HEADER VIRAL PROTEIN 11-APR-24 9BDG TITLE INFLUENZA A VIRUS HEMAGGLUTININ H3/DARWIN/6/2021 IN COMPLEX WITH FAB TITLE 2 ADI-85647 COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: A, B, C; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: FAB ADI-85647 HEAVY CHAIN; COMPND 7 CHAIN: D, E, F; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: IG-LIKE DOMAIN-CONTAINING PROTEIN; COMPND 11 CHAIN: G, H, I; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 11320; SOURCE 4 GENE: HA; SOURCE 5 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_COMMON: HUMAN; SOURCE 15 ORGANISM_TAXID: 9606; SOURCE 16 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS HEMAGGLUTININ, INFLUENZA A, ANTIBODY, FAB, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR A.S.FERREIRA RAMOS,G.BAJIC REVDAT 1 13-NOV-24 9BDG 0 JRNL AUTH D.MAURER,A.S.FERREIRA RAMOS,G.BAJIC,G.S.AARON JRNL TITL INFLUENZA A VIRUS HEMAGGLUTININ H3/DARWIN/6/2021 IN COMPLEX JRNL TITL 2 WITH FAB ADI-85647 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.01 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.010 REMARK 3 NUMBER OF PARTICLES : 315433 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING ONLY REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9BDG COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 12-APR-24. REMARK 100 THE DEPOSITION ID IS D_1000283007. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : INFLUENZA A VIRUS HEMAGGLUTININ REMARK 245 H3/DARWIN/6/2021 IN COMPLEX REMARK 245 WITH FAB ADI-85647 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : SOLARUS PLASMA CLEANER MACHINE REMARK 245 (GATAN) REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : OTHER REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5244.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLN A 1 REMARK 465 LYS A 2 REMARK 465 ILE A 3 REMARK 465 PRO A 4 REMARK 465 GLY A 5 REMARK 465 ASN A 6 REMARK 465 ASP A 7 REMARK 465 ASN A 8 REMARK 465 SER A 9 REMARK 465 THR A 10 REMARK 465 ALA A 11 REMARK 465 THR A 12 REMARK 465 LEU A 13 REMARK 465 CYS A 14 REMARK 465 LEU A 15 REMARK 465 GLY A 16 REMARK 465 HIS A 17 REMARK 465 HIS A 18 REMARK 465 ALA A 19 REMARK 465 VAL A 20 REMARK 465 GLU A 325 REMARK 465 LYS A 326 REMARK 465 GLN A 327 REMARK 465 THR A 328 REMARK 465 ARG A 329 REMARK 465 GLY A 330 REMARK 465 ILE A 331 REMARK 465 PHE A 332 REMARK 465 GLY A 333 REMARK 465 ALA A 334 REMARK 465 ILE A 335 REMARK 465 ALA A 336 REMARK 465 GLY A 337 REMARK 465 PHE A 338 REMARK 465 ILE A 339 REMARK 465 GLU A 340 REMARK 465 ASN A 341 REMARK 465 GLY A 342 REMARK 465 TRP A 343 REMARK 465 GLU A 344 REMARK 465 GLY A 345 REMARK 465 MET A 346 REMARK 465 VAL A 347 REMARK 465 ASP A 348 REMARK 465 GLY A 349 REMARK 465 TRP A 350 REMARK 465 TYR A 351 REMARK 465 GLY A 352 REMARK 465 PHE A 353 REMARK 465 ARG A 354 REMARK 465 TRP A 355 REMARK 465 GLN A 356 REMARK 465 ASN A 357 REMARK 465 SER A 358 REMARK 465 GLU A 359 REMARK 465 GLY A 360 REMARK 465 ARG A 361 REMARK 465 GLY A 362 REMARK 465 GLN A 363 REMARK 465 ASN A 445 REMARK 465 LYS A 446 REMARK 465 LEU A 447 REMARK 465 PHE A 448 REMARK 465 GLU A 449 REMARK 465 LYS A 450 REMARK 465 THR A 451 REMARK 465 LYS A 452 REMARK 465 LYS A 453 REMARK 465 GLN A 454 REMARK 465 LEU A 455 REMARK 465 ARG A 456 REMARK 465 GLU A 457 REMARK 465 ASN A 458 REMARK 465 ALA A 459 REMARK 465 GLU A 460 REMARK 465 ASP A 461 REMARK 465 MET A 462 REMARK 465 GLY A 463 REMARK 465 ASN A 464 REMARK 465 GLY A 465 REMARK 465 CYS A 466 REMARK 465 PHE A 467 REMARK 465 LYS A 468 REMARK 465 ILE A 469 REMARK 465 TYR A 470 REMARK 465 HIS A 471 REMARK 465 LYS A 472 REMARK 465 CYS A 473 REMARK 465 ASP A 474 REMARK 465 ASN A 475 REMARK 465 ALA A 476 REMARK 465 CYS A 477 REMARK 465 ILE A 478 REMARK 465 GLY A 479 REMARK 465 SER A 480 REMARK 465 ILE A 481 REMARK 465 ARG A 482 REMARK 465 ASN A 483 REMARK 465 GLU A 484 REMARK 465 THR A 485 REMARK 465 TYR A 486 REMARK 465 ASP A 487 REMARK 465 HIS A 488 REMARK 465 ASN A 489 REMARK 465 VAL A 490 REMARK 465 TYR A 491 REMARK 465 ARG A 492 REMARK 465 ASP A 493 REMARK 465 GLU A 494 REMARK 465 ALA A 495 REMARK 465 LEU A 496 REMARK 465 ASN A 497 REMARK 465 ASN A 498 REMARK 465 ARG A 499 REMARK 465 PHE A 500 REMARK 465 GLN A 501 REMARK 465 ILE A 502 REMARK 465 LYS A 503 REMARK 465 GLY A 504 REMARK 465 ALA A 505 REMARK 465 GLY A 506 REMARK 465 SER A 507 REMARK 465 SER A 508 REMARK 465 LEU A 509 REMARK 465 GLU A 510 REMARK 465 VAL A 511 REMARK 465 LEU A 512 REMARK 465 PHE A 513 REMARK 465 GLN A 514 REMARK 465 GLN B 1 REMARK 465 LYS B 2 REMARK 465 ILE B 3 REMARK 465 PRO B 4 REMARK 465 GLY B 5 REMARK 465 ASN B 6 REMARK 465 ASP B 7 REMARK 465 ASN B 8 REMARK 465 SER B 9 REMARK 465 THR B 10 REMARK 465 ALA B 11 REMARK 465 THR B 12 REMARK 465 LEU B 13 REMARK 465 CYS B 14 REMARK 465 LEU B 15 REMARK 465 GLY B 16 REMARK 465 HIS B 17 REMARK 465 THR B 318 REMARK 465 GLY B 319 REMARK 465 MET B 320 REMARK 465 ARG B 321 REMARK 465 ASN B 322 REMARK 465 VAL B 323 REMARK 465 PRO B 324 REMARK 465 GLU B 325 REMARK 465 LYS B 326 REMARK 465 GLN B 327 REMARK 465 THR B 328 REMARK 465 ARG B 329 REMARK 465 GLY B 330 REMARK 465 ILE B 331 REMARK 465 PHE B 332 REMARK 465 GLY B 333 REMARK 465 ALA B 334 REMARK 465 ILE B 335 REMARK 465 ALA B 336 REMARK 465 GLY B 337 REMARK 465 PHE B 338 REMARK 465 ILE B 339 REMARK 465 GLU B 340 REMARK 465 ASN B 341 REMARK 465 GLY B 342 REMARK 465 TRP B 343 REMARK 465 GLU B 344 REMARK 465 GLY B 345 REMARK 465 MET B 346 REMARK 465 VAL B 347 REMARK 465 ASP B 348 REMARK 465 GLY B 349 REMARK 465 TRP B 350 REMARK 465 TYR B 351 REMARK 465 GLY B 352 REMARK 465 PHE B 353 REMARK 465 ARG B 354 REMARK 465 TRP B 355 REMARK 465 GLN B 356 REMARK 465 ASN B 357 REMARK 465 SER B 358 REMARK 465 GLU B 359 REMARK 465 GLY B 360 REMARK 465 ARG B 361 REMARK 465 ASN B 445 REMARK 465 LYS B 446 REMARK 465 LEU B 447 REMARK 465 PHE B 448 REMARK 465 GLU B 449 REMARK 465 LYS B 450 REMARK 465 THR B 451 REMARK 465 LYS B 452 REMARK 465 LYS B 453 REMARK 465 GLN B 454 REMARK 465 LEU B 455 REMARK 465 ARG B 456 REMARK 465 GLU B 457 REMARK 465 ASN B 458 REMARK 465 ALA B 459 REMARK 465 GLU B 460 REMARK 465 ASP B 461 REMARK 465 MET B 462 REMARK 465 GLY B 463 REMARK 465 ASN B 464 REMARK 465 GLY B 465 REMARK 465 CYS B 466 REMARK 465 PHE B 467 REMARK 465 LYS B 468 REMARK 465 ILE B 469 REMARK 465 TYR B 470 REMARK 465 HIS B 471 REMARK 465 LYS B 472 REMARK 465 CYS B 473 REMARK 465 ASP B 474 REMARK 465 ASN B 475 REMARK 465 ALA B 476 REMARK 465 CYS B 477 REMARK 465 ILE B 478 REMARK 465 GLY B 479 REMARK 465 SER B 480 REMARK 465 ILE B 481 REMARK 465 ARG B 482 REMARK 465 ASN B 483 REMARK 465 GLU B 484 REMARK 465 THR B 485 REMARK 465 TYR B 486 REMARK 465 ASP B 487 REMARK 465 HIS B 488 REMARK 465 ASN B 489 REMARK 465 VAL B 490 REMARK 465 TYR B 491 REMARK 465 ARG B 492 REMARK 465 ASP B 493 REMARK 465 GLU B 494 REMARK 465 ALA B 495 REMARK 465 LEU B 496 REMARK 465 ASN B 497 REMARK 465 ASN B 498 REMARK 465 ARG B 499 REMARK 465 PHE B 500 REMARK 465 GLN B 501 REMARK 465 ILE B 502 REMARK 465 LYS B 503 REMARK 465 GLY B 504 REMARK 465 ALA B 505 REMARK 465 GLY B 506 REMARK 465 SER B 507 REMARK 465 SER B 508 REMARK 465 LEU B 509 REMARK 465 GLU B 510 REMARK 465 VAL B 511 REMARK 465 LEU B 512 REMARK 465 PHE B 513 REMARK 465 GLN B 514 REMARK 465 GLN C 1 REMARK 465 LYS C 2 REMARK 465 ILE C 3 REMARK 465 PRO C 4 REMARK 465 GLY C 5 REMARK 465 ASN C 6 REMARK 465 ASP C 7 REMARK 465 ASN C 8 REMARK 465 SER C 9 REMARK 465 THR C 10 REMARK 465 ALA C 11 REMARK 465 THR C 12 REMARK 465 LEU C 13 REMARK 465 CYS C 14 