data_9BJK
# 
_entry.id   9BJK 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.395 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BJK         pdb_00009bjk 10.2210/pdb9bjk/pdb 
WWPDB D_1000283479 ?            ?                   
EMDB  EMD-44635    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-07-17 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BJK 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Inactive mu opioid receptor bound to Nb6, naloxone and NAM' 
_pdbx_database_related.db_id          EMD-44635 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              kobilka@stanford.edu 
_pdbx_contact_author.name_first         Brian 
_pdbx_contact_author.name_last          Kobilka 
_pdbx_contact_author.name_mi            K 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5958-3990 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
;O'Brien, E.S.
;
1 0000-0002-2260-7722 
'Wang, H.'           2 0000-0003-0277-3018 
'Kaavya Krishna, K.' 3 0000-0003-2283-4033 
'Zhang, C.'          4 0000-0003-1210-9161 
'Kobilka, B.K.'      5 0000-0001-5958-3990 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nature 
_citation.journal_id_ASTM           NATUAS 
_citation.journal_id_CSD            0006 
_citation.journal_id_ISSN           1476-4687 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'A mu-opioid receptor modulator that works cooperatively with naloxone.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41586-024-07587-7 
_citation.pdbx_database_id_PubMed   38961287 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 
;O'Brien, E.S.
;
1  0000-0002-2260-7722 
primary 'Rangari, V.A.'     2  0000-0002-9721-6195 
primary 'El Daibani, A.'    3  ?                   
primary 'Eans, S.O.'        4  ?                   
primary 'Hammond, H.R.'     5  ?                   
primary 'White, E.'         6  ?                   
primary 'Wang, H.'          7  ?                   
primary 'Shiimura, Y.'      8  ?                   
primary 'Krishna Kumar, K.' 9  0000-0003-2283-4033 
primary 'Jiang, Q.'         10 ?                   
primary 'Appourchaux, K.'   11 0000-0001-9853-3347 
primary 'Huang, W.'         12 ?                   
primary 'Zhang, C.'         13 ?                   
primary 'Kennedy, B.J.'     14 0000-0003-1892-8926 
primary 'Mathiesen, J.M.'   15 ?                   
primary 'Che, T.'           16 0000-0002-1620-3027 
primary 'McLaughlin, J.P.'  17 0000-0001-9851-9342 
primary 'Majumdar, S.'      18 0000-0002-2931-3823 
primary 'Kobilka, B.K.'     19 0000-0001-5958-3990 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'kappa opioid receptor Nanobody 6' 14730.255 1 ? ? ? ? 
2 polymer     man 'Mu-type opioid receptor' 47920.734 1 ? ? ? ? 
3 non-polymer syn Naloxone 327.374   1 ? ? ? ? 
4 non-polymer syn 
'Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide' 605.746 
1 ? ? ? ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        M-OR-1,MOR-1 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRVSGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTV
YLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVSSHHHHHHEPEA
;
;MAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRVSGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTV
YLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVSSHHHHHHEPEA
;
N ? 
2 'polypeptide(L)' no no 
;MKTIIALSYIFCLVFADYKDDDDAMGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILC
KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLT
FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRLLSGSREKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTV
DRTNHQLENLEAETAPLPDIHHHHHH
;
;MKTIIALSYIFCLVFADYKDDDDAMGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILC
KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLT
FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRLLSGSREKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTV
DRTNHQLENLEAETAPLPDIHHHHHH
;
R ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 Naloxone                                                                                                                  A1APV 
4 'Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide' A1APU 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   GLN n 
1 4   VAL n 
1 5   GLN n 
1 6   LEU n 
1 7   GLN n 
1 8   GLU n 
1 9   SER n 
1 10  GLY n 
1 11  GLY n 
1 12  GLY n 
1 13  LEU n 
1 14  VAL n 
1 15  GLN n 
1 16  ALA n 
1 17  GLY n 
1 18  GLU n 
1 19  SER n 
1 20  LEU n 
1 21  ARG n 
1 22  LEU n 
1 23  SER n 
1 24  CYS n 
1 25  ALA n 
1 26  ALA n 
1 27  SER n 
1 28  GLY n 
1 29  THR n 
1 30  ILE n 
1 31  PHE n 
1 32  ARG n 
1 33  LEU n 
1 34  TYR n 
1 35  ASP n 
1 36  MET n 
1 37  GLY n 
1 38  TRP n 
1 39  TYR n 
1 40  ARG n 
1 41  ARG n 
1 42  VAL n 
1 43  SER n 
1 44  GLY n 
1 45  ASN n 
1 46  GLN n 
1 47  ARG n 
1 48  GLU n 
1 49  LEU n 
1 50  VAL n 
1 51  ALA n 
1 52  SER n 
1 53  ILE n 
1 54  THR n 
1 55  SER n 
1 56  GLY n 
1 57  GLY n 
1 58  SER n 
1 59  THR n 
1 60  LYS n 
1 61  TYR n 
1 62  GLY n 
1 63  ASP n 
1 64  SER n 
1 65  VAL n 
1 66  LYS n 
1 67  GLY n 
1 68  ARG n 
1 69  PHE n 
1 70  THR n 
1 71  ILE n 
1 72  SER n 
1 73  ARG n 
1 74  ASP n 
1 75  ASN n 
1 76  ALA n 
1 77  LYS n 
1 78  ASN n 
1 79  THR n 
1 80  VAL n 
1 81  TYR n 
1 82  LEU n 
1 83  GLN n 
1 84  MET n 
1 85  SER n 
1 86  SER n 
1 87  LEU n 
1 88  LYS n 
1 89  PRO n 
1 90  GLU n 
1 91  ASP n 
1 92  THR n 
1 93  ALA n 
1 94  VAL n 
1 95  TYR n 
1 96  TYR n 
1 97  CYS n 
1 98  ASN n 
1 99  ALA n 
1 100 GLU n 
1 101 TYR n 
1 102 ARG n 
1 103 THR n 
1 104 GLY n 
1 105 ILE n 
1 106 TRP n 
1 107 GLU n 
1 108 GLU n 
1 109 LEU n 
1 110 LEU n 
1 111 ASP n 
1 112 GLY n 
1 113 TRP n 
1 114 GLY n 
1 115 GLN n 
1 116 GLY n 
1 117 THR n 
1 118 GLN n 
1 119 VAL n 
1 120 THR n 
1 121 VAL n 
1 122 SER n 
1 123 SER n 
1 124 HIS n 
1 125 HIS n 
1 126 HIS n 
1 127 HIS n 
1 128 HIS n 
1 129 HIS n 
1 130 GLU n 
1 131 PRO n 
1 132 GLU n 
1 133 ALA n 
2 1   MET n 
2 2   LYS n 
2 3   THR n 
2 4   ILE n 
2 5   ILE n 
2 6   ALA n 
2 7   LEU n 
2 8   SER n 
2 9   TYR n 
2 10  ILE n 
2 11  PHE n 
2 12  CYS n 
2 13  LEU n 
2 14  VAL n 
2 15  PHE n 
2 16  ALA n 
2 17  ASP n 
2 18  TYR n 
2 19  LYS n 
2 20  ASP n 
2 21  ASP n 
2 22  ASP n 
2 23  ASP n 
2 24  ALA n 
2 25  MET n 
2 26  GLY n 
2 27  PRO n 
2 28  GLY n 
2 29  ASN n 
2 30  ILE n 
2 31  SER n 
2 32  ASP n 
2 33  CYS n 
2 34  SER n 
2 35  ASP n 
2 36  PRO n 
2 37  LEU n 
2 38  ALA n 
2 39  PRO n 
2 40  ALA n 
2 41  SER n 
2 42  CYS n 
2 43  SER n 
2 44  PRO n 
2 45  ALA n 
2 46  PRO n 
2 47  GLY n 
2 48  SER n 
2 49  TRP n 
2 50  LEU n 
2 51  ASN n 
2 52  LEU n 
2 53  SER n 
2 54  HIS n 
2 55  VAL n 
2 56  ASP n 
2 57  GLY n 
2 58  ASN n 
2 59  GLN n 
2 60  SER n 
2 61  ASP n 
2 62  PRO n 
2 63  CYS n 
2 64  GLY n 
2 65  PRO n 
2 66  ASN n 
2 67  ARG n 
2 68  THR n 
2 69  GLY n 
2 70  LEU n 
2 71  GLY n 
2 72  GLY n 
2 73  SER n 
2 74  HIS n 
2 75  SER n 
2 76  LEU n 
2 77  CYS n 
2 78  PRO n 
2 79  GLN n 
2 80  THR n 
2 81  GLY n 
2 82  SER n 
2 83  PRO n 
2 84  SER n 
2 85  MET n 
2 86  VAL n 
2 87  THR n 
2 88  ALA n 
2 89  ILE n 
2 90  THR n 
2 91  ILE n 
2 92  MET n 
2 93  ALA n 
2 94  LEU n 
2 95  TYR n 
2 96  SER n 
2 97  ILE n 
2 98  VAL n 
2 99  CYS n 
2 100 VAL n 
2 101 VAL n 
2 102 GLY n 
2 103 LEU n 
2 104 PHE n 
2 105 GLY n 
2 106 ASN n 
2 107 PHE n 
2 108 LEU n 
2 109 VAL n 
2 110 MET n 
2 111 TYR n 
2 112 VAL n 
2 113 ILE n 
2 114 VAL n 
2 115 ARG n 
2 116 TYR n 
2 117 THR n 
2 118 LYS n 
2 119 MET n 
2 120 LYS n 
2 121 THR n 
2 122 ALA n 
2 123 THR n 
2 124 ASN n 
2 125 ILE n 
2 126 TYR n 
2 127 ILE n 
2 128 PHE n 
2 129 ASN n 
2 130 LEU n 
2 131 ALA n 
2 132 LEU n 
2 133 ALA n 
2 134 ASP n 
2 135 ALA n 
2 136 LEU n 
2 137 ALA n 
2 138 THR n 
2 139 SER n 
2 140 THR n 
2 141 LEU n 
2 142 PRO n 
2 143 PHE n 
2 144 GLN n 
2 145 SER n 
2 146 VAL n 
2 147 ASN n 
2 148 TYR n 
2 149 LEU n 
2 150 MET n 
2 151 GLY n 
2 152 THR n 
2 153 TRP n 
2 154 PRO n 
2 155 PHE n 
2 156 GLY n 
2 157 ASN n 
2 158 ILE n 
2 159 LEU n 
2 160 CYS n 
2 161 LYS n 
2 162 ILE n 
2 163 VAL n 
2 164 ILE n 
2 165 SER n 
2 166 ILE n 
2 167 ASP n 
2 168 TYR n 
2 169 TYR n 
2 170 ASN n 
2 171 MET n 
2 172 PHE n 
2 173 THR n 
2 174 SER n 
2 175 ILE n 
2 176 PHE n 
2 177 THR n 
2 178 LEU n 
2 179 CYS n 
2 180 THR n 
2 181 MET n 
2 182 SER n 
2 183 VAL n 
2 184 ASP n 
2 185 ARG n 
2 186 TYR n 
2 187 ILE n 
2 188 ALA n 
2 189 VAL n 
2 190 CYS n 
2 191 HIS n 
2 192 PRO n 
2 193 VAL n 
2 194 LYS n 
2 195 ALA n 
2 196 LEU n 
2 197 ASP n 
2 198 PHE n 
2 199 ARG n 
2 200 THR n 
2 201 PRO n 
2 202 ARG n 
2 203 ASN n 
2 204 ALA n 
2 205 LYS n 
2 206 ILE n 
2 207 VAL n 
2 208 ASN n 
2 209 VAL n 
2 210 CYS n 
2 211 ASN n 
2 212 TRP n 
2 213 ILE n 
2 214 LEU n 
2 215 SER n 
2 216 SER n 
2 217 ALA n 
2 218 ILE n 
2 219 GLY n 
2 220 LEU n 
2 221 PRO n 
2 222 VAL n 
2 223 MET n 
2 224 PHE n 
2 225 MET n 
2 226 ALA n 
2 227 THR n 
2 228 THR n 
2 229 LYS n 
2 230 TYR n 
2 231 ARG n 
2 232 GLN n 
2 233 GLY n 
2 234 SER n 
2 235 ILE n 
2 236 ASP n 
2 237 CYS n 
2 238 THR n 
2 239 LEU n 
2 240 THR n 
2 241 PHE n 
2 242 SER n 
2 243 HIS n 
2 244 PRO n 
2 245 THR n 
2 246 TRP n 
2 247 TYR n 
2 248 TRP n 
2 249 GLU n 
2 250 ASN n 
2 251 LEU n 
2 252 LEU n 
2 253 LYS n 
2 254 ILE n 
2 255 CYS n 
2 256 VAL n 
2 257 PHE n 
2 258 ILE n 
2 259 PHE n 
2 260 ALA n 
2 261 PHE n 
2 262 ILE n 
2 263 MET n 
2 264 PRO n 
2 265 VAL n 
2 266 LEU n 
2 267 ILE n 
2 268 ILE n 
2 269 THR n 
2 270 VAL n 
2 271 CYS n 
2 272 TYR n 
2 273 GLY n 
2 274 LEU n 
2 275 MET n 
2 276 ILE n 
2 277 LEU n 
2 278 ARG n 
2 279 LEU n 
2 280 LYS n 
2 281 SER n 
2 282 VAL n 
2 283 ARG n 
2 284 LEU n 
2 285 LEU n 
2 286 SER n 
2 287 GLY n 
2 288 SER n 
2 289 ARG n 
2 290 GLU n 
2 291 LYS n 
2 292 ASP n 
2 293 ARG n 
2 294 ASN n 
2 295 LEU n 
2 296 ARG n 
2 297 ARG n 
2 298 ILE n 
2 299 THR n 
2 300 ARG n 
2 301 MET n 
2 302 VAL n 
2 303 LEU n 
2 304 VAL n 
2 305 VAL n 
2 306 VAL n 
2 307 ALA n 
2 308 VAL n 
2 309 PHE n 
2 310 ILE n 
2 311 VAL n 
2 312 CYS n 
2 313 TRP n 
2 314 THR n 
2 315 PRO n 
2 316 ILE n 
2 317 HIS n 
2 318 ILE n 
2 319 TYR n 
2 320 VAL n 
2 321 ILE n 
2 322 ILE n 
2 323 LYS n 
2 324 ALA n 
2 325 LEU n 
2 326 ILE n 
2 327 THR n 
2 328 ILE n 
2 329 PRO n 
2 330 GLU n 
2 331 THR n 
2 332 THR n 
2 333 PHE n 
2 334 GLN n 
2 335 THR n 
2 336 VAL n 
2 337 SER n 
2 338 TRP n 
2 339 HIS n 
2 340 PHE n 
2 341 CYS n 
2 342 ILE n 
2 343 ALA n 
2 344 LEU n 
2 345 GLY n 
2 346 TYR n 
2 347 THR n 
2 348 ASN n 
2 349 SER n 
2 350 CYS n 
2 351 LEU n 
2 352 ASN n 
2 353 PRO n 
2 354 VAL n 
2 355 LEU n 
2 356 TYR n 
2 357 ALA n 
2 358 PHE n 
2 359 LEU n 
2 360 ASP n 
2 361 GLU n 
2 362 ASN n 
2 363 PHE n 
2 364 LYS n 
2 365 ARG n 
2 366 CYS n 
2 367 PHE n 
2 368 ARG n 
2 369 GLU n 
2 370 PHE n 
2 371 CYS n 
2 372 ILE n 
2 373 PRO n 
2 374 THR n 
2 375 SER n 
2 376 SER n 
2 377 THR n 
2 378 ILE n 
2 379 GLU n 
2 380 GLN n 
2 381 GLN n 
2 382 ASN n 
2 383 SER n 
2 384 ALA n 
2 385 ARG n 
2 386 ILE n 
2 387 ARG n 
2 388 GLN n 
2 389 ASN n 
2 390 THR n 
2 391 ARG n 
2 392 GLU n 
2 393 HIS n 
2 394 PRO n 
2 395 SER n 
2 396 THR n 
2 397 ALA n 
2 398 ASN n 
2 399 THR n 
2 400 VAL n 
2 401 ASP n 
2 402 ARG n 
2 403 THR n 
2 404 ASN n 
2 405 HIS n 
2 406 GLN n 
2 407 LEU n 
2 408 GLU n 
2 409 ASN n 
2 410 LEU n 
2 411 GLU n 
2 412 ALA n 
2 413 GLU n 
2 414 THR n 
2 415 ALA n 
2 416 PRO n 
2 417 LEU n 
2 418 PRO n 
2 419 ASP n 
2 420 ILE n 
2 421 HIS n 
2 422 HIS n 
2 423 HIS n 
2 424 HIS n 
2 425 HIS n 
2 426 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 133 ?             ? ?                  ? ? ? ? ? ? 'Lama glama'   9844  ? ? ? ? ? ? ? ? 
'Escherichia coli'      562  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 426 'house mouse' ? 'Oprm1, Mor, Oprm' ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1APU non-polymer         . 
'Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide' ? 
'C36 H35 N3 O4 S' 605.746 
A1APV non-polymer         . Naloxone '3,14-dihydroxy-17-(prop-2-en-1-yl)-5alpha-4,5-epoxymorphinan-6-one' 'C19 H21 N O4'    
327.374 
ALA   'L-peptide linking' y ALANINE ?                                                                    'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ?                                                                    'C6 H15 N4 O2 1'  
175.209 
ASN   'L-peptide linking' y ASPARAGINE ?                                                                    'C4 H8 N2 O3'     
132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?                                                                    'C4 H7 N O4'      
133.103 
CYS   'L-peptide linking' y CYSTEINE ?                                                                    'C3 H7 N O2 S'    
121.158 
GLN   'L-peptide linking' y GLUTAMINE ?                                                                    'C5 H10 N2 O3'    
146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?                                                                    'C5 H9 N O4'      
147.129 
GLY   'peptide linking'   y GLYCINE ?                                                                    'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ?                                                                    'C6 H10 N3 O2 1'  
156.162 
ILE   'L-peptide linking' y ISOLEUCINE ?                                                                    'C6 H13 N O2'     
131.173 
LEU   'L-peptide linking' y LEUCINE ?                                                                    'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ?                                                                    'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ?                                                                    'C5 H11 N O2 S'   
149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?                                                                    'C9 H11 N O2'     
165.189 
PRO   'L-peptide linking' y PROLINE ?                                                                    'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ?                                                                    'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ?                                                                    'C4 H9 N O3'      
119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?                                                                    'C11 H12 N2 O2'   
204.225 
TYR   'L-peptide linking' y TYROSINE ?                                                                    'C9 H11 N O3'     
181.189 
VAL   'L-peptide linking' y VALINE ?                                                                    'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   N . n 
A 1 2   ALA 2   2   ?   ?   ?   N . n 
A 1 3   GLN 3   3   ?   ?   ?   N . n 
A 1 4   VAL 4   4   ?   ?   ?   N . n 
A 1 5   GLN 5   5   ?   ?   ?   N . n 
A 1 6   LEU 6   6   ?   ?   ?   N . n 
A 1 7   GLN 7   7   ?   ?   ?   N . n 
A 1 8   GLU 8   8   ?   ?   ?   N . n 
A 1 9   SER 9   9   ?   ?   ?   N . n 
A 1 10  GLY 10  10  ?   ?   ?   N . n 
A 1 11  GLY 11  11  ?   ?   ?   N . n 
A 1 12  GLY 12  12  ?   ?   ?   N . n 
A 1 13  LEU 13  13  ?   ?   ?   N . n 
A 1 14  VAL 14  14  ?   ?   ?   N . n 
A 1 15  GLN 15  15  ?   ?   ?   N . n 
A 1 16  ALA 16  16  ?   ?   ?   N . n 
A 1 17  GLY 17  17  ?   ?   ?   N . n 
A 1 18  GLU 18  18  ?   ?   ?   N . n 
A 1 19  SER 19  19  ?   ?   ?   N . n 
A 1 20  LEU 20  20  ?   ?   ?   N . n 
A 1 21  ARG 21  21  ?   ?   ?   N . n 
A 1 22  LEU 22  22  ?   ?   ?   N . n 
A 1 23  SER 23  23  ?   ?   ?   N . n 
A 1 24  CYS 24  24  ?   ?   ?   N . n 
A 1 25  ALA 25  25  ?   ?   ?   N . n 
A 1 26  ALA 26  26  ?   ?   ?   N . n 
A 1 27  SER 27  27  ?   ?   ?   N . n 
A 1 28  GLY 28  28  ?   ?   ?   N . n 
A 1 29  THR 29  29  29  THR THR N . n 
A 1 30  ILE 30  30  30  ILE ILE N . n 
A 1 31  PHE 31  31  31  PHE PHE N . n 
A 1 32  ARG 32  32  32  ARG ARG N . n 
A 1 33  LEU 33  33  33  LEU LEU N . n 
A 1 34  TYR 34  34  34  TYR TYR N . n 
A 1 35  ASP 35  35  35  ASP ASP N . n 
A 1 36  MET 36  36  36  MET MET N . n 
A 1 37  GLY 37  37  37  GLY GLY N . n 
A 1 38  TRP 38  38  38  TRP TRP N . n 
A 1 39  TYR 39  39  39  TYR TYR N . n 
A 1 40  ARG 40  40  40  ARG ARG N . n 
A 1 41  ARG 41  41  ?   ?   ?   N . n 
A 1 42  VAL 42  42  ?   ?   ?   N . n 
A 1 43  SER 43  43  ?   ?   ?   N . n 
A 1 44  GLY 44  44  ?   ?   ?   N . n 
A 1 45  ASN 45  45  ?   ?   ?   N . n 
A 1 46  GLN 46  46  ?   ?   ?   N . n 
A 1 47  ARG 47  47  ?   ?   ?   N . n 
A 1 48  GLU 48  48  ?   ?   ?   N . n 
A 1 49  LEU 49  49  49  LEU LEU N . n 
A 1 50  VAL 50  50  50  VAL VAL N . n 
A 1 51  ALA 51  51  51  ALA ALA N . n 
A 1 52  SER 52  52  52  SER SER N . n 
A 1 53  ILE 53  53  53  ILE ILE N . n 
A 1 54  THR 54  54  54  THR THR N . n 
A 1 55  SER 55  55  55  SER SER N . n 
A 1 56  GLY 56  56  56  GLY GLY N . n 
A 1 57  GLY 57  57  57  GLY GLY N . n 
A 1 58  SER 58  58  58  SER SER N . n 
A 1 59  THR 59  59  59  THR THR N . n 
A 1 60  LYS 60  60  60  LYS LYS N . n 
A 1 61  TYR 61  61  ?   ?   ?   N . n 
A 1 62  GLY 62  62  ?   ?   ?   N . n 
A 1 63  ASP 63  63  ?   ?   ?   N . n 
A 1 64  SER 64  64  ?   ?   ?   N . n 
A 1 65  VAL 65  65  ?   ?   ?   N . n 
A 1 66  LYS 66  66  ?   ?   ?   N . n 
A 1 67  GLY 67  67  ?   ?   ?   N . n 
A 1 68  ARG 68  68  ?   ?   ?   N . n 
A 1 69  PHE 69  69  ?   ?   ?   N . n 
A 1 70  THR 70  70  70  THR THR N . n 
A 1 71  ILE 71  71  71  ILE ILE N . n 
A 1 72  SER 72  72  72  SER SER N . n 
A 1 73  ARG 73  73  73  ARG ARG N . n 
A 1 74  ASP 74  74  74  ASP ASP N . n 
A 1 75  ASN 75  75  75  ASN ASN N . n 
A 1 76  ALA 76  76  ?   ?   ?   N . n 
A 1 77  LYS 77  77  ?   ?   ?   N . n 
A 1 78  ASN 78  78  ?   ?   ?   N . n 
A 1 79  THR 79  79  ?   ?   ?   N . n 
A 1 80  VAL 80  80  ?   ?   ?   N . n 
A 1 81  TYR 81  81  ?   ?   ?   N . n 
A 1 82  LEU 82  82  ?   ?   ?   N . n 
A 1 83  GLN 83  83  ?   ?   ?   N . n 
A 1 84  MET 84  84  ?   ?   ?   N . n 
A 1 85  SER 85  85  ?   ?   ?   N . n 
A 1 86  SER 86  86  ?   ?   ?   N . n 
A 1 87  LEU 87  87  ?   ?   ?   N . n 
A 1 88  LYS 88  88  ?   ?   ?   N . n 
A 1 89  PRO 89  89  ?   ?   ?   N . n 
A 1 90  GLU 90  90  ?   ?   ?   N . n 
A 1 91  ASP 91  91  ?   ?   ?   N . n 
A 1 92  THR 92  92  ?   ?   ?   N . n 
A 1 93  ALA 93  93  93  ALA ALA N . n 
A 1 94  VAL 94  94  94  VAL VAL N . n 
A 1 95  TYR 95  95  95  TYR TYR N . n 
A 1 96  TYR 96  96  96  TYR TYR N . n 
A 1 97  CYS 97  97  97  CYS CYS N . n 
A 1 98  ASN 98  98  98  ASN ASN N . n 
A 1 99  ALA 99  99  99  ALA ALA N . n 
A 1 100 GLU 100 100 100 GLU GLU N . n 
A 1 101 TYR 101 101 101 TYR TYR N . n 
A 1 102 ARG 102 102 102 ARG ARG N . n 
A 1 103 THR 103 103 103 THR THR N . n 
A 1 104 GLY 104 104 104 GLY GLY N . n 
A 1 105 ILE 105 105 105 ILE ILE N . n 
A 1 106 TRP 106 106 106 TRP TRP N . n 
A 1 107 GLU 107 107 107 GLU GLU N . n 
A 1 108 GLU 108 108 108 GLU GLU N . n 
A 1 109 LEU 109 109 109 LEU LEU N . n 
A 1 110 LEU 110 110 110 LEU LEU N . n 
A 1 111 ASP 111 111 111 ASP ASP N . n 
A 1 112 GLY 112 112 112 GLY GLY N . n 
A 1 113 TRP 113 113 113 TRP TRP N . n 
A 1 114 GLY 114 114 114 GLY GLY N . n 
A 1 115 GLN 115 115 ?   ?   ?   N . n 
A 1 116 GLY 116 116 ?   ?   ?   N . n 
A 1 117 THR 117 117 ?   ?   ?   N . n 
A 1 118 GLN 118 118 ?   ?   ?   N . n 
A 1 119 VAL 119 119 ?   ?   ?   N . n 
A 1 120 THR 120 120 ?   ?   ?   N . n 
A 1 121 VAL 121 121 ?   ?   ?   N . n 
A 1 122 SER 122 122 ?   ?   ?   N . n 
A 1 123 SER 123 123 ?   ?   ?   N . n 
A 1 124 HIS 124 124 ?   ?   ?   N . n 
A 1 125 HIS 125 125 ?   ?   ?   N . n 
A 1 126 HIS 126 126 ?   ?   ?   N . n 
A 1 127 HIS 127 127 ?   ?   ?   N . n 
A 1 128 HIS 128 128 ?   ?   ?   N . n 
A 1 129 HIS 129 129 ?   ?   ?   N . n 
A 1 130 GLU 130 130 ?   ?   ?   N . n 
A 1 131 PRO 131 131 ?   ?   ?   N . n 
A 1 132 GLU 132 132 ?   ?   ?   N . n 
A 1 133 ALA 133 133 ?   ?   ?   N . n 
B 2 1   MET 1   -19 ?   ?   ?   R . n 
B 2 2   LYS 2   -18 ?   ?   ?   R . n 
B 2 3   THR 3   -17 ?   ?   ?   R . n 
B 2 4   ILE 4   -16 ?   ?   ?   R . n 
B 2 5   ILE 5   -15 ?   ?   ?   R . n 
B 2 6   ALA 6   -14 ?   ?   ?   R . n 
B 2 7   LEU 7   -13 ?   ?   ?   R . n 
B 2 8   SER 8   -12 ?   ?   ?   R . n 
B 2 9   TYR 9   -11 ?   ?   ?   R . n 
B 2 10  ILE 10  -10 ?   ?   ?   R . n 
B 2 11  PHE 11  -9  ?   ?   ?   R . n 
B 2 12  CYS 12  -8  ?   ?   ?   R . n 
B 2 13  LEU 13  -7  ?   ?   ?   R . n 
B 2 14  VAL 14  -6  ?   ?   ?   R . n 
B 2 15  PHE 15  -5  ?   ?   ?   R . n 
B 2 16  ALA 16  -4  ?   ?   ?   R . n 
B 2 17  ASP 17  -3  ?   ?   ?   R . n 
B 2 18  TYR 18  -2  ?   ?   ?   R . n 
B 2 19  LYS 19  -1  ?   ?   ?   R . n 
B 2 20  ASP 20  0   ?   ?   ?   R . n 
B 2 21  ASP 21  1   ?   ?   ?   R . n 
B 2 22  ASP 22  2   ?   ?   ?   R . n 
B 2 23  ASP 23  3   ?   ?   ?   R . n 
B 2 24  ALA 24  4   ?   ?   ?   R . n 
B 2 25  MET 25  5   ?   ?   ?   R . n 
B 2 26  GLY 26  6   ?   ?   ?   R . n 
B 2 27  PRO 27  7   ?   ?   ?   R . n 
B 2 28  GLY 28  8   ?   ?   ?   R . n 
B 2 29  ASN 29  9   ?   ?   ?   R . n 
B 2 30  ILE 30  10  ?   ?   ?   R . n 
B 2 31  SER 31  11  ?   ?   ?   R . n 
B 2 32  ASP 32  12  ?   ?   ?   R . n 
B 2 33  CYS 33  13  ?   ?   ?   R . n 
B 2 34  SER 34  14  ?   ?   ?   R . n 
B 2 35  ASP 35  15  ?   ?   ?   R . n 
B 2 36  PRO 36  16  ?   ?   ?   R . n 
B 2 37  LEU 37  17  ?   ?   ?   R . n 
B 2 38  ALA 38  18  ?   ?   ?   R . n 
B 2 39  PRO 39  19  ?   ?   ?   R . n 
B 2 40  ALA 40  20  ?   ?   ?   R . n 
B 2 41  SER 41  21  ?   ?   ?   R . n 
B 2 42  CYS 42  22  ?   ?   ?   R . n 
B 2 43  SER 43  23  ?   ?   ?   R . n 
B 2 44  PRO 44  24  ?   ?   ?   R . n 
B 2 45  ALA 45  25  ?   ?   ?   R . n 
B 2 46  PRO 46  26  ?   ?   ?   R . n 
B 2 47  GLY 47  27  ?   ?   ?   R . n 
B 2 48  SER 48  28  ?   ?   ?   R . n 
B 2 49  TRP 49  29  ?   ?   ?   R . n 
B 2 50  LEU 50  30  ?   ?   ?   R . n 
B 2 51  ASN 51  31  ?   ?   ?   R . n 
B 2 52  LEU 52  32  ?   ?   ?   R . n 
B 2 53  SER 53  33  ?   ?   ?   R . n 
B 2 54  HIS 54  34  ?   ?   ?   R . n 
B 2 55  VAL 55  35  ?   ?   ?   R . n 
B 2 56  ASP 56  36  ?   ?   ?   R . n 
B 2 57  GLY 57  37  ?   ?   ?   R . n 
B 2 58  ASN 58  38  ?   ?   ?   R . n 
B 2 59  GLN 59  39  ?   ?   ?   R . n 
B 2 60  SER 60  40  ?   ?   ?   R . n 
B 2 61  ASP 61  41  ?   ?   ?   R . n 
B 2 62  PRO 62  42  ?   ?   ?   R . n 
B 2 63  CYS 63  43  ?   ?   ?   R . n 
B 2 64  GLY 64  44  ?   ?   ?   R . n 
B 2 65  PRO 65  45  ?   ?   ?   R . n 
B 2 66  ASN 66  46  ?   ?   ?   R . n 
B 2 67  ARG 67  47  ?   ?   ?   R . n 
B 2 68  THR 68  48  ?   ?   ?   R . n 
B 2 69  GLY 69  49  ?   ?   ?   R . n 
B 2 70  LEU 70  50  ?   ?   ?   R . n 
B 2 71  GLY 71  51  ?   ?   ?   R . n 
B 2 72  GLY 72  52  ?   ?   ?   R . n 
B 2 73  SER 73  53  ?   ?   ?   R . n 
B 2 74  HIS 74  54  ?   ?   ?   R . n 
B 2 75  SER 75  55  ?   ?   ?   R . n 
B 2 76  LEU 76  56  ?   ?   ?   R . n 
B 2 77  CYS 77  57  ?   ?   ?   R . n 
B 2 78  PRO 78  58  ?   ?   ?   R . n 
B 2 79  GLN 79  59  ?   ?   ?   R . n 
B 2 80  THR 80  60  ?   ?   ?   R . n 
B 2 81  GLY 81  61  ?   ?   ?   R . n 
B 2 82  SER 82  62  ?   ?   ?   R . n 
B 2 83  PRO 83  63  ?   ?   ?   R . n 
B 2 84  SER 84  64  ?   ?   ?   R . n 
B 2 85  MET 85  65  65  MET MET R . n 
B 2 86  VAL 86  66  66  VAL VAL R . n 
B 2 87  THR 87  67  67  THR THR R . n 
B 2 88  ALA 88  68  68  ALA ALA R . n 
B 2 89  ILE 89  69  69  ILE ILE R . n 
B 2 90  THR 90  70  70  THR THR R . n 
B 2 91  ILE 91  71  71  ILE ILE R . n 
B 2 92  MET 92  72  72  MET MET R . n 
B 2 93  ALA 93  73  73  ALA ALA R . n 
B 2 94  LEU 94  74  74  LEU LEU R . n 
B 2 95  TYR 95  75  75  TYR TYR R . n 
B 2 96  SER 96  76  76  SER SER R . n 
B 2 97  ILE 97  77  77  ILE ILE R . n 
B 2 98  VAL 98  78  78  VAL VAL R . n 
B 2 99  CYS 99  79  79  CYS CYS R . n 
B 2 100 VAL 100 80  80  VAL VAL R . n 
B 2 101 VAL 101 81  81  VAL VAL R . n 
B 2 102 GLY 102 82  82  GLY GLY R . n 
B 2 103 LEU 103 83  83  LEU LEU R . n 
B 2 104 PHE 104 84  84  PHE PHE R . n 
B 2 105 GLY 105 85  85  GLY GLY R . n 
B 2 106 ASN 106 86  86  ASN ASN R . n 
B 2 107 PHE 107 87  87  PHE PHE R . n 
B 2 108 LEU 108 88  88  LEU LEU R . n 
B 2 109 VAL 109 89  89  VAL VAL R . n 
B 2 110 MET 110 90  90  MET MET R . n 
B 2 111 TYR 111 91  91  TYR TYR R . n 
B 2 112 VAL 112 92  92  VAL VAL R . n 
B 2 113 ILE 113 93  93  ILE ILE R . n 
B 2 114 VAL 114 94  94  VAL VAL R . n 
B 2 115 ARG 115 95  95  ARG ARG R . n 
B 2 116 TYR 116 96  96  TYR TYR R . n 
B 2 117 THR 117 97  97  THR THR R . n 
B 2 118 LYS 118 98  98  LYS LYS R . n 
B 2 119 MET 119 99  99  MET MET R . n 
B 2 120 LYS 120 100 100 LYS LYS R . n 
B 2 121 THR 121 101 101 THR THR R . n 
B 2 122 ALA 122 102 102 ALA ALA R . n 
B 2 123 THR 123 103 103 THR THR R . n 
B 2 124 ASN 124 104 104 ASN ASN R . n 
B 2 125 ILE 125 105 105 ILE ILE R . n 
B 2 126 TYR 126 106 106 TYR TYR R . n 
B 2 127 ILE 127 107 107 ILE ILE R . n 
B 2 128 PHE 128 108 108 PHE PHE R . n 
B 2 129 ASN 129 109 109 ASN ASN R . n 
B 2 130 LEU 130 110 110 LEU LEU R . n 
B 2 131 ALA 131 111 111 ALA ALA R . n 
B 2 132 LEU 132 112 112 LEU LEU R . n 
B 2 133 ALA 133 113 113 ALA ALA R . n 
B 2 134 ASP 134 114 114 ASP ASP R . n 
B 2 135 ALA 135 115 115 ALA ALA R . n 
