HEADER VIRAL PROTEIN/IMMUNE SYSTEM 21-MAR-24 8YRO TITLE SARS-COV-2 DELTA SPIKE IN COMPLEX WITH JL-8C COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, D, P; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: JL-8C HEAVY CHAIN; COMPND 8 CHAIN: H, B, E; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: JL-8C LIGHT CHAIN; COMPND 12 CHAIN: L, C, F; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_TAXID: 2697049; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: EXPICHO; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 14 EXPRESSION_SYSTEM_CELL_LINE: EXPICHO; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_TAXID: 9606; SOURCE 18 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 20 EXPRESSION_SYSTEM_CELL_LINE: EXPICHO KEYWDS 3-UP, ANTIBODY, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR V.H.T.NGUYEN,X.CHEN JRNL AUTH X.CHEN,A.MOHAPATRA,H.T.V.NGUYEN,L.SCHIMANSKI,T.K.TAN, JRNL AUTH 2 P.RIJAL,C.P.CHEN,S.H.CHENG,W.H.LEE,Y.C.CHOU,A.R.TOWNSEND, JRNL AUTH 3 C.MA,K.A.HUANG JRNL TITL THE PRESENCE OF BROADLY NEUTRALIZING ANTI-SARS-COV-2 RBD JRNL TITL 2 ANTIBODIES ELICITED BY PRIMARY SERIES AND BOOSTER DOSE OF JRNL TITL 3 COVID-19 VACCINE JRNL REF PLOS PATHOG. 2024 JRNL REFN ESSN 1553-7374 JRNL DOI 10.1371/JOURNAL.PPAT.1012246 REMARK 2 REMARK 2 RESOLUTION. 3.27 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, CRYOSPARC, UCSF CHIMERA, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 8HHY REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.270 REMARK 3 NUMBER OF PARTICLES : 125930 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 8YRO COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ. REMARK 100 THE DEPOSITION ID IS D_1300046213. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV-2 DELTA SPIKE IN REMARK 245 COMPLEX WITH JL-8C REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.90 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 5264 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 52.43 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 105000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, D, P, H, L, B, C, E, F REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -5 REMARK 465 LYS A -4 REMARK 465 VAL A -3 REMARK 465 LYS A -2 REMARK 465 LEU A -1 REMARK 465 LEU A 0 REMARK 465 VAL A 1 REMARK 465 LEU A 2 REMARK 465 LEU A 3 REMARK 465 CYS A 4 REMARK 465 THR A 5 REMARK 465 PHE A 6 REMARK 465 THR A 7 REMARK 465 ALA A 8 REMARK 465 THR A 9 REMARK 465 TYR A 10 REMARK 465 ALA A 11 REMARK 465 GLY A 12 REMARK 465 THR A 13 REMARK 465 GLN A 14 REMARK 465 CYS A 15 REMARK 465 VAL A 16 REMARK 465 ASN A 17 REMARK 465 LEU A 18 REMARK 465 ARG A 19 REMARK 465 THR A 20 REMARK 465 ARG A 21 REMARK 465 THR A 22 REMARK 465 GLN A 23 REMARK 465 LEU A 24 REMARK 465 PRO A 25 REMARK 465 PRO A 26 REMARK 465 HIS A 69 REMARK 465 VAL A 70 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 76 REMARK 465 LYS A 77 REMARK 465 ARG A 78 REMARK 465 PHE A 79 REMARK 465 ALA A 123 REMARK 465 THR A 124 REMARK 465 VAL A 145 REMARK 465 TYR A 146 REMARK 465 TYR A 147 REMARK 465 HIS A 148 REMARK 465 LYS A 149 REMARK 465 ASN A 150 REMARK 465 ASN A 151 REMARK 465 LYS A 152 REMARK 465 SER A 153 REMARK 465 TRP A 154 REMARK 465 MET A 155 REMARK 465 GLU A 156 REMARK 465 SER A 157 REMARK 465 GLY A 158 REMARK 465 VAL A 159 REMARK 465 TYR A 160 REMARK 465 SER A 161 REMARK 465 SER A 162 REMARK 465 ALA A 163 REMARK 465 ASN A 164 REMARK 465 GLN A 173 REMARK 465 PRO A 174 REMARK 465 PHE A 175 REMARK 465 LEU A 176 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLN A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 ILE A 210 REMARK 465 ASN A 211 REMARK 465 LEU A 212 REMARK 465 VAL A 213 REMARK 465 ARG A 214 REMARK 465 ASP A 215 REMARK 465 LEU A 244 REMARK 465 HIS A 245 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 ALA A 262 REMARK 465 SER A 477 REMARK 465 LYS A 478 REMARK 465 PRO A 479 REMARK 465 PRO A 621 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 ASN A 679 REMARK 465 SER A 680 REMARK 465 ARG A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 GLY A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 THR A 827 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 SER A 937 REMARK 465 LEU A 938 REMARK 465 SER A 939 REMARK 465 SER A 940 REMARK 465 THR A 941 REMARK 465 ALA A 942 REMARK 465 SER A 943 REMARK 465 ALA A 944 REMARK 465 ARG A 1091 REMARK 465 GLU A 1092 REMARK 465 GLN A 1106 REMARK 465 ARG A 1107 REMARK 465 ASN A 1108 REMARK 465 GLU A 1144 REMARK 465 LEU A 1145 REMARK 465 ASP A 1146 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 ASP A 1209 REMARK 465 ILE A 1210 REMARK 465 ARG A 1211 REMARK 465 SER A 1212 REMARK 465 LEU A 1213 REMARK 465 VAL A 1214 REMARK 465 PRO A 1215 REMARK 465 ARG A 1216 REMARK 465 GLY A 1217 REMARK 465 SER A 1218 REMARK 465 PRO A 1219 REMARK 465 GLY A 1220 REMARK 465 SER A 1221 REMARK 465 GLY A 1222 REMARK 465 TYR A 1223 REMARK 465 ILE A 1224 REMARK 465 PRO A 1225 REMARK 465 GLU A 1226 REMARK 465 ALA A 1227 REMARK 465 PRO A 1228 REMARK 465 ARG A 1229 REMARK 465 ASP A 1230 REMARK 465 GLY A 1231 REMARK 465 GLN A 1232 REMARK 465 ALA A 1233 REMARK 465 TYR A 1234 REMARK 465 VAL A 1235 REMARK 465 ARG A 1236 REMARK 465 LYS A 1237 REMARK 465 ASP A 1238 REMARK 465 GLY A 1239 REMARK 465 GLU A 1240 REMARK 465 TRP A 1241 REMARK 465 VAL A 1242 REMARK 465 LEU A 1243 REMARK 465 LEU A 1244 REMARK 465 SER A 1245 REMARK 465 THR A 1246 REMARK 465 PHE A 1247 REMARK 465 LEU A 1248 REMARK 465 GLY A 1249 REMARK 465 HIS A 1250 REMARK 465 HIS A 1251 REMARK 465 HIS A 1252 REMARK 465 HIS A 1253 REMARK 465 HIS A 1254 REMARK 465 HIS A 1255 REMARK 465 MET D -5 REMARK 465 LYS D -4 REMARK 465 VAL D -3 REMARK 465 LYS D -2 REMARK 465 LEU D -1 REMARK 465 LEU D 0 REMARK 465 VAL D 1 REMARK 465 LEU D 2 REMARK 465 LEU D 3 REMARK 465 CYS D 4 REMARK 465 THR D 5 REMARK 465 PHE D 6 REMARK 465 THR D 7 REMARK 465 ALA D 8 REMARK 465 THR D 9 REMARK 465 TYR D 10 REMARK 465 ALA D 11 REMARK 465 GLY D 12 REMARK 465 THR D 13 REMARK 465 GLN D 14 REMARK 465 CYS D 15 REMARK 465 VAL D 16 REMARK 465 ASN D 17 REMARK 465 LEU D 18 REMARK 465 ARG D 19 REMARK 465 THR D 20 REMARK 465 ARG D 21 REMARK 465 THR D 22 REMARK 465 GLN D 23 REMARK 465 LEU D 24 REMARK 465 PRO D 25 REMARK 465 PRO D 26 REMARK 465 HIS D 69 REMARK 465 VAL D 70 REMARK 465 SER D 71 REMARK 465 GLY D 72 REMARK 465 THR D 73 REMARK 465 ASN D 74 REMARK 465 GLY D 75 REMARK 465 THR D 76 REMARK 465 LYS D 77 REMARK 465 THR D 124 REMARK 465 VAL D 145 REMARK 465 TYR D 146 REMARK 465 TYR D 147 REMARK 465 HIS D 148 REMARK 465 LYS D 149 REMARK 465 ASN D 150 REMARK 465 ASN D 151 REMARK 465 LYS D 152 REMARK 465 SER D 153 REMARK 465 TRP D 154 REMARK 465 MET D 155 REMARK 465 GLU D 156 REMARK 465 SER D 157 REMARK 465 GLY D 158 REMARK 465 VAL D 159 REMARK 465 TYR D 160 REMARK 465 SER D 161 REMARK 465 SER D 162 REMARK 465 ALA D 163 REMARK 465 ASN D 164 REMARK 465 GLN D 173 REMARK 465 PRO D 174 REMARK 465 PHE D 175 REMARK 465 LEU D 176 REMARK 465 MET D 177 REMARK 465 ASP D 178 REMARK 465 LEU D 179 REMARK 465 GLU D 180 REMARK 465 GLY D 181 REMARK 465 LYS D 182 REMARK 465 GLN D 183 REMARK 465 GLY D 184 REMARK 465 ASN D 185 REMARK 465 ARG D 246 REMARK 465 SER D 247 REMARK 465 TYR D 248 REMARK 465 LEU D 249 REMARK 465 THR D 250 REMARK 465 PRO D 251 REMARK 465 GLY D 252 REMARK 465 ASP D 253 REMARK 465 SER D 254 REMARK 465 SER D 255 REMARK 465 SER D 256 REMARK 465 GLY D 257 REMARK 465 TRP D 258 REMARK 465 THR D 259 REMARK 465 ALA D 260 REMARK 465 GLY D 261 REMARK 465 ALA D 262 REMARK 465 SER D 477 REMARK 465 LYS D 478 REMARK 465 PRO D 479 REMARK 465 CYS D 480 REMARK 465 ASN D 481 REMARK 465 GLY D 482 REMARK 465 VAL D 483 REMARK 465 GLU D 484 REMARK 465 GLY D 485 REMARK 465 PHE D 486 REMARK 465 PRO D 621 REMARK 465 VAL D 622 REMARK 465 ALA D 623 REMARK 465 ILE D 624 REMARK 465 HIS D 625 REMARK 465 ALA D 626 REMARK 465 ASP D 627 REMARK 465 GLN D 628 REMARK 465 LEU D 629 REMARK 465 THR D 630 REMARK 465 PRO D 631 REMARK 465 THR D 632 REMARK 465 TRP D 633 REMARK 465 ARG D 634 REMARK 465 VAL D 635 REMARK 465 TYR D 636 REMARK 465 SER D 637 REMARK 465 THR D 638 REMARK 465 GLY D 639 REMARK 465 GLN D 677 REMARK 465 THR D 678 REMARK 465 ASN D 679 REMARK 465 SER D 680 REMARK 465 ARG D 681 REMARK 465 GLY D 682 REMARK 465 SER D 683 REMARK 465 ALA D 684 REMARK 465 GLY D 685 REMARK 465 SER D 686 REMARK 465 VAL D 687 REMARK 465 ALA D 688 REMARK 465 SER D 708 REMARK 465 ASN D 709 REMARK 465 THR D 827 REMARK 465 LEU D 828 REMARK 465 ALA D 829 REMARK 465 ASP D 830 REMARK 465 ALA D 831 REMARK 465 GLY D 832 REMARK 465 PHE D 833 REMARK 465 ILE D 834 REMARK 465 LYS D 835 REMARK 465 GLN D 836 REMARK 465 TYR D 837 REMARK 465 GLY D 838 REMARK 465 ASP D 839 REMARK 465 CYS D 840 REMARK 465 LEU D 841 REMARK 465 GLY D 842 REMARK 465 ASP D 843 REMARK 465 ILE D 844 REMARK 465 ALA D 845 REMARK 465 ALA D 846 REMARK 465 ARG D 847 REMARK 465 ASP D 848 REMARK 465 LEU D 849 REMARK 465 ILE D 850 REMARK 465 CYS D 851 REMARK 465 ALA D 852 REMARK 465 GLN D 853 REMARK 465 ASP D 936 REMARK 465 SER D 937 REMARK 465 LEU D 938 REMARK 465 SER D 939 REMARK 465 SER D 940 REMARK 465 THR D 941 REMARK 465 ALA D 942 REMARK 465 SER D 943 REMARK 465 ALA D 944 REMARK 465 ALA D 1070 REMARK 465 GLN D 1071 REMARK 465 GLU D 1072 REMARK 465 GLU D 1092 REMARK 465 GLY D 1093 REMARK 465 ARG D 1107 REMARK 465 ASN D 1108 REMARK 465 GLN D 1142 REMARK 465 PRO D 1143 REMARK 465 GLU D 1144 REMARK 465 LEU D 1145 REMARK 