HEADER MEMBRANE PROTEIN 02-FEB-24 8Y69 TITLE LGR4-RSPO2-ZNRF3 (2:2:2) COMPND MOL_ID: 1; COMPND 2 MOLECULE: LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR COMPND 3 4; COMPND 4 CHAIN: A, D; COMPND 5 SYNONYM: G-PROTEIN COUPLED RECEPTOR 48; COMPND 6 ENGINEERED: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: E3 UBIQUITIN-PROTEIN LIGASE ZNRF3; COMPND 9 CHAIN: C, H; COMPND 10 SYNONYM: RING FINGER PROTEIN 203,RING-TYPE E3 UBIQUITIN TRANSFERASE COMPND 11 ZNRF3,ZINC/RING FINGER PROTEIN 3; COMPND 12 EC: 2.3.2.27; COMPND 13 ENGINEERED: YES; COMPND 14 MOL_ID: 3; COMPND 15 MOLECULE: MB52; COMPND 16 CHAIN: E, I; COMPND 17 ENGINEERED: YES; COMPND 18 MOL_ID: 4; COMPND 19 MOLECULE: R-SPONDIN-2; COMPND 20 CHAIN: G, J; COMPND 21 SYNONYM: CYSTEINE-RICH AND SINGLE THROMBOSPONDIN DOMAIN-CONTAINING COMPND 22 PROTEIN 2,CRISTIN-2,MCRISTIN-2,ROOF PLATE-SPECIFIC SPONDIN-2; COMPND 23 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: LGR4, GPR48; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 GENE: ZNRF3, KIAA1133, RNF203; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: CAMELUS BACTRIANUS; SOURCE 17 ORGANISM_TAXID: 9837; SOURCE 18 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 20 MOL_ID: 4; SOURCE 21 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 22 ORGANISM_COMMON: HUMAN; SOURCE 23 ORGANISM_TAXID: 9606; SOURCE 24 GENE: RSPO2; SOURCE 25 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS LGR4, RSPO2, ZNRF3, 2:2:2, MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR L.WANG,Y.GENG REVDAT 1 04-DEC-24 8Y69 0 JRNL AUTH L.WANG JRNL TITL LGR4-RSPO2-ZNRF3 (2:2:2) JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.38 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.380 REMARK 3 NUMBER OF PARTICLES : 47438 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8Y69 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 05-FEB-24. REMARK 100 THE DEPOSITION ID IS D_1300044994. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : THE DI-HETEROTRIMER COMPLEX OF REMARK 245 LGR4-RSPO2-ZNRF3(DELETE RING REMARK 245 DOMAIN) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TECNAI ARCTICA REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : OTHER REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 194.40 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : OTHER REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: OCTAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, G, D, H, I, J REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ASP A 477 REMARK 465 SER A 478 REMARK 465 TYR A 479 REMARK 465 ALA A 480 REMARK 465 ASN A 481 REMARK 465 LEU A 482 REMARK 465 ASN A 483 REMARK 465 THR A 484 REMARK 465 GLU A 485 REMARK 465 ASP A 486 REMARK 465 ASN A 487 REMARK 465 SER A 488 REMARK 465 LEU A 489 REMARK 465 GLN A 490 REMARK 465 ASP A 491 REMARK 465 HIS A 492 REMARK 465 SER A 493 REMARK 465 VAL A 494 REMARK 465 ALA A 495 REMARK 465 GLN A 496 REMARK 465 GLU A 497 REMARK 465 LYS A 498 REMARK 465 GLY A 499 REMARK 465 THR A 500 REMARK 465 ALA A 501 REMARK 465 ASP A 502 REMARK 465 ALA A 503 REMARK 465 ALA A 504 REMARK 465 ASN A 505 REMARK 465 VAL A 506 REMARK 465 THR A 507 REMARK 465 SER A 508 REMARK 465 THR A 509 REMARK 465 LEU A 510 REMARK 465 GLU A 511 REMARK 465 ASN A 512 REMARK 465 GLU A 513 REMARK 465 GLU A 514 REMARK 465 HIS A 515 REMARK 465 SER A 516 REMARK 465 GLN A 517 REMARK 465 ALA A 565 REMARK 465 CYS A 566 REMARK 465 ALA A 567 REMARK 465 THR A 568 REMARK 465 SER A 569 REMARK 465 ILE A 650 REMARK 465 MET A 651 REMARK 465 LYS A 652 REMARK 465 ASN A 653 REMARK 465 GLY A 654 REMARK 465 LYS A 655 REMARK 465 SER A 656 REMARK 465 LYS A 734 REMARK 465 GLU A 735 REMARK 465 ASP A 736 REMARK 465 LEU A 737 REMARK 465 SER A 738 REMARK 465 SER C 68 REMARK 465 SER C 69 REMARK 465 PRO C 70 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 ASP C 73 REMARK 465 TYR C 74 REMARK 465 MET E 1 REMARK 465 LYS E 2 REMARK 465 LYS E 3 REMARK 465 ILE E 4 REMARK 465 TRP E 5 REMARK 465 LEU E 6 REMARK 465 ALA E 7 REMARK 465 LEU E 8 REMARK 465 ALA E 9 REMARK 465 GLY E 10 REMARK 465 LEU E 11 REMARK 465 VAL E 12 REMARK 465 LEU E 13 REMARK 465 ALA E 14 REMARK 465 PHE E 15 REMARK 465 SER E 16 REMARK 465 ALA E 17 REMARK 465 SER E 18 REMARK 465 ALA E 19 REMARK 465 GLN E 20 REMARK 465 GLY E 27 REMARK 465 GLY E 28 REMARK 465 GLY E 29 REMARK 465 LEU E 30 REMARK 465 VAL E 31 REMARK 465 GLN E 32 REMARK 465 THR E 33 REMARK 465 LYS E 34 REMARK 465 THR E 35 REMARK 465 THR E 36 REMARK 465 THR E 37 REMARK 465 SER E 38 REMARK 465 VAL E 39 REMARK 465 ILE E 40 REMARK 465 ASP E 41 REMARK 465 THR E 42 REMARK 465 THR E 43 REMARK 465 ASN E 44 REMARK 465 ASP E 45 REMARK 465 ALA E 46 REMARK 465 GLN E 47 REMARK 465 ASN E 48 REMARK 465 LEU E 49 REMARK 465 LEU E 50 REMARK 465 THR E 51 REMARK 465 GLN E 52 REMARK 465 ALA E 53 REMARK 465 GLN E 54 REMARK 465 THR E 55 REMARK 465 ILE E 56 REMARK 465 VAL E 57 REMARK 465 ASN E 58 REMARK 465 THR E 59 REMARK 465 LEU E 60 REMARK 465 LYS E 61 REMARK 465 ASP E 62 REMARK 465 TYR E 63 REMARK 465 CYS E 64 REMARK 465 PRO E 65 REMARK 465 ILE E 66 REMARK 465 LEU E 67 REMARK 465 ILE E 68 REMARK 465 ALA E 69 REMARK 465 LYS E 70 REMARK 465 SER E 71 REMARK 465 SER E 72 REMARK 465 SER E 73 REMARK 465 SER E 74 REMARK 465 ASN E 75 REMARK 465 GLY E 76 REMARK 465 GLY E 77 REMARK 465 THR E 78 REMARK 465 ASN E 79 REMARK 465 ASN E 80 REMARK 465 ALA E 81 REMARK 465 ASN E 82 REMARK 465 THR E 83 REMARK 465 PRO E 84 REMARK 465 SER E 85 REMARK 465 TRP E 86 REMARK 465 GLN E 87 REMARK 465 THR E 88 REMARK 465 ALA E 89 REMARK 465 GLY E 90 REMARK 465 GLY E 91 REMARK 465 GLY E 92 REMARK 465 LYS E 93 REMARK 465 ASN E 94 REMARK 465 SER E 95 REMARK 465 CYS E 96 REMARK 465 ALA E 97 REMARK 465 THR E 98 REMARK 465 PHE E 99 REMARK 465 GLY E 100 REMARK 465 ALA E 101 REMARK 465 GLU E 102 REMARK 465 PHE E 103 REMARK 465 SER E 104 REMARK 465 ALA E 105 REMARK 465 ALA E 106 REMARK 465 SER E 107 REMARK 465 ASP E 108 REMARK 465 MET E 109 REMARK 465 ILE E 110 REMARK 465 ASN E 111 REMARK 465 ASN E 112 REMARK 465 ALA E 113 REMARK 465 GLN E 114 REMARK 465 LYS E 115 REMARK 465 ILE E 116 REMARK 465 VAL E 117 REMARK 465 GLN E 118 REMARK 465 GLU E 119 REMARK 465 THR E 120 REMARK 465 GLN E 121 REMARK 465 GLN E 122 REMARK 465 LEU E 123 REMARK 465 SER E 124 REMARK 465 ALA E 125 REMARK 465 ASN E 126 REMARK 465 GLN E 127 REMARK 465 PRO E 128 REMARK 465 LYS E 129 REMARK 465 ASN E 130 REMARK 465 ILE E 131 REMARK 465 THR E 132 REMARK 465 GLN E 133 REMARK 465 PRO E 134 REMARK 465 HIS E 135 REMARK 465 ASN E 136 REMARK 465 LEU E 137 REMARK 465 ASN E 138 REMARK 465 LEU E 139 REMARK 