HEADER VIRAL PROTEIN/IMMUNE SYSTEM 29-FEB-24 9AUI TITLE CRYO-EM STRUCTURE OF CH848.D949.10.17.GS-DH270.UCA4 COMPND MOL_ID: 1; COMPND 2 MOLECULE: HIV-1 BG505 DS-SOSIP GLYCOPROTEIN GP120; COMPND 3 CHAIN: A, B, C; COMPND 4 FRAGMENT: D949.GS-GP120; COMPND 5 SYNONYM: ENV POLYPROTEIN; COMPND 6 ENGINEERED: YES; COMPND 7 OTHER_DETAILS: D949.GS-GP120; COMPND 8 MOL_ID: 2; COMPND 9 MOLECULE: HIV-1 BG505 DS-SOSIP GLYCOPROTEIN GP41; COMPND 10 CHAIN: D, E, F; COMPND 11 FRAGMENT: UNP RESIDUES 509-661; COMPND 12 SYNONYM: ENV POLYPROTEIN; COMPND 13 ENGINEERED: YES; COMPND 14 OTHER_DETAILS: D949.GS-GP41; COMPND 15 MOL_ID: 3; COMPND 16 MOLECULE: UCA4 HEAVY CHAIN; COMPND 17 CHAIN: G, H, I; COMPND 18 ENGINEERED: YES; COMPND 19 MOL_ID: 4; COMPND 20 MOLECULE: UCA4 LIGHT CHAIN; COMPND 21 CHAIN: J, K, L; COMPND 22 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 GENE: ENV; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 9 ORGANISM_TAXID: 11676; SOURCE 10 GENE: ENV; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_TAXID: 9606; SOURCE 16 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 18 MOL_ID: 4; SOURCE 19 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 20 ORGANISM_TAXID: 9606; SOURCE 21 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS ENVELOPE, GLYCOPROTEIN, TRIMER, ANTIBODY, VIRAL PROTEIN, VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR Q.E.ZHANG,P.ACHARYA REVDAT 1 05-FEB-25 9AUI 0 JRNL AUTH O.M.SWANSON,Q.E.ZHANG,E.VAN ITALLIE,M.TIAN,A.R.BROWN, JRNL AUTH 2 C.HARRIS,A.B.KAPINGIDZA,B.RHODES,L.M.SMITH,S.VENKATAYOGI, JRNL AUTH 3 K.CRONIN,M.FRAZIER,R.PARKS,M.BAR,C.JIANG,J.S.MARTIN BEEM, JRNL AUTH 4 H.L.CHENG,J.DAVIS,K.MCGOVERN,A.NEWMAN,R.J.EDWARDS,D.CAIN, JRNL AUTH 5 S.M.ALAM,K.WIEHE,K.O.SAUNDERS,P.ACHARYA,F.ALT,B.F.HAYNES, JRNL AUTH 6 M.L.AZOITEI JRNL TITL AN ENGINEERED IMMUNOGEN ACTIVATES DIVERSE HIV BROADLY JRNL TITL 2 NEUTRALIZING ANTIBODY PRECURSORS AND PROMOTES ACQUISITION OF JRNL TITL 3 IMPROBABLE MUTATIONS. JRNL REF SCI TRANSL MED V. 17 R2218 2025 JRNL REFN ESSN 1946-6242 JRNL PMID 39772772 JRNL DOI 10.1126/SCITRANSLMED.ADR2218 REMARK 2 REMARK 2 RESOLUTION. 3.80 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, PHENIX, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.800 REMARK 3 NUMBER OF PARTICLES : 451469 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9AUI COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-MAR-24. REMARK 100 THE DEPOSITION ID IS D_1000282011. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF REMARK 245 CH848.D949.10.17.GS-DH270.UCA4 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.20 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 14195 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 350.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 5000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6640.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 81000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA A 31 REMARK 465 VAL A 506 REMARK 465 GLY A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 ALA B 31 REMARK 465 VAL B 506 REMARK 465 GLY B 507 REMARK 465 ARG B 508 REMARK 465 ARG B 509 REMARK 465 ARG B 510 REMARK 465 ARG B 511 REMARK 465 ARG B 512 REMARK 465 ARG B 513 REMARK 465 ALA C 31 REMARK 465 VAL C 506 REMARK 465 GLY C 507 REMARK 465 ARG C 508 REMARK 465 ARG C 509 REMARK 465 ARG C 510 REMARK 465 ARG C 511 REMARK 465 ARG C 512 REMARK 465 ARG C 513 REMARK 465 ALA D 512 REMARK 465 VAL D 513 REMARK 465 GLY D 514 REMARK 465 ILE D 515 REMARK 465 GLY D 516 REMARK 465 ALA D 517 REMARK 465 VAL D 518 REMARK 465 PHE D 519 REMARK 465 GLY D 547 REMARK 465 ILE D 548 REMARK 465 VAL D 549 REMARK 465 GLN D 550 REMARK 465 GLN D 551 REMARK 465 GLN D 552 REMARK 465 SER D 553 REMARK 465 ASN D 554 REMARK 465 LEU D 555 REMARK 465 LEU D 556 REMARK 465 ARG D 557 REMARK 465 ALA D 558 REMARK 465 PRO D 559 REMARK 465 GLU D 560 REMARK 465 ALA D 561 REMARK 465 GLN D 562 REMARK 465 GLN D 563 REMARK 465 HIS D 564 REMARK 465 LEU D 565 REMARK 465 LEU D 566 REMARK 465 LYS D 567 REMARK 465 LEU D 568 REMARK 465 ALA E 512 REMARK 465 VAL E 513 REMARK 465 GLY E 514 REMARK 465 ILE E 515 REMARK 465 GLY E 516 REMARK 465 ALA E 517 REMARK 465 VAL E 518 REMARK 465 PHE E 519 REMARK 465 GLY E 547 REMARK 465 ILE E 548 REMARK 465 VAL E 549 REMARK 465 GLN E 550 REMARK 465 GLN E 551 REMARK 465 GLN E 552 REMARK 465 SER E 553 REMARK 465 ASN E 554 REMARK 465 LEU E 555 REMARK 465 LEU E 556 REMARK 465 ARG E 557 REMARK 465 ALA E 558 REMARK 465 PRO E 559 REMARK 465 GLU E 560 REMARK 465 ALA E 561 REMARK 465 GLN E 562 REMARK 465 GLN E 563 REMARK 465 HIS E 564 REMARK 465 LEU E 565 REMARK 465 LEU E 566 REMARK 465 LYS E 567 REMARK 465 LEU E 568 REMARK 465 ALA F 512 REMARK 465 VAL F 513 REMARK 465 GLY F 514 REMARK 465 ILE F 515 REMARK 465 GLY F 516 REMARK 465 ALA F 517 REMARK 465 VAL F 518 REMARK 465 PHE F 519 REMARK 465 GLY F 547 REMARK 465 ILE F 548 REMARK 465 VAL F 549 REMARK 465 GLN F 550 REMARK 465 GLN F 551 REMARK 465 GLN F 552 REMARK 465 SER F 553 REMARK 465 ASN F 554 REMARK 465 LEU F 555 REMARK 465 LEU F 556 REMARK 465 ARG F 557 REMARK 465 ALA F 558 REMARK 465 PRO F 559 REMARK 465 GLU F 560 REMARK 465 ALA F 561 REMARK 465 GLN F 562 REMARK 465 GLN F 563 REMARK 465 HIS F 564 REMARK 465 LEU F 565 REMARK 465 LEU F 566 REMARK 465 LYS F 567 REMARK 465 LEU F 568 REMARK 465 SER G 127 REMARK 465 ALA G 128 REMARK 465 SER G 129 REMARK 465 THR G 130 REMARK 465 LYS G 131 REMARK 465 GLY G 132 REMARK 465 PRO G 133 REMARK 465 SER G 134 REMARK 465 VAL G 135 REMARK 465 PHE G 136 REMARK 465 PRO G 137 REMARK 465 LEU G 138 REMARK 465 ALA G 139 REMARK 465 PRO G 140 REMARK 465 SER G 141 REMARK 465 SER G 142 REMARK 465 LYS G 143 REMARK 465 SER G 144 REMARK 465 THR G 145 REMARK 465 SER G 146 REMARK 465 GLY G 147 REMARK 465 GLY G 148 REMARK 465 THR G 149 REMARK 465 ALA G 150 REMARK 465 ALA G 151 REMARK 465 LEU G 152 REMARK 465 GLY G 153 REMARK 465 CYS G 154 REMARK 465 LEU G 155 REMARK 465 VAL G 156 REMARK 465 LYS G 157 REMARK 465 ASP G 158 REMARK 465 TYR G 159 REMARK 465 PHE G 160 REMARK 465 PRO G 161 REMARK 465 GLU G 162 REMARK 465 PRO G 163 REMARK 465 VAL G 164 REMARK 465 THR G 165 REMARK 465 VAL G 166 REMARK 465 SER G 167 REMARK 465 TRP G 168 REMARK 465 ASN G 169 REMARK 465 SER G 170 REMARK 465 GLY G 171 REMARK 465 ALA G 172 REMARK 465 LEU G 173 REMARK 465 THR G 174 REMARK 465 SER G 175 REMARK 465 GLY G 176 REMARK 465 VAL G 177 REMARK 465 HIS G 178 REMARK 465 THR G 179 REMARK 465 PHE G 180 REMARK 465 PRO G 181 REMARK 465 ALA G 182 REMARK 465 VAL G 183 REMARK 465 LEU G 184 REMARK 465 GLN G 185 REMARK 465 SER G 186 REMARK 465 SER G 187 REMARK 465 GLY G 188 REMARK 465 LEU G 189 REMARK 465 TYR G 190 REMARK 465 SER G 191 REMARK 465 LEU G 192 REMARK 465 SER G 193 REMARK 465 SER G 194 REMARK 465 VAL G 195 REMARK 465 VAL G 196 REMARK 465 THR G 197 REMARK 465 VAL G 198 REMARK 465 PRO G 199 REMARK 465 SER G 200 REMARK 465 SER G 201 REMARK 465 SER G 202 REMARK 465 LEU G 203 REMARK 465 GLY G 204 REMARK 465 THR G 205 REMARK 465 GLN G 206 REMARK 465 THR G 207 REMARK 465 TYR G 208 REMARK 465 ILE G 209 REMARK 465 CYS G 210 REMARK 465 ASN G 211 REMARK 465 VAL G 212 REMARK 465 ASN G 213 REMARK 465 HIS G 214 REMARK 465 LYS G 215 REMARK 465 PRO G 216 REMARK 465 SER G 217 REMARK 465 ASN G 218 REMARK 465 THR G 219 REMARK 465 LYS G 220 REMARK 465 VAL G 221 REMARK 465 ASP G 222 REMARK 465 LYS G 223 REMARK 465 ARG G 224 REMARK 465 VAL G 225 REMARK 465 GLU G 226 REMARK 465 PRO G 227 REMARK 465 LYS G 228 REMARK 465 SER G 229 REMARK 465 CYS G 230 REMARK 465 ASP G 231 REMARK 465 LYS G 232 REMARK 465 SER H 127 REMARK 465 ALA H 128 REMARK 465 SER H 129 REMARK 465 THR H 130 REMARK 465 LYS H 131 REMARK 465 GLY H 132 REMARK 465 PRO H 133 REMARK 465 SER H 134 REMARK 465 VAL H 135 REMARK 465 PHE H 136 REMARK 465 PRO H 137 REMARK 465 LEU H 138 REMARK 465 ALA H 139 REMARK 465 PRO H 140 REMARK 465 SER H 141 REMARK 465 SER H 142 REMARK 465 LYS H 143 REMARK 465 SER H 144 REMARK 465 THR H 145 REMARK 465 SER H 146 REMARK 465 GLY H 147 REMARK 465 GLY H 148 REMARK 465 THR H 149 REMARK 465 ALA H 150 REMARK 465 ALA H 151 REMARK 465 LEU H 152 REMARK 465 GLY H 153 REMARK 465 CYS H 154 REMARK 465 LEU H 155 REMARK 465 VAL H 156 REMARK 465 LYS H 157 REMARK 465 ASP H 158 REMARK 465 TYR H 159 REMARK 465 PHE H 160 REMARK 465 PRO H 161 REMARK 465 GLU H 162 REMARK 465 PRO H 163 REMARK 465 VAL H 164 REMARK 465 THR H 165 REMARK 465 VAL H 166 REMARK 465 SER H 167 REMARK 465 TRP H 168 REMARK 465 ASN H 169 REMARK 465 SER H 170 REMARK 465 GLY H 171 REMARK 465 ALA H 172 REMARK 465 LEU H 173 REMARK 465 THR H 174 REMARK 465 SER H 175 REMARK 465 GLY H 176 REMARK 465 VAL H 177 REMARK 465 HIS H 178 REMARK 465 THR H 179 REMARK 465 PHE H 180 REMARK 465 PRO H 181 REMARK 465 ALA H 182 REMARK 465 VAL H 183 REMARK 465 LEU H 184 REMARK 465 GLN H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 GLY H 188 REMARK 465 LEU H 189 REMARK 465 TYR H 190 REMARK 465 SER H 191 REMARK 465 LEU H 192 REMARK 465 SER H 193 REMARK 465 SER H 194 REMARK 465 VAL H 195 REMARK 465 VAL H 196 REMARK 465 THR H 197 REMARK 465 VAL H 198 REMARK 465 PRO H 199 REMARK 465 SER H 200 REMARK 465 SER H 201 REMARK 465 SER H 202 REMARK 465 LEU H 203 REMARK 465 GLY H 204 REMARK 465 THR H 205 REMARK 465 GLN H 206 REMARK 465 THR H 207 REMARK 465 TYR H 208 REMARK 465 ILE H 209 REMARK 465 CYS H 210 REMARK 465 ASN H 211 REMARK 465 VAL H 212 REMARK 465 ASN H 213 REMARK 465 HIS H 214 REMARK 465 LYS H 215 REMARK 465 PRO H 216 REMARK 465 SER H 217 REMARK 465 ASN H 218 REMARK 465 THR H 219 REMARK 465 LYS H 220 REMARK 465 VAL H 221 REMARK 465 ASP H 222 REMARK 465 LYS H 223 REMARK 465 ARG H 224 REMARK 465 VAL H 225 REMARK 465 GLU H 226 REMARK 465 PRO H 