HEADER VIRAL PROTEIN/IMMUNE SYSTEM 16-APR-24 9BEW TITLE CRYO-EM STRUCTURE OF THE HIV-1 BG505 IDL ENV TRIMER IN COMPLEX WITH TITLE 2 3BNC117 AND 10-1074 FABS CAVEAT 9BEW MAN Z 6 HAS WRONG CHIRALITY AT ATOM C1 MAN H 6 HAS WRONG CAVEAT 2 9BEW CHIRALITY AT ATOM C1 MAN P 6 HAS WRONG CHIRALITY AT ATOM C1 COMPND MOL_ID: 1; COMPND 2 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; COMPND 3 CHAIN: G, A, M; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: ENVELOPE GLYCOPROTEIN GP41; COMPND 7 CHAIN: B, E, N; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: 3BNC117 HEAVY CHAIN; COMPND 11 CHAIN: C, F, O; COMPND 12 FRAGMENT: FAB; COMPND 13 ENGINEERED: YES; COMPND 14 MOL_ID: 4; COMPND 15 MOLECULE: 3BNC117 LIGHT CHAIN; COMPND 16 CHAIN: D, I, P; COMPND 17 FRAGMENT: FAB; COMPND 18 ENGINEERED: YES; COMPND 19 MOL_ID: 5; COMPND 20 MOLECULE: 10-1074 HEAVY CHAIN; COMPND 21 CHAIN: H, J, Q; COMPND 22 FRAGMENT: FAB; COMPND 23 ENGINEERED: YES; COMPND 24 MOL_ID: 6; COMPND 25 MOLECULE: 10-1074 LIGHT CHAIN; COMPND 26 CHAIN: L, K, R; COMPND 27 FRAGMENT: FAB; COMPND 28 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_COMMON: HIV-1; SOURCE 4 ORGANISM_TAXID: 11676; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 10 ORGANISM_COMMON: HIV-1; SOURCE 11 ORGANISM_TAXID: 11676; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_COMMON: HUMAN; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 24 ORGANISM_COMMON: HUMAN; SOURCE 25 ORGANISM_TAXID: 9606; SOURCE 26 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 27 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 28 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 29 MOL_ID: 5; SOURCE 30 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 31 ORGANISM_COMMON: HUMAN; SOURCE 32 ORGANISM_TAXID: 9606; SOURCE 33 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 34 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 35 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 36 MOL_ID: 6; SOURCE 37 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 38 ORGANISM_COMMON: HUMAN; SOURCE 39 ORGANISM_TAXID: 9606; SOURCE 40 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 41 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 42 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS CD4, HIV-1, SOSIP, VACCINE, GP120, GP41, VIRAL PROTEIN-IMMUNE SYSTEM KEYWDS 2 COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR J.GORMAN,P.D.KWONG JRNL AUTH P.ZHANG,J.GORMAN,Y.TSYBOVSKY,M.LU,Q.LIU,V.GOPAN,M.SINGH, JRNL AUTH 2 Y.LIN,H.MIAO,Y.SEO,A.KWON,A.S.OLIA,G.Y.CHUANG,H.GENG, JRNL AUTH 3 Y.T.LAI,T.ZHOU,J.R.MASCOLA,W.MOTHES,P.D.KWONG,P.LUSSO JRNL TITL DESIGN OF SOLUBLE HIV-1 ENVELOPE TRIMERS FREE OF COVALENT JRNL TITL 2 GP120-GP41 BONDS WITH PREVALENT NATIVE-LIKE CONFORMATION. JRNL REF CELL REP V. 43 14518 2024 JRNL REFN ESSN 2211-1247 JRNL PMID 39028623 JRNL DOI 10.1016/J.CELREP.2024.114518 REMARK 2 REMARK 2 RESOLUTION. 3.30 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : LEGINON, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 5V8M REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.300 REMARK 3 NUMBER OF PARTICLES : 50380 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9BEW COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB. REMARK 100 THE DEPOSITION ID IS D_1000283211. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF THE HIV-1 REMARK 245 BG505 IDL ENV TRIMER IN COMPLEX REMARK 245 WITH 3BNC117 AND 10-1074 FABS REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 2.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 160.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 63.90 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, B, C, D, H, L, A, E, F, I, REMARK 350 AND CHAINS: J, K, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i, j, k, l, REMARK 350 AND CHAINS: m, n, o, p REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA G 31 REMARK 465 GLU G 32 REMARK 465 TYR G 61 REMARK 465 GLU G 62 REMARK 465 THR G 63 REMARK 465 GLU G 64 REMARK 465 ASP G 148 REMARK 465 ASP G 149 REMARK 465 GLU G 185A REMARK 465 ASN G 185B REMARK 465 GLN G 185C REMARK 465 GLY G 185D REMARK 465 ASN G 185E REMARK 465 ARG G 185F REMARK 465 SER G 185G REMARK 465 ASN G 185H REMARK 465 ASN G 185I REMARK 465 SER G 185J REMARK 465 ASN G 185K REMARK 465 THR G 400 REMARK 465 SER G 401 REMARK 465 VAL G 402 REMARK 465 GLN G 403 REMARK 465 GLY G 404 REMARK 465 SER G 405 REMARK 465 ASN G 406 REMARK 465 SER G 407 REMARK 465 THR G 408 REMARK 465 GLY G 409 REMARK 465 SER G 410 REMARK 465 VAL G 506 REMARK 465 GLY G 507 REMARK 465 ARG G 508 REMARK 465 ARG G 509 REMARK 465 ARG G 510 REMARK 465 ARG G 511 REMARK 465 ARG G 512 REMARK 465 ARG G 513 REMARK 465 ALA B 512 REMARK 465 VAL B 513 REMARK 465 GLY B 514 REMARK 465 ILE B 515 REMARK 465 GLY B 516 REMARK 465 ALA B 517 REMARK 465 VAL B 518 REMARK 465 PHE B 519 REMARK 465 GLY B 547 REMARK 465 ILE B 548 REMARK 465 VAL B 549 REMARK 465 GLN B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 SER B 553 REMARK 465 ASN B 554 REMARK 465 LEU B 555 REMARK 465 LEU B 556 REMARK 465 ARG B 557 REMARK 465 ALA B 558 REMARK 465 PRO B 559 REMARK 465 ASP B 659 REMARK 465 LEU B 660 REMARK 465 LEU B 661 REMARK 465 ALA B 662 REMARK 465 LEU B 663 REMARK 465 ASP B 664 REMARK 465 SER C 112 REMARK 465 SER C 113 REMARK 465 ALA C 114 REMARK 465 SER C 115 REMARK 465 THR C 116 REMARK 465 LYS C 117 REMARK 465 GLY C 118 REMARK 465 PRO C 119 REMARK 465 SER C 120 REMARK 465 VAL C 121 REMARK 465 PHE C 122 REMARK 465 PRO C 123 REMARK 465 LEU C 124 REMARK 465 ALA C 125 REMARK 465 PRO C 126 REMARK 465 SER C 127 REMARK 465 SER C 128 REMARK 465 LYS C 129 REMARK 465 SER C 130 REMARK 465 THR C 131 REMARK 465 SER C 132 REMARK 465 GLY C 133 REMARK 465 GLY C 134 REMARK 465 THR C 135 REMARK 465 ALA C 136 REMARK 465 ALA C 137 REMARK 465 LEU C 138 REMARK 465 GLY C 139 REMARK 465 CYS C 140 REMARK 465 LEU C 141 REMARK 465 VAL C 142 REMARK 465 LYS C 143 REMARK 465 ASP C 144 REMARK 465 TYR C 145 REMARK 465 PHE C 146 REMARK 465 PRO C 147 REMARK 465 GLU C 148 REMARK 465 PRO C 149 REMARK 465 VAL C 150 REMARK 465 THR C 151 REMARK 465 VAL C 152 REMARK 465 SER C 153 REMARK 465 TRP C 154 REMARK 465 ASN C 155 REMARK 465 SER C 156 REMARK 465 GLY C 157 REMARK 465 ALA C 158 REMARK 465 LEU C 159 REMARK 465 THR C 160 REMARK 465 SER C 161 REMARK 465 GLY C 162 REMARK 465 VAL C 163 REMARK 465 HIS C 164 REMARK 465 THR C 165 REMARK 465 PHE C 166 REMARK 465 PRO C 167 REMARK 465 ALA C 168 REMARK 465 VAL C 169 REMARK 465 LEU C 170 REMARK 465 GLN C 171 REMARK 465 SER C 172 REMARK 465 SER C 173 REMARK 465 GLY C 174 REMARK 465 LEU C 175 REMARK 465 TYR C 176 REMARK 465 SER C 177 REMARK 465 LEU C 178 REMARK 465 SER C 179 REMARK 465 SER C 180 REMARK 465 VAL C 181 REMARK 465 VAL C 182 REMARK 465 THR C 183 REMARK 465 VAL C 184 REMARK 465 PRO C 185 REMARK 465 SER C 186 REMARK 465 SER C 187 REMARK 465 SER C 188 REMARK 465 LEU C 189 REMARK 465 GLY C 190 REMARK 465 THR C 191 REMARK 465 GLN C 192 REMARK 465 THR C 193 REMARK 465 TYR C 194 REMARK 465 ILE C 195 REMARK 465 CYS C 196 REMARK 465 ASN C 197 REMARK 465 VAL C 198 REMARK 465 ASN C 199 REMARK 465 HIS C 200 REMARK 465 LYS C 201 REMARK 465 PRO C 202 REMARK 465 SER C 203 REMARK 465 ASN C 204 REMARK 465 THR C 205 REMARK 465 LYS C 206 REMARK 465 VAL C 207 REMARK 465 ASP C 208 REMARK 465 LYS C 209 REMARK 465 LYS C 210 REMARK 465 VAL C 211 REMARK 465 GLU C 212 REMARK 465 PRO C 213 REMARK 465 LYS C 214 REMARK 465 SER C 215 REMARK 465 CYS C 216 REMARK 465 ASP D 105 REMARK 465 LEU D 106 REMARK 465 LYS D 107 REMARK 465 ARG D 108 REMARK 465 THR D 109 REMARK 465 VAL D 110 REMARK 465 ALA D 111 REMARK 465 ALA D 112 REMARK 465 PRO D 113 REMARK 465 SER D 114 REMARK 465 VAL D 115 REMARK 465 PHE D 116 REMARK 465 ILE D 117 REMARK 465 PHE D 118 REMARK 465 PRO D 119 REMARK 465 PRO D 120 REMARK 465 SER D 121 REMARK 465 ASP D 122 REMARK 465 GLU D 123 REMARK 465 GLN D 124 REMARK 465 LEU D 125 REMARK 465 LYS D 126 REMARK 465 SER D 127 REMARK 465 GLY D 128 REMARK 465 THR D 129 REMARK 465 ALA D 130 REMARK 465 SER D 131 REMARK 465 VAL D 132 REMARK 465 VAL D 133 REMARK 465 CYS D 134 REMARK 465 LEU D 135 REMARK 465 LEU D 136 REMARK 465 ASN D 137 REMARK 465 ASN D 138 REMARK 465 PHE D 139 REMARK 465 TYR D 140 REMARK 465 PRO D 141 REMARK 465 ARG D 142 REMARK 465 GLU D 143 REMARK 465 ALA D 144 REMARK 465 LYS D 145 REMARK 465 VAL D 146 REMARK 465 GLN D 147 REMARK 465 TRP D 148 REMARK 465 LYS D 149 REMARK 465 VAL D 150 REMARK 465 ASP D 151 REMARK 465 ASN D 152 REMARK 465 ALA D 153 REMARK 465 LEU D 154 REMARK 465 GLN D 155 REMARK 465 SER D 156 REMARK 465 GLY D 157 REMARK 465 ASN D 158 REMARK 465 SER D 159 REMARK 465 GLN D 160 REMARK 465 GLU D 161 REMARK 465 SER D 162 REMARK 465 VAL D 163 REMARK 465 THR D 164 REMARK 465 GLU D 165 REMARK 465 GLN D 166 REMARK 465 ASP D 167 REMARK 465 SER D 168 REMARK 465 LYS D 169 REMARK 465 ASP D 170 REMARK 465 SER D 171 REMARK 465 THR D 172 REMARK 465 TYR D 173 REMARK 465 SER D 174 REMARK 465 LEU D 175 REMARK 465 SER D 176 REMARK 465 SER D 177 REMARK 465 THR D 178 REMARK 465 LEU D 179 REMARK 465 THR D 180 REMARK 465 LEU D 181 REMARK 465 SER D 182 REMARK 465 LYS D 183 REMARK 465 ALA D 184 REMARK 465 ASP D 185 REMARK 465 TYR D 186 REMARK 465 GLU D 187 REMARK 465 LYS D 188 REMARK 465 HIS D 189 REMARK 465 LYS D 190 REMARK 465 VAL D 191 REMARK 465 TYR D 192 REMARK 465 ALA D 193 REMARK 465 CYS D 194 REMARK 465 GLU D 195 REMARK 465 VAL D 196 REMARK 465 THR D 197 REMARK 465 HIS D 198 REMARK 465 GLN D 199 REMARK 465 GLY D 200 REMARK 465 LEU D 201 REMARK 465 SER D 202 REMARK 465 SER D 203 REMARK 465 PRO D 204 REMARK 465 VAL D 205 REMARK 465 THR D 206 REMARK 465 LYS D 207 REMARK 465 SER D 208 REMARK 465 PHE D 209 REMARK 465 ASN D 210 REMARK 465 ARG D 211 REMARK 465 GLY D 212 REMARK 465 GLU D 213 REMARK 465 CYS D 214 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 SER L 6 REMARK 465 GLN L 109 REMARK 465 PRO L 110 REMARK 465 LYS L 111 REMARK 465 ALA L 112 REMARK 465 ALA L 113 REMARK 465 PRO L 114 REMARK 465 SER L 115 REMARK 465 VAL L 116 REMARK 465 THR L 117 REMARK 465 LEU L 118 REMARK 465 PHE L 119 REMARK 465 PRO L 120 REMARK 465 PRO L 121 REMARK 465 SER L 122 REMARK 465 SER L 123 REMARK 465 GLU L 124 REMARK 465 GLU L 125 REMARK 465 LEU L 126 REMARK 465 GLN L 127 REMARK 465 ALA L 128 REMARK 465 ASN L 129 REMARK 465 LYS L 130 REMARK 465 