465 ASN E 140 REMARK 465 SER E 141 REMARK 465 PRO E 142 REMARK 465 SER E 143 REMARK 465 SER E 144 REMARK 465 LEU E 145 REMARK 465 THR E 146 REMARK 465 ALA E 147 REMARK 465 LEU E 148 REMARK 465 ALA E 149 REMARK 465 GLN E 150 REMARK 465 LYS E 151 REMARK 465 MET E 152 REMARK 465 LEU E 153 REMARK 465 LYS E 154 REMARK 465 ASN E 155 REMARK 465 ALA E 156 REMARK 465 GLN E 157 REMARK 465 SER E 158 REMARK 465 GLN E 159 REMARK 465 ALA E 160 REMARK 465 GLU E 161 REMARK 465 ILE E 162 REMARK 465 LEU E 163 REMARK 465 LYS E 164 REMARK 465 LEU E 165 REMARK 465 ALA E 166 REMARK 465 ASN E 167 REMARK 465 GLN E 168 REMARK 465 VAL E 169 REMARK 465 GLU E 170 REMARK 465 SER E 171 REMARK 465 ASP E 172 REMARK 465 PHE E 173 REMARK 465 ASN E 174 REMARK 465 LYS E 175 REMARK 465 LEU E 176 REMARK 465 SER E 177 REMARK 465 SER E 178 REMARK 465 GLY E 179 REMARK 465 HIS E 180 REMARK 465 LEU E 181 REMARK 465 LYS E 182 REMARK 465 ASP E 183 REMARK 465 TYR E 184 REMARK 465 ILE E 185 REMARK 465 GLY E 186 REMARK 465 LYS E 187 REMARK 465 CYS E 188 REMARK 465 ASP E 189 REMARK 465 ALA E 190 REMARK 465 SER E 191 REMARK 465 ALA E 192 REMARK 465 ILE E 193 REMARK 465 SER E 194 REMARK 465 SER E 195 REMARK 465 ALA E 196 REMARK 465 ASN E 197 REMARK 465 MET E 198 REMARK 465 THR E 199 REMARK 465 MET E 200 REMARK 465 GLN E 201 REMARK 465 ASN E 202 REMARK 465 GLN E 203 REMARK 465 LYS E 204 REMARK 465 ASN E 205 REMARK 465 ASN E 206 REMARK 465 TRP E 207 REMARK 465 GLY E 208 REMARK 465 ASN E 209 REMARK 465 GLY E 210 REMARK 465 CYS E 211 REMARK 465 ALA E 212 REMARK 465 GLY E 213 REMARK 465 VAL E 214 REMARK 465 GLU E 215 REMARK 465 GLU E 216 REMARK 465 THR E 217 REMARK 465 GLN E 218 REMARK 465 SER E 219 REMARK 465 LEU E 220 REMARK 465 LEU E 221 REMARK 465 LYS E 222 REMARK 465 THR E 223 REMARK 465 SER E 224 REMARK 465 ALA E 225 REMARK 465 ALA E 226 REMARK 465 ASP E 227 REMARK 465 PHE E 228 REMARK 465 ASN E 229 REMARK 465 ASN E 230 REMARK 465 GLN E 231 REMARK 465 THR E 232 REMARK 465 PRO E 233 REMARK 465 GLN E 234 REMARK 465 ILE E 235 REMARK 465 ASN E 236 REMARK 465 GLN E 237 REMARK 465 ALA E 238 REMARK 465 GLN E 239 REMARK 465 ASN E 240 REMARK 465 LEU E 241 REMARK 465 ALA E 242 REMARK 465 ASN E 243 REMARK 465 THR E 244 REMARK 465 LEU E 245 REMARK 465 ILE E 246 REMARK 465 GLN E 247 REMARK 465 GLU E 248 REMARK 465 LEU E 249 REMARK 465 GLY E 250 REMARK 465 ASN E 251 REMARK 465 ASN E 252 REMARK 465 PRO E 253 REMARK 465 PHE E 254 REMARK 465 ARG E 255 REMARK 465 ALA E 256 REMARK 465 SER E 257 REMARK 465 GLY E 258 REMARK 465 GLY E 259 REMARK 465 GLY E 260 REMARK 465 SER E 261 REMARK 465 GLY E 262 REMARK 465 GLY E 263 REMARK 465 GLY E 264 REMARK 465 GLY E 265 REMARK 465 SER E 266 REMARK 465 GLY E 267 REMARK 465 LYS E 268 REMARK 465 LEU E 269 REMARK 465 SER E 270 REMARK 465 ASP E 271 REMARK 465 THR E 272 REMARK 465 TYR E 273 REMARK 465 GLU E 274 REMARK 465 GLN E 275 REMARK 465 LEU E 276 REMARK 465 SER E 277 REMARK 465 ARG E 278 REMARK 465 LEU E 279 REMARK 465 LEU E 280 REMARK 465 THR E 281 REMARK 465 ASN E 282 REMARK 465 ASP E 283 REMARK 465 ASN E 284 REMARK 465 GLY E 285 REMARK 465 THR E 286 REMARK 465 ASN E 287 REMARK 465 SER E 288 REMARK 465 LYS E 289 REMARK 465 THR E 290 REMARK 465 SER E 291 REMARK 465 ALA E 292 REMARK 465 GLN E 293 REMARK 465 ALA E 294 REMARK 465 ILE E 295 REMARK 465 ASN E 296 REMARK 465 GLN E 297 REMARK 465 ALA E 298 REMARK 465 VAL E 299 REMARK 465 ASN E 300 REMARK 465 ASN E 301 REMARK 465 LEU E 302 REMARK 465 ASN E 303 REMARK 465 GLU E 304 REMARK 465 ARG E 305 REMARK 465 ALA E 306 REMARK 465 LYS E 307 REMARK 465 THR E 308 REMARK 465 LEU E 309 REMARK 465 ALA E 310 REMARK 465 GLY E 311 REMARK 465 GLY E 312 REMARK 465 THR E 313 REMARK 465 THR E 314 REMARK 465 ASN E 315 REMARK 465 SER E 316 REMARK 465 PRO E 317 REMARK 465 ALA E 318 REMARK 465 TYR E 319 REMARK 465 GLN E 320 REMARK 465 ALA E 321 REMARK 465 THR E 322 REMARK 465 LEU E 323 REMARK 465 LEU E 324 REMARK 465 ALA E 325 REMARK 465 LEU E 326 REMARK 465 ARG E 327 REMARK 465 SER E 328 REMARK 465 VAL E 329 REMARK 465 LEU E 330 REMARK 465 GLY E 331 REMARK 465 LEU E 332 REMARK 465 TRP E 333 REMARK 465 ASN E 334 REMARK 465 SER E 335 REMARK 465 MET E 336 REMARK 465 GLY E 337 REMARK 465 TYR E 338 REMARK 465 ALA E 339 REMARK 465 VAL E 340 REMARK 465 ILE E 341 REMARK 465 CYS E 342 REMARK 465 GLY E 343 REMARK 465 GLY E 344 REMARK 465 TYR E 345 REMARK 465 THR E 346 REMARK 465 LYS E 347 REMARK 465 SER E 348 REMARK 465 PRO E 349 REMARK 465 GLY E 350 REMARK 465 GLU E 351 REMARK 465 ASN E 352 REMARK 465 ASN E 353 REMARK 465 GLN E 354 REMARK 465 LYS E 355 REMARK 465 ASP E 356 REMARK 465 PHE E 357 REMARK 465 HIS E 358 REMARK 465 TYR E 359 REMARK 465 THR E 360 REMARK 465 ASP E 361 REMARK 465 GLU E 362 REMARK 465 ASN E 363 REMARK 465 GLY E 364 REMARK 465 ASN E 365 REMARK 465 GLY E 366 REMARK 465 THR E 367 REMARK 465 THR E 368 REMARK 465 ILE E 369 REMARK 465 ASN E 370 REMARK 465 CYS E 371 REMARK 465 GLY E 372 REMARK 465 GLY E 373 REMARK 465 SER E 374 REMARK 465 THR E 375 REMARK 465 ASN E 376 REMARK 465 SER E 377 REMARK 465 ASN E 378 REMARK 465 GLY E 379 REMARK 465 THR E 380 REMARK 465 HIS E 381 REMARK 465 SER E 382 REMARK 465 TYR E 383 REMARK 465 ASN E 384 REMARK 465 GLY E 385 REMARK 465 THR E 386 REMARK 465 ASN E 387 REMARK 465 THR E 388 REMARK 465 LEU E 389 REMARK 465 LYS E 390 REMARK 465 ALA E 391 REMARK 465 ASP E 392 REMARK 465 LYS E 393 REMARK 465 ASN E 394 REMARK 465 VAL E 395 REMARK 465 SER E 396 REMARK 465 LEU E 397 REMARK 465 SER E 398 REMARK 465 ILE E 399 REMARK 465 GLU E 400 REMARK 465 GLN E 401 REMARK 465 TYR E 402 REMARK 465 GLU E 403 REMARK 465 LYS E 404 REMARK 465 ILE E 405 REMARK 465 HIS E 406 REMARK 465 GLU E 407 REMARK 465 ALA E 408 REMARK 465 TYR E 409 REMARK 465 GLN E 410 REMARK 465 ILE E 411 REMARK 465 LEU E 412 REMARK 465 SER E 413 REMARK 465 LYS E 414 REMARK 465 ALA E 415 REMARK 465 LEU E 416 REMARK 465 LYS E 417 REMARK 465 GLN E 418 REMARK 465 ALA E 419 REMARK 465 GLY E 420 REMARK 465 LEU E 421 REMARK 465 ALA E 422 REMARK 465 PRO E 423 REMARK 465 LEU E 424 REMARK 465 ASN E 425 REMARK 465 SER E 426 REMARK 465 LYS E 427 REMARK 465 GLY E 428 REMARK 465 GLU E 429 REMARK 465 LYS E 430 REMARK 465 LEU E 431 REMARK 465 GLU E 432 REMARK 465 ALA E 433 REMARK 465 HIS E 434 REMARK 465 VAL E 435 REMARK 465 THR E 436 REMARK 465 THR E 437 REMARK 465 SER E 438 REMARK 465 LYS E 439 REMARK 465 TYR E 440 REMARK 465 GLY E 441 REMARK 465 SER E 550 REMARK 465 HIS E 551 REMARK 465 HIS E 552 REMARK 465 HIS E 553 REMARK 465 HIS E 554 REMARK 465 HIS E 555 REMARK 465 HIS E 556 REMARK 465 GLU E 557 REMARK 465 PRO E 558 REMARK 465 GLU E 559 REMARK 465 