HEADER VIRAL PROTEIN/IMMUNE SYSTEM 24-APR-24 9BJ3 TITLE STRUCTURE OF THE SARS-COV-2 S 6P TRIMER COMPLEX WITH THE HUMAN TITLE 2 NEUTRALIZING ANTIBODY FAB FRAGMENT, C1596 COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, S; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: C1596 FAB HEAVY CHAIN; COMPND 8 CHAIN: C, E, H; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: C1596 LIGHT CHAIN; COMPND 12 CHAIN: D, F, L; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_COMMON: 2019-NCOV, SARS-COV-2; SOURCE 5 ORGANISM_TAXID: 2697049; SOURCE 6 GENE: S, 2; SOURCE 7 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 8 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 9 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM_CELL_LINE: EXPI293F; SOURCE 11 MOL_ID: 2; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_COMMON: HUMAN; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 18 EXPRESSION_SYSTEM_CELL_LINE: EXPI293F; SOURCE 19 MOL_ID: 3; SOURCE 20 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 21 ORGANISM_COMMON: HUMAN; SOURCE 22 ORGANISM_TAXID: 9606; SOURCE 23 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 24 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 25 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 26 EXPRESSION_SYSTEM_CELL_LINE: EXPI293F KEYWDS ANTIVIRAL PROTEIN, SARS-COV-2, ANTIBODY, VIRAL PROTEIN-IMMUNE SYSTEM KEYWDS 2 COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR A.A.RUBIO,M.E.ABERNATHY,C.O.BARNES REVDAT 1 05-MAR-25 9BJ3 0 JRNL AUTH A.A.RUBIO,C.O.BARNES JRNL TITL BISPECIFIC ANTIBODIES WITH BROAD NEUTRALIZATION POTENCY JRNL TITL 2 AGAINST SARS-COV-2 VARIANTS OF CONCERN JRNL REF TO BE PUBLISHED JRNL REFN JRNL DOI 10.1126/SCITRANSLMED.ADQ5720 REMARK 2 REMARK 2 RESOLUTION. 3.04 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, CRYOSPARC, UCSF CHIMERAX, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.040 REMARK 3 NUMBER OF PARTICLES : 362680 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9BJ3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 06-MAY-24. REMARK 100 THE DEPOSITION ID IS D_1000283113. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV-2 S 6P + C1596 FAB REMARK 245 FRAGMENTS REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 3.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 4537 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, H, L, S, G, REMARK 350 AND CHAINS: I, J, K, M, N, O, P, Q, R, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i, j, k, l, m REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 PHE A 2 REMARK 465 VAL A 3 REMARK 465 PHE A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 PRO A 9 REMARK 465 LEU A 10 REMARK 465 VAL A 11 REMARK 465 SER A 12 REMARK 465 SER A 13 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLN A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 PHE A 186 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 THR A 470 REMARK 465 GLU A 471 REMARK 465 ILE A 472 REMARK 465 TYR A 473 REMARK 465 GLN A 474 REMARK 465 ALA A 475 REMARK 465 GLY A 476 REMARK 465 SER A 477 REMARK 465 THR A 478 REMARK 465 PRO A 479 REMARK 465 CYS A 480 REMARK 465 ASN A 481 REMARK 465 GLY A 482 REMARK 465 VAL A 483 REMARK 465 GLU A 484 REMARK 465 GLY A 485 REMARK 465 PHE A 486 REMARK 465 ASN A 487 REMARK 465 CYS A 488 REMARK 465 TYR A 489 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 THR A 681 REMARK 465 ASN A 682 REMARK 465 SER A 683 REMARK 465 PRO A 684 REMARK 465 ALA A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 LYS A 854 REMARK 465 ASP A 1146 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 TYR A 1209 REMARK 465 ILE A 1210 REMARK 465 LYS A 1211 REMARK 465 TRP A 1212 REMARK 465 PRO A 1213 REMARK 465 SER A 1214 REMARK 465 GLY A 1215 REMARK 465 ARG A 1216 REMARK 465 LEU A 1217 REMARK 465 VAL A 1218 REMARK 465 PRO A 1219 REMARK 465 ARG A 1220 REMARK 465 GLY A 1221 REMARK 465 SER A 1222 REMARK 465 PRO A 1223 REMARK 465 GLY A 1224 REMARK 465 SER A 1225 REMARK 465 GLY A 1226 REMARK 465 TYR A 1227 REMARK 465 ILE A 1228 REMARK 465 PRO A 1229 REMARK 465 GLU A 1230 REMARK 465 ALA A 1231 REMARK 465 PRO A 1232 REMARK 465 ARG A 1233 REMARK 465 ASP A 1234 REMARK 465 GLY A 1235 REMARK 465 GLN A 1236 REMARK 465 ALA A 1237 REMARK 465 TYR A 1238 REMARK 465 VAL A 1239 REMARK 465 ARG A 1240 REMARK 465 LYS A 1241 REMARK 465 ASP A 1242 REMARK 465 GLY A 1243 REMARK 465 GLU A 1244 REMARK 465 TRP A 1245 REMARK 465 VAL A 1246 REMARK 465 LEU A 1247 REMARK 465 LEU A 1248 REMARK 465 SER A 1249 REMARK 465 THR A 1250 REMARK 465 PHE A 1251 REMARK 465 LEU A 1252 REMARK 465 GLY A 1253 REMARK 465 HIS A 1254 REMARK 465 HIS A 1255 REMARK 465 HIS A 1256 REMARK 465 HIS A 1257 REMARK 465 HIS A 1258 REMARK 465 HIS A 1259 REMARK 465 GLY A 1260 REMARK 465 LEU A 1261 REMARK 465 ASN A 1262 REMARK 465 ASP A 1263 REMARK 465 ILE A 1264 REMARK 465 PHE A 1265 REMARK 465 GLU A 1266 REMARK 465 ALA A 1267 REMARK 465 GLN A 1268 REMARK 465 LYS A 1269 REMARK 465 ILE A 1270 REMARK 465 GLU A 1271 REMARK 465 TRP A 1272 REMARK 465 HIS A 1273 REMARK 465 GLU A 1274 REMARK 465 MET B 1 REMARK 465 PHE B 2 REMARK 465 VAL B 3 REMARK 465 PHE B 4 REMARK 465 LEU B 5 REMARK 465 VAL B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 PRO B 9 REMARK 465 LEU B 10 REMARK 465 VAL B 11 REMARK 465 SER B 12 REMARK 465 SER B 13 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLN B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 PHE B 186 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 GLY B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 THR B 470 REMARK 465 GLU B 471 REMARK 465 ILE B 472 REMARK 465 TYR B 473 REMARK 465 GLN B 474 REMARK 465 ALA B 475 REMARK 465 GLY B 476 REMARK 465 SER B 477 REMARK 465 THR B 478 REMARK 465 PRO B 479 REMARK 465 CYS B 480 REMARK 465 ASN B 481 REMARK 465 GLY B 482 REMARK 465 VAL B 483 REMARK 465 GLU B 484 REMARK 465 GLY B 485 REMARK 465 PHE B 486 REMARK 465 ASN B 487 REMARK 465 CYS B 488 REMARK 465 TYR B 489 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 TYR B 636 REMARK 465 SER B 637 REMARK 465 THR B 638 REMARK 465 THR B 681 REMARK 465 ASN B 682 REMARK 465 SER B 683 REMARK 465 PRO B 684 REMARK 465 ALA B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 CYS B 851 REMARK 465 ALA B 852 REMARK 465 GLN B 853 REMARK 465 LYS B 854 REMARK 465 ASP B 1146 REMARK 465 SER B 1147 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 TYR B 1209 REMARK 465 ILE B 1210 REMARK 465 LYS B 1211 REMARK 465 TRP B 1212 REMARK 465 PRO B 1213 REMARK 465 SER B 1214 REMARK 465 GLY B 1215 REMARK 465 ARG B 1216 REMARK 465 LEU B 1217 REMARK 465 VAL B 1218 REMARK 465 PRO B 1219 REMARK 465 ARG B 1220 REMARK 465 GLY B 1221 REMARK 465 SER B 1222 REMARK 465 PRO B 1223 REMARK 465 GLY B 1224 REMARK 465 SER B 1225 REMARK 465 GLY B 1226 REMARK 465 TYR B 1227 REMARK 465 ILE B 1228 REMARK 465 PRO B 1229 REMARK 465 GLU B 1230 REMARK 465 ALA B 1231 REMARK 465 PRO B 1232 REMARK 465 ARG B 1233 REMARK 465 ASP B 1234 REMARK 465 GLY B 1235 REMARK 465 GLN B 1236 REMARK 465 ALA B 1237 REMARK 465 TYR B 1238 REMARK 465 VAL B 1239 REMARK 465 ARG B 1240 REMARK 465 LYS B 1241 REMARK 465 ASP B 1242 REMARK 465 GLY B 1243 REMARK 465 GLU B 1244 REMARK 465 TRP B 1245 REMARK 465 VAL B 1246 REMARK 465 LEU B 1247 REMARK 465 LEU B 1248 REMARK 465 SER B 1249 REMARK 465 THR B 1250 REMARK 465 PHE B 1251 REMARK 465 LEU B 1252 REMARK 465 GLY B 1253 REMARK 465 HIS B 1254 REMARK 465 HIS B 1255 REMARK 465 HIS B 1256 REMARK 465 HIS B 1257 REMARK 465 HIS B 1258 REMARK 465 HIS B 1259 REMARK 465 GLY B 1260 REMARK 465 LEU B 1261 REMARK 465 ASN B 1262 REMARK 465 ASP B 1263 REMARK 465 ILE B 1264 REMARK 465 PHE B 1265 REMARK 465 GLU B 1266 REMARK 465 ALA B 1267 REMARK 465 GLN B 1268 REMARK 465 LYS B 1269 REMARK 465 ILE B 1270 REMARK 465 GLU B 1271 REMARK 465 TRP B 1272 REMARK 465 HIS B 1273 REMARK 465 GLU B 1274 REMARK 465 ALA C 114 REMARK 465 SER C 115 REMARK 465 THR C 116 REMARK 465 LYS C 117 REMARK 465 GLY C 118 REMARK 465 PRO C 119 REMARK 465 SER C 120 REMARK 465 VAL C 121 REMARK 465 PHE C 122 REMARK 465 PRO C 123 REMARK 465 LEU C 124 REMARK 465 ALA C 125 REMARK 465 PRO C 126 REMARK 465 SER C 127 REMARK 465 SER C 128 REMARK 465 LYS C 129 REMARK 465 SER C 130 REMARK 465 THR C 131 REMARK 465 SER C 132 REMARK 465 GLY C 133 REMARK 465 GLY C 134 REMARK 465 THR C 135 REMARK 465 ALA C 136 REMARK 465 ALA C 137 REMARK 465 LEU C 138 REMARK 465 GLY C 139 REMARK 465 CYS C 140 REMARK 465 LEU C 141 REMARK 465 VAL C 142 REMARK 465 LYS C 143 REMARK 465 ASP C 144 REMARK 465 TYR C 145 REMARK 465 PHE C 146 REMARK 465 PRO C 147 REMARK 465 GLU C 148 REMARK 465 PRO C 149 REMARK 465 VAL C 150 REMARK 465 THR C 151 REMARK 465 VAL C 152 REMARK 465 SER C 153 REMARK 465 TRP C 154 REMARK 465 ASN C 155 REMARK 465 SER C 156 REMARK 465 GLY C 157 REMARK 465 ALA C 158 REMARK 465 LEU C 159 REMARK 465 THR C 160 REMARK 465 SER C 161 REMARK 465 GLY C 162 REMARK 465 VAL C 163 REMARK 465 HIS C 164 REMARK 465 THR C 165 REMARK 465 PHE C 166 REMARK 465 PRO C 167 REMARK 465 ALA C 168 REMARK 465 VAL C 169 REMARK 465 LEU C 170 REMARK 465 GLN C 171 REMARK 465 SER C 172 REMARK 465 SER C 173 REMARK 465 GLY C 174 REMARK 465 LEU C 175 REMARK 465 TYR C 176 REMARK 465 SER C 177 REMARK 465 LEU C 178 REMARK 465 SER C 179 REMARK 465 SER C 180 REMARK 465 VAL C 181 REMARK 465 VAL C 182 REMARK 465 THR C 183 REMARK 465 VAL C 184 REMARK 465 PRO C 185 REMARK 465 SER C 186 REMARK 465 SER C 187 REMARK 465 SER C 188 REMARK 465 LEU C 189 REMARK 465 GLY C 190 REMARK 465 THR C 191 REMARK 465 GLN C 192 REMARK 465 THR C 193 REMARK 465 TYR C 194 REMARK 465 ILE C 195 REMARK 465 CYS C 196 REMARK 465 ASN C 197 REMARK 465 VAL C 198 REMARK 465 ASN C 199 REMARK 465 HIS C 200 REMARK 465 LYS C 201 REMARK 465 PRO C 202 REMARK 465 SER C 203 REMARK 465 ASN C 204 REMARK 465 THR C 205 REMARK 465 LYS C 206 REMARK 465 VAL C 207 REMARK 465 ASP C 208 REMARK 465 LYS C 209 REMARK 465 ARG C 210 REMARK 465 VAL C 211 REMARK 465 GLU C 212 REMARK 465 PRO C 213 REMARK 465 LYS C 214 REMARK 465 SER C 215 REMARK 465 CYS C 216 REMARK 465 ASP C 217 REMARK 465 LYS C 218 REMARK 465 THR C 219 REMARK 465 HIS C 220 REMARK 465 HIS C 221 REMARK 465 HIS C 222 REMARK 465 HIS C 223 REMARK 465 HIS C 224 REMARK 465 HIS C 225 REMARK 465 ARG D 108 REMARK 465 THR D 109 REMARK 465 VAL D 110 REMARK 465 ALA D 111 REMARK 465 ALA D 112 REMARK 465 PRO D 113 REMARK 465 SER D 114 REMARK 465 VAL D 115 REMARK 465 PHE D 116 REMARK 465 ILE D 117 REMARK 465 PHE D 118 REMARK 465 PRO D 119 REMARK 465 PRO D 120 REMARK 465 SER D 121 REMARK 465 ASP D 122 REMARK 465 GLU D 123 REMARK 465 GLN D 124 REMARK 465 LEU D 125 REMARK 465 LYS D 126 REMARK 465 SER D 127 REMARK 465 GLY D 128 REMARK 465 THR D 129 REMARK 465 ALA D 130 REMARK 465 SER D 131 REMARK 465 VAL D 132 