HEADER PROTEIN BINDING 16-FEB-24 8YBZ TITLE STATE - II: SPIKE 3-UP RBD WITH THSC20.HVTR26 (FAB26) COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: THSC20.HVTR26 (FAB26) - HEAVY CHAIN; COMPND 8 CHAIN: F, E, D; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: THSC20.HVTR26 (FAB26) - LIGHT CHAIN; COMPND 12 CHAIN: I, H, G; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; SOURCE 3 ORGANISM_TAXID: 2901879; SOURCE 4 STRAIN: WUHAN; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: EXPI293T; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 14 MOL_ID: 3; SOURCE 15 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 16 ORGANISM_TAXID: 9606; SOURCE 17 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 18 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS CRYO-EM ANALYSIS, SPIKE PROTEIN, MONOCLONAL ANTIBODY, PROTEIN BINDING EXPDTA ELECTRON MICROSCOPY AUTHOR C.F.RENCILIN,J.BHATTACHARYA,S.DUTTA REVDAT 1 19-FEB-25 8YBZ 0 JRNL AUTH C.F.RENCILIN,J.BHATTACHARYA,S.DUTTA JRNL TITL CRYO-EM STRUCTURES OF TWO BROADLY SARS-COV-2 NEUTRALIZING JRNL TITL 2 MONOCLONAL ANTIBODIES ISOLATED FROM A SINGLE INDIVIDUAL THAT JRNL TITL 3 DIFFER IN THEIR TARGET SPECIFICITIES JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 4.80 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.800 REMARK 3 NUMBER OF PARTICLES : 48584 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8YBZ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 19-FEB-24. REMARK 100 THE DEPOSITION ID IS D_1300045370. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : STATE - II: SPIKE 3-UP RBD WITH REMARK 245 THSC20.HVTR26 (FAB26) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TALOS ARCTICA REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2750.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, F, I, E, H, D, G REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 PHE A 2 REMARK 465 VAL A 3 REMARK 465 PHE A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 PRO A 9 REMARK 465 LEU A 10 REMARK 465 VAL A 11 REMARK 465 SER A 12 REMARK 465 SER A 13 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 618 REMARK 465 GLU A 619 REMARK 465 VAL A 620 REMARK 465 PRO A 621 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 SER A 640 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 ASN A 679 REMARK 465 SER A 680 REMARK 465 PRO A 681 REMARK 465 ARG A 682 REMARK 465 ARG A 683 REMARK 465 ALA A 684 REMARK 465 ARG A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 THR A 941 REMARK 465 ALA A 942 REMARK 465 SER A 943 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 TYR A 1209 REMARK 465 ILE A 1210 REMARK 465 LYS A 1211 REMARK 465 TRP A 1212 REMARK 465 PRO A 1213 REMARK 465 TRP A 1214 REMARK 465 TYR A 1215 REMARK 465 ILE A 1216 REMARK 465 TRP A 1217 REMARK 465 LEU A 1218 REMARK 465 GLY A 1219 REMARK 465 PHE A 1220 REMARK 465 ILE A 1221 REMARK 465 ALA A 1222 REMARK 465 GLY A 1223 REMARK 465 LEU A 1224 REMARK 465 ILE A 1225 REMARK 465 ALA A 1226 REMARK 465 ILE A 1227 REMARK 465 VAL A 1228 REMARK 465 MET A 1229 REMARK 465 VAL A 1230 REMARK 465 THR A 1231 REMARK 465 ILE A 1232 REMARK 465 MET A 1233 REMARK 465 LEU A 1234 REMARK 465 CYS A 1235 REMARK 465 CYS A 1236 REMARK 465 MET A 1237 REMARK 465 THR A 1238 REMARK 465 SER A 1239 REMARK 465 CYS A 1240 REMARK 465 CYS A 1241 REMARK 465 SER A 1242 REMARK 465 CYS A 1243 REMARK 465 LEU A 1244 REMARK 465 LYS A 1245 REMARK 465 GLY A 1246 REMARK 465 CYS A 1247 REMARK 465 CYS A 1248 REMARK 465 SER A 1249 REMARK 465 CYS A 1250 REMARK 465 GLY A 1251 REMARK 465 SER A 1252 REMARK 465 CYS A 1253 REMARK 465 CYS A 1254 REMARK 465 LYS A 1255 REMARK 465 PHE A 1256 REMARK 465 ASP A 1257 REMARK 465 GLU A 1258 REMARK 465 ASP A 1259 REMARK 465 ASP A 1260 REMARK 465 SER A 1261 REMARK 465 GLU A 1262 REMARK 465 PRO A 1263 REMARK 465 VAL A 1264 REMARK 465 LEU A 1265 REMARK 465 LYS A 1266 REMARK 465 GLY A 1267 REMARK 465 VAL A 1268 REMARK 465 LYS A 1269 REMARK 465 LEU A 1270 REMARK 465 HIS A 1271 REMARK 465 TYR A 1272 REMARK 465 THR A 1273 REMARK 465 MET B 1 REMARK 465 PHE B 2 REMARK 465 VAL B 3 REMARK 465 PHE B 4 REMARK 465 LEU B 5 REMARK 465 VAL B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 PRO B 9 REMARK 465 LEU B 10 REMARK 465 VAL B 11 REMARK 465 SER B 12 REMARK 465 SER B 13 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 THR B 618 REMARK 465 GLU B 619 REMARK 465 VAL B 620 REMARK 465 PRO B 621 REMARK 465 VAL B 622 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 TYR B 636 REMARK 465 SER B 637 REMARK 465 THR B 638 REMARK 465 GLY B 639 REMARK 465 SER B 640 REMARK 465 GLN B 677 REMARK 465 THR B 678 REMARK 465 ASN B 679 REMARK 465 SER B 680 REMARK 465 PRO B 681 REMARK 465 ARG B 682 REMARK 465 ARG B 683 REMARK 465 ALA B 684 REMARK 465 ARG B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 THR B 941 REMARK 465 ALA B 942 REMARK 465 SER B 943 REMARK 465 SER B 1147 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 TYR B 1209 REMARK 465 ILE B 1210 REMARK 465 LYS B 1211 REMARK 465 TRP B 1212 REMARK 465 PRO B 1213 REMARK 465 TRP B 1214 REMARK 465 TYR B 1215 REMARK 465 ILE B 1216 REMARK 465 TRP B 1217 REMARK 465 LEU B 1218 REMARK 465 GLY B 1219 REMARK 465 PHE B 1220 REMARK 465 ILE B 1221 REMARK 465 ALA B 1222 REMARK 465 GLY B 1223 REMARK 465 LEU B 1224 REMARK 465 ILE B 1225 REMARK 465 ALA B 1226 REMARK 465 ILE B 1227 REMARK 465 VAL B 1228 REMARK 465 MET B 1229 REMARK 465 VAL B 1230 REMARK 465 THR B 1231 REMARK 465 ILE B 1232 REMARK 465 MET B 1233 REMARK 465 LEU B 1234 REMARK 465 CYS B 1235 REMARK 465 CYS B 1236 REMARK 465 MET B 1237 REMARK 465 THR B 1238 REMARK 465 SER B 1239 REMARK 465 CYS B 1240 REMARK 465 CYS B 1241 REMARK 465 SER B 1242 REMARK 465 CYS B 1243 REMARK 465 LEU B 1244 REMARK 465 LYS B 1245 REMARK 465 GLY B 1246 REMARK 465 CYS B 1247 REMARK 465 CYS B 1248 REMARK 465 SER B 1249 REMARK 465 CYS B 1250 REMARK 465 GLY B 1251 REMARK 465 SER B 1252 REMARK 465 CYS B 1253 REMARK 465 CYS B 1254 REMARK 465 LYS B 1255 REMARK 465 PHE B 1256 REMARK 465 ASP B 1257 REMARK 465 GLU B 1258 REMARK 465 ASP B 1259 REMARK 465 ASP B 1260 REMARK 465 SER B 1261 REMARK 465 GLU B 1262 REMARK 465 PRO B 1263 REMARK 465 VAL B 1264 REMARK 465 LEU B 1265 REMARK 465 LYS B 1266 REMARK 465 GLY B 1267 REMARK 465 VAL B 1268 REMARK 465 LYS B 1269 REMARK 465 LEU B 1270 REMARK 465 HIS B 1271 REMARK 465 TYR B 1272 REMARK 465 THR B 1273 REMARK 465 MET C 1 REMARK 465 PHE C 2 REMARK 465 VAL C 3 REMARK 465 PHE C 4 REMARK 465 LEU C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 PRO C 9 REMARK 465 LEU C 10 REMARK 465 VAL C 11 REMARK 465 SER C 12 REMARK 465 SER C 13 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 618 REMARK 465 GLU C 619 REMARK 465 VAL C 620 REMARK 465 PRO C 621 REMARK 465 VAL C 622 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 THR C 638 REMARK 465 GLY C 639 REMARK 465 SER C 640 REMARK 465 GLN C 677 REMARK 465 THR C 678 REMARK 465 ASN C 679 REMARK 465 SER C 680 REMARK 465 PRO C 681 REMARK 465 ARG C 682 REMARK 465 ARG C 683 REMARK 465 ALA C 684 REMARK 465 ARG C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 THR C 941 REMARK 465 ALA C 942 REMARK 465 SER C 943 REMARK 465 SER C 1147 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 TYR C 1209 REMARK 465 ILE C 1210 REMARK 465 LYS C 1211 REMARK 465 TRP C 1212 REMARK 465 PRO C 1213 REMARK 465 