ALA E 560 REMARK 465 ASP D 477 REMARK 465 SER D 478 REMARK 465 TYR D 479 REMARK 465 ALA D 480 REMARK 465 ASN D 481 REMARK 465 LEU D 482 REMARK 465 ASN D 483 REMARK 465 THR D 484 REMARK 465 GLU D 485 REMARK 465 ASP D 486 REMARK 465 ASN D 487 REMARK 465 SER D 488 REMARK 465 LEU D 489 REMARK 465 GLN D 490 REMARK 465 ASP D 491 REMARK 465 HIS D 492 REMARK 465 SER D 493 REMARK 465 VAL D 494 REMARK 465 ALA D 495 REMARK 465 GLN D 496 REMARK 465 GLU D 497 REMARK 465 LYS D 498 REMARK 465 GLY D 499 REMARK 465 THR D 500 REMARK 465 ALA D 501 REMARK 465 ASP D 502 REMARK 465 ALA D 503 REMARK 465 ALA D 504 REMARK 465 ASN D 505 REMARK 465 VAL D 506 REMARK 465 THR D 507 REMARK 465 SER D 508 REMARK 465 THR D 509 REMARK 465 LEU D 510 REMARK 465 GLU D 511 REMARK 465 ASN D 512 REMARK 465 GLU D 513 REMARK 465 GLU D 514 REMARK 465 HIS D 515 REMARK 465 SER D 516 REMARK 465 GLN D 517 REMARK 465 ILE D 650 REMARK 465 MET D 651 REMARK 465 LYS D 652 REMARK 465 ASN D 653 REMARK 465 GLY D 654 REMARK 465 LYS D 655 REMARK 465 SER D 656 REMARK 465 LYS D 734 REMARK 465 GLU D 735 REMARK 465 ASP D 736 REMARK 465 LEU D 737 REMARK 465 SER D 738 REMARK 465 SER H 68 REMARK 465 SER H 69 REMARK 465 PRO H 70 REMARK 465 SER H 71 REMARK 465 GLY H 72 REMARK 465 ASP H 73 REMARK 465 TYR H 74 REMARK 465 PRO H 213 REMARK 465 THR H 214 REMARK 465 MET I 1 REMARK 465 LYS I 2 REMARK 465 LYS I 3 REMARK 465 ILE I 4 REMARK 465 TRP I 5 REMARK 465 LEU I 6 REMARK 465 ALA I 7 REMARK 465 LEU I 8 REMARK 465 ALA I 9 REMARK 465 GLY I 10 REMARK 465 LEU I 11 REMARK 465 VAL I 12 REMARK 465 LEU I 13 REMARK 465 ALA I 14 REMARK 465 PHE I 15 REMARK 465 SER I 16 REMARK 465 ALA I 17 REMARK 465 SER I 18 REMARK 465 ALA I 19 REMARK 465 GLN I 20 REMARK 465 GLY I 27 REMARK 465 GLY I 28 REMARK 465 GLY I 29 REMARK 465 LEU I 30 REMARK 465 VAL I 31 REMARK 465 GLN I 32 REMARK 465 THR I 33 REMARK 465 LYS I 34 REMARK 465 THR I 35 REMARK 465 THR I 36 REMARK 465 THR I 37 REMARK 465 SER I 38 REMARK 465 VAL I 39 REMARK 465 ILE I 40 REMARK 465 ASP I 41 REMARK 465 THR I 42 REMARK 465 THR I 43 REMARK 465 ASN I 44 REMARK 465 ASP I 45 REMARK 465 ALA I 46 REMARK 465 GLN I 47 REMARK 465 ASN I 48 REMARK 465 LEU I 49 REMARK 465 LEU I 50 REMARK 465 THR I 51 REMARK 465 GLN I 52 REMARK 465 ALA I 53 REMARK 465 GLN I 54 REMARK 465 THR I 55 REMARK 465 ILE I 56 REMARK 465 VAL I 57 REMARK 465 ASN I 58 REMARK 465 THR I 59 REMARK 465 LEU I 60 REMARK 465 LYS I 61 REMARK 465 ASP I 62 REMARK 465 TYR I 63 REMARK 465 CYS I 64 REMARK 465 PRO I 65 REMARK 465 ILE I 66 REMARK 465 LEU I 67 REMARK 465 ILE I 68 REMARK 465 ALA I 69 REMARK 465 LYS I 70 REMARK 465 SER I 71 REMARK 465 SER I 72 REMARK 465 SER I 73 REMARK 465 SER I 74 REMARK 465 ASN I 75 REMARK 465 GLY I 76 REMARK 465 GLY I 77 REMARK 465 THR I 78 REMARK 465 ASN I 79 REMARK 465 ASN I 80 REMARK 465 ALA I 81 REMARK 465 ASN I 82 REMARK 465 THR I 83 REMARK 465 PRO I 84 REMARK 465 SER I 85 REMARK 465 TRP I 86 REMARK 465 GLN I 87 REMARK 465 THR I 88 REMARK 465 ALA I 89 REMARK 465 GLY I 90 REMARK 465 GLY I 91 REMARK 465 GLY I 92 REMARK 465 LYS I 93 REMARK 465 ASN I 94 REMARK 465 SER I 95 REMARK 465 CYS I 96 REMARK 465 ALA I 97 REMARK 465 THR I 98 REMARK 465 PHE I 99 REMARK 465 GLY I 100 REMARK 465 ALA I 101 REMARK 465 GLU I 102 REMARK 465 PHE I 103 REMARK 465 SER I 104 REMARK 465 ALA I 105 REMARK 465 ALA I 106 REMARK 465 SER I 107 REMARK 465 ASP I 108 REMARK 465 MET I 109 REMARK 465 ILE I 110 REMARK 465 ASN I 111 REMARK 465 ASN I 112 REMARK 465 ALA I 113 REMARK 465 GLN I 114 REMARK 465 LYS I 115 REMARK 465 ILE I 116 REMARK 465 VAL I 117 REMARK 465 GLN I 118 REMARK 465 GLU I 119 REMARK 465 THR I 120 REMARK 465 GLN I 121 REMARK 465 GLN I 122 REMARK 465 LEU I 123 REMARK 465 SER I 124 REMARK 465 ALA I 125 REMARK 465 ASN I 126 REMARK 465 GLN I 127 REMARK 465 PRO I 128 REMARK 465 LYS I 129 REMARK 465 ASN I 130 REMARK 465 ILE I 131 REMARK 465 THR I 132 REMARK 465 GLN I 133 REMARK 465 PRO I 134 REMARK 465 HIS I 135 REMARK 465 ASN I 136 REMARK 465 LEU I 137 REMARK 465 ASN I 138 REMARK 465 LEU I 139 REMARK 465 ASN I 140 REMARK 465 SER I 141 REMARK 465 PRO I 142 REMARK 465 SER I 143 REMARK 465 SER I 144 REMARK 465 LEU I 145 REMARK 465 THR I 146 REMARK 465 ALA I 147 REMARK 465 LEU I 148 REMARK 465 ALA I 149 REMARK 465 GLN I 150 REMARK 465 LYS I 151 REMARK 465 MET I 152 REMARK 465 LEU I 153 REMARK 465 LYS I 154 REMARK 465 ASN I 155 REMARK 465 ALA I 156 REMARK 465 GLN I 157 REMARK 465 SER I 158 REMARK 465 GLN I 159 REMARK 465 ALA I 160 REMARK 465 GLU I 161 REMARK 465 ILE I 162 REMARK 465 LEU I 163 REMARK 465 LYS I 164 REMARK 465 LEU I 165 REMARK 465 ALA I 166 REMARK 465 ASN I 167 REMARK 465 GLN I 168 REMARK 465 VAL I 169 REMARK 465 GLU I 170 REMARK 465 SER I 171 REMARK 465 ASP I 172 REMARK 465 PHE I 173 REMARK 465 ASN I 174 REMARK 465 LYS I 175 REMARK 465 LEU I 176 REMARK 465 SER I 177 REMARK 465 SER I 178 REMARK 465 GLY I 179 REMARK 465 HIS I 180 REMARK 465 LEU I 181 REMARK 465 LYS I 182 REMARK 465 ASP I 183 REMARK 465 TYR I 184 REMARK 465 ILE I 185 REMARK 465 GLY I 186 REMARK 465 LYS I 187 REMARK 465 CYS I 188 REMARK 465 ASP I 189 REMARK 465 ALA I 190 REMARK 465 SER I 191 REMARK 465 ALA I 192 REMARK 465 ILE I 193 REMARK 465 SER I 194 REMARK 465 SER I 195 REMARK 465 ALA I 196 REMARK 465 ASN I 197 REMARK 465 MET I 198 REMARK 465 THR I 199 REMARK 465 MET I 200 REMARK 465 GLN I 201 REMARK 465 ASN I 202 REMARK 465 GLN I 203 REMARK 465 LYS I 204 REMARK 465 ASN I 205 REMARK 465 ASN I 206 REMARK 465 TRP I 207 REMARK 465 GLY I 208 REMARK 465 ASN I 209 REMARK 465 GLY I 210 REMARK 465 CYS I 211 REMARK 465 ALA I 212 REMARK 465 GLY I 213 REMARK 465 VAL I 214 REMARK 465 GLU I 215 REMARK 465 GLU I 216 REMARK 465 THR I 217 REMARK 465 GLN I 218 REMARK 465 SER I 219 REMARK 465 LEU I 220 REMARK 465 LEU I 221 REMARK 465 LYS I 222 REMARK 465 THR I 223 REMARK 465 SER I 224 REMARK 465 ALA I 225 REMARK 465 ALA I 226 REMARK 465 ASP I 227 REMARK 465 PHE I 228 REMARK 465 ASN I 229 REMARK 465 ASN I 230 REMARK 465 GLN I 231 REMARK 465 THR I 232 REMARK 465 PRO I 233 REMARK 465 GLN I 234 REMARK 465 ILE I 235 REMARK 465 ASN I 236 REMARK 465 GLN I 237 REMARK 465 ALA I 238 REMARK 465 GLN I 239 REMARK 465 ASN I 240 REMARK 465 LEU I 241 REMARK 465 ALA I 242 REMARK 465 ASN I 243 REMARK 465 THR I 244 REMARK 465 LEU I 245 REMARK 465 ILE I 246 REMARK 465 GLN I 247 REMARK 465 GLU I 248 REMARK 465 LEU I 249 REMARK 465 GLY I 250 REMARK 465 ASN I 251 REMARK 465 ASN I 252 REMARK 465 PRO I 253 REMARK 465 PHE I 254 REMARK 465 ARG I 255 REMARK 465 ALA I 256 REMARK 465 SER I 257 REMARK 465 GLY I 258 REMARK 465 GLY I 259 REMARK 465 GLY I 260 REMARK 465 SER I 