REMARK 465 SER C 540 REMARK 465 GLY C 541 REMARK 465 TYR C 542 REMARK 465 LEU C 543 REMARK 465 ALA C 544 REMARK 465 ASP C 545 REMARK 465 CYS C 546 REMARK 465 PRO C 547 REMARK 465 GLY C 548 REMARK 465 SER C 549 REMARK 465 ASP C 550 REMARK 465 SER C 551 REMARK 465 SER C 552 REMARK 465 SER C 553 REMARK 465 SER C 554 REMARK 465 SER C 555 REMARK 465 SER C 556 REMARK 465 SER C 557 REMARK 465 GLY C 558 REMARK 465 GLN C 559 REMARK 465 CYS C 560 REMARK 465 HIS C 561 REMARK 465 CYS C 562 REMARK 465 SER C 563 REMARK 465 SER C 564 REMARK 465 SER C 565 REMARK 465 ASP C 566 REMARK 465 SER C 567 REMARK 465 VAL C 568 REMARK 465 VAL C 569 REMARK 465 ASP C 570 REMARK 465 CYS C 571 REMARK 465 THR C 572 REMARK 465 GLU C 573 REMARK 465 VAL C 574 REMARK 465 SER C 575 REMARK 465 ASN C 576 REMARK 465 GLN C 577 REMARK 465 GLY C 578 REMARK 465 VAL C 579 REMARK 465 TYR C 580 REMARK 465 GLY C 581 REMARK 465 SER C 582 REMARK 465 CYS C 583 REMARK 465 SER C 584 REMARK 465 THR C 585 REMARK 465 PHE C 586 REMARK 465 ARG C 587 REMARK 465 SER C 588 REMARK 465 SER C 589 REMARK 465 LEU C 590 REMARK 465 SER C 591 REMARK 465 SER C 592 REMARK 465 ASP C 593 REMARK 465 TYR C 594 REMARK 465 ASP C 595 REMARK 465 PRO C 596 REMARK 465 PHE C 597 REMARK 465 ILE C 598 REMARK 465 TYR C 599 REMARK 465 ARG C 600 REMARK 465 SER C 601 REMARK 465 ARG C 602 REMARK 465 SER C 603 REMARK 465 PRO C 604 REMARK 465 CYS C 605 REMARK 465 ARG C 606 REMARK 465 ALA C 607 REMARK 465 SER C 608 REMARK 465 GLU C 609 REMARK 465 ALA C 610 REMARK 465 GLY C 611 REMARK 465 GLY C 612 REMARK 465 SER C 613 REMARK 465 GLY C 614 REMARK 465 SER C 615 REMARK 465 SER C 616 REMARK 465 GLY C 617 REMARK 465 ARG C 618 REMARK 465 GLY C 619 REMARK 465 PRO C 620 REMARK 465 ALA C 621 REMARK 465 LEU C 622 REMARK 465 CYS C 623 REMARK 465 PHE C 624 REMARK 465 GLU C 625 REMARK 465 GLY C 626 REMARK 465 SER C 627 REMARK 465 PRO C 628 REMARK 465 PRO C 629 REMARK 465 PRO C 630 REMARK 465 GLU C 631 REMARK 465 GLU C 632 REMARK 465 LEU C 633 REMARK 465 PRO C 634 REMARK 465 ALA C 635 REMARK 465 VAL C 636 REMARK 465 HIS C 637 REMARK 465 SER C 638 REMARK 465 HIS C 639 REMARK 465 GLY C 640 REMARK 465 ALA C 641 REMARK 465 GLY C 642 REMARK 465 ARG C 643 REMARK 465 GLY C 644 REMARK 465 GLU C 645 REMARK 465 PRO C 646 REMARK 465 TRP C 647 REMARK 465 PRO C 648 REMARK 465 GLY C 649 REMARK 465 PRO C 650 REMARK 465 ALA C 651 REMARK 465 SER C 652 REMARK 465 PRO C 653 REMARK 465 SER C 654 REMARK 465 GLY C 655 REMARK 465 ASP C 656 REMARK 465 GLN C 657 REMARK 465 VAL C 658 REMARK 465 SER C 659 REMARK 465 THR C 660 REMARK 465 CYS C 661 REMARK 465 SER C 662 REMARK 465 LEU C 663 REMARK 465 GLU C 664 REMARK 465 MET C 665 REMARK 465 ASN C 666 REMARK 465 TYR C 667 REMARK 465 SER C 668 REMARK 465 SER C 669 REMARK 465 ASN C 670 REMARK 465 SER C 671 REMARK 465 SER C 672 REMARK 465 LEU C 673 REMARK 465 GLU C 674 REMARK 465 HIS C 675 REMARK 465 ARG C 676 REMARK 465 GLY C 677 REMARK 465 PRO C 678 REMARK 465 ASN C 679 REMARK 465 SER C 680 REMARK 465 SER C 681 REMARK 465 THR C 682 REMARK 465 SER C 683 REMARK 465 GLU C 684 REMARK 465 VAL C 685 REMARK 465 GLY C 686 REMARK 465 LEU C 687 REMARK 465 GLU C 688 REMARK 465 ALA C 689 REMARK 465 SER C 690 REMARK 465 PRO C 691 REMARK 465 GLY C 692 REMARK 465 ALA C 693 REMARK 465 ALA C 694 REMARK 465 PRO C 695 REMARK 465 ASP C 696 REMARK 465 LEU C 697 REMARK 465 ARG C 698 REMARK 465 ARG C 699 REMARK 465 THR C 700 REMARK 465 TRP C 701 REMARK 465 LYS C 702 REMARK 465 GLY C 703 REMARK 465 GLY C 704 REMARK 465 HIS C 705 REMARK 465 GLU C 706 REMARK 465 LEU C 707 REMARK 465 PRO C 708 REMARK 465 SER C 709 REMARK 465 CYS C 710 REMARK 465 ALA C 711 REMARK 465 CYS C 712 REMARK 465 CYS C 713 REMARK 465 CYS C 714 REMARK 465 GLU C 715 REMARK 465 PRO C 716 REMARK 465 GLN C 717 REMARK 465 PRO C 718 REMARK 465 SER C 719 REMARK 465 PRO C 720 REMARK 465 ALA C 721 REMARK 465 GLY C 722 REMARK 465 PRO C 723 REMARK 465 SER C 724 REMARK 465 ALA C 725 REMARK 465 GLY C 726 REMARK 465 ALA C 727 REMARK 465 ALA C 728 REMARK 465 GLY C 729 REMARK 465 SER C 730 REMARK 465 SER C 731 REMARK 465 THR C 732 REMARK 465 LEU C 733 REMARK 465 PHE C 734 REMARK 465 LEU C 735 REMARK 465 GLY C 736 REMARK 465 PRO C 737 REMARK 465 HIS C 738 REMARK 465 LEU C 739 REMARK 465 TYR C 740 REMARK 465 GLU C 741 REMARK 465 GLY C 742 REMARK 465 SER C 743 REMARK 465 GLY C 744 REMARK 465 PRO C 745 REMARK 465 ALA C 746 REMARK 465 GLY C 747 REMARK 465 GLY C 748 REMARK 465 GLU C 749 REMARK 465 PRO C 750 REMARK 465 GLN C 751 REMARK 465 SER C 752 REMARK 465 GLY C 753 REMARK 465 SER C 754 REMARK 465 SER C 755 REMARK 465 GLN C 756 REMARK 465 GLY C 757 REMARK 465 LEU C 758 REMARK 465 TYR C 759 REMARK 465 GLY C 760 REMARK 465 LEU C 761 REMARK 465 HIS C 762 REMARK 465 PRO C 763 REMARK 465 ASP C 764 REMARK 465 HIS C 765 REMARK 465 LEU C 766 REMARK 465 PRO C 767 REMARK 465 ARG C 768 REMARK 465 THR C 769 REMARK 465 ASP C 770 REMARK 465 GLY C 771 REMARK 465 VAL C 772 REMARK 465 LYS C 773 REMARK 465 TYR C 774 REMARK 465 GLU C 775 REMARK 465 GLY C 776 REMARK 465 LEU C 777 REMARK 465 PRO C 778 REMARK 465 CYS C 779 REMARK 465 CYS C 780 REMARK 465 PHE C 781 REMARK 465 TYR C 782 REMARK 465 GLU C 783 REMARK 465 GLU C 784 REMARK 465 LYS C 785 REMARK 465 GLN C 786 REMARK 465 VAL C 787 REMARK 465 ALA C 788 REMARK 465 ARG C 789 REMARK 465 GLY C 790 REMARK 465 GLY C 791 REMARK 465 GLY C 792 REMARK 465 GLY C 793 REMARK 465 GLY C 794 REMARK 465 SER C 795 REMARK 465 GLY C 796 REMARK 465 CYS C 797 REMARK 465 TYR C 798 REMARK 465 THR C 799 REMARK 465 GLU C 800 REMARK 465 ASP C 801 REMARK 465 TYR C 802 REMARK 465 SER C 803 REMARK 465 VAL C 804 REMARK 465 SER C 805 REMARK 465 VAL C 806 REMARK 465 GLN C 807 REMARK 465 TYR C 808 REMARK 465 THR C 809 REMARK 465 LEU C 810 REMARK 465 THR C 811 REMARK 465 GLU C 812 REMARK 465 GLU C 813 REMARK 465 PRO C 814 REMARK 465 PRO C 815 REMARK 465 PRO C 816 REMARK 465 GLY C 817 REMARK 465 CYS C 818 REMARK 465 TYR C 819 REMARK 465 PRO C 820 REMARK 465 GLY C 821 REMARK 465 ALA C 822 REMARK 465 ARG C 823 REMARK 465 ASP C 824 REMARK 465 LEU C 825 REMARK 465 SER C 826 REMARK 465 GLN C 827 REMARK 465 ARG C 828 REMARK 465 ILE C 829 REMARK 465 PRO C 830 REMARK 465 ILE C 831 REMARK 465 ILE C 832 REMARK 465 PRO C 833 REMARK 465 GLU C 834 REMARK 465 ASP C 835 REMARK 465 VAL C 836 REMARK 465 ASP C 837 REMARK 465 CYS C 838 REMARK 465 ASP C 839 REMARK 465 LEU C 840 REMARK 465 GLY C 841 REMARK 465 LEU C 842 REMARK 465 