HEADER MEMBRANE PROTEIN/IMMUNE SYSTEM 26-DEC-23 8XLK TITLE STRUCTURE OF NATIVE TRI-HETEROMERIC GLUN1-GLUN2A-GLUN2B NMDA RECEPTOR TITLE 2 IN RAT CORTEX AND HIPPOCAMPUS COMPND MOL_ID: 1; COMPND 2 MOLECULE: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1; COMPND 3 CHAIN: A, C; COMPND 4 SYNONYM: GLUN1,GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA-1,N-METHYL-D- COMPND 5 ASPARTATE RECEPTOR SUBUNIT NR1,NMD-R1; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A; COMPND 8 CHAIN: B; COMPND 9 SYNONYM: GLUN2A,GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-1,N-METHYL COMPND 10 D-ASPARTATE RECEPTOR SUBTYPE 2A,NMDAR2A,NR2A; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B; COMPND 13 CHAIN: D; COMPND 14 SYNONYM: GLUN2B,GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2,N-METHYL COMPND 15 D-ASPARTATE RECEPTOR SUBTYPE 2B,NMDAR2B,NR2B; COMPND 16 MOL_ID: 4; COMPND 17 MOLECULE: HEAVY CHAIN OF GLUN1 FAB, 4F11; COMPND 18 CHAIN: E, I; COMPND 19 ENGINEERED: YES; COMPND 20 MOL_ID: 5; COMPND 21 MOLECULE: LIGHT CHAIN OF GLUN1 FAB, 4F11; COMPND 22 CHAIN: F, J; COMPND 23 ENGINEERED: YES; COMPND 24 MOL_ID: 6; COMPND 25 MOLECULE: HEAVY CHAIN OF GLUN2A FAB, 28C; COMPND 26 CHAIN: G; COMPND 27 MOL_ID: 7; COMPND 28 MOLECULE: LIGHT CHAIN OF GLUN2A FAB, 28C; COMPND 29 CHAIN: H; COMPND 30 MOL_ID: 8; COMPND 31 MOLECULE: HEAVY CHAIN OF GLUN2B FAB2; COMPND 32 CHAIN: K; COMPND 33 ENGINEERED: YES; COMPND 34 MOL_ID: 9; COMPND 35 MOLECULE: LIGHT CHAIN OF GLUN2B FAB2; COMPND 36 CHAIN: L; COMPND 37 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; SOURCE 3 ORGANISM_COMMON: NORWAY RAT; SOURCE 4 ORGANISM_TAXID: 10116; SOURCE 5 STRAIN: WISTAR; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; SOURCE 8 ORGANISM_COMMON: NORWAY RAT; SOURCE 9 ORGANISM_TAXID: 10116; SOURCE 10 STRAIN: WISTAR; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; SOURCE 13 ORGANISM_COMMON: NORWAY RAT; SOURCE 14 ORGANISM_TAXID: 10116; SOURCE 15 STRAIN: WISTAR; SOURCE 16 MOL_ID: 4; SOURCE 17 ORGANISM_SCIENTIFIC: MUS MUSCULOIDES; SOURCE 18 ORGANISM_TAXID: 60742; SOURCE 19 EXPRESSION_SYSTEM: TRICHOPLUSIA NI; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 7111; SOURCE 21 MOL_ID: 5; SOURCE 22 ORGANISM_SCIENTIFIC: MUS MUSCULOIDES; SOURCE 23 ORGANISM_TAXID: 60742; SOURCE 24 EXPRESSION_SYSTEM: TRICHOPLUSIA NI; SOURCE 25 EXPRESSION_SYSTEM_TAXID: 7111; SOURCE 26 MOL_ID: 6; SOURCE 27 ORGANISM_SCIENTIFIC: MUS MUSCULOIDES; SOURCE 28 ORGANISM_TAXID: 60742; SOURCE 29 MOL_ID: 7; SOURCE 30 ORGANISM_SCIENTIFIC: MUS MUSCULOIDES; SOURCE 31 ORGANISM_TAXID: 60742; SOURCE 32 MOL_ID: 8; SOURCE 33 ORGANISM_SCIENTIFIC: MUS MUSCULOIDES; SOURCE 34 ORGANISM_TAXID: 60742; SOURCE 35 EXPRESSION_SYSTEM: TRICHOPLUSIA NI; SOURCE 36 EXPRESSION_SYSTEM_TAXID: 7111; SOURCE 37 MOL_ID: 9; SOURCE 38 ORGANISM_SCIENTIFIC: MUS MUSCULOIDES; SOURCE 39 ORGANISM_TAXID: 60742; SOURCE 40 EXPRESSION_SYSTEM: TRICHOPLUSIA NI; SOURCE 41 EXPRESSION_SYSTEM_TAXID: 7111 KEYWDS MEMBRANE PROTEIN, NATIVE NMDA RECEPTOR, ADULT RAT CARTEX & KEYWDS 2 HIPPOCAMPUS, GLUN2A, GLUN2B, MEMBRANE PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR M.ZHANG,J.FENG,Y.LI,S.ZHU REVDAT 1 05-FEB-25 8XLK 0 JRNL AUTH M.ZHANG,J.FENG,C.XIE,N.SONG,C.JIN,J.WANG,Q.ZHAO,L.ZHANG, JRNL AUTH 2 B.WANG,Y.SUN,F.GUO,Y.LI,S.ZHU JRNL TITL ASSEMBLY AND ARCHITECTURE OF ENDOGENOUS NMDA RECEPTORS IN JRNL TITL 2 ADULT CEREBRAL CORTEX AND HIPPOCAMPUS. JRNL REF CELL 2025 JRNL REFN ISSN 1097-4172 JRNL PMID 39855198 JRNL DOI 10.1016/J.CELL.2025.01.004 REMARK 2 REMARK 2 RESOLUTION. 4.20 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.200 REMARK 3 NUMBER OF PARTICLES : 45676 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8XLK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 26-DEC-23. REMARK 100 THE DEPOSITION ID IS D_1300042906. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : TISSUE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : NATIVE TRI-HETEROMERIC GLUN1 REMARK 245 -GLUN2A-GLUN2B NMDA RECEPTOR IN REMARK 245 RAT CORTEX AND HIPPOCAMPUS; REMARK 245 NMDA RECEPTOR; FAB 4F11; FAB REMARK 245 28C; FAB2; FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI POLARA 300 REMARK 245 DETECTOR TYPE : DIRECT ELECTRON DE-10 (5K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 SER A 2 REMARK 465 THR A 3 REMARK 465 MET A 4 REMARK 465 HIS A 5 REMARK 465 LEU A 6 REMARK 465 LEU A 7 REMARK 465 THR A 8 REMARK 465 PHE A 9 REMARK 465 ALA A 10 REMARK 465 LEU A 11 REMARK 465 LEU A 12 REMARK 465 PHE A 13 REMARK 465 SER A 14 REMARK 465 CYS A 15 REMARK 465 SER A 16 REMARK 465 PHE A 17 REMARK 465 ALA A 18 REMARK 465 ARG A 19 REMARK 465 ALA A 20 REMARK 465 ALA A 21 REMARK 465 CYS A 22 REMARK 465 ASP A 23 REMARK 465 PRO A 24 REMARK 465 PRO A 585 REMARK 465 PHE A 586 REMARK 465 GLY A 587 REMARK 465 ARG A 588 REMARK 465 PHE A 589 REMARK 465 LYS A 590 REMARK 465 VAL A 591 REMARK 465 ASN A 592 REMARK 465 SER A 593 REMARK 465 GLU A 594 REMARK 465 GLU A 595 REMARK 465 GLU A 596 REMARK 465 GLU A 597 REMARK 465 GLU A 598 REMARK 465 ASP A 599 REMARK 465 ALA A 600 REMARK 465 LEU A 601 REMARK 465 ASP A 842 REMARK 465 ALA A 843 REMARK 465 ARG A 844 REMARK 465 ARG A 845 REMARK 465 LYS A 846 REMARK 465 GLN A 847 REMARK 465 MET A 848 REMARK 465 GLN A 849 REMARK 465 LEU A 850 REMARK 465 ALA A 851 REMARK 465 PHE A 852 REMARK 465 ALA A 853 REMARK 465 ALA A 854 REMARK 465 VAL A 855 REMARK 465 ASN A 856 REMARK 465 VAL A 857 REMARK 465 TRP A 858 REMARK 465 ARG A 859 REMARK 465 LYS A 860 REMARK 465 ASN A 861 REMARK 465 LEU A 862 REMARK 465 GLN A 863 REMARK 465 ASP A 864 REMARK 465 ARG A 865 REMARK 465 LYS A 866 REMARK 465 SER A 867 REMARK 465 GLY A 868 REMARK 465 ARG A 869 REMARK 465 ALA A 870 REMARK 465 GLU A 871 REMARK 465 PRO A 872 REMARK 465 ASP A 873 REMARK 465 PRO A 874 REMARK 465 LYS A 875 REMARK 465 LYS A 876 REMARK 465 LYS A 877 REMARK 465 ALA A 878 REMARK 465 THR A 879 REMARK 465 PHE A 880 REMARK 465 ARG A 881 REMARK 465 ALA A 882 REMARK 465 ILE A 883 REMARK 465 THR A 884 REMARK 465 SER A 885 REMARK 465 THR A 886 REMARK 465 LEU A 887 REMARK 465 ALA A 888 REMARK 465 SER A 889 REMARK 465 SER A 890 REMARK 465 PHE A 891 REMARK 465 LYS A 892 REMARK 465 ARG A 893 REMARK 465 ARG A 894 REMARK 465 ARG A 895 REMARK 465 SER A 896 REMARK 465 SER A 897 REMARK 465 LYS A 898 REMARK 465 ASP A 899 REMARK 465 THR A 900 REMARK 465 SER A 901 REMARK 465 THR A 902 REMARK 465 GLY A 903 REMARK 465 GLY A 904 REMARK 465 GLY A 905 REMARK 465 ARG A 906 REMARK 465 GLY A 907 REMARK 465 ALA A 908 REMARK 465 LEU A 909 REMARK 465 GLN A 910 REMARK 465 ASN A 911 REMARK 465 GLN A 912 REMARK 465 LYS A 913 REMARK 465 ASP A 914 REMARK 465 THR A 915 REMARK 465 VAL A 916 REMARK 465 LEU A 917 REMARK 465 PRO A 918 REMARK 465 ARG A 919 REMARK 465 ARG A 920 REMARK 465 ALA A 921 REMARK 465 ILE A 922 REMARK 465 GLU A 923 REMARK 465 ARG A 924 REMARK 465 GLU A 925 REMARK 465 GLU A 926 REMARK 465 GLY A 927 REMARK 465 GLN A 928 REMARK 465 LEU A 929 REMARK 465 GLN A 930 REMARK 465 LEU A 931 REMARK 465 CYS A 932 REMARK 465 SER A 933 REMARK 465 ARG A 934 REMARK 465 HIS A 935 REMARK 465 ARG A 936 REMARK 465 GLU A 937 REMARK 465 SER A 938 REMARK 465 MET B 1 REMARK 465 GLY B 2 REMARK 465 ARG B 3 REMARK 465 LEU B 4 REMARK 465 GLY B 5 REMARK 465 TYR B 6 REMARK 465 TRP B 7 REMARK 465 THR B 8 REMARK 465 LEU B 9 REMARK 465 LEU B 10 REMARK 465 VAL B 11 REMARK 465 LEU B 12 REMARK 465 PRO B 13 REMARK 465 ALA B 14 REMARK 465 LEU B 15 REMARK 465 LEU B 16 REMARK 465 VAL B 17 REMARK 465 TRP B 18 REMARK 465 ARG B 19 REMARK 465 ASP B 20 REMARK 465 PRO B 21 REMARK 465 ALA B 22 REMARK 465 GLN B 23 REMARK 465 ASN B 24 REMARK 465 ALA B 25 REMARK 465 ALA B 26 REMARK 465 ALA B 27 REMARK 465 GLU B 28 REMARK 465 LYS B 29 REMARK 465 GLY B 30 REMARK 465 PRO B 31 REMARK 465 PRO B 32 REMARK 465 ALA B 33 REMARK 465 SER B 580 REMARK 465 PRO B 581 REMARK 465 VAL B 582 REMARK 465 GLY B 583 REMARK 465 TYR B 584 REMARK 465 ASN B 585 REMARK 465 ARG B 586 REMARK 465 ASN B 587 REMARK 465 LEU B 588 REMARK 465 ALA B 589 REMARK 465 LYS B 590 REMARK 465 GLY B 591 REMARK 465 LYS B 592 REMARK 465 ALA B 593 REMARK 465 PRO B 594 REMARK 465 HIS B 595 REMARK 465 GLY B 596 REMARK 465 PRO B 597 REMARK 465 SER B 598 REMARK 465 LEU B 845 REMARK 465 ARG B 846 REMARK 465 PHE B 847 REMARK 465 CYS B 848 REMARK 465 PHE B 849 REMARK 465 THR B 850 REMARK 465 GLY B 851 REMARK 465 VAL B 852 REMARK 465 CYS B 853 REMARK 465 SER B 854 REMARK 465 ASP B 855 REMARK 465 ARG B 856 REMARK 465 PRO B 857 REMARK 465 GLY B 858 REMARK 465 LEU B 859 REMARK 465 LEU B 860 REMARK 465 PHE B 861 REMARK 465 SER B 862 REMARK 465 ILE B 863 REMARK 465 SER B 864 REMARK 465 ARG B 865 REMARK 465 GLY B 866 REMARK 465 ILE B 867 REMARK 465 TYR B 868 REMARK 465 SER B 869 REMARK 465 CYS B 870 REMARK 465 ILE B 871 REMARK 465 HIS B 872 REMARK 465 GLY B 873 REMARK 465 VAL B 874 REMARK 465 HIS B 875 REMARK 465 ILE B 876 REMARK 465 GLU B 877 REMARK 465 GLU B 878 REMARK 465 LYS B 879 REMARK 465 LYS B 880 REMARK 465 LYS B 881 REMARK 465 SER B 882 REMARK 465 PRO B 883 REMARK 465 ASP B 884 REMARK 465 PHE B 885 REMARK 465 ASN B 886 REMARK 465 LEU B 887 REMARK 465 THR B 888 REMARK 465 GLY B 889 REMARK 465 SER B 890 REMARK 465 GLN B 891 REMARK 465 SER B 892 REMARK 465 ASN B 893 REMARK 465 MET B 894 REMARK 465 LEU B 895 REMARK 465 LYS B 896 REMARK 465 LEU B 897 REMARK 465 LEU B 898 REMARK 465 ARG B 899 REMARK 465 SER B 900 REMARK 465 ALA B 901 REMARK 465 LYS B 902 REMARK 465 ASN B 903 REMARK 465 ILE B 904 REMARK 465 SER B 905 REMARK 465 ASN B 906 REMARK 465 MET B 907 REMARK 465 SER B 908 REMARK 465 ASN B 909 REMARK 465 MET B 910 REMARK 465 ASN B 911 REMARK 465 SER B 912 REMARK 465 SER B 913 REMARK 465 ARG B 914 REMARK 465 MET B 915 REMARK 465 ASP B 916 REMARK 465 SER B 917 REMARK 465 PRO B 918 REMARK 465 LYS B 919 REMARK 465 ARG B 920 REMARK 465 ALA B 921 REMARK 465 THR B 922 REMARK 465 ASP B 923 REMARK 465 PHE B 924 REMARK 465 ILE B 925 REMARK 465 GLN B 926 REMARK 465 ARG B 927 REMARK 465 GLY B 928 REMARK 465 SER B 929 REMARK 465 LEU B 930 REMARK 465 ILE B 931 REMARK 465 VAL B 932 REMARK 465 ASP B 933 REMARK 465 MET B 934 REMARK 465 VAL B 935 REMARK 465 SER B 936 REMARK 465 ASP B 937 REMARK 465 LYS B 938 REMARK 465 GLY B 939 REMARK 465 ASN B 940 REMARK 465 LEU B 941 REMARK 465 ILE B 942 REMARK 465 TYR B 943 REMARK 465 SER B 944 REMARK 465 ASP B 945 REMARK 465 ASN B 946 REMARK 465 ARG B 947 REMARK 465 SER B 948 REMARK 465 PHE B 949 REMARK 465 GLN B 950 REMARK 465 GLY B 951 REMARK 465 LYS B 952 REMARK 465 ASP B 953 REMARK 465 SER B 954 REMARK 465 ILE B 955 REMARK 465 PHE B 956 REMARK 465 GLY B 957 REMARK 465 ASP B 958 REMARK 465 ASN B 959 REMARK 465 MET B 960 REMARK 465 ASN B 961 REMARK 465 GLU B 962 REMARK 465 LEU B 963 REMARK 465 GLN B 964 REMARK 465 THR B 965 REMARK 465 PHE B 966 REMARK 465 VAL B 967 REMARK 465 ALA B 968 REMARK 465 ASN B 969 REMARK 465 ARG B 970 REMARK 465 HIS B 971 REMARK 465 LYS B 972 REMARK 465 ASP B 973 REMARK 465 ASN B 974 REMARK 465 LEU B 975 REMARK 465 SER B 976 REMARK 465 ASN B 977 REMARK 465 TYR B 978 REMARK 465 VAL B 979 REMARK 465 PHE B 980 REMARK 465 GLN B 981 REMARK 465 GLY B 982 REMARK 465 GLN B 983 REMARK 465 HIS B 984 REMARK 465 PRO B 985 REMARK 465 LEU B 986 REMARK 465 THR B 987 REMARK 465 LEU B 988 REMARK 465 ASN B 989 REMARK 465 GLU B 990 REMARK 465 SER B 991 REMARK 465 ASN B 992 REMARK 465 PRO B 993 REMARK 465 ASN B 994 REMARK 465 THR B 995 REMARK 465 VAL B 996 REMARK 465 GLU B 997 REMARK 465 VAL B 998 REMARK 465 ALA B 999 REMARK 465 VAL B 1000 REMARK 465 SER B 1001 REMARK 465 THR B 1002 REMARK 465 GLU B 1003 REMARK 465 SER B 1004 REMARK 465 LYS B 1005 REMARK 465 GLY B 1006 REMARK 465 ASN B 1007 REMARK 465 SER B 1008 REMARK 465 ARG B 1009 REMARK 465 PRO B 1010 REMARK 465 ARG B 1011 REMARK 465 GLN B 1012 REMARK 465 LEU B 1013 REMARK 465 TRP B 1014 REMARK 465 LYS B 1015 REMARK 465 LYS B 1016 REMARK 465 SER B 1017 REMARK 465 MET B 1018 REMARK 465 GLU B 1019 REMARK 465 SER B 1020 REMARK 465 LEU B 1021 REMARK 465 ARG B 1022 REMARK 465 GLN B 1023 REMARK 465 ASP B 1024 REMARK 465 SER B 1025 REMARK 465 LEU B 1026 REMARK 465 ASN B 1027 REMARK 465 GLN B 1028 REMARK 465 ASN B 1029 REMARK 465 PRO B 1030 REMARK 465 VAL B 1031 REMARK 465 SER B 1032 REMARK 465 GLN B 1033 REMARK 465 ARG B 1034 REMARK 465 ASP B 1035 REMARK 465 GLU B 1036 REMARK 465 LYS B 1037 REMARK 465 THR B 1038 REMARK 465 ALA B 1039 REMARK 465 GLU B 1040 REMARK 465 ASN B 1041 REMARK 465 ARG B 1042 REMARK 465 THR B 1043 REMARK 465 HIS B 1044 REMARK 465 SER B 1045 REMARK 465 LEU B 1046 REMARK 465 LYS B 1047 REMARK 465 SER B 1048 REMARK 465 PRO B 1049 REMARK 465 ARG B 1050 REMARK 465 TYR B 1051 REMARK 465 LEU B 1052 REMARK 465 PRO B 1053 REMARK 465 GLU B 1054 REMARK 465 GLU B 1055 REMARK 465 VAL B 1056 REMARK 465 ALA B 1057 REMARK 465 HIS B 1058 REMARK 465 SER B 1059 REMARK 465 ASP B 1060 REMARK 465 ILE B 1061 REMARK 465 SER B 1062 REMARK 465 GLU B 1063 REMARK 465 THR B 1064 REMARK 465 SER B 1065 REMARK 465 SER B 1066 REMARK 465 ARG B 1067 REMARK 465 ALA B 1068 REMARK 465 THR B 1069 REMARK 465 CYS B 1070 REMARK 465 HIS B 1071 