ALA L 131 REMARK 465 THR L 132 REMARK 465 LEU L 133 REMARK 465 VAL L 134 REMARK 465 CYS L 135 REMARK 465 LEU L 136 REMARK 465 ILE L 137 REMARK 465 SER L 138 REMARK 465 ASP L 139 REMARK 465 PHE L 140 REMARK 465 TYR L 141 REMARK 465 PRO L 142 REMARK 465 GLY L 143 REMARK 465 ALA L 144 REMARK 465 VAL L 145 REMARK 465 THR L 146 REMARK 465 VAL L 147 REMARK 465 ALA L 148 REMARK 465 TRP L 149 REMARK 465 LYS L 150 REMARK 465 ALA L 151 REMARK 465 ASP L 152 REMARK 465 SER L 153 REMARK 465 SER L 154 REMARK 465 PRO L 155 REMARK 465 VAL L 156 REMARK 465 LYS L 157 REMARK 465 ALA L 158 REMARK 465 GLY L 159 REMARK 465 VAL L 160 REMARK 465 GLU L 161 REMARK 465 THR L 162 REMARK 465 THR L 163 REMARK 465 THR L 164 REMARK 465 PRO L 165 REMARK 465 SER L 166 REMARK 465 LYS L 167 REMARK 465 GLN L 168 REMARK 465 SER L 169 REMARK 465 ASN L 170 REMARK 465 ASN L 171 REMARK 465 LYS L 172 REMARK 465 TYR L 173 REMARK 465 ALA L 174 REMARK 465 ALA L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 TYR L 178 REMARK 465 LEU L 179 REMARK 465 SER L 180 REMARK 465 LEU L 181 REMARK 465 THR L 182 REMARK 465 PRO L 183 REMARK 465 GLU L 184 REMARK 465 GLN L 185 REMARK 465 TRP L 186 REMARK 465 LYS L 187 REMARK 465 SER L 188 REMARK 465 HIS L 189 REMARK 465 ARG L 190 REMARK 465 SER L 191 REMARK 465 TYR L 192 REMARK 465 SER L 193 REMARK 465 CYS L 194 REMARK 465 GLN L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLU L 199 REMARK 465 GLY L 200 REMARK 465 SER L 201 REMARK 465 THR L 202 REMARK 465 VAL L 203 REMARK 465 GLU L 204 REMARK 465 LYS L 205 REMARK 465 THR L 206 REMARK 465 VAL L 207 REMARK 465 ALA L 208 REMARK 465 PRO L 209 REMARK 465 THR L 210 REMARK 465 GLU L 211 REMARK 465 CYS L 212 REMARK 465 SER L 213 REMARK 465 ALA A 31 REMARK 465 GLU A 32 REMARK 465 TYR A 61 REMARK 465 GLU A 62 REMARK 465 THR A 63 REMARK 465 GLU A 64 REMARK 465 ASP A 148 REMARK 465 ASP A 149 REMARK 465 GLU A 185A REMARK 465 ASN A 185B REMARK 465 GLN A 185C REMARK 465 GLY A 185D REMARK 465 ASN A 185E REMARK 465 ARG A 185F REMARK 465 SER A 185G REMARK 465 ASN A 185H REMARK 465 ASN A 185I REMARK 465 SER A 185J REMARK 465 ASN A 185K REMARK 465 THR A 400 REMARK 465 SER A 401 REMARK 465 VAL A 402 REMARK 465 GLN A 403 REMARK 465 GLY A 404 REMARK 465 SER A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 THR A 408 REMARK 465 GLY A 409 REMARK 465 SER A 410 REMARK 465 VAL A 506 REMARK 465 GLY A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 ALA E 512 REMARK 465 VAL E 513 REMARK 465 GLY E 514 REMARK 465 ILE E 515 REMARK 465 GLY E 516 REMARK 465 ALA E 517 REMARK 465 VAL E 518 REMARK 465 PHE E 519 REMARK 465 GLY E 547 REMARK 465 ILE E 548 REMARK 465 VAL E 549 REMARK 465 GLN E 550 REMARK 465 GLN E 551 REMARK 465 GLN E 552 REMARK 465 SER E 553 REMARK 465 ASN E 554 REMARK 465 LEU E 555 REMARK 465 LEU E 556 REMARK 465 ARG E 557 REMARK 465 ALA E 558 REMARK 465 PRO E 559 REMARK 465 ASP E 659 REMARK 465 LEU E 660 REMARK 465 LEU E 661 REMARK 465 ALA E 662 REMARK 465 LEU E 663 REMARK 465 ASP E 664 REMARK 465 SER F 112 REMARK 465 SER F 113 REMARK 465 ALA F 114 REMARK 465 SER F 115 REMARK 465 THR F 116 REMARK 465 LYS F 117 REMARK 465 GLY F 118 REMARK 465 PRO F 119 REMARK 465 SER F 120 REMARK 465 VAL F 121 REMARK 465 PHE F 122 REMARK 465 PRO F 123 REMARK 465 LEU F 124 REMARK 465 ALA F 125 REMARK 465 PRO F 126 REMARK 465 SER F 127 REMARK 465 SER F 128 REMARK 465 LYS F 129 REMARK 465 SER F 130 REMARK 465 THR F 131 REMARK 465 SER F 132 REMARK 465 GLY F 133 REMARK 465 GLY F 134 REMARK 465 THR F 135 REMARK 465 ALA F 136 REMARK 465 ALA F 137 REMARK 465 LEU F 138 REMARK 465 GLY F 139 REMARK 465 CYS F 140 REMARK 465 LEU F 141 REMARK 465 VAL F 142 REMARK 465 LYS F 143 REMARK 465 ASP F 144 REMARK 465 TYR F 145 REMARK 465 PHE F 146 REMARK 465 PRO F 147 REMARK 465 GLU F 148 REMARK 465 PRO F 149 REMARK 465 VAL F 150 REMARK 465 THR F 151 REMARK 465 VAL F 152 REMARK 465 SER F 153 REMARK 465 TRP F 154 REMARK 465 ASN F 155 REMARK 465 SER F 156 REMARK 465 GLY F 157 REMARK 465 ALA F 158 REMARK 465 LEU F 159 REMARK 465 THR F 160 REMARK 465 SER F 161 REMARK 465 GLY F 162 REMARK 465 VAL F 163 REMARK 465 HIS F 164 REMARK 465 THR F 165 REMARK 465 PHE F 166 REMARK 465 PRO F 167 REMARK 465 ALA F 168 REMARK 465 VAL F 169 REMARK 465 LEU F 170 REMARK 465 GLN F 171 REMARK 465 SER F 172 REMARK 465 SER F 173 REMARK 465 GLY F 174 REMARK 465 LEU F 175 REMARK 465 TYR F 176 REMARK 465 SER F 177 REMARK 465 LEU F 178 REMARK 465 SER F 179 REMARK 465 SER F 180 REMARK 465 VAL F 181 REMARK 465 VAL F 182 REMARK 465 THR F 183 REMARK 465 VAL F 184 REMARK 465 PRO F 185 REMARK 465 SER F 186 REMARK 465 SER F 187 REMARK 465 SER F 188 REMARK 465 LEU F 189 REMARK 465 GLY F 190 REMARK 465 THR F 191 REMARK 465 GLN F 192 REMARK 465 THR F 193 REMARK 465 TYR F 194 REMARK 465 ILE F 195 REMARK 465 CYS F 196 REMARK 465 ASN F 197 REMARK 465 VAL F 198 REMARK 465 ASN F 199 REMARK 465 HIS F 200 REMARK 465 LYS F 201 REMARK 465 PRO F 202 REMARK 465 SER F 203 REMARK 465 ASN F 204 REMARK 465 THR F 205 REMARK 465 LYS F 206 REMARK 465 VAL F 207 REMARK 465 ASP F 208 REMARK 465 LYS F 209 REMARK 465 LYS F 210 REMARK 465 VAL F 211 REMARK 465 GLU F 212 REMARK 465 PRO F 213 REMARK 465 LYS F 214 REMARK 465 SER F 215 REMARK 465 CYS F 216 REMARK 465 ASP I 105 REMARK 465 LEU I 106 REMARK 465 LYS I 107 REMARK 465 ARG I 108 REMARK 465 THR I 109 REMARK 465 VAL I 110 REMARK 465 ALA I 111 REMARK 465 ALA I 112 REMARK 465 PRO I 113 REMARK 465 SER I 114 REMARK 465 VAL I 115 REMARK 465 PHE I 116 REMARK 465 ILE I 117 REMARK 465 PHE I 118 REMARK 465 PRO I 119 REMARK 465 PRO I 120 REMARK 465 SER I 121 REMARK 465 ASP I 122 REMARK 465 GLU I 123 REMARK 465 GLN I 124 REMARK 465 LEU I 125 REMARK 465 LYS I 126 REMARK 465 SER I 127 REMARK 465 GLY I 128 REMARK 465 THR I 129 REMARK 465 ALA I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 VAL I 133 REMARK 465 CYS I 134 REMARK 465 LEU I 135 REMARK 465 LEU I 136 REMARK 465 ASN I 137 REMARK 465 ASN I 138 REMARK 465 PHE I 139 REMARK 465 TYR I 140 REMARK 465 PRO I 141 REMARK 465 ARG I 142 REMARK 465 GLU I 143 REMARK 465 ALA I 144 REMARK 465 LYS I 145 REMARK 465 VAL I 146 REMARK 465 GLN I 147 REMARK 465 TRP I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 ASP I 151 REMARK 465 ASN I 152 REMARK 465 ALA I 153 REMARK 465 LEU I 154 REMARK 465 GLN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLN I 160 REMARK 465 GLU I 161 REMARK 465 SER I 162 REMARK 465 VAL I 163 REMARK 465 THR I 164 REMARK 465 GLU I 165 REMARK 465 GLN I 166 REMARK 465 ASP I 167 REMARK 465 SER I 168 REMARK 465 LYS I 169 REMARK 465 ASP I 170 REMARK 465 SER I 171 REMARK 465 THR I 172 REMARK 465 TYR I 173 REMARK 465 SER I 174 REMARK 465 LEU I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 THR I 178 REMARK 465 LEU I 179 REMARK 465 THR I 180 REMARK 465 LEU I 181 REMARK 465 SER I 182 REMARK 465 LYS I 183 REMARK 465 ALA I 184 REMARK 465 ASP I 185 REMARK 465 TYR I 186 REMARK 465 GLU I 187 REMARK 465 LYS I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 VAL I 191 REMARK 465 TYR I 192 REMARK 465 ALA I 193 REMARK 465 CYS I 194 REMARK 465 GLU I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLN I 199 REMARK 465 GLY I 200 REMARK 465 LEU I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 PRO I 204 REMARK 465 VAL I 205 REMARK 465 THR I 206 REMARK 465 LYS I 207 REMARK 465 SER I 208 REMARK 465 PHE I 209 REMARK 465 ASN I 210 REMARK 465 ARG I 211 REMARK 465 GLY I 212 REMARK 465 GLU I 213 REMARK 465 CYS I 214 REMARK 465 SER J 115 REMARK 465 THR J 116 REMARK 465 LYS J 117 REMARK 465 GLY J 118 REMARK 465 PRO J 119 REMARK 465 SER J 120 REMARK 465 VAL J 121 REMARK 465 PHE J 122 REMARK 465 PRO J 123 REMARK 465 LEU J 124 REMARK 465 ALA J 125 REMARK 465 PRO J 126 REMARK 465 SER J 127 REMARK 465 SER J 128 REMARK 465 LYS J 129 REMARK 465 SER J 130 REMARK 465 THR J 131 REMARK 465 SER J 132 REMARK 465 GLY J 133 REMARK 465 GLY J 134 REMARK 465 THR J 135 REMARK 465 ALA J 136 REMARK 465 ALA J 137 REMARK 465 LEU J 138 REMARK 465 GLY J 139 REMARK 465 CYS J 140 REMARK 465 LEU J 141 REMARK 465 VAL J 142 REMARK 465 LYS J 143 REMARK 465 ASP J 144 REMARK 465 TYR J 145 REMARK 465 PHE J 146 REMARK 465 PRO J 147 REMARK 465 GLU J 148 REMARK 465 PRO J 149 REMARK 465 VAL J 150 REMARK 465 THR J 151 REMARK 465 VAL J 152 REMARK 465 SER J 153 REMARK 465 TRP J 154 REMARK 465 ASN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ALA J 158 REMARK 465 LEU J 159 REMARK 465 THR J 160 REMARK 465 SER J 161 REMARK 465 GLY J 162 REMARK 465 VAL J 163 REMARK 465 HIS J 164 REMARK 465 THR J 165 REMARK 465 PHE J 166 REMARK 465 PRO J 167 REMARK 465 ALA J 168 REMARK 465 VAL J 169 REMARK 465 LEU J 170 REMARK 465 GLN J 171 REMARK 465 SER J 172 REMARK 465 SER J 173 REMARK 465 GLY J 174 REMARK 465 LEU J 175 REMARK 465 TYR J 176 REMARK 465 SER J 177 REMARK 465 LEU J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 VAL J 181 REMARK 465 VAL J 182 REMARK 465 THR J 183 REMARK 465 VAL J 184 REMARK 465 PRO J 185 REMARK 465 SER J 186 REMARK 465 SER J 187 REMARK 465 SER J 188 REMARK 465 LEU J 189 REMARK 465 GLY J 190 REMARK 465 THR J 191 REMARK 465 GLN J 192 REMARK 465 THR J 193 REMARK 465 TYR J 194 REMARK 465 ILE J 195 REMARK 465 CYS J 196 REMARK 465 ASN J 197 REMARK 465 VAL J 198 REMARK 465 ASN J 199 REMARK 465 HIS J 200 REMARK 465 LYS J 201 REMARK 465 PRO J 202 REMARK 465 SER J 203 REMARK 465 ASN J 204 REMARK 465 THR J 205 REMARK 465 LYS J 206 REMARK 465 VAL J 207 REMARK 465 ASP J 208 REMARK 465 LYS J 209 REMARK 465 ARG J 210 REMARK 465 VAL J 211 REMARK 465 GLU J 212 REMARK 465 PRO J 213 REMARK 465 LYS J 214 REMARK 465 SER J 215 REMARK 465 CYS J 216 REMARK 465 SER K 6 REMARK 465 GLN K 109 REMARK 465 PRO K 110 REMARK 465 LYS K 111 REMARK 465 ALA K 112 REMARK 465 ALA K 113 REMARK 465 PRO K 114 REMARK 465 SER K 115 REMARK 465 VAL K 116 REMARK 465 THR K 117 REMARK 465 LEU K 118 REMARK 465 PHE K 119 REMARK 465 PRO K 120 REMARK 465 PRO K 121 REMARK 465 SER K 122 REMARK 465 SER K 123 REMARK 465 GLU K 124 REMARK 465 GLU K 125 REMARK 465 LEU K 126 REMARK 465 GLN K 127 REMARK 465 ALA K 128 REMARK 465 ASN K 129 REMARK 465 LYS K 130 REMARK 465 ALA K 131 REMARK 465 THR K 132 REMARK 465 LEU K 133 REMARK 465 VAL K 134 REMARK 465 CYS K 135 REMARK 465 LEU K 136 REMARK 465 ILE K 137 REMARK 465 SER K 138 REMARK 465 ASP K 139 REMARK 465 PHE K 140 REMARK 465 TYR K 141 REMARK 465 PRO K 142 REMARK 465 GLY K 143 REMARK 