PRO C 843 REMARK 465 SER C 844 REMARK 465 ASP C 845 REMARK 465 CYS C 846 REMARK 465 GLN C 847 REMARK 465 GLY C 848 REMARK 465 THR C 849 REMARK 465 HIS C 850 REMARK 465 SER C 851 REMARK 465 LEU C 852 REMARK 465 GLY C 853 REMARK 465 SER C 854 REMARK 465 TRP C 855 REMARK 465 GLY C 856 REMARK 465 GLY C 857 REMARK 465 THR C 858 REMARK 465 ARG C 859 REMARK 465 GLY C 860 REMARK 465 PRO C 861 REMARK 465 ASP C 862 REMARK 465 THR C 863 REMARK 465 PRO C 864 REMARK 465 ARG C 865 REMARK 465 PRO C 866 REMARK 465 HIS C 867 REMARK 465 ARG C 868 REMARK 465 GLY C 869 REMARK 465 LEU C 870 REMARK 465 GLY C 871 REMARK 465 ALA C 872 REMARK 465 THR C 873 REMARK 465 ARG C 874 REMARK 465 GLU C 875 REMARK 465 GLU C 876 REMARK 465 GLU C 877 REMARK 465 ARG C 878 REMARK 465 ALA C 879 REMARK 465 LEU C 880 REMARK 465 CYS C 881 REMARK 465 CYS C 882 REMARK 465 GLN C 883 REMARK 465 ALA C 884 REMARK 465 ARG C 885 REMARK 465 ALA C 886 REMARK 465 LEU C 887 REMARK 465 LEU C 888 REMARK 465 ARG C 889 REMARK 465 PRO C 890 REMARK 465 GLY C 891 REMARK 465 CYS C 892 REMARK 465 PRO C 893 REMARK 465 PRO C 894 REMARK 465 GLU C 895 REMARK 465 GLU C 896 REMARK 465 ALA C 897 REMARK 465 GLY C 898 REMARK 465 ALA C 899 REMARK 465 VAL C 900 REMARK 465 ARG C 901 REMARK 465 ALA C 902 REMARK 465 ASN C 903 REMARK 465 PHE C 904 REMARK 465 PRO C 905 REMARK 465 SER C 906 REMARK 465 ALA C 907 REMARK 465 LEU C 908 REMARK 465 GLN C 909 REMARK 465 ASP C 910 REMARK 465 THR C 911 REMARK 465 GLN C 912 REMARK 465 GLU C 913 REMARK 465 SER C 914 REMARK 465 SER C 915 REMARK 465 THR C 916 REMARK 465 THR C 917 REMARK 465 ALA C 918 REMARK 465 THR C 919 REMARK 465 GLU C 920 REMARK 465 ALA C 921 REMARK 465 ALA C 922 REMARK 465 GLY C 923 REMARK 465 PRO C 924 REMARK 465 ARG C 925 REMARK 465 SER C 926 REMARK 465 HIS C 927 REMARK 465 SER C 928 REMARK 465 ALA C 929 REMARK 465 ASP C 930 REMARK 465 SER C 931 REMARK 465 SER C 932 REMARK 465 SER C 933 REMARK 465 PRO C 934 REMARK 465 GLY C 935 REMARK 465 ALA C 936 REMARK 465 ALA G 130 REMARK 465 MET H 1 REMARK 465 ARG H 2 REMARK 465 PRO H 3 REMARK 465 ARG H 4 REMARK 465 SER H 5 REMARK 465 GLY H 6 REMARK 465 GLY H 7 REMARK 465 ARG H 8 REMARK 465 PRO H 9 REMARK 465 GLY H 10 REMARK 465 ALA H 11 REMARK 465 THR H 12 REMARK 465 GLY H 13 REMARK 465 ARG H 14 REMARK 465 ARG H 15 REMARK 465 ARG H 16 REMARK 465 ARG H 17 REMARK 465 ARG H 18 REMARK 465 LEU H 19 REMARK 465 ARG H 20 REMARK 465 ARG H 21 REMARK 465 ARG H 22 REMARK 465 PRO H 23 REMARK 465 ARG H 24 REMARK 465 GLY H 25 REMARK 465 LEU H 26 REMARK 465 ARG H 27 REMARK 465 CYS H 28 REMARK 465 SER H 29 REMARK 465 ARG H 30 REMARK 465 LEU H 31 REMARK 465 PRO H 32 REMARK 465 PRO H 33 REMARK 465 PRO H 34 REMARK 465 PRO H 35 REMARK 465 PRO H 36 REMARK 465 LEU H 37 REMARK 465 PRO H 38 REMARK 465 LEU H 39 REMARK 465 LEU H 40 REMARK 465 LEU H 41 REMARK 465 GLY H 42 REMARK 465 LEU H 43 REMARK 465 LEU H 44 REMARK 465 LEU H 45 REMARK 465 ALA H 46 REMARK 465 ALA H 47 REMARK 465 ALA H 48 REMARK 465 GLY H 49 REMARK 465 PRO H 50 REMARK 465 GLY H 51 REMARK 465 ALA H 52 REMARK 465 ALA H 53 REMARK 465 ARG H 54 REMARK 465 ALA H 55 REMARK 465 ARG H 208 REMARK 465 PRO H 209 REMARK 465 PRO H 210 REMARK 465 ARG H 211 REMARK 465 GLN H 212 REMARK 465 PRO H 213 REMARK 465 THR H 214 REMARK 465 GLU H 215 REMARK 465 TYR H 216 REMARK 465 PHE H 217 REMARK 465 ASP H 218 REMARK 465 MET H 219 REMARK 465 GLY H 220 REMARK 465 ILE H 221 REMARK 465 PHE H 222 REMARK 465 LEU H 223 REMARK 465 ALA H 224 REMARK 465 PHE H 225 REMARK 465 PHE H 226 REMARK 465 VAL H 227 REMARK 465 VAL H 228 REMARK 465 VAL H 229 REMARK 465 SER H 230 REMARK 465 LEU H 231 REMARK 465 VAL H 232 REMARK 465 CYS H 233 REMARK 465 LEU H 234 REMARK 465 ILE H 235 REMARK 465 LEU H 236 REMARK 465 LEU H 237 REMARK 465 VAL H 238 REMARK 465 LYS H 239 REMARK 465 ILE H 240 REMARK 465 LYS H 241 REMARK 465 LEU H 242 REMARK 465 LYS H 243 REMARK 465 GLN H 244 REMARK 465 ARG H 245 REMARK 465 ARG H 246 REMARK 465 SER H 247 REMARK 465 GLN H 248 REMARK 465 ASN H 249 REMARK 465 SER H 250 REMARK 465 MET H 251 REMARK 465 ASN H 252 REMARK 465 ARG H 253 REMARK 465 LEU H 254 REMARK 465 ALA H 255 REMARK 465 VAL H 256 REMARK 465 GLN H 257 REMARK 465 ALA H 258 REMARK 465 LEU H 259 REMARK 465 GLU H 260 REMARK 465 LYS H 261 REMARK 465 MET H 262 REMARK 465 GLU H 263 REMARK 465 THR H 264 REMARK 465 ARG H 265 REMARK 465 LYS H 266 REMARK 465 PHE H 267 REMARK 465 ASN H 268 REMARK 465 SER H 269 REMARK 465 LYS H 270 REMARK 465 SER H 271 REMARK 465 LYS H 272 REMARK 465 GLY H 273 REMARK 465 ARG H 274 REMARK 465 ARG H 275 REMARK 465 GLU H 276 REMARK 465 GLY H 277 REMARK 465 SER H 278 REMARK 465 CYS H 279 REMARK 465 GLY H 280 REMARK 465 ALA H 281 REMARK 465 LEU H 282 REMARK 465 ASP H 283 REMARK 465 THR H 284 REMARK 465 LEU H 285 REMARK 465 SER H 286 REMARK 465 SER H 287 REMARK 465 SER H 288 REMARK 465 SER H 289 REMARK 465 THR H 290 REMARK 465 SER H 291 REMARK 465 ASP H 292 REMARK 465 CYS H 293 REMARK 465 ALA H 294 REMARK 465 ILE H 295 REMARK 465 CYS H 296 REMARK 465 LEU H 297 REMARK 465 GLU H 298 REMARK 465 LYS H 299 REMARK 465 TYR H 300 REMARK 465 ILE H 301 REMARK 465 ASP H 302 REMARK 465 GLY H 303 REMARK 465 GLU H 304 REMARK 465 GLU H 305 REMARK 465 LEU H 306 REMARK 465 ARG H 307 REMARK 465 VAL H 308 REMARK 465 ILE H 309 REMARK 465 PRO H 310 REMARK 465 CYS H 311 REMARK 465 THR H 312 REMARK 465 HIS H 313 REMARK 465 ARG H 314 REMARK 465 PHE H 315 REMARK 465 HIS H 316 REMARK 465 ARG H 317 REMARK 465 LYS H 318 REMARK 465 CYS H 319 REMARK 465 VAL H 320 REMARK 465 ASP H 321 REMARK 465 PRO H 322 REMARK 465 TRP H 323 REMARK 465 LEU H 324 REMARK 465 LEU H 325 REMARK 465 GLN H 326 REMARK 465 HIS H 327 REMARK 465 HIS H 328 REMARK 465 THR H 329 REMARK 465 CYS H 330 REMARK 465 PRO H 331 REMARK 465 HIS H 332 REMARK 465 CYS H 333 REMARK 465 ARG H 334 REMARK 465 HIS H 335 REMARK 465 ASN H 336 REMARK 465 ILE H 337 REMARK 465 ILE H 338 REMARK 465 GLU H 339 REMARK 465 GLN H 340 REMARK 465 LYS H 341 REMARK 465 GLY H 342 REMARK 465 ASN H 343 REMARK 465 PRO H 344 REMARK 465 SER H 345 REMARK 465 ALA H 346 REMARK 465 VAL H 347 REMARK 465 CYS H 348 REMARK 465 VAL H 349 REMARK 465 GLU H 350 REMARK 465 THR H 351 REMARK 465 SER H 352 REMARK 465 ASN H 353 REMARK 465 LEU H 354 REMARK 465 SER H 355 REMARK 465 ARG H 356 REMARK 465 GLY H 357 REMARK 465 ARG H 358 REMARK 465 GLN H 359 REMARK 465 GLN H 360 REMARK 465 ARG H 361 REMARK 465 VAL H 362 REMARK 465 THR H 363 REMARK 465 LEU H 364 