REMARK 465 ARG B 1072 REMARK 465 GLU B 1073 REMARK 465 PRO B 1074 REMARK 465 ASP B 1075 REMARK 465 ASN B 1076 REMARK 465 ASN B 1077 REMARK 465 LYS B 1078 REMARK 465 ASN B 1079 REMARK 465 HIS B 1080 REMARK 465 LYS B 1081 REMARK 465 THR B 1082 REMARK 465 LYS B 1083 REMARK 465 ASP B 1084 REMARK 465 ASN B 1085 REMARK 465 PHE B 1086 REMARK 465 LYS B 1087 REMARK 465 ARG B 1088 REMARK 465 SER B 1089 REMARK 465 MET B 1090 REMARK 465 ALA B 1091 REMARK 465 SER B 1092 REMARK 465 LYS B 1093 REMARK 465 TYR B 1094 REMARK 465 PRO B 1095 REMARK 465 LYS B 1096 REMARK 465 ASP B 1097 REMARK 465 CYS B 1098 REMARK 465 SER B 1099 REMARK 465 ASP B 1100 REMARK 465 VAL B 1101 REMARK 465 ASP B 1102 REMARK 465 ARG B 1103 REMARK 465 THR B 1104 REMARK 465 TYR B 1105 REMARK 465 MET B 1106 REMARK 465 LYS B 1107 REMARK 465 THR B 1108 REMARK 465 LYS B 1109 REMARK 465 ALA B 1110 REMARK 465 SER B 1111 REMARK 465 SER B 1112 REMARK 465 PRO B 1113 REMARK 465 ARG B 1114 REMARK 465 ASP B 1115 REMARK 465 LYS B 1116 REMARK 465 ILE B 1117 REMARK 465 TYR B 1118 REMARK 465 THR B 1119 REMARK 465 ILE B 1120 REMARK 465 ASP B 1121 REMARK 465 GLY B 1122 REMARK 465 GLU B 1123 REMARK 465 LYS B 1124 REMARK 465 GLU B 1125 REMARK 465 PRO B 1126 REMARK 465 SER B 1127 REMARK 465 PHE B 1128 REMARK 465 HIS B 1129 REMARK 465 LEU B 1130 REMARK 465 ASP B 1131 REMARK 465 PRO B 1132 REMARK 465 PRO B 1133 REMARK 465 GLN B 1134 REMARK 465 PHE B 1135 REMARK 465 VAL B 1136 REMARK 465 GLU B 1137 REMARK 465 ASN B 1138 REMARK 465 ILE B 1139 REMARK 465 THR B 1140 REMARK 465 LEU B 1141 REMARK 465 PRO B 1142 REMARK 465 GLU B 1143 REMARK 465 ASN B 1144 REMARK 465 VAL B 1145 REMARK 465 GLY B 1146 REMARK 465 PHE B 1147 REMARK 465 PRO B 1148 REMARK 465 ASP B 1149 REMARK 465 THR B 1150 REMARK 465 TYR B 1151 REMARK 465 GLN B 1152 REMARK 465 ASP B 1153 REMARK 465 HIS B 1154 REMARK 465 ASN B 1155 REMARK 465 GLU B 1156 REMARK 465 ASN B 1157 REMARK 465 PHE B 1158 REMARK 465 ARG B 1159 REMARK 465 LYS B 1160 REMARK 465 GLY B 1161 REMARK 465 ASP B 1162 REMARK 465 SER B 1163 REMARK 465 THR B 1164 REMARK 465 LEU B 1165 REMARK 465 PRO B 1166 REMARK 465 MET B 1167 REMARK 465 ASN B 1168 REMARK 465 ARG B 1169 REMARK 465 ASN B 1170 REMARK 465 PRO B 1171 REMARK 465 LEU B 1172 REMARK 465 HIS B 1173 REMARK 465 ASN B 1174 REMARK 465 GLU B 1175 REMARK 465 ASP B 1176 REMARK 465 GLY B 1177 REMARK 465 LEU B 1178 REMARK 465 PRO B 1179 REMARK 465 ASN B 1180 REMARK 465 ASN B 1181 REMARK 465 ASP B 1182 REMARK 465 GLN B 1183 REMARK 465 TYR B 1184 REMARK 465 LYS B 1185 REMARK 465 LEU B 1186 REMARK 465 TYR B 1187 REMARK 465 ALA B 1188 REMARK 465 LYS B 1189 REMARK 465 HIS B 1190 REMARK 465 PHE B 1191 REMARK 465 THR B 1192 REMARK 465 LEU B 1193 REMARK 465 LYS B 1194 REMARK 465 ASP B 1195 REMARK 465 LYS B 1196 REMARK 465 GLY B 1197 REMARK 465 SER B 1198 REMARK 465 PRO B 1199 REMARK 465 HIS B 1200 REMARK 465 SER B 1201 REMARK 465 GLU B 1202 REMARK 465 GLY B 1203 REMARK 465 SER B 1204 REMARK 465 ASP B 1205 REMARK 465 ARG B 1206 REMARK 465 TYR B 1207 REMARK 465 ARG B 1208 REMARK 465 GLN B 1209 REMARK 465 ASN B 1210 REMARK 465 SER B 1211 REMARK 465 THR B 1212 REMARK 465 HIS B 1213 REMARK 465 CYS B 1214 REMARK 465 ARG B 1215 REMARK 465 SER B 1216 REMARK 465 CYS B 1217 REMARK 465 LEU B 1218 REMARK 465 SER B 1219 REMARK 465 ASN B 1220 REMARK 465 LEU B 1221 REMARK 465 PRO B 1222 REMARK 465 THR B 1223 REMARK 465 TYR B 1224 REMARK 465 SER B 1225 REMARK 465 GLY B 1226 REMARK 465 HIS B 1227 REMARK 465 PHE B 1228 REMARK 465 THR B 1229 REMARK 465 MET B 1230 REMARK 465 ARG B 1231 REMARK 465 SER B 1232 REMARK 465 PRO B 1233 REMARK 465 PHE B 1234 REMARK 465 LYS B 1235 REMARK 465 CYS B 1236 REMARK 465 ASP B 1237 REMARK 465 ALA B 1238 REMARK 465 CYS B 1239 REMARK 465 LEU B 1240 REMARK 465 ARG B 1241 REMARK 465 MET B 1242 REMARK 465 GLY B 1243 REMARK 465 ASN B 1244 REMARK 465 LEU B 1245 REMARK 465 TYR B 1246 REMARK 465 ASP B 1247 REMARK 465 ILE B 1248 REMARK 465 ASP B 1249 REMARK 465 GLU B 1250 REMARK 465 ASP B 1251 REMARK 465 GLN B 1252 REMARK 465 MET B 1253 REMARK 465 LEU B 1254 REMARK 465 GLN B 1255 REMARK 465 GLU B 1256 REMARK 465 THR B 1257 REMARK 465 GLY B 1258 REMARK 465 ASN B 1259 REMARK 465 PRO B 1260 REMARK 465 ALA B 1261 REMARK 465 THR B 1262 REMARK 465 ARG B 1263 REMARK 465 GLU B 1264 REMARK 465 GLU B 1265 REMARK 465 VAL B 1266 REMARK 465 TYR B 1267 REMARK 465 GLN B 1268 REMARK 465 GLN B 1269 REMARK 465 ASP B 1270 REMARK 465 TRP B 1271 REMARK 465 SER B 1272 REMARK 465 GLN B 1273 REMARK 465 ASN B 1274 REMARK 465 ASN B 1275 REMARK 465 ALA B 1276 REMARK 465 LEU B 1277 REMARK 465 GLN B 1278 REMARK 465 PHE B 1279 REMARK 465 GLN B 1280 REMARK 465 LYS B 1281 REMARK 465 ASN B 1282 REMARK 465 LYS B 1283 REMARK 465 LEU B 1284 REMARK 465 ARG B 1285 REMARK 465 ILE B 1286 REMARK 465 ASN B 1287 REMARK 465 ARG B 1288 REMARK 465 GLN B 1289 REMARK 465 HIS B 1290 REMARK 465 SER B 1291 REMARK 465 TYR B 1292 REMARK 465 ASP B 1293 REMARK 465 ASN B 1294 REMARK 465 ILE B 1295 REMARK 465 LEU B 1296 REMARK 465 ASP B 1297 REMARK 465 LYS B 1298 REMARK 465 PRO B 1299 REMARK 465 ARG B 1300 REMARK 465 GLU B 1301 REMARK 465 ILE B 1302 REMARK 465 ASP B 1303 REMARK 465 LEU B 1304 REMARK 465 SER B 1305 REMARK 465 ARG B 1306 REMARK 465 PRO B 1307 REMARK 465 SER B 1308 REMARK 465 ARG B 1309 REMARK 465 SER B 1310 REMARK 465 ILE B 1311 REMARK 465 SER B 1312 REMARK 465 LEU B 1313 REMARK 465 LYS B 1314 REMARK 465 ASP B 1315 REMARK 465 ARG B 1316 REMARK 465 GLU B 1317 REMARK 465 ARG B 1318 REMARK 465 LEU B 1319 REMARK 465 LEU B 1320 REMARK 465 GLU B 1321 REMARK 465 GLY B 1322 REMARK 465 ASN B 1323 REMARK 465 LEU B 1324 REMARK 465 TYR B 1325 REMARK 465 GLY B 1326 REMARK 465 SER B 1327 REMARK 465 LEU B 1328 REMARK 465 PHE B 1329 REMARK 465 SER B 1330 REMARK 465 VAL B 1331 REMARK 465 PRO B 1332 REMARK 465 SER B 1333 REMARK 465 SER B 1334 REMARK 465 LYS B 1335 REMARK 465 LEU B 1336 REMARK 465 LEU B 1337 REMARK 465 GLY B 1338 REMARK 465 ASN B 1339 REMARK 465 LYS B 1340 REMARK 465 SER B 1341 REMARK 465 SER B 1342 REMARK 465 LEU B 1343 REMARK 465 PHE B 1344 REMARK 465 PRO B 1345 REMARK 465 GLN B 1346 REMARK 465 GLY B 1347 REMARK 465 LEU B 1348 REMARK 465 GLU B 1349 REMARK 465 ASP B 1350 REMARK 465 SER B 1351 REMARK 465 LYS B 1352 REMARK 465 ARG B 1353 REMARK 465 SER B 1354 REMARK 465 LYS B 1355 REMARK 465 SER B 1356 REMARK 465 LEU B 1357 REMARK 465 LEU B 1358 REMARK 465 PRO B 1359 REMARK 465 ASP B 1360 REMARK 465 HIS B 1361 REMARK 465 ALA B 1362 REMARK 465 SER B 1363 REMARK 465 ASP B 1364 REMARK 465 ASN B 1365 REMARK 465 PRO B 1366 REMARK 465 PHE B 1367 REMARK 465 LEU B 1368 REMARK 465 HIS B 1369 REMARK 465 THR B 1370 REMARK 465 TYR B 1371 REMARK 465 GLY B 1372 REMARK 465 ASP B 1373 REMARK 465 ASP B 1374 REMARK 465 GLN B 1375 REMARK 465 ARG B 1376 REMARK 465 LEU B 1377 REMARK 465 VAL B 1378 REMARK 465 ILE B 1379 REMARK 465 GLY B 1380 REMARK 465 ARG B 1381 REMARK 465 CYS B 1382 REMARK 465 PRO B 1383 REMARK 465 SER B 1384 REMARK 465 ASP B 1385 REMARK 465 PRO B 1386 REMARK 465 TYR B 1387 REMARK 465 LYS B 1388 REMARK 465 HIS B 1389 REMARK 465 SER B 1390 REMARK 465 LEU B 1391 REMARK 465 PRO B 1392 REMARK 465 SER B 1393 REMARK 465 GLN B 1394 REMARK 465 ALA B 1395 REMARK 465 VAL B 1396 REMARK 465 ASN B 1397 REMARK 465 ASP B 1398 REMARK 465 SER B 1399 REMARK 465 TYR B 1400 REMARK 465 LEU B 1401 REMARK 465 ARG B 1402 REMARK 465 SER B 1403 REMARK 465 SER B 1404 REMARK 465 LEU B 1405 REMARK 465 ARG B 1406 REMARK 465 SER B 1407 REMARK 465 THR B 1408 REMARK 465 ALA B 1409 REMARK 465 SER B 1410 REMARK 465 TYR B 1411 REMARK 465 CYS B 1412 REMARK 465 SER B 1413 REMARK 465 ARG B 1414 REMARK 465 ASP B 1415 REMARK 465 SER B 1416 REMARK 465 ARG B 1417 REMARK 465 GLY B 1418 REMARK 465 HIS B 1419 REMARK 465 SER B 1420 REMARK 465 ASP B 1421 REMARK 465 VAL B 1422 REMARK 465 TYR B 1423 REMARK 465 ILE B 1424 REMARK 465 SER B 1425 REMARK 465 GLU B 1426 REMARK 465 HIS B 1427 REMARK 465 VAL B 1428 REMARK 465 MET B 1429 REMARK 465 PRO B 1430 REMARK 465 TYR B 1431 REMARK 465 ALA B 1432 REMARK 465 ALA B 1433 REMARK 465 ASN B 1434 REMARK 465 LYS B 1435 REMARK 465 ASN B 1436 REMARK 465 THR B 1437 REMARK 465 MET B 1438 REMARK 465 TYR B 1439 REMARK 465 SER B 1440 REMARK 465 THR B 1441 REMARK 465 PRO B 1442 REMARK 465 ARG B 1443 REMARK 465 VAL B 1444 REMARK 465 LEU B 1445 REMARK 465 ASN B 1446 REMARK 465 SER B 1447 REMARK 465 CYS B 1448 REMARK 465 SER B 1449 REMARK 465 ASN B 1450 REMARK 465 ARG B 1451 REMARK 465 ARG B 1452 REMARK 465 VAL B 1453 REMARK 465 TYR B 1454 REMARK 465 LYS B 1455 REMARK 465 LYS B 1456 REMARK 465 MET B 1457 REMARK 465 PRO B 1458 REMARK 465 SER B 1459 REMARK 465 ILE B 1460 REMARK 465 GLU B 1461 REMARK 465 SER B 1462 REMARK 465 ASP B 1463 REMARK 465 VAL B 1464 REMARK 465 MET C 1 REMARK 465 SER C 2 REMARK 465 THR C 3 REMARK 465 MET C 4 REMARK 465 HIS C 5 REMARK 465 LEU C 6 REMARK 465 LEU C 7 REMARK 465 THR C 8 REMARK 465 PHE C 9 REMARK 465 ALA C 10 REMARK 465 LEU C 11 REMARK 465 LEU C 12 REMARK 465 PHE C 13 REMARK 465 SER C 14 REMARK 465 CYS C 15 REMARK 465 SER C 16 REMARK 465 PHE C 17 REMARK 465 ALA C 18 REMARK 465 ARG C 19 REMARK 465 ALA C 20 REMARK 465 ALA C 21 REMARK 465 CYS C 22 REMARK 465 ASP C 23 REMARK 465 PRO C 24 REMARK 465 PRO C 585 REMARK 465 PHE C 586 REMARK 465 GLY C 587 REMARK 465 ARG C 588 REMARK 465 PHE C 589 REMARK 465 LYS C 590 REMARK 465 VAL C 591 REMARK 465 ASN C 592 REMARK 465 SER C 593 REMARK 465 GLU C 594 REMARK 465 GLU C 595 REMARK 465 GLU C 596 REMARK 465 GLU C 597 REMARK 465 GLU C 598 REMARK 465 ASP C 599 REMARK 465 ALA C 600 REMARK 465 LEU C 601 REMARK 465 ASP C 842 REMARK 465 ALA C 843 REMARK 465 ARG C 844 REMARK 465 ARG C 845 REMARK 465 LYS C 846 REMARK 465 GLN C 847 REMARK 465 MET C 848 REMARK 465 GLN C 849 REMARK 465 LEU C 850 REMARK 465 ALA C 851 REMARK 465 PHE C 852 REMARK 465 ALA C 853 REMARK 465 ALA C 854 REMARK 465 VAL C 855 REMARK 465 ASN C 856 REMARK 465 VAL C 857 REMARK 465 TRP C 858 REMARK 465 ARG C 859 REMARK 465 LYS C 860 REMARK 465 ASN C 861 REMARK 465 LEU C 862 REMARK 465 GLN C 863 REMARK 465 ASP C 864 REMARK 465 ARG C 865 REMARK 465 LYS C 866 REMARK 465 SER C 867 REMARK 465 GLY C 868 REMARK 465 ARG C 869 REMARK 465 ALA C 870 REMARK 465 GLU C 871 REMARK 465 PRO C 872 REMARK 465 ASP C 873 REMARK 465 PRO C 874 REMARK 465 LYS C 875 REMARK 465 LYS C 876 REMARK 465 LYS C 877 REMARK 465 ALA C 878 REMARK 465 THR C 879 REMARK 465 PHE C 880 REMARK 465 ARG C 881 REMARK 465 ALA C 882 REMARK 465 ILE C 883 REMARK 465 THR C 884 REMARK 465 SER C 885 REMARK 465 THR C 886 REMARK 465 LEU C 887 REMARK 465 ALA C 888 REMARK 465 SER C 889 REMARK 465 SER C 890 REMARK 465 PHE C 891 REMARK 465 LYS C 892 REMARK 465 ARG C 893 REMARK 465 ARG C 894 REMARK 465 ARG C 895 REMARK 465 SER C 896 REMARK 465 SER C 897 REMARK 465 LYS C 898 REMARK 465 ASP C 899 REMARK 465 THR C 900 REMARK 465 SER C 901 REMARK 465 THR C 902 REMARK 465 GLY C 903 REMARK 465 GLY C 904 REMARK 465 GLY C 905 REMARK 465 ARG C 906 REMARK 465 GLY C 907 REMARK 465 ALA C 908 REMARK 465 LEU C 909 REMARK 465 GLN C 910 REMARK 465 ASN C 911 REMARK 465 GLN C 912 REMARK 465 LYS C 913 REMARK 465 ASP C 914 REMARK 465 THR C 915 REMARK 465 VAL C 916 REMARK 465 LEU C 917 REMARK 465 PRO C 918 REMARK 465 ARG C 919 REMARK 465 ARG C 920 REMARK 465 ALA C 921 REMARK 465 ILE C 922 REMARK 465 GLU C 923 REMARK 465 ARG C 924 REMARK 465 GLU C 925 REMARK 465 GLU C 926 REMARK 465 GLY C 927 REMARK 465 GLN C 928 REMARK 465 LEU C 929 REMARK 465 GLN C 930 REMARK 465 LEU C 931 REMARK 465 CYS C 932 REMARK 465 SER C 933 REMARK 465 ARG C 934 REMARK 465 HIS C 935 REMARK 465 ARG C 936 REMARK 465 GLU C 937 REMARK 465 SER C 938 REMARK 465 MET D 1 REMARK 465 LYS D 2 REMARK 465 PRO D 3 REMARK 465 SER D 4 REMARK 465 ALA D 5 REMARK 465 GLU D 6 REMARK 465 CYS D 7 REMARK 465 CYS D 8 REMARK 465 SER D 9 REMARK 465 PRO D 10 REMARK 465 LYS D 11 REMARK 465 PHE D 12 REMARK 465 TRP D 13 REMARK 465 LEU D 14 REMARK 465 VAL D 15 REMARK 465 LEU D 16 REMARK 465 ALA D 17 REMARK 465 VAL D 18 REMARK 465 LEU D 19 REMARK 465 ALA D 20 REMARK 465 VAL D 21 REMARK 465 SER D 22 REMARK 465 GLY D 23 REMARK 465 SER D 24 REMARK 465 LYS D 25 REMARK 465 ALA D 26 REMARK 465 ARG D 27 REMARK 465 SER D 28 REMARK 465 GLN D 29 REMARK 465 LYS D 30 REMARK 465 SER D 31 REMARK 465 PRO D 32 REMARK 465 PRO D 33 REMARK 465 SER D 34 REMARK 465 SER D 581 REMARK 465 PRO D 582 REMARK 465 VAL D 583 REMARK 465 GLY D 584 REMARK 465 TYR D 585 REMARK 465 ASN D 586 REMARK 465 ARG D 587 REMARK 465 CYS D 588 REMARK 465 LEU D 589 REMARK 465 ALA D 590 REMARK 465 ASP D 591 REMARK 465 GLY D 592 REMARK 465 ARG D 593 REMARK 465 GLU D 594 REMARK 465 PRO D 595 REMARK 465 GLY D 596 REMARK 465 GLY D 597 REMARK 465 PRO D 598 REMARK 465 SER D 599 REMARK 465 PHE D 846 REMARK 465 ARG D 847 REMARK 465 HIS D 848 REMARK 465 CYS D 849 REMARK 465 PHE D 850 REMARK 465 MET D 851 REMARK 465 GLY D 852 REMARK 465 VAL D 853 REMARK 465 CYS D 854 REMARK 465 SER D 855 REMARK 465 GLY D 856 REMARK 465 LYS D 857 REMARK 465 PRO D 858 REMARK 465 GLY D 859 REMARK 465 MET D 860 REMARK 465 VAL D 861 REMARK 465 PHE D 862 REMARK 465 SER D 863 REMARK 465 