227 REMARK 465 LYS H 228 REMARK 465 SER H 229 REMARK 465 CYS H 230 REMARK 465 ASP H 231 REMARK 465 LYS H 232 REMARK 465 SER I 127 REMARK 465 ALA I 128 REMARK 465 SER I 129 REMARK 465 THR I 130 REMARK 465 LYS I 131 REMARK 465 GLY I 132 REMARK 465 PRO I 133 REMARK 465 SER I 134 REMARK 465 VAL I 135 REMARK 465 PHE I 136 REMARK 465 PRO I 137 REMARK 465 LEU I 138 REMARK 465 ALA I 139 REMARK 465 PRO I 140 REMARK 465 SER I 141 REMARK 465 SER I 142 REMARK 465 LYS I 143 REMARK 465 SER I 144 REMARK 465 THR I 145 REMARK 465 SER I 146 REMARK 465 GLY I 147 REMARK 465 GLY I 148 REMARK 465 THR I 149 REMARK 465 ALA I 150 REMARK 465 ALA I 151 REMARK 465 LEU I 152 REMARK 465 GLY I 153 REMARK 465 CYS I 154 REMARK 465 LEU I 155 REMARK 465 VAL I 156 REMARK 465 LYS I 157 REMARK 465 ASP I 158 REMARK 465 TYR I 159 REMARK 465 PHE I 160 REMARK 465 PRO I 161 REMARK 465 GLU I 162 REMARK 465 PRO I 163 REMARK 465 VAL I 164 REMARK 465 THR I 165 REMARK 465 VAL I 166 REMARK 465 SER I 167 REMARK 465 TRP I 168 REMARK 465 ASN I 169 REMARK 465 SER I 170 REMARK 465 GLY I 171 REMARK 465 ALA I 172 REMARK 465 LEU I 173 REMARK 465 THR I 174 REMARK 465 SER I 175 REMARK 465 GLY I 176 REMARK 465 VAL I 177 REMARK 465 HIS I 178 REMARK 465 THR I 179 REMARK 465 PHE I 180 REMARK 465 PRO I 181 REMARK 465 ALA I 182 REMARK 465 VAL I 183 REMARK 465 LEU I 184 REMARK 465 GLN I 185 REMARK 465 SER I 186 REMARK 465 SER I 187 REMARK 465 GLY I 188 REMARK 465 LEU I 189 REMARK 465 TYR I 190 REMARK 465 SER I 191 REMARK 465 LEU I 192 REMARK 465 SER I 193 REMARK 465 SER I 194 REMARK 465 VAL I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 VAL I 198 REMARK 465 PRO I 199 REMARK 465 SER I 200 REMARK 465 SER I 201 REMARK 465 SER I 202 REMARK 465 LEU I 203 REMARK 465 GLY I 204 REMARK 465 THR I 205 REMARK 465 GLN I 206 REMARK 465 THR I 207 REMARK 465 TYR I 208 REMARK 465 ILE I 209 REMARK 465 CYS I 210 REMARK 465 ASN I 211 REMARK 465 VAL I 212 REMARK 465 ASN I 213 REMARK 465 HIS I 214 REMARK 465 LYS I 215 REMARK 465 PRO I 216 REMARK 465 SER I 217 REMARK 465 ASN I 218 REMARK 465 THR I 219 REMARK 465 LYS I 220 REMARK 465 VAL I 221 REMARK 465 ASP I 222 REMARK 465 LYS I 223 REMARK 465 ARG I 224 REMARK 465 VAL I 225 REMARK 465 GLU I 226 REMARK 465 PRO I 227 REMARK 465 LYS I 228 REMARK 465 SER I 229 REMARK 465 CYS I 230 REMARK 465 ASP I 231 REMARK 465 LYS I 232 REMARK 465 GLY J 111 REMARK 465 GLN J 112 REMARK 465 PRO J 113 REMARK 465 LYS J 114 REMARK 465 ALA J 115 REMARK 465 ASN J 116 REMARK 465 PRO J 117 REMARK 465 THR J 118 REMARK 465 VAL J 119 REMARK 465 THR J 120 REMARK 465 LEU J 121 REMARK 465 PHE J 122 REMARK 465 PRO J 123 REMARK 465 PRO J 124 REMARK 465 SER J 125 REMARK 465 SER J 126 REMARK 465 GLU J 127 REMARK 465 GLU J 128 REMARK 465 LEU J 129 REMARK 465 GLN J 130 REMARK 465 ALA J 131 REMARK 465 ASN J 132 REMARK 465 LYS J 133 REMARK 465 ALA J 134 REMARK 465 THR J 135 REMARK 465 LEU J 136 REMARK 465 VAL J 137 REMARK 465 CYS J 138 REMARK 465 LEU J 139 REMARK 465 ILE J 140 REMARK 465 SER J 141 REMARK 465 ASP J 142 REMARK 465 PHE J 143 REMARK 465 TYR J 144 REMARK 465 PRO J 145 REMARK 465 GLY J 146 REMARK 465 ALA J 147 REMARK 465 VAL J 148 REMARK 465 THR J 149 REMARK 465 VAL J 150 REMARK 465 ALA J 151 REMARK 465 TRP J 152 REMARK 465 LYS J 153 REMARK 465 ALA J 154 REMARK 465 ASP J 155 REMARK 465 SER J 156 REMARK 465 SER J 157 REMARK 465 PRO J 158 REMARK 465 VAL J 159 REMARK 465 LYS J 160 REMARK 465 ALA J 161 REMARK 465 GLY J 162 REMARK 465 VAL J 163 REMARK 465 GLU J 164 REMARK 465 THR J 165 REMARK 465 THR J 166 REMARK 465 THR J 167 REMARK 465 PRO J 168 REMARK 465 SER J 169 REMARK 465 LYS J 170 REMARK 465 GLN J 171 REMARK 465 SER J 172 REMARK 465 ASN J 173 REMARK 465 ASN J 174 REMARK 465 LYS J 175 REMARK 465 TYR J 176 REMARK 465 ALA J 177 REMARK 465 ALA J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 TYR J 181 REMARK 465 LEU J 182 REMARK 465 SER J 183 REMARK 465 LEU J 184 REMARK 465 THR J 185 REMARK 465 PRO J 186 REMARK 465 GLU J 187 REMARK 465 GLN J 188 REMARK 465 TRP J 189 REMARK 465 LYS J 190 REMARK 465 SER J 191 REMARK 465 HIS J 192 REMARK 465 ARG J 193 REMARK 465 SER J 194 REMARK 465 TYR J 195 REMARK 465 SER J 196 REMARK 465 CYS J 197 REMARK 465 GLN J 198 REMARK 465 VAL J 199 REMARK 465 THR J 200 REMARK 465 HIS J 201 REMARK 465 GLU J 202 REMARK 465 GLY J 203 REMARK 465 SER J 204 REMARK 465 THR J 205 REMARK 465 VAL J 206 REMARK 465 GLU J 207 REMARK 465 LYS J 208 REMARK 465 THR J 209 REMARK 465 VAL J 210 REMARK 465 ALA J 211 REMARK 465 PRO J 212 REMARK 465 THR J 213 REMARK 465 GLU J 214 REMARK 465 CYS J 215 REMARK 465 SER J 216 REMARK 465 GLY K 111 REMARK 465 GLN K 112 REMARK 465 PRO K 113 REMARK 465 LYS K 114 REMARK 465 ALA K 115 REMARK 465 ASN K 116 REMARK 465 PRO K 117 REMARK 465 THR K 118 REMARK 465 VAL K 119 REMARK 465 THR K 120 REMARK 465 LEU K 121 REMARK 465 PHE K 122 REMARK 465 PRO K 123 REMARK 465 PRO K 124 REMARK 465 SER K 125 REMARK 465 SER K 126 REMARK 465 GLU K 127 REMARK 465 GLU K 128 REMARK 465 LEU K 129 REMARK 465 GLN K 130 REMARK 465 ALA K 131 REMARK 465 ASN K 132 REMARK 465 LYS K 133 REMARK 465 ALA K 134 REMARK 465 THR K 135 REMARK 465 LEU K 136 REMARK 465 VAL K 137 REMARK 465 CYS K 138 REMARK 465 LEU K 139 REMARK 465 ILE K 140 REMARK 465 SER K 141 REMARK 465 ASP K 142 REMARK 465 PHE K 143 REMARK 465 TYR K 144 REMARK 465 PRO K 145 REMARK 465 GLY K 146 REMARK 465 ALA K 147 REMARK 465 VAL K 148 REMARK 465 THR K 149 REMARK 465 VAL K 150 REMARK 465 ALA K 151 REMARK 465 TRP K 152 REMARK 465 LYS K 153 REMARK 465 ALA K 154 REMARK 465 ASP K 155 REMARK 465 SER K 156 REMARK 465 SER K 157 REMARK 465 PRO K 158 REMARK 465 VAL K 159 REMARK 465 LYS K 160 REMARK 465 ALA K 161 REMARK 465 GLY K 162 REMARK 465 VAL K 163 REMARK 465 GLU K 164 REMARK 465 THR K 165 REMARK 465 THR K 166 REMARK 465 THR K 167 REMARK 465 PRO K 168 REMARK 465 SER K 169 REMARK 465 LYS K 170 REMARK 465 GLN K 171 REMARK 465 SER K 172 REMARK 465 ASN K 173 REMARK 465 ASN K 174 REMARK 465 LYS K 175 REMARK 465 TYR K 176 REMARK 465 ALA K 177 REMARK 465 ALA K 178 REMARK 465 SER K 179 REMARK 465 SER K 180 REMARK 465 TYR K 181 REMARK 465 LEU K 182 REMARK 465 SER K 183 REMARK 465 LEU K 184 REMARK 465 THR K 185 REMARK 465 PRO K 186 REMARK 465 GLU K 187 REMARK 465 GLN K 188 REMARK 465 TRP K 189 REMARK 465 LYS K 190 REMARK 465 SER K 191 REMARK 465 HIS K 192 REMARK 465 ARG K 193 REMARK 465 SER K 194 REMARK 465 TYR K 195 REMARK 465 SER K 196 REMARK 465 CYS K 197 REMARK 465 GLN K 198 REMARK 465 VAL K 199 REMARK 465 THR K 200 REMARK 465 HIS K 201 REMARK 465 GLU K 202 REMARK 465 GLY K 203 REMARK 465 SER K 204 REMARK 465 THR K 205 REMARK 465 VAL K 206 REMARK 465 GLU K 207 REMARK 465 LYS K 208 REMARK 465 THR K 209 REMARK 465 VAL K 210 REMARK 465 ALA K 211 REMARK 465 PRO K 212 REMARK 465 THR K 213 REMARK 465 GLU K 214 REMARK 465 CYS K 215 REMARK 465 SER K 216 REMARK 465 GLY L 111 REMARK 465 GLN L 112 REMARK 465 PRO L 113 REMARK 465 LYS L 114 REMARK 465 ALA L 115 REMARK 465 ASN L 116 REMARK 465 PRO L 117 REMARK 465 THR L 118 REMARK 465 VAL L 119 REMARK 465 THR L 120 REMARK 465 LEU L 121 REMARK 465 PHE L 122 REMARK 465 PRO L 123 REMARK 465 PRO L 124 REMARK 465 SER L 125 REMARK 465 SER L 126 REMARK 465 GLU L 127 REMARK 465 GLU L 128 REMARK 465 LEU L 129 REMARK 465 GLN L 130 REMARK 465 ALA L 131 REMARK 465 ASN L 132 REMARK 465 LYS L 133 REMARK 465 ALA L 134 REMARK 465 THR L 135 REMARK 465 LEU L 136 REMARK 465 VAL L 137 REMARK 465 CYS L 138 REMARK 465 LEU L 139 REMARK 465 ILE L 140 REMARK 465 SER L 141 REMARK 465 ASP L 142 REMARK 465 PHE L 143 REMARK 465 TYR L 144 REMARK 465 PRO L 145 REMARK 465 GLY L 146 REMARK 465 ALA L 147 REMARK 465 VAL L 148 REMARK 465 THR L 149 REMARK 465 VAL L 150 REMARK 465 ALA L 151 REMARK 465 TRP L 152 REMARK 465 LYS L 153 REMARK 465 ALA L 154 REMARK 465 ASP L 155 REMARK 465 SER L 156 REMARK 465 SER L 157 REMARK 465 PRO L 158 REMARK 465 VAL L 159 REMARK 465 LYS L 160 REMARK 465 ALA L 161 REMARK 465 GLY L 162 REMARK 465 VAL L 163 REMARK 465 GLU L 164 REMARK 465 THR L 165 REMARK 465 THR L 166 REMARK 465 THR L 167 REMARK 465 PRO L 168 REMARK 465 SER L 169 REMARK 465 LYS L 170 REMARK 465 GLN L 171 REMARK 465 SER L 172 REMARK 465 ASN L 173 REMARK 465 ASN L 174 REMARK 465 LYS L 175 REMARK 465 TYR L 176 REMARK 465 ALA L 177 REMARK 465 ALA L 178 REMARK 465 SER L 179 REMARK 465 SER L 180 REMARK 465 TYR L 181 REMARK 465 LEU L 182 REMARK 465 SER L 183 REMARK 465 LEU L 184 REMARK 465 THR L 185 REMARK 465 PRO L 186 REMARK 465 GLU L 187 REMARK 465 GLN L 188 REMARK 465 TRP L 189 REMARK 465 LYS L 190 REMARK 465 SER L 191 REMARK 465 HIS L 192 REMARK 465 ARG L 193 REMARK 465 SER L 194 REMARK 465 TYR L 195 REMARK 465 SER L 196 REMARK 465 CYS L 197 REMARK 465 GLN L 198 REMARK 465 VAL L 199 REMARK 465 THR L 200 REMARK 465 HIS L 201 REMARK 465 GLU L 202 REMARK 465 GLY L 203 REMARK 465 SER L 204 REMARK 465 THR L 205 REMARK 465 VAL L 206 REMARK 465 GLU L 207 REMARK 465 LYS L 208 REMARK 465 THR L 209 REMARK 465 VAL L 210 REMARK 465 ALA L 211 REMARK 465 PRO L 212 REMARK 465 THR L 213 REMARK 465 GLU L 214 REMARK 465 CYS L 215 REMARK 465 SER L 216 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 LEU A 122 CA - CB - CG ANGL. DEV. = 15.2 DEGREES REMARK 500 CYS A 218 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 ALA A 219 C - N - CA ANGL. DEV. = 17.4 DEGREES REMARK 500 CYS C 418 CA - CB - SG ANGL. DEV. = 13.2 DEGREES REMARK 500 ASP F 624 CB - CG - OD2 ANGL. DEV. = 7.3 DEGREES REMARK 500 ILE H 76 CG1 - CB - CG2 ANGL. DEV. = -14.6 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PHE A 53 -167.47 -79.71 REMARK 500 PRO A 79 45.19 -83.24 REMARK 500 LEU A 122 49.82 -92.00 REMARK 500 SER A 132 -73.22 -82.95 REMARK 500 ASP A 133 129.03 -171.95 REMARK 500 ALA A 