B 2 136 LEU 136 116 116 LEU LEU R . n 
B 2 137 ALA 137 117 117 ALA ALA R . n 
B 2 138 THR 138 118 118 THR THR R . n 
B 2 139 SER 139 119 119 SER SER R . n 
B 2 140 THR 140 120 120 THR THR R . n 
B 2 141 LEU 141 121 121 LEU LEU R . n 
B 2 142 PRO 142 122 122 PRO PRO R . n 
B 2 143 PHE 143 123 123 PHE PHE R . n 
B 2 144 GLN 144 124 124 GLN GLN R . n 
B 2 145 SER 145 125 125 SER SER R . n 
B 2 146 VAL 146 126 126 VAL VAL R . n 
B 2 147 ASN 147 127 127 ASN ASN R . n 
B 2 148 TYR 148 128 128 TYR TYR R . n 
B 2 149 LEU 149 129 129 LEU LEU R . n 
B 2 150 MET 150 130 130 MET MET R . n 
B 2 151 GLY 151 131 131 GLY GLY R . n 
B 2 152 THR 152 132 132 THR THR R . n 
B 2 153 TRP 153 133 133 TRP TRP R . n 
B 2 154 PRO 154 134 134 PRO PRO R . n 
B 2 155 PHE 155 135 135 PHE PHE R . n 
B 2 156 GLY 156 136 136 GLY GLY R . n 
B 2 157 ASN 157 137 137 ASN ASN R . n 
B 2 158 ILE 158 138 138 ILE ILE R . n 
B 2 159 LEU 159 139 139 LEU LEU R . n 
B 2 160 CYS 160 140 140 CYS CYS R . n 
B 2 161 LYS 161 141 141 LYS LYS R . n 
B 2 162 ILE 162 142 142 ILE ILE R . n 
B 2 163 VAL 163 143 143 VAL VAL R . n 
B 2 164 ILE 164 144 144 ILE ILE R . n 
B 2 165 SER 165 145 145 SER SER R . n 
B 2 166 ILE 166 146 146 ILE ILE R . n 
B 2 167 ASP 167 147 147 ASP ASP R . n 
B 2 168 TYR 168 148 148 TYR TYR R . n 
B 2 169 TYR 169 149 149 TYR TYR R . n 
B 2 170 ASN 170 150 150 ASN ASN R . n 
B 2 171 MET 171 151 151 MET MET R . n 
B 2 172 PHE 172 152 152 PHE PHE R . n 
B 2 173 THR 173 153 153 THR THR R . n 
B 2 174 SER 174 154 154 SER SER R . n 
B 2 175 ILE 175 155 155 ILE ILE R . n 
B 2 176 PHE 176 156 156 PHE PHE R . n 
B 2 177 THR 177 157 157 THR THR R . n 
B 2 178 LEU 178 158 158 LEU LEU R . n 
B 2 179 CYS 179 159 159 CYS CYS R . n 
B 2 180 THR 180 160 160 THR THR R . n 
B 2 181 MET 181 161 161 MET MET R . n 
B 2 182 SER 182 162 162 SER SER R . n 
B 2 183 VAL 183 163 163 VAL VAL R . n 
B 2 184 ASP 184 164 164 ASP ASP R . n 
B 2 185 ARG 185 165 165 ARG ARG R . n 
B 2 186 TYR 186 166 166 TYR TYR R . n 
B 2 187 ILE 187 167 167 ILE ILE R . n 
B 2 188 ALA 188 168 168 ALA ALA R . n 
B 2 189 VAL 189 169 169 VAL VAL R . n 
B 2 190 CYS 190 170 170 CYS CYS R . n 
B 2 191 HIS 191 171 171 HIS HIS R . n 
B 2 192 PRO 192 172 172 PRO PRO R . n 
B 2 193 VAL 193 173 173 VAL VAL R . n 
B 2 194 LYS 194 174 174 LYS LYS R . n 
B 2 195 ALA 195 175 175 ALA ALA R . n 
B 2 196 LEU 196 176 176 LEU LEU R . n 
B 2 197 ASP 197 177 177 ASP ASP R . n 
B 2 198 PHE 198 178 178 PHE PHE R . n 
B 2 199 ARG 199 179 179 ARG ARG R . n 
B 2 200 THR 200 180 180 THR THR R . n 
B 2 201 PRO 201 181 181 PRO PRO R . n 
B 2 202 ARG 202 182 182 ARG ARG R . n 
B 2 203 ASN 203 183 183 ASN ASN R . n 
B 2 204 ALA 204 184 184 ALA ALA R . n 
B 2 205 LYS 205 185 185 LYS LYS R . n 
B 2 206 ILE 206 186 186 ILE ILE R . n 
B 2 207 VAL 207 187 187 VAL VAL R . n 
B 2 208 ASN 208 188 188 ASN ASN R . n 
B 2 209 VAL 209 189 189 VAL VAL R . n 
B 2 210 CYS 210 190 190 CYS CYS R . n 
B 2 211 ASN 211 191 191 ASN ASN R . n 
B 2 212 TRP 212 192 192 TRP TRP R . n 
B 2 213 ILE 213 193 193 ILE ILE R . n 
B 2 214 LEU 214 194 194 LEU LEU R . n 
B 2 215 SER 215 195 195 SER SER R . n 
B 2 216 SER 216 196 196 SER SER R . n 
B 2 217 ALA 217 197 197 ALA ALA R . n 
B 2 218 ILE 218 198 198 ILE ILE R . n 
B 2 219 GLY 219 199 199 GLY GLY R . n 
B 2 220 LEU 220 200 200 LEU LEU R . n 
B 2 221 PRO 221 201 201 PRO PRO R . n 
B 2 222 VAL 222 202 202 VAL VAL R . n 
B 2 223 MET 223 203 203 MET MET R . n 
B 2 224 PHE 224 204 204 PHE PHE R . n 
B 2 225 MET 225 205 205 MET MET R . n 
B 2 226 ALA 226 206 206 ALA ALA R . n 
B 2 227 THR 227 207 207 THR THR R . n 
B 2 228 THR 228 208 208 THR THR R . n 
B 2 229 LYS 229 209 209 LYS LYS R . n 
B 2 230 TYR 230 210 210 TYR TYR R . n 
B 2 231 ARG 231 211 211 ARG ARG R . n 
B 2 232 GLN 232 212 212 GLN GLN R . n 
B 2 233 GLY 233 213 213 GLY GLY R . n 
B 2 234 SER 234 214 214 SER SER R . n 
B 2 235 ILE 235 215 215 ILE ILE R . n 
B 2 236 ASP 236 216 216 ASP ASP R . n 
B 2 237 CYS 237 217 217 CYS CYS R . n 
B 2 238 THR 238 218 218 THR THR R . n 
B 2 239 LEU 239 219 219 LEU LEU R . n 
B 2 240 THR 240 220 220 THR THR R . n 
B 2 241 PHE 241 221 221 PHE PHE R . n 
B 2 242 SER 242 222 222 SER SER R . n 
B 2 243 HIS 243 223 223 HIS HIS R . n 
B 2 244 PRO 244 224 224 PRO PRO R . n 
B 2 245 THR 245 225 225 THR THR R . n 
B 2 246 TRP 246 226 226 TRP TRP R . n 
B 2 247 TYR 247 227 227 TYR TYR R . n 
B 2 248 TRP 248 228 228 TRP TRP R . n 
B 2 249 GLU 249 229 229 GLU GLU R . n 
B 2 250 ASN 250 230 230 ASN ASN R . n 
B 2 251 LEU 251 231 231 LEU LEU R . n 
B 2 252 LEU 252 232 232 LEU LEU R . n 
B 2 253 LYS 253 233 233 LYS LYS R . n 
B 2 254 ILE 254 234 234 ILE ILE R . n 
B 2 255 CYS 255 235 235 CYS CYS R . n 
B 2 256 VAL 256 236 236 VAL VAL R . n 
B 2 257 PHE 257 237 237 PHE PHE R . n 
B 2 258 ILE 258 238 238 ILE ILE R . n 
B 2 259 PHE 259 239 239 PHE PHE R . n 
B 2 260 ALA 260 240 240 ALA ALA R . n 
B 2 261 PHE 261 241 241 PHE PHE R . n 
B 2 262 ILE 262 242 242 ILE ILE R . n 
B 2 263 MET 263 243 243 MET MET R . n 
B 2 264 PRO 264 244 244 PRO PRO R . n 
B 2 265 VAL 265 245 245 VAL VAL R . n 
B 2 266 LEU 266 246 246 LEU LEU R . n 
B 2 267 ILE 267 247 247 ILE ILE R . n 
B 2 268 ILE 268 248 248 ILE ILE R . n 
B 2 269 THR 269 249 249 THR THR R . n 
B 2 270 VAL 270 250 250 VAL VAL R . n 
B 2 271 CYS 271 251 251 CYS CYS R . n 
B 2 272 TYR 272 252 252 TYR TYR R . n 
B 2 273 GLY 273 253 253 GLY GLY R . n 
B 2 274 LEU 274 254 254 LEU LEU R . n 
B 2 275 MET 275 255 255 MET MET R . n 
B 2 276 ILE 276 256 256 ILE ILE R . n 
B 2 277 LEU 277 257 257 LEU LEU R . n 
B 2 278 ARG 278 258 258 ARG ARG R . n 
B 2 279 LEU 279 259 259 LEU LEU R . n 
B 2 280 LYS 280 260 260 LYS LYS R . n 
B 2 281 SER 281 261 261 SER SER R . n 
B 2 282 VAL 282 262 262 VAL VAL R . n 
B 2 283 ARG 283 263 263 ARG ARG R . n 
B 2 284 LEU 284 264 264 LEU LEU R . n 
B 2 285 LEU 285 265 265 LEU LEU R . n 
B 2 286 SER 286 266 266 SER SER R . n 
B 2 287 GLY 287 267 267 GLY GLY R . n 
B 2 288 SER 288 268 268 SER SER R . n 
B 2 289 ARG 289 269 269 ARG ARG R . n 
B 2 290 GLU 290 270 270 GLU GLU R . n 
B 2 291 LYS 291 271 271 LYS LYS R . n 
B 2 292 ASP 292 272 272 ASP ASP R . n 
B 2 293 ARG 293 273 273 ARG ARG R . n 
B 2 294 ASN 294 274 274 ASN ASN R . n 
B 2 295 LEU 295 275 275 LEU LEU R . n 
B 2 296 ARG 296 276 276 ARG ARG R . n 
B 2 297 ARG 297 277 277 ARG ARG R . n 
B 2 298 ILE 298 278 278 ILE ILE R . n 
B 2 299 THR 299 279 279 THR THR R . n 
B 2 300 ARG 300 280 280 ARG ARG R . n 
B 2 301 MET 301 281 281 MET MET R . n 
B 2 302 VAL 302 282 282 VAL VAL R . n 
B 2 303 LEU 303 283 283 LEU LEU R . n 
B 2 304 VAL 304 284 284 VAL VAL R . n 
B 2 305 VAL 305 285 285 VAL VAL R . n 
B 2 306 VAL 306 286 286 VAL VAL R . n 
B 2 307 ALA 307 287 287 ALA ALA R . n 
B 2 308 VAL 308 288 288 VAL VAL R . n 
B 2 309 PHE 309 289 289 PHE PHE R . n 
B 2 310 ILE 310 290 290 ILE ILE R . n 
B 2 311 VAL 311 291 291 VAL VAL R . n 
B 2 312 CYS 312 292 292 CYS CYS R . n 
B 2 313 TRP 313 293 293 TRP TRP R . n 
B 2 314 THR 314 294 294 THR THR R . n 
B 2 315 PRO 315 295 295 PRO PRO R . n 
B 2 316 ILE 316 296 296 ILE ILE R . n 
B 2 317 HIS 317 297 297 HIS HIS R . n 
B 2 318 ILE 318 298 298 ILE ILE R . n 
B 2 319 TYR 319 299 299 TYR TYR R . n 
B 2 320 VAL 320 300 300 VAL VAL R . n 
B 2 321 ILE 321 301 301 ILE ILE R . n 
B 2 322 ILE 322 302 302 ILE ILE R . n 
B 2 323 LYS 323 303 303 LYS LYS R . n 
B 2 324 ALA 324 304 304 ALA ALA R . n 
B 2 325 LEU 325 305 305 LEU LEU R . n 
B 2 326 ILE 326 306 306 ILE ILE R . n 
B 2 327 THR 327 307 307 THR THR R . n 
B 2 328 ILE 328 308 308 ILE ILE R . n 
B 2 329 PRO 329 309 309 PRO PRO R . n 
B 2 330 GLU 330 310 310 GLU GLU R . n 
B 2 331 THR 331 311 311 THR THR R . n 
B 2 332 THR 332 312 312 THR THR R . n 
B 2 333 PHE 333 313 313 PHE PHE R . n 
B 2 334 GLN 334 314 314 GLN GLN R . n 
B 2 335 THR 335 315 315 THR THR R . n 
B 2 336 VAL 336 316 316 VAL VAL R . n 
B 2 337 SER 337 317 317 SER SER R . n 
B 2 338 TRP 338 318 318 TRP TRP R . n 
B 2 339 HIS 339 319 319 HIS HIS R . n 
B 2 340 PHE 340 320 320 PHE PHE R . n 
B 2 341 CYS 341 321 321 CYS CYS R . n 
B 2 342 ILE 342 322 322 ILE ILE R . n 
B 2 343 ALA 343 323 323 ALA ALA R . n 
B 2 344 LEU 344 324 324 LEU LEU R . n 
B 2 345 GLY 345 325 325 GLY GLY R . n 
B 2 346 TYR 346 326 326 TYR TYR R . n 
B 2 347 THR 347 327 327 THR THR R . n 
B 2 348 ASN 348 328 328 ASN ASN R . n 
B 2 349 SER 349 329 329 SER SER R . n 
B 2 350 CYS 350 330 330 CYS CYS R . n 
B 2 351 LEU 351 331 331 LEU LEU R . n 
B 2 352 ASN 352 332 332 ASN ASN R . n 
B 2 353 PRO 353 333 333 PRO PRO R . n 
B 2 354 VAL 354 334 334 VAL VAL R . n 
B 2 355 LEU 355 335 335 LEU LEU R . n 
B 2 356 TYR 356 336 336 TYR TYR R . n 
B 2 357 ALA 357 337 337 ALA ALA R . n 
B 2 358 PHE 358 338 338 PHE PHE R . n 
B 2 359 LEU 359 339 339 LEU LEU R . n 
B 2 360 ASP 360 340 340 ASP ASP R . n 
B 2 361 GLU 361 341 341 GLU GLU R . n 
B 2 362 ASN 362 342 342 ASN ASN R . n 
B 2 363 PHE 363 343 343 PHE PHE R . n 
B 2 364 LYS 364 344 344 LYS LYS R . n 
B 2 365 ARG 365 345 345 ARG ARG R . n 
B 2 366 CYS 366 346 346 CYS CYS R . n 
B 2 367 PHE 367 347 347 PHE PHE R . n 
B 2 368 ARG 368 348 348 ARG ARG R . n 
B 2 369 GLU 369 349 349 GLU GLU R . n 
B 2 370 PHE 370 350 350 PHE PHE R . n 
B 2 371 CYS 371 351 ?   ?   ?   R . n 
B 2 372 ILE 372 352 ?   ?   ?   R . n 
B 2 373 PRO 373 353 ?   ?   ?   R . n 
B 2 374 THR 374 354 ?   ?   ?   R . n 
B 2 375 SER 375 355 ?   ?   ?   R . n 
B 2 376 SER 376 356 ?   ?   ?   R . n 
B 2 377 THR 377 357 ?   ?   ?   R . n 
B 2 378 ILE 378 358 ?   ?   ?   R . n 
B 2 379 GLU 379 359 ?   ?   ?   R . n 
B 2 380 GLN 380 360 ?   ?   ?   R . n 
B 2 381 GLN 381 361 ?   ?   ?   R . n 
B 2 382 ASN 382 362 ?   ?   ?   R . n 
B 2 383 SER 383 363 ?   ?   ?   R . n 
B 2 384 ALA 384 364 ?   ?   ?   R . n 
B 2 385 ARG 385 365 ?   ?   ?   R . n 
B 2 386 ILE 386 366 ?   ?   ?   R . n 
B 2 387 ARG 387 367 ?   ?   ?   R . n 
B 2 388 GLN 388 368 ?   ?   ?   R . n 
B 2 389 ASN 389 369 ?   ?   ?   R . n 
B 2 390 THR 390 370 ?   ?   ?   R . n 
B 2 391 ARG 391 371 ?   ?   ?   R . n 
B 2 392 GLU 392 372 ?   ?   ?   R . n 
B 2 393 HIS 393 373 ?   ?   ?   R . n 
B 2 394 PRO 394 374 ?   ?   ?   R . n 
B 2 395 SER 395 375 ?   ?   ?   R . n 
B 2 396 THR 396 376 ?   ?   ?   R . n 
B 2 397 ALA 397 377 ?   ?   ?   R . n 
B 2 398 ASN 398 378 ?   ?   ?   R . n 
B 2 399 THR 399 379 ?   ?   ?   R . n 
B 2 400 VAL 400 380 ?   ?   ?   R . n 
B 2 401 ASP 401 381 ?   ?   ?   R . n 
B 2 402 ARG 402 382 ?   ?   ?   R . n 
B 2 403 THR 403 383 ?   ?   ?   R . n 
B 2 404 ASN 404 384 ?   ?   ?   R . n 
B 2 405 HIS 405 385 ?   ?   ?   R . n 
B 2 406 GLN 406 386 ?   ?   ?   R . n 
B 2 407 LEU 407 387 ?   ?   ?   R . n 
B 2 408 GLU 408 388 ?   ?   ?   R . n 
B 2 409 ASN 409 389 ?   ?   ?   R . n 
B 2 410 LEU 410 390 ?   ?   ?   R . n 
B 2 411 GLU 411 391 ?   ?   ?   R . n 
B 2 412 ALA 412 392 ?   ?   ?   R . n 
B 2 413 GLU 413 393 ?   ?   ?   R . n 
B 2 414 THR 414 394 ?   ?   ?   R . n 
B 2 415 ALA 415 395 ?   ?   ?   R . n 
B 2 416 PRO 416 396 ?   ?   ?   R . n 
B 2 417 LEU 417 397 ?   ?   ?   R . n 
B 2 418 PRO 418 398 ?   ?   ?   R . n 
B 2 419 ASP 419 399 ?   ?   ?   R . n 
B 2 420 ILE 420 400 ?   ?   ?   R . n 
B 2 421 HIS 421 401 ?   ?   ?   R . n 
B 2 422 HIS 422 402 ?   ?   ?   R . n 
B 2 423 HIS 423 403 ?   ?   ?   R . n 
B 2 424 HIS 424 404 ?   ?   ?   R . n 
B 2 425 HIS 425 405 ?   ?   ?   R . n 
B 2 426 HIS 426 406 ?   ?   ?   R . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1APV 1 501 401 A1APV NAL R . 
D 4 A1APU 1 502 401 A1APU N3S R . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 N THR 29  ? OG1 ? A THR 29  OG1 
2   1 Y 1 N THR 29  ? CG2 ? A THR 29  CG2 
3   1 Y 1 N ILE 30  ? CG1 ? A ILE 30  CG1 
4   1 Y 1 N ILE 30  ? CG2 ? A ILE 30  CG2 
5   1 Y 1 N ILE 30  ? CD1 ? A ILE 30  CD1 
6   1 Y 1 N ARG 32  ? CG  ? A ARG 32  CG  
7   1 Y 1 N ARG 32  ? CD  ? A ARG 32  CD  
8   1 Y 1 N ARG 32  ? NE  ? A ARG 32  NE  
9   1 Y 1 N ARG 32  ? CZ  ? A ARG 32  CZ  
10  1 Y 1 N ARG 32  ? NH1 ? A ARG 32  NH1 
11  1 Y 1 N ARG 32  ? NH2 ? A ARG 32  NH2 
12  1 Y 1 N TYR 39  ? CG  ? A TYR 39  CG  
13  1 Y 1 N TYR 39  ? CD1 ? A TYR 39  CD1 
14  1 Y 1 N TYR 39  ? CD2 ? A TYR 39  CD2 
15  1 Y 1 N TYR 39  ? CE1 ? A TYR 39  CE1 
16  1 Y 1 N TYR 39  ? CE2 ? A TYR 39  CE2 
17  1 Y 1 N TYR 39  ? CZ  ? A TYR 39  CZ  
18  1 Y 1 N TYR 39  ? OH  ? A TYR 39  OH  
19  1 Y 1 N ARG 40  ? CG  ? A ARG 40  CG  
20  1 Y 1 N ARG 40  ? CD  ? A ARG 40  CD  
21  1 Y 1 N ARG 40  ? NE  ? A ARG 40  NE  
22  1 Y 1 N ARG 40  ? CZ  ? A ARG 40  CZ  
23  1 Y 1 N ARG 40  ? NH1 ? A ARG 40  NH1 
24  1 Y 1 N ARG 40  ? NH2 ? A ARG 40  NH2 
25  1 Y 1 N LEU 49  ? CG  ? A LEU 49  CG  
26  1 Y 1 N LEU 49  ? CD1 ? A LEU 49  CD1 
27  1 Y 1 N LEU 49  ? CD2 ? A LEU 49  CD2 
28  1 Y 1 N VAL 50  ? CG1 ? A VAL 50  CG1 
29  1 Y 1 N VAL 50  ? CG2 ? A VAL 50  CG2 
30  1 Y 1 N SER 52  ? OG  ? A SER 52  OG  
31  1 Y 1 N ILE 53  ? CG1 ? A ILE 53  CG1 
32  1 Y 1 N ILE 53  ? CG2 ? A ILE 53  CG2 
33  1 Y 1 N ILE 53  ? CD1 ? A ILE 53  CD1 
34  1 Y 1 N SER 55  ? OG  ? A SER 55  OG  
35  1 Y 1 N SER 58  ? OG  ? A SER 58  OG  
36  1 Y 1 N THR 59  ? OG1 ? A THR 59  OG1 
37  1 Y 1 N THR 59  ? CG2 ? A THR 59  CG2 
38  1 Y 1 N LYS 60  ? CG  ? A LYS 60  CG  
39  1 Y 1 N LYS 60  ? CD  ? A LYS 60  CD  
40  1 Y 1 N LYS 60  ? CE  ? A LYS 60  CE  
41  1 Y 1 N LYS 60  ? NZ  ? A LYS 60  NZ  
42  1 Y 1 N THR 70  ? OG1 ? A THR 70  OG1 
43  1 Y 1 N THR 70  ? CG2 ? A THR 70  CG2 
44  1 Y 1 N ILE 71  ? CG1 ? A ILE 71  CG1 
45  1 Y 1 N ILE 71  ? CG2 ? A ILE 71  CG2 
46  1 Y 1 N ILE 71  ? CD1 ? A ILE 71  CD1 
47  1 Y 1 N SER 72  ? OG  ? A SER 72  OG  
48  1 Y 1 N ARG 73  ? CG  ? A ARG 73  CG  
49  1 Y 1 N ARG 73  ? CD  ? A ARG 73  CD  
50  1 Y 1 N ARG 73  ? NE  ? A ARG 73  NE  
51  1 Y 1 N ARG 73  ? CZ  ? A ARG 73  CZ  
52  1 Y 1 N ARG 73  ? NH1 ? A ARG 73  NH1 
53  1 Y 1 N ARG 73  ? NH2 ? A ARG 73  NH2 
54  1 Y 1 N ASP 74  ? CG  ? A ASP 74  CG  
55  1 Y 1 N ASP 74  ? OD1 ? A ASP 74  OD1 
56  1 Y 1 N ASP 74  ? OD2 ? A ASP 74  OD2 
57  1 Y 1 N ASN 75  ? CG  ? A ASN 75  CG  
58  1 Y 1 N ASN 75  ? OD1 ? A ASN 75  OD1 
59  1 Y 1 N ASN 75  ? ND2 ? A ASN 75  ND2 
60  1 Y 1 N VAL 94  ? CG1 ? A VAL 94  CG1 
61  1 Y 1 N VAL 94  ? CG2 ? A VAL 94  CG2 
62  1 Y 1 N TYR 95  ? CG  ? A TYR 95  CG  
63  1 Y 1 N TYR 95  ? CD1 ? A TYR 95  CD1 
64  1 Y 1 N TYR 95  ? CD2 ? A TYR 95  CD2 
65  1 Y 1 N TYR 95  ? CE1 ? A TYR 95  CE1 
66  1 Y 1 N TYR 95  ? CE2 ? A TYR 95  CE2 
67  1 Y 1 N TYR 95  ? CZ  ? A TYR 95  CZ  
68  1 Y 1 N TYR 95  ? OH  ? A TYR 95  OH  
69  1 Y 1 N TYR 96  ? CG  ? A TYR 96  CG  
70  1 Y 1 N TYR 96  ? CD1 ? A TYR 96  CD1 
71  1 Y 1 N TYR 96  ? CD2 ? A TYR 96  CD2 
72  1 Y 1 N TYR 96  ? CE1 ? A TYR 96  CE1 
73  1 Y 1 N TYR 96  ? CE2 ? A TYR 96  CE2 
74  1 Y 1 N TYR 96  ? CZ  ? A TYR 96  CZ  
75  1 Y 1 N TYR 96  ? OH  ? A TYR 96  OH  
76  1 Y 1 N CYS 97  ? SG  ? A CYS 97  SG  
77  1 Y 1 N THR 103 ? OG1 ? A THR 103 OG1 
78  1 Y 1 N THR 103 ? CG2 ? A THR 103 CG2 
79  1 Y 1 N GLU 107 ? CG  ? A GLU 107 CG  
80  1 Y 1 N GLU 107 ? CD  ? A GLU 107 CD  
81  1 Y 1 N GLU 107 ? OE1 ? A GLU 107 OE1 
82  1 Y 1 N GLU 107 ? OE2 ? A GLU 107 OE2 
83  1 Y 1 N GLU 108 ? CG  ? A GLU 108 CG  
84  1 Y 1 N GLU 108 ? CD  ? A GLU 108 CD  
85  1 Y 1 N GLU 108 ? OE1 ? A GLU 108 OE1 
86  1 Y 1 N GLU 108 ? OE2 ? A GLU 108 OE2 
87  1 Y 1 N ASP 111 ? CG  ? A ASP 111 CG  
88  1 Y 1 N ASP 111 ? OD1 ? A ASP 111 OD1 
89  1 Y 1 N ASP 111 ? OD2 ? A ASP 111 OD2 
90  1 Y 1 R MET 65  ? CG  ? B MET 85  CG  
91  1 Y 1 R MET 65  ? SD  ? B MET 85  SD  
92  1 Y 1 R MET 65  ? CE  ? B MET 85  CE  
93  1 Y 1 R VAL 66  ? CG1 ? B VAL 86  CG1 
94  1 Y 1 R VAL 66  ? CG2 ? B VAL 86  CG2 
95  1 Y 1 R VAL 80  ? CG1 ? B VAL 100 CG1 
96  1 Y 1 R VAL 80  ? CG2 ? B VAL 100 CG2 
97  1 Y 1 R PHE 87  ? CG  ? B PHE 107 CG  
98  1 Y 1 R PHE 87  ? CD1 ? B PHE 107 CD1 
99  1 Y 1 R PHE 87  ? CD2 ? B PHE 107 CD2 
100 1 Y 1 R PHE 87  ? CE1 ? B PHE 107 CE1 
101 1 Y 1 R PHE 87  ? CE2 ? B PHE 107 CE2 
102 1 Y 1 R PHE 87  ? CZ  ? B PHE 107 CZ  
103 1 Y 1 R LEU 88  ? CG  ? B LEU 108 CG  
104 1 Y 1 R LEU 88  ? CD1 ? B LEU 108 CD1 
105 1 Y 1 R LEU 88  ? CD2 ? B LEU 108 CD2 
106 1 Y 1 R ARG 95  ? CG  ? B ARG 115 CG  
107 1 Y 1 R ARG 95  ? CD  ? B ARG 115 CD  
108 1 Y 1 R ARG 95  ? NE  ? B ARG 115 NE  
109 1 Y 1 R ARG 95  ? CZ  ? B ARG 115 CZ  
110 1 Y 1 R ARG 95  ? NH1 ? B ARG 115 NH1 
111 1 Y 1 R ARG 95  ? NH2 ? B ARG 115 NH2 
112 1 Y 1 R TYR 96  ? CG  ? B TYR 116 CG  
113 1 Y 1 R TYR 96  ? CD1 ? B TYR 116 CD1 
114 1 Y 1 R TYR 96  ? CD2 ? B TYR 116 CD2 
115 1 Y 1 R TYR 96  ? CE1 ? B TYR 116 CE1 
116 1 Y 1 R TYR 96  ? CE2 ? B TYR 116 CE2 
117 1 Y 1 R TYR 96  ? CZ  ? B TYR 116 CZ  
118 1 Y 1 R TYR 96  ? OH  ? B TYR 116 OH  
119 1 Y 1 R THR 97  ? OG1 ? B THR 117 OG1 
120 1 Y 1 R THR 97  ? CG2 ? B THR 117 CG2 
121 1 Y 1 R LYS 98  ? CG  ? B LYS 118 CG  
122 1 Y 1 R LYS 98  ? CD  ? B LYS 118 CD  
123 1 Y 1 R LYS 98  ? CE  ? B LYS 118 CE  
124 1 Y 1 R LYS 98  ? NZ  ? B LYS 118 NZ  
125 1 Y 1 R LYS 100 ? CG  ? B LYS 120 CG  
126 1 Y 1 R LYS 100 ? CD  ? B LYS 120 CD  
127 1 Y 1 R LYS 100 ? CE  ? B LYS 120 CE  
128 1 Y 1 R LYS 100 ? NZ  ? B LYS 120 NZ  
129 1 Y 1 R VAL 173 ? CG1 ? B VAL 193 CG1 
130 1 Y 1 R VAL 173 ? CG2 ? B VAL 193 CG2 
131 1 Y 1 R LYS 174 ? CG  ? B LYS 194 CG  
132 1 Y 1 R LYS 174 ? CD  ? B LYS 194 CD  
133 1 Y 1 R LYS 174 ? CE  ? B LYS 194 CE  
134 1 Y 1 R LYS 174 ? NZ  ? B LYS 194 NZ  
135 1 Y 1 R LEU 176 ? CG  ? B LEU 196 CG  
136 1 Y 1 R LEU 176 ? CD1 ? B LEU 196 CD1 
137 1 Y 1 R LEU 176 ? CD2 ? B LEU 196 CD2 
138 1 Y 1 R ASP 177 ? CG  ? B ASP 197 CG  
139 1 Y 1 R ASP 177 ? OD1 ? B ASP 197 OD1 
140 1 Y 1 R ASP 177 ? OD2 ? B ASP 197 OD2 
141 1 Y 1 R ARG 182 ? CG  ? B ARG 202 CG  
142 1 Y 1 R ARG 182 ? CD  ? B ARG 202 CD  
143 1 Y 1 R ARG 182 ? NE  ? B ARG 202 NE  
144 1 Y 1 R ARG 182 ? CZ  ? B ARG 202 CZ  
145 1 Y 1 R ARG 182 ? NH1 ? B ARG 202 NH1 
146 1 Y 1 R ARG 182 ? NH2 ? B ARG 202 NH2 
147 1 Y 1 R LYS 185 ? CG  ? B LYS 205 CG  
148 1 Y 1 R LYS 185 ? CD  ? B LYS 205 CD  
149 1 Y 1 R LYS 185 ? CE  ? B LYS 205 CE  
150 1 Y 1 R LYS 185 ? NZ  ? B LYS 205 NZ  
151 1 Y 1 R MET 203 ? CG  ? B MET 223 CG  
152 1 Y 1 R MET 203 ? SD  ? B MET 223 SD  
153 1 Y 1 R MET 203 ? CE  ? B MET 223 CE  
154 1 Y 1 R LYS 209 ? CG  ? B LYS 229 CG  
155 1 Y 1 R LYS 209 ? CD  ? B LYS 229 CD  
156 1 Y 1 R LYS 209 ? CE  ? B LYS 229 CE  
157 1 Y 1 R LYS 209 ? NZ  ? B LYS 229 NZ  
158 1 Y 1 R TYR 210 ? CG  ? B TYR 230 CG  
159 1 Y 1 R TYR 210 ? CD1 ? B TYR 230 CD1 
160 1 Y 1 R TYR 210 ? CD2 ? B TYR 230 CD2 
161 1 Y 1 R TYR 210 ? CE1 ? B TYR 230 CE1 
162 1 Y 1 R TYR 210 ? CE2 ? B TYR 230 CE2 
163 1 Y 1 R TYR 210 ? CZ  ? B TYR 230 CZ  
164 1 Y 1 R TYR 210 ? OH  ? B TYR 230 OH  
165 1 Y 1 R ARG 211 ? CG  ? B ARG 231 CG  
166 1 Y 1 R ARG 211 ? CD  ? B ARG 231 CD  
167 1 Y 1 R ARG 211 ? NE  ? B ARG 231 NE  
168 1 Y 1 R ARG 211 ? CZ  ? B ARG 231 CZ  
169 1 Y 1 R ARG 211 ? NH1 ? B ARG 231 NH1 
170 1 Y 1 R ARG 211 ? NH2 ? B ARG 231 NH2 
171 1 Y 1 R GLN 212 ? CG  ? B GLN 232 CG  
172 1 Y 1 R GLN 212 ? CD  ? B GLN 232 CD  
173 1 Y 1 R GLN 212 ? OE1 ? B GLN 232 OE1 
174 1 Y 1 R GLN 212 ? NE2 ? B GLN 232 NE2 
175 1 Y 1 R SER 214 ? OG  ? B SER 234 OG  
176 1 Y 1 R ASP 216 ? CG  ? B ASP 236 CG  
177 1 Y 1 R ASP 216 ? OD1 ? B ASP 236 OD1 
178 1 Y 1 R ASP 216 ? OD2 ? B ASP 236 OD2 
179 1 Y 1 R THR 220 ? OG1 ? B THR 240 OG1 
180 1 Y 1 R THR 220 ? CG2 ? B THR 240 CG2 
181 1 Y 1 R SER 222 ? OG  ? B SER 242 OG  
182 1 Y 1 R MET 243 ? CG  ? B MET 263 CG  
183 1 Y 1 R MET 243 ? SD  ? B MET 263 SD  
184 1 Y 1 R MET 243 ? CE  ? B MET 263 CE  
185 1 Y 1 R LEU 257 ? CG  ? B LEU 277 CG  
186 1 Y 1 R LEU 257 ? CD1 ? B LEU 277 CD1 
187 1 Y 1 R LEU 257 ? CD2 ? B LEU 277 CD2 
188 1 Y 1 R ARG 258 ? CG  ? B ARG 278 CG  
189 1 Y 1 R ARG 258 ? CD  ? B ARG 278 CD  
190 1 Y 1 R ARG 258 ? NE  ? B ARG 278 NE  
191 1 Y 1 R ARG 258 ? CZ  ? B ARG 278 CZ  
192 1 Y 1 R ARG 258 ? NH1 ? B ARG 278 NH1 
193 1 Y 1 R ARG 258 ? NH2 ? B ARG 278 NH2 
194 1 Y 1 R SER 261 ? OG  ? B SER 281 OG  
195 1 Y 1 R VAL 262 ? CG1 ? B VAL 282 CG1 
196 1 Y 1 R VAL 262 ? CG2 ? B VAL 282 CG2 
197 1 Y 1 R SER 266 ? OG  ? B SER 286 OG  
198 1 Y 1 R SER 268 ? OG  ? B SER 288 OG  
199 1 Y 1 R GLU 270 ? CG  ? B GLU 290 CG  
200 1 Y 1 R GLU 270 ? CD  ? B GLU 290 CD  
201 1 Y 1 R GLU 270 ? OE1 ? B GLU 290 OE1 
202 1 Y 1 R GLU 270 ? OE2 ? B GLU 290 OE2 
203 1 Y 1 R ARG 273 ? CG  ? B ARG 293 CG  
204 1 Y 1 R ARG 273 ? CD  ? B ARG 293 CD  
205 1 Y 1 R ARG 273 ? NE  ? B ARG 293 NE  
206 1 Y 1 R ARG 273 ? CZ  ? B ARG 293 CZ  
207 1 Y 1 R ARG 273 ? NH1 ? B ARG 293 NH1 
208 1 Y 1 R ARG 273 ? NH2 ? B ARG 293 NH2 
209 1 Y 1 R ASN 274 ? CG  ? B ASN 294 CG  
210 1 Y 1 R ASN 274 ? OD1 ? B ASN 294 OD1 
211 1 Y 1 R ASN 274 ? ND2 ? B ASN 294 ND2 
212 1 Y 1 R ARG 277 ? CG  ? B ARG 297 CG  
213 1 Y 1 R ARG 277 ? CD  ? B ARG 297 CD  
214 1 Y 1 R ARG 277 ? NE  ? B ARG 297 NE  
215 1 Y 1 R ARG 277 ? CZ  ? B ARG 297 CZ  
216 1 Y 1 R ARG 277 ? NH1 ? B ARG 297 NH1 
217 1 Y 1 R ARG 277 ? NH2 ? B ARG 297 NH2 
218 1 Y 1 R ILE 306 ? CG1 ? B ILE 326 CG1 
219 1 Y 1 R ILE 306 ? CG2 ? B ILE 326 CG2 
220 1 Y 1 R ILE 306 ? CD1 ? B ILE 326 CD1 
221 1 Y 1 R THR 307 ? OG1 ? B THR 327 OG1 
222 1 Y 1 R THR 307 ? CG2 ? B THR 327 CG2 
223 1 Y 1 R ILE 308 ? CG1 ? B ILE 328 CG1 
224 1 Y 1 R ILE 308 ? CG2 ? B ILE 328 CG2 
225 1 Y 1 R ILE 308 ? CD1 ? B ILE 328 CD1 
226 1 Y 1 R GLU 310 ? CG  ? B GLU 330 CG  
227 1 Y 1 R GLU 310 ? CD  ? B GLU 330 CD  
228 1 Y 1 R GLU 310 ? OE1 ? B GLU 330 OE1 
229 1 Y 1 R GLU 310 ? OE2 ? B GLU 330 OE2 
230 1 Y 1 R THR 311 ? OG1 ? B THR 331 OG1 
231 1 Y 1 R THR 311 ? CG2 ? B THR 331 CG2 
232 1 Y 1 R THR 312 ? OG1 ? B THR 332 OG1 
233 1 Y 1 R THR 312 ? CG2 ? B THR 332 CG2 
234 1 Y 1 R PHE 313 ? CG  ? B PHE 333 CG  
235 1 Y 1 R PHE 313 ? CD1 ? B PHE 333 CD1 
236 1 Y 1 R PHE 313 ? CD2 ? B PHE 333 CD2 
237 1 Y 1 R PHE 313 ? CE1 ? B PHE 333 CE1 
238 1 Y 1 R PHE 313 ? CE2 ? B PHE 333 CE2 
239 1 Y 1 R PHE 313 ? CZ  ? B PHE 333 CZ  
240 1 Y 1 R THR 315 ? OG1 ? B THR 335 OG1 
241 1 Y 1 R THR 315 ? CG2 ? B THR 335 CG2 
242 1 Y 1 R GLU 341 ? CG  ? B GLU 361 CG  
243 1 Y 1 R GLU 341 ? CD  ? B GLU 361 CD  
244 1 Y 1 R GLU 341 ? OE1 ? B GLU 361 OE1 
245 1 Y 1 R GLU 341 ? OE2 ? B GLU 361 OE2 
246 1 Y 1 R LYS 344 ? CG  ? B LYS 364 CG  
247 1 Y 1 R LYS 344 ? CD  ? B LYS 364 CD  
248 1 Y 1 R LYS 344 ? CE  ? B LYS 364 CE  
249 1 Y 1 R LYS 344 ? NZ  ? B LYS 364 NZ  
250 1 Y 1 R ARG 345 ? CG  ? B ARG 365 CG  
251 1 Y 1 R ARG 345 ? CD  ? B ARG 365 CD  
252 1 Y 1 R ARG 345 ? NE  ? B ARG 365 NE  
253 1 Y 1 R ARG 345 ? CZ  ? B ARG 365 CZ  
254 1 Y 1 R ARG 345 ? NH1 ? B ARG 365 NH1 
255 1 Y 1 R ARG 345 ? NH2 ? B ARG 365 NH2 
256 1 Y 1 R ARG 348 ? CG  ? B ARG 368 CG  
257 1 Y 1 R ARG 348 ? CD  ? B ARG 368 CD  
258 1 Y 1 R ARG 348 ? NE  ? B ARG 368 NE  
259 1 Y 1 R ARG 348 ? CZ  ? B ARG 368 CZ  
260 1 Y 1 R ARG 348 ? NH1 ? B ARG 368 NH1 
261 1 Y 1 R ARG 348 ? NH2 ? B ARG 368 NH2 
262 1 Y 1 R GLU 349 ? CG  ? B GLU 369 CG  
263 1 Y 1 R GLU 349 ? CD  ? B GLU 369 CD  
264 1 Y 1 R GLU 349 ? OE1 ? B GLU 369 OE1 
265 1 Y 1 R GLU 349 ? OE2 ? B GLU 369 OE2 
266 1 Y 1 R PHE 350 ? CG  ? B PHE 370 CG  
267 1 Y 1 R PHE 350 ? CD1 ? B PHE 370 CD1 
268 1 Y 1 R PHE 350 ? CD2 ? B PHE 370 CD2 
269 1 Y 1 R PHE 350 ? CE1 ? B PHE 370 CE1 
270 1 Y 1 R PHE 350 ? CE2 ? B PHE 370 CE2 
271 1 Y 1 R PHE 350 ? CZ  ? B PHE 370 CZ  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BJK 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BJK 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BJK 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9BJK 
_struct.title                        'Inactive mu opioid receptor bound to Nb6, naloxone and NAM' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BJK 
_struct_keywords.text            'G-protein coupled receptor, inactive, opioid, allosteric modulator, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9BJK       9BJK   ? 1 ? 1 
2 UNP OPRM_MOUSE P42866 ? 2 
;GPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFG
NFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDR
YIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPV
LIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALG
YTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
;
6 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BJK N 1  ? 133 ? 9BJK   1 ? 133 ? 1 133 
2 2 9BJK R 26 ? 418 ? P42866 6 ? 398 ? 6 398 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 9BJK MET R 1   ? UNP P42866 ?   ?   'initiating methionine' -19 1  
2 9BJK LYS R 2   ? UNP P42866 ?   ?   'expression tag'        -18 2  
2 9BJK THR R 3   ? UNP P42866 ?   ?   'expression tag'        -17 3  
2 9BJK ILE R 4   ? UNP P42866 ?   ?   'expression tag'        -16 4  
2 9BJK ILE R 5   ? UNP P42866 ?   ?   'expression tag'        -15 5  
2 9BJK ALA R 6   ? UNP P42866 ?   ?   'expression tag'        -14 6  
2 9BJK LEU R 7   ? UNP P42866 ?   ?   'expression tag'        -13 7  
2 9BJK SER R 8   ? UNP P42866 ?   ?   'expression tag'        -12 8  
2 9BJK TYR R 9   ? UNP P42866 ?   ?   'expression tag'        -11 9  
2 9BJK ILE R 10  ? UNP P42866 ?   ?   'expression tag'        -10 10 
2 9BJK PHE R 11  ? UNP P42866 ?   ?   'expression tag'        -9  11 
2 9BJK CYS R 12  ? UNP P42866 ?   ?   'expression tag'        -8  12 