261 REMARK 465 GLY I 262 REMARK 465 GLY I 263 REMARK 465 GLY I 264 REMARK 465 GLY I 265 REMARK 465 SER I 266 REMARK 465 GLY I 267 REMARK 465 LYS I 268 REMARK 465 LEU I 269 REMARK 465 SER I 270 REMARK 465 ASP I 271 REMARK 465 THR I 272 REMARK 465 TYR I 273 REMARK 465 GLU I 274 REMARK 465 GLN I 275 REMARK 465 LEU I 276 REMARK 465 SER I 277 REMARK 465 ARG I 278 REMARK 465 LEU I 279 REMARK 465 LEU I 280 REMARK 465 THR I 281 REMARK 465 ASN I 282 REMARK 465 ASP I 283 REMARK 465 ASN I 284 REMARK 465 GLY I 285 REMARK 465 THR I 286 REMARK 465 ASN I 287 REMARK 465 SER I 288 REMARK 465 LYS I 289 REMARK 465 THR I 290 REMARK 465 SER I 291 REMARK 465 ALA I 292 REMARK 465 GLN I 293 REMARK 465 ALA I 294 REMARK 465 ILE I 295 REMARK 465 ASN I 296 REMARK 465 GLN I 297 REMARK 465 ALA I 298 REMARK 465 VAL I 299 REMARK 465 ASN I 300 REMARK 465 ASN I 301 REMARK 465 LEU I 302 REMARK 465 ASN I 303 REMARK 465 GLU I 304 REMARK 465 ARG I 305 REMARK 465 ALA I 306 REMARK 465 LYS I 307 REMARK 465 THR I 308 REMARK 465 LEU I 309 REMARK 465 ALA I 310 REMARK 465 GLY I 311 REMARK 465 GLY I 312 REMARK 465 THR I 313 REMARK 465 THR I 314 REMARK 465 ASN I 315 REMARK 465 SER I 316 REMARK 465 PRO I 317 REMARK 465 ALA I 318 REMARK 465 TYR I 319 REMARK 465 GLN I 320 REMARK 465 ALA I 321 REMARK 465 THR I 322 REMARK 465 LEU I 323 REMARK 465 LEU I 324 REMARK 465 ALA I 325 REMARK 465 LEU I 326 REMARK 465 ARG I 327 REMARK 465 SER I 328 REMARK 465 VAL I 329 REMARK 465 LEU I 330 REMARK 465 GLY I 331 REMARK 465 LEU I 332 REMARK 465 TRP I 333 REMARK 465 ASN I 334 REMARK 465 SER I 335 REMARK 465 MET I 336 REMARK 465 GLY I 337 REMARK 465 TYR I 338 REMARK 465 ALA I 339 REMARK 465 VAL I 340 REMARK 465 ILE I 341 REMARK 465 CYS I 342 REMARK 465 GLY I 343 REMARK 465 GLY I 344 REMARK 465 TYR I 345 REMARK 465 THR I 346 REMARK 465 LYS I 347 REMARK 465 SER I 348 REMARK 465 PRO I 349 REMARK 465 GLY I 350 REMARK 465 GLU I 351 REMARK 465 ASN I 352 REMARK 465 ASN I 353 REMARK 465 GLN I 354 REMARK 465 LYS I 355 REMARK 465 ASP I 356 REMARK 465 PHE I 357 REMARK 465 HIS I 358 REMARK 465 TYR I 359 REMARK 465 THR I 360 REMARK 465 ASP I 361 REMARK 465 GLU I 362 REMARK 465 ASN I 363 REMARK 465 GLY I 364 REMARK 465 ASN I 365 REMARK 465 GLY I 366 REMARK 465 THR I 367 REMARK 465 THR I 368 REMARK 465 ILE I 369 REMARK 465 ASN I 370 REMARK 465 CYS I 371 REMARK 465 GLY I 372 REMARK 465 GLY I 373 REMARK 465 SER I 374 REMARK 465 THR I 375 REMARK 465 ASN I 376 REMARK 465 SER I 377 REMARK 465 ASN I 378 REMARK 465 GLY I 379 REMARK 465 THR I 380 REMARK 465 HIS I 381 REMARK 465 SER I 382 REMARK 465 TYR I 383 REMARK 465 ASN I 384 REMARK 465 GLY I 385 REMARK 465 THR I 386 REMARK 465 ASN I 387 REMARK 465 THR I 388 REMARK 465 LEU I 389 REMARK 465 LYS I 390 REMARK 465 ALA I 391 REMARK 465 ASP I 392 REMARK 465 LYS I 393 REMARK 465 ASN I 394 REMARK 465 VAL I 395 REMARK 465 SER I 396 REMARK 465 LEU I 397 REMARK 465 SER I 398 REMARK 465 ILE I 399 REMARK 465 GLU I 400 REMARK 465 GLN I 401 REMARK 465 TYR I 402 REMARK 465 GLU I 403 REMARK 465 LYS I 404 REMARK 465 ILE I 405 REMARK 465 HIS I 406 REMARK 465 GLU I 407 REMARK 465 ALA I 408 REMARK 465 TYR I 409 REMARK 465 GLN I 410 REMARK 465 ILE I 411 REMARK 465 LEU I 412 REMARK 465 SER I 413 REMARK 465 LYS I 414 REMARK 465 ALA I 415 REMARK 465 LEU I 416 REMARK 465 LYS I 417 REMARK 465 GLN I 418 REMARK 465 ALA I 419 REMARK 465 GLY I 420 REMARK 465 LEU I 421 REMARK 465 ALA I 422 REMARK 465 PRO I 423 REMARK 465 LEU I 424 REMARK 465 ASN I 425 REMARK 465 SER I 426 REMARK 465 LYS I 427 REMARK 465 GLY I 428 REMARK 465 GLU I 429 REMARK 465 LYS I 430 REMARK 465 LEU I 431 REMARK 465 GLU I 432 REMARK 465 ALA I 433 REMARK 465 HIS I 434 REMARK 465 VAL I 435 REMARK 465 THR I 436 REMARK 465 THR I 437 REMARK 465 SER I 438 REMARK 465 LYS I 439 REMARK 465 TYR I 440 REMARK 465 GLY I 441 REMARK 465 SER I 550 REMARK 465 HIS I 551 REMARK 465 HIS I 552 REMARK 465 HIS I 553 REMARK 465 HIS I 554 REMARK 465 HIS I 555 REMARK 465 HIS I 556 REMARK 465 GLU I 557 REMARK 465 PRO I 558 REMARK 465 GLU I 559 REMARK 465 ALA I 560 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 TYR A 725 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LEU A 728 CG CD1 CD2 REMARK 470 LYS C 56 CG CD CE NZ REMARK 470 LYS C 243 CG CD CE NZ REMARK 470 LYS E 500 CG CD CE NZ REMARK 470 ARG G 54 CG CD NE CZ NH1 NH2 REMARK 470 GLN G 57 CG CD OE1 NE2 REMARK 470 GLU G 137 CG CD OE1 OE2 REMARK 470 MET D 745 CG SD CE REMARK 470 LYS H 56 CG CD CE NZ REMARK 470 ARG H 87 CG CD NE CZ NH1 NH2 REMARK 470 ARG H 208 CG CD NE CZ NH1 NH2 REMARK 470 ARG H 211 CG CD NE CZ NH1 NH2 REMARK 470 GLN H 212 CG CD OE1 NE2 REMARK 470 GLU H 215 CG CD OE1 OE2 REMARK 470 TYR H 216 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LYS H 243 CG CD CE NZ REMARK 470 ARG J 54 CG CD NE CZ NH1 NH2 REMARK 470 GLN J 57 CG CD OE1 NE2 REMARK 470 GLU J 137 CG CD OE1 OE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG1 THR A 526 O LYS A 530 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA A 185 -60.77 -90.93 REMARK 500 VAL A 204 -53.41 -122.06 REMARK 500 PHE A 240 138.36 -171.66 REMARK 500 ASN A 294 47.18 38.96 REMARK 500 SER A 296 1.90 -67.57 REMARK 500 THR A 316 1.02 -68.25 REMARK 500 SER A 351 -64.81 -95.57 REMARK 500 ARG A 374 9.34 54.40 REMARK 500 LEU A 396 21.51 -141.21 REMARK 500 SER A 688 47.64 -86.22 REMARK 500 PRO A 695 47.66 -85.21 REMARK 500 PHE A 696 -28.73 -162.83 REMARK 500 LEU C 106 57.14 -94.42 REMARK 500 SER E 455 71.53 52.89 REMARK 500 SER G 80 135.84 -171.19 REMARK 500 PHE D 58 53.39 -90.00 REMARK 500 PHE D 82 52.95 -90.49 REMARK 500 ASN D 210 -3.62 -145.28 REMARK 500 VAL D 287 -51.73 -124.90 REMARK 500 GLU D 341 -166.64 -128.57 REMARK 500 SER D 351 -67.28 -96.82 REMARK 500 PHE D 361 51.14 -91.15 REMARK 500 ARG D 374 6.79 57.67 REMARK 500 PHE D 385 55.04 -95.53 REMARK 500 ILE D 772 114.28 66.27 REMARK 500 LEU H 106 57.11 -95.20 REMARK 500 ARG H 211 -137.26 57.85 REMARK 500 TYR I 454 -175.83 -174.05 REMARK 500 SER I 455 71.02 48.92 REMARK 500 ALA I 516 -169.51 -161.31 REMARK 500 ARG J 54 116.06 -161.37 REMARK 500 GLN J 56 -73.76 -79.14 REMARK 500 GLN J 57 -41.70 -137.09 REMARK 500 SER J 80 140.93 -172.26 REMARK 500 HIS J 120 -60.86 -99.02 REMARK 500 PRO J 129 -177.67 -69.45 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-38982 RELATED DB: EMDB REMARK 900 LGR4-RSPO2-ZNRF3 (2:2:2) DBREF 8Y69 A 33 820 UNP Q9BXB1 LGR4_HUMAN 33 820 DBREF 8Y69 C 56 243 UNP Q9ULT6 ZNRF3_HUMAN 56 243 DBREF 8Y69 E 1 560 PDB 8Y69 8Y69 1 560 DBREF 8Y69 G 41 141 UNP Q8BFU0 RSPO2_MOUSE 41 141 DBREF 8Y69 D 33 820 UNP Q9BXB1 LGR4_HUMAN 33 820 DBREF 8Y69 H 56 243 UNP Q9ULT6 