REMARK 465 LEU C 15 REMARK 465 GLU C 325 REMARK 465 LYS C 326 REMARK 465 GLN C 327 REMARK 465 THR C 328 REMARK 465 ARG C 329 REMARK 465 GLY C 330 REMARK 465 ILE C 331 REMARK 465 PHE C 332 REMARK 465 GLY C 333 REMARK 465 ALA C 334 REMARK 465 ILE C 335 REMARK 465 ALA C 336 REMARK 465 GLY C 337 REMARK 465 PHE C 338 REMARK 465 ILE C 339 REMARK 465 GLU C 340 REMARK 465 ASN C 341 REMARK 465 GLY C 342 REMARK 465 TRP C 343 REMARK 465 GLU C 344 REMARK 465 GLY C 345 REMARK 465 MET C 346 REMARK 465 VAL C 347 REMARK 465 ASP C 348 REMARK 465 GLY C 349 REMARK 465 TRP C 350 REMARK 465 TYR C 351 REMARK 465 GLY C 352 REMARK 465 PHE C 353 REMARK 465 ARG C 354 REMARK 465 TRP C 355 REMARK 465 GLN C 356 REMARK 465 ASN C 357 REMARK 465 SER C 358 REMARK 465 GLU C 359 REMARK 465 GLY C 360 REMARK 465 ARG C 361 REMARK 465 GLY C 362 REMARK 465 GLN C 363 REMARK 465 ASN C 445 REMARK 465 LYS C 446 REMARK 465 LEU C 447 REMARK 465 PHE C 448 REMARK 465 GLU C 449 REMARK 465 LYS C 450 REMARK 465 THR C 451 REMARK 465 LYS C 452 REMARK 465 LYS C 453 REMARK 465 GLN C 454 REMARK 465 LEU C 455 REMARK 465 ARG C 456 REMARK 465 GLU C 457 REMARK 465 ASN C 458 REMARK 465 ALA C 459 REMARK 465 GLU C 460 REMARK 465 ASP C 461 REMARK 465 MET C 462 REMARK 465 GLY C 463 REMARK 465 ASN C 464 REMARK 465 GLY C 465 REMARK 465 CYS C 466 REMARK 465 PHE C 467 REMARK 465 LYS C 468 REMARK 465 ILE C 469 REMARK 465 TYR C 470 REMARK 465 HIS C 471 REMARK 465 LYS C 472 REMARK 465 CYS C 473 REMARK 465 ASP C 474 REMARK 465 ASN C 475 REMARK 465 ALA C 476 REMARK 465 CYS C 477 REMARK 465 ILE C 478 REMARK 465 GLY C 479 REMARK 465 SER C 480 REMARK 465 ILE C 481 REMARK 465 ARG C 482 REMARK 465 ASN C 483 REMARK 465 GLU C 484 REMARK 465 THR C 485 REMARK 465 TYR C 486 REMARK 465 ASP C 487 REMARK 465 HIS C 488 REMARK 465 ASN C 489 REMARK 465 VAL C 490 REMARK 465 TYR C 491 REMARK 465 ARG C 492 REMARK 465 ASP C 493 REMARK 465 GLU C 494 REMARK 465 ALA C 495 REMARK 465 LEU C 496 REMARK 465 ASN C 497 REMARK 465 ASN C 498 REMARK 465 ARG C 499 REMARK 465 PHE C 500 REMARK 465 GLN C 501 REMARK 465 ILE C 502 REMARK 465 LYS C 503 REMARK 465 GLY C 504 REMARK 465 ALA C 505 REMARK 465 GLY C 506 REMARK 465 SER C 507 REMARK 465 SER C 508 REMARK 465 LEU C 509 REMARK 465 GLU C 510 REMARK 465 VAL C 511 REMARK 465 LEU C 512 REMARK 465 PHE C 513 REMARK 465 GLN C 514 REMARK 465 ALA D 126 REMARK 465 SER D 127 REMARK 465 THR D 128 REMARK 465 LYS D 129 REMARK 465 GLY D 130 REMARK 465 PRO D 131 REMARK 465 SER D 132 REMARK 465 VAL D 133 REMARK 465 PHE D 134 REMARK 465 PRO D 135 REMARK 465 LEU D 136 REMARK 465 ALA D 137 REMARK 465 PRO D 138 REMARK 465 SER D 139 REMARK 465 SER D 140 REMARK 465 LYS D 141 REMARK 465 SER D 142 REMARK 465 THR D 143 REMARK 465 SER D 144 REMARK 465 GLY D 145 REMARK 465 GLY D 146 REMARK 465 THR D 147 REMARK 465 ALA D 148 REMARK 465 ALA D 149 REMARK 465 LEU D 150 REMARK 465 GLY D 151 REMARK 465 CYS D 152 REMARK 465 LEU D 153 REMARK 465 VAL D 154 REMARK 465 LYS D 155 REMARK 465 ASP D 156 REMARK 465 TYR D 157 REMARK 465 PHE D 158 REMARK 465 PRO D 159 REMARK 465 GLU D 160 REMARK 465 PRO D 161 REMARK 465 VAL D 162 REMARK 465 THR D 163 REMARK 465 VAL D 164 REMARK 465 SER D 165 REMARK 465 TRP D 166 REMARK 465 ASN D 167 REMARK 465 SER D 168 REMARK 465 GLY D 169 REMARK 465 ALA D 170 REMARK 465 LEU D 171 REMARK 465 THR D 172 REMARK 465 SER D 173 REMARK 465 GLY D 174 REMARK 465 VAL D 175 REMARK 465 HIS D 176 REMARK 465 THR D 177 REMARK 465 PHE D 178 REMARK 465 PRO D 179 REMARK 465 ALA D 180 REMARK 465 VAL D 181 REMARK 465 LEU D 182 REMARK 465 GLN D 183 REMARK 465 SER D 184 REMARK 465 SER D 185 REMARK 465 GLY D 186 REMARK 465 LEU D 187 REMARK 465 TYR D 188 REMARK 465 SER D 189 REMARK 465 LEU D 190 REMARK 465 SER D 191 REMARK 465 SER D 192 REMARK 465 VAL D 193 REMARK 465 VAL D 194 REMARK 465 THR D 195 REMARK 465 VAL D 196 REMARK 465 PRO D 197 REMARK 465 SER D 198 REMARK 465 SER D 199 REMARK 465 SER D 200 REMARK 465 LEU D 201 REMARK 465 GLY D 202 REMARK 465 THR D 203 REMARK 465 GLN D 204 REMARK 465 THR D 205 REMARK 465 TYR D 206 REMARK 465 ILE D 207 REMARK 465 CYS D 208 REMARK 465 ASN D 209 REMARK 465 VAL D 210 REMARK 465 ASN D 211 REMARK 465 HIS D 212 REMARK 465 LYS D 213 REMARK 465 PRO D 214 REMARK 465 SER D 215 REMARK 465 ASN D 216 REMARK 465 THR D 217 REMARK 465 LYS D 218 REMARK 465 VAL D 219 REMARK 465 ASP D 220 REMARK 465 LYS D 221 REMARK 465 ARG D 222 REMARK 465 VAL D 223 REMARK 465 GLU D 224 REMARK 465 PRO D 225 REMARK 465 LYS D 226 REMARK 465 SER D 227 REMARK 465 CYS D 228 REMARK 465 ASP D 229 REMARK 465 LYS D 230 REMARK 465 GLY D 231 REMARK 465 SER D 232 REMARK 465 SER D 233 REMARK 465 LEU D 234 REMARK 465 GLU D 235 REMARK 465 VAL D 236 REMARK 465 LEU D 237 REMARK 465 PHE D 238 REMARK 465 GLN D 239 REMARK 465 GLU E 1 REMARK 465 ALA E 126 REMARK 465 SER E 127 REMARK 465 THR E 128 REMARK 465 LYS E 129 REMARK 465 GLY E 130 REMARK 465 PRO E 131 REMARK 465 SER E 132 REMARK 465 VAL E 133 REMARK 465 PHE E 134 REMARK 465 PRO E 135 REMARK 465 LEU E 136 REMARK 465 ALA E 137 REMARK 465 PRO E 138 REMARK 465 SER E 139 REMARK 465 SER E 140 REMARK 465 LYS E 141 REMARK 465 SER E 142 REMARK 465 THR E 143 REMARK 465 SER E 144 REMARK 465 GLY E 145 REMARK 465 GLY E 146 REMARK 465 THR E 147 REMARK 465 ALA E 148 REMARK 465 ALA E 149 REMARK 465 LEU E 150 REMARK 465 GLY E 151 REMARK 465 CYS E 152 REMARK 465 LEU E 153 REMARK 465 VAL E 154 REMARK 465 LYS E 155 REMARK 465 ASP E 156 REMARK 465 TYR E 157 REMARK 465 PHE E 158 REMARK 465 PRO E 159 REMARK 465 GLU E 160 REMARK 465 PRO E 161 REMARK 465 VAL E 162 REMARK 465 THR E 163 REMARK 465 VAL E 164 REMARK 465 SER E 165 REMARK 465 TRP E 166 REMARK 465 ASN E 167 REMARK 465 SER E 168 REMARK 465 GLY E 169 REMARK 465 ALA E 170 REMARK 465 LEU E 171 REMARK 465 THR E 172 REMARK 465 SER E 173 REMARK 465 GLY E 174 REMARK 465 VAL E 175 REMARK 465 HIS E 176 REMARK 465 THR E 177 REMARK 465 PHE E 178 REMARK 465 PRO E 179 REMARK 465 ALA E 180 REMARK 465 VAL E 181 REMARK 465 LEU E 182 REMARK 465 GLN E 183 REMARK 465 SER E 184 REMARK 465 SER E 185 REMARK 465 GLY E 186 REMARK 465 LEU E 187 REMARK 465 TYR E 188 REMARK 465 SER E 189 REMARK 465 LEU E 190 REMARK 465 SER E 191 REMARK 465 SER E 192 REMARK 465 VAL E 193 REMARK 465 VAL E 194 REMARK 465 THR E 195 REMARK 465 VAL E 196 REMARK 465 PRO E 197 REMARK 465 SER E 198 REMARK 465 SER E 199 REMARK 465 SER E 200 REMARK 465 LEU E 201 REMARK 465 GLY E 202 REMARK 465 THR E 203 REMARK 465 GLN E 204 REMARK 465 THR E 205 REMARK 465 TYR E 206 REMARK 465 ILE E 207 REMARK 465 CYS E 208 REMARK 465 ASN E 209 REMARK 465 VAL E 210 REMARK 465 ASN E 211 REMARK 465 HIS E 212 REMARK 465 LYS E 213 REMARK 465 PRO E 214 REMARK 465 SER E 215 REMARK 465 ASN E 216 REMARK 465 THR E 217 REMARK 465 LYS E 218 REMARK 465 VAL E 219 REMARK 465 ASP E 220 REMARK 465 LYS E 221 REMARK 465 ARG E 222 REMARK 465 VAL E 223 REMARK 465 GLU E 224 REMARK 465 PRO E 225 REMARK 465 LYS E 226 REMARK 465 SER E 227 REMARK 465 CYS E 228 REMARK 465 ASP E 229 REMARK 465 LYS E 230 REMARK 465 GLY E 231 REMARK 465 SER E 232 REMARK 465 SER E 233 REMARK 465 LEU E 234 REMARK 465 GLU E 235 REMARK 465 VAL E 236 REMARK 465 LEU E 237 REMARK 465 PHE E 238 REMARK 465 GLN E 239 REMARK 465 ALA F 126 REMARK 465 SER F 127 REMARK 465 THR F 128 REMARK 465 LYS F 129 REMARK 465 GLY F 130 REMARK 465 PRO F 131 REMARK 465 SER F 132 REMARK 465 VAL F 133 REMARK 465 PHE F 134 REMARK 465 PRO F 135 REMARK 465 LEU F 136 REMARK 465 ALA F 137 REMARK 465 PRO F 138 REMARK 465 SER F 139 REMARK 465 SER F 140 REMARK 465 LYS F 141 REMARK 465 SER