ILE D 864 REMARK 465 SER D 865 REMARK 465 ARG D 866 REMARK 465 GLY D 867 REMARK 465 ILE D 868 REMARK 465 TYR D 869 REMARK 465 SER D 870 REMARK 465 CYS D 871 REMARK 465 ILE D 872 REMARK 465 HIS D 873 REMARK 465 GLY D 874 REMARK 465 VAL D 875 REMARK 465 ALA D 876 REMARK 465 ILE D 877 REMARK 465 GLU D 878 REMARK 465 GLU D 879 REMARK 465 ARG D 880 REMARK 465 GLN D 881 REMARK 465 SER D 882 REMARK 465 VAL D 883 REMARK 465 MET D 884 REMARK 465 ASN D 885 REMARK 465 SER D 886 REMARK 465 PRO D 887 REMARK 465 THR D 888 REMARK 465 ALA D 889 REMARK 465 THR D 890 REMARK 465 MET D 891 REMARK 465 ASN D 892 REMARK 465 ASN D 893 REMARK 465 THR D 894 REMARK 465 HIS D 895 REMARK 465 SER D 896 REMARK 465 ASN D 897 REMARK 465 ILE D 898 REMARK 465 LEU D 899 REMARK 465 ARG D 900 REMARK 465 LEU D 901 REMARK 465 LEU D 902 REMARK 465 ARG D 903 REMARK 465 THR D 904 REMARK 465 ALA D 905 REMARK 465 LYS D 906 REMARK 465 ASN D 907 REMARK 465 MET D 908 REMARK 465 ALA D 909 REMARK 465 ASN D 910 REMARK 465 LEU D 911 REMARK 465 SER D 912 REMARK 465 GLY D 913 REMARK 465 VAL D 914 REMARK 465 ASN D 915 REMARK 465 GLY D 916 REMARK 465 SER D 917 REMARK 465 PRO D 918 REMARK 465 GLN D 919 REMARK 465 SER D 920 REMARK 465 ALA D 921 REMARK 465 LEU D 922 REMARK 465 ASP D 923 REMARK 465 PHE D 924 REMARK 465 ILE D 925 REMARK 465 ARG D 926 REMARK 465 ARG D 927 REMARK 465 GLU D 928 REMARK 465 SER D 929 REMARK 465 SER D 930 REMARK 465 VAL D 931 REMARK 465 TYR D 932 REMARK 465 ASP D 933 REMARK 465 ILE D 934 REMARK 465 SER D 935 REMARK 465 GLU D 936 REMARK 465 HIS D 937 REMARK 465 ARG D 938 REMARK 465 ARG D 939 REMARK 465 SER D 940 REMARK 465 PHE D 941 REMARK 465 THR D 942 REMARK 465 HIS D 943 REMARK 465 SER D 944 REMARK 465 ASP D 945 REMARK 465 CYS D 946 REMARK 465 LYS D 947 REMARK 465 SER D 948 REMARK 465 TYR D 949 REMARK 465 ASN D 950 REMARK 465 ASN D 951 REMARK 465 PRO D 952 REMARK 465 PRO D 953 REMARK 465 CYS D 954 REMARK 465 GLU D 955 REMARK 465 GLU D 956 REMARK 465 ASN D 957 REMARK 465 LEU D 958 REMARK 465 PHE D 959 REMARK 465 SER D 960 REMARK 465 ASP D 961 REMARK 465 TYR D 962 REMARK 465 ILE D 963 REMARK 465 SER D 964 REMARK 465 GLU D 965 REMARK 465 VAL D 966 REMARK 465 GLU D 967 REMARK 465 ARG D 968 REMARK 465 THR D 969 REMARK 465 PHE D 970 REMARK 465 GLY D 971 REMARK 465 ASN D 972 REMARK 465 LEU D 973 REMARK 465 GLN D 974 REMARK 465 LEU D 975 REMARK 465 LYS D 976 REMARK 465 ASP D 977 REMARK 465 SER D 978 REMARK 465 ASN D 979 REMARK 465 VAL D 980 REMARK 465 TYR D 981 REMARK 465 GLN D 982 REMARK 465 ASP D 983 REMARK 465 HIS D 984 REMARK 465 TYR D 985 REMARK 465 HIS D 986 REMARK 465 HIS D 987 REMARK 465 HIS D 988 REMARK 465 HIS D 989 REMARK 465 ARG D 990 REMARK 465 PRO D 991 REMARK 465 HIS D 992 REMARK 465 SER D 993 REMARK 465 ILE D 994 REMARK 465 GLY D 995 REMARK 465 SER D 996 REMARK 465 THR D 997 REMARK 465 SER D 998 REMARK 465 SER D 999 REMARK 465 ILE D 1000 REMARK 465 ASP D 1001 REMARK 465 GLY D 1002 REMARK 465 LEU D 1003 REMARK 465 TYR D 1004 REMARK 465 ASP D 1005 REMARK 465 CYS D 1006 REMARK 465 ASP D 1007 REMARK 465 ASN D 1008 REMARK 465 PRO D 1009 REMARK 465 PRO D 1010 REMARK 465 PHE D 1011 REMARK 465 THR D 1012 REMARK 465 THR D 1013 REMARK 465 GLN D 1014 REMARK 465 PRO D 1015 REMARK 465 ARG D 1016 REMARK 465 SER D 1017 REMARK 465 ILE D 1018 REMARK 465 SER D 1019 REMARK 465 LYS D 1020 REMARK 465 LYS D 1021 REMARK 465 PRO D 1022 REMARK 465 LEU D 1023 REMARK 465 ASP D 1024 REMARK 465 ILE D 1025 REMARK 465 GLY D 1026 REMARK 465 LEU D 1027 REMARK 465 PRO D 1028 REMARK 465 SER D 1029 REMARK 465 SER D 1030 REMARK 465 LYS D 1031 REMARK 465 HIS D 1032 REMARK 465 SER D 1033 REMARK 465 GLN D 1034 REMARK 465 LEU D 1035 REMARK 465 SER D 1036 REMARK 465 ASP D 1037 REMARK 465 LEU D 1038 REMARK 465 TYR D 1039 REMARK 465 GLY D 1040 REMARK 465 LYS D 1041 REMARK 465 PHE D 1042 REMARK 465 SER D 1043 REMARK 465 PHE D 1044 REMARK 465 LYS D 1045 REMARK 465 SER D 1046 REMARK 465 ASP D 1047 REMARK 465 ARG D 1048 REMARK 465 TYR D 1049 REMARK 465 SER D 1050 REMARK 465 GLY D 1051 REMARK 465 HIS D 1052 REMARK 465 ASP D 1053 REMARK 465 ASP D 1054 REMARK 465 LEU D 1055 REMARK 465 ILE D 1056 REMARK 465 ARG D 1057 REMARK 465 SER D 1058 REMARK 465 ASP D 1059 REMARK 465 VAL D 1060 REMARK 465 SER D 1061 REMARK 465 ASP D 1062 REMARK 465 ILE D 1063 REMARK 465 SER D 1064 REMARK 465 THR D 1065 REMARK 465 HIS D 1066 REMARK 465 THR D 1067 REMARK 465 VAL D 1068 REMARK 465 THR D 1069 REMARK 465 TYR D 1070 REMARK 465 GLY D 1071 REMARK 465 ASN D 1072 REMARK 465 ILE D 1073 REMARK 465 GLU D 1074 REMARK 465 GLY D 1075 REMARK 465 ASN D 1076 REMARK 465 ALA D 1077 REMARK 465 ALA D 1078 REMARK 465 LYS D 1079 REMARK 465 ARG D 1080 REMARK 465 ARG D 1081 REMARK 465 LYS D 1082 REMARK 465 GLN D 1083 REMARK 465 GLN D 1084 REMARK 465 TYR D 1085 REMARK 465 LYS D 1086 REMARK 465 ASP D 1087 REMARK 465 SER D 1088 REMARK 465 LEU D 1089 REMARK 465 LYS D 1090 REMARK 465 LYS D 1091 REMARK 465 ARG D 1092 REMARK 465 PRO D 1093 REMARK 465 ALA D 1094 REMARK 465 SER D 1095 REMARK 465 ALA D 1096 REMARK 465 LYS D 1097 REMARK 465 SER D 1098 REMARK 465 ARG D 1099 REMARK 465 ARG D 1100 REMARK 465 GLU D 1101 REMARK 465 PHE D 1102 REMARK 465 ASP D 1103 REMARK 465 GLU D 1104 REMARK 465 ILE D 1105 REMARK 465 GLU D 1106 REMARK 465 LEU D 1107 REMARK 465 ALA D 1108 REMARK 465 TYR D 1109 REMARK 465 ARG D 1110 REMARK 465 ARG D 1111 REMARK 465 ARG D 1112 REMARK 465 PRO D 1113 REMARK 465 PRO D 1114 REMARK 465 ARG D 1115 REMARK 465 SER D 1116 REMARK 465 PRO D 1117 REMARK 465 ASP D 1118 REMARK 465 HIS D 1119 REMARK 465 LYS D 1120 REMARK 465 ARG D 1121 REMARK 465 TYR D 1122 REMARK 465 PHE D 1123 REMARK 465 ARG D 1124 REMARK 465 ASP D 1125 REMARK 465 LYS D 1126 REMARK 465 GLU D 1127 REMARK 465 GLY D 1128 REMARK 465 LEU D 1129 REMARK 465 ARG D 1130 REMARK 465 ASP D 1131 REMARK 465 PHE D 1132 REMARK 465 TYR D 1133 REMARK 465 LEU D 1134 REMARK 465 ASP D 1135 REMARK 465 GLN D 1136 REMARK 465 PHE D 1137 REMARK 465 ARG D 1138 REMARK 465 THR D 1139 REMARK 465 LYS D 1140 REMARK 465 GLU D 1141 REMARK 465 ASN D 1142 REMARK 465 SER D 1143 REMARK 465 PRO D 1144 REMARK 465 HIS D 1145 REMARK 465 TRP D 1146 REMARK 465 GLU D 1147 REMARK 465 HIS D 1148 REMARK 465 VAL D 1149 REMARK 465 ASP D 1150 REMARK 465 LEU D 1151 REMARK 465 THR D 1152 REMARK 465 ASP D 1153 REMARK 465 ILE D 1154 REMARK 465 TYR D 1155 REMARK 465 LYS D 1156 REMARK 465 GLU D 1157 REMARK 465 ARG D 1158 REMARK 465 SER D 1159 REMARK 465 ASP D 1160 REMARK 465 ASP D 1161 REMARK 465 PHE D 1162 REMARK 465 LYS D 1163 REMARK 465 ARG D 1164 REMARK 465 ASP D 1165 REMARK 465 SER D 1166 REMARK 465 VAL D 1167 REMARK 465 SER D 1168 REMARK 465 GLY D 1169 REMARK 465 GLY D 1170 REMARK 465 GLY D 1171 REMARK 465 PRO D 1172 REMARK 465 CYS D 1173 REMARK 465 THR D 1174 REMARK 465 ASN D 1175 REMARK 465 ARG D 1176 REMARK 465 SER D 1177 REMARK 465 HIS D 1178 REMARK 465 LEU D 1179 REMARK 465 LYS D 1180 REMARK 465 HIS D 1181 REMARK 465 GLY D 1182 REMARK 465 THR D 1183 REMARK 465 GLY D 1184 REMARK 465 GLU D 1185 REMARK 465 LYS D 1186 REMARK 465 HIS D 1187 REMARK 465 GLY D 1188 REMARK 465 VAL D 1189 REMARK 465 VAL D 1190 REMARK 465 GLY D 1191 REMARK 465 GLY D 1192 REMARK 465 VAL D 1193 REMARK 465 PRO D 1194 REMARK 465 ALA D 1195 REMARK 465 PRO D 1196 REMARK 465 TRP D 1197 REMARK 465 GLU D 1198 REMARK 465 LYS D 1199 REMARK 465 ASN D 1200 REMARK 465 LEU D 1201 REMARK 465 THR D 1202 REMARK 465 ASN D 1203 REMARK 465 VAL D 1204 REMARK 465 ASP D 1205 REMARK 465 TRP D 1206 REMARK 465 GLU D 1207 REMARK 465 ASP D 1208 REMARK 465 ARG D 1209 REMARK 465 SER D 1210 REMARK 465 GLY D 1211 REMARK 465 GLY D 1212 REMARK 465 ASN D 1213 REMARK 465 PHE D 1214 REMARK 465 CYS D 1215 REMARK 465 ARG D 1216 REMARK 465 SER D 1217 REMARK 465 CYS D 1218 REMARK 465 PRO D 1219 REMARK 465 SER D 1220 REMARK 465 LYS D 1221 REMARK 465 LEU D 1222 REMARK 465 HIS D 1223 REMARK 465 ASN D 1224 REMARK 465 TYR D 1225 REMARK 465 SER D 1226 REMARK 465 SER D 1227 REMARK 465 THR D 1228 REMARK 465 VAL D 1229 REMARK 465 ALA D 1230 REMARK 465 GLY D 1231 REMARK 465 GLN D 1232 REMARK 465 ASN D 1233 REMARK 465 SER D 1234 REMARK 465 GLY D 1235 REMARK 465 ARG D 1236 REMARK 465 GLN D 1237 REMARK 465 ALA D 1238 REMARK 465 CYS D 1239 REMARK 465 ILE D 1240 REMARK 465 ARG D 1241 REMARK 465 CYS D 1242 REMARK 465 GLU D 1243 REMARK 465 ALA D 1244 REMARK 465 CYS D 1245 REMARK 465 LYS D 1246 REMARK 465 LYS D 1247 REMARK 465 ALA D 1248 REMARK 465 GLY D 1249 REMARK 465 ASN D 1250 REMARK 465 LEU D 1251 REMARK 465 TYR D 1252 REMARK 465 ASP D 1253 REMARK 465 ILE D 1254 REMARK 465 SER D 1255 REMARK 465 GLU D 1256 REMARK 465 ASP D 1257 REMARK 465 ASN D 1258 REMARK 465 SER D 1259 REMARK 465 LEU D 1260 REMARK 465 GLN D 1261 REMARK 465 GLU D 1262 REMARK 465 LEU D 1263 REMARK 465 ASP D 1264 REMARK 465 GLN D 1265 REMARK 465 PRO D 1266 REMARK 465 ALA D 1267 REMARK 465 ALA D 1268 REMARK 465 PRO D 1269 REMARK 465 VAL D 1270 REMARK 465 ALA D 1271 REMARK 465 VAL D 1272 REMARK 465 THR D 1273 REMARK 465 SER D 1274 REMARK 465 ASN D 1275 REMARK 465 ALA D 1276 REMARK 465 SER D 1277 REMARK 465 SER D 1278 REMARK 465 THR D 1279 REMARK 465 LYS D 1280 REMARK 465 TYR D 1281 REMARK 465 PRO D 1282 REMARK 465 GLN D 1283 REMARK 465 SER D 1284 REMARK 465 PRO D 1285 REMARK 465 THR D 1286 REMARK 465 ASN D 1287 REMARK 465 SER D 1288 REMARK 465 LYS D 1289 REMARK 465 ALA D 1290 REMARK 465 GLN D 1291 REMARK 465 LYS D 1292 REMARK 465 LYS D 1293 REMARK 465 ASN D 1294 REMARK 465 ARG D 1295 REMARK 465 ASN D 1296 REMARK 465 LYS D 1297 REMARK 465 LEU D 1298 REMARK 465 ARG D 1299 REMARK 465 ARG D 1300 REMARK 465 GLN D 1301 REMARK 465 HIS D 1302 REMARK 465 SER D 1303 REMARK 465 TYR D 1304 REMARK 465 ASP D 1305 REMARK 465 THR D 1306 REMARK 465 PHE D 1307 REMARK 465 VAL D 1308 REMARK 465 ASP D 1309 REMARK 465 LEU D 1310 REMARK 465 GLN D 1311 REMARK 465 LYS D 1312 REMARK 465 GLU D 1313 REMARK 465 GLU D 1314 REMARK 465 ALA D 1315 REMARK 465 ALA D 1316 REMARK 465 LEU D 1317 REMARK 465 ALA D 1318 REMARK 465 PRO D 1319 REMARK 465 ARG D 1320 REMARK 465 SER D 1321 REMARK 465 VAL D 1322 REMARK 465 SER D 1323 REMARK 465 LEU D 1324 REMARK 465 LYS D 1325 REMARK 465 ASP D 1326 REMARK 465 LYS D 1327 REMARK 465 GLY D 1328 REMARK 465 ARG D 1329 REMARK 465 PHE D 1330 REMARK 465 MET D 1331 REMARK 465 ASP D 1332 REMARK 465 GLY D 1333 REMARK 465 SER D 1334 REMARK 465 PRO D 1335 REMARK 465 TYR D 1336 REMARK 465 ALA D 1337 REMARK 465 HIS D 1338 REMARK 465 MET D 1339 REMARK 465 PHE D 1340 REMARK 465 GLU D 1341 REMARK 465 MET D 1342 REMARK 465 PRO D 1343 REMARK 465 ALA D 1344 REMARK 465 GLY D 1345 REMARK 465 GLU D 1346 REMARK 465 SER D 1347 REMARK 465 SER D 1348 REMARK 465 PHE D 1349 REMARK 465 ALA D 1350 REMARK 465 ASN D 1351 REMARK 465 LYS D 1352 REMARK 465 SER D 1353 REMARK 465 SER D 1354 REMARK 465 VAL D 1355 REMARK 465 PRO D 1356 REMARK 465 THR D 1357 REMARK 465 ALA D 1358 REMARK 465 GLY D 1359 REMARK 465 HIS D 1360 REMARK 465 HIS D 1361 REMARK 465 HIS D 1362 REMARK 465 ASN D 1363 REMARK 465 ASN D 1364 REMARK 465 PRO D 1365 REMARK 465 GLY D 1366 REMARK 465 SER D 1367 REMARK 465 GLY D 1368 REMARK 465 TYR D 1369 REMARK 465 MET D 1370 REMARK 465 LEU D 1371 REMARK 465 SER D 1372 REMARK 465 LYS D 1373 REMARK 465 SER D 1374 REMARK 465 LEU D 1375 REMARK 465 TYR D 1376 REMARK 465 PRO D 1377 REMARK 465 ASP D 1378 REMARK 465 ARG D 1379 REMARK 465 VAL D 1380 REMARK 465 THR D 1381 REMARK 465 GLN D 1382 REMARK 465 ASN D 1383 REMARK 465 PRO D 1384 REMARK 465 PHE D 1385 REMARK 465 ILE D 1386 REMARK 465 PRO D 1387 REMARK 465 THR D 1388 REMARK 465 PHE D 1389 REMARK 465 GLY D 1390 REMARK 465 ASP D 1391 REMARK 465 ASP D 1392 REMARK 465 GLN D 1393 REMARK 465 CYS D 1394 REMARK 465 LEU D 1395 REMARK 465 LEU D 1396 REMARK 465 HIS D 1397 REMARK 465 GLY D 1398 REMARK 465 SER D 1399 REMARK 465 LYS D 1400 REMARK 465 SER D 1401 REMARK 465 TYR D 1402 REMARK 465 PHE D 1403 REMARK 465 PHE D 1404 REMARK 465 ARG D 1405 REMARK 465 GLN D 1406 REMARK 465 PRO D 1407 REMARK 465 THR D 1408 REMARK 465 VAL D 1409 REMARK 465 ALA D 1410 REMARK 465 GLY D 1411 REMARK 465 ALA D 1412 REMARK 465 SER D 1413 REMARK 465 LYS D 1414 REMARK 465 THR D 1415 REMARK 465 ARG D 1416 REMARK 465 PRO D 1417 REMARK 465 ASP D 1418 REMARK 465 PHE D 1419 REMARK 465 ARG D 1420 REMARK 465 ALA D 1421 REMARK 465 LEU D 1422 REMARK 465 VAL D 1423 REMARK 465 THR D 1424 REMARK 465 ASN D 1425 REMARK 465 LYS D 1426 REMARK 465 PRO D 1427 REMARK 465 VAL D 1428 REMARK 465 VAL D 1429 REMARK 465 VAL D 1430 REMARK 465 THR D 1431 REMARK 465 LEU D 1432 REMARK 465 HIS D 1433 REMARK 465 GLY D 1434 REMARK 465 ALA D 1435 REMARK 465 VAL D 1436 REMARK 465 PRO D 1437 REMARK 465 GLY D 1438 REMARK 465 ARG D 1439 REMARK 465 PHE D 1440 REMARK 465 GLN D 1441 REMARK 465 LYS D 1442 REMARK 465 ASP D 1443 REMARK 465 ILE D 1444 REMARK 465 CYS D 1445 REMARK 465 ILE D 1446 REMARK 465 GLY D 1447 REMARK 465 ASN D 1448 REMARK 465 GLN D 1449 REMARK 465 SER D 1450 REMARK 465 ASN D 1451 REMARK 465 PRO D 1452 REMARK 465 CYS D 1453 REMARK 465 VAL D 1454 REMARK 465 PRO D 1455 REMARK 465 ASN D 1456 REMARK 465 ASN D 1457 REMARK 465 LYS D 1458 REMARK 465 ASN D 1459 REMARK 