TRP C 1214 REMARK 465 TYR C 1215 REMARK 465 ILE C 1216 REMARK 465 TRP C 1217 REMARK 465 LEU C 1218 REMARK 465 GLY C 1219 REMARK 465 PHE C 1220 REMARK 465 ILE C 1221 REMARK 465 ALA C 1222 REMARK 465 GLY C 1223 REMARK 465 LEU C 1224 REMARK 465 ILE C 1225 REMARK 465 ALA C 1226 REMARK 465 ILE C 1227 REMARK 465 VAL C 1228 REMARK 465 MET C 1229 REMARK 465 VAL C 1230 REMARK 465 THR C 1231 REMARK 465 ILE C 1232 REMARK 465 MET C 1233 REMARK 465 LEU C 1234 REMARK 465 CYS C 1235 REMARK 465 CYS C 1236 REMARK 465 MET C 1237 REMARK 465 THR C 1238 REMARK 465 SER C 1239 REMARK 465 CYS C 1240 REMARK 465 CYS C 1241 REMARK 465 SER C 1242 REMARK 465 CYS C 1243 REMARK 465 LEU C 1244 REMARK 465 LYS C 1245 REMARK 465 GLY C 1246 REMARK 465 CYS C 1247 REMARK 465 CYS C 1248 REMARK 465 SER C 1249 REMARK 465 CYS C 1250 REMARK 465 GLY C 1251 REMARK 465 SER C 1252 REMARK 465 CYS C 1253 REMARK 465 CYS C 1254 REMARK 465 LYS C 1255 REMARK 465 PHE C 1256 REMARK 465 ASP C 1257 REMARK 465 GLU C 1258 REMARK 465 ASP C 1259 REMARK 465 ASP C 1260 REMARK 465 SER C 1261 REMARK 465 GLU C 1262 REMARK 465 PRO C 1263 REMARK 465 VAL C 1264 REMARK 465 LEU C 1265 REMARK 465 LYS C 1266 REMARK 465 GLY C 1267 REMARK 465 VAL C 1268 REMARK 465 LYS C 1269 REMARK 465 LEU C 1270 REMARK 465 HIS C 1271 REMARK 465 TYR C 1272 REMARK 465 THR C 1273 REMARK 465 ASP F 231 REMARK 465 SER I 216 REMARK 465 ASP E 231 REMARK 465 SER H 216 REMARK 465 ASP D 231 REMARK 465 SER G 216 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 NE2 GLN A 787 OD1 ASN C 703 2.00 REMARK 500 NZ LYS A 386 O ARG B 983 2.05 REMARK 500 OH TYR C 489 OE1 GLN C 493 2.07 REMARK 500 OH TYR A 489 OE1 GLN A 493 2.07 REMARK 500 OH TYR B 489 OE1 GLN B 493 2.07 REMARK 500 N GLN B 474 O GLY H 30 2.10 REMARK 500 O ARG A 983 NZ LYS C 386 2.11 REMARK 500 NZ LYS B 557 O ASN C 282 2.11 REMARK 500 O GLY B 381 NH2 ARG C 983 2.16 REMARK 500 OG1 THR B 1076 OG SER B 1097 2.16 REMARK 500 O ASP E 61 OH TYR H 2 2.16 REMARK 500 OG1 THR A 1076 OG SER A 1097 2.16 REMARK 500 OG1 THR C 1076 OG SER C 1097 2.16 REMARK 500 OG1 THR B 912 OD1 ASN B 914 2.17 REMARK 500 OG1 THR C 912 OD1 ASN C 914 2.17 REMARK 500 OG1 THR A 912 OD1 ASN A 914 2.17 REMARK 500 OG1 THR B 415 OD2 ASP B 420 2.19 REMARK 500 O GLY I 95 OG1 THR I 98 2.19 REMARK 500 O GLY G 95 OG1 THR G 98 2.19 REMARK 500 OG1 THR A 415 OD2 ASP A 420 2.19 REMARK 500 OG1 THR C 415 OD2 ASP C 420 2.19 REMARK 500 O GLY H 95 OG1 THR H 98 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PRO A 85 CA - N - CD ANGL. DEV. = -8.9 DEGREES REMARK 500 PRO B 85 CA - N - CD ANGL. DEV. = -8.8 DEGREES REMARK 500 PRO C 85 CA - N - CD ANGL. DEV. = -8.9 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 81 77.39 -152.25 REMARK 500 ARG A 158 58.21 -99.34 REMARK 500 VAL A 159 -61.28 -101.00 REMARK 500 ASP A 198 18.74 53.70 REMARK 500 ASN A 211 85.52 -150.33 REMARK 500 ASP A 215 150.26 -45.55 REMARK 500 LEU A 226 -61.92 -94.24 REMARK 500 PRO A 230 47.82 -82.68 REMARK 500 ALA A 262 119.09 -160.72 REMARK 500 LEU A 293 -37.82 -135.76 REMARK 500 ALA A 344 -67.65 -93.24 REMARK 500 THR A 345 -41.10 -135.37 REMARK 500 ARG A 346 140.75 -174.48 REMARK 500 GLN A 474 15.48 -140.04 REMARK 500 ALA A 475 -87.74 105.50 REMARK 500 THR A 478 78.85 63.98 REMARK 500 ASN A 481 -9.98 78.22 REMARK 500 VAL A 483 38.27 -143.99 REMARK 500 GLU A 484 71.63 75.02 REMARK 500 ASN A 487 40.63 73.72 REMARK 500 THR A 523 16.44 -143.46 REMARK 500 PRO A 561 41.46 -79.51 REMARK 500 PHE A 562 15.64 -142.95 REMARK 500 GLN A 613 -63.98 -98.37 REMARK 500 VAL A 729 -55.80 -124.82 REMARK 500 PHE A 782 52.40 -91.20 REMARK 500 LEU A 858 57.27 -90.11 REMARK 500 ASP A1041 12.86 58.63 REMARK 500 SER A1123 29.76 -140.08 REMARK 500 ASN B 81 77.45 -152.26 REMARK 500 ARG B 158 58.26 -99.36 REMARK 500 VAL B 159 -61.35 -101.00 REMARK 500 ASP B 198 18.67 53.78 REMARK 500 ASN B 211 85.54 -150.37 REMARK 500 ASP B 215 150.28 -45.55 REMARK 500 LEU B 226 -61.85 -94.25 REMARK 500 PRO B 230 47.87 -82.67 REMARK 500 ALA B 262 119.10 -160.70 REMARK 500 LEU B 293 -37.85 -135.77 REMARK 500 ALA B 344 -67.73 -93.31 REMARK 500 THR B 345 -41.08 -135.33 REMARK 500 ARG B 346 140.80 -174.41 REMARK 500 GLN B 474 15.55 -140.05 REMARK 500 ALA B 475 -87.80 105.41 REMARK 500 THR B 478 78.82 63.95 REMARK 500 ASN B 481 -10.03 78.25 REMARK 500 VAL B 483 38.34 -143.97 REMARK 500 GLU B 484 71.74 74.96 REMARK 500 ASN B 487 40.63 73.69 REMARK 500 THR B 523 16.53 -143.52 REMARK 500 REMARK 500 THIS ENTRY HAS 112 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 ASN A 481 GLY A 482 145.72 REMARK 500 CYS A 525 GLY A 526 -138.37 REMARK 500 ASN B 481 GLY B 482 145.73 REMARK 500 CYS B 525 GLY B 526 -138.45 REMARK 500 ASN C 481 GLY C 482 145.70 REMARK 500 CYS C 525 GLY C 526 -138.41 REMARK 500 GLU I 52 VAL I 53 -145.27 REMARK 500 SER I 74 LEU I 75 140.09 REMARK 500 GLU H 52 VAL H 53 -145.22 REMARK 500 SER H 74 LEU H 75 140.05 REMARK 500 GLU G 52 VAL G 53 -145.27 REMARK 500 SER G 74 LEU G 75 140.08 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-34603 RELATED DB: EMDB DBREF 8YBZ A 1 1273 UNP P0DTC2 SPIKE_SARS2 1 1273 DBREF 8YBZ B 1 1273 UNP P0DTC2 SPIKE_SARS2 1 1273 DBREF 8YBZ C 1 1273 UNP P0DTC2 SPIKE_SARS2 1 1273 DBREF 8YBZ F 1 231 PDB 8YBZ 8YBZ 1 231 DBREF 8YBZ I 1 216 PDB 8YBZ 8YBZ 1 216 DBREF 8YBZ E 1 231 PDB 8YBZ 8YBZ 1 231 DBREF 8YBZ H 1 216 PDB 8YBZ 8YBZ 1 216 DBREF 8YBZ D 1 231 PDB 8YBZ 8YBZ 1 231 DBREF 8YBZ G 1 216 PDB 8YBZ 8YBZ 1 216 SEQADV 8YBZ PRO A 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 8YBZ PRO A 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 8YBZ PRO B 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 8YBZ PRO B 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 8YBZ PRO C 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 8YBZ PRO C 987 UNP P0DTC2 VAL 987 CONFLICT SEQRES 1 A 1273 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 A 1273 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 A 1273 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 A 1273 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 A 1273 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 A 1273 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 A 1273 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 A 1273 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 A 1273 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 A 1273 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 A 1273 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 A 1273 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 A 1273 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 A 1273 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 A 1273 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 A 1273 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 A 1273 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 A 1273 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 A 1273 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 A 1273 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 A 1273 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 A 1273 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 A 1273 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 A 1273 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 A 1273 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 A 1273 