2 9BJK LEU R 13  ? UNP P42866 ?   ?   'expression tag'        -7  13 
2 9BJK VAL R 14  ? UNP P42866 ?   ?   'expression tag'        -6  14 
2 9BJK PHE R 15  ? UNP P42866 ?   ?   'expression tag'        -5  15 
2 9BJK ALA R 16  ? UNP P42866 ?   ?   'expression tag'        -4  16 
2 9BJK ASP R 17  ? UNP P42866 ?   ?   'expression tag'        -3  17 
2 9BJK TYR R 18  ? UNP P42866 ?   ?   'expression tag'        -2  18 
2 9BJK LYS R 19  ? UNP P42866 ?   ?   'expression tag'        -1  19 
2 9BJK ASP R 20  ? UNP P42866 ?   ?   'expression tag'        0   20 
2 9BJK ASP R 21  ? UNP P42866 ?   ?   'expression tag'        1   21 
2 9BJK ASP R 22  ? UNP P42866 ?   ?   'expression tag'        2   22 
2 9BJK ASP R 23  ? UNP P42866 ?   ?   'expression tag'        3   23 
2 9BJK ALA R 24  ? UNP P42866 ?   ?   'expression tag'        4   24 
2 9BJK MET R 25  ? UNP P42866 ?   ?   'expression tag'        5   25 
2 9BJK LEU R 284 ? UNP P42866 MET 264 'engineered mutation'   264 26 
2 9BJK ARG R 289 ? UNP P42866 LYS 269 'engineered mutation'   269 27 
2 9BJK ASP R 419 ? UNP P42866 ?   ?   'expression tag'        399 28 
2 9BJK ILE R 420 ? UNP P42866 ?   ?   'expression tag'        400 29 
2 9BJK HIS R 421 ? UNP P42866 ?   ?   'expression tag'        401 30 
2 9BJK HIS R 422 ? UNP P42866 ?   ?   'expression tag'        402 31 
2 9BJK HIS R 423 ? UNP P42866 ?   ?   'expression tag'        403 32 
2 9BJK HIS R 424 ? UNP P42866 ?   ?   'expression tag'        404 33 
2 9BJK HIS R 425 ? UNP P42866 ?   ?   'expression tag'        405 34 
2 9BJK HIS R 426 ? UNP P42866 ?   ?   'expression tag'        406 35 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL B 86  ? TYR B 116 ? VAL R 66  TYR R 96  1 ? 31 
HELX_P HELX_P2  AA2 ASN B 124 ? SER B 139 ? ASN R 104 SER R 119 1 ? 16 
HELX_P HELX_P3  AA3 THR B 140 ? GLY B 151 ? THR R 120 GLY R 131 1 ? 12 
HELX_P HELX_P4  AA4 ASN B 157 ? HIS B 191 ? ASN R 137 HIS R 171 1 ? 35 
HELX_P HELX_P5  AA5 HIS B 191 ? PHE B 198 ? HIS R 171 PHE R 178 1 ? 8  
HELX_P HELX_P6  AA6 THR B 200 ? MET B 225 ? THR R 180 MET R 205 1 ? 26 
HELX_P HELX_P7  AA7 TRP B 246 ? MET B 263 ? TRP R 226 MET R 243 1 ? 18 
HELX_P HELX_P8  AA8 MET B 263 ? VAL B 282 ? MET R 243 VAL R 262 1 ? 20 
HELX_P HELX_P9  AA9 SER B 288 ? ILE B 326 ? SER R 268 ILE R 306 1 ? 39 
HELX_P HELX_P10 AB1 THR B 331 ? ASP B 360 ? THR R 311 ASP R 340 1 ? 30 
HELX_P HELX_P11 AB2 ASP B 360 ? PHE B 370 ? ASP R 340 PHE R 350 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           B 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            160 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            237 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            R 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             140 
_struct_conn.ptnr2_auth_asym_id            R 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             217 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.025 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 32  ? GLY A 37  ? ARG N 32  GLY N 37  
AA1 2 ASN A 98  ? ARG A 102 ? ASN N 98  ARG N 102 
AA1 3 LEU A 110 ? TRP A 113 ? LEU N 110 TRP N 113 
AA2 1 ALA B 226 ? THR B 228 ? ALA R 206 THR R 208 
AA2 2 CYS B 237 ? LEU B 239 ? CYS R 217 LEU R 219 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 37  ? N GLY N 37  O ASN A 98  ? O ASN N 98  
AA1 2 3 N TYR A 101 ? N TYR N 101 O LEU A 110 ? O LEU N 110 
AA2 1 2 N THR B 227 ? N THR R 207 O THR B 238 ? O THR R 218 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG N 32  ? ? -172.71 139.53  
2 1 ALA N 51  ? ? -171.64 130.52  
3 1 THR N 54  ? ? -75.89  -166.31 
4 1 ARG R 179 ? ? -143.48 23.31   
5 1 SER R 222 ? ? -66.05  -73.85  
6 1 PHE R 241 ? ? -108.36 -60.37  
7 1 THR R 307 ? ? 61.52   60.39   
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ALA 
_pdbx_validate_peptide_omega.auth_asym_id_1   R 
_pdbx_validate_peptide_omega.auth_seq_id_1    240 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   PHE 
_pdbx_validate_peptide_omega.auth_asym_id_2   R 
_pdbx_validate_peptide_omega.auth_seq_id_2    241 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            144.97 
# 
_pdbx_entry_details.entry_id                   9BJK 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   ? 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9BJK 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9BJK 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.26 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               128613 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 
'mu-type opioid receptor with kappa-type opioid receptor ICL3 in complex with Nb6, naloxone and a negative allosteric modulator' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2' 
# 
_em_imaging.entry_id                        9BJK 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             600 
_em_imaging.nominal_defocus_max             1400 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9BJK 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9BJK 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 N MET 1   ? A MET 1   
2   1 Y 1 N ALA 2   ? A ALA 2   
3   1 Y 1 N GLN 3   ? A GLN 3   
4   1 Y 1 N VAL 4   ? A VAL 4   
5   1 Y 1 N GLN 5   ? A GLN 5   
6   1 Y 1 N LEU 6   ? A LEU 6   
7   1 Y 1 N GLN 7   ? A GLN 7   
8   1 Y 1 N GLU 8   ? A GLU 8   
9   1 Y 1 N SER 9   ? A SER 9   
10  1 Y 1 N GLY 10  ? A GLY 10  
11  1 Y 1 N GLY 11  ? A GLY 11  
12  1 Y 1 N GLY 12  ? A GLY 12  
13  1 Y 1 N LEU 13  ? A LEU 13  
14  1 Y 1 N VAL 14  ? A VAL 14  
15  1 Y 1 N GLN 15  ? A GLN 15  
16  1 Y 1 N ALA 16  ? A ALA 16  
17  1 Y 1 N GLY 17  ? A GLY 17  
18  1 Y 1 N GLU 18  ? A GLU 18  
19  1 Y 1 N SER 19  ? A SER 19  
20  1 Y 1 N LEU 20  ? A LEU 20  
21  1 Y 1 N ARG 21  ? A ARG 21  
22  1 Y 1 N LEU 22  ? A LEU 22  
23  1 Y 1 N SER 23  ? A SER 23  
24  1 Y 1 N CYS 24  ? A CYS 24  
25  1 Y 1 N ALA 25  ? A ALA 25  
26  1 Y 1 N ALA 26  ? A ALA 26  
27  1 Y 1 N SER 27  ? A SER 27  
28  1 Y 1 N GLY 28  ? A GLY 28  
29  1 Y 1 N ARG 41  ? A ARG 41  
30  1 Y 1 N VAL 42  ? A VAL 42  
31  1 Y 1 N SER 43  ? A SER 43  
32  1 Y 1 N GLY 44  ? A GLY 44  
33  1 Y 1 N ASN 45  ? A ASN 45  
34  1 Y 1 N GLN 46  ? A GLN 46  
35  1 Y 1 N ARG 47  ? A ARG 47  
36  1 Y 1 N GLU 48  ? A GLU 48  
37  1 Y 1 N TYR 61  ? A TYR 61  
38  1 Y 1 N GLY 62  ? A GLY 62  
39  1 Y 1 N ASP 63  ? A ASP 63  
40  1 Y 1 N SER 64  ? A SER 64  
41  1 Y 1 N VAL 65  ? A VAL 65  
42  1 Y 1 N LYS 66  ? A LYS 66  
43  1 Y 1 N GLY 67  ? A GLY 67  
44  1 Y 1 N ARG 68  ? A ARG 68  
45  1 Y 1 N PHE 69  ? A PHE 69  
46  1 Y 1 N ALA 76  ? A ALA 76  
47  1 Y 1 N LYS 77  ? A LYS 77  
48  1 Y 1 N ASN 78  ? A ASN 78  
49  1 Y 1 N THR 79  ? A THR 79  
50  1 Y 1 N VAL 80  ? A VAL 80  
51  1 Y 1 N TYR 81  ? A TYR 81  
52  1 Y 1 N LEU 82  ? A LEU 82  
53  1 Y 1 N GLN 83  ? A GLN 83  
54  1 Y 1 N MET 84  ? A MET 84  
55  1 Y 1 N SER 85  ? A SER 85  
56  1 Y 1 N SER 86  ? A SER 86  
57  1 Y 1 N LEU 87  ? A LEU 87  
58  1 Y 1 N LYS 88  ? A LYS 88  
59  1 Y 1 N PRO 89  ? A PRO 89  
60  1 Y 1 N GLU 90  ? A GLU 90  
61  1 Y 1 N ASP 91  ? A ASP 91  
62  1 Y 1 N THR 92  ? A THR 92  
63  1 Y 1 N GLN 115 ? A GLN 115 
64  1 Y 1 N GLY 116 ? A GLY 116 
65  1 Y 1 N THR 117 ? A THR 117 
66  1 Y 1 N GLN 118 ? A GLN 118 
67  1 Y 1 N VAL 119 ? A VAL 119 
68  1 Y 1 N THR 120 ? A THR 120 
69  1 Y 1 N VAL 121 ? A VAL 121 
70  1 Y 1 N SER 122 ? A SER 122 
71  1 Y 1 N SER 123 ? A SER 123 
72  1 Y 1 N HIS 124 ? A HIS 124 
73  1 Y 1 N HIS 125 ? A HIS 125 
74  1 Y 1 N HIS 126 ? A HIS 126 
75  1 Y 1 N HIS 127 ? A HIS 127 
76  1 Y 1 N HIS 128 ? A HIS 128 
77  1 Y 1 N HIS 129 ? A HIS 129 
78  1 Y 1 N GLU 130 ? A GLU 130 
79  1 Y 1 N PRO 131 ? A PRO 131 
80  1 Y 1 N GLU 132 ? A GLU 132 
81  1 Y 1 N ALA 133 ? A ALA 133 
82  1 Y 1 R MET -19 ? B MET 1   
83  1 Y 1 R LYS -18 ? B LYS 2   
84  1 Y 1 R THR -17 ? B THR 3   
85  1 Y 1 R ILE -16 ? B ILE 4   
86  1 Y 1 R ILE -15 ? B ILE 5   
87  1 Y 1 R ALA -14 ? B ALA 6   
88  1 Y 1 R LEU -13 ? B LEU 7   
89  1 Y 1 R SER -12 ? B SER 8   
90  1 Y 1 R TYR -11 ? B TYR 9   
91  1 Y 1 R ILE -10 ? B ILE 10  
92  1 Y 1 R PHE -9  ? B PHE 11  
93  1 Y 1 R CYS -8  ? B CYS 12  
94  1 Y 1 R LEU -7  ? B LEU 13  
95  1 Y 1 R VAL -6  ? B VAL 14  
96  1 Y 1 R PHE -5  ? B PHE 15  
97  1 Y 1 R ALA -4  ? B ALA 16  
98  1 Y 1 R ASP -3  ? B ASP 17  
99  1 Y 1 R TYR -2  ? B TYR 18  
100 1 Y 1 R LYS -1  ? B LYS 19  
101 1 Y 1 R ASP 0   ? B ASP 20  
102 1 Y 1 R ASP 1   ? B ASP 21  
103 1 Y 1 R ASP 2   ? B ASP 22  
104 1 Y 1 R ASP 3   ? B ASP 23  
105 1 Y 1 R ALA 4   ? B ALA 24  
106 1 Y 1 R MET 5   ? B MET 25  
107 1 Y 1 R GLY 6   ? B GLY 26  
108 1 Y 1 R PRO 7   ? B PRO 27  
109 1 Y 1 R GLY 8   ? B GLY 28  
110 1 Y 1 R ASN 9   ? B ASN 29  
111 1 Y 1 R ILE 10  ? B ILE 30  
112 1 Y 1 R SER 11  ? B SER 31  
113 1 Y 1 R ASP 12  ? B ASP 32  
114 1 Y 1 R CYS 13  ? B CYS 33  
115 1 Y 1 R SER 14  ? B SER 34  
116 1 Y 1 R ASP 15  ? B ASP 35  
117 1 Y 1 R PRO 16  ? B PRO 36  
118 1 Y 1 R LEU 17  ? B LEU 37  
119 1 Y 1 R ALA 18  ? B ALA 38  
120 1 Y 1 R PRO 19  ? B PRO 39  
121 1 Y 1 R ALA 20  ? B ALA 40  
122 1 Y 1 R SER 21  ? B SER 41  
123 1 Y 1 R CYS 22  ? B CYS 42  
124 1 Y 1 R SER 23  ? B SER 43  
125 1 Y 1 R PRO 24  ? B PRO 44  
126 1 Y 1 R ALA 25  ? B ALA 45  
127 1 Y 1 R PRO 26  ? B PRO 46  
128 1 Y 1 R GLY 27  ? B GLY 47  
129 1 Y 1 R SER 28  ? B SER 48  
130 1 Y 1 R TRP 29  ? B TRP 49  
131 1 Y 1 R LEU 30  ? B LEU 50  
132 1 Y 1 R ASN 31  ? B ASN 51  
133 1 Y 1 R LEU 32  ? B LEU 52  
134 1 Y 1 R SER 33  ? B SER 53  
135 1 Y 1 R HIS 34  ? B HIS 54  
136 1 Y 1 R VAL 35  ? B VAL 55  
137 1 Y 1 R ASP 36  ? B ASP 56  
138 1 Y 1 R GLY 37  ? B GLY 57  
139 1 Y 1 R ASN 38  ? B ASN 58  
140 1 Y 1 R GLN 39  ? B GLN 59  
141 1 Y 1 R SER 40  ? B SER 60  
142 1 Y 1 R ASP 41  ? B ASP 61  
143 1 Y 1 R PRO 42  ? B PRO 62  
144 1 Y 1 R CYS 43  ? B CYS 63  
145 1 Y 1 R GLY 44  ? B GLY 64  
146 1 Y 1 R PRO 45  ? B PRO 65  
147 1 Y 1 R ASN 46  ? B ASN 66  
148 1 Y 1 R ARG 47  ? B ARG 67  
149 1 Y 1 R THR 48  ? B THR 68  
150 1 Y 1 R GLY 49  ? B GLY 69  
151 1 Y 1 R LEU 50  ? B LEU 70  
152 1 Y 1 R GLY 51  ? B GLY 71  
153 1 Y 1 R GLY 52  ? B GLY 72  
154 1 Y 1 R SER 53  ? B SER 73  
155 1 Y 1 R HIS 54  ? B HIS 74  
156 1 Y 1 R SER 55  ? B SER 75  
157 1 Y 1 R LEU 56  ? B LEU 76  
158 1 Y 1 R CYS 57  ? B CYS 77  
159 1 Y 1 R PRO 58  ? B PRO 78  
160 1 Y 1 R GLN 59  ? B GLN 79  
161 1 Y 1 R THR 60  ? B THR 80  
162 1 Y 1 R GLY 61  ? B GLY 81  
163 1 Y 1 R SER 62  ? B SER 82  
164 1 Y 1 R PRO 63  ? B PRO 83  
165 1 Y 1 R SER 64  ? B SER 84  
166 1 Y 1 R CYS 351 ? B CYS 371 
167 1 Y 1 R ILE 352 ? B ILE 372 
168 1 Y 1 R PRO 353 ? B PRO 373 
169 1 Y 1 R THR 354 ? B THR 374 
170 1 Y 1 R SER 355 ? B SER 375 
171 1 Y 1 R SER 356 ? B SER 376 
172 1 Y 1 R THR 357 ? B THR 377 
173 1 Y 1 R ILE 358 ? B ILE 378 
174 1 Y 1 R GLU 359 ? B GLU 379 
175 1 Y 1 R GLN 360 ? B GLN 380 
176 1 Y 1 R GLN 361 ? B GLN 381 
177 1 Y 1 R ASN 362 ? B ASN 382 
178 1 Y 1 R SER 363 ? B SER 383 
179 1 Y 1 R ALA 364 ? B ALA 384 
180 1 Y 1 R ARG 365 ? B ARG 385 
181 1 Y 1 R ILE 366 ? B ILE 386 
182 1 Y 1 R ARG 367 ? B ARG 387 
183 1 Y 1 R GLN 368 ? B GLN 388 
184 1 Y 1 R ASN 369 ? B ASN 389 
185 1 Y 1 R THR 370 ? B THR 390 
186 1 Y 1 R ARG 371 ? B ARG 391 
187 1 Y 1 R GLU 372 ? B GLU 392 
188 1 Y 1 R HIS 373 ? B HIS 393 
189 1 Y 1 R PRO 374 ? B PRO 394 
190 1 Y 1 R SER 375 ? B SER 395 
191 1 Y 1 R THR 376 ? B THR 396 
192 1 Y 1 R ALA 377 ? B ALA 397 
193 1 Y 1 R ASN 378 ? B ASN 398 
194 1 Y 1 R THR 379 ? B THR 399 
195 1 Y 1 R VAL 380 ? B VAL 400 
196 1 Y 1 R ASP 381 ? B ASP 401 
197 1 Y 1 R ARG 382 ? B ARG 402 
198 1 Y 1 R THR 383 ? B THR 403 
199 1 Y 1 R ASN 384 ? B ASN 404 
200 1 Y 1 R HIS 385 ? B HIS 405 
201 1 Y 1 R GLN 386 ? B GLN 406 
202 1 Y 1 R LEU 387 ? B LEU 407 
203 1 Y 1 R GLU 388 ? B GLU 408 
204 1 Y 1 R ASN 389 ? B ASN 409 
205 1 Y 1 R LEU 390 ? B LEU 410 
206 1 Y 1 R GLU 391 ? B GLU 411 
207 1 Y 1 R ALA 392 ? B ALA 412 
208 1 Y 1 R GLU 393 ? B GLU 413 
209 1 Y 1 R THR 394 ? B THR 414 
210 1 Y 1 R ALA 395 ? B ALA 415 
211 1 Y 1 R PRO 396 ? B PRO 416 
212 1 Y 1 R LEU 397 ? B LEU 417 
213 1 Y 1 R PRO 398 ? B PRO 418 
214 1 Y 1 R ASP 399 ? B ASP 419 
215 1 Y 1 R ILE 400 ? B ILE 420 
216 1 Y 1 R HIS 401 ? B HIS 421 
217 1 Y 1 R HIS 402 ? B HIS 422 
218 1 Y 1 R HIS 403 ? B HIS 423 
219 1 Y 1 R HIS 404 ? B HIS 424 
220 1 Y 1 R HIS 405 ? B HIS 425 
221 1 Y 1 R HIS 406 ? B HIS 426 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1APU C14  C Y N 1   
A1APU C13  C Y N 2   
A1APU C12  C Y N 3   
A1APU C11  C Y N 4   
A1APU C10  C Y N 5   
A1APU C15  C Y N 6   
A1APU C17  C N N 7   
A1APU C01  C N N 8   
A1APU N02  N N N 9   
A1APU C03  C N N 10  
A1APU C04  C N S 11  
A1APU N05  N N N 12  
A1APU C06  C N N 13  
A1APU C07  C N N 14  
A1APU S08  S N N 15  
A1APU C09  C Y N 16  
A1APU O16  O N N 17  
A1APU C18  C Y N 18  
A1APU C19  C Y N 19  
A1APU C20  C Y N 20  
A1APU C21  C Y N 21  
A1APU C22  C Y N 22  
A1APU C23  C Y N 23  
A1APU C24  C Y N 24  
A1APU N25  N Y N 25  
A1APU C26  C Y N 26  
A1APU C27  C Y N 27  
A1APU C28  C Y N 28  
A1APU C29  C Y N 29  
A1APU C30  C Y N 30  
A1APU C31  C Y N 31  
A1APU C32  C Y N 32  
A1APU O33  O N N 33  
A1APU C34  C N N 34  
A1APU C35  C Y N 35  
A1APU C36  C Y N 36  
A1APU C37  C Y N 37  
A1APU O38  O N N 38  
A1APU C39  C N N 39  
A1APU C40  C Y N 40  
A1APU C41  C N N 41  
A1APU C42  C Y N 42  
A1APU C43  C Y N 43  
A1APU O44  O N N 44  
A1APU H1   H N N 45  
A1APU H2   H N N 46  
A1APU H3   H N N 47  
A1APU H4   H N N 48  
A1APU H5   H N N 49  
A1APU H6   H N N 50  
A1APU H7   H N N 51  
A1APU H8   H N N 52  
A1APU H9   H N N 53  
A1APU H10  H N N 54  
A1APU H11  H N N 55  
A1APU H12  H N N 56  
A1APU H13  H N N 57  
A1APU H14  H N N 58  
A1APU H15  H N N 59  
A1APU H16  H N N 60  
A1APU H17  H N N 61  
A1APU H18  H N N 62  
A1APU H19  H N N 63  
A1APU H20  H N N 64  
A1APU H21  H N N 65  
A1APU H22  H N N 66  
A1APU H23  H N N 67  
A1APU H24  H N N 68  
A1APU H25  H N N 69  
A1APU H26  H N N 70  
A1APU H27  H N N 71  
A1APU H28  H N N 72  
A1APU H29  H N N 73  
A1APU H30  H N N 74  
A1APU H31  H N N 75  
A1APU H32  H N N 76  
A1APU H33  H N N 77  
A1APU H34  H N N 78  
A1APU H35  H N N 79  
A1APV C01  C N N 80  
A1APV C02  C N N 81  
A1APV C03  C N N 82  
A1APV N04  N N N 83  
A1APV C05  C N N 84  
A1APV C06  C N N 85  
A1APV C07  C N S 86  
A1APV C08  C N R 87  
A1APV C09  C N N 88  
A1APV O10  O N N 89  
A1APV C11  C N N 90  
A1APV C12  C N N 91  
A1APV C13  C N S 92  
A1APV C14  C N R 93  
A1APV C15  C N N 94  
A1APV C16  C Y N 95  
A1APV C17  C Y N 96  
A1APV C18  C Y N 97  
A1APV C19  C Y N 98  
A1APV C20  C Y N 99  
A1APV C21  C Y N 100 
A1APV O22  O N N 101 
A1APV O23  O N N 102 
A1APV O24  O N N 103 
A1APV H011 H N N 104 
A1APV H012 H N N 105 
A1APV H021 H N N 106 
A1APV H032 H N N 107 
A1APV H031 H N N 108 
A1APV H051 H N N 109 
A1APV H052 H N N 110 
A1APV H061 H N N 111 
A1APV H062 H N N 112 
A1APV H081 H N N 113 
A1APV H112 H N N 114 
A1APV H111 H N N 115 
A1APV H121 H N N 116 
A1APV H122 H N N 117 
A1APV H141 H N N 118 
A1APV H152 H N N 119 
A1APV H151 H N N 120 
A1APV H201 H N N 121 
A1APV H211 H N N 122 
A1APV H221 H N N 123 
A1APV H241 H N N 124 
ALA   N    N N N 125 
ALA   CA   C N S 126 
ALA   C    C N N 127 
ALA   O    O N N 128 
ALA   CB   C N N 129 
ALA   OXT  O N N 130 
ALA   H    H N N 131 
ALA   H2   H N N 132 
ALA   HA   H N N 133 
ALA   HB1  H N N 134 
ALA   HB2  H N N 135 
ALA   HB3  H N N 136 
ALA   HXT  H N N 137 
ARG   N    N N N 138 
ARG   CA   C N S 139 
ARG   C    C N N 140 
ARG   O    O N N 141 
ARG   CB   C N N 142 
ARG   CG   C N N 143 
ARG   CD   C N N 144 
ARG   NE   N N N 145 
ARG   CZ   C N N 146 
ARG   NH1  N N N 147 
ARG   NH2  N N N 148 
ARG   OXT  O N N 149 
ARG   H    H N N 150 
ARG   H2   H N N 151 
ARG   HA   H N N 152 
ARG   HB2  H N N 153 
ARG   HB3  H N N 154 
ARG   HG2  H N N 155 
ARG   HG3  H N N 156 
ARG   HD2  H N N 157 
ARG   HD3  H N N 158 
ARG   HE   H N N 159 
ARG   HH11 H N N 160 
ARG   HH12 H N N 161 
ARG   HH21 H N N 162 
ARG   HH22 H N N 163 
ARG   HXT  H N N 164 
ASN   N    N N N 165 
ASN   CA   C N S 166 
ASN   C    C N N 167 
ASN   O    O N N 168 
ASN   CB   C N N 169 
ASN   CG   C N N 170 
ASN   OD1  O N N 171 
ASN   ND2  N N N 172 
ASN   OXT  O N N 173 
ASN   H    H N N 174 
ASN   H2   H N N 175 
ASN   HA   H N N 176 
ASN   HB2  H N N 177 
ASN   HB3  H N N 178 
ASN   HD21 H N N 179 
ASN   HD22 H N N 180 
ASN   HXT  H N N 181 
ASP   N    N N N 182 
ASP   CA   C N S 183 
ASP   C    C N N 184 
ASP   O    O N N 185 
ASP   CB   C N N 186 
ASP   CG   C N N 187 
ASP   OD1  O N N 188 
ASP   OD2  O N N 189 
ASP   OXT  O N N 190 
ASP   H    H N N 191 
ASP   H2   H N N 192 
ASP   HA   H N N 193 
ASP   HB2  H N N 194 
ASP   HB3  H N N 195 
ASP   HD2  H N N 196 
ASP   HXT  H N N 197 
CYS   N    N N N 198 
CYS   CA   C N R 199 
CYS   C    C N N 200 
CYS   O    O N N 201 
CYS   CB   C N N 202 
CYS   SG   S N N 203 
CYS   OXT  O N N 204 
CYS   H    H N N 205 
CYS   H2   H N N 206 
CYS   HA   H N N 207 
CYS   HB2  H N N 208 
CYS   HB3  H N N 209 
CYS   HG   H N N 210 
CYS   HXT  H N N 211 
GLN   N    N N N 212 
GLN   CA   C N S 213 
GLN   C    C N N 214 
GLN   O    O N N 215 
GLN   CB   C N N 216 
GLN   CG   C N N 217 
GLN   CD   C N N 218 
GLN   OE1  O N N 219 
GLN   NE2  N N N 220 
GLN   OXT  O N N 221 
GLN   H    H N N 222 
GLN   H2   H N N 223 
GLN   HA   H N N 224 
GLN   HB2  H N N 225 
GLN   HB3  H N N 226 
GLN   HG2  H N N 227 
GLN   HG3  H N N 228 
GLN   HE21 H N N 229 
GLN   HE22 H N N 230 
GLN   HXT  H N N 231 
GLU   N    N N N 232 
GLU   CA   C N S 233 
GLU   C    C N N 234 
GLU   O    O N N 235 
GLU   CB   C N N 236 
GLU   CG   C N N 237 
GLU   CD   C N N 238 
GLU   OE1  O N N 239 
GLU   OE2  O N N 240 
GLU   OXT  O N N 241 
GLU   H    H N N 242 
GLU   H2   H N N 243 
GLU   HA   H N N 244 
GLU   HB2  H N N 245 
GLU   HB3  H N N 246 
GLU   HG2  H N N 247 
GLU   HG3  H N N 248 
GLU   HE2  H N N 249 
GLU   HXT  H N N 250 
GLY   N    N N N 251 
GLY   CA   C N N 252 
GLY   C    C N N 253 
GLY   O    O N N 254 
GLY   OXT  O N N 255 
GLY   H    H N N 256 
GLY   H2   H N N 257 
GLY   HA2  H N N 258 
GLY   HA3  H N N 259 
GLY   HXT  H N N 260 
HIS   N    N N N 261 
HIS   CA   C N S 262 
HIS   C    C N N 263 
HIS   O    O N N 264 
HIS   CB   C N N 265 
HIS   CG   C Y N 266 
HIS   ND1  N Y N 267 
HIS   CD2  C Y N 268 
HIS   CE1  C Y N 269 
HIS   NE2  N Y N 270 
HIS   OXT  O N N 271 
HIS   H    H N N 272 
HIS   H2   H N N 273 
HIS   HA   H N N 274 
HIS   HB2  H N N 275 
HIS   HB3  H N N 276 
HIS   HD1  H N N 277 
HIS   HD2  H N N 278 
HIS   HE1  H N N 279 
HIS   HE2  H N N 280 
HIS   HXT  H N N 281 
ILE   N    N N N 282 
ILE   CA   C N S 283 
ILE   C    C N N 284 
ILE   O    O N N 285 
ILE   CB   C N S 286 
ILE   CG1  C N N 287 
ILE   CG2  C N N 288 
ILE   CD1  C N N 289 
ILE   OXT  O N N 290 
ILE   H    H N N 291 
ILE   H2   H N N 292 
ILE   HA   H N N 293 
ILE   HB   H N N 294 
ILE   HG12 H N N 295 
ILE   HG13 H N N 296 
ILE   HG21 H N N 297 
ILE   HG22 H N N 298 
ILE   HG23 H N N 299 
ILE   HD11 H N N 300 
ILE   HD12 H N N 301 
ILE   HD13 H N N 302 
ILE   HXT  H N N 303 
LEU   N    N N N 304 
LEU   CA   C N S 305 
LEU   C    C N N 306 
LEU   O    O N N 307 
LEU   CB   C N N 308 
LEU   CG   C N N 309 
LEU   CD1  C N N 310 
LEU   CD2  C N N 311 
LEU   OXT  O N N 312 
LEU   H    H N N 313 
LEU   H2   H N N 314 
LEU   HA   H N N 315 
LEU   HB2  H N N 316 
LEU   HB3  H N N 317 
LEU   HG   H N N 318 
LEU   HD11 H N N 319 
LEU   HD12 H N N 320 
LEU   HD13 H N N 321 
LEU   HD21 H N N 322 
LEU   HD22 H N N 323 
LEU   HD23 H N N 324 
LEU   HXT  H N N 325 
LYS   N    N N N 326 
LYS   CA   C N S 327 
LYS   C    C N N 328 
LYS   O    O N N 329 
LYS   CB   C N N 330 
LYS   CG   C N N 331 
LYS   CD   C N N 332 
LYS   CE   C N N 333 
LYS   NZ   N N N 334 
LYS   OXT  O N N 335 
LYS   H    H N N 336 
LYS   H2   H N N 337 
LYS   HA   H N N 338 
LYS   HB2  H N N 339 
LYS   HB3  H N N 340 
LYS   HG2  H N N 341 
LYS   HG3  H N N 342 
LYS   HD2  H N N 343 
LYS   HD3  H N N 344 
LYS   HE2  H N N 345 
LYS   HE3  H N N 346 
LYS   HZ1  H N N 347 
LYS   HZ2  H N N 348 
LYS   HZ3  H N N 349 
LYS   HXT  H N N 350 
MET   N    N N N 351 
MET   CA   C N S 352 
MET   C    C N N 353 
MET   O    O N N 354 
MET   CB   C N N 355 
MET   CG   C N N 356 
MET   SD   S N N 357 
MET   CE   C N N 358 
MET   OXT  O N N 359 
MET   H    H N N 360 
MET   H2   H N N 361 
MET   HA   H N N 362 
MET   HB2  H N N 363 
MET   HB3  H N N 364 
MET   HG2  H N N 365 
MET   HG3  H N N 366 
MET   HE1  H N N 367 
MET   HE2  H N N 368 
MET   HE3  H N N 369 
MET   HXT  H N N 370 
PHE   N    N N N 371 
PHE   CA   C N S 372 
PHE   C    C N N 373 
PHE   O    O N N 374 
PHE   CB   C N N 375 
PHE   CG   C Y N 376 
PHE   CD1  C Y N 377 
PHE   CD2  C Y N 378 
PHE   CE1  C Y N 379 
PHE   CE2  C Y N 380 
PHE   CZ   C Y N 381 
PHE   OXT  O N N 382 
PHE   H    H N N 383 
PHE   H2   H N N 384 
PHE   HA   H N N 385 
PHE   HB2  H N N 386 
PHE   HB3  H N N 387 
PHE   HD1  H N N 388 
PHE   HD2  H N N 389 
PHE   HE1  H N N 390 
PHE   HE2  H N N 391 
PHE   HZ   H N N 392 
PHE   HXT  H N N 393 
PRO   N    N N N 394 
PRO   CA   C N S 395 
PRO   C    C N N 396 
PRO   O    O N N 397 
PRO   CB   C N N 398 
PRO   CG   C N N 399 
PRO   CD   C N N 400 
PRO   OXT  O N N 401 
PRO   H    H N N 402 
PRO   HA   H N N 403 
PRO   HB2  H N N 404 
PRO   HB3  H N N 405 
PRO   HG2  H N N 406 
PRO   HG3  H N N 407 
PRO   HD2  H N N 408 
PRO   HD3  H N N 409 
PRO   HXT  H N N 410 
SER   N    N N N 411 
SER   CA   C N S 412 
SER   C    C N N 413 
SER   O    O N N 414 
SER   CB   C N N 415 
SER   OG   O N N 416 
SER   OXT  O N N 417 
SER   H    H N N 418 
SER   H2   H N N 419 
SER   HA   H N N 420 
SER   HB2  H N N 421 
SER   HB3  H N N 422 
SER   HG   H N N 423 
SER   HXT  H N N 424 
THR   N    N N N 425 
THR   CA   C N S 426 
THR   C    C N N 427 
THR   O    O N N 428 
THR   CB   C N R 429 
THR   OG1  O N N 430 
THR   CG2  C N N 431 
THR   OXT  O N N 432 
THR   H    H N N 433 
THR   H2   H N N 434 
THR   HA   H N N 435 
THR   HB   H N N 436 
THR   HG1  H N N 437 
THR   HG21 H N N 438 
THR   HG22 H N N 439 
THR   HG23 H N N 440 
THR   HXT  H N N 441 
TRP   N    N N N 442 
TRP   CA   C N S 443 
TRP   C    C N N 444 
TRP   O    O N N 445 
TRP   CB   C N N 446 
TRP   CG   C Y N 447 
TRP   CD1  C Y N 448 
TRP   CD2  C Y N 449 
TRP   NE1  N Y N 450 
TRP   CE2  C Y N 451 
TRP   CE3  C Y N 452 
TRP   CZ2  C Y N 453 
TRP   CZ3  C Y N 454 
TRP   CH2  C Y N 455 
TRP   OXT  O N N 456 
TRP   H    H N N 457 
TRP   H2   H N N 458 
TRP   HA   H N N 459 
TRP   HB2  H N N 460 
TRP   HB3  H N N 461 
TRP   HD1  H N N 462 
TRP   HE1  H N N 463 
TRP   HE3  H N N 464 
TRP   HZ2  H N N 465 
TRP   HZ3  H N N 466 
TRP   HH2  H N N 467 
TRP   HXT  H N N 468 
TYR   N    N N N 469 
TYR   CA   C N S 470 
TYR   C    C N N 471 
TYR   O    O N N 472 
TYR   CB   C N N 473 
TYR   CG   C Y N 474 
TYR   CD1  C Y N 475 
TYR   CD2  C Y N 476 
TYR   CE1  C Y N 477 
TYR   CE2  C Y N 478 
TYR   CZ   C Y N 479 
TYR   OH   O N N 480 
TYR   OXT  O N N 481 
TYR   H    H N N 482 
TYR   H2   H N N 483 
TYR   HA   H N N 484 
TYR   HB2  H N N 485 
TYR   HB3  H N N 486 
TYR   HD1  H N N 487 
TYR   HD2  H N N 488 
TYR   HE1  H N N 489 
TYR   HE2  H N N 490 
TYR   HH   H N N 491 
TYR   HXT  H N N 492 
VAL   N    N N N 493 
VAL   CA   C N S 494 
VAL   C    C N N 495 
VAL   O    O N N 496 
VAL   CB   C N N 497 
VAL   CG1  C N N 498 
VAL   CG2  C N N 499 
VAL   OXT  O N N 500 
VAL   H    H N N 501 
VAL   H2   H N N 502 
VAL   HA   H N N 503 
VAL   HB   H N N 504 
VAL   HG11 H N N 505 
VAL   HG12 H N N 506 
VAL   HG13 H N N 507 
VAL   HG21 H N N 508 
VAL   HG22 H N N 509 
VAL   HG23 H N N 510 
VAL   HXT  H N N 511 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1APU C20 C21  doub Y N 1   
A1APU C20 C19  sing Y N 2   
A1APU C21 C22  sing Y N 3   
A1APU C19 C18  doub Y N 4   
A1APU C22 C23  doub Y N 5   
A1APU C24 N25  doub Y N 6   
A1APU C24 C15  sing Y N 7   
A1APU C18 C23  sing Y N 8   
A1APU C18 C17  sing N N 9   
A1APU O16 C15  sing N N 10  
A1APU O16 C17  sing N N 11  
A1APU N25 C26  sing Y N 12  
A1APU C15 C14  doub Y N 13  
A1APU C07 S08  sing N N 14  
A1APU C07 C06  sing N N 15  
A1APU C26 C13  doub Y N 16  
A1APU C14 C13  sing Y N 17  
A1APU S08 C09  sing N N 18  
A1APU C06 O33  doub N N 19  
A1APU C06 N05  sing N N 20  
A1APU C13 C12  sing N N 21  
A1APU O44 C03  doub N N 22  
A1APU C01 N02  sing N N 23  
A1APU N05 C04  sing N N 24  
A1APU C03 N02  sing N N 25  
A1APU C03 C04  sing N N 26  
A1APU C09 C12  doub Y N 27  
A1APU C09 C10  sing Y N 28  
A1APU C12 C27  sing Y N 29  
A1APU C04 C34  sing N N 30  
A1APU C34 C35  sing N N 31  
A1APU C39 O38  sing N N 32  
A1APU C10 C11  doub Y N 33  
A1APU C32 C27  doub Y N 34  
A1APU C32 C31  sing Y N 35  
A1APU C27 C28  sing Y N 36  
A1APU C36 C35  doub Y N 37  
A1APU C36 C37  sing Y N 38  
A1APU C35 C43  sing Y N 39  
A1APU O38 C37  sing N N 40  
A1APU C37 C40  doub Y N 41  
A1APU C11 C28  sing Y N 42  
A1APU C28 C29  doub Y N 43  
A1APU C31 C30  doub Y N 44  
A1APU C43 C42  doub Y N 45  
A1APU C40 C42  sing Y N 46  
A1APU C40 C41  sing N N 47  
A1APU C30 C29  sing Y N 48  
A1APU C14 H1   sing N N 49  
A1APU C11 H2   sing N N 50  