465 ASP D 1146 REMARK 465 SER D 1147 REMARK 465 PHE D 1148 REMARK 465 LYS D 1149 REMARK 465 GLU D 1150 REMARK 465 GLU D 1151 REMARK 465 LEU D 1152 REMARK 465 ASP D 1153 REMARK 465 LYS D 1154 REMARK 465 TYR D 1155 REMARK 465 PHE D 1156 REMARK 465 LYS D 1157 REMARK 465 ASN D 1158 REMARK 465 HIS D 1159 REMARK 465 THR D 1160 REMARK 465 SER D 1161 REMARK 465 PRO D 1162 REMARK 465 ASP D 1163 REMARK 465 VAL D 1164 REMARK 465 ASP D 1165 REMARK 465 LEU D 1166 REMARK 465 GLY D 1167 REMARK 465 ASP D 1168 REMARK 465 ILE D 1169 REMARK 465 SER D 1170 REMARK 465 GLY D 1171 REMARK 465 ILE D 1172 REMARK 465 ASN D 1173 REMARK 465 ALA D 1174 REMARK 465 SER D 1175 REMARK 465 VAL D 1176 REMARK 465 VAL D 1177 REMARK 465 ASN D 1178 REMARK 465 ILE D 1179 REMARK 465 GLN D 1180 REMARK 465 LYS D 1181 REMARK 465 GLU D 1182 REMARK 465 ILE D 1183 REMARK 465 ASP D 1184 REMARK 465 ARG D 1185 REMARK 465 LEU D 1186 REMARK 465 ASN D 1187 REMARK 465 GLU D 1188 REMARK 465 VAL D 1189 REMARK 465 ALA D 1190 REMARK 465 LYS D 1191 REMARK 465 ASN D 1192 REMARK 465 LEU D 1193 REMARK 465 ASN D 1194 REMARK 465 GLU D 1195 REMARK 465 SER D 1196 REMARK 465 LEU D 1197 REMARK 465 ILE D 1198 REMARK 465 ASP D 1199 REMARK 465 LEU D 1200 REMARK 465 GLN D 1201 REMARK 465 GLU D 1202 REMARK 465 LEU D 1203 REMARK 465 GLY D 1204 REMARK 465 LYS D 1205 REMARK 465 TYR D 1206 REMARK 465 GLU D 1207 REMARK 465 GLN D 1208 REMARK 465 ASP D 1209 REMARK 465 ILE D 1210 REMARK 465 ARG D 1211 REMARK 465 SER D 1212 REMARK 465 LEU D 1213 REMARK 465 VAL D 1214 REMARK 465 PRO D 1215 REMARK 465 ARG D 1216 REMARK 465 GLY D 1217 REMARK 465 SER D 1218 REMARK 465 PRO D 1219 REMARK 465 GLY D 1220 REMARK 465 SER D 1221 REMARK 465 GLY D 1222 REMARK 465 TYR D 1223 REMARK 465 ILE D 1224 REMARK 465 PRO D 1225 REMARK 465 GLU D 1226 REMARK 465 ALA D 1227 REMARK 465 PRO D 1228 REMARK 465 ARG D 1229 REMARK 465 ASP D 1230 REMARK 465 GLY D 1231 REMARK 465 GLN D 1232 REMARK 465 ALA D 1233 REMARK 465 TYR D 1234 REMARK 465 VAL D 1235 REMARK 465 ARG D 1236 REMARK 465 LYS D 1237 REMARK 465 ASP D 1238 REMARK 465 GLY D 1239 REMARK 465 GLU D 1240 REMARK 465 TRP D 1241 REMARK 465 VAL D 1242 REMARK 465 LEU D 1243 REMARK 465 LEU D 1244 REMARK 465 SER D 1245 REMARK 465 THR D 1246 REMARK 465 PHE D 1247 REMARK 465 LEU D 1248 REMARK 465 GLY D 1249 REMARK 465 HIS D 1250 REMARK 465 HIS D 1251 REMARK 465 HIS D 1252 REMARK 465 HIS D 1253 REMARK 465 HIS D 1254 REMARK 465 HIS D 1255 REMARK 465 MET P -5 REMARK 465 LYS P -4 REMARK 465 VAL P -3 REMARK 465 LYS P -2 REMARK 465 LEU P -1 REMARK 465 LEU P 0 REMARK 465 VAL P 1 REMARK 465 LEU P 2 REMARK 465 LEU P 3 REMARK 465 CYS P 4 REMARK 465 THR P 5 REMARK 465 PHE P 6 REMARK 465 THR P 7 REMARK 465 ALA P 8 REMARK 465 THR P 9 REMARK 465 TYR P 10 REMARK 465 ALA P 11 REMARK 465 GLY P 12 REMARK 465 THR P 13 REMARK 465 GLN P 14 REMARK 465 CYS P 15 REMARK 465 VAL P 16 REMARK 465 ASN P 17 REMARK 465 LEU P 18 REMARK 465 ARG P 19 REMARK 465 THR P 20 REMARK 465 ARG P 21 REMARK 465 THR P 22 REMARK 465 GLN P 23 REMARK 465 LEU P 24 REMARK 465 PRO P 25 REMARK 465 PRO P 26 REMARK 465 HIS P 69 REMARK 465 VAL P 70 REMARK 465 SER P 71 REMARK 465 GLY P 72 REMARK 465 THR P 73 REMARK 465 ASN P 74 REMARK 465 GLY P 75 REMARK 465 THR P 76 REMARK 465 LYS P 77 REMARK 465 ARG P 78 REMARK 465 PHE P 79 REMARK 465 ALA P 123 REMARK 465 THR P 124 REMARK 465 TYR P 146 REMARK 465 TYR P 147 REMARK 465 HIS P 148 REMARK 465 LYS P 149 REMARK 465 ASN P 150 REMARK 465 ASN P 151 REMARK 465 LYS P 152 REMARK 465 SER P 153 REMARK 465 TRP P 154 REMARK 465 MET P 155 REMARK 465 GLU P 156 REMARK 465 SER P 157 REMARK 465 GLY P 158 REMARK 465 VAL P 159 REMARK 465 TYR P 160 REMARK 465 SER P 161 REMARK 465 SER P 162 REMARK 465 ALA P 163 REMARK 465 ASN P 164 REMARK 465 ASN P 165 REMARK 465 GLN P 173 REMARK 465 PRO P 174 REMARK 465 PHE P 175 REMARK 465 LEU P 176 REMARK 465 MET P 177 REMARK 465 ASP P 178 REMARK 465 LEU P 179 REMARK 465 GLU P 180 REMARK 465 GLY P 181 REMARK 465 LYS P 182 REMARK 465 GLN P 183 REMARK 465 GLY P 184 REMARK 465 ASN P 185 REMARK 465 LEU P 244 REMARK 465 HIS P 245 REMARK 465 ARG P 246 REMARK 465 SER P 247 REMARK 465 TYR P 248 REMARK 465 LEU P 249 REMARK 465 THR P 250 REMARK 465 PRO P 251 REMARK 465 GLY P 252 REMARK 465 ASP P 253 REMARK 465 SER P 254 REMARK 465 SER P 255 REMARK 465 SER P 256 REMARK 465 GLY P 257 REMARK 465 TRP P 258 REMARK 465 THR P 259 REMARK 465 ALA P 260 REMARK 465 GLY P 261 REMARK 465 ALA P 262 REMARK 465 GLY P 476 REMARK 465 SER P 477 REMARK 465 LYS P 478 REMARK 465 PRO P 479 REMARK 465 PRO P 527 REMARK 465 LYS P 528 REMARK 465 PRO P 621 REMARK 465 VAL P 622 REMARK 465 ALA P 623 REMARK 465 ILE P 624 REMARK 465 HIS P 625 REMARK 465 ALA P 626 REMARK 465 ASP P 627 REMARK 465 GLN P 628 REMARK 465 LEU P 629 REMARK 465 THR P 630 REMARK 465 PRO P 631 REMARK 465 THR P 632 REMARK 465 TRP P 633 REMARK 465 ARG P 634 REMARK 465 VAL P 635 REMARK 465 TYR P 636 REMARK 465 SER P 637 REMARK 465 THR P 638 REMARK 465 GLY P 639 REMARK 465 GLN P 677 REMARK 465 THR P 678 REMARK 465 ASN P 679 REMARK 465 SER P 680 REMARK 465 ARG P 681 REMARK 465 GLY P 682 REMARK 465 SER P 683 REMARK 465 ALA P 684 REMARK 465 GLY P 685 REMARK 465 SER P 686 REMARK 465 VAL P 687 REMARK 465 ALA P 688 REMARK 465 LYS P 786 REMARK 465 GLN P 787 REMARK 465 THR P 827 REMARK 465 LEU P 828 REMARK 465 ALA P 829 REMARK 465 ASP P 830 REMARK 465 ALA P 831 REMARK 465 GLY P 832 REMARK 465 PHE P 833 REMARK 465 ILE P 834 REMARK 465 LYS P 835 REMARK 465 GLN P 836 REMARK 465 TYR P 837 REMARK 465 GLY P 838 REMARK 465 ASP P 839 REMARK 465 CYS P 840 REMARK 465 LEU P 841 REMARK 465 GLY P 842 REMARK 465 ASP P 843 REMARK 465 ILE P 844 REMARK 465 ALA P 845 REMARK 465 ALA P 846 REMARK 465 ARG P 847 REMARK 465 ASP P 848 REMARK 465 LEU P 849 REMARK 465 ILE P 850 REMARK 465 CYS P 851 REMARK 465 ALA P 852 REMARK 465 GLN P 853 REMARK 465 THR P 866 REMARK 465 ASP P 867 REMARK 465 GLU P 868 REMARK 465 MET P 869 REMARK 465 ILE P 870 REMARK 465 GLY P 885 REMARK 465 TRP P 886 REMARK 465 THR P 887 REMARK 465 PHE P 888 REMARK 465 GLY P 889 REMARK 465 ALA P 890 REMARK 465 GLY P 891 REMARK 465 ALA P 892 REMARK 465 SER P 940 REMARK 465 THR P 941 REMARK 465 ALA P 942 REMARK 465 SER P 943 REMARK 465 ALA P 944 REMARK 465 PRO P 1090 REMARK 465 ARG P 1091 REMARK 465 GLU P 1092 REMARK 465 GLY P 1124 REMARK 465 LEU P 1141 REMARK 465 GLN P 1142 REMARK 465 PRO P 1143 REMARK 465 GLU P 1144 REMARK 465 LEU P 1145 REMARK 465 ASP P 1146 REMARK 465 SER P 1147 REMARK 465 PHE P 1148 REMARK 465 LYS P 1149 REMARK 465 GLU P 1150 REMARK 465 GLU P 1151 REMARK 465 LEU P 1152 REMARK 465 ASP P 1153 REMARK 465 LYS P 1154 REMARK 465 TYR P 1155 REMARK 465 PHE P 1156 REMARK 465 LYS P 1157 REMARK 465 ASN P 1158 REMARK 465 HIS P 1159 REMARK 465 THR P 1160 REMARK 465 SER P 1161 REMARK 465 PRO P 1162 REMARK 465 ASP P 1163 REMARK 465 VAL P 1164 REMARK 465 ASP P 1165 REMARK 465 LEU P 1166 REMARK 465 GLY P 1167 REMARK 465 ASP P 1168 REMARK 465 ILE P 1169 REMARK 465 SER P 1170 REMARK 465 GLY P 1171 REMARK 465 ILE P 1172 REMARK 465 ASN P 1173 REMARK 465 ALA P 1174 REMARK 465 SER P 1175 REMARK 465 VAL P 1176 REMARK 465 VAL P 1177 REMARK 465 ASN P 1178 REMARK 465 ILE P 1179 REMARK 465 GLN P 1180 REMARK 465 LYS P 1181 REMARK 465 GLU P 1182 REMARK 465 ILE P 1183 REMARK 465 ASP P 1184 REMARK 465 ARG P 1185 REMARK 465 LEU P 1186 REMARK 465 ASN P 1187 REMARK 465 GLU P 1188 REMARK 465 VAL P 1189 REMARK 465 ALA P 1190 REMARK 465 LYS P 1191 REMARK 465 ASN P 1192 REMARK 465 LEU P 1193 REMARK 465 ASN P 1194 REMARK 465 GLU P 1195 REMARK 465 SER P 1196 REMARK 465 LEU P 1197 REMARK 465 ILE P 1198 REMARK 465 ASP P 1199 REMARK 465 LEU P 1200 REMARK 465 GLN P 1201 REMARK 465 GLU P 1202 REMARK 465 LEU P 1203 REMARK 465 GLY P 1204 REMARK 465 LYS P 1205 REMARK 465 TYR P 1206 REMARK 465 GLU P 1207 REMARK 465 GLN P 1208 REMARK 465 ASP P 1209 REMARK 465 ILE P 1210 REMARK 465 ARG P 1211 REMARK 465 SER P 1212 REMARK 465 LEU P 1213 REMARK 465 VAL P 1214 REMARK 465 PRO P 1215 REMARK 465 ARG P 1216 REMARK 465 GLY P 1217 REMARK 465 SER P 1218 REMARK 465 PRO P 1219 REMARK 465 GLY P 1220 REMARK 465 SER P 1221 REMARK 465 GLY P 1222 REMARK 465 TYR P 1223 REMARK 465 ILE P 1224 REMARK 465 PRO P 1225 REMARK 465 GLU P 1226 REMARK 465 ALA P 1227 REMARK 465 PRO P 1228 REMARK 465 ARG P 1229 REMARK 465 ASP P 1230 REMARK 465 GLY P 1231 REMARK 465 GLN P 1232 REMARK 465 ALA P 1233 REMARK 465 TYR P 1234 REMARK 465 VAL P 1235 REMARK 465 ARG P 1236 REMARK 465 LYS P 1237 REMARK 465 ASP P 1238 REMARK 465 GLY P 1239 REMARK 465 GLU P 1240 REMARK 465 TRP P 1241 REMARK 465 VAL P 1242 REMARK 465 LEU P 1243 REMARK 465 LEU P 1244 REMARK 465 SER P 1245 REMARK 465 THR P 1246 REMARK 465 PHE P 1247 REMARK 465 LEU P 1248 REMARK 465 GLY P 1249 REMARK 465 HIS P 1250 REMARK 465 HIS P 1251 REMARK 465 HIS P 1252 REMARK 465 HIS P 1253 REMARK 465 HIS P 1254 REMARK 465 HIS P 1255 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS A 97 CG CD CE NZ REMARK 470 PHE A 140 CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR A 873 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ILE A 882 CG1 CG2 CD1 REMARK 470 PHE A 898 CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE A 906 CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR A 917 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 PHE A1109 CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE D 140 CG CD1 CD2 CE1 CE2 CZ REMARK 470 ASP D 142 CG OD1 OD2 REMARK 470 ARG D 214 CG CD NE CZ NH1 NH2 REMARK 