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 A 1273 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 A 1273 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 A 1273 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 A 1273 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 A 1273 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 A 1273 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 A 1273 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 A 1273 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 A 1273 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 A 1273 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 A 1273 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 A 1273 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 A 1273 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 A 1273 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 A 1273 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 A 1273 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 A 1273 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 A 1273 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 A 1273 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 A 1273 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 A 1273 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 A 1273 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 A 1273 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 A 1273 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 A 1273 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 A 1273 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 A 1273 GLN THR ASN SER PRO ARG ARG ALA ARG SER VAL ALA SER SEQRES 54 A 1273 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 A 1273 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 A 1273 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 A 1273 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 A 1273 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 A 1273 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 60 A 1273 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 A 1273 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 A 1273 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 A 1273 PRO ASP PRO SER LYS PRO SER LYS ARG SER PHE ILE GLU SEQRES 64 A 1273 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 A 1273 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 A 1273 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 A 1273 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 A 1273 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 A 1273 GLY TRP THR PHE GLY ALA GLY ALA ALA LEU GLN ILE PRO SEQRES 70 A 1273 PHE ALA MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 A 1273 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 A 1273 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 A 1273 SER LEU SER SER THR ALA SER ALA LEU GLY LYS LEU GLN SEQRES 74 A 1273 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 A 1273 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 76 A 1273 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 A 1273 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 A 1273 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 A 1273 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 A 1273 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 A 1273 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 A 1273 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 A 1273 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 A 1273 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 A 1273 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 A 1273 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 A 1273 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 A 1273 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 89 A 1273 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 90 A 1273 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 91 A 1273 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 92 A 1273 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 93 A 1273 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR SEQRES 94 A 1273 ILE LYS TRP PRO TRP TYR ILE TRP LEU GLY PHE ILE ALA SEQRES 95 A 1273 GLY LEU ILE ALA ILE VAL MET VAL THR ILE MET LEU CYS SEQRES 96 A 1273 CYS MET THR SER CYS CYS SER CYS LEU LYS GLY CYS CYS SEQRES 97 A 1273 SER CYS GLY SER CYS CYS LYS PHE ASP GLU ASP ASP SER SEQRES 98 A 1273 GLU PRO VAL LEU LYS GLY VAL LYS LEU HIS TYR THR SEQRES 1 B 1273 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 B 1273 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 B 1273 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 B 1273 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 B 1273 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 B 1273 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 B 1273 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 B 1273 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 B 1273 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 B 1273 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 B 1273 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 B 1273 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 B 1273 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 B 1273 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 B 1273 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 B 1273 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 B 1273 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 B 1273 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 B 1273 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 B 1273 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 B 1273 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 B 1273 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 B 1273 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 B 1273 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 B 1273 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 B 1273 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 B 1273 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 B 1273 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 B 1273 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 B 1273 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 B 1273 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 B 1273 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 B 1273 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 B 1273 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 B 1273 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 B 1273 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 B 1273 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 B 1273 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 B 1273 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 B 1273 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 B 1273 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 B 1273 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 B 1273 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 B 1273 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 B 1273 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 B 1273 