A1APU C10 H3   sing N N 51  
A1APU C17 H4   sing N N 52  
A1APU C17 H5   sing N N 53  
A1APU C01 H6   sing N N 54  
A1APU C01 H7   sing N N 55  
A1APU C01 H8   sing N N 56  
A1APU N02 H9   sing N N 57  
A1APU C04 H10  sing N N 58  
A1APU N05 H11  sing N N 59  
A1APU C07 H12  sing N N 60  
A1APU C07 H13  sing N N 61  
A1APU C19 H14  sing N N 62  
A1APU C20 H15  sing N N 63  
A1APU C21 H16  sing N N 64  
A1APU C22 H17  sing N N 65  
A1APU C23 H18  sing N N 66  
A1APU C24 H19  sing N N 67  
A1APU C26 H20  sing N N 68  
A1APU C29 H21  sing N N 69  
A1APU C30 H22  sing N N 70  
A1APU C31 H23  sing N N 71  
A1APU C32 H24  sing N N 72  
A1APU C34 H25  sing N N 73  
A1APU C34 H26  sing N N 74  
A1APU C36 H27  sing N N 75  
A1APU C39 H28  sing N N 76  
A1APU C39 H29  sing N N 77  
A1APU C39 H30  sing N N 78  
A1APU C41 H31  sing N N 79  
A1APU C41 H32  sing N N 80  
A1APU C41 H33  sing N N 81  
A1APU C42 H34  sing N N 82  
A1APU C43 H35  sing N N 83  
A1APV C20 C21  doub Y N 84  
A1APV C20 C19  sing Y N 85  
A1APV C21 C16  sing Y N 86  
A1APV O22 C19  sing N N 87  
A1APV C19 C18  doub Y N 88  
A1APV C16 C15  sing N N 89  
A1APV C16 C17  doub Y N 90  
A1APV C15 C14  sing N N 91  
A1APV C18 C17  sing Y N 92  
A1APV C18 O23  sing N N 93  
A1APV C17 C07  sing N N 94  
A1APV C01 C02  doub N N 95  
A1APV C14 N04  sing N N 96  
A1APV C14 C13  sing N N 97  
A1APV C02 C03  sing N N 98  
A1APV C11 C12  sing N N 99  
A1APV C11 C09  sing N N 100 
A1APV C12 C13  sing N N 101 
A1APV N04 C03  sing N N 102 
A1APV N04 C05  sing N N 103 
A1APV C07 C13  sing N N 104 
A1APV C07 C08  sing N N 105 
A1APV C07 C06  sing N N 106 
A1APV C13 O24  sing N N 107 
A1APV O23 C08  sing N N 108 
A1APV C09 C08  sing N N 109 
A1APV C09 O10  doub N N 110 
A1APV C05 C06  sing N N 111 
A1APV C01 H011 sing N N 112 
A1APV C01 H012 sing N N 113 
A1APV C02 H021 sing N N 114 
A1APV C03 H032 sing N N 115 
A1APV C03 H031 sing N N 116 
A1APV C05 H051 sing N N 117 
A1APV C05 H052 sing N N 118 
A1APV C06 H061 sing N N 119 
A1APV C06 H062 sing N N 120 
A1APV C08 H081 sing N N 121 
A1APV C11 H112 sing N N 122 
A1APV C11 H111 sing N N 123 
A1APV C12 H121 sing N N 124 
A1APV C12 H122 sing N N 125 
A1APV C14 H141 sing N N 126 
A1APV C15 H152 sing N N 127 
A1APV C15 H151 sing N N 128 
A1APV C20 H201 sing N N 129 
A1APV C21 H211 sing N N 130 
A1APV O22 H221 sing N N 131 
A1APV O24 H241 sing N N 132 
ALA   N   CA   sing N N 133 
ALA   N   H    sing N N 134 
ALA   N   H2   sing N N 135 
ALA   CA  C    sing N N 136 
ALA   CA  CB   sing N N 137 
ALA   CA  HA   sing N N 138 
ALA   C   O    doub N N 139 
ALA   C   OXT  sing N N 140 
ALA   CB  HB1  sing N N 141 
ALA   CB  HB2  sing N N 142 
ALA   CB  HB3  sing N N 143 
ALA   OXT HXT  sing N N 144 
ARG   N   CA   sing N N 145 
ARG   N   H    sing N N 146 
ARG   N   H2   sing N N 147 
ARG   CA  C    sing N N 148 
ARG   CA  CB   sing N N 149 
ARG   CA  HA   sing N N 150 
ARG   C   O    doub N N 151 
ARG   C   OXT  sing N N 152 
ARG   CB  CG   sing N N 153 
ARG   CB  HB2  sing N N 154 
ARG   CB  HB3  sing N N 155 
ARG   CG  CD   sing N N 156 
ARG   CG  HG2  sing N N 157 
ARG   CG  HG3  sing N N 158 
ARG   CD  NE   sing N N 159 
ARG   CD  HD2  sing N N 160 
ARG   CD  HD3  sing N N 161 
ARG   NE  CZ   sing N N 162 
ARG   NE  HE   sing N N 163 
ARG   CZ  NH1  sing N N 164 
ARG   CZ  NH2  doub N N 165 
ARG   NH1 HH11 sing N N 166 
ARG   NH1 HH12 sing N N 167 
ARG   NH2 HH21 sing N N 168 
ARG   NH2 HH22 sing N N 169 
ARG   OXT HXT  sing N N 170 
ASN   N   CA   sing N N 171 
ASN   N   H    sing N N 172 
ASN   N   H2   sing N N 173 
ASN   CA  C    sing N N 174 
ASN   CA  CB   sing N N 175 
ASN   CA  HA   sing N N 176 
ASN   C   O    doub N N 177 
ASN   C   OXT  sing N N 178 
ASN   CB  CG   sing N N 179 
ASN   CB  HB2  sing N N 180 
ASN   CB  HB3  sing N N 181 
ASN   CG  OD1  doub N N 182 
ASN   CG  ND2  sing N N 183 
ASN   ND2 HD21 sing N N 184 
ASN   ND2 HD22 sing N N 185 
ASN   OXT HXT  sing N N 186 
ASP   N   CA   sing N N 187 
ASP   N   H    sing N N 188 
ASP   N   H2   sing N N 189 
ASP   CA  C    sing N N 190 
ASP   CA  CB   sing N N 191 
ASP   CA  HA   sing N N 192 
ASP   C   O    doub N N 193 
ASP   C   OXT  sing N N 194 
ASP   CB  CG   sing N N 195 
ASP   CB  HB2  sing N N 196 
ASP   CB  HB3  sing N N 197 
ASP   CG  OD1  doub N N 198 
ASP   CG  OD2  sing N N 199 
ASP   OD2 HD2  sing N N 200 
ASP   OXT HXT  sing N N 201 
CYS   N   CA   sing N N 202 
CYS   N   H    sing N N 203 
CYS   N   H2   sing N N 204 
CYS   CA  C    sing N N 205 
CYS   CA  CB   sing N N 206 
CYS   CA  HA   sing N N 207 
CYS   C   O    doub N N 208 
CYS   C   OXT  sing N N 209 
CYS   CB  SG   sing N N 210 
CYS   CB  HB2  sing N N 211 
CYS   CB  HB3  sing N N 212 
CYS   SG  HG   sing N N 213 
CYS   OXT HXT  sing N N 214 
GLN   N   CA   sing N N 215 
GLN   N   H    sing N N 216 
GLN   N   H2   sing N N 217 
GLN   CA  C    sing N N 218 
GLN   CA  CB   sing N N 219 
GLN   CA  HA   sing N N 220 
GLN   C   O    doub N N 221 
GLN   C   OXT  sing N N 222 
GLN   CB  CG   sing N N 223 
GLN   CB  HB2  sing N N 224 
GLN   CB  HB3  sing N N 225 
GLN   CG  CD   sing N N 226 
GLN   CG  HG2  sing N N 227 
GLN   CG  HG3  sing N N 228 
GLN   CD  OE1  doub N N 229 
GLN   CD  NE2  sing N N 230 
GLN   NE2 HE21 sing N N 231 
GLN   NE2 HE22 sing N N 232 
GLN   OXT HXT  sing N N 233 
GLU   N   CA   sing N N 234 
GLU   N   H    sing N N 235 
GLU   N   H2   sing N N 236 
GLU   CA  C    sing N N 237 
GLU   CA  CB   sing N N 238 
GLU   CA  HA   sing N N 239 
GLU   C   O    doub N N 240 
GLU   C   OXT  sing N N 241 
GLU   CB  CG   sing N N 242 
GLU   CB  HB2  sing N N 243 
GLU   CB  HB3  sing N N 244 
GLU   CG  CD   sing N N 245 
GLU   CG  HG2  sing N N 246 
GLU   CG  HG3  sing N N 247 
GLU   CD  OE1  doub N N 248 
GLU   CD  OE2  sing N N 249 
GLU   OE2 HE2  sing N N 250 
GLU   OXT HXT  sing N N 251 
GLY   N   CA   sing N N 252 
GLY   N   H    sing N N 253 
GLY   N   H2   sing N N 254 
GLY   CA  C    sing N N 255 
GLY   CA  HA2  sing N N 256 
GLY   CA  HA3  sing N N 257 
GLY   C   O    doub N N 258 
GLY   C   OXT  sing N N 259 
GLY   OXT HXT  sing N N 260 
HIS   N   CA   sing N N 261 
HIS   N   H    sing N N 262 
HIS   N   H2   sing N N 263 
HIS   CA  C    sing N N 264 
HIS   CA  CB   sing N N 265 
HIS   CA  HA   sing N N 266 
HIS   C   O    doub N N 267 
HIS   C   OXT  sing N N 268 
HIS   CB  CG   sing N N 269 
HIS   CB  HB2  sing N N 270 
HIS   CB  HB3  sing N N 271 
HIS   CG  ND1  sing Y N 272 
HIS   CG  CD2  doub Y N 273 
HIS   ND1 CE1  doub Y N 274 
HIS   ND1 HD1  sing N N 275 
HIS   CD2 NE2  sing Y N 276 
HIS   CD2 HD2  sing N N 277 
HIS   CE1 NE2  sing Y N 278 
HIS   CE1 HE1  sing N N 279 
HIS   NE2 HE2  sing N N 280 
HIS   OXT HXT  sing N N 281 
ILE   N   CA   sing N N 282 
ILE   N   H    sing N N 283 
ILE   N   H2   sing N N 284 
ILE   CA  C    sing N N 285 
ILE   CA  CB   sing N N 286 
ILE   CA  HA   sing N N 287 
ILE   C   O    doub N N 288 
ILE   C   OXT  sing N N 289 
ILE   CB  CG1  sing N N 290 
ILE   CB  CG2  sing N N 291 
ILE   CB  HB   sing N N 292 
ILE   CG1 CD1  sing N N 293 
ILE   CG1 HG12 sing N N 294 
ILE   CG1 HG13 sing N N 295 
ILE   CG2 HG21 sing N N 296 
ILE   CG2 HG22 sing N N 297 
ILE   CG2 HG23 sing N N 298 
ILE   CD1 HD11 sing N N 299 
ILE   CD1 HD12 sing N N 300 
ILE   CD1 HD13 sing N N 301 
ILE   OXT HXT  sing N N 302 
LEU   N   CA   sing N N 303 
LEU   N   H    sing N N 304 
LEU   N   H2   sing N N 305 
LEU   CA  C    sing N N 306 
LEU   CA  CB   sing N N 307 
LEU   CA  HA   sing N N 308 
LEU   C   O    doub N N 309 
LEU   C   OXT  sing N N 310 
LEU   CB  CG   sing N N 311 
LEU   CB  HB2  sing N N 312 
LEU   CB  HB3  sing N N 313 
LEU   CG  CD1  sing N N 314 
LEU   CG  CD2  sing N N 315 
LEU   CG  HG   sing N N 316 
LEU   CD1 HD11 sing N N 317 
LEU   CD1 HD12 sing N N 318 
LEU   CD1 HD13 sing N N 319 
LEU   CD2 HD21 sing N N 320 
LEU   CD2 HD22 sing N N 321 
LEU   CD2 HD23 sing N N 322 
LEU   OXT HXT  sing N N 323 
LYS   N   CA   sing N N 324 
LYS   N   H    sing N N 325 
LYS   N   H2   sing N N 326 
LYS   CA  C    sing N N 327 
LYS   CA  CB   sing N N 328 
LYS   CA  HA   sing N N 329 
LYS   C   O    doub N N 330 
LYS   C   OXT  sing N N 331 
LYS   CB  CG   sing N N 332 
LYS   CB  HB2  sing N N 333 
LYS   CB  HB3  sing N N 334 
LYS   CG  CD   sing N N 335 
LYS   CG  HG2  sing N N 336 
LYS   CG  HG3  sing N N 337 
LYS   CD  CE   sing N N 338 
LYS   CD  HD2  sing N N 339 
LYS   CD  HD3  sing N N 340 
LYS   CE  NZ   sing N N 341 
LYS   CE  HE2  sing N N 342 
LYS   CE  HE3  sing N N 343 
LYS   NZ  HZ1  sing N N 344 
LYS   NZ  HZ2  sing N N 345 
LYS   NZ  HZ3  sing N N 346 
LYS   OXT HXT  sing N N 347 
MET   N   CA   sing N N 348 
MET   N   H    sing N N 349 
MET   N   H2   sing N N 350 
MET   CA  C    sing N N 351 
MET   CA  CB   sing N N 352 
MET   CA  HA   sing N N 353 
MET   C   O    doub N N 354 
MET   C   OXT  sing N N 355 
MET   CB  CG   sing N N 356 
MET   CB  HB2  sing N N 357 
MET   CB  HB3  sing N N 358 
MET   CG  SD   sing N N 359 
MET   CG  HG2  sing N N 360 
MET   CG  HG3  sing N N 361 
MET   SD  CE   sing N N 362 
MET   CE  HE1  sing N N 363 
MET   CE  HE2  sing N N 364 
MET   CE  HE3  sing N N 365 
MET   OXT HXT  sing N N 366 
PHE   N   CA   sing N N 367 
PHE   N   H    sing N N 368 
PHE   N   H2   sing N N 369 
PHE   CA  C    sing N N 370 
PHE   CA  CB   sing N N 371 
PHE   CA  HA   sing N N 372 
PHE   C   O    doub N N 373 
PHE   C   OXT  sing N N 374 
PHE   CB  CG   sing N N 375 
PHE   CB  HB2  sing N N 376 
PHE   CB  HB3  sing N N 377 
PHE   CG  CD1  doub Y N 378 
PHE   CG  CD2  sing Y N 379 
PHE   CD1 CE1  sing Y N 380 
PHE   CD1 HD1  sing N N 381 
PHE   CD2 CE2  doub Y N 382 
PHE   CD2 HD2  sing N N 383 
PHE   CE1 CZ   doub Y N 384 
PHE   CE1 HE1  sing N N 385 
PHE   CE2 CZ   sing Y N 386 
PHE   CE2 HE2  sing N N 387 
PHE   CZ  HZ   sing N N 388 
PHE   OXT HXT  sing N N 389 
PRO   N   CA   sing N N 390 
PRO   N   CD   sing N N 391 
PRO   N   H    sing N N 392 
PRO   CA  C    sing N N 393 
PRO   CA  CB   sing N N 394 
PRO   CA  HA   sing N N 395 
PRO   C   O    doub N N 396 
PRO   C   OXT  sing N N 397 
PRO   CB  CG   sing N N 398 
PRO   CB  HB2  sing N N 399 
PRO   CB  HB3  sing N N 400 
PRO   CG  CD   sing N N 401 
PRO   CG  HG2  sing N N 402 
PRO   CG  HG3  sing N N 403 
PRO   CD  HD2  sing N N 404 
PRO   CD  HD3  sing N N 405 
PRO   OXT HXT  sing N N 406 
SER   N   CA   sing N N 407 
SER   N   H    sing N N 408 
SER   N   H2   sing N N 409 
SER   CA  C    sing N N 410 
SER   CA  CB   sing N N 411 
SER   CA  HA   sing N N 412 
SER   C   O    doub N N 413 
SER   C   OXT  sing N N 414 
SER   CB  OG   sing N N 415 
SER   CB  HB2  sing N N 416 
SER   CB  HB3  sing N N 417 
SER   OG  HG   sing N N 418 
SER   OXT HXT  sing N N 419 
THR   N   CA   sing N N 420 
THR   N   H    sing N N 421 
THR   N   H2   sing N N 422 
THR   CA  C    sing N N 423 
THR   CA  CB   sing N N 424 
THR   CA  HA   sing N N 425 
THR   C   O    doub N N 426 
THR   C   OXT  sing N N 427 
THR   CB  OG1  sing N N 428 
THR   CB  CG2  sing N N 429 
THR   CB  HB   sing N N 430 
THR   OG1 HG1  sing N N 431 
THR   CG2 HG21 sing N N 432 
THR   CG2 HG22 sing N N 433 
THR   CG2 HG23 sing N N 434 
THR   OXT HXT  sing N N 435 
TRP   N   CA   sing N N 436 
TRP   N   H    sing N N 437 
TRP   N   H2   sing N N 438 
TRP   CA  C    sing N N 439 
TRP   CA  CB   sing N N 440 
TRP   CA  HA   sing N N 441 
TRP   C   O    doub N N 442 
TRP   C   OXT  sing N N 443 
TRP   CB  CG   sing N N 444 
TRP   CB  HB2  sing N N 445 
TRP   CB  HB3  sing N N 446 
TRP   CG  CD1  doub Y N 447 
TRP   CG  CD2  sing Y N 448 
TRP   CD1 NE1  sing Y N 449 
TRP   CD1 HD1  sing N N 450 
TRP   CD2 CE2  doub Y N 451 
TRP   CD2 CE3  sing Y N 452 
TRP   NE1 CE2  sing Y N 453 
TRP   NE1 HE1  sing N N 454 
TRP   CE2 CZ2  sing Y N 455 
TRP   CE3 CZ3  doub Y N 456 
TRP   CE3 HE3  sing N N 457 
TRP   CZ2 CH2  doub Y N 458 
TRP   CZ2 HZ2  sing N N 459 
TRP   CZ3 CH2  sing Y N 460 
TRP   CZ3 HZ3  sing N N 461 
TRP   CH2 HH2  sing N N 462 
TRP   OXT HXT  sing N N 463 
TYR   N   CA   sing N N 464 
TYR   N   H    sing N N 465 
TYR   N   H2   sing N N 466 
TYR   CA  C    sing N N 467 
TYR   CA  CB   sing N N 468 
TYR   CA  HA   sing N N 469 
TYR   C   O    doub N N 470 
TYR   C   OXT  sing N N 471 
TYR   CB  CG   sing N N 472 
TYR   CB  HB2  sing N N 473 
TYR   CB  HB3  sing N N 474 
TYR   CG  CD1  doub Y N 475 
TYR   CG  CD2  sing Y N 476 
TYR   CD1 CE1  sing Y N 477 
TYR   CD1 HD1  sing N N 478 
TYR   CD2 CE2  doub Y N 479 
TYR   CD2 HD2  sing N N 480 
TYR   CE1 CZ   doub Y N 481 
TYR   CE1 HE1  sing N N 482 
TYR   CE2 CZ   sing Y N 483 
TYR   CE2 HE2  sing N N 484 
TYR   CZ  OH   sing N N 485 
TYR   OH  HH   sing N N 486 
TYR   OXT HXT  sing N N 487 
VAL   N   CA   sing N N 488 
VAL   N   H    sing N N 489 
VAL   N   H2   sing N N 490 
VAL   CA  C    sing N N 491 
VAL   CA  CB   sing N N 492 
VAL   CA  HA   sing N N 493 
VAL   C   O    doub N N 494 
VAL   C   OXT  sing N N 495 
VAL   CB  CG1  sing N N 496 
VAL   CB  CG2  sing N N 497 
VAL   CB  HB   sing N N 498 
VAL   CG1 HG11 sing N N 499 
VAL   CG1 HG12 sing N N 500 
VAL   CG1 HG13 sing N N 501 
VAL   CG2 HG21 sing N N 502 
VAL   CG2 HG22 sing N N 503 
VAL   CG2 HG23 sing N N 504 
VAL   OXT HXT  sing N N 505 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-25 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9BJK 
_em_admin.last_update        2024-07-17 
_em_admin.map_release_date   2024-07-17 
_em_admin.title              'Inactive mu opioid receptor bound to Nb6, naloxone and NAM' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          10090 
_em_entity_assembly_naturalsource.organism             'Mus musculus' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Chan Zuckerberg Initiative' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 A1APU ? ? A1APU ? ? 'SUBJECT OF INVESTIGATION' ? 
2 A1APV ? ? A1APV ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
_atom_sites.entry_id                    9BJK 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . THR   A 1 29  ? 104.571 126.141 80.109  1.00 125.00 ? 29  THR   N N   1 
ATOM   2    C CA  . THR   A 1 29  ? 104.273 126.219 81.534  1.00 125.23 ? 29  THR   N CA  1 
ATOM   3    C C   . THR   A 1 29  ? 103.302 125.121 81.938  1.00 124.93 ? 29  THR   N C   1 
ATOM   4    O O   . THR   A 1 29  ? 102.705 125.172 83.011  1.00 123.37 ? 29  THR   N O   1 
ATOM   5    C CB  . THR   A 1 29  ? 103.677 127.585 81.913  1.00 120.87 ? 29  THR   N CB  1 
ATOM   6    N N   . ILE   A 1 30  ? 103.156 124.121 81.074  1.00 122.95 ? 30  ILE   N N   1 
ATOM   7    C CA  . ILE   A 1 30  ? 102.177 123.056 81.253  1.00 117.62 ? 30  ILE   N CA  1 
ATOM   8    C C   . ILE   A 1 30  ? 102.918 121.738 81.413  1.00 116.41 ? 30  ILE   N C   1 
ATOM   9    O O   . ILE   A 1 30  ? 103.753 121.385 80.573  1.00 119.49 ? 30  ILE   N O   1 
ATOM   10   C CB  . ILE   A 1 30  ? 101.194 122.987 80.071  1.00 110.65 ? 30  ILE   N CB  1 
ATOM   11   N N   . PHE   A 1 31  ? 102.612 121.018 82.497  1.00 110.29 ? 31  PHE   N N   1 
ATOM   12   C CA  . PHE   A 1 31  ? 103.171 119.684 82.687  1.00 105.71 ? 31  PHE   N CA  1 
ATOM   13   C C   . PHE   A 1 31  ? 102.712 118.739 81.587  1.00 105.90 ? 31  PHE   N C   1 
ATOM   14   O O   . PHE   A 1 31  ? 103.513 117.970 81.043  1.00 109.78 ? 31  PHE   N O   1 
ATOM   15   C CB  . PHE   A 1 31  ? 102.774 119.144 84.060  1.00 101.34 ? 31  PHE   N CB  1 
ATOM   16   C CG  . PHE   A 1 31  ? 103.360 117.800 84.379  1.00 100.61 ? 31  PHE   N CG  1 
ATOM   17   C CD1 . PHE   A 1 31  ? 104.669 117.503 84.056  1.00 96.27  ? 31  PHE   N CD1 1 
ATOM   18   C CD2 . PHE   A 1 31  ? 102.595 116.833 85.008  1.00 95.55  ? 31  PHE   N CD2 1 
ATOM   19   C CE1 . PHE   A 1 31  ? 105.200 116.267 84.349  1.00 91.54  ? 31  PHE   N CE1 1 
ATOM   20   C CE2 . PHE   A 1 31  ? 103.124 115.598 85.300  1.00 89.03  ? 31  PHE   N CE2 1 
ATOM   21   C CZ  . PHE   A 1 31  ? 104.426 115.316 84.971  1.00 87.88  ? 31  PHE   N CZ  1 
ATOM   22   N N   . ARG   A 1 32  ? 101.426 118.783 81.250  1.00 100.91 ? 32  ARG   N N   1 
ATOM   23   C CA  . ARG   A 1 32  ? 100.869 118.026 80.140  1.00 100.41 ? 32  ARG   N CA  1 
ATOM   24   C C   . ARG   A 1 32  ? 99.429  118.462 79.946  1.00 96.37  ? 32  ARG   N C   1 
ATOM   25   O O   . ARG   A 1 32  ? 98.708  118.665 80.924  1.00 97.24  ? 32  ARG   N O   1 
ATOM   26   C CB  . ARG   A 1 32  ? 100.937 116.515 80.400  1.00 93.62  ? 32  ARG   N CB  1 
ATOM   27   N N   . LEU   A 1 33  ? 99.013  118.601 78.692  1.00 95.67  ? 33  LEU   N N   1 
ATOM   28   C CA  . LEU   A 1 33  ? 97.622  118.878 78.366  1.00 97.27  ? 33  LEU   N CA  1 
ATOM   29   C C   . LEU   A 1 33  ? 96.959  117.574 77.949  1.00 98.27  ? 33  LEU   N C   1 
ATOM   30   O O   . LEU   A 1 33  ? 97.481  116.849 77.098  1.00 98.63  ? 33  LEU   N O   1 
ATOM   31   C CB  . LEU   A 1 33  ? 97.497  119.941 77.272  1.00 98.54  ? 33  LEU   N CB  1 
ATOM   32   C CG  . LEU   A 1 33  ? 97.702  119.572 75.808  1.00 102.05 ? 33  LEU   N CG  1 
ATOM   33   C CD1 . LEU   A 1 33  ? 97.228  120.706 74.923  1.00 97.95  ? 33  LEU   N CD1 1 
ATOM   34   C CD2 . LEU   A 1 33  ? 99.162  119.266 75.546  1.00 99.30  ? 33  LEU   N CD2 1 
ATOM   35   N N   . TYR   A 1 34  ? 95.823  117.268 78.571  1.00 97.58  ? 34  TYR   N N   1 
ATOM   36   C CA  . TYR   A 1 34  ? 95.227  115.942 78.465  1.00 95.19  ? 34  TYR   N CA  1 
ATOM   37   C C   . TYR   A 1 34  ? 94.159  115.882 77.379  1.00 98.46  ? 34  TYR   N C   1 
ATOM   38   O O   . TYR   A 1 34  ? 94.262  115.082 76.445  1.00 109.38 ? 34  TYR   N O   1 
ATOM   39   C CB  . TYR   A 1 34  ? 94.652  115.509 79.821  1.00 86.18  ? 34  TYR   N CB  1 
ATOM   40   C CG  . TYR   A 1 34  ? 95.691  115.375 80.913  1.00 83.46  ? 34  TYR   N CG  1 
ATOM   41   C CD1 . TYR   A 1 34  ? 96.108  116.472 81.650  1.00 84.54  ? 34  TYR   N CD1 1 
ATOM   42   C CD2 . TYR   A 1 34  ? 96.272  114.153 81.187  1.00 89.38  ? 34  TYR   N CD2 1 
ATOM   43   C CE1 . TYR   A 1 34  ? 97.063  116.351 82.630  1.00 87.69  ? 34  TYR   N CE1 1 
ATOM   44   C CE2 . TYR   A 1 34  ? 97.228  114.024 82.171  1.00 89.42  ? 34  TYR   N CE2 1 
ATOM   45   C CZ  . TYR   A 1 34  ? 97.618  115.126 82.888  1.00 85.52  ? 34  TYR   N CZ  1 
ATOM   46   O OH  . TYR   A 1 34  ? 98.569  115.005 83.871  1.00 81.60  ? 34  TYR   N OH  1 
ATOM   47   N N   . ASP   A 1 35  ? 93.138  116.723 77.480  1.00 93.97  ? 35  ASP   N N   1 
ATOM   48   C CA  . ASP   A 1 35  ? 92.017  116.696 76.557  1.00 100.16 ? 35  ASP   N CA  1 
ATOM   49   C C   . ASP   A 1 35  ? 91.890  118.030 75.839  1.00 100.20 ? 35  ASP   N C   1 
ATOM   50   O O   . ASP   A 1 35  ? 92.105  119.091 76.434  1.00 104.35 ? 35  ASP   N O   1 
ATOM   51   C CB  . ASP   A 1 35  ? 90.720  116.375 77.292  1.00 102.87 ? 35  ASP   N CB  1 
ATOM   52   C CG  . ASP   A 1 35  ? 90.776  115.045 77.998  1.00 105.54 ? 35  ASP   N CG  1 
ATOM   53   O OD1 . ASP   A 1 35  ? 91.379  114.978 79.088  1.00 99.83  ? 35  ASP   N OD1 1 
ATOM   54   O OD2 . ASP   A 1 35  ? 90.221  114.063 77.466  1.00 112.39 ? 35  ASP   N OD2 1 
ATOM   55   N N   . MET   A 1 36  ? 91.553  117.964 74.554  1.00 101.47 ? 36  MET   N N   1 
ATOM   56   C CA  . MET   A 1 36  ? 91.323  119.135 73.725  1.00 104.31 ? 36  MET   N CA  1 
ATOM   57   C C   . MET   A 1 36  ? 90.024  118.934 72.968  1.00 105.92 ? 36  MET   N C   1 
ATOM   58   O O   . MET   A 1 36  ? 89.674  117.803 72.624  1.00 109.19 ? 36  MET   N O   1 
ATOM   59   C CB  . MET   A 1 36  ? 92.466  119.359 72.731  1.00 106.83 ? 36  MET   N CB  1 
ATOM   60   C CG  . MET   A 1 36  ? 93.779  119.775 73.359  1.00 108.28 ? 36  MET   N CG  1 
ATOM   61   S SD  . MET   A 1 36  ? 95.079  119.877 72.120  1.00 122.21 ? 36  MET   N SD  1 
ATOM   62   C CE  . MET   A 1 36  ? 94.108  120.254 70.663  1.00 102.01 ? 36  MET   N CE  1 
ATOM   63   N N   . GLY   A 1 37  ? 89.310  120.023 72.701  1.00 111.07 ? 37  GLY   N N   1 
ATOM   64   C CA  . GLY   A 1 37  ? 88.050  119.873 71.998  1.00 118.88 ? 37  GLY   N CA  1 
ATOM   65   C C   . GLY   A 1 37  ? 87.586  121.138 71.319  1.00 124.97 ? 37  GLY   N C   1 
ATOM   66   O O   . GLY   A 1 37  ? 88.000  122.248 71.666  1.00 126.65 ? 37  GLY   N O   1 
ATOM   67   N N   . TRP   A 1 38  ? 86.720  120.950 70.328  1.00 130.64 ? 38  TRP   N N   1 
ATOM   68   C CA  . TRP   A 1 38  ? 85.997  122.049 69.689  1.00 139.50 ? 38  TRP   N CA  1 
ATOM   69   C C   . TRP   A 1 38  ? 84.583  122.151 70.259  1.00 146.09 ? 38  TRP   N C   1 
ATOM   70   O O   . TRP   A 1 38  ? 83.588  121.942 69.566  1.00 146.87 ? 38  TRP   N O   1 
ATOM   71   C CB  . TRP   A 1 38  ? 85.961  121.853 68.176  1.00 139.36 ? 38  TRP   N CB  1 
ATOM   72   C CG  . TRP   A 1 38  ? 87.296  121.909 67.501  1.00 142.54 ? 38  TRP   N CG  1 
ATOM   73   C CD1 . TRP   A 1 38  ? 87.997  120.860 66.980  1.00 142.92 ? 38  TRP   N CD1 1 
ATOM   74   C CD2 . TRP   A 1 38  ? 88.083  123.078 67.256  1.00 141.45 ? 38  TRP   N CD2 1 
ATOM   75   N NE1 . TRP   A 1 38  ? 89.175  121.302 66.434  1.00 142.27 ? 38  TRP   N NE1 1 
ATOM   76   C CE2 . TRP   A 1 38  ? 89.252  122.661 66.590  1.00 141.44 ? 38  TRP   N CE2 1 
ATOM   77   C CE3 . TRP   A 1 38  ? 87.916  124.436 67.540  1.00 138.81 ? 38  TRP   N CE3 1 
ATOM   78   C CZ2 . TRP   A 1 38  ? 90.246  123.553 66.203  1.00 138.38 ? 38  TRP   N CZ2 1 
ATOM   79   C CZ3 . TRP   A 1 38  ? 88.903  125.319 67.156  1.00 136.92 ? 38  TRP   N CZ3 1 
ATOM   80   C CH2 . TRP   A 1 38  ? 90.053  124.875 66.494  1.00 137.89 ? 38  TRP   N CH2 1 
ATOM   81   N N   . TYR   A 1 39  ? 84.507  122.469 71.551  1.00 145.14 ? 39  TYR   N N   1 
ATOM   82   C CA  . TYR   A 1 39  ? 83.220  122.524 72.233  1.00 143.40 ? 39  TYR   N CA  1 
ATOM   83   C C   . TYR   A 1 39  ? 82.383  123.692 71.725  1.00 146.30 ? 39  TYR   N C   1 
ATOM   84   O O   . TYR   A 1 39  ? 82.900  124.779 71.454  1.00 144.58 ? 39  TYR   N O   1 
ATOM   85   C CB  . TYR   A 1 39  ? 83.426  122.638 73.743  1.00 133.28 ? 39  TYR   N CB  1 
ATOM   86   N N   . ARG   A 1 40  ? 81.081  123.459 71.598  1.00 145.81 ? 40  ARG   N N   1 
ATOM   87   C CA  . ARG   A 1 40  ? 80.158  124.484 71.124  1.00 141.81 ? 40  ARG   N CA  1 
ATOM   88   C C   . ARG   A 1 40  ? 78.878  124.495 71.954  1.00 136.99 ? 40  ARG   N C   1 
ATOM   89   O O   . ARG   A 1 40  ? 78.207  123.473 72.091  1.00 135.99 ? 40  ARG   N O   1 
ATOM   90   C CB  . ARG   A 1 40  ? 79.824  124.265 69.647  1.00 138.31 ? 40  ARG   N CB  1 
ATOM   91   N N   . LEU   A 1 49  ? 79.581  119.783 73.033  1.00 144.61 ? 49  LEU   N N   1 
ATOM   92   C CA  . LEU   A 1 49  ? 80.847  119.494 72.369  1.00 146.69 ? 49  LEU   N CA  1 
ATOM   93   C C   . LEU   A 1 49  ? 80.619  118.766 71.051  1.00 152.83 ? 49  LEU   N C   1 
ATOM   94   O O   . LEU   A 1 49  ? 79.961  117.727 71.018  1.00 154.08 ? 49  LEU   N O   1 
ATOM   95   C CB  . LEU   A 1 49  ? 81.751  118.660 73.277  1.00 144.17 ? 49  LEU   N CB  1 
ATOM   96   N N   . VAL   A 1 50  ? 81.157  119.326 69.965  1.00 152.39 ? 50  VAL   N N   1 
ATOM   97   C CA  . VAL   A 1 50  ? 81.029  118.686 68.658  1.00 152.74 ? 50  VAL   N CA  1 
ATOM   98   C C   . VAL   A 1 50  ? 81.783  117.362 68.644  1.00 156.79 ? 50  VAL   N C   1 
ATOM   99   O O   . VAL   A 1 50  ? 81.238  116.320 68.260  1.00 157.50 ? 50  VAL   N O   1 
ATOM   100  C CB  . VAL   A 1 50  ? 81.525  119.629 67.547  1.00 142.45 ? 50  VAL   N CB  1 
ATOM   101  N N   . ALA   A 1 51  ? 83.043  117.384 69.076  1.00 153.02 ? 51  ALA   N N   1 
ATOM   102  C CA  . ALA   A 1 51  ? 83.849  116.177 69.214  1.00 142.30 ? 51  ALA   N CA  1 
ATOM   103  C C   . ALA   A 1 51  ? 85.158  116.503 69.918  1.00 133.19 ? 51  ALA   N C   1 
ATOM   104  O O   . ALA   A 1 51  ? 85.854  117.447 69.534  1.00 130.90 ? 51  ALA   N O   1 
ATOM   105  C CB  . ALA   A 1 51  ? 84.124  115.542 67.850  1.00 141.06 ? 51  ALA   N CB  1 
ATOM   106  N N   . SER   A 1 52  ? 85.506  115.731 70.940  1.00 131.57 ? 52  SER   N N   1 
ATOM   107  C CA  . SER   A 1 52  ? 86.729  115.947 71.700  1.00 129.31 ? 52  SER   N CA  1 
ATOM   108  C C   . SER   A 1 52  ? 87.746  114.877 71.326  1.00 127.91 ? 52  SER   N C   1 
ATOM   109  O O   . SER   A 1 52  ? 87.578  113.706 71.682  1.00 130.97 ? 52  SER   N O   1 
ATOM   110  C CB  . SER   A 1 52  ? 86.447  115.916 73.201  1.00 131.16 ? 52  SER   N CB  1 
ATOM   111  N N   . ILE   A 1 53  ? 88.801  115.279 70.626  1.00 121.74 ? 53  ILE   N N   1 
ATOM   112  C CA  . ILE   A 1 53  ? 89.859  114.371 70.202  1.00 118.24 ? 53  ILE   N CA  1 
ATOM   113  C C   . ILE   A 1 53  ? 90.943  114.441 71.269  1.00 118.20 ? 53  ILE   N C   1 
ATOM   114  O O   . ILE   A 1 53  ? 91.810  115.316 71.236  1.00 120.29 ? 53  ILE   N O   1 
ATOM   115  C CB  . ILE   A 1 53  ? 90.398  114.733 68.816  1.00 112.81 ? 53  ILE   N CB  1 
ATOM   116  N N   . THR   A 1 54  ? 90.912  113.498 72.206  1.00 120.54 ? 54  THR   N N   1 
ATOM   117  C CA  . THR   A 1 54  ? 91.763  113.564 73.388  1.00 122.61 ? 54  THR   N CA  1 
ATOM   118  C C   . THR   A 1 54  ? 93.207  113.193 73.070  1.00 127.04 ? 54  THR   N C   1 
ATOM   119  O O   . THR   A 1 54  ? 93.601  113.140 71.902  1.00 126.24 ? 54  THR   N O   1 
ATOM   120  C CB  . THR   A 1 54  ? 91.213  112.656 74.487  1.00 123.17 ? 54  THR   N CB  1 