134 -161.59 56.40 REMARK 500 GLU A 150 -8.89 73.64 REMARK 500 CYS A 157 66.64 60.56 REMARK 500 THR A 188 49.76 -93.40 REMARK 500 GLU A 190 64.58 -100.00 REMARK 500 CYS A 201 71.44 58.47 REMARK 500 THR A 257 -157.23 -139.92 REMARK 500 GLN A 258 -37.06 -36.84 REMARK 500 LEU A 261 -161.91 -118.25 REMARK 500 ASN A 262 129.44 -37.44 REMARK 500 ASN A 280 52.55 -94.03 REMARK 500 PRO A 299 -168.24 -75.32 REMARK 500 ASN A 300 54.39 -110.27 REMARK 500 ALA A 365 50.18 -91.68 REMARK 500 ARG A 432 172.27 66.50 REMARK 500 THR A 450 -31.45 -130.27 REMARK 500 MET A 475 -6.49 76.68 REMARK 500 ARG A 500 33.92 -96.96 REMARK 500 VAL B 68 -64.67 -128.13 REMARK 500 TRP B 69 -22.67 -145.58 REMARK 500 PRO B 79 48.45 -87.55 REMARK 500 SER B 80 79.00 -155.50 REMARK 500 LYS B 97 57.63 -94.54 REMARK 500 PRO B 118 57.92 -90.46 REMARK 500 LEU B 122 49.49 -94.74 REMARK 500 GLU B 150 6.78 56.80 REMARK 500 CYS B 157 66.54 60.84 REMARK 500 SER B 185 41.06 -109.87 REMARK 500 SER B 189 34.96 -98.77 REMARK 500 SER B 199 33.02 -140.70 REMARK 500 ALA B 200 -148.31 59.33 REMARK 500 PRO B 206 37.71 -86.70 REMARK 500 LEU B 259 69.99 61.32 REMARK 500 LEU B 261 -159.00 -88.61 REMARK 500 ASN B 262 130.15 -38.79 REMARK 500 ARG B 432 -141.31 49.99 REMARK 500 PRO C 79 46.78 -84.91 REMARK 500 LEU C 122 49.61 -91.77 REMARK 500 LEU C 125 50.85 -92.21 REMARK 500 SER C 132 -168.24 -126.21 REMARK 500 CYS C 157 67.53 60.12 REMARK 500 ASN C 186 52.32 -91.24 REMARK 500 THR C 198 -63.14 -101.47 REMARK 500 ALA C 200 -103.61 68.44 REMARK 500 PRO C 206 43.96 -86.38 REMARK 500 REMARK 500 THIS ENTRY HAS 71 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-43881 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF CH848.D949.10.17.GS-DH270.UCA4 DBREF 9AUI A 31 498 UNP Q2N0S6 Q2N0S6_9HIV1 30 495 DBREF 9AUI B 31 498 UNP Q2N0S6 Q2N0S6_9HIV1 30 495 DBREF 9AUI C 31 498 UNP Q2N0S6 Q2N0S6_9HIV1 30 495 DBREF 9AUI D 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 9AUI E 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 9AUI F 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 9AUI G 1 232 PDB 9AUI 9AUI 1 232 DBREF 9AUI H 1 232 PDB 9AUI 9AUI 1 232 DBREF 9AUI I 1 232 PDB 9AUI 9AUI 1 232 DBREF 9AUI J 1 216 PDB 9AUI 9AUI 1 216 DBREF 9AUI K 1 216 PDB 9AUI 9AUI 1 216 DBREF 9AUI L 1 216 PDB 9AUI 9AUI 1 216 SEQADV 9AUI GLU A 47 UNP Q2N0S6 ASP 46 CONFLICT SEQADV 9AUI LYS A 49 UNP Q2N0S6 GLU 48 CONFLICT SEQADV 9AUI ARG A 59 UNP Q2N0S6 LYS 58 CONFLICT SEQADV 9AUI LYS A 63 UNP Q2N0S6 THR 62 CONFLICT SEQADV 9AUI VAL A 65 UNP Q2N0S6 LYS 64 CONFLICT SEQADV 9AUI SER A 80 UNP Q2N0S6 ASN 79 CONFLICT SEQADV 9AUI LEU A 84 UNP Q2N0S6 ILE 83 CONFLICT SEQADV 9AUI VAL A 85 UNP Q2N0S6 HIS 84 CONFLICT SEQADV 9AUI GLY A 87 UNP Q2N0S6 GLU 86 CONFLICT SEQADV 9AUI ASN A 92 UNP Q2N0S6 GLU 91 CONFLICT SEQADV 9AUI ASP A 99 UNP Q2N0S6 ASN 98 CONFLICT SEQADV 9AUI ASP A 102 UNP Q2N0S6 GLU 101 CONFLICT SEQADV 9AUI GLU A 106 UNP Q2N0S6 THR 105 CONFLICT SEQADV 9AUI ILE A 130 UNP Q2N0S6 GLN 129 CONFLICT SEQADV 9AUI A UNP Q2N0S6 THR 131 DELETION SEQADV 9AUI A UNP Q2N0S6 ASN 132 DELETION SEQADV 9AUI A UNP Q2N0S6 VAL 133 DELETION SEQADV 9AUI A UNP Q2N0S6 THR 134 DELETION SEQADV 9AUI A UNP Q2N0S6 ASN 135 DELETION SEQADV 9AUI A UNP Q2N0S6 ASN 136 DELETION SEQADV 9AUI A UNP Q2N0S6 ILE 137 DELETION SEQADV 9AUI SER A 132 UNP Q2N0S6 THR 138 CONFLICT SEQADV 9AUI ALA A 134 UNP Q2N0S6 ASP 140 CONFLICT SEQADV 9AUI GLY A 135 UNP Q2N0S6 MET 141 CONFLICT SEQADV 9AUI SER A 136 UNP Q2N0S6 ARG 142 CONFLICT SEQADV 9AUI GLY A 138 UNP Q2N0S6 INSERTION SEQADV 9AUI VAL A 149 UNP Q2N0S6 INSERTION SEQADV 9AUI GLU A 150 UNP Q2N0S6 INSERTION SEQADV 9AUI MET A 154 UNP Q2N0S6 LEU 145 CONFLICT SEQADV 9AUI THR A 161 UNP Q2N0S6 MET 152 CONFLICT SEQADV 9AUI ILE A 165 UNP Q2N0S6 LEU 156 CONFLICT SEQADV 9AUI GLU A 169 UNP Q2N0S6 LYS 160 CONFLICT SEQADV 9AUI LYS A 170 UNP Q2N0S6 GLN 161 CONFLICT SEQADV 9AUI GLU A 172 UNP Q2N0S6 VAL 163 CONFLICT SEQADV 9AUI ALA A 174 UNP Q2N0S6 SER 165 CONFLICT SEQADV 9AUI LYS A 178 UNP Q2N0S6 ARG 169 CONFLICT SEQADV 9AUI PRO A 179 UNP Q2N0S6 LEU 170 CONFLICT SEQADV 9AUI ILE A 181 UNP Q2N0S6 VAL 172 CONFLICT SEQADV 9AUI PRO A 183 UNP Q2N0S6 GLN 174 CONFLICT SEQADV 9AUI LEU A 184 UNP Q2N0S6 ILE 175 CONFLICT SEQADV 9AUI SER A 185 UNP Q2N0S6 ASN 176 CONFLICT SEQADV 9AUI A UNP Q2N0S6 ASN 178 DELETION SEQADV 9AUI A UNP Q2N0S6 GLN 179 DELETION SEQADV 9AUI A UNP Q2N0S6 GLY 180 DELETION SEQADV 9AUI A UNP Q2N0S6 ASN 181 DELETION SEQADV 9AUI A UNP Q2N0S6 ARG 182 DELETION SEQADV 9AUI A UNP Q2N0S6 SER 183 DELETION SEQADV 9AUI THR A 185B UNP Q2N0S6 ASN 184 CONFLICT SEQADV 9AUI ASN A 187 UNP Q2N0S6 SER 186 CONFLICT SEQADV 9AUI THR A 188 UNP Q2N0S6 ASN 187 CONFLICT SEQADV 9AUI SER A 189 UNP Q2N0S6 LYS 188 CONFLICT SEQADV 9AUI CYS A 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 9AUI THR A 209 UNP Q2N0S6 SER 208 CONFLICT SEQADV 9AUI TYR A 223 UNP Q2N0S6 PHE 222 CONFLICT SEQADV 9AUI ASN A 229 UNP Q2N0S6 LYS 228 CONFLICT SEQADV 9AUI GLU A 231 UNP Q2N0S6 LYS 230 CONFLICT SEQADV 9AUI THR A 232 UNP Q2N0S6 LYS 231 CONFLICT SEQADV 9AUI SER A 240 UNP Q2N0S6 PRO 239 CONFLICT SEQADV 9AUI ASN A 241 UNP Q2N0S6 SER 240 CONFLICT SEQADV 9AUI ARG A 252 UNP Q2N0S6 LYS 251 CONFLICT SEQADV 9AUI LYS A 268 UNP Q2N0S6 GLU 267 CONFLICT SEQADV 9AUI ILE A 270 UNP Q2N0S6 VAL 269 CONFLICT SEQADV 9AUI VAL A 271 UNP Q2N0S6 MET 270 CONFLICT SEQADV 9AUI LEU A 277 UNP Q2N0S6 ILE 276 CONFLICT SEQADV 9AUI ILE A 283 UNP Q2N0S6 ASN 282 CONFLICT SEQADV 9AUI ILE A 285 UNP Q2N0S6 LEU 284 CONFLICT SEQADV 9AUI HIS A 287 UNP Q2N0S6 GLN 286 CONFLICT SEQADV 9AUI LEU A 288 UNP Q2N0S6 PHE 287 CONFLICT SEQADV 9AUI HIS A 289 UNP Q2N0S6 ASN 288 CONFLICT SEQADV 9AUI GLU A 293 UNP Q2N0S6 GLN 292 CONFLICT SEQADV 9AUI VAL A 295 UNP Q2N0S6 ASN 294 CONFLICT SEQADV 9AUI VAL A 307 UNP Q2N0S6 ILE 306 CONFLICT SEQADV 9AUI THR A 316 UNP Q2N0S6 ALA 313 CONFLICT SEQADV 9AUI LYS A 327 UNP Q2N0S6 ARG 325 CONFLICT SEQADV 9AUI ASN A 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 9AUI ILE A 333 UNP Q2N0S6 VAL 331 CONFLICT SEQADV 9AUI GLU A 335 UNP Q2N0S6 LYS 333 CONFLICT SEQADV 9AUI GLU A 336 UNP Q2N0S6 ALA 334 CONFLICT SEQADV 9AUI LYS A 337 UNP Q2N0S6 THR 335 CONFLICT SEQADV 9AUI ASP A 340 UNP Q2N0S6 GLU 338 CONFLICT SEQADV 9AUI GLN A 343 UNP Q2N0S6 GLY 341 CONFLICT SEQADV 9AUI GLY A 346 UNP Q2N0S6 VAL 344 CONFLICT SEQADV 9AUI ILE A 347 UNP Q2N0S6 LYS 345 CONFLICT SEQADV 9AUI GLU A 348 UNP Q2N0S6 GLN 346 CONFLICT SEQADV 9AUI GLN A 350 UNP Q2N0S6 ARG 348 CONFLICT SEQADV 9AUI PRO A 354 UNP Q2N0S6 GLY 352 CONFLICT SEQADV 9AUI LYS A 356 UNP Q2N0S6 ASN 354 CONFLICT SEQADV 9AUI A UNP Q2N0S6 ILE 357 DELETION SEQADV 9AUI A UNP Q2N0S6 ARG 358 DELETION SEQADV 9AUI LYS A 360 UNP Q2N0S6 PHE 359 CONFLICT SEQADV 9AUI TYR A 361 UNP Q2N0S6 ALA 360 CONFLICT SEQADV 9AUI GLN A 363 UNP Q2N0S6 INSERTION SEQADV 9AUI ALA A 365 UNP Q2N0S6 SER 363 CONFLICT SEQADV 9AUI MET A 369 UNP Q2N0S6 LEU 367 CONFLICT SEQADV 9AUI ILE A 371 UNP Q2N0S6 VAL 369 CONFLICT SEQADV 9AUI ASN A 389 UNP Q2N0S6 GLY 387 CONFLICT SEQADV 9AUI ASN A 392 UNP Q2N0S6 INSERTION SEQADV 9AUI GLY A 393 UNP Q2N0S6 INSERTION SEQADV 9AUI THR A 394 UNP Q2N0S6 INSERTION SEQADV 9AUI TYR A 395 UNP Q2N0S6 INSERTION SEQADV 9AUI GLY A 397 UNP Q2N0S6 SER 391 CONFLICT SEQADV 9AUI TYR A 400 UNP Q2N0S6 TRP 393 CONFLICT SEQADV 9AUI THR A 403 UNP Q2N0S6 ASN 396 CONFLICT SEQADV 9AUI ASN A 404 UNP Q2N0S6 THR 397 CONFLICT SEQADV 9AUI SER A 406 UNP Q2N0S6 VAL 399 CONFLICT SEQADV 9AUI ALA A 407 UNP Q2N0S6 GLN 400 CONFLICT SEQADV 9AUI ASN A 408 UNP Q2N0S6 GLY 401 CONFLICT SEQADV 9AUI THR A 411 UNP Q2N0S6 ASN 403 CONFLICT SEQADV 9AUI A UNP Q2N0S6 GLY 406 DELETION SEQADV 9AUI A UNP Q2N0S6 SER 407 DELETION SEQADV 9AUI A UNP Q2N0S6 ASN 408 DELETION SEQADV 9AUI A UNP Q2N0S6 ASP 409 DELETION SEQADV 9AUI A UNP Q2N0S6 SER 410 DELETION SEQADV 9AUI GLN A 417 UNP Q2N0S6 PRO 414 CONFLICT SEQADV 9AUI GLY A 429 UNP Q2N0S6 ARG 426 CONFLICT SEQADV 9AUI VAL A 430 UNP Q2N0S6 ILE 427 CONFLICT SEQADV 9AUI ARG A 432 UNP Q2N0S6 GLN 429 CONFLICT SEQADV 9AUI CYS A 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 9AUI ALA A 440 UNP Q2N0S6 GLN 437 CONFLICT SEQADV 9AUI ASN A 442 UNP Q2N0S6 VAL 439 CONFLICT SEQADV 9AUI THR A 444 UNP Q2N0S6 ARG 441 CONFLICT SEQADV 9AUI ARG A 446 UNP Q2N0S6 VAL 443 CONFLICT SEQADV 9AUI LEU A 453 UNP Q2N0S6 ILE 450 CONFLICT SEQADV 9AUI THR A 460 UNP Q2N0S6 SER 457 CONFLICT SEQADV 9AUI ASN A 461 UNP Q2N0S6 THR 458 CONFLICT SEQADV 9AUI SER A 462 UNP Q2N0S6 ASN 459 CONFLICT SEQADV 9AUI ASN A 463 UNP Q2N0S6 SER 460 CONFLICT SEQADV 9AUI GLU A 464 UNP Q2N0S6 THR 461 CONFLICT SEQADV 9AUI ALA A 471 UNP Q2N0S6 GLY 468 CONFLICT SEQADV 9AUI THR A 499 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 500 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI CYS A 501 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI LYS A 502 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 503 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 504 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI VAL A 505 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI VAL A 506 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI GLY A 507 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 508 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 509 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 510 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 511 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG A 513 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI GLU B 47 UNP Q2N0S6 ASP 46 CONFLICT SEQADV 9AUI LYS B 49 UNP Q2N0S6 GLU 48 CONFLICT SEQADV 9AUI ARG B 59 UNP Q2N0S6 LYS 58 CONFLICT SEQADV 9AUI LYS B 63 UNP Q2N0S6 THR 62 CONFLICT SEQADV 9AUI VAL B 65 UNP Q2N0S6 LYS 64 CONFLICT