HEADER VIRAL PROTEIN 05-MAR-24 8YKG TITLE STRUCTURE OF SARS-COV-2 SPIKE GLYCOPROTEIN IN COMPLEX WITH NT-108 SCFV TITLE 2 (1-UP STATE) COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MUTATION: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: NT-108 SCFV; COMPND 9 CHAIN: D, F; COMPND 10 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_TAXID: 2697049; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_TAXID: 9606; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS ANTIBODY, COMPLEX, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR Y.ANRAKU,S.KITA,T.ONODERA,T.TADOKORO,S.ITO,Y.ADACHI,R.KOTAKI, AUTHOR 2 T.SUZUKI,T.HASHIGUCHI,Y.TAKAHASHI,K.MAENAKA REVDAT 1 12-MAR-25 8YKG 0 JRNL AUTH Y.ANRAKU,K.MAENAKA JRNL TITL STRUCTURAL BASIS FOR POTENT NEUTRALIZATION ACTIVITY OF JRNL TITL 2 SARS-COV-2 ANTIBODY, NT-108 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.28 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOLO, EPU, RELION, PHENIX, RELION, REMARK 3 RELION, RELION, RELION REMARK 3 RECONSTRUCTION SCHEMA : FOURIER SPACE REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 7K8X REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.280 REMARK 3 NUMBER OF PARTICLES : 84530 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8YKG COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 05-MAR-24. REMARK 100 THE DEPOSITION ID IS D_1300041953. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV-2 SPIKE GLYCOPROTEIN REMARK 245 IN COMPLEX WITH NT-108 SCFV; REMARK 245 SARS-COV-2 SPIKE GLYCOPROTEIN; REMARK 245 NT-108 SCFV REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.10 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : BLOTTING TIME 5 S AND BLOTTING REMARK 245 FORCE 5. REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 2832 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1800.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5352.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 130000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, F, E, G REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER A 12 REMARK 465 SER A 13 REMARK 465 GLN A 14 REMARK 465 CYS A 15 REMARK 465 VAL A 16 REMARK 465 ASN A 17 REMARK 465 LEU A 18 REMARK 465 THR A 19 REMARK 465 THR A 20 REMARK 465 ARG A 21 REMARK 465 THR A 22 REMARK 465 GLN A 23 REMARK 465 LEU A 24 REMARK 465 PRO A 25 REMARK 465 PRO A 26 REMARK 465 HIS A 66 REMARK 465 ALA A 67 REMARK 465 ILE A 68 REMARK 465 HIS A 69 REMARK 465 VAL A 70 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 76 REMARK 465 LYS A 77 REMARK 465 ARG A 78 REMARK 465 PHE A 79 REMARK 465 CYS A 136 REMARK 465 ASN A 137 REMARK 465 ASP A 138 REMARK 465 PRO A 139 REMARK 465 PHE A 140 REMARK 465 LEU A 141 REMARK 465 GLY A 142 REMARK 465 VAL A 143 REMARK 465 TYR A 144 REMARK 465 TYR A 145 REMARK 465 HIS A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 MET A 153 REMARK 465 GLU A 154 REMARK 465 SER A 155 REMARK 465 GLU A 156 REMARK 465 PHE A 157 REMARK 465 ARG A 158 REMARK 465 VAL A 159 REMARK 465 TYR A 160 REMARK 465 SER A 161 REMARK 465 SER A 162 REMARK 465 ALA A 163 REMARK 465 ASN A 164 REMARK 465 GLN A 173 REMARK 465 PRO A 174 REMARK 465 PHE A 175 REMARK 465 LEU A 176 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLN A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 PHE A 186 REMARK 465 LEU A 242 REMARK 465 ALA A 243 REMARK 465 LEU A 244 REMARK 465 HIS A 245 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 ALA A 262 REMARK 465 ALA A 263 REMARK 465 GLN A 474 REMARK 465 ALA A 475 REMARK 465 GLY A 476 REMARK 465 SER A 477 REMARK 465 THR A 478 REMARK 465 PRO A 479 REMARK 465 CYS A 480 REMARK 465 ASN A 481 REMARK 465 GLY A 482 REMARK 465 VAL A 483 REMARK 465 GLU A 484 REMARK 465 GLY A 485 REMARK 465 PHE A 486 REMARK 465 ASN A 487 REMARK 465 CYS A 488 REMARK 465 TYR A 489 REMARK 465 LEU A 518 REMARK 465 HIS A 519 REMARK 465 ALA A 520 REMARK 465 PRO A 621 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 SER A 640 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 ASN A 679 REMARK 465 SER A 680 REMARK 465 PRO A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 GLY A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 LYS A 854 REMARK 465 LEU A 1145 REMARK 465 ASP A 1146 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 TYR A 1209 REMARK 465 ILE A 1210 REMARK 465 SER B 12 REMARK 465 SER B 13 REMARK 465 GLN B 14 REMARK 465 CYS B 15 REMARK 465 VAL B 16 REMARK 465 ASN B 17 REMARK 465 LEU B 18 REMARK 465 THR B 19 REMARK 465 THR B 20 REMARK 465 ARG B 21 REMARK 465 THR B 22 REMARK 465 GLN B 23 REMARK 465 LEU B 24 REMARK 465 PRO B 25 REMARK 465 PRO B 26 REMARK 465 HIS B 69 REMARK 465 VAL B 70 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 THR B 76 REMARK 465 LYS B 77 REMARK 465 ARG B 78 REMARK 465 PHE B 79 REMARK 465 ASP B 80 REMARK 465 ASN B 121 REMARK 465 ASN B 122 REMARK 465 ALA B 123 REMARK 465 THR B 124 REMARK 465 ASN B 125 REMARK 465 VAL B 126 REMARK 465 GLU B 132 REMARK 465 PHE B 133 REMARK 465 GLN B 134 REMARK 465 PHE B 135 REMARK 465 CYS B 136 REMARK 465 ASN B 137 REMARK 465 ASP B 138 REMARK 465 PRO B 139 REMARK 465 PHE B 140 REMARK 465 LEU B 141 REMARK 465 GLY B 142 REMARK 465 VAL B 143 REMARK 465 TYR B 144 REMARK 465 TYR B 145 REMARK 465 HIS B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASN B 149 REMARK 465 LYS B 150 REMARK 465 SER B 151 REMARK 465 TRP B 152 REMARK 465 MET B 153 REMARK 465 GLU B 154 REMARK 465 SER B 155 REMARK 465 GLU B 156 REMARK 465 PHE B 157 REMARK 465 ARG B 158 REMARK 465 VAL B 159 REMARK 465 TYR B 160 REMARK 465 SER B 161 REMARK 465 SER B 162 REMARK 465 ALA B 163 REMARK 465 ASN B 164 REMARK 465 GLN B 173 REMARK 465 PRO B 174 REMARK 465 PHE B 175 REMARK 465 LEU B 176 REMARK 465 MET B 177 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLN B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 PHE B 186 REMARK 465 LEU B 244 REMARK 465 HIS B 245 REMARK 465 ARG B 246 REMARK 465 SER B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 GLY B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 SER B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 TRP B 258 REMARK 465 THR B 259 REMARK 465 ALA B 260 REMARK 465 GLY B 261 REMARK 465 ALA B 262 REMARK 465 LEU B 518 REMARK 465 HIS B 519 REMARK 465 PRO B 621 REMARK 465 VAL B 622 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 TYR B 636 REMARK 465 SER B 637 REMARK 465 THR B 638 REMARK 465 GLY B 639 REMARK 465 SER B 640 REMARK 465 GLN B 677 REMARK 465 THR B 678 REMARK 465 ASN B 679 REMARK 465 SER B 680 REMARK 465 PRO B 681 REMARK 465 GLY B 682 REMARK 465 SER B 683 REMARK 465 ALA B 684 REMARK 465 GLY B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 CYS B 851 REMARK 465 ALA B 852 REMARK 465 GLN B 853 REMARK 465 LYS B 854 REMARK 465 LEU B 1145 REMARK 465 ASP B 1146 REMARK 465 SER B 1147 