REMARK 465 VAL D 133 REMARK 465 CYS D 134 REMARK 465 LEU D 135 REMARK 465 LEU D 136 REMARK 465 ASN D 137 REMARK 465 ASN D 138 REMARK 465 PHE D 139 REMARK 465 TYR D 140 REMARK 465 PRO D 141 REMARK 465 ARG D 142 REMARK 465 GLU D 143 REMARK 465 ALA D 144 REMARK 465 LYS D 145 REMARK 465 VAL D 146 REMARK 465 GLN D 147 REMARK 465 TRP D 148 REMARK 465 LYS D 149 REMARK 465 VAL D 150 REMARK 465 ASP D 151 REMARK 465 ASN D 152 REMARK 465 ALA D 153 REMARK 465 LEU D 154 REMARK 465 GLN D 155 REMARK 465 SER D 156 REMARK 465 GLY D 157 REMARK 465 ASN D 158 REMARK 465 SER D 159 REMARK 465 GLN D 160 REMARK 465 GLU D 161 REMARK 465 SER D 162 REMARK 465 VAL D 163 REMARK 465 THR D 164 REMARK 465 GLU D 165 REMARK 465 GLN D 166 REMARK 465 ASP D 167 REMARK 465 SER D 168 REMARK 465 LYS D 169 REMARK 465 ASP D 170 REMARK 465 SER D 171 REMARK 465 THR D 172 REMARK 465 TYR D 173 REMARK 465 SER D 174 REMARK 465 LEU D 175 REMARK 465 SER D 176 REMARK 465 SER D 177 REMARK 465 THR D 178 REMARK 465 LEU D 179 REMARK 465 THR D 180 REMARK 465 LEU D 181 REMARK 465 SER D 182 REMARK 465 LYS D 183 REMARK 465 ALA D 184 REMARK 465 ASP D 185 REMARK 465 TYR D 186 REMARK 465 GLU D 187 REMARK 465 LYS D 188 REMARK 465 HIS D 189 REMARK 465 LYS D 190 REMARK 465 VAL D 191 REMARK 465 TYR D 192 REMARK 465 ALA D 193 REMARK 465 CYS D 194 REMARK 465 GLU D 195 REMARK 465 VAL D 196 REMARK 465 THR D 197 REMARK 465 HIS D 198 REMARK 465 GLN D 199 REMARK 465 GLY D 200 REMARK 465 LEU D 201 REMARK 465 SER D 202 REMARK 465 SER D 203 REMARK 465 PRO D 204 REMARK 465 VAL D 205 REMARK 465 THR D 206 REMARK 465 LYS D 207 REMARK 465 SER D 208 REMARK 465 PHE D 209 REMARK 465 ASN D 210 REMARK 465 ARG D 211 REMARK 465 GLY D 212 REMARK 465 GLU D 213 REMARK 465 CYS D 214 REMARK 465 ALA E 114 REMARK 465 SER E 115 REMARK 465 THR E 116 REMARK 465 LYS E 117 REMARK 465 GLY E 118 REMARK 465 PRO E 119 REMARK 465 SER E 120 REMARK 465 VAL E 121 REMARK 465 PHE E 122 REMARK 465 PRO E 123 REMARK 465 LEU E 124 REMARK 465 ALA E 125 REMARK 465 PRO E 126 REMARK 465 SER E 127 REMARK 465 SER E 128 REMARK 465 LYS E 129 REMARK 465 SER E 130 REMARK 465 THR E 131 REMARK 465 SER E 132 REMARK 465 GLY E 133 REMARK 465 GLY E 134 REMARK 465 THR E 135 REMARK 465 ALA E 136 REMARK 465 ALA E 137 REMARK 465 LEU E 138 REMARK 465 GLY E 139 REMARK 465 CYS E 140 REMARK 465 LEU E 141 REMARK 465 VAL E 142 REMARK 465 LYS E 143 REMARK 465 ASP E 144 REMARK 465 TYR E 145 REMARK 465 PHE E 146 REMARK 465 PRO E 147 REMARK 465 GLU E 148 REMARK 465 PRO E 149 REMARK 465 VAL E 150 REMARK 465 THR E 151 REMARK 465 VAL E 152 REMARK 465 SER E 153 REMARK 465 TRP E 154 REMARK 465 ASN E 155 REMARK 465 SER E 156 REMARK 465 GLY E 157 REMARK 465 ALA E 158 REMARK 465 LEU E 159 REMARK 465 THR E 160 REMARK 465 SER E 161 REMARK 465 GLY E 162 REMARK 465 VAL E 163 REMARK 465 HIS E 164 REMARK 465 THR E 165 REMARK 465 PHE E 166 REMARK 465 PRO E 167 REMARK 465 ALA E 168 REMARK 465 VAL E 169 REMARK 465 LEU E 170 REMARK 465 GLN E 171 REMARK 465 SER E 172 REMARK 465 SER E 173 REMARK 465 GLY E 174 REMARK 465 LEU E 175 REMARK 465 TYR E 176 REMARK 465 SER E 177 REMARK 465 LEU E 178 REMARK 465 SER E 179 REMARK 465 SER E 180 REMARK 465 VAL E 181 REMARK 465 VAL E 182 REMARK 465 THR E 183 REMARK 465 VAL E 184 REMARK 465 PRO E 185 REMARK 465 SER E 186 REMARK 465 SER E 187 REMARK 465 SER E 188 REMARK 465 LEU E 189 REMARK 465 GLY E 190 REMARK 465 THR E 191 REMARK 465 GLN E 192 REMARK 465 THR E 193 REMARK 465 TYR E 194 REMARK 465 ILE E 195 REMARK 465 CYS E 196 REMARK 465 ASN E 197 REMARK 465 VAL E 198 REMARK 465 ASN E 199 REMARK 465 HIS E 200 REMARK 465 LYS E 201 REMARK 465 PRO E 202 REMARK 465 SER E 203 REMARK 465 ASN E 204 REMARK 465 THR E 205 REMARK 465 LYS E 206 REMARK 465 VAL E 207 REMARK 465 ASP E 208 REMARK 465 LYS E 209 REMARK 465 ARG E 210 REMARK 465 VAL E 211 REMARK 465 GLU E 212 REMARK 465 PRO E 213 REMARK 465 LYS E 214 REMARK 465 SER E 215 REMARK 465 CYS E 216 REMARK 465 ASP E 217 REMARK 465 LYS E 218 REMARK 465 THR E 219 REMARK 465 HIS E 220 REMARK 465 HIS E 221 REMARK 465 HIS E 222 REMARK 465 HIS E 223 REMARK 465 HIS E 224 REMARK 465 HIS E 225 REMARK 465 ARG F 108 REMARK 465 THR F 109 REMARK 465 VAL F 110 REMARK 465 ALA F 111 REMARK 465 ALA F 112 REMARK 465 PRO F 113 REMARK 465 SER F 114 REMARK 465 VAL F 115 REMARK 465 PHE F 116 REMARK 465 ILE F 117 REMARK 465 PHE F 118 REMARK 465 PRO F 119 REMARK 465 PRO F 120 REMARK 465 SER F 121 REMARK 465 ASP F 122 REMARK 465 GLU F 123 REMARK 465 GLN F 124 REMARK 465 LEU F 125 REMARK 465 LYS F 126 REMARK 465 SER F 127 REMARK 465 GLY F 128 REMARK 465 THR F 129 REMARK 465 ALA F 130 REMARK 465 SER F 131 REMARK 465 VAL F 132 REMARK 465 VAL F 133 REMARK 465 CYS F 134 REMARK 465 LEU F 135 REMARK 465 LEU F 136 REMARK 465 ASN F 137 REMARK 465 ASN F 138 REMARK 465 PHE F 139 REMARK 465 TYR F 140 REMARK 465 PRO F 141 REMARK 465 ARG F 142 REMARK 465 GLU F 143 REMARK 465 ALA F 144 REMARK 465 LYS F 145 REMARK 465 VAL F 146 REMARK 465 GLN F 147 REMARK 465 TRP F 148 REMARK 465 LYS F 149 REMARK 465 VAL F 150 REMARK 465 ASP F 151 REMARK 465 ASN F 152 REMARK 465 ALA F 153 REMARK 465 LEU F 154 REMARK 465 GLN F 155 REMARK 465 SER F 156 REMARK 465 GLY F 157 REMARK 465 ASN F 158 REMARK 465 SER F 159 REMARK 465 GLN F 160 REMARK 465 GLU F 161 REMARK 465 SER F 162 REMARK 465 VAL F 163 REMARK 465 THR F 164 REMARK 465 GLU F 165 REMARK 465 GLN F 166 REMARK 465 ASP F 167 REMARK 465 SER F 168 REMARK 465 LYS F 169 REMARK 465 ASP F 170 REMARK 465 SER F 171 REMARK 465 THR F 172 REMARK 465 TYR F 173 REMARK 465 SER F 174 REMARK 465 LEU F 175 REMARK 465 SER F 176 REMARK 465 SER F 177 REMARK 465 THR F 178 REMARK 465 LEU F 179 REMARK 465 THR F 180 REMARK 465 LEU F 181 REMARK 465 SER F 182 REMARK 465 LYS F 183 REMARK 465 ALA F 184 REMARK 465 ASP F 185 REMARK 465 TYR F 186 REMARK 465 GLU F 187 REMARK 465 LYS F 188 REMARK 465 HIS F 189 REMARK 465 LYS F 190 REMARK 465 VAL F 191 REMARK 465 TYR F 192 REMARK 465 ALA F 193 REMARK 465 CYS F 194 REMARK 465 GLU F 195 REMARK 465 VAL F 196 REMARK 465 THR F 197 REMARK 465 HIS F 198 REMARK 465 GLN F 199 REMARK 465 GLY F 200 REMARK 465 LEU F 201 REMARK 465 SER F 202 REMARK 465 SER F 203 REMARK 465 PRO F 204 REMARK 465 VAL F 205 REMARK 465 THR F 206 REMARK 465 LYS F 207 REMARK 465 SER F 208 REMARK 465 PHE F 209 REMARK 465 ASN F 210 REMARK 465 ARG F 211 REMARK 465 GLY F 212 REMARK 465 GLU F 213 REMARK 465 CYS F 214 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 THR H 219 REMARK 465 HIS H 220 REMARK 465 HIS H 221 REMARK 465 HIS H 222 REMARK 465 HIS H 223 REMARK 465 HIS H 224 REMARK 465 HIS H 225 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 MET S 1 REMARK 465 PHE S 2 REMARK 465 VAL S 3 REMARK 465 PHE S 4 REMARK 465 LEU S 5 REMARK 465 VAL S 6 REMARK 465 LEU S 7 REMARK 465 LEU S 8 REMARK 465 PRO S 9 REMARK 465 LEU S 10 REMARK 465 VAL S 11 REMARK 465 SER S 12 REMARK 465 SER S 13 REMARK 465 THR S 73 REMARK 465 ASN S 74 REMARK 465 GLY S 75 REMARK 465 LYS S 147 REMARK 465 ASN S 148 REMARK 465 ASP S 178 REMARK 465 LEU S 179 REMARK 465 GLU S 180 REMARK 465 GLY S 181 REMARK 465 LYS S 182 REMARK 465 GLN S 183 REMARK 465 GLY S 184 REMARK 465 ASN S 185 REMARK 465 PHE S 186 REMARK 465 TYR S 248 REMARK 465 LEU S 249 REMARK 465 THR S 250 REMARK 465 PRO S 251 REMARK 465 GLY S 252 REMARK 465 ASP S 253 REMARK 465 SER S 254 REMARK 465 THR S 470 REMARK 465 GLU S 471 REMARK 465 ILE S 472 REMARK 465 TYR S 473 REMARK 465 GLN S 474 REMARK 465 ALA S 475 REMARK 465 GLY S 476 REMARK 465 SER S 477 REMARK 465 THR S 478 REMARK 465 PRO S 479 REMARK 465 CYS S 480 REMARK 465 ASN S 481 REMARK 465 GLY S 482 REMARK 465 VAL S 483 REMARK 465 GLU S 484 REMARK 465 GLY S 485 REMARK 465 PHE S 486 REMARK 465 ASN S 487 REMARK 465 CYS S 488 REMARK 465 TYR S 489 REMARK 465 ALA S 623 REMARK 465 ILE S 624 REMARK 465 HIS S 625 REMARK 465 ALA S 626 REMARK 465 ASP S 627 REMARK 465 GLN S 628 REMARK 465 LEU S 629 REMARK 465 THR S 630 REMARK 465 PRO S 631 REMARK 465 THR S 632 REMARK 465 TRP S 633 REMARK 465 ARG S 634 REMARK 465 VAL S 635 REMARK 465 TYR S 636 REMARK 465 SER S 637 REMARK 465 THR S 638 REMARK 465 THR S 681 REMARK 465 ASN S 682 REMARK 465 SER S 683 REMARK 465 PRO S 684 REMARK 465 ALA S 685 REMARK 465 SER S 686 REMARK 465 VAL S 687 REMARK 465 ALA S 688 REMARK 465 LEU S 828 REMARK 465 ALA S 829 REMARK 465 ASP S 830 REMARK 465 ALA S 831 REMARK 465 GLY S 832 REMARK 465 PHE S 833 REMARK 465 ILE S 834 REMARK 465 LYS S 835 REMARK 465 GLN S 836 REMARK 465 TYR S 837 REMARK 465 GLY S 838 REMARK 465 ASP S 839 REMARK 465 CYS S 840 REMARK 465 LEU S 841 REMARK 465 GLY S 842 REMARK 465 ASP S 843 REMARK 465 ILE S 844 REMARK 465 ALA S 845 REMARK 465 ALA S 846 REMARK 465 ARG S 847 REMARK 465 ASP S 848 REMARK 465 LEU S 849 REMARK 465 ILE S 850 REMARK 465 CYS S 851 REMARK 465 ALA S 852 REMARK 465 GLN S 853 REMARK 465 LYS S 854 REMARK 465 ASP S 1146 REMARK 465 SER S 1147 REMARK 465 PHE S 1148 REMARK 465 LYS S 1149 REMARK 465 GLU S 1150 REMARK 465 GLU S 1151 REMARK 465 LEU S 1152 REMARK 465 ASP S 1153 REMARK 465 LYS S 1154 REMARK 465 TYR S 1155 REMARK 465 PHE S 1156 REMARK 465 LYS S 1157 REMARK 465 ASN S 1158 REMARK 465 HIS S 1159 REMARK 465 THR S 1160 REMARK 465 SER S 1161 REMARK 465 PRO S 1162 REMARK 465 ASP S 1163 REMARK 465 VAL S 1164 REMARK 465 ASP S 1165 REMARK 465 LEU S 1166 REMARK 465 GLY S 1167 REMARK 465 ASP S 1168 REMARK 465 ILE S 1169 REMARK 465 SER S 1170 REMARK 465 GLY S 1171 REMARK 465 ILE S 1172 REMARK 465 ASN S 1173 REMARK 465 ALA S 1174 REMARK 465 SER S 1175 REMARK 465 VAL S 1176 REMARK 465 VAL S 1177 REMARK 465 ASN S 1178 REMARK 465 ILE S 1179 REMARK 465 GLN S 1180 REMARK 465 LYS S 1181 REMARK 465 GLU S 1182 REMARK 465 ILE S 1183 REMARK 465 ASP S 1184 REMARK 465 ARG S 1185 REMARK 465 LEU S 1186 REMARK 465 ASN S 1187 REMARK 465 GLU S 1188 REMARK 465 VAL S 1189 REMARK 465 ALA S 1190 REMARK 465 LYS S 1191 REMARK 465 ASN S 1192 REMARK 465 LEU S 1193 REMARK 465 ASN S 1194 REMARK 465 GLU S 1195 REMARK 465 SER S 1196 REMARK 465 LEU S 1197 REMARK 465 ILE S 1198 REMARK 465 ASP S 1199 REMARK 465 LEU S 1200 REMARK 465 GLN S 1201 REMARK 465 GLU S 1202 REMARK 465 LEU S 1203 REMARK 465 GLY S 1204 REMARK 465 LYS S 1205 REMARK 465 TYR S 1206 REMARK 465 GLU S 1207 REMARK 465 GLN S 1208 REMARK 465 TYR S 1209 REMARK 465 ILE S 1210 REMARK 465 LYS S 1211 REMARK 465 TRP S 1212 REMARK 465 PRO S 1213 REMARK 465 SER S 1214 REMARK 465 GLY S 1215 REMARK 465 ARG S 1216 REMARK 465 LEU S 1217 REMARK 465 VAL S 1218 REMARK 465 PRO S 1219 REMARK 465 ARG S 1220 REMARK 465 GLY S 1221 REMARK 465 SER S 1222 REMARK 465 PRO S 1223 REMARK 465 GLY S 1224 REMARK 465 SER S 1225 REMARK 465 GLY S 1226 REMARK 465 TYR S 1227 REMARK 465 ILE S 1228 REMARK 465 PRO S 1229 REMARK 465 GLU S 1230 REMARK 465 ALA S 1231 REMARK 465 PRO S 1232 REMARK 465 ARG S 1233 REMARK 465 ASP S 1234 REMARK 465 