SEQADV 9AUI SER B 80 UNP Q2N0S6 ASN 79 CONFLICT SEQADV 9AUI LEU B 84 UNP Q2N0S6 ILE 83 CONFLICT SEQADV 9AUI VAL B 85 UNP Q2N0S6 HIS 84 CONFLICT SEQADV 9AUI GLY B 87 UNP Q2N0S6 GLU 86 CONFLICT SEQADV 9AUI ASN B 92 UNP Q2N0S6 GLU 91 CONFLICT SEQADV 9AUI ASP B 99 UNP Q2N0S6 ASN 98 CONFLICT SEQADV 9AUI ASP B 102 UNP Q2N0S6 GLU 101 CONFLICT SEQADV 9AUI GLU B 106 UNP Q2N0S6 THR 105 CONFLICT SEQADV 9AUI ILE B 130 UNP Q2N0S6 GLN 129 CONFLICT SEQADV 9AUI B UNP Q2N0S6 THR 131 DELETION SEQADV 9AUI B UNP Q2N0S6 ASN 132 DELETION SEQADV 9AUI B UNP Q2N0S6 VAL 133 DELETION SEQADV 9AUI B UNP Q2N0S6 THR 134 DELETION SEQADV 9AUI B UNP Q2N0S6 ASN 135 DELETION SEQADV 9AUI B UNP Q2N0S6 ASN 136 DELETION SEQADV 9AUI B UNP Q2N0S6 ILE 137 DELETION SEQADV 9AUI SER B 132 UNP Q2N0S6 THR 138 CONFLICT SEQADV 9AUI ALA B 134 UNP Q2N0S6 ASP 140 CONFLICT SEQADV 9AUI GLY B 135 UNP Q2N0S6 MET 141 CONFLICT SEQADV 9AUI SER B 136 UNP Q2N0S6 ARG 142 CONFLICT SEQADV 9AUI GLY B 138 UNP Q2N0S6 INSERTION SEQADV 9AUI VAL B 149 UNP Q2N0S6 INSERTION SEQADV 9AUI GLU B 150 UNP Q2N0S6 INSERTION SEQADV 9AUI MET B 154 UNP Q2N0S6 LEU 145 CONFLICT SEQADV 9AUI THR B 161 UNP Q2N0S6 MET 152 CONFLICT SEQADV 9AUI ILE B 165 UNP Q2N0S6 LEU 156 CONFLICT SEQADV 9AUI GLU B 169 UNP Q2N0S6 LYS 160 CONFLICT SEQADV 9AUI LYS B 170 UNP Q2N0S6 GLN 161 CONFLICT SEQADV 9AUI GLU B 172 UNP Q2N0S6 VAL 163 CONFLICT SEQADV 9AUI ALA B 174 UNP Q2N0S6 SER 165 CONFLICT SEQADV 9AUI LYS B 178 UNP Q2N0S6 ARG 169 CONFLICT SEQADV 9AUI PRO B 179 UNP Q2N0S6 LEU 170 CONFLICT SEQADV 9AUI ILE B 181 UNP Q2N0S6 VAL 172 CONFLICT SEQADV 9AUI PRO B 183 UNP Q2N0S6 GLN 174 CONFLICT SEQADV 9AUI LEU B 184 UNP Q2N0S6 ILE 175 CONFLICT SEQADV 9AUI SER B 185 UNP Q2N0S6 ASN 176 CONFLICT SEQADV 9AUI B UNP Q2N0S6 ASN 178 DELETION SEQADV 9AUI B UNP Q2N0S6 GLN 179 DELETION SEQADV 9AUI B UNP Q2N0S6 GLY 180 DELETION SEQADV 9AUI B UNP Q2N0S6 ASN 181 DELETION SEQADV 9AUI B UNP Q2N0S6 ARG 182 DELETION SEQADV 9AUI B UNP Q2N0S6 SER 183 DELETION SEQADV 9AUI THR B 185B UNP Q2N0S6 ASN 184 CONFLICT SEQADV 9AUI ASN B 187 UNP Q2N0S6 SER 186 CONFLICT SEQADV 9AUI THR B 188 UNP Q2N0S6 ASN 187 CONFLICT SEQADV 9AUI SER B 189 UNP Q2N0S6 LYS 188 CONFLICT SEQADV 9AUI CYS B 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 9AUI THR B 209 UNP Q2N0S6 SER 208 CONFLICT SEQADV 9AUI TYR B 223 UNP Q2N0S6 PHE 222 CONFLICT SEQADV 9AUI ASN B 229 UNP Q2N0S6 LYS 228 CONFLICT SEQADV 9AUI GLU B 231 UNP Q2N0S6 LYS 230 CONFLICT SEQADV 9AUI THR B 232 UNP Q2N0S6 LYS 231 CONFLICT SEQADV 9AUI SER B 240 UNP Q2N0S6 PRO 239 CONFLICT SEQADV 9AUI ASN B 241 UNP Q2N0S6 SER 240 CONFLICT SEQADV 9AUI ARG B 252 UNP Q2N0S6 LYS 251 CONFLICT SEQADV 9AUI LYS B 268 UNP Q2N0S6 GLU 267 CONFLICT SEQADV 9AUI ILE B 270 UNP Q2N0S6 VAL 269 CONFLICT SEQADV 9AUI VAL B 271 UNP Q2N0S6 MET 270 CONFLICT SEQADV 9AUI LEU B 277 UNP Q2N0S6 ILE 276 CONFLICT SEQADV 9AUI ILE B 283 UNP Q2N0S6 ASN 282 CONFLICT SEQADV 9AUI ILE B 285 UNP Q2N0S6 LEU 284 CONFLICT SEQADV 9AUI HIS B 287 UNP Q2N0S6 GLN 286 CONFLICT SEQADV 9AUI LEU B 288 UNP Q2N0S6 PHE 287 CONFLICT SEQADV 9AUI HIS B 289 UNP Q2N0S6 ASN 288 CONFLICT SEQADV 9AUI GLU B 293 UNP Q2N0S6 GLN 292 CONFLICT SEQADV 9AUI VAL B 295 UNP Q2N0S6 ASN 294 CONFLICT SEQADV 9AUI VAL B 307 UNP Q2N0S6 ILE 306 CONFLICT SEQADV 9AUI THR B 316 UNP Q2N0S6 ALA 313 CONFLICT SEQADV 9AUI LYS B 327 UNP Q2N0S6 ARG 325 CONFLICT SEQADV 9AUI ASN B 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 9AUI ILE B 333 UNP Q2N0S6 VAL 331 CONFLICT SEQADV 9AUI GLU B 335 UNP Q2N0S6 LYS 333 CONFLICT SEQADV 9AUI GLU B 336 UNP Q2N0S6 ALA 334 CONFLICT SEQADV 9AUI LYS B 337 UNP Q2N0S6 THR 335 CONFLICT SEQADV 9AUI ASP B 340 UNP Q2N0S6 GLU 338 CONFLICT SEQADV 9AUI GLN B 343 UNP Q2N0S6 GLY 341 CONFLICT SEQADV 9AUI GLY B 346 UNP Q2N0S6 VAL 344 CONFLICT SEQADV 9AUI ILE B 347 UNP Q2N0S6 LYS 345 CONFLICT SEQADV 9AUI GLU B 348 UNP Q2N0S6 GLN 346 CONFLICT SEQADV 9AUI GLN B 350 UNP Q2N0S6 ARG 348 CONFLICT SEQADV 9AUI PRO B 354 UNP Q2N0S6 GLY 352 CONFLICT SEQADV 9AUI LYS B 356 UNP Q2N0S6 ASN 354 CONFLICT SEQADV 9AUI B UNP Q2N0S6 ILE 357 DELETION SEQADV 9AUI B UNP Q2N0S6 ARG 358 DELETION SEQADV 9AUI LYS B 360 UNP Q2N0S6 PHE 359 CONFLICT SEQADV 9AUI TYR B 361 UNP Q2N0S6 ALA 360 CONFLICT SEQADV 9AUI GLN B 363 UNP Q2N0S6 INSERTION SEQADV 9AUI ALA B 365 UNP Q2N0S6 SER 363 CONFLICT SEQADV 9AUI MET B 369 UNP Q2N0S6 LEU 367 CONFLICT SEQADV 9AUI ILE B 371 UNP Q2N0S6 VAL 369 CONFLICT SEQADV 9AUI ASN B 389 UNP Q2N0S6 GLY 387 CONFLICT SEQADV 9AUI ASN B 392 UNP Q2N0S6 INSERTION SEQADV 9AUI GLY B 393 UNP Q2N0S6 INSERTION SEQADV 9AUI THR B 394 UNP Q2N0S6 INSERTION SEQADV 9AUI TYR B 395 UNP Q2N0S6 INSERTION SEQADV 9AUI GLY B 397 UNP Q2N0S6 SER 391 CONFLICT SEQADV 9AUI TYR B 400 UNP Q2N0S6 TRP 393 CONFLICT SEQADV 9AUI THR B 403 UNP Q2N0S6 ASN 396 CONFLICT SEQADV 9AUI ASN B 404 UNP Q2N0S6 THR 397 CONFLICT SEQADV 9AUI SER B 406 UNP Q2N0S6 VAL 399 CONFLICT SEQADV 9AUI ALA B 407 UNP Q2N0S6 GLN 400 CONFLICT SEQADV 9AUI ASN B 408 UNP Q2N0S6 GLY 401 CONFLICT SEQADV 9AUI THR B 411 UNP Q2N0S6 ASN 403 CONFLICT SEQADV 9AUI B UNP Q2N0S6 GLY 406 DELETION SEQADV 9AUI B UNP Q2N0S6 SER 407 DELETION SEQADV 9AUI B UNP Q2N0S6 ASN 408 DELETION SEQADV 9AUI B UNP Q2N0S6 ASP 409 DELETION SEQADV 9AUI B UNP Q2N0S6 SER 410 DELETION SEQADV 9AUI GLN B 417 UNP Q2N0S6 PRO 414 CONFLICT SEQADV 9AUI GLY B 429 UNP Q2N0S6 ARG 426 CONFLICT SEQADV 9AUI VAL B 430 UNP Q2N0S6 ILE 427 CONFLICT SEQADV 9AUI ARG B 432 UNP Q2N0S6 GLN 429 CONFLICT SEQADV 9AUI CYS B 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 9AUI ALA B 440 UNP Q2N0S6 GLN 437 CONFLICT SEQADV 9AUI ASN B 442 UNP Q2N0S6 VAL 439 CONFLICT SEQADV 9AUI THR B 444 UNP Q2N0S6 ARG 441 CONFLICT SEQADV 9AUI ARG B 446 UNP Q2N0S6 VAL 443 CONFLICT SEQADV 9AUI LEU B 453 UNP Q2N0S6 ILE 450 CONFLICT SEQADV 9AUI THR B 460 UNP Q2N0S6 SER 457 CONFLICT SEQADV 9AUI ASN B 461 UNP Q2N0S6 THR 458 CONFLICT SEQADV 9AUI SER B 462 UNP Q2N0S6 ASN 459 CONFLICT SEQADV 9AUI ASN B 463 UNP Q2N0S6 SER 460 CONFLICT SEQADV 9AUI GLU B 464 UNP Q2N0S6 THR 461 CONFLICT SEQADV 9AUI ALA B 471 UNP Q2N0S6 GLY 468 CONFLICT SEQADV 9AUI THR B 499 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 500 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI CYS B 501 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI LYS B 502 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 503 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 504 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI VAL B 505 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI VAL B 506 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI GLY B 507 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 508 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 509 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 510 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 511 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG B 513 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI GLU C 47 UNP Q2N0S6 ASP 46 CONFLICT SEQADV 9AUI LYS C 49 UNP Q2N0S6 GLU 48 CONFLICT SEQADV 9AUI ARG C 59 UNP Q2N0S6 LYS 58 CONFLICT SEQADV 9AUI LYS C 63 UNP Q2N0S6 THR 62 CONFLICT SEQADV 9AUI VAL C 65 UNP Q2N0S6 LYS 64 CONFLICT SEQADV 9AUI SER C 80 UNP Q2N0S6 ASN 79 CONFLICT SEQADV 9AUI LEU C 84 UNP Q2N0S6 ILE 83 CONFLICT SEQADV 9AUI VAL C 85 UNP Q2N0S6 HIS 84 CONFLICT SEQADV 9AUI GLY C 87 UNP Q2N0S6 GLU 86 CONFLICT SEQADV 9AUI ASN C 92 UNP Q2N0S6 GLU 91 CONFLICT SEQADV 9AUI ASP C 99 UNP Q2N0S6 ASN 98 CONFLICT SEQADV 9AUI ASP C 102 UNP Q2N0S6 GLU 101 CONFLICT SEQADV 9AUI GLU C 106 UNP Q2N0S6 THR 105 CONFLICT SEQADV 9AUI ILE C 130 UNP Q2N0S6 GLN 129 CONFLICT SEQADV 9AUI C UNP Q2N0S6 THR 131 DELETION SEQADV 9AUI C UNP Q2N0S6 ASN 132 DELETION SEQADV 9AUI C UNP Q2N0S6 VAL 133 DELETION SEQADV 9AUI C UNP Q2N0S6 THR 134 DELETION SEQADV 9AUI C UNP Q2N0S6 ASN 135 DELETION SEQADV 9AUI C UNP Q2N0S6 ASN 136 DELETION SEQADV 9AUI C UNP Q2N0S6 ILE 137 DELETION SEQADV 9AUI SER C 132 UNP Q2N0S6 THR 138 CONFLICT SEQADV 9AUI ALA C 134 UNP Q2N0S6 ASP 140 CONFLICT SEQADV 9AUI GLY C 135 UNP Q2N0S6 MET 141 CONFLICT SEQADV 9AUI SER C 136 UNP Q2N0S6 ARG 142 CONFLICT SEQADV 9AUI GLY C 138 UNP Q2N0S6 INSERTION SEQADV 9AUI VAL C 149 UNP Q2N0S6 INSERTION SEQADV 9AUI GLU C 150 UNP Q2N0S6 INSERTION SEQADV 9AUI MET C 154 UNP Q2N0S6 LEU 145 CONFLICT SEQADV 9AUI THR C 161 UNP Q2N0S6 MET 152 CONFLICT SEQADV 9AUI ILE C 165 UNP Q2N0S6 LEU 156 CONFLICT SEQADV 9AUI GLU C 169 UNP Q2N0S6 LYS 160 CONFLICT SEQADV 9AUI LYS C 170 UNP Q2N0S6 GLN 161 CONFLICT SEQADV 9AUI GLU C 172 UNP Q2N0S6 VAL 163 CONFLICT SEQADV 9AUI ALA C 174 UNP Q2N0S6 SER 165 CONFLICT SEQADV 9AUI LYS C 178 UNP Q2N0S6 ARG 169 CONFLICT SEQADV 9AUI PRO C 179 UNP Q2N0S6 LEU 170 CONFLICT SEQADV 9AUI ILE C 181 UNP Q2N0S6 VAL 172 CONFLICT SEQADV 9AUI PRO C 183 UNP Q2N0S6 GLN 174 CONFLICT SEQADV 9AUI LEU C 184 UNP Q2N0S6 ILE 175 CONFLICT SEQADV 9AUI SER C 185 UNP Q2N0S6 ASN 176 CONFLICT SEQADV 9AUI C UNP Q2N0S6 ASN 178 DELETION SEQADV 9AUI C UNP Q2N0S6 GLN 179 DELETION SEQADV 9AUI C UNP Q2N0S6 GLY 180 DELETION SEQADV 9AUI C UNP Q2N0S6 ASN 181 DELETION SEQADV 9AUI C UNP Q2N0S6 ARG 182 DELETION SEQADV 9AUI C UNP Q2N0S6 SER 183 DELETION SEQADV 9AUI THR C 185B UNP Q2N0S6 ASN 184 CONFLICT SEQADV 9AUI ASN C 187 UNP Q2N0S6 SER 186 CONFLICT SEQADV 9AUI THR C 188 UNP Q2N0S6 ASN 187 CONFLICT SEQADV 9AUI SER C 189 UNP Q2N0S6 LYS 188 CONFLICT SEQADV 9AUI CYS C 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 9AUI THR C 209 UNP Q2N0S6 SER 208 CONFLICT SEQADV 9AUI TYR C 223 UNP Q2N0S6 PHE 222 CONFLICT SEQADV 9AUI ASN C 229 UNP Q2N0S6 LYS 228 CONFLICT SEQADV 9AUI GLU C 231 UNP Q2N0S6 LYS 230 CONFLICT SEQADV 9AUI THR C 232 UNP Q2N0S6 LYS 231 CONFLICT SEQADV 9AUI SER C 240 UNP Q2N0S6 PRO 239 