F 142 REMARK 465 THR F 143 REMARK 465 SER F 144 REMARK 465 GLY F 145 REMARK 465 GLY F 146 REMARK 465 THR F 147 REMARK 465 ALA F 148 REMARK 465 ALA F 149 REMARK 465 LEU F 150 REMARK 465 GLY F 151 REMARK 465 CYS F 152 REMARK 465 LEU F 153 REMARK 465 VAL F 154 REMARK 465 LYS F 155 REMARK 465 ASP F 156 REMARK 465 TYR F 157 REMARK 465 PHE F 158 REMARK 465 PRO F 159 REMARK 465 GLU F 160 REMARK 465 PRO F 161 REMARK 465 VAL F 162 REMARK 465 THR F 163 REMARK 465 VAL F 164 REMARK 465 SER F 165 REMARK 465 TRP F 166 REMARK 465 ASN F 167 REMARK 465 SER F 168 REMARK 465 GLY F 169 REMARK 465 ALA F 170 REMARK 465 LEU F 171 REMARK 465 THR F 172 REMARK 465 SER F 173 REMARK 465 GLY F 174 REMARK 465 VAL F 175 REMARK 465 HIS F 176 REMARK 465 THR F 177 REMARK 465 PHE F 178 REMARK 465 PRO F 179 REMARK 465 ALA F 180 REMARK 465 VAL F 181 REMARK 465 LEU F 182 REMARK 465 GLN F 183 REMARK 465 SER F 184 REMARK 465 SER F 185 REMARK 465 GLY F 186 REMARK 465 LEU F 187 REMARK 465 TYR F 188 REMARK 465 SER F 189 REMARK 465 LEU F 190 REMARK 465 SER F 191 REMARK 465 SER F 192 REMARK 465 VAL F 193 REMARK 465 VAL F 194 REMARK 465 THR F 195 REMARK 465 VAL F 196 REMARK 465 PRO F 197 REMARK 465 SER F 198 REMARK 465 SER F 199 REMARK 465 SER F 200 REMARK 465 LEU F 201 REMARK 465 GLY F 202 REMARK 465 THR F 203 REMARK 465 GLN F 204 REMARK 465 THR F 205 REMARK 465 TYR F 206 REMARK 465 ILE F 207 REMARK 465 CYS F 208 REMARK 465 ASN F 209 REMARK 465 VAL F 210 REMARK 465 ASN F 211 REMARK 465 HIS F 212 REMARK 465 LYS F 213 REMARK 465 PRO F 214 REMARK 465 SER F 215 REMARK 465 ASN F 216 REMARK 465 THR F 217 REMARK 465 LYS F 218 REMARK 465 VAL F 219 REMARK 465 ASP F 220 REMARK 465 LYS F 221 REMARK 465 ARG F 222 REMARK 465 VAL F 223 REMARK 465 GLU F 224 REMARK 465 PRO F 225 REMARK 465 LYS F 226 REMARK 465 SER F 227 REMARK 465 CYS F 228 REMARK 465 ASP F 229 REMARK 465 LYS F 230 REMARK 465 GLY F 231 REMARK 465 SER F 232 REMARK 465 SER F 233 REMARK 465 LEU F 234 REMARK 465 GLU F 235 REMARK 465 VAL F 236 REMARK 465 LEU F 237 REMARK 465 PHE F 238 REMARK 465 GLN F 239 REMARK 465 ARG G 108 REMARK 465 THR G 109 REMARK 465 VAL G 110 REMARK 465 ALA G 111 REMARK 465 ALA G 112 REMARK 465 PRO G 113 REMARK 465 SER G 114 REMARK 465 VAL G 115 REMARK 465 PHE G 116 REMARK 465 ILE G 117 REMARK 465 PHE G 118 REMARK 465 PRO G 119 REMARK 465 PRO G 120 REMARK 465 SER G 121 REMARK 465 ASP G 122 REMARK 465 GLU G 123 REMARK 465 GLN G 124 REMARK 465 LEU G 125 REMARK 465 LYS G 126 REMARK 465 SER G 127 REMARK 465 GLY G 128 REMARK 465 THR G 129 REMARK 465 ALA G 130 REMARK 465 SER G 131 REMARK 465 VAL G 132 REMARK 465 VAL G 133 REMARK 465 CYS G 134 REMARK 465 LEU G 135 REMARK 465 LEU G 136 REMARK 465 ASN G 137 REMARK 465 ASN G 138 REMARK 465 PHE G 139 REMARK 465 TYR G 140 REMARK 465 PRO G 141 REMARK 465 ARG G 142 REMARK 465 GLU G 143 REMARK 465 ALA G 144 REMARK 465 LYS G 145 REMARK 465 VAL G 146 REMARK 465 GLN G 147 REMARK 465 TRP G 148 REMARK 465 LYS G 149 REMARK 465 VAL G 150 REMARK 465 ASP G 151 REMARK 465 ASN G 152 REMARK 465 ALA G 153 REMARK 465 LEU G 154 REMARK 465 GLN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ASN G 158 REMARK 465 SER G 159 REMARK 465 GLN G 160 REMARK 465 GLU G 161 REMARK 465 SER G 162 REMARK 465 VAL G 163 REMARK 465 THR G 164 REMARK 465 GLU G 165 REMARK 465 GLN G 166 REMARK 465 ASP G 167 REMARK 465 SER G 168 REMARK 465 LYS G 169 REMARK 465 ASP G 170 REMARK 465 SER G 171 REMARK 465 THR G 172 REMARK 465 TYR G 173 REMARK 465 SER G 174 REMARK 465 LEU G 175 REMARK 465 SER G 176 REMARK 465 SER G 177 REMARK 465 THR G 178 REMARK 465 LEU G 179 REMARK 465 THR G 180 REMARK 465 LEU G 181 REMARK 465 SER G 182 REMARK 465 LYS G 183 REMARK 465 ALA G 184 REMARK 465 ASP G 185 REMARK 465 TYR G 186 REMARK 465 GLU G 187 REMARK 465 LYS G 188 REMARK 465 HIS G 189 REMARK 465 LYS G 190 REMARK 465 VAL G 191 REMARK 465 TYR G 192 REMARK 465 ALA G 193 REMARK 465 CYS G 194 REMARK 465 GLU G 195 REMARK 465 VAL G 196 REMARK 465 THR G 197 REMARK 465 HIS G 198 REMARK 465 GLN G 199 REMARK 465 GLY G 200 REMARK 465 LEU G 201 REMARK 465 SER G 202 REMARK 465 SER G 203 REMARK 465 PRO G 204 REMARK 465 VAL G 205 REMARK 465 THR G 206 REMARK 465 LYS G 207 REMARK 465 SER G 208 REMARK 465 PHE G 209 REMARK 465 ASN G 210 REMARK 465 ARG G 211 REMARK 465 GLY G 212 REMARK 465 GLU G 213 REMARK 465 CYS G 214 REMARK 465 ARG H 108 REMARK 465 THR H 109 REMARK 465 VAL H 110 REMARK 465 ALA H 111 REMARK 465 ALA H 112 REMARK 465 PRO H 113 REMARK 465 SER H 114 REMARK 465 VAL H 115 REMARK 465 PHE H 116 REMARK 465 ILE H 117 REMARK 465 PHE H 118 REMARK 465 PRO H 119 REMARK 465 PRO H 120 REMARK 465 SER H 121 REMARK 465 ASP H 122 REMARK 465 GLU H 123 REMARK 465 GLN H 124 REMARK 465 LEU H 125 REMARK 465 LYS H 126 REMARK 465 SER H 127 REMARK 465 GLY H 128 REMARK 465 THR H 129 REMARK 465 ALA H 130 REMARK 465 SER H 131 REMARK 465 VAL H 132 REMARK 465 VAL H 133 REMARK 465 CYS H 134 REMARK 465 LEU H 135 REMARK 465 LEU H 136 REMARK 465 ASN H 137 REMARK 465 ASN H 138 REMARK 465 PHE H 139 REMARK 465 TYR H 140 REMARK 465 PRO H 141 REMARK 465 ARG H 142 REMARK 465 GLU H 143 REMARK 465 ALA H 144 REMARK 465 LYS H 145 REMARK 465 VAL H 146 REMARK 465 GLN H 147 REMARK 465 TRP H 148 REMARK 465 LYS H 149 REMARK 465 VAL H 150 REMARK 465 ASP H 151 REMARK 465 ASN H 152 REMARK 465 ALA H 153 REMARK 465 LEU H 154 REMARK 465 GLN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ASN H 158 REMARK 465 SER H 159 REMARK 465 GLN H 160 REMARK 465 GLU H 161 REMARK 465 SER H 162 REMARK 465 VAL H 163 REMARK 465 THR H 164 REMARK 465 GLU H 165 REMARK 465 GLN H 166 REMARK 465 ASP H 167 REMARK 465 SER H 168 REMARK 465 LYS H 169 REMARK 465 ASP H 170 REMARK 465 SER H 171 REMARK 465 THR H 172 REMARK 465 TYR H 173 REMARK 465 SER H 174 REMARK 465 LEU H 175 REMARK 465 SER H 176 REMARK 465 SER H 177 REMARK 465 THR H 178 REMARK 465 LEU H 179 REMARK 465 THR H 180 REMARK 465 LEU H 181 REMARK 465 SER H 182 REMARK 465 LYS H 183 REMARK 465 ALA H 184 REMARK 465 ASP H 185 REMARK 465 TYR H 186 REMARK 465 GLU H 187 REMARK 465 LYS H 188 REMARK 465 HIS H 189 REMARK 465 LYS H 190 REMARK 465 VAL H 191 REMARK 465 TYR H 192 REMARK 465 ALA H 193 REMARK 465 CYS H 194 REMARK 465 GLU H 195 REMARK 465 VAL H 196 REMARK 465 THR H 197 REMARK 465 HIS H 198 REMARK 465 GLN H 199 REMARK 465 GLY H 200 REMARK 465 LEU H 201 REMARK 465 SER H 202 REMARK 465 SER H 203 REMARK 465 PRO H 204 REMARK 465 VAL H 205 REMARK 465 THR H 206 REMARK 465 LYS H 207 REMARK 465 SER H 208 REMARK 465 PHE H 209 REMARK 465 ASN H 210 REMARK 465 ARG H 211 REMARK 465 GLY H 212 REMARK 465 GLU H 213 REMARK 465 CYS H 214 REMARK 465 ARG I 108 REMARK 465 THR I 109 REMARK 465 VAL I 110 REMARK 465 ALA I 111 REMARK 465 ALA I 112 REMARK 465 PRO I 113 REMARK 465 SER I 114 REMARK 465 VAL I 115 REMARK 465 PHE I 116 REMARK 465 ILE I 117 REMARK 465 PHE I 118 REMARK 465 PRO I 119 REMARK 465 PRO I 120 REMARK 465 SER I 121 REMARK 465 ASP I 122 REMARK 465 GLU I 123 REMARK 465 GLN I 124 REMARK 465 LEU I 125 REMARK 465 LYS I 126 REMARK 465 SER I 127 REMARK 465 GLY I 128 REMARK 465 THR I 129 REMARK 465 ALA I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 VAL I 133 REMARK 465 CYS I 134 REMARK 465 LEU I 135 REMARK 465 LEU I 136 REMARK 465 ASN I 137 REMARK 465 ASN I 138 REMARK 465 PHE I 139 REMARK 465 TYR I 140 REMARK 465 PRO I 141 REMARK 465 ARG I 142 REMARK 465 GLU I 143 REMARK 465 ALA I 144 REMARK 465 LYS I 145 REMARK 465 VAL I 146 REMARK 465 GLN I 147 REMARK 465 TRP I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 ASP I 151 REMARK 465 ASN I 152 REMARK 