ATOM   121  O OG1 . THR   A 1 54  ? 91.397  111.285 74.116  1.00 128.56 ? 54  THR   N OG1 1 
ATOM   122  C CG2 . THR   A 1 54  ? 89.732  112.921 74.690  1.00 122.85 ? 54  THR   N CG2 1 
ATOM   123  N N   . SER   A 1 55  ? 94.007  112.946 74.107  1.00 127.79 ? 55  SER   N N   1 
ATOM   124  C CA  . SER   A 1 55  ? 95.426  112.670 73.928  1.00 130.00 ? 55  SER   N CA  1 
ATOM   125  C C   . SER   A 1 55  ? 95.702  111.341 73.236  1.00 135.33 ? 55  SER   N C   1 
ATOM   126  O O   . SER   A 1 55  ? 96.784  111.171 72.662  1.00 138.26 ? 55  SER   N O   1 
ATOM   127  C CB  . SER   A 1 55  ? 96.140  112.692 75.285  1.00 120.58 ? 55  SER   N CB  1 
ATOM   128  N N   . GLY   A 1 56  ? 94.764  110.400 73.276  1.00 133.83 ? 56  GLY   N N   1 
ATOM   129  C CA  . GLY   A 1 56  ? 94.935  109.131 72.597  1.00 129.86 ? 56  GLY   N CA  1 
ATOM   130  C C   . GLY   A 1 56  ? 94.163  109.059 71.297  1.00 130.37 ? 56  GLY   N C   1 
ATOM   131  O O   . GLY   A 1 56  ? 94.489  108.261 70.413  1.00 129.01 ? 56  GLY   N O   1 
ATOM   132  N N   . GLY   A 1 57  ? 93.138  109.895 71.169  1.00 131.00 ? 57  GLY   N N   1 
ATOM   133  C CA  . GLY   A 1 57  ? 92.250  109.863 70.029  1.00 128.78 ? 57  GLY   N CA  1 
ATOM   134  C C   . GLY   A 1 57  ? 90.929  109.166 70.263  1.00 135.94 ? 57  GLY   N C   1 
ATOM   135  O O   . GLY   A 1 57  ? 90.164  108.992 69.308  1.00 140.61 ? 57  GLY   N O   1 
ATOM   136  N N   . SER   A 1 58  ? 90.634  108.769 71.498  1.00 134.32 ? 58  SER   N N   1 
ATOM   137  C CA  . SER   A 1 58  ? 89.413  108.050 71.814  1.00 133.60 ? 58  SER   N CA  1 
ATOM   138  C C   . SER   A 1 58  ? 88.246  109.024 71.960  1.00 139.75 ? 58  SER   N C   1 
ATOM   139  O O   . SER   A 1 58  ? 88.400  110.242 71.839  1.00 139.71 ? 58  SER   N O   1 
ATOM   140  C CB  . SER   A 1 58  ? 89.602  107.222 73.083  1.00 128.38 ? 58  SER   N CB  1 
ATOM   141  N N   . THR   A 1 59  ? 87.062  108.472 72.238  1.00 141.06 ? 59  THR   N N   1 
ATOM   142  C CA  . THR   A 1 59  ? 85.817  109.239 72.318  1.00 141.63 ? 59  THR   N CA  1 
ATOM   143  C C   . THR   A 1 59  ? 85.520  109.945 70.998  1.00 143.17 ? 59  THR   N C   1 
ATOM   144  O O   . THR   A 1 59  ? 85.061  111.089 70.971  1.00 141.18 ? 59  THR   N O   1 
ATOM   145  C CB  . THR   A 1 59  ? 85.851  110.241 73.475  1.00 134.23 ? 59  THR   N CB  1 
ATOM   146  N N   . LYS   A 1 60  ? 85.782  109.255 69.894  1.00 141.57 ? 60  LYS   N N   1 
ATOM   147  C CA  . LYS   A 1 60  ? 85.587  109.824 68.568  1.00 141.46 ? 60  LYS   N CA  1 
ATOM   148  C C   . LYS   A 1 60  ? 84.178  109.552 68.061  1.00 143.13 ? 60  LYS   N C   1 
ATOM   149  O O   . LYS   A 1 60  ? 83.568  108.546 68.417  1.00 142.23 ? 60  LYS   N O   1 
ATOM   150  C CB  . LYS   A 1 60  ? 86.620  109.263 67.588  1.00 136.43 ? 60  LYS   N CB  1 
ATOM   151  N N   . THR   A 1 70  ? 100.461 114.141 65.445  1.00 140.45 ? 70  THR   N N   1 
ATOM   152  C CA  . THR   A 1 70  ? 99.353  115.020 65.800  1.00 143.12 ? 70  THR   N CA  1 
ATOM   153  C C   . THR   A 1 70  ? 99.235  115.162 67.310  1.00 145.08 ? 70  THR   N C   1 
ATOM   154  O O   . THR   A 1 70  ? 98.182  115.529 67.829  1.00 141.20 ? 70  THR   N O   1 
ATOM   155  C CB  . THR   A 1 70  ? 98.017  114.508 65.234  1.00 141.95 ? 70  THR   N CB  1 
ATOM   156  N N   . ILE   A 1 71  ? 100.329 114.866 68.013  1.00 147.32 ? 71  ILE   N N   1 
ATOM   157  C CA  . ILE   A 1 71  ? 100.400 115.012 69.460  1.00 147.75 ? 71  ILE   N CA  1 
ATOM   158  C C   . ILE   A 1 71  ? 101.735 115.651 69.816  1.00 149.10 ? 71  ILE   N C   1 
ATOM   159  O O   . ILE   A 1 71  ? 102.728 115.517 69.098  1.00 146.72 ? 71  ILE   N O   1 
ATOM   160  C CB  . ILE   A 1 71  ? 100.235 113.665 70.199  1.00 139.22 ? 71  ILE   N CB  1 
ATOM   161  N N   . SER   A 1 72  ? 101.750 116.340 70.954  1.00 149.29 ? 72  SER   N N   1 
ATOM   162  C CA  . SER   A 1 72  ? 102.904 117.117 71.384  1.00 148.58 ? 72  SER   N CA  1 
ATOM   163  C C   . SER   A 1 72  ? 103.363 116.624 72.746  1.00 151.74 ? 72  SER   N C   1 
ATOM   164  O O   . SER   A 1 72  ? 102.541 116.415 73.644  1.00 150.87 ? 72  SER   N O   1 
ATOM   165  C CB  . SER   A 1 72  ? 102.571 118.612 71.445  1.00 146.47 ? 72  SER   N CB  1 
ATOM   166  N N   . ARG   A 1 73  ? 104.673 116.441 72.894  1.00 155.81 ? 73  ARG   N N   1 
ATOM   167  C CA  . ARG   A 1 73  ? 105.279 115.978 74.139  1.00 158.03 ? 73  ARG   N CA  1 
ATOM   168  C C   . ARG   A 1 73  ? 106.205 117.069 74.662  1.00 157.53 ? 73  ARG   N C   1 
ATOM   169  O O   . ARG   A 1 73  ? 107.146 117.476 73.971  1.00 154.42 ? 73  ARG   N O   1 
ATOM   170  C CB  . ARG   A 1 73  ? 106.036 114.667 73.928  1.00 154.90 ? 73  ARG   N CB  1 
ATOM   171  N N   . ASP   A 1 74  ? 105.937 117.540 75.878  1.00 154.82 ? 74  ASP   N N   1 
ATOM   172  C CA  . ASP   A 1 74  ? 106.759 118.567 76.499  1.00 150.79 ? 74  ASP   N CA  1 
ATOM   173  C C   . ASP   A 1 74  ? 106.565 118.504 78.006  1.00 142.79 ? 74  ASP   N C   1 
ATOM   174  O O   . ASP   A 1 74  ? 105.481 118.173 78.491  1.00 131.94 ? 74  ASP   N O   1 
ATOM   175  C CB  . ASP   A 1 74  ? 106.412 119.964 75.970  1.00 147.50 ? 74  ASP   N CB  1 
ATOM   176  N N   . ASN   A 1 75  ? 107.629 118.823 78.736  1.00 143.33 ? 75  ASN   N N   1 
ATOM   177  C CA  . ASN   A 1 75  ? 107.591 118.807 80.193  1.00 138.09 ? 75  ASN   N CA  1 
ATOM   178  C C   . ASN   A 1 75  ? 107.775 120.209 80.765  1.00 135.86 ? 75  ASN   N C   1 
ATOM   179  O O   . ASN   A 1 75  ? 107.653 120.418 81.971  1.00 129.61 ? 75  ASN   N O   1 
ATOM   180  C CB  . ASN   A 1 75  ? 108.665 117.867 80.745  1.00 138.08 ? 75  ASN   N CB  1 
ATOM   181  N N   . ALA   A 1 93  ? 80.397  130.959 61.473  1.00 143.33 ? 93  ALA   N N   1 
ATOM   182  C CA  . ALA   A 1 93  ? 80.324  129.901 62.473  1.00 151.29 ? 93  ALA   N CA  1 
ATOM   183  C C   . ALA   A 1 93  ? 81.421  130.067 63.520  1.00 155.78 ? 93  ALA   N C   1 
ATOM   184  O O   . ALA   A 1 93  ? 82.502  129.492 63.397  1.00 154.66 ? 93  ALA   N O   1 
ATOM   185  C CB  . ALA   A 1 93  ? 80.423  128.536 61.808  1.00 147.19 ? 93  ALA   N CB  1 
ATOM   186  N N   . VAL   A 1 94  ? 81.136  130.860 64.552  1.00 154.51 ? 94  VAL   N N   1 
ATOM   187  C CA  . VAL   A 1 94  ? 82.112  131.096 65.608  1.00 150.22 ? 94  VAL   N CA  1 
ATOM   188  C C   . VAL   A 1 94  ? 82.187  129.875 66.513  1.00 150.53 ? 94  VAL   N C   1 
ATOM   189  O O   . VAL   A 1 94  ? 81.169  129.409 67.040  1.00 148.20 ? 94  VAL   N O   1 
ATOM   190  C CB  . VAL   A 1 94  ? 81.749  132.357 66.403  1.00 146.53 ? 94  VAL   N CB  1 
ATOM   191  N N   . TYR   A 1 95  ? 83.397  129.353 66.699  1.00 152.75 ? 95  TYR   N N   1 
ATOM   192  C CA  . TYR   A 1 95  ? 83.629  128.183 67.533  1.00 151.86 ? 95  TYR   N CA  1 
ATOM   193  C C   . TYR   A 1 95  ? 84.849  128.414 68.412  1.00 152.94 ? 95  TYR   N C   1 
ATOM   194  O O   . TYR   A 1 95  ? 85.714  129.236 68.097  1.00 153.90 ? 95  TYR   N O   1 
ATOM   195  C CB  . TYR   A 1 95  ? 83.828  126.918 66.688  1.00 148.16 ? 95  TYR   N CB  1 
ATOM   196  N N   . TYR   A 1 96  ? 84.907  127.686 69.526  1.00 150.10 ? 96  TYR   N N   1 
ATOM   197  C CA  . TYR   A 1 96  ? 86.006  127.794 70.473  1.00 145.94 ? 96  TYR   N CA  1 
ATOM   198  C C   . TYR   A 1 96  ? 86.506  126.405 70.843  1.00 139.56 ? 96  TYR   N C   1 
ATOM   199  O O   . TYR   A 1 96  ? 85.738  125.443 70.904  1.00 138.19 ? 96  TYR   N O   1 
ATOM   200  C CB  . TYR   A 1 96  ? 85.583  128.557 71.736  1.00 142.11 ? 96  TYR   N CB  1 
ATOM   201  N N   . CYS   A 1 97  ? 87.811  126.314 71.092  1.00 138.35 ? 97  CYS   N N   1 
ATOM   202  C CA  . CYS   A 1 97  ? 88.473  125.061 71.439  1.00 133.89 ? 97  CYS   N CA  1 
ATOM   203  C C   . CYS   A 1 97  ? 88.963  125.131 72.879  1.00 128.42 ? 97  CYS   N C   1 
ATOM   204  O O   . CYS   A 1 97  ? 89.797  125.979 73.212  1.00 125.22 ? 97  CYS   N O   1 
ATOM   205  C CB  . CYS   A 1 97  ? 89.639  124.780 70.492  1.00 130.47 ? 97  CYS   N CB  1 
ATOM   206  N N   . ASN   A 1 98  ? 88.455  124.239 73.723  1.00 126.06 ? 98  ASN   N N   1 
ATOM   207  C CA  . ASN   A 1 98  ? 88.866  124.157 75.116  1.00 117.70 ? 98  ASN   N CA  1 
ATOM   208  C C   . ASN   A 1 98  ? 89.973  123.128 75.294  1.00 109.88 ? 98  ASN   N C   1 
ATOM   209  O O   . ASN   A 1 98  ? 90.169  122.238 74.460  1.00 114.19 ? 98  ASN   N O   1 
ATOM   210  C CB  . ASN   A 1 98  ? 87.685  123.803 76.028  1.00 122.22 ? 98  ASN   N CB  1 
ATOM   211  C CG  . ASN   A 1 98  ? 86.995  122.505 75.630  1.00 130.16 ? 98  ASN   N CG  1 
ATOM   212  O OD1 . ASN   A 1 98  ? 87.303  121.908 74.599  1.00 134.18 ? 98  ASN   N OD1 1 
ATOM   213  N ND2 . ASN   A 1 98  ? 86.067  122.054 76.464  1.00 131.83 ? 98  ASN   N ND2 1 
ATOM   214  N N   . ALA   A 1 99  ? 90.689  123.255 76.409  1.00 105.86 ? 99  ALA   N N   1 
ATOM   215  C CA  . ALA   A 1 99  ? 91.721  122.300 76.779  1.00 104.11 ? 99  ALA   N CA  1 
ATOM   216  C C   . ALA   A 1 99  ? 91.660  122.054 78.278  1.00 100.41 ? 99  ALA   N C   1 
ATOM   217  O O   . ALA   A 1 99  ? 91.083  122.836 79.032  1.00 105.45 ? 99  ALA   N O   1 
ATOM   218  C CB  . ALA   A 1 99  ? 93.116  122.788 76.377  1.00 101.81 ? 99  ALA   N CB  1 
ATOM   219  N N   . GLU   A 1 100 ? 92.246  120.940 78.701  1.00 94.83  ? 100 GLU   N N   1 
ATOM   220  C CA  . GLU   A 1 100 ? 92.401  120.629 80.116  1.00 93.58  ? 100 GLU   N CA  1 
ATOM   221  C C   . GLU   A 1 100 ? 93.867  120.343 80.393  1.00 95.63  ? 100 GLU   N C   1 
ATOM   222  O O   . GLU   A 1 100 ? 94.536  119.698 79.583  1.00 97.66  ? 100 GLU   N O   1 
ATOM   223  C CB  . GLU   A 1 100 ? 91.542  119.432 80.529  1.00 94.11  ? 100 GLU   N CB  1 
ATOM   224  C CG  . GLU   A 1 100 ? 90.098  119.508 80.061  1.00 96.33  ? 100 GLU   N CG  1 
ATOM   225  C CD  . GLU   A 1 100 ? 89.356  118.194 80.231  1.00 98.82  ? 100 GLU   N CD  1 
ATOM   226  O OE1 . GLU   A 1 100 ? 89.639  117.470 81.208  1.00 97.88  ? 100 GLU   N OE1 1 
ATOM   227  O OE2 . GLU   A 1 100 ? 88.489  117.883 79.386  1.00 98.89  ? 100 GLU   N OE2 1 
ATOM   228  N N   . TYR   A 1 101 ? 94.376  120.830 81.523  1.00 96.00  ? 101 TYR   N N   1 
ATOM   229  C CA  . TYR   A 1 101 ? 95.792  120.644 81.811  1.00 93.17  ? 101 TYR   N CA  1 
ATOM   230  C C   . TYR   A 1 101 ? 96.065  120.911 83.283  1.00 89.27  ? 101 TYR   N C   1 
ATOM   231  O O   . TYR   A 1 101 ? 95.232  121.472 83.997  1.00 93.01  ? 101 TYR   N O   1 
ATOM   232  C CB  . TYR   A 1 101 ? 96.658  121.550 80.929  1.00 100.00 ? 101 TYR   N CB  1 
ATOM   233  C CG  . TYR   A 1 101 ? 96.436  123.036 81.133  1.00 100.82 ? 101 TYR   N CG  1 
ATOM   234  C CD1 . TYR   A 1 101 ? 95.436  123.705 80.444  1.00 100.12 ? 101 TYR   N CD1 1 
ATOM   235  C CD2 . TYR   A 1 101 ? 97.230  123.772 82.004  1.00 97.04  ? 101 TYR   N CD2 1 
ATOM   236  C CE1 . TYR   A 1 101 ? 95.227  125.057 80.622  1.00 100.50 ? 101 TYR   N CE1 1 
ATOM   237  C CE2 . TYR   A 1 101 ? 97.026  125.121 82.187  1.00 100.23 ? 101 TYR   N CE2 1 
ATOM   238  C CZ  . TYR   A 1 101 ? 96.026  125.758 81.492  1.00 103.20 ? 101 TYR   N CZ  1 
ATOM   239  O OH  . TYR   A 1 101 ? 95.821  127.105 81.671  1.00 105.45 ? 101 TYR   N OH  1 
ATOM   240  N N   . ARG   A 1 102 ? 97.258  120.509 83.719  1.00 85.96  ? 102 ARG   N N   1 
ATOM   241  C CA  . ARG   A 1 102 ? 97.789  120.870 85.025  1.00 88.99  ? 102 ARG   N CA  1 
ATOM   242  C C   . ARG   A 1 102 ? 99.215  121.369 84.853  1.00 100.76 ? 102 ARG   N C   1 
ATOM   243  O O   . ARG   A 1 102 ? 99.952  120.875 83.995  1.00 103.60 ? 102 ARG   N O   1 
ATOM   244  C CB  . ARG   A 1 102 ? 97.771  119.696 86.005  1.00 82.00  ? 102 ARG   N CB  1 
ATOM   245  C CG  . ARG   A 1 102 ? 98.542  118.484 85.537  1.00 82.52  ? 102 ARG   N CG  1 
ATOM   246  C CD  . ARG   A 1 102 ? 98.191  117.264 86.359  1.00 81.15  ? 102 ARG   N CD  1 
ATOM   247  N NE  . ARG   A 1 102 ? 96.881  116.734 86.012  1.00 87.03  ? 102 ARG   N NE  1 
ATOM   248  C CZ  . ARG   A 1 102 ? 95.970  116.361 86.897  1.00 80.93  ? 102 ARG   N CZ  1 
ATOM   249  N NH1 . ARG   A 1 102 ? 96.201  116.433 88.195  1.00 74.67  ? 102 ARG   N NH1 1 
ATOM   250  N NH2 . ARG   A 1 102 ? 94.797  115.909 86.468  1.00 85.60  ? 102 ARG   N NH2 1 
ATOM   251  N N   . THR   A 1 103 ? 99.600  122.354 85.668  1.00 103.33 ? 103 THR   N N   1 
ATOM   252  C CA  . THR   A 1 103 ? 100.924 122.953 85.530  1.00 96.93  ? 103 THR   N CA  1 
ATOM   253  C C   . THR   A 1 103 ? 102.029 121.986 85.943  1.00 95.63  ? 103 THR   N C   1 
ATOM   254  O O   . THR   A 1 103 ? 103.067 121.905 85.279  1.00 96.90  ? 103 THR   N O   1 
ATOM   255  C CB  . THR   A 1 103 ? 101.008 124.239 86.349  1.00 92.50  ? 103 THR   N CB  1 
ATOM   256  N N   . GLY   A 1 104 ? 101.834 121.253 87.042  1.00 93.54  ? 104 GLY   N N   1 
ATOM   257  C CA  . GLY   A 1 104 ? 102.837 120.337 87.544  1.00 86.73  ? 104 GLY   N CA  1 
ATOM   258  C C   . GLY   A 1 104 ? 102.205 119.041 88.011  1.00 82.46  ? 104 GLY   N C   1 
ATOM   259  O O   . GLY   A 1 104 ? 101.021 118.797 87.785  1.00 86.54  ? 104 GLY   N O   1 
ATOM   260  N N   . ILE   A 1 105 ? 103.019 118.203 88.656  1.00 76.73  ? 105 ILE   N N   1 
ATOM   261  C CA  . ILE   A 1 105 ? 102.501 116.944 89.188  1.00 76.58  ? 105 ILE   N CA  1 
ATOM   262  C C   . ILE   A 1 105 ? 101.526 117.209 90.325  1.00 78.83  ? 105 ILE   N C   1 
ATOM   263  O O   . ILE   A 1 105 ? 100.427 116.650 90.370  1.00 88.39  ? 105 ILE   N O   1 
ATOM   264  C CB  . ILE   A 1 105 ? 103.643 116.026 89.653  1.00 73.98  ? 105 ILE   N CB  1 
ATOM   265  C CG1 . ILE   A 1 105 ? 104.590 115.704 88.513  1.00 88.23  ? 105 ILE   N CG1 1 
ATOM   266  C CG2 . ILE   A 1 105 ? 103.094 114.730 90.177  1.00 69.94  ? 105 ILE   N CG2 1 
ATOM   267  C CD1 . ILE   A 1 105 ? 105.487 114.533 88.831  1.00 88.73  ? 105 ILE   N CD1 1 
ATOM   268  N N   . TRP   A 1 106 ? 101.907 118.059 91.248  1.00 71.14  ? 106 TRP   N N   1 
ATOM   269  C CA  . TRP   A 1 106 ? 101.092 118.155 92.445  1.00 69.98  ? 106 TRP   N CA  1 
ATOM   270  C C   . TRP   A 1 106 ? 99.904  119.100 92.282  1.00 77.54  ? 106 TRP   N C   1 
ATOM   271  O O   . TRP   A 1 106 ? 99.135  119.260 93.233  1.00 81.73  ? 106 TRP   N O   1 
ATOM   272  C CB  . TRP   A 1 106 ? 101.959 118.604 93.620  1.00 70.02  ? 106 TRP   N CB  1 
ATOM   273  C CG  . TRP   A 1 106 ? 103.275 117.883 93.728  1.00 71.91  ? 106 TRP   N CG  1 
ATOM   274  C CD1 . TRP   A 1 106 ? 104.504 118.395 93.441  1.00 73.08  ? 106 TRP   N CD1 1 
ATOM   275  C CD2 . TRP   A 1 106 ? 103.493 116.523 94.127  1.00 72.51  ? 106 TRP   N CD2 1 
ATOM   276  N NE1 . TRP   A 1 106 ? 105.473 117.448 93.649  1.00 74.30  ? 106 TRP   N NE1 1 
ATOM   277  C CE2 . TRP   A 1 106 ? 104.879 116.289 94.068  1.00 69.57  ? 106 TRP   N CE2 1 
ATOM   278  C CE3 . TRP   A 1 106 ? 102.654 115.483 94.533  1.00 68.65  ? 106 TRP   N CE3 1 
ATOM   279  C CZ2 . TRP   A 1 106 ? 105.441 115.062 94.397  1.00 59.25  ? 106 TRP   N CZ2 1 
ATOM   280  C CZ3 . TRP   A 1 106 ? 103.217 114.265 94.858  1.00 63.23  ? 106 TRP   N CZ3 1 
ATOM   281  C CH2 . TRP   A 1 106 ? 104.594 114.066 94.790  1.00 57.37  ? 106 TRP   N CH2 1 
ATOM   282  N N   . GLU   A 1 107 ? 99.717  119.739 91.131  1.00 77.82  ? 107 GLU   N N   1 
ATOM   283  C CA  . GLU   A 1 107 ? 98.660  120.725 90.954  1.00 77.95  ? 107 GLU   N CA  1 
ATOM   284  C C   . GLU   A 1 107 ? 97.404  120.080 90.381  1.00 84.59  ? 107 GLU   N C   1 
ATOM   285  O O   . GLU   A 1 107 ? 97.478  119.143 89.583  1.00 85.07  ? 107 GLU   N O   1 
ATOM   286  C CB  . GLU   A 1 107 ? 99.129  121.857 90.040  1.00 72.79  ? 107 GLU   N CB  1 
ATOM   287  N N   . GLU   A 1 108 ? 96.249  120.595 90.794  1.00 88.74  ? 108 GLU   N N   1 
ATOM   288  C CA  . GLU   A 1 108 ? 94.972  120.039 90.373  1.00 81.84  ? 108 GLU   N CA  1 
ATOM   289  C C   . GLU   A 1 108 ? 94.697  120.344 88.906  1.00 84.06  ? 108 GLU   N C   1 
ATOM   290  O O   . GLU   A 1 108 ? 95.223  121.302 88.337  1.00 88.26  ? 108 GLU   N O   1 
ATOM   291  C CB  . GLU   A 1 108 ? 93.840  120.596 91.234  1.00 75.84  ? 108 GLU   N CB  1 
ATOM   292  N N   . LEU   A 1 109 ? 93.860  119.509 88.296  1.00 83.89  ? 109 LEU   N N   1 
ATOM   293  C CA  . LEU   A 1 109 ? 93.483  119.705 86.903  1.00 86.92  ? 109 LEU   N CA  1 
ATOM   294  C C   . LEU   A 1 109 ? 92.627  120.956 86.760  1.00 88.36  ? 109 LEU   N C   1 
ATOM   295  O O   . LEU   A 1 109 ? 91.763  121.236 87.594  1.00 88.35  ? 109 LEU   N O   1 
ATOM   296  C CB  . LEU   A 1 109 ? 92.723  118.485 86.383  1.00 81.39  ? 109 LEU   N CB  1 
ATOM   297  C CG  . LEU   A 1 109 ? 92.532  118.355 84.873  1.00 80.84  ? 109 LEU   N CG  1 
ATOM   298  C CD1 . LEU   A 1 109 ? 93.858  118.145 84.195  1.00 83.75  ? 109 LEU   N CD1 1 
ATOM   299  C CD2 . LEU   A 1 109 ? 91.601  117.213 84.554  1.00 79.19  ? 109 LEU   N CD2 1 
ATOM   300  N N   . LEU   A 1 110 ? 92.876  121.718 85.700  1.00 86.91  ? 110 LEU   N N   1 
ATOM   301  C CA  . LEU   A 1 110 ? 92.113  122.928 85.445  1.00 88.90  ? 110 LEU   N CA  1 
ATOM   302  C C   . LEU   A 1 110 ? 91.862  123.066 83.951  1.00 95.69  ? 110 LEU   N C   1 
ATOM   303  O O   . LEU   A 1 110 ? 92.653  122.604 83.123  1.00 99.38  ? 110 LEU   N O   1 
ATOM   304  C CB  . LEU   A 1 110 ? 92.824  124.162 86.024  1.00 94.77  ? 110 LEU   N CB  1 
ATOM   305  C CG  . LEU   A 1 110 ? 94.217  124.599 85.560  1.00 100.78 ? 110 LEU   N CG  1 
ATOM   306  C CD1 . LEU   A 1 110 ? 94.164  125.434 84.296  1.00 104.09 ? 110 LEU   N CD1 1 
ATOM   307  C CD2 . LEU   A 1 110 ? 94.924  125.359 86.669  1.00 95.41  ? 110 LEU   N CD2 1 
ATOM   308  N N   . ASP   A 1 111 ? 90.750  123.712 83.620  1.00 98.23  ? 111 ASP   N N   1 
ATOM   309  C CA  . ASP   A 1 111 ? 90.272  123.816 82.249  1.00 100.10 ? 111 ASP   N CA  1 
ATOM   310  C C   . ASP   A 1 111 ? 90.515  125.219 81.716  1.00 99.22  ? 111 ASP   N C   1 
ATOM   311  O O   . ASP   A 1 111 ? 90.204  126.206 82.388  1.00 101.92 ? 111 ASP   N O   1 
ATOM   312  C CB  . ASP   A 1 111 ? 88.783  123.479 82.170  1.00 98.74  ? 111 ASP   N CB  1 
ATOM   313  N N   . GLY   A 1 112 ? 91.065  125.301 80.511  1.00 102.67 ? 112 GLY   N N   1 
ATOM   314  C CA  . GLY   A 1 112 ? 91.305  126.578 79.873  1.00 106.94 ? 112 GLY   N CA  1 
ATOM   315  C C   . GLY   A 1 112 ? 90.509  126.771 78.600  1.00 115.81 ? 112 GLY   N C   1 
ATOM   316  O O   . GLY   A 1 112 ? 90.373  125.846 77.789  1.00 120.03 ? 112 GLY   N O   1 
ATOM   317  N N   . TRP   A 1 113 ? 89.973  127.974 78.421  1.00 119.43 ? 113 TRP   N N   1 
ATOM   318  C CA  . TRP   A 1 113 ? 89.228  128.337 77.225  1.00 121.55 ? 113 TRP   N CA  1 
ATOM   319  C C   . TRP   A 1 113 ? 90.057  129.276 76.359  1.00 119.31 ? 113 TRP   N C   1 
ATOM   320  O O   . TRP   A 1 113 ? 90.710  130.191 76.867  1.00 122.01 ? 113 TRP   N O   1 
ATOM   321  C CB  . TRP   A 1 113 ? 87.902  129.002 77.592  1.00 120.83 ? 113 TRP   N CB  1 
ATOM   322  C CG  . TRP   A 1 113 ? 86.828  128.035 77.963  1.00 124.37 ? 113 TRP   N CG  1 
ATOM   323  C CD1 . TRP   A 1 113 ? 86.462  127.659 79.221  1.00 125.74 ? 113 TRP   N CD1 1 
ATOM   324  C CD2 . TRP   A 1 113 ? 85.969  127.323 77.067  1.00 127.20 ? 113 TRP   N CD2 1 
ATOM   325  N NE1 . TRP   A 1 113 ? 85.431  126.755 79.165  1.00 128.40 ? 113 TRP   N NE1 1 
ATOM   326  C CE2 . TRP   A 1 113 ? 85.110  126.532 77.852  1.00 131.12 ? 113 TRP   N CE2 1 
ATOM   327  C CE3 . TRP   A 1 113 ? 85.844  127.278 75.675  1.00 129.20 ? 113 TRP   N CE3 1 
ATOM   328  C CZ2 . TRP   A 1 113 ? 84.141  125.705 77.293  1.00 132.53 ? 113 TRP   N CZ2 1 
ATOM   329  C CZ3 . TRP   A 1 113 ? 84.881  126.456 75.122  1.00 131.84 ? 113 TRP   N CZ3 1 
ATOM   330  C CH2 . TRP   A 1 113 ? 84.043  125.681 75.929  1.00 132.07 ? 113 TRP   N CH2 1 
ATOM   331  N N   . GLY   A 1 114 ? 90.023  129.047 75.052  1.00 113.99 ? 114 GLY   N N   1 
ATOM   332  C CA  . GLY   A 1 114 ? 90.775  129.866 74.121  1.00 111.05 ? 114 GLY   N CA  1 
ATOM   333  C C   . GLY   A 1 114 ? 90.073  131.157 73.749  1.00 113.73 ? 114 GLY   N C   1 
ATOM   334  O O   . GLY   A 1 114 ? 90.195  132.164 74.444  1.00 115.35 ? 114 GLY   N O   1 
ATOM   335  N N   . MET   B 2 85  ? 130.254 133.207 129.884 1.00 96.71  ? 65  MET   R N   1 
ATOM   336  C CA  . MET   B 2 85  ? 128.834 133.469 130.079 1.00 99.17  ? 65  MET   R CA  1 
ATOM   337  C C   . MET   B 2 85  ? 128.154 133.775 128.751 1.00 100.52 ? 65  MET   R C   1 
ATOM   338  O O   . MET   B 2 85  ? 126.942 133.639 128.619 1.00 104.07 ? 65  MET   R O   1 
ATOM   339  C CB  . MET   B 2 85  ? 128.631 134.626 131.059 1.00 93.70  ? 65  MET   R CB  1 
ATOM   340  N N   . VAL   B 2 86  ? 128.943 134.188 127.762 1.00 100.66 ? 66  VAL   R N   1 
ATOM   341  C CA  . VAL   B 2 86  ? 128.380 134.499 126.451 1.00 104.82 ? 66  VAL   R CA  1 
ATOM   342  C C   . VAL   B 2 86  ? 127.954 133.219 125.742 1.00 111.59 ? 66  VAL   R C   1 
ATOM   343  O O   . VAL   B 2 86  ? 126.761 132.984 125.508 1.00 105.25 ? 66  VAL   R O   1 
ATOM   344  C CB  . VAL   B 2 86  ? 129.389 135.296 125.607 1.00 100.57 ? 66  VAL   R CB  1 
ATOM   345  N N   . THR   B 2 87  ? 128.928 132.363 125.410 1.00 117.06 ? 67  THR   R N   1 
ATOM   346  C CA  . THR   B 2 87  ? 128.629 131.134 124.679 1.00 111.38 ? 67  THR   R CA  1 
ATOM   347  C C   . THR   B 2 87  ? 127.819 130.166 125.531 1.00 107.47 ? 67  THR   R C   1 
ATOM   348  O O   . THR   B 2 87  ? 126.991 129.411 125.002 1.00 107.78 ? 67  THR   R O   1 
ATOM   349  C CB  . THR   B 2 87  ? 129.921 130.475 124.199 1.00 93.98  ? 67  THR   R CB  1 
ATOM   350  O OG1 . THR   B 2 87  ? 130.715 130.097 125.327 1.00 91.50  ? 67  THR   R OG1 1 
ATOM   351  C CG2 . THR   B 2 87  ? 130.706 131.446 123.350 1.00 89.20  ? 67  THR   R CG2 1 
ATOM   352  N N   . ALA   B 2 88  ? 128.018 130.201 126.852 1.00 99.02  ? 68  ALA   R N   1 
ATOM   353  C CA  . ALA   B 2 88  ? 127.289 129.303 127.739 1.00 98.75  ? 68  ALA   R CA  1 
ATOM   354  C C   . ALA   B 2 88  ? 125.795 129.604 127.721 1.00 102.55 ? 68  ALA   R C   1 
ATOM   355  O O   . ALA   B 2 88  ? 124.995 128.776 127.270 1.00 104.89 ? 68  ALA   R O   1 
ATOM   356  C CB  . ALA   B 2 88  ? 127.852 129.404 129.154 1.00 94.99  ? 68  ALA   R CB  1 
ATOM   357  N N   . ILE   B 2 89  ? 125.410 130.827 128.098 1.00 102.01 ? 69  ILE   R N   1 
ATOM   358  C CA  . ILE   B 2 89  ? 123.999 131.206 128.076 1.00 102.72 ? 69  ILE   R CA  1 
ATOM   359  C C   . ILE   B 2 89  ? 123.447 131.247 126.648 1.00 103.28 ? 69  ILE   R C   1 
ATOM   360  O O   . ILE   B 2 89  ? 122.242 131.067 126.458 1.00 104.81 ? 69  ILE   R O   1 
ATOM   361  C CB  . ILE   B 2 89  ? 123.800 132.540 128.827 1.00 99.27  ? 69  ILE   R CB  1 
ATOM   362  C CG1 . ILE   B 2 89  ? 124.050 132.345 130.317 1.00 87.43  ? 69  ILE   R CG1 1 
ATOM   363  C CG2 . ILE   B 2 89  ? 122.389 133.072 128.673 1.00 93.82  ? 69  ILE   R CG2 1 
ATOM   364  C CD1 . ILE   B 2 89  ? 123.823 133.589 131.123 1.00 82.16  ? 69  ILE   R CD1 1 
ATOM   365  N N   . THR   B 2 90  ? 124.303 131.403 125.632 1.00 96.34  ? 70  THR   R N   1 
ATOM   366  C CA  . THR   B 2 90  ? 123.876 131.181 124.251 1.00 96.55  ? 70  THR   R CA  1 
ATOM   367  C C   . THR   B 2 90  ? 123.396 129.746 124.031 1.00 96.67  ? 70  THR   R C   1 
ATOM   368  O O   . THR   B 2 90  ? 122.328 129.513 123.446 1.00 98.75  ? 70  THR   R O   1 
ATOM   369  C CB  . THR   B 2 90  ? 125.031 131.500 123.308 1.00 93.93  ? 70  THR   R CB  1 
ATOM   370  O OG1 . THR   B 2 90  ? 125.402 132.875 123.458 1.00 96.86  ? 70  THR   R OG1 1 
ATOM   371  C CG2 . THR   B 2 90  ? 124.638 131.222 121.876 1.00 92.53  ? 70  THR   R CG2 1 
ATOM   372  N N   . ILE   B 2 91  ? 124.171 128.769 124.506 1.00 93.50  ? 71  ILE   R N   1 
ATOM   373  C CA  . ILE   B 2 91  ? 123.787 127.368 124.354 1.00 92.06  ? 71  ILE   R CA  1 
ATOM   374  C C   . ILE   B 2 91  ? 122.534 127.040 125.162 1.00 92.25  ? 71  ILE   R C   1 
ATOM   375  O O   . ILE   B 2 91  ? 121.663 126.288 124.701 1.00 92.41  ? 71  ILE   R O   1 
ATOM   376  C CB  . ILE   B 2 91  ? 124.969 126.463 124.738 1.00 93.57  ? 71  ILE   R CB  1 
ATOM   377  C CG1 . ILE   B 2 91  ? 126.029 126.505 123.637 1.00 95.79  ? 71  ILE   R CG1 1 
ATOM   378  C CG2 . ILE   B 2 91  ? 124.490 125.054 125.011 1.00 89.34  ? 71  ILE   R CG2 1 
ATOM   379  C CD1 . ILE   B 2 91  ? 127.324 125.824 124.003 1.00 92.02  ? 71  ILE   R CD1 1 
ATOM   380  N N   . MET   B 2 92  ? 122.418 127.588 126.373 1.00 88.96  ? 72  MET   R N   1 
ATOM   381  C CA  . MET   B 2 92  ? 121.176 127.403 127.127 1.00 88.66  ? 72  MET   R CA  1 
ATOM   382  C C   . MET   B 2 92  ? 119.990 128.096 126.464 1.00 94.38  ? 72  MET   R C   1 
ATOM   383  O O   . MET   B 2 92  ? 118.853 127.618 126.580 1.00 94.03  ? 72  MET   R O   1 
ATOM   384  C CB  . MET   B 2 92  ? 121.335 127.870 128.568 1.00 88.24  ? 72  MET   R CB  1 
ATOM   385  C CG  . MET   B 2 92  ? 122.038 126.878 129.467 1.00 90.76  ? 72  MET   R CG  1 
ATOM   386  S SD  . MET   B 2 92  ? 123.823 126.965 129.430 1.00 115.32 ? 72  MET   R SD  1 
ATOM   387  C CE  . MET   B 2 92  ? 124.143 128.406 130.444 1.00 96.91  ? 72  MET   R CE  1 
ATOM   388  N N   . ALA   B 2 93  ? 120.228 129.203 125.759 1.00 94.30  ? 73  ALA   R N   1 
ATOM   389  C CA  . ALA   B 2 93  ? 119.175 129.814 124.961 1.00 90.20  ? 73  ALA   R CA  1 
ATOM   390  C C   . ALA   B 2 93  ? 118.715 128.878 123.855 1.00 87.87  ? 73  ALA   R C   1 