REMARK 465 PRO H 365 REMARK 465 VAL H 366 REMARK 465 HIS H 367 REMARK 465 TYR H 368 REMARK 465 PRO H 369 REMARK 465 GLY H 370 REMARK 465 ARG H 371 REMARK 465 VAL H 372 REMARK 465 HIS H 373 REMARK 465 ARG H 374 REMARK 465 THR H 375 REMARK 465 ASN H 376 REMARK 465 ALA H 377 REMARK 465 ILE H 378 REMARK 465 PRO H 379 REMARK 465 ALA H 380 REMARK 465 TYR H 381 REMARK 465 PRO H 382 REMARK 465 THR H 383 REMARK 465 ARG H 384 REMARK 465 THR H 385 REMARK 465 SER H 386 REMARK 465 MET H 387 REMARK 465 ASP H 388 REMARK 465 SER H 389 REMARK 465 HIS H 390 REMARK 465 GLY H 391 REMARK 465 ASN H 392 REMARK 465 PRO H 393 REMARK 465 VAL H 394 REMARK 465 THR H 395 REMARK 465 LEU H 396 REMARK 465 LEU H 397 REMARK 465 THR H 398 REMARK 465 MET H 399 REMARK 465 ASP H 400 REMARK 465 ARG H 401 REMARK 465 HIS H 402 REMARK 465 GLY H 403 REMARK 465 GLU H 404 REMARK 465 GLN H 405 REMARK 465 SER H 406 REMARK 465 LEU H 407 REMARK 465 TYR H 408 REMARK 465 SER H 409 REMARK 465 PRO H 410 REMARK 465 GLN H 411 REMARK 465 THR H 412 REMARK 465 PRO H 413 REMARK 465 ALA H 414 REMARK 465 TYR H 415 REMARK 465 ILE H 416 REMARK 465 ARG H 417 REMARK 465 SER H 418 REMARK 465 TYR H 419 REMARK 465 PRO H 420 REMARK 465 PRO H 421 REMARK 465 LEU H 422 REMARK 465 HIS H 423 REMARK 465 LEU H 424 REMARK 465 ASP H 425 REMARK 465 HIS H 426 REMARK 465 SER H 427 REMARK 465 LEU H 428 REMARK 465 ALA H 429 REMARK 465 ALA H 430 REMARK 465 HIS H 431 REMARK 465 ARG H 432 REMARK 465 CYS H 433 REMARK 465 GLY H 434 REMARK 465 LEU H 435 REMARK 465 GLU H 436 REMARK 465 HIS H 437 REMARK 465 ARG H 438 REMARK 465 ALA H 439 REMARK 465 TYR H 440 REMARK 465 SER H 441 REMARK 465 PRO H 442 REMARK 465 ALA H 443 REMARK 465 HIS H 444 REMARK 465 PRO H 445 REMARK 465 PHE H 446 REMARK 465 ARG H 447 REMARK 465 ARG H 448 REMARK 465 PRO H 449 REMARK 465 LYS H 450 REMARK 465 LEU H 451 REMARK 465 SER H 452 REMARK 465 GLY H 453 REMARK 465 ARG H 454 REMARK 465 SER H 455 REMARK 465 PHE H 456 REMARK 465 SER H 457 REMARK 465 LYS H 458 REMARK 465 ALA H 459 REMARK 465 ALA H 460 REMARK 465 CYS H 461 REMARK 465 PHE H 462 REMARK 465 SER H 463 REMARK 465 GLN H 464 REMARK 465 TYR H 465 REMARK 465 GLU H 466 REMARK 465 THR H 467 REMARK 465 MET H 468 REMARK 465 TYR H 469 REMARK 465 GLN H 470 REMARK 465 HIS H 471 REMARK 465 TYR H 472 REMARK 465 TYR H 473 REMARK 465 PHE H 474 REMARK 465 GLN H 475 REMARK 465 GLY H 476 REMARK 465 LEU H 477 REMARK 465 SER H 478 REMARK 465 TYR H 479 REMARK 465 PRO H 480 REMARK 465 GLU H 481 REMARK 465 GLN H 482 REMARK 465 GLU H 483 REMARK 465 GLY H 484 REMARK 465 GLN H 485 REMARK 465 SER H 486 REMARK 465 PRO H 487 REMARK 465 PRO H 488 REMARK 465 SER H 489 REMARK 465 LEU H 490 REMARK 465 ALA H 491 REMARK 465 PRO H 492 REMARK 465 ARG H 493 REMARK 465 GLY H 494 REMARK 465 PRO H 495 REMARK 465 ALA H 496 REMARK 465 ARG H 497 REMARK 465 ALA H 498 REMARK 465 PHE H 499 REMARK 465 PRO H 500 REMARK 465 PRO H 501 REMARK 465 SER H 502 REMARK 465 GLY H 503 REMARK 465 SER H 504 REMARK 465 GLY H 505 REMARK 465 SER H 506 REMARK 465 LEU H 507 REMARK 465 LEU H 508 REMARK 465 PHE H 509 REMARK 465 PRO H 510 REMARK 465 THR H 511 REMARK 465 VAL H 512 REMARK 465 VAL H 513 REMARK 465 HIS H 514 REMARK 465 VAL H 515 REMARK 465 ALA H 516 REMARK 465 PRO H 517 REMARK 465 PRO H 518 REMARK 465 SER H 519 REMARK 465 HIS H 520 REMARK 465 LEU H 521 REMARK 465 GLU H 522 REMARK 465 SER H 523 REMARK 465 GLY H 524 REMARK 465 SER H 525 REMARK 465 THR H 526 REMARK 465 SER H 527 REMARK 465 SER H 528 REMARK 465 PHE H 529 REMARK 465 SER H 530 REMARK 465 CYS H 531 REMARK 465 TYR H 532 REMARK 465 HIS H 533 REMARK 465 GLY H 534 REMARK 465 HIS H 535 REMARK 465 ARG H 536 REMARK 465 SER H 537 REMARK 465 VAL H 538 REMARK 465 CYS H 539 REMARK 465 SER H 540 REMARK 465 GLY H 541 REMARK 465 TYR H 542 REMARK 465 LEU H 543 REMARK 465 ALA H 544 REMARK 465 ASP H 545 REMARK 465 CYS H 546 REMARK 465 PRO H 547 REMARK 465 GLY H 548 REMARK 465 SER H 549 REMARK 465 ASP H 550 REMARK 465 SER H 551 REMARK 465 SER H 552 REMARK 465 SER H 553 REMARK 465 SER H 554 REMARK 465 SER H 555 REMARK 465 SER H 556 REMARK 465 SER H 557 REMARK 465 GLY H 558 REMARK 465 GLN H 559 REMARK 465 CYS H 560 REMARK 465 HIS H 561 REMARK 465 CYS H 562 REMARK 465 SER H 563 REMARK 465 SER H 564 REMARK 465 SER H 565 REMARK 465 ASP H 566 REMARK 465 SER H 567 REMARK 465 VAL H 568 REMARK 465 VAL H 569 REMARK 465 ASP H 570 REMARK 465 CYS H 571 REMARK 465 THR H 572 REMARK 465 GLU H 573 REMARK 465 VAL H 574 REMARK 465 SER H 575 REMARK 465 ASN H 576 REMARK 465 GLN H 577 REMARK 465 GLY H 578 REMARK 465 VAL H 579 REMARK 465 TYR H 580 REMARK 465 GLY H 581 REMARK 465 SER H 582 REMARK 465 CYS H 583 REMARK 465 SER H 584 REMARK 465 THR H 585 REMARK 465 PHE H 586 REMARK 465 ARG H 587 REMARK 465 SER H 588 REMARK 465 SER H 589 REMARK 465 LEU H 590 REMARK 465 SER H 591 REMARK 465 SER H 592 REMARK 465 ASP H 593 REMARK 465 TYR H 594 REMARK 465 ASP H 595 REMARK 465 PRO H 596 REMARK 465 PHE H 597 REMARK 465 ILE H 598 REMARK 465 TYR H 599 REMARK 465 ARG H 600 REMARK 465 SER H 601 REMARK 465 ARG H 602 REMARK 465 SER H 603 REMARK 465 PRO H 604 REMARK 465 CYS H 605 REMARK 465 ARG H 606 REMARK 465 ALA H 607 REMARK 465 SER H 608 REMARK 465 GLU H 609 REMARK 465 ALA H 610 REMARK 465 GLY H 611 REMARK 465 GLY H 612 REMARK 465 SER H 613 REMARK 465 GLY H 614 REMARK 465 SER H 615 REMARK 465 SER H 616 REMARK 465 GLY H 617 REMARK 465 ARG H 618 REMARK 465 GLY H 619 REMARK 465 PRO H 620 REMARK 465 ALA H 621 REMARK 465 LEU H 622 REMARK 465 CYS H 623 REMARK 465 PHE H 624 REMARK 465 GLU H 625 REMARK 465 GLY H 626 REMARK 465 SER H 627 REMARK 465 PRO H 628 REMARK 465 PRO H 629 REMARK 465 PRO H 630 REMARK 465 GLU H 631 REMARK 465 GLU H 632 REMARK 465 LEU H 633 REMARK 465 PRO H 634 REMARK 465 ALA H 635 REMARK 465 VAL H 636 REMARK 465 HIS H 637 REMARK 465 SER H 638 REMARK 465 HIS H 639 REMARK 465 GLY H 640 REMARK 465 ALA H 641 REMARK 465 GLY H 642 REMARK 465 ARG H 643 REMARK 465 GLY H 644 REMARK 465 GLU H 645 REMARK 465 PRO H 646 REMARK 465 TRP H 647 REMARK 465 PRO H 648 REMARK 465 GLY H 649 REMARK 465 PRO H 650 REMARK 465 ALA H 651 REMARK 465 SER H 652 REMARK 465 PRO H 653 REMARK 465 SER H 654 REMARK 465 GLY H 655 REMARK 465 ASP H 656 REMARK 465 GLN H 657 REMARK 465 VAL H 658 REMARK 465 SER H 659 REMARK 465 THR H 660 REMARK 465 CYS H 661 REMARK 465 SER H 662 REMARK 465 LEU H 663 REMARK 465 GLU H 664 REMARK 465 MET H 665 REMARK 465 ASN H 666 REMARK 465 TYR H 667 REMARK 465 