465 ALA K 144 REMARK 465 VAL K 145 REMARK 465 THR K 146 REMARK 465 VAL K 147 REMARK 465 ALA K 148 REMARK 465 TRP K 149 REMARK 465 LYS K 150 REMARK 465 ALA K 151 REMARK 465 ASP K 152 REMARK 465 SER K 153 REMARK 465 SER K 154 REMARK 465 PRO K 155 REMARK 465 VAL K 156 REMARK 465 LYS K 157 REMARK 465 ALA K 158 REMARK 465 GLY K 159 REMARK 465 VAL K 160 REMARK 465 GLU K 161 REMARK 465 THR K 162 REMARK 465 THR K 163 REMARK 465 THR K 164 REMARK 465 PRO K 165 REMARK 465 SER K 166 REMARK 465 LYS K 167 REMARK 465 GLN K 168 REMARK 465 SER K 169 REMARK 465 ASN K 170 REMARK 465 ASN K 171 REMARK 465 LYS K 172 REMARK 465 TYR K 173 REMARK 465 ALA K 174 REMARK 465 ALA K 175 REMARK 465 SER K 176 REMARK 465 SER K 177 REMARK 465 TYR K 178 REMARK 465 LEU K 179 REMARK 465 SER K 180 REMARK 465 LEU K 181 REMARK 465 THR K 182 REMARK 465 PRO K 183 REMARK 465 GLU K 184 REMARK 465 GLN K 185 REMARK 465 TRP K 186 REMARK 465 LYS K 187 REMARK 465 SER K 188 REMARK 465 HIS K 189 REMARK 465 ARG K 190 REMARK 465 SER K 191 REMARK 465 TYR K 192 REMARK 465 SER K 193 REMARK 465 CYS K 194 REMARK 465 GLN K 195 REMARK 465 VAL K 196 REMARK 465 THR K 197 REMARK 465 HIS K 198 REMARK 465 GLU K 199 REMARK 465 GLY K 200 REMARK 465 SER K 201 REMARK 465 THR K 202 REMARK 465 VAL K 203 REMARK 465 GLU K 204 REMARK 465 LYS K 205 REMARK 465 THR K 206 REMARK 465 VAL K 207 REMARK 465 ALA K 208 REMARK 465 PRO K 209 REMARK 465 THR K 210 REMARK 465 GLU K 211 REMARK 465 CYS K 212 REMARK 465 SER K 213 REMARK 465 ALA M 31 REMARK 465 GLU M 32 REMARK 465 TYR M 61 REMARK 465 GLU M 62 REMARK 465 THR M 63 REMARK 465 GLU M 64 REMARK 465 ASP M 148 REMARK 465 ASP M 149 REMARK 465 GLU M 185A REMARK 465 ASN M 185B REMARK 465 GLN M 185C REMARK 465 GLY M 185D REMARK 465 ASN M 185E REMARK 465 ARG M 185F REMARK 465 SER M 185G REMARK 465 ASN M 185H REMARK 465 ASN M 185I REMARK 465 SER M 185J REMARK 465 ASN M 185K REMARK 465 THR M 400 REMARK 465 SER M 401 REMARK 465 VAL M 402 REMARK 465 GLN M 403 REMARK 465 GLY M 404 REMARK 465 SER M 405 REMARK 465 ASN M 406 REMARK 465 SER M 407 REMARK 465 THR M 408 REMARK 465 GLY M 409 REMARK 465 SER M 410 REMARK 465 VAL M 506 REMARK 465 GLY M 507 REMARK 465 ARG M 508 REMARK 465 ARG M 509 REMARK 465 ARG M 510 REMARK 465 ARG M 511 REMARK 465 ARG M 512 REMARK 465 ARG M 513 REMARK 465 ALA N 512 REMARK 465 VAL N 513 REMARK 465 GLY N 514 REMARK 465 ILE N 515 REMARK 465 GLY N 516 REMARK 465 ALA N 517 REMARK 465 VAL N 518 REMARK 465 PHE N 519 REMARK 465 GLY N 547 REMARK 465 ILE N 548 REMARK 465 VAL N 549 REMARK 465 GLN N 550 REMARK 465 GLN N 551 REMARK 465 GLN N 552 REMARK 465 SER N 553 REMARK 465 ASN N 554 REMARK 465 LEU N 555 REMARK 465 LEU N 556 REMARK 465 ARG N 557 REMARK 465 ALA N 558 REMARK 465 PRO N 559 REMARK 465 ASP N 659 REMARK 465 LEU N 660 REMARK 465 LEU N 661 REMARK 465 ALA N 662 REMARK 465 LEU N 663 REMARK 465 ASP N 664 REMARK 465 SER O 112 REMARK 465 SER O 113 REMARK 465 ALA O 114 REMARK 465 SER O 115 REMARK 465 THR O 116 REMARK 465 LYS O 117 REMARK 465 GLY O 118 REMARK 465 PRO O 119 REMARK 465 SER O 120 REMARK 465 VAL O 121 REMARK 465 PHE O 122 REMARK 465 PRO O 123 REMARK 465 LEU O 124 REMARK 465 ALA O 125 REMARK 465 PRO O 126 REMARK 465 SER O 127 REMARK 465 SER O 128 REMARK 465 LYS O 129 REMARK 465 SER O 130 REMARK 465 THR O 131 REMARK 465 SER O 132 REMARK 465 GLY O 133 REMARK 465 GLY O 134 REMARK 465 THR O 135 REMARK 465 ALA O 136 REMARK 465 ALA O 137 REMARK 465 LEU O 138 REMARK 465 GLY O 139 REMARK 465 CYS O 140 REMARK 465 LEU O 141 REMARK 465 VAL O 142 REMARK 465 LYS O 143 REMARK 465 ASP O 144 REMARK 465 TYR O 145 REMARK 465 PHE O 146 REMARK 465 PRO O 147 REMARK 465 GLU O 148 REMARK 465 PRO O 149 REMARK 465 VAL O 150 REMARK 465 THR O 151 REMARK 465 VAL O 152 REMARK 465 SER O 153 REMARK 465 TRP O 154 REMARK 465 ASN O 155 REMARK 465 SER O 156 REMARK 465 GLY O 157 REMARK 465 ALA O 158 REMARK 465 LEU O 159 REMARK 465 THR O 160 REMARK 465 SER O 161 REMARK 465 GLY O 162 REMARK 465 VAL O 163 REMARK 465 HIS O 164 REMARK 465 THR O 165 REMARK 465 PHE O 166 REMARK 465 PRO O 167 REMARK 465 ALA O 168 REMARK 465 VAL O 169 REMARK 465 LEU O 170 REMARK 465 GLN O 171 REMARK 465 SER O 172 REMARK 465 SER O 173 REMARK 465 GLY O 174 REMARK 465 LEU O 175 REMARK 465 TYR O 176 REMARK 465 SER O 177 REMARK 465 LEU O 178 REMARK 465 SER O 179 REMARK 465 SER O 180 REMARK 465 VAL O 181 REMARK 465 VAL O 182 REMARK 465 THR O 183 REMARK 465 VAL O 184 REMARK 465 PRO O 185 REMARK 465 SER O 186 REMARK 465 SER O 187 REMARK 465 SER O 188 REMARK 465 LEU O 189 REMARK 465 GLY O 190 REMARK 465 THR O 191 REMARK 465 GLN O 192 REMARK 465 THR O 193 REMARK 465 TYR O 194 REMARK 465 ILE O 195 REMARK 465 CYS O 196 REMARK 465 ASN O 197 REMARK 465 VAL O 198 REMARK 465 ASN O 199 REMARK 465 HIS O 200 REMARK 465 LYS O 201 REMARK 465 PRO O 202 REMARK 465 SER O 203 REMARK 465 ASN O 204 REMARK 465 THR O 205 REMARK 465 LYS O 206 REMARK 465 VAL O 207 REMARK 465 ASP O 208 REMARK 465 LYS O 209 REMARK 465 LYS O 210 REMARK 465 VAL O 211 REMARK 465 GLU O 212 REMARK 465 PRO O 213 REMARK 465 LYS O 214 REMARK 465 SER O 215 REMARK 465 CYS O 216 REMARK 465 ASP P 105 REMARK 465 LEU P 106 REMARK 465 LYS P 107 REMARK 465 ARG P 108 REMARK 465 THR P 109 REMARK 465 VAL P 110 REMARK 465 ALA P 111 REMARK 465 ALA P 112 REMARK 465 PRO P 113 REMARK 465 SER P 114 REMARK 465 VAL P 115 REMARK 465 PHE P 116 REMARK 465 ILE P 117 REMARK 465 PHE P 118 REMARK 465 PRO P 119 REMARK 465 PRO P 120 REMARK 465 SER P 121 REMARK 465 ASP P 122 REMARK 465 GLU P 123 REMARK 465 GLN P 124 REMARK 465 LEU P 125 REMARK 465 LYS P 126 REMARK 465 SER P 127 REMARK 465 GLY P 128 REMARK 465 THR P 129 REMARK 465 ALA P 130 REMARK 465 SER P 131 REMARK 465 VAL P 132 REMARK 465 VAL P 133 REMARK 465 CYS P 134 REMARK 465 LEU P 135 REMARK 465 LEU P 136 REMARK 465 ASN P 137 REMARK 465 ASN P 138 REMARK 465 PHE P 139 REMARK 465 TYR P 140 REMARK 465 PRO P 141 REMARK 465 ARG P 142 REMARK 465 GLU P 143 REMARK 465 ALA P 144 REMARK 465 LYS P 145 REMARK 465 VAL P 146 REMARK 465 GLN P 147 REMARK 465 TRP P 148 REMARK 465 LYS P 149 REMARK 465 VAL P 150 REMARK 465 ASP P 151 REMARK 465 ASN P 152 REMARK 465 ALA P 153 REMARK 465 LEU P 154 REMARK 465 GLN P 155 REMARK 465 SER P 156 REMARK 465 GLY P 157 REMARK 465 ASN P 158 REMARK 465 SER P 159 REMARK 465 GLN P 160 REMARK 465 GLU P 161 REMARK 465 SER P 162 REMARK 465 VAL P 163 REMARK 465 THR P 164 REMARK 465 GLU P 165 REMARK 465 GLN P 166 REMARK 465 ASP P 167 REMARK 465 SER P 168 REMARK 465 LYS P 169 REMARK 465 ASP P 170 REMARK 465 SER P 171 REMARK 465 THR P 172 REMARK 465 TYR P 173 REMARK 465 SER P 174 REMARK 465 LEU P 175 REMARK 465 SER P 176 REMARK 465 SER P 177 REMARK 465 THR P 178 REMARK 465 LEU P 179 REMARK 465 THR P 180 REMARK 465 LEU P 181 REMARK 465 SER P 182 REMARK 465 LYS P 183 REMARK 465 ALA P 184 REMARK 465 ASP P 185 REMARK 465 TYR P 186 REMARK 465 GLU P 187 REMARK 465 LYS P 188 REMARK 465 HIS P 189 REMARK 465 LYS P 190 REMARK 465 VAL P 191 REMARK 465 TYR P 192 REMARK 465 ALA P 193 REMARK 465 CYS P 194 REMARK 465 GLU P 195 REMARK 465 VAL P 196 REMARK 465 THR P 197 REMARK 465 HIS P 198 REMARK 465 GLN P 199 REMARK 465 GLY P 200 REMARK 465 LEU P 201 REMARK 465 SER P 202 REMARK 465 SER P 203 REMARK 465 PRO P 204 REMARK 465 VAL P 205 REMARK 465 THR P 206 REMARK 465 LYS P 207 REMARK 465 SER P 208 REMARK 465 PHE P 209 REMARK 465 ASN P 210 REMARK 465 ARG P 211 REMARK 465 GLY P 212 REMARK 465 GLU P 213 REMARK 465 CYS P 214 REMARK 465 SER Q 115 REMARK 465 THR Q 116 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 LYS Q 129 REMARK 465 SER Q 130 REMARK 465 THR Q 131 REMARK 465 SER Q 132 REMARK 465 GLY Q 133 REMARK 465 GLY Q 134 REMARK 465 THR Q 135 REMARK 465 ALA Q 136 REMARK 465 ALA Q 137 REMARK 465 LEU Q 138 REMARK 465 GLY Q 139 REMARK 465 CYS Q 140 REMARK 465 LEU Q 141 REMARK 465 VAL Q 142 REMARK 465 LYS Q 143 REMARK 465 ASP Q 144 REMARK 465 TYR Q 145 REMARK 465 PHE Q 146 REMARK 465 PRO Q 147 REMARK 465 GLU Q 148 REMARK 465 PRO Q 149 REMARK 465 VAL Q 150 REMARK 465 THR Q 151 REMARK 465 VAL Q 152 REMARK 465 SER Q 153 REMARK 465 TRP Q 154 REMARK 465 ASN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ALA Q 158 REMARK 465 LEU Q 159 REMARK 465 THR Q 160 REMARK 465 SER Q 161 REMARK 465 GLY Q 162 REMARK 465 VAL Q 163 REMARK 465 HIS Q 164 REMARK 465 THR Q 165 REMARK 465 PHE Q 166 REMARK 465 PRO Q 167 REMARK 465 ALA Q 168 REMARK 465 VAL Q 169 REMARK 465 LEU Q 170 REMARK 465 GLN Q 171 REMARK 465 SER Q 172 REMARK 465 SER Q 173 REMARK 465 GLY Q 174 REMARK 465 LEU Q 175 REMARK 465 TYR Q 176 REMARK 465 SER Q 177 REMARK 465 LEU Q 178 REMARK 465 SER Q 179 REMARK 465 SER Q 180 REMARK 465 VAL Q 181 REMARK 465 VAL Q 182 REMARK 465 THR Q 183 REMARK 465 VAL Q 184 REMARK 465 PRO Q 185 REMARK 465 SER Q 186 REMARK 465 SER Q 187 REMARK 465 SER Q 188 REMARK 465 LEU Q 189 REMARK 465 GLY Q 190 REMARK 465 THR Q 191 REMARK 465 GLN Q 192 REMARK 465 THR Q 193 REMARK 465 TYR Q 194 REMARK 465 ILE Q 195 REMARK 465 CYS Q 196 REMARK 465 ASN Q 197 REMARK 465 VAL Q 198 REMARK 465 ASN Q 199 REMARK 465 HIS Q 200 REMARK 465 LYS Q 201 REMARK 465 PRO Q 202 REMARK 465 SER Q 203 REMARK 465 ASN Q 204 REMARK 465 THR Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 ASP Q 208 REMARK 465 LYS Q 209 REMARK 465 ARG Q 210 REMARK 465 VAL Q 211 REMARK 465 GLU Q 212 REMARK 465 PRO Q 213 REMARK 465 LYS Q 214 REMARK 465 SER Q 215 REMARK 465 CYS Q 216 REMARK 465 SER R 6 REMARK 465 GLN R 109 REMARK 465 PRO R 110 REMARK 465 LYS R 111 REMARK 465 ALA R 112 REMARK 465 ALA R 113 REMARK 465 PRO R 114 REMARK 465 SER R 115 REMARK 465 VAL R 116 REMARK 465 THR R 117 REMARK 465 LEU R 118 REMARK 465 PHE R 119 REMARK 465 PRO R 120 REMARK 465 PRO R 121 REMARK 465 SER R 122 REMARK 465 SER R 123 REMARK 465 GLU R 124 REMARK 465 GLU R 125 REMARK 465 LEU R 126 REMARK 465 GLN R 127 REMARK 465 ALA R 128 REMARK 465 ASN R 129 REMARK 465 LYS R 130 REMARK 465 ALA R 131 REMARK 465 THR R 132 REMARK 465 LEU R 133 REMARK 465 VAL R 134 REMARK 465 CYS R 135 REMARK 465 LEU R 136 REMARK 465 ILE R 137 REMARK 465 SER R 138 REMARK 465 ASP R 139 REMARK 465 PHE R 140 REMARK 465 TYR R 141 REMARK 465 PRO R 142 REMARK 465 GLY R 143 REMARK 465 ALA R 144 REMARK 465 VAL R 145 REMARK 465 THR R 146 REMARK 465 VAL R 147 REMARK 465 ALA R 148 REMARK 465 TRP R 149 REMARK 465 LYS R 150 REMARK 465 ALA R 151 REMARK 465 ASP R 152 REMARK 465 SER R 153 REMARK 465 SER R 154 REMARK 465 PRO R 155 REMARK 465 