465 ALA I 153 REMARK 465 LEU I 154 REMARK 465 GLN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLN I 160 REMARK 465 GLU I 161 REMARK 465 SER I 162 REMARK 465 VAL I 163 REMARK 465 THR I 164 REMARK 465 GLU I 165 REMARK 465 GLN I 166 REMARK 465 ASP I 167 REMARK 465 SER I 168 REMARK 465 LYS I 169 REMARK 465 ASP I 170 REMARK 465 SER I 171 REMARK 465 THR I 172 REMARK 465 TYR I 173 REMARK 465 SER I 174 REMARK 465 LEU I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 THR I 178 REMARK 465 LEU I 179 REMARK 465 THR I 180 REMARK 465 LEU I 181 REMARK 465 SER I 182 REMARK 465 LYS I 183 REMARK 465 ALA I 184 REMARK 465 ASP I 185 REMARK 465 TYR I 186 REMARK 465 GLU I 187 REMARK 465 LYS I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 VAL I 191 REMARK 465 TYR I 192 REMARK 465 ALA I 193 REMARK 465 CYS I 194 REMARK 465 GLU I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLN I 199 REMARK 465 GLY I 200 REMARK 465 LEU I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 PRO I 204 REMARK 465 VAL I 205 REMARK 465 THR I 206 REMARK 465 LYS I 207 REMARK 465 SER I 208 REMARK 465 PHE I 209 REMARK 465 ASN I 210 REMARK 465 ARG I 211 REMARK 465 GLY I 212 REMARK 465 GLU I 213 REMARK 465 CYS I 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG SER C 219 O7 NAG L 1 2.13 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 THR A 206 -168.85 -128.44 REMARK 500 ASP A 271 66.10 -101.79 REMARK 500 THR B 37 -61.31 -92.09 REMARK 500 ASN B 38 -61.42 -102.18 REMARK 500 ALA B 39 70.85 59.18 REMARK 500 THR B 206 -169.65 -122.78 REMARK 500 ASP B 271 58.19 -99.09 REMARK 500 LYS B 310 31.15 -94.76 REMARK 500 THR C 206 -168.84 -126.34 REMARK 500 SER C 265 148.89 -173.35 REMARK 500 LYS C 310 35.05 -99.34 REMARK 500 ASN F 54 -4.64 67.81 REMARK 500 LEU G 47 -60.93 -94.94 REMARK 500 ALA G 51 -6.57 73.01 REMARK 500 ASP G 82 34.22 -98.63 REMARK 500 ALA H 51 -6.47 73.11 REMARK 500 SER H 52 -1.86 -143.65 REMARK 500 MET H 94 64.25 -119.46 REMARK 500 ALA I 51 -8.48 72.75 REMARK 500 SER I 52 -2.01 -140.11 REMARK 500 GLN I 100 -169.26 -77.76 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-44452 RELATED DB: EMDB REMARK 900 INFLUENZA A VIRUS HEMAGGLUTININ H3/DARWIN/6/2021 IN COMPLEX WITH REMARK 900 FAB ADI-85647 DBREF1 9BDG A 1 505 UNP A0A8F5JT24_9INFA DBREF2 9BDG A A0A8F5JT24 17 521 DBREF1 9BDG B 1 505 UNP A0A8F5JT24_9INFA DBREF2 9BDG B A0A8F5JT24 17 521 DBREF1 9BDG C 1 505 UNP A0A8F5JT24_9INFA DBREF2 9BDG C A0A8F5JT24 17 521 DBREF 9BDG D 1 239 PDB 9BDG 9BDG 1 239 DBREF 9BDG E 1 239 PDB 9BDG 9BDG 1 239 DBREF 9BDG F 1 239 PDB 9BDG 9BDG 1 239 DBREF 9BDG G 1 214 UNP Q7Z3Y4 Q7Z3Y4_HUMAN 23 236 DBREF 9BDG H 1 214 UNP Q7Z3Y4 Q7Z3Y4_HUMAN 23 236 DBREF 9BDG I 1 214 UNP Q7Z3Y4 Q7Z3Y4_HUMAN 23 236 SEQADV 9BDG ASN A 31 UNP A0A8F5JT2 ASP 47 CONFLICT SEQADV 9BDG GLY A 53 UNP A0A8F5JT2 ASP 69 CONFLICT SEQADV 9BDG TRP A 355 UNP A0A8F5JT2 HIS 371 CONFLICT SEQADV 9BDG ILE A 380 UNP A0A8F5JT2 LYS 396 CONFLICT SEQADV 9BDG ILE A 432 UNP A0A8F5JT2 GLU 448 CONFLICT SEQADV 9BDG ALA A 505 UNP A0A8F5JT2 VAL 521 CONFLICT SEQADV 9BDG GLY A 506 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG SER A 507 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG SER A 508 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG LEU A 509 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG GLU A 510 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG VAL A 511 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG LEU A 512 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG PHE A 513 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG GLN A 514 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG ASN B 31 UNP A0A8F5JT2 ASP 47 CONFLICT SEQADV 9BDG GLY B 53 UNP A0A8F5JT2 ASP 69 CONFLICT SEQADV 9BDG TRP B 355 UNP A0A8F5JT2 HIS 371 CONFLICT SEQADV 9BDG ILE B 380 UNP A0A8F5JT2 LYS 396 CONFLICT SEQADV 9BDG ILE B 432 UNP A0A8F5JT2 GLU 448 CONFLICT SEQADV 9BDG ALA B 505 UNP A0A8F5JT2 VAL 521 CONFLICT SEQADV 9BDG GLY B 506 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG SER B 507 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG SER B 508 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG LEU B 509 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG GLU B 510 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG VAL B 511 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG LEU B 512 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG PHE B 513 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG GLN B 514 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG ASN C 31 UNP A0A8F5JT2 ASP 47 CONFLICT SEQADV 9BDG GLY C 53 UNP A0A8F5JT2 ASP 69 CONFLICT SEQADV 9BDG TRP C 355 UNP A0A8F5JT2 HIS 371 CONFLICT SEQADV 9BDG ILE C 380 UNP A0A8F5JT2 LYS 396 CONFLICT SEQADV 9BDG ILE C 432 UNP A0A8F5JT2 GLU 448 CONFLICT SEQADV 9BDG ALA C 505 UNP A0A8F5JT2 VAL 521 CONFLICT SEQADV 9BDG GLY C 506 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG SER C 507 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG SER C 508 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG LEU C 509 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG GLU C 510 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG VAL C 511 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG LEU C 512 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG PHE C 513 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG GLN C 514 UNP A0A8F5JT2 EXPRESSION TAG SEQADV 9BDG VAL G 3 UNP Q7Z3Y4 GLN 25 CONFLICT SEQADV 9BDG PRO G 9 UNP Q7Z3Y4 SER 31 CONFLICT SEQADV 9BDG THR G 14 UNP Q7Z3Y4 SER 36 CONFLICT SEQADV 9BDG ARG G 18 UNP Q7Z3Y4 THR 40 CONFLICT SEQADV 9BDG SER G 28 UNP Q7Z3Y4 ASP 50 CONFLICT SEQADV 9BDG ASN G 34 UNP Q7Z3Y4 ALA 56 CONFLICT SEQADV 9BDG TYR G 36 UNP Q7Z3Y4 PHE 58 CONFLICT SEQADV 9BDG LEU G 46 UNP Q7Z3Y4 SER 68 CONFLICT SEQADV 9BDG SER G 49 UNP Q7Z3Y4 TYR 71 CONFLICT SEQADV 9BDG LEU G 56 UNP Q7Z3Y4 SER 78 CONFLICT SEQADV 9BDG PRO G 59 UNP Q7Z3Y4 GLN 81 CONFLICT SEQADV 9BDG ARG G 61 UNP Q7Z3Y4 LYS 83 CONFLICT SEQADV 9BDG GLU G 66 UNP Q7Z3Y4 GLY 88 CONFLICT SEQADV 9BDG CYS G 83 UNP Q7Z3Y4 PHE 105 CONFLICT SEQADV 9BDG GLY G 91 UNP Q7Z3Y4 TYR 113 CONFLICT SEQADV 9BDG TYR G 92 UNP Q7Z3Y4 LYS 114 CONFLICT SEQADV 9BDG ILE G 93 UNP Q7Z3Y4 SER 115 CONFLICT SEQADV 9BDG MET G 94 UNP Q7Z3Y4 TYR 116 CONFLICT SEQADV 9BDG GLY G 96 UNP Q7Z3Y4 VAL 118 CONFLICT SEQADV 9BDG VAL G 104 UNP Q7Z3Y4 LEU 126 CONFLICT SEQADV 9BDG ASP G 105 UNP Q7Z3Y4 GLU 127 CONFLICT SEQADV 9BDG VAL H 3 UNP Q7Z3Y4 GLN 25 CONFLICT SEQADV 9BDG PRO H 9 UNP Q7Z3Y4 SER 31 CONFLICT SEQADV 9BDG THR H 14 UNP Q7Z3Y4 SER 36 CONFLICT SEQADV 9BDG ARG H 18 UNP Q7Z3Y4 THR 40 CONFLICT SEQADV 9BDG SER H 28 UNP Q7Z3Y4 ASP 50 CONFLICT SEQADV 9BDG ASN H 34 UNP Q7Z3Y4 ALA 56 CONFLICT SEQADV 9BDG TYR H 36 UNP Q7Z3Y4 PHE 58 CONFLICT SEQADV 9BDG LEU H 46 UNP Q7Z3Y4 SER 68 CONFLICT SEQADV 9BDG SER H 49 UNP Q7Z3Y4 TYR 71 CONFLICT SEQADV 9BDG LEU H 56 UNP Q7Z3Y4 SER 78 CONFLICT SEQADV 9BDG PRO H 59 UNP Q7Z3Y4 GLN 81 CONFLICT SEQADV 9BDG ARG H 61 UNP Q7Z3Y4 LYS 83 CONFLICT SEQADV 9BDG GLU H 66 UNP Q7Z3Y4 GLY 88 CONFLICT SEQADV 9BDG CYS H 83 UNP Q7Z3Y4 PHE 105 CONFLICT SEQADV 9BDG GLY H 91 UNP Q7Z3Y4 TYR 113 CONFLICT SEQADV 9BDG TYR H 92 UNP Q7Z3Y4 LYS 114 CONFLICT SEQADV 9BDG ILE H 93 UNP Q7Z3Y4 SER 115 CONFLICT SEQADV 9BDG MET H 94 UNP Q7Z3Y4 TYR 116 CONFLICT SEQADV 9BDG GLY H 96 UNP Q7Z3Y4 VAL 118 CONFLICT SEQADV 9BDG VAL H 104 UNP Q7Z3Y4 LEU 126 CONFLICT SEQADV 9BDG ASP H 105 UNP Q7Z3Y4 GLU 127 CONFLICT SEQADV 9BDG VAL I 3 UNP Q7Z3Y4 GLN 25 CONFLICT