SER H 668 REMARK 465 SER H 669 REMARK 465 ASN H 670 REMARK 465 SER H 671 REMARK 465 SER H 672 REMARK 465 LEU H 673 REMARK 465 GLU H 674 REMARK 465 HIS H 675 REMARK 465 ARG H 676 REMARK 465 GLY H 677 REMARK 465 PRO H 678 REMARK 465 ASN H 679 REMARK 465 SER H 680 REMARK 465 SER H 681 REMARK 465 THR H 682 REMARK 465 SER H 683 REMARK 465 GLU H 684 REMARK 465 VAL H 685 REMARK 465 GLY H 686 REMARK 465 LEU H 687 REMARK 465 GLU H 688 REMARK 465 ALA H 689 REMARK 465 SER H 690 REMARK 465 PRO H 691 REMARK 465 GLY H 692 REMARK 465 ALA H 693 REMARK 465 ALA H 694 REMARK 465 PRO H 695 REMARK 465 ASP H 696 REMARK 465 LEU H 697 REMARK 465 ARG H 698 REMARK 465 ARG H 699 REMARK 465 THR H 700 REMARK 465 TRP H 701 REMARK 465 LYS H 702 REMARK 465 GLY H 703 REMARK 465 GLY H 704 REMARK 465 HIS H 705 REMARK 465 GLU H 706 REMARK 465 LEU H 707 REMARK 465 PRO H 708 REMARK 465 SER H 709 REMARK 465 CYS H 710 REMARK 465 ALA H 711 REMARK 465 CYS H 712 REMARK 465 CYS H 713 REMARK 465 CYS H 714 REMARK 465 GLU H 715 REMARK 465 PRO H 716 REMARK 465 GLN H 717 REMARK 465 PRO H 718 REMARK 465 SER H 719 REMARK 465 PRO H 720 REMARK 465 ALA H 721 REMARK 465 GLY H 722 REMARK 465 PRO H 723 REMARK 465 SER H 724 REMARK 465 ALA H 725 REMARK 465 GLY H 726 REMARK 465 ALA H 727 REMARK 465 ALA H 728 REMARK 465 GLY H 729 REMARK 465 SER H 730 REMARK 465 SER H 731 REMARK 465 THR H 732 REMARK 465 LEU H 733 REMARK 465 PHE H 734 REMARK 465 LEU H 735 REMARK 465 GLY H 736 REMARK 465 PRO H 737 REMARK 465 HIS H 738 REMARK 465 LEU H 739 REMARK 465 TYR H 740 REMARK 465 GLU H 741 REMARK 465 GLY H 742 REMARK 465 SER H 743 REMARK 465 GLY H 744 REMARK 465 PRO H 745 REMARK 465 ALA H 746 REMARK 465 GLY H 747 REMARK 465 GLY H 748 REMARK 465 GLU H 749 REMARK 465 PRO H 750 REMARK 465 GLN H 751 REMARK 465 SER H 752 REMARK 465 GLY H 753 REMARK 465 SER H 754 REMARK 465 SER H 755 REMARK 465 GLN H 756 REMARK 465 GLY H 757 REMARK 465 LEU H 758 REMARK 465 TYR H 759 REMARK 465 GLY H 760 REMARK 465 LEU H 761 REMARK 465 HIS H 762 REMARK 465 PRO H 763 REMARK 465 ASP H 764 REMARK 465 HIS H 765 REMARK 465 LEU H 766 REMARK 465 PRO H 767 REMARK 465 ARG H 768 REMARK 465 THR H 769 REMARK 465 ASP H 770 REMARK 465 GLY H 771 REMARK 465 VAL H 772 REMARK 465 LYS H 773 REMARK 465 TYR H 774 REMARK 465 GLU H 775 REMARK 465 GLY H 776 REMARK 465 LEU H 777 REMARK 465 PRO H 778 REMARK 465 CYS H 779 REMARK 465 CYS H 780 REMARK 465 PHE H 781 REMARK 465 TYR H 782 REMARK 465 GLU H 783 REMARK 465 GLU H 784 REMARK 465 LYS H 785 REMARK 465 GLN H 786 REMARK 465 VAL H 787 REMARK 465 ALA H 788 REMARK 465 ARG H 789 REMARK 465 GLY H 790 REMARK 465 GLY H 791 REMARK 465 GLY H 792 REMARK 465 GLY H 793 REMARK 465 GLY H 794 REMARK 465 SER H 795 REMARK 465 GLY H 796 REMARK 465 CYS H 797 REMARK 465 TYR H 798 REMARK 465 THR H 799 REMARK 465 GLU H 800 REMARK 465 ASP H 801 REMARK 465 TYR H 802 REMARK 465 SER H 803 REMARK 465 VAL H 804 REMARK 465 SER H 805 REMARK 465 VAL H 806 REMARK 465 GLN H 807 REMARK 465 TYR H 808 REMARK 465 THR H 809 REMARK 465 LEU H 810 REMARK 465 THR H 811 REMARK 465 GLU H 812 REMARK 465 GLU H 813 REMARK 465 PRO H 814 REMARK 465 PRO H 815 REMARK 465 PRO H 816 REMARK 465 GLY H 817 REMARK 465 CYS H 818 REMARK 465 TYR H 819 REMARK 465 PRO H 820 REMARK 465 GLY H 821 REMARK 465 ALA H 822 REMARK 465 ARG H 823 REMARK 465 ASP H 824 REMARK 465 LEU H 825 REMARK 465 SER H 826 REMARK 465 GLN H 827 REMARK 465 ARG H 828 REMARK 465 ILE H 829 REMARK 465 PRO H 830 REMARK 465 ILE H 831 REMARK 465 ILE H 832 REMARK 465 PRO H 833 REMARK 465 GLU H 834 REMARK 465 ASP H 835 REMARK 465 VAL H 836 REMARK 465 ASP H 837 REMARK 465 CYS H 838 REMARK 465 ASP H 839 REMARK 465 LEU H 840 REMARK 465 GLY H 841 REMARK 465 LEU H 842 REMARK 465 PRO H 843 REMARK 465 SER H 844 REMARK 465 ASP H 845 REMARK 465 CYS H 846 REMARK 465 GLN H 847 REMARK 465 GLY H 848 REMARK 465 THR H 849 REMARK 465 HIS H 850 REMARK 465 SER H 851 REMARK 465 LEU H 852 REMARK 465 GLY H 853 REMARK 465 SER H 854 REMARK 465 TRP H 855 REMARK 465 GLY H 856 REMARK 465 GLY H 857 REMARK 465 THR H 858 REMARK 465 ARG H 859 REMARK 465 GLY H 860 REMARK 465 PRO H 861 REMARK 465 ASP H 862 REMARK 465 THR H 863 REMARK 465 PRO H 864 REMARK 465 ARG H 865 REMARK 465 PRO H 866 REMARK 465 HIS H 867 REMARK 465 ARG H 868 REMARK 465 GLY H 869 REMARK 465 LEU H 870 REMARK 465 GLY H 871 REMARK 465 ALA H 872 REMARK 465 THR H 873 REMARK 465 ARG H 874 REMARK 465 GLU H 875 REMARK 465 GLU H 876 REMARK 465 GLU H 877 REMARK 465 ARG H 878 REMARK 465 ALA H 879 REMARK 465 LEU H 880 REMARK 465 CYS H 881 REMARK 465 CYS H 882 REMARK 465 GLN H 883 REMARK 465 ALA H 884 REMARK 465 ARG H 885 REMARK 465 ALA H 886 REMARK 465 LEU H 887 REMARK 465 LEU H 888 REMARK 465 ARG H 889 REMARK 465 PRO H 890 REMARK 465 GLY H 891 REMARK 465 CYS H 892 REMARK 465 PRO H 893 REMARK 465 PRO H 894 REMARK 465 GLU H 895 REMARK 465 GLU H 896 REMARK 465 ALA H 897 REMARK 465 GLY H 898 REMARK 465 ALA H 899 REMARK 465 VAL H 900 REMARK 465 ARG H 901 REMARK 465 ALA H 902 REMARK 465 ASN H 903 REMARK 465 PHE H 904 REMARK 465 PRO H 905 REMARK 465 SER H 906 REMARK 465 ALA H 907 REMARK 465 LEU H 908 REMARK 465 GLN H 909 REMARK 465 ASP H 910 REMARK 465 THR H 911 REMARK 465 GLN H 912 REMARK 465 GLU H 913 REMARK 465 SER H 914 REMARK 465 SER H 915 REMARK 465 THR H 916 REMARK 465 THR H 917 REMARK 465 ALA H 918 REMARK 465 THR H 919 REMARK 465 GLU H 920 REMARK 465 ALA H 921 REMARK 465 ALA H 922 REMARK 465 GLY H 923 REMARK 465 PRO H 924 REMARK 465 ARG H 925 REMARK 465 SER H 926 REMARK 465 HIS H 927 REMARK 465 SER H 928 REMARK 465 ALA H 929 REMARK 465 ASP H 930 REMARK 465 SER H 931 REMARK 465 SER H 932 REMARK 465 SER H 933 REMARK 465 PRO H 934 REMARK 465 GLY H 935 REMARK 465 ALA H 936 REMARK 465 ALA J 130 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS C 56 CG CD CE NZ REMARK 470 ARG G 54 CG CD NE CZ NH1 NH2 REMARK 470 GLN G 57 CG CD OE1 NE2 REMARK 470 GLU G 137 CG CD OE1 OE2 REMARK 470 ARG J 54 CG CD NE CZ NH1 NH2 REMARK 470 GLN J 57 CG CD OE1 NE2 REMARK 470 GLU J 137 CG CD OE1 OE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG1 THR A 329 OD1 ASN A 353 2.10 REMARK 500 OG SER H 69 O GLY H 72 2.13 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LEU A 88 33.84 -99.01 REMARK 500 LEU A 104 59.88 -94.75 REMARK 500 HIS A 140 57.47 -95.86 REMARK 500 LEU A 160 31.61 -140.95 REMARK 500 ASN A 187 -169.37 -79.89 REMARK 500 LYS A 212 57.03 -97.41 REMARK 500 ASN A 236 57.27 -95.15 REMARK 500 SER A 259 