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 B 1273 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 B 1273 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 B 1273 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 B 1273 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 B 1273 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 B 1273 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 B 1273 GLN THR ASN SER PRO ARG ARG ALA ARG SER VAL ALA SER SEQRES 54 B 1273 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 B 1273 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 B 1273 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 B 1273 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 B 1273 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 B 1273 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 60 B 1273 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 B 1273 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 B 1273 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 B 1273 PRO ASP PRO SER LYS PRO SER LYS ARG SER PHE ILE GLU SEQRES 64 B 1273 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 B 1273 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 B 1273 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 B 1273 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 B 1273 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 B 1273 GLY TRP THR PHE GLY ALA GLY ALA ALA LEU GLN ILE PRO SEQRES 70 B 1273 PHE ALA MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 B 1273 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 B 1273 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 B 1273 SER LEU SER SER THR ALA SER ALA LEU GLY LYS LEU GLN SEQRES 74 B 1273 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 B 1273 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 76 B 1273 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 B 1273 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 B 1273 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 B 1273 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 B 1273 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 B 1273 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 B 1273 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 B 1273 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 B 1273 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 B 1273 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 B 1273 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 B 1273 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 B 1273 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 89 B 1273 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 90 B 1273 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 91 B 1273 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 92 B 1273 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 93 B 1273 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR SEQRES 94 B 1273 ILE LYS TRP PRO TRP TYR ILE TRP LEU GLY PHE ILE ALA SEQRES 95 B 1273 GLY LEU ILE ALA ILE VAL MET VAL THR ILE MET LEU CYS SEQRES 96 B 1273 CYS MET THR SER CYS CYS SER CYS LEU LYS GLY CYS CYS SEQRES 97 B 1273 SER CYS GLY SER CYS CYS LYS PHE ASP GLU ASP ASP SER SEQRES 98 B 1273 GLU PRO VAL LEU LYS GLY VAL LYS LEU HIS TYR THR SEQRES 1 C 1273 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 C 1273 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 C 1273 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 C 1273 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 C 1273 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 C 1273 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 C 1273 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 C 1273 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 C 1273 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 C 1273 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 C 1273 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 C 1273 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 C 1273 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 C 1273 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 C 1273 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 C 1273 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 C 1273 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 C 1273 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 C 1273 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 C 1273 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 C 1273 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 C 1273 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 C 1273 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 C 1273 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 C 1273 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 C 1273 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 C 1273 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 C 1273 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 C 1273 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 C 1273 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 C 1273 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 C 1273 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 C 1273 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 C 1273 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 C 1273 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 C 1273 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 C 1273 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 C 1273 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 C 1273 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 C 1273 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 C 1273 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 C 1273 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 C 1273 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 C 1273 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 C 1273 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 C 1273 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 C 1273 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 C 1273 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 C 1273 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 C 1273 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 C 1273 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 C 1273 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 C 1273 GLN THR ASN SER PRO ARG ARG ALA ARG SER VAL ALA SER SEQRES 54 C 1273 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 C 1273 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 C 1273 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 C 1273 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 C 1273 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 C 1273 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 60 C 1273 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 C 1273 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 C 1273 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 C 1273 PRO ASP PRO SER LYS PRO SER LYS ARG SER PHE ILE GLU SEQRES 64 C 1273 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 C 1273 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 C 1273 