SEQADV 9BDG PRO I 9 UNP Q7Z3Y4 SER 31 CONFLICT SEQADV 9BDG THR I 14 UNP Q7Z3Y4 SER 36 CONFLICT SEQADV 9BDG ARG I 18 UNP Q7Z3Y4 THR 40 CONFLICT SEQADV 9BDG SER I 28 UNP Q7Z3Y4 ASP 50 CONFLICT SEQADV 9BDG ASN I 34 UNP Q7Z3Y4 ALA 56 CONFLICT SEQADV 9BDG TYR I 36 UNP Q7Z3Y4 PHE 58 CONFLICT SEQADV 9BDG LEU I 46 UNP Q7Z3Y4 SER 68 CONFLICT SEQADV 9BDG SER I 49 UNP Q7Z3Y4 TYR 71 CONFLICT SEQADV 9BDG LEU I 56 UNP Q7Z3Y4 SER 78 CONFLICT SEQADV 9BDG PRO I 59 UNP Q7Z3Y4 GLN 81 CONFLICT SEQADV 9BDG ARG I 61 UNP Q7Z3Y4 LYS 83 CONFLICT SEQADV 9BDG GLU I 66 UNP Q7Z3Y4 GLY 88 CONFLICT SEQADV 9BDG CYS I 83 UNP Q7Z3Y4 PHE 105 CONFLICT SEQADV 9BDG GLY I 91 UNP Q7Z3Y4 TYR 113 CONFLICT SEQADV 9BDG TYR I 92 UNP Q7Z3Y4 LYS 114 CONFLICT SEQADV 9BDG ILE I 93 UNP Q7Z3Y4 SER 115 CONFLICT SEQADV 9BDG MET I 94 UNP Q7Z3Y4 TYR 116 CONFLICT SEQADV 9BDG GLY I 96 UNP Q7Z3Y4 VAL 118 CONFLICT SEQADV 9BDG VAL I 104 UNP Q7Z3Y4 LEU 126 CONFLICT SEQADV 9BDG ASP I 105 UNP Q7Z3Y4 GLU 127 CONFLICT SEQRES 1 A 514 GLN LYS ILE PRO GLY ASN ASP ASN SER THR ALA THR LEU SEQRES 2 A 514 CYS LEU GLY HIS HIS ALA VAL PRO ASN GLY THR ILE VAL SEQRES 3 A 514 LYS THR ILE THR ASN ASP ARG ILE GLU VAL THR ASN ALA SEQRES 4 A 514 THR GLU LEU VAL GLN ASN SER SER ILE GLY GLU ILE CYS SEQRES 5 A 514 GLY SER PRO HIS GLN ILE LEU ASP GLY GLY ASN CYS THR SEQRES 6 A 514 LEU ILE ASP ALA LEU LEU GLY ASP PRO GLN CYS ASP GLY SEQRES 7 A 514 PHE GLN ASN LYS GLU TRP ASP LEU PHE VAL GLU ARG SER SEQRES 8 A 514 ARG ALA ASN SER ASN CYS TYR PRO TYR ASP VAL PRO ASP SEQRES 9 A 514 TYR ALA SER LEU ARG SER LEU VAL ALA SER SER GLY THR SEQRES 10 A 514 LEU GLU PHE LYS ASN GLU SER PHE ASN TRP THR GLY VAL SEQRES 11 A 514 LYS GLN ASN GLY THR SER SER ALA CYS ILE ARG GLY SER SEQRES 12 A 514 SER SER SER PHE PHE SER ARG LEU ASN TRP LEU THR SER SEQRES 13 A 514 LEU ASN ASN ILE TYR PRO ALA GLN ASN VAL THR MET PRO SEQRES 14 A 514 ASN LYS GLU GLN PHE ASP LYS LEU TYR ILE TRP GLY VAL SEQRES 15 A 514 HIS HIS PRO ASP THR ASP LYS ASN GLN ILE SER LEU PHE SEQRES 16 A 514 ALA GLN SER SER GLY ARG ILE THR VAL SER THR LYS ARG SEQRES 17 A 514 SER GLN GLN ALA VAL ILE PRO ASN ILE GLY SER ARG PRO SEQRES 18 A 514 ARG ILE ARG ASP ILE PRO SER ARG ILE SER ILE TYR TRP SEQRES 19 A 514 THR ILE VAL LYS PRO GLY ASP ILE LEU LEU ILE ASN SER SEQRES 20 A 514 THR GLY ASN LEU ILE ALA PRO ARG GLY TYR PHE LYS ILE SEQRES 21 A 514 ARG SER GLY LYS SER SER ILE MET ARG SER ASP ALA PRO SEQRES 22 A 514 ILE GLY LYS CYS LYS SER GLU CYS ILE THR PRO ASN GLY SEQRES 23 A 514 SER ILE PRO ASN ASP LYS PRO PHE GLN ASN VAL ASN ARG SEQRES 24 A 514 ILE THR TYR GLY ALA CYS PRO ARG TYR VAL LYS GLN SER SEQRES 25 A 514 THR LEU LYS LEU ALA THR GLY MET ARG ASN VAL PRO GLU SEQRES 26 A 514 LYS GLN THR ARG GLY ILE PHE GLY ALA ILE ALA GLY PHE SEQRES 27 A 514 ILE GLU ASN GLY TRP GLU GLY MET VAL ASP GLY TRP TYR SEQRES 28 A 514 GLY PHE ARG TRP GLN ASN SER GLU GLY ARG GLY GLN ALA SEQRES 29 A 514 ALA ASP LEU LYS SER THR GLN ALA ALA ILE ASP GLN ILE SEQRES 30 A 514 ASN GLY ILE LEU ASN ARG LEU ILE GLY LYS THR ASN GLU SEQRES 31 A 514 LYS PHE HIS GLN ILE GLU LYS GLU PHE SER GLU VAL GLU SEQRES 32 A 514 GLY ARG VAL GLN ASP LEU GLU LYS TYR VAL GLU ASP THR SEQRES 33 A 514 LYS ILE ASP LEU TRP SER TYR ASN ALA GLU LEU LEU VAL SEQRES 34 A 514 ALA LEU ILE ASN GLN HIS THR ILE ASP LEU THR ASP SER SEQRES 35 A 514 GLU MET ASN LYS LEU PHE GLU LYS THR LYS LYS GLN LEU SEQRES 36 A 514 ARG GLU ASN ALA GLU ASP MET GLY ASN GLY CYS PHE LYS SEQRES 37 A 514 ILE TYR HIS LYS CYS ASP ASN ALA CYS ILE GLY SER ILE SEQRES 38 A 514 ARG ASN GLU THR TYR ASP HIS ASN VAL TYR ARG ASP GLU SEQRES 39 A 514 ALA LEU ASN ASN ARG PHE GLN ILE LYS GLY ALA GLY SER SEQRES 40 A 514 SER LEU GLU VAL LEU PHE GLN SEQRES 1 B 514 GLN LYS ILE PRO GLY ASN ASP ASN SER THR ALA THR LEU SEQRES 2 B 514 CYS LEU GLY HIS HIS ALA VAL PRO ASN GLY THR ILE VAL SEQRES 3 B 514 LYS THR ILE THR ASN ASP ARG ILE GLU VAL THR ASN ALA SEQRES 4 B 514 THR GLU LEU VAL GLN ASN SER SER ILE GLY GLU ILE CYS SEQRES 5 B 514 GLY SER PRO HIS GLN ILE LEU ASP GLY GLY ASN CYS THR SEQRES 6 B 514 LEU ILE ASP ALA LEU LEU GLY ASP PRO GLN CYS ASP GLY SEQRES 7 B 514 PHE GLN ASN LYS GLU TRP ASP LEU PHE VAL GLU ARG SER SEQRES 8 B 514 ARG ALA ASN SER ASN CYS TYR PRO TYR ASP VAL PRO ASP SEQRES 9 B 514 TYR ALA SER LEU ARG SER LEU VAL ALA SER SER GLY THR SEQRES 10 B 514 LEU GLU PHE LYS ASN GLU SER PHE ASN TRP THR GLY VAL SEQRES 11 B 514 LYS GLN ASN GLY THR SER SER ALA CYS ILE ARG GLY SER SEQRES 12 B 514 SER SER SER PHE PHE SER ARG LEU ASN TRP LEU THR SER SEQRES 13 B 514 LEU ASN ASN ILE TYR PRO ALA GLN ASN VAL THR MET PRO SEQRES 14 B 514 ASN LYS GLU GLN PHE ASP LYS LEU TYR ILE TRP GLY VAL SEQRES 15 B 514 HIS HIS PRO ASP THR ASP LYS ASN GLN ILE SER LEU PHE SEQRES 16 B 514 ALA GLN SER SER GLY ARG ILE THR VAL SER THR LYS ARG SEQRES 17 B 514 SER GLN GLN ALA VAL ILE PRO ASN ILE GLY SER ARG PRO SEQRES 18 B 514 ARG ILE ARG ASP ILE PRO SER ARG ILE SER ILE TYR TRP SEQRES 19 B 514 THR ILE VAL LYS PRO GLY ASP ILE LEU LEU ILE ASN SER SEQRES 20 B 514 THR GLY ASN LEU ILE ALA PRO ARG GLY TYR PHE LYS ILE SEQRES 21 B 514 ARG SER GLY LYS SER SER ILE MET ARG SER ASP ALA PRO SEQRES 22 B 514 ILE GLY LYS CYS LYS SER GLU CYS ILE THR PRO ASN GLY SEQRES 23 B 514 SER ILE PRO ASN ASP LYS PRO PHE GLN ASN VAL ASN ARG SEQRES 24 B 514 ILE THR TYR GLY ALA CYS PRO ARG TYR VAL LYS GLN SER SEQRES 25 B 514 THR LEU LYS LEU ALA THR GLY MET ARG ASN VAL PRO GLU SEQRES 26 B 514 LYS GLN THR ARG GLY ILE PHE GLY ALA ILE ALA GLY PHE SEQRES 27 B 514 ILE GLU ASN GLY TRP GLU GLY MET VAL ASP GLY TRP TYR SEQRES 28 B 514 GLY PHE ARG TRP GLN ASN SER GLU GLY ARG GLY GLN ALA SEQRES 29 B 514 ALA ASP LEU LYS SER THR GLN ALA ALA ILE ASP GLN ILE SEQRES 30 B 514 ASN GLY ILE LEU ASN ARG LEU ILE GLY LYS THR ASN GLU SEQRES 31 B 514 LYS PHE HIS GLN ILE GLU LYS GLU PHE SER GLU VAL GLU SEQRES 32 B 514 GLY ARG VAL GLN ASP LEU GLU LYS TYR VAL GLU ASP THR SEQRES 33 B 514 LYS ILE ASP LEU TRP SER TYR ASN ALA GLU LEU LEU VAL SEQRES 34 B 514 ALA LEU ILE ASN GLN HIS THR ILE ASP LEU THR ASP SER SEQRES 35 B 514 GLU MET ASN LYS LEU PHE GLU LYS THR LYS LYS GLN LEU SEQRES 36 B 514 ARG GLU ASN ALA GLU ASP MET GLY ASN GLY CYS PHE LYS SEQRES 37 B 514 ILE TYR HIS LYS CYS ASP ASN ALA CYS ILE GLY SER ILE SEQRES 38 B 514 ARG ASN GLU THR TYR ASP HIS ASN VAL TYR ARG ASP GLU SEQRES 39 B 514 ALA LEU ASN ASN ARG PHE GLN ILE LYS GLY ALA GLY SER SEQRES 40 B 514 SER LEU GLU VAL LEU PHE GLN SEQRES 1 C 514 GLN LYS ILE PRO GLY ASN ASP ASN SER THR ALA THR LEU SEQRES 2 C 514 CYS LEU GLY HIS HIS ALA VAL PRO ASN GLY THR ILE VAL SEQRES 3 C 514 LYS THR ILE THR ASN ASP ARG ILE GLU VAL THR ASN ALA SEQRES 4 C 514 THR GLU LEU VAL GLN ASN SER SER ILE GLY GLU ILE CYS SEQRES 5 C 514 GLY SER PRO HIS GLN ILE LEU ASP GLY GLY ASN CYS THR SEQRES 6 C 514 LEU ILE ASP ALA LEU LEU GLY ASP PRO GLN CYS ASP GLY SEQRES 7 C 514 PHE GLN ASN LYS GLU TRP ASP LEU PHE VAL GLU ARG SER SEQRES 8 C 514 ARG ALA ASN SER ASN CYS TYR PRO TYR ASP VAL PRO ASP SEQRES 9 C 514 TYR ALA SER LEU ARG SER LEU VAL ALA SER SER GLY THR SEQRES 10 C 514 LEU GLU PHE LYS ASN GLU SER PHE ASN TRP THR GLY VAL SEQRES 11 C 514 LYS GLN ASN GLY THR SER SER ALA CYS ILE ARG GLY SER SEQRES 12 C 514 SER SER SER PHE PHE SER ARG LEU ASN TRP LEU THR SER SEQRES 13 C 514 LEU ASN ASN ILE TYR PRO ALA GLN ASN VAL THR MET PRO SEQRES 14 C 514 ASN LYS GLU GLN PHE ASP LYS LEU TYR ILE TRP GLY VAL SEQRES 15 C 514 HIS HIS PRO ASP THR ASP LYS ASN GLN ILE SER LEU PHE SEQRES 16 C 514 ALA GLN SER SER GLY ARG ILE THR VAL SER THR LYS ARG SEQRES 17 C 514 SER GLN GLN ALA VAL ILE