465 PRO D 1460 REMARK 465 ARG D 1461 REMARK 465 ALA D 1462 REMARK 465 PHE D 1463 REMARK 465 ASN D 1464 REMARK 465 GLY D 1465 REMARK 465 SER D 1466 REMARK 465 SER D 1467 REMARK 465 ASN D 1468 REMARK 465 GLY D 1469 REMARK 465 HIS D 1470 REMARK 465 VAL D 1471 REMARK 465 TYR D 1472 REMARK 465 GLU D 1473 REMARK 465 LYS D 1474 REMARK 465 LEU D 1475 REMARK 465 SER D 1476 REMARK 465 SER D 1477 REMARK 465 ILE D 1478 REMARK 465 GLU D 1479 REMARK 465 SER D 1480 REMARK 465 ASP D 1481 REMARK 465 VAL D 1482 REMARK 465 PRO E -1 REMARK 465 MET E 0 REMARK 465 VAL E 1 REMARK 465 SER E 2 REMARK 465 ALA E 3 REMARK 465 ILE E 4 REMARK 465 VAL E 5 REMARK 465 LEU E 6 REMARK 465 TYR E 7 REMARK 465 VAL E 8 REMARK 465 LEU E 9 REMARK 465 LEU E 10 REMARK 465 ALA E 11 REMARK 465 ALA E 12 REMARK 465 ALA E 13 REMARK 465 ALA E 14 REMARK 465 HIS E 15 REMARK 465 SER E 16 REMARK 465 ALA E 17 REMARK 465 PHE E 18 REMARK 465 ALA E 19 REMARK 465 MET E 20 REMARK 465 MET F 0 REMARK 465 VAL F 1 REMARK 465 SER F 2 REMARK 465 ALA F 3 REMARK 465 ILE F 4 REMARK 465 VAL F 5 REMARK 465 LEU F 6 REMARK 465 TYR F 7 REMARK 465 VAL F 8 REMARK 465 LEU F 9 REMARK 465 LEU F 10 REMARK 465 ALA F 11 REMARK 465 ALA F 12 REMARK 465 ALA F 13 REMARK 465 ALA F 14 REMARK 465 HIS F 15 REMARK 465 SER F 16 REMARK 465 ALA F 17 REMARK 465 PHE F 18 REMARK 465 ALA F 19 REMARK 465 MET F 20 REMARK 465 PRO I -1 REMARK 465 MET I 0 REMARK 465 VAL I 1 REMARK 465 SER I 2 REMARK 465 ALA I 3 REMARK 465 ILE I 4 REMARK 465 VAL I 5 REMARK 465 LEU I 6 REMARK 465 TYR I 7 REMARK 465 VAL I 8 REMARK 465 LEU I 9 REMARK 465 LEU I 10 REMARK 465 ALA I 11 REMARK 465 ALA I 12 REMARK 465 ALA I 13 REMARK 465 ALA I 14 REMARK 465 HIS I 15 REMARK 465 SER I 16 REMARK 465 ALA I 17 REMARK 465 PHE I 18 REMARK 465 ALA I 19 REMARK 465 MET I 20 REMARK 465 MET J 0 REMARK 465 VAL J 1 REMARK 465 SER J 2 REMARK 465 ALA J 3 REMARK 465 ILE J 4 REMARK 465 VAL J 5 REMARK 465 LEU J 6 REMARK 465 TYR J 7 REMARK 465 VAL J 8 REMARK 465 LEU J 9 REMARK 465 LEU J 10 REMARK 465 ALA J 11 REMARK 465 ALA J 12 REMARK 465 ALA J 13 REMARK 465 ALA J 14 REMARK 465 HIS J 15 REMARK 465 SER J 16 REMARK 465 ALA J 17 REMARK 465 PHE J 18 REMARK 465 ALA J 19 REMARK 465 MET J 20 REMARK 465 MET K 1 REMARK 465 VAL K 2 REMARK 465 SER K 3 REMARK 465 ALA K 4 REMARK 465 ILE K 5 REMARK 465 VAL K 6 REMARK 465 LEU K 7 REMARK 465 TYR K 8 REMARK 465 VAL K 9 REMARK 465 LEU K 10 REMARK 465 LEU K 11 REMARK 465 ALA K 12 REMARK 465 ALA K 13 REMARK 465 ALA K 14 REMARK 465 ALA K 15 REMARK 465 HIS K 16 REMARK 465 SER K 17 REMARK 465 ALA K 18 REMARK 465 PHE K 19 REMARK 465 ALA K 20 REMARK 465 ASP K 21 REMARK 465 GLY K 46 REMARK 465 PHE K 47 REMARK 465 SER K 141 REMARK 465 SER K 142 REMARK 465 ALA K 143 REMARK 465 LYS K 144 REMARK 465 THR K 145 REMARK 465 LYS K 146 REMARK 465 GLY K 147 REMARK 465 PRO K 148 REMARK 465 SER K 149 REMARK 465 VAL K 150 REMARK 465 PHE K 151 REMARK 465 PRO K 152 REMARK 465 LEU K 153 REMARK 465 ALA K 154 REMARK 465 PRO K 155 REMARK 465 SER K 156 REMARK 465 SER K 157 REMARK 465 LYS K 158 REMARK 465 SER K 159 REMARK 465 THR K 160 REMARK 465 SER K 161 REMARK 465 GLY K 162 REMARK 465 GLY K 163 REMARK 465 THR K 164 REMARK 465 ALA K 165 REMARK 465 ALA K 166 REMARK 465 LEU K 167 REMARK 465 GLY K 168 REMARK 465 CYS K 169 REMARK 465 LEU K 170 REMARK 465 VAL K 171 REMARK 465 LYS K 172 REMARK 465 ASP K 173 REMARK 465 TYR K 174 REMARK 465 PHE K 175 REMARK 465 PRO K 176 REMARK 465 GLU K 177 REMARK 465 PRO K 178 REMARK 465 VAL K 179 REMARK 465 THR K 180 REMARK 465 VAL K 181 REMARK 465 SER K 182 REMARK 465 TRP K 183 REMARK 465 ASN K 184 REMARK 465 SER K 185 REMARK 465 GLY K 186 REMARK 465 ALA K 187 REMARK 465 LEU K 188 REMARK 465 THR K 189 REMARK 465 SER K 190 REMARK 465 GLY K 191 REMARK 465 VAL K 192 REMARK 465 HIS K 193 REMARK 465 THR K 194 REMARK 465 PHE K 195 REMARK 465 PRO K 196 REMARK 465 ALA K 197 REMARK 465 VAL K 198 REMARK 465 LEU K 199 REMARK 465 GLN K 200 REMARK 465 SER K 201 REMARK 465 SER K 202 REMARK 465 GLY K 203 REMARK 465 LEU K 204 REMARK 465 TYR K 205 REMARK 465 SER K 206 REMARK 465 LEU K 207 REMARK 465 SER K 208 REMARK 465 SER K 209 REMARK 465 VAL K 210 REMARK 465 VAL K 211 REMARK 465 THR K 212 REMARK 465 VAL K 213 REMARK 465 PRO K 214 REMARK 465 SER K 215 REMARK 465 SER K 216 REMARK 465 SER K 217 REMARK 465 LEU K 218 REMARK 465 GLY K 219 REMARK 465 THR K 220 REMARK 465 GLN K 221 REMARK 465 THR K 222 REMARK 465 TYR K 223 REMARK 465 ILE K 224 REMARK 465 CYS K 225 REMARK 465 ASN K 226 REMARK 465 VAL K 227 REMARK 465 ASN K 228 REMARK 465 HIS K 229 REMARK 465 LYS K 230 REMARK 465 PRO K 231 REMARK 465 SER K 232 REMARK 465 ASN K 233 REMARK 465 THR K 234 REMARK 465 LYS K 235 REMARK 465 VAL K 236 REMARK 465 ASP K 237 REMARK 465 LYS K 238 REMARK 465 ARG K 239 REMARK 465 HIS K 240 REMARK 465 HIS K 241 REMARK 465 HIS K 242 REMARK 465 HIS K 243 REMARK 465 HIS K 244 REMARK 465 HIS K 245 REMARK 465 HIS K 246 REMARK 465 HIS K 247 REMARK 465 HIS K 248 REMARK 465 HIS K 249 REMARK 465 MET L 1 REMARK 465 VAL L 2 REMARK 465 SER L 3 REMARK 465 ALA L 4 REMARK 465 ILE L 5 REMARK 465 VAL L 6 REMARK 465 LEU L 7 REMARK 465 TYR L 8 REMARK 465 VAL L 9 REMARK 465 LEU L 10 REMARK 465 LEU L 11 REMARK 465 ALA L 12 REMARK 465 ALA L 13 REMARK 465 ALA L 14 REMARK 465 ALA L 15 REMARK 465 HIS L 16 REMARK 465 SER L 17 REMARK 465 ALA L 18 REMARK 465 PHE L 19 REMARK 465 ALA L 20 REMARK 465 ARG L 127 REMARK 465 THR L 128 REMARK 465 VAL L 129 REMARK 465 ALA L 130 REMARK 465 ALA L 131 REMARK 465 PRO L 132 REMARK 465 SER L 133 REMARK 465 VAL L 134 REMARK 465 PHE L 135 REMARK 465 ILE L 136 REMARK 465 PHE L 137 REMARK 465 PRO L 138 REMARK 465 PRO L 139 REMARK 465 SER L 140 REMARK 465 ASP L 141 REMARK 465 GLU L 142 REMARK 465 GLN L 143 REMARK 465 LEU L 144 REMARK 465 LYS L 145 REMARK 465 SER L 146 REMARK 465 GLY L 147 REMARK 465 THR L 148 REMARK 465 ALA L 149 REMARK 465 SER L 150 REMARK 465 VAL L 151 REMARK 465 VAL L 152 REMARK 465 CYS L 153 REMARK 465 LEU L 154 REMARK 465 LEU L 155 REMARK 465 ASN L 156 REMARK 465 ASN L 157 REMARK 465 PHE L 158 REMARK 465 TYR L 159 REMARK 465 PRO L 160 REMARK 465 ARG L 161 REMARK 465 GLU L 162 REMARK 465 ALA L 163 REMARK 465 LYS L 164 REMARK 465 VAL L 165 REMARK 465 GLN L 166 REMARK 465 TRP L 167 REMARK 465 LYS L 168 REMARK 465 VAL L 169 REMARK 465 ASP L 170 REMARK 465 ASN L 171 REMARK 465 ALA L 172 REMARK 465 LEU L 173 REMARK 465 GLN L 174 REMARK 465 SER L 175 REMARK 465 GLY L 176 REMARK 465 ASN L 177 REMARK 465 SER L 178 REMARK 465 GLN L 179 REMARK 465 GLU L 180 REMARK 465 SER L 181 REMARK 465 VAL L 182 REMARK 465 THR L 183 REMARK 465 GLU L 184 REMARK 465 GLN L 185 REMARK 465 ASP L 186 REMARK 465 SER L 187 REMARK 465 LYS L 188 REMARK 465 ASP L 189 REMARK 465 SER L 190 REMARK 465 THR L 191 REMARK 465 TYR L 192 REMARK 465 SER L 193 REMARK 465 LEU L 194 REMARK 465 SER L 195 REMARK 465 SER L 196 REMARK 465 THR L 197 REMARK 465 LEU L 198 REMARK 465 THR L 199 REMARK 465 LEU L 200 REMARK 465 SER L 201 REMARK 465 LYS L 202 REMARK 465 ALA L 203 REMARK 465 ASP L 204 REMARK 465 TYR L 205 REMARK 465 GLU L 206 REMARK 465 LYS L 207 REMARK 465 HIS L 208 REMARK 465 LYS L 209 REMARK 465 VAL L 210 REMARK 465 TYR L 211 REMARK 465 ALA L 212 REMARK 465 CYS L 213 REMARK 465 GLU L 214 REMARK 465 VAL L 215 REMARK 465 THR L 216 REMARK 465 HIS L 217 REMARK 465 GLN L 218 REMARK 465 GLY L 219 REMARK 465 LEU L 220 REMARK 465 SER L 221 REMARK 465 SER L 222 REMARK 465 PRO L 223 REMARK 465 VAL L 224 REMARK 465 THR L 225 REMARK 465 LYS L 226 REMARK 465 SER L 227 REMARK 465 PHE L 228 REMARK 465 ASN L 229 REMARK 465 ARG L 230 REMARK 465 GLY L 231 REMARK 465 GLU L 232 REMARK 465 CYS L 233 REMARK 465 GLY L 234 REMARK 465 SER L 235 REMARK 465 GLY L 236 REMARK 465 SER L 237 REMARK 465 TRP L 238 REMARK 465 SER L 239 REMARK 465 HIS L 240 REMARK 465 PRO L 241 REMARK 465 GLN L 242 REMARK 465 PHE L 243 REMARK 465 GLU L 244 REMARK 465 LYS L 245 REMARK 465 GLY L 246 REMARK 465 GLY L 247 REMARK 465 GLY L 248 REMARK 465 SER L 249 REMARK 465 GLY L 250 REMARK 465 GLY L 251 REMARK 465 GLY L 252 REMARK 465 SER L 253 REMARK 465 GLY L 254 REMARK 465 GLY L 255 REMARK 465 SER L 256 REMARK 465 ALA L 257 REMARK 465 TRP L 258 REMARK 465 SER L 259 REMARK 465 HIS L 260 REMARK 465 PRO L 261 REMARK 465 GLN L 262 REMARK 465 PHE L 263 REMARK 465 GLU L 264 REMARK 465 LYS L 265 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 MET A 818 CG SD CE REMARK 470 ASP D 57 CG OD1 OD2 REMARK 470 SER D 63 OG REMARK 470 GLU D 839 CG CD OE1 OE2 REMARK 470 PHE J 121 CG CD1 CD2 CE1 CE2 CZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 CA GLY A 336 O6 NAG A 1006 1.37 REMARK 500 OH TYR D 762 C05 7RC D 1504 1.93 REMARK 500 O PHE K 129 OH TYR L 56 2.07 REMARK 500 OH TYR L 70 OH TYR L 111 2.09 REMARK 500 N GLY A 336 O6 NAG A 1006 2.13 REMARK 500 O MET B 135 OH TYR B 355 2.13 REMARK 500 OG1 THR L 105 O THR L 121 2.14 REMARK 500 NH2 ARG D 519 O05 7RC D 1504 2.17 REMARK 500 O ASP C 198 OG1 THR C 201 2.17 REMARK 500 CG HIS B 485 O05 7RC B 1504 2.18 REMARK 500 O ILE D 190 OG SER D 193 2.18 REMARK 500 OD2 ASP B 139 OG1 THR B 141 2.18 REMARK 500 O VAL G 149 N PHE G 225 2.18 REMARK 500 OD2 ASP B 731 C03 7RC B 1504 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 ASP E 52 CA ASP E 52 CB -0.193 REMARK 500 ASP E 52 CB ASP E 52 CG -0.155 REMARK 500 ASP E 52 CA ASP E 52 C -0.157 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 ASP E 52 CB - CA - C ANGL. DEV. = -15.0 DEGREES REMARK 500 ASP E 52 N - CA - CB ANGL. DEV. = -24.5 DEGREES REMARK 500 ASP E 52 CA - C - O ANGL. DEV. = -16.3 DEGREES REMARK 500 ALA J 107 O - C - N ANGL. DEV. = -10.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PRO A 98 45.09 -81.34 REMARK 500 ILE A 133 -62.30 -109.97 REMARK 500 ASN A 159 26.78 46.28 REMARK 500 ASN A 161 -53.29 -121.71 REMARK 500 ASP A 169 54.29 -90.38 REMARK 500 ASN A 276 93.52 -69.80 REMARK 500 MET A 415 -165.51 -79.90 REMARK 500 THR A 419 -168.84 -100.93 REMARK 500 ASP A 441 37.67 -99.44 REMARK 500 PRO A 516 71.24 -68.43 REMARK 500 PHE A 583 58.09 -100.49 REMARK 500 TRP A 731 -179.42 -170.55 REMARK 500 CYS A 744 -3.46 68.93 REMARK 500 GLU A 797 -103.09 55.44 REMARK 500 ALA A 806 67.87 64.28 REMARK 500 GLU A 811 -55.78 173.97 REMARK 500 ILE B 127 -65.18 -122.07 REMARK 500 THR B 249 33.76 -94.27 REMARK 500 SER B 311 -5.04 68.53 REMARK 500 ASN B 380 59.37 30.81 REMARK 500 PHE B 396 -136.08 56.69 REMARK 500 LYS B 472 61.00 61.97 REMARK 500 PHE B 613 -70.63 -86.10 REMARK 500 ASN B 614 -173.34 -175.69 REMARK 500 VAL B 659 -34.23 47.85 REMARK 500 ASN B 687 -3.06 73.37 REMARK 500 TYR B 730 -174.67 -171.02 REMARK 500 THR B 759 -168.93 -124.48 REMARK 500 LEU B 796 -158.32 -91.68 REMARK 500 THR B 797 37.47 -90.02 REMARK 500 CYS B 800 -120.56 66.15 REMARK 500 GLU B 806 119.88 -162.24 REMARK 500 PRO C 98 45.26 -77.17 REMARK 500 ARG C 124 14.24 -141.59 REMARK 500 ILE C 133 -63.73 -101.25 REMARK 500 GLU C 188 -5.10 70.50 REMARK 500 ASN C 257 25.89 -141.73 REMARK 500 ASN C 273 48.16 35.86 REMARK 500 PRO C 516 73.45 -69.35 REMARK 500 LYS C 534 119.56 -162.57 REMARK 500 GLU C 545 123.75 48.57 REMARK 500 LEU C 551 111.82 -160.78 REMARK 500 SER C 553 -168.11 -168.33 REMARK 500 LEU C 657 30.77 -97.91 REMARK 500 ARG C 663 39.36 -98.74 REMARK 500 ILE C 664 106.11 69.16 REMARK 500 TRP C 792 -0.75 -140.04 REMARK 500 ARG C 794 38.05 -99.93 REMARK 500 PRO C 805 20.56 -76.14 REMARK 500 ALA C 806 68.49 62.11 REMARK 500 REMARK 500 THIS ENTRY HAS 119 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 PRO L 28 SER L 29 143.40 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY REMARK 500 REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME; REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 500 I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI ANGLE REMARK 500 ASP E 52 15.17 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-38451 RELATED DB: EMDB REMARK 900 STRUCTURE OF NATIVE GLUN1A-GLUN2A-GLUN1B-GLUN2B NMDA RECEPTOR IN REMARK 900 RAT CORTEX AND HIPPOCAMPUS REMARK 900 RELATED ID: 8XLK RELATED DB: PDB REMARK 900 STRUCTURE OF NATIVE TRI-HETEROMERIC GLUN1-GLUN2A-GLUN2B NMDA REMARK 900 RECEPTOR IN RAT CORTEX AND HIPPOCAMPUS REMARK 900 RELATED ID: EMD-61622 RELATED DB: EMDB REMARK 900 STRUCTURE OF NATIVE DI-HETEROMERIC GLUN1-GLUN2B NMDA RECEPTOR IN REMARK 900 RAT CORTEX AND HIPPOCAMPUS REMARK 900 RELATED ID: 9JNN RELATED DB: PDB REMARK 900 STRUCTURE OF NATIVE DI-HETEROMERIC GLUN1-GLUN2B NMDA RECEPTOR IN REMARK 900 RAT CORTEX AND HIPPOCAMPUS REMARK 900 RELATED ID: EMD-61623 RELATED DB: EMDB REMARK 900 STRUCTURE OF NATIVE DI-HETEROMERIC GLUN1-GLUN2A NMDA RECEPTOR IN REMARK 900 RAT CORTEX AND HIPPOCAMPUS DBREF 8XLK A 1 938 UNP P35439 NMDZ1_RAT 1 938 DBREF 8XLK B 1 1464 UNP Q00959 NMDE1_RAT 1 1464 DBREF 8XLK C 1 938 UNP P35439 NMDZ1_RAT 1 938 DBREF 8XLK D 1 1482 UNP Q00960 NMDE2_RAT 1 1482 DBREF 8XLK E -1 138 PDB 8XLK 8XLK -1 138 DBREF 8XLK F 0 130 PDB 8XLK 8XLK 0 130 DBREF 8XLK G 1 227 PDB 8XLK 8XLK 1 227 DBREF 8XLK H 1 212 PDB 8XLK 8XLK 1 212 DBREF 8XLK I -1 138 PDB 8XLK 8XLK -1 138 DBREF 8XLK J 0 130 PDB 8XLK 8XLK 0 130 DBREF 8XLK K 1 249 PDB 8XLK 8XLK 