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 C 1273 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 C 1273 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 C 1273 GLY TRP THR PHE GLY ALA GLY ALA ALA LEU GLN ILE PRO SEQRES 70 C 1273 PHE ALA MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 C 1273 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 C 1273 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 C 1273 SER LEU SER SER THR ALA SER ALA LEU GLY LYS LEU GLN SEQRES 74 C 1273 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 C 1273 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 76 C 1273 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 C 1273 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 C 1273 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 C 1273 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 C 1273 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 C 1273 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 C 1273 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 C 1273 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 C 1273 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 C 1273 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 C 1273 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 C 1273 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 C 1273 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 89 C 1273 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 90 C 1273 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 91 C 1273 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 92 C 1273 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 93 C 1273 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR SEQRES 94 C 1273 ILE LYS TRP PRO TRP TYR ILE TRP LEU GLY PHE ILE ALA SEQRES 95 C 1273 GLY LEU ILE ALA ILE VAL MET VAL THR ILE MET LEU CYS SEQRES 96 C 1273 CYS MET THR SER CYS CYS SER CYS LEU LYS GLY CYS CYS SEQRES 97 C 1273 SER CYS GLY SER CYS CYS LYS PHE ASP GLU ASP ASP SER SEQRES 98 C 1273 GLU PRO VAL LEU LYS GLY VAL LYS LEU HIS TYR THR SEQRES 1 F 231 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 F 231 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 F 231 PHE THR VAL SER SER ASN TYR MET SER TRP VAL ARG GLN SEQRES 4 F 231 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER ALA ILE TYR SEQRES 5 F 231 SER GLY ASP SER THR TYR TYR ALA ASP SER VAL LYS GLY SEQRES 6 F 231 ARG PHE THR ILE SER ARG HIS ASN PRO LYS ASN THR LEU SEQRES 7 F 231 TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA SEQRES 8 F 231 VAL TYR TYR CYS ALA ARG LEU VAL GLY ALA LEU THR ASN SEQRES 9 F 231 ILE VAL VAL SER GLY ASP GLY GLY ALA PHE ASP ILE TRP SEQRES 10 F 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 F 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 F 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 F 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 F 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 F 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 F 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 F 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 F 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 I 216 SER TYR GLU LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 I 216 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 I 216 SER ASP VAL GLY SER TYR ASN LEU VAL SER TRP TYR GLN SEQRES 4 I 216 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR GLU SEQRES 5 I 216 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 I 216 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 I 216 GLY LEU GLN ALA GLU ASP GLU VAL ASP TYR TYR CYS CYS SEQRES 8 I 216 SER TYR ALA GLY SER SER THR TRP VAL PHE GLY GLY GLY SEQRES 9 I 216 THR LYS LEU THR VAL LEU SER GLN PRO LYS ALA ALA PRO SEQRES 10 I 216 SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11 I 216 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12 I 216 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SEQRES 13 I 216 SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER SEQRES 14 I 216 LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SEQRES 15 I 216 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16 I 216 SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS SEQRES 17 I 216 THR VAL ALA PRO THR GLU CYS SER SEQRES 1 E 231 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 E 231 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 E 231 PHE THR VAL SER SER ASN TYR MET SER TRP VAL ARG GLN SEQRES 4 E 231 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER ALA ILE TYR SEQRES 5 E 231 SER GLY ASP SER THR TYR TYR ALA ASP SER VAL LYS GLY SEQRES 6 E 231 ARG PHE THR ILE SER ARG HIS ASN PRO LYS ASN THR LEU SEQRES 7 E 231 TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA SEQRES 8 E 231 VAL TYR TYR CYS ALA ARG LEU VAL GLY ALA LEU THR ASN SEQRES 9 E 231 ILE VAL VAL SER GLY ASP GLY GLY ALA PHE ASP ILE TRP SEQRES 10 E 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 E 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 E 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 E 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 E 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 E 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 E 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 E 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 E 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 H 216 SER TYR GLU LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 H 216 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 H 216 SER ASP VAL GLY SER TYR ASN LEU VAL SER TRP TYR GLN SEQRES 4 H 216 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR GLU SEQRES 5 H 216 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 H 216 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 H 216 GLY LEU GLN ALA GLU ASP GLU VAL ASP TYR TYR CYS CYS SEQRES 8 H 216 SER TYR ALA GLY SER SER THR TRP VAL PHE GLY GLY GLY SEQRES 9 H 216 THR LYS LEU THR VAL LEU SER GLN PRO LYS ALA ALA PRO SEQRES 10 H 216 SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11 H 216 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12 H 216 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SEQRES 13 H 216 SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER SEQRES 14 H 216 LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SEQRES 15 H 216 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16 H 216 SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS SEQRES 17 H 216 THR VAL ALA PRO THR GLU CYS SER SEQRES 1 D 231 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 D 231 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 D 231 PHE THR VAL SER SER ASN TYR MET SER TRP VAL ARG GLN SEQRES 4 D 231 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER ALA ILE TYR SEQRES 5 D 231 SER GLY ASP SER THR TYR TYR ALA ASP SER VAL LYS GLY SEQRES 6 D 231 ARG PHE THR ILE SER ARG HIS ASN PRO LYS ASN THR LEU SEQRES 7 D 231 TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA SEQRES 8 D 231 VAL TYR TYR CYS ALA ARG LEU VAL GLY ALA LEU THR ASN SEQRES 9 D 231 ILE VAL VAL SER GLY ASP GLY GLY ALA PHE ASP ILE TRP SEQRES 10 D 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 D 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 D 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 