VAL R 156 REMARK 465 LYS R 157 REMARK 465 ALA R 158 REMARK 465 GLY R 159 REMARK 465 VAL R 160 REMARK 465 GLU R 161 REMARK 465 THR R 162 REMARK 465 THR R 163 REMARK 465 THR R 164 REMARK 465 PRO R 165 REMARK 465 SER R 166 REMARK 465 LYS R 167 REMARK 465 GLN R 168 REMARK 465 SER R 169 REMARK 465 ASN R 170 REMARK 465 ASN R 171 REMARK 465 LYS R 172 REMARK 465 TYR R 173 REMARK 465 ALA R 174 REMARK 465 ALA R 175 REMARK 465 SER R 176 REMARK 465 SER R 177 REMARK 465 TYR R 178 REMARK 465 LEU R 179 REMARK 465 SER R 180 REMARK 465 LEU R 181 REMARK 465 THR R 182 REMARK 465 PRO R 183 REMARK 465 GLU R 184 REMARK 465 GLN R 185 REMARK 465 TRP R 186 REMARK 465 LYS R 187 REMARK 465 SER R 188 REMARK 465 HIS R 189 REMARK 465 ARG R 190 REMARK 465 SER R 191 REMARK 465 TYR R 192 REMARK 465 SER R 193 REMARK 465 CYS R 194 REMARK 465 GLN R 195 REMARK 465 VAL R 196 REMARK 465 THR R 197 REMARK 465 HIS R 198 REMARK 465 GLU R 199 REMARK 465 GLY R 200 REMARK 465 SER R 201 REMARK 465 THR R 202 REMARK 465 VAL R 203 REMARK 465 GLU R 204 REMARK 465 LYS R 205 REMARK 465 THR R 206 REMARK 465 VAL R 207 REMARK 465 ALA R 208 REMARK 465 PRO R 209 REMARK 465 THR R 210 REMARK 465 GLU R 211 REMARK 465 CYS R 212 REMARK 465 SER R 213 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ARG G 151 CG CD NE CZ NH1 NH2 REMARK 470 ARG A 151 CG CD NE CZ NH1 NH2 REMARK 470 ARG M 151 CG CD NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 O2 MAN Z 5 C2 MAN Z 6 1.60 REMARK 500 O2 MAN p 5 C2 MAN p 6 1.60 REMARK 500 O2 MAN h 5 C2 MAN h 6 1.60 REMARK 500 O3 MAN h 7 O5 MAN h 8 1.81 REMARK 500 O3 MAN p 7 O5 MAN p 8 1.81 REMARK 500 O3 MAN Z 7 O5 MAN Z 8 1.81 REMARK 500 O6 BMA f 3 C2 MAN f 4 1.85 REMARK 500 O6 BMA X 3 C2 MAN X 4 1.85 REMARK 500 O6 BMA n 3 C2 MAN n 4 1.85 REMARK 500 O4 NAG h 2 O5 BMA h 3 1.91 REMARK 500 O4 NAG p 2 O5 BMA p 3 1.91 REMARK 500 O4 NAG Z 2 O5 BMA Z 3 1.91 REMARK 500 O3 BMA h 3 C2 MAN h 4 1.94 REMARK 500 O3 BMA p 3 C2 MAN p 4 1.94 REMARK 500 O3 BMA Z 3 C2 MAN Z 4 1.95 REMARK 500 O2 MAN Z 4 C2 MAN Z 5 1.98 REMARK 500 O2 MAN h 4 C2 MAN h 5 1.98 REMARK 500 O2 MAN p 4 C2 MAN p 5 1.98 REMARK 500 O6 BMA V 3 O5 MAN V 6 2.02 REMARK 500 O6 BMA d 3 O5 MAN d 6 2.02 REMARK 500 O6 BMA l 3 O5 MAN l 6 2.02 REMARK 500 O6 MAN p 7 O5 MAN p 9 2.09 REMARK 500 O6 MAN h 7 O5 MAN h 9 2.09 REMARK 500 O6 MAN Z 7 O5 MAN Z 9 2.09 REMARK 500 O4 NAG h 1 O5 NAG h 2 2.12 REMARK 500 O4 NAG Z 1 O5 NAG Z 2 2.12 REMARK 500 O4 NAG p 1 O5 NAG p 2 2.12 REMARK 500 O6 BMA p 3 C2 MAN p 7 2.14 REMARK 500 O6 BMA h 3 C2 MAN h 7 2.14 REMARK 500 O6 BMA Z 3 C2 MAN Z 7 2.14 REMARK 500 C6 BMA Z 3 C1 MAN Z 7 2.14 REMARK 500 C6 BMA p 3 C1 MAN p 7 2.14 REMARK 500 C6 BMA h 3 C1 MAN h 7 2.14 REMARK 500 C3 BMA Z 3 C1 MAN Z 4 2.17 REMARK 500 C3 BMA p 3 C1 MAN p 4 2.17 REMARK 500 C3 BMA h 3 C1 MAN h 4 2.17 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 THR G 71 48.47 -92.45 REMARK 500 LEU G 122 54.36 -94.74 REMARK 500 ARG G 166 49.65 -84.14 REMARK 500 ASN G 195 -67.57 -97.83 REMARK 500 CYS G 196 18.09 49.68 REMARK 500 PHE G 353 -167.81 -126.18 REMARK 500 ILE G 430 -71.82 -122.34 REMARK 500 SER G 463 -2.09 65.23 REMARK 500 ASN B 616 58.58 -94.80 REMARK 500 PRO H 84 67.21 -69.86 REMARK 500 ALA H 85 14.81 -140.46 REMARK 500 LEU L 28 57.36 -94.39 REMARK 500 ASN L 51 -11.13 71.70 REMARK 500 GLN L 52 -14.57 -140.61 REMARK 500 ARG L 61 -36.31 -130.80 REMARK 500 ASN L 66C 70.34 56.16 REMARK 500 ASP L 82 31.53 -98.21 REMARK 500 THR A 71 48.63 -92.54 REMARK 500 LEU A 122 54.30 -94.74 REMARK 500 ARG A 166 49.69 -84.12 REMARK 500 ASN A 195 -67.55 -97.80 REMARK 500 CYS A 196 18.01 49.72 REMARK 500 PHE A 353 -167.82 -126.19 REMARK 500 ILE A 430 -71.74 -122.35 REMARK 500 SER A 463 -2.16 65.29 REMARK 500 ASN E 616 58.50 -94.72 REMARK 500 PRO J 84 67.24 -69.87 REMARK 500 ALA J 85 14.81 -140.52 REMARK 500 LEU K 28 57.45 -94.42 REMARK 500 ASN K 51 -11.14 71.64 REMARK 500 GLN K 52 -14.55 -140.55 REMARK 500 ARG K 61 -36.40 -130.75 REMARK 500 ASN K 66C 70.24 56.26 REMARK 500 ASP K 82 31.50 -98.23 REMARK 500 THR M 71 48.54 -92.45 REMARK 500 LEU M 122 54.32 -94.75 REMARK 500 ARG M 166 49.65 -84.09 REMARK 500 ASN M 195 -67.56 -97.87 REMARK 500 CYS M 196 18.13 49.68 REMARK 500 PHE M 353 -167.78 -126.21 REMARK 500 ILE M 430 -71.74 -122.34 REMARK 500 SER M 463 -2.17 65.25 REMARK 500 ASN N 616 58.53 -94.73 REMARK 500 PRO Q 84 67.20 -69.87 REMARK 500 ALA Q 85 14.84 -140.49 REMARK 500 LEU R 28 57.43 -94.38 REMARK 500 ASN R 51 -11.10 71.65 REMARK 500 GLN R 52 -14.59 -140.57 REMARK 500 ARG R 61 -36.38 -130.72 REMARK 500 ASN R 66C 70.26 56.20 REMARK 500 REMARK 500 THIS ENTRY HAS 51 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-44482 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-44484 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-44491 RELATED DB: EMDB DBREF 9BEW G 31 513 PDB 9BEW 9BEW 31 513 DBREF 9BEW B 512 664 PDB 9BEW 9BEW 512 664 DBREF 9BEW C 1 216 PDB 9BEW 9BEW 1 216 DBREF 9BEW D 1 214 PDB 9BEW 9BEW 1 214 DBREF 9BEW H 1 216 PDB 9BEW 9BEW 1 216 DBREF 9BEW L 6 213 PDB 9BEW 9BEW 6 213 DBREF 9BEW A 31 513 PDB 9BEW 9BEW 31 513 DBREF 9BEW E 512 664 PDB 9BEW 9BEW 512 664 DBREF 9BEW F 1 216 PDB 9BEW 9BEW 1 216 DBREF 9BEW I 1 214 PDB 9BEW 9BEW 1 214 DBREF 9BEW J 1 216 PDB 9BEW 9BEW 1 216 DBREF 9BEW K 6 213 PDB 9BEW 9BEW 6 213 DBREF 9BEW M 31 513 PDB 9BEW 9BEW 31 513 DBREF 9BEW N 512 664 PDB 9BEW 9BEW 512 664 DBREF 9BEW O 1 216 PDB 9BEW 9BEW 1 216 DBREF 9BEW P 1 214 PDB 9BEW 9BEW 1 214 DBREF 9BEW Q 1 216 PDB 9BEW 9BEW 1 216 DBREF 9BEW R 6 213 PDB 9BEW 9BEW 6 213 SEQRES 1 G 483 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 G 483 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 G 483 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 G 483 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 G 483 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 G 483 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 G 483 ILE SER LEU TRP CYS GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 G 483 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 G 483 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 G 483 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 G 483 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 G 483 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 G 483 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 G 483 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 G 483 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 G 483 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 G 483 CYS PRO ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 G 483 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 G 483 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 G 483 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 G 483 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 G 483 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 G 483 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 G 483 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 G 483 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 G 483 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 G 483 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 G 483 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 G 483 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 G 483 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 G 483 ILE ILE ASN MET TRP GLN GLY CYS GLY ILE GLY GLN ALA SEQRES 32 G 483 MET TYR ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SEQRES 33 G 483 SER ASN ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SEQRES 34 G 483 SER THR ASN SER THR ASN GLU THR PHE ARG PRO GLY GLY SEQRES 35 G 483 GLY ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS SEQRES 36 G 483 TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO SEQRES 37 G 483 THR ARG ALA LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG SEQRES 38 G 483 ARG ARG SEQRES 1 B 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 B 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 B 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 B 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 B 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 B 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 B 153 ILE CYS ALA THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 B 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 B 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 B 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 B 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 C 226 GLN VAL GLN LEU LEU GLN SER GLY ALA ALA VAL THR LYS SEQRES 2 C 226 PRO GLY ALA SER VAL ARG VAL SER CYS GLU ALA SER GLY SEQRES 3 C 226 TYR ASN ILE ARG ASP TYR PHE ILE HIS TRP TRP ARG GLN SEQRES 4 C 226 ALA PRO GLY GLN GLY LEU GLN TRP VAL GLY TRP ILE ASN SEQRES 5 C 226 PRO LYS THR GLY GLN PRO ASN ASN PRO ARG GLN PHE GLN SEQRES 6 C 226 GLY ARG VAL SER LEU THR ARG HIS ALA SER TRP ASP PHE SEQRES 7 C 226 ASP THR TYR SER PHE TYR MET ASP LEU LYS ALA LEU ARG SEQRES 8 C 226 SER ASP ASP THR ALA VAL TYR PHE CYS ALA ARG GLN ARG SEQRES 9 C 226 SER ASP TYR TRP ASP PHE ASP VAL TRP GLY SER GLY THR SEQRES 10 C 226 GLN VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 C 226 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 C 226 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 C 226 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 C 226 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 C 226 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 C 226 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 C 226 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 18 C 226 GLU PRO LYS SER CYS SEQRES 1 D 206 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 D 206 SER VAL GLY ASP THR VAL THR ILE THR CYS GLN ALA ASN SEQRES 3 D 206 GLY TYR LEU ASN TRP TYR GLN GLN ARG ARG GLY LYS ALA SEQRES 4 D 206 PRO LYS LEU LEU ILE TYR ASP GLY SER LYS LEU GLU ARG SEQRES 5 D 206 GLY VAL PRO SER ARG PHE SER GLY ARG ARG TRP GLY GLN SEQRES 6 D 206 GLU TYR ASN LEU THR ILE ASN ASN LEU GLN PRO GLU ASP SEQRES 7 D 206 ILE ALA THR TYR PHE CYS GLN VAL TYR GLU PHE VAL VAL SEQRES 8 D 206 PRO GLY THR ARG LEU ASP LEU LYS ARG THR VAL ALA ALA SEQRES 9 D 206 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 10 D 206 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 11 D 206 