GLY S 1235 REMARK 465 GLN S 1236 REMARK 465 ALA S 1237 REMARK 465 TYR S 1238 REMARK 465 VAL S 1239 REMARK 465 ARG S 1240 REMARK 465 LYS S 1241 REMARK 465 ASP S 1242 REMARK 465 GLY S 1243 REMARK 465 GLU S 1244 REMARK 465 TRP S 1245 REMARK 465 VAL S 1246 REMARK 465 LEU S 1247 REMARK 465 LEU S 1248 REMARK 465 SER S 1249 REMARK 465 THR S 1250 REMARK 465 PHE S 1251 REMARK 465 LEU S 1252 REMARK 465 GLY S 1253 REMARK 465 HIS S 1254 REMARK 465 HIS S 1255 REMARK 465 HIS S 1256 REMARK 465 HIS S 1257 REMARK 465 HIS S 1258 REMARK 465 HIS S 1259 REMARK 465 GLY S 1260 REMARK 465 LEU S 1261 REMARK 465 ASN S 1262 REMARK 465 ASP S 1263 REMARK 465 ILE S 1264 REMARK 465 PHE S 1265 REMARK 465 GLU S 1266 REMARK 465 ALA S 1267 REMARK 465 GLN S 1268 REMARK 465 LYS S 1269 REMARK 465 ILE S 1270 REMARK 465 GLU S 1271 REMARK 465 TRP S 1272 REMARK 465 HIS S 1273 REMARK 465 GLU S 1274 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 TYR A 144 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 TYR A 145 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ASN A 149 CG OD1 ND2 REMARK 470 LYS A 150 CG CD CE NZ REMARK 470 SER A 151 OG REMARK 470 TRP A 152 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP A 152 CZ3 CH2 REMARK 470 MET A 153 CG SD CE REMARK 470 GLU A 154 CG CD OE1 OE2 REMARK 470 ARG A 346 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 378 CG CD CE NZ REMARK 470 LYS A 444 CG CD CE NZ REMARK 470 PHE A 456 CG CD1 CD2 CE1 CE2 CZ REMARK 470 ARG A 457 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 458 CG CD CE NZ REMARK 470 ASN A 460 CG OD1 ND2 REMARK 470 PHE A 464 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLU A 465 CG CD OE1 OE2 REMARK 470 ILE A 468 CG1 CG2 CD1 REMARK 470 HIS A 519 CG ND1 CD2 CE1 NE2 REMARK 470 TYR B 144 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 TYR B 145 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ASN B 149 CG OD1 ND2 REMARK 470 LYS B 150 CG CD CE NZ REMARK 470 SER B 151 OG REMARK 470 TRP B 152 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP B 152 CZ3 CH2 REMARK 470 MET B 153 CG SD CE REMARK 470 GLU B 154 CG CD OE1 OE2 REMARK 470 ARG B 346 CG CD NE CZ NH1 NH2 REMARK 470 LYS B 378 CG CD CE NZ REMARK 470 LYS B 444 CG CD CE NZ REMARK 470 PHE B 456 CG CD1 CD2 CE1 CE2 CZ REMARK 470 ARG B 457 CG CD NE CZ NH1 NH2 REMARK 470 LYS B 458 CG CD CE NZ REMARK 470 ASN B 460 CG OD1 ND2 REMARK 470 PHE B 464 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLU B 465 CG CD OE1 OE2 REMARK 470 ILE B 468 CG1 CG2 CD1 REMARK 470 HIS B 519 CG ND1 CD2 CE1 NE2 REMARK 470 GLU D 17 CG CD OE1 OE2 REMARK 470 GLU D 105 CG CD OE1 OE2 REMARK 470 GLU F 17 CG CD OE1 OE2 REMARK 470 GLU F 105 CG CD OE1 OE2 REMARK 470 GLU L 17 CG CD OE1 OE2 REMARK 470 GLU L 105 CG CD OE1 OE2 REMARK 470 TYR S 144 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 TYR S 145 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ASN S 149 CG OD1 ND2 REMARK 470 LYS S 150 CG CD CE NZ REMARK 470 SER S 151 OG REMARK 470 TRP S 152 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP S 152 CZ3 CH2 REMARK 470 MET S 153 CG SD CE REMARK 470 GLU S 154 CG CD OE1 OE2 REMARK 470 ARG S 346 CG CD NE CZ NH1 NH2 REMARK 470 LYS S 378 CG CD CE NZ REMARK 470 LYS S 444 CG CD CE NZ REMARK 470 PHE S 456 CG CD1 CD2 CE1 CE2 CZ REMARK 470 ARG S 457 CG CD NE CZ NH1 NH2 REMARK 470 LYS S 458 CG CD CE NZ REMARK 470 ASN S 460 CG OD1 ND2 REMARK 470 PHE S 464 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLU S 465 CG CD OE1 OE2 REMARK 470 ILE S 468 CG1 CG2 CD1 REMARK 470 HIS S 519 CG ND1 CD2 CE1 NE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 ND2 ASN B 282 O5 NAG V 1 2.12 REMARK 500 O VAL A 308 OG1 THR A 602 2.14 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A 166 CA - CB - SG ANGL. DEV. = 8.9 DEGREES REMARK 500 CYS A 432 CA - CB - SG ANGL. DEV. = 6.8 DEGREES REMARK 500 CYS B 166 CA - CB - SG ANGL. DEV. = 13.7 DEGREES REMARK 500 CYS B 432 CA - CB - SG ANGL. DEV. = 8.3 DEGREES REMARK 500 CYS S 166 CA - CB - SG ANGL. DEV. = 10.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLN A 23 -157.71 -146.95 REMARK 500 LEU A 24 131.81 -34.66 REMARK 500 PRO A 26 -176.48 -69.37 REMARK 500 PHE A 32 -132.80 58.40 REMARK 500 ASP A 80 111.99 -160.28 REMARK 500 THR A 95 14.76 -141.40 REMARK 500 LYS A 97 72.50 -100.82 REMARK 500 ASN A 99 77.76 -101.12 REMARK 500 THR A 124 -35.29 -130.86 REMARK 500 LEU A 244 -72.64 -83.56 REMARK 500 HIS A 245 -173.12 -178.11 REMARK 500 ALA A 264 143.50 -170.04 REMARK 500 CYS A 291 47.53 -91.82 REMARK 500 GLU A 324 -179.90 -170.31 REMARK 500 PRO A 337 75.38 -69.34 REMARK 500 ALA A 372 52.16 -92.62 REMARK 500 PHE A 377 26.71 -140.74 REMARK 500 PRO A 499 43.73 -78.17 REMARK 500 ASN A 544 14.95 56.52 REMARK 500 PRO A 561 41.33 -76.81 REMARK 500 PHE A 562 -7.63 -140.01 REMARK 500 CYS A 617 32.59 -95.28 REMARK 500 ASN A 658 -160.46 -101.98 REMARK 500 ASP A 745 46.24 34.38 REMARK 500 ASN A 824 46.45 -92.00 REMARK 500 LEU A 945 58.24 -94.55 REMARK 500 ASP A 950 -30.54 -135.66 REMARK 500 PHE A1042 -61.17 -90.79 REMARK 500 GLN A1071 64.82 61.47 REMARK 500 ASP A1084 92.64 -66.98 REMARK 500 GLU A1111 86.91 -155.40 REMARK 500 ASN A1135 -169.25 -161.93 REMARK 500 PRO A1140 42.44 -84.97 REMARK 500 GLN B 23 -158.44 -147.38 REMARK 500 LEU B 24 131.93 -35.08 REMARK 500 PRO B 26 -176.95 -69.44 REMARK 500 PHE B 32 -133.13 58.81 REMARK 500 ASP B 80 112.09 -160.59 REMARK 500 THR B 95 12.80 -141.49 REMARK 500 LYS B 97 72.43 -100.78 REMARK 500 ASN B 99 77.90 -100.37 REMARK 500 ASN B 165 72.28 51.91 REMARK 500 LEU B 244 -72.72 -83.83 REMARK 500 HIS B 245 -172.82 -178.24 REMARK 500 CYS B 291 47.45 -91.80 REMARK 500 PRO B 337 76.11 -69.70 REMARK 500 ALA B 372 52.21 -92.54 REMARK 500 SER B 399 119.91 -161.77 REMARK 500 PRO B 499 43.34 -78.16 REMARK 500 ASN B 544 14.80 56.64 REMARK 500 REMARK 500 THIS ENTRY HAS 119 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 CYS A 432 VAL A 433 -148.36 REMARK 500 ASN B 282 GLY B 283 -141.31 REMARK 500 CYS B 432 VAL B 433 -140.85 REMARK 500 CYS S 432 VAL S 433 -149.10 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-44628 RELATED DB: EMDB REMARK 900 STRUCTURE OF THE SARS-COV-2 S 6P TRIMER COMPLEX WITH THE HUMAN REMARK 900 NEUTRALIZING ANTIBODY FAB FRAGMENT, C1596 DBREF 9BJ3 A 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9BJ3 B 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9BJ3 C 1 225 PDB 9BJ3 9BJ3 1 225 DBREF 9BJ3 D 1 214 PDB 9BJ3 9BJ3 1 214 DBREF 9BJ3 E 1 225 PDB 9BJ3 9BJ3 1 225 DBREF 9BJ3 F 1 214 PDB 9BJ3 9BJ3 1 214 DBREF 9BJ3 H 1 225 PDB 9BJ3 9BJ3 1 225 DBREF 9BJ3 L 1 214 PDB 9BJ3 9BJ3 1 214 DBREF 9BJ3 S 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 SEQADV 9BJ3 A UNP P0DTC2 ARG 682 DELETION SEQADV 9BJ3 A UNP P0DTC2 ARG 683 DELETION SEQADV 9BJ3 A UNP P0DTC2 ALA 684 DELETION SEQADV 9BJ3 ALA A 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9BJ3 PRO A 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9BJ3 PRO A 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9BJ3 PRO A 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9BJ3 PRO A 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9BJ3 PRO A 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9BJ3 PRO A 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9BJ3 SER A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TYR A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLN A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TYR A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LYS A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TRP A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 THR A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PHE A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY A 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU A 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASN A 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP A 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE A 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PHE A 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU A 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA A 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLN A 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LYS A 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE A 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU A 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TRP A 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS A 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU A 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 B UNP P0DTC2 ARG 682 DELETION SEQADV 9BJ3 B UNP P0DTC2 ARG 683 DELETION SEQADV 9BJ3 B UNP P0DTC2 ALA 684 DELETION SEQADV 9BJ3 ALA B 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9BJ3 PRO B 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9BJ3 PRO B 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9BJ3 PRO B 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9BJ3 PRO B 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9BJ3 PRO B 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9BJ3 PRO B 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9BJ3 SER B 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG B 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU B 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL B 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO B 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG B 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER B 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO B 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER B 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TYR B 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE B 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO B 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU B 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA B 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO B 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG B 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP B 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLN B 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA B 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TYR B 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL B 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG B 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LYS B 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP B 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU B 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TRP B 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL B 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU B 