CONFLICT SEQADV 9AUI ASN C 241 UNP Q2N0S6 SER 240 CONFLICT SEQADV 9AUI ARG C 252 UNP Q2N0S6 LYS 251 CONFLICT SEQADV 9AUI LYS C 268 UNP Q2N0S6 GLU 267 CONFLICT SEQADV 9AUI ILE C 270 UNP Q2N0S6 VAL 269 CONFLICT SEQADV 9AUI VAL C 271 UNP Q2N0S6 MET 270 CONFLICT SEQADV 9AUI LEU C 277 UNP Q2N0S6 ILE 276 CONFLICT SEQADV 9AUI ILE C 283 UNP Q2N0S6 ASN 282 CONFLICT SEQADV 9AUI ILE C 285 UNP Q2N0S6 LEU 284 CONFLICT SEQADV 9AUI HIS C 287 UNP Q2N0S6 GLN 286 CONFLICT SEQADV 9AUI LEU C 288 UNP Q2N0S6 PHE 287 CONFLICT SEQADV 9AUI HIS C 289 UNP Q2N0S6 ASN 288 CONFLICT SEQADV 9AUI GLU C 293 UNP Q2N0S6 GLN 292 CONFLICT SEQADV 9AUI VAL C 295 UNP Q2N0S6 ASN 294 CONFLICT SEQADV 9AUI VAL C 307 UNP Q2N0S6 ILE 306 CONFLICT SEQADV 9AUI THR C 316 UNP Q2N0S6 ALA 313 CONFLICT SEQADV 9AUI LYS C 327 UNP Q2N0S6 ARG 325 CONFLICT SEQADV 9AUI ASN C 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 9AUI ILE C 333 UNP Q2N0S6 VAL 331 CONFLICT SEQADV 9AUI GLU C 335 UNP Q2N0S6 LYS 333 CONFLICT SEQADV 9AUI GLU C 336 UNP Q2N0S6 ALA 334 CONFLICT SEQADV 9AUI LYS C 337 UNP Q2N0S6 THR 335 CONFLICT SEQADV 9AUI ASP C 340 UNP Q2N0S6 GLU 338 CONFLICT SEQADV 9AUI GLN C 343 UNP Q2N0S6 GLY 341 CONFLICT SEQADV 9AUI GLY C 346 UNP Q2N0S6 VAL 344 CONFLICT SEQADV 9AUI ILE C 347 UNP Q2N0S6 LYS 345 CONFLICT SEQADV 9AUI GLU C 348 UNP Q2N0S6 GLN 346 CONFLICT SEQADV 9AUI GLN C 350 UNP Q2N0S6 ARG 348 CONFLICT SEQADV 9AUI PRO C 354 UNP Q2N0S6 GLY 352 CONFLICT SEQADV 9AUI LYS C 356 UNP Q2N0S6 ASN 354 CONFLICT SEQADV 9AUI C UNP Q2N0S6 ILE 357 DELETION SEQADV 9AUI C UNP Q2N0S6 ARG 358 DELETION SEQADV 9AUI LYS C 360 UNP Q2N0S6 PHE 359 CONFLICT SEQADV 9AUI TYR C 361 UNP Q2N0S6 ALA 360 CONFLICT SEQADV 9AUI GLN C 363 UNP Q2N0S6 INSERTION SEQADV 9AUI ALA C 365 UNP Q2N0S6 SER 363 CONFLICT SEQADV 9AUI MET C 369 UNP Q2N0S6 LEU 367 CONFLICT SEQADV 9AUI ILE C 371 UNP Q2N0S6 VAL 369 CONFLICT SEQADV 9AUI ASN C 389 UNP Q2N0S6 GLY 387 CONFLICT SEQADV 9AUI ASN C 392 UNP Q2N0S6 INSERTION SEQADV 9AUI GLY C 393 UNP Q2N0S6 INSERTION SEQADV 9AUI THR C 394 UNP Q2N0S6 INSERTION SEQADV 9AUI TYR C 395 UNP Q2N0S6 INSERTION SEQADV 9AUI GLY C 397 UNP Q2N0S6 SER 391 CONFLICT SEQADV 9AUI TYR C 400 UNP Q2N0S6 TRP 393 CONFLICT SEQADV 9AUI THR C 403 UNP Q2N0S6 ASN 396 CONFLICT SEQADV 9AUI ASN C 404 UNP Q2N0S6 THR 397 CONFLICT SEQADV 9AUI SER C 406 UNP Q2N0S6 VAL 399 CONFLICT SEQADV 9AUI ALA C 407 UNP Q2N0S6 GLN 400 CONFLICT SEQADV 9AUI ASN C 408 UNP Q2N0S6 GLY 401 CONFLICT SEQADV 9AUI THR C 411 UNP Q2N0S6 ASN 403 CONFLICT SEQADV 9AUI C UNP Q2N0S6 GLY 406 DELETION SEQADV 9AUI C UNP Q2N0S6 SER 407 DELETION SEQADV 9AUI C UNP Q2N0S6 ASN 408 DELETION SEQADV 9AUI C UNP Q2N0S6 ASP 409 DELETION SEQADV 9AUI C UNP Q2N0S6 SER 410 DELETION SEQADV 9AUI GLN C 417 UNP Q2N0S6 PRO 414 CONFLICT SEQADV 9AUI GLY C 429 UNP Q2N0S6 ARG 426 CONFLICT SEQADV 9AUI VAL C 430 UNP Q2N0S6 ILE 427 CONFLICT SEQADV 9AUI ARG C 432 UNP Q2N0S6 GLN 429 CONFLICT SEQADV 9AUI CYS C 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 9AUI ALA C 440 UNP Q2N0S6 GLN 437 CONFLICT SEQADV 9AUI ASN C 442 UNP Q2N0S6 VAL 439 CONFLICT SEQADV 9AUI THR C 444 UNP Q2N0S6 ARG 441 CONFLICT SEQADV 9AUI ARG C 446 UNP Q2N0S6 VAL 443 CONFLICT SEQADV 9AUI LEU C 453 UNP Q2N0S6 ILE 450 CONFLICT SEQADV 9AUI THR C 460 UNP Q2N0S6 SER 457 CONFLICT SEQADV 9AUI ASN C 461 UNP Q2N0S6 THR 458 CONFLICT SEQADV 9AUI SER C 462 UNP Q2N0S6 ASN 459 CONFLICT SEQADV 9AUI ASN C 463 UNP Q2N0S6 SER 460 CONFLICT SEQADV 9AUI GLU C 464 UNP Q2N0S6 THR 461 CONFLICT SEQADV 9AUI ALA C 471 UNP Q2N0S6 GLY 468 CONFLICT SEQADV 9AUI THR C 499 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 500 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI CYS C 501 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI LYS C 502 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 503 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 504 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI VAL C 505 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI VAL C 506 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI GLY C 507 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 508 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 509 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 510 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 511 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI ARG C 513 UNP Q2N0S6 EXPRESSION TAG SEQADV 9AUI PRO D 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 9AUI CYS D 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQADV 9AUI PRO E 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 9AUI CYS E 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQADV 9AUI PRO F 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 9AUI CYS F 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQRES 1 A 469 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 A 469 VAL TRP LYS GLU ALA LYS THR THR LEU PHE CYS ALA SER SEQRES 3 A 469 ASP ALA ARG ALA TYR GLU LYS GLU VAL HIS ASN VAL TRP SEQRES 4 A 469 ALA THR HIS ALA CYS VAL PRO THR ASP PRO SER PRO GLN SEQRES 5 A 469 GLU LEU VAL LEU GLY ASN VAL THR GLU ASN PHE ASN MET SEQRES 6 A 469 TRP LYS ASN ASP MET VAL ASP GLN MET HIS GLU ASP ILE SEQRES 7 A 469 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 A 469 LEU THR PRO LEU CYS VAL THR LEU ILE CYS SER ASP ALA SEQRES 9 A 469 GLY SER GLY GLY VAL GLU GLU MET LYS ASN CYS SER PHE SEQRES 10 A 469 ASN THR THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU SEQRES 11 A 469 TYR ALA LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER SEQRES 12 A 469 GLU THR ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS SEQRES 13 A 469 ASN THR SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR SEQRES 14 A 469 PHE GLU PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY SEQRES 15 A 469 TYR ALA ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY SEQRES 16 A 469 THR GLY PRO CYS SER ASN VAL SER THR VAL GLN CYS THR SEQRES 17 A 469 HIS GLY ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU SEQRES 18 A 469 ASN GLY SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER SEQRES 19 A 469 GLU ASN LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS SEQRES 20 A 469 LEU HIS THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN SEQRES 21 A 469 ASN ASN THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN SEQRES 22 A 469 THR PHE TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS SEQRES 23 A 469 GLN ALA HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP SEQRES 24 A 469 THR LEU GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE SEQRES 25 A 469 PRO ASN LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY SEQRES 26 A 469 ASP MET GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY SEQRES 27 A 469 GLU PHE PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY SEQRES 28 A 469 THR TYR ASN GLY THR TYR ILE SER THR ASN SER SER ALA SEQRES 29 A 469 ASN SER THR SER THR ILE THR LEU GLN CYS ARG ILE LYS SEQRES 30 A 469 GLN ILE ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET SEQRES 31 A 469 TYR ALA PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER SEQRES 32 A 469 ASN ILE THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR SEQRES 33 A 469 ASN SER ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY SEQRES 34 A 469 ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR SEQRES 35 A 469 LYS VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR SEQRES 36 A 469 ARG CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 37 A 469 ARG SEQRES 1 B 469 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 B 469 VAL TRP LYS GLU ALA LYS THR THR LEU PHE CYS ALA SER SEQRES 3 B 469 ASP ALA ARG ALA TYR GLU LYS GLU VAL HIS ASN VAL TRP SEQRES 4 B 469 ALA THR HIS ALA CYS VAL PRO THR ASP PRO SER PRO GLN SEQRES 5 B 469 GLU LEU VAL LEU GLY ASN VAL THR GLU ASN PHE ASN MET SEQRES 6 B 469 TRP LYS ASN ASP MET VAL ASP GLN MET HIS GLU ASP ILE SEQRES 7 B 469 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 B 469 LEU THR PRO LEU CYS VAL THR LEU ILE CYS SER ASP ALA SEQRES 9 B 469 GLY SER GLY GLY VAL GLU GLU MET LYS ASN CYS SER PHE SEQRES 10 B 469 ASN THR THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU SEQRES 11 B 469 TYR ALA LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER SEQRES 12 B 469 GLU THR ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS SEQRES 13 B 469 ASN THR SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR SEQRES 14 B 469 PHE GLU PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY SEQRES 15 B 469 TYR ALA ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY SEQRES 16 B 469 THR GLY PRO CYS SER ASN VAL SER THR VAL GLN CYS THR SEQRES 17 B 469 HIS GLY ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU SEQRES 18 B 469 ASN GLY SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER SEQRES 19 B 469 GLU ASN LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS SEQRES 20 B 469 LEU HIS THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN SEQRES 21 B 469 ASN ASN THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN SEQRES 22 B 469 THR PHE TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS SEQRES 23 B 469 GLN ALA HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP SEQRES 24 B 469 THR LEU GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE SEQRES 25 B 469 PRO ASN LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY SEQRES 26 B 469 ASP MET GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY SEQRES 27 B 469 GLU PHE PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY SEQRES 28 B 469 THR TYR ASN GLY THR TYR ILE SER THR ASN SER SER ALA SEQRES 29 B 469 ASN SER THR SER THR ILE THR LEU GLN CYS ARG ILE LYS SEQRES 30 B 469 GLN ILE ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET SEQRES 31 B 469 TYR ALA PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER SEQRES 32 B 469 ASN ILE THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR SEQRES 33 B 469 ASN SER ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY SEQRES 34 B 469 ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR SEQRES 35 B 469 LYS VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR SEQRES 36 B 469 ARG CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 37 B 469 ARG SEQRES 1 C 469 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 C 469 VAL TRP LYS GLU ALA LYS THR THR LEU PHE CYS ALA SER SEQRES 3 C 469 ASP ALA ARG ALA TYR GLU LYS GLU VAL HIS ASN VAL TRP SEQRES 4 C 469 ALA THR HIS ALA CYS VAL PRO THR ASP PRO SER PRO GLN SEQRES 5 C 469 GLU LEU VAL LEU GLY ASN VAL THR GLU ASN PHE ASN MET SEQRES 6 C 469 TRP LYS ASN ASP MET VAL ASP GLN MET HIS GLU ASP ILE SEQRES 7 C 469 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 C 469 LEU THR PRO LEU CYS VAL THR LEU ILE CYS SER ASP ALA SEQRES 9 C 469 GLY SER GLY GLY VAL GLU GLU MET LYS ASN CYS SER PHE SEQRES 10 C 469 ASN THR THR THR GLU ILE ARG ASP LYS GLU LYS LYS GLU SEQRES 11 C 469 TYR ALA LEU PHE TYR LYS PRO ASP ILE VAL PRO LEU SER SEQRES 12 C 469 GLU THR ASN ASN THR SER GLU TYR ARG LEU ILE ASN CYS SEQRES 13 C 469 ASN THR SER ALA CYS THR GLN ALA CYS PRO LYS VAL THR SEQRES 14 C 469 PHE GLU PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY SEQRES 15 C 469 TYR ALA ILE LEU LYS CYS ASN ASP GLU THR PHE ASN GLY SEQRES 16 C 469 THR GLY PRO CYS SER ASN VAL SER THR VAL GLN CYS THR SEQRES 17 C 469 HIS GLY ILE ARG PRO VAL VAL SER THR GLN LEU LEU LEU SEQRES 18 C 469 ASN GLY SER LEU ALA GLU LYS GLU ILE VAL ILE ARG SER SEQRES 19 C 469 GLU ASN LEU THR ASN ASN ALA LYS ILE ILE ILE VAL HIS SEQRES 20 C 469 LEU HIS THR PRO VAL GLU ILE VAL CYS THR ARG PRO ASN SEQRES 21 C 469 ASN ASN THR ARG LYS SER VAL ARG ILE GLY PRO GLY GLN SEQRES 22 C 469 THR PHE TYR ALA THR GLY ASP ILE ILE GLY ASP ILE LYS SEQRES 23 C 469 GLN ALA HIS CYS ASN ILE SER GLU GLU LYS TRP ASN ASP SEQRES 24 C 469 THR LEU GLN LYS VAL GLY ILE GLU LEU GLN LYS HIS PHE SEQRES 25 C 469 PRO ASN LYS THR ILE LYS TYR ASN GLN SER ALA GLY GLY SEQRES 26 C 469 ASP MET GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY SEQRES 27 C 469 GLU PHE PHE TYR CYS ASN THR SER ASN LEU PHE ASN GLY SEQRES 28 C 469 THR TYR ASN GLY THR TYR ILE SER THR ASN SER SER ALA SEQRES 29 C 469 ASN SER THR SER THR ILE THR LEU GLN CYS ARG ILE LYS SEQRES 30 C 469 GLN ILE ILE ASN MET TRP GLN GLY VAL GLY ARG CYS MET SEQRES 31 C 469 TYR ALA PRO PRO ILE ALA GLY ASN ILE THR CYS ARG SER SEQRES 32 C 469 ASN ILE THR GLY LEU LEU LEU THR ARG ASP GLY GLY THR SEQRES 33 C 469 ASN SER ASN GLU THR GLU THR PHE ARG PRO ALA GLY GLY SEQRES 34 C 469 ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR SEQRES 35 C 469 LYS VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR SEQRES 36 C 469 ARG CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 37 C 469 ARG SEQRES 1 D 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 D 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 D 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 D 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 D 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 D 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 D 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 D 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 D 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 D 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 D 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 D 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 E 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 E 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 E 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 E 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 E 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 E 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 E 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 E 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 E 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 E 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 E 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 E 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 F 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 F 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 F 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 F 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 F 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 F 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 F 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 F 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 F 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 F 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 F 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 F 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 G 232 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 G 232 PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 G 232 TYR THR PHE THR GLY TYR TYR MET HIS TRP VAL ARG GLN SEQRES 4 G 232 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 G 232 PRO ASN SER GLY GLY THR ASN TYR ALA GLN LYS PHE GLN SEQRES 6 G 232 GLY ARG VAL THR MET THR ARG ASP THR SER ILE SER THR SEQRES 7 G 232 ALA TYR MET GLU LEU SER ARG LEU ARG SER ASP ASP THR SEQRES 8 G 232 ALA VAL TYR TYR CYS ALA ARG GLY GLY TRP ILE GLY LEU SEQRES 9 G 232 TYR TYR ASP SER SER GLY TYR PRO ASN PHE ASP TYR TRP SEQRES 10 G 232 GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR SEQRES 11 G 232 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 G 232 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 G 232 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 G 232 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 G 232 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 G 232 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 G 232 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 G 232 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS SEQRES 1 H 232 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 232 PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 H 232 TYR THR PHE THR GLY TYR TYR MET HIS TRP VAL ARG GLN SEQRES 4 H 232 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 H 232 PRO ASN SER GLY GLY THR ASN TYR ALA GLN LYS PHE GLN SEQRES 6 H 232 GLY ARG VAL THR MET THR ARG ASP THR SER ILE SER THR SEQRES 7 H 232 ALA TYR MET GLU LEU SER ARG LEU ARG SER ASP ASP THR SEQRES 8 H 232 ALA VAL TYR TYR CYS ALA ARG GLY GLY TRP ILE GLY LEU SEQRES 9 H 232 TYR TYR ASP SER SER GLY TYR PRO ASN PHE ASP TYR TRP SEQRES 10 H 232 GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR SEQRES 11 H 232 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 H 232 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 H 232 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 H 232 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 H 232 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 H 232 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 H 232 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 H 232 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS SEQRES 1 I 232 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 I 232 PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 I 232 TYR THR PHE THR GLY TYR TYR MET HIS TRP VAL ARG GLN SEQRES 4 I 232 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 I 232 PRO ASN SER GLY GLY THR ASN TYR ALA GLN LYS PHE GLN SEQRES 6 I 232 GLY ARG VAL THR MET THR ARG ASP THR SER ILE SER THR SEQRES 7 I 232 ALA TYR MET GLU LEU SER ARG LEU ARG SER ASP ASP THR SEQRES 8 I 232 ALA VAL TYR TYR CYS ALA ARG GLY GLY TRP ILE GLY LEU SEQRES 9 I 232 TYR TYR ASP SER SER GLY TYR PRO ASN PHE ASP TYR TRP SEQRES 10 I 232 GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR SEQRES 11 I 232 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 I 232 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 I 232 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 I 232 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 I 232 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 I 232 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 I 232 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 I 232 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS SEQRES 1 J 216 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 J 216 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 J 216 SER ASP VAL GLY SER TYR ASN LEU VAL SER TRP TYR GLN SEQRES 4 J 216 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR GLU SEQRES 5 J 216 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 J 216 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 J 216 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS CYS SEQRES 8 J 216 SER TYR ALA GLY SER SER THR VAL ILE PHE GLY GLY GLY SEQRES 9 J 216 THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ASN PRO SEQRES 10 J 216 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11 J 216 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12 J 216 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SEQRES 13 J 216 SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER SEQRES 14 J 216 LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SEQRES 15 J 216 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16 J 216 SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS SEQRES 17 J 216 THR VAL ALA PRO THR GLU CYS SER SEQRES 1 K 216 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 