PRO ASN ILE GLY SER ARG PRO SEQRES 18 C 514 ARG ILE ARG ASP ILE PRO SER ARG ILE SER ILE TYR TRP SEQRES 19 C 514 THR ILE VAL LYS PRO GLY ASP ILE LEU LEU ILE ASN SER SEQRES 20 C 514 THR GLY ASN LEU ILE ALA PRO ARG GLY TYR PHE LYS ILE SEQRES 21 C 514 ARG SER GLY LYS SER SER ILE MET ARG SER ASP ALA PRO SEQRES 22 C 514 ILE GLY LYS CYS LYS SER GLU CYS ILE THR PRO ASN GLY SEQRES 23 C 514 SER ILE PRO ASN ASP LYS PRO PHE GLN ASN VAL ASN ARG SEQRES 24 C 514 ILE THR TYR GLY ALA CYS PRO ARG TYR VAL LYS GLN SER SEQRES 25 C 514 THR LEU LYS LEU ALA THR GLY MET ARG ASN VAL PRO GLU SEQRES 26 C 514 LYS GLN THR ARG GLY ILE PHE GLY ALA ILE ALA GLY PHE SEQRES 27 C 514 ILE GLU ASN GLY TRP GLU GLY MET VAL ASP GLY TRP TYR SEQRES 28 C 514 GLY PHE ARG TRP GLN ASN SER GLU GLY ARG GLY GLN ALA SEQRES 29 C 514 ALA ASP LEU LYS SER THR GLN ALA ALA ILE ASP GLN ILE SEQRES 30 C 514 ASN GLY ILE LEU ASN ARG LEU ILE GLY LYS THR ASN GLU SEQRES 31 C 514 LYS PHE HIS GLN ILE GLU LYS GLU PHE SER GLU VAL GLU SEQRES 32 C 514 GLY ARG VAL GLN ASP LEU GLU LYS TYR VAL GLU ASP THR SEQRES 33 C 514 LYS ILE ASP LEU TRP SER TYR ASN ALA GLU LEU LEU VAL SEQRES 34 C 514 ALA LEU ILE ASN GLN HIS THR ILE ASP LEU THR ASP SER SEQRES 35 C 514 GLU MET ASN LYS LEU PHE GLU LYS THR LYS LYS GLN LEU SEQRES 36 C 514 ARG GLU ASN ALA GLU ASP MET GLY ASN GLY CYS PHE LYS SEQRES 37 C 514 ILE TYR HIS LYS CYS ASP ASN ALA CYS ILE GLY SER ILE SEQRES 38 C 514 ARG ASN GLU THR TYR ASP HIS ASN VAL TYR ARG ASP GLU SEQRES 39 C 514 ALA LEU ASN ASN ARG PHE GLN ILE LYS GLY ALA GLY SER SEQRES 40 C 514 SER LEU GLU VAL LEU PHE GLN SEQRES 1 D 239 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 D 239 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 D 239 PHE THR PHE HIS ASN TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 D 239 ALA PRO GLY LYS GLY LEU ASP TRP VAL THR GLY ILE THR SEQRES 5 D 239 TRP ASN SER VAL ASN VAL ASP TYR ALA ASP SER VAL LYS SEQRES 6 D 239 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 D 239 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 D 239 ALA LEU TYR TYR CYS VAL LYS GLY GLN VAL TRP SER GLY SEQRES 9 D 239 TYR TYR LEU THR HIS ASP ALA PHE ASP LEU TRP GLY GLN SEQRES 10 D 239 GLY THR THR VAL THR VAL SER GLY ALA SER THR LYS GLY SEQRES 11 D 239 PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SEQRES 12 D 239 SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP SEQRES 13 D 239 TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY SEQRES 14 D 239 ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU SEQRES 15 D 239 GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR SEQRES 16 D 239 VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS SEQRES 17 D 239 ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS SEQRES 18 D 239 ARG VAL GLU PRO LYS SER CYS ASP LYS GLY SER SER LEU SEQRES 19 D 239 GLU VAL LEU PHE GLN SEQRES 1 E 239 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 E 239 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 E 239 PHE THR PHE HIS ASN TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 E 239 ALA PRO GLY LYS GLY LEU ASP TRP VAL THR GLY ILE THR SEQRES 5 E 239 TRP ASN SER VAL ASN VAL ASP TYR ALA ASP SER VAL LYS SEQRES 6 E 239 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 E 239 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 E 239 ALA LEU TYR TYR CYS VAL LYS GLY GLN VAL TRP SER GLY SEQRES 9 E 239 TYR TYR LEU THR HIS ASP ALA PHE ASP LEU TRP GLY GLN SEQRES 10 E 239 GLY THR THR VAL THR VAL SER GLY ALA SER THR LYS GLY SEQRES 11 E 239 PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SEQRES 12 E 239 SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP SEQRES 13 E 239 TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY SEQRES 14 E 239 ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU SEQRES 15 E 239 GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR SEQRES 16 E 239 VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS SEQRES 17 E 239 ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS SEQRES 18 E 239 ARG VAL GLU PRO LYS SER CYS ASP LYS GLY SER SER LEU SEQRES 19 E 239 GLU VAL LEU PHE GLN SEQRES 1 F 239 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 F 239 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 F 239 PHE THR PHE HIS ASN TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 F 239 ALA PRO GLY LYS GLY LEU ASP TRP VAL THR GLY ILE THR SEQRES 5 F 239 TRP ASN SER VAL ASN VAL ASP TYR ALA ASP SER VAL LYS SEQRES 6 F 239 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 F 239 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 F 239 ALA LEU TYR TYR CYS VAL LYS GLY GLN VAL TRP SER GLY SEQRES 9 F 239 TYR TYR LEU THR HIS ASP ALA PHE ASP LEU TRP GLY GLN SEQRES 10 F 239 GLY THR THR VAL THR VAL SER GLY ALA SER THR LYS GLY SEQRES 11 F 239 PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SEQRES 12 F 239 SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP SEQRES 13 F 239 TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY SEQRES 14 F 239 ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU SEQRES 15 F 239 GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR SEQRES 16 F 239 VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS SEQRES 17 F 239 ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS SEQRES 18 F 239 ARG VAL GLU PRO LYS SER CYS ASP LYS GLY SER SER LEU SEQRES 19 F 239 GLU VAL LEU PHE GLN SEQRES 1 G 214 ASP ILE VAL MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 G 214 THR VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 G 214 GLN SER ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 G 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE SER GLY ALA SER SEQRES 5 G 214 SER LEU GLN LEU GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 G 214 GLU SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 G 214 GLN PRO GLU ASP CYS ALA THR TYR TYR CYS GLN GLN GLY SEQRES 8 G 214 TYR ILE MET PRO GLY THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 G 214 ASP ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 G 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 G 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 G 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 G 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 G 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 G 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 G 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 G 214 PHE ASN ARG GLY GLU CYS SEQRES 1 H 214 ASP ILE VAL MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 H 214 THR VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 H 214 GLN SER ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 H 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE SER GLY ALA SER SEQRES 5 H 214 SER LEU GLN LEU GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 H 214 GLU SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 H 214 GLN PRO GLU ASP CYS ALA THR TYR TYR CYS GLN GLN GLY SEQRES 8 H 214 TYR ILE MET PRO GLY THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 H 214 ASP ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 H 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 H 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 H 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 H 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 H 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 H 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 H 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 