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU B 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER B 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 THR B 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PHE B 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU B 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS B 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS B 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS B 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS B 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS B 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS B 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY B 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU B 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASN B 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP B 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE B 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PHE B 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU B 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA B 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLN B 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LYS B 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE B 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU B 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TRP B 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS B 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU B 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 S UNP P0DTC2 ARG 682 DELETION SEQADV 9BJ3 S UNP P0DTC2 ARG 683 DELETION SEQADV 9BJ3 S UNP P0DTC2 ALA 684 DELETION SEQADV 9BJ3 ALA S 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9BJ3 PRO S 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9BJ3 PRO S 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9BJ3 PRO S 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9BJ3 PRO S 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9BJ3 PRO S 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9BJ3 PRO S 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9BJ3 SER S 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG S 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU S 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL S 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO S 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG S 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER S 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO S 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER S 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TYR S 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE S 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO S 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU S 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA S 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PRO S 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG S 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP S 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLN S 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA S 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TYR S 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL S 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ARG S 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LYS S 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP S 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU S 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TRP S 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 VAL S 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU S 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU S 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 SER S 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 THR S 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PHE S 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU S 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS S 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS S 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS S 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS S 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS S 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS S 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLY S 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LEU S 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASN S 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ASP S 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE S 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 PHE S 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU S 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ALA S 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLN S 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 LYS S 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 ILE S 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU S 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 TRP S 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 HIS S 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9BJ3 GLU S 1274 UNP P0DTC2 EXPRESSION TAG SEQRES 1 A 1271 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 A 1271 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 A 1271 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 A 1271 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 A 1271 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 A 1271 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 A 1271 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 A 1271 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 A 1271 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 A 1271 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 A 1271 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 A 1271 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 A 1271 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 A 1271 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 A 1271 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 A 1271 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 A 1271 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 A 1271 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 A 1271 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 A 1271 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 A 1271 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 A 1271 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 A 1271 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 A 1271 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 A 1271 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 A 1271 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 A 1271 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 A 1271 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 A 1271 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 A 1271 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 A 1271 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 A 1271 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 A 1271 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 A 1271 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 A 1271 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 A 1271 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 A 1271 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 A 1271 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 A 1271 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 A 1271 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 A 1271 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 A 1271 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 A 1271 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 A 1271 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 A 1271 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 A 1271 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 A 1271 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 A 1271 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 A 1271 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 A 1271 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 A 1271 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 A 1271 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 A 1271 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 A 1271 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 A 1271 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 A 1271 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 A 1271 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 A 1271 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 A 1271 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 A 1271 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 A 1271 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 A 1271 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 A 1271 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 A 1271 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 A 1271 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 A 1271 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 A 1271 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 A 1271 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 A 1271 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 A 1271 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 A 1271 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 A 1271 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 A 1271 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 A 1271 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 A 1271 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 A 1271 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 A 1271 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 A 1271 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 A 1271 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 A 1271 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 A 1271 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 A 1271 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 A 1271 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 A 1271 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 A 1271 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 A 1271 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 A 1271 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 A 1271 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 A 1271 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 A 1271 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 