ATOM   391  O O   . ALA   B 2 93  ? 117.513 128.774 123.591 1.00 88.51  ? 73  ALA   R O   1 
ATOM   392  C CB  . ALA   B 2 93  ? 119.656 131.140 124.373 1.00 79.61  ? 73  ALA   R CB  1 
ATOM   393  N N   . LEU   B 2 94  ? 119.660 128.189 123.209 1.00 86.34  ? 74  LEU   R N   1 
ATOM   394  C CA  . LEU   B 2 94  ? 119.291 127.220 122.178 1.00 83.20  ? 74  LEU   R CA  1 
ATOM   395  C C   . LEU   B 2 94  ? 118.479 126.064 122.756 1.00 83.10  ? 74  LEU   R C   1 
ATOM   396  O O   . LEU   B 2 94  ? 117.498 125.627 122.139 1.00 86.30  ? 74  LEU   R O   1 
ATOM   397  C CB  . LEU   B 2 94  ? 120.528 126.686 121.464 1.00 76.94  ? 74  LEU   R CB  1 
ATOM   398  C CG  . LEU   B 2 94  ? 120.964 127.418 120.198 1.00 67.60  ? 74  LEU   R CG  1 
ATOM   399  C CD1 . LEU   B 2 94  ? 121.560 128.767 120.526 1.00 72.37  ? 74  LEU   R CD1 1 
ATOM   400  C CD2 . LEU   B 2 94  ? 121.938 126.572 119.419 1.00 65.34  ? 74  LEU   R CD2 1 
ATOM   401  N N   . TYR   B 2 95  ? 118.874 125.561 123.934 1.00 82.18  ? 75  TYR   R N   1 
ATOM   402  C CA  . TYR   B 2 95  ? 118.095 124.516 124.610 1.00 86.85  ? 75  TYR   R CA  1 
ATOM   403  C C   . TYR   B 2 95  ? 116.674 124.972 124.916 1.00 94.18  ? 75  TYR   R C   1 
ATOM   404  O O   . TYR   B 2 95  ? 115.709 124.254 124.619 1.00 99.04  ? 75  TYR   R O   1 
ATOM   405  C CB  . TYR   B 2 95  ? 118.773 124.071 125.907 1.00 88.59  ? 75  TYR   R CB  1 
ATOM   406  C CG  . TYR   B 2 95  ? 120.061 123.304 125.762 1.00 85.28  ? 75  TYR   R CG  1 
ATOM   407  C CD1 . TYR   B 2 95  ? 120.436 122.757 124.550 1.00 83.53  ? 75  TYR   R CD1 1 
ATOM   408  C CD2 . TYR   B 2 95  ? 120.904 123.127 126.847 1.00 85.03  ? 75  TYR   R CD2 1 
ATOM   409  C CE1 . TYR   B 2 95  ? 121.610 122.050 124.424 1.00 82.89  ? 75  TYR   R CE1 1 
ATOM   410  C CE2 . TYR   B 2 95  ? 122.081 122.430 126.729 1.00 83.63  ? 75  TYR   R CE2 1 
ATOM   411  C CZ  . TYR   B 2 95  ? 122.430 121.895 125.517 1.00 84.10  ? 75  TYR   R CZ  1 
ATOM   412  O OH  . TYR   B 2 95  ? 123.606 121.198 125.389 1.00 89.60  ? 75  TYR   R OH  1 
ATOM   413  N N   . SER   B 2 96  ? 116.525 126.165 125.504 1.00 89.30  ? 76  SER   R N   1 
ATOM   414  C CA  . SER   B 2 96  ? 115.197 126.651 125.873 1.00 92.69  ? 76  SER   R CA  1 
ATOM   415  C C   . SER   B 2 96  ? 114.332 126.903 124.643 1.00 99.33  ? 76  SER   R C   1 
ATOM   416  O O   . SER   B 2 96  ? 113.144 126.548 124.628 1.00 97.97  ? 76  SER   R O   1 
ATOM   417  C CB  . SER   B 2 96  ? 115.318 127.920 126.711 1.00 94.32  ? 76  SER   R CB  1 
ATOM   418  O OG  . SER   B 2 96  ? 114.056 128.302 127.227 1.00 102.11 ? 76  SER   R OG  1 
ATOM   419  N N   . ILE   B 2 97  ? 114.929 127.473 123.589 1.00 97.50  ? 77  ILE   R N   1 
ATOM   420  C CA  . ILE   B 2 97  ? 114.217 127.756 122.345 1.00 87.72  ? 77  ILE   R CA  1 
ATOM   421  C C   . ILE   B 2 97  ? 113.712 126.470 121.707 1.00 86.82  ? 77  ILE   R C   1 
ATOM   422  O O   . ILE   B 2 97  ? 112.522 126.344 121.385 1.00 88.53  ? 77  ILE   R O   1 
ATOM   423  C CB  . ILE   B 2 97  ? 115.142 128.525 121.385 1.00 80.76  ? 77  ILE   R CB  1 
ATOM   424  C CG1 . ILE   B 2 97  ? 115.265 129.985 121.808 1.00 80.18  ? 77  ILE   R CG1 1 
ATOM   425  C CG2 . ILE   B 2 97  ? 114.674 128.384 119.954 1.00 86.90  ? 77  ILE   R CG2 1 
ATOM   426  C CD1 . ILE   B 2 97  ? 116.243 130.763 120.967 1.00 82.18  ? 77  ILE   R CD1 1 
ATOM   427  N N   . VAL   B 2 98  ? 114.605 125.485 121.549 1.00 85.78  ? 78  VAL   R N   1 
ATOM   428  C CA  . VAL   B 2 98  ? 114.250 124.251 120.854 1.00 90.25  ? 78  VAL   R CA  1 
ATOM   429  C C   . VAL   B 2 98  ? 113.221 123.457 121.651 1.00 90.29  ? 78  VAL   R C   1 
ATOM   430  O O   . VAL   B 2 98  ? 112.235 122.961 121.090 1.00 89.14  ? 78  VAL   R O   1 
ATOM   431  C CB  . VAL   B 2 98  ? 115.509 123.417 120.559 1.00 85.93  ? 78  VAL   R CB  1 
ATOM   432  C CG1 . VAL   B 2 98  ? 115.125 122.093 119.937 1.00 83.26  ? 78  VAL   R CG1 1 
ATOM   433  C CG2 . VAL   B 2 98  ? 116.427 124.174 119.626 1.00 82.71  ? 78  VAL   R CG2 1 
ATOM   434  N N   . CYS   B 2 99  ? 113.415 123.350 122.975 1.00 88.51  ? 79  CYS   R N   1 
ATOM   435  C CA  . CYS   B 2 99  ? 112.490 122.566 123.788 1.00 88.67  ? 79  CYS   R CA  1 
ATOM   436  C C   . CYS   B 2 99  ? 111.108 123.207 123.839 1.00 95.83  ? 79  CYS   R C   1 
ATOM   437  O O   . CYS   B 2 99  ? 110.093 122.513 123.674 1.00 97.46  ? 79  CYS   R O   1 
ATOM   438  C CB  . CYS   B 2 99  ? 113.042 122.383 125.201 1.00 86.45  ? 79  CYS   R CB  1 
ATOM   439  S SG  . CYS   B 2 99  ? 113.040 123.866 126.214 1.00 95.17  ? 79  CYS   R SG  1 
ATOM   440  N N   . VAL   B 2 100 ? 111.048 124.536 124.017 1.00 98.44  ? 80  VAL   R N   1 
ATOM   441  C CA  . VAL   B 2 100 ? 109.765 125.229 124.095 1.00 99.68  ? 80  VAL   R CA  1 
ATOM   442  C C   . VAL   B 2 100 ? 109.016 125.141 122.769 1.00 95.82  ? 80  VAL   R C   1 
ATOM   443  O O   . VAL   B 2 100 ? 107.819 124.827 122.741 1.00 94.24  ? 80  VAL   R O   1 
ATOM   444  C CB  . VAL   B 2 100 ? 109.976 126.691 124.527 1.00 94.15  ? 80  VAL   R CB  1 
ATOM   445  N N   . VAL   B 2 101 ? 109.710 125.383 121.650 1.00 90.07  ? 81  VAL   R N   1 
ATOM   446  C CA  . VAL   B 2 101 ? 109.024 125.372 120.364 1.00 86.23  ? 81  VAL   R CA  1 
ATOM   447  C C   . VAL   B 2 101 ? 108.588 123.970 119.967 1.00 87.81  ? 81  VAL   R C   1 
ATOM   448  O O   . VAL   B 2 101 ? 107.478 123.805 119.449 1.00 90.59  ? 81  VAL   R O   1 
ATOM   449  C CB  . VAL   B 2 101 ? 109.896 125.978 119.254 1.00 84.03  ? 81  VAL   R CB  1 
ATOM   450  C CG1 . VAL   B 2 101 ? 109.250 125.730 117.909 1.00 80.59  ? 81  VAL   R CG1 1 
ATOM   451  C CG2 . VAL   B 2 101 ? 110.112 127.462 119.493 1.00 84.35  ? 81  VAL   R CG2 1 
ATOM   452  N N   . GLY   B 2 102 ? 109.412 122.950 120.219 1.00 87.78  ? 82  GLY   R N   1 
ATOM   453  C CA  . GLY   B 2 102 ? 109.011 121.587 119.932 1.00 87.30  ? 82  GLY   R CA  1 
ATOM   454  C C   . GLY   B 2 102 ? 107.830 121.116 120.755 1.00 84.58  ? 82  GLY   R C   1 
ATOM   455  O O   . GLY   B 2 102 ? 106.888 120.527 120.205 1.00 85.92  ? 82  GLY   R O   1 
ATOM   456  N N   . LEU   B 2 103 ? 107.852 121.394 122.064 1.00 81.46  ? 83  LEU   R N   1 
ATOM   457  C CA  . LEU   B 2 103 ? 106.743 120.993 122.922 1.00 83.42  ? 83  LEU   R CA  1 
ATOM   458  C C   . LEU   B 2 103 ? 105.455 121.715 122.544 1.00 84.11  ? 83  LEU   R C   1 
ATOM   459  O O   . LEU   B 2 103 ? 104.387 121.094 122.475 1.00 84.50  ? 83  LEU   R O   1 
ATOM   460  C CB  . LEU   B 2 103 ? 107.093 121.245 124.388 1.00 90.86  ? 83  LEU   R CB  1 
ATOM   461  C CG  . LEU   B 2 103 ? 108.261 120.447 124.973 1.00 93.36  ? 83  LEU   R CG  1 
ATOM   462  C CD1 . LEU   B 2 103 ? 108.876 121.185 126.151 1.00 90.21  ? 83  LEU   R CD1 1 
ATOM   463  C CD2 . LEU   B 2 103 ? 107.807 119.058 125.386 1.00 87.21  ? 83  LEU   R CD2 1 
ATOM   464  N N   . PHE   B 2 104 ? 105.537 123.021 122.263 1.00 86.14  ? 84  PHE   R N   1 
ATOM   465  C CA  . PHE   B 2 104 ? 104.333 123.770 121.914 1.00 91.00  ? 84  PHE   R CA  1 
ATOM   466  C C   . PHE   B 2 104 ? 103.757 123.319 120.578 1.00 86.76  ? 84  PHE   R C   1 
ATOM   467  O O   . PHE   B 2 104 ? 102.540 123.124 120.459 1.00 86.33  ? 84  PHE   R O   1 
ATOM   468  C CB  . PHE   B 2 104 ? 104.630 125.267 121.887 1.00 101.99 ? 84  PHE   R CB  1 
ATOM   469  C CG  . PHE   B 2 104 ? 103.404 126.124 121.754 1.00 115.64 ? 84  PHE   R CG  1 
ATOM   470  C CD1 . PHE   B 2 104 ? 102.208 125.743 122.345 1.00 114.89 ? 84  PHE   R CD1 1 
ATOM   471  C CD2 . PHE   B 2 104 ? 103.448 127.313 121.045 1.00 118.13 ? 84  PHE   R CD2 1 
ATOM   472  C CE1 . PHE   B 2 104 ? 101.079 126.527 122.225 1.00 114.21 ? 84  PHE   R CE1 1 
ATOM   473  C CE2 . PHE   B 2 104 ? 102.321 128.104 120.923 1.00 122.44 ? 84  PHE   R CE2 1 
ATOM   474  C CZ  . PHE   B 2 104 ? 101.136 127.710 121.514 1.00 118.28 ? 84  PHE   R CZ  1 
ATOM   475  N N   . GLY   B 2 105 ? 104.615 123.125 119.570 1.00 86.34  ? 85  GLY   R N   1 
ATOM   476  C CA  . GLY   B 2 105 ? 104.132 122.687 118.270 1.00 80.35  ? 85  GLY   R CA  1 
ATOM   477  C C   . GLY   B 2 105 ? 103.511 121.305 118.304 1.00 75.90  ? 85  GLY   R C   1 
ATOM   478  O O   . GLY   B 2 105 ? 102.430 121.087 117.748 1.00 75.46  ? 85  GLY   R O   1 
ATOM   479  N N   . ASN   B 2 106 ? 104.156 120.361 118.984 1.00 73.29  ? 86  ASN   R N   1 
ATOM   480  C CA  . ASN   B 2 106 ? 103.592 119.024 119.047 1.00 72.13  ? 86  ASN   R CA  1 
ATOM   481  C C   . ASN   B 2 106 ? 102.340 118.940 119.913 1.00 76.75  ? 86  ASN   R C   1 
ATOM   482  O O   . ASN   B 2 106 ? 101.419 118.183 119.569 1.00 79.86  ? 86  ASN   R O   1 
ATOM   483  C CB  . ASN   B 2 106 ? 104.661 118.043 119.522 1.00 72.96  ? 86  ASN   R CB  1 
ATOM   484  C CG  . ASN   B 2 106 ? 105.827 117.959 118.554 1.00 71.77  ? 86  ASN   R CG  1 
ATOM   485  O OD1 . ASN   B 2 106 ? 105.748 117.287 117.529 1.00 72.69  ? 86  ASN   R OD1 1 
ATOM   486  N ND2 . ASN   B 2 106 ? 106.905 118.661 118.862 1.00 74.21  ? 86  ASN   R ND2 1 
ATOM   487  N N   . PHE   B 2 107 ? 102.258 119.715 121.000 1.00 79.78  ? 87  PHE   R N   1 
ATOM   488  C CA  . PHE   B 2 107 ? 101.027 119.746 121.784 1.00 80.17  ? 87  PHE   R CA  1 
ATOM   489  C C   . PHE   B 2 107 ? 99.877  120.344 120.986 1.00 80.09  ? 87  PHE   R C   1 
ATOM   490  O O   . PHE   B 2 107 ? 98.745  119.852 121.063 1.00 82.40  ? 87  PHE   R O   1 
ATOM   491  C CB  . PHE   B 2 107 ? 101.243 120.526 123.079 1.00 84.65  ? 87  PHE   R CB  1 
ATOM   492  N N   . LEU   B 2 108 ? 100.147 121.397 120.207 1.00 78.30  ? 88  LEU   R N   1 
ATOM   493  C CA  . LEU   B 2 108 ? 99.111  121.968 119.353 1.00 74.93  ? 88  LEU   R CA  1 
ATOM   494  C C   . LEU   B 2 108 ? 98.662  120.982 118.283 1.00 77.66  ? 88  LEU   R C   1 
ATOM   495  O O   . LEU   B 2 108 ? 97.471  120.919 117.956 1.00 83.98  ? 88  LEU   R O   1 
ATOM   496  C CB  . LEU   B 2 108 ? 99.614  123.259 118.710 1.00 78.17  ? 88  LEU   R CB  1 
ATOM   497  N N   . VAL   B 2 109 ? 99.602  120.209 117.725 1.00 76.65  ? 89  VAL   R N   1 
ATOM   498  C CA  . VAL   B 2 109 ? 99.254  119.216 116.708 1.00 73.20  ? 89  VAL   R CA  1 
ATOM   499  C C   . VAL   B 2 109 ? 98.341  118.139 117.286 1.00 73.83  ? 89  VAL   R C   1 
ATOM   500  O O   . VAL   B 2 109 ? 97.322  117.785 116.678 1.00 73.96  ? 89  VAL   R O   1 
ATOM   501  C CB  . VAL   B 2 109 ? 100.529 118.609 116.093 1.00 65.76  ? 89  VAL   R CB  1 
ATOM   502  C CG1 . VAL   B 2 109 ? 100.184 117.419 115.232 1.00 62.82  ? 89  VAL   R CG1 1 
ATOM   503  C CG2 . VAL   B 2 109 ? 101.257 119.646 115.266 1.00 63.00  ? 89  VAL   R CG2 1 
ATOM   504  N N   . MET   B 2 110 ? 98.673  117.623 118.477 1.00 73.71  ? 90  MET   R N   1 
ATOM   505  C CA  . MET   B 2 110 ? 97.813  116.622 119.113 1.00 70.88  ? 90  MET   R CA  1 
ATOM   506  C C   . MET   B 2 110 ? 96.448  117.194 119.477 1.00 75.88  ? 90  MET   R C   1 
ATOM   507  O O   . MET   B 2 110 ? 95.423  116.522 119.301 1.00 80.85  ? 90  MET   R O   1 
ATOM   508  C CB  . MET   B 2 110 ? 98.472  116.062 120.365 1.00 73.42  ? 90  MET   R CB  1 
ATOM   509  C CG  . MET   B 2 110 ? 99.897  115.623 120.204 1.00 77.28  ? 90  MET   R CG  1 
ATOM   510  S SD  . MET   B 2 110 ? 100.207 114.183 121.226 1.00 91.16  ? 90  MET   R SD  1 
ATOM   511  C CE  . MET   B 2 110 ? 101.963 114.053 121.025 1.00 70.58  ? 90  MET   R CE  1 
ATOM   512  N N   . TYR   B 2 111 ? 96.423  118.428 119.991 1.00 77.32  ? 91  TYR   R N   1 
ATOM   513  C CA  . TYR   B 2 111 ? 95.170  119.095 120.335 1.00 81.50  ? 91  TYR   R CA  1 
ATOM   514  C C   . TYR   B 2 111 ? 94.254  119.255 119.129 1.00 86.62  ? 91  TYR   R C   1 
ATOM   515  O O   . TYR   B 2 111 ? 93.066  118.914 119.199 1.00 90.22  ? 91  TYR   R O   1 
ATOM   516  C CB  . TYR   B 2 111 ? 95.488  120.457 120.952 1.00 89.74  ? 91  TYR   R CB  1 
ATOM   517  C CG  . TYR   B 2 111 ? 94.297  121.318 121.298 1.00 98.77  ? 91  TYR   R CG  1 
ATOM   518  C CD1 . TYR   B 2 111 ? 93.525  121.083 122.424 1.00 97.07  ? 91  TYR   R CD1 1 
ATOM   519  C CD2 . TYR   B 2 111 ? 93.963  122.397 120.488 1.00 103.66 ? 91  TYR   R CD2 1 
ATOM   520  C CE1 . TYR   B 2 111 ? 92.442  121.896 122.719 1.00 107.30 ? 91  TYR   R CE1 1 
ATOM   521  C CE2 . TYR   B 2 111 ? 92.894  123.207 120.773 1.00 104.97 ? 91  TYR   R CE2 1 
ATOM   522  C CZ  . TYR   B 2 111 ? 92.136  122.959 121.884 1.00 109.66 ? 91  TYR   R CZ  1 
ATOM   523  O OH  . TYR   B 2 111 ? 91.068  123.785 122.145 1.00 107.65 ? 91  TYR   R OH  1 
ATOM   524  N N   . VAL   B 2 112 ? 94.785  119.747 118.007 1.00 86.95  ? 92  VAL   R N   1 
ATOM   525  C CA  . VAL   B 2 112 ? 93.921  119.958 116.851 1.00 85.80  ? 92  VAL   R CA  1 
ATOM   526  C C   . VAL   B 2 112 ? 93.525  118.634 116.211 1.00 90.12  ? 92  VAL   R C   1 
ATOM   527  O O   . VAL   B 2 112 ? 92.428  118.524 115.650 1.00 97.83  ? 92  VAL   R O   1 
ATOM   528  C CB  . VAL   B 2 112 ? 94.574  120.904 115.829 1.00 76.21  ? 92  VAL   R CB  1 
ATOM   529  C CG1 . VAL   B 2 112 ? 94.894  122.227 116.483 1.00 85.16  ? 92  VAL   R CG1 1 
ATOM   530  C CG2 . VAL   B 2 112 ? 95.807  120.280 115.222 1.00 79.71  ? 92  VAL   R CG2 1 
ATOM   531  N N   . ILE   B 2 113 ? 94.386  117.612 116.264 1.00 83.35  ? 93  ILE   R N   1 
ATOM   532  C CA  . ILE   B 2 113 ? 94.010  116.336 115.660 1.00 77.53  ? 93  ILE   R CA  1 
ATOM   533  C C   . ILE   B 2 113 ? 92.921  115.648 116.469 1.00 78.73  ? 93  ILE   R C   1 
ATOM   534  O O   . ILE   B 2 113 ? 91.991  115.065 115.904 1.00 85.94  ? 93  ILE   R O   1 
ATOM   535  C CB  . ILE   B 2 113 ? 95.234  115.425 115.475 1.00 71.90  ? 93  ILE   R CB  1 
ATOM   536  C CG1 . ILE   B 2 113 ? 96.164  115.995 114.412 1.00 68.70  ? 93  ILE   R CG1 1 
ATOM   537  C CG2 . ILE   B 2 113 ? 94.793  114.047 115.066 1.00 69.92  ? 93  ILE   R CG2 1 
ATOM   538  C CD1 . ILE   B 2 113 ? 97.452  115.248 114.289 1.00 62.86  ? 93  ILE   R CD1 1 
ATOM   539  N N   . VAL   B 2 114 ? 93.008  115.697 117.798 1.00 84.05  ? 94  VAL   R N   1 
ATOM   540  C CA  . VAL   B 2 114 ? 92.016  114.995 118.606 1.00 88.83  ? 94  VAL   R CA  1 
ATOM   541  C C   . VAL   B 2 114 ? 90.718  115.778 118.785 1.00 93.84  ? 94  VAL   R C   1 
ATOM   542  O O   . VAL   B 2 114 ? 89.647  115.164 118.891 1.00 90.23  ? 94  VAL   R O   1 
ATOM   543  C CB  . VAL   B 2 114 ? 92.585  114.632 119.990 1.00 85.53  ? 94  VAL   R CB  1 
ATOM   544  C CG1 . VAL   B 2 114 ? 91.592  113.794 120.762 1.00 83.79  ? 94  VAL   R CG1 1 
ATOM   545  C CG2 . VAL   B 2 114 ? 93.897  113.887 119.849 1.00 78.70  ? 94  VAL   R CG2 1 
ATOM   546  N N   . ARG   B 2 115 ? 90.772  117.109 118.814 1.00 98.32  ? 95  ARG   R N   1 
ATOM   547  C CA  . ARG   B 2 115 ? 89.593  117.888 119.169 1.00 103.95 ? 95  ARG   R CA  1 
ATOM   548  C C   . ARG   B 2 115 ? 88.670  118.171 117.991 1.00 110.55 ? 95  ARG   R C   1 
ATOM   549  O O   . ARG   B 2 115 ? 87.618  118.785 118.193 1.00 118.69 ? 95  ARG   R O   1 
ATOM   550  C CB  . ARG   B 2 115 ? 90.014  119.212 119.815 1.00 100.54 ? 95  ARG   R CB  1 
ATOM   551  N N   . TYR   B 2 116 ? 89.022  117.748 116.781 1.00 104.90 ? 96  TYR   R N   1 
ATOM   552  C CA  . TYR   B 2 116 ? 88.215  118.008 115.597 1.00 108.73 ? 96  TYR   R CA  1 
ATOM   553  C C   . TYR   B 2 116 ? 87.790  116.693 114.955 1.00 113.63 ? 96  TYR   R C   1 
ATOM   554  O O   . TYR   B 2 116 ? 88.569  115.737 114.895 1.00 106.83 ? 96  TYR   R O   1 
ATOM   555  C CB  . TYR   B 2 116 ? 88.980  118.869 114.585 1.00 97.65  ? 96  TYR   R CB  1 
ATOM   556  N N   . THR   B 2 117 ? 86.540  116.645 114.489 1.00 118.71 ? 97  THR   R N   1 
ATOM   557  C CA  . THR   B 2 117 ? 86.034  115.447 113.829 1.00 116.86 ? 97  THR   R CA  1 
ATOM   558  C C   . THR   B 2 117 ? 86.562  115.322 112.404 1.00 114.17 ? 97  THR   R C   1 
ATOM   559  O O   . THR   B 2 117 ? 86.768  114.208 111.911 1.00 112.31 ? 97  THR   R O   1 
ATOM   560  C CB  . THR   B 2 117 ? 84.505  115.451 113.827 1.00 109.52 ? 97  THR   R CB  1 
ATOM   561  N N   . LYS   B 2 118 ? 86.786  116.449 111.728 1.00 109.72 ? 98  LYS   R N   1 
ATOM   562  C CA  . LYS   B 2 118 ? 87.227  116.419 110.340 1.00 102.94 ? 98  LYS   R CA  1 
ATOM   563  C C   . LYS   B 2 118 ? 88.694  116.039 110.184 1.00 106.38 ? 98  LYS   R C   1 
ATOM   564  O O   . LYS   B 2 118 ? 89.126  115.780 109.056 1.00 105.59 ? 98  LYS   R O   1 
ATOM   565  C CB  . LYS   B 2 118 ? 86.976  117.777 109.686 1.00 92.99  ? 98  LYS   R CB  1 
ATOM   566  N N   . MET   B 2 119 ? 89.467  116.006 111.268 1.00 106.23 ? 99  MET   R N   1 
ATOM   567  C CA  . MET   B 2 119 ? 90.871  115.624 111.209 1.00 99.97  ? 99  MET   R CA  1 
ATOM   568  C C   . MET   B 2 119 ? 91.113  114.134 111.404 1.00 96.26  ? 99  MET   R C   1 
ATOM   569  O O   . MET   B 2 119 ? 92.249  113.684 111.223 1.00 92.66  ? 99  MET   R O   1 
ATOM   570  C CB  . MET   B 2 119 ? 91.674  116.397 112.256 1.00 88.49  ? 99  MET   R CB  1 
ATOM   571  C CG  . MET   B 2 119 ? 91.787  117.879 112.000 1.00 83.48  ? 99  MET   R CG  1 
ATOM   572  S SD  . MET   B 2 119 ? 92.715  118.179 110.491 1.00 87.76  ? 99  MET   R SD  1 
ATOM   573  C CE  . MET   B 2 119 ? 92.512  119.938 110.310 1.00 95.10  ? 99  MET   R CE  1 
ATOM   574  N N   . LYS   B 2 120 ? 90.091  113.355 111.745 1.00 93.74  ? 100 LYS   R N   1 
ATOM   575  C CA  . LYS   B 2 120 ? 90.256  111.925 111.978 1.00 92.07  ? 100 LYS   R CA  1 
ATOM   576  C C   . LYS   B 2 120 ? 90.325  111.217 110.630 1.00 94.61  ? 100 LYS   R C   1 
ATOM   577  O O   . LYS   B 2 120 ? 89.293  110.921 110.020 1.00 98.47  ? 100 LYS   R O   1 
ATOM   578  C CB  . LYS   B 2 120 ? 89.118  111.383 112.837 1.00 92.31  ? 100 LYS   R CB  1 
ATOM   579  N N   . THR   B 2 121 ? 91.540  110.938 110.171 1.00 88.58  ? 101 THR   R N   1 
ATOM   580  C CA  . THR   B 2 121 ? 91.783  110.376 108.853 1.00 84.40  ? 101 THR   R CA  1 
ATOM   581  C C   . THR   B 2 121 ? 92.835  109.287 109.006 1.00 82.96  ? 101 THR   R C   1 
ATOM   582  O O   . THR   B 2 121 ? 93.504  109.191 110.036 1.00 85.28  ? 101 THR   R O   1 
ATOM   583  C CB  . THR   B 2 121 ? 92.230  111.474 107.874 1.00 85.18  ? 101 THR   R CB  1 
ATOM   584  O OG1 . THR   B 2 121 ? 91.382  112.615 108.034 1.00 92.72  ? 101 THR   R OG1 1 
ATOM   585  C CG2 . THR   B 2 121 ? 92.126  111.023 106.423 1.00 84.77  ? 101 THR   R CG2 1 
ATOM   586  N N   . ALA   B 2 122 ? 92.977  108.443 107.984 1.00 79.56  ? 102 ALA   R N   1 
ATOM   587  C CA  . ALA   B 2 122 ? 93.983  107.391 108.032 1.00 77.45  ? 102 ALA   R CA  1 
ATOM   588  C C   . ALA   B 2 122 ? 95.407  107.929 108.019 1.00 74.14  ? 102 ALA   R C   1 
ATOM   589  O O   . ALA   B 2 122 ? 96.321  107.216 108.437 1.00 70.34  ? 102 ALA   R O   1 
ATOM   590  C CB  . ALA   B 2 122 ? 93.796  106.430 106.865 1.00 82.29  ? 102 ALA   R CB  1 
ATOM   591  N N   . THR   B 2 123 ? 95.624  109.154 107.544 1.00 74.89  ? 103 THR   R N   1 
ATOM   592  C CA  . THR   B 2 123 ? 96.959  109.736 107.543 1.00 70.97  ? 103 THR   R CA  1 
ATOM   593  C C   . THR   B 2 123 ? 97.061  110.933 108.478 1.00 71.50  ? 103 THR   R C   1 
ATOM   594  O O   . THR   B 2 123 ? 97.864  111.839 108.245 1.00 74.26  ? 103 THR   R O   1 
ATOM   595  C CB  . THR   B 2 123 ? 97.362  110.148 106.132 1.00 73.59  ? 103 THR   R CB  1 
ATOM   596  O OG1 . THR   B 2 123 ? 98.717  110.609 106.139 1.00 65.35  ? 103 THR   R OG1 1 
ATOM   597  C CG2 . THR   B 2 123 ? 96.450  111.244 105.623 1.00 78.08  ? 103 THR   R CG2 1 
ATOM   598  N N   . ASN   B 2 124 ? 96.258  110.944 109.538 1.00 69.90  ? 104 ASN   R N   1 
ATOM   599  C CA  . ASN   B 2 124 ? 96.424  111.900 110.624 1.00 63.96  ? 104 ASN   R CA  1 
ATOM   600  C C   . ASN   B 2 124 ? 96.624  111.144 111.925 1.00 66.95  ? 104 ASN   R C   1 
ATOM   601  O O   . ASN   B 2 124 ? 96.930  111.740 112.959 1.00 73.49  ? 104 ASN   R O   1 
ATOM   602  C CB  . ASN   B 2 124 ? 95.228  112.843 110.737 1.00 66.03  ? 104 ASN   R CB  1 
ATOM   603  C CG  . ASN   B 2 124 ? 95.084  113.748 109.539 1.00 73.10  ? 104 ASN   R CG  1 
ATOM   604  O OD1 . ASN   B 2 124 ? 94.109  113.667 108.800 1.00 74.46  ? 104 ASN   R OD1 1 
ATOM   605  N ND2 . ASN   B 2 124 ? 96.057  114.623 109.342 1.00 76.52  ? 104 ASN   R ND2 1 
ATOM   606  N N   . ILE   B 2 125 ? 96.418  109.831 111.889 1.00 65.14  ? 105 ILE   R N   1 
ATOM   607  C CA  . ILE   B 2 125 ? 96.855  108.977 112.984 1.00 63.70  ? 105 ILE   R CA  1 
ATOM   608  C C   . ILE   B 2 125 ? 98.369  108.810 112.945 1.00 65.21  ? 105 ILE   R C   1 
ATOM   609  O O   . ILE   B 2 125 ? 99.044  108.840 113.984 1.00 69.13  ? 105 ILE   R O   1 
ATOM   610  C CB  . ILE   B 2 125 ? 96.131  107.623 112.907 1.00 64.07  ? 105 ILE   R CB  1 
ATOM   611  C CG1 . ILE   B 2 125 ? 94.623  107.822 113.022 1.00 59.11  ? 105 ILE   R CG1 1 
ATOM   612  C CG2 . ILE   B 2 125 ? 96.623  106.700 113.991 1.00 71.17  ? 105 ILE   R CG2 1 
ATOM   613  C CD1 . ILE   B 2 125 ? 94.219  108.684 114.172 1.00 57.06  ? 105 ILE   R CD1 1 
ATOM   614  N N   . TYR   B 2 126 ? 98.921  108.647 111.742 1.00 60.73  ? 106 TYR   R N   1 
ATOM   615  C CA  . TYR   B 2 126 ? 100.362 108.517 111.586 1.00 57.32  ? 106 TYR   R CA  1 
ATOM   616  C C   . TYR   B 2 126 ? 101.073 109.798 111.991 1.00 62.03  ? 106 TYR   R C   1 
ATOM   617  O O   . TYR   B 2 126 ? 102.127 109.759 112.632 1.00 70.71  ? 106 TYR   R O   1 
ATOM   618  C CB  . TYR   B 2 126 ? 100.697 108.151 110.142 1.00 59.59  ? 106 TYR   R CB  1 
ATOM   619  C CG  . TYR   B 2 126 ? 100.140 106.824 109.666 1.00 67.72  ? 106 TYR   R CG  1 
ATOM   620  C CD1 . TYR   B 2 126 ? 99.830  105.809 110.554 1.00 68.40  ? 106 TYR   R CD1 1 
ATOM   621  C CD2 . TYR   B 2 126 ? 99.899  106.602 108.324 1.00 70.76  ? 106 TYR   R CD2 1 
ATOM   622  C CE1 . TYR   B 2 126 ? 99.311  104.611 110.112 1.00 69.91  ? 106 TYR   R CE1 1 
ATOM   623  C CE2 . TYR   B 2 126 ? 99.381  105.410 107.878 1.00 65.27  ? 106 TYR   R CE2 1 
ATOM   624  C CZ  . TYR   B 2 126 ? 99.090  104.420 108.772 1.00 65.06  ? 106 TYR   R CZ  1 
ATOM   625  O OH  . TYR   B 2 126 ? 98.573  103.232 108.319 1.00 65.77  ? 106 TYR   R OH  1 
ATOM   626  N N   . ILE   B 2 127 ? 100.501 110.950 111.631 1.00 60.37  ? 107 ILE   R N   1 
ATOM   627  C CA  . ILE   B 2 127 ? 101.091 112.233 112.006 1.00 54.52  ? 107 ILE   R CA  1 
ATOM   628  C C   . ILE   B 2 127 ? 101.024 112.429 113.512 1.00 56.50  ? 107 ILE   R C   1 
ATOM   629  O O   . ILE   B 2 127 ? 101.928 113.016 114.116 1.00 65.56  ? 107 ILE   R O   1 
ATOM   630  C CB  . ILE   B 2 127 ? 100.392 113.380 111.261 1.00 51.30  ? 107 ILE   R CB  1 
ATOM   631  C CG1 . ILE   B 2 127 ? 100.784 113.379 109.792 1.00 56.34  ? 107 ILE   R CG1 1 
ATOM   632  C CG2 . ILE   B 2 127 ? 100.759 114.701 111.876 1.00 53.54  ? 107 ILE   R CG2 1 
ATOM   633  C CD1 . ILE   B 2 127 ? 100.054 114.411 108.985 1.00 57.78  ? 107 ILE   R CD1 1 
ATOM   634  N N   . PHE   B 2 128 ? 99.946  111.955 114.137 1.00 52.43  ? 108 PHE   R N   1 
ATOM   635  C CA  . PHE   B 2 128 ? 99.817  112.025 115.589 1.00 50.64  ? 108 PHE   R CA  1 
ATOM   636  C C   . PHE   B 2 128 ? 100.903 111.200 116.266 1.00 57.99  ? 108 PHE   R C   1 
ATOM   637  O O   . PHE   B 2 128 ? 101.521 111.646 117.236 1.00 64.82  ? 108 PHE   R O   1 
ATOM   638  C CB  . PHE   B 2 128 ? 98.416  111.551 115.985 1.00 51.17  ? 108 PHE   R CB  1 
ATOM   639  C CG  . PHE   B 2 128 ? 98.142  111.551 117.463 1.00 53.35  ? 108 PHE   R CG  1 
ATOM   640  C CD1 . PHE   B 2 128 ? 97.660  112.688 118.079 1.00 60.06  ? 108 PHE   R CD1 1 
ATOM   641  C CD2 . PHE   B 2 128 ? 98.322  110.412 118.228 1.00 52.51  ? 108 PHE   R CD2 1 
ATOM   642  C CE1 . PHE   B 2 128 ? 97.386  112.700 119.425 1.00 59.33  ? 108 PHE   R CE1 1 
ATOM   643  C CE2 . PHE   B 2 128 ? 98.052  110.422 119.574 1.00 60.63  ? 108 PHE   R CE2 1 
ATOM   644  C CZ  . PHE   B 2 128 ? 97.583  111.568 120.173 1.00 64.32  ? 108 PHE   R CZ  1 
ATOM   645  N N   . ASN   B 2 129 ? 101.169 110.001 115.744 1.00 58.68  ? 109 ASN   R N   1 
ATOM   646  C CA  . ASN   B 2 129 ? 102.255 109.182 116.283 1.00 59.04  ? 109 ASN   R CA  1 
ATOM   647  C C   . ASN   B 2 129 ? 103.616 109.842 116.065 1.00 58.53  ? 109 ASN   R C   1 
ATOM   648  O O   . ASN   B 2 129 ? 104.501 109.768 116.929 1.00 62.28  ? 109 ASN   R O   1 
ATOM   649  C CB  . ASN   B 2 129 ? 102.210 107.795 115.646 1.00 60.97  ? 109 ASN   R CB  1 
ATOM   650  C CG  . ASN   B 2 129 ? 103.066 106.785 116.373 1.00 68.87  ? 109 ASN   R CG  1 
ATOM   651  O OD1 . ASN   B 2 129 ? 104.280 106.937 116.484 1.00 72.83  ? 109 ASN   R OD1 1 
ATOM   652  N ND2 . ASN   B 2 129 ? 102.431 105.738 116.876 1.00 77.81  ? 109 ASN   R ND2 1 
ATOM   653  N N   . LEU   B 2 130 ? 103.799 110.489 114.912 1.00 56.91  ? 110 LEU   R N   1 
ATOM   654  C CA  . LEU   B 2 130 ? 105.055 111.172 114.610 1.00 57.56  ? 110 LEU   R CA  1 
ATOM   655  C C   . LEU   B 2 130 ? 105.304 112.325 115.575 1.00 60.56  ? 110 LEU   R C   1 
ATOM   656  O O   . LEU   B 2 130 ? 106.405 112.474 116.121 1.00 63.73  ? 110 LEU   R O   1 
ATOM   657  C CB  . LEU   B 2 130 ? 105.020 111.675 113.170 1.00 57.38  ? 110 LEU   R CB  1 
ATOM   658  C CG  . LEU   B 2 130 ? 106.340 111.895 112.453 1.00 61.26  ? 110 LEU   R CG  1 
ATOM   659  C CD1 . LEU   B 2 130 ? 106.933 110.559 112.099 1.00 65.03  ? 110 LEU   R CD1 1 
ATOM   660  C CD2 . LEU   B 2 130 ? 106.121 112.725 111.210 1.00 62.74  ? 110 LEU   R CD2 1 