H 214 PHE ASN ARG GLY GLU CYS SEQRES 1 I 214 ASP ILE VAL MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 I 214 THR VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 I 214 GLN SER ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 I 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE SER GLY ALA SER SEQRES 5 I 214 SER LEU GLN LEU GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 I 214 GLU SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 I 214 GLN PRO GLU ASP CYS ALA THR TYR TYR CYS GLN GLN GLY SEQRES 8 I 214 TYR ILE MET PRO GLY THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 I 214 ASP ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 I 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 I 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 I 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 I 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 I 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 I 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 I 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 I 214 PHE ASN ARG GLY GLU CYS HET NAG J 1 14 HET NAG J 2 14 HET BMA J 3 11 HET MAN J 4 11 HET MAN J 5 11 HET MAN J 6 11 HET MAN J 7 11 HET MAN J 8 11 HET NAG K 1 14 HET NAG K 2 14 HET BMA K 3 11 HET NAG L 1 14 HET NAG L 2 14 HET BMA L 3 11 HET MAN L 4 11 HET MAN L 5 11 HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET BMA N 3 11 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET MAN O 4 11 HET MAN O 5 11 HET MAN O 6 11 HET MAN O 7 11 HET MAN O 8 11 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET MAN P 4 11 HET MAN P 5 11 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET BMA S 3 11 HET MAN S 4 11 HET MAN S 5 11 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET MAN U 6 11 HET MAN U 7 11 HET MAN U 8 11 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG B 601 14 HET NAG B 602 14 HET NAG C 601 14 HET NAG C 602 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 35(C8 H15 N O6) FORMUL 10 BMA 9(C6 H12 O6) FORMUL 10 MAN 21(C6 H12 O6) HELIX 1 AA1 THR A 65 LEU A 71 1 7 HELIX 2 AA2 CYS A 76 GLN A 80 5 5 HELIX 3 AA3 ASP A 104 GLY A 116 1 13 HELIX 4 AA4 THR A 187 PHE A 195 1 9 HELIX 5 AA5 ASP A 366 ILE A 385 1 20 HELIX 6 AA6 GLY A 404 GLU A 443 1 40 HELIX 7 AA7 THR B 65 GLY B 72 1 8 HELIX 8 AA8 ASP B 73 GLN B 80 5 8 HELIX 9 AA9 ASP B 104 GLY B 116 1 13 HELIX 10 AB1 THR B 187 PHE B 195 1 9 HELIX 11 AB2 ASP B 366 ILE B 385 1 20 HELIX 12 AB3 GLY B 404 GLU B 443 1 40 HELIX 13 AB4 THR C 65 GLY C 72 1 8 HELIX 14 AB5 PRO C 74 GLN C 80 5 7 HELIX 15 AB6 ASP C 104 GLY C 116 1 13 HELIX 16 AB7 THR C 187 ALA C 196 1 10 HELIX 17 AB8 ASP C 366 ILE C 385 1 20 HELIX 18 AB9 GLY C 404 GLU C 443 1 40 HELIX 19 AC1 THR D 28 TYR D 32 5 5 HELIX 20 AC2 ASP D 62 LYS D 65 5 4 HELIX 21 AC3 ARG D 87 THR D 91 5 5 HELIX 22 AC4 THR E 28 TYR E 32 5 5 HELIX 23 AC5 ASP E 62 LYS E 65 5 4 HELIX 24 AC6 ARG E 87 THR E 91 5 5 HELIX 25 AC7 TRP F 53 VAL F 56 5 4 HELIX 26 AC8 ASP F 62 LYS F 65 5 4 HELIX 27 AC9 ARG F 87 THR F 91 5 5 HELIX 28 AD1 GLN G 79 CYS G 83 5 5 HELIX 29 AD2 GLN H 79 CYS H 83 5 5 SHEET 1 AA1 2 THR A 24 VAL A 26 0 SHEET 2 AA1 2 ILE A 34 VAL A 36 -1 O VAL A 36 N THR A 24 SHEET 1 AA2 2 ALA A 39 GLU A 41 0 SHEET 2 AA2 2 LYS A 315 ALA A 317 -1 O LEU A 316 N THR A 40 SHEET 1 AA3 3 VAL A 43 GLN A 44 0 SHEET 2 AA3 3 PHE A 294 GLN A 295 1 O PHE A 294 N GLN A 44 SHEET 3 AA3 3 ARG A 307 TYR A 308 1 O ARG A 307 N GLN A 295 SHEET 1 AA4 2 ILE A 51 CYS A 52 0 SHEET 2 AA4 2 ILE A 274 GLY A 275 1 O GLY A 275 N ILE A 51 SHEET 1 AA5 3 ILE A 58 GLY A 61 0 SHEET 2 AA5 3 LEU A 86 GLU A 89 1 O LEU A 86 N LEU A 59 SHEET 3 AA5 3 SER A 266 ARG A 269 1 O MET A 268 N PHE A 87 SHEET 1 AA6 5 LYS A 121 ASN A 122 0 SHEET 2 AA6 5 GLY A 256 LYS A 259 -1 O TYR A 257 N LYS A 121 SHEET 3 AA6 5 LYS A 176 HIS A 184 -1 N LEU A 177 O PHE A 258 SHEET 4 AA6 5 LEU A 251 PRO A 254 -1 O ILE A 252 N GLY A 181 SHEET 5 AA6 5 LEU A 151 TRP A 153 -1 N ASN A 152 O ALA A 253 SHEET 1 AA7 4 LYS A 121 ASN A 122 0 SHEET 2 AA7 4 GLY A 256 LYS A 259 -1 O TYR A 257 N LYS A 121 SHEET 3 AA7 4 LYS A 176 HIS A 184 -1 N LEU A 177 O PHE A 258 SHEET 4 AA7 4 ARG A 229 VAL A 237 -1 O ARG A 229 N HIS A 184 SHEET 1 AA8 2 SER A 136 ARG A 141 0 SHEET 2 AA8 2 SER A 144 SER A 146 -1 O SER A 144 N ARG A 141 SHEET 1 AA9 4 GLN A 164 PRO A 169 0 SHEET 2 AA9 4 ILE A 242 SER A 247 -1 O SER A 247 N GLN A 164 SHEET 3 AA9 4 ILE A 202 SER A 205 -1 N SER A 205 O LEU A 244 SHEET 4 AA9 4 GLN A 210 VAL A 213 -1 O GLN A 211 N VAL A 204 SHEET 1 AB1 2 CYS A 281 THR A 283 0 SHEET 2 AB1 2 GLY A 286 ILE A 288 -1 O ILE A 288 N CYS A 281 SHEET 1 AB2 2 GLY A 303 ALA A 304 0 SHEET 2 AB2 2 GLU A 390 LYS A 391 -1 O LYS A 391 N GLY A 303 SHEET 1 AB3 2 THR B 24 VAL B 26 0 SHEET 2 AB3 2 ILE B 34 VAL B 36 -1 O VAL B 36 N THR B 24 SHEET 1 AB4 2 THR B 40 GLU B 41 0 SHEET 2 AB4 2 LYS B 315 LEU B 316 -1 O LEU B 316 N THR B 40 SHEET 1 AB5 3 VAL B 43 GLN B 44 0 SHEET 2 AB5 3 PHE B 294 GLN B 295 1 O PHE B 294 N GLN B 44 SHEET 3 AB5 3 ARG B 307 TYR B 308 1 O ARG B 307 N GLN B 295 SHEET 1 AB6 2 ILE B 51 CYS B 52 0 SHEET 2 AB6 2 ILE B 274 GLY B 275 1 O GLY B 275 N ILE B 51 SHEET 1 AB7 3 ILE B 58 GLY B 61 0 SHEET 2 AB7 3 LEU B 86 GLU B 89 1 O VAL B 88 N LEU B 59 SHEET 3 AB7 3 SER B 266 ARG B 269 1 O MET B 268 N GLU B 89 SHEET 1 AB8 5 LYS B 121 ASN B 122 0 SHEET 2 AB8 5 GLY B 256 LYS B 259 -1 O TYR B 257 N LYS B 121 SHEET 3 AB8 5 LYS B 176 HIS B 184 -1 N LEU B 177 O PHE B 258 SHEET 4 AB8 5 LEU B 251 PRO B 254 -1 O ILE B 252 N GLY B 181 SHEET 5 AB8 5 LEU B 151 TRP B 153 -1 N ASN B 152 O ALA B 253 SHEET 1 AB9 4 LYS B 121 ASN B 122 0 SHEET 2 AB9 4 GLY B 256 LYS B 259 -1 O TYR B 257 N LYS B 121 SHEET 3 AB9 4 LYS B 176 HIS B 184 -1 N LEU B 177 O PHE B 258 SHEET 4 AB9 4 ARG B 229 VAL B 237 -1 O THR B 235 N TYR B 178 SHEET 1 AC1 2 SER B 136 ARG B 141 0 SHEET 2 AC1 2 SER B 144 SER B 146 -1 O SER B 146 N CYS B 139 SHEET 1 AC2 4 VAL B 166 PRO B 169 0 SHEET 2 AC2 4 ILE B 242 ILE B 245 -1 O LEU B 243 N MET B 168 SHEET 3 AC2 4 ILE B 202 SER B 205 -1 N SER B 205 O LEU B 244 SHEET 4 AC2 4 GLN B 210 VAL B 213 -1 O GLN B 211 N VAL B 204 SHEET 1 AC3 2 CYS B 281 THR B 283 0 SHEET 2 AC3 2 GLY B 286 ILE B 288 -1 O GLY B 286 N THR B 283 SHEET 1 AC4 2 GLY B 303 ALA B 304 0 SHEET 2 AC4 2 GLU B 390 LYS B 391 -1 O LYS B 391 N GLY B 303 SHEET 1 AC5 2 THR C 24 VAL C 26 0 SHEET 2 AC5 2 ILE C 34 VAL C 36 -1 O ILE C 34 N VAL C 26 SHEET 1 AC6 2 ALA C 39 GLU C 41 0 SHEET 2 AC6 2 LYS C 315 ALA C 317 -1 O LEU C 316 N THR C 40 SHEET 1 AC7 3 VAL C 43 GLN C 44 0 SHEET 2 AC7 3 PHE C 294 GLN C 295 1 O PHE C 294 N GLN C 44 SHEET 3 AC7 3 ARG C 307 TYR C 308 1 O ARG C 307 N GLN C 295 SHEET 1 AC8 3 ILE C 58 GLY C 61 0 SHEET 2 AC8 3 LEU C 86 GLU C 89 1 O VAL C 88 N LEU C 59 SHEET 3 AC8 3 SER C 266 ARG C 269 1 O MET C 268 N PHE C 87 SHEET 1 AC9 5 PHE C 120 ASN C 122 0 SHEET 2 AC9 5 GLY C 256 LYS C 259 -1 O TYR C 257 N LYS C 121 SHEET 3 AC9 5 LYS C 176 HIS C 184 -1 N LEU C 177 O PHE C 258 SHEET 4 AC9 5 LEU C 251 PRO C 254 -1 O ILE C 252 N GLY C 181 SHEET 5 AC9 5 LEU C 151 TRP C 153 -1 N ASN C 152 O ALA C 253 SHEET 1 AD1 4 PHE C 120 ASN C 122 0 SHEET 2 AD1 4 GLY C 256 LYS C 259 -1 O TYR C 257 N LYS C 121 SHEET 3 AD1 4 LYS C 176 HIS C 184 -1 N LEU C 177 O PHE C 258 SHEET 4 AD1 4 ARG C 229 VAL C 237 -1 O SER C 231 N VAL C 182 SHEET 1 AD2 2 SER C 136 ARG C 141 0 SHEET 2 AD2 2 SER C 144 SER C 146 -1 O SER C 146 N CYS C 139 SHEET 1 AD3 4 VAL C 166 PRO C 169 0 SHEET 2 AD3 4 ILE C 242 ILE C 245 -1 O LEU C 243 N MET C 168 SHEET 3 AD3 4 