A 1271 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 A 1271 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 A 1271 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 A 1271 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 A 1271 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 A 1271 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 A 1271 LEU GLY HIS HIS HIS HIS HIS HIS GLY LEU ASN ASP ILE SEQRES 98 A 1271 PHE GLU ALA GLN LYS ILE GLU TRP HIS GLU SEQRES 1 B 1271 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 B 1271 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 B 1271 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 B 1271 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 B 1271 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 B 1271 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 B 1271 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 B 1271 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 B 1271 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 B 1271 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 B 1271 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 B 1271 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 B 1271 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 B 1271 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 B 1271 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 B 1271 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 B 1271 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 B 1271 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 B 1271 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 B 1271 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 B 1271 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 B 1271 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 B 1271 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 B 1271 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 B 1271 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 B 1271 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 B 1271 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 B 1271 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 B 1271 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 B 1271 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 B 1271 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 B 1271 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 B 1271 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 B 1271 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 B 1271 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 B 1271 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 B 1271 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 B 1271 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 B 1271 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 B 1271 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 B 1271 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 B 1271 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 B 1271 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 B 1271 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 B 1271 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 B 1271 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 B 1271 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 B 1271 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 B 1271 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 B 1271 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 B 1271 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 B 1271 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 B 1271 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 B 1271 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 B 1271 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 B 1271 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 B 1271 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 B 1271 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 B 1271 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 B 1271 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 B 1271 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 B 1271 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 B 1271 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 B 1271 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 B 1271 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 B 1271 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 B 1271 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 B 1271 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 B 1271 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 B 1271 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 B 1271 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 B 1271 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 B 1271 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 B 1271 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 B 1271 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 B 1271 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 B 1271 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 B 1271 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 B 1271 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 B 1271 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 B 1271 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 B 1271 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 B 1271 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 B 1271 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 B 1271 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 B 1271 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 B 1271 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 B 1271 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 B 1271 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 B 1271 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 B 1271 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 B 1271 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 B 1271 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 B 1271 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 B 1271 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 B 1271 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 B 1271 LEU GLY HIS HIS HIS HIS HIS HIS GLY LEU ASN ASP ILE SEQRES 98 B 1271 PHE GLU ALA GLN LYS ILE GLU TRP HIS GLU SEQRES 1 C 240 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 C 240 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 C 240 GLY THR PHE ILE ASN TYR ALA VAL THR TRP VAL ARG GLN SEQRES 4 C 240 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE ILE SEQRES 5 C 240 PRO ILE LEU GLY ILE PRO ASN TYR ALA GLN LYS PHE GLN SEQRES 6 C 240 GLY ARG VAL THR ILE THR ALA ASP LYS SER THR SER THR SEQRES 7 C 240 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 C 240 ALA VAL TYR TYR CYS ALA ARG VAL PRO GLN ALA GLY ALA SEQRES 9 C 240 ALA GLN GLY HIS TYR TYR TYR TYR TYR GLY MET ASP VAL SEQRES 10 C 240 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 C 240 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 C 240 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 C 240 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 C 240 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 C 240 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 C 240 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 C 240 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 C 240 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS THR SEQRES 19 C 240 HIS HIS HIS HIS HIS HIS SEQRES 1 D 215 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 D 215 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 D 215 GLN SER VAL THR SER SER TYR LEU ALA TRP TYR GLN GLN SEQRES 4 D 215 LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 D 215 SER SER ARG VAL THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 D 215 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 D 215 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 D 215 TYR GLY SER SER PRO LEU THR PHE GLY GLY GLY THR LYS SEQRES 9 D 215 VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 D 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 D 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 D 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 D 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 D 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 D 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 D 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 D 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 E 240 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 E 240 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 E 240 GLY THR PHE ILE ASN TYR ALA VAL THR TRP VAL ARG GLN SEQRES 4 E 240 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE ILE SEQRES 5 E 240 PRO ILE LEU GLY ILE PRO ASN TYR ALA GLN LYS PHE GLN SEQRES 6 E 240 GLY ARG VAL THR ILE THR ALA ASP LYS SER THR SER THR SEQRES 7 E 240 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 E 240 ALA VAL TYR TYR CYS ALA ARG VAL PRO GLN ALA GLY ALA SEQRES 9 E 240 ALA GLN GLY HIS TYR TYR TYR TYR TYR GLY MET ASP VAL SEQRES 10 E 240 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 E 240 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 E 240 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 E 240 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 E 240 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 E 240 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 E 240 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 E 240 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 E 240 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS THR SEQRES 19 E 240 HIS HIS HIS HIS HIS HIS SEQRES 1 F 215 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 F 215 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 F 215 GLN SER VAL THR SER SER TYR LEU ALA TRP TYR GLN GLN SEQRES 4 F 215 LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 F 215 SER SER ARG VAL THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 F 215 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 F 215 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 F 215 TYR GLY SER SER PRO LEU THR PHE GLY GLY GLY THR LYS SEQRES 9 F 215 VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 F 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 F 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 F 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 F 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 F 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 