470 PHE D 275 CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR D 917 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 PHE D1121 CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE P 140 CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE P 275 CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR P 873 CG CD1 CD2 CE1 CE2 CZ OH REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 CD1 ILE P 805 CG1 ILE P 818 1.18 REMARK 500 CG1 ILE P 805 CB ILE P 818 1.38 REMARK 500 O HIS H 110 O GLY H 111 1.54 REMARK 500 CG1 ILE P 805 CG1 ILE P 818 1.61 REMARK 500 O ALA A 363 CG PRO A 527 1.72 REMARK 500 O ILE P 805 OG SER P 816 1.72 REMARK 500 OG SER P 803 NE2 GLN P 935 1.89 REMARK 500 O ALA A 363 CD PRO A 527 1.93 REMARK 500 CD1 ILE P 805 CD1 ILE P 818 1.95 REMARK 500 O GLY P 799 N ASN P 801 2.04 REMARK 500 O GLN H 106 N GLY H 108 2.04 REMARK 500 CD2 LEU D 212 O ASP D 215 2.04 REMARK 500 O PHE P 800 N PHE P 802 2.04 REMARK 500 CD1 ILE P 805 CB ILE P 818 2.04 REMARK 500 SG CYS P 391 O VAL P 524 2.06 REMARK 500 O ASN A 331 N THR A 333 2.09 REMARK 500 C PHE P 800 N PHE P 802 2.09 REMARK 500 OG SER H 109 CD1 TYR L 55 2.09 REMARK 500 O GLY P 799 ND2 ASN P 801 2.18 REMARK 500 CG1 ILE P 805 CG2 ILE P 818 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A 131 CA - CB - SG ANGL. DEV. = 8.9 DEGREES REMARK 500 CYS A 166 CA - CB - SG ANGL. DEV. = 10.7 DEGREES REMARK 500 CYS A 361 CA - CB - SG ANGL. DEV. = 7.1 DEGREES REMARK 500 CYS A 617 CA - CB - SG ANGL. DEV. = 9.1 DEGREES REMARK 500 CYS A1082 CA - CB - SG ANGL. DEV. = 10.0 DEGREES REMARK 500 CYS A1126 CA - CB - SG ANGL. DEV. = 10.2 DEGREES REMARK 500 CYS D 131 CA - CB - SG ANGL. DEV. = 8.0 DEGREES REMARK 500 PHE P 802 N - CA - CB ANGL. DEV. = 13.6 DEGREES REMARK 500 ILE P 805 CA - C - O ANGL. DEV. = -12.6 DEGREES REMARK 500 CYS P1082 CA - CB - SG ANGL. DEV. = -12.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLN A 52 78.28 -105.58 REMARK 500 ARG A 102 44.33 -140.37 REMARK 500 ASN A 280 -167.02 -109.77 REMARK 500 ALA A 292 -11.34 -151.11 REMARK 500 ILE A 332 72.99 -46.77 REMARK 500 THR A 333 -105.66 -78.90 REMARK 500 ASN A 334 159.92 -36.54 REMARK 500 ALA A 352 75.07 -110.34 REMARK 500 PRO A 527 90.02 -66.76 REMARK 500 LYS A 528 -21.93 -163.99 REMARK 500 LYS A 529 -119.54 -130.22 REMARK 500 CYS A 617 50.03 -108.12 REMARK 500 VAL A 729 -51.99 -126.76 REMARK 500 ASP A 796 62.87 -100.06 REMARK 500 ASN A 801 87.27 -68.47 REMARK 500 THR A 883 -62.46 -95.72 REMARK 500 ASN A1074 110.87 -160.78 REMARK 500 PHE A1075 -162.03 -103.85 REMARK 500 PHE D 32 -71.74 -59.73 REMARK 500 ASN D 87 -61.97 -100.32 REMARK 500 ASN D 99 67.09 62.12 REMARK 500 SER D 112 16.81 55.77 REMARK 500 CYS D 136 -164.61 -112.17 REMARK 500 ILE D 332 -60.52 -121.64 REMARK 500 PHE D 338 -60.93 -97.63 REMARK 500 ALA D 352 39.19 -97.17 REMARK 500 ASN D 360 70.72 55.65 REMARK 500 SER D 438 43.44 -140.42 REMARK 500 VAL D 524 -32.45 -139.72 REMARK 500 THR D 531 -64.65 -94.16 REMARK 500 VAL D 729 -51.45 -126.53 REMARK 500 ASP D 796 59.90 -101.33 REMARK 500 PHE D 797 49.15 -93.49 REMARK 500 LEU D 984 -167.44 -117.91 REMARK 500 LEU D1049 -62.70 -96.12 REMARK 500 ALA D1078 95.95 -169.60 REMARK 500 ASP D1084 23.79 -146.97 REMARK 500 PRO D1090 -163.60 -79.64 REMARK 500 THR D1105 -159.10 -105.73 REMARK 500 CYS D1126 32.61 -140.73 REMARK 500 ASN P 81 71.28 56.57 REMARK 500 ASN P 87 -65.22 -90.13 REMARK 500 ARG P 102 44.39 -140.47 REMARK 500 CYS P 131 -167.43 -105.84 REMARK 500 CYS P 136 -162.99 -122.96 REMARK 500 ASN P 211 54.86 -91.59 REMARK 500 GLU P 324 -169.92 -125.61 REMARK 500 PRO P 337 49.87 -86.99 REMARK 500 ASP P 428 34.68 -98.89 REMARK 500 VAL P 524 96.20 -66.61 REMARK 500 REMARK 500 THIS ENTRY HAS 83 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-39546 RELATED DB: EMDB REMARK 900 SARS-COV-2 DELTA SPIKE IN COMPLEX WITH JL-8C DBREF 8YRO A 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 8YRO D 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 8YRO P 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 8YRO H 1 125 PDB 8YRO 8YRO 1 125 DBREF 8YRO L 1 118 PDB 8YRO 8YRO 1 118 DBREF 8YRO B 1 125 PDB 8YRO 8YRO 1 125 DBREF 8YRO C 1 118 PDB 8YRO 8YRO 1 118 DBREF 8YRO E 1 125 PDB 8YRO 8YRO 1 125 DBREF 8YRO F 1 118 PDB 8YRO 8YRO 1 118 SEQADV 8YRO MET A -5 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS A -4 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL A -3 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS A -2 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A -1 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A 0 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL A 1 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A 2 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A 3 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO CYS A 4 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR A 5 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PHE A 6 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR A 7 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA A 8 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR A 9 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR A 10 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA A 11 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY A 12 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR A 13 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG A 19 UNP P0DTC2 THR 19 VARIANT SEQADV 8YRO ASP A 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 8YRO A UNP P0DTC2 GLU 156 DELETION SEQADV 8YRO A UNP P0DTC2 PHE 157 DELETION SEQADV 8YRO GLY A 158 UNP P0DTC2 ARG 158 VARIANT SEQADV 8YRO ARG A 452 UNP P0DTC2 LEU 452 VARIANT SEQADV 8YRO LYS A 478 UNP P0DTC2 THR 478 VARIANT SEQADV 8YRO GLY A 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 8YRO ARG A 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 8YRO GLY A 682 UNP P0DTC2 ARG 682 VARIANT SEQADV 8YRO SER A 683 UNP P0DTC2 ARG 683 VARIANT SEQADV 8YRO GLY A 685 UNP P0DTC2 ARG 685 VARIANT SEQADV 8YRO ASN A 950 UNP P0DTC2 ASP 950 VARIANT SEQADV 8YRO PRO A 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 8YRO PRO A 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 8YRO ASP A 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ILE A 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG A 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER A 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ILE A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLU A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ASP A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLN A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ASP A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLU A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TRP A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PHE A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO MET D -5 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS D -4 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL D -3 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS D -2 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D -1 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D 0 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL D 1 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D 2 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D 3 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO CYS D 4 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR D 5 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PHE D 6 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR D 7 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA D 8 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR D 9 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR D 10 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA D 11 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY D 12 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR D 13 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG D 19 UNP P0DTC2 THR 19 VARIANT SEQADV 8YRO ASP D 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 8YRO D UNP P0DTC2 GLU 156 DELETION SEQADV 8YRO D UNP P0DTC2 PHE 157 DELETION SEQADV 8YRO GLY D 158 UNP P0DTC2 ARG 158 VARIANT SEQADV 8YRO ARG D 452 UNP P0DTC2 LEU 452 VARIANT SEQADV 8YRO LYS D 478 UNP P0DTC2 THR 478 VARIANT SEQADV 8YRO GLY D 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 8YRO ARG D 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 8YRO GLY D 682 UNP P0DTC2 ARG 682 VARIANT SEQADV 8YRO SER D 683 UNP P0DTC2 ARG 683 VARIANT SEQADV 8YRO GLY D 685 UNP P0DTC2 ARG 685 VARIANT SEQADV 8YRO ASN D 950 UNP P0DTC2 ASP 950 VARIANT SEQADV 8YRO PRO D 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 8YRO PRO D 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 8YRO ASP D 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ILE D 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG D 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER D 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL D 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO D 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG D 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY D 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER D 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO D 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY D 