K 216 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 K 216 SER ASP VAL GLY SER TYR ASN LEU VAL SER TRP TYR GLN SEQRES 4 K 216 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR GLU SEQRES 5 K 216 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 K 216 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 K 216 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS CYS SEQRES 8 K 216 SER TYR ALA GLY SER SER THR VAL ILE PHE GLY GLY GLY SEQRES 9 K 216 THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ASN PRO SEQRES 10 K 216 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11 K 216 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12 K 216 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SEQRES 13 K 216 SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER SEQRES 14 K 216 LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SEQRES 15 K 216 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16 K 216 SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS SEQRES 17 K 216 THR VAL ALA PRO THR GLU CYS SER SEQRES 1 L 216 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 L 216 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 L 216 SER ASP VAL GLY SER TYR ASN LEU VAL SER TRP TYR GLN SEQRES 4 L 216 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR GLU SEQRES 5 L 216 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 L 216 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 L 216 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS CYS SEQRES 8 L 216 SER TYR ALA GLY SER SER THR VAL ILE PHE GLY GLY GLY SEQRES 9 L 216 THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ASN PRO SEQRES 10 L 216 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11 L 216 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12 L 216 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SEQRES 13 L 216 SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER SEQRES 14 L 216 LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SEQRES 15 L 216 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16 L 216 SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS SEQRES 17 L 216 THR VAL ALA PRO THR GLU CYS SER HET NAG M 1 14 HET NAG M 2 14 HET BMA M 3 11 HET MAN M 4 11 HET MAN M 5 11 HET NAG N 1 14 HET NAG N 2 14 HET BMA N 3 11 HET MAN N 4 11 HET MAN N 5 11 HET MAN N 6 11 HET MAN N 7 11 HET MAN N 8 11 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET BMA R 3 11 HET MAN R 4 11 HET MAN R 5 11 HET NAG S 1 14 HET NAG S 2 14 HET BMA S 3 11 HET MAN S 4 11 HET MAN S 5 11 HET MAN S 6 11 HET MAN S 7 11 HET MAN S 8 11 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET BMA W 3 11 HET MAN W 4 11 HET MAN W 5 11 HET NAG X 1 14 HET NAG X 2 14 HET BMA X 3 11 HET MAN X 4 11 HET MAN X 5 11 HET MAN X 6 11 HET MAN X 7 11 HET MAN X 8 11 HET NAG Y 1 14 HET NAG Y 2 14 HET BMA Y 3 11 HET NAG Z 1 14 HET NAG Z 2 14 HET NAG a 1 14 HET NAG a 2 14 HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG A 604 14 HET NAG A 605 14 HET NAG A 606 14 HET NAG A 607 14 HET NAG A 608 14 HET NAG A 609 14 HET NAG B 601 14 HET NAG B 602 14 HET NAG B 603 14 HET NAG B 604 14 HET NAG B 605 14 HET NAG B 606 14 HET NAG B 607 14 HET NAG B 608 14 HET NAG B 609 14 HET NAG C 601 14 HET NAG C 602 14 HET NAG C 603 14 HET NAG C 604 14 HET NAG C 605 14 HET NAG C 606 14 HET NAG C 607 14 HET NAG C 608 14 HET NAG C 609 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 13 NAG 57(C8 H15 N O6) FORMUL 13 BMA 9(C6 H12 O6) FORMUL 13 MAN 21(C6 H12 O6) HELIX 1 AA1 ALA A 58 LYS A 63 5 6 HELIX 2 AA2 ASP A 99 LEU A 116 1 18 HELIX 3 AA3 TYR A 177 PRO A 179 5 3 HELIX 4 AA4 GLU A 335 GLN A 350 1 16 HELIX 5 AA5 ARG A 476 SER A 481 1 6 HELIX 6 AA6 ALA B 58 TYR B 61 5 4 HELIX 7 AA7 TRP B 69 CYS B 74 1 6 HELIX 8 AA8 ASN B 98 LEU B 116 1 19 HELIX 9 AA9 TYR B 177 PRO B 179 5 3 HELIX 10 AB1 GLU B 335 GLN B 350 1 16 HELIX 11 AB2 ASP B 368 THR B 373 1 6 HELIX 12 AB3 SER B 405 SER B 409 5 5 HELIX 13 AB4 MET B 475 LEU B 483 1 9 HELIX 14 AB5 ASP C 99 SER C 115 1 17 HELIX 15 AB6 GLU C 335 GLN C 350 1 16 HELIX 16 AB7 ASP C 368 THR C 373 1 6 HELIX 17 AB8 MET C 475 LEU C 483 1 9 HELIX 18 AB9 THR D 529 SER D 534 1 6 HELIX 19 AC1 GLN D 540 LEU D 544 5 5 HELIX 20 AC2 ILE D 573 TRP D 596 1 24 HELIX 21 AC3 ASN D 611 SER D 615 5 5 HELIX 22 AC4 LEU D 619 ASN D 625 1 7 HELIX 23 AC5 THR D 627 SER D 636 1 10 HELIX 24 AC6 THR D 639 ASP D 664 1 26 HELIX 25 AC7 THR E 529 SER E 534 1 6 HELIX 26 AC8 THR E 536 ALA E 541 1 6 HELIX 27 AC9 ARG E 542 LEU E 545 5 4 HELIX 28 AD1 VAL E 570 TRP E 596 1 27 HELIX 29 AD2 ASN E 611 SER E 615 5 5 HELIX 30 AD3 ASN E 618 MET E 626 1 9 HELIX 31 AD4 THR E 627 SER E 636 1 10 HELIX 32 AD5 TYR E 638 ALA E 662 1 25 HELIX 33 AD6 THR F 529 SER F 534 1 6 HELIX 34 AD7 MET F 535 GLN F 540 5 6 HELIX 35 AD8 GLY F 572 TRP F 596 1 25 HELIX 36 AD9 ASN F 618 MET F 626 1 9 HELIX 37 AE1 THR F 627 SER F 636 1 10 HELIX 38 AE2 TYR F 638 ASP F 664 1 27 HELIX 39 AE3 THR G 28 THR G 30 5 3 HELIX 40 AE4 THR H 28 THR H 30 5 3 HELIX 41 AE5 ARG H 87 THR H 91 5 5 HELIX 42 AE6 THR I 28 THR I 30 5 3 HELIX 43 AE7 ARG I 87 THR I 91 5 5 HELIX 44 AE8 GLN J 81 GLU J 85 5 5 HELIX 45 AE9 GLN K 81 GLU K 85 5 5 HELIX 46 AF1 GLN L 81 GLU L 85 5 5 SHEET 1 AA1 3 LEU A 494 THR A 499 0 SHEET 2 AA1 3 TRP A 35 TYR A 40 -1 N TYR A 39 O GLY A 495 SHEET 3 AA1 3 ILE D 603 PRO D 609 -1 O CYS D 604 N VAL A 38 SHEET 1 AA2 5 TRP A 45 GLU A 47 0 SHEET 2 AA2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AA2 5 TYR A 223 CYS A 228 -1 N ALA A 224 O VAL A 489 SHEET 4 AA2 5 VAL A 242 VAL A 245 -1 O SER A 243 N LYS A 227 SHEET 5 AA2 5 GLU A 83 VAL A 85 -1 N LEU A 84 O THR A 244 SHEET 1 AA3 3 VAL A 75 PRO A 76 0 SHEET 2 AA3 3 ALA A 55 SER A 56 1 N SER A 56 O VAL A 75 SHEET 3 AA3 3 ILE A 215 HIS A 216 -1 O HIS A 216 N ALA A 55 SHEET 1 AA4 2 GLU A 91 ASN A 94 0 SHEET 2 AA4 2 THR A 236 CYS A 239 -1 O GLY A 237 N PHE A 93 SHEET 1 AA5 2 PHE A 159 THR A 162 0 SHEET 2 AA5 2 GLU A 169 GLU A 172 -1 O GLU A 172 N PHE A 159 SHEET 1 AA6 2 ILE A 181 PRO A 183 0 SHEET 2 AA6 2 TYR A 191 LEU A 193 -1 O ARG A 192 N VAL A 182 SHEET 1 AA7 6 VAL A 271 ARG A 273 0 SHEET 2 AA7 6 ILE A 284 HIS A 287 -1 O ILE A 285 N ARG A 273 SHEET 3 AA7 6 GLY A 451 ARG A 456 -1 O LEU A 452 N VAL A 286 SHEET 4 AA7 6 THR A 465 PRO A 470 -1 O ARG A 469 N THR A 455 SHEET 5 AA7 6 THR A 357 TYR A 361 1 N LYS A 360 O GLU A 466 SHEET 6 AA7 6 GLY A 393 TYR A 395 -1 O GLY A 393 N TYR A 361 SHEET 1 AA8 4 THR A 413 CYS A 418 0 SHEET 2 AA8 4 ALA A 329 SER A 334 -1 N ILE A 333 O ILE A 414 SHEET 3 AA8 4 GLU A 293 CYS A 296 -1 N VAL A 295 O ASN A 332 SHEET 4 AA8 4 SER A 447 ASN A 448 -1 O SER A 447 N ILE A 294 SHEET 1 AA9 2 ARG A 304 ILE A 309 0 SHEET 2 AA9 2 GLN A 315 THR A 320 -1 O PHE A 317 N VAL A 307 SHEET 1 AB1 2 PHE A 382 PHE A 383 0 SHEET 2 AB1 2 ILE A 420 LYS A 421 -1 O LYS A 421 N PHE A 382 SHEET 1 AB2 3 LEU B 494 THR B 499 0 SHEET 2 AB2 3 TRP B 35 TYR B 40 -1 N TRP B 35 O THR B 499 SHEET 3 AB2 3 ILE E 603 PRO E 609 -1 O CYS E 604 N VAL B 38 SHEET 1 AB3 5 TRP B 45 GLU B 47 0 SHEET 2 AB3 5 TYR B 486 ILE B 491 -1 O LYS B 490 N LYS B 46 SHEET 3 AB3 5 TYR B 223 LYS B 227 -1 N ALA B 224 O VAL B 489 SHEET 4 AB3 5 SER B 243 VAL B 245 -1 O SER B 243 N LYS B 227 SHEET 5 AB3 5 GLU B 83 VAL B 85 -1 N LEU B 84 O THR B 244 SHEET 1 AB4 2 ALA B 55 SER B 56 0 SHEET 2 AB4 2 ILE B 215 HIS B 216 -1 O HIS B 216 N ALA B 55 SHEET 1 AB5 2 GLU B 91 ASN B 94 0 SHEET 2 AB5 2 THR B 236 CYS B 239 -1 O GLY B 237 N PHE B 93 SHEET 1 AB6 2 PHE B 159 THR B 162 0 SHEET 2 AB6 2 GLU B 169 GLU B 172 -1 O GLU B 172 N PHE B 159 SHEET 1 AB7 2 ILE B 181 VAL B 182 0 SHEET 2 AB7 2 ARG B 192 LEU B 193 -1 O ARG B 192 N VAL B 182 SHEET 1 AB8 6 VAL B 271 ARG B 273 0 SHEET 2 AB8 6 ILE B 284 HIS B 287 -1 O HIS B 287 N VAL B 271 SHEET 3 AB8 6 GLY B 451 THR B 455 -1 O LEU B 452 N VAL B 286 SHEET 4 AB8 6 THR B 465 PRO B 470 -1 O ARG B 469 N THR B 455 SHEET 5 AB8 6 THR B 357 TYR B 361 1 N LYS B 360 O PHE B 468 SHEET 6 AB8 6 GLY B 393 TYR B 395 -1 O TYR B 395 N ILE B 358 SHEET 1 AB9 6 HIS B 374 ASN B 377 0 SHEET 2 AB9 6 PHE B 382 CYS B 385 -1 O CYS B 385 N HIS B 374 SHEET 3 AB9 6 THR B 413 ILE B 420 -1 O ARG B 419 N TYR B 384 SHEET 4 AB9 6 HIS B 330 SER B 334 -1 N ILE B 333 O ILE B 414 SHEET 5 AB9 6 GLU B 293 CYS B 296 -1 N VAL B 295 O ASN B 332 SHEET 6 AB9 6 SER B 447 ASN B 448 -1 O SER B 447 N ILE B 294 SHEET 1 AC1 2 ARG B 304 ARG B 308 0 SHEET 2 AC1 2 THR B 316 THR B 320 -1 O PHE B 317 N VAL B 307 SHEET 1 AC2 2 ILE B 423 ILE B 424 0 SHEET 2 AC2 2 MET B 434 TYR B 435 -1 O MET B 434 N ILE B 424 SHEET 1 AC3 3 LEU C 494 THR C 499 0 SHEET 2 AC3 3 TRP C 35 TYR C 40 -1 N TRP C 35 O THR C 499 SHEET 3 AC3 3 ILE F 603 PRO F 609 -1 O CYS F 604 N VAL C 38 SHEET 1 AC4 5 TRP C 45 GLU C 47 0 SHEET 2 AC4 5 TYR C 486 ILE C 491 -1 O LYS C 490 N LYS C 46 SHEET 3 AC4 5 TYR C 223 CYS C 228 -1 N LEU C 226 O LYS C 487 SHEET 4 AC4 5 VAL C 242 VAL C 245 -1 O VAL C 245 N ILE C 225 SHEET 5 AC4 5 GLU C 83 VAL C 85 -1 N LEU C 84 O THR C 244 SHEET 1 AC5 2 ALA C 55 SER C 56 0 SHEET 2 AC5 2 VAL C 75 PRO C 76 1 O VAL C 75 N SER C 56 SHEET 1 AC6 2 GLU C 91 PHE C 93 0 SHEET 2 AC6 2 GLY C 237 CYS C 239 -1 O GLY C 237 N PHE C 93 SHEET 1 AC7 3 LEU C 129 ILE C 130 0 SHEET 2 AC7 3 GLU C 190 LEU C 193 -1 O TYR C 191 N LEU C 129 SHEET 3 AC7 3 ILE C 181 VAL C 182 -1 N VAL C 182 O ARG C 192 SHEET 1 AC8 2 MET C 154 LYS C 155 0 SHEET 2 AC8 2 PHE C 176 TYR C 177 -1 O PHE C 176 N LYS C 155 SHEET 1 AC9 2 PHE C 159 THR C 162 0 SHEET 2 AC9 2 GLU C 169 GLU C 172 -1 O GLU C 172 N PHE C 159 SHEET 1 AD1 3 THR C 202 GLN C 203 0 SHEET 2 AD1 3 MET C 434 TYR C 435 1 O TYR C 435 N THR C 202 SHEET 3 AD1 3 ILE C 423 ILE C 424 -1 N ILE C 424 O MET C 434 SHEET 1 AD2 6 VAL C 271 ARG C 273 