ZNRF3_HUMAN 56 243 DBREF 8Y69 I 1 560 PDB 8Y69 8Y69 1 560 DBREF 8Y69 J 41 141 UNP Q8BFU0 RSPO2_MOUSE 41 141 SEQADV 8Y69 ALA A 78 UNP Q9BXB1 LYS 78 CONFLICT SEQADV 8Y69 CYS A 566 UNP Q9BXB1 SER 566 CONFLICT SEQADV 8Y69 ALA A 567 UNP Q9BXB1 CYS 567 CONFLICT SEQADV 8Y69 ALA G 130 UNP Q8BFU0 ASP 130 CONFLICT SEQADV 8Y69 ALA D 78 UNP Q9BXB1 LYS 78 CONFLICT SEQADV 8Y69 CYS D 566 UNP Q9BXB1 SER 566 CONFLICT SEQADV 8Y69 ALA D 567 UNP Q9BXB1 CYS 567 CONFLICT SEQADV 8Y69 ALA J 130 UNP Q8BFU0 ASP 130 CONFLICT SEQRES 1 A 788 CYS SER CYS ASP GLY ASP ARG ARG VAL ASP CYS SER GLY SEQRES 2 A 788 LYS GLY LEU THR ALA VAL PRO GLU GLY LEU SER ALA PHE SEQRES 3 A 788 THR GLN ALA LEU ASP ILE SER MET ASN ASN ILE THR GLN SEQRES 4 A 788 LEU PRO GLU ASP ALA PHE ALA ASN PHE PRO PHE LEU GLU SEQRES 5 A 788 GLU LEU GLN LEU ALA GLY ASN ASP LEU SER PHE ILE HIS SEQRES 6 A 788 PRO LYS ALA LEU SER GLY LEU LYS GLU LEU LYS VAL LEU SEQRES 7 A 788 THR LEU GLN ASN ASN GLN LEU LYS THR VAL PRO SER GLU SEQRES 8 A 788 ALA ILE ARG GLY LEU SER ALA LEU GLN SER LEU ARG LEU SEQRES 9 A 788 ASP ALA ASN HIS ILE THR SER VAL PRO GLU ASP SER PHE SEQRES 10 A 788 GLU GLY LEU VAL GLN LEU ARG HIS LEU TRP LEU ASP ASP SEQRES 11 A 788 ASN SER LEU THR GLU VAL PRO VAL HIS PRO LEU SER ASN SEQRES 12 A 788 LEU PRO THR LEU GLN ALA LEU THR LEU ALA LEU ASN LYS SEQRES 13 A 788 ILE SER SER ILE PRO ASP PHE ALA PHE THR ASN LEU SER SEQRES 14 A 788 SER LEU VAL VAL LEU HIS LEU HIS ASN ASN LYS ILE ARG SEQRES 15 A 788 SER LEU SER GLN HIS CYS PHE ASP GLY LEU ASP ASN LEU SEQRES 16 A 788 GLU THR LEU ASP LEU ASN TYR ASN ASN LEU GLY GLU PHE SEQRES 17 A 788 PRO GLN ALA ILE LYS ALA LEU PRO SER LEU LYS GLU LEU SEQRES 18 A 788 GLY PHE HIS SER ASN SER ILE SER VAL ILE PRO ASP GLY SEQRES 19 A 788 ALA PHE ASP GLY ASN PRO LEU LEU ARG THR ILE HIS LEU SEQRES 20 A 788 TYR ASP ASN PRO LEU SER PHE VAL GLY ASN SER ALA PHE SEQRES 21 A 788 HIS ASN LEU SER ASP LEU HIS SER LEU VAL ILE ARG GLY SEQRES 22 A 788 ALA SER MET VAL GLN GLN PHE PRO ASN LEU THR GLY THR SEQRES 23 A 788 VAL HIS LEU GLU SER LEU THR LEU THR GLY THR LYS ILE SEQRES 24 A 788 SER SER ILE PRO ASN ASN LEU CYS GLN GLU GLN LYS MET SEQRES 25 A 788 LEU ARG THR LEU ASP LEU SER TYR ASN ASN ILE ARG ASP SEQRES 26 A 788 LEU PRO SER PHE ASN GLY CYS HIS ALA LEU GLU GLU ILE SEQRES 27 A 788 SER LEU GLN ARG ASN GLN ILE TYR GLN ILE LYS GLU GLY SEQRES 28 A 788 THR PHE GLN GLY LEU ILE SER LEU ARG ILE LEU ASP LEU SEQRES 29 A 788 SER ARG ASN LEU ILE HIS GLU ILE HIS SER ARG ALA PHE SEQRES 30 A 788 ALA THR LEU GLY PRO ILE THR ASN LEU ASP VAL SER PHE SEQRES 31 A 788 ASN GLU LEU THR SER PHE PRO THR GLU GLY LEU ASN GLY SEQRES 32 A 788 LEU ASN GLN LEU LYS LEU VAL GLY ASN PHE LYS LEU LYS SEQRES 33 A 788 GLU ALA LEU ALA ALA LYS ASP PHE VAL ASN LEU ARG SER SEQRES 34 A 788 LEU SER VAL PRO TYR ALA TYR GLN CYS CYS ALA PHE TRP SEQRES 35 A 788 GLY CYS ASP SER TYR ALA ASN LEU ASN THR GLU ASP ASN SEQRES 36 A 788 SER LEU GLN ASP HIS SER VAL ALA GLN GLU LYS GLY THR SEQRES 37 A 788 ALA ASP ALA ALA ASN VAL THR SER THR LEU GLU ASN GLU SEQRES 38 A 788 GLU HIS SER GLN ILE ILE ILE HIS CYS THR PRO SER THR SEQRES 39 A 788 GLY ALA PHE LYS PRO CYS GLU TYR LEU LEU GLY SER TRP SEQRES 40 A 788 MET ILE ARG LEU THR VAL TRP PHE ILE PHE LEU VAL ALA SEQRES 41 A 788 LEU PHE PHE ASN LEU LEU VAL ILE LEU THR THR PHE ALA SEQRES 42 A 788 CYS ALA THR SER LEU PRO SER SER LYS LEU PHE ILE GLY SEQRES 43 A 788 LEU ILE SER VAL SER ASN LEU PHE MET GLY ILE TYR THR SEQRES 44 A 788 GLY ILE LEU THR PHE LEU ASP ALA VAL SER TRP GLY ARG SEQRES 45 A 788 PHE ALA GLU PHE GLY ILE TRP TRP GLU THR GLY SER GLY SEQRES 46 A 788 CYS LYS VAL ALA GLY PHE LEU ALA VAL PHE SER SER GLU SEQRES 47 A 788 SER ALA ILE PHE LEU LEU MET LEU ALA THR VAL GLU ARG SEQRES 48 A 788 SER LEU SER ALA LYS ASP ILE MET LYS ASN GLY LYS SER SEQRES 49 A 788 ASN HIS LEU LYS GLN PHE ARG VAL ALA ALA LEU LEU ALA SEQRES 50 A 788 PHE LEU GLY ALA THR VAL ALA GLY CYS PHE PRO LEU PHE SEQRES 51 A 788 HIS ARG GLY GLU TYR SER ALA SER PRO LEU CYS LEU PRO SEQRES 52 A 788 PHE PRO THR GLY GLU THR PRO SER LEU GLY PHE THR VAL SEQRES 53 A 788 THR LEU VAL LEU LEU ASN SER LEU ALA PHE LEU LEU MET SEQRES 54 A 788 ALA VAL ILE TYR THR LYS LEU TYR CYS ASN LEU GLU LYS SEQRES 55 A 788 GLU ASP LEU SER GLU ASN SER GLN SER SER MET ILE LYS SEQRES 56 A 788 HIS VAL ALA TRP LEU ILE PHE THR ASN CYS ILE PHE PHE SEQRES 57 A 788 CYS PRO VAL ALA PHE PHE SER PHE ALA PRO LEU ILE THR SEQRES 58 A 788 ALA ILE SER ILE SER PRO GLU ILE MET LYS SER VAL THR SEQRES 59 A 788 LEU ILE PHE PHE PRO LEU PRO ALA CYS LEU ASN PRO VAL SEQRES 60 A 788 LEU TYR VAL PHE PHE ASN PRO LYS PHE LYS GLU ASP TRP SEQRES 61 A 788 LYS LEU LEU LYS ARG ARG VAL THR SEQRES 1 C 188 LYS GLU THR ALA PHE VAL GLU VAL VAL LEU PHE GLU SER SEQRES 2 C 188 SER PRO SER GLY ASP TYR THR THR TYR THR THR GLY LEU SEQRES 3 C 188 THR GLY ARG PHE SER ARG ALA GLY ALA THR LEU SER ALA SEQRES 4 C 188 GLU GLY GLU ILE VAL GLN MET HIS PRO LEU GLY LEU CYS SEQRES 5 C 188 ASN ASN ASN ASP GLU GLU ASP LEU TYR GLU TYR GLY TRP SEQRES 6 C 188 VAL GLY VAL VAL LYS LEU GLU GLN PRO GLU LEU ASP PRO SEQRES 7 C 188 LYS PRO CYS LEU THR VAL LEU GLY LYS ALA LYS ARG ALA SEQRES 8 C 188 VAL GLN ARG GLY ALA THR ALA VAL ILE PHE ASP VAL SER SEQRES 9 C 188 GLU ASN PRO GLU ALA ILE ASP GLN LEU ASN GLN GLY SER SEQRES 10 C 188 GLU ASP PRO LEU LYS ARG PRO VAL VAL TYR VAL LYS GLY SEQRES 11 C 188 ALA ASP ALA ILE LYS LEU MET ASN ILE VAL ASN LYS GLN SEQRES 12 C 188 LYS VAL ALA ARG ALA ARG ILE GLN HIS ARG PRO PRO ARG SEQRES 13 C 188 GLN PRO THR GLU TYR PHE ASP MET GLY ILE PHE LEU ALA SEQRES 14 C 188 PHE PHE VAL VAL VAL SER LEU VAL CYS LEU ILE LEU LEU SEQRES 15 C 188 VAL LYS ILE LYS LEU LYS SEQRES 1 E 560 MET LYS LYS ILE TRP LEU ALA LEU ALA GLY LEU VAL LEU SEQRES 2 E 560 ALA PHE SER ALA SER ALA GLN VAL GLN LEU VAL GLU SER SEQRES 3 E 560 GLY GLY GLY LEU VAL GLN THR LYS THR THR THR SER VAL SEQRES 4 E 560 ILE ASP THR THR ASN ASP ALA GLN ASN LEU LEU THR GLN SEQRES 5 E 560 ALA GLN THR ILE VAL ASN THR LEU LYS ASP TYR CYS PRO SEQRES 6 E 560 ILE LEU ILE ALA LYS SER SER SER SER ASN GLY GLY THR SEQRES 7 E 560 ASN ASN ALA ASN THR PRO SER TRP GLN THR ALA GLY GLY SEQRES 8 E 560 GLY LYS ASN SER CYS ALA THR PHE GLY ALA GLU PHE SER SEQRES 9 E 560 ALA ALA SER ASP MET ILE ASN ASN ALA GLN LYS ILE VAL SEQRES 10 E 560 GLN GLU THR GLN GLN LEU SER ALA ASN GLN PRO LYS ASN SEQRES 11 E 560 ILE THR GLN PRO HIS ASN LEU ASN LEU ASN SER PRO SER SEQRES 12 E 560 SER LEU THR ALA LEU ALA GLN LYS MET LEU LYS ASN ALA SEQRES 13 E 560 GLN SER GLN ALA GLU ILE LEU LYS LEU ALA ASN GLN VAL SEQRES 14 E 560 GLU SER ASP PHE ASN LYS LEU SER SER GLY HIS LEU LYS SEQRES 