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER D 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY D 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR D 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ILE D 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO D 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLU D 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA D 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO D 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG D 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ASP D 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY D 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLN D 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA D 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR D 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL D 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG D 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS D 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ASP D 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY D 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLU D 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TRP D 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL D 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER D 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR D 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PHE D 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU D 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY D 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS D 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS D 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS D 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS D 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS D 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS D 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO MET P -5 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS P -4 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL P -3 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS P -2 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P -1 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P 0 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL P 1 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P 2 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P 3 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO CYS P 4 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR P 5 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PHE P 6 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR P 7 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA P 8 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR P 9 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR P 10 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA P 11 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY P 12 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR P 13 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG P 19 UNP P0DTC2 THR 19 VARIANT SEQADV 8YRO ASP P 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 8YRO P UNP P0DTC2 GLU 156 DELETION SEQADV 8YRO P UNP P0DTC2 PHE 157 DELETION SEQADV 8YRO GLY P 158 UNP P0DTC2 ARG 158 VARIANT SEQADV 8YRO ARG P 452 UNP P0DTC2 LEU 452 VARIANT SEQADV 8YRO LYS P 478 UNP P0DTC2 THR 478 VARIANT SEQADV 8YRO GLY P 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 8YRO ARG P 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 8YRO GLY P 682 UNP P0DTC2 ARG 682 VARIANT SEQADV 8YRO SER P 683 UNP P0DTC2 ARG 683 VARIANT SEQADV 8YRO GLY P 685 UNP P0DTC2 ARG 685 VARIANT SEQADV 8YRO ASN P 950 UNP P0DTC2 ASP 950 VARIANT SEQADV 8YRO PRO P 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 8YRO PRO P 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 8YRO ASP P 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ILE P 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG P 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER P 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL P 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO P 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG P 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY P 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER P 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO P 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY P 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER P 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY P 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR P 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ILE P 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO P 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLU P 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA P 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PRO P 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG P 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ASP P 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY P 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLN P 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ALA P 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TYR P 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL P 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ARG P 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LYS P 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO ASP P 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY P 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLU P 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO TRP P 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO VAL P 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO SER P 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO THR P 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO PHE P 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO LEU P 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO GLY P 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS P 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS P 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS P 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS P 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS P 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 8YRO HIS P 1255 UNP P0DTC2 EXPRESSION TAG SEQRES 1 A 1259 MET LYS VAL LYS LEU LEU VAL LEU LEU CYS THR PHE THR SEQRES 2 A 1259 ALA THR TYR ALA GLY THR GLN CYS VAL ASN LEU ARG THR SEQRES 3 A 1259 ARG THR GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR SEQRES 4 A 1259 ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER SEQRES 5 A 1259 VAL LEU HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SEQRES 6 A 1259 SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SER GLY SEQRES 7 A 1259 THR ASN GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO SEQRES 8 A 1259 PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER SEQRES 9 A 1259 ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SEQRES 10 A 1259 SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR SEQRES 11 A 1259 ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN SEQRES 12 A 1259 ASP PRO PHE LEU ASP VAL TYR TYR HIS LYS ASN ASN LYS SEQRES 13 A 1259 SER TRP MET GLU SER GLY VAL TYR SER SER ALA ASN ASN SEQRES 14 A 1259 CYS THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP SEQRES 15 A 1259 LEU GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU SEQRES 16 A 1259 PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SEQRES 17 A 1259 SER LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO SEQRES 18 A 1259 GLN GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO SEQRES 19 A 1259 ILE GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA SEQRES 20 A 1259 LEU HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER SEQRES 21 A 1259 GLY TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR SEQRES 22 A 1259 LEU GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN SEQRES 23 A 1259 GLY THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO SEQRES 24 A 1259 LEU SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL SEQRES 25 A 1259 GLU LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN SEQRES 26 A 1259 PRO THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN SEQRES 27 A 1259 LEU CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE SEQRES 28 A 1259 ALA SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN SEQRES 29 A 1259 CYS VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER SEQRES 30 A 1259 PHE SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS SEQRES 31 A 1259 LEU ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER SEQRES 32 A 1259 PHE VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO SEQRES 33 A 1259 GLY GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU SEQRES 34 A 1259 PRO ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER SEQRES 35 A 1259 ASN ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR SEQRES 36 A 1259 ARG TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE SEQRES 37 A 1259 GLU ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER SEQRES 38 A 1259 LYS PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE SEQRES 39 A 1259 PRO LEU GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL SEQRES 