ILE C 202 SER C 205 -1 N SER C 205 O LEU C 244 SHEET 4 AD3 4 GLN C 210 VAL C 213 -1 O GLN C 211 N VAL C 204 SHEET 1 AD4 2 CYS C 281 THR C 283 0 SHEET 2 AD4 2 GLY C 286 ILE C 288 -1 O ILE C 288 N CYS C 281 SHEET 1 AD5 4 GLN D 3 SER D 7 0 SHEET 2 AD5 4 LEU D 18 SER D 25 -1 O SER D 25 N GLN D 3 SHEET 3 AD5 4 SER D 78 MET D 83 -1 O MET D 83 N LEU D 18 SHEET 4 AD5 4 PHE D 68 ASP D 73 -1 N THR D 69 O GLN D 82 SHEET 1 AD6 6 GLY D 10 VAL D 12 0 SHEET 2 AD6 6 THR D 119 VAL D 123 1 O THR D 122 N VAL D 12 SHEET 3 AD6 6 ALA D 92 GLY D 99 -1 N TYR D 94 O THR D 119 SHEET 4 AD6 6 MET D 34 GLN D 39 -1 N VAL D 37 O TYR D 95 SHEET 5 AD6 6 LEU D 45 ILE D 51 -1 O ILE D 51 N MET D 34 SHEET 6 AD6 6 VAL D 58 TYR D 60 -1 O ASP D 59 N GLY D 50 SHEET 1 AD7 4 GLY D 10 VAL D 12 0 SHEET 2 AD7 4 THR D 119 VAL D 123 1 O THR D 122 N VAL D 12 SHEET 3 AD7 4 ALA D 92 GLY D 99 -1 N TYR D 94 O THR D 119 SHEET 4 AD7 4 PHE D 112 LEU D 114 -1 O LEU D 114 N LYS D 98 SHEET 1 AD8 4 GLN E 3 SER E 7 0 SHEET 2 AD8 4 LEU E 18 SER E 25 -1 O SER E 21 N SER E 7 SHEET 3 AD8 4 SER E 78 MET E 83 -1 O MET E 83 N LEU E 18 SHEET 4 AD8 4 PHE E 68 ASP E 73 -1 N ASP E 73 O SER E 78 SHEET 1 AD9 6 GLY E 10 VAL E 12 0 SHEET 2 AD9 6 THR E 119 VAL E 123 1 O THR E 122 N VAL E 12 SHEET 3 AD9 6 ALA E 92 GLY E 99 -1 N TYR E 94 O THR E 119 SHEET 4 AD9 6 MET E 34 GLN E 39 -1 N GLN E 39 O LEU E 93 SHEET 5 AD9 6 LEU E 45 ILE E 51 -1 O THR E 49 N TRP E 36 SHEET 6 AD9 6 VAL E 58 TYR E 60 -1 O ASP E 59 N GLY E 50 SHEET 1 AE1 4 GLY E 10 VAL E 12 0 SHEET 2 AE1 4 THR E 119 VAL E 123 1 O THR E 122 N VAL E 12 SHEET 3 AE1 4 ALA E 92 GLY E 99 -1 N TYR E 94 O THR E 119 SHEET 4 AE1 4 PHE E 112 TRP E 115 -1 O LEU E 114 N LYS E 98 SHEET 1 AE2 4 GLN F 3 SER F 7 0 SHEET 2 AE2 4 LEU F 18 SER F 25 -1 O ALA F 23 N VAL F 5 SHEET 3 AE2 4 SER F 78 MET F 83 -1 O MET F 83 N LEU F 18 SHEET 4 AE2 4 PHE F 68 ASP F 73 -1 N SER F 71 O TYR F 80 SHEET 1 AE3 6 GLY F 10 VAL F 12 0 SHEET 2 AE3 6 THR F 119 VAL F 123 1 O THR F 122 N GLY F 10 SHEET 3 AE3 6 ALA F 92 GLY F 99 -1 N TYR F 94 O THR F 119 SHEET 4 AE3 6 MET F 34 GLN F 39 -1 N HIS F 35 O VAL F 97 SHEET 5 AE3 6 LEU F 45 ILE F 51 -1 O ASP F 46 N ARG F 38 SHEET 6 AE3 6 VAL F 58 TYR F 60 -1 O ASP F 59 N GLY F 50 SHEET 1 AE4 4 GLY F 10 VAL F 12 0 SHEET 2 AE4 4 THR F 119 VAL F 123 1 O THR F 122 N GLY F 10 SHEET 3 AE4 4 ALA F 92 GLY F 99 -1 N TYR F 94 O THR F 119 SHEET 4 AE4 4 PHE F 112 TRP F 115 -1 O LEU F 114 N LYS F 98 SHEET 1 AE5 4 MET G 4 GLN G 6 0 SHEET 2 AE5 4 VAL G 19 ALA G 25 -1 O ARG G 24 N THR G 5 SHEET 3 AE5 4 ASP G 70 ILE G 75 -1 O ILE G 75 N VAL G 19 SHEET 4 AE5 4 PHE G 62 SER G 67 -1 N SER G 63 O THR G 74 SHEET 1 AE6 6 SER G 10 ALA G 13 0 SHEET 2 AE6 6 THR G 102 ILE G 106 1 O LYS G 103 N LEU G 11 SHEET 3 AE6 6 THR G 85 GLN G 90 -1 N TYR G 86 O THR G 102 SHEET 4 AE6 6 LEU G 33 GLN G 38 -1 N TYR G 36 O TYR G 87 SHEET 5 AE6 6 LYS G 45 SER G 49 -1 O LEU G 47 N TRP G 35 SHEET 6 AE6 6 SER G 53 LEU G 54 -1 O SER G 53 N SER G 49 SHEET 1 AE7 4 MET H 4 GLN H 6 0 SHEET 2 AE7 4 VAL H 19 ALA H 25 -1 O ARG H 24 N THR H 5 SHEET 3 AE7 4 ASP H 70 ILE H 75 -1 O ILE H 75 N VAL H 19 SHEET 4 AE7 4 PHE H 62 SER H 67 -1 N SER H 67 O ASP H 70 SHEET 1 AE8 6 SER H 10 ALA H 13 0 SHEET 2 AE8 6 THR H 102 ILE H 106 1 O LYS H 103 N LEU H 11 SHEET 3 AE8 6 THR H 85 GLN H 90 -1 N TYR H 86 O THR H 102 SHEET 4 AE8 6 LEU H 33 GLN H 38 -1 N GLN H 38 O THR H 85 SHEET 5 AE8 6 LYS H 45 SER H 49 -1 O LEU H 47 N TRP H 35 SHEET 6 AE8 6 SER H 53 LEU H 54 -1 O SER H 53 N SER H 49 SHEET 1 AE9 4 THR I 5 SER I 7 0 SHEET 2 AE9 4 VAL I 19 ARG I 24 -1 O THR I 22 N SER I 7 SHEET 3 AE9 4 ASP I 70 ILE I 75 -1 O ILE I 75 N VAL I 19 SHEET 4 AE9 4 PHE I 62 SER I 67 -1 N SER I 63 O THR I 74 SHEET 1 AF1 6 SER I 10 ALA I 13 0 SHEET 2 AF1 6 THR I 102 ILE I 106 1 O LYS I 103 N LEU I 11 SHEET 3 AF1 6 THR I 85 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AF1 6 LEU I 33 GLN I 38 -1 N ASN I 34 O GLN I 89 SHEET 5 AF1 6 LYS I 45 SER I 49 -1 O LEU I 47 N TRP I 35 SHEET 6 AF1 6 SER I 53 LEU I 54 -1 O SER I 53 N SER I 49 SSBOND 1 CYS A 52 CYS A 277 1555 1555 2.03 SSBOND 2 CYS A 64 CYS A 76 1555 1555 2.03 SSBOND 3 CYS A 97 CYS A 139 1555 1555 2.02 SSBOND 4 CYS A 281 CYS A 305 1555 1555 2.03 SSBOND 5 CYS B 64 CYS B 76 1555 1555 2.03 SSBOND 6 CYS B 97 CYS B 139 1555 1555 2.03 SSBOND 7 CYS B 281 CYS B 305 1555 1555 2.03 SSBOND 8 CYS C 52 CYS C 277 1555 1555 2.03 SSBOND 9 CYS C 64 CYS C 76 1555 1555 2.03 SSBOND 10 CYS C 97 CYS C 139 1555 1555 2.03 SSBOND 11 CYS C 281 CYS C 305 1555 1555 2.03 SSBOND 12 CYS D 22 CYS D 96 1555 1555 2.03 SSBOND 13 CYS E 22 CYS E 96 1555 1555 2.03 SSBOND 14 CYS F 22 CYS F 96 1555 1555 2.03 SSBOND 15 CYS G 23 CYS G 88 1555 1555 2.04 SSBOND 16 CYS I 23 CYS I 88 1555 1555 2.04 LINK ND2 ASN A 38 C1 NAG A 603 1555 1555 1.44 LINK ND2 ASN A 63 C1 NAG A 602 1555 1555 1.44 LINK ND2 ASN A 126 C1 NAG A 601 1555 1555 1.44 LINK ND2 ASN A 133 C1 NAG J 1 1555 1555 1.44 LINK ND2 ASN A 165 C1 NAG L 1 1555 1555 1.44 LINK ND2 ASN A 246 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN A 285 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN B 38 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN B 63 C1 NAG B 602 1555 1555 1.44 LINK ND2 ASN B 126 C1 NAG B 601 1555 1555 1.45 LINK ND2 ASN B 133 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN B 165 C1 NAG P 1 1555 1555 1.45 LINK ND2 ASN B 246 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN B 285 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN C 38 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN C 63 C1 NAG C 602 1555 1555 1.45 LINK ND2 ASN C 126 C1 NAG C 601 1555 1555 1.44 LINK ND2 ASN C 133 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN C 165 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN C 246 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN C 285 C1 NAG V 1 1555 1555 1.44 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG J 2 C1 BMA J 3 1555 1555 1.45 LINK O3 BMA J 3 C1 MAN J 4 1555 1555 1.46 LINK O6 BMA J 3 C1 MAN J 6 1555 1555 1.45 LINK O6 MAN J 4 C1 MAN J 5 1555 1555 1.45 LINK O3 MAN J 6 C1 MAN J 7 1555 1555 1.44 LINK O6 MAN J 6 C1 MAN J 8 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.45 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.44 LINK O4 NAG L 2 C1 BMA L 3 1555 1555 1.45 LINK O3 BMA L 3 C1 MAN L 4 1555 1555 1.44 LINK O6 BMA L 3 C1 MAN L 5 1555 1555 1.45 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG N 2 C1 BMA N 3 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.45 LINK O3 BMA O 3 C1 MAN O 4 1555 1555 1.44 LINK O6 BMA O 3 C1 MAN O 6 1555 1555 1.44 LINK O3 MAN O 4 C1 MAN O 5 1555 1555 1.44 LINK O3 MAN O 6 C1 MAN O 7 1555 1555 1.44 LINK O6 MAN O 6 C1 MAN O 8 1555 1555 1.45 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.44 LINK O3 BMA P 3 C1 MAN P 4 1555 1555 1.45 LINK O6 BMA P 3 C1 MAN P 5 1555 1555 1.45 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.45 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG S 2 C1 BMA S 3 1555 1555 1.44 LINK O3 BMA S 3 C1 MAN S 4 1555 1555 1.44 LINK O6 BMA S 3 C1 MAN S 5 1555 1555 1.45 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.45 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.45 LINK O6 BMA U 3 C1 MAN U 6 1555 1555 1.45 LINK O3 MAN U 4 C1 MAN U 5 1555 1555 1.44 LINK O3 MAN U 6 C1 MAN U 7 1555 1555 1.45 LINK O6 MAN U 6 C1 MAN U 8 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.45 CISPEP 1 MET G 94 PRO G 95 0 6.21 CISPEP 2 SER I 7 PRO I 8 0 -5.13 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000