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 12 D 206 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 13 D 206 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 14 D 206 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 15 D 206 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 16 D 206 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 H 235 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 H 235 PRO SER GLU THR LEU SER VAL THR CYS SER VAL SER GLY SEQRES 3 H 235 ASP SER MET ASN ASN TYR TYR TRP THR TRP ILE ARG GLN SEQRES 4 H 235 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR ILE SER SEQRES 5 H 235 ASP ARG GLU SER ALA THR TYR ASN PRO SER LEU ASN SER SEQRES 6 H 235 ARG VAL VAL ILE SER ARG ASP THR SER LYS ASN GLN LEU SEQRES 7 H 235 SER LEU LYS LEU ASN SER VAL THR PRO ALA ASP THR ALA SEQRES 8 H 235 VAL TYR TYR CYS ALA THR ALA ARG ARG GLY GLN ARG ILE SEQRES 9 H 235 TYR GLY VAL VAL SER PHE GLY GLU PHE PHE TYR TYR TYR SEQRES 10 H 235 SER MET ASP VAL TRP GLY LYS GLY THR THR VAL THR VAL SEQRES 11 H 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 H 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 H 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 H 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 H 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 H 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 H 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 H 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 H 235 CYS SEQRES 1 L 214 SER TYR VAL ARG PRO LEU SER VAL ALA LEU GLY GLU THR SEQRES 2 L 214 ALA ARG ILE SER CYS GLY ARG GLN ALA LEU GLY SER ARG SEQRES 3 L 214 ALA VAL GLN TRP TYR GLN HIS ARG PRO GLY GLN ALA PRO SEQRES 4 L 214 ILE LEU LEU ILE TYR ASN ASN GLN ASP ARG PRO SER GLY SEQRES 5 L 214 ILE PRO GLU ARG PHE SER GLY THR PRO ASP ILE ASN PHE SEQRES 6 L 214 GLY THR ARG ALA THR LEU THR ILE SER GLY VAL GLU ALA SEQRES 7 L 214 GLY ASP GLU ALA ASP TYR TYR CYS HIS MET TRP ASP SER SEQRES 8 L 214 ARG SER GLY PHE SER TRP SER PHE GLY GLY ALA THR ARG SEQRES 9 L 214 LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 L 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 L 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 L 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 L 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 L 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 L 214 THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER CYS SEQRES 16 L 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 L 214 ALA PRO THR GLU CYS SER SEQRES 1 A 483 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 A 483 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 A 483 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 A 483 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 A 483 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 A 483 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 A 483 ILE SER LEU TRP CYS GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 A 483 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 A 483 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 A 483 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 A 483 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 A 483 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 A 483 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 A 483 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 A 483 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 A 483 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 A 483 CYS PRO ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 A 483 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 A 483 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 A 483 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 A 483 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 A 483 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 A 483 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 A 483 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 A 483 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 A 483 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 A 483 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 A 483 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 A 483 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 A 483 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 A 483 ILE ILE ASN MET TRP GLN GLY CYS GLY ILE GLY GLN ALA SEQRES 32 A 483 MET TYR ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SEQRES 33 A 483 SER ASN ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SEQRES 34 A 483 SER THR ASN SER THR ASN GLU THR PHE ARG PRO GLY GLY SEQRES 35 A 483 GLY ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS SEQRES 36 A 483 TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO SEQRES 37 A 483 THR ARG ALA LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG SEQRES 38 A 483 ARG ARG SEQRES 1 E 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 E 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 E 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 E 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 E 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 E 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 E 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 E 153 ILE CYS ALA THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 E 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 E 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 E 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 E 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 F 226 GLN VAL GLN LEU LEU GLN SER GLY ALA ALA VAL THR LYS SEQRES 2 F 226 PRO GLY ALA SER VAL ARG VAL SER CYS GLU ALA SER GLY SEQRES 3 F 226 TYR ASN ILE ARG ASP TYR PHE ILE HIS TRP TRP ARG GLN SEQRES 4 F 226 ALA PRO GLY GLN GLY LEU GLN TRP VAL GLY TRP ILE ASN SEQRES 5 F 226 PRO LYS THR GLY GLN PRO ASN ASN PRO ARG GLN PHE GLN SEQRES 6 F 226 GLY ARG VAL SER LEU THR ARG HIS ALA SER TRP ASP PHE SEQRES 7 F 226 ASP THR TYR SER PHE TYR MET ASP LEU LYS ALA LEU ARG SEQRES 8 F 226 SER ASP ASP THR ALA VAL TYR PHE CYS ALA ARG GLN ARG SEQRES 9 F 226 SER ASP TYR TRP ASP PHE ASP VAL TRP GLY SER GLY THR SEQRES 10 F 226 GLN VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 F 226 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 F 226 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 F 226 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 F 226 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 F 226 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 F 226 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 F 226 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 18 F 226 GLU PRO LYS SER CYS SEQRES 1 I 206 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 I 206 SER VAL GLY ASP THR VAL THR ILE THR CYS GLN ALA ASN SEQRES 3 I 206 GLY TYR LEU ASN TRP TYR GLN GLN ARG ARG GLY LYS ALA SEQRES 4 I 206 PRO LYS LEU LEU ILE TYR ASP GLY SER LYS LEU GLU ARG SEQRES 5 I 206 GLY VAL PRO SER ARG PHE SER GLY ARG ARG TRP GLY GLN SEQRES 6 I 206 GLU TYR ASN LEU THR ILE ASN ASN LEU GLN PRO GLU ASP SEQRES 7 I 206 ILE ALA THR TYR PHE CYS GLN VAL TYR GLU PHE VAL VAL SEQRES 8 I 206 PRO GLY THR ARG LEU ASP LEU LYS ARG THR VAL ALA ALA SEQRES 9 I 206 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 10 I 206 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 11 I 206 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 12 I 206 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 13 I 206 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 14 I 206 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 15 I 206 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 16 I 206 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 J 235 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 J 235 PRO SER GLU THR LEU SER VAL THR CYS SER VAL SER GLY SEQRES 3 J 235 ASP SER MET ASN ASN TYR TYR TRP THR TRP ILE ARG GLN SEQRES 4 J 235 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR ILE SER SEQRES 5 J 235 ASP ARG GLU SER ALA THR TYR ASN PRO SER LEU ASN SER SEQRES 6 J 235 ARG VAL VAL ILE SER ARG ASP THR SER LYS ASN GLN LEU SEQRES 7 J 235 SER LEU LYS LEU ASN SER VAL THR PRO ALA ASP THR ALA SEQRES 8 J 235 VAL TYR TYR CYS ALA THR ALA ARG ARG GLY GLN ARG ILE SEQRES 9 J 235 TYR GLY VAL VAL SER PHE GLY GLU PHE PHE TYR TYR TYR SEQRES 10 J 235 SER MET ASP VAL TRP GLY LYS GLY THR THR VAL THR VAL SEQRES 11 J 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 J 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 J 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 J 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 J 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 J 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 J 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 J 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 J 235 CYS SEQRES 1 K 214 SER TYR VAL ARG PRO LEU SER VAL ALA LEU GLY GLU THR SEQRES 2 K 214 ALA ARG ILE SER CYS GLY ARG GLN ALA LEU GLY SER ARG SEQRES 3 K 214 ALA VAL GLN TRP TYR GLN HIS ARG PRO GLY GLN ALA PRO SEQRES 4 K 214 ILE LEU LEU ILE TYR ASN ASN GLN ASP ARG PRO SER GLY SEQRES 5 K 214 ILE PRO GLU ARG PHE SER GLY THR PRO ASP ILE ASN PHE SEQRES 6 K 214 GLY THR ARG ALA THR LEU THR ILE SER GLY VAL GLU ALA SEQRES 7 K 214 GLY ASP GLU ALA ASP TYR TYR CYS HIS MET TRP ASP SER SEQRES 8 K 214 ARG SER GLY PHE SER TRP SER PHE GLY GLY ALA THR ARG SEQRES 9 K 214 LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 K 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 K 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 K 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 K 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 K 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 K 214 THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER CYS SEQRES 16 K 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 K 214 ALA PRO THR GLU CYS SER SEQRES 1 M 483 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 M 483 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 M 483 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 M 483 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 M 483 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 M 483 