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 TYR B 1209 REMARK 465 ILE B 1210 REMARK 465 SER C 12 REMARK 465 SER C 13 REMARK 465 GLN C 14 REMARK 465 CYS C 15 REMARK 465 VAL C 16 REMARK 465 ASN C 17 REMARK 465 LEU C 18 REMARK 465 THR C 19 REMARK 465 THR C 20 REMARK 465 ARG C 21 REMARK 465 THR C 22 REMARK 465 GLN C 23 REMARK 465 LEU C 24 REMARK 465 PRO C 25 REMARK 465 PRO C 26 REMARK 465 VAL C 70 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 76 REMARK 465 LYS C 77 REMARK 465 ARG C 78 REMARK 465 PHE C 79 REMARK 465 ASP C 80 REMARK 465 GLU C 96 REMARK 465 LYS C 97 REMARK 465 SER C 98 REMARK 465 ASN C 99 REMARK 465 ILE C 100 REMARK 465 ILE C 101 REMARK 465 ARG C 102 REMARK 465 ASN C 121 REMARK 465 ASN C 122 REMARK 465 ALA C 123 REMARK 465 THR C 124 REMARK 465 ASN C 125 REMARK 465 VAL C 126 REMARK 465 PHE C 133 REMARK 465 GLN C 134 REMARK 465 PHE C 135 REMARK 465 CYS C 136 REMARK 465 ASN C 137 REMARK 465 ASP C 138 REMARK 465 PRO C 139 REMARK 465 PHE C 140 REMARK 465 LEU C 141 REMARK 465 GLY C 142 REMARK 465 VAL C 143 REMARK 465 TYR C 144 REMARK 465 TYR C 145 REMARK 465 HIS C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 MET C 153 REMARK 465 GLU C 154 REMARK 465 SER C 155 REMARK 465 GLU C 156 REMARK 465 PHE C 157 REMARK 465 ARG C 158 REMARK 465 VAL C 159 REMARK 465 TYR C 160 REMARK 465 SER C 161 REMARK 465 SER C 162 REMARK 465 ALA C 163 REMARK 465 ASN C 164 REMARK 465 ASN C 165 REMARK 465 GLN C 173 REMARK 465 PRO C 174 REMARK 465 PHE C 175 REMARK 465 LEU C 176 REMARK 465 MET C 177 REMARK 465 ASP C 178 REMARK 465 LEU C 179 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLN C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 PHE C 186 REMARK 465 ILE C 210 REMARK 465 ASN C 211 REMARK 465 LEU C 212 REMARK 465 VAL C 213 REMARK 465 ARG C 214 REMARK 465 ASP C 215 REMARK 465 LEU C 216 REMARK 465 ALA C 243 REMARK 465 LEU C 244 REMARK 465 HIS C 245 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 GLY C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 GLY C 261 REMARK 465 ALA C 262 REMARK 465 LEU C 518 REMARK 465 HIS C 519 REMARK 465 PRO C 621 REMARK 465 VAL C 622 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 THR C 638 REMARK 465 GLY C 639 REMARK 465 SER C 640 REMARK 465 GLN C 677 REMARK 465 THR C 678 REMARK 465 ASN C 679 REMARK 465 SER C 680 REMARK 465 PRO C 681 REMARK 465 GLY C 682 REMARK 465 SER C 683 REMARK 465 ALA C 684 REMARK 465 GLY C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 CYS C 851 REMARK 465 ALA C 852 REMARK 465 GLN C 853 REMARK 465 LYS C 854 REMARK 465 LEU C 1145 REMARK 465 ASP C 1146 REMARK 465 SER C 1147 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 TYR C 1209 REMARK 465 ILE C 1210 REMARK 465 GLU D 0 REMARK 465 GLY D 107 REMARK 465 GLY D 108 REMARK 465 GLY D 109 REMARK 465 GLY D 110 REMARK 465 SER D 111 REMARK 465 GLY D 112 REMARK 465 GLY D 113 REMARK 465 GLY D 114 REMARK 465 GLY D 115 REMARK 465 SER D 116 REMARK 465 GLY D 117 REMARK 465 GLY D 118 REMARK 465 GLY D 119 REMARK 465 GLY D 120 REMARK 465 HIS D 245 REMARK 465 HIS D 246 REMARK 465 HIS D 247 REMARK 465 HIS D 248 REMARK 465 HIS D 249 REMARK 465 HIS D 250 REMARK 465 GLU F 0 REMARK 465 GLY F 107 REMARK 465 GLY F 108 REMARK 465 GLY F 109 REMARK 465 GLY F 110 REMARK 465 SER F 111 REMARK 465 GLY F 112 REMARK 465 GLY F 113 REMARK 465 GLY F 114 REMARK 465 GLY F 115 REMARK 465 SER F 116 REMARK 465 GLY F 117 REMARK 465 GLY F 118 REMARK 465 GLY F 119 REMARK 465 GLY F 120 REMARK 465 HIS F 245 REMARK 465 HIS F 246 REMARK 465 HIS F 247 REMARK 465 HIS F 248 REMARK 465 HIS F 249 REMARK 465 HIS F 250 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 NE2 GLN C 926 O4 NAG C 1305 1.30 REMARK 500 OG SER A 758 OG1 THR A 761 2.18 REMARK 500 O ASP B 290 OG SER B 297 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 81 71.59 -155.91 REMARK 500 SER A 112 -1.67 66.57 REMARK 500 ASN A 122 56.07 -90.97 REMARK 500 ALA A 123 -7.20 73.25 REMARK 500 LEU A 212 147.88 -174.48 REMARK 500 ILE A 231 -63.77 -104.82 REMARK 500 TYR A 380 -60.40 -91.33 REMARK 500 ASN A 710 31.31 -140.70 REMARK 500 VAL A 729 -52.92 -126.21 REMARK 500 ASN A 856 54.30 -92.56 REMARK 500 THR B 33 -0.73 -140.73 REMARK 500 SER B 112 -1.94 69.21 REMARK 500 LEU B 293 -60.72 -96.43 REMARK 500 PRO B 337 45.97 -79.85 REMARK 500 ASN B 370 51.15 -93.33 REMARK 500 THR B 385 -0.88 69.34 REMARK 500 ALA B 419 4.86 -69.00 REMARK 500 CYS B 525 -173.87 -171.69 REMARK 500 ASN B 710 30.66 -141.85 REMARK 500 GLN B1106 -178.27 -69.43 REMARK 500 THR C 114 79.33 -102.55 REMARK 500 SER C 316 -169.95 -160.80 REMARK 500 THR C 333 -138.18 55.75 REMARK 500 ASN C 370 52.44 -93.11 REMARK 500 ALA C 372 12.40 59.23 REMARK 500 THR C 385 -4.26 66.56 REMARK 500 PHE C 400 -177.74 -170.62 REMARK 500 TYR C 505 58.39 -96.07 REMARK 500 ASN C 536 19.43 59.28 REMARK 500 ALA C 570 49.75 -92.99 REMARK 500 PRO C 942 43.97 -88.05 REMARK 500 SER C 943 19.42 -142.27 REMARK 500 PHE C 970 17.84 57.47 REMARK 500 PHE C1109 116.03 -160.83 REMARK 500 SER D 52 -31.47 -130.31 REMARK 500 ALA F 51 -6.69 74.45 REMARK 500 PRO F 80 0.44 -59.50 REMARK 500 ALA F 84 -166.78 -161.55 REMARK 500 SER F 151 30.94 -94.53 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-39370 RELATED DB: EMDB REMARK 900 STRUCTURE OF SARS-COV-2 SPIKE GLYCOPROTEIN IN COMPLEX WITH NT-108 REMARK 900 SCFV (1-UP STATE) DBREF 8YKG A 12 1210 UNP P0DTC2 SPIKE_SARS2 12 1210 DBREF 8YKG B 12 1210 UNP P0DTC2 SPIKE_SARS2 12 1210 DBREF 8YKG C 12 1210 UNP P0DTC2 SPIKE_SARS2 12 1210 DBREF 8YKG D 0 250 PDB 8YKG 8YKG 0 250 DBREF 8YKG F 0 250 PDB 8YKG 8YKG 0 250 SEQADV 8YKG GLY A 682 UNP P0DTC2 ARG 682 ENGINEERED MUTATION SEQADV 8YKG SER A 683 UNP P0DTC2 ARG 683 ENGINEERED MUTATION SEQADV 8YKG GLY A 685 UNP P0DTC2 ARG 685 ENGINEERED MUTATION SEQADV 8YKG PRO A 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 8YKG PRO A 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 8YKG PRO A 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 8YKG PRO A 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 8YKG PRO A 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 8YKG PRO A 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 8YKG GLY B 682 UNP P0DTC2 ARG 682 ENGINEERED MUTATION SEQADV 8YKG SER B 683 UNP P0DTC2 ARG 683 ENGINEERED MUTATION SEQADV 8YKG GLY B 685 UNP P0DTC2 ARG 685 ENGINEERED MUTATION SEQADV 8YKG PRO B 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 8YKG PRO B 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 8YKG PRO B 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 8YKG PRO B 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 8YKG PRO B 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 8YKG PRO B 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 8YKG GLY C 682 UNP P0DTC2 ARG 682 ENGINEERED MUTATION SEQADV 8YKG SER C 683 UNP P0DTC2 ARG 683 ENGINEERED MUTATION SEQADV 