D 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 D 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 D 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 D 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 D 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 D 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 G 216 SER TYR GLU LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 G 216 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 G 216 SER ASP VAL GLY SER TYR ASN LEU VAL SER TRP TYR GLN SEQRES 4 G 216 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR GLU SEQRES 5 G 216 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 G 216 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 G 216 GLY LEU GLN ALA GLU ASP GLU VAL ASP TYR TYR CYS CYS SEQRES 8 G 216 SER TYR ALA GLY SER SER THR TRP VAL PHE GLY GLY GLY SEQRES 9 G 216 THR LYS LEU THR VAL LEU SER GLN PRO LYS ALA ALA PRO SEQRES 10 G 216 SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11 G 216 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12 G 216 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SEQRES 13 G 216 SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER SEQRES 14 G 216 LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SEQRES 15 G 216 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16 G 216 SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS SEQRES 17 G 216 THR VAL ALA PRO THR GLU CYS SER HELIX 1 AA1 ASP A 294 LEU A 303 1 10 HELIX 2 AA2 TYR A 365 ASN A 370 5 6 HELIX 3 AA3 LYS A 386 LEU A 390 5 5 HELIX 4 AA4 ASP A 405 VAL A 407 5 3 HELIX 5 AA5 GLY A 416 ASN A 422 1 7 HELIX 6 AA6 SER A 438 SER A 443 1 6 HELIX 7 AA7 GLY A 502 TYR A 505 5 4 HELIX 8 AA8 ASP A 737 CYS A 743 1 7 HELIX 9 AA9 THR A 747 GLN A 755 1 9 HELIX 10 AB1 TYR A 756 PHE A 782 1 27 HELIX 11 AB2 SER A 816 VAL A 826 1 11 HELIX 12 AB3 ALA A 852 ASN A 856 5 5 HELIX 13 AB4 THR A 866 SER A 884 1 19 HELIX 14 AB5 TRP A 886 GLY A 891 1 6 HELIX 15 AB6 PRO A 897 GLY A 908 1 12 HELIX 16 AB7 THR A 912 GLU A 918 1 7 HELIX 17 AB8 ASN A 919 SER A 939 1 21 HELIX 18 AB9 LEU A 948 SER A 968 1 21 HELIX 19 AC1 VAL A 976 LEU A 984 1 9 HELIX 20 AC2 ASP A 985 CYS A 1032 1 48 HELIX 21 AC3 PRO A 1140 LEU A 1145 1 6 HELIX 22 AC4 ASP B 294 LEU B 303 1 10 HELIX 23 AC5 TYR B 365 ASN B 370 5 6 HELIX 24 AC6 LYS B 386 LEU B 390 5 5 HELIX 25 AC7 ASP B 405 ILE B 410 5 6 HELIX 26 AC8 GLY B 416 ASN B 422 1 7 HELIX 27 AC9 SER B 438 SER B 443 1 6 HELIX 28 AD1 GLY B 502 TYR B 505 5 4 HELIX 29 AD2 ASP B 737 CYS B 743 1 7 HELIX 30 AD3 THR B 747 GLN B 755 1 9 HELIX 31 AD4 TYR B 756 PHE B 782 1 27 HELIX 32 AD5 SER B 816 VAL B 826 1 11 HELIX 33 AD6 ALA B 852 ASN B 856 5 5 HELIX 34 AD7 THR B 866 SER B 884 1 19 HELIX 35 AD8 TRP B 886 GLY B 891 1 6 HELIX 36 AD9 PRO B 897 GLY B 908 1 12 HELIX 37 AE1 THR B 912 GLU B 918 1 7 HELIX 38 AE2 ASN B 919 SER B 939 1 21 HELIX 39 AE3 LEU B 948 SER B 968 1 21 HELIX 40 AE4 VAL B 976 LEU B 984 1 9 HELIX 41 AE5 ASP B 985 CYS B 1032 1 48 HELIX 42 AE6 PRO B 1140 LEU B 1145 1 6 HELIX 43 AE7 ASP C 294 LEU C 303 1 10 HELIX 44 AE8 TYR C 365 ASN C 370 5 6 HELIX 45 AE9 LYS C 386 LEU C 390 5 5 HELIX 46 AF1 ASP C 405 VAL C 407 5 3 HELIX 47 AF2 GLY C 416 ASN C 422 1 7 HELIX 48 AF3 SER C 438 SER C 443 1 6 HELIX 49 AF4 GLY C 502 TYR C 505 5 4 HELIX 50 AF5 ASP C 737 CYS C 743 1 7 HELIX 51 AF6 THR C 747 GLN C 755 1 9 HELIX 52 AF7 TYR C 756 PHE C 782 1 27 HELIX 53 AF8 SER C 816 VAL C 826 1 11 HELIX 54 AF9 ALA C 852 ASN C 856 5 5 HELIX 55 AG1 THR C 866 SER C 884 1 19 HELIX 56 AG2 TRP C 886 GLY C 891 1 6 HELIX 57 AG3 PRO C 897 GLY C 908 1 12 HELIX 58 AG4 THR C 912 GLU C 918 1 7 HELIX 59 AG5 ASN C 919 SER C 939 1 21 HELIX 60 AG6 LEU C 948 SER C 968 1 21 HELIX 61 AG7 VAL C 976 LEU C 984 1 9 HELIX 62 AG8 ASP C 985 CYS C 1032 1 48 HELIX 63 AG9 PRO C 1140 LEU C 1145 1 6 HELIX 64 AH1 THR F 28 ASN F 32 5 5 HELIX 65 AH2 SER F 141 GLY F 147 1 7 HELIX 66 AH3 SER F 170 ALA F 172 5 3 HELIX 67 AH4 SER F 201 LEU F 203 5 3 HELIX 68 AH5 THR I 25 VAL I 29 5 5 HELIX 69 AH6 SER I 125 ALA I 131 1 7 HELIX 70 AH7 THR I 185 LYS I 190 1 6 HELIX 71 AH8 THR E 28 ASN E 32 5 5 HELIX 72 AH9 SER E 141 GLY E 147 1 7 HELIX 73 AI1 SER E 170 ALA E 172 5 3 HELIX 74 AI2 SER E 201 LEU E 203 5 3 HELIX 75 AI3 THR H 25 VAL H 29 5 5 HELIX 76 AI4 SER H 125 ALA H 131 1 7 HELIX 77 AI5 THR H 185 LYS H 190 1 6 HELIX 78 AI6 THR D 28 ASN D 32 5 5 HELIX 79 AI7 SER D 141 GLY D 147 1 7 HELIX 80 AI8 SER D 170 ALA D 172 5 3 HELIX 81 AI9 SER D 201 LEU D 203 5 3 HELIX 82 AJ1 THR G 25 VAL G 29 5 5 HELIX 83 AJ2 SER G 125 ALA G 131 1 7 HELIX 84 AJ3 THR G 185 LYS G 190 1 6 SHEET 1 AA1 6 ALA A 27 ASN A 30 0 SHEET 2 AA1 6 ASN A 61 HIS A 66 -1 O VAL A 62 N THR A 29 SHEET 3 AA1 6 ALA A 264 TYR A 269 -1 O TYR A 265 N PHE A 65 SHEET 4 AA1 6 VAL A 90 GLU A 96 -1 N THR A 95 O ALA A 264 SHEET 5 AA1 6 ASN A 188 PHE A 194 -1 O PHE A 192 N PHE A 92 SHEET 6 AA1 6 LYS A 206 THR A 208 -1 O LYS A 206 N GLU A 191 SHEET 1 AA2 3 HIS A 49 PHE A 55 0 SHEET 2 AA2 3 GLN A 271 TYR A 279 -1 O GLN A 271 N PHE A 55 SHEET 3 AA2 3 ILE A 285 ASP A 290 -1 O VAL A 289 N LEU A 276 SHEET 1 AA3 5 TRP A 152 VAL A 171 0 SHEET 2 AA3 5 VAL A 126 TYR A 145 -1 N GLU A 132 O ASN A 165 SHEET 3 AA3 5 SER A 116 ASN A 121 -1 N LEU A 118 O LYS A 129 SHEET 4 AA3 5 GLY A 103 GLY A 107 -1 N TRP A 104 O ILE A 119 SHEET 5 AA3 5 ARG A 237 THR A 240 -1 O GLN A 239 N ILE A 105 SHEET 1 AA4 3 TRP A 152 VAL A 171 0 SHEET 2 AA4 3 VAL A 126 TYR A 145 -1 N GLU A 132 O ASN A 165 SHEET 3 AA4 3 ALA A 243 ARG A 246 1 O ARG A 246 N TYR A 145 SHEET 1 AA5 2 PHE A 201 ILE A 203 0 SHEET 2 AA5 2 VAL A 227 LEU A 229 -1 O LEU A 229 N PHE A 201 SHEET 1 AA6 5 GLY A 311 GLN A 314 0 SHEET 2 AA6 5 VAL A 595 THR A 599 -1 O THR A 599 N GLY A 311 SHEET 3 AA6 5 ALA A 609 TYR A 612 -1 O LEU A 611 N SER A 596 SHEET 4 AA6 5 CYS A 649 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 5 AA6 5 PHE A 643 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AA7 5 ASN A 354 ILE A 358 0 SHEET 2 AA7 5 THR A 393 ARG A 403 -1 O VAL A 395 N ILE A 358 SHEET 3 AA7 5 PRO A 507 GLU A 516 -1 O TYR A 508 N ILE A 402 SHEET 4 AA7 5 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 5 AA7 5 THR A 376 TYR A 380 -1 N THR A 376 O ALA A 435 SHEET 1 AA8 2 LEU A 452 ARG A 454 0 SHEET 2 AA8 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AA9 5 CYS A 538 PHE A 543 0 SHEET 2 AA9 5 LEU A 546 GLU A 554 -1 O GLY A 550 N VAL A 539 SHEET 3 AA9 5 ILE A 584 THR A 588 -1 O ASP A 586 N THR A 553 SHEET 4 AA9 5 THR A 573 ARG A 577 -1 N VAL A 576 O LEU A 585 SHEET 5 AA9 5 PHE A 565 ARG A 567 -1 N GLY A 566 O ASP A 574 SHEET 1 AB1 4 GLU A 654 HIS A 655 0 SHEET 2 AB1 4 SER A 691 THR A 696 1 O ILE A 692 N GLU A 654 SHEET 3 AB1 4 ILE A 670 GLN A 675 -1 N CYS A 671 O TYR A 695 SHEET 4 AB1 4 ILE A 664 GLY A 667 -1 N GLY A 667 O ILE A 670 SHEET 1 AB2 2 GLU A 702 ASN A 703 0 SHEET 2 AB2 2 ILE B 788 TYR B 789 1 O ILE B 788 N ASN A 703 SHEET 1 AB3 3 SER A 711 PRO A 728 0 SHEET 2 AB3 3 GLY A1059 ALA A1078 -1 O PHE A1075 N ILE A 712 SHEET 3 AB3 3 GLN A1054 ALA A1056 -1 N GLN A1054 O VAL A1061 SHEET 1 AB4 4 TYR A1047 SER A1051 0 SHEET 2 AB4 4 GLY A1059 ALA A1078 -1 O VAL A1065 N LEU A1049 SHEET 3 AB4 4 VAL A1094 SER A1097 -1 O SER A1097 N THR A1076 SHEET 4 AB4 4 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 1 AB5 2 THR A 734 VAL A 736 0 SHEET 2 AB5 2 LEU A 858 VAL A 860 -1 O THR A 859 N SER A 735 SHEET 1 AB6 3 ILE A1081 CYS A1082 0 SHEET 2 AB6 3 ALA A1087 PRO A1090 -1 O HIS A1088 N ILE A1081 SHEET 3 AB6 3 THR A1120 PHE A1121 -1 O PHE A1121 N PHE A1089 SHEET 1 AB7 6 ALA B 27 ASN B 30 0 SHEET 2 AB7 6 ASN B 61 HIS B 66 -1 O VAL B 62 N THR B 29 SHEET 3 AB7 6 ALA B 264 TYR B 269 -1 O TYR B 265 N PHE B 65 SHEET 4 AB7 6 VAL B 90 GLU B 96 -1 N THR B 95 O ALA B 264 SHEET 5 AB7 6 ASN B 188 PHE B 194 -1 O PHE B 192 N PHE B 92 SHEET 6 AB7 6 LYS B 206 THR B 208 -1 O LYS B 206 N GLU B 191 SHEET 1 AB8 3 HIS B 49 PHE B 55 0 SHEET 2 AB8 3 GLN B 271 TYR B 279 -1 O GLN B 271 N PHE B 55 SHEET 3 AB8 3 ILE B 285 ASP B 290 -1 O VAL B 289 N LEU B 276 SHEET 1 AB9 5 TRP B 152 VAL B 171 0 SHEET 2 AB9 5 VAL B 126 TYR B 145 -1 N GLU B 132 O ASN B 165 SHEET 3 AB9 5 SER B 116 ASN B 121 -1 N LEU B 118 O LYS B 129 SHEET 4 AB9 5 GLY B 103 GLY B 107 -1 N TRP B 104 O ILE B 119 SHEET 5 AB9 5 ARG B 237 THR B 240 -1 O GLN B 239 N ILE B 105 SHEET 1 AC1 3 TRP B 152 VAL B 171 0 SHEET 2 AC1 3 VAL B 126 TYR B 145 -1 N GLU B 132 O ASN B 165 SHEET 3 AC1 3 ALA B 243 ARG B 246 1 O ARG B 246 N TYR B 145 SHEET 1 AC2 2 PHE B 201 ILE B 203 0 SHEET 2 AC2 2 VAL B 227 LEU B 229 -1 O LEU B 229 N PHE B 201 SHEET 1 AC3 5 GLY B 311 GLN B 314 0 SHEET 2 AC3 5 VAL B 595 THR B 599 -1 O THR B 599 N GLY B 311 SHEET 3 AC3 5 ALA B 609 TYR B 612 -1 O LEU B 611 N SER B 596 SHEET 4 AC3 5 CYS B 649 ILE B 651 -1 O CYS B 649 N TYR B 612 SHEET 5 AC3 5 PHE B 643 GLN B 644 -1 N PHE B 643 O LEU B 650 SHEET 1 AC4 5 ASN B 354 ILE B 358 0 SHEET 2 AC4 5 THR B 393 ARG B 403 -1 O VAL B 395 N ILE B 358 SHEET 3 AC4 5 PRO B 507 GLU B 516 -1 O TYR B 508 N ILE B 402 SHEET 4 AC4 5 GLY B 431 ASN B 437 -1 N ILE B 434 O VAL B 511 SHEET 5 AC4 5 THR B 376 TYR B 380 -1 N THR B 376 O ALA B 435 SHEET 1 AC5 2 LEU B 452 ARG B 454 0 SHEET 2 AC5 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AC6 5 CYS B 538 PHE B 543 0 SHEET 2 AC6 5 LEU B 546 GLU B 554 -1 O GLY B 550 N VAL B 539 SHEET 3 AC6 5 ILE B 584 THR B 588 -1 O ASP B 586 N THR B 553 SHEET 4 AC6 5 THR B 573 ARG B 577 -1 N VAL B 576 O LEU B 585 SHEET 5 AC6 5 PHE B 565 ARG B 567 -1 N GLY B 566 O ASP B 574 SHEET 1 AC7 4 GLU B 654 HIS B 655 0 SHEET 2 AC7 4 SER B 691 THR B 696 1 O ILE B 692 N GLU B 654 SHEET 3 AC7 4 ILE B 670 GLN B 675 -1 N CYS B 671 O TYR B 695 SHEET 4 AC7 4 ILE B 664 GLY B 667 -1 N GLY B 667 O ILE B 670 SHEET 1 AC8 2 GLU B 702 ASN B 703 0 SHEET 2 AC8 2 ILE C 788 TYR C 789 1 O ILE C 788 N ASN B 703 SHEET 1 AC9 3 SER B 711 PRO B 728 0 SHEET 2 AC9 3 GLY B1059 ALA B1078 -1 O PHE B1075 N ILE B 712 SHEET 3 AC9 3 GLN B1054 ALA B1056 -1 N GLN B1054 O VAL B1061 SHEET 1 AD1 4 TYR B1047 SER B1051 0 SHEET 2 AD1 4 GLY B1059 ALA B1078 -1 O VAL B1065 N LEU B1049 SHEET 3 AD1 4 VAL B1094 SER B1097 -1 O SER B1097 N THR B1076 SHEET 4 AD1 4 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 1 AD2 2 THR B 734 VAL B 736 0 SHEET 2 AD2 2 LEU B 858 VAL B 860 -1 O THR B 859 N SER B 735 SHEET 1 AD3 3 ILE B1081 CYS B1082 0 SHEET 2 AD3 3 ALA B1087 PRO B1090 -1 O HIS B1088 N ILE B1081 SHEET 3 AD3 3 THR B1120 PHE B1121 -1 O PHE B1121 N PHE B1089 SHEET 1 AD4 6 ALA C 27 ASN C 30 0 SHEET 2 AD4 6 ASN C 61 HIS C 66 -1 O VAL C 62 N THR C 29 SHEET 3 AD4 6 ALA C 264 TYR C 269 -1 O TYR C 265 N PHE C 65 SHEET 4 AD4 6 VAL C 90 GLU C 96 -1 N THR C 95 O ALA C 264 SHEET 5 AD4 6 ASN C 188 PHE C 194 -1 O PHE C 192 N PHE C 92 SHEET 6 AD4 6 LYS C 206 THR C 208 -1 O LYS C 206 N GLU C 191 SHEET 1 AD5 3 HIS C 49 PHE C 55 0 SHEET 2 AD5 3 GLN C 271 TYR C 279 -1 O GLN C 271 N PHE C 55 SHEET 3 AD5 3 ILE C 285 ASP C 290 -1 O VAL C 289 N LEU C 276 SHEET 1 AD6 5 TRP C 152 VAL C 171 0 SHEET 2 AD6 5 VAL C 126 TYR C 145 -1 N GLU C 132 O ASN C 165 SHEET 3 AD6 5 SER C 116 ASN C 121 -1 N LEU C 118 O LYS C 129 SHEET 4 AD6 5 GLY C 103 GLY C 107 -1 N TRP C 104 O ILE C 119 SHEET 5 AD6 5 ARG C 237 THR C 240 -1 O GLN C 239 N ILE C 105 SHEET 1 AD7 3 TRP C 152 VAL C 171 0 SHEET 2 AD7 3 VAL C 126 TYR C 145 -1 N GLU C 132 O ASN C 165 SHEET 3 AD7 3 ALA C 243 ARG C 246 1 O ARG C 246 N TYR C 145 SHEET 1 AD8 2 PHE C 201 ILE C 203 0 SHEET 2 AD8 2 VAL C 227 LEU C 229 -1 O LEU C 229 N PHE C 201 SHEET 1 AD9 5 GLY C 311 GLN C 314 0 SHEET 2 AD9 5 VAL C 595 THR C 599 -1 O THR C 599 N GLY C 311 SHEET 3 AD9 5 ALA C 609 TYR C 612 -1 O LEU C 611 N SER C 596 SHEET 4 AD9 5 CYS C 649 ILE C 651 -1 O CYS C 649 N TYR C 612 SHEET 5 AD9 5 PHE C 643 GLN C 644 -1 N PHE C 643 O LEU C 650 SHEET 1 AE1 5 ASN C 354 ILE C 358 0 SHEET 2 AE1 5 THR C 393 ARG C 403 -1 O VAL C 395 N ILE C 358 SHEET 3 AE1 5 PRO C 507 GLU C 516 -1 O TYR C 508 N ILE C 402 SHEET 4 AE1 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AE1 5 THR C 376 TYR C 380 -1 N THR C 376 O ALA C 435 SHEET 1 AE2 2 LEU C 452 ARG C 454 0 SHEET 2 AE2 2 LEU C 492 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AE3 5 CYS C 538 PHE C 543 0 SHEET 2 AE3 5 LEU C 546 GLU C 554 -1 O GLY C 550 N VAL C 539 SHEET 3 AE3 5 ILE C 584 THR C 588 -1 O ASP C 586 N THR C 553 SHEET 4 AE3 5 THR C 573 ARG C 577 -1 N VAL C 576 O LEU C 585 SHEET 5 AE3 5 PHE C 565 ARG C 567 -1 N GLY C 566 O ASP C 574 SHEET 1 AE4 4 GLU C 654 HIS C 655 0 SHEET 2 AE4 4 SER C 691 THR C 696 1 O ILE C 692 N GLU C 654 SHEET 3 AE4 4 ILE C 670 GLN C 675 -1 N CYS C 671 O TYR C 695 SHEET 4 AE4 4 ILE C 664 GLY C 667 -1 N GLY C 667 O ILE C 670 SHEET 1 AE5 3 SER C 711 PRO C 728 0 SHEET 2 AE5 3 GLY C1059 ALA C1078 -1 O PHE C1075 N ILE C 712 SHEET 3 AE5 3 GLN C1054 ALA C1056 -1 N GLN C1054 O VAL C1061 SHEET 1 AE6 4 TYR C1047 SER C1051 0 SHEET 2 AE6 4 GLY C1059 ALA C1078 -1 O VAL C1065 N LEU C1049 SHEET 3 AE6 4 VAL C1094 SER C1097 -1 O SER C1097 N THR C1076 SHEET 4 AE6 4 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 1 AE7 2 THR C 734 VAL C 736 0 SHEET 2 AE7 2 LEU C 858 VAL C 860 -1 O THR C 859 N SER C 735 SHEET 1 AE8 3 ILE C1081 CYS C1082 0 SHEET 2 AE8 3 ALA C1087 PRO C1090 -1 O HIS C1088 N ILE C1081 SHEET 3 AE8 3 THR C1120 PHE C1121 -1 O PHE C1121 N PHE C1089 SHEET 1 AE9 3 GLN F 3 SER F 7 0 SHEET 2 AE9 3 LEU F 18 SER F 25 -1 O ALA F 23 N VAL F 5 SHEET 3 AE9 3 THR F 77 MET F 82 -1 O LEU F 78 N CYS F 22 SHEET 1 AF1 3 GLU F 46 TRP F 47 0 SHEET 2 AF1 3 SER F 35 GLN F 39 -1 N ARG F 38 O GLU F 46 SHEET 3 AF1 3 VAL F 92 ALA F 96 -1 O TYR F 94 N VAL F 37 SHEET 1 AF2 4 SER F 134 LEU F 138 0 SHEET 2 AF2 4 THR F 149 TYR F 159 -1 O LEU F 155 N PHE F 136 SHEET 3 AF2 4 TYR F 190 PRO F 199 -1 O VAL F 198 N ALA F 150 SHEET 4 AF2 4 VAL F 177 LEU F 184 -1 N HIS F 178 O VAL F 195 SHEET 1 AF3 3 THR F 165 TRP F 168 0 SHEET 2 AF3 3 TYR F 208 HIS F 214 -1 O ASN F 211 N SER F 167 SHEET 3 AF3 3 THR F 219 VAL F 225 -1 O VAL F 225 N TYR F 208 SHEET 1 AF4 3 SER I 9 GLY I 12 0 SHEET 2 AF4 3 THR I 105 VAL I 109 1 O LYS I 106 N VAL I 10 SHEET 3 AF4 3 ASP I 87 TYR I 88 -1 N TYR I 88 O THR I 105 SHEET 1 AF5 3 SER I 17 ILE I 20 0 SHEET 2 AF5 3 THR I 72 SER I 78 -1 O ILE I 77 N ILE I 18 SHEET 3 AF5 3 PHE I 64 SER I 69 -1 N SER I 69 O THR I 72 SHEET 1 AF6 2 SER I 92 TYR I 93 0 SHEET 2 AF6 2 TRP I 99 VAL I 100 -1 O VAL I 100 N SER I 92 SHEET 1 AF7 4 SER I 118 PHE I 122 0 SHEET 2 AF7 4 ALA I 134 PHE I 143 -1 O SER I 141 N SER I 118 SHEET 3 AF7 4 TYR I 176 LEU I 184 -1 O SER I 180 N CYS I 138 SHEET 4 AF7 4 VAL I 163 THR I 165 -1 N GLU I 164 O TYR I 181 SHEET 1 AF8 4 SER I 118 PHE I 122 0 SHEET 2 AF8 4 ALA I 134 PHE I 143 -1 O SER I 141 N SER I 118 SHEET 3 AF8 4 TYR I 176 LEU I 184 -1 O