56.23 -97.72 REMARK 500 ASP A 281 -4.85 78.03 REMARK 500 SER E 455 72.54 52.24 REMARK 500 SER C 71 -145.72 63.14 REMARK 500 THR C 75 133.78 69.65 REMARK 500 PRO C 213 46.35 -84.92 REMARK 500 SER G 45 -60.66 -93.93 REMARK 500 SER H 68 -163.78 59.73 REMARK 500 SER J 45 -62.51 -91.84 REMARK 500 LEU J 135 -60.45 -91.76 REMARK 500 GLU J 137 16.90 57.02 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-38307 RELATED DB: EMDB REMARK 900 LGR4-RSPO2-ZNRF3(1:2:2) DBREF 8XFP A 1 951 UNP Q9BXB1 LGR4_HUMAN 1 951 DBREF 8XFP E 1 560 PDB 8XFP 8XFP 1 560 DBREF 8XFP C 1 936 UNP Q9ULT6 ZNRF3_HUMAN 1 936 DBREF 8XFP G 41 141 UNP Q8BFU0 RSPO2_MOUSE 41 141 DBREF 8XFP H 1 936 UNP Q9ULT6 ZNRF3_HUMAN 1 936 DBREF 8XFP J 41 141 UNP Q8BFU0 RSPO2_MOUSE 41 141 SEQADV 8XFP ALA G 130 UNP Q8BFU0 ASP 130 CONFLICT SEQADV 8XFP ALA J 130 UNP Q8BFU0 ASP 130 CONFLICT SEQRES 1 A 951 MET PRO GLY PRO LEU GLY LEU LEU CYS PHE LEU ALA LEU SEQRES 2 A 951 GLY LEU LEU GLY SER ALA GLY PRO SER GLY ALA ALA PRO SEQRES 3 A 951 PRO LEU CYS ALA ALA PRO CYS SER CYS ASP GLY ASP ARG SEQRES 4 A 951 ARG VAL ASP CYS SER GLY LYS GLY LEU THR ALA VAL PRO SEQRES 5 A 951 GLU GLY LEU SER ALA PHE THR GLN ALA LEU ASP ILE SER SEQRES 6 A 951 MET ASN ASN ILE THR GLN LEU PRO GLU ASP ALA PHE LYS SEQRES 7 A 951 ASN PHE PRO PHE LEU GLU GLU LEU GLN LEU ALA GLY ASN SEQRES 8 A 951 ASP LEU SER PHE ILE HIS PRO LYS ALA LEU SER GLY LEU SEQRES 9 A 951 LYS GLU LEU LYS VAL LEU THR LEU GLN ASN ASN GLN LEU SEQRES 10 A 951 LYS THR VAL PRO SER GLU ALA ILE ARG GLY LEU SER ALA SEQRES 11 A 951 LEU GLN SER LEU ARG LEU ASP ALA ASN HIS ILE THR SER SEQRES 12 A 951 VAL PRO GLU ASP SER PHE GLU GLY LEU VAL GLN LEU ARG SEQRES 13 A 951 HIS LEU TRP LEU ASP ASP ASN SER LEU THR GLU VAL PRO SEQRES 14 A 951 VAL HIS PRO LEU SER ASN LEU PRO THR LEU GLN ALA LEU SEQRES 15 A 951 THR LEU ALA LEU ASN LYS ILE SER SER ILE PRO ASP PHE SEQRES 16 A 951 ALA PHE THR ASN LEU SER SER LEU VAL VAL LEU HIS LEU SEQRES 17 A 951 HIS ASN ASN LYS ILE ARG SER LEU SER GLN HIS CYS PHE SEQRES 18 A 951 ASP GLY LEU ASP ASN LEU GLU THR LEU ASP LEU ASN TYR SEQRES 19 A 951 ASN ASN LEU GLY GLU PHE PRO GLN ALA ILE LYS ALA LEU SEQRES 20 A 951 PRO SER LEU LYS GLU LEU GLY PHE HIS SER ASN SER ILE SEQRES 21 A 951 SER VAL ILE PRO ASP GLY ALA PHE ASP GLY ASN PRO LEU SEQRES 22 A 951 LEU ARG THR ILE HIS LEU TYR ASP ASN PRO LEU SER PHE SEQRES 23 A 951 VAL GLY ASN SER ALA PHE HIS ASN LEU SER ASP LEU HIS SEQRES 24 A 951 SER LEU VAL ILE ARG GLY ALA SER MET VAL GLN GLN PHE SEQRES 25 A 951 PRO ASN LEU THR GLY THR VAL HIS LEU GLU SER LEU THR SEQRES 26 A 951 LEU THR GLY THR LYS ILE SER SER ILE PRO ASN ASN LEU SEQRES 27 A 951 CYS GLN GLU GLN LYS MET LEU ARG THR LEU ASP LEU SER SEQRES 28 A 951 TYR ASN ASN ILE ARG ASP LEU PRO SER PHE ASN GLY CYS SEQRES 29 A 951 HIS ALA LEU GLU GLU ILE SER LEU GLN ARG ASN GLN ILE SEQRES 30 A 951 TYR GLN ILE LYS GLU GLY THR PHE GLN GLY LEU ILE SER SEQRES 31 A 951 LEU ARG ILE LEU ASP LEU SER ARG ASN LEU ILE HIS GLU SEQRES 32 A 951 ILE HIS SER ARG ALA PHE ALA THR LEU GLY PRO ILE THR SEQRES 33 A 951 ASN LEU ASP VAL SER PHE ASN GLU LEU THR SER PHE PRO SEQRES 34 A 951 THR GLU GLY LEU ASN GLY LEU ASN GLN LEU LYS LEU VAL SEQRES 35 A 951 GLY ASN PHE LYS LEU LYS GLU ALA LEU ALA ALA LYS ASP SEQRES 36 A 951 PHE VAL ASN LEU ARG SER LEU SER VAL PRO TYR ALA TYR SEQRES 37 A 951 GLN CYS CYS ALA PHE TRP GLY CYS ASP SER TYR ALA ASN SEQRES 38 A 951 LEU ASN THR GLU ASP ASN SER LEU GLN ASP HIS SER VAL SEQRES 39 A 951 ALA GLN GLU LYS GLY THR ALA ASP ALA ALA ASN VAL THR SEQRES 40 A 951 SER THR LEU GLU ASN GLU GLU HIS SER GLN ILE ILE ILE SEQRES 41 A 951 HIS CYS THR PRO SER THR GLY ALA PHE LYS PRO CYS GLU SEQRES 42 A 951 TYR LEU LEU GLY SER TRP MET ILE ARG LEU THR VAL TRP SEQRES 43 A 951 PHE ILE PHE LEU VAL ALA LEU PHE PHE ASN LEU LEU VAL SEQRES 44 A 951 ILE LEU THR THR PHE ALA SER CYS THR SER LEU PRO SER SEQRES 45 A 951 SER LYS LEU PHE ILE GLY LEU ILE SER VAL SER ASN LEU SEQRES 46 A 951 PHE MET GLY ILE TYR THR GLY ILE LEU THR PHE LEU ASP SEQRES 47 A 951 ALA VAL SER TRP GLY ARG PHE ALA GLU PHE GLY ILE TRP SEQRES 48 A 951 TRP GLU THR GLY SER GLY CYS LYS VAL ALA GLY PHE LEU SEQRES 49 A 951 ALA VAL PHE SER SER GLU SER ALA ILE PHE LEU LEU MET SEQRES 50 A 951 LEU ALA THR VAL GLU ARG SER LEU SER ALA LYS ASP ILE SEQRES 51 A 951 MET LYS ASN GLY LYS SER ASN HIS LEU LYS GLN PHE ARG SEQRES 52 A 951 VAL ALA ALA LEU LEU ALA PHE LEU GLY ALA THR VAL ALA SEQRES 53 A 951 GLY CYS PHE PRO LEU PHE HIS ARG GLY GLU TYR SER ALA SEQRES 54 A 951 SER PRO LEU CYS LEU PRO PHE PRO THR GLY GLU THR PRO SEQRES 55 A 951 SER LEU GLY PHE THR VAL THR LEU VAL LEU LEU ASN SER SEQRES 56 A 951 LEU ALA PHE LEU LEU MET ALA VAL ILE TYR THR LYS LEU SEQRES 57 A 951 TYR CYS ASN LEU GLU LYS GLU ASP LEU SER GLU ASN SER SEQRES 58 A 951 GLN SER SER MET ILE LYS HIS VAL ALA TRP LEU ILE PHE SEQRES 59 A 951 THR ASN CYS ILE PHE PHE CYS PRO VAL ALA PHE PHE SER SEQRES 60 A 951 PHE ALA PRO LEU ILE THR ALA ILE SER ILE SER PRO GLU SEQRES 61 A 951 ILE MET LYS SER VAL THR LEU ILE PHE PHE PRO LEU PRO SEQRES 62 A 951 ALA CYS LEU ASN PRO VAL LEU TYR VAL PHE PHE ASN PRO SEQRES 63 A 951 LYS PHE LYS GLU ASP TRP LYS LEU LEU LYS ARG ARG VAL SEQRES 64 A 951 THR LYS LYS SER GLY SER VAL SER VAL SER ILE SER SER SEQRES 65 A 951 GLN GLY GLY CYS LEU GLU GLN ASP PHE TYR TYR ASP CYS SEQRES 66 A 951 GLY MET TYR SER HIS LEU GLN GLY ASN LEU THR VAL CYS SEQRES 67 A 951 ASP CYS CYS GLU SER PHE LEU LEU THR LYS PRO VAL SER SEQRES 68 A 951 CYS LYS HIS LEU ILE LYS SER HIS SER CYS PRO ALA LEU SEQRES 69 A 951 ALA VAL ALA SER CYS GLN ARG PRO GLU GLY TYR TRP SER SEQRES 70 A 951 ASP CYS GLY THR GLN SER ALA HIS SER ASP TYR ALA ASP SEQRES 71 A 951 GLU GLU ASP SER PHE VAL SER ASP SER SER ASP GLN VAL SEQRES 72 A 951 GLN ALA CYS GLY ARG ALA CYS PHE TYR GLN SER ARG GLY SEQRES 73 A 951 PHE PRO LEU VAL ARG TYR ALA TYR ASN LEU PRO ARG VAL SEQRES 74 A 951 LYS ASP SEQRES 1 E 560 MET LYS LYS ILE TRP LEU ALA LEU ALA GLY LEU VAL LEU SEQRES 2 E 560 ALA PHE SER ALA SER ALA GLN VAL GLN LEU VAL GLU SER SEQRES 3 E 560 GLY GLY GLY LEU VAL GLN THR LYS THR THR THR SER VAL SEQRES 4 E 560 ILE ASP THR THR ASN ASP ALA GLN ASN LEU LEU THR GLN SEQRES 5 E 560 ALA GLN THR ILE VAL ASN THR LEU LYS ASP TYR CYS PRO SEQRES 6 E 560 ILE LEU ILE ALA LYS SER SER SER SER ASN GLY GLY THR SEQRES 7 E 560 ASN ASN ALA ASN THR PRO SER TRP GLN THR ALA GLY GLY SEQRES 8 E 560 GLY LYS ASN SER CYS ALA THR PHE GLY ALA GLU PHE SER SEQRES 9 E 560 