F 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 F 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 F 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 H 240 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 240 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 H 240 GLY THR PHE ILE ASN TYR ALA VAL THR TRP VAL ARG GLN SEQRES 4 H 240 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE ILE SEQRES 5 H 240 PRO ILE LEU GLY ILE PRO ASN TYR ALA GLN LYS PHE GLN SEQRES 6 H 240 GLY ARG VAL THR ILE THR ALA ASP LYS SER THR SER THR SEQRES 7 H 240 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 H 240 ALA VAL TYR TYR CYS ALA ARG VAL PRO GLN ALA GLY ALA SEQRES 9 H 240 ALA GLN GLY HIS TYR TYR TYR TYR TYR GLY MET ASP VAL SEQRES 10 H 240 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 H 240 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 H 240 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 H 240 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 H 240 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 H 240 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 H 240 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 H 240 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 H 240 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS THR SEQRES 19 H 240 HIS HIS HIS HIS HIS HIS SEQRES 1 L 215 GLU ILE VAL LEU THR GLN SER PRO GLY THR LEU SER LEU SEQRES 2 L 215 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 L 215 GLN SER VAL THR SER SER TYR LEU ALA TRP TYR GLN GLN SEQRES 4 L 215 LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SEQRES 5 L 215 SER SER ARG VAL THR GLY ILE PRO ASP ARG PHE SER GLY SEQRES 6 L 215 SER GLY SER GLY THR ASP PHE THR LEU THR ILE SER ARG SEQRES 7 L 215 LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN SEQRES 8 L 215 TYR GLY SER SER PRO LEU THR PHE GLY GLY GLY THR LYS SEQRES 9 L 215 VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 S 1271 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 S 1271 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 S 1271 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 S 1271 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 S 1271 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 S 1271 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 S 1271 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 S 1271 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 S 1271 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 S 1271 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 S 1271 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 S 1271 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 S 1271 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 S 1271 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 S 1271 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 S 1271 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 S 1271 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 S 1271 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 S 1271 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 S 1271 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 S 1271 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 S 1271 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 S 1271 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 S 1271 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 S 1271 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 S 1271 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 S 1271 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 S 1271 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 S 1271 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 S 1271 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 S 1271 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 S 1271 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 S 1271 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 S 1271 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 S 1271 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 S 1271 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 S 1271 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 S 1271 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 S 1271 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 S 1271 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 S 1271 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 S 1271 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 S 1271 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 S 1271 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 S 1271 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 S 1271 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 S 1271 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 S 1271 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 S 1271 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 S 1271 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 S 1271 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 S 1271 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 S 1271 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 S 1271 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 S 1271 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 S 1271 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 S 1271 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 S 1271 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 S 1271 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 S 1271 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 S 1271 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 S 1271 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 S 1271 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 S 1271 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 S 1271 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 S 1271 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 S 1271 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 S 1271 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 S 1271 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 S 1271 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 S 1271 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 S 1271 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 S 1271 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 S 1271 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 S 1271 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 S 1271 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 S 1271 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 S 1271 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 S 1271 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 S 1271 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 S 1271 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 S 1271 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 S 1271 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 S 1271 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 S 1271 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 S 1271 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 S 1271 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 S 1271 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 S 1271 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 S 1271 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 S 1271 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 S 1271 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 S 1271 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 S 1271 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 S 1271 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 S 1271 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 S 1271 LEU GLY HIS HIS HIS HIS HIS HIS GLY LEU ASN ASP ILE SEQRES 98 S 1271 PHE GLU ALA GLN LYS ILE GLU TRP HIS GLU HET NAG G 1 14 HET NAG G 2 14 HET NAG I 1 14 HET NAG I 2 14 HET BMA I 3 11 HET MAN I 4 11 HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG X 1 14 HET NAG X 2 14 HET NAG Y 1 14 HET NAG Y 2 14 HET NAG Z 1 14 HET NAG Z 2 14 HET BMA Z 3 11 HET NAG a 1 14 HET NAG a 2 14 HET BMA a 3 11 HET NAG b 1 14 HET NAG b 2 14 HET NAG c 1 14 HET NAG c 2 14 HET NAG d 1 14 HET NAG d 2 14 HET NAG e 1 14 HET NAG e 2 14 HET BMA e 3 11 HET MAN e 4 11 HET NAG f 1 14 HET NAG f 2 14 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET NAG i 1 14 HET NAG i 2 14 HET NAG j 1 14 HET NAG j 2 14 HET BMA j 3 11 HET NAG k 1 14 HET NAG k 2 14 HET BMA k 3 11 HET NAG l 1 14 HET NAG l 2 14 HET NAG m 1 14 HET NAG m 2 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG S1301 14 HET NAG S1302 14 HET NAG S1303 14 HET NAG S1304 14 HET NAG S1305 14 HET NAG S1306 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 78(C8 H15 N O6) FORMUL 11 BMA 9(C6 H12 O6) FORMUL 11 MAN 3(C6 H12 O6) HELIX 1 AA1 ASP A 294 LYS A 304 1 11 HELIX 2 AA2 PHE A 338 ASN A 343 1 6 HELIX 3 AA3 TYR A 365 ASN A 370 1 6 HELIX 4 AA4 THR A 385 LEU A 390 5 6 HELIX 5 AA5 ASP A 405 ILE A 410 5 6 HELIX 6 AA6 GLY A 416 ASN A 422 1 7 HELIX 7 AA7 ASP A 737 CYS A 743 1 7 HELIX 8 AA8 SER A 746 LEU A 754 1 9 HELIX 9 AA9 GLN A 755 GLY A 757 5 3 HELIX 10 AB1 SER A 758 ALA A 783 1 26 HELIX 11 AB2 SER A 816 ASN A 824 1 9 HELIX 12 AB3 THR A 866 SER A 884 1 19 HELIX 13 AB4 TRP A 886 ALA A 890 5 5 HELIX 14 AB5 PRO A 897 GLY A 908 1 12 HELIX 15 AB6 GLN A 913 GLU A 918 1 6 HELIX 16 AB7 ASN A 919 GLY A 932 1 14 HELIX 17 AB8 LYS A 933 THR A 941 1 9 HELIX 18 AB9 PRO A 942 GLY A 946 5 5 HELIX 19 AC1 LYS A 947 GLN A 949 5 3 HELIX 20 AC2 ASP A 950 LYS A 964 1 15 HELIX 21 AC3 GLN A 965 SER A 967 5 3 HELIX 22 AC4 VAL A 976 SER A 982 1 7 HELIX 23 AC5 ASP A 985 VAL A 1033 1 49 HELIX 24 AC6 ASP B 294 LYS B 304 1 11 HELIX 25 AC7 PHE B 338 ASN B 343 1 6 HELIX 26 AC8 TYR B 365 ASN B 370 1 6 HELIX 27 AC9 THR B 385 LEU B 390 5 6 HELIX 28 AD1 ASP B 405 ILE B 410 5 6 HELIX 29 AD2 GLY B 416 ASN B 422 1 7 HELIX 30 AD3 ASP B 737 CYS B 743 1 7 HELIX 31 AD4 SER B 746 LEU B 754 1 9 HELIX 32 AD5 GLN B 755 GLY B 757 5 3 HELIX 33 AD6 SER B 758 ALA B 783 1 26 HELIX 34 AD7 SER B 816 ASN B 824 1 9 HELIX 35 AD8 THR B 866 GLY B 885 1 20 HELIX 36 AD9 TRP B 886 ALA B 890 5 5 HELIX 37 AE1 PRO B 897 GLY B 908 1 12 HELIX 38 AE2 GLN B 913 GLU B 918 1 6 HELIX 39 AE3 ASN B 919 GLY B 932 1 14 HELIX 40 AE4 LYS B 933 THR B 941 1 9 HELIX 41 AE5 PRO B 942 GLY B 946 5 5 HELIX 42 AE6 LYS B 947 GLN B 949 5 3 HELIX 43 AE7 ASP B 950 LYS B 964 1 15 HELIX 44 AE8 GLN B 965 SER B 967 5 3 HELIX 45 AE9 VAL B 976 SER B 982 1 7 HELIX 46 AF1 ASP B 985 CYS B 1032 1 48 HELIX 47 AF2 VAL D 28 SER D 31 5 4 HELIX 48 AF3 GLU D 79 PHE D 83 5 5 HELIX 49 AF4 