1 249 DBREF 8XLK L 1 265 PDB 8XLK 8XLK 1 265 SEQRES 1 A 938 MET SER THR MET HIS LEU LEU THR PHE ALA LEU LEU PHE SEQRES 2 A 938 SER CYS SER PHE ALA ARG ALA ALA CYS ASP PRO LYS ILE SEQRES 3 A 938 VAL ASN ILE GLY ALA VAL LEU SER THR ARG LYS HIS GLU SEQRES 4 A 938 GLN MET PHE ARG GLU ALA VAL ASN GLN ALA ASN LYS ARG SEQRES 5 A 938 HIS GLY SER TRP LYS ILE GLN LEU ASN ALA THR SER VAL SEQRES 6 A 938 THR HIS LYS PRO ASN ALA ILE GLN MET ALA LEU SER VAL SEQRES 7 A 938 CYS GLU ASP LEU ILE SER SER GLN VAL TYR ALA ILE LEU SEQRES 8 A 938 VAL SER HIS PRO PRO THR PRO ASN ASP HIS PHE THR PRO SEQRES 9 A 938 THR PRO VAL SER TYR THR ALA GLY PHE TYR ARG ILE PRO SEQRES 10 A 938 VAL LEU GLY LEU THR THR ARG MET SER ILE TYR SER ASP SEQRES 11 A 938 LYS SER ILE HIS LEU SER PHE LEU ARG THR VAL PRO PRO SEQRES 12 A 938 TYR SER HIS GLN SER SER VAL TRP PHE GLU MET MET ARG SEQRES 13 A 938 VAL TYR ASN TRP ASN HIS ILE ILE LEU LEU VAL SER ASP SEQRES 14 A 938 ASP HIS GLU GLY ARG ALA ALA GLN LYS ARG LEU GLU THR SEQRES 15 A 938 LEU LEU GLU GLU ARG GLU SER LYS ALA GLU LYS VAL LEU SEQRES 16 A 938 GLN PHE ASP PRO GLY THR LYS ASN VAL THR ALA LEU LEU SEQRES 17 A 938 MET GLU ALA ARG GLU LEU GLU ALA ARG VAL ILE ILE LEU SEQRES 18 A 938 SER ALA SER GLU ASP ASP ALA ALA THR VAL TYR ARG ALA SEQRES 19 A 938 ALA ALA MET LEU ASN MET THR GLY SER GLY TYR VAL TRP SEQRES 20 A 938 LEU VAL GLY GLU ARG GLU ILE SER GLY ASN ALA LEU ARG SEQRES 21 A 938 TYR ALA PRO ASP GLY ILE ILE GLY LEU GLN LEU ILE ASN SEQRES 22 A 938 GLY LYS ASN GLU SER ALA HIS ILE SER ASP ALA VAL GLY SEQRES 23 A 938 VAL VAL ALA GLN ALA VAL HIS GLU LEU LEU GLU LYS GLU SEQRES 24 A 938 ASN ILE THR ASP PRO PRO ARG GLY CYS VAL GLY ASN THR SEQRES 25 A 938 ASN ILE TRP LYS THR GLY PRO LEU PHE LYS ARG VAL LEU SEQRES 26 A 938 MET SER SER LYS TYR ALA ASP GLY VAL THR GLY ARG VAL SEQRES 27 A 938 GLU PHE ASN GLU ASP GLY ASP ARG LYS PHE ALA ASN TYR SEQRES 28 A 938 SER ILE MET ASN LEU GLN ASN ARG LYS LEU VAL GLN VAL SEQRES 29 A 938 GLY ILE TYR ASN GLY THR HIS VAL ILE PRO ASN ASP ARG SEQRES 30 A 938 LYS ILE ILE TRP PRO GLY GLY GLU THR GLU LYS PRO ARG SEQRES 31 A 938 GLY TYR GLN MET SER THR ARG LEU LYS ILE VAL THR ILE SEQRES 32 A 938 HIS GLN GLU PRO PHE VAL TYR VAL LYS PRO THR MET SER SEQRES 33 A 938 ASP GLY THR CYS LYS GLU GLU PHE THR VAL ASN GLY ASP SEQRES 34 A 938 PRO VAL LYS LYS VAL ILE CYS THR GLY PRO ASN ASP THR SEQRES 35 A 938 SER PRO GLY SER PRO ARG HIS THR VAL PRO GLN CYS CYS SEQRES 36 A 938 TYR GLY PHE CYS ILE ASP LEU LEU ILE LYS LEU ALA ARG SEQRES 37 A 938 THR MET ASN PHE THR TYR GLU VAL HIS LEU VAL ALA ASP SEQRES 38 A 938 GLY LYS PHE GLY THR GLN GLU ARG VAL ASN ASN SER ASN SEQRES 39 A 938 LYS LYS GLU TRP ASN GLY MET MET GLY GLU LEU LEU SER SEQRES 40 A 938 GLY GLN ALA ASP MET ILE VAL ALA PRO LEU THR ILE ASN SEQRES 41 A 938 ASN GLU ARG ALA GLN TYR ILE GLU PHE SER LYS PRO PHE SEQRES 42 A 938 LYS TYR GLN GLY LEU THR ILE LEU VAL LYS LYS GLU ILE SEQRES 43 A 938 PRO ARG SER THR LEU ASP SER PHE MET GLN PRO PHE GLN SEQRES 44 A 938 SER THR LEU TRP LEU LEU VAL GLY LEU SER VAL HIS VAL SEQRES 45 A 938 VAL ALA VAL MET LEU TYR LEU LEU ASP ARG PHE SER PRO SEQRES 46 A 938 PHE GLY ARG PHE LYS VAL ASN SER GLU GLU GLU GLU GLU SEQRES 47 A 938 ASP ALA LEU THR LEU SER SER ALA MET TRP PHE SER TRP SEQRES 48 A 938 GLY VAL LEU LEU ASN SER GLY ILE GLY GLU GLY ALA PRO SEQRES 49 A 938 ARG SER PHE SER ALA ARG ILE LEU GLY MET VAL TRP ALA SEQRES 50 A 938 GLY PHE ALA MET ILE ILE VAL ALA SER TYR THR ALA ASN SEQRES 51 A 938 LEU ALA ALA PHE LEU VAL LEU ASP ARG PRO GLU GLU ARG SEQRES 52 A 938 ILE THR GLY ILE ASN ASP PRO ARG LEU ARG ASN PRO SER SEQRES 53 A 938 ASP LYS PHE ILE TYR ALA THR VAL LYS GLN SER SER VAL SEQRES 54 A 938 ASP ILE TYR PHE ARG ARG GLN VAL GLU LEU SER THR MET SEQRES 55 A 938 TYR ARG HIS MET GLU LYS HIS ASN TYR GLU SER ALA ALA SEQRES 56 A 938 GLU ALA ILE GLN ALA VAL ARG ASP ASN LYS LEU HIS ALA SEQRES 57 A 938 PHE ILE TRP ASP SER ALA VAL LEU GLU PHE GLU ALA SER SEQRES 58 A 938 GLN LYS CYS ASP LEU VAL THR THR GLY GLU LEU PHE PHE SEQRES 59 A 938 ARG SER GLY PHE GLY ILE GLY MET ARG LYS ASP SER PRO SEQRES 60 A 938 TRP LYS GLN ASN VAL SER LEU SER ILE LEU LYS SER HIS SEQRES 61 A 938 GLU ASN GLY PHE MET GLU ASP LEU ASP LYS THR TRP VAL SEQRES 62 A 938 ARG TYR GLN GLU CYS ASP SER ARG SER ASN ALA PRO ALA SEQRES 63 A 938 THR LEU THR PHE GLU ASN MET ALA GLY VAL PHE MET LEU SEQRES 64 A 938 VAL ALA GLY GLY ILE VAL ALA GLY ILE PHE LEU ILE PHE SEQRES 65 A 938 ILE GLU ILE ALA TYR LYS ARG HIS LYS ASP ALA ARG ARG SEQRES 66 A 938 LYS GLN MET GLN LEU ALA PHE ALA ALA VAL ASN VAL TRP SEQRES 67 A 938 ARG LYS ASN LEU GLN ASP ARG LYS SER GLY ARG ALA GLU SEQRES 68 A 938 PRO ASP PRO LYS LYS LYS ALA THR PHE ARG ALA ILE THR SEQRES 69 A 938 SER THR LEU ALA SER SER PHE LYS ARG ARG ARG SER SER SEQRES 70 A 938 LYS ASP THR SER THR GLY GLY GLY ARG GLY ALA LEU GLN SEQRES 71 A 938 ASN GLN LYS ASP THR VAL LEU PRO ARG ARG ALA ILE GLU SEQRES 72 A 938 ARG GLU GLU GLY GLN LEU GLN LEU CYS SER ARG HIS ARG SEQRES 73 A 938 GLU SER SEQRES 1 B 1464 MET GLY ARG LEU GLY TYR TRP THR LEU LEU VAL LEU PRO SEQRES 2 B 1464 ALA LEU LEU VAL TRP ARG ASP PRO ALA GLN ASN ALA ALA SEQRES 3 B 1464 ALA GLU LYS GLY PRO PRO ALA LEU ASN ILE ALA VAL LEU SEQRES 4 B 1464 LEU GLY HIS SER HIS ASP VAL THR GLU ARG GLU LEU ARG SEQRES 5 B 1464 ASN LEU TRP GLY PRO GLU GLN ALA THR GLY LEU PRO LEU SEQRES 6 B 1464 ASP VAL ASN VAL VAL ALA LEU LEU MET ASN ARG THR ASP SEQRES 7 B 1464 PRO LYS SER LEU ILE THR HIS VAL CYS ASP LEU MET SER SEQRES 8 B 1464 GLY ALA ARG ILE HIS GLY LEU VAL PHE GLY ASP ASP THR SEQRES 9 B 1464 ASP GLN GLU ALA VAL ALA GLN MET LEU ASP PHE ILE SER SEQRES 10 B 1464 SER GLN THR PHE ILE PRO ILE LEU GLY ILE HIS GLY GLY SEQRES 11 B 1464 ALA SER MET ILE MET ALA ASP LYS ASP PRO THR SER THR SEQRES 12 B 1464 PHE PHE GLN PHE GLY ALA SER ILE GLN GLN GLN ALA THR SEQRES 13 B 1464 VAL MET LEU LYS ILE MET GLN ASP TYR ASP TRP HIS VAL SEQRES 14 B 1464 PHE SER LEU VAL THR THR ILE PHE PRO GLY TYR ARG ASP SEQRES 15 B 1464 PHE ILE SER PHE ILE LYS THR THR VAL ASP ASN SER PHE SEQRES 16 B 1464 VAL GLY TRP ASP MET GLN ASN VAL ILE THR LEU ASP THR SEQRES 17 B 1464 SER PHE GLU ASP ALA LYS THR GLN VAL GLN LEU LYS LYS SEQRES 18 B 1464 ILE HIS SER SER VAL ILE LEU LEU TYR CYS SER LYS ASP SEQRES 19 B 1464 GLU ALA VAL LEU ILE LEU SER GLU ALA ARG SER LEU GLY SEQRES 20 B 1464 LEU THR GLY TYR ASP PHE PHE TRP ILE VAL PRO SER LEU SEQRES 21 B 1464 VAL SER GLY ASN THR GLU LEU ILE PRO LYS GLU PHE PRO SEQRES 22 B 1464 SER GLY LEU ILE SER VAL SER TYR ASP ASP TRP ASP TYR SEQRES 23 B 1464 SER LEU GLU ALA ARG VAL ARG ASP GLY LEU GLY ILE LEU SEQRES 24 B 1464 THR THR ALA ALA SER SER MET LEU GLU LYS PHE SER TYR SEQRES 25 B 1464 ILE PRO GLU ALA LYS ALA SER CYS TYR GLY GLN ALA GLU SEQRES 26 B 1464 LYS PRO GLU THR PRO LEU HIS THR LEU HIS GLN PHE MET SEQRES 27 B 1464 VAL ASN VAL THR TRP ASP GLY LYS ASP LEU SER PHE THR SEQRES 28 B 1464 GLU GLU GLY TYR GLN VAL HIS PRO ARG LEU VAL VAL ILE SEQRES 29 B 1464 VAL LEU ASN LYS ASP ARG GLU TRP GLU LYS VAL GLY LYS SEQRES 30 B 1464 TRP GLU ASN GLN THR LEU SER LEU ARG HIS ALA VAL TRP SEQRES 31 B 1464 PRO ARG TYR LYS SER PHE SER ASP CYS GLU PRO ASP ASP SEQRES 32 B 1464 ASN HIS LEU SER ILE VAL THR LEU GLU GLU ALA PRO PHE SEQRES 33 B 1464 VAL ILE VAL GLU ASP ILE ASP PRO LEU THR GLU THR CYS SEQRES 34 B 1464 VAL ARG ASN THR VAL PRO CYS ARG LYS PHE VAL LYS ILE SEQRES 35 B 1464 ASN ASN SER THR ASN GLU GLY MET ASN VAL LYS LYS CYS SEQRES 36 B 1464 CYS LYS GLY PHE CYS ILE ASP ILE LEU LYS LYS LEU SER SEQRES 37 B 1464 ARG THR VAL LYS PHE THR TYR ASP LEU TYR LEU VAL THR SEQRES 38 B 1464 ASN GLY LYS HIS GLY LYS LYS VAL ASN ASN VAL TRP ASN SEQRES 39 B 1464 GLY MET ILE GLY GLU VAL VAL TYR GLN ARG ALA VAL MET SEQRES 40 B 1464 ALA VAL GLY SER LEU THR ILE ASN GLU GLU ARG SER GLU SEQRES 41 B 1464 VAL VAL ASP PHE SER VAL PRO PHE VAL GLU THR GLY ILE SEQRES 42 B 1464 SER VAL MET VAL SER ARG SER ASN GLY THR VAL SER PRO SEQRES 43 B 1464 SER ALA PHE LEU GLU PRO PHE SER ALA SER VAL TRP VAL SEQRES 44 B 1464 MET MET PHE VAL MET LEU LEU ILE VAL SER ALA ILE ALA SEQRES 45 B 1464 VAL PHE VAL PHE GLU TYR PHE SER PRO VAL GLY TYR ASN SEQRES 46 B 1464 ARG ASN LEU ALA LYS GLY LYS ALA PRO HIS GLY PRO SER SEQRES 47 B 1464 PHE THR ILE GLY LYS ALA ILE TRP LEU LEU TRP GLY LEU SEQRES 48 B 1464 VAL PHE ASN ASN SER VAL PRO VAL GLN ASN PRO LYS GLY SEQRES 49 B 1464 THR THR SER LYS ILE MET VAL SER VAL TRP ALA PHE PHE SEQRES 50 B 1464 ALA VAL ILE PHE LEU ALA SER TYR THR ALA ASN LEU ALA SEQRES 51 B 1464 ALA PHE MET ILE GLN GLU GLU PHE VAL ASP GLN VAL THR SEQRES 52 B 1464 GLY LEU SER ASP LYS LYS PHE GLN ARG PRO HIS ASP TYR SEQRES 53 B 1464 SER PRO PRO PHE ARG PHE GLY THR VAL PRO ASN GLY SER SEQRES 54 B 1464 THR GLU ARG ASN ILE ARG ASN ASN TYR PRO TYR MET HIS SEQRES 55 B 1464 GLN TYR MET THR ARG PHE ASN GLN ARG GLY VAL GLU ASP SEQRES 56 B 1464 ALA LEU VAL SER LEU LYS THR GLY LYS LEU ASP ALA PHE SEQRES 57 B 1464 ILE TYR ASP ALA ALA VAL LEU ASN TYR LYS ALA GLY ARG SEQRES 58 B 1464 ASP GLU GLY CYS LYS LEU VAL THR ILE GLY SER GLY TYR SEQRES 59 B 1464 ILE PHE ALA SER THR GLY TYR GLY ILE ALA LEU GLN LYS SEQRES 60 B 1464 GLY SER PRO TRP LYS ARG GLN ILE ASP LEU ALA LEU LEU SEQRES 61 B 1464 GLN PHE VAL GLY ASP GLY GLU MET GLU GLU LEU GLU THR SEQRES 62 B 1464 LEU TRP LEU THR GLY ILE CYS HIS ASN GLU LYS ASN GLU SEQRES 63 B 1464 VAL MET SER SER GLN LEU ASP ILE ASP ASN MET ALA GLY SEQRES 64 B 1464 VAL PHE TYR MET LEU ALA ALA ALA MET ALA LEU SER LEU SEQRES 65 B 1464 ILE THR PHE ILE TRP GLU HIS LEU PHE TYR TRP LYS LEU SEQRES 66 B 1464 ARG PHE CYS PHE THR GLY VAL CYS SER ASP ARG PRO GLY SEQRES 67 B 1464 LEU LEU PHE SER ILE SER ARG GLY ILE TYR SER CYS ILE SEQRES 68 B 1464 HIS GLY VAL HIS ILE GLU GLU LYS LYS LYS SER PRO ASP SEQRES 69 B 1464 PHE ASN LEU THR GLY SER GLN SER ASN MET LEU LYS LEU SEQRES 70 B 1464 LEU ARG SER ALA LYS ASN ILE SER ASN MET SER ASN MET SEQRES 71 B 1464 ASN SER SER ARG MET ASP SER PRO LYS ARG ALA THR ASP SEQRES 72 B 1464 PHE ILE GLN ARG GLY SER LEU ILE VAL ASP MET VAL SER SEQRES 73 B 1464 ASP LYS GLY ASN LEU ILE TYR SER ASP ASN ARG SER PHE SEQRES 74 B 1464 GLN GLY LYS ASP SER ILE PHE GLY ASP ASN MET ASN GLU SEQRES 75 B 1464 LEU GLN THR PHE VAL ALA ASN ARG HIS LYS ASP ASN LEU SEQRES 76 B 1464 SER ASN TYR VAL PHE GLN GLY GLN HIS PRO LEU THR LEU SEQRES 77 B 1464 ASN GLU SER ASN PRO ASN THR VAL GLU VAL ALA VAL SER SEQRES 78 B 1464 THR GLU SER LYS GLY ASN SER ARG PRO ARG GLN LEU TRP SEQRES 79 B 1464 LYS LYS SER MET GLU SER LEU ARG GLN ASP SER LEU ASN SEQRES 80 B 1464 GLN ASN PRO VAL SER GLN ARG ASP GLU LYS THR ALA GLU SEQRES 81 B 1464 ASN ARG THR HIS SER LEU LYS SER PRO ARG TYR LEU PRO SEQRES 82 B 1464 GLU GLU VAL ALA HIS SER ASP ILE SER GLU THR SER SER SEQRES 83 B 1464 ARG ALA THR CYS HIS ARG GLU PRO ASP ASN ASN LYS ASN SEQRES 84 B 1464 HIS LYS THR LYS ASP ASN PHE LYS ARG SER MET ALA SER SEQRES 85 B 1464 LYS TYR PRO LYS ASP CYS SER ASP VAL ASP ARG THR TYR SEQRES 86 B 1464 MET LYS THR LYS ALA SER SER PRO ARG ASP LYS ILE TYR SEQRES 87 B 1464 THR ILE ASP GLY GLU LYS GLU PRO SER PHE HIS LEU ASP SEQRES 88 B 1464 PRO PRO GLN PHE VAL GLU ASN ILE THR LEU PRO GLU ASN SEQRES 89 B 1464 VAL GLY PHE PRO ASP THR TYR GLN ASP HIS ASN GLU ASN SEQRES 90 B 1464 PHE ARG LYS GLY ASP SER THR LEU PRO MET ASN ARG ASN SEQRES 91 B 1464 PRO LEU HIS ASN GLU ASP GLY LEU PRO ASN ASN ASP GLN SEQRES 92 B 1464 TYR LYS LEU TYR ALA LYS HIS PHE THR LEU LYS ASP LYS SEQRES 93 B 1464 GLY SER PRO HIS SER GLU GLY SER ASP ARG TYR ARG GLN SEQRES 94 B 1464 ASN SER THR HIS CYS ARG SER CYS LEU SER ASN LEU PRO SEQRES 95 B 1464 THR TYR SER GLY HIS PHE THR MET ARG SER PRO PHE LYS SEQRES 96 B 1464 CYS ASP ALA CYS LEU ARG MET GLY ASN LEU TYR ASP ILE SEQRES 97 B 1464 ASP GLU ASP GLN MET LEU GLN GLU THR GLY ASN PRO ALA SEQRES 98 B 1464 THR ARG GLU GLU VAL TYR GLN GLN ASP TRP SER GLN ASN SEQRES 99 B 1464 ASN ALA LEU GLN PHE GLN LYS ASN LYS LEU ARG ILE ASN SEQRES 100 B 1464 ARG GLN HIS SER TYR ASP ASN ILE LEU ASP LYS PRO ARG SEQRES 101 B 1464 GLU ILE ASP LEU SER ARG PRO SER ARG SER ILE SER LEU SEQRES 102 B 1464 LYS ASP ARG GLU ARG LEU LEU GLU GLY ASN LEU TYR GLY SEQRES 103 B 1464 SER LEU PHE SER VAL PRO SER SER LYS LEU LEU GLY ASN SEQRES 104 B 1464 LYS SER SER LEU PHE PRO GLN GLY LEU GLU ASP SER LYS SEQRES 105 B 1464 ARG SER LYS SER LEU LEU PRO ASP HIS ALA SER ASP ASN SEQRES 106 B 1464 PRO PHE LEU HIS THR TYR GLY ASP ASP GLN ARG LEU VAL SEQRES 107 B 1464 ILE GLY ARG CYS PRO SER ASP PRO TYR LYS HIS SER LEU SEQRES 108 B 1464 PRO SER GLN ALA VAL ASN ASP SER TYR LEU ARG SER SER SEQRES 109 B 1464 LEU ARG SER THR ALA SER TYR CYS SER ARG ASP SER ARG SEQRES 110 B 1464 GLY HIS SER ASP VAL TYR ILE SER GLU HIS VAL MET PRO SEQRES 111 B 1464 TYR ALA ALA ASN LYS ASN THR MET TYR SER THR PRO ARG SEQRES 112 B 1464 VAL LEU ASN SER CYS SER ASN ARG ARG VAL TYR LYS LYS SEQRES 113 B 1464 MET PRO SER ILE GLU SER ASP VAL SEQRES 1 C 938 MET SER THR MET HIS LEU LEU THR PHE ALA LEU LEU PHE SEQRES 2 C 938 SER CYS SER PHE ALA ARG ALA ALA CYS ASP PRO LYS ILE SEQRES 3 C 938 VAL ASN ILE GLY ALA VAL LEU SER THR ARG LYS HIS GLU SEQRES 4 C 938 GLN MET PHE ARG GLU