ALA ALA SER ASP MET ILE ASN ASN ALA GLN LYS ILE VAL SEQRES 10 E 560 GLN GLU THR GLN GLN LEU SER ALA ASN GLN PRO LYS ASN SEQRES 11 E 560 ILE THR GLN PRO HIS ASN LEU ASN LEU ASN SER PRO SER SEQRES 12 E 560 SER LEU THR ALA LEU ALA GLN LYS MET LEU LYS ASN ALA SEQRES 13 E 560 GLN SER GLN ALA GLU ILE LEU LYS LEU ALA ASN GLN VAL SEQRES 14 E 560 GLU SER ASP PHE ASN LYS LEU SER SER GLY HIS LEU LYS SEQRES 15 E 560 ASP TYR ILE GLY LYS CYS ASP ALA SER ALA ILE SER SER SEQRES 16 E 560 ALA ASN MET THR MET GLN ASN GLN LYS ASN ASN TRP GLY SEQRES 17 E 560 ASN GLY CYS ALA GLY VAL GLU GLU THR GLN SER LEU LEU SEQRES 18 E 560 LYS THR SER ALA ALA ASP PHE ASN ASN GLN THR PRO GLN SEQRES 19 E 560 ILE ASN GLN ALA GLN ASN LEU ALA ASN THR LEU ILE GLN SEQRES 20 E 560 GLU LEU GLY ASN ASN PRO PHE ARG ALA SER GLY GLY GLY SEQRES 21 E 560 SER GLY GLY GLY GLY SER GLY LYS LEU SER ASP THR TYR SEQRES 22 E 560 GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY THR SEQRES 23 E 560 ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA VAL SEQRES 24 E 560 ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY GLY SEQRES 25 E 560 THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU ALA SEQRES 26 E 560 LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY TYR SEQRES 27 E 560 ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY GLU SEQRES 28 E 560 ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN GLY SEQRES 29 E 560 ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SER SEQRES 30 E 560 ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU LYS SEQRES 31 E 560 ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR GLU SEQRES 32 E 560 LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA LEU SEQRES 33 E 560 LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY GLU SEQRES 34 E 560 LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SER SEQRES 35 E 560 LEU ARG LEU SER CYS ALA ALA SER GLY TYR THR TYR SER SEQRES 36 E 560 PRO TYR CYS MET GLY TRP PHE ARG GLN ALA PRO GLY LYS SEQRES 37 E 560 ALA ARG GLU GLY VAL ALA THR VAL ASP LEU ASP GLY SER SEQRES 38 E 560 THR ILE TYR ALA ASP SER VAL LYS GLY ARG PHE THR ILE SEQRES 39 E 560 SER GLN ASP ASN ALA LYS ASN THR LEU TYR LEU GLN MET SEQRES 40 E 560 ASN SER LEU LYS PRO GLU ASP THR ALA MET TYR TYR CYS SEQRES 41 E 560 ALA SER ARG THR ARG ALA GLY VAL THR CYS GLY LEU ASN SEQRES 42 E 560 TRP ALA ILE PHE SER TYR TRP GLY GLN GLY THR GLN VAL SEQRES 43 E 560 THR VAL SER SER HIS HIS HIS HIS HIS HIS GLU PRO GLU SEQRES 44 E 560 ALA SEQRES 1 C 936 MET ARG PRO ARG SER GLY GLY ARG PRO GLY ALA THR GLY SEQRES 2 C 936 ARG ARG ARG ARG ARG LEU ARG ARG ARG PRO ARG GLY LEU SEQRES 3 C 936 ARG CYS SER ARG LEU PRO PRO PRO PRO PRO LEU PRO LEU SEQRES 4 C 936 LEU LEU GLY LEU LEU LEU ALA ALA ALA GLY PRO GLY ALA SEQRES 5 C 936 ALA ARG ALA LYS GLU THR ALA PHE VAL GLU VAL VAL LEU SEQRES 6 C 936 PHE GLU SER SER PRO SER GLY ASP TYR THR THR TYR THR SEQRES 7 C 936 THR GLY LEU THR GLY ARG PHE SER ARG ALA GLY ALA THR SEQRES 8 C 936 LEU SER ALA GLU GLY GLU ILE VAL GLN MET HIS PRO LEU SEQRES 9 C 936 GLY LEU CYS ASN ASN ASN ASP GLU GLU ASP LEU TYR GLU SEQRES 10 C 936 TYR GLY TRP VAL GLY VAL VAL LYS LEU GLU GLN PRO GLU SEQRES 11 C 936 LEU ASP PRO LYS PRO CYS LEU THR VAL LEU GLY LYS ALA SEQRES 12 C 936 LYS ARG ALA VAL GLN ARG GLY ALA THR ALA VAL ILE PHE SEQRES 13 C 936 ASP VAL SER GLU ASN PRO GLU ALA ILE ASP GLN LEU ASN SEQRES 14 C 936 GLN GLY SER GLU ASP PRO LEU LYS ARG PRO VAL VAL TYR SEQRES 15 C 936 VAL LYS GLY ALA ASP ALA ILE LYS LEU MET ASN ILE VAL SEQRES 16 C 936 ASN LYS GLN LYS VAL ALA ARG ALA ARG ILE GLN HIS ARG SEQRES 17 C 936 PRO PRO ARG GLN PRO THR GLU TYR PHE ASP MET GLY ILE SEQRES 18 C 936 PHE LEU ALA PHE PHE VAL VAL VAL SER LEU VAL CYS LEU SEQRES 19 C 936 ILE LEU LEU VAL LYS ILE LYS LEU LYS GLN ARG ARG SER SEQRES 20 C 936 GLN ASN SER MET ASN ARG LEU ALA VAL GLN ALA LEU GLU SEQRES 21 C 936 LYS MET GLU THR ARG LYS PHE ASN SER LYS SER LYS GLY SEQRES 22 C 936 ARG ARG GLU GLY SER CYS GLY ALA LEU ASP THR LEU SER SEQRES 23 C 936 SER SER SER THR SER ASP CYS ALA ILE CYS LEU GLU LYS SEQRES 24 C 936 TYR ILE ASP GLY GLU GLU LEU ARG VAL ILE PRO CYS THR SEQRES 25 C 936 HIS ARG PHE HIS ARG LYS CYS VAL ASP PRO TRP LEU LEU SEQRES 26 C 936 GLN HIS HIS THR CYS PRO HIS CYS ARG HIS ASN ILE ILE SEQRES 27 C 936 GLU GLN LYS GLY ASN PRO SER ALA VAL CYS VAL GLU THR SEQRES 28 C 936 SER ASN LEU SER ARG GLY ARG GLN GLN ARG VAL THR LEU SEQRES 29 C 936 PRO VAL HIS TYR PRO GLY ARG VAL HIS ARG THR ASN ALA SEQRES 30 C 936 ILE PRO ALA TYR PRO THR ARG THR SER MET ASP SER HIS SEQRES 31 C 936 GLY ASN PRO VAL THR LEU LEU THR MET ASP ARG HIS GLY SEQRES 32 C 936 GLU GLN SER LEU TYR SER PRO GLN THR PRO ALA TYR ILE SEQRES 33 C 936 ARG SER TYR PRO PRO LEU HIS LEU ASP HIS SER LEU ALA SEQRES 34 C 936 ALA HIS ARG CYS GLY LEU GLU HIS ARG ALA TYR SER PRO SEQRES 35 C 936 ALA HIS PRO PHE ARG ARG PRO LYS LEU SER GLY ARG SER SEQRES 36 C 936 PHE SER LYS ALA ALA CYS PHE SER GLN TYR GLU THR MET SEQRES 37 C 936 TYR GLN HIS TYR TYR PHE GLN GLY LEU SER TYR PRO GLU SEQRES 38 C 936 GLN GLU GLY GLN SER PRO PRO SER LEU ALA PRO ARG GLY SEQRES 39 C 936 PRO ALA ARG ALA PHE PRO PRO SER GLY SER GLY SER LEU SEQRES 40 C 936 LEU PHE PRO THR VAL VAL HIS VAL ALA PRO PRO SER HIS SEQRES 41 C 936 LEU GLU SER GLY SER THR SER SER PHE SER CYS TYR HIS SEQRES 42 C 936 GLY HIS ARG SER VAL CYS SER GLY TYR LEU ALA ASP CYS SEQRES 43 C 936 PRO GLY SER ASP SER SER SER SER SER SER SER GLY GLN SEQRES 44 C 936 CYS HIS CYS SER SER SER ASP SER VAL VAL ASP CYS THR SEQRES 45 C 936 GLU VAL SER ASN GLN GLY VAL TYR GLY SER CYS SER THR SEQRES 46 C 936 PHE ARG SER SER LEU SER SER ASP TYR ASP PRO PHE ILE SEQRES 47 C 936 TYR ARG SER ARG SER PRO CYS ARG ALA SER GLU ALA GLY SEQRES 48 C 936 GLY SER GLY SER SER GLY ARG GLY PRO ALA LEU CYS PHE SEQRES 49 C 936 GLU GLY SER PRO PRO PRO GLU GLU LEU PRO ALA VAL HIS SEQRES 50 C 936 SER HIS GLY ALA GLY ARG GLY GLU PRO TRP PRO GLY PRO SEQRES 51 C 936 ALA SER PRO SER GLY ASP GLN VAL SER THR CYS SER LEU SEQRES 52 C 936 GLU MET ASN TYR SER SER ASN SER SER LEU GLU HIS ARG SEQRES 53 C 936 GLY PRO ASN SER SER THR SER GLU VAL GLY LEU GLU ALA SEQRES 54 C 936 SER PRO GLY ALA ALA PRO ASP LEU ARG ARG THR TRP LYS SEQRES 55 C 936 GLY GLY HIS GLU LEU PRO SER CYS ALA CYS CYS CYS GLU SEQRES 56 C 936 PRO GLN PRO SER PRO ALA GLY PRO SER ALA GLY ALA ALA SEQRES 57 C 936 GLY SER SER THR LEU PHE LEU GLY PRO HIS LEU TYR GLU SEQRES 58 C 936 GLY SER GLY