SER I 180 N CYS I 138 SHEET 4 AF8 4 SER I 169 LYS I 170 -1 N SER I 169 O ALA I 177 SHEET 1 AF9 3 VAL I 150 ALA I 154 0 SHEET 2 AF9 3 TYR I 195 HIS I 201 -1 O GLN I 198 N ALA I 151 SHEET 3 AF9 3 SER I 204 THR I 205 -1 O SER I 204 N HIS I 201 SHEET 1 AG1 3 VAL I 150 ALA I 154 0 SHEET 2 AG1 3 TYR I 195 HIS I 201 -1 O GLN I 198 N ALA I 151 SHEET 3 AG1 3 LYS I 208 VAL I 210 -1 O VAL I 210 N TYR I 195 SHEET 1 AG2 3 GLN E 3 SER E 7 0 SHEET 2 AG2 3 LEU E 18 SER E 25 -1 O ALA E 23 N VAL E 5 SHEET 3 AG2 3 THR E 77 MET E 82 -1 O LEU E 78 N CYS E 22 SHEET 1 AG3 3 GLU E 46 TRP E 47 0 SHEET 2 AG3 3 SER E 35 GLN E 39 -1 N ARG E 38 O GLU E 46 SHEET 3 AG3 3 VAL E 92 ALA E 96 -1 O TYR E 94 N VAL E 37 SHEET 1 AG4 4 SER E 134 LEU E 138 0 SHEET 2 AG4 4 THR E 149 TYR E 159 -1 O LEU E 155 N PHE E 136 SHEET 3 AG4 4 TYR E 190 PRO E 199 -1 O VAL E 198 N ALA E 150 SHEET 4 AG4 4 VAL E 177 LEU E 184 -1 N HIS E 178 O VAL E 195 SHEET 1 AG5 3 THR E 165 TRP E 168 0 SHEET 2 AG5 3 TYR E 208 HIS E 214 -1 O ASN E 211 N SER E 167 SHEET 3 AG5 3 THR E 219 VAL E 225 -1 O VAL E 225 N TYR E 208 SHEET 1 AG6 3 SER H 9 GLY H 12 0 SHEET 2 AG6 3 THR H 105 VAL H 109 1 O LYS H 106 N VAL H 10 SHEET 3 AG6 3 ASP H 87 TYR H 88 -1 N TYR H 88 O THR H 105 SHEET 1 AG7 3 SER H 17 ILE H 20 0 SHEET 2 AG7 3 THR H 72 SER H 78 -1 O ILE H 77 N ILE H 18 SHEET 3 AG7 3 PHE H 64 SER H 69 -1 N SER H 69 O THR H 72 SHEET 1 AG8 2 SER H 92 TYR H 93 0 SHEET 2 AG8 2 TRP H 99 VAL H 100 -1 O VAL H 100 N SER H 92 SHEET 1 AG9 4 SER H 118 PHE H 122 0 SHEET 2 AG9 4 ALA H 134 PHE H 143 -1 O SER H 141 N SER H 118 SHEET 3 AG9 4 TYR H 176 LEU H 184 -1 O SER H 180 N CYS H 138 SHEET 4 AG9 4 VAL H 163 THR H 165 -1 N GLU H 164 O TYR H 181 SHEET 1 AH1 4 SER H 118 PHE H 122 0 SHEET 2 AH1 4 ALA H 134 PHE H 143 -1 O SER H 141 N SER H 118 SHEET 3 AH1 4 TYR H 176 LEU H 184 -1 O SER H 180 N CYS H 138 SHEET 4 AH1 4 SER H 169 LYS H 170 -1 N SER H 169 O ALA H 177 SHEET 1 AH2 3 VAL H 150 ALA H 154 0 SHEET 2 AH2 3 TYR H 195 HIS H 201 -1 O GLN H 198 N ALA H 151 SHEET 3 AH2 3 SER H 204 THR H 205 -1 O SER H 204 N HIS H 201 SHEET 1 AH3 3 VAL H 150 ALA H 154 0 SHEET 2 AH3 3 TYR H 195 HIS H 201 -1 O GLN H 198 N ALA H 151 SHEET 3 AH3 3 LYS H 208 VAL H 210 -1 O VAL H 210 N TYR H 195 SHEET 1 AH4 3 GLN D 3 SER D 7 0 SHEET 2 AH4 3 LEU D 18 SER D 25 -1 O ALA D 23 N VAL D 5 SHEET 3 AH4 3 THR D 77 MET D 82 -1 O LEU D 78 N CYS D 22 SHEET 1 AH5 3 GLU D 46 TRP D 47 0 SHEET 2 AH5 3 SER D 35 GLN D 39 -1 N ARG D 38 O GLU D 46 SHEET 3 AH5 3 VAL D 92 ALA D 96 -1 O TYR D 94 N VAL D 37 SHEET 1 AH6 4 SER D 134 LEU D 138 0 SHEET 2 AH6 4 THR D 149 TYR D 159 -1 O LEU D 155 N PHE D 136 SHEET 3 AH6 4 TYR D 190 PRO D 199 -1 O VAL D 198 N ALA D 150 SHEET 4 AH6 4 VAL D 177 LEU D 184 -1 N HIS D 178 O VAL D 195 SHEET 1 AH7 3 THR D 165 TRP D 168 0 SHEET 2 AH7 3 TYR D 208 HIS D 214 -1 O ASN D 211 N SER D 167 SHEET 3 AH7 3 THR D 219 VAL D 225 -1 O VAL D 225 N TYR D 208 SHEET 1 AH8 3 SER G 9 GLY G 12 0 SHEET 2 AH8 3 THR G 105 VAL G 109 1 O LYS G 106 N VAL G 10 SHEET 3 AH8 3 ASP G 87 TYR G 88 -1 N TYR G 88 O THR G 105 SHEET 1 AH9 3 SER G 17 ILE G 20 0 SHEET 2 AH9 3 THR G 72 SER G 78 -1 O ILE G 77 N ILE G 18 SHEET 3 AH9 3 PHE G 64 SER G 69 -1 N SER G 69 O THR G 72 SHEET 1 AI1 2 SER G 92 TYR G 93 0 SHEET 2 AI1 2 TRP G 99 VAL G 100 -1 O VAL G 100 N SER G 92 SHEET 1 AI2 4 SER G 118 PHE G 122 0 SHEET 2 AI2 4 ALA G 134 PHE G 143 -1 O SER G 141 N SER G 118 SHEET 3 AI2 4 TYR G 176 LEU G 184 -1 O SER G 180 N CYS G 138 SHEET 4 AI2 4 VAL G 163 THR G 165 -1 N GLU G 164 O TYR G 181 SHEET 1 AI3 4 SER G 118 PHE G 122 0 SHEET 2 AI3 4 ALA G 134 PHE G 143 -1 O SER G 141 N SER G 118 SHEET 3 AI3 4 TYR G 176 LEU G 184 -1 O SER G 180 N CYS G 138 SHEET 4 AI3 4 SER G 169 LYS G 170 -1 N SER G 169 O ALA G 177 SHEET 1 AI4 3 VAL G 150 ALA G 154 0 SHEET 2 AI4 3 TYR G 195 HIS G 201 -1 O GLN G 198 N ALA G 151 SHEET 3 AI4 3 SER G 204 THR G 205 -1 O SER G 204 N HIS G 201 SHEET 1 AI5 3 VAL G 150 ALA G 154 0 SHEET 2 AI5 3 TYR G 195 HIS G 201 -1 O GLN G 198 N ALA G 151 SHEET 3 AI5 3 LYS G 208 VAL G 210 -1 O VAL G 210 N TYR G 195 SSBOND 1 CYS A 15 CYS A 136 1555 1555 2.03 SSBOND 2 CYS A 131 CYS A 166 1555 1555 2.03 SSBOND 3 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 4 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 5 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 6 CYS A 391 CYS A 525 1555 1555 2.04 SSBOND 7 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 8 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 9 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 10 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 11 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 12 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 13 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 14 CYS A 1082 CYS A 1126 1555 1555 2.03 SSBOND 15 CYS B 15 CYS B 136 1555 1555 2.03 SSBOND 16 CYS B 131 CYS B 166 1555 1555 2.03 SSBOND 17 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 18 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 19 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 20 CYS B 391 CYS B 525 1555 1555 2.04 SSBOND 21 CYS B 480 CYS B 488 1555 1555 2.03 SSBOND 22 CYS B 538 CYS B 590 1555 1555 2.03 SSBOND 23 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 24 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 25 CYS B 738 CYS B 760 1555 1555 2.03 SSBOND 26 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 27 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 28 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 29 CYS C 15 CYS C 136 1555 1555 2.03 SSBOND 30 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 31 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 32 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 33 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 34 CYS C 391 CYS C 525 1555 1555 2.04 SSBOND 35 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 36 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 37 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 38 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 39 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 40 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 41 CYS C 1032 CYS C 1043 1555 1555 2.03 SSBOND 42 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 43 CYS F 22 CYS F 95 1555 1555 2.03 SSBOND 44 CYS F 154 CYS F 210 1555 1555 2.03 SSBOND 45 CYS F 230 CYS I 215 1555 1555 2.03 SSBOND 46 CYS I 22 CYS I 90 1555 1555 2.03 SSBOND 47 CYS I 138 CYS I 197 1555 1555 2.03 SSBOND 48 CYS E 22 CYS E 95 1555 1555 2.03 SSBOND 49 CYS E 154 CYS E 210 1555 1555 2.03 SSBOND 50 CYS E 230 CYS H 215 1555 1555 2.03 SSBOND 51 CYS H 22 CYS H 90 1555 1555 2.03 SSBOND 52 CYS H 138 CYS H 197 1555 1555 2.03 SSBOND 53 CYS D 22 CYS D 95 1555 1555 2.03 SSBOND 54 CYS D 154 CYS D 210 1555 1555 2.03 SSBOND 55 CYS D 230 CYS G 215 1555 1555 2.03 SSBOND 56 CYS G 22 CYS G 90 1555 1555 2.03 SSBOND 57 CYS G 138 CYS G 197 1555 1555 2.03 CISPEP 1 PHE F 160 PRO F 161 0 -3.65 CISPEP 2 GLU F 162 PRO F 163 0 -2.11 CISPEP 3 TYR I 144 PRO I 145 0 -1.51 CISPEP 4 PHE E 160 PRO E 161 0 -3.64 CISPEP 5 GLU E 162 PRO E 163 0 -2.04 CISPEP 6 TYR H 144 PRO H 145 0 -1.49 CISPEP 7 PHE D 160 PRO D 161 0 -3.64 CISPEP 8 GLU D 162 PRO D 163 0 -2.12 CISPEP 9 TYR G 144 PRO G 145 0 -1.45 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000