ALA VAL ASN GLN ALA ASN LYS ARG SEQRES 5 C 938 HIS GLY SER TRP LYS ILE GLN LEU ASN ALA THR SER VAL SEQRES 6 C 938 THR HIS LYS PRO ASN ALA ILE GLN MET ALA LEU SER VAL SEQRES 7 C 938 CYS GLU ASP LEU ILE SER SER GLN VAL TYR ALA ILE LEU SEQRES 8 C 938 VAL SER HIS PRO PRO THR PRO ASN ASP HIS PHE THR PRO SEQRES 9 C 938 THR PRO VAL SER TYR THR ALA GLY PHE TYR ARG ILE PRO SEQRES 10 C 938 VAL LEU GLY LEU THR THR ARG MET SER ILE TYR SER ASP SEQRES 11 C 938 LYS SER ILE HIS LEU SER PHE LEU ARG THR VAL PRO PRO SEQRES 12 C 938 TYR SER HIS GLN SER SER VAL TRP PHE GLU MET MET ARG SEQRES 13 C 938 VAL TYR ASN TRP ASN HIS ILE ILE LEU LEU VAL SER ASP SEQRES 14 C 938 ASP HIS GLU GLY ARG ALA ALA GLN LYS ARG LEU GLU THR SEQRES 15 C 938 LEU LEU GLU GLU ARG GLU SER LYS ALA GLU LYS VAL LEU SEQRES 16 C 938 GLN PHE ASP PRO GLY THR LYS ASN VAL THR ALA LEU LEU SEQRES 17 C 938 MET GLU ALA ARG GLU LEU GLU ALA ARG VAL ILE ILE LEU SEQRES 18 C 938 SER ALA SER GLU ASP ASP ALA ALA THR VAL TYR ARG ALA SEQRES 19 C 938 ALA ALA MET LEU ASN MET THR GLY SER GLY TYR VAL TRP SEQRES 20 C 938 LEU VAL GLY GLU ARG GLU ILE SER GLY ASN ALA LEU ARG SEQRES 21 C 938 TYR ALA PRO ASP GLY ILE ILE GLY LEU GLN LEU ILE ASN SEQRES 22 C 938 GLY LYS ASN GLU SER ALA HIS ILE SER ASP ALA VAL GLY SEQRES 23 C 938 VAL VAL ALA GLN ALA VAL HIS GLU LEU LEU GLU LYS GLU SEQRES 24 C 938 ASN ILE THR ASP PRO PRO ARG GLY CYS VAL GLY ASN THR SEQRES 25 C 938 ASN ILE TRP LYS THR GLY PRO LEU PHE LYS ARG VAL LEU SEQRES 26 C 938 MET SER SER LYS TYR ALA ASP GLY VAL THR GLY ARG VAL SEQRES 27 C 938 GLU PHE ASN GLU ASP GLY ASP ARG LYS PHE ALA ASN TYR SEQRES 28 C 938 SER ILE MET ASN LEU GLN ASN ARG LYS LEU VAL GLN VAL SEQRES 29 C 938 GLY ILE TYR ASN GLY THR HIS VAL ILE PRO ASN ASP ARG SEQRES 30 C 938 LYS ILE ILE TRP PRO GLY GLY GLU THR GLU LYS PRO ARG SEQRES 31 C 938 GLY TYR GLN MET SER THR ARG LEU LYS ILE VAL THR ILE SEQRES 32 C 938 HIS GLN GLU PRO PHE VAL TYR VAL LYS PRO THR MET SER SEQRES 33 C 938 ASP GLY THR CYS LYS GLU GLU PHE THR VAL ASN GLY ASP SEQRES 34 C 938 PRO VAL LYS LYS VAL ILE CYS THR GLY PRO ASN ASP THR SEQRES 35 C 938 SER PRO GLY SER PRO ARG HIS THR VAL PRO GLN CYS CYS SEQRES 36 C 938 TYR GLY PHE CYS ILE ASP LEU LEU ILE LYS LEU ALA ARG SEQRES 37 C 938 THR MET ASN PHE THR TYR GLU VAL HIS LEU VAL ALA ASP SEQRES 38 C 938 GLY LYS PHE GLY THR GLN GLU ARG VAL ASN ASN SER ASN SEQRES 39 C 938 LYS LYS GLU TRP ASN GLY MET MET GLY GLU LEU LEU SER SEQRES 40 C 938 GLY GLN ALA ASP MET ILE VAL ALA PRO LEU THR ILE ASN SEQRES 41 C 938 ASN GLU ARG ALA GLN TYR ILE GLU PHE SER LYS PRO PHE SEQRES 42 C 938 LYS TYR GLN GLY LEU THR ILE LEU VAL LYS LYS GLU ILE SEQRES 43 C 938 PRO ARG SER THR LEU ASP SER PHE MET GLN PRO PHE GLN SEQRES 44 C 938 SER THR LEU TRP LEU LEU VAL GLY LEU SER VAL HIS VAL SEQRES 45 C 938 VAL ALA VAL MET LEU TYR LEU LEU ASP ARG PHE SER PRO SEQRES 46 C 938 PHE GLY ARG PHE LYS VAL ASN SER GLU GLU GLU GLU GLU SEQRES 47 C 938 ASP ALA LEU THR LEU SER SER ALA MET TRP PHE SER TRP SEQRES 48 C 938 GLY VAL LEU LEU ASN SER GLY ILE GLY GLU GLY ALA PRO SEQRES 49 C 938 ARG SER PHE SER ALA ARG ILE LEU GLY MET VAL TRP ALA SEQRES 50 C 938 GLY PHE ALA MET ILE ILE VAL ALA SER TYR THR ALA ASN SEQRES 51 C 938 LEU ALA ALA PHE LEU VAL LEU ASP ARG PRO GLU GLU ARG SEQRES 52 C 938 ILE THR GLY ILE ASN ASP PRO ARG LEU ARG ASN PRO SER SEQRES 53 C 938 ASP LYS PHE ILE TYR ALA THR VAL LYS GLN SER SER VAL SEQRES 54 C 938 ASP ILE TYR PHE ARG ARG GLN VAL GLU LEU SER THR MET SEQRES 55 C 938 TYR ARG HIS MET GLU LYS HIS ASN TYR GLU SER ALA ALA SEQRES 56 C 938 GLU ALA ILE GLN ALA VAL ARG ASP ASN LYS LEU HIS ALA SEQRES 57 C 938 PHE ILE TRP ASP SER ALA VAL LEU GLU PHE GLU ALA SER SEQRES 58 C 938 GLN LYS CYS ASP LEU VAL THR THR GLY GLU LEU PHE PHE SEQRES 59 C 938 ARG SER GLY PHE GLY ILE GLY MET ARG LYS ASP SER PRO SEQRES 60 C 938 TRP LYS GLN ASN VAL SER LEU SER ILE LEU LYS SER HIS SEQRES 61 C 938 GLU ASN GLY PHE MET GLU ASP LEU ASP LYS THR TRP VAL SEQRES 62 C 938 ARG TYR GLN GLU CYS ASP SER ARG SER ASN ALA PRO ALA SEQRES 63 C 938 THR LEU THR PHE GLU ASN MET ALA GLY VAL PHE MET LEU SEQRES 64 C 938 VAL ALA GLY GLY ILE VAL ALA GLY ILE PHE LEU ILE PHE SEQRES 65 C 938 ILE GLU ILE ALA TYR LYS ARG HIS LYS ASP ALA ARG ARG SEQRES 66 C 938 LYS GLN MET GLN LEU ALA PHE ALA ALA VAL ASN VAL TRP SEQRES 67 C 938 ARG LYS ASN LEU GLN ASP ARG LYS SER GLY ARG ALA GLU SEQRES 68 C 938 PRO ASP PRO LYS LYS LYS ALA THR PHE ARG ALA ILE THR SEQRES 69 C 938 SER THR LEU ALA SER SER PHE LYS ARG ARG ARG SER SER SEQRES 70 C 938 LYS ASP THR SER THR GLY GLY GLY ARG GLY ALA LEU GLN SEQRES 71 C 938 ASN GLN LYS ASP THR VAL LEU PRO ARG ARG ALA ILE GLU SEQRES 72 C 938 ARG GLU GLU GLY GLN LEU GLN LEU CYS SER ARG HIS ARG SEQRES 73 C 938 GLU SER SEQRES 1 D 1482 MET LYS PRO SER ALA GLU CYS CYS SER PRO LYS PHE TRP SEQRES 2 D 1482 LEU VAL LEU ALA VAL LEU ALA VAL SER GLY SER LYS ALA SEQRES 3 D 1482 ARG SER GLN LYS SER PRO PRO SER ILE GLY ILE ALA VAL SEQRES 4 D 1482 ILE LEU VAL GLY THR SER ASP GLU VAL ALA ILE LYS ASP SEQRES 5 D 1482 ALA HIS GLU LYS ASP ASP PHE HIS HIS LEU SER VAL VAL SEQRES 6 D 1482 PRO ARG VAL GLU LEU VAL ALA MET ASN GLU THR ASP PRO SEQRES 7 D 1482 LYS SER ILE ILE THR ARG ILE CYS ASP LEU MET SER ASP SEQRES 8 D 1482 ARG LYS ILE GLN GLY VAL VAL PHE ALA ASP ASP THR ASP SEQRES 9 D 1482 GLN GLU ALA ILE ALA GLN ILE LEU ASP PHE ILE SER ALA SEQRES 10 D 1482 GLN THR LEU THR PRO ILE LEU GLY ILE HIS GLY GLY SER SEQRES 11 D 1482 SER MET ILE MET ALA ASP LYS ASP GLU SER SER MET PHE SEQRES 12 D 1482 PHE GLN PHE GLY PRO SER ILE GLU GLN GLN ALA SER VAL SEQRES 13 D 1482 MET LEU ASN ILE MET GLU GLU TYR ASP TRP TYR ILE PHE SEQRES 14 D 1482 SER ILE VAL THR THR TYR PHE PRO GLY TYR GLN ASP PHE SEQRES 15 D 1482 VAL ASN LYS ILE ARG SER THR ILE GLU ASN SER PHE VAL SEQRES 16 D 1482 GLY TRP GLU LEU GLU GLU VAL LEU LEU LEU ASP MET SER SEQRES 17 D 1482 LEU ASP ASP GLY ASP SER LYS ILE GLN ASN GLN LEU LYS SEQRES 18 D 1482 LYS LEU GLN SER PRO ILE ILE LEU LEU TYR CYS THR LYS SEQRES 19 D 1482 GLU GLU ALA THR TYR ILE PHE GLU VAL ALA ASN SER VAL SEQRES 20 D 1482 GLY LEU THR GLY TYR GLY TYR THR TRP ILE VAL PRO SER SEQRES 21 D 1482 LEU VAL ALA GLY ASP THR ASP THR VAL PRO SER GLU PHE SEQRES 22 D 1482 PRO THR GLY LEU ILE SER VAL SER TYR ASP GLU TRP ASP SEQRES 23 D 1482 TYR GLY LEU PRO ALA ARG VAL ARG ASP GLY ILE ALA ILE SEQRES 24 D 1482 ILE THR THR ALA ALA SER ASP MET LEU SER GLU HIS SER SEQRES 25 D 1482 PHE ILE PRO GLU PRO LYS SER SER CYS TYR ASN THR HIS SEQRES 26 D 1482 GLU LYS ARG ILE TYR GLN SER ASN MET LEU ASN ARG TYR SEQRES 27 D 1482 LEU ILE ASN VAL THR PHE GLU GLY ARG ASN LEU SER PHE SEQRES 28 D 1482 SER GLU ASP GLY TYR GLN MET HIS PRO LYS LEU VAL ILE SEQRES 29 D 1482 ILE LEU LEU ASN LYS GLU ARG LYS TRP GLU ARG VAL GLY SEQRES 30 D 1482 LYS TRP LYS ASP LYS SER LEU GLN MET LYS TYR TYR VAL SEQRES 31 D 1482 TRP PRO ARG MET CYS PRO GLU THR GLU GLU GLN GLU ASP SEQRES 32 D 1482 ASP HIS LEU SER ILE VAL THR LEU GLU GLU ALA PRO PHE SEQRES 33 D 1482 VAL ILE VAL GLU SER VAL ASP PRO LEU SER GLY THR CYS SEQRES 34 D 1482 MET ARG ASN THR VAL PRO CYS GLN LYS ARG ILE ILE SER SEQRES 35 D 1482 GLU ASN LYS THR ASP GLU GLU PRO GLY TYR ILE LYS LYS SEQRES 36 D 1482 CYS CYS LYS GLY PHE CYS ILE ASP ILE LEU LYS LYS ILE SEQRES 37 D 1482 SER LYS SER VAL LYS PHE THR TYR ASP LEU TYR LEU VAL SEQRES 38 D 1482 THR ASN GLY LYS HIS GLY LYS LYS ILE ASN GLY THR TRP SEQRES 39 D 1482 ASN GLY MET ILE GLY GLU VAL VAL MET LYS ARG ALA TYR SEQRES 40 D 1482 MET ALA VAL GLY SER LEU THR ILE ASN GLU GLU ARG SER SEQRES 41 D 1482 GLU VAL VAL ASP PHE SER VAL PRO PHE ILE GLU THR GLY SEQRES 42 D 1482 ILE SER VAL MET VAL SER ARG SER ASN GLY THR VAL SER SEQRES 43 D 1482 PRO SER ALA PHE LEU GLU PRO PHE SER ALA ASP VAL TRP SEQRES 44 D 1482 VAL MET MET PHE VAL MET LEU LEU ILE VAL SER ALA VAL SEQRES 45 D 1482 ALA VAL PHE VAL PHE GLU TYR PHE SER PRO VAL GLY TYR SEQRES 46 D 1482 ASN ARG CYS LEU ALA ASP GLY ARG GLU PRO GLY GLY PRO SEQRES 47 D 1482 SER PHE THR ILE GLY LYS ALA ILE TRP LEU LEU TRP GLY SEQRES 48 D 1482 LEU VAL PHE ASN ASN SER VAL PRO VAL GLN ASN PRO LYS SEQRES 49 D 1482 GLY THR THR SER LYS ILE MET VAL SER VAL TRP ALA PHE SEQRES 50 D 1482 PHE ALA VAL ILE PHE LEU ALA SER TYR THR ALA ASN LEU SEQRES 51 D 1482 ALA ALA PHE MET ILE GLN GLU GLU TYR VAL ASP GLN VAL SEQRES 52 D 1482 SER GLY LEU SER ASP LYS LYS PHE GLN ARG PRO ASN ASP SEQRES 53 D 1482 PHE SER PRO PRO PHE ARG PHE GLY THR VAL PRO ASN GLY SEQRES 54 D 1482 SER THR GLU ARG ASN ILE ARG ASN ASN TYR ALA GLU MET SEQRES 55 D 1482 HIS ALA TYR MET GLY LYS PHE ASN GLN ARG GLY VAL ASP SEQRES 56 D 1482 ASP ALA LEU LEU SER LEU LYS THR GLY LYS LEU ASP ALA SEQRES 57 D 1482 PHE ILE TYR ASP ALA ALA VAL LEU ASN TYR MET ALA GLY SEQRES 58 D 1482 ARG ASP GLU GLY CYS LYS LEU VAL THR ILE GLY SER GLY SEQRES 59 D 1482 LYS VAL PHE ALA SER THR GLY TYR GLY ILE ALA ILE GLN SEQRES 60 D 1482 LYS ASP SER GLY TRP LYS ARG GLN VAL ASP LEU ALA ILE SEQRES 61 D 1482 LEU GLN LEU PHE GLY ASP GLY GLU MET GLU GLU LEU GLU SEQRES 62 D 1482 ALA LEU TRP LEU THR GLY ILE CYS HIS ASN GLU LYS ASN SEQRES 63 D 1482 GLU VAL MET SER SER GLN LEU ASP ILE ASP ASN MET ALA SEQRES 64 D 1482 GLY VAL PHE TYR MET LEU GLY ALA ALA MET ALA LEU SER SEQRES 65 D 1482 LEU ILE THR PHE ILE CYS GLU HIS LEU PHE TYR TRP GLN SEQRES 66 D 1482 PHE ARG HIS CYS PHE MET GLY VAL CYS SER GLY LYS PRO SEQRES 67 D 1482 GLY MET VAL PHE SER ILE SER ARG GLY ILE TYR SER CYS SEQRES 68 D 1482 ILE HIS GLY VAL ALA ILE GLU GLU ARG GLN SER VAL MET SEQRES 69 D 1482 ASN SER PRO THR ALA THR MET ASN ASN THR HIS SER ASN SEQRES 70 D 1482 ILE LEU ARG LEU LEU ARG THR ALA LYS ASN MET ALA ASN SEQRES 71 D 1482 LEU SER GLY VAL ASN GLY SER PRO GLN SER ALA LEU ASP SEQRES 72 D 1482 PHE ILE ARG ARG GLU SER SER VAL TYR ASP ILE SER GLU SEQRES 73 D 1482 HIS ARG ARG SER PHE THR HIS SER ASP CYS LYS SER TYR SEQRES 74 D 1482 ASN ASN PRO PRO CYS GLU GLU ASN LEU PHE SER ASP TYR SEQRES 75 D 1482 ILE SER GLU VAL GLU ARG THR PHE GLY ASN LEU GLN LEU SEQRES 76 D 1482 LYS ASP SER ASN VAL TYR GLN ASP HIS TYR HIS HIS HIS SEQRES 77 D 1482 HIS ARG PRO HIS SER ILE GLY SER THR SER SER ILE ASP SEQRES 78 D 1482 GLY LEU TYR ASP CYS ASP ASN PRO PRO PHE THR THR GLN SEQRES 79 D 1482 PRO ARG SER ILE SER LYS LYS PRO LEU ASP ILE GLY LEU SEQRES 80 D 1482 PRO SER SER LYS HIS SER GLN LEU SER ASP LEU TYR GLY SEQRES 81 D 1482 LYS PHE SER PHE LYS SER ASP ARG TYR SER GLY HIS ASP SEQRES 82 D 1482 ASP LEU ILE ARG SER ASP VAL SER ASP ILE SER THR HIS SEQRES 83 D 1482 THR VAL THR TYR GLY ASN ILE GLU GLY ASN ALA ALA LYS SEQRES 84 D 1482 ARG ARG LYS GLN GLN TYR LYS ASP SER LEU LYS LYS ARG SEQRES 85 D 1482 PRO ALA SER ALA LYS SER ARG ARG GLU PHE ASP GLU ILE SEQRES 86 D 1482 GLU LEU ALA TYR ARG ARG ARG PRO PRO ARG SER PRO ASP SEQRES 87 D 1482 HIS LYS ARG TYR PHE ARG ASP LYS GLU GLY LEU ARG ASP SEQRES 88 D 1482 PHE TYR LEU ASP GLN PHE ARG THR LYS GLU ASN SER PRO SEQRES 89 D 1482 HIS TRP GLU HIS VAL ASP LEU THR ASP ILE TYR LYS GLU SEQRES 90 D 1482 ARG SER ASP ASP PHE LYS ARG ASP SER VAL SER GLY GLY SEQRES 91 D 1482 GLY PRO CYS THR ASN ARG SER HIS LEU LYS HIS GLY THR SEQRES 92 D 1482 GLY GLU LYS HIS GLY VAL VAL GLY GLY VAL PRO ALA PRO SEQRES 93 D 1482 TRP GLU LYS ASN LEU THR ASN VAL ASP TRP GLU ASP ARG SEQRES 94 D 1482 SER GLY GLY ASN PHE CYS ARG SER CYS PRO SER LYS LEU SEQRES 95 D 1482 HIS ASN TYR SER SER THR VAL ALA GLY GLN ASN SER GLY SEQRES 96 D 1482 ARG GLN ALA CYS ILE ARG CYS GLU ALA CYS LYS LYS ALA SEQRES 97 D 1482 GLY ASN LEU TYR ASP ILE SER GLU ASP ASN SER LEU GLN SEQRES 98 D 1482 GLU LEU ASP GLN PRO ALA ALA PRO VAL ALA VAL THR SER SEQRES 99 D 1482 ASN ALA SER SER THR LYS TYR PRO GLN SER PRO THR ASN SEQRES 100 D 1482 SER LYS ALA GLN LYS LYS ASN ARG ASN LYS LEU ARG ARG SEQRES 101 D 1482 GLN HIS SER TYR ASP THR PHE VAL ASP LEU GLN LYS GLU SEQRES 102 D 1482 GLU ALA ALA LEU ALA PRO ARG SER VAL SER LEU LYS ASP SEQRES 103 D 1482 LYS GLY ARG PHE MET ASP GLY SER PRO TYR ALA HIS MET SEQRES 104 D 1482 PHE GLU MET PRO ALA GLY GLU SER SER PHE ALA ASN LYS SEQRES 105 D 1482 SER SER VAL PRO THR ALA GLY HIS HIS HIS ASN ASN PRO SEQRES 106 D 1482 GLY SER GLY TYR MET LEU SER LYS SER LEU TYR PRO ASP SEQRES 107 D 1482 ARG VAL THR GLN ASN PRO PHE ILE PRO THR PHE GLY ASP SEQRES 108 D 1482 ASP GLN CYS LEU LEU HIS GLY SER LYS SER TYR PHE PHE SEQRES 109 D 1482 ARG GLN PRO THR VAL ALA GLY ALA SER LYS THR ARG PRO SEQRES 110 D 1482 ASP PHE ARG ALA LEU VAL THR ASN LYS PRO VAL VAL VAL SEQRES 111 D 1482 THR LEU HIS GLY ALA VAL PRO GLY ARG PHE GLN LYS ASP SEQRES 112 D 1482 ILE CYS ILE GLY ASN GLN SER ASN PRO CYS VAL PRO ASN SEQRES 113 D 1482 ASN LYS ASN PRO ARG ALA PHE ASN GLY SER SER ASN GLY SEQRES 114 D 1482 HIS VAL TYR GLU LYS LEU SER SER ILE GLU SER ASP VAL SEQRES 1 E 140 PRO MET VAL SER ALA ILE VAL LEU TYR VAL LEU LEU ALA SEQRES 2 E 140 ALA ALA ALA HIS SER ALA PHE ALA MET ASP VAL GLN LEU SEQRES 3 E 140 GLN GLU SER GLY PRO GLY LEU VAL LYS PRO SER GLN SER SEQRES 4 E 140 LEU SER LEU THR CYS THR VAL THR GLY TYR SER ILE THR SEQRES 5 E 140 SER ASP TYR ALA TRP ASN TRP ILE ARG GLN PHE PRO GLY SEQRES 6 E 140 ASN LYS LEU GLU TRP MET GLY TYR ILE SER TYR SER GLY SEQRES 7 E 140 SER