PRO ALA GLY GLY GLU PRO GLN SER GLY SER SEQRES 59 C 936 SER GLN GLY LEU TYR GLY LEU HIS PRO ASP HIS LEU PRO SEQRES 60 C 936 ARG THR ASP GLY VAL LYS TYR GLU GLY LEU PRO CYS CYS SEQRES 61 C 936 PHE TYR GLU GLU LYS GLN VAL ALA ARG GLY GLY GLY GLY SEQRES 62 C 936 GLY SER GLY CYS TYR THR GLU ASP TYR SER VAL SER VAL SEQRES 63 C 936 GLN TYR THR LEU THR GLU GLU PRO PRO PRO GLY CYS TYR SEQRES 64 C 936 PRO GLY ALA ARG ASP LEU SER GLN ARG ILE PRO ILE ILE SEQRES 65 C 936 PRO GLU ASP VAL ASP CYS ASP LEU GLY LEU PRO SER ASP SEQRES 66 C 936 CYS GLN GLY THR HIS SER LEU GLY SER TRP GLY GLY THR SEQRES 67 C 936 ARG GLY PRO ASP THR PRO ARG PRO HIS ARG GLY LEU GLY SEQRES 68 C 936 ALA THR ARG GLU GLU GLU ARG ALA LEU CYS CYS GLN ALA SEQRES 69 C 936 ARG ALA LEU LEU ARG PRO GLY CYS PRO PRO GLU GLU ALA SEQRES 70 C 936 GLY ALA VAL ARG ALA ASN PHE PRO SER ALA LEU GLN ASP SEQRES 71 C 936 THR GLN GLU SER SER THR THR ALA THR GLU ALA ALA GLY SEQRES 72 C 936 PRO ARG SER HIS SER ALA ASP SER SER SER PRO GLY ALA SEQRES 1 G 101 LYS GLY CYS LEU SER CYS SER LYS ASP ASN GLY CYS SER SEQRES 2 G 101 ARG CYS GLN GLN LYS LEU PHE PHE PHE LEU ARG ARG GLU SEQRES 3 G 101 GLY MET ARG GLN TYR GLY GLU CYS LEU HIS SER CYS PRO SEQRES 4 G 101 SER GLY TYR TYR GLY HIS ARG ALA PRO ASP MET ASN ARG SEQRES 5 G 101 CYS ALA ARG CYS ARG ILE GLU ASN CYS ASP SER CYS PHE SEQRES 6 G 101 SER LYS ASP PHE CYS THR LYS CYS LYS VAL GLY PHE TYR SEQRES 7 G 101 LEU HIS ARG GLY ARG CYS PHE ASP GLU CYS PRO ALA GLY SEQRES 8 G 101 PHE ALA PRO LEU ASP GLU THR MET GLU CYS SEQRES 1 H 936 MET ARG PRO ARG SER GLY GLY ARG PRO GLY ALA THR GLY SEQRES 2 H 936 ARG ARG ARG ARG ARG LEU ARG ARG ARG PRO ARG GLY LEU SEQRES 3 H 936 ARG CYS SER ARG LEU PRO PRO PRO PRO PRO LEU PRO LEU SEQRES 4 H 936 LEU LEU GLY LEU LEU LEU ALA ALA ALA GLY PRO GLY ALA SEQRES 5 H 936 ALA ARG ALA LYS GLU THR ALA PHE VAL GLU VAL VAL LEU SEQRES 6 H 936 PHE GLU SER SER PRO SER GLY ASP TYR THR THR TYR THR SEQRES 7 H 936 THR GLY LEU THR GLY ARG PHE SER ARG ALA GLY ALA THR SEQRES 8 H 936 LEU SER ALA GLU GLY GLU ILE VAL GLN MET HIS PRO LEU SEQRES 9 H 936 GLY LEU CYS ASN ASN ASN ASP GLU GLU ASP LEU TYR GLU SEQRES 10 H 936 TYR GLY TRP VAL GLY VAL VAL LYS LEU GLU GLN PRO GLU SEQRES 11 H 936 LEU ASP PRO LYS PRO CYS LEU THR VAL LEU GLY LYS ALA SEQRES 12 H 936 LYS ARG ALA VAL GLN ARG GLY ALA THR ALA VAL ILE PHE SEQRES 13 H 936 ASP VAL SER GLU ASN PRO GLU ALA ILE ASP GLN LEU ASN SEQRES 14 H 936 GLN GLY SER GLU ASP PRO LEU LYS ARG PRO VAL VAL TYR SEQRES 15 H 936 VAL LYS GLY ALA ASP ALA ILE LYS LEU MET ASN ILE VAL SEQRES 16 H 936 ASN LYS GLN LYS VAL ALA ARG ALA ARG ILE GLN HIS ARG SEQRES 17 H 936 PRO PRO ARG GLN PRO THR GLU TYR PHE ASP MET GLY ILE SEQRES 18 H 936 PHE LEU ALA PHE PHE VAL VAL VAL SER LEU VAL CYS LEU SEQRES 19 H 936 ILE LEU LEU VAL LYS ILE LYS LEU LYS GLN ARG ARG SER SEQRES 20 H 936 GLN ASN SER MET ASN ARG LEU ALA VAL GLN ALA LEU GLU SEQRES 21 H 936 LYS MET GLU THR ARG LYS PHE ASN SER LYS SER LYS GLY SEQRES 22 H 936 ARG ARG GLU GLY SER CYS GLY ALA LEU ASP THR LEU SER SEQRES 23 H 936 SER SER SER THR SER ASP CYS ALA ILE CYS LEU GLU LYS SEQRES 24 H 936 TYR ILE ASP GLY GLU GLU LEU ARG VAL ILE PRO CYS THR SEQRES 25 H 936 HIS ARG PHE HIS ARG LYS CYS VAL ASP PRO TRP LEU LEU SEQRES 26 H 936 GLN HIS HIS THR CYS PRO HIS CYS ARG HIS ASN ILE ILE SEQRES 27 H 936 GLU GLN LYS GLY ASN PRO SER ALA VAL CYS VAL GLU THR SEQRES 28 H 936 SER ASN LEU SER ARG GLY ARG GLN GLN ARG VAL THR LEU SEQRES 29 H 936 PRO VAL HIS TYR PRO GLY ARG VAL HIS ARG THR ASN ALA SEQRES 30 H 936 ILE PRO ALA TYR PRO THR ARG THR SER MET ASP SER HIS SEQRES 31 H 936 GLY ASN PRO VAL THR LEU LEU THR MET ASP ARG HIS GLY SEQRES 32 H 936 GLU GLN SER LEU TYR SER PRO GLN THR PRO ALA TYR ILE SEQRES 33 H 936 ARG SER TYR PRO PRO LEU HIS LEU ASP HIS SER LEU ALA SEQRES 34 H 936 ALA HIS ARG CYS GLY LEU GLU HIS ARG ALA TYR SER PRO SEQRES 35 H 936 ALA HIS PRO PHE ARG ARG PRO LYS LEU SER GLY ARG SER SEQRES 36 H 936 PHE SER LYS ALA ALA CYS PHE SER GLN TYR GLU THR MET SEQRES 37 H 936 TYR GLN HIS TYR TYR PHE GLN GLY LEU SER TYR PRO GLU SEQRES 38 H 936 GLN GLU GLY GLN SER PRO PRO SER LEU ALA PRO ARG GLY SEQRES 39 H 936 PRO ALA ARG ALA PHE PRO PRO SER GLY SER GLY SER LEU SEQRES 40 H 936 LEU PHE PRO THR VAL VAL HIS VAL ALA PRO PRO SER HIS SEQRES 41 H 936 LEU GLU SER GLY SER THR SER SER PHE SER CYS TYR HIS SEQRES 42 H 936 GLY HIS ARG SER VAL CYS SER GLY TYR LEU ALA ASP CYS SEQRES 43 H 936 PRO GLY SER ASP SER SER SER SER SER SER SER GLY GLN SEQRES 44 H 936 CYS HIS CYS SER SER SER ASP SER VAL VAL ASP CYS THR SEQRES 45 H 936 GLU VAL SER ASN GLN GLY VAL TYR GLY SER CYS SER THR SEQRES 46 H 936 PHE ARG SER SER LEU SER SER ASP TYR ASP PRO PHE ILE SEQRES 47 H 936 TYR ARG SER ARG SER PRO CYS ARG ALA SER GLU ALA GLY SEQRES 48 H 936 GLY SER GLY SER SER GLY ARG GLY PRO ALA LEU CYS PHE SEQRES 49 H 936 GLU GLY SER PRO PRO PRO GLU GLU LEU PRO ALA VAL HIS SEQRES 50 H 936 SER HIS GLY ALA GLY ARG GLY GLU PRO TRP PRO GLY PRO SEQRES 51 H 936 ALA SER PRO SER GLY ASP GLN VAL SER THR CYS SER LEU SEQRES 52 H 936 GLU MET ASN TYR SER SER ASN SER SER LEU GLU HIS ARG SEQRES 53 H 936 GLY PRO ASN SER SER THR SER GLU VAL GLY LEU GLU ALA SEQRES 54 H 936 SER PRO GLY ALA ALA PRO ASP LEU ARG ARG THR TRP LYS SEQRES 55 H 936 GLY GLY HIS GLU LEU PRO SER CYS ALA CYS CYS CYS GLU SEQRES 56 H 936 PRO GLN PRO SER PRO ALA GLY PRO SER ALA GLY ALA ALA SEQRES 57 H 936 GLY SER SER THR LEU PHE LEU GLY PRO HIS LEU TYR GLU SEQRES 58 H 936 GLY SER GLY PRO ALA GLY GLY GLU PRO GLN SER GLY SER SEQRES 59 H 936 SER GLN GLY LEU TYR GLY LEU HIS PRO ASP HIS LEU PRO SEQRES 60 H 936 ARG THR ASP GLY VAL LYS TYR GLU GLY LEU PRO CYS CYS SEQRES 61 H 936 PHE TYR GLU GLU LYS GLN VAL ALA ARG GLY GLY GLY GLY SEQRES 62 H 936 GLY SER GLY CYS TYR THR GLU ASP TYR SER VAL SER VAL SEQRES 63 H 936 GLN TYR THR LEU THR GLU GLU PRO PRO PRO GLY CYS TYR SEQRES 64 H 936 PRO GLY ALA ARG ASP LEU SER GLN ARG ILE PRO ILE ILE SEQRES 65 H 936 PRO GLU ASP VAL ASP CYS ASP LEU GLY LEU PRO SER ASP SEQRES 66 H 936 CYS GLN GLY THR HIS SER LEU GLY SER TRP GLY GLY THR SEQRES 67 H 936 ARG GLY PRO ASP THR PRO ARG PRO HIS ARG GLY LEU GLY SEQRES 68 H 936 ALA THR ARG GLU GLU GLU ARG ALA LEU CYS CYS GLN ALA SEQRES 69 H 936 ARG ALA LEU LEU ARG PRO GLY CYS PRO PRO GLU GLU ALA SEQRES 70 H 936 GLY ALA VAL ARG ALA ASN PHE PRO SER ALA LEU GLN ASP SEQRES 71 H 936 THR GLN GLU SER SER THR THR ALA THR GLU ALA ALA GLY SEQRES 72 H 936 PRO ARG SER HIS SER ALA