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 M 483 ILE SER LEU TRP CYS GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 M 483 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 M 483 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 M 483 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 M 483 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 M 483 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 M 483 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 M 483 ALA ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 M 483 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 M 483 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 M 483 CYS PRO ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 M 483 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 M 483 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 M 483 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 M 483 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 M 483 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 M 483 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 M 483 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 M 483 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 M 483 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 M 483 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 M 483 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 M 483 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 M 483 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 M 483 ILE ILE ASN MET TRP GLN GLY CYS GLY ILE GLY GLN ALA SEQRES 32 M 483 MET TYR ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SEQRES 33 M 483 SER ASN ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SEQRES 34 M 483 SER THR ASN SER THR ASN GLU THR PHE ARG PRO GLY GLY SEQRES 35 M 483 GLY ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS SEQRES 36 M 483 TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO SEQRES 37 M 483 THR ARG ALA LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG SEQRES 38 M 483 ARG ARG SEQRES 1 N 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 N 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 N 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 N 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 N 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 N 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 N 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 N 153 ILE CYS ALA THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 N 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 N 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 N 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 N 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 O 226 GLN VAL GLN LEU LEU GLN SER GLY ALA ALA VAL THR LYS SEQRES 2 O 226 PRO GLY ALA SER VAL ARG VAL SER CYS GLU ALA SER GLY SEQRES 3 O 226 TYR ASN ILE ARG ASP TYR PHE ILE HIS TRP TRP ARG GLN SEQRES 4 O 226 ALA PRO GLY GLN GLY LEU GLN TRP VAL GLY TRP ILE ASN SEQRES 5 O 226 PRO LYS THR GLY GLN PRO ASN ASN PRO ARG GLN PHE GLN SEQRES 6 O 226 GLY ARG VAL SER LEU THR ARG HIS ALA SER TRP ASP PHE SEQRES 7 O 226 ASP THR TYR SER PHE TYR MET ASP LEU LYS ALA LEU ARG SEQRES 8 O 226 SER ASP ASP THR ALA VAL TYR PHE CYS ALA ARG GLN ARG SEQRES 9 O 226 SER ASP TYR TRP ASP PHE ASP VAL TRP GLY SER GLY THR SEQRES 10 O 226 GLN VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 O 226 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 O 226 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 O 226 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 O 226 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 O 226 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 O 226 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 O 226 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 18 O 226 GLU PRO LYS SER CYS SEQRES 1 P 206 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 P 206 SER VAL GLY ASP THR VAL THR ILE THR CYS GLN ALA ASN SEQRES 3 P 206 GLY TYR LEU ASN TRP TYR GLN GLN ARG ARG GLY LYS ALA SEQRES 4 P 206 PRO LYS LEU LEU ILE TYR ASP GLY SER LYS LEU GLU ARG SEQRES 5 P 206 GLY VAL PRO SER ARG PHE SER GLY ARG ARG TRP GLY GLN SEQRES 6 P 206 GLU TYR ASN LEU THR ILE ASN ASN LEU GLN PRO GLU ASP SEQRES 7 P 206 ILE ALA THR TYR PHE CYS GLN VAL TYR GLU PHE VAL VAL SEQRES 8 P 206 PRO GLY THR ARG LEU ASP LEU LYS ARG THR VAL ALA ALA SEQRES 9 P 206 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 10 P 206 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 11 P 206 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 12 P 206 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 13 P 206 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 14 P 206 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 15 P 206 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 16 P 206 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 Q 235 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 Q 235 PRO SER GLU THR LEU SER VAL THR CYS SER VAL SER GLY SEQRES 3 Q 235 ASP SER MET ASN ASN TYR TYR TRP THR TRP ILE ARG GLN SEQRES 4 Q 235 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR ILE SER SEQRES 5 Q 235 ASP ARG GLU SER ALA THR TYR ASN PRO SER LEU ASN SER SEQRES 6 Q 235 ARG VAL VAL ILE SER ARG ASP THR SER LYS ASN GLN LEU SEQRES 7 Q 235 SER LEU LYS LEU ASN SER VAL THR PRO ALA ASP THR ALA SEQRES 8 Q 235 VAL TYR TYR CYS ALA THR ALA ARG ARG GLY GLN ARG ILE SEQRES 9 Q 235 TYR GLY VAL VAL SER PHE GLY GLU PHE PHE TYR TYR TYR SEQRES 10 Q 235 SER MET ASP VAL TRP GLY LYS GLY THR THR VAL THR VAL SEQRES 11 Q 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 Q 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 Q 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 Q 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 Q 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 Q 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 Q 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 Q 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 Q 235 CYS SEQRES 1 R 214 SER TYR VAL ARG PRO LEU SER VAL ALA LEU GLY GLU THR SEQRES 2 R 214 ALA ARG ILE SER CYS GLY ARG GLN ALA LEU GLY SER ARG SEQRES 3 R 214 ALA VAL GLN TRP TYR GLN HIS ARG PRO GLY GLN ALA PRO SEQRES 4 R 214 ILE LEU LEU ILE TYR ASN ASN GLN ASP ARG PRO SER GLY SEQRES 5 R 214 ILE PRO GLU ARG PHE SER GLY THR PRO ASP ILE ASN PHE SEQRES 6 R 214 GLY THR ARG ALA THR LEU THR ILE SER GLY VAL GLU ALA SEQRES 7 R 214 GLY ASP GLU ALA ASP TYR TYR CYS HIS MET TRP ASP SER SEQRES 8 R 214 ARG SER GLY PHE SER TRP SER PHE GLY GLY ALA THR ARG SEQRES 9 R 214 LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 R 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 R 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 R 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 R 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 R 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 R 214 THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER CYS SEQRES 16 R 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 R 214 ALA PRO THR GLU CYS SER HET NAG G 601 14 HET NAG G 602 14 HET NAG G 603 14 HET NAG G 604 14 HET NAG G 605 14 HET NAG G 606 14 HET NAG G 607 14 HET NAG G 608 14 HET NAG G 609 14 HET NAG G 610 14 HET NAG B 701 14 HET NAG B 702 14 HET NAG D 301 14 HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG A 604 14 HET NAG A 605 14 HET NAG A 606 14 HET NAG A 607 14 HET NAG A 608 14 HET NAG A 609 14 HET NAG A 610 14 HET NAG E 701 14 HET NAG E 702 14 HET NAG I 301 14 HET NAG M 601 14 HET NAG M 602 14 HET NAG M 603 14 HET NAG M 604 14 HET NAG M 605 14 HET NAG M 606 14 HET NAG M 607 14 HET NAG M 608 14 HET NAG M 609 14 HET NAG M 610 14 HET NAG N 701 14 HET NAG N 702 14 HET NAG P 301 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET BMA V 3 11 HET MAN V 4 11 HET MAN V 5 11 HET MAN V 6 11 HET NAG W 1 14 HET NAG W 2 14 HET BMA W 3 11 HET MAN W 4 11 HET MAN W 5 11 HET NAG X 1 14 HET NAG X 2 14 HET BMA X 3 11 HET MAN X 4 11 HET NAG Y 1 14 HET NAG Y 2 14 HET NAG Z 1 14 HET NAG Z 2 14 HET BMA Z 3 11 HET MAN Z 4 11 HET MAN Z 5 11 HET MAN Z 6 11 HET MAN Z 7 11 HET MAN Z 8 11 HET MAN Z 9 11 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET NAG c 1 14 HET NAG c 2 14 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET MAN d 4 11 HET MAN d 5 11 HET MAN d 6 11 HET NAG e 1 14 HET NAG e 2 14 HET BMA e 3 11 HET MAN e 4 11 HET MAN e 5 11 HET NAG f 1 14 HET NAG f 2 14 HET BMA f 3 11 HET MAN f 4 11 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET BMA h 3 11 HET MAN h 4 11 HET MAN h 5 11 HET MAN h 6 11 HET MAN h 7 11 HET MAN h 8 11 HET MAN h 9 11 HET NAG i 1 14 HET NAG i 2 14 HET NAG j 1 14 HET NAG j 2 14 HET NAG k 1 14 HET NAG k 2 14 HET NAG l 1 14 HET NAG l 2 14 HET BMA l 3 11 HET MAN l 4 11 HET MAN l 5 11 HET MAN l 6 11 HET NAG m 1 14 HET NAG m 2 14 HET BMA m 3 11 HET MAN m 4 11 HET MAN m 5 11 HET NAG n 1 14 HET NAG n 2 14 HET BMA n 3 11 HET MAN n 4 11 HET NAG o 1 14 HET NAG o 2 14 HET NAG p 1 14 HET NAG p 2 14 HET BMA p 3 11 HET MAN p 4 11 HET MAN p 5 11 HET MAN p 6 11 HET MAN p 7 11 HET MAN p 8 11 HET MAN p 9 11 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 19 NAG 87(C8 H15 N O6) FORMUL 61 BMA 12(C6 H12 O6) FORMUL 61 MAN 36(C6 H12 O6) HELIX 1 AA1 ASN G 98 CYS G 113 1 16 HELIX 2 AA2 LEU G 122 CYS G 126 5 5 HELIX 3 AA3 LYS G 335 ARG G 350 1 16 HELIX 4 AA4 ASP G 368 THR G 373 1 6 HELIX 5 AA5 ASN G 377 GLU G 381 5 5 HELIX 6 AA6 MET G 426 GLY G 429B 1 6 HELIX 7 AA7 ARG G 476 SER G 481 1 6 HELIX 8 AA8 THR B 529 SER B 534 1 6 HELIX 9 AA9 LEU B 537 ARG B 542 1 6 HELIX 10 AB1 ASN B 543 LEU B 545 5 3 HELIX 11 AB2 LEU B 566 VAL B 570 5 5 HELIX 12 AB3 ILE B 573 GLY B 597 1 25 HELIX 13 AB4 THR B 627 SER B 636 1 10 HELIX 14 AB5 TYR B 638 GLN B 658 1 21 HELIX 15 AB6 ASN C 28 TYR C 32 5 5 HELIX 16 AB7 PRO C 60 GLN C 64 5 5 HELIX 17 AB8 ARG C 83 THR C 87 5 5 HELIX 18 AB9 PRO H 61 ASN H 64 5 4 HELIX 19 AC1 ASN A 98 CYS A 113 1 16 HELIX 20 AC2 LEU A 122 CYS A 126 5 5 HELIX 21 AC3 LYS A 335 ARG A 350 1 16 HELIX 22 AC4 ASP A 368 THR A 373 1 6 HELIX 23 AC5 ASN A 377 GLU A 381 5 5 HELIX 24 AC6 MET A 426 GLY A 429B 1 6 HELIX 25 AC7 ARG A 476 SER A 481 1 6 HELIX 26 AC8 THR E 529 SER E 534 1 6 HELIX 27 AC9 LEU E 537 ARG E 542 1 6 HELIX 28 AD1 ASN E 543 LEU E 545 5 3 HELIX 29 AD2 LEU E 566 VAL