40 A 1259 GLY TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU SEQRES 41 A 1259 LEU LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SEQRES 42 A 1259 SER THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN SEQRES 43 A 1259 PHE ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER SEQRES 44 A 1259 ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP SEQRES 45 A 1259 ILE ALA ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR SEQRES 46 A 1259 LEU GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY SEQRES 47 A 1259 VAL SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN SEQRES 48 A 1259 VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS THR GLU VAL SEQRES 49 A 1259 PRO VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP SEQRES 50 A 1259 ARG VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG SEQRES 51 A 1259 ALA GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER SEQRES 52 A 1259 TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SEQRES 53 A 1259 SER TYR GLN THR GLN THR ASN SER ARG GLY SER ALA GLY SEQRES 54 A 1259 SER VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER SEQRES 55 A 1259 LEU GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER SEQRES 56 A 1259 ILE ALA ILE PRO THR ASN PHE THR ILE SER VAL THR THR SEQRES 57 A 1259 GLU ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP SEQRES 58 A 1259 CYS THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER SEQRES 59 A 1259 ASN LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU SEQRES 60 A 1259 ASN ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS SEQRES 61 A 1259 ASN THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR SEQRES 62 A 1259 LYS THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SEQRES 63 A 1259 SER GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SEQRES 64 A 1259 SER PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU SEQRES 65 A 1259 ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU SEQRES 66 A 1259 GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS SEQRES 67 A 1259 PHE ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP SEQRES 68 A 1259 GLU MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY SEQRES 69 A 1259 THR ILE THR SER GLY TRP THR PHE GLY ALA GLY ALA ALA SEQRES 70 A 1259 LEU GLN ILE PRO PHE ALA MET GLN MET ALA TYR ARG PHE SEQRES 71 A 1259 ASN GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN SEQRES 72 A 1259 GLN LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY SEQRES 73 A 1259 LYS ILE GLN ASP SER LEU SER SER THR ALA SER ALA LEU SEQRES 74 A 1259 GLY LYS LEU GLN ASN VAL VAL ASN GLN ASN ALA GLN ALA SEQRES 75 A 1259 LEU ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY SEQRES 76 A 1259 ALA ILE SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU SEQRES 77 A 1259 ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE SEQRES 78 A 1259 THR GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN SEQRES 79 A 1259 GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN SEQRES 80 A 1259 LEU ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SEQRES 81 A 1259 SER LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU SEQRES 82 A 1259 MET SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE SEQRES 83 A 1259 LEU HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE SEQRES 84 A 1259 THR THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS SEQRES 85 A 1259 PHE PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS SEQRES 86 A 1259 TRP PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE SEQRES 87 A 1259 ILE THR THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP SEQRES 88 A 1259 VAL VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO SEQRES 89 A 1259 LEU GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP SEQRES 90 A 1259 LYS TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU SEQRES 91 A 1259 GLY ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE SEQRES 92 A 1259 GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN SEQRES 93 A 1259 LEU ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS SEQRES 94 A 1259 TYR GLU GLN ASP ILE ARG SER LEU VAL PRO ARG GLY SER SEQRES 95 A 1259 PRO GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY SEQRES 96 A 1259 GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SEQRES 97 A 1259 SER THR PHE LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 D 1259 MET LYS VAL LYS LEU LEU VAL LEU LEU CYS THR PHE THR SEQRES 2 D 1259 ALA THR TYR ALA GLY THR GLN CYS VAL ASN LEU ARG THR SEQRES 3 D 1259 ARG THR GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR SEQRES 4 D 1259 ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER SEQRES 5 D 1259 VAL LEU HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SEQRES 6 D 1259 SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SER GLY SEQRES 7 D 1259 THR ASN GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO SEQRES 8 D 1259 PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER SEQRES 9 D 1259 ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SEQRES 10 D 1259 SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR SEQRES 11 D 1259 ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN SEQRES 12 D 1259 ASP PRO PHE LEU ASP VAL TYR TYR HIS LYS ASN ASN LYS SEQRES 13 D 1259 SER TRP MET GLU SER GLY VAL TYR SER SER ALA ASN ASN SEQRES 14 D 1259 CYS THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP SEQRES 15 D 1259 LEU GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU SEQRES 16 D 1259 PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SEQRES 17 D 1259 SER LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO SEQRES 18 D 1259 GLN GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO SEQRES 19 D 1259 ILE GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA SEQRES 20 D 1259 LEU HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER SEQRES 21 D 1259 GLY TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR SEQRES 22 D 1259 LEU GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN SEQRES 23 D 1259 GLY THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO SEQRES 24 D 1259 LEU SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL SEQRES 25 D 1259 GLU LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN SEQRES 26 D 1259 PRO THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN SEQRES 27 D 1259 LEU CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE SEQRES 28 D 1259 ALA SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN SEQRES 29 D 1259 CYS VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER SEQRES 30 D 1259 PHE SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS SEQRES 31 D 1259 LEU ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER SEQRES 32 D 1259 PHE VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO SEQRES 33 D 1259 GLY GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU SEQRES 34 D 1259 PRO ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER SEQRES 35 D 1259 ASN ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR SEQRES 36 D 1259 ARG TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE SEQRES 37 D 1259 GLU ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER SEQRES 38 D 1259 LYS PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE SEQRES 39 D 1259 PRO LEU GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL SEQRES 40 D 1259 GLY TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU SEQRES 41 D 1259 LEU LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SEQRES 42 D 1259 SER THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN SEQRES 43 D 1259 PHE ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER SEQRES 44 D 1259 ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP SEQRES 45 D 1259 ILE ALA ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR SEQRES 46 D 1259 LEU GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY SEQRES 47 D 1259 VAL SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN SEQRES 48 D 1259 VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS THR GLU VAL SEQRES 49 D 1259 PRO VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP SEQRES 50 D 1259 ARG VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG SEQRES 51 D 1259 ALA GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER SEQRES 52 D 1259 TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SEQRES 53 D 1259 SER TYR GLN THR GLN THR ASN SER ARG GLY SER ALA GLY SEQRES 54 D 1259 SER VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER SEQRES 55 D 1259 LEU GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER SEQRES 56 D 1259 ILE ALA ILE PRO THR ASN PHE THR ILE SER VAL THR THR SEQRES 57 D 1259 GLU ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP SEQRES 58 D 1259 CYS THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER SEQRES 59 D 1259 ASN LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU SEQRES 60 D 1259 ASN ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS SEQRES 61 D 1259 ASN THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR SEQRES 62 D 1259 LYS THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SEQRES 63 D 1259 SER GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SEQRES 64 D 1259 SER PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU SEQRES 65 D 1259 ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU SEQRES 66 D 1259 GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS SEQRES 67 D 1259 PHE ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP SEQRES 68 D 1259 GLU MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY SEQRES 69 D 1259 THR ILE THR SER GLY TRP THR PHE GLY ALA GLY ALA ALA SEQRES 70 D 1259 LEU GLN ILE PRO PHE ALA MET GLN MET ALA TYR ARG PHE SEQRES 71 D 1259 ASN GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN SEQRES 72 D 1259 GLN LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY SEQRES 73 D 1259 LYS ILE GLN ASP SER LEU SER SER THR ALA SER ALA LEU SEQRES 74 D 1259 GLY LYS LEU GLN ASN VAL VAL ASN GLN ASN ALA GLN ALA SEQRES 75 D 1259 LEU ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY SEQRES 76 D 1259 ALA ILE SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU SEQRES 77 D 1259 ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE SEQRES 78 D 1259 THR GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN SEQRES 79 D 1259 GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN SEQRES 80 D 1259 LEU ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SEQRES 81 D 1259 SER LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU SEQRES 82 D 1259 MET SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE SEQRES 83 D 1259 LEU HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE SEQRES 84 D 1259 THR THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS SEQRES 85 D 1259 PHE PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS SEQRES 86 D 1259 TRP PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE SEQRES 87 D 1259 ILE THR THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP SEQRES 88 D 1259 VAL VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO SEQRES 89 D 1259 LEU GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP SEQRES 90 D 1259 LYS TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU SEQRES 91 D 1259 GLY ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE SEQRES 92 D 1259 GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN SEQRES 93 D 1259 LEU ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS SEQRES 94 D 1259 TYR GLU GLN ASP ILE ARG SER LEU VAL PRO ARG GLY SER SEQRES 95 D 1259 PRO GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY SEQRES 96 D 1259 GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SEQRES 97 D 1259 SER THR PHE LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 P 1259 MET LYS VAL LYS LEU LEU VAL LEU LEU CYS THR PHE THR SEQRES 2 P 1259 ALA THR TYR ALA GLY THR GLN CYS VAL ASN LEU ARG THR SEQRES 3 P 1259 ARG THR GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR SEQRES 4 P 1259 ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER SEQRES 5 P 1259 VAL LEU HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SEQRES 6 P 1259 SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SER GLY SEQRES 7 P 1259 THR ASN GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO SEQRES 8 P 1259 PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER SEQRES 9 P 1259 ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SEQRES 10 P 1259 SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR SEQRES 11 P 1259 ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN SEQRES 12 P 1259 ASP PRO PHE LEU ASP VAL TYR TYR HIS LYS ASN ASN LYS SEQRES 13 P 1259 SER TRP MET GLU SER GLY VAL TYR SER SER ALA ASN ASN SEQRES 14 P 1259 CYS THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP SEQRES 15 P 1259 LEU GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU SEQRES 16 P 1259 PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SEQRES 17 P 1259 SER LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO SEQRES 18 P 1259 GLN GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO SEQRES 19 P 1259 ILE GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA SEQRES 20 P 1259 LEU HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER SEQRES 21 P 1259 GLY TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR SEQRES 22 P 1259 LEU GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN SEQRES 23 P 1259 GLY THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO SEQRES 24 P 1259 LEU SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL SEQRES 25 P 1259 GLU LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN SEQRES 26 P 1259 PRO THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN SEQRES 27 P 1259 LEU CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE SEQRES 28 P 1259 ALA SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN SEQRES 29 P 1259 CYS VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER SEQRES 30 P 1259 PHE SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS SEQRES 31 P 1259 LEU ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER SEQRES 32 P 1259 PHE VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO SEQRES 33 P 1259 GLY GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU SEQRES 34 P 1259 PRO ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER SEQRES 35 P 1259 ASN ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR SEQRES 36 P 1259 ARG TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE SEQRES 37 P 1259 GLU ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER SEQRES 38 P 1259 LYS PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE SEQRES 39 P 1259 PRO LEU GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL SEQRES 40 P 1259 GLY TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU SEQRES 41 P 1259 LEU LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SEQRES 42 P 1259 SER THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN SEQRES 43 P 1259 PHE ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER SEQRES 44 P 1259 ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP SEQRES 45 P 1259 ILE ALA ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR SEQRES 46 P 1259 LEU GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY SEQRES 47 P 1259 VAL SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN SEQRES 48 P 1259 VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS THR GLU VAL SEQRES 49 P 1259 PRO VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP SEQRES 50 P 1259 ARG VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG SEQRES 51 P 1259 ALA GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER SEQRES 52 P 1259 TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SEQRES 53 P 1259 SER TYR GLN THR GLN THR ASN SER ARG GLY SER ALA GLY SEQRES 54 P 1259 SER VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER SEQRES 55 P 1259 LEU GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER SEQRES 56 P 1259 ILE ALA ILE PRO THR ASN PHE THR ILE SER VAL THR THR SEQRES 57 P 1259 GLU ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP SEQRES 58 P 1259 CYS THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER SEQRES 59 P 1259 ASN LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU SEQRES 60 P 1259 ASN ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS SEQRES 61 P 1259 ASN THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR SEQRES 62 P 1259 LYS THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SEQRES 63 P 1259 SER GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SEQRES 64 P 1259 SER PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU SEQRES 65 P 1259 ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU SEQRES 66 P 1259 GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS SEQRES 67 P 1259 PHE ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP SEQRES 68 P 1259 GLU MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY SEQRES 69 P 1259 THR ILE THR SER GLY TRP THR PHE GLY ALA GLY ALA ALA SEQRES 70 P 1259 LEU GLN ILE PRO PHE ALA MET GLN MET ALA TYR ARG PHE SEQRES 71 P 1259 ASN GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN SEQRES 72 P 1259 GLN LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY SEQRES 73 P 1259 LYS ILE GLN ASP SER LEU SER SER THR ALA SER ALA LEU SEQRES 74 P 1259 GLY LYS LEU GLN ASN VAL VAL ASN GLN ASN ALA GLN ALA SEQRES 75 P 1259 LEU ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY SEQRES 76 P 1259 ALA ILE SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU SEQRES 77 P 1259 ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE SEQRES 78 P 1259 THR GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN SEQRES 79 P 1259 GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN SEQRES 80 P 1259 LEU ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SEQRES 81 P 1259 SER LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU SEQRES 82 P 1259 MET SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE SEQRES 83 P 1259 LEU HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE SEQRES 84 P 1259 THR THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS SEQRES 85 P 1259 PHE PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS SEQRES 86 P 1259 TRP PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE SEQRES 87 P 1259 ILE THR THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP SEQRES 88 P 1259 VAL VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO SEQRES 89 P 1259 LEU GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP SEQRES 90 P 1259 LYS TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU SEQRES 91 P 1259 GLY ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE SEQRES 92 P 1259 GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN SEQRES 93 P 1259 LEU ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS SEQRES 