THR GLY TYR ASN PRO SER LEU LYS SER ARG ILE SER SEQRES 8 E 140 ILE THR ARG ASP THR SER LYS ASN GLN PHE PHE LEU GLN SEQRES 9 E 140 LEU ASN SER VAL THR THR GLU ASP THR ALA THR TYR TYR SEQRES 10 E 140 CYS ALA ARG LEU TYR TYR GLY PHE TYR GLY MET ASP TYR SEQRES 11 E 140 TRP GLY GLN GLY THR SER VAL THR VAL SER SEQRES 1 F 131 MET VAL SER ALA ILE VAL LEU TYR VAL LEU LEU ALA ALA SEQRES 2 F 131 ALA ALA HIS SER ALA PHE ALA MET ILE VAL LEU THR GLN SEQRES 3 F 131 SER PRO ALA SER LEU ALA VAL SER LEU GLY GLN ARG ALA SEQRES 4 F 131 THR ILE SER CYS LYS ALA SER GLN SER VAL ASP TYR ASP SEQRES 5 F 131 GLY ASN SER TYR MET ASN TRP TYR GLN GLN LYS PRO GLY SEQRES 6 F 131 GLN PRO PRO LYS LEU LEU ILE TYR ALA ALA SER ASN LEU SEQRES 7 F 131 GLU SER GLY ILE PRO ALA ARG PHE SER GLY SER GLY SER SEQRES 8 F 131 GLY THR ASP PHE THR LEU ASN ILE HIS PRO VAL GLU GLU SEQRES 9 F 131 GLU ASP ALA ALA THR TYR TYR CYS GLN GLN GLY ASN GLU SEQRES 10 F 131 ASP PRO PRO THR PHE GLY GLY GLY THR LYS LEU GLU ILE SEQRES 11 F 131 LYS SEQRES 1 G 227 GLN VAL THR LEU LYS GLU SER GLY PRO GLY ILE LEU GLN SEQRES 2 G 227 PRO SER GLN THR LEU SER LEU THR CYS SER PHE SER GLY SEQRES 3 G 227 ALA ALA ALA ALA ALA ALA GLY VAL GLY VAL GLY TRP ILE SEQRES 4 G 227 ARG GLN PRO SER GLY LYS GLY LEU GLU TRP LEU ALA HIS SEQRES 5 G 227 ILE ALA ALA ALA ALA ALA LYS ARG TYR ASN PRO ALA LEU SEQRES 6 G 227 LYS SER ARG LEU THR ILE SER LYS ASP THR SER SER SER SEQRES 7 G 227 GLN VAL PHE LEU LYS ILE ALA SER VAL ALA THR ALA ASP SEQRES 8 G 227 THR ALA THR TYR TYR CYS THR ARG ALA ALA ALA ALA ALA SEQRES 9 G 227 ALA PRO TYR TRP GLY GLN GLY THR LEU VAL THR VAL SER SEQRES 10 G 227 ALA LYS ARG ALA ASP ALA ARG THR VAL ALA ALA PRO SER SEQRES 11 G 227 VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER SEQRES 12 G 227 GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR SEQRES 13 G 227 PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA SEQRES 14 G 227 LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN SEQRES 15 G 227 ASP SER LYS ASP SER THR TYR SER LEU SER SER THR LEU SEQRES 16 G 227 THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR SEQRES 17 G 227 ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL SEQRES 18 G 227 THR LYS SER PHE ASN ARG SEQRES 1 H 212 ASP ILE GLN MET THR GLN SER PRO ALA SER LEU SER VAL SEQRES 2 H 212 SER VAL GLY GLU THR VAL THR ILE THR CYS ARG ALA ALA SEQRES 3 H 212 ALA ALA ALA ALA ALA ALA LEU ALA TRP TYR GLN GLN LYS SEQRES 4 H 212 GLN GLY LYS SER PRO GLN LEU LEU VAL ALA ALA ALA ALA SEQRES 5 H 212 ALA ALA ALA ASP GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 H 212 GLY SER GLY THR GLN TYR SER LEU LYS ILE ASN SER LEU SEQRES 7 H 212 GLN SER GLU ASP PHE GLY SER TYR TYR CYS GLN ALA ALA SEQRES 8 H 212 ALA ALA ALA PRO TRP THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 H 212 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 H 212 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 H 212 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 H 212 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 H 212 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 H 212 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 H 212 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 H 212 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 H 212 PHE ASN ARG GLY SEQRES 1 I 140 PRO MET VAL SER ALA ILE VAL LEU TYR VAL LEU LEU ALA SEQRES 2 I 140 ALA ALA ALA HIS SER ALA PHE ALA MET ASP VAL GLN LEU SEQRES 3 I 140 GLN GLU SER GLY PRO GLY LEU VAL LYS PRO SER GLN SER SEQRES 4 I 140 LEU SER LEU THR CYS THR VAL THR GLY TYR SER ILE THR SEQRES 5 I 140 SER ASP TYR ALA TRP ASN TRP ILE ARG GLN PHE PRO GLY SEQRES 6 I 140 ASN LYS LEU GLU TRP MET GLY TYR ILE SER TYR SER GLY SEQRES 7 I 140 SER THR GLY TYR ASN PRO SER LEU LYS SER ARG ILE SER SEQRES 8 I 140 ILE THR ARG ASP THR SER LYS ASN GLN PHE PHE LEU GLN SEQRES 9 I 140 LEU ASN SER VAL THR THR GLU ASP THR ALA THR TYR TYR SEQRES 10 I 140 CYS ALA ARG LEU TYR TYR GLY PHE TYR GLY MET ASP TYR SEQRES 11 I 140 TRP GLY GLN GLY THR SER VAL THR VAL SER SEQRES 1 J 131 MET VAL SER ALA ILE VAL LEU TYR VAL LEU LEU ALA ALA SEQRES 2 J 131 ALA ALA HIS SER ALA PHE ALA MET ILE VAL LEU THR GLN SEQRES 3 J 131 SER PRO ALA SER LEU ALA VAL SER LEU GLY GLN ARG ALA SEQRES 4 J 131 THR ILE SER CYS LYS ALA SER GLN SER VAL ASP TYR ASP SEQRES 5 J 131 GLY ASN SER TYR MET ASN TRP TYR GLN GLN LYS PRO GLY SEQRES 6 J 131 GLN PRO PRO LYS LEU LEU ILE TYR ALA ALA SER ASN LEU SEQRES 7 J 131 GLU SER GLY ILE PRO ALA ARG PHE SER GLY SER GLY SER SEQRES 8 J 131 GLY THR ASP PHE THR LEU ASN ILE HIS PRO VAL GLU GLU SEQRES 9 J 131 GLU ASP ALA ALA THR TYR TYR CYS GLN GLN GLY ASN GLU SEQRES 10 J 131 ASP PRO PRO THR PHE GLY GLY GLY THR LYS LEU GLU ILE SEQRES 11 J 131 LYS SEQRES 1 K 248 MET VAL SER ALA ILE VAL LEU TYR VAL LEU LEU ALA ALA SEQRES 2 K 248 ALA ALA HIS SER ALA PHE ALA ASP VAL LYS LEU GLN GLU SEQRES 3 K 248 SER GLY GLY GLY LEU VAL GLN PRO GLY GLY SER LEU LYS SEQRES 4 K 248 LEU SER CYS ALA ALA SER GLY PHE THR PHE SER SER TYR SEQRES 5 K 248 THR MET SER TRP VAL ARG GLN THR PRO GLU LYS ARG LEU SEQRES 6 K 248 GLU TRP VAL ALA TYR ILE SER ASN GLY GLY GLY GLY THR SEQRES 7 K 248 TYR TYR PRO ASP THR VAL LYS GLY ARG PHE THR ILE SER SEQRES 8 K 248 ARG ASP ASN ALA LYS ASN THR LEU TYR LEU GLN MET ASN SEQRES 9 K 248 SER LEU LYS GLU ASP THR ALA MET TYR TYR CYS ALA ARG SEQRES 10 K 248 PRO SER ARG GLY GLY SER SER TYR TRP TYR PHE ASP VAL SEQRES 11 K 248 TRP GLY ALA GLY THR THR VAL THR VAL SER SER ALA LYS SEQRES 12 K 248 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 13 K 248 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 14 K 248 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 15 K 248 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 16 K 248 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 17 K 248 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 18 K 248 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 19 K 248 VAL ASP LYS ARG HIS HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 20 K 248 HIS SEQRES 1 L 265 MET VAL SER ALA ILE VAL LEU TYR VAL LEU LEU ALA ALA SEQRES 2 L 265 ALA ALA HIS SER ALA PHE ALA ASP ILE GLN MET THR GLN SEQRES 3 L 265 SER PRO SER SER LEU SER ALA SER LEU GLY GLY LYS VAL SEQRES 4 L 265 THR ILE THR CYS LYS ALA SER GLN ASP ILE ASN LYS TYR SEQRES 5 L 265 ILE ALA TRP TYR GLN HIS LYS PRO GLY LYS GLY PRO ARG SEQRES 6 L 265 LEU LEU ILE HIS TYR THR SER SER LEU GLN PRO GLY ILE SEQRES 7 L 265 PRO SER ARG PHE SER GLY SER GLY SER GLY ARG ASP TYR SEQRES 8 L 265 SER PHE SER ILE SER ASN LEU GLU PRO GLU ASP ILE ALA SEQRES 9 L 265 THR TYR TYR CYS LEU GLN TYR ASP ASN LEU TYR THR PHE SEQRES 10 L 265 GLY GLY GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA SEQRES 11 L 265 ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN SEQRES 12 L 265 LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN SEQRES 13 L 265 ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL SEQRES 14 L 265 ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL SEQRES 15 L 265 THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SEQRES 16 L 265 SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS SEQRES 17 L 265 LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SEQRES 18 L 265 SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS GLY SEQRES 19 L 265 SER GLY SER TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SEQRES 20 L 265 GLY SER GLY GLY GLY SER GLY GLY SER ALA TRP SER HIS SEQRES 21 L 265 PRO GLN PHE GLU LYS HET NAG M 1 14 HET NAG M 2 14 HET MAN M 3 11 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET MAN O 3 11 HET NAG A1001 14 HET NAG A1002 14 HET NAG A1003 14 HET NAG A1004 14 HET NAG A1005 14 HET NAG A1006 14 HET NAG A1007 14 HET NAG B1501 14 HET NAG B1502 14 HET NAG B1503 14 HET 7RC B1504 16 HET NAG C1001 14 HET NAG C1002 14 HET NAG C1003 14 HET NAG C1004 14 HET NAG C1005 14 HET NAG C1006 14 HET NAG C1007 14 HET NAG D1501 14 HET NAG D1502 14 HET NAG D1503 14 HET 7RC D1504 16 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETNAM 7RC (2R)-4-(3-PHOSPHONOPROPYL)PIPERAZINE-2-CARBOXYLIC ACID HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 13 NAG 26(C8 H15 N O6) FORMUL 13 MAN 2(C6 H12 O6) FORMUL 26 7RC 2(C8 H17 N2 O5 P) HELIX 1 AA1 THR A 35 GLY A 54 1 20 HELIX 2 AA2 ASN A 70 LEU A 82 1 13 HELIX 3 AA3 ILE A 83 SER A 85 5 3 HELIX 4 AA4 THR A 103 PHE A 113 1 11 HELIX 5 AA5 MET A 125 ASP A 130 5 6 HELIX 6 AA6 PRO A 143 TYR A 158 1 16 HELIX 7 AA7 ASP A 170 ARG A 187 1 18 HELIX 8 AA8 VAL A 204 LEU A 214 1 11 HELIX 9 AA9 SER A 224 LEU A 238 1 15 HELIX 10 AB1 GLU A 251 ILE A 254 5 4 HELIX 11 AB2 SER A 255 ARG A 260 5 6 HELIX 12 AB3 ASN A 276 GLU A 297 1 22 HELIX 13 AB4 LYS A 316 SER A 327 1 12 HELIX 14 AB5 GLY A 457 ASN A 471 1 15 HELIX 15 AB6 ASN A 499 SER A 507 1 9 HELIX 16 AB7 ASN A 520 GLN A 525 1 6 HELIX 17 AB8 GLN A 559 LEU A 580 1 22 HELIX 18 AB9 ASP A 581 SER A 584 5 4 HELIX 19 AC1 LEU A 603 LEU A 614 1 12 HELIX 20 AC2 SER A 626 ASP A 658 1 33 HELIX 21 AC3 ASP A 669 ASN A 674 1 6 HELIX 22 AC4 SER A 687 GLN A 696 1 10 HELIX 23 AC5 LEU A 699 LYS A 708 1 10 HELIX 24 AC6 SER A 713 ASP A 723 1 11 HELIX 25 AC7 SER A 733 CYS A 744 1 12 HELIX 26 AC8 TRP A 768 ASN A 782 1 15 HELIX 27 AC9 GLY A 783 VAL A 793 1 11 HELIX 28 AD1 MET A 813 ARG A 839 1 27 HELIX 29 AD2 THR B 47 LEU B 54 1 8 HELIX 30 AD3 GLY B 56 THR B 61 1 6 HELIX 31 AD4 ASP B 78 ARG B 94 1 17 HELIX 32 AD5 GLU B 107 PHE B 121 1 15 HELIX 33 AD6 HIS B 128 SER B 132 5 5 HELIX 34 AD7 SER B 150 TYR B 165 1 16 HELIX 35 AD8 GLY B 179 SER B 194 1 16 HELIX 36 AD9 GLU B 211 LYS B 221 1 11 HELIX 37 AE1 SER B 232 LEU B 246 1 15 HELIX 38 AE2 PRO B 258 GLY B 263 1 6 HELIX 39 AE3 SER B 287 SER B 311 1 25 HELIX 40 AE4 PRO B 330 MET B 338 1 9 HELIX 41 AE5 PHE B 459 LYS B 472 1 14 HELIX 42 AE6 ASN B 494 TYR B 502 1 9 HELIX 43 AE7 ASN B 515 VAL B 522 1 8 HELIX 44 AE8 SER B 547 GLU B 551 5 5 HELIX 45 AE9 SER B 554 PHE B 579 1 26 HELIX 46 AF1 THR B 600 ASN B 614 1 15 HELIX 47 AF2 THR B 626 MET B 653 1 28 HELIX 48 AF3 ASP B 667 ARG B 672 1 6 HELIX 49 AF4 PRO B 673 TYR B 676 5 4 HELIX 50 AF5 GLY B 688 TYR B 698 1 11 HELIX 51 AF6 TYR B 698 THR B 706 1 9 HELIX 52 AF7 GLY B 712 THR B 722 1 11 HELIX 53 AF8 ALA B 732 ASP B 742 1 11 HELIX 54 AF9 GLU B 743 CYS B 745 5 3 HELIX 55 AG1 TRP B 771 GLY B 786 1 16 HELIX 56 AG2 GLY B 786 LEU B 796 1 11 HELIX 57 AG3 MET B 817 PHE B 841 1 25 HELIX 58 AG4 THR C 35 GLY C 54 1 20 HELIX 59 AG5 ALA C 71 ASP C 81 1 11 HELIX 60 AG6 THR C 103 TYR C 114 1 12 HELIX 61 AG7 MET C 125 SER C 129 5 5 HELIX 62 AG8 SER C 145 ASN C 159 1 15 HELIX 63 AG9 ASP C 170 GLU C 186 1 17 HELIX 64 AH1 VAL C 204 GLU C 213 1 10 HELIX 65 AH2 SER C 224 LEU C 238 1 15 HELIX 66 AH3 GLU C 251 SER C 255 5 5 HELIX 67 AH4 GLU C 277 GLU C 297 1 21 HELIX 68 AH5 THR C 317 SER C 328 1 12 HELIX 69 AH6 TRP C 381 GLU C 385 5 5 HELIX 70 AH7 GLY C 457 MET C 470 1 14 HELIX 71 AH8 GLY C 500 SER C 507 1 8 HELIX 72 AH9 ASN C 520 ILE C 527 1 8 HELIX 73 AI1 GLN C 559 LEU C 580 1 22 HELIX 74 AI2 LEU C 603 ASN C 616 1 14 HELIX 75 AI3 PHE C 627 LEU C 657 1 31 HELIX 76 AI4 ASP C 669 ASN C 674 1 6 HELIX 77 AI5 SER C 687 GLN C 696 1 10 HELIX 78 AI6 LEU C 699 GLU C 707 1 9 HELIX 79 AI7 SER C 713 ASP C 723 1 11 HELIX 80 AI8 SER C 733 CYS C 744 1 12 HELIX 81 AI9 TRP C 768 ASN C 782 1 15 HELIX 82 AJ1 GLY C 783 VAL C 793 1 11 HELIX 83 AJ2 PHE C 810 ILE C 828 1 19 HELIX 84 AJ3 PHE C 829 LYS C 838 1 10 HELIX 85 AJ4 GLU D 47 ASP D 52 1 6 HELIX 86 AJ5 ASP D 77 ARG D 92 1 16 HELIX 87 AJ6 GLU D 106 GLN D 118 1 13 HELIX 88 AJ7 SER D 149 TYR D 164 1 16 HELIX 89 AJ8 TYR D 179 ASN D 192 1 14 HELIX 90 AJ9 ASP D 211 LYS D 221 1 11 HELIX 91 AK1 THR D 233 GLY D 248 1 16 HELIX 92 AK2 PRO D 259 GLY D 264 1 6 HELIX 93 AK3 GLY D 288 HIS D 311 1 24 HELIX 94 AK4 ARG D 328 ASN D 341 1 14 HELIX 95 AK5 GLY D 459 LYS D 473 1 15 HELIX 96 AK6 ASN D 495 MET D 503 1 9 HELIX 97 AK7 ASN D 516 GLU D 521 1 6 HELIX 98 AK8 SER D 555 GLU D 578 1 24 HELIX 99 AK9 LYS D 604 ASN D 615 1 12 HELIX 100 AL1 SER D 628 PHE D 653 1 26 HELIX 101 AL2 ASP D 668 ARG D 673 1 6 HELIX 102 AL3 GLY D 689 TYR D 699 1 11 HELIX 103 AL4 TYR D 699 GLY D 707 1 9 HELIX 104 AL5 GLY D 713 THR D 723 1 11 HELIX 105 AL6 ALA D 733 ARG D 742 1 10 HELIX 106 AL7 GLY D 771 GLY D 787 1 17 HELIX 107 AL8 GLY D 787 LEU D 797 1 11 HELIX 108 AL9 MET D 818 PHE D 842 1 25 HELIX 109 AM1 PRO G 63 LYS G 66 5 4 HELIX 110 AM2 ALA G 88 THR G 92 5 5 HELIX 111 AM3 LYS G 199 LYS G 204 1 6 HELIX 112 AM4 SER H 121 GLY H 128 1 8 HELIX 113 AM5 LYS H 183 HIS H 189 1 7 HELIX 114 AM6 ASN I 81 LYS I 85 5 5 HELIX 115 AM7 TYR I 120 TYR I 124 5 5 SHEET 1 AA1 5 GLN A 59 THR A 66 0 SHEET 2 AA1 5 ILE A 26 LEU A 33 1 N VAL A 27 O ASN A 61 SHEET 3 AA1 5 VAL A 87 VAL A 92 1 O TYR A 88 N ASN A 28 SHEET 4 AA1 5 VAL A 118 GLY A 120 1 O LEU A 119 N ILE A 90 SHEET 5 AA1 5 PHE A 137 ARG A 139 1 O LEU A 138 N GLY A 120 SHEET 1 AA2 4 LYS A 193 PHE A 197 0 SHEET 2 AA2 4 ILE A 164 SER A 168 1 N VAL A 167 O LEU A 195 SHEET 3 AA2 4 VAL A 218 SER A 222 1 O ILE A 220 N LEU A 166 SHEET 4 AA2 4 VAL A 246 VAL A 249 1 O VAL A 246 N ILE A 219 SHEET 1 AA3 4 