15 E 560 ASP TYR ILE GLY LYS CYS ASP ALA SER ALA ILE SER SER SEQRES 16 E 560 ALA ASN MET THR MET GLN ASN GLN LYS ASN ASN TRP GLY SEQRES 17 E 560 ASN GLY CYS ALA GLY VAL GLU GLU THR GLN SER LEU LEU SEQRES 18 E 560 LYS THR SER ALA ALA ASP PHE ASN ASN GLN THR PRO GLN SEQRES 19 E 560 ILE ASN GLN ALA GLN ASN LEU ALA ASN THR LEU ILE GLN SEQRES 20 E 560 GLU LEU GLY ASN ASN PRO PHE ARG ALA SER GLY GLY GLY SEQRES 21 E 560 SER GLY GLY GLY GLY SER GLY LYS LEU SER ASP THR TYR SEQRES 22 E 560 GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY THR SEQRES 23 E 560 ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA VAL SEQRES 24 E 560 ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY GLY SEQRES 25 E 560 THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU ALA SEQRES 26 E 560 LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY TYR SEQRES 27 E 560 ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY GLU SEQRES 28 E 560 ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN GLY SEQRES 29 E 560 ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SER SEQRES 30 E 560 ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU LYS SEQRES 31 E 560 ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR GLU SEQRES 32 E 560 LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA LEU SEQRES 33 E 560 LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY GLU SEQRES 34 E 560 LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SER SEQRES 35 E 560 LEU ARG LEU SER CYS ALA ALA SER GLY TYR THR TYR SER SEQRES 36 E 560 PRO TYR CYS MET GLY TRP PHE ARG GLN ALA PRO GLY LYS SEQRES 37 E 560 ALA ARG GLU GLY VAL ALA THR VAL ASP LEU ASP GLY SER SEQRES 38 E 560 THR ILE TYR ALA ASP SER VAL LYS GLY ARG PHE THR ILE SEQRES 39 E 560 SER GLN ASP ASN ALA LYS ASN THR LEU TYR LEU GLN MET SEQRES 40 E 560 ASN SER LEU LYS PRO GLU ASP THR ALA MET TYR TYR CYS SEQRES 41 E 560 ALA SER ARG THR ARG ALA GLY VAL THR CYS GLY LEU ASN SEQRES 42 E 560 TRP ALA ILE PHE SER TYR TRP GLY GLN GLY THR GLN VAL SEQRES 43 E 560 THR VAL SER SER HIS HIS HIS HIS HIS HIS GLU PRO GLU SEQRES 44 E 560 ALA SEQRES 1 G 101 LYS GLY CYS LEU SER CYS SER LYS ASP ASN GLY CYS SER SEQRES 2 G 101 ARG CYS GLN GLN LYS LEU PHE PHE PHE LEU ARG ARG GLU SEQRES 3 G 101 GLY MET ARG GLN TYR GLY GLU CYS LEU HIS SER CYS PRO SEQRES 4 G 101 SER GLY TYR TYR GLY HIS ARG ALA PRO ASP MET ASN ARG SEQRES 5 G 101 CYS ALA ARG CYS ARG ILE GLU ASN CYS ASP SER CYS PHE SEQRES 6 G 101 SER LYS ASP PHE CYS THR LYS CYS LYS VAL GLY PHE TYR SEQRES 7 G 101 LEU HIS ARG GLY ARG CYS PHE ASP GLU CYS PRO ALA GLY SEQRES 8 G 101 PHE ALA PRO LEU ASP GLU THR MET GLU CYS SEQRES 1 D 788 CYS SER CYS ASP GLY ASP ARG ARG VAL ASP CYS SER GLY SEQRES 2 D 788 LYS GLY LEU THR ALA VAL PRO GLU GLY LEU SER ALA PHE SEQRES 3 D 788 THR GLN ALA LEU ASP ILE SER MET ASN ASN ILE THR GLN SEQRES 4 D 788 LEU PRO GLU ASP ALA PHE ALA ASN PHE PRO PHE LEU GLU SEQRES 5 D 788 GLU LEU GLN LEU ALA GLY ASN ASP LEU SER PHE ILE HIS SEQRES 6 D 788 PRO LYS ALA LEU SER GLY LEU LYS GLU LEU LYS VAL LEU SEQRES 7 D 788 THR LEU GLN ASN ASN GLN LEU LYS THR VAL PRO SER GLU SEQRES 8 D 788 ALA ILE ARG GLY LEU SER ALA LEU GLN SER LEU ARG LEU SEQRES 9 D 788 ASP ALA ASN HIS ILE THR SER VAL PRO GLU ASP SER PHE SEQRES 10 D 788 GLU GLY LEU VAL GLN LEU ARG HIS LEU TRP LEU ASP ASP SEQRES 11 D 788 ASN SER LEU THR GLU VAL PRO VAL HIS PRO LEU SER ASN SEQRES 12 D 788 LEU PRO THR LEU GLN ALA LEU THR LEU ALA LEU ASN LYS SEQRES 13 D 788 ILE SER SER ILE PRO ASP PHE ALA PHE THR ASN LEU SER SEQRES 14 D 788 SER LEU VAL VAL LEU HIS LEU HIS ASN ASN LYS ILE ARG SEQRES 15 D 788 SER LEU SER GLN HIS CYS PHE ASP GLY LEU ASP ASN LEU SEQRES 16 D 788 GLU THR LEU ASP LEU ASN TYR ASN ASN LEU GLY GLU PHE SEQRES 17 D 788 PRO GLN ALA ILE LYS ALA LEU PRO SER LEU LYS GLU LEU SEQRES 18 D 788 GLY PHE HIS SER ASN SER ILE SER VAL ILE PRO ASP GLY SEQRES 19 D 788 ALA PHE ASP GLY ASN PRO LEU LEU ARG THR ILE HIS LEU SEQRES 20 D 788 TYR ASP ASN PRO LEU SER PHE VAL GLY ASN SER ALA PHE SEQRES 21 D 788 HIS ASN LEU SER ASP LEU HIS SER LEU VAL ILE ARG GLY SEQRES 22 D 788 ALA SER MET VAL GLN GLN PHE PRO ASN LEU THR GLY THR SEQRES 23 D 788 VAL HIS LEU GLU SER LEU THR LEU THR GLY THR LYS ILE SEQRES 24 D 788 SER SER ILE PRO ASN ASN LEU CYS GLN GLU GLN LYS MET SEQRES 25 D 788 LEU ARG THR LEU ASP LEU SER TYR ASN ASN ILE ARG ASP SEQRES 26 D 788 LEU PRO SER PHE ASN GLY CYS HIS ALA LEU GLU GLU ILE SEQRES 27 D 788 SER LEU GLN ARG ASN GLN ILE TYR GLN ILE LYS GLU GLY SEQRES 28 D 788 THR PHE GLN GLY LEU ILE SER LEU ARG ILE LEU ASP LEU SEQRES 29 D 788 SER ARG ASN LEU ILE HIS GLU ILE HIS SER ARG ALA PHE SEQRES 30 D 788 ALA THR LEU GLY PRO ILE THR ASN LEU ASP VAL SER PHE SEQRES 31 D 788 ASN GLU LEU THR SER PHE PRO THR GLU GLY LEU ASN GLY SEQRES 32 D 788 LEU ASN GLN LEU LYS LEU VAL GLY ASN PHE LYS LEU LYS SEQRES 33 D 788 GLU ALA LEU ALA ALA LYS ASP PHE VAL ASN LEU ARG SER SEQRES 34 D 788 LEU SER VAL PRO TYR ALA TYR GLN CYS CYS ALA PHE TRP SEQRES 35 D 788 GLY CYS ASP SER TYR ALA ASN LEU ASN THR GLU ASP ASN SEQRES 36 D 788 SER LEU GLN ASP HIS SER VAL ALA GLN GLU LYS GLY THR SEQRES 37 D 788 ALA ASP ALA ALA ASN VAL THR SER THR LEU GLU ASN GLU SEQRES 38 D 788 GLU HIS SER GLN ILE ILE ILE HIS CYS THR PRO SER THR SEQRES 39 D 788 GLY ALA PHE LYS PRO CYS GLU TYR LEU LEU GLY SER TRP SEQRES 40 D 788 MET ILE ARG LEU THR VAL TRP PHE ILE PHE LEU VAL ALA SEQRES 41 D 788 LEU PHE PHE ASN LEU LEU VAL ILE LEU THR THR PHE ALA SEQRES 42 D 788 CYS ALA THR SER LEU PRO SER SER LYS LEU PHE ILE GLY SEQRES 43 D 788 LEU ILE SER VAL SER ASN LEU PHE MET GLY ILE TYR THR SEQRES 44 D 788 GLY ILE LEU THR PHE LEU ASP ALA VAL SER TRP GLY ARG SEQRES 45 D 788 PHE ALA GLU PHE GLY ILE TRP TRP GLU THR GLY SER GLY SEQRES 46 D 788 CYS LYS VAL ALA GLY PHE LEU ALA VAL PHE SER SER GLU SEQRES 47 D 788 SER ALA ILE PHE LEU LEU MET LEU ALA THR VAL GLU ARG SEQRES 48 D 788 SER LEU SER ALA LYS ASP ILE MET LYS ASN GLY LYS SER SEQRES 49 D 788 ASN HIS LEU LYS GLN PHE ARG VAL ALA ALA LEU LEU ALA SEQRES 50 D 788 PHE LEU GLY ALA THR VAL ALA GLY CYS PHE PRO LEU PHE SEQRES 51 D 788 HIS ARG GLY GLU TYR SER ALA SER PRO LEU CYS LEU PRO SEQRES 52 D 788 PHE PRO THR GLY GLU THR PRO SER LEU GLY PHE THR VAL SEQRES 53 D 788 THR LEU VAL LEU LEU ASN SER LEU ALA PHE LEU LEU MET SEQRES 54 D 788 ALA VAL ILE TYR THR LYS LEU TYR CYS ASN LEU GLU LYS SEQRES 55 D 788 GLU ASP LEU SER GLU ASN SER GLN SER SER MET ILE LYS SEQRES 56 D 788 HIS VAL ALA TRP LEU ILE PHE THR ASN CYS ILE PHE PHE SEQRES 57 D 788 CYS PRO VAL ALA PHE PHE SER PHE ALA PRO LEU ILE THR SEQRES 58 D 788 ALA ILE SER ILE SER PRO GLU ILE MET LYS SER VAL THR SEQRES 59 D 788 