VAL F 28 SER F 31 5 4 HELIX 50 AF5 GLU F 79 PHE F 83 5 5 HELIX 51 AF6 VAL L 28 SER L 31 5 4 HELIX 52 AF7 GLU L 79 PHE L 83 5 5 HELIX 53 AF8 ASP S 294 LYS S 304 1 11 HELIX 54 AF9 PHE S 338 ASN S 343 1 6 HELIX 55 AG1 TYR S 365 ASN S 370 1 6 HELIX 56 AG2 THR S 385 LEU S 390 5 6 HELIX 57 AG3 ASP S 405 ILE S 410 5 6 HELIX 58 AG4 GLY S 416 ASN S 422 1 7 HELIX 59 AG5 ASP S 737 CYS S 743 1 7 HELIX 60 AG6 SER S 746 LEU S 754 1 9 HELIX 61 AG7 GLN S 755 GLY S 757 5 3 HELIX 62 AG8 SER S 758 ALA S 783 1 26 HELIX 63 AG9 SER S 816 ASN S 824 1 9 HELIX 64 AH1 THR S 866 SER S 884 1 19 HELIX 65 AH2 TRP S 886 ALA S 890 5 5 HELIX 66 AH3 PRO S 897 GLY S 908 1 12 HELIX 67 AH4 GLN S 913 GLU S 918 1 6 HELIX 68 AH5 ASN S 919 GLY S 932 1 14 HELIX 69 AH6 LYS S 933 THR S 941 1 9 HELIX 70 AH7 PRO S 942 GLY S 946 5 5 HELIX 71 AH8 LYS S 947 GLN S 949 5 3 HELIX 72 AH9 ASP S 950 LYS S 964 1 15 HELIX 73 AI1 GLN S 965 SER S 967 5 3 HELIX 74 AI2 VAL S 976 SER S 982 1 7 HELIX 75 AI3 ASP S 985 CYS S 1032 1 48 SHEET 1 AA1 8 ALA A 27 ASN A 30 0 SHEET 2 AA1 8 ASN A 61 HIS A 69 -1 O TRP A 64 N ALA A 27 SHEET 3 AA1 8 ALA A 263 TYR A 269 -1 O TYR A 265 N PHE A 65 SHEET 4 AA1 8 VAL A 90 SER A 94 -1 N ALA A 93 O TYR A 266 SHEET 5 AA1 8 LEU A 189 ASN A 196 -1 O ARG A 190 N SER A 94 SHEET 6 AA1 8 PHE A 201 THR A 208 -1 O LYS A 206 N GLU A 191 SHEET 7 AA1 8 ALA A 222 LEU A 229 -1 O LEU A 226 N ILE A 203 SHEET 8 AA1 8 VAL A 36 TYR A 37 1 N VAL A 36 O LEU A 223 SHEET 1 AA2 3 ALA A 27 ASN A 30 0 SHEET 2 AA2 3 ASN A 61 HIS A 69 -1 O TRP A 64 N ALA A 27 SHEET 3 AA2 3 ARG A 78 PHE A 79 -1 O ARG A 78 N HIS A 69 SHEET 1 AA3 2 VAL A 42 PHE A 43 0 SHEET 2 AA3 2 PHE B 565 GLY B 566 1 O PHE B 565 N PHE A 43 SHEET 1 AA4 3 VAL A 47 PHE A 55 0 SHEET 2 AA4 3 GLN A 271 TYR A 279 -1 O PHE A 275 N THR A 51 SHEET 3 AA4 3 ILE A 285 ASP A 290 -1 O ASP A 287 N LYS A 278 SHEET 1 AA5 6 LEU A 84 PRO A 85 0 SHEET 2 AA5 6 ARG A 237 LEU A 242 -1 O PHE A 238 N LEU A 84 SHEET 3 AA5 6 ILE A 101 GLY A 107 -1 N GLY A 107 O ARG A 237 SHEET 4 AA5 6 SER A 116 ASN A 121 -1 O ILE A 119 N TRP A 104 SHEET 5 AA5 6 VAL A 126 PHE A 135 -1 O VAL A 127 N VAL A 120 SHEET 6 AA5 6 TYR A 160 ASN A 164 -1 O ASN A 164 N GLU A 132 SHEET 1 AA6 6 LEU A 84 PRO A 85 0 SHEET 2 AA6 6 ARG A 237 LEU A 242 -1 O PHE A 238 N LEU A 84 SHEET 3 AA6 6 ILE A 101 GLY A 107 -1 N GLY A 107 O ARG A 237 SHEET 4 AA6 6 SER A 116 ASN A 121 -1 O ILE A 119 N TRP A 104 SHEET 5 AA6 6 VAL A 126 PHE A 135 -1 O VAL A 127 N VAL A 120 SHEET 6 AA6 6 GLU A 169 SER A 172 -1 O TYR A 170 N ILE A 128 SHEET 1 AA7 2 LEU A 141 VAL A 143 0 SHEET 2 AA7 2 SER A 155 PHE A 157 -1 O GLU A 156 N GLY A 142 SHEET 1 AA8 5 GLY A 311 ARG A 319 0 SHEET 2 AA8 5 PHE A 592 THR A 599 -1 O GLY A 593 N PHE A 318 SHEET 3 AA8 5 ALA A 609 GLN A 613 -1 O ALA A 609 N ILE A 598 SHEET 4 AA8 5 GLY A 648 ILE A 651 -1 O ILE A 651 N VAL A 610 SHEET 5 AA8 5 VAL A 642 THR A 645 -1 N PHE A 643 O LEU A 650 SHEET 1 AA9 5 SER A 325 ARG A 328 0 SHEET 2 AA9 5 VAL A 539 PHE A 543 1 O ASN A 542 N ARG A 328 SHEET 3 AA9 5 LEU A 546 GLU A 554 -1 O GLY A 550 N VAL A 539 SHEET 4 AA9 5 ILE A 584 THR A 588 -1 O ASP A 586 N THR A 553 SHEET 5 AA9 5 ALA A 575 ARG A 577 -1 N VAL A 576 O LEU A 585 SHEET 1 AB1 3 LYS A 356 ILE A 358 0 SHEET 2 AB1 3 ASN A 394 ALA A 397 -1 O ALA A 397 N LYS A 356 SHEET 3 AB1 3 LEU A 513 GLU A 516 -1 O GLU A 516 N ASN A 394 SHEET 1 AB2 3 PHE A 400 ARG A 403 0 SHEET 2 AB2 3 PRO A 507 VAL A 510 -1 O VAL A 510 N PHE A 400 SHEET 3 AB2 3 ALA A 435 ASN A 437 -1 N TRP A 436 O ARG A 509 SHEET 1 AB3 2 LEU A 452 ARG A 454 0 SHEET 2 AB3 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AB4 2 PHE A 565 GLY A 566 0 SHEET 2 AB4 2 VAL S 42 PHE S 43 1 O PHE S 43 N PHE A 565 SHEET 1 AB5 4 GLU A 654 HIS A 655 0 SHEET 2 AB5 4 SER A 691 THR A 696 1 O ALA A 694 N GLU A 654 SHEET 3 AB5 4 ILE A 670 GLN A 675 -1 N SER A 673 O ILE A 693 SHEET 4 AB5 4 ILE A 664 GLY A 667 -1 N GLY A 667 O ILE A 670 SHEET 1 AB6 2 ALA A 701 GLU A 702 0 SHEET 2 AB6 2 GLN S 787 ILE S 788 1 O ILE S 788 N ALA A 701 SHEET 1 AB7 2 SER A 711 ILE A 712 0 SHEET 2 AB7 2 PHE A1075 THR A1076 -1 O PHE A1075 N ILE A 712 SHEET 1 AB8 3 ASN A 717 PRO A 728 0 SHEET 2 AB8 3 GLY A1059 ALA A1070 -1 O VAL A1068 N THR A 719 SHEET 3 AB8 3 TYR A1047 ALA A1056 -1 N GLN A1054 O VAL A1061 SHEET 1 AB9 2 THR A 734 VAL A 736 0 SHEET 2 AB9 2 LEU A 858 VAL A 860 -1 O THR A 859 N SER A 735 SHEET 1 AC1 2 GLN A 787 ILE A 788 0 SHEET 2 AC1 2 ALA B 701 GLU B 702 1 O ALA B 701 N ILE A 788 SHEET 1 AC2 4 THR A1120 VAL A1122 0 SHEET 2 AC2 4 LYS A1086 PRO A1090 -1 N PHE A1089 O PHE A1121 SHEET 3 AC2 4 ILE A1081 HIS A1083 -1 N ILE A1081 O HIS A1088 SHEET 4 AC2 4 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SHEET 1 AC3 2 VAL A1094 SER A1097 0 SHEET 2 AC3 2 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 1 AC4 8 ALA B 27 ASN B 30 0 SHEET 2 AC4 8 ASN B 61 HIS B 69 -1 O TRP B 64 N ALA B 27 SHEET 3 AC4 8 ALA B 263 TYR B 269 -1 O TYR B 265 N PHE B 65 SHEET 4 AC4 8 VAL B 90 SER B 94 -1 N TYR B 91 O GLY B 268 SHEET 5 AC4 8 LEU B 189 ASN B 196 -1 O ARG B 190 N SER B 94 SHEET 6 AC4 8 PHE B 201 THR B 208 -1 O LYS B 206 N GLU B 191 SHEET 7 AC4 8 ALA B 222 LEU B 229 -1 O LEU B 226 N ILE B 203 SHEET 8 AC4 8 VAL B 36 TYR B 37 1 N VAL B 36 O LEU B 223 SHEET 1 AC5 3 ALA B 27 ASN B 30 0 SHEET 2 AC5 3 ASN B 61 HIS B 69 -1 O TRP B 64 N ALA B 27 SHEET 3 AC5 3 ARG B 78 PHE B 79 -1 O ARG B 78 N HIS B 69 SHEET 1 AC6 2 VAL B 42 PHE B 43 0 SHEET 2 AC6 2 PHE S 565 GLY S 566 1 O PHE S 565 N PHE B 43 SHEET 1 AC7 3 VAL B 47 PHE B 55 0 SHEET 2 AC7 3 GLN B 271 TYR B 279 -1 O LEU B 277 N HIS B 49 SHEET 3 AC7 3 ILE B 285 ASP B 290 -1 O ASP B 287 N LYS B 278 SHEET 1 AC8 6 LEU B 84 PRO B 85 0 SHEET 2 AC8 6 ARG B 237 LEU B 242 -1 O PHE B 238 N LEU B 84 SHEET 3 AC8 6 ILE B 101 GLY B 107 -1 N GLY B 107 O ARG B 237 SHEET 4 AC8 6 SER B 116 ASN B 121 -1 O ILE B 119 N TRP B 104 SHEET 5 AC8 6 VAL B 126 PHE B 135 -1 O VAL B 127 N VAL B 120 SHEET 6 AC8 6 TYR B 160 ASN B 164 -1 O ASN B 164 N GLU B 132 SHEET 1 AC9 6 LEU B 84 PRO B 85 0 SHEET 2 AC9 6 ARG B 237 LEU B 242 -1 O PHE B 238 N LEU B 84 SHEET 3 AC9 6 ILE B 101 GLY B 107 -1 N GLY B 107 O ARG B 237 SHEET 4 AC9 6 SER B 116 ASN B 121 -1 O ILE B 119 N TRP B 104 SHEET 5 AC9 6 VAL B 126 PHE B 135 -1 O VAL B 127 N VAL B 120 SHEET 6 AC9 6 GLU B 169 SER B 172 -1 O TYR B 170 N ILE B 128 SHEET 1 AD1 2 LEU B 141 VAL B 143 0 SHEET 2 AD1 2 SER B 155 PHE B 157 -1 O GLU B 156 N GLY B 142 SHEET 1 AD2 5 GLY B 311 ARG B 319 0 SHEET 2 AD2 5 PHE B 592 THR B 599 -1 O GLY B 593 N PHE B 318 SHEET 3 AD2 5 ALA B 609 GLN B 613 -1 O ALA B 609 N ILE B 598 SHEET 4 AD2 5 GLY B 648 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AD2 5 VAL B 642 THR B 645 -1 N PHE B 643 O LEU B 650 SHEET 1 AD3 5 SER B 325 ARG B 328 0 SHEET 2 AD3 5 VAL B 539 PHE B 543 1 O ASN B 542 N ARG B 328 SHEET 3 AD3 5 LEU B 546 GLU B 554 -1 O GLY B 550 N VAL B 539 SHEET 4 AD3 5 ILE B 584 THR B 588 -1 O ASP B 586 N THR B 553 SHEET 5 AD3 5 ALA B 575 ARG B 577 -1 N VAL B 576 O LEU B 585 SHEET 1 AD4 3 LYS B 356 ILE B 358 0 SHEET 2 AD4 3 ASN B 394 ALA B 397 -1 O VAL B 395 N ILE B 358 SHEET 3 AD4 3 LEU B 513 GLU B 516 -1 O SER B 514 N TYR B 396 SHEET 1 AD5 3 PHE B 400 ARG B 403 0 SHEET 2 AD5 3 PRO B 507 VAL B 510 -1 O VAL B 510 N PHE B 400 SHEET 3 AD5 3 ALA B 435 ASN B 437 -1 N TRP B 436 O ARG B 509 SHEET 1 AD6 2 LEU B 452 ARG B 454 0 SHEET 2 AD6 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AD7 4 GLU B 654 HIS B 655 0 SHEET 2 AD7 4 SER B 691 THR B 696 1 O ALA B 694 N GLU B 654 SHEET 3 AD7 4 ILE B 670 GLN B 675 -1 N SER B 673 O ILE B 693 SHEET 4 AD7 4 ILE B 664 GLY B 667 -1 N GLY B 667 O ILE B 670 SHEET 1 AD8 2 SER B 711 ILE B 712 0 SHEET 2 AD8 2 PHE B1075 THR B1076 -1 O PHE B1075 N ILE B 712 SHEET 1 AD9 3 ASN B 717 PRO B 728 0 SHEET 2 AD9 3 GLY B1059 ALA B1070 -1 O VAL B1060 N LEU B 727 SHEET 3 AD9 3 TYR B1047 ALA B1056 -1 N GLN B1054 O VAL B1061 SHEET 1 AE1 2 THR B 734 VAL B 736 0 SHEET 2 AE1 2 LEU B 858 VAL B 860 -1 O THR B 859 N SER B 735 SHEET 1 AE2 2 GLN B 787 ILE B 788 0 SHEET 2 AE2 2 ALA S 701 GLU S 702 1 O ALA S 701 N ILE B 788 SHEET 1 AE3 4 THR B1120 VAL B1122 0 SHEET 2 AE3 4 LYS B1086 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AE3 4 ILE B1081 HIS B1083 -1 N ILE B1081 O HIS B1088 SHEET 4 AE3 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AE4 2 VAL B1094 SER B1097 0 SHEET 2 AE4 2 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 1 AE5 4 GLN C 3 GLN C 6 0 SHEET 2 AE5 4 VAL C 18 SER C 25 -1 O LYS C 23 N VAL C 5 SHEET 3 AE5 4 THR C 77 LEU C 82 -1 O MET C 80 N VAL C 20 SHEET 4 AE5 4 VAL C 67 ASP C 72 -1 N THR C 68 O GLU C 81 SHEET 1 AE6 6 GLU C 10 LYS C 12 0 SHEET 2 AE6 6 THR C 107 VAL C 111 1 O THR C 110 N GLU C 10 SHEET 3 AE6 6 ALA C 88 TYR C 91 -1 N ALA C 88 O VAL C 109 SHEET 4 AE6 6 VAL C 34 GLN C 39 -1 N VAL C 37 O TYR C 91 SHEET 5 AE6 6 LEU C 45 ILE C 51 -1 O ILE C 51 N VAL C 34 SHEET 6 AE6 6 ASN C 58 TYR C 59 -1 O ASN C 58 N GLY C 50 SHEET 1 AE7 2 ALA C 98 GLY C 99 0 SHEET 2 AE7 2 TYR C 100F TYR C 100G-1 O TYR C 100F N GLY C 99 SHEET 1 AE8 4 LEU D 4 THR D 5 0 SHEET 2 AE8 4 ALA D 19 ALA D 25 -1 O ARG D 24 N THR D 5 SHEET 3 AE8 4 ASP D 70 ILE D 75 -1 O LEU D 73 N LEU D 21 SHEET 4 AE8 4 PHE D 62 SER D 67 -1 N SER D 63 O THR D 74 SHEET 1 AE9 2 THR D 10 LEU D 11 0 SHEET 2 AE9 2 LYS D 103 VAL D 104 1 O LYS D 103 N LEU D 11 SHEET 1 AF1 5 SER D 53 ARG D 54 0 SHEET 2 AF1 5 ARG D 45 TYR D 49 -1 N TYR D 49 O SER D 53 SHEET 3 AF1 5 LEU D 33 GLN D 38 -1 N TRP D 35 O LEU D 47 SHEET 4 AF1 5 VAL D 85 GLN D 90 -1 O VAL D 85 N GLN D 38 SHEET 5 AF1 5 THR D 97 PHE D 98 -1 O THR D 97 N GLN D 90 SHEET 1 AF2 4 GLN E 3 GLN E 6 0 SHEET 2 AF2 4 VAL E 18 SER E 25 -1 O LYS E 23 N VAL E 5 SHEET 3 AF2 4 THR E 77 LEU E 82 -1 O MET E 80 N VAL E 20 SHEET 4 AF2 4 VAL E 67 ASP E 72 -1 N THR E 68 O GLU E 81 SHEET 1 AF3 6 GLU E 10 LYS E 12 0 SHEET 2 AF3 6 THR E 107 VAL E 111 1 O THR E 110 N GLU E 10 SHEET 3 AF3 6 ALA E 88 TYR E 91 -1 N ALA E 88 O VAL E 109 SHEET 4 AF3 6 VAL E 34 GLN E 39 -1 N VAL E 37 O TYR E 91 SHEET 5 AF3 6 LEU E 45 ILE E 51 -1 O ILE E 51 N VAL E 34 SHEET 6 AF3 6 ASN E 58 TYR E 59 -1 O ASN E 58 N GLY E 50 SHEET 1 AF4 2 ALA E 98 GLY E 99 0 SHEET 2 AF4 2 TYR E 100F TYR E 100G-1 O TYR E 100F N GLY E 99 SHEET 1 AF5 4 LEU F 4 THR F 5 0 SHEET 2 AF5 4 ALA F 19 ALA F 25 -1 O ARG F 24 N THR F 5 SHEET 3 AF5 4 ASP F 70 ILE F 75 -1 O LEU F 73 N LEU F 21 SHEET 4 AF5 4 PHE F 62 SER F 67 -1 N SER F 63 O THR F 74 SHEET 1 AF6 2 THR F 10 LEU F 11 0 SHEET 2 AF6 2 LYS F 103 VAL F 104 1 O LYS F 103 N LEU F 11 SHEET 1 AF7 5 SER F 53 ARG F 54 0 SHEET 2 AF7 5 ARG F 45 TYR F 49 -1 N TYR F 49 O SER F 53 SHEET 3 AF7 5 LEU F 33 GLN F 38 -1 N TRP F 35 O LEU F 47 SHEET 4 AF7 5 VAL F 85 GLN F 90 -1 O VAL F 85 N GLN F 38 SHEET 5 AF7 5 THR F 97 PHE F 98 -1 O THR F 97 N GLN F 90 SHEET 1 AF8 4 GLN H 