ILE A 267 LEU A 271 0 SHEET 2 AA3 4 TYR A 351 LEU A 356 -1 O SER A 352 N GLN A 270 SHEET 3 AA3 4 LEU A 361 TYR A 367 -1 O VAL A 362 N ASN A 355 SHEET 4 AA3 4 VAL A 372 PRO A 374 -1 O ILE A 373 N ILE A 366 SHEET 1 AA4 2 GLU A 339 PHE A 340 0 SHEET 2 AA4 2 ARG A 346 LYS A 347 -1 O LYS A 347 N GLU A 339 SHEET 1 AA5 5 GLU A 475 LEU A 478 0 SHEET 2 AA5 5 LYS A 399 THR A 402 1 N ILE A 400 O GLU A 475 SHEET 3 AA5 5 MET A 512 ILE A 513 1 N MET A 512 O LYS A 399 SHEET 4 AA5 5 GLY A 761 MET A 762 -1 O GLY A 761 N ILE A 513 SHEET 5 AA5 5 GLU A 528 PHE A 529 -1 N GLU A 528 O MET A 762 SHEET 1 AA6 3 TYR A 410 PRO A 413 0 SHEET 2 AA6 3 VAL A 451 TYR A 456 -1 O CYS A 454 N LYS A 412 SHEET 3 AA6 3 VAL A 434 GLY A 438 -1 N CYS A 436 O GLN A 453 SHEET 1 AA7 2 GLN A 487 VAL A 490 0 SHEET 2 AA7 2 LYS A 495 TRP A 498 -1 O GLU A 497 N GLU A 488 SHEET 1 AA8 4 TYR A 681 ALA A 682 0 SHEET 2 AA8 4 ALA A 728 ASP A 732 1 O ILE A 730 N ALA A 682 SHEET 3 AA8 4 TYR A 535 LYS A 543 -1 N THR A 539 O TRP A 731 SHEET 4 AA8 4 LEU A 746 GLY A 757 -1 O SER A 756 N GLN A 536 SHEET 1 AA9 5 VAL B 69 MET B 74 0 SHEET 2 AA9 5 ILE B 36 GLY B 41 1 N VAL B 38 O LEU B 72 SHEET 3 AA9 5 GLY B 97 ASP B 102 1 O GLY B 97 N ALA B 37 SHEET 4 AA9 5 ILE B 124 GLY B 126 1 O LEU B 125 N PHE B 100 SHEET 5 AA9 5 PHE B 144 PHE B 145 1 O PHE B 145 N ILE B 124 SHEET 1 AB1 8 ASP B 199 THR B 205 0 SHEET 2 AB1 8 VAL B 169 THR B 174 1 N THR B 174 O ILE B 204 SHEET 3 AB1 8 VAL B 226 TYR B 230 1 O LEU B 228 N SER B 171 SHEET 4 AB1 8 PHE B 254 VAL B 257 1 O ILE B 256 N LEU B 229 SHEET 5 AB1 8 ILE B 277 SER B 280 1 O ILE B 277 N TRP B 255 SHEET 6 AB1 8 LEU B 361 LEU B 366 -1 O VAL B 362 N SER B 280 SHEET 7 AB1 8 TRP B 372 GLU B 379 -1 O GLY B 376 N VAL B 363 SHEET 8 AB1 8 THR B 382 LEU B 385 -1 O SER B 384 N LYS B 377 SHEET 1 AB2 2 HIS B 405 LEU B 406 0 SHEET 2 AB2 2 THR B 474 TYR B 475 1 O THR B 474 N LEU B 406 SHEET 1 AB3 2 VAL B 409 THR B 410 0 SHEET 2 AB3 2 TYR B 478 LEU B 479 1 O TYR B 478 N THR B 410 SHEET 1 AB4 3 ILE B 418 GLU B 420 0 SHEET 2 AB4 3 GLY B 449 LYS B 457 -1 O LYS B 457 N ILE B 418 SHEET 3 AB4 3 VAL B 434 LYS B 441 -1 N VAL B 434 O CYS B 456 SHEET 1 AB5 4 PHE B 682 THR B 684 0 SHEET 2 AB5 4 ALA B 727 ASP B 731 1 O ILE B 729 N GLY B 683 SHEET 3 AB5 4 GLU B 530 SER B 538 -1 N SER B 534 O TYR B 730 SHEET 4 AB5 4 LEU B 747 THR B 749 -1 O VAL B 748 N VAL B 537 SHEET 1 AB6 4 PHE B 682 THR B 684 0 SHEET 2 AB6 4 ALA B 727 ASP B 731 1 O ILE B 729 N GLY B 683 SHEET 3 AB6 4 GLU B 530 SER B 538 -1 N SER B 534 O TYR B 730 SHEET 4 AB6 4 PHE B 756 GLY B 760 -1 O THR B 759 N THR B 531 SHEET 1 AB7 5 GLN C 59 ALA C 62 0 SHEET 2 AB7 5 ILE C 26 VAL C 32 1 N VAL C 27 O GLN C 59 SHEET 3 AB7 5 ILE C 90 VAL C 92 1 O LEU C 91 N GLY C 30 SHEET 4 AB7 5 VAL C 118 GLY C 120 1 O LEU C 119 N VAL C 92 SHEET 5 AB7 5 PHE C 137 ARG C 139 1 O LEU C 138 N GLY C 120 SHEET 1 AB8 4 LYS C 193 PHE C 197 0 SHEET 2 AB8 4 ILE C 164 SER C 168 1 N LEU C 165 O LYS C 193 SHEET 3 AB8 4 VAL C 218 ILE C 220 1 O VAL C 218 N ILE C 164 SHEET 4 AB8 4 VAL C 246 LEU C 248 1 O VAL C 246 N ILE C 219 SHEET 1 AB9 4 ILE C 267 GLY C 268 0 SHEET 2 AB9 4 ILE C 353 LEU C 356 -1 O MET C 354 N GLY C 268 SHEET 3 AB9 4 LEU C 361 TYR C 367 -1 O GLY C 365 N ILE C 353 SHEET 4 AB9 4 VAL C 372 PRO C 374 -1 O ILE C 373 N ILE C 366 SHEET 1 AC1 8 TYR C 410 PRO C 413 0 SHEET 2 AC1 8 THR C 450 TYR C 456 -1 O CYS C 454 N LYS C 412 SHEET 3 AC1 8 VAL C 434 PRO C 439 -1 N VAL C 434 O CYS C 455 SHEET 4 AC1 8 THR C 473 LEU C 478 1 O VAL C 476 N THR C 437 SHEET 5 AC1 8 ARG C 397 THR C 402 1 N ILE C 400 O GLU C 475 SHEET 6 AC1 8 MET C 512 ILE C 513 1 N MET C 512 O LYS C 399 SHEET 7 AC1 8 GLY C 761 MET C 762 -1 O GLY C 761 N ILE C 513 SHEET 8 AC1 8 GLU C 528 PHE C 529 -1 N GLU C 528 O MET C 762 SHEET 1 AC2 2 GLN C 487 ARG C 489 0 SHEET 2 AC2 2 LYS C 496 TRP C 498 -1 O GLU C 497 N GLU C 488 SHEET 1 AC3 4 TYR C 681 ALA C 682 0 SHEET 2 AC3 4 ALA C 728 ASP C 732 1 O ALA C 728 N ALA C 682 SHEET 3 AC3 4 LYS C 534 LYS C 543 -1 N THR C 539 O TRP C 731 SHEET 4 AC3 4 LEU C 746 PHE C 758 -1 O VAL C 747 N VAL C 542 SHEET 1 AC4 5 ARG D 67 MET D 73 0 SHEET 2 AC4 5 GLY D 36 VAL D 42 1 N ILE D 37 O ARG D 67 SHEET 3 AC4 5 GLY D 96 PHE D 99 1 O VAL D 98 N ALA D 38 SHEET 4 AC4 5 ILE D 123 GLY D 125 1 O LEU D 124 N VAL D 97 SHEET 5 AC4 5 PHE D 143 GLN D 145 1 O PHE D 144 N ILE D 123 SHEET 1 AC5 8 GLU D 198 LEU D 205 0 SHEET 2 AC5 8 ILE D 168 THR D 174 1 N PHE D 169 O GLU D 200 SHEET 3 AC5 8 ILE D 227 TYR D 231 1 O LEU D 229 N SER D 170 SHEET 4 AC5 8 THR D 255 VAL D 258 1 O ILE D 257 N LEU D 230 SHEET 5 AC5 8 ILE D 278 SER D 281 1 O VAL D 280 N VAL D 258 SHEET 6 AC5 8 LEU D 362 LEU D 367 -1 O VAL D 363 N SER D 281 SHEET 7 AC5 8 TRP D 373 LYS D 380 -1 O VAL D 376 N ILE D 364 SHEET 8 AC5 8 SER D 383 MET D 386 -1 O GLN D 385 N LYS D 378 SHEET 1 AC6 2 THR D 343 PHE D 344 0 SHEET 2 AC6 2 ARG D 347 ASN D 348 -1 O ARG D 347 N PHE D 344 SHEET 1 AC710 VAL D 419 SER D 421 0 SHEET 2 AC710 TYR D 452 CYS D 457 -1 O CYS D 456 N GLU D 420 SHEET 3 AC710 VAL D 434 ARG D 439 -1 N CYS D 436 O LYS D 455 SHEET 4 AC710 THR D 475 LEU D 480 1 O LEU D 478 N GLN D 437 SHEET 5 AC710 HIS D 405 THR D 410 1 N ILE D 408 O ASP D 477 SHEET 6 AC710 MET D 508 THR D 514 1 O MET D 508 N VAL D 409 SHEET 7 AC710 PHE D 757 ILE D 766 -1 O GLY D 763 N LEU D 513 SHEET 8 AC710 ILE D 530 SER D 539 -1 N ILE D 530 O TYR D 762 SHEET 9 AC710 ALA D 728 ASP D 732 -1 O TYR D 731 N SER D 535 SHEET 10 AC710 PHE D 683 THR D 685 1 N GLY D 684 O ILE D 730 SHEET 1 AC8 4 ASP D 524 PHE D 525 0 SHEET 2 AC8 4 PHE D 757 ILE D 766 -1 O ILE D 766 N ASP D 524 SHEET 3 AC8 4 ILE D 530 SER D 539 -1 N ILE D 530 O TYR D 762 SHEET 4 AC8 4 LEU D 748 VAL D 749 -1 O VAL D 749 N VAL D 538 SHEET 1 AC9 4 GLN E 23 SER E 27 0 SHEET 2 AC9 4 SER E 37 THR E 45 -1 O THR E 45 N GLN E 23 SHEET 3 AC9 4 GLN E 98 ASN E 104 -1 O LEU E 103 N LEU E 38 SHEET 4 AC9 4 SER E 89 ASP E 93 -1 N SER E 89 O GLN E 102 SHEET 1 AD1 5 THR E 78 TYR E 80 0 SHEET 2 AD1 5 LYS E 65 ILE E 72 -1 N TYR E 71 O GLY E 79 SHEET 3 AD1 5 ALA E 54 PHE E 61 -1 N TRP E 57 O GLY E 70 SHEET 4 AD1 5 ALA E 112 LEU E 119 -1 O ALA E 117 N ASN E 56 SHEET 5 AD1 5 THR E 133 VAL E 135 -1 O VAL E 135 N ALA E 112 SHEET 1 AD2 4 LEU F 23 SER F 26 0 SHEET 2 AD2 4 ALA F 38 ALA F 44 -1 O SER F 41 N SER F 26 SHEET 3 AD2 4 ASP F 93 ILE F 98 -1 O LEU F 96 N ILE F 40 SHEET 4 AD2 4 PHE F 85 SER F 90 -1 N SER F 88 O THR F 95 SHEET 1 AD3 3 LYS F 68 TYR F 72 0 SHEET 2 AD3 3 MET F 56 GLN F 61 -1 N TRP F 58 O ILE F 71 SHEET 3 AD3 3 THR F 108 GLN F 113 -1 O THR F 108 N GLN F 61 SHEET 1 AD4 4 LEU G 4 SER G 7 0 SHEET 2 AD4 4 THR G 21 PHE G 24 -1 O SER G 23 N LYS G 5 SHEET 3 AD4 4 GLN G 79 ILE G 84 -1 O VAL G 80 N CYS G 22 SHEET 4 AD4 4 LEU G 69 ASP G 74 -1 N ASP G 74 O GLN G 79 SHEET 1 AD5 6 ILE G 11 LEU G 12 0 SHEET 2 AD5 6 THR G 112 VAL G 116 1 O THR G 115 N LEU G 12 SHEET 3 AD5 6 ALA G 93 ALA G 100 -1 N TYR G 95 O THR G 112 SHEET 4 AD5 6 GLY G 35 GLN G 41 -1 N GLY G 35 O ALA G 100 SHEET 5 AD5 6 GLU G 48 ILE G 53 -1 O ALA G 51 N TRP G 38 SHEET 6 AD5 6 LYS G 59 TYR G 61 -1 O ARG G 60 N HIS G 52 SHEET 1 AD6 4 ILE G 11 LEU G 12 0 SHEET 2 AD6 4 THR G 112 VAL G 116 1 O THR G 115 N LEU G 12 SHEET 3 AD6 4 ALA G 93 ALA G 100 -1 N TYR G 95 O THR G 112 SHEET 4 AD6 4 TYR G 107 TRP G 108 -1 O TYR G 107 N ARG G 99 SHEET 1 AD7 3 SER G 130 PHE G 132 0 SHEET 2 AD7 3 LEU G 151 ASN G 153 -1 O LEU G 151 N PHE G 132 SHEET 3 AD7 3 SER G 190 LEU G 191 -1 O LEU G 191 N LEU G 152 SHEET 1 AD8 2 CYS G 210 HIS G 214 0 SHEET 2 AD8 2 SER G 219 LYS G 223 -1 O SER G 219 N HIS G 214 SHEET 1 AD9 4 MET H 4 THR H 5 0 SHEET 2 AD9 4 VAL H 19 ALA H 25 -1 O ARG H 24 N THR H 5 SHEET 3 AD9 4 GLN H 70 ILE H 75 -1 O ILE H 75 N VAL H 19 SHEET 4 AD9 4 PHE H 62 SER H 67 -1 N SER H 63 O LYS H 74 SHEET 1 AE1 4 ALA H 53 ALA H 54 0 SHEET 2 AE1 4 GLN H 45 ALA H 49 -1 N ALA H 49 O ALA H 53 SHEET 3 AE1 4 LEU H 33 GLN H 38 -1 N GLN H 37 O GLN H 45 SHEET 4 AE1 4 SER H 85 ALA H 90 -1 O TYR H 87 N TYR H 36 SHEET 1 AE2 4 SER H 114 PHE H 118 0 SHEET 2 AE2 4 THR H 129 PHE H 139 -1 O ASN H 137 N SER H 114 SHEET 3 AE2 4 TYR H 173 SER H 182 -1 O SER H 177 N CYS H 134 SHEET 4 AE2 4 SER H 159 GLN H 160 -1 N GLN H 160 O THR H 178 SHEET 1 AE3 3 LYS H 145 VAL H 150 0 SHEET 2 AE3 3 TYR H 192 THR H 197 -1 O GLU H 195 N GLN H 147 SHEET 3 AE3 3 LYS H 207 SER H 208 -1 O LYS H 207 N CYS H 194 SHEET 1 AE4 4 GLN I 23 SER I 27 0 SHEET 2 AE4 4 LEU I 38 THR I 45 -1 O THR I 45 N GLN I 23 SHEET 3 AE4 4 GLN I 98 LEU I 103 -1 O LEU I 101 N LEU I 40 SHEET 4 AE4 4 SER I 89 ASP I 93 -1 N THR I 91 O PHE I 100 SHEET 1 AE5 5 THR I 78 GLY I 79 0 SHEET 2 AE5 5 LEU I 66 ILE I 72 -1 N TYR I 71 O GLY I 79 SHEET 3 AE5 5 ALA I 54 GLN I 60 -1 N TRP I 57 O GLY I 70 SHEET 4 AE5 5 ALA I 112 LEU I 119 -1 O ALA I 117 N ASN I 56 SHEET 5 AE5 5 THR I 133 VAL I 135 -1 O THR I 133 N TYR I 114 SHEET 1 AE6 4 LEU J 23 SER J 26 0 SHEET 2 AE6 4 ALA J 38 ALA J 44 -1 O SER J 41 N SER J 26 SHEET 3 AE6 4 ASP J 93 ILE J 98 -1 O ILE J 98 N ALA J 38 SHEET 4 AE6 4 PHE J 85 SER J 90 -1 N SER J 90 O ASP J 93 SHEET 1 AE7 2 ASP J 49 TYR J 50 0 SHEET 2 AE7 2 ASN J 53 SER J 54 -1 O ASN J 53 N TYR J 50 SHEET 1 AE8 3 LYS J 68 ILE J 71 0 SHEET 2 AE8 3 MET J 56 GLN J 60 -1 N GLN J 60 O LYS J 68 SHEET 3 AE8 3 CYS J 111 GLN J 113 -1 O GLN J 112 N ASN J 57 SHEET 1 AE9 4 LYS K 23 SER K 27 0 SHEET 2 AE9 4 LEU K 38 SER K 45 -1 O SER K 41 N SER K 27 SHEET 3 AE9 4 THR K 98 MET K 103 -1 O LEU K 101 N LEU K 40 SHEET 4 AE9 4 ILE K 90 ASP K 93 -1 N ASP K 93 O THR K 98 SHEET 1 AF1 2 VAL K 57 GLN K 59 0 SHEET 2 AF1 2 LEU K 65 TRP K 67 -1 O GLU K 66 N ARG K 58 SHEET 1 AF2 2 MET K 113 TYR K 114 0 SHEET 2 AF2 2 THR K 136 THR K 137 -1 O THR K 136 N TYR K 114 SHEET 1 AF3 2 ALA K 117 ARG K 118 0 SHEET 2 AF3 2 VAL K 131 TRP K 132 -1 O VAL K 131 N ARG K 118 SHEET 1 AF4 3 LYS L 38 LYS L 44 0 SHEET 2 AF4 3 ASP L 90 SER L 96 -1 O ILE L 95 N VAL L 39 SHEET 3 AF4 3 PHE L 82 SER L 87 -1 N SER L 85 O SER L 92 SHEET 1 AF5 4 ARG L 65 LEU L 66 0 SHEET 2 AF5 4 TRP L 55 GLN L 57 -1 N GLN L 57 O ARG L 65 SHEET 3 AF5 4 THR L 105 CYS L 108 -1 O TYR L 107 N TYR L 56 SHEET 4 AF5 4 THR L 121 LYS L 122 -1 O THR L 121 N TYR L 106 SSBOND 1 CYS A 79 CYS A 308 1555 1555 2.03 SSBOND 2 CYS A 420 CYS A 454 1555 1555 2.03 SSBOND 3 CYS A 436 CYS A 455 1555 1555 2.03 SSBOND 4 CYS A 744 CYS A 798 1555 1555 2.03 SSBOND 5 CYS B 87 CYS B 320 1555 1555 2.03 SSBOND 6 CYS B 429 CYS B 455 1555 1555 2.04 SSBOND 7 CYS B 436 CYS B 456 1555 1555 2.04 SSBOND 8 CYS B 745 CYS B 800 1555 1555 2.03 SSBOND 9 CYS C 79 CYS C 308 1555 1555 2.04 SSBOND 10 CYS C 420 CYS C 454 1555 1555 2.03 SSBOND 11 CYS C 436 CYS C 455 1555 1555 2.04 SSBOND 12 CYS C 744 CYS C 798 1555 1555 2.03 SSBOND 13 CYS D 86 CYS D 321 1555 1555 2.03 SSBOND 14 CYS D 429 CYS D 456 1555 1555 2.03 SSBOND 15 CYS D 436 CYS D 457 1555 1555 2.03 SSBOND 16 CYS E 42 CYS E 116 1555 1555 2.03 SSBOND 17 CYS F 42 CYS F 111 1555 1555 2.03 SSBOND 18 CYS G 22 CYS G 97 1555 1555 2.03 SSBOND 19 CYS G 150 CYS G 210 1555 1555 2.03 SSBOND 20 CYS H 23 CYS H 88 1555 1555 2.03 SSBOND 21 CYS H 134 CYS H 194 1555 1555 2.03 SSBOND 22 CYS I 42 CYS I 116 1555 1555 2.04 SSBOND 23 CYS J 42 CYS J 111 1555 1555 2.04 SSBOND 24 CYS K 42 CYS K 116 1555 1555 2.03 SSBOND 25 CYS L 43 CYS L 108 1555 1555 2.03 LINK ND2 ASN A 61 C1 NAG A1001 1555 1555 1.44 LINK ND2 ASN A 203 C1 NAG A1002 1555 1555 1.57 LINK ND2 ASN A 239 C1 NAG A1003 1555 1555 1.44 LINK ND2 ASN A 276 C1 NAG A1004 1555 1555 1.45 LINK ND2 ASN A 300 C1 NAG A1005 1555 1555 1.44 LINK ND2 ASN A 350 C1 NAG A1006 1555 1555 1.44 LINK ND2 ASN A 471 C1 NAG A1007 1555 1555 1.56 LINK ND2 ASN A 771 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN B 340 C1 NAG B1502 1555 1555 1.44 LINK ND2 ASN B 380 C1 NAG B1503 1555 1555 1.45 LINK ND2 ASN B 541 C1 NAG B1501 1555 1555 1.44 LINK ND2 ASN B 687 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN C 61 C1 NAG C1001 1555 1555 1.45 LINK ND2 ASN C 203 C1 NAG C1002 1555 1555 1.44 LINK ND2 ASN C 239 C1 NAG C1003 1555 1555 1.44 LINK ND2 ASN C 276 C1 NAG C1004 1555 1555 1.44 LINK ND2 ASN C 300 C1 NAG C1005 1555 1555 1.45 LINK ND2 ASN C 350 C1 NAG C1006 1555 1555 1.45 LINK ND2 ASN C 471 C1 NAG C1007 1555 1555 1.45 LINK ND2 ASN C 771 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN D 341 C1 NAG D1502 1555 1555 1.44 LINK ND2 ASN D 542 C1 NAG D1501 1555 1555 1.44 LINK ND2 ASN D 688 C1 NAG D1503 1555 1555 1.52 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG M 2 C1 MAN M 3 1555 1555 1.45 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG O 2 C1 MAN O 3 1555 1555 1.44 CISPEP 1 GLU A 406 PRO A 407 0 -4.52 CISPEP 2 ALA B 414 PRO B 415 0 -3.75 CISPEP 3 SER B 677 PRO B 678 0 2.02 CISPEP 4 GLU C 406 PRO C 407 0 -2.42 CISPEP 5 ALA D 414 PRO D 415 0 -4.57 CISPEP 6 SER D 678 PRO D 679 0 0.44 CISPEP 7 SER F 26 PRO F 27 0 -6.66 CISPEP 8 HIS F 99 PRO F 100 0 -2.86 CISPEP 9 ASP F 117 PRO F 118 0 0.09 CISPEP 10 SER J 26 PRO J 27 0 -4.23 CISPEP 11 HIS J 99 PRO J 100 0 -4.85 CISPEP 12 ASP J 117 PRO J 118 0 -8.93 CISPEP 13 SER L 27 PRO L 28 0 -19.27 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000