8YKG GLY C 685 UNP P0DTC2 ARG 685 ENGINEERED MUTATION SEQADV 8YKG PRO C 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 8YKG PRO C 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 8YKG PRO C 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 8YKG PRO C 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 8YKG PRO C 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 8YKG PRO C 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQRES 1 A 1199 SER SER GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU SEQRES 2 A 1199 PRO PRO ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR SEQRES 3 A 1199 TYR PRO ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER SEQRES 4 A 1199 THR GLN ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR SEQRES 5 A 1199 TRP PHE HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR SEQRES 6 A 1199 LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY SEQRES 7 A 1199 VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG SEQRES 8 A 1199 GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SEQRES 9 A 1199 SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE SEQRES 10 A 1199 LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU SEQRES 11 A 1199 GLY VAL TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SEQRES 12 A 1199 SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR SEQRES 13 A 1199 PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU SEQRES 14 A 1199 GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL SEQRES 15 A 1199 PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS SEQRES 16 A 1199 HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY SEQRES 17 A 1199 PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY SEQRES 18 A 1199 ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS SEQRES 19 A 1199 ARG SER TYR LEU THR PRO GLY ASP SER SER SER GLY TRP SEQRES 20 A 1199 THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN SEQRES 21 A 1199 PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR SEQRES 22 A 1199 ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER SEQRES 23 A 1199 GLU THR LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS SEQRES 24 A 1199 GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR SEQRES 25 A 1199 GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS SEQRES 26 A 1199 PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER SEQRES 27 A 1199 VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL SEQRES 28 A 1199 ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER PHE SER SEQRES 29 A 1199 THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN SEQRES 30 A 1199 ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL SEQRES 31 A 1199 ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN SEQRES 32 A 1199 THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP SEQRES 33 A 1199 ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN SEQRES 34 A 1199 LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR SEQRES 35 A 1199 ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG SEQRES 36 A 1199 ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER THR PRO SEQRES 37 A 1199 CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU SEQRES 38 A 1199 GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR SEQRES 39 A 1199 GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU SEQRES 40 A 1199 HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR SEQRES 41 A 1199 ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN SEQRES 42 A 1199 GLY LEU THR GLY THR GLY VAL LEU THR GLU SER ASN LYS SEQRES 43 A 1199 LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA SEQRES 44 A 1199 ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU SEQRES 45 A 1199 ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER SEQRES 46 A 1199 VAL ILE THR PRO GLY THR ASN THR SER ASN GLN VAL ALA SEQRES 47 A 1199 VAL LEU TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL SEQRES 48 A 1199 ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL SEQRES 49 A 1199 TYR SER THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY SEQRES 50 A 1199 CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU SEQRES 51 A 1199 CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR SEQRES 52 A 1199 GLN THR GLN THR ASN SER PRO GLY SER ALA GLY SER VAL SEQRES 53 A 1199 ALA SER GLN SER ILE ILE ALA TYR THR MET SER LEU GLY SEQRES 54 A 1199 ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA SEQRES 55 A 1199 ILE PRO THR ASN PHE THR ILE SER VAL THR THR GLU ILE SEQRES 56 A 1199 LEU PRO VAL SER MET THR LYS THR SER VAL ASP CYS THR SEQRES 57 A 1199 MET TYR ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU SEQRES 58 A 1199 LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG SEQRES 59 A 1199 ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR SEQRES 60 A 1199 GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR SEQRES 61 A 1199 PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN SEQRES 62 A 1199 ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO SEQRES 63 A 1199 ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP SEQRES 64 A 1199 ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP SEQRES 65 A 1199 ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN SEQRES 66 A 1199 GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET SEQRES 67 A 1199 ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE SEQRES 68 A 1199 THR SER GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN SEQRES 69 A 1199 ILE PRO PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY SEQRES 70 A 1199 ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS SEQRES 71 A 1199 LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE SEQRES 72 A 1199 GLN ASP SER LEU SER SER THR PRO SER ALA LEU GLY LYS SEQRES 73 A 1199 LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN SEQRES 74 A 1199 THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SEQRES 75 A 1199 SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO SEQRES 76 A 1199 PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY SEQRES 77 A 1199 ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU SEQRES 78 A 1199 ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA SEQRES 79 A 1199 ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS SEQRES 80 A 1199 ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER SEQRES 81 A 1199 PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS SEQRES 82 A 1199 VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR SEQRES 83 A 1199 ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO SEQRES 84 A 1199 ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE SEQRES 85 A 1199 VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR SEQRES 86 A 1199 THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL SEQRES 87 A 1199 ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN SEQRES 88 A 1199 PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR SEQRES 89 A 1199 PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP SEQRES 90 A 1199 ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS SEQRES 91 A 1199 GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN SEQRES 92 A 1199 GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU SEQRES 93 A 1199 GLN TYR ILE SEQRES 1 B 1199 SER SER GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU SEQRES 2 B 1199 PRO PRO ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR SEQRES 3 B 1199 TYR PRO ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER SEQRES 4 B 1199 THR GLN ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR SEQRES 5 B 1199 TRP PHE HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR SEQRES 6 B 1199 LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY SEQRES 7 B 1199 VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG SEQRES 8 B 1199 GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SEQRES 9 B 1199 SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE SEQRES 10 B 1199 LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU SEQRES 11 B 1199 GLY VAL TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SEQRES 12 B 1199 SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR SEQRES 13 B 1199 PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU SEQRES 14 B 1199 GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL SEQRES 15 B 1199 PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS SEQRES 16 B 1199 HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY SEQRES 17 B 1199 PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY SEQRES 18 B 1199 ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS SEQRES 19 B 1199 ARG SER TYR LEU THR PRO GLY ASP SER SER SER GLY TRP SEQRES 20 B 1199 THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN SEQRES 21 B 1199 PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR SEQRES 22 B 1199 ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER SEQRES 23 B 1199 GLU THR LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS SEQRES 24 B 1199 GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR SEQRES 25 B 1199 GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS SEQRES 26 B 1199 PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER SEQRES 27 B 1199 VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL SEQRES 28 B 1199 ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER PHE SER SEQRES 29 B 1199 THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN SEQRES 30 B 1199 ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL SEQRES 31 B 1199 ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN SEQRES 32 B 1199 THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP SEQRES 33 B 1199 ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN SEQRES 34 B 1199 LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR SEQRES 35 B 1199 ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG SEQRES 36 B 1199 ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER THR PRO SEQRES 37 B 1199 CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU SEQRES 38 B 1199 GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR SEQRES 39 B 1199 GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU SEQRES 40 B 1199 HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR SEQRES 41 B 1199 ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN SEQRES 42 B 1199 GLY LEU THR GLY THR GLY VAL LEU THR GLU SER ASN LYS SEQRES 43 B 1199 LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA SEQRES 44 B 1199 ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU SEQRES 45 B 1199 ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER SEQRES 46 B 1199 VAL ILE THR PRO GLY THR ASN THR SER ASN GLN VAL ALA SEQRES 47 B 1199 VAL LEU TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL SEQRES 48 B 1199 ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL SEQRES 49 B 1199 TYR SER THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY SEQRES 50 B 1199 CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU SEQRES 51 B 1199 CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR SEQRES 52 B 1199 GLN THR GLN THR ASN SER PRO GLY SER ALA GLY SER VAL SEQRES 53 B 1199 ALA SER GLN SER ILE ILE ALA TYR THR MET SER LEU GLY SEQRES 54 B 1199 ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA SEQRES 55 B 1199 ILE PRO THR ASN PHE THR ILE SER VAL THR THR GLU ILE SEQRES 56 B 1199 LEU PRO VAL SER MET THR LYS THR SER VAL ASP CYS THR SEQRES 57 B 1199 MET TYR ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU SEQRES 58 B 1199 LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG SEQRES 59 B 1199 ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR SEQRES 60 B 1199 GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR SEQRES 61 B 1199 PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN SEQRES 62 B 1199 ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO SEQRES 63 B 1199 ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP SEQRES 64 B 1199 ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP SEQRES 65 B 1199 ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN SEQRES 66 B 1199 GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET SEQRES 67 B 1199 ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE SEQRES 68 B 1199 THR SER GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN SEQRES 69 B 1199 ILE PRO PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY SEQRES 70 B 1199 ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS SEQRES 71 B 1199 LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE SEQRES 72 B 1199 GLN ASP SER LEU SER SER THR PRO SER ALA LEU GLY LYS SEQRES 73 B 1199 LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN SEQRES 74 B 1199 THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SEQRES 75 B 1199 SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO SEQRES 76 B 1199 PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY SEQRES 77 B 1199 ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU SEQRES 78 B 1199 ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA SEQRES 79 B 1199 ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS SEQRES 80 B 1199 ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER SEQRES 81 B 1199 PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS SEQRES 82 B 1199 VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR SEQRES 83 B 1199 ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO SEQRES 84 B 1199 ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE SEQRES 85 B 1199 VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR SEQRES 86 B 1199 THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL SEQRES 87 B 1199 ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN SEQRES 88 B 1199 PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR SEQRES 89 B 1199 PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP SEQRES 90 B 1199 ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS SEQRES 91 B 1199 GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN SEQRES 92 B 1199 GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU SEQRES 93 B 1199 GLN TYR ILE SEQRES 1 C 1199 SER SER GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU SEQRES 2 C 1199 PRO PRO ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR SEQRES 3 C 1199 TYR PRO ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER SEQRES 4 C 1199 THR GLN ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR SEQRES 5 C 1199 TRP PHE HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR SEQRES 6 C 1199 LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY SEQRES 7 C 1199 VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG SEQRES 8 C 1199 GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SEQRES 9 C 1199 SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE SEQRES 10 C 1199 LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU SEQRES 11 C 1199 GLY VAL TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SEQRES 12 C 1199 SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR SEQRES 13 C 1199 PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU SEQRES 14 C 1199 GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL SEQRES 15 C 1199 PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS SEQRES 16 C 1199 HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY SEQRES 17 C 1199 PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY SEQRES 18 C 1199 ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS SEQRES 19 C 1199 ARG SER TYR LEU THR PRO GLY ASP SER SER SER GLY TRP SEQRES 20 C 1199 THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN SEQRES 21 C 1199 PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR SEQRES 22 C 1199 ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER SEQRES 23 C 1199 GLU THR LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS SEQRES 24 C 1199 GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR SEQRES 25 C 1199 GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS SEQRES 26 C 1199 PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER SEQRES 27 C 1199 VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL SEQRES 28 C 1199 ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER PHE SER SEQRES 29 C 1199 THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN SEQRES 30 C 1199 ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL SEQRES 31 C 1199 ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN SEQRES 32 C 1199 THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP SEQRES 33 C 1199 ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN SEQRES 34 C 1199 LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR SEQRES 35 C 1199 ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG SEQRES 36 C 1199 ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER THR PRO SEQRES 37 C 1199 CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU SEQRES 38 C 1199 GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR SEQRES 39 C 1199 GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU SEQRES 40 C 1199 HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR SEQRES 41 C 1199 ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN SEQRES 42 C 1199 GLY LEU THR GLY THR GLY VAL LEU THR GLU SER ASN LYS SEQRES 43 C 1199 LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA SEQRES 44 C 1199 ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU SEQRES 45 C 1199 ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER SEQRES 46 C 1199 VAL ILE THR PRO GLY THR ASN THR SER ASN GLN VAL ALA SEQRES 47 C 1199 VAL LEU TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL SEQRES 48 C 1199 ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL SEQRES 49 C 1199 TYR SER THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY SEQRES 50 C 1199 CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU SEQRES 51 C 1199 CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR SEQRES 52 C 1199 GLN THR GLN THR ASN SER PRO GLY SER ALA GLY SER VAL SEQRES 53 C 1199 ALA SER GLN SER ILE ILE ALA TYR THR MET SER LEU GLY SEQRES 54 C 1199 ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA SEQRES 55 C 1199 ILE PRO THR ASN PHE THR ILE SER VAL THR THR GLU ILE SEQRES 56 C 1199 LEU PRO VAL SER MET THR LYS THR SER VAL ASP CYS THR SEQRES 57 C 1199 MET TYR ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU SEQRES 58 C 1199 LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG SEQRES 59 C 1199 ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR SEQRES 60 C 1199 GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR SEQRES 61 C 1199 PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN SEQRES 62 C 1199 ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO SEQRES 63 C 1199 ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP SEQRES 64 C 1199 ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP SEQRES 65 C 1199 ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN SEQRES 66 C 1199 GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET SEQRES 67 C 1199 ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE SEQRES 68 C 1199 THR SER GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN SEQRES 69 C 1199 ILE PRO PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY SEQRES 70 C 1199 ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS SEQRES 71 C 1199 LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE SEQRES 72 C 1199 GLN ASP SER LEU SER SER THR PRO SER ALA LEU GLY LYS SEQRES 73 C 1199 LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN SEQRES 74 C 1199 THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SEQRES 75 C 1199 SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO SEQRES 76 C 1199 PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY SEQRES 77 C 1199 ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU SEQRES 78 C 1199 ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA SEQRES 79 C 1199 ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS SEQRES 80 C 1199 ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER SEQRES 81 C 1199 PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS SEQRES 82 C 1199 VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR SEQRES 83 C 1199 ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO SEQRES 84 C 1199 ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE SEQRES 85 C 1199 VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR SEQRES 86 C 1199 THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL SEQRES 87 C 1199 ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN SEQRES 88 C 1199 PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR SEQRES 89 C 1199 PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP SEQRES 90 C 1199 ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS SEQRES 91 C 1199 GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN SEQRES 92 C 1199 GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU SEQRES 93 C 1199 GLN TYR ILE SEQRES 1 D 251 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 D 251 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 D 251 GLN SER VAL SER SER THR PHE LEU ALA TRP TYR GLN GLN SEQRES 4 D 251 LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 D 251 SER TYR MET ALA THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 D 251 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 D 251 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 D 251 TYR GLY SER SER LEU THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 D 251 GLU ILE LYS GLY GLY GLY GLY SER GLY GLY GLY GLY SER SEQRES 10 D 251 GLY GLY GLY GLY SER GLN VAL GLN LEU GLN GLN SER GLY SEQRES 11 D 251 PRO GLY LEU VAL LYS PRO SER GLN THR LEU SER LEU THR SEQRES 12 D 251 CYS SER ILE SER GLY ASP SER VAL SER SER ASN SER ALA SEQRES 13 D 251 ALA TRP ASN TRP ILE ARG GLN SER PRO SER ARG GLY LEU SEQRES 14 D 251 GLU TRP LEU GLY ARG THR TYR TYR ARG SER LYS TRP TYR SEQRES 15 D 251 ASN ASP TYR ALA GLY THR VAL LYS SER ARG ILE ALA ILE SEQRES 16 D 251 ASN PRO ASP THR SER LYS ASN GLN PHE SER LEU HIS LEU SEQRES 17 D 251 ASN SER VAL THR PRO GLU ASP THR ALA VAL TYR PHE CYS SEQRES 18 D 251 ALA ARG VAL ILE SER VAL ALA GLY TYR ALA PHE ASP ILE SEQRES 19 D 251 TRP GLY GLN GLY THR MET VAL THR VAL SER SER HIS HIS SEQRES 20 D 251 HIS HIS HIS HIS SEQRES 1 F 251 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 F 251 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 F 251 GLN SER VAL SER SER THR PHE LEU ALA TRP TYR GLN GLN SEQRES 4 F 251 LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 F 251 SER TYR MET ALA THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 F 251 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 F 251 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 F 251 TYR GLY SER SER LEU THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 F 251 GLU ILE LYS GLY GLY GLY GLY SER GLY GLY GLY GLY SER SEQRES 10 F 251 GLY GLY GLY GLY SER GLN VAL GLN LEU GLN GLN SER GLY SEQRES 11 F 251 PRO GLY LEU VAL LYS PRO SER GLN THR LEU SER LEU THR SEQRES 12 F 251 CYS SER ILE SER GLY ASP SER VAL SER SER ASN SER ALA SEQRES 13 F 251 ALA TRP ASN TRP ILE ARG GLN SER PRO SER ARG GLY LEU SEQRES 14 F 251 GLU TRP LEU GLY ARG THR TYR TYR ARG SER LYS TRP TYR SEQRES 15 F 251 ASN ASP TYR ALA GLY THR VAL LYS SER ARG ILE ALA ILE SEQRES 16 F 251 ASN PRO ASP THR SER LYS ASN GLN PHE SER LEU HIS LEU SEQRES 17 F 251 ASN SER VAL THR PRO GLU ASP THR ALA VAL TYR PHE CYS SEQRES 18 F 251 ALA ARG VAL ILE SER VAL ALA GLY TYR ALA PHE ASP ILE SEQRES 19 F 251 TRP GLY GLN GLY THR MET VAL THR VAL SER SER HIS HIS SEQRES 20 F 251 HIS HIS HIS HIS HET NAG E 1 14 HET NAG E 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG A1307 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 6 NAG 23(C8 H15 N O6) HELIX 1 AA1 ASP A 294 LYS A 304 1 11 HELIX 2 AA2 PRO A 337 ASN A 343 1 7 HELIX 3 AA3 TYR A 365 SER A 371 1 7 HELIX 4 AA4 ASP A 405 ILE A 410 5 6 HELIX 5 AA5 GLY A 416 ASN A 422 1 7 HELIX 6 AA6 ASP A 737 CYS A 743 1 7 HELIX 7 AA7 THR A 747 LEU A 754 1 8 HELIX 8 AA8 GLN A 755 GLY A 757 5 3 HELIX 9 AA9 SER A 758 ALA A 783 1 26 HELIX 10 AB1 SER A 816 VAL A 826 1 11 HELIX 11 AB2 THR A 866 GLY A 885 1 20 HELIX 12 AB3 TRP A 886 ALA A 890 5 5 HELIX 13 AB4 PRO A 897 GLY A 908 1 12 HELIX 14 AB5 GLN A 913 ASN A 919 1 7 HELIX 15 AB6 ASN A 919 THR A 941 1 23 HELIX 16 AB7 LEU A 945 GLN A 965 1 21 HELIX 17 AB8 LEU A 966 SER A 968 5 3 HELIX 18 AB9 VAL A 976 SER A 982 1 7 HELIX 19 AC1 ASP A 985 VAL A 1033 1 49 HELIX 20 AC2 ASP B 294 LYS B 304 1 11 HELIX 21 AC3 PRO B 337 ASN B 343 1 7 HELIX 22 AC4 SER B 349 TRP B 353 5 5 HELIX 23 AC5 TYR B 365 ASN B 370 1 6 HELIX 24 AC6 LYS B 386 ASP B 389 5 4 HELIX 25 AC7 ASP B 405 ILE B 410 5 6 HELIX 26 AC8 LYS B 417 ASN B 422 1 6 HELIX 27 AC9 GLY B 502 TYR B 505 5 4 HELIX 28 AD1 ASP B 737 GLY B 744 1 8 HELIX 29 AD2 SER B 746 LEU B 754 1 9 HELIX 30 AD3 GLN B 755 GLY B 757 5 3 HELIX 31 AD4 SER B 758 ALA B 783 1 26 HELIX 32 AD5 SER B 816 VAL B 826 1 11 HELIX 33 AD6 THR B 866 SER B 884 1 19 HELIX 34 AD7 TRP B 886 ALA B 890 5 5 HELIX 35 AD8 PRO B 897 GLY B 908 1 12 HELIX 36 AD9 THR B 912 THR B 941 1 30 HELIX 37 AE1 LEU B 945 GLN B 965 1 21 HELIX 38 AE2 LEU B 966 SER B 968 5 3 HELIX 39 AE3 VAL B 976 SER B 982 1 7 HELIX 40 AE4 ASP B 985 VAL B 1033 1 49 HELIX 41 AE5 ASP C 294 LYS C 304 1 11 HELIX 42 AE6 PRO C 337 ASN C 343 1 7 HELIX 43 AE7 SER C 349 TRP C 353 5 5 HELIX 44 AE8 ASP C 364 ASN C 370 1 7 HELIX 45 AE9 LYS C 386 LEU C 390 5 5 HELIX 46 AF1 ASP C 405 ILE C 410 5 6 HELIX 47 AF2 GLY C 416 ASN C 422 1 7 HELIX 48 AF3 GLY C 502 TYR C 505 5 4 HELIX 49 AF4 ASP C 737 GLY C 744 1 8 HELIX 50 AF5 SER C 746 LEU C 754 1 9 HELIX 51 AF6 GLN C 755 GLY C 757 5 3 HELIX 52 AF7 SER C 758 ALA C 783 1 26 HELIX 53 AF8 SER C 816 VAL C 826 1 11 HELIX 54 AF9 THR C 866 SER C 884 1 19 HELIX 55 AG1 TRP C 886 ALA C 890 5 5 HELIX 56 AG2 PRO C 897 GLY C 908 1 12 HELIX 57 AG3 GLN C 913 SER C 939 1 27 HELIX 58 AG4 LEU C 945 GLN C 965 1 21 HELIX 59 AG5 LEU C 966 SER C 968 5 3 HELIX 60 AG6 VAL C 976 LEU C 984 1 9 HELIX 61 AG7 ASP C 985 VAL C 1033 1 49 HELIX 62 AG8 VAL D 188 ILE D 192 5 5 HELIX 63 AG9 THR D 211 THR D 215 5 5 HELIX 64 AH1 SER D 225 GLY D 228 5 4 HELIX 65 AH2 GLY F 186 SER F 190 5 5 HELIX 66 AH3 THR F 211 THR F 215 5 5 HELIX 67 AH4 VAL F 226 GLY F 228 5 3 SHEET 1 AA1 8 THR A 29 SER A 31 0 SHEET 2 AA1 8 SER A 60 PHE A 65 -1 O SER A 60 N SER A 31 SHEET 3 AA1 8 TYR A 265 TYR A 269 -1 O TYR A 265 N PHE A 65 SHEET 4 AA1 8 VAL A 90 SER A 94 -1 N TYR A 91 O GLY A 268 SHEET 5 AA1 8 ARG A 190 ILE A 197 -1 O PHE A 192 N PHE A 92 SHEET 6 AA1 8 TYR A 200 LYS A 206 -1 O LYS A 202 N LYS A 195 SHEET 7 AA1 8 ALA A 222 PRO A 230 -1 O GLU A 224 N SER A 205 SHEET 8 AA1 8 VAL A 36 TYR A 37 1 N VAL A 36 O LEU A 223 SHEET 1 AA2 3 VAL A 47 PHE A 55 0 SHEET 2 AA2 3 GLN A 271 TYR A 279 -1 O GLN A 271 N PHE A 55 SHEET 3 AA2 3 ILE A 285 ASP A 287 -1 O THR A 286 N LYS A 278 SHEET 1 AA3 6 LEU A 84 PRO A 85 0 SHEET 2 AA3 6 ARG A 237 LEU A 241 -1 O PHE A 238 N LEU A 84 SHEET 3 AA3 6 GLY A 103 GLY A 107 -1 N ILE A 105 O GLN A 239 SHEET 4 AA3 6 LEU A 118 ASN A 121 -1 O ILE A 119 N TRP A 104 SHEET 5 AA3 6 VAL A 126 LYS A 129 -1 O VAL A 127 N VAL A 120 SHEET 6 AA3 6 GLU A 169 TYR A 170 -1 O TYR A 170 N ILE A 128 SHEET 1 AA4 5 GLY A 311 ARG A 319 0 SHEET 2 AA4 5 PHE A 592 THR A 599 -1 O VAL A 597 N TYR A 313 SHEET 3 AA4 5 ALA A 609 GLN A 613 -1 O ALA A 609 N ILE A 598 SHEET 4 AA4 5 GLY A 648 