ATOM   661  N N   . ALA   B 2 131 ? 104.272 113.125 115.839 1.00 59.05  ? 111 ALA   R N   1 
ATOM   662  C CA  . ALA   B 2 131 ? 104.363 114.249 116.772 1.00 55.65  ? 111 ALA   R CA  1 
ATOM   663  C C   . ALA   B 2 131 ? 104.213 113.805 118.218 1.00 61.46  ? 111 ALA   R C   1 
ATOM   664  O O   . ALA   B 2 131 ? 104.255 114.625 119.136 1.00 70.63  ? 111 ALA   R O   1 
ATOM   665  C CB  . ALA   B 2 131 ? 103.321 115.303 116.421 1.00 53.51  ? 111 ALA   R CB  1 
ATOM   666  N N   . LEU   B 2 132 ? 104.016 112.509 118.442 1.00 60.28  ? 112 LEU   R N   1 
ATOM   667  C CA  . LEU   B 2 132 ? 104.144 111.918 119.764 1.00 65.27  ? 112 LEU   R CA  1 
ATOM   668  C C   . LEU   B 2 132 ? 105.605 111.585 120.030 1.00 68.14  ? 112 LEU   R C   1 
ATOM   669  O O   . LEU   B 2 132 ? 106.149 111.930 121.086 1.00 67.42  ? 112 LEU   R O   1 
ATOM   670  C CB  . LEU   B 2 132 ? 103.280 110.663 119.857 1.00 64.39  ? 112 LEU   R CB  1 
ATOM   671  C CG  . LEU   B 2 132 ? 103.208 109.909 121.178 1.00 71.55  ? 112 LEU   R CG  1 
ATOM   672  C CD1 . LEU   B 2 132 ? 102.586 110.789 122.240 1.00 75.61  ? 112 LEU   R CD1 1 
ATOM   673  C CD2 . LEU   B 2 132 ? 102.425 108.623 121.015 1.00 67.24  ? 112 LEU   R CD2 1 
ATOM   674  N N   . ALA   B 2 133 ? 106.247 110.929 119.060 1.00 69.48  ? 113 ALA   R N   1 
ATOM   675  C CA  . ALA   B 2 133 ? 107.662 110.587 119.203 1.00 65.36  ? 113 ALA   R CA  1 
ATOM   676  C C   . ALA   B 2 133 ? 108.538 111.836 119.256 1.00 65.04  ? 113 ALA   R C   1 
ATOM   677  O O   . ALA   B 2 133 ? 109.530 111.877 119.995 1.00 64.30  ? 113 ALA   R O   1 
ATOM   678  C CB  . ALA   B 2 133 ? 108.102 109.669 118.064 1.00 57.94  ? 113 ALA   R CB  1 
ATOM   679  N N   . ASP   B 2 134 ? 108.183 112.869 118.480 1.00 65.41  ? 114 ASP   R N   1 
ATOM   680  C CA  . ASP   B 2 134 ? 108.953 114.112 118.499 1.00 64.54  ? 114 ASP   R CA  1 
ATOM   681  C C   . ASP   B 2 134 ? 108.861 114.818 119.848 1.00 64.82  ? 114 ASP   R C   1 
ATOM   682  O O   . ASP   B 2 134 ? 109.861 115.340 120.352 1.00 70.98  ? 114 ASP   R O   1 
ATOM   683  C CB  . ASP   B 2 134 ? 108.483 115.036 117.380 1.00 72.04  ? 114 ASP   R CB  1 
ATOM   684  C CG  . ASP   B 2 134 ? 108.989 114.607 116.018 1.00 79.97  ? 114 ASP   R CG  1 
ATOM   685  O OD1 . ASP   B 2 134 ? 109.795 113.657 115.957 1.00 76.09  ? 114 ASP   R OD1 1 
ATOM   686  O OD2 . ASP   B 2 134 ? 108.584 115.221 115.008 1.00 81.50  ? 114 ASP   R OD2 1 
ATOM   687  N N   . ALA   B 2 135 ? 107.671 114.852 120.450 1.00 62.49  ? 115 ALA   R N   1 
ATOM   688  C CA  . ALA   B 2 135 ? 107.543 115.436 121.782 1.00 64.56  ? 115 ALA   R CA  1 
ATOM   689  C C   . ALA   B 2 135 ? 108.264 114.602 122.832 1.00 74.47  ? 115 ALA   R C   1 
ATOM   690  O O   . ALA   B 2 135 ? 108.817 115.158 123.789 1.00 75.74  ? 115 ALA   R O   1 
ATOM   691  C CB  . ALA   B 2 135 ? 106.071 115.595 122.150 1.00 61.04  ? 115 ALA   R CB  1 
ATOM   692  N N   . LEU   B 2 136 ? 108.267 113.272 122.669 1.00 79.39  ? 116 LEU   R N   1 
ATOM   693  C CA  . LEU   B 2 136 ? 109.029 112.403 123.566 1.00 74.64  ? 116 LEU   R CA  1 
ATOM   694  C C   . LEU   B 2 136 ? 110.521 112.698 123.496 1.00 68.28  ? 116 LEU   R C   1 
ATOM   695  O O   . LEU   B 2 136 ? 111.207 112.698 124.522 1.00 63.19  ? 116 LEU   R O   1 
ATOM   696  C CB  . LEU   B 2 136 ? 108.770 110.937 123.222 1.00 71.01  ? 116 LEU   R CB  1 
ATOM   697  C CG  . LEU   B 2 136 ? 107.764 110.174 124.080 1.00 72.21  ? 116 LEU   R CG  1 
ATOM   698  C CD1 . LEU   B 2 136 ? 106.360 110.727 123.889 1.00 69.57  ? 116 LEU   R CD1 1 
ATOM   699  C CD2 . LEU   B 2 136 ? 107.815 108.700 123.737 1.00 79.23  ? 116 LEU   R CD2 1 
ATOM   700  N N   . ALA   B 2 137 ? 111.042 112.936 122.291 1.00 67.04  ? 117 ALA   R N   1 
ATOM   701  C CA  . ALA   B 2 137 ? 112.437 113.345 122.161 1.00 63.35  ? 117 ALA   R CA  1 
ATOM   702  C C   . ALA   B 2 137 ? 112.683 114.709 122.792 1.00 68.68  ? 117 ALA   R C   1 
ATOM   703  O O   . ALA   B 2 137 ? 113.660 114.895 123.524 1.00 68.85  ? 117 ALA   R O   1 
ATOM   704  C CB  . ALA   B 2 137 ? 112.843 113.380 120.692 1.00 59.05  ? 117 ALA   R CB  1 
ATOM   705  N N   . THR   B 2 138 ? 111.807 115.678 122.515 1.00 73.39  ? 118 THR   R N   1 
ATOM   706  C CA  . THR   B 2 138 ? 112.019 117.048 122.969 1.00 71.43  ? 118 THR   R CA  1 
ATOM   707  C C   . THR   B 2 138 ? 111.908 117.194 124.480 1.00 68.61  ? 118 THR   R C   1 
ATOM   708  O O   . THR   B 2 138 ? 112.495 118.121 125.042 1.00 72.48  ? 118 THR   R O   1 
ATOM   709  C CB  . THR   B 2 138 ? 111.020 117.983 122.288 1.00 72.00  ? 118 THR   R CB  1 
ATOM   710  O OG1 . THR   B 2 138 ? 111.055 117.768 120.874 1.00 80.17  ? 118 THR   R OG1 1 
ATOM   711  C CG2 . THR   B 2 138 ? 111.362 119.432 122.570 1.00 71.12  ? 118 THR   R CG2 1 
ATOM   712  N N   . SER   B 2 139 ? 111.180 116.304 125.155 1.00 65.38  ? 119 SER   R N   1 
ATOM   713  C CA  . SER   B 2 139 ? 111.016 116.444 126.598 1.00 68.58  ? 119 SER   R CA  1 
ATOM   714  C C   . SER   B 2 139 ? 112.286 116.155 127.392 1.00 75.19  ? 119 SER   R C   1 
ATOM   715  O O   . SER   B 2 139 ? 112.328 116.482 128.581 1.00 83.85  ? 119 SER   R O   1 
ATOM   716  C CB  . SER   B 2 139 ? 109.898 115.530 127.087 1.00 76.33  ? 119 SER   R CB  1 
ATOM   717  O OG  . SER   B 2 139 ? 110.314 114.177 127.090 1.00 79.75  ? 119 SER   R OG  1 
ATOM   718  N N   . THR   B 2 140 ? 113.304 115.543 126.789 1.00 72.43  ? 120 THR   R N   1 
ATOM   719  C CA  . THR   B 2 140 ? 114.557 115.258 127.479 1.00 68.79  ? 120 THR   R CA  1 
ATOM   720  C C   . THR   B 2 140 ? 115.581 116.380 127.367 1.00 68.78  ? 120 THR   R C   1 
ATOM   721  O O   . THR   B 2 140 ? 116.628 116.303 128.012 1.00 70.02  ? 120 THR   R O   1 
ATOM   722  C CB  . THR   B 2 140 ? 115.181 113.975 126.934 1.00 64.98  ? 120 THR   R CB  1 
ATOM   723  O OG1 . THR   B 2 140 ? 115.800 114.247 125.674 1.00 62.71  ? 120 THR   R OG1 1 
ATOM   724  C CG2 . THR   B 2 140 ? 114.124 112.920 126.739 1.00 70.71  ? 120 THR   R CG2 1 
ATOM   725  N N   . LEU   B 2 141 ? 115.317 117.399 126.555 1.00 68.30  ? 121 LEU   R N   1 
ATOM   726  C CA  . LEU   B 2 141 ? 116.270 118.495 126.401 1.00 67.29  ? 121 LEU   R CA  1 
ATOM   727  C C   . LEU   B 2 141 ? 116.516 119.314 127.667 1.00 75.07  ? 121 LEU   R C   1 
ATOM   728  O O   . LEU   B 2 141 ? 117.673 119.719 127.874 1.00 83.72  ? 121 LEU   R O   1 
ATOM   729  C CB  . LEU   B 2 141 ? 115.836 119.397 125.242 1.00 64.81  ? 121 LEU   R CB  1 
ATOM   730  C CG  . LEU   B 2 141 ? 116.108 118.753 123.878 1.00 66.93  ? 121 LEU   R CG  1 
ATOM   731  C CD1 . LEU   B 2 141 ? 115.969 119.745 122.729 1.00 72.46  ? 121 LEU   R CD1 1 
ATOM   732  C CD2 . LEU   B 2 141 ? 117.470 118.095 123.852 1.00 64.03  ? 121 LEU   R CD2 1 
ATOM   733  N N   . PRO   B 2 142 ? 115.517 119.655 128.495 1.00 72.90  ? 122 PRO   R N   1 
ATOM   734  C CA  . PRO   B 2 142 ? 115.828 120.349 129.762 1.00 75.76  ? 122 PRO   R CA  1 
ATOM   735  C C   . PRO   B 2 142 ? 116.756 119.590 130.700 1.00 74.32  ? 122 PRO   R C   1 
ATOM   736  O O   . PRO   B 2 142 ? 117.522 120.218 131.443 1.00 72.40  ? 122 PRO   R O   1 
ATOM   737  C CB  . PRO   B 2 142 ? 114.445 120.548 130.391 1.00 74.13  ? 122 PRO   R CB  1 
ATOM   738  C CG  . PRO   B 2 142 ? 113.538 120.653 129.244 1.00 70.93  ? 122 PRO   R CG  1 
ATOM   739  C CD  . PRO   B 2 142 ? 114.086 119.778 128.160 1.00 70.20  ? 122 PRO   R CD  1 
ATOM   740  N N   . PHE   B 2 143 ? 116.727 118.259 130.688 1.00 75.21  ? 123 PHE   R N   1 
ATOM   741  C CA  . PHE   B 2 143 ? 117.643 117.511 131.540 1.00 75.05  ? 123 PHE   R CA  1 
ATOM   742  C C   . PHE   B 2 143 ? 119.080 117.629 131.049 1.00 77.54  ? 123 PHE   R C   1 
ATOM   743  O O   . PHE   B 2 143 ? 120.002 117.770 131.859 1.00 83.56  ? 123 PHE   R O   1 
ATOM   744  C CB  . PHE   B 2 143 ? 117.192 116.059 131.629 1.00 72.70  ? 123 PHE   R CB  1 
ATOM   745  C CG  . PHE   B 2 143 ? 115.781 115.916 132.087 1.00 74.26  ? 123 PHE   R CG  1 
ATOM   746  C CD1 . PHE   B 2 143 ? 115.421 116.300 133.362 1.00 73.52  ? 123 PHE   R CD1 1 
ATOM   747  C CD2 . PHE   B 2 143 ? 114.809 115.435 131.238 1.00 77.56  ? 123 PHE   R CD2 1 
ATOM   748  C CE1 . PHE   B 2 143 ? 114.121 116.188 133.790 1.00 76.78  ? 123 PHE   R CE1 1 
ATOM   749  C CE2 . PHE   B 2 143 ? 113.506 115.320 131.660 1.00 81.22  ? 123 PHE   R CE2 1 
ATOM   750  C CZ  . PHE   B 2 143 ? 113.162 115.697 132.940 1.00 81.00  ? 123 PHE   R CZ  1 
ATOM   751  N N   . GLN   B 2 144 ? 119.292 117.603 129.730 1.00 72.03  ? 124 GLN   R N   1 
ATOM   752  C CA  . GLN   B 2 144 ? 120.616 117.910 129.195 1.00 75.61  ? 124 GLN   R CA  1 
ATOM   753  C C   . GLN   B 2 144 ? 121.003 119.349 129.499 1.00 80.93  ? 124 GLN   R C   1 
ATOM   754  O O   . GLN   B 2 144 ? 122.185 119.654 129.698 1.00 80.37  ? 124 GLN   R O   1 
ATOM   755  C CB  . GLN   B 2 144 ? 120.654 117.680 127.690 1.00 68.58  ? 124 GLN   R CB  1 
ATOM   756  C CG  . GLN   B 2 144 ? 120.446 116.266 127.256 1.00 70.30  ? 124 GLN   R CG  1 
ATOM   757  C CD  . GLN   B 2 144 ? 120.563 116.135 125.763 1.00 76.22  ? 124 GLN   R CD  1 
ATOM   758  O OE1 . GLN   B 2 144 ? 120.800 117.116 125.067 1.00 80.26  ? 124 GLN   R OE1 1 
ATOM   759  N NE2 . GLN   B 2 144 ? 120.387 114.925 125.256 1.00 76.50  ? 124 GLN   R NE2 1 
ATOM   760  N N   . SER   B 2 145 ? 120.012 120.247 129.523 1.00 80.48  ? 125 SER   R N   1 
ATOM   761  C CA  . SER   B 2 145 ? 120.248 121.643 129.877 1.00 79.01  ? 125 SER   R CA  1 
ATOM   762  C C   . SER   B 2 145 ? 120.792 121.766 131.293 1.00 80.32  ? 125 SER   R C   1 
ATOM   763  O O   . SER   B 2 145 ? 121.735 122.519 131.544 1.00 85.26  ? 125 SER   R O   1 
ATOM   764  C CB  . SER   B 2 145 ? 118.950 122.436 129.728 1.00 73.46  ? 125 SER   R CB  1 
ATOM   765  O OG  . SER   B 2 145 ? 118.977 123.616 130.507 1.00 75.75  ? 125 SER   R OG  1 
ATOM   766  N N   . VAL   B 2 146 ? 120.210 121.025 132.232 1.00 75.20  ? 126 VAL   R N   1 
ATOM   767  C CA  . VAL   B 2 146 ? 120.720 121.052 133.599 1.00 73.91  ? 126 VAL   R CA  1 
ATOM   768  C C   . VAL   B 2 146 ? 122.066 120.347 133.690 1.00 76.01  ? 126 VAL   R C   1 
ATOM   769  O O   . VAL   B 2 146 ? 122.945 120.762 134.452 1.00 77.95  ? 126 VAL   R O   1 
ATOM   770  C CB  . VAL   B 2 146 ? 119.700 120.446 134.573 1.00 77.23  ? 126 VAL   R CB  1 
ATOM   771  C CG1 . VAL   B 2 146 ? 120.296 120.387 135.962 1.00 85.99  ? 126 VAL   R CG1 1 
ATOM   772  C CG2 . VAL   B 2 146 ? 118.439 121.278 134.585 1.00 73.60  ? 126 VAL   R CG2 1 
ATOM   773  N N   . ASN   B 2 147 ? 122.249 119.267 132.932 1.00 75.32  ? 127 ASN   R N   1 
ATOM   774  C CA  . ASN   B 2 147 ? 123.492 118.509 133.006 1.00 80.02  ? 127 ASN   R CA  1 
ATOM   775  C C   . ASN   B 2 147 ? 124.675 119.250 132.401 1.00 82.56  ? 127 ASN   R C   1 
ATOM   776  O O   . ASN   B 2 147 ? 125.818 118.955 132.758 1.00 84.12  ? 127 ASN   R O   1 
ATOM   777  C CB  . ASN   B 2 147 ? 123.334 117.162 132.306 1.00 78.44  ? 127 ASN   R CB  1 
ATOM   778  C CG  . ASN   B 2 147 ? 124.447 116.196 132.643 1.00 81.02  ? 127 ASN   R CG  1 
ATOM   779  O OD1 . ASN   B 2 147 ? 125.211 116.412 133.580 1.00 80.09  ? 127 ASN   R OD1 1 
ATOM   780  N ND2 . ASN   B 2 147 ? 124.543 115.119 131.878 1.00 78.02  ? 127 ASN   R ND2 1 
ATOM   781  N N   . TYR   B 2 148 ? 124.441 120.180 131.475 1.00 83.94  ? 128 TYR   R N   1 
ATOM   782  C CA  . TYR   B 2 148 ? 125.565 120.879 130.860 1.00 80.20  ? 128 TYR   R CA  1 
ATOM   783  C C   . TYR   B 2 148 ? 126.231 121.834 131.842 1.00 79.06  ? 128 TYR   R C   1 
ATOM   784  O O   . TYR   B 2 148 ? 127.461 121.878 131.934 1.00 83.13  ? 128 TYR   R O   1 
ATOM   785  C CB  . TYR   B 2 148 ? 125.115 121.629 129.610 1.00 75.76  ? 128 TYR   R CB  1 
ATOM   786  C CG  . TYR   B 2 148 ? 126.093 122.690 129.172 1.00 79.38  ? 128 TYR   R CG  1 
ATOM   787  C CD1 . TYR   B 2 148 ? 127.296 122.342 128.579 1.00 84.24  ? 128 TYR   R CD1 1 
ATOM   788  C CD2 . TYR   B 2 148 ? 125.813 124.041 129.337 1.00 85.62  ? 128 TYR   R CD2 1 
ATOM   789  C CE1 . TYR   B 2 148 ? 128.199 123.307 128.172 1.00 90.83  ? 128 TYR   R CE1 1 
ATOM   790  C CE2 . TYR   B 2 148 ? 126.713 125.015 128.933 1.00 86.28  ? 128 TYR   R CE2 1 
ATOM   791  C CZ  . TYR   B 2 148 ? 127.900 124.641 128.352 1.00 87.37  ? 128 TYR   R CZ  1 
ATOM   792  O OH  . TYR   B 2 148 ? 128.791 125.607 127.952 1.00 84.78  ? 128 TYR   R OH  1 
ATOM   793  N N   . LEU   B 2 149 ? 125.438 122.624 132.570 1.00 75.15  ? 129 LEU   R N   1 
ATOM   794  C CA  . LEU   B 2 149 ? 126.018 123.655 133.427 1.00 74.38  ? 129 LEU   R CA  1 
ATOM   795  C C   . LEU   B 2 149 ? 126.723 123.038 134.623 1.00 78.20  ? 129 LEU   R C   1 
ATOM   796  O O   . LEU   B 2 149 ? 127.902 123.307 134.872 1.00 85.75  ? 129 LEU   R O   1 
ATOM   797  C CB  . LEU   B 2 149 ? 124.944 124.619 133.927 1.00 76.13  ? 129 LEU   R CB  1 
ATOM   798  C CG  . LEU   B 2 149 ? 124.365 125.673 132.997 1.00 75.96  ? 129 LEU   R CG  1 
ATOM   799  C CD1 . LEU   B 2 149 ? 123.361 124.985 132.125 1.00 74.76  ? 129 LEU   R CD1 1 
ATOM   800  C CD2 . LEU   B 2 149 ? 123.735 126.819 133.758 1.00 75.59  ? 129 LEU   R CD2 1 
ATOM   801  N N   . MET   B 2 150 ? 126.005 122.211 135.384 1.00 77.74  ? 130 MET   R N   1 
ATOM   802  C CA  . MET   B 2 150 ? 126.552 121.675 136.622 1.00 81.67  ? 130 MET   R CA  1 
ATOM   803  C C   . MET   B 2 150 ? 127.656 120.665 136.347 1.00 88.51  ? 130 MET   R C   1 
ATOM   804  O O   . MET   B 2 150 ? 128.594 120.528 137.141 1.00 90.99  ? 130 MET   R O   1 
ATOM   805  C CB  . MET   B 2 150 ? 125.439 121.038 137.449 1.00 83.72  ? 130 MET   R CB  1 
ATOM   806  C CG  . MET   B 2 150 ? 124.318 121.983 137.810 1.00 91.84  ? 130 MET   R CG  1 
ATOM   807  S SD  . MET   B 2 150 ? 123.114 121.221 138.908 1.00 124.66 ? 130 MET   R SD  1 
ATOM   808  C CE  . MET   B 2 150 ? 123.043 122.428 140.230 1.00 113.59 ? 130 MET   R CE  1 
ATOM   809  N N   . GLY   B 2 151 ? 127.562 119.947 135.234 1.00 88.22  ? 131 GLY   R N   1 
ATOM   810  C CA  . GLY   B 2 151 ? 128.518 118.919 134.907 1.00 88.89  ? 131 GLY   R CA  1 
ATOM   811  C C   . GLY   B 2 151 ? 128.211 117.563 135.495 1.00 93.37  ? 131 GLY   R C   1 
ATOM   812  O O   . GLY   B 2 151 ? 128.897 116.592 135.158 1.00 100.07 ? 131 GLY   R O   1 
ATOM   813  N N   . THR   B 2 152 ? 127.195 117.460 136.348 1.00 92.29  ? 132 THR   R N   1 
ATOM   814  C CA  . THR   B 2 152 ? 126.822 116.204 136.981 1.00 93.78  ? 132 THR   R CA  1 
ATOM   815  C C   . THR   B 2 152 ? 125.357 115.932 136.690 1.00 90.85  ? 132 THR   R C   1 
ATOM   816  O O   . THR   B 2 152 ? 124.546 116.860 136.686 1.00 96.08  ? 132 THR   R O   1 
ATOM   817  C CB  . THR   B 2 152 ? 127.044 116.251 138.495 1.00 91.69  ? 132 THR   R CB  1 
ATOM   818  O OG1 . THR   B 2 152 ? 126.220 117.274 139.065 1.00 92.43  ? 132 THR   R OG1 1 
ATOM   819  C CG2 . THR   B 2 152 ? 128.492 116.570 138.805 1.00 86.52  ? 132 THR   R CG2 1 
ATOM   820  N N   . TRP   B 2 153 ? 125.025 114.677 136.440 1.00 87.15  ? 133 TRP   R N   1 
ATOM   821  C CA  . TRP   B 2 153 ? 123.633 114.276 136.281 1.00 86.72  ? 133 TRP   R CA  1 
ATOM   822  C C   . TRP   B 2 153 ? 122.994 114.129 137.653 1.00 92.37  ? 133 TRP   R C   1 
ATOM   823  O O   . TRP   B 2 153 ? 123.228 113.118 138.324 1.00 94.77  ? 133 TRP   R O   1 
ATOM   824  C CB  . TRP   B 2 153 ? 123.558 112.966 135.501 1.00 81.82  ? 133 TRP   R CB  1 
ATOM   825  C CG  . TRP   B 2 153 ? 122.183 112.424 135.327 1.00 75.79  ? 133 TRP   R CG  1 
ATOM   826  C CD1 . TRP   B 2 153 ? 121.580 111.474 136.086 1.00 79.97  ? 133 TRP   R CD1 1 
ATOM   827  C CD2 . TRP   B 2 153 ? 121.239 112.791 134.318 1.00 74.82  ? 133 TRP   R CD2 1 
ATOM   828  N NE1 . TRP   B 2 153 ? 120.317 111.228 135.619 1.00 81.23  ? 133 TRP   R NE1 1 
ATOM   829  C CE2 . TRP   B 2 153 ? 120.083 112.027 134.533 1.00 78.78  ? 133 TRP   R CE2 1 
ATOM   830  C CE3 . TRP   B 2 153 ? 121.258 113.696 133.256 1.00 74.23  ? 133 TRP   R CE3 1 
ATOM   831  C CZ2 . TRP   B 2 153 ? 118.957 112.138 133.726 1.00 73.73  ? 133 TRP   R CZ2 1 
ATOM   832  C CZ3 . TRP   B 2 153 ? 120.138 113.804 132.457 1.00 69.54  ? 133 TRP   R CZ3 1 
ATOM   833  C CH2 . TRP   B 2 153 ? 119.005 113.030 132.696 1.00 68.04  ? 133 TRP   R CH2 1 
ATOM   834  N N   . PRO   B 2 154 ? 122.186 115.089 138.112 1.00 94.94  ? 134 PRO   R N   1 
ATOM   835  C CA  . PRO   B 2 154 ? 121.718 115.086 139.506 1.00 92.93  ? 134 PRO   R CA  1 
ATOM   836  C C   . PRO   B 2 154 ? 120.340 114.471 139.736 1.00 95.18  ? 134 PRO   R C   1 
ATOM   837  O O   . PRO   B 2 154 ? 119.810 114.628 140.841 1.00 95.52  ? 134 PRO   R O   1 
ATOM   838  C CB  . PRO   B 2 154 ? 121.686 116.585 139.827 1.00 97.11  ? 134 PRO   R CB  1 
ATOM   839  C CG  . PRO   B 2 154 ? 121.566 117.291 138.473 1.00 92.28  ? 134 PRO   R CG  1 
ATOM   840  C CD  . PRO   B 2 154 ? 121.682 116.262 137.388 1.00 93.16  ? 134 PRO   R CD  1 
ATOM   841  N N   . PHE   B 2 155 ? 119.752 113.804 138.744 1.00 95.44  ? 135 PHE   R N   1 
ATOM   842  C CA  . PHE   B 2 155 ? 118.390 113.294 138.853 1.00 96.90  ? 135 PHE   R CA  1 
ATOM   843  C C   . PHE   B 2 155 ? 118.315 111.832 139.280 1.00 99.92  ? 135 PHE   R C   1 
ATOM   844  O O   . PHE   B 2 155 ? 117.212 111.330 139.509 1.00 99.31  ? 135 PHE   R O   1 
ATOM   845  C CB  . PHE   B 2 155 ? 117.648 113.467 137.524 1.00 85.45  ? 135 PHE   R CB  1 
ATOM   846  C CG  . PHE   B 2 155 ? 117.618 114.878 137.024 1.00 80.64  ? 135 PHE   R CG  1 
ATOM   847  C CD1 . PHE   B 2 155 ? 116.618 115.739 137.418 1.00 84.28  ? 135 PHE   R CD1 1 
ATOM   848  C CD2 . PHE   B 2 155 ? 118.589 115.342 136.161 1.00 79.24  ? 135 PHE   R CD2 1 
ATOM   849  C CE1 . PHE   B 2 155 ? 116.585 117.032 136.960 1.00 84.21  ? 135 PHE   R CE1 1 
ATOM   850  C CE2 . PHE   B 2 155 ? 118.562 116.635 135.701 1.00 78.83  ? 135 PHE   R CE2 1 
ATOM   851  C CZ  . PHE   B 2 155 ? 117.559 117.480 136.100 1.00 81.11  ? 135 PHE   R CZ  1 
ATOM   852  N N   . GLY   B 2 156 ? 119.442 111.138 139.392 1.00 96.90  ? 136 GLY   R N   1 
ATOM   853  C CA  . GLY   B 2 156 ? 119.407 109.761 139.840 1.00 94.24  ? 136 GLY   R CA  1 
ATOM   854  C C   . GLY   B 2 156 ? 119.600 108.729 138.748 1.00 97.18  ? 136 GLY   R C   1 
ATOM   855  O O   . GLY   B 2 156 ? 120.272 108.988 137.747 1.00 97.03  ? 136 GLY   R O   1 
ATOM   856  N N   . ASN   B 2 157 ? 119.013 107.548 138.939 1.00 97.17  ? 137 ASN   R N   1 
ATOM   857  C CA  . ASN   B 2 157 ? 119.232 106.403 138.060 1.00 97.36  ? 137 ASN   R CA  1 
ATOM   858  C C   . ASN   B 2 157 ? 118.051 106.165 137.120 1.00 91.66  ? 137 ASN   R C   1 
ATOM   859  O O   . ASN   B 2 157 ? 118.242 105.892 135.927 1.00 87.14  ? 137 ASN   R O   1 
ATOM   860  C CB  . ASN   B 2 157 ? 119.507 105.160 138.918 1.00 100.52 ? 137 ASN   R CB  1 
ATOM   861  C CG  . ASN   B 2 157 ? 120.096 104.014 138.126 1.00 107.99 ? 137 ASN   R CG  1 
ATOM   862  O OD1 . ASN   B 2 157 ? 120.303 104.118 136.921 1.00 110.26 ? 137 ASN   R OD1 1 
ATOM   863  N ND2 . ASN   B 2 157 ? 120.376 102.912 138.806 1.00 111.09 ? 137 ASN   R ND2 1 
ATOM   864  N N   . ILE   B 2 158 ? 116.827 106.263 137.651 1.00 90.28  ? 138 ILE   R N   1 
ATOM   865  C CA  . ILE   B 2 158 ? 115.633 105.913 136.882 1.00 89.70  ? 138 ILE   R CA  1 
ATOM   866  C C   . ILE   B 2 158 ? 115.431 106.883 135.729 1.00 91.31  ? 138 ILE   R C   1 
ATOM   867  O O   . ILE   B 2 158 ? 115.115 106.476 134.603 1.00 88.75  ? 138 ILE   R O   1 
ATOM   868  C CB  . ILE   B 2 158 ? 114.391 105.879 137.790 1.00 84.98  ? 138 ILE   R CB  1 
ATOM   869  C CG1 . ILE   B 2 158 ? 114.603 104.950 138.983 1.00 90.03  ? 138 ILE   R CG1 1 
ATOM   870  C CG2 . ILE   B 2 158 ? 113.194 105.420 137.000 1.00 81.75  ? 138 ILE   R CG2 1 
ATOM   871  C CD1 . ILE   B 2 158 ? 115.024 105.680 140.242 1.00 89.45  ? 138 ILE   R CD1 1 
ATOM   872  N N   . LEU   B 2 159 ? 115.601 108.181 135.991 1.00 90.25  ? 139 LEU   R N   1 
ATOM   873  C CA  . LEU   B 2 159 ? 115.422 109.179 134.945 1.00 81.63  ? 139 LEU   R CA  1 
ATOM   874  C C   . LEU   B 2 159 ? 116.484 109.052 133.866 1.00 82.20  ? 139 LEU   R C   1 
ATOM   875  O O   . LEU   B 2 159 ? 116.200 109.276 132.685 1.00 82.28  ? 139 LEU   R O   1 
ATOM   876  C CB  . LEU   B 2 159 ? 115.445 110.577 135.548 1.00 78.97  ? 139 LEU   R CB  1 
ATOM   877  C CG  . LEU   B 2 159 ? 115.150 111.671 134.534 1.00 87.15  ? 139 LEU   R CG  1 
ATOM   878  C CD1 . LEU   B 2 159 ? 113.776 111.455 133.937 1.00 83.04  ? 139 LEU   R CD1 1 
ATOM   879  C CD2 . LEU   B 2 159 ? 115.244 113.030 135.190 1.00 91.84  ? 139 LEU   R CD2 1 
ATOM   880  N N   . CYS   B 2 160 ? 117.705 108.686 134.252 1.00 82.32  ? 140 CYS   R N   1 
ATOM   881  C CA  . CYS   B 2 160 ? 118.768 108.432 133.289 1.00 81.06  ? 140 CYS   R CA  1 
ATOM   882  C C   . CYS   B 2 160 ? 118.431 107.259 132.380 1.00 74.95  ? 140 CYS   R C   1 
ATOM   883  O O   . CYS   B 2 160 ? 118.631 107.329 131.155 1.00 70.40  ? 140 CYS   R O   1 
ATOM   884  C CB  . CYS   B 2 160 ? 120.066 108.167 134.038 1.00 83.33  ? 140 CYS   R CB  1 
ATOM   885  S SG  . CYS   B 2 160 ? 121.421 107.711 133.000 1.00 89.36  ? 140 CYS   R SG  1 
ATOM   886  N N   . LYS   B 2 161 ? 117.905 106.188 132.977 1.00 73.55  ? 141 LYS   R N   1 
ATOM   887  C CA  . LYS   B 2 161 ? 117.451 105.032 132.213 1.00 74.21  ? 141 LYS   R CA  1 
ATOM   888  C C   . LYS   B 2 161 ? 116.343 105.422 131.239 1.00 70.40  ? 141 LYS   R C   1 
ATOM   889  O O   . LYS   B 2 161 ? 116.347 105.012 130.070 1.00 65.83  ? 141 LYS   R O   1 
ATOM   890  C CB  . LYS   B 2 161 ? 116.972 103.954 133.186 1.00 79.67  ? 141 LYS   R CB  1 
ATOM   891  C CG  . LYS   B 2 161 ? 116.993 102.533 132.663 1.00 80.09  ? 141 LYS   R CG  1 
ATOM   892  C CD  . LYS   B 2 161 ? 116.458 101.574 133.719 1.00 82.51  ? 141 LYS   R CD  1 
ATOM   893  C CE  . LYS   B 2 161 ? 117.578 100.971 134.551 1.00 83.89  ? 141 LYS   R CE  1 
ATOM   894  N NZ  . LYS   B 2 161 ? 118.366 99.966  133.787 1.00 85.69  ? 141 LYS   R NZ  1 
ATOM   895  N N   . ILE   B 2 162 ? 115.408 106.257 131.702 1.00 68.82  ? 142 ILE   R N   1 
ATOM   896  C CA  . ILE   B 2 162 ? 114.286 106.682 130.867 1.00 60.75  ? 142 ILE   R CA  1 
ATOM   897  C C   . ILE   B 2 162 ? 114.758 107.535 129.700 1.00 66.42  ? 142 ILE   R C   1 
ATOM   898  O O   . ILE   B 2 162 ? 114.252 107.403 128.581 1.00 71.30  ? 142 ILE   R O   1 
ATOM   899  C CB  . ILE   B 2 162 ? 113.241 107.429 131.705 1.00 57.14  ? 142 ILE   R CB  1 
ATOM   900  C CG1 . ILE   B 2 162 ? 112.619 106.481 132.720 1.00 61.45  ? 142 ILE   R CG1 1 
ATOM   901  C CG2 . ILE   B 2 162 ? 112.196 108.022 130.799 1.00 58.50  ? 142 ILE   R CG2 1 
ATOM   902  C CD1 . ILE   B 2 162 ? 111.945 105.301 132.082 1.00 59.57  ? 142 ILE   R CD1 1 
ATOM   903  N N   . VAL   B 2 163 ? 115.716 108.433 129.937 1.00 65.13  ? 143 VAL   R N   1 
ATOM   904  C CA  . VAL   B 2 163 ? 116.196 109.307 128.869 1.00 57.73  ? 143 VAL   R CA  1 
ATOM   905  C C   . VAL   B 2 163 ? 116.931 108.499 127.804 1.00 61.53  ? 143 VAL   R C   1 
ATOM   906  O O   . VAL   B 2 163 ? 116.735 108.704 126.592 1.00 62.94  ? 143 VAL   R O   1 
ATOM   907  C CB  . VAL   B 2 163 ? 117.085 110.417 129.451 1.00 54.26  ? 143 VAL   R CB  1 
ATOM   908  C CG1 . VAL   B 2 163 ? 117.842 111.120 128.343 1.00 61.41  ? 143 VAL   R CG1 1 
ATOM   909  C CG2 . VAL   B 2 163 ? 116.249 111.394 130.235 1.00 60.58  ? 143 VAL   R CG2 1 
ATOM   910  N N   . ILE   B 2 164 ? 117.779 107.557 128.239 1.00 61.58  ? 144 ILE   R N   1 
ATOM   911  C CA  . ILE   B 2 164 ? 118.525 106.743 127.283 1.00 57.25  ? 144 ILE   R CA  1 
ATOM   912  C C   . ILE   B 2 164 ? 117.583 105.854 126.478 1.00 55.79  ? 144 ILE   R C   1 
ATOM   913  O O   . ILE   B 2 164 ? 117.814 105.607 125.291 1.00 59.26  ? 144 ILE   R O   1 
ATOM   914  C CB  . ILE   B 2 164 ? 119.604 105.909 127.993 1.00 56.14  ? 144 ILE   R CB  1 
ATOM   915  C CG1 . ILE   B 2 164 ? 120.589 106.798 128.746 1.00 58.28  ? 144 ILE   R CG1 1 
ATOM   916  C CG2 . ILE   B 2 164 ? 120.374 105.107 126.977 1.00 51.94  ? 144 ILE   R CG2 1 
ATOM   917  C CD1 . ILE   B 2 164 ? 121.348 107.749 127.870 1.00 63.04  ? 144 ILE   R CD1 1 
ATOM   918  N N   . SER   B 2 165 ? 116.508 105.363 127.100 1.00 53.14  ? 145 SER   R N   1 
ATOM   919  C CA  . SER   B 2 165 ? 115.524 104.590 126.346 1.00 54.23  ? 145 SER   R CA  1 
ATOM   920  C C   . SER   B 2 165 ? 114.751 105.469 125.367 1.00 58.69  ? 145 SER   R C   1 
ATOM   921  O O   . SER   B 2 165 ? 114.425 105.039 124.249 1.00 62.89  ? 145 SER   R O   1 
ATOM   922  C CB  . SER   B 2 165 ? 114.568 103.892 127.308 1.00 58.12  ? 145 SER   R CB  1 
ATOM   923  O OG  . SER   B 2 165 ? 113.484 103.314 126.610 1.00 60.57  ? 145 SER   R OG  1 
ATOM   924  N N   . ILE   B 2 166 ? 114.431 106.699 125.783 1.00 58.92  ? 146 ILE   R N   1 
ATOM   925  C CA  . ILE   B 2 166 ? 113.612 107.600 124.979 1.00 56.69  ? 146 ILE   R CA  1 
ATOM   926  C C   . ILE   B 2 166 ? 114.337 108.007 123.709 1.00 59.35  ? 146 ILE   R C   1 
ATOM   927  O O   . ILE   B 2 166 ? 113.697 108.236 122.677 1.00 64.33  ? 146 ILE   R O   1 
ATOM   928  C CB  . ILE   B 2 166 ? 113.199 108.818 125.823 1.00 51.27  ? 146 ILE   R CB  1 
ATOM   929  C CG1 . ILE   B 2 166 ? 112.016 108.460 126.713 1.00 53.65  ? 146 ILE   R CG1 1 
ATOM   930  C CG2 . ILE   B 2 166 ? 112.849 109.996 124.955 1.00 54.85  ? 146 ILE   R CG2 1 
ATOM   931  C CD1 . ILE   B 2 166 ? 111.706 109.507 127.739 1.00 57.35  ? 146 ILE   R CD1 1 