94 P 1259 TYR GLU GLN ASP ILE ARG SER LEU VAL PRO ARG GLY SER SEQRES 95 P 1259 PRO GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY SEQRES 96 P 1259 GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SEQRES 97 P 1259 SER THR PHE LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 H 121 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 121 PRO GLY GLU SER LEU LYS ILE SER CYS LYS GLY SER GLY SEQRES 3 H 121 TYR SER PHE THR SER HIS TRP ILE GLY TRP VAL ARG GLN SEQRES 4 H 121 LYS PRO GLY LYS GLY LEU GLU TRP VAL GLY ILE ILE HIS SEQRES 5 H 121 PRO TYR ASP SER ASP THR ARG TYR SER PRO SER PHE GLN SEQRES 6 H 121 GLY LEU VAL THR PHE SER ALA ASP LYS SER SER SER THR SEQRES 7 H 121 ALA TYR LEU GLN TRP SER SER LEU GLN ALA SER ASP THR SEQRES 8 H 121 ALA ILE TYR TYR CYS ALA ARG ARG THR ASP GLN TYR GLY SEQRES 9 H 121 SER HIS GLY MET ASP VAL TRP GLY GLN GLY THR THR VAL SEQRES 10 H 121 THR VAL SER SER SEQRES 1 L 110 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2 L 110 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3 L 110 SER ASN ILE GLY GLY ASN PRO VAL ASN TRP TYR GLN GLN SEQRES 4 L 110 LEU PRO ALA THR ALA PRO LYS LEU LEU ILE TYR ASN ASN SEQRES 5 L 110 ASN GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SEQRES 6 L 110 SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER GLY SEQRES 7 L 110 LEU GLN SER VAL ASP GLU ALA ASP TYR PHE CYS ALA ALA SEQRES 8 L 110 TRP ASP ASP SER LEU ASN GLY VAL LEU PHE GLY GLY GLY SEQRES 9 L 110 THR LYS LEU THR VAL LEU SEQRES 1 B 121 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 B 121 PRO GLY GLU SER LEU LYS ILE SER CYS LYS GLY SER GLY SEQRES 3 B 121 TYR SER PHE THR SER HIS TRP ILE GLY TRP VAL ARG GLN SEQRES 4 B 121 LYS PRO GLY LYS GLY LEU GLU TRP VAL GLY ILE ILE HIS SEQRES 5 B 121 PRO TYR ASP SER ASP THR ARG TYR SER PRO SER PHE GLN SEQRES 6 B 121 GLY LEU VAL THR PHE SER ALA ASP LYS SER SER SER THR SEQRES 7 B 121 ALA TYR LEU GLN TRP SER SER LEU GLN ALA SER ASP THR SEQRES 8 B 121 ALA ILE TYR TYR CYS ALA ARG ARG THR ASP GLN TYR GLY SEQRES 9 B 121 SER HIS GLY MET ASP VAL TRP GLY GLN GLY THR THR VAL SEQRES 10 B 121 THR VAL SER SER SEQRES 1 C 110 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2 C 110 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3 C 110 SER ASN ILE GLY GLY ASN PRO VAL ASN TRP TYR GLN GLN SEQRES 4 C 110 LEU PRO ALA THR ALA PRO LYS LEU LEU ILE TYR ASN ASN SEQRES 5 C 110 ASN GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SEQRES 6 C 110 SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER GLY SEQRES 7 C 110 LEU GLN SER VAL ASP GLU ALA ASP TYR PHE CYS ALA ALA SEQRES 8 C 110 TRP ASP ASP SER LEU ASN GLY VAL LEU PHE GLY GLY GLY SEQRES 9 C 110 THR LYS LEU THR VAL LEU SEQRES 1 E 121 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 E 121 PRO GLY GLU SER LEU LYS ILE SER CYS LYS GLY SER GLY SEQRES 3 E 121 TYR SER PHE THR SER HIS TRP ILE GLY TRP VAL ARG GLN SEQRES 4 E 121 LYS PRO GLY LYS GLY LEU GLU TRP VAL GLY ILE ILE HIS SEQRES 5 E 121 PRO TYR ASP SER ASP THR ARG TYR SER PRO SER PHE GLN SEQRES 6 E 121 GLY LEU VAL THR PHE SER ALA ASP LYS SER SER SER THR SEQRES 7 E 121 ALA TYR LEU GLN TRP SER SER LEU GLN ALA SER ASP THR SEQRES 8 E 121 ALA ILE TYR TYR CYS ALA ARG ARG THR ASP GLN TYR GLY SEQRES 9 E 121 SER HIS GLY MET ASP VAL TRP GLY GLN GLY THR THR VAL SEQRES 10 E 121 THR VAL SER SER SEQRES 1 F 110 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2 F 110 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3 F 110 SER ASN ILE GLY GLY ASN PRO VAL ASN TRP TYR GLN GLN SEQRES 4 F 110 LEU PRO ALA THR ALA PRO LYS LEU LEU ILE TYR ASN ASN SEQRES 5 F 110 ASN GLN ARG PRO SER GLY VAL SER ASP ARG PHE SER GLY SEQRES 6 F 110 SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER GLY SEQRES 7 F 110 LEU GLN SER VAL ASP GLU ALA ASP TYR PHE CYS ALA ALA SEQRES 8 F 110 TRP ASP ASP SER LEU ASN GLY VAL LEU PHE GLY GLY GLY SEQRES 9 F 110 THR LYS LEU THR VAL LEU HELIX 1 AA1 ASP A 294 LYS A 304 1 11 HELIX 2 AA2 PRO A 337 ASN A 343 1 7 HELIX 3 AA3 THR A 385 LEU A 390 1 6 HELIX 4 AA4 GLY A 416 TYR A 421 1 6 HELIX 5 AA5 SER A 438 SER A 443 1 6 HELIX 6 AA6 ASP A 737 ILE A 742 1 6 HELIX 7 AA7 SER A 746 GLN A 755 1 10 HELIX 8 AA8 PHE A 759 PHE A 782 1 24 HELIX 9 AA9 SER A 816 VAL A 826 1 11 HELIX 10 AB1 THR A 866 ALA A 871 1 6 HELIX 11 AB2 PRO A 897 PHE A 906 1 10 HELIX 12 AB3 ASN A 919 ASP A 936 1 18 HELIX 13 AB4 GLY A 946 GLN A 965 1 20 HELIX 14 AB5 LEU A 966 SER A 968 5 3 HELIX 15 AB6 VAL A 976 SER A 982 1 7 HELIX 16 AB7 ASP A 985 VAL A 1033 1 49 HELIX 17 AB8 ASP D 294 LYS D 304 1 11 HELIX 18 AB9 PHE D 338 ASN D 343 1 6 HELIX 19 AC1 GLY D 416 TYR D 421 1 6 HELIX 20 AC2 SER D 438 SER D 443 1 6 HELIX 21 AC3 ASP D 737 ILE D 742 1 6 HELIX 22 AC4 THR D 747 GLN D 755 1 9 HELIX 23 AC5 PHE D 759 PHE D 782 1 24 HELIX 24 AC6 SER D 816 VAL D 826 1 11 HELIX 25 AC7 THR D 866 GLY D 885 1 20 HELIX 26 AC8 TRP D 886 ALA D 890 5 5 HELIX 27 AC9 PRO D 897 GLY D 908 1 12 HELIX 28 AD1 ASN D 919 GLN D 935 1 17 HELIX 29 AD2 GLY D 946 GLN D 965 1 20 HELIX 30 AD3 LEU D 966 SER D 968 5 3 HELIX 31 AD4 VAL D 976 LEU D 984 1 9 HELIX 32 AD5 GLU D 988 CYS D 1032 1 45 HELIX 33 AD6 ASP P 294 LYS P 304 1 11 HELIX 34 AD7 PHE P 338 ASN P 343 1 6 HELIX 35 AD8 PRO P 384 ASN P 388 5 5 HELIX 36 AD9 GLY P 416 TYR P 421 1 6 HELIX 37 AE1 SER P 438 SER P 443 1 6 HELIX 38 AE2 ASP P 737 ILE P 742 1 6 HELIX 39 AE3 SER P 746 GLN P 755 1 10 HELIX 40 AE4 SER P 758 ALA P 783 1 26 HELIX 41 AE5 SER P 816 VAL P 826 1 11 HELIX 42 AE6 GLN P 872 THR P 883 1 12 HELIX 43 AE7 PRO P 897 GLY P 908 1 12 HELIX 44 AE8 GLN P 913 GLU P 918 1 6 HELIX 45 AE9 ASN P 919 SER P 939 1 21 HELIX 46 AF1 GLY P 946 LYS P 964 1 19 HELIX 47 AF2 GLN P 965 SER P 968 5 4 HELIX 48 AF3 LEU P 977 LEU P 984 1 8 HELIX 49 AF4 ASP P 985 CYS P 1032 1 48 HELIX 50 AF5 THR P 1116 THR P 1120 5 5 HELIX 51 AF6 GLN L 88 GLU L 92 5 5 HELIX 52 AF7 SER B 29 HIS B 33 5 5 HELIX 53 AF8 GLN C 88 GLU C 92 5 5 HELIX 54 AF9 GLN F 88 GLU F 92 5 5 SHEET 1 AA1 4 TYR A 28 SER A 31 0 SHEET 2 AA1 4 SER A 60 TRP A 64 -1 O VAL A 62 N THR A 29 SHEET 3 AA1 4 TYR A 265 VAL A 267 -1 O VAL A 267 N THR A 63 SHEET 4 AA1 4 ALA A 93 SER A 94 -1 N ALA A 93 O TYR A 266 SHEET 1 AA2 3 SER A 50 PHE A 55 0 SHEET 2 AA2 3 GLN A 271 TYR A 279 -1 O PHE A 275 N THR A 51 SHEET 3 AA2 3 ILE A 285 VAL A 289 -1 O VAL A 289 N LEU A 276 SHEET 1 AA3 3 LEU A 84 PRO A 85 0 SHEET 2 AA3 3 ARG A 237 LEU A 242 -1 O PHE A 238 N LEU A 84 SHEET 3 AA3 3 ILE A 101 PHE A 106 -1 N GLY A 103 O LEU A 241 SHEET 1 AA4 3 LEU A 118 VAL A 120 0 SHEET 2 AA4 3 VAL A 127 LYS A 129 -1 O VAL A 127 N VAL A 120 SHEET 3 AA4 3 GLU A 169 VAL A 171 -1 O TYR A 170 N ILE A 128 SHEET 1 AA5 4 ARG A 190 GLU A 191 0 SHEET 2 AA5 4 PHE A 194 ILE A 197 0 SHEET 3 AA5 4 TYR A 200 HIS A 207 -1 O LYS A 202 N LYS A 195 SHEET 4 AA5 4 GLU A 224 LEU A 229 -1 O LEU A 229 N PHE A 201 SHEET 1 AA6 4 GLY A 311 ARG A 319 0 SHEET 2 AA6 4 PHE A 592 THR A 599 -1 O GLY A 593 N PHE A 318 SHEET 3 AA6 4 ALA A 609 GLN A 613 -1 O ALA A 609 N ILE A 598 SHEET 4 AA6 4 GLY A 648 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 1 AA7 5 SER A 325 ARG A 328 0 SHEET 2 AA7 5 CYS A 538 PHE A 543 1 O ASN A 542 N ILE A 326 SHEET 3 AA7 5 GLY A 550 GLU A 554 -1 O GLY A 550 N VAL A 539 SHEET 4 AA7 5 ILE A 584 THR A 588 -1 O THR A 588 N VAL A 551 SHEET 5 AA7 5 ALA A 575 ARG A 577 -1 N VAL A 576 O LEU A 585 SHEET 1 AA8 5 ARG A 357 ILE A 358 0 SHEET 2 AA8 5 VAL A 395 ARG A 403 -1 O VAL A 395 N ILE A 358 SHEET 3 AA8 5 PRO A 507 PHE A 515 -1 O TYR A 508 N ILE A 402 SHEET 4 AA8 5 THR A 430 ASN A 437 -1 N THR A 430 O PHE A 515 SHEET 5 AA8 5 THR A 376 TYR A 380 -1 N TYR A 380 O GLY A 431 SHEET 1 AA9 2 ARG A 452 ARG A 454 0 SHEET 2 AA9 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AB1 2 PHE A 565 GLY A 566 0 SHEET 2 AB1 2 VAL D 42 PHE D 43 1 O PHE D 43 N PHE A 565 SHEET 1 AB2 4 GLU A 654 HIS A 655 0 SHEET 2 AB2 4 SER A 691 THR A 696 1 O ALA A 694 N GLU A 654 SHEET 3 AB2 4 ILE A 670 GLN A 675 -1 N CYS A 671 O TYR A 695 SHEET 4 AB2 4 ILE A 664 GLY A 667 -1 N ILE A 664 O ALA A 672 SHEET 1 AB3 2 GLU A 702 SER A 704 0 SHEET 2 AB3 2 ILE D 788 LYS D 790 1 O LYS D 790 N ASN A 703 SHEET 1 AB4 4 PHE A 718 PRO A 728 0 SHEET 2 AB4 4 TYR A1047 MET A1050 0 SHEET 3 AB4 4 PRO A1053 GLN A1054 0 SHEET 4 AB4 4 GLY A1059 PRO A1069 -1 N VAL A1061 O GLN A1054 SHEET 1 AB5 2 THR A 734 VAL A 736 0 SHEET 2 AB5 2 LEU A 858 VAL A 860 -1 O THR A 859 N SER A 735 SHEET 1 AB6 2 ILE A1081 CYS A1082 0 SHEET 2 AB6 2 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SHEET 1 AB7 2 HIS A1088 PHE A1089 0 SHEET 2 AB7 2 PHE A1121 VAL A1122 -1 O PHE A1121 N PHE A1089 SHEET 1 AB8 3 VAL A1094 SER A1097 0 SHEET 2 AB8 3 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 3 AB8 3 GLN A1113 ILE A1114 -1 O GLN A1113 N VAL A1104 SHEET 1 AB9 2 THR D 29 SER D 31 0 SHEET 2 AB9 2 SER D 60 VAL D 62 -1 O VAL D 62 N THR D 29 SHEET 1 AC1 3 SER D 50 PHE D 55 0 SHEET 2 AC1 3 GLN D 271 TYR D 279 -1 O GLN D 271 N PHE D 55 SHEET 3 AC1 3 ILE D 285 ASP D 290 -1 O VAL D 289 N LEU D 276 SHEET 1 AC2 5 LEU D 84 PRO D 85 0 SHEET 2 AC2 5 ARG D 237 LEU D 241 -1 O PHE D 238 N LEU D 84 SHEET 3 AC2 5 GLY D 103 GLY D 107 -1 N GLY D 103 O LEU D 241 SHEET 4 AC2 5 SER D 116 ASN D 121 -1 O LEU D 117 N PHE D 106 SHEET 5 AC2 5 VAL D 126 ILE D 128 -1 O VAL D 127 N VAL D 120 SHEET 1 AC3 6 VAL D 90 PHE D 92 0 SHEET 2 AC3 6 THR D 95 GLU D 96 0 SHEET 3 AC3 6 ASN D 188 PHE D 194 -1 O ASN D 188 N GLU D 96 SHEET 4 AC3 6 PHE D 201 PRO D 209 -1 O THR