0 SHEET 2 AD2 6 ILE C 284 HIS C 287 -1 O ILE C 285 N ARG C 273 SHEET 3 AD2 6 GLY C 451 ARG C 456 -1 O LEU C 452 N VAL C 286 SHEET 4 AD2 6 THR C 465 PRO C 470 -1 O ARG C 469 N THR C 455 SHEET 5 AD2 6 THR C 357 TYR C 361 1 N LYS C 360 O PHE C 468 SHEET 6 AD2 6 GLY C 393 TYR C 395 -1 O TYR C 395 N ILE C 358 SHEET 1 AD3 5 ILE C 294 THR C 297 0 SHEET 2 AD3 5 HIS C 330 SER C 334 -1 O ASN C 332 N VAL C 295 SHEET 3 AD3 5 THR C 413 LYS C 421 -1 O ILE C 414 N ILE C 333 SHEET 4 AD3 5 GLU C 381 CYS C 385 -1 N TYR C 384 O ARG C 419 SHEET 5 AD3 5 HIS C 374 CYS C 378 -1 N CYS C 378 O GLU C 381 SHEET 1 AD4 2 ARG C 304 GLY C 312 0 SHEET 2 AD4 2 GLN C 315 THR C 320 -1 O PHE C 317 N VAL C 307 SHEET 1 AD5 4 GLN G 3 GLN G 6 0 SHEET 2 AD5 4 SER G 17 SER G 25 -1 O LYS G 23 N VAL G 5 SHEET 3 AD5 4 THR G 78 SER G 84 -1 O ALA G 79 N CYS G 22 SHEET 4 AD5 4 VAL G 68 ASP G 73 -1 N THR G 69 O GLU G 82 SHEET 1 AD6 5 GLU G 10 LYS G 12 0 SHEET 2 AD6 5 THR G 121 VAL G 125 1 O THR G 124 N GLU G 10 SHEET 3 AD6 5 ALA G 92 TRP G 101 -1 N ALA G 92 O VAL G 123 SHEET 4 AD6 5 TYR G 32 GLN G 39 -1 N TYR G 33 O GLY G 99 SHEET 5 AD6 5 LEU G 45 TRP G 47 -1 O GLU G 46 N ARG G 38 SHEET 1 AD7 2 ILE G 51 ASN G 52 0 SHEET 2 AD7 2 GLY G 57 THR G 58 -1 O GLY G 57 N ASN G 52 SHEET 1 AD8 4 GLN H 3 GLN H 6 0 SHEET 2 AD8 4 SER H 17 SER H 25 -1 O LYS H 23 N VAL H 5 SHEET 3 AD8 4 THR H 78 SER H 84 -1 O ALA H 79 N CYS H 22 SHEET 4 AD8 4 VAL H 68 ASP H 73 -1 N THR H 71 O TYR H 80 SHEET 1 AD9 6 GLU H 10 LYS H 12 0 SHEET 2 AD9 6 THR H 121 VAL H 125 1 O THR H 124 N LYS H 12 SHEET 3 AD9 6 ALA H 92 TRP H 101 -1 N TYR H 94 O THR H 121 SHEET 4 AD9 6 TYR H 32 GLN H 39 -1 N TYR H 33 O GLY H 99 SHEET 5 AD9 6 LEU H 45 ILE H 51 -1 O MET H 48 N TRP H 36 SHEET 6 AD9 6 THR H 58 ASN H 59 -1 O ASN H 59 N TRP H 50 SHEET 1 AE1 4 GLN I 3 VAL I 5 0 SHEET 2 AE1 4 SER I 17 SER I 25 -1 O SER I 25 N GLN I 3 SHEET 3 AE1 4 THR I 78 SER I 84 -1 O ALA I 79 N CYS I 22 SHEET 4 AE1 4 VAL I 68 ASP I 73 -1 N THR I 69 O GLU I 82 SHEET 1 AE2 5 GLU I 10 LYS I 12 0 SHEET 2 AE2 5 THR I 121 VAL I 125 1 O THR I 124 N GLU I 10 SHEET 3 AE2 5 ALA I 92 TRP I 101 -1 N ALA I 92 O VAL I 123 SHEET 4 AE2 5 TYR I 32 GLN I 39 -1 N HIS I 35 O ALA I 97 SHEET 5 AE2 5 LEU I 45 ILE I 51 -1 O MET I 48 N TRP I 36 SHEET 1 AE3 5 SER J 9 GLY J 12 0 SHEET 2 AE3 5 THR J 105 VAL J 109 1 O THR J 108 N GLY J 12 SHEET 3 AE3 5 ASP J 87 TYR J 93 -1 N TYR J 88 O THR J 105 SHEET 4 AE3 5 VAL J 35 GLN J 40 -1 N SER J 36 O CYS J 91 SHEET 5 AE3 5 LYS J 47 ILE J 50 -1 O MET J 49 N TRP J 37 SHEET 1 AE4 4 SER J 9 GLY J 12 0 SHEET 2 AE4 4 THR J 105 VAL J 109 1 O THR J 108 N GLY J 12 SHEET 3 AE4 4 ASP J 87 TYR J 93 -1 N TYR J 88 O THR J 105 SHEET 4 AE4 4 VAL J 99 PHE J 101 -1 O ILE J 100 N SER J 92 SHEET 1 AE5 3 ILE J 18 CYS J 22 0 SHEET 2 AE5 3 THR J 72 ILE J 77 -1 O LEU J 75 N ILE J 20 SHEET 3 AE5 3 SER J 65 SER J 69 -1 N SER J 65 O THR J 76 SHEET 1 AE6 2 SER K 11 GLY K 12 0 SHEET 2 AE6 2 THR K 108 VAL K 109 1 O THR K 108 N GLY K 12 SHEET 1 AE7 3 SER K 17 THR K 23 0 SHEET 2 AE7 3 THR K 72 SER K 78 -1 O LEU K 75 N ILE K 20 SHEET 3 AE7 3 PHE K 64 SER K 69 -1 N SER K 65 O THR K 76 SHEET 1 AE8 4 LYS K 47 ILE K 50 0 SHEET 2 AE8 4 VAL K 35 GLN K 40 -1 N GLN K 39 O LYS K 47 SHEET 3 AE8 4 ASP K 87 TYR K 93 -1 O TYR K 89 N TYR K 38 SHEET 4 AE8 4 VAL K 99 PHE K 101 -1 O ILE K 100 N SER K 92 SHEET 1 AE9 4 LYS K 47 ILE K 50 0 SHEET 2 AE9 4 VAL K 35 GLN K 40 -1 N GLN K 39 O LYS K 47 SHEET 3 AE9 4 ASP K 87 TYR K 93 -1 O TYR K 89 N TYR K 38 SHEET 4 AE9 4 THR K 105 LYS K 106 -1 O THR K 105 N TYR K 88 SHEET 1 AF1 5 SER L 9 GLY L 12 0 SHEET 2 AF1 5 THR L 105 VAL L 109 1 O LYS L 106 N VAL L 10 SHEET 3 AF1 5 ASP L 87 TYR L 93 -1 N TYR L 88 O THR L 105 SHEET 4 AF1 5 VAL L 35 GLN L 40 -1 N SER L 36 O CYS L 91 SHEET 5 AF1 5 LYS L 47 LEU L 48 -1 O LYS L 47 N GLN L 39 SHEET 1 AF2 4 SER L 9 GLY L 12 0 SHEET 2 AF2 4 THR L 105 VAL L 109 1 O LYS L 106 N VAL L 10 SHEET 3 AF2 4 ASP L 87 TYR L 93 -1 N TYR L 88 O THR L 105 SHEET 4 AF2 4 VAL L 99 PHE L 101 -1 O ILE L 100 N SER L 92 SHEET 1 AF3 3 ILE L 18 THR L 23 0 SHEET 2 AF3 3 THR L 72 ILE L 77 -1 O LEU L 75 N ILE L 20 SHEET 3 AF3 3 PHE L 64 SER L 69 -1 N SER L 65 O THR L 76 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.03 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.03 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.03 SSBOND 4 CYS A 131 CYS A 157 1555 1555 2.02 SSBOND 5 CYS A 201 CYS A 433 1555 1555 2.04 SSBOND 6 CYS A 218 CYS A 247 1555 1555 2.05 SSBOND 7 CYS A 228 CYS A 239 1555 1555 2.03 SSBOND 8 CYS A 296 CYS A 331 1555 1555 2.03 SSBOND 9 CYS A 378 CYS A 445 1555 1555 2.03 SSBOND 10 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 11 CYS A 501 CYS D 605 1555 1555 2.03 SSBOND 12 CYS B 54 CYS B 74 1555 1555 2.03 SSBOND 13 CYS B 119 CYS B 205 1555 1555 2.03 SSBOND 14 CYS B 126 CYS B 196 1555 1555 2.03 SSBOND 15 CYS B 131 CYS B 157 1555 1555 2.03 SSBOND 16 CYS B 218 CYS B 247 1555 1555 2.03 SSBOND 17 CYS B 228 CYS B 239 1555 1555 2.04 SSBOND 18 CYS B 296 CYS B 331 1555 1555 2.03 SSBOND 19 CYS B 385 CYS B 418 1555 1555 2.03 SSBOND 20 CYS B 501 CYS E 605 1555 1555 2.03 SSBOND 21 CYS C 54 CYS C 74 1555 1555 2.03 SSBOND 22 CYS C 119 CYS C 205 1555 1555 2.03 SSBOND 23 CYS C 126 CYS C 196 1555 1555 2.03 SSBOND 24 CYS C 131 CYS C 157 1555 1555 2.03 SSBOND 25 CYS C 218 CYS C 247 1555 1555 2.03 SSBOND 26 CYS C 228 CYS C 239 1555 1555 2.03 SSBOND 27 CYS C 296 CYS C 331 1555 1555 2.03 SSBOND 28 CYS C 385 CYS C 418 1555 1555 2.06 SSBOND 29 CYS C 501 CYS F 605 1555 1555 2.03 SSBOND 30 CYS D 598 CYS D 604 1555 1555 2.01 SSBOND 31 CYS E 598 CYS E 604 1555 1555 2.03 SSBOND 32 CYS F 598 CYS F 604 1555 1555 2.03 SSBOND 33 CYS G 22 CYS G 96 1555 1555 2.04 SSBOND 34 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 35 CYS I 22 CYS I 96 1555 1555 2.03 SSBOND 36 CYS J 22 CYS J 90 1555 1555 2.03 SSBOND 37 CYS K 22 CYS K 90 1555 1555 2.03 SSBOND 38 CYS L 22 CYS L 90 1555 1555 2.03 LINK ND2 ASN A 88 C1 NAG A 606 1555 1555 1.46 LINK ND2 ASN A 156 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN A 160 C1 NAG A 603 1555 1555 1.44 LINK ND2 ASN A 197 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN A 241 C1 NAG A 607 1555 1555 1.44 LINK ND2 ASN A 262 C1 NAG M 1 1555 1555 1.43 LINK ND2 ASN A 276 C1 NAG A 605 1555 1555 1.45 LINK ND2 ASN A 300 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN A 332 C1 NAG N 1 1555 1555 1.43 LINK ND2 ASN A 362 C1 NAG A 604 1555 1555 1.45 LINK ND2 ASN A 386 C1 NAG A 601 1555 1555 1.44 LINK ND2 ASN A 392 C1 NAG A 602 1555 1555 1.44 LINK ND2 ASN A 442 C1 NAG A 609 1555 1555 1.44 LINK ND2 ASN A 448 C1 NAG A 608 1555 1555 1.43 LINK ND2 ASN B 88 C1 NAG B 606 1555 1555 1.45 LINK ND2 ASN B 156 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN B 160 C1 NAG B 603 1555 1555 1.44 LINK ND2 ASN B 197 C1 NAG a 1 1555 1555 1.43 LINK ND2 ASN B 241 C1 NAG B 607 1555 1555 1.44 LINK ND2 ASN B 262 C1 NAG W 1 1555 1555 1.43 LINK ND2 ASN B 276 C1 NAG B 605 1555 1555 1.45 LINK ND2 ASN B 300 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN B 332 C1 NAG X 1 1555 1555 1.43 LINK ND2 ASN B 362 C1 NAG B 604 1555 1555 1.45 LINK ND2 ASN B 386 C1 NAG B 601 1555 1555 1.44 LINK ND2 ASN B 392 C1 NAG B 602 1555 1555 1.44 LINK ND2 ASN B 442 C1 NAG B 609 1555 1555 1.44 LINK ND2 ASN B 448 C1 NAG B 608 1555 1555 1.44 LINK ND2 ASN C 88 C1 NAG C 606 1555 1555 1.46 LINK ND2 ASN C 156 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN C 160 C1 NAG C 603 1555 1555 1.44 LINK ND2 ASN C 197 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN C 241 C1 NAG C 607 1555 1555 1.44 LINK ND2 ASN C 262 C1 NAG R 1 1555 1555 1.43 LINK ND2 ASN C 276 C1 NAG C 605 1555 1555 1.45 LINK ND2 ASN C 300 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN C 332 C1 NAG S 1 1555 1555 1.43 LINK ND2 ASN C 362 C1 NAG C 604 1555 1555 1.45 LINK ND2 ASN C 386 C1 NAG C 601 1555 1555 1.43 LINK ND2 ASN C 392 C1 NAG C 602 1555 1555 1.44 LINK ND2 ASN C 442 C1 NAG C 609 1555 1555 1.44 LINK ND2 ASN C 448 C1 NAG C 608 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.45 LINK O3 BMA M 3 C1 MAN M 4 1555 1555 1.45 LINK O6 BMA M 3 C1 MAN M 5 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG N 2 C1 BMA N 3 1555 1555 1.43 LINK O3 BMA N 3 C1 MAN N 4 1555 1555 1.44 LINK O6 BMA N 3 C1 MAN N 6 1555 1555 1.44 LINK O2 MAN N 4 C1 MAN N 5 1555 1555 1.44 LINK O3 MAN N 6 C1 MAN N 7 1555 1555 1.44 LINK O6 MAN N 6 C1 MAN N 8 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.45 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG R 2 C1 BMA R 3 1555 1555 1.45 LINK O3 BMA R 3 C1 MAN R 4 1555 1555 1.44 LINK O6 BMA R 3 C1 MAN R 5 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG S 2 C1 BMA S 3 1555 1555 1.43 LINK O3 BMA S 3 C1 MAN S 4 1555 1555 1.44 LINK O6 BMA S 3 C1 MAN S 6 1555 1555 1.44 LINK O2 MAN S 4 C1 MAN S 5 1555 1555 1.44 LINK O3 MAN S 6 C1 MAN S 7 1555 1555 1.44 LINK O6 MAN S 6 C1 MAN S 8 1555 1555 1.45 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.45 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.45 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.45 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG W 2 C1 BMA W 3 1555 1555 1.45 LINK O3 BMA W 3 C1 MAN W 4 1555 1555 1.44 LINK O6 BMA W 3 C1 MAN W 5 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.45 LINK O4 NAG X 2 C1 BMA X 3 1555 1555 1.44 LINK O3 BMA X 3 C1 MAN X 4 1555 1555 1.44 LINK O6 BMA X 3 C1 MAN X 6 1555 1555 1.44 LINK O2 MAN X 4 C1 MAN X 5 1555 1555 1.45 LINK O3 MAN X 6 C1 MAN X 7 1555 1555 1.45 LINK O6 MAN X 6 C1 MAN X 8 1555 1555 1.45 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.44 LINK O4 NAG Y 2 C1 BMA Y 3 1555 1555 1.45 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000