3 GLN H 6 0 SHEET 2 AF8 4 VAL H 18 SER H 25 -1 O LYS H 23 N VAL H 5 SHEET 3 AF8 4 THR H 77 LEU H 82 -1 O MET H 80 N VAL H 20 SHEET 4 AF8 4 VAL H 67 ASP H 72 -1 N THR H 68 O GLU H 81 SHEET 1 AF9 6 GLU H 10 LYS H 12 0 SHEET 2 AF9 6 THR H 107 VAL H 111 1 O THR H 110 N GLU H 10 SHEET 3 AF9 6 ALA H 88 TYR H 91 -1 N ALA H 88 O VAL H 109 SHEET 4 AF9 6 VAL H 34 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AF9 6 LEU H 45 ILE H 51 -1 O ILE H 51 N VAL H 34 SHEET 6 AF9 6 ASN H 58 TYR H 59 -1 O ASN H 58 N GLY H 50 SHEET 1 AG1 2 ALA H 98 GLY H 99 0 SHEET 2 AG1 2 TYR H 100F TYR H 100G-1 O TYR H 100F N GLY H 99 SHEET 1 AG2 4 LEU L 4 THR L 5 0 SHEET 2 AG2 4 ALA L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AG2 4 ASP L 70 ILE L 75 -1 O LEU L 73 N LEU L 21 SHEET 4 AG2 4 PHE L 62 SER L 67 -1 N SER L 63 O THR L 74 SHEET 1 AG3 2 THR L 10 LEU L 11 0 SHEET 2 AG3 2 LYS L 103 VAL L 104 1 O LYS L 103 N LEU L 11 SHEET 1 AG4 5 SER L 53 ARG L 54 0 SHEET 2 AG4 5 ARG L 45 TYR L 49 -1 N TYR L 49 O SER L 53 SHEET 3 AG4 5 LEU L 33 GLN L 38 -1 N TRP L 35 O LEU L 47 SHEET 4 AG4 5 VAL L 85 GLN L 90 -1 O VAL L 85 N GLN L 38 SHEET 5 AG4 5 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AG5 8 ALA S 27 ASN S 30 0 SHEET 2 AG5 8 ASN S 61 HIS S 69 -1 O VAL S 62 N THR S 29 SHEET 3 AG5 8 ALA S 263 TYR S 269 -1 O TYR S 265 N PHE S 65 SHEET 4 AG5 8 VAL S 90 SER S 94 -1 N ALA S 93 O TYR S 266 SHEET 5 AG5 8 LEU S 189 ASN S 196 -1 O ARG S 190 N SER S 94 SHEET 6 AG5 8 PHE S 201 THR S 208 -1 O LYS S 206 N GLU S 191 SHEET 7 AG5 8 ALA S 222 LEU S 229 -1 O LEU S 226 N ILE S 203 SHEET 8 AG5 8 VAL S 36 TYR S 37 1 N VAL S 36 O LEU S 223 SHEET 1 AG6 3 ALA S 27 ASN S 30 0 SHEET 2 AG6 3 ASN S 61 HIS S 69 -1 O VAL S 62 N THR S 29 SHEET 3 AG6 3 ARG S 78 PHE S 79 -1 O ARG S 78 N HIS S 69 SHEET 1 AG7 3 VAL S 47 PHE S 55 0 SHEET 2 AG7 3 GLN S 271 TYR S 279 -1 O PHE S 275 N THR S 51 SHEET 3 AG7 3 ILE S 285 ASP S 290 -1 O ASP S 287 N LYS S 278 SHEET 1 AG8 6 LEU S 84 PRO S 85 0 SHEET 2 AG8 6 ARG S 237 LEU S 242 -1 O PHE S 238 N LEU S 84 SHEET 3 AG8 6 ILE S 101 GLY S 107 -1 N GLY S 107 O ARG S 237 SHEET 4 AG8 6 SER S 116 ASN S 121 -1 O ILE S 119 N TRP S 104 SHEET 5 AG8 6 VAL S 126 PHE S 135 -1 O VAL S 127 N VAL S 120 SHEET 6 AG8 6 TYR S 160 ASN S 164 -1 O ASN S 164 N GLU S 132 SHEET 1 AG9 6 LEU S 84 PRO S 85 0 SHEET 2 AG9 6 ARG S 237 LEU S 242 -1 O PHE S 238 N LEU S 84 SHEET 3 AG9 6 ILE S 101 GLY S 107 -1 N GLY S 107 O ARG S 237 SHEET 4 AG9 6 SER S 116 ASN S 121 -1 O ILE S 119 N TRP S 104 SHEET 5 AG9 6 VAL S 126 PHE S 135 -1 O VAL S 127 N VAL S 120 SHEET 6 AG9 6 GLU S 169 SER S 172 -1 O TYR S 170 N ILE S 128 SHEET 1 AH1 2 LEU S 141 VAL S 143 0 SHEET 2 AH1 2 SER S 155 PHE S 157 -1 O GLU S 156 N GLY S 142 SHEET 1 AH2 5 GLY S 311 ARG S 319 0 SHEET 2 AH2 5 PHE S 592 THR S 599 -1 O GLY S 593 N PHE S 318 SHEET 3 AH2 5 ALA S 609 GLN S 613 -1 O ALA S 609 N ILE S 598 SHEET 4 AH2 5 GLY S 648 ILE S 651 -1 O ILE S 651 N VAL S 610 SHEET 5 AH2 5 VAL S 642 THR S 645 -1 N PHE S 643 O LEU S 650 SHEET 1 AH3 5 SER S 325 ARG S 328 0 SHEET 2 AH3 5 VAL S 539 PHE S 543 1 O ASN S 542 N ARG S 328 SHEET 3 AH3 5 LEU S 546 THR S 553 -1 O GLY S 550 N VAL S 539 SHEET 4 AH3 5 ILE S 584 THR S 588 -1 O ASP S 586 N THR S 553 SHEET 5 AH3 5 ALA S 575 ARG S 577 -1 N VAL S 576 O LEU S 585 SHEET 1 AH4 4 LYS S 356 ILE S 358 0 SHEET 2 AH4 4 ASN S 394 ALA S 397 -1 O ALA S 397 N LYS S 356 SHEET 3 AH4 4 LEU S 513 GLU S 516 -1 O GLU S 516 N ASN S 394 SHEET 4 AH4 4 GLY S 431 CYS S 432 -1 N CYS S 432 O LEU S 513 SHEET 1 AH5 3 PHE S 400 ARG S 403 0 SHEET 2 AH5 3 PRO S 507 VAL S 510 -1 O VAL S 510 N PHE S 400 SHEET 3 AH5 3 ALA S 435 ASN S 437 -1 N TRP S 436 O ARG S 509 SHEET 1 AH6 2 LEU S 452 ARG S 454 0 SHEET 2 AH6 2 LEU S 492 SER S 494 -1 O GLN S 493 N TYR S 453 SHEET 1 AH7 4 GLU S 654 HIS S 655 0 SHEET 2 AH7 4 SER S 691 THR S 696 1 O ALA S 694 N GLU S 654 SHEET 3 AH7 4 ILE S 670 GLN S 675 -1 N SER S 673 O ILE S 693 SHEET 4 AH7 4 ILE S 664 GLY S 667 -1 N GLY S 667 O ILE S 670 SHEET 1 AH8 2 SER S 711 ILE S 712 0 SHEET 2 AH8 2 PHE S1075 THR S1076 -1 O PHE S1075 N ILE S 712 SHEET 1 AH9 3 ASN S 717 PRO S 728 0 SHEET 2 AH9 3 GLY S1059 ALA S1070 -1 O VAL S1060 N LEU S 727 SHEET 3 AH9 3 TYR S1047 ALA S1056 -1 N ALA S1056 O GLY S1059 SHEET 1 AI1 2 THR S 734 VAL S 736 0 SHEET 2 AI1 2 LEU S 858 VAL S 860 -1 O THR S 859 N SER S 735 SHEET 1 AI2 4 THR S1120 VAL S1122 0 SHEET 2 AI2 4 LYS S1086 PRO S1090 -1 N PHE S1089 O PHE S1121 SHEET 3 AI2 4 ILE S1081 HIS S1083 -1 N ILE S1081 O HIS S1088 SHEET 4 AI2 4 VAL S1133 ASN S1134 1 O VAL S1133 N CYS S1082 SHEET 1 AI3 2 VAL S1094 SER S1097 0 SHEET 2 AI3 2 TRP S1102 THR S1105 -1 O PHE S1103 N VAL S1096 SSBOND 1 CYS A 15 CYS A 136 1555 1555 2.03 SSBOND 2 CYS A 131 CYS A 166 1555 1555 2.04 SSBOND 3 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 4 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 5 CYS A 379 CYS A 432 1555 1555 2.04 SSBOND 6 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 7 CYS A 538 CYS A 590 1555 1555 2.04 SSBOND 8 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 9 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 10 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 11 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 12 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 13 CYS A 1082 CYS A 1126 1555 1555 2.04 SSBOND 14 CYS B 15 CYS B 136 1555 1555 2.03 SSBOND 15 CYS B 131 CYS B 166 1555 1555 2.04 SSBOND 16 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 17 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 18 CYS B 379 CYS B 432 1555 1555 2.04 SSBOND 19 CYS B 391 CYS B 525 1555 1555 2.03 SSBOND 20 CYS B 538 CYS B 590 1555 1555 2.04 SSBOND 21 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 22 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 23 CYS B 738 CYS B 760 1555 1555 2.03 SSBOND 24 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 25 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 26 CYS B 1082 CYS B 1126 1555 1555 2.04 SSBOND 27 CYS C 22 CYS C 92 1555 1555 2.03 SSBOND 28 CYS D 23 CYS D 88 1555 1555 2.04 SSBOND 29 CYS E 22 CYS E 92 1555 1555 2.03 SSBOND 30 CYS F 23 CYS F 88 1555 1555 2.04 SSBOND 31 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 32 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 33 CYS S 15 CYS S 136 1555 1555 2.03 SSBOND 34 CYS S 131 CYS S 166 1555 1555 2.04 SSBOND 35 CYS S 291 CYS S 301 1555 1555 2.03 SSBOND 36 CYS S 336 CYS S 361 1555 1555 2.04 SSBOND 37 CYS S 379 CYS S 432 1555 1555 2.04 SSBOND 38 CYS S 391 CYS S 525 1555 1555 2.03 SSBOND 39 CYS S 538 CYS S 590 1555 1555 2.04 SSBOND 40 CYS S 617 CYS S 649 1555 1555 2.03 SSBOND 41 CYS S 662 CYS S 671 1555 1555 2.03 SSBOND 42 CYS S 738 CYS S 760 1555 1555 2.03 SSBOND 43 CYS S 743 CYS S 749 1555 1555 2.03 SSBOND 44 CYS S 1032 CYS S 1043 1555 1555 2.03 SSBOND 45 CYS S 1082 CYS S 1126 1555 1555 2.04 LINK ND2 ASN A 61 C1 NAG A1301 1555 1555 1.43 LINK ND2 ASN A 122 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN A 165 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG I 1 1555 1555 1.44 LINK ND2 ASN A 282 C1 NAG J 1 1555 1555 1.45 LINK ND2 ASN A 331 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN A 343 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN A 603 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 657 C1 NAG A1305 1555 1555 1.40 LINK ND2 ASN A 709 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG O 1 1555 1555 1.45 LINK ND2 ASN A 801 C1 NAG P 1 1555 1555 1.46 LINK ND2 ASN A1074 C1 NAG A1306 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN A1134 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN B 61 C1 NAG B1301 1555 1555 1.44 LINK ND2 ASN B 122 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN B 165 C1 NAG B1302 1555 1555 1.46 LINK ND2 ASN B 234 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN B 282 C1 NAG V 1 1555 1555 1.45 LINK ND2 ASN B 331 C1 NAG W 1 1555 1555 1.46 LINK ND2 ASN B 343 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN B 603 C1 NAG B1303 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1304 1555 1555 1.44 LINK ND2 ASN B 657 C1 NAG B1305 1555 1555 1.43 LINK ND2 ASN B 709 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN B 717 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG a 1 1555 1555 1.45 LINK ND2 ASN B1074 C1 NAG B1306 1555 1555 1.44 LINK ND2 ASN B1098 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN S 61 C1 NAG S1301 1555 1555 1.44 LINK ND2 ASN S 122 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN S 165 C1 NAG S1302 1555 1555 1.44 LINK ND2 ASN S 234 C1 NAG e 1 1555 1555 1.45 LINK ND2 ASN S 282 C1 NAG f 1 1555 1555 1.45 LINK ND2 ASN S 331 C1 NAG g 1 1555 1555 1.44 LINK ND2 ASN S 343 C1 NAG h 1 1555 1555 1.44 LINK ND2 ASN S 603 C1 NAG S1303 1555 1555 1.45 LINK ND2 ASN S 616 C1 NAG S1304 1555 1555 1.44 LINK ND2 ASN S 657 C1 NAG S1305 1555 1555 1.44 LINK ND2 ASN S 709 C1 NAG i 1 1555 1555 1.44 LINK ND2 ASN S 717 C1 NAG j 1 1555 1555 1.44 LINK ND2 ASN S 801 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN S1074 C1 NAG S1306 1555 1555 1.44 LINK ND2 ASN S1098 C1 NAG l 1 1555 1555 1.44 LINK ND2 ASN S1134 C1 NAG m 1 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.45 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.45 LINK O4 NAG I 2 C1 BMA I 3 1555 1555 1.44 LINK O3 BMA I 3 C1 MAN I 4 1555 1555 1.44 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.45 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.46 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.43 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.45 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.44 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG Z 2 C1 BMA Z 3 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 LINK O4 NAG a 2 C1 BMA a 3 1555 1555 1.44 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.45 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.45 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.45 LINK O4 NAG e 2 C1 BMA e 3 1555 1555 1.44 LINK O3 BMA e 3 C1 MAN e 4 1555 1555 1.44 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.45 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.44 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.44 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.44 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.45 LINK O4 NAG j 2 C1 BMA j 3 1555 1555 1.44 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.46 LINK O4 NAG k 2 C1 BMA k 3 1555 1555 1.44 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.45 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.44 CISPEP 1 SER D 94 PRO D 95 0 -1.06 CISPEP 2 SER F 94 PRO F 95 0 -1.15 CISPEP 3 SER L 94 PRO L 95 0 -1.52 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000