D 208 N LEU D 189 SHEET 5 AC3 6 PRO D 225 LEU D 229 -1 O LEU D 229 N PHE D 201 SHEET 6 AC3 6 VAL D 267 TYR D 269 -1 O GLY D 268 N TYR D 91 SHEET 1 AC4 4 GLY D 311 GLN D 314 0 SHEET 2 AC4 4 VAL D 595 THR D 599 -1 O VAL D 597 N TYR D 313 SHEET 3 AC4 4 ALA D 609 TYR D 612 -1 O ALA D 609 N ILE D 598 SHEET 4 AC4 4 LEU D 650 ILE D 651 -1 O ILE D 651 N VAL D 610 SHEET 1 AC5 2 PHE D 318 ARG D 319 0 SHEET 2 AC5 2 PHE D 592 GLY D 593 -1 O GLY D 593 N PHE D 318 SHEET 1 AC6 5 SER D 325 ARG D 328 0 SHEET 2 AC6 5 CYS D 538 PHE D 543 1 O ASN D 542 N ILE D 326 SHEET 3 AC6 5 LEU D 546 GLU D 554 -1 O LEU D 546 N PHE D 543 SHEET 4 AC6 5 ILE D 584 THR D 588 -1 O ASP D 586 N THR D 553 SHEET 5 AC6 5 ALA D 575 ARG D 577 -1 N VAL D 576 O LEU D 585 SHEET 1 AC7 5 ARG D 357 ILE D 358 0 SHEET 2 AC7 5 VAL D 395 ARG D 403 -1 O VAL D 395 N ILE D 358 SHEET 3 AC7 5 PRO D 507 PHE D 515 -1 O TYR D 508 N ILE D 402 SHEET 4 AC7 5 THR D 430 ASN D 437 -1 N TRP D 436 O ARG D 509 SHEET 5 AC7 5 THR D 376 TYR D 380 -1 N TYR D 380 O GLY D 431 SHEET 1 AC8 2 ARG D 452 ARG D 454 0 SHEET 2 AC8 2 LEU D 492 SER D 494 -1 O GLN D 493 N TYR D 453 SHEET 1 AC9 4 GLU D 654 HIS D 655 0 SHEET 2 AC9 4 SER D 691 THR D 696 1 O ALA D 694 N GLU D 654 SHEET 3 AC9 4 ILE D 670 GLN D 675 -1 N CYS D 671 O TYR D 695 SHEET 4 AC9 4 ILE D 664 GLY D 667 -1 N ILE D 664 O ALA D 672 SHEET 1 AD1 2 SER D 711 ALA D 713 0 SHEET 2 AD1 2 ASN D1074 THR D1076 -1 O PHE D1075 N ILE D 712 SHEET 1 AD2 4 THR D 719 PRO D 728 0 SHEET 2 AD2 4 TYR D1047 MET D1050 0 SHEET 3 AD2 4 PRO D1053 GLN D1054 0 SHEET 4 AD2 4 GLY D1059 VAL D1068 -1 O VAL D1061 N GLN D1054 SHEET 1 AD3 2 THR D 734 SER D 735 0 SHEET 2 AD3 2 THR D 859 VAL D 860 -1 O THR D 859 N SER D 735 SHEET 1 AD4 2 PHE D1095 SER D1097 0 SHEET 2 AD4 2 TRP D1102 VAL D1104 -1 O PHE D1103 N VAL D1096 SHEET 1 AD5 2 TYR P 28 SER P 31 0 SHEET 2 AD5 2 SER P 60 THR P 63 -1 O VAL P 62 N THR P 29 SHEET 1 AD6 3 SER P 50 GLN P 52 0 SHEET 2 AD6 3 THR P 274 TYR P 279 -1 O PHE P 275 N THR P 51 SHEET 3 AD6 3 ILE P 285 ASP P 290 -1 O VAL P 289 N LEU P 276 SHEET 1 AD7 3 LEU P 84 PRO P 85 0 SHEET 2 AD7 3 ARG P 237 LEU P 242 -1 O PHE P 238 N LEU P 84 SHEET 3 AD7 3 ILE P 101 ILE P 105 -1 N GLY P 103 O LEU P 241 SHEET 1 AD8 2 PHE P 92 SER P 94 0 SHEET 2 AD8 2 TYR P 265 VAL P 267 -1 O TYR P 266 N ALA P 93 SHEET 1 AD9 3 LEU P 118 VAL P 120 0 SHEET 2 AD9 3 VAL P 127 LYS P 129 -1 O LYS P 129 N LEU P 118 SHEET 3 AD9 3 GLU P 169 VAL P 171 -1 O TYR P 170 N ILE P 128 SHEET 1 AE1 3 ARG P 190 GLU P 191 0 SHEET 2 AE1 3 PHE P 201 HIS P 207 -1 O LYS P 206 N GLU P 191 SHEET 3 AE1 3 GLU P 224 LEU P 229 -1 O LEU P 229 N PHE P 201 SHEET 1 AE2 4 GLY P 311 GLN P 314 0 SHEET 2 AE2 4 SER P 596 THR P 599 -1 O THR P 599 N GLY P 311 SHEET 3 AE2 4 ALA P 609 LEU P 611 -1 O ALA P 609 N ILE P 598 SHEET 4 AE2 4 LEU P 650 ILE P 651 -1 O ILE P 651 N VAL P 610 SHEET 1 AE3 2 PHE P 318 ARG P 319 0 SHEET 2 AE3 2 PHE P 592 GLY P 593 -1 O GLY P 593 N PHE P 318 SHEET 1 AE4 4 SER P 325 ARG P 328 0 SHEET 2 AE4 4 CYS P 538 PHE P 543 1 O ASN P 542 N ILE P 326 SHEET 3 AE4 4 LEU P 546 GLU P 554 -1 O LEU P 546 N PHE P 543 SHEET 4 AE4 4 LEU P 585 THR P 588 -1 O THR P 588 N VAL P 551 SHEET 1 AE5 4 THR P 376 TYR P 380 0 SHEET 2 AE5 4 THR P 430 ASN P 437 -1 O GLY P 431 N TYR P 380 SHEET 3 AE5 4 PRO P 507 GLU P 516 -1 O PHE P 515 N THR P 430 SHEET 4 AE5 4 THR P 393 ARG P 403 -1 N ILE P 402 O TYR P 508 SHEET 1 AE6 2 ARG P 452 ARG P 454 0 SHEET 2 AE6 2 LEU P 492 SER P 494 -1 O GLN P 493 N TYR P 453 SHEET 1 AE7 4 GLU P 654 HIS P 655 0 SHEET 2 AE7 4 SER P 691 THR P 696 1 O ALA P 694 N GLU P 654 SHEET 3 AE7 4 ILE P 670 GLN P 675 -1 N CYS P 671 O TYR P 695 SHEET 4 AE7 4 ILE P 664 GLY P 667 -1 N ILE P 664 O ALA P 672 SHEET 1 AE8 7 SER P 711 THR P 719 0 SHEET 2 AE8 7 VAL P 722 PRO P 728 0 SHEET 3 AE8 7 TYR P1047 MET P1050 0 SHEET 4 AE8 7 PRO P1053 ALA P1056 0 SHEET 5 AE8 7 GLY P1059 THR P1077 -1 O VAL P1061 N GLN P1054 SHEET 6 AE8 7 VAL P1094 SER P1097 -1 O SER P1097 N THR P1076 SHEET 7 AE8 7 TRP P1102 THR P1105 -1 O THR P1105 N VAL P1094 SHEET 1 AE9 2 SER P 735 VAL P 736 0 SHEET 2 AE9 2 LEU P 858 THR P 859 -1 O THR P 859 N SER P 735 SHEET 1 AF1 4 GLN H 3 GLN H 6 0 SHEET 2 AF1 4 LEU H 19 SER H 26 -1 O LYS H 24 N VAL H 5 SHEET 3 AF1 4 THR H 82 TRP H 87 -1 O ALA H 83 N CYS H 23 SHEET 4 AF1 4 THR H 73 ASP H 77 -1 N SER H 75 O TYR H 84 SHEET 1 AF2 6 GLU H 11 VAL H 12 0 SHEET 2 AF2 6 THR H 119 THR H 122 1 O THR H 120 N GLU H 11 SHEET 3 AF2 6 ALA H 96 TYR H 99 -1 N TYR H 98 O THR H 119 SHEET 4 AF2 6 ILE H 35 GLN H 40 -1 N VAL H 38 O TYR H 99 SHEET 5 AF2 6 GLU H 47 HIS H 53 -1 O ILE H 52 N ILE H 35 SHEET 6 AF2 6 ASP H 60 TYR H 63 -1 O ASP H 60 N HIS H 53 SHEET 1 AF3 2 ALA H 101 ARG H 103 0 SHEET 2 AF3 2 MET H 112 TRP H 115 -1 O VAL H 114 N ARG H 102 SHEET 1 AF4 2 SER L 9 ALA L 11 0 SHEET 2 AF4 2 LYS L 114 LEU L 115 1 O LYS L 114 N ALA L 11 SHEET 1 AF5 3 ARG L 18 CYS L 23 0 SHEET 2 AF5 3 SER L 79 SER L 85 -1 O LEU L 82 N ILE L 21 SHEET 3 AF5 3 PHE L 69 SER L 76 -1 N SER L 70 O ALA L 83 SHEET 1 AF6 4 PRO L 50 ILE L 54 0 SHEET 2 AF6 4 ASN L 40 GLN L 44 -1 N TRP L 41 O LEU L 53 SHEET 3 AF6 4 ASP L 94 ASP L 101 -1 O ASP L 94 N GLN L 44 SHEET 4 AF6 4 GLY L 106 LEU L 108 -1 O GLY L 106 N ASP L 101 SHEET 1 AF7 4 GLN B 3 GLN B 6 0 SHEET 2 AF7 4 LEU B 19 SER B 26 -1 O LYS B 24 N VAL B 5 SHEET 3 AF7 4 THR B 82 TRP B 87 -1 O LEU B 85 N ILE B 21 SHEET 4 AF7 4 VAL B 72 ASP B 77 -1 N SER B 75 O TYR B 84 SHEET 1 AF8 3 GLU B 11 VAL B 12 0 SHEET 2 AF8 3 THR B 119 THR B 122 1 O THR B 120 N GLU B 11 SHEET 3 AF8 3 ALA B 96 TYR B 98 -1 N TYR B 98 O THR B 119 SHEET 1 AF9 3 ILE B 35 TRP B 37 0 SHEET 2 AF9 3 GLY B 50 HIS B 53 -1 O ILE B 52 N ILE B 35 SHEET 3 AF9 3 ASP B 60 TYR B 63 -1 O ASP B 60 N HIS B 53 SHEET 1 AG1 2 ALA B 101 ARG B 103 0 SHEET 2 AG1 2 MET B 112 TRP B 115 -1 O VAL B 114 N ARG B 102 SHEET 1 AG2 2 SER C 9 ALA C 11 0 SHEET 2 AG2 2 LYS C 114 LEU C 115 1 O LYS C 114 N ALA C 11 SHEET 1 AG3 3 VAL C 19 SER C 24 0 SHEET 2 AG3 3 SER C 79 ILE C 84 -1 O LEU C 82 N ILE C 21 SHEET 3 AG3 3 PHE C 69 SER C 76 -1 N SER C 70 O ALA C 83 SHEET 1 AG4 4 PRO C 50 ILE C 54 0 SHEET 2 AG4 4 ASN C 40 GLN C 44 -1 N TRP C 41 O LEU C 53 SHEET 3 AG4 4 ASP C 94 ASP C 101 -1 O PHE C 96 N TYR C 42 SHEET 4 AG4 4 GLY C 106 LEU C 108 -1 O GLY C 106 N ASP C 101 SHEET 1 AG5 4 GLN E 3 GLN E 6 0 SHEET 2 AG5 4 LEU E 19 SER E 26 -1 O LYS E 24 N VAL E 5 SHEET 3 AG5 4 THR E 82 TRP E 87 -1 O LEU E 85 N ILE E 21 SHEET 4 AG5 4 THR E 73 ASP E 77 -1 N SER E 75 O TYR E 84 SHEET 1 AG6 6 GLU E 11 VAL E 12 0 SHEET 2 AG6 6 THR E 119 THR E 122 1 O THR E 120 N GLU E 11 SHEET 3 AG6 6 ALA E 96 TYR E 99 -1 N TYR E 98 O THR E 119 SHEET 4 AG6 6 ILE E 35 GLN E 40 -1 N GLN E 40 O ILE E 97 SHEET 5 AG6 6 GLY E 50 HIS E 53 -1 O ILE E 52 N ILE E 35 SHEET 6 AG6 6 ASP E 60 TYR E 63 -1 O ASP E 60 N HIS E 53 SHEET 1 AG7 2 ALA E 101 ARG E 102 0 SHEET 2 AG7 2 VAL E 114 TRP E 115 -1 O VAL E 114 N ARG E 102 SHEET 1 AG8 4 LEU F 4 THR F 5 0 SHEET 2 AG8 4 ARG F 18 GLY F 25 -1 O SER F 24 N THR F 5 SHEET 3 AG8 4 SER F 79 SER F 85 -1 O LEU F 82 N ILE F 21 SHEET 4 AG8 4 PHE F 69 SER F 76 -1 N SER F 70 O ALA F 83 SHEET 1 AG9 2 SER F 9 ALA F 11 0 SHEET 2 AG9 2 LYS F 114 LEU F 115 1 O LYS F 114 N ALA F 11 SHEET 1 AH1 4 PRO F 50 ILE F 54 0 SHEET 2 AH1 4 ASN F 40 GLN F 44 -1 N TRP F 41 O LEU F 53 SHEET 3 AH1 4 ASP F 94 ASP F 101 -1 O PHE F 96 N TYR F 42 SHEET 4 AH1 4 GLY F 106 LEU F 108 -1 O GLY F 106 N ASP F 101 SSBOND 1 CYS A 131 CYS A 166 1555 1555 2.04 SSBOND 2 CYS A 291 CYS A 301 1555 1555 2.01 SSBOND 3 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 4 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 5 CYS A 391 CYS A 525 1555 1555 2.04 SSBOND 6 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 7 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 8 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 9 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 10 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 11 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 12 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 13 CYS A 1082 CYS A 1126 1555 1555 2.05 SSBOND 14 CYS D 131 CYS D 166 1555 1555 2.05 SSBOND 15 CYS D 291 CYS D 301 1555 1555 2.03 SSBOND 16 CYS D 336 CYS D 361 1555 1555 2.03 SSBOND 17 CYS D 379 CYS D 432 1555 1555 2.03 SSBOND 18 CYS D 538 CYS D 590 1555 1555 2.02 SSBOND 19 CYS D 617 CYS D 649 1555 1555 2.03 SSBOND 20 CYS D 662 CYS D 671 1555 1555 2.03 SSBOND 21 CYS D 738 CYS D 760 1555 1555 2.03 SSBOND 22 CYS D 743 CYS D 749 1555 1555 2.03 SSBOND 23 CYS D 1032 CYS D 1043 1555 1555 2.03 SSBOND 24 CYS D 1082 CYS D 1126 1555 1555 2.02 SSBOND 25 CYS P 131 CYS P 166 1555 1555 2.03 SSBOND 26 CYS P 291 CYS P 301 1555 1555 2.04 SSBOND 27 CYS P 336 CYS P 361 1555 1555 2.03 SSBOND 28 CYS P 379 CYS P 432 1555 1555 2.04 SSBOND 29 CYS P 480 CYS P 488 1555 1555 2.03 SSBOND 30 CYS P 538 CYS P 590 1555 1555 2.02 SSBOND 31 CYS P 617 CYS P 649 1555 1555 2.03 SSBOND 32 CYS P 662 CYS P 671 1555 1555 2.03 SSBOND 33 CYS P 738 CYS P 760 1555 1555 2.03 SSBOND 34 CYS P 743 CYS P 749 1555 1555 2.02 SSBOND 35 CYS P 1032 CYS P 1043 1555 1555 2.03 SSBOND 36 CYS P 1082 CYS P 1126 1555 1555 2.04 SSBOND 37 CYS H 23 CYS H 100 1555 1555 2.03 SSBOND 38 CYS L 23 CYS L 97 1555 1555 2.04 SSBOND 39 CYS B 23 CYS B 100 1555 1555 2.03 SSBOND 40 CYS C 23 CYS C 97 1555 1555 2.04 SSBOND 41 CYS E 23 CYS E 100 1555 1555 2.03 SSBOND 42 CYS F 23 CYS F 97 1555 1555 2.04 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000