LEU ILE PHE PHE PRO LEU PRO ALA CYS LEU ASN PRO VAL SEQRES 60 D 788 LEU TYR VAL PHE PHE ASN PRO LYS PHE LYS GLU ASP TRP SEQRES 61 D 788 LYS LEU LEU LYS ARG ARG VAL THR SEQRES 1 H 188 LYS GLU THR ALA PHE VAL GLU VAL VAL LEU PHE GLU SER SEQRES 2 H 188 SER PRO SER GLY ASP TYR THR THR TYR THR THR GLY LEU SEQRES 3 H 188 THR GLY ARG PHE SER ARG ALA GLY ALA THR LEU SER ALA SEQRES 4 H 188 GLU GLY GLU ILE VAL GLN MET HIS PRO LEU GLY LEU CYS SEQRES 5 H 188 ASN ASN ASN ASP GLU GLU ASP LEU TYR GLU TYR GLY TRP SEQRES 6 H 188 VAL GLY VAL VAL LYS LEU GLU GLN PRO GLU LEU ASP PRO SEQRES 7 H 188 LYS PRO CYS LEU THR VAL LEU GLY LYS ALA LYS ARG ALA SEQRES 8 H 188 VAL GLN ARG GLY ALA THR ALA VAL ILE PHE ASP VAL SER SEQRES 9 H 188 GLU ASN PRO GLU ALA ILE ASP GLN LEU ASN GLN GLY SER SEQRES 10 H 188 GLU ASP PRO LEU LYS ARG PRO VAL VAL TYR VAL LYS GLY SEQRES 11 H 188 ALA ASP ALA ILE LYS LEU MET ASN ILE VAL ASN LYS GLN SEQRES 12 H 188 LYS VAL ALA ARG ALA ARG ILE GLN HIS ARG PRO PRO ARG SEQRES 13 H 188 GLN PRO THR GLU TYR PHE ASP MET GLY ILE PHE LEU ALA SEQRES 14 H 188 PHE PHE VAL VAL VAL SER LEU VAL CYS LEU ILE LEU LEU SEQRES 15 H 188 VAL LYS ILE LYS LEU LYS SEQRES 1 I 560 MET LYS LYS ILE TRP LEU ALA LEU ALA GLY LEU VAL LEU SEQRES 2 I 560 ALA PHE SER ALA SER ALA GLN VAL GLN LEU VAL GLU SER SEQRES 3 I 560 GLY GLY GLY LEU VAL GLN THR LYS THR THR THR SER VAL SEQRES 4 I 560 ILE ASP THR THR ASN ASP ALA GLN ASN LEU LEU THR GLN SEQRES 5 I 560 ALA GLN THR ILE VAL ASN THR LEU LYS ASP TYR CYS PRO SEQRES 6 I 560 ILE LEU ILE ALA LYS SER SER SER SER ASN GLY GLY THR SEQRES 7 I 560 ASN ASN ALA ASN THR PRO SER TRP GLN THR ALA GLY GLY SEQRES 8 I 560 GLY LYS ASN SER CYS ALA THR PHE GLY ALA GLU PHE SER SEQRES 9 I 560 ALA ALA SER ASP MET ILE ASN ASN ALA GLN LYS ILE VAL SEQRES 10 I 560 GLN GLU THR GLN GLN LEU SER ALA ASN GLN PRO LYS ASN SEQRES 11 I 560 ILE THR GLN PRO HIS ASN LEU ASN LEU ASN SER PRO SER SEQRES 12 I 560 SER LEU THR ALA LEU ALA GLN LYS MET LEU LYS ASN ALA SEQRES 13 I 560 GLN SER GLN ALA GLU ILE LEU LYS LEU ALA ASN GLN VAL SEQRES 14 I 560 GLU SER ASP PHE ASN LYS LEU SER SER GLY HIS LEU LYS SEQRES 15 I 560 ASP TYR ILE GLY LYS CYS ASP ALA SER ALA ILE SER SER SEQRES 16 I 560 ALA ASN MET THR MET GLN ASN GLN LYS ASN ASN TRP GLY SEQRES 17 I 560 ASN GLY CYS ALA GLY VAL GLU GLU THR GLN SER LEU LEU SEQRES 18 I 560 LYS THR SER ALA ALA ASP PHE ASN ASN GLN THR PRO GLN SEQRES 19 I 560 ILE ASN GLN ALA GLN ASN LEU ALA ASN THR LEU ILE GLN SEQRES 20 I 560 GLU LEU GLY ASN ASN PRO PHE ARG ALA SER GLY GLY GLY SEQRES 21 I 560 SER GLY GLY GLY GLY SER GLY LYS LEU SER ASP THR TYR SEQRES 22 I 560 GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY THR SEQRES 23 I 560 ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA VAL SEQRES 24 I 560 ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY GLY SEQRES 25 I 560 THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU ALA SEQRES 26 I 560 LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY TYR SEQRES 27 I 560 ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY GLU SEQRES 28 I 560 ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN GLY SEQRES 29 I 560 ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SER SEQRES 30 I 560 ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU LYS SEQRES 31 I 560 ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR GLU SEQRES 32 I 560 LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA LEU SEQRES 33 I 560 LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY GLU SEQRES 34 I 560 LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SER SEQRES 35 I 560 LEU ARG LEU SER CYS ALA ALA SER GLY TYR THR TYR SER SEQRES 36 I 560 PRO TYR CYS MET GLY TRP PHE ARG GLN ALA PRO GLY LYS SEQRES 37 I 560 ALA ARG GLU GLY VAL ALA THR VAL ASP LEU ASP GLY SER SEQRES 38 I 560 THR ILE TYR ALA ASP SER VAL LYS GLY ARG PHE THR ILE SEQRES 39 I 560 SER GLN ASP ASN ALA LYS ASN THR LEU TYR LEU GLN MET SEQRES 40 I 560 ASN SER LEU LYS PRO GLU ASP THR ALA MET TYR TYR CYS SEQRES 41 I 560 ALA SER ARG THR ARG ALA GLY VAL THR CYS GLY LEU ASN SEQRES 42 I 560 TRP ALA ILE PHE SER TYR TRP GLY GLN GLY THR GLN VAL SEQRES 43 I 560 THR VAL SER SER HIS HIS HIS HIS HIS HIS GLU PRO GLU SEQRES 44 I 560 ALA SEQRES 1 J 101 LYS GLY CYS LEU SER CYS SER LYS ASP ASN GLY CYS SER SEQRES 2 J 101 ARG CYS GLN GLN LYS LEU PHE PHE PHE LEU ARG ARG GLU SEQRES 3 J 101 GLY MET ARG GLN TYR GLY GLU CYS LEU HIS SER CYS PRO SEQRES 4 J 101 SER GLY TYR TYR GLY HIS ARG ALA PRO ASP MET ASN ARG SEQRES 5 J 101 CYS ALA ARG CYS ARG ILE GLU ASN CYS ASP SER CYS PHE SEQRES 6 J 101 SER LYS ASP PHE CYS THR LYS CYS LYS VAL GLY PHE TYR SEQRES 7 J 101 LEU HIS ARG GLY ARG CYS PHE ASP GLU CYS PRO ALA GLY SEQRES 8 J 101 PHE ALA PRO LEU ASP GLU THR MET GLU CYS HET CLR D 901 28 HET CLR H 301 28 HETNAM CLR CHOLESTEROL FORMUL 9 CLR 2(C27 H46 O) HELIX 1 AA1 PRO A 121 ARG A 126 1 6 HELIX 2 AA2 PRO A 169 ASN A 175 1 7 HELIX 3 AA3 PRO A 241 LEU A 247 5 7 HELIX 4 AA4 LYS A 381 GLN A 386 5 6 HELIX 5 AA5 TYR A 466 PHE A 473 1 8 HELIX 6 AA6 SER A 538 PHE A 555 1 18 HELIX 7 AA7 PHE A 555 PHE A 564 1 10 HELIX 8 AA8 PRO A 571 SER A 601 1 31 HELIX 9 AA9 ARG A 604 THR A 614 1 11 HELIX 10 AB1 SER A 616 ASP A 649 1 34 HELIX 11 AB2 GLN A 661 HIS A 683 1 23 HELIX 12 AB3 SER A 703 LEU A 732 1 30 HELIX 13 AB4 GLU A 739 SER A 741 5 3 HELIX 14 AB5 GLN A 742 PHE A 760 1 19 HELIX 15 AB6 PHE A 760 PHE A 768 1 9 HELIX 16 AB7 SER A 778 PHE A 790 1 13 HELIX 17 AB8 LEU A 796 ASN A 805 1 10 HELIX 18 AB9 ASN A 805 ARG A 818 1 14 HELIX 19 AC1 THR C 138 ARG C 149 1 12 HELIX 20 AC2 GLU C 163 GLN C 170 1 8 HELIX 21 AC3 ALA C 186 GLN C 198 1 13 HELIX 22 AC4 ASP C 218 CYS C 233 1 16 HELIX 23 AC5 CYS C 233 LYS C 243 1 11 HELIX 24 AC6 LYS E 511 THR E 515 5 5 HELIX 25 AC7 ASN E 533 PHE E 537 5 5 HELIX 26 AC8 PRO D 169 SER D 174 1 6 HELIX 27 AC9 PRO D 241 LEU D 247 5 7 HELIX 28 AD1 TYR D 466 CYS D 471 1 6 HELIX 29 AD2 ALA D 472 TRP D 474 5 3 HELIX 30 AD3 SER D 538 ALA D 552 1 15 HELIX 31 AD4 LEU D 553 PHE D 564 1 12 HELIX 32 AD5 PRO D 571 SER D 601 1 31 HELIX 33 AD6 PHE D 605 GLY D 615 1 11 HELIX 34 AD7 GLY D 617 LYS D 648 1 32 HELIX 35 AD8 HIS D 658 HIS D 683 1 26 HELIX 36 AD9 SER D 703 LYS D 727 1 25 HELIX 37 AE1 LYS D 727 LEU D 732 1 6 HELIX 38 AE2 SER D 743 PHE D 766 1 24 HELIX 39 AE3 SER D 778 PHE D 790 1 13 HELIX 40 AE4 CYS D 795 PHE D 804 1 10 HELIX 41 AE5 LYS D 807 THR D 820 1 14 HELIX 42 AE6 HIS H 102 LEU H 106 5 5 HELIX 43 AE7 THR H 138 GLY H 150 1 13 HELIX 44 AE8 GLU H 163 GLY H 171 1 9 HELIX 45 AE9 ALA H 186 GLN H 198 1 13 HELIX 46 AF1 TYR H 216 LYS H 243 1 28 SHEET 1 AA1 9 ARG A 40 ASP A 42 0 SHEET 2 AA1 9 