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 5 AA4 5 VAL A 642 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AA5 4 SER A 325 ARG A 328 0 SHEET 2 AA5 4 CYS A 538 PHE A 543 1 O ASN A 542 N ARG A 328 SHEET 3 AA5 4 LEU A 546 GLU A 554 -1 O GLY A 548 N PHE A 541 SHEET 4 AA5 4 LEU A 585 THR A 588 -1 O THR A 588 N VAL A 551 SHEET 1 AA6 5 ASN A 354 ILE A 358 0 SHEET 2 AA6 5 PHE A 392 ARG A 403 -1 O VAL A 395 N ILE A 358 SHEET 3 AA6 5 PRO A 507 LEU A 517 -1 O TYR A 508 N ILE A 402 SHEET 4 AA6 5 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 5 AA6 5 PHE A 374 CYS A 379 -1 N LYS A 378 O VAL A 433 SHEET 1 AA7 3 ASN A 354 ILE A 358 0 SHEET 2 AA7 3 PHE A 392 ARG A 403 -1 O VAL A 395 N ILE A 358 SHEET 3 AA7 3 ALA A 522 VAL A 524 -1 O VAL A 524 N PHE A 392 SHEET 1 AA8 2 LEU A 452 ARG A 454 0 SHEET 2 AA8 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AA9 2 PHE A 565 GLY A 566 0 SHEET 2 AA9 2 VAL B 42 PHE B 43 1 O PHE B 43 N PHE A 565 SHEET 1 AB1 4 GLU A 654 HIS A 655 0 SHEET 2 AB1 4 SER A 691 THR A 696 1 O ALA A 694 N GLU A 654 SHEET 3 AB1 4 ILE A 670 GLN A 675 -1 N SER A 673 O ILE A 693 SHEET 4 AB1 4 ILE A 664 GLY A 667 -1 N ILE A 666 O ILE A 670 SHEET 1 AB2 2 SER A 711 ALA A 713 0 SHEET 2 AB2 2 ASN A1074 THR A1076 -1 O PHE A1075 N ILE A 712 SHEET 1 AB3 3 ASN A 717 VAL A 722 0 SHEET 2 AB3 3 VAL A1065 GLN A1071 -1 O ALA A1070 N ASN A 717 SHEET 3 AB3 3 TYR A1047 MET A1050 -1 N MET A1050 O VAL A1065 SHEET 1 AB4 3 GLU A 725 PRO A 728 0 SHEET 2 AB4 3 GLY A1059 PHE A1062 -1 O PHE A1062 N GLU A 725 SHEET 3 AB4 3 PRO A1053 ALA A1056 -1 N GLN A1054 O VAL A1061 SHEET 1 AB5 2 THR A 734 VAL A 736 0 SHEET 2 AB5 2 LEU A 858 VAL A 860 -1 O THR A 859 N SER A 735 SHEET 1 AB6 2 LYS A1086 PRO A1090 0 SHEET 2 AB6 2 THR A1120 ASN A1125 -1 O PHE A1121 N PHE A1089 SHEET 1 AB7 3 VAL A1094 SER A1097 0 SHEET 2 AB7 3 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 3 AB7 3 GLN A1113 ILE A1114 -1 O GLN A1113 N VAL A1104 SHEET 1 AB8 8 TYR B 28 SER B 31 0 SHEET 2 AB8 8 SER B 60 HIS B 66 -1 O VAL B 62 N THR B 29 SHEET 3 AB8 8 ALA B 264 GLY B 268 -1 O TYR B 265 N PHE B 65 SHEET 4 AB8 8 VAL B 90 THR B 95 -1 N TYR B 91 O GLY B 268 SHEET 5 AB8 8 ASN B 188 ILE B 197 -1 O PHE B 194 N VAL B 90 SHEET 6 AB8 8 TYR B 200 PRO B 209 -1 O THR B 208 N LEU B 189 SHEET 7 AB8 8 ALA B 222 PRO B 230 -1 O LEU B 226 N ILE B 203 SHEET 8 AB8 8 VAL B 36 TYR B 37 1 N VAL B 36 O LEU B 223 SHEET 1 AB9 3 LEU B 48 PHE B 55 0 SHEET 2 AB9 3 GLN B 271 LYS B 278 -1 O GLN B 271 N PHE B 55 SHEET 3 AB9 3 ASP B 287 ASP B 290 -1 O ASP B 287 N LYS B 278 SHEET 1 AC1 4 LEU B 84 PRO B 85 0 SHEET 2 AC1 4 ARG B 237 LEU B 242 -1 O PHE B 238 N LEU B 84 SHEET 3 AC1 4 ILE B 101 PHE B 106 -1 N ILE B 105 O GLN B 239 SHEET 4 AC1 4 LEU B 117 ILE B 119 -1 O ILE B 119 N TRP B 104 SHEET 1 AC2 5 GLY B 311 ARG B 319 0 SHEET 2 AC2 5 PHE B 592 THR B 599 -1 O VAL B 597 N TYR B 313 SHEET 3 AC2 5 ALA B 609 GLN B 613 -1 O ALA B 609 N ILE B 598 SHEET 4 AC2 5 GLY B 648 ILE B 651 -1 O CYS B 649 N TYR B 612 SHEET 5 AC2 5 VAL B 642 GLN B 644 -1 N PHE B 643 O LEU B 650 SHEET 1 AC3 5 LYS B 356 ILE B 358 0 SHEET 2 AC3 5 VAL B 395 ARG B 403 -1 O ALA B 397 N LYS B 356 SHEET 3 AC3 5 PRO B 507 SER B 514 -1 O TYR B 508 N ILE B 402 SHEET 4 AC3 5 GLY B 431 ASN B 437 -1 N CYS B 432 O LEU B 513 SHEET 5 AC3 5 THR B 376 TYR B 380 -1 N LYS B 378 O VAL B 433 SHEET 1 AC4 3 CYS B 361 VAL B 362 0 SHEET 2 AC4 3 VAL B 524 CYS B 525 1 O CYS B 525 N CYS B 361 SHEET 3 AC4 3 CYS B 391 PHE B 392 -1 N PHE B 392 O VAL B 524 SHEET 1 AC5 2 LEU B 452 ARG B 454 0 SHEET 2 AC5 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AC6 6 CYS B 538 PHE B 543 0 SHEET 2 AC6 6 LEU B 546 GLU B 554 -1 O GLY B 550 N VAL B 539 SHEET 3 AC6 6 ILE B 584 THR B 588 -1 O ASP B 586 N THR B 553 SHEET 4 AC6 6 THR B 573 ARG B 577 -1 N VAL B 576 O LEU B 585 SHEET 5 AC6 6 PHE B 565 ARG B 567 -1 N GLY B 566 O ASP B 574 SHEET 6 AC6 6 VAL C 42 PHE C 43 1 O PHE C 43 N PHE B 565 SHEET 1 AC7 4 GLU B 654 TYR B 660 0 SHEET 2 AC7 4 SER B 691 MET B 697 1 O ILE B 692 N GLU B 654 SHEET 3 AC7 4 ILE B 670 GLN B 675 -1 N CYS B 671 O TYR B 695 SHEET 4 AC7 4 ILE B 664 GLY B 667 -1 N ILE B 666 O ILE B 670 SHEET 1 AC8 3 SER B 711 PRO B 728 0 SHEET 2 AC8 3 GLY B1059 THR B1077 -1 O ALA B1070 N ASN B 717 SHEET 3 AC8 3 MET B1050 ALA B1056 -1 N MET B1050 O VAL B1065 SHEET 1 AC9 5 SER B 711 PRO B 728 0 SHEET 2 AC9 5 GLY B1059 THR B1077 -1 O ALA B1070 N ASN B 717 SHEET 3 AC9 5 VAL B1094 SER B1097 -1 O SER B1097 N THR B1076 SHEET 4 AC9 5 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 5 AC9 5 GLN B1113 ILE B1114 -1 O GLN B1113 N VAL B1104 SHEET 1 AD1 2 THR B 734 VAL B 736 0 SHEET 2 AD1 2 LEU B 858 VAL B 860 -1 O THR B 859 N SER B 735 SHEET 1 AD2 2 ILE B1081 CYS B1082 0 SHEET 2 AD2 2 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AD3 2 LYS B1086 PRO B1090 0 SHEET 2 AD3 2 THR B1120 ASN B1125 -1 O PHE B1121 N PHE B1089 SHEET 1 AD4 8 TYR C 28 SER C 31 0 SHEET 2 AD4 8 SER C 60 HIS C 66 -1 O VAL C 62 N THR C 29 SHEET 3 AD4 8 ALA C 264 VAL C 267 -1 O VAL C 267 N THR C 63 SHEET 4 AD4 8 GLY C 89 SER C 94 -1 N ALA C 93 O TYR C 266 SHEET 5 AD4 8 LEU C 189 ILE C 197 -1 O PHE C 192 N PHE C 92 SHEET 6 AD4 8 TYR C 200 THR C 208 -1 O THR C 208 N LEU C 189 SHEET 7 AD4 8 ALA C 222 LEU C 229 -1 O LEU C 226 N ILE C 203 SHEET 8 AD4 8 VAL C 36 TYR C 37 1 N VAL C 36 O LEU C 223 SHEET 1 AD5 3 LEU C 48 PHE C 55 0 SHEET 2 AD5 3 GLN C 271 TYR C 279 -1 O LEU C 277 N HIS C 49 SHEET 3 AD5 3 ILE C 285 ASP C 290 -1 O ASP C 287 N LYS C 278 SHEET 1 AD6 6 LEU C 84 PRO C 85 0 SHEET 2 AD6 6 ARG C 237 THR C 240 -1 O PHE C 238 N LEU C 84 SHEET 3 AD6 6 TRP C 104 PHE C 106 -1 N ILE C 105 O GLN C 239 SHEET 4 AD6 6 LEU C 117 ILE C 119 -1 O ILE C 119 N TRP C 104 SHEET 5 AD6 6 ILE C 128 VAL C 130 -1 O LYS C 129 N LEU C 118 SHEET 6 AD6 6 PHE C 168 TYR C 170 -1 O TYR C 170 N ILE C 128 SHEET 1 AD7 5 GLY C 311 ARG C 319 0 SHEET 2 AD7 5 PHE C 592 THR C 599 -1 O VAL C 595 N THR C 315 SHEET 3 AD7 5 ALA C 609 GLN C 613 -1 O ALA C 609 N ILE C 598 SHEET 4 AD7 5 GLY C 648 ILE C 651 -1 O ILE C 651 N VAL C 610 SHEET 5 AD7 5 VAL C 642 THR C 645 -1 N PHE C 643 O LEU C 650 SHEET 1 AD8 5 ARG C 357 ILE C 358 0 SHEET 2 AD8 5 VAL C 395 ARG C 403 -1 O VAL C 395 N ILE C 358 SHEET 3 AD8 5 PRO C 507 LEU C 513 -1 O VAL C 512 N ASP C 398 SHEET 4 AD8 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AD8 5 THR C 376 TYR C 380 -1 N TYR C 380 O GLY C 431 SHEET 1 AD9 2 LEU C 452 ARG C 454 0 SHEET 2 AD9 2 LEU C 492 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AE1 5 CYS C 538 PHE C 543 0 SHEET 2 AE1 5 LEU C 546 GLU C 554 -1 O GLY C 550 N VAL C 539 SHEET 3 AE1 5 ILE C 584 THR C 588 -1 O THR C 588 N VAL C 551 SHEET 4 AE1 5 THR C 573 ARG C 577 -1 N ASP C 574 O ILE C 587 SHEET 5 AE1 5 PHE C 565 ARG C 567 -1 N GLY C 566 O ALA C 575 SHEET 1 AE2 4 GLU C 654 HIS C 655 0 SHEET 2 AE2 4 SER C 691 THR C 696 1 O