E 570 5 5 HELIX 30 AD3 ILE E 573 GLY E 597 1 25 HELIX 31 AD4 THR E 627 SER E 636 1 10 HELIX 32 AD5 TYR E 638 GLN E 658 1 21 HELIX 33 AD6 ASN F 28 TYR F 32 5 5 HELIX 34 AD7 PRO F 60 GLN F 64 5 5 HELIX 35 AD8 ARG F 83 THR F 87 5 5 HELIX 36 AD9 PRO J 61 ASN J 64 5 4 HELIX 37 AE1 ASN M 98 CYS M 113 1 16 HELIX 38 AE2 LEU M 122 CYS M 126 5 5 HELIX 39 AE3 LYS M 335 ARG M 350 1 16 HELIX 40 AE4 ASP M 368 THR M 373 1 6 HELIX 41 AE5 ASN M 377 GLU M 381 5 5 HELIX 42 AE6 MET M 426 GLY M 429B 1 6 HELIX 43 AE7 ARG M 476 SER M 481 1 6 HELIX 44 AE8 THR N 529 SER N 534 1 6 HELIX 45 AE9 LEU N 537 ARG N 542 1 6 HELIX 46 AF1 ASN N 543 LEU N 545 5 3 HELIX 47 AF2 LEU N 566 VAL N 570 5 5 HELIX 48 AF3 ILE N 573 GLY N 597 1 25 HELIX 49 AF4 THR N 627 SER N 636 1 10 HELIX 50 AF5 TYR N 638 GLN N 658 1 21 HELIX 51 AF6 ASN O 28 TYR O 32 5 5 HELIX 52 AF7 PRO O 60 GLN O 64 5 5 HELIX 53 AF8 ARG O 83 THR O 87 5 5 HELIX 54 AF9 PRO Q 61 ASN Q 64 5 4 SHEET 1 AA1 3 LEU G 494 THR G 499 0 SHEET 2 AA1 3 TRP G 35 TYR G 40 -1 N TRP G 35 O THR G 499 SHEET 3 AA1 3 ILE B 603 PRO B 609 -1 O CYS B 604 N VAL G 38 SHEET 1 AA2 5 TRP G 45 ASP G 47 0 SHEET 2 AA2 5 TYR G 486 ILE G 491 -1 O LYS G 490 N LYS G 46 SHEET 3 AA2 5 PHE G 223 CYS G 228 -1 N ALA G 224 O VAL G 489 SHEET 4 AA2 5 VAL G 242 VAL G 245 -1 O SER G 243 N LYS G 227 SHEET 5 AA2 5 GLU G 83 LEU G 86 -1 N ILE G 84 O THR G 244 SHEET 1 AA3 3 VAL G 75 PRO G 76 0 SHEET 2 AA3 3 PHE G 53 SER G 56 1 N CYS G 54 O VAL G 75 SHEET 3 AA3 3 HIS G 216 CYS G 218 -1 O CYS G 218 N PHE G 53 SHEET 1 AA4 2 GLU G 91 ASN G 94 0 SHEET 2 AA4 2 THR G 236 CYS G 239 -1 O CYS G 239 N GLU G 91 SHEET 1 AA5 3 GLN G 130 ASN G 133 0 SHEET 2 AA5 3 LEU G 154 THR G 162 -1 O ASN G 156 N THR G 132 SHEET 3 AA5 3 LYS G 169 TYR G 177 -1 O PHE G 176 N LYS G 155 SHEET 1 AA6 2 VAL G 181 GLN G 183 0 SHEET 2 AA6 2 TYR G 191 LEU G 193 -1 O ARG G 192 N VAL G 182 SHEET 1 AA7 3 ILE G 201 GLN G 203 0 SHEET 2 AA7 3 ALA G 433 TYR G 435 1 O TYR G 435 N THR G 202 SHEET 3 AA7 3 ILE G 423 ILE G 424 -1 N ILE G 424 O MET G 434 SHEET 1 AA813 LEU G 259 LEU G 261 0 SHEET 2 AA813 MET G 271 ARG G 273 0 SHEET 3 AA813 ILE G 284 GLN G 287 -1 O LEU G 285 N ARG G 273 SHEET 4 AA813 VAL G 292 GLY G 312 0 SHEET 5 AA813 GLN G 315 ILE G 322 -1 O PHE G 317 N ILE G 307 SHEET 6 AA813 HIS G 330 SER G 334 -1 O ASN G 332 N ASN G 295 SHEET 7 AA813 ILE G 358 PHE G 361 0 SHEET 8 AA813 HIS G 374 PHE G 376 0 SHEET 9 AA813 PHE G 382 CYS G 385 -1 O CYS G 385 N HIS G 374 SHEET 10 AA813 SER G 393 TRP G 395 -1 O TRP G 395 N ILE G 359 SHEET 11 AA813 SER G 413 LYS G 421 -1 O LYS G 421 N PHE G 382 SHEET 12 AA813 GLY G 441 ARG G 456 -1 O CYS G 445 N CYS G 296 SHEET 13 AA813 ASN G 465 PRO G 470 -1 O ARG G 469 N THR G 455 SHEET 1 AA9 2 LEU C 4 GLN C 6 0 SHEET 2 AA9 2 CYS C 22 ALA C 24 -1 O GLU C 23 N LEU C 5 SHEET 1 AB1 5 ALA C 10 VAL C 11 0 SHEET 2 AB1 5 THR C 107 THR C 110 1 O THR C 110 N ALA C 10 SHEET 3 AB1 5 ALA C 88 CYS C 92 -1 N ALA C 88 O VAL C 109 SHEET 4 AB1 5 ILE C 34 GLN C 39 -1 N TRP C 37 O PHE C 91 SHEET 5 AB1 5 LEU C 45 ILE C 51 -1 O VAL C 48 N TRP C 36 SHEET 1 AB2 3 VAL C 18 ARG C 19 0 SHEET 2 AB2 3 TYR C 76 LEU C 82 -1 O LEU C 82 N VAL C 18 SHEET 3 AB2 3 VAL C 67 ALA C 71B-1 N THR C 70 O TYR C 79 SHEET 1 AB3 3 THR D 18 CYS D 23 0 SHEET 2 AB3 3 TYR D 71 ASN D 76 -1 O ILE D 75 N VAL D 19 SHEET 3 AB3 3 PHE D 62 ARG D 66 -1 N SER D 63 O THR D 74 SHEET 1 AB4 5 LYS D 53 LEU D 54 0 SHEET 2 AB4 5 LYS D 45 TYR D 49 -1 N TYR D 49 O LYS D 53 SHEET 3 AB4 5 ASN D 34 GLN D 38 -1 N GLN D 37 O LYS D 45 SHEET 4 AB4 5 THR D 85 GLN D 89 -1 O THR D 85 N GLN D 38 SHEET 5 AB4 5 THR D 102 ARG D 103 -1 O THR D 102 N TYR D 86 SHEET 1 AB5 4 GLN H 3 SER H 7 0 SHEET 2 AB5 4 THR H 21 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AB5 4 GLN H 77 LEU H 82 -1 O LEU H 78 N CYS H 22 SHEET 4 AB5 4 VAL H 67 ASP H 72 -1 N VAL H 68 O LYS H 81 SHEET 1 AB6 7 LEU H 11 VAL H 12 0 SHEET 2 AB6 7 TYR H 33 GLN H 39 0 SHEET 3 AB6 7 LEU H 45 ILE H 51 -1 O GLU H 46 N ARG H 38 SHEET 4 AB6 7 ALA H 57 TYR H 59 -1 O THR H 58 N TYR H 50 SHEET 5 AB6 7 ALA H 88 ILE H 100A-1 O VAL H 89 N GLN H 39 SHEET 6 AB6 7 PHE H 100J SER H 100O-1 O TYR H 100M N GLY H 98 SHEET 7 AB6 7 THR H 108 VAL H 111 -1 O VAL H 109 N ALA H 88 SHEET 1 AB7 3 VAL L 8 VAL L 13 0 SHEET 2 AB7 3 ALA L 101 VAL L 106 1 O THR L 105 N LEU L 11 SHEET 3 AB7 3 ASP L 85 TYR L 86 -1 N TYR L 86 O THR L 102 SHEET 1 AB8 3 ALA L 19 ILE L 21 0 SHEET 2 AB8 3 LEU L 73 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 3 AB8 3 PHE L 62 GLY L 64 -1 N SER L 63 O THR L 74 SHEET 1 AB9 3 ILE L 45 ILE L 48 0 SHEET 2 AB9 3 GLN L 34 GLN L 37 -1 N GLN L 37 O ILE L 45 SHEET 3 AB9 3 CYS L 88 HIS L 89 -1 O HIS L 89 N GLN L 34 SHEET 1 AC1 3 LEU A 494 THR A 499 0 SHEET 2 AC1 3 TRP A 35 TYR A 40 -1 N TRP A 35 O THR A 499 SHEET 3 AC1 3 ILE E 603 PRO E 609 -1 O CYS E 604 N VAL A 38 SHEET 1 AC2 5 TRP A 45 ASP A 47 0 SHEET 2 AC2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AC2 5 PHE A 223 CYS A 228 -1 N ALA A 224 O VAL A 489 SHEET 4 AC2 5 VAL A 242 VAL A 245 -1 O SER A 243 N LYS A 227 SHEET 5 AC2 5 GLU A 83 LEU A 86 -1 N ILE A 84 O THR A 244 SHEET 1 AC3 3 VAL A 75 PRO A 76 0 SHEET 2 AC3 3 PHE A 53 SER A 56 1 N CYS A 54 O VAL A 75 SHEET 3 AC3 3 HIS A 216 CYS A 218 -1 O CYS A 218 N PHE A 53 SHEET 1 AC4 2 GLU A 91 ASN A 94 0 SHEET 2 AC4 2 THR A 236 CYS A 239 -1 O CYS A 239 N GLU A 91 SHEET 1 AC5 3 GLN A 130 ASN A 133 0 SHEET 2 AC5 3 LEU A 154 THR A 162 -1 O ASN A 156 N THR A 132 SHEET 3 AC5 3 LYS A 169 TYR A 177 -1 O PHE A 176 N LYS A 155 SHEET 1 AC6 2 VAL A 181 GLN A 183 0 SHEET 2 AC6 2 TYR A 191 LEU A 193 -1 O ARG A 192 N VAL A 182 SHEET 1 AC7 3 ILE A 201 GLN A 203 0 SHEET 2 AC7 3 ALA A 433 TYR A 435 1 O TYR A 435 N THR A 202 SHEET 3 AC7 3 ILE A 423 ILE A 424 -1 N ILE A 424 O MET A 434 SHEET 1 AC813 LEU A 259 LEU A 261 0 SHEET 2 AC813 MET A 271 ARG A 273 0 SHEET 3 AC813 ILE A 284 GLN A 287 -1 O LEU A 285 N ARG A 273 SHEET 4 AC813 VAL A 292 GLY A 312 0 SHEET 5 AC813 GLN A 315 ILE A 322 -1 O PHE A 317 N ILE A 307 SHEET 6 AC813 HIS A 330 SER A 334 -1 O ASN A 332 N ASN A 295 SHEET 7 AC813 ILE A 358 PHE A 361 0 SHEET 8 AC813 HIS A 374 PHE A 376 0 SHEET 9 AC813 PHE A 382 CYS A 385 -1 O CYS A 385 N HIS A 374 SHEET 10 AC813 SER A 393 TRP A 395 -1 O TRP A 395 N ILE A 359 SHEET 11 AC813 SER A 413 LYS A 421 -1 O LYS A 421 N PHE A 382 SHEET 12 AC813 GLY A 441 ARG A 456 -1 O CYS A 445 N CYS A 296 SHEET 13 AC813 ASN A 465 PRO A 470 -1 O ARG A 469 N THR A 455 SHEET 1 AC9 2 LEU F 4 GLN F 6 0 SHEET 2 AC9 2 CYS F 22 ALA F 24 -1 O GLU F 23 N LEU F 5 SHEET 1 AD1 5 ALA F 10 VAL F 11 0 SHEET 2 AD1 5 THR F 107 THR F 110 1 O THR F 110 N ALA F 10 SHEET 3 AD1 5 ALA F 88 CYS F 92 -1 N ALA F 88 O VAL F 109 SHEET 4 AD1 5 ILE F 34 GLN F 39 -1 N TRP F 37 O PHE F 91 SHEET 5 AD1 5 LEU F 45 ILE F 51 -1 O VAL F 48 N TRP F 36 SHEET 1 AD2 3 VAL F 18 ARG F 19 0 SHEET 2 AD2 3 TYR F 76 LEU F 82 -1 O LEU F 82 N VAL F 18 SHEET 3 AD2 3 VAL F 67 ALA F 71B-1 N THR F 70 O TYR F 79 SHEET 1 AD3 3 THR I 18 CYS I 23 0 SHEET 2 AD3 3 TYR I 71 ASN I 76 -1 O ILE I 75 N VAL I 19 SHEET 3 AD3 3 PHE I 62 ARG I 66 -1 N SER I 63 O THR I 74 SHEET 1 AD4 5 LYS I 53 LEU I 54 0 SHEET 2 AD4 5 LYS I 45 TYR I 49 -1 N TYR I 49 O LYS I 53 SHEET 3 AD4 5 ASN I 34 GLN I 38 -1 N GLN I 37 O LYS I 45 SHEET 4 AD4 5 THR I 85 GLN I 89 -1 O THR I 85 N GLN I 38 SHEET 5 AD4 5 THR I 102 ARG I 103 -1 O THR I 102 N TYR I 86 SHEET 1 AD5 4 GLN J 3 SER J 7 0 SHEET 2 AD5 4 THR J 21 SER J 25 -1 O SER J 25 N GLN J 3 SHEET 3 AD5 4 GLN J 77 LEU J 82 -1 O LEU J 78 N CYS J 22 SHEET 4 AD5 4 VAL J 67 ASP J 72 -1 N VAL J 68 O LYS J 81 SHEET 1 AD6 7 LEU J 11 VAL J 12 0 SHEET 2 AD6 7 TYR J 33 GLN J 39 0 SHEET 3 AD6 7 LEU J 45 ILE J 51 -1 O GLU J 46 N ARG J 38 SHEET 4 AD6 7 ALA J 57 TYR J 59 -1 O THR J 58 N TYR J 50 SHEET 5 AD6 7 ALA J 88 ILE J 100A-1 O VAL J 89 N GLN J 39 SHEET 6 AD6 7 PHE J 100J SER J 100O-1 O TYR J 100M N GLY J 98 SHEET 7 AD6 7 THR J 108 VAL J 111 -1 O VAL J 109 N ALA J 88 SHEET 1 AD7 3 VAL K 8 VAL K 13 0 SHEET 2 AD7 3 ALA K 101 VAL K 106 1 O THR K 105 N LEU K 11 SHEET 3 AD7 3 ASP K 85 TYR K 86 -1 N TYR K 86 O THR K 102 SHEET 1 AD8 3 ALA K 19 ILE K 21 0 SHEET 2 AD8 3 LEU K 73 ILE K 75 -1 O LEU K 73 N ILE K 21 SHEET 3 AD8 3 PHE K 62 GLY K 64 -1 N SER K 63 O THR K 74 SHEET 1 AD9 3 ILE K 45 ILE K 48 0 SHEET 2 AD9 3 GLN K 34 GLN K 37 -1 N GLN K 37 O ILE K 45 SHEET 3 AD9 3 CYS K 88 HIS K 89 -1 O HIS K 89 N GLN K 34 SHEET 1 AE1 3 LEU M 494 THR M 499 0 SHEET 2 AE1 3 TRP M 35 TYR M 40 -1 N TRP M 35 O THR M 499 SHEET 3 AE1 3 ILE N 603 PRO N 609 -1 O CYS N 604 N VAL M 38 SHEET 1 AE2 5 TRP M 45 ASP M 47 0 SHEET 2 AE2 5 TYR M 486 ILE M 491 -1 O LYS M 490 N LYS M 46 SHEET 3 AE2 5 PHE M 223 CYS M 228 -1 N ALA M 224 O VAL M 489 SHEET 4 AE2 5 VAL M 242 VAL M 245 -1 O SER M 243 N LYS M 227 SHEET 5 AE2 5 GLU M 83 LEU M 86 -1 N ILE M 84 O THR M 244 SHEET 1 AE3 3 VAL M 75 PRO M 76 0 SHEET 2 AE3 3 PHE M 53 SER M 56 1 N CYS M 54 O VAL M 75 SHEET 3 AE3 3 HIS M 216 CYS M 218 -1 O CYS M 218 N PHE M 53 SHEET 1 AE4 2 GLU M 91 ASN M 94 0 SHEET 2 AE4 2 THR M 236 CYS M 239 -1 O CYS M 239 N GLU M 91 SHEET 1 AE5 3 GLN M 130 ASN M 133 0 SHEET 2 AE5 3 LEU M 154 THR M 162 -1 O ASN M 156 N THR M 132 SHEET 3 AE5 3 LYS M 169 TYR M 177 -1 O PHE M 176 N LYS M 155 SHEET 1 AE6 2 VAL M 181 GLN M 183 0 SHEET 2 AE6 2 TYR M 191 LEU M 193 -1 O ARG M 192 N VAL M 182 SHEET 1 AE7 3 ILE M 201 GLN M 203 0 SHEET 2 AE7 3 ALA M 433 TYR M 435 1 O TYR M 435 N THR M 202 SHEET 3 AE7 3 ILE M 423 ILE M 424 -1 N ILE M 424 O MET M 434 SHEET 1 AE813 LEU M 259 LEU M 261 0 SHEET 2 AE813 MET M 271 ARG M 273 0 SHEET 3 AE813 ILE M 284 GLN M 287 -1 O LEU M 285 N ARG M 273 SHEET 4 AE813 VAL M 292 GLY M 312 0 SHEET 5 AE813 GLN M 315 ILE M 322 -1 O PHE M 317 N ILE M 307 SHEET 6 AE813 HIS M 330 SER M 334 -1 O ASN M 332 N ASN M 295 SHEET 7 AE813 ILE M 358 PHE M 361 0 SHEET 8 AE813 HIS M 374 PHE M 376 0 SHEET 9 AE813 PHE M 382 CYS M 385 -1 O CYS M 385 N HIS M 374 SHEET 10 AE813 SER M 393 TRP M 395 -1 O TRP M 395 N ILE M 359 SHEET 11 AE813 SER M 413 LYS M 421 -1 O LYS M 421 N PHE M 382 SHEET 12 AE813 GLY M 441 ARG M 456 -1 O CYS M 445 N CYS M 296 SHEET 13 AE813 ASN M 465 PRO M 470 -1 O ARG M 469 N THR M 455 SHEET 1 AE9 2 LEU O 4 GLN O 6 0 SHEET 2 AE9 2 CYS O 22 ALA O 24 -1 O GLU O 23 N LEU O 5 SHEET 1 AF1 5 ALA O 10 VAL O 11 0 SHEET 2 AF1 5 THR O 107 THR O 110 1 O THR O 110 N ALA O 10 SHEET 3 AF1 5 ALA O 88 CYS O 92 -1 N ALA