ALA A 61 ILE A 64 1 O ASP A 63 N VAL A 41 SHEET 3 AA1 9 GLU A 85 LEU A 88 1 O GLN A 87 N ILE A 64 SHEET 4 AA1 9 VAL A 109 THR A 111 1 O THR A 111 N LEU A 86 SHEET 5 AA1 9 SER A 133 ARG A 135 1 O SER A 133 N LEU A 110 SHEET 6 AA1 9 HIS A 157 ASP A 162 1 O HIS A 157 N LEU A 134 SHEET 7 AA1 9 ALA A 181 LEU A 186 1 O LEU A 186 N ASP A 161 SHEET 8 AA1 9 VAL A 205 HIS A 207 1 O HIS A 207 N LEU A 184 SHEET 9 AA1 9 THR A 229 ASP A 231 1 O THR A 229 N LEU A 206 SHEET 1 AA2 2 SER A 191 ILE A 192 0 SHEET 2 AA2 2 SER A 215 LEU A 216 1 O SER A 215 N ILE A 192 SHEET 1 AA3 2 GLU A 252 GLY A 254 0 SHEET 2 AA3 2 THR A 276 HIS A 278 1 O HIS A 278 N LEU A 253 SHEET 1 AA4 6 SER A 300 ILE A 303 0 SHEET 2 AA4 6 SER A 323 LEU A 326 1 O THR A 325 N ILE A 303 SHEET 3 AA4 6 THR A 347 ASP A 349 1 O ASP A 349 N LEU A 324 SHEET 4 AA4 6 GLU A 369 SER A 371 1 O SER A 371 N LEU A 348 SHEET 5 AA4 6 ILE A 393 ASP A 395 1 O ILE A 393 N ILE A 370 SHEET 6 AA4 6 ASN A 417 ASP A 419 1 O ASP A 419 N LEU A 394 SHEET 1 AA5 2 GLN A 379 ILE A 380 0 SHEET 2 AA5 2 GLU A 403 ILE A 404 1 O GLU A 403 N ILE A 380 SHEET 1 AA6 3 GLN A 438 LYS A 440 0 SHEET 2 AA6 3 SER A 461 SER A 463 1 O SER A 461 N LEU A 439 SHEET 3 AA6 3 HIS A 521 CYS A 522 1 O HIS A 521 N LEU A 462 SHEET 1 AA7 8 THR C 58 LEU C 65 0 SHEET 2 AA7 8 TYR C 77 PHE C 85 -1 O GLY C 83 N ALA C 59 SHEET 3 AA7 8 VAL C 180 TYR C 182 -1 O TYR C 182 N ARG C 84 SHEET 4 AA7 8 VAL C 154 ASP C 157 1 N PHE C 156 O VAL C 181 SHEET 5 AA7 8 TRP C 120 LYS C 125 1 N GLY C 122 O ILE C 155 SHEET 6 AA7 8 ALA C 94 GLN C 100 1 N VAL C 99 O VAL C 121 SHEET 7 AA7 8 ARG C 202 ILE C 205 -1 O ILE C 205 N ALA C 94 SHEET 8 AA7 8 THR C 58 LEU C 65 -1 N GLU C 62 O ARG C 204 SHEET 1 AA8 4 VAL E 24 GLU E 25 0 SHEET 2 AA8 4 ARG E 444 ALA E 448 -1 O ALA E 448 N VAL E 24 SHEET 3 AA8 4 THR E 502 GLN E 506 -1 O LEU E 505 N LEU E 445 SHEET 4 AA8 4 THR E 493 ASP E 497 -1 N SER E 495 O TYR E 504 SHEET 1 AA9 5 THR E 482 TYR E 484 0 SHEET 2 AA9 5 ARG E 470 VAL E 476 -1 N THR E 475 O ILE E 483 SHEET 3 AA9 5 TYR E 457 GLN E 464 -1 N MET E 459 O VAL E 476 SHEET 4 AA9 5 ALA E 516 ARG E 523 -1 O TYR E 519 N PHE E 462 SHEET 5 AA9 5 TYR E 539 TRP E 540 -1 O TYR E 539 N SER E 522 SHEET 1 AB1 5 THR E 482 TYR E 484 0 SHEET 2 AB1 5 ARG E 470 VAL E 476 -1 N THR E 475 O ILE E 483 SHEET 3 AB1 5 TYR E 457 GLN E 464 -1 N MET E 459 O VAL E 476 SHEET 4 AB1 5 ALA E 516 ARG E 523 -1 O TYR E 519 N PHE E 462 SHEET 5 AB1 5 THR E 544 VAL E 546 -1 O VAL E 546 N ALA E 516 SHEET 1 AB2 4 GLN G 70 LEU G 75 0 SHEET 2 AB2 4 PHE G 60 ARG G 65 -1 N PHE G 60 O LEU G 75 SHEET 3 AB2 4 ASN G 91 ARG G 95 1 O CYS G 93 N PHE G 61 SHEET 4 AB2 4 TYR G 82 HIS G 85 -1 N TYR G 83 O ALA G 94 SHEET 1 AB3 2 CYS G 101 CYS G 104 0 SHEET 2 AB3 2 CYS G 110 CYS G 113 -1 O LYS G 112 N SER G 103 SHEET 1 AB4 6 SER D 34 CYS D 35 0 SHEET 2 AB4 6 ARG D 40 ASP D 42 -1 O ASP D 42 N SER D 34 SHEET 3 AB4 6 ALA D 61 ASP D 63 1 O ALA D 61 N VAL D 41 SHEET 4 AB4 6 GLU D 85 GLN D 87 1 O GLN D 87 N LEU D 62 SHEET 5 AB4 6 VAL D 109 THR D 111 1 O THR D 111 N LEU D 86 SHEET 6 AB4 6 SER D 133 ARG D 135 1 O SER D 133 N LEU D 110 SHEET 1 AB5 2 GLN D 71 LEU D 72 0 SHEET 2 AB5 2 PHE D 95 ILE D 96 1 O PHE D 95 N LEU D 72 SHEET 1 AB6 3 ALA D 181 THR D 183 0 SHEET 2 AB6 3 VAL D 205 HIS D 207 1 O VAL D 205 N LEU D 182 SHEET 3 AB6 3 THR D 229 ASP D 231 1 O THR D 229 N LEU D 206 SHEET 1 AB7 2 SER D 191 ILE D 192 0 SHEET 2 AB7 2 SER D 215 LEU D 216 1 O SER D 215 N ILE D 192 SHEET 1 AB8 2 GLU D 252 GLY D 254 0 SHEET 2 AB8 2 THR D 276 HIS D 278 1 O HIS D 278 N LEU D 253 SHEET 1 AB9 9 LEU D 301 ILE D 303 0 SHEET 2 AB9 9 LEU D 324 LEU D 326 1 O THR D 325 N LEU D 301 SHEET 3 AB9 9 LEU D 348 ASP D 349 1 O ASP D 349 N LEU D 324 SHEET 4 AB9 9 GLU D 369 SER D 371 1 O GLU D 369 N LEU D 348 SHEET 5 AB9 9 ILE D 393 ASP D 395 1 O ASP D 395 N ILE D 370 SHEET 6 AB9 9 ASN D 417 ASP D 419 1 O ASP D 419 N LEU D 394 SHEET 7 AB9 9 GLN D 438 LYS D 440 1 O GLN D 438 N LEU D 418 SHEET 8 AB9 9 SER D 461 SER D 463 1 O SER D 463 N LEU D 439 SHEET 9 AB9 9 HIS D 521 CYS D 522 1 O HIS D 521 N LEU D 462 SHEET 1 AC1 8 THR H 58 LEU H 65 0 SHEET 2 AC1 8 TYR H 77 PHE H 85 -1 O GLY H 83 N ALA H 59 SHEET 3 AC1 8 VAL H 180 TYR H 182 -1 O TYR H 182 N ARG H 84 SHEET 4 AC1 8 ALA H 153 ASP H 157 1 N PHE H 156 O VAL H 181 SHEET 5 AC1 8 TRP H 120 LYS H 125 1 N GLY H 122 O ILE H 155 SHEET 6 AC1 8 ALA H 94 GLN H 100 1 N VAL H 99 O VAL H 121 SHEET 7 AC1 8 ARG H 202 GLN H 206 -1 O ILE H 205 N ALA H 94 SHEET 8 AC1 8 THR H 58 LEU H 65 -1 N PHE H 60 O GLN H 206 SHEET 1 AC2 4 LEU I 23 SER I 26 0 SHEET 2 AC2 4 LEU I 443 ALA I 449 -1 O SER I 446 N SER I 26 SHEET 3 AC2 4 THR I 502 MET I 507 -1 O LEU I 505 N LEU I 445 SHEET 4 AC2 4 PHE I 492 ASP I 497 -1 N SER I 495 O TYR I 504 SHEET 1 AC3 5 THR I 482 TYR I 484 0 SHEET 2 AC3 5 ARG I 470 VAL I 476 -1 N THR I 475 O ILE I 483 SHEET 3 AC3 5 TYR I 457 GLN I 464 -1 N TRP I 461 O ALA I 474 SHEET 4 AC3 5 ALA I 516 ARG I 523 -1 O TYR I 519 N PHE I 462 SHEET 5 AC3 5 TYR I 539 TRP I 540 -1 O TYR I 539 N SER I 522 SHEET 1 AC4 5 THR I 482 TYR I 484 0 SHEET 2 AC4 5 ARG I 470 VAL I 476 -1 N THR I 475 O ILE I 483 SHEET 3 AC4 5 TYR I 457 GLN I 464 -1 N TRP I 461 O ALA I 474 SHEET 4 AC4 5 ALA I 516 ARG I 523 -1 O TYR I 519 N PHE I 462 SHEET 5 AC4 5 THR I 544 VAL I 546 -1 O VAL I 546 N ALA I 516 SHEET 1 AC5 2 PHE J 60 ARG J 65 0 SHEET 2 AC5 2 GLN J 70 LEU J 75 -1 O LEU J 75 N PHE J 60 SHEET 1 AC6 2 TYR J 82 HIS J 85 0 SHEET 2 AC6 2 ARG J 92 ARG J 95 -1 O ALA J 94 N TYR J 83 SHEET 1 AC7 2 CYS J 101 SER J 106 0 SHEET 2 AC7 2 PHE J 109 CYS J 113 -1 O PHE J 109 N PHE J 105 SSBOND 1 CYS A 33 CYS A 43 1555 1555 2.03 SSBOND 2 CYS A 339 CYS A 364 1555 1555 2.03 SSBOND 3 CYS A 618 CYS A 693 1555 1555 2.03 SSBOND 4 CYS A 757 CYS A 761 1555 1555 2.03 SSBOND 5 CYS E 447 CYS E 520 1555 1555 2.03 SSBOND 6 CYS G 43 CYS G 74 1555 1555 2.03 SSBOND 7 CYS G 46 CYS G 52 1555 1555 2.04 SSBOND 8 CYS G 55 CYS G 74 1555 1555 2.03 SSBOND 9 CYS G 78 CYS G 93 1555 1555 2.03 SSBOND 10 CYS G 101 CYS G 110 1555 1555 2.03 SSBOND 11 CYS G 113 CYS G 124 1555 1555 2.03 SSBOND 12 CYS G 128 CYS G 141 1555 1555 2.03 SSBOND 13 CYS D 33 CYS D 43 1555 1555 2.03 SSBOND 14 CYS D 339 CYS D 364 1555 1555 2.03 SSBOND 15 CYS D 618 CYS D 693 1555 1555 2.03 SSBOND 16 CYS H 107 CYS H 136 1555 1555 2.03 SSBOND 17 CYS J 46 CYS J 52 1555 1555 2.04 SSBOND 18 CYS J 55 CYS J 74 1555 1555 2.03 SSBOND 19 CYS J 78 CYS J 93 1555 1555 2.03 SSBOND 20 CYS J 101 CYS J 110 1555 1555 2.03 SSBOND 21 CYS J 113 CYS J 124 1555 1555 2.03 SSBOND 22 CYS J 128 CYS J 141 1555 1555 2.03 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000