ASP SER SER SER PRO GLY ALA SEQRES 1 J 101 LYS GLY CYS LEU SER CYS SER LYS ASP ASN GLY CYS SER SEQRES 2 J 101 ARG CYS GLN GLN LYS LEU PHE PHE PHE LEU ARG ARG GLU SEQRES 3 J 101 GLY MET ARG GLN TYR GLY GLU CYS LEU HIS SER CYS PRO SEQRES 4 J 101 SER GLY TYR TYR GLY HIS ARG ALA PRO ASP MET ASN ARG SEQRES 5 J 101 CYS ALA ARG CYS ARG ILE GLU ASN CYS ASP SER CYS PHE SEQRES 6 J 101 SER LYS ASP PHE CYS THR LYS CYS LYS VAL GLY PHE TYR SEQRES 7 J 101 LEU HIS ARG GLY ARG CYS PHE ASP GLU CYS PRO ALA GLY SEQRES 8 J 101 PHE ALA PRO LEU ASP GLU THR MET GLU CYS HELIX 1 AA1 PRO A 169 SER A 174 1 6 HELIX 2 AA2 GLN A 242 LEU A 247 5 6 HELIX 3 AA3 PRO A 335 CYS A 339 5 5 HELIX 4 AA4 TYR A 468 ALA A 472 5 5 HELIX 5 AA5 SER A 538 CYS A 567 1 30 HELIX 6 AA6 PRO A 571 SER A 601 1 31 HELIX 7 AA7 ARG A 604 GLY A 615 1 12 HELIX 8 AA8 GLY A 615 ASP A 649 1 35 HELIX 9 AA9 HIS A 658 HIS A 683 1 26 HELIX 10 AB1 GLU A 686 SER A 690 5 5 HELIX 11 AB2 LEU A 694 GLY A 699 1 6 HELIX 12 AB3 SER A 703 LEU A 732 1 30 HELIX 13 AB4 SER A 743 ALA A 769 1 27 HELIX 14 AB5 SER A 778 PHE A 790 1 13 HELIX 15 AB6 PRO A 791 PHE A 804 1 14 HELIX 16 AB7 ASN A 805 THR A 820 1 16 HELIX 17 AB8 LYS E 511 THR E 515 5 5 HELIX 18 AB9 HIS C 102 LEU C 106 5 5 HELIX 19 AC1 THR C 138 ARG C 149 1 12 HELIX 20 AC2 PRO C 162 GLY C 171 1 10 HELIX 21 AC3 SER C 172 ASP C 174 5 3 HELIX 22 AC4 GLY C 185 GLN C 198 1 14 HELIX 23 AC5 PRO C 213 GLY C 220 1 8 HELIX 24 AC6 ILE C 221 VAL C 227 1 7 HELIX 25 AC7 VAL C 227 LYS C 239 1 13 HELIX 26 AC8 HIS H 102 LEU H 106 5 5 HELIX 27 AC9 GLN H 128 ASP H 132 5 5 HELIX 28 AD1 THR H 138 ARG H 149 1 12 HELIX 29 AD2 PRO H 162 GLY H 171 1 10 HELIX 30 AD3 SER H 172 ASP H 174 5 3 HELIX 31 AD4 GLY H 185 GLN H 198 1 14 SHEET 1 AA111 ARG A 40 ASP A 42 0 SHEET 2 AA111 ALA A 61 ASP A 63 1 O ASP A 63 N VAL A 41 SHEET 3 AA111 GLU A 85 GLN A 87 1 O GLU A 85 N LEU A 62 SHEET 4 AA111 VAL A 109 THR A 111 1 O VAL A 109 N LEU A 86 SHEET 5 AA111 SER A 133 ARG A 135 1 O SER A 133 N LEU A 110 SHEET 6 AA111 HIS A 157 TRP A 159 1 O HIS A 157 N LEU A 134 SHEET 7 AA111 ALA A 181 THR A 183 1 O ALA A 181 N LEU A 158 SHEET 8 AA111 VAL A 205 HIS A 207 1 O VAL A 205 N LEU A 182 SHEET 9 AA111 THR A 229 ASP A 231 1 O THR A 229 N LEU A 206 SHEET 10 AA111 GLU A 252 GLY A 254 1 O GLU A 252 N LEU A 230 SHEET 11 AA111 THR A 276 HIS A 278 1 O THR A 276 N LEU A 253 SHEET 1 AA2 2 SER A 191 ILE A 192 0 SHEET 2 AA2 2 SER A 215 LEU A 216 1 O SER A 215 N ILE A 192 SHEET 1 AA3 9 SER A 300 ILE A 303 0 SHEET 2 AA3 9 SER A 323 LEU A 326 1 O THR A 325 N ILE A 303 SHEET 3 AA3 9 THR A 347 ASP A 349 1 O ASP A 349 N LEU A 324 SHEET 4 AA3 9 GLU A 369 SER A 371 1 O SER A 371 N LEU A 348 SHEET 5 AA3 9 ILE A 393 ASP A 395 1 O ASP A 395 N ILE A 370 SHEET 6 AA3 9 ASN A 417 ASP A 419 1 O ASP A 419 N LEU A 394 SHEET 7 AA3 9 GLN A 438 LYS A 440 1 O LYS A 440 N LEU A 418 SHEET 8 AA3 9 SER A 461 SER A 463 1 O SER A 461 N LEU A 439 SHEET 9 AA3 9 HIS A 521 CYS A 522 1 O HIS A 521 N LEU A 462 SHEET 1 AA4 2 GLN A 379 ILE A 380 0 SHEET 2 AA4 2 GLU A 403 ILE A 404 1 O GLU A 403 N ILE A 380 SHEET 1 AA5 4 VAL E 24 SER E 26 0 SHEET 2 AA5 4 ARG E 444 ALA E 448 -1 O SER E 446 N SER E 26 SHEET 3 AA5 4 THR E 502 MET E 507 -1 O LEU E 505 N LEU E 445 SHEET 4 AA5 4 PHE E 492 ASP E 497 -1 N SER E 495 O TYR E 504 SHEET 1 AA6 5 THR E 482 TYR E 484 0 SHEET 2 AA6 5 ARG E 470 VAL E 476 -1 N THR E 475 O ILE E 483 SHEET 3 AA6 5 TYR E 457 GLN E 464 -1 N TRP E 461 O ALA E 474 SHEET 4 AA6 5 ALA E 516 ARG E 523 -1 O TYR E 519 N PHE E 462 SHEET 5 AA6 5 TYR E 539 TRP E 540 -1 O TYR E 539 N SER E 522 SHEET 1 AA7 5 THR E 482 TYR E 484 0 SHEET 2 AA7 5 ARG E 470 VAL E 476 -1 N THR E 475 O ILE E 483 SHEET 3 AA7 5 TYR E 457 GLN E 464 -1 N TRP E 461 O ALA E 474 SHEET 4 AA7 5 ALA E 516 ARG E 523 -1 O TYR E 519 N PHE E 462 SHEET 5 AA7 5 THR E 544 VAL E 546 -1 O THR E 544 N TYR E 518 SHEET 1 AA8 8 THR C 58 PHE C 66 0 SHEET 2 AA8 8 THR C 76 PHE C 85 -1 O TYR C 77 N LEU C 65 SHEET 3 AA8 8 VAL C 180 VAL C 183 -1 O TYR C 182 N ARG C 84 SHEET 4 AA8 8 ALA C 151 ASP C 157 1 N VAL C 154 O VAL C 181 SHEET 5 AA8 8 TRP C 120 LYS C 125 1 N GLY C 122 O ILE C 155 SHEET 6 AA8 8 ALA C 94 GLN C 100 1 N VAL C 99 O VAL C 121 SHEET 7 AA8 8 ARG C 202 GLN C 206 -1 O ALA C 203 N GLY C 96 SHEET 8 AA8 8 THR C 58 PHE C 66 -1 N PHE C 60 O GLN C 206 SHEET 1 AA9 2 PHE G 60 GLU G 66 0 SHEET 2 AA9 2 ARG G 69 LEU G 75 -1 O GLU G 73 N PHE G 62 SHEET 1 AB1 2 TYR G 82 HIS G 85 0 SHEET 2 AB1 2 ARG G 92 ARG G 95 -1 O ALA G 94 N TYR G 83 SHEET 1 AB2 2 CYS G 101 SER G 103 0 SHEET 2 AB2 2 LYS G 112 CYS G 113 -1 O LYS G 112 N SER G 103 SHEET 1 AB3 2 TYR G 118 LEU G 119 0 SHEET 2 AB3 2 CYS G 124 PHE G 125 -1 O PHE G 125 N TYR G 118 SHEET 1 AB4 8 THR H 58 PHE H 66 0 SHEET 2 AB4 8 THR H 76 PHE H 85 -1 O THR H 79 N VAL H 63 SHEET 3 AB4 8 VAL H 180 VAL H 183 -1 O TYR H 182 N ARG H 84 SHEET 4 AB4 8 VAL H 154 ASP H 157 1 N VAL H 154 O VAL H 181 SHEET 5 AB4 8 VAL H 121 LYS H 125 1 N GLY H 122 O ILE H 155 SHEET 6 AB4 8 ALA H 94 MET H 101 1 N MET H 101 O VAL H 123 SHEET 7 AB4 8 ARG H 202 GLN H 206 -1 O ILE H 205 N ALA H 94 SHEET 8 AB4 8 THR H 58 PHE H 66 -1 N GLU H 62 O ARG H 204 SHEET 1 AB5 4 ARG J 69 LEU J 75 0 SHEET 2 AB5 4 PHE J 60 GLU J 66 -1 N PHE J 60 O LEU J 75 SHEET 3 AB5 4 ASN J 91 ARG J 95 1 O ASN J 91 N PHE J 61 SHEET 4 AB5 4 TYR J 82 HIS J 85 -1 N TYR J 83 O ALA J 94 SHEET 1 AB6 2 CYS J 101 SER J 106 0 SHEET 2 AB6 2 PHE J 109 CYS J 113 -1 O PHE J 109 N PHE J 105 SHEET 1 AB7 2 TYR J 118 LEU J 119 0 SHEET 2 AB7 2 CYS J 124 PHE J 125 -1 O PHE J 125 N TYR J 118 SSBOND 1 CYS A 33 CYS A 43 1555 1555 2.03 SSBOND 2 CYS A 339 CYS A 364 1555 1555 2.03 SSBOND 3 CYS A 618 CYS A 693 1555 1555 2.03 SSBOND 4 CYS E 447 CYS E 520 1555 1555 2.03 SSBOND 5 CYS C 107 CYS C 136 1555 1555 2.03 SSBOND 6 CYS G 46 CYS G 52 1555 1555 2.03 SSBOND 7 CYS G 55 CYS G 74 1555 1555 2.03 SSBOND 8 CYS G 78 CYS G 93 1555 1555 2.03 SSBOND 9 CYS G 101 CYS G 110 1555 1555 2.03 SSBOND 10 CYS G 113 CYS G 124 1555 1555 2.03 SSBOND 11 CYS G 128 CYS G 141 1555 1555 2.03 SSBOND 12 CYS H 107 CYS H 136 1555 1555 2.03 SSBOND 13 CYS J 43 CYS J 74 1555 1555 2.03 SSBOND 14 CYS J 46 CYS J 52 1555 1555 2.03 SSBOND 15 CYS J 55 CYS J 74 1555 1555 2.03 SSBOND 16 CYS J 78 CYS J 93 1555 1555 2.03 SSBOND 17 CYS J 101 CYS J 110 1555 1555 2.03 SSBOND 18 CYS J 113 CYS J 124 1555 1555 2.03 SSBOND 19 CYS J 128 CYS J 141 1555 1555 2.03 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000