ALA C 694 N GLU C 654 SHEET 3 AE2 4 ILE C 670 GLN C 675 -1 N SER C 673 O ILE C 693 SHEET 4 AE2 4 ILE C 664 GLY C 667 -1 N ILE C 666 O ILE C 670 SHEET 1 AE3 3 SER C 711 VAL C 722 0 SHEET 2 AE3 3 GLY C1059 THR C1077 -1 O ALA C1070 N ASN C 717 SHEET 3 AE3 3 TYR C1047 ALA C1056 -1 N LEU C1049 O VAL C1065 SHEET 1 AE4 4 GLU C 725 PRO C 728 0 SHEET 2 AE4 4 GLY C1059 THR C1077 -1 O PHE C1062 N GLU C 725 SHEET 3 AE4 4 VAL C1094 SER C1097 -1 O SER C1097 N THR C1076 SHEET 4 AE4 4 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 1 AE5 2 THR C 734 VAL C 736 0 SHEET 2 AE5 2 LEU C 858 VAL C 860 -1 O THR C 859 N SER C 735 SHEET 1 AE6 4 THR C1120 VAL C1122 0 SHEET 2 AE6 4 ALA C1087 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AE6 4 ILE C1081 CYS C1082 -1 N ILE C1081 O HIS C1088 SHEET 4 AE6 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AE7 4 LEU D 3 GLN D 5 0 SHEET 2 AE7 4 ALA D 18 ALA D 24 -1 O ARG D 23 N THR D 4 SHEET 3 AE7 4 ASP D 70 ILE D 75 -1 O PHE D 71 N CYS D 22 SHEET 4 AE7 4 PHE D 62 SER D 67 -1 N SER D 63 O THR D 74 SHEET 1 AE8 6 LEU D 10 LEU D 12 0 SHEET 2 AE8 6 THR D 101 ILE D 105 1 O GLU D 104 N LEU D 12 SHEET 3 AE8 6 ALA D 84 GLN D 89 -1 N ALA D 84 O LEU D 103 SHEET 4 AE8 6 ALA D 34 GLN D 38 -1 N ALA D 34 O GLN D 89 SHEET 5 AE8 6 ARG D 45 TYR D 49 -1 O LEU D 47 N TRP D 35 SHEET 6 AE8 6 TYR D 53 MET D 54 -1 O TYR D 53 N TYR D 49 SHEET 1 AE9 4 GLN D 124 SER D 128 0 SHEET 2 AE9 4 LEU D 139 SER D 146 -1 O SER D 144 N GLN D 126 SHEET 3 AE9 4 GLN D 202 LEU D 207 -1 O LEU D 207 N LEU D 139 SHEET 4 AE9 4 ALA D 193 ASP D 197 -1 N ALA D 193 O HIS D 206 SHEET 1 AF1 6 LEU D 132 VAL D 133 0 SHEET 2 AF1 6 THR D 238 VAL D 242 1 O THR D 241 N VAL D 133 SHEET 3 AF1 6 ALA D 216 VAL D 223 -1 N TYR D 218 O THR D 238 SHEET 4 AF1 6 ALA D 156 SER D 163 -1 N GLN D 162 O VAL D 217 SHEET 5 AF1 6 GLY D 167 TYR D 176 -1 O GLY D 172 N TRP D 159 SHEET 6 AF1 6 TRP D 180 TYR D 184 -1 O TYR D 181 N TYR D 175 SHEET 1 AF2 4 LEU D 132 VAL D 133 0 SHEET 2 AF2 4 THR D 238 VAL D 242 1 O THR D 241 N VAL D 133 SHEET 3 AF2 4 ALA D 216 VAL D 223 -1 N TYR D 218 O THR D 238 SHEET 4 AF2 4 PHE D 231 ILE D 233 -1 O ILE D 233 N ARG D 222 SHEET 1 AF3 4 LEU F 3 GLN F 5 0 SHEET 2 AF3 4 CYS F 22 ALA F 24 -1 O ARG F 23 N THR F 4 SHEET 3 AF3 4 ASP F 70 ILE F 75 -1 O PHE F 71 N CYS F 22 SHEET 4 AF3 4 ALA F 18 THR F 19 -1 N ALA F 18 O ILE F 75 SHEET 1 AF4 4 LEU F 3 GLN F 5 0 SHEET 2 AF4 4 CYS F 22 ALA F 24 -1 O ARG F 23 N THR F 4 SHEET 3 AF4 4 ASP F 70 ILE F 75 -1 O PHE F 71 N CYS F 22 SHEET 4 AF4 4 PHE F 62 SER F 67 -1 N SER F 63 O THR F 74 SHEET 1 AF5 6 THR F 9 LEU F 12 0 SHEET 2 AF5 6 THR F 101 ILE F 105 1 O LYS F 102 N LEU F 10 SHEET 3 AF5 6 ALA F 84 TYR F 86 -1 N TYR F 86 O THR F 101 SHEET 4 AF5 6 TRP F 35 GLN F 38 -1 N GLN F 38 O VAL F 85 SHEET 5 AF5 6 ARG F 45 TYR F 49 -1 O LEU F 47 N TRP F 35 SHEET 6 AF5 6 TYR F 53 MET F 54 -1 O TYR F 53 N TYR F 49 SHEET 1 AF6 4 GLN F 124 SER F 128 0 SHEET 2 AF6 4 LEU F 139 SER F 146 -1 O SER F 144 N GLN F 126 SHEET 3 AF6 4 GLN F 202 LEU F 207 -1 O LEU F 207 N LEU F 139 SHEET 4 AF6 4 ILE F 192 ASP F 197 -1 N ASP F 197 O GLN F 202 SHEET 1 AF7 6 LEU F 132 VAL F 133 0 SHEET 2 AF7 6 THR F 238 VAL F 242 1 O THR F 241 N VAL F 133 SHEET 3 AF7 6 ALA F 216 ILE F 224 -1 N ALA F 216 O VAL F 240 SHEET 4 AF7 6 ALA F 155 SER F 163 -1 N ILE F 160 O PHE F 219 SHEET 5 AF7 6 GLY F 167 TYR F 176 -1 O GLY F 167 N SER F 163 SHEET 6 AF7 6 TRP F 180 TYR F 184 -1 O TYR F 181 N TYR F 175 SHEET 1 AF8 4 LEU F 132 VAL F 133 0 SHEET 2 AF8 4 THR F 238 VAL F 242 1 O THR F 241 N VAL F 133 SHEET 3 AF8 4 ALA F 216 ILE F 224 -1 N ALA F 216 O VAL F 240 SHEET 4 AF8 4 PHE F 231 ILE F 233 -1 O ILE F 233 N ARG F 222 SSBOND 1 CYS A 131 CYS A 166 1555 1555 2.03 SSBOND 2 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 3 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 4 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 5 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 6 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 7 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 8 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 9 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 10 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 11 CYS A 1032 CYS A 1043 1555 1555 2.02 SSBOND 12 CYS A 1082 CYS A 1126 1555 1555 2.03 SSBOND 13 CYS B 131 CYS B 166 1555 1555 2.03 SSBOND 14 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 15 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 16 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 17 CYS B 391 CYS B 525 1555 1555 2.04 SSBOND 18 CYS B 480 CYS B 488 1555 1555 2.03 SSBOND 19 CYS B 538 CYS B 590 1555 1555 2.03 SSBOND 20 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 21 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 22 CYS B 738 CYS B 760 1555 1555 2.02 SSBOND 23 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 24 CYS B 1032 CYS B 1043 1555 1555 2.02 SSBOND 25 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 26 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 27 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 28 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 29 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 30 CYS C 391 CYS C 525 1555 1555 2.05 SSBOND 31 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 32 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 33 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 34 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 35 CYS C 738 CYS C 760 1555 1555 2.02 SSBOND 36 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 37 CYS C 1032 CYS C 1043 1555 1555 2.02 SSBOND 38 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 39 CYS D 22 CYS D 88 1555 1555 2.03 SSBOND 40 CYS D 143 CYS D 220 1555 1555 2.03 SSBOND 41 CYS F 22 CYS F 88 1555 1555 2.04 SSBOND 42 CYS F 143 CYS F 220 1555 1555 2.03 LINK ND2 ASN A 122 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 709 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG A1305 1555 1555 1.44 LINK ND2 ASN A1074 C1 NAG A1306 1555 1555 1.45 LINK ND2 ASN A1134 C1 NAG A1307 1555 1555 1.44 LINK ND2 ASN B 234 C1 NAG B1301 1555 1555 1.44 LINK ND2 ASN B 343 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1302 1555 1555 1.44 LINK ND2 ASN B 709 C1 NAG B1303 1555 1555 1.45 LINK ND2 ASN B 717 C1 NAG B1304 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG B1305 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG B1306 1555 1555 1.44 LINK ND2 ASN C 234 C1 NAG C1301 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG C1302 1555 1555 1.46 LINK ND2 ASN C 343 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 709 C1 NAG C1304 1555 1555 1.45 LINK ND2 ASN C 717 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG C1306 1555 1555 1.44 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000