O 88 O VAL O 109 SHEET 4 AF1 5 ILE O 34 GLN O 39 -1 N TRP O 37 O PHE O 91 SHEET 5 AF1 5 LEU O 45 ILE O 51 -1 O VAL O 48 N TRP O 36 SHEET 1 AF2 3 VAL O 18 ARG O 19 0 SHEET 2 AF2 3 TYR O 76 LEU O 82 -1 O LEU O 82 N VAL O 18 SHEET 3 AF2 3 VAL O 67 ALA O 71B-1 N THR O 70 O TYR O 79 SHEET 1 AF3 3 THR P 18 CYS P 23 0 SHEET 2 AF3 3 TYR P 71 ASN P 76 -1 O ILE P 75 N VAL P 19 SHEET 3 AF3 3 PHE P 62 ARG P 66 -1 N SER P 63 O THR P 74 SHEET 1 AF4 5 LYS P 53 LEU P 54 0 SHEET 2 AF4 5 LYS P 45 TYR P 49 -1 N TYR P 49 O LYS P 53 SHEET 3 AF4 5 ASN P 34 GLN P 38 -1 N GLN P 37 O LYS P 45 SHEET 4 AF4 5 THR P 85 GLN P 89 -1 O THR P 85 N GLN P 38 SHEET 5 AF4 5 THR P 102 ARG P 103 -1 O THR P 102 N TYR P 86 SHEET 1 AF5 4 GLN Q 3 SER Q 7 0 SHEET 2 AF5 4 THR Q 21 SER Q 25 -1 O SER Q 25 N GLN Q 3 SHEET 3 AF5 4 GLN Q 77 LEU Q 82 -1 O LEU Q 78 N CYS Q 22 SHEET 4 AF5 4 VAL Q 67 ASP Q 72 -1 N VAL Q 68 O LYS Q 81 SHEET 1 AF6 7 LEU Q 11 VAL Q 12 0 SHEET 2 AF6 7 TYR Q 33 GLN Q 39 0 SHEET 3 AF6 7 LEU Q 45 ILE Q 51 -1 O GLU Q 46 N ARG Q 38 SHEET 4 AF6 7 ALA Q 57 TYR Q 59 -1 O THR Q 58 N TYR Q 50 SHEET 5 AF6 7 ALA Q 88 ILE Q 100A-1 O VAL Q 89 N GLN Q 39 SHEET 6 AF6 7 PHE Q 100J SER Q 100O-1 O TYR Q 100M N GLY Q 98 SHEET 7 AF6 7 THR Q 108 VAL Q 111 -1 O VAL Q 109 N ALA Q 88 SHEET 1 AF7 3 VAL R 8 VAL R 13 0 SHEET 2 AF7 3 ALA R 101 VAL R 106 1 O THR R 105 N LEU R 11 SHEET 3 AF7 3 ASP R 85 TYR R 86 -1 N TYR R 86 O THR R 102 SHEET 1 AF8 3 ALA R 19 ILE R 21 0 SHEET 2 AF8 3 LEU R 73 ILE R 75 -1 O LEU R 73 N ILE R 21 SHEET 3 AF8 3 PHE R 62 GLY R 64 -1 N SER R 63 O THR R 74 SHEET 1 AF9 3 ILE R 45 ILE R 48 0 SHEET 2 AF9 3 GLN R 34 GLN R 37 -1 N GLN R 37 O ILE R 45 SHEET 3 AF9 3 CYS R 88 HIS R 89 -1 O HIS R 89 N GLN R 34 SSBOND 1 CYS G 54 CYS G 74 1555 1555 2.03 SSBOND 2 CYS G 113 CYS G 429A 1555 1555 2.03 SSBOND 3 CYS G 119 CYS G 205 1555 1555 2.04 SSBOND 4 CYS G 126 CYS G 196 1555 1555 2.03 SSBOND 5 CYS G 131 CYS G 157 1555 1555 2.03 SSBOND 6 CYS G 218 CYS G 247 1555 1555 2.04 SSBOND 7 CYS G 228 CYS G 239 1555 1555 2.03 SSBOND 8 CYS G 296 CYS G 331 1555 1555 2.03 SSBOND 9 CYS G 378 CYS G 445 1555 1555 2.03 SSBOND 10 CYS G 385 CYS G 418 1555 1555 2.03 SSBOND 11 CYS B 598 CYS B 604 1555 1555 2.03 SSBOND 12 CYS C 22 CYS C 92 1555 1555 2.03 SSBOND 13 CYS D 23 CYS D 88 1555 1555 2.03 SSBOND 14 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 15 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 16 CYS A 54 CYS A 74 1555 1555 2.03 SSBOND 17 CYS A 113 CYS A 429A 1555 1555 2.03 SSBOND 18 CYS A 119 CYS A 205 1555 1555 2.04 SSBOND 19 CYS A 126 CYS A 196 1555 1555 2.03 SSBOND 20 CYS A 131 CYS A 157 1555 1555 2.03 SSBOND 21 CYS A 218 CYS A 247 1555 1555 2.05 SSBOND 22 CYS A 228 CYS A 239 1555 1555 2.03 SSBOND 23 CYS A 296 CYS A 331 1555 1555 2.03 SSBOND 24 CYS A 378 CYS A 445 1555 1555 2.03 SSBOND 25 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 26 CYS E 598 CYS E 604 1555 1555 2.03 SSBOND 27 CYS F 22 CYS F 92 1555 1555 2.03 SSBOND 28 CYS I 23 CYS I 88 1555 1555 2.03 SSBOND 29 CYS J 22 CYS J 92 1555 1555 2.03 SSBOND 30 CYS K 23 CYS K 88 1555 1555 2.03 SSBOND 31 CYS M 54 CYS M 74 1555 1555 2.03 SSBOND 32 CYS M 113 CYS M 429A 1555 1555 2.03 SSBOND 33 CYS M 119 CYS M 205 1555 1555 2.04 SSBOND 34 CYS M 126 CYS M 196 1555 1555 2.03 SSBOND 35 CYS M 131 CYS M 157 1555 1555 2.03 SSBOND 36 CYS M 218 CYS M 247 1555 1555 2.04 SSBOND 37 CYS M 228 CYS M 239 1555 1555 2.03 SSBOND 38 CYS M 296 CYS M 331 1555 1555 2.03 SSBOND 39 CYS M 378 CYS M 445 1555 1555 2.03 SSBOND 40 CYS M 385 CYS M 418 1555 1555 2.03 SSBOND 41 CYS N 598 CYS N 604 1555 1555 2.03 SSBOND 42 CYS O 22 CYS O 92 1555 1555 2.03 SSBOND 43 CYS P 23 CYS P 88 1555 1555 2.03 SSBOND 44 CYS Q 22 CYS Q 92 1555 1555 2.03 SSBOND 45 CYS R 23 CYS R 88 1555 1555 2.03 LINK ND2 ASN G 88 C1 NAG G 601 1555 1555 1.44 LINK ND2 ASN G 133 C1 NAG G 602 1555 1555 1.44 LINK ND2 ASN G 156 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN G 160 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN G 197 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN G 234 C1 NAG G 603 1555 1555 1.45 LINK ND2 ASN G 241 C1 NAG G 610 1555 1555 1.44 LINK ND2 ASN G 262 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN G 276 C1 NAG G 604 1555 1555 1.44 LINK ND2 ASN G 295 C1 NAG G 605 1555 1555 1.44 LINK ND2 ASN G 301 C1 NAG G 606 1555 1555 1.44 LINK ND2 ASN G 332 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN G 339 C1 NAG G 607 1555 1555 1.45 LINK ND2 ASN G 355 C1 NAG G 608 1555 1555 1.44 LINK ND2 ASN G 363 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN G 386 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN G 392 C1 NAG G 609 1555 1555 1.44 LINK ND2 ASN G 448 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN B 611 C1 NAG B 701 1555 1555 1.44 LINK ND2 ASN B 637 C1 NAG B 702 1555 1555 1.44 LINK ND2 ASN D 72 C1 NAG D 301 1555 1555 1.44 LINK ND2 ASN A 88 C1 NAG A 601 1555 1555 1.44 LINK ND2 ASN A 133 C1 NAG A 602 1555 1555 1.44 LINK ND2 ASN A 156 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN A 160 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN A 197 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A 603 1555 1555 1.45 LINK ND2 ASN A 241 C1 NAG A 610 1555 1555 1.44 LINK ND2 ASN A 262 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN A 276 C1 NAG A 604 1555 1555 1.44 LINK ND2 ASN A 295 C1 NAG A 605 1555 1555 1.44 LINK ND2 ASN A 301 C1 NAG A 606 1555 1555 1.44 LINK ND2 ASN A 332 C1 NAG h 1 1555 1555 1.44 LINK ND2 ASN A 339 C1 NAG A 607 1555 1555 1.45 LINK ND2 ASN A 355 C1 NAG A 608 1555 1555 1.44 LINK ND2 ASN A 363 C1 NAG e 1 1555 1555 1.44 LINK ND2 ASN A 386 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN A 392 C1 NAG A 609 1555 1555 1.44 LINK ND2 ASN A 448 C1 NAG g 1 1555 1555 1.44 LINK ND2 ASN E 611 C1 NAG E 701 1555 1555 1.44 LINK ND2 ASN E 637 C1 NAG E 702 1555 1555 1.44 LINK ND2 ASN I 72 C1 NAG I 301 1555 1555 1.44 LINK ND2 ASN M 88 C1 NAG M 601 1555 1555 1.44 LINK ND2 ASN M 133 C1 NAG M 602 1555 1555 1.44 LINK ND2 ASN M 156 C1 NAG i 1 1555 1555 1.44 LINK ND2 ASN M 160 C1 NAG j 1 1555 1555 1.44 LINK ND2 ASN M 197 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN M 234 C1 NAG M 603 1555 1555 1.45 LINK ND2 ASN M 241 C1 NAG M 610 1555 1555 1.44 LINK ND2 ASN M 262 C1 NAG l 1 1555 1555 1.44 LINK ND2 ASN M 276 C1 NAG M 604 1555 1555 1.44 LINK ND2 ASN M 295 C1 NAG M 605 1555 1555 1.44 LINK ND2 ASN M 301 C1 NAG M 606 1555 1555 1.44 LINK ND2 ASN M 332 C1 NAG p 1 1555 1555 1.44 LINK ND2 ASN M 339 C1 NAG M 607 1555 1555 1.45 LINK ND2 ASN M 355 C1 NAG M 608 1555 1555 1.44 LINK ND2 ASN M 363 C1 NAG m 1 1555 1555 1.44 LINK ND2 ASN M 386 C1 NAG n 1 1555 1555 1.44 LINK ND2 ASN M 392 C1 NAG M 609 1555 1555 1.44 LINK ND2 ASN M 448 C1 NAG o 1 1555 1555 1.44 LINK ND2 ASN N 611 C1 NAG N 701 1555 1555 1.44 LINK ND2 ASN N 637 C1 NAG N 702 1555 1555 1.44 LINK ND2 ASN P 72 C1 NAG P 301 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.37 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.37 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.37 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.37 LINK O4 NAG V 2 C1 BMA V 3 1555 1555 1.37 LINK O3 BMA V 3 C1 MAN V 4 1555 1555 1.37 LINK O6 BMA V 3 C1 MAN V 6 1555 1555 1.38 LINK O2 MAN V 4 C1 MAN V 5 1555 1555 1.37 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.37 LINK O4 NAG W 2 C1 BMA W 3 1555 1555 1.37 LINK O3 BMA W 3 C1 MAN W 4 1555 1555 1.38 LINK O6 BMA W 3 C1 MAN W 5 1555 1555 1.37 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.37 LINK O4 NAG X 2 C1 BMA X 3 1555 1555 1.37 LINK O6 BMA X 3 C1 MAN X 4 1555 1555 1.37 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.37 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.37 LINK O4 NAG Z 2 C1 BMA Z 3 1555 1555 1.37 LINK O3 BMA Z 3 C1 MAN Z 4 1555 1555 1.37 LINK O6 BMA Z 3 C1 MAN Z 7 1555 1555 1.37 LINK O2 MAN Z 4 C1 MAN Z 5 1555 1555 1.37 LINK O2 MAN Z 5 C1 MAN Z 6 1555 1555 1.37 LINK O3 MAN Z 7 C1 MAN Z 8 1555 1555 1.37 LINK O6 MAN Z 7 C1 MAN Z 9 1555 1555 1.38 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.37 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.37 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.37 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.37 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.37 LINK O3 BMA d 3 C1 MAN d 4 1555 1555 1.37 LINK O6 BMA d 3 C1 MAN d 6 1555 1555 1.37 LINK O2 MAN d 4 C1 MAN d 5 1555 1555 1.37 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.38 LINK O4 NAG e 2 C1 BMA e 3 1555 1555 1.37 LINK O3 BMA e 3 C1 MAN e 4 1555 1555 1.37 LINK O6 BMA e 3 C1 MAN e 5 1555 1555 1.37 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.37 LINK O4 NAG f 2 C1 BMA f 3 1555 1555 1.37 LINK O6 BMA f 3 C1 MAN f 4 1555 1555 1.37 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.37 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.37 LINK O4 NAG h 2 C1 BMA h 3 1555 1555 1.37 LINK O3 BMA h 3 C1 MAN h 4 1555 1555 1.37 LINK O6 BMA h 3 C1 MAN h 7 1555 1555 1.38 LINK O2 MAN h 4 C1 MAN h 5 1555 1555 1.37 LINK O2 MAN h 5 C1 MAN h 6 1555 1555 1.38 LINK O3 MAN h 7 C1 MAN h 8 1555 1555 1.37 LINK O6 MAN h 7 C1 MAN h 9 1555 1555 1.37 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.37 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.38 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.38 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.38 LINK O4 NAG l 2 C1 BMA l 3 1555 1555 1.37 LINK O3 BMA l 3 C1 MAN l 4 1555 1555 1.37 LINK O6 BMA l 3 C1 MAN l 6 1555 1555 1.37 LINK O2 MAN l 4 C1 MAN l 5 1555 1555 1.37 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.37 LINK O4 NAG m 2 C1 BMA m 3 1555 1555 1.37 LINK O3 BMA m 3 C1 MAN m 4 1555 1555 1.37 LINK O6 BMA m 3 C1 MAN m 5 1555 1555 1.37 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.37 LINK O4 NAG n 2 C1 BMA n 3 1555 1555 1.37 LINK O6 BMA n 3 C1 MAN n 4 1555 1555 1.37 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.37 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.37 LINK O4 NAG p 2 C1 BMA p 3 1555 1555 1.37 LINK O3 BMA p 3 C1 MAN p 4 1555 1555 1.37 LINK O6 BMA p 3 C1 MAN p 7 1555 1555 1.37 LINK O2 MAN p 4 C1 MAN p 5 1555 1555 1.37 LINK O2 MAN p 5 C1 MAN p 6 1555 1555 1.37 LINK O3 MAN p 7 C1 MAN p 8 1555 1555 1.37 LINK O6 MAN p 7 C1 MAN p 9 1555 1555 1.38 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000