ATOM   932  N N   . ASP   B 2 167 ? 115.673 108.081 123.755 1.00 56.49  ? 147 ASP   R N   1 
ATOM   933  C CA  . ASP   B 2 167 ? 116.450 108.370 122.544 1.00 55.00  ? 147 ASP   R CA  1 
ATOM   934  C C   . ASP   B 2 167 ? 116.242 107.308 121.460 1.00 57.54  ? 147 ASP   R C   1 
ATOM   935  O O   . ASP   B 2 167 ? 116.032 107.629 120.279 1.00 59.24  ? 147 ASP   R O   1 
ATOM   936  C CB  . ASP   B 2 167 ? 117.930 108.473 122.892 1.00 55.22  ? 147 ASP   R CB  1 
ATOM   937  C CG  . ASP   B 2 167 ? 118.382 109.890 123.071 1.00 62.92  ? 147 ASP   R CG  1 
ATOM   938  O OD1 . ASP   B 2 167 ? 117.539 110.795 122.925 1.00 68.08  ? 147 ASP   R OD1 1 
ATOM   939  O OD2 . ASP   B 2 167 ? 119.578 110.102 123.353 1.00 61.74  ? 147 ASP   R OD2 1 
ATOM   940  N N   . TYR   B 2 168 ? 116.276 106.034 121.846 1.00 55.04  ? 148 TYR   R N   1 
ATOM   941  C CA  . TYR   B 2 168 ? 116.156 104.970 120.856 1.00 50.16  ? 148 TYR   R CA  1 
ATOM   942  C C   . TYR   B 2 168 ? 114.713 104.775 120.398 1.00 51.32  ? 148 TYR   R C   1 
ATOM   943  O O   . TYR   B 2 168 ? 114.481 104.451 119.225 1.00 55.42  ? 148 TYR   R O   1 
ATOM   944  C CB  . TYR   B 2 168 ? 116.757 103.681 121.405 1.00 52.09  ? 148 TYR   R CB  1 
ATOM   945  C CG  . TYR   B 2 168 ? 118.272 103.724 121.460 1.00 54.95  ? 148 TYR   R CG  1 
ATOM   946  C CD1 . TYR   B 2 168 ? 118.936 104.334 122.512 1.00 54.01  ? 148 TYR   R CD1 1 
ATOM   947  C CD2 . TYR   B 2 168 ? 119.035 103.179 120.443 1.00 57.72  ? 148 TYR   R CD2 1 
ATOM   948  C CE1 . TYR   B 2 168 ? 120.310 104.381 122.558 1.00 48.70  ? 148 TYR   R CE1 1 
ATOM   949  C CE2 . TYR   B 2 168 ? 120.408 103.223 120.482 1.00 57.75  ? 148 TYR   R CE2 1 
ATOM   950  C CZ  . TYR   B 2 168 ? 121.038 103.824 121.541 1.00 52.34  ? 148 TYR   R CZ  1 
ATOM   951  O OH  . TYR   B 2 168 ? 122.407 103.869 121.582 1.00 52.50  ? 148 TYR   R OH  1 
ATOM   952  N N   . TYR   B 2 169 ? 113.729 104.973 121.289 1.00 50.58  ? 149 TYR   R N   1 
ATOM   953  C CA  . TYR   B 2 169 ? 112.341 105.070 120.822 1.00 50.61  ? 149 TYR   R CA  1 
ATOM   954  C C   . TYR   B 2 169 ? 112.138 106.197 119.824 1.00 46.94  ? 149 TYR   R C   1 
ATOM   955  O O   . TYR   B 2 169 ? 111.428 106.014 118.830 1.00 50.93  ? 149 TYR   R O   1 
ATOM   956  C CB  . TYR   B 2 169 ? 111.346 105.214 121.970 1.00 59.70  ? 149 TYR   R CB  1 
ATOM   957  C CG  . TYR   B 2 169 ? 111.153 103.997 122.821 1.00 72.99  ? 149 TYR   R CG  1 
ATOM   958  C CD1 . TYR   B 2 169 ? 111.589 102.761 122.392 1.00 72.39  ? 149 TYR   R CD1 1 
ATOM   959  C CD2 . TYR   B 2 169 ? 110.463 104.070 124.018 1.00 81.08  ? 149 TYR   R CD2 1 
ATOM   960  C CE1 . TYR   B 2 169 ? 111.379 101.638 123.144 1.00 75.10  ? 149 TYR   R CE1 1 
ATOM   961  C CE2 . TYR   B 2 169 ? 110.250 102.951 124.783 1.00 84.86  ? 149 TYR   R CE2 1 
ATOM   962  C CZ  . TYR   B 2 169 ? 110.709 101.735 124.339 1.00 84.97  ? 149 TYR   R CZ  1 
ATOM   963  O OH  . TYR   B 2 169 ? 110.500 100.609 125.099 1.00 94.41  ? 149 TYR   R OH  1 
ATOM   964  N N   . ASN   B 2 170 ? 112.750 107.359 120.071 1.00 45.75  ? 150 ASN   R N   1 
ATOM   965  C CA  . ASN   B 2 170 ? 112.677 108.488 119.148 1.00 46.05  ? 150 ASN   R CA  1 
ATOM   966  C C   . ASN   B 2 170 ? 113.192 108.114 117.767 1.00 45.01  ? 150 ASN   R C   1 
ATOM   967  O O   . ASN   B 2 170 ? 112.469 108.242 116.772 1.00 51.24  ? 150 ASN   R O   1 
ATOM   968  C CB  . ASN   B 2 170 ? 113.483 109.657 119.712 1.00 52.67  ? 150 ASN   R CB  1 
ATOM   969  C CG  . ASN   B 2 170 ? 113.587 110.816 118.750 1.00 60.94  ? 150 ASN   R CG  1 
ATOM   970  O OD1 . ASN   B 2 170 ? 112.692 111.062 117.944 1.00 68.51  ? 150 ASN   R OD1 1 
ATOM   971  N ND2 . ASN   B 2 170 ? 114.692 111.540 118.829 1.00 59.56  ? 150 ASN   R ND2 1 
ATOM   972  N N   . MET   B 2 171 ? 114.403 107.558 117.710 1.00 45.72  ? 151 MET   R N   1 
ATOM   973  C CA  . MET   B 2 171 ? 115.025 107.246 116.424 1.00 45.11  ? 151 MET   R CA  1 
ATOM   974  C C   . MET   B 2 171 ? 114.259 106.157 115.670 1.00 45.19  ? 151 MET   R C   1 
ATOM   975  O O   . MET   B 2 171 ? 113.869 106.345 114.506 1.00 51.77  ? 151 MET   R O   1 
ATOM   976  C CB  . MET   B 2 171 ? 116.476 106.837 116.657 1.00 52.26  ? 151 MET   R CB  1 
ATOM   977  C CG  . MET   B 2 171 ? 117.291 106.656 115.410 1.00 57.41  ? 151 MET   R CG  1 
ATOM   978  S SD  . MET   B 2 171 ? 119.042 106.634 115.805 1.00 66.73  ? 151 MET   R SD  1 
ATOM   979  C CE  . MET   B 2 171 ? 119.000 105.847 117.405 1.00 54.06  ? 151 MET   R CE  1 
ATOM   980  N N   . PHE   B 2 172 ? 113.963 105.040 116.342 1.00 44.30  ? 152 PHE   R N   1 
ATOM   981  C CA  . PHE   B 2 172 ? 113.334 103.918 115.655 1.00 44.00  ? 152 PHE   R CA  1 
ATOM   982  C C   . PHE   B 2 172 ? 111.888 104.219 115.262 1.00 49.05  ? 152 PHE   R C   1 
ATOM   983  O O   . PHE   B 2 172 ? 111.481 103.936 114.131 1.00 55.37  ? 152 PHE   R O   1 
ATOM   984  C CB  . PHE   B 2 172 ? 113.412 102.668 116.522 1.00 46.08  ? 152 PHE   R CB  1 
ATOM   985  C CG  . PHE   B 2 172 ? 114.700 101.924 116.390 1.00 52.60  ? 152 PHE   R CG  1 
ATOM   986  C CD1 . PHE   B 2 172 ? 115.805 102.295 117.125 1.00 56.25  ? 152 PHE   R CD1 1 
ATOM   987  C CD2 . PHE   B 2 172 ? 114.804 100.847 115.530 1.00 60.77  ? 152 PHE   R CD2 1 
ATOM   988  C CE1 . PHE   B 2 172 ? 116.994 101.607 117.006 1.00 62.54  ? 152 PHE   R CE1 1 
ATOM   989  C CE2 . PHE   B 2 172 ? 115.991 100.154 115.405 1.00 67.06  ? 152 PHE   R CE2 1 
ATOM   990  C CZ  . PHE   B 2 172 ? 117.087 100.535 116.144 1.00 65.38  ? 152 PHE   R CZ  1 
ATOM   991  N N   . THR   B 2 173 ? 111.084 104.785 116.169 1.00 48.60  ? 153 THR   R N   1 
ATOM   992  C CA  . THR   B 2 173 ? 109.691 105.031 115.820 1.00 47.83  ? 153 THR   R CA  1 
ATOM   993  C C   . THR   B 2 173 ? 109.556 106.162 114.812 1.00 48.82  ? 153 THR   R C   1 
ATOM   994  O O   . THR   B 2 173 ? 108.678 106.113 113.941 1.00 55.01  ? 153 THR   R O   1 
ATOM   995  C CB  . THR   B 2 173 ? 108.871 105.327 117.066 1.00 53.48  ? 153 THR   R CB  1 
ATOM   996  O OG1 . THR   B 2 173 ? 109.272 106.586 117.611 1.00 56.39  ? 153 THR   R OG1 1 
ATOM   997  C CG2 . THR   B 2 173 ? 109.081 104.239 118.088 1.00 65.26  ? 153 THR   R CG2 1 
ATOM   998  N N   . SER   B 2 174 ? 110.412 107.188 114.894 1.00 47.45  ? 154 SER   R N   1 
ATOM   999  C CA  . SER   B 2 174 ? 110.364 108.234 113.887 1.00 48.77  ? 154 SER   R CA  1 
ATOM   1000 C C   . SER   B 2 174 ? 110.774 107.735 112.511 1.00 52.77  ? 154 SER   R C   1 
ATOM   1001 O O   . SER   B 2 174 ? 110.286 108.270 111.514 1.00 55.81  ? 154 SER   R O   1 
ATOM   1002 C CB  . SER   B 2 174 ? 111.250 109.404 114.299 1.00 48.97  ? 154 SER   R CB  1 
ATOM   1003 O OG  . SER   B 2 174 ? 110.610 110.198 115.280 1.00 46.86  ? 154 SER   R OG  1 
ATOM   1004 N N   . ILE   B 2 175 ? 111.643 106.727 112.416 1.00 51.84  ? 155 ILE   R N   1 
ATOM   1005 C CA  . ILE   B 2 175 ? 111.944 106.175 111.099 1.00 51.28  ? 155 ILE   R CA  1 
ATOM   1006 C C   . ILE   B 2 175 ? 110.932 105.131 110.628 1.00 52.20  ? 155 ILE   R C   1 
ATOM   1007 O O   . ILE   B 2 175 ? 110.799 104.926 109.414 1.00 57.31  ? 155 ILE   R O   1 
ATOM   1008 C CB  . ILE   B 2 175 ? 113.369 105.590 111.046 1.00 52.10  ? 155 ILE   R CB  1 
ATOM   1009 C CG1 . ILE   B 2 175 ? 113.775 105.303 109.599 1.00 54.34  ? 155 ILE   R CG1 1 
ATOM   1010 C CG2 . ILE   B 2 175 ? 113.454 104.335 111.864 1.00 53.11  ? 155 ILE   R CG2 1 
ATOM   1011 C CD1 . ILE   B 2 175 ? 113.909 106.526 108.734 1.00 51.29  ? 155 ILE   R CD1 1 
ATOM   1012 N N   . PHE   B 2 176 ? 110.209 104.477 111.537 1.00 52.01  ? 156 PHE   R N   1 
ATOM   1013 C CA  . PHE   B 2 176 ? 109.250 103.469 111.086 1.00 53.21  ? 156 PHE   R CA  1 
ATOM   1014 C C   . PHE   B 2 176 ? 107.900 104.077 110.727 1.00 59.92  ? 156 PHE   R C   1 
ATOM   1015 O O   . PHE   B 2 176 ? 107.211 103.573 109.829 1.00 64.50  ? 156 PHE   R O   1 
ATOM   1016 C CB  . PHE   B 2 176 ? 109.067 102.391 112.147 1.00 47.77  ? 156 PHE   R CB  1 
ATOM   1017 C CG  . PHE   B 2 176 ? 110.224 101.460 112.265 1.00 53.72  ? 156 PHE   R CG  1 
ATOM   1018 C CD1 . PHE   B 2 176 ? 111.162 101.375 111.259 1.00 56.86  ? 156 PHE   R CD1 1 
ATOM   1019 C CD2 . PHE   B 2 176 ? 110.378 100.670 113.384 1.00 58.99  ? 156 PHE   R CD2 1 
ATOM   1020 C CE1 . PHE   B 2 176 ? 112.231 100.519 111.369 1.00 58.51  ? 156 PHE   R CE1 1 
ATOM   1021 C CE2 . PHE   B 2 176 ? 111.446 99.813  113.497 1.00 58.68  ? 156 PHE   R CE2 1 
ATOM   1022 C CZ  . PHE   B 2 176 ? 112.372 99.738  112.490 1.00 59.29  ? 156 PHE   R CZ  1 
ATOM   1023 N N   . THR   B 2 177 ? 107.492 105.143 111.422 1.00 56.64  ? 157 THR   R N   1 
ATOM   1024 C CA  . THR   B 2 177 ? 106.219 105.779 111.102 1.00 54.86  ? 157 THR   R CA  1 
ATOM   1025 C C   . THR   B 2 177 ? 106.238 106.411 109.718 1.00 62.53  ? 157 THR   R C   1 
ATOM   1026 O O   . THR   B 2 177 ? 105.230 106.370 109.012 1.00 69.50  ? 157 THR   R O   1 
ATOM   1027 C CB  . THR   B 2 177 ? 105.868 106.821 112.158 1.00 54.66  ? 157 THR   R CB  1 
ATOM   1028 O OG1 . THR   B 2 177 ? 105.547 106.159 113.383 1.00 66.23  ? 157 THR   R OG1 1 
ATOM   1029 C CG2 . THR   B 2 177 ? 104.676 107.633 111.718 1.00 55.64  ? 157 THR   R CG2 1 
ATOM   1030 N N   . LEU   B 2 178 ? 107.372 106.979 109.302 1.00 61.41  ? 158 LEU   R N   1 
ATOM   1031 C CA  . LEU   B 2 178 ? 107.479 107.525 107.953 1.00 56.02  ? 158 LEU   R CA  1 
ATOM   1032 C C   . LEU   B 2 178 ? 107.373 106.436 106.894 1.00 55.06  ? 158 LEU   R C   1 
ATOM   1033 O O   . LEU   B 2 178 ? 106.734 106.642 105.856 1.00 58.03  ? 158 LEU   R O   1 
ATOM   1034 C CB  . LEU   B 2 178 ? 108.795 108.277 107.800 1.00 50.17  ? 158 LEU   R CB  1 
ATOM   1035 C CG  . LEU   B 2 178 ? 108.902 109.603 108.544 1.00 52.51  ? 158 LEU   R CG  1 
ATOM   1036 C CD1 . LEU   B 2 178 ? 110.216 110.262 108.218 1.00 55.73  ? 158 LEU   R CD1 1 
ATOM   1037 C CD2 . LEU   B 2 178 ? 107.753 110.508 108.185 1.00 55.50  ? 158 LEU   R CD2 1 
ATOM   1038 N N   . CYS   B 2 179 ? 107.982 105.276 107.141 1.00 52.36  ? 159 CYS   R N   1 
ATOM   1039 C CA  . CYS   B 2 179 ? 107.882 104.155 106.210 1.00 53.07  ? 159 CYS   R CA  1 
ATOM   1040 C C   . CYS   B 2 179 ? 106.448 103.650 106.090 1.00 55.16  ? 159 CYS   R C   1 
ATOM   1041 O O   . CYS   B 2 179 ? 105.954 103.411 104.977 1.00 60.11  ? 159 CYS   R O   1 
ATOM   1042 C CB  . CYS   B 2 179 ? 108.811 103.032 106.664 1.00 55.54  ? 159 CYS   R CB  1 
ATOM   1043 S SG  . CYS   B 2 179 ? 108.835 101.597 105.598 1.00 62.54  ? 159 CYS   R SG  1 
ATOM   1044 N N   . THR   B 2 180 ? 105.753 103.496 107.219 1.00 55.85  ? 160 THR   R N   1 
ATOM   1045 C CA  . THR   B 2 180 ? 104.374 103.023 107.144 1.00 60.61  ? 160 THR   R CA  1 
ATOM   1046 C C   . THR   B 2 180 ? 103.453 104.084 106.541 1.00 62.39  ? 160 THR   R C   1 
ATOM   1047 O O   . THR   B 2 180 ? 102.487 103.748 105.846 1.00 66.77  ? 160 THR   R O   1 
ATOM   1048 C CB  . THR   B 2 180 ? 103.886 102.572 108.519 1.00 60.23  ? 160 THR   R CB  1 
ATOM   1049 O OG1 . THR   B 2 180 ? 102.595 101.969 108.392 1.00 61.23  ? 160 THR   R OG1 1 
ATOM   1050 C CG2 . THR   B 2 180 ? 103.795 103.732 109.472 1.00 63.34  ? 160 THR   R CG2 1 
ATOM   1051 N N   . MET   B 2 181 ? 103.760 105.368 106.751 1.00 57.07  ? 161 MET   R N   1 
ATOM   1052 C CA  . MET   B 2 181 ? 103.001 106.439 106.110 1.00 53.09  ? 161 MET   R CA  1 
ATOM   1053 C C   . MET   B 2 181 ? 103.175 106.417 104.597 1.00 57.34  ? 161 MET   R C   1 
ATOM   1054 O O   . MET   B 2 181 ? 102.206 106.602 103.852 1.00 65.58  ? 161 MET   R O   1 
ATOM   1055 C CB  . MET   B 2 181 ? 103.436 107.789 106.675 1.00 55.42  ? 161 MET   R CB  1 
ATOM   1056 C CG  . MET   B 2 181 ? 102.349 108.834 106.728 1.00 63.68  ? 161 MET   R CG  1 
ATOM   1057 S SD  . MET   B 2 181 ? 102.624 110.052 108.029 1.00 81.02  ? 161 MET   R SD  1 
ATOM   1058 C CE  . MET   B 2 181 ? 103.903 111.067 107.311 1.00 62.77  ? 161 MET   R CE  1 
ATOM   1059 N N   . SER   B 2 182 ? 104.402 106.192 104.122 1.00 58.66  ? 162 SER   R N   1 
ATOM   1060 C CA  . SER   B 2 182 ? 104.630 106.128 102.682 1.00 56.68  ? 162 SER   R CA  1 
ATOM   1061 C C   . SER   B 2 182 ? 103.950 104.918 102.057 1.00 56.80  ? 162 SER   R C   1 
ATOM   1062 O O   . SER   B 2 182 ? 103.422 105.007 100.944 1.00 60.67  ? 162 SER   R O   1 
ATOM   1063 C CB  . SER   B 2 182 ? 106.123 106.117 102.377 1.00 55.15  ? 162 SER   R CB  1 
ATOM   1064 O OG  . SER   B 2 182 ? 106.725 107.332 102.777 1.00 59.83  ? 162 SER   R OG  1 
ATOM   1065 N N   . VAL   B 2 183 ? 103.957 103.775 102.743 1.00 56.56  ? 163 VAL   R N   1 
ATOM   1066 C CA  . VAL   B 2 183 ? 103.266 102.609 102.193 1.00 53.34  ? 163 VAL   R CA  1 
ATOM   1067 C C   . VAL   B 2 183 ? 101.752 102.828 102.182 1.00 58.43  ? 163 VAL   R C   1 
ATOM   1068 O O   . VAL   B 2 183 ? 101.052 102.367 101.270 1.00 62.55  ? 163 VAL   R O   1 
ATOM   1069 C CB  . VAL   B 2 183 ? 103.654 101.335 102.957 1.00 48.54  ? 163 VAL   R CB  1 
ATOM   1070 C CG1 . VAL   B 2 183 ? 102.956 100.149 102.346 1.00 48.56  ? 163 VAL   R CG1 1 
ATOM   1071 C CG2 . VAL   B 2 183 ? 105.148 101.138 102.910 1.00 49.96  ? 163 VAL   R CG2 1 
ATOM   1072 N N   . ASP   B 2 184 ? 101.224 103.531 103.190 1.00 54.92  ? 164 ASP   R N   1 
ATOM   1073 C CA  . ASP   B 2 184 ? 99.818  103.926 103.167 1.00 56.21  ? 164 ASP   R CA  1 
ATOM   1074 C C   . ASP   B 2 184 ? 99.499  104.817 101.981 1.00 60.63  ? 164 ASP   R C   1 
ATOM   1075 O O   . ASP   B 2 184 ? 98.465  104.647 101.324 1.00 67.57  ? 164 ASP   R O   1 
ATOM   1076 C CB  . ASP   B 2 184 ? 99.454  104.655 104.453 1.00 64.73  ? 164 ASP   R CB  1 
ATOM   1077 C CG  . ASP   B 2 184 ? 97.993  105.024 104.509 1.00 74.84  ? 164 ASP   R CG  1 
ATOM   1078 O OD1 . ASP   B 2 184 ? 97.148  104.133 104.728 1.00 78.95  ? 164 ASP   R OD1 1 
ATOM   1079 O OD2 . ASP   B 2 184 ? 97.690  106.218 104.322 1.00 72.03  ? 164 ASP   R OD2 1 
ATOM   1080 N N   . ARG   B 2 185 ? 100.363 105.785 101.704 1.00 60.16  ? 165 ARG   R N   1 
ATOM   1081 C CA  . ARG   B 2 185 ? 100.110 106.687 100.592 1.00 61.50  ? 165 ARG   R CA  1 
ATOM   1082 C C   . ARG   B 2 185 ? 100.220 105.952 99.259  1.00 63.69  ? 165 ARG   R C   1 
ATOM   1083 O O   . ARG   B 2 185 ? 99.489  106.266 98.313  1.00 67.74  ? 165 ARG   R O   1 
ATOM   1084 C CB  . ARG   B 2 185 ? 101.065 107.872 100.687 1.00 56.63  ? 165 ARG   R CB  1 
ATOM   1085 C CG  . ARG   B 2 185 ? 100.834 108.926 99.672  1.00 63.13  ? 165 ARG   R CG  1 
ATOM   1086 C CD  . ARG   B 2 185 ? 99.397  109.372 99.732  1.00 74.37  ? 165 ARG   R CD  1 
ATOM   1087 N NE  . ARG   B 2 185 ? 99.011  109.851 101.051 1.00 67.72  ? 165 ARG   R NE  1 
ATOM   1088 C CZ  . ARG   B 2 185 ? 97.758  110.074 101.421 1.00 74.14  ? 165 ARG   R CZ  1 
ATOM   1089 N NH1 . ARG   B 2 185 ? 96.747  109.881 100.591 1.00 67.20  ? 165 ARG   R NH1 1 
ATOM   1090 N NH2 . ARG   B 2 185 ? 97.514  110.504 102.653 1.00 80.18  ? 165 ARG   R NH2 1 
ATOM   1091 N N   . TYR   B 2 186 ? 101.091 104.940 99.190  1.00 63.60  ? 166 TYR   R N   1 
ATOM   1092 C CA  . TYR   B 2 186 ? 101.144 104.054 98.029  1.00 62.79  ? 166 TYR   R CA  1 
ATOM   1093 C C   . TYR   B 2 186 ? 99.840  103.307 97.815  1.00 66.06  ? 166 TYR   R C   1 
ATOM   1094 O O   . TYR   B 2 186 ? 99.352  103.213 96.679  1.00 68.69  ? 166 TYR   R O   1 
ATOM   1095 C CB  . TYR   B 2 186 ? 102.282 103.051 98.191  1.00 64.99  ? 166 TYR   R CB  1 
ATOM   1096 C CG  . TYR   B 2 186 ? 102.405 102.110 97.030  1.00 62.48  ? 166 TYR   R CG  1 
ATOM   1097 C CD1 . TYR   B 2 186 ? 102.947 102.517 95.837  1.00 63.58  ? 166 TYR   R CD1 1 
ATOM   1098 C CD2 . TYR   B 2 186 ? 101.979 100.797 97.142  1.00 67.47  ? 166 TYR   R CD2 1 
ATOM   1099 C CE1 . TYR   B 2 186 ? 103.046 101.648 94.778  1.00 70.77  ? 166 TYR   R CE1 1 
ATOM   1100 C CE2 . TYR   B 2 186 ? 102.077 99.927  96.095  1.00 71.74  ? 166 TYR   R CE2 1 
ATOM   1101 C CZ  . TYR   B 2 186 ? 102.616 100.355 94.914  1.00 73.83  ? 166 TYR   R CZ  1 
ATOM   1102 O OH  . TYR   B 2 186 ? 102.724 99.490  93.854  1.00 81.71  ? 166 TYR   R OH  1 
ATOM   1103 N N   . ILE   B 2 187 ? 99.292  102.734 98.888  1.00 67.30  ? 167 ILE   R N   1 
ATOM   1104 C CA  . ILE   B 2 187 ? 98.033  102.004 98.786  1.00 72.11  ? 167 ILE   R CA  1 
ATOM   1105 C C   . ILE   B 2 187 ? 96.916  102.939 98.355  1.00 73.18  ? 167 ILE   R C   1 
ATOM   1106 O O   . ILE   B 2 187 ? 96.062  102.574 97.539  1.00 75.53  ? 167 ILE   R O   1 
ATOM   1107 C CB  . ILE   B 2 187 ? 97.704  101.315 100.122 1.00 70.01  ? 167 ILE   R CB  1 
ATOM   1108 C CG1 . ILE   B 2 187 ? 98.758  100.267 100.460 1.00 60.72  ? 167 ILE   R CG1 1 
ATOM   1109 C CG2 . ILE   B 2 187 ? 96.333  100.678 100.068 1.00 77.59  ? 167 ILE   R CG2 1 
ATOM   1110 C CD1 . ILE   B 2 187 ? 98.654  99.770  101.866 1.00 59.59  ? 167 ILE   R CD1 1 
ATOM   1111 N N   . ALA   B 2 188 ? 96.924  104.168 98.874  1.00 70.10  ? 168 ALA   R N   1 
ATOM   1112 C CA  . ALA   B 2 188 ? 95.897  105.142 98.518  1.00 71.35  ? 168 ALA   R CA  1 
ATOM   1113 C C   . ALA   B 2 188 ? 95.979  105.534 97.050  1.00 73.51  ? 168 ALA   R C   1 
ATOM   1114 O O   . ALA   B 2 188 ? 94.956  105.623 96.364  1.00 81.41  ? 168 ALA   R O   1 
ATOM   1115 C CB  . ALA   B 2 188 ? 96.026  106.378 99.403  1.00 71.23  ? 168 ALA   R CB  1 
ATOM   1116 N N   . VAL   B 2 189 ? 97.188  105.768 96.542  1.00 70.56  ? 169 VAL   R N   1 
ATOM   1117 C CA  . VAL   B 2 189 ? 97.298  106.316 95.195  1.00 69.93  ? 169 VAL   R CA  1 
ATOM   1118 C C   . VAL   B 2 189 ? 97.176  105.223 94.140  1.00 75.36  ? 169 VAL   R C   1 
ATOM   1119 O O   . VAL   B 2 189 ? 96.299  105.286 93.271  1.00 77.41  ? 169 VAL   R O   1 
ATOM   1120 C CB  . VAL   B 2 189 ? 98.604  107.105 95.037  1.00 66.42  ? 169 VAL   R CB  1 
ATOM   1121 C CG1 . VAL   B 2 189 ? 98.842  107.397 93.578  1.00 64.78  ? 169 VAL   R CG1 1 
ATOM   1122 C CG2 . VAL   B 2 189 ? 98.529  108.388 95.826  1.00 63.11  ? 169 VAL   R CG2 1 
ATOM   1123 N N   . CYS   B 2 190 ? 98.040  104.209 94.184  1.00 79.76  ? 170 CYS   R N   1 
ATOM   1124 C CA  . CYS   B 2 190 ? 98.129  103.271 93.070  1.00 79.26  ? 170 CYS   R CA  1 
ATOM   1125 C C   . CYS   B 2 190 ? 97.197  102.072 93.194  1.00 86.07  ? 170 CYS   R C   1 
ATOM   1126 O O   . CYS   B 2 190 ? 97.105  101.284 92.250  1.00 85.96  ? 170 CYS   R O   1 
ATOM   1127 C CB  . CYS   B 2 190 ? 99.570  102.787 92.899  1.00 78.23  ? 170 CYS   R CB  1 
ATOM   1128 S SG  . CYS   B 2 190 ? 100.806 104.084 93.052  1.00 92.59  ? 170 CYS   R SG  1 
ATOM   1129 N N   . HIS   B 2 191 ? 96.510  101.906 94.319  1.00 88.64  ? 171 HIS   R N   1 
ATOM   1130 C CA  . HIS   B 2 191 ? 95.526  100.836 94.494  1.00 92.05  ? 171 HIS   R CA  1 
ATOM   1131 C C   . HIS   B 2 191 ? 94.265  101.425 95.105  1.00 96.84  ? 171 HIS   R C   1 
ATOM   1132 O O   . HIS   B 2 191 ? 93.984  101.244 96.295  1.00 96.44  ? 171 HIS   R O   1 
ATOM   1133 C CB  . HIS   B 2 191 ? 96.090  99.708  95.359  1.00 93.32  ? 171 HIS   R CB  1 
ATOM   1134 C CG  . HIS   B 2 191 ? 97.351  99.109  94.822  1.00 93.96  ? 171 HIS   R CG  1 
ATOM   1135 N ND1 . HIS   B 2 191 ? 97.518  98.800  93.490  1.00 92.74  ? 171 HIS   R ND1 1 
ATOM   1136 C CD2 . HIS   B 2 191 ? 98.509  98.768  95.435  1.00 92.88  ? 171 HIS   R CD2 1 
ATOM   1137 C CE1 . HIS   B 2 191 ? 98.724  98.293  93.307  1.00 90.07  ? 171 HIS   R CE1 1 
ATOM   1138 N NE2 . HIS   B 2 191 ? 99.346  98.265  94.471  1.00 89.59  ? 171 HIS   R NE2 1 
ATOM   1139 N N   . PRO   B 2 192 ? 93.475  102.150 94.309  1.00 101.41 ? 172 PRO   R N   1 
ATOM   1140 C CA  . PRO   B 2 192 ? 92.304  102.842 94.873  1.00 103.41 ? 172 PRO   R CA  1 
ATOM   1141 C C   . PRO   B 2 192 ? 91.203  101.907 95.337  1.00 109.43 ? 172 PRO   R C   1 
ATOM   1142 O O   . PRO   B 2 192 ? 90.582  102.159 96.378  1.00 110.96 ? 172 PRO   R O   1 
ATOM   1143 C CB  . PRO   B 2 192 ? 91.837  103.724 93.710  1.00 107.63 ? 172 PRO   R CB  1 
ATOM   1144 C CG  . PRO   B 2 192 ? 92.311  103.010 92.494  1.00 108.98 ? 172 PRO   R CG  1 
ATOM   1145 C CD  . PRO   B 2 192 ? 93.617  102.385 92.864  1.00 102.36 ? 172 PRO   R CD  1 
ATOM   1146 N N   . VAL   B 2 193 ? 90.941  100.835 94.584  1.00 112.34 ? 173 VAL   R N   1 
ATOM   1147 C CA  . VAL   B 2 193 ? 89.869  99.905  94.937  1.00 117.07 ? 173 VAL   R CA  1 
ATOM   1148 C C   . VAL   B 2 193 ? 90.194  99.185  96.238  1.00 117.84 ? 173 VAL   R C   1 
ATOM   1149 O O   . VAL   B 2 193 ? 89.344  99.053  97.127  1.00 117.21 ? 173 VAL   R O   1 
ATOM   1150 C CB  . VAL   B 2 193 ? 89.626  98.908  93.790  1.00 113.53 ? 173 VAL   R CB  1 
ATOM   1151 N N   . LYS   B 2 194 ? 91.432  98.708  96.370  1.00 111.53 ? 174 LYS   R N   1 
ATOM   1152 C CA  . LYS   B 2 194 ? 91.836  98.054  97.607  1.00 106.88 ? 174 LYS   R CA  1 
ATOM   1153 C C   . LYS   B 2 194 ? 91.922  99.051  98.756  1.00 109.49 ? 174 LYS   R C   1 
ATOM   1154 O O   . LYS   B 2 194 ? 91.514  98.743  99.881  1.00 112.87 ? 174 LYS   R O   1 
ATOM   1155 C CB  . LYS   B 2 194 ? 93.171  97.340  97.405  1.00 102.64 ? 174 LYS   R CB  1 
ATOM   1156 N N   . ALA   B 2 195 ? 92.435  100.255 98.488  1.00 108.34 ? 175 ALA   R N   1 
ATOM   1157 C CA  . ALA   B 2 195 ? 92.620  101.243 99.549  1.00 104.66 ? 175 ALA   R CA  1 
ATOM   1158 C C   . ALA   B 2 195 ? 91.289  101.745 100.086 1.00 108.91 ? 175 ALA   R C   1 
ATOM   1159 O O   . ALA   B 2 195 ? 91.200  102.166 101.244 1.00 106.74 ? 175 ALA   R O   1 
ATOM   1160 C CB  . ALA   B 2 195 ? 93.457  102.412 99.045  1.00 98.62  ? 175 ALA   R CB  1 
ATOM   1161 N N   . LEU   B 2 196 ? 90.247  101.733 99.255  1.00 113.18 ? 176 LEU   R N   1 
ATOM   1162 C CA  . LEU   B 2 196 ? 88.912  102.014 99.767  1.00 117.72 ? 176 LEU   R CA  1 
ATOM   1163 C C   . LEU   B 2 196 ? 88.450  100.956 100.762 1.00 124.77 ? 176 LEU   R C   1 
ATOM   1164 O O   . LEU   B 2 196 ? 87.660  101.268 101.660 1.00 126.37 ? 176 LEU   R O   1 
ATOM   1165 C CB  . LEU   B 2 196 ? 87.915  102.119 98.612  1.00 108.14 ? 176 LEU   R CB  1 
ATOM   1166 N N   . ASP   B 2 197 ? 88.927  99.715  100.625 1.00 123.17 ? 177 ASP   R N   1 
ATOM   1167 C CA  . ASP   B 2 197 ? 88.495  98.645  101.517 1.00 118.64 ? 177 ASP   R CA  1 
ATOM   1168 C C   . ASP   B 2 197 ? 89.078  98.807  102.917 1.00 118.89 ? 177 ASP   R C   1 
ATOM   1169 O O   . ASP   B 2 197 ? 88.343  98.793  103.910 1.00 121.38 ? 177 ASP   R O   1 
ATOM   1170 C CB  . ASP   B 2 197 ? 88.883  97.288  100.929 1.00 112.34 ? 177 ASP   R CB  1 
ATOM   1171 N N   . PHE   B 2 198 ? 90.402  98.969  103.019 1.00 119.43 ? 178 PHE   R N   1 
ATOM   1172 C CA  . PHE   B 2 198 ? 91.109  98.924  104.305 1.00 116.05 ? 178 PHE   R CA  1 
ATOM   1173 C C   . PHE   B 2 198 ? 91.991  100.166 104.482 1.00 113.55 ? 178 PHE   R C   1 
ATOM   1174 O O   . PHE   B 2 198 ? 93.212  100.145 104.349 1.00 110.16 ? 178 PHE   R O   1 
ATOM   1175 C CB  . PHE   B 2 198 ? 91.892  97.557  104.446 1.00 115.59 ? 178 PHE   R CB  1 
ATOM   1176 C CG  . PHE   B 2 198 ? 92.882  97.256  103.327 1.00 118.97 ? 178 PHE   R CG  1 
ATOM   1177 C CD1 . PHE   B 2 198 ? 92.448  96.663  102.148 1.00 119.38 ? 178 PHE   R CD1 1 
ATOM   1178 C CD2 . PHE   B 2 198 ? 94.245  97.442  103.496 1.00 115.27 ? 178 PHE   R CD2 1 
ATOM   1179 C CE1 . PHE   B 2 198 ? 93.336  96.358  101.134 1.00 116.39 ? 178 PHE   R CE1 1 
ATOM   1180 C CE2 . PHE   B 2 198 ? 95.135  97.140  102.483 1.00 114.13 ? 178 PHE   R CE2 1 
ATOM   1181 C CZ  . PHE   B 2 198 ? 94.680  96.593  101.305 1.00 112.72 ? 178 PHE   R CZ  1 
ATOM   1182 N N   . ARG   B 2 199 ? 91.344  101.282 104.816 1.00 111.39 ? 179 ARG   R N   1 
ATOM   1183 C CA  . ARG   B 2 199 ? 92.064  102.488 105.201 1.00 103.22 ? 179 ARG   R CA  1 
ATOM   1184 C C   . ARG   B 2 199 ? 91.337  103.244 106.305 1.00 103.55 ? 179 ARG   R C   1 
ATOM   1185 O O   . ARG   B 2 199 ? 91.525  104.456 106.440 1.00 102.59 ? 179 ARG   R O   1 
ATOM   1186 C CB  . ARG   B 2 199 ? 92.287  103.402 103.999 1.00 100.75 ? 179 ARG   R CB  1 
ATOM   1187 C CG  . ARG   B 2 199 ? 93.516  103.050 103.183 1.00 97.91  ? 179 ARG   R CG  1 
ATOM   1188 C CD  . ARG   B 2 199 ? 94.083  104.277 102.499 1.00 87.71  ? 179 ARG   R CD  1 
ATOM   1189 N NE  . ARG   B 2 199 ? 94.057  105.449 103.363 1.00 80.04  ? 179 ARG   R NE  1 
ATOM   1190 C CZ  . ARG   B 2 199 ? 93.970  106.695 102.923 1.00 82.33  ? 179 ARG   R CZ  1 
ATOM   1191 N NH1 . ARG   B 2 199 ? 93.850  106.965 101.637 1.00 83.14  ? 179 ARG   R NH1 1 
ATOM   1192 N NH2 . ARG   B 2 199 ? 93.993  107.694 103.796 1.00 89.20  ? 179 ARG   R NH2 1 
ATOM   1193 N N   . THR   B 2 200 ? 90.499  102.565 107.078 1.00 105.45 ? 180 THR   R N   1 
ATOM   1194 C CA  . THR   B 2 200 ? 89.779  103.202 108.163 1.00 108.94 ? 180 THR   R CA  1 
ATOM   1195 C C   . THR   B 2 200 ? 90.760  103.612 109.259 1.00 102.69 ? 180 THR   R C   1 
ATOM   1196 O O   . THR   B 2 200 ? 91.873  103.090 109.334 1.00 99.13  ? 180 THR   R O   1 
ATOM   1197 C CB  . THR   B 2 200 ? 88.717  102.245 108.711 1.00 109.71 ? 180 THR   R CB  1 
ATOM   1198 O OG1 . THR   B 2 200 ? 87.806  102.937 109.575 1.00 104.67 ? 180 THR   R OG1 1 
ATOM   1199 C CG2 . THR   B 2 200 ? 89.369  101.110 109.480 1.00 108.92 ? 180 THR   R CG2 1 
ATOM   1200 N N   . PRO   B 2 201 ? 90.376  104.562 110.119 1.00 101.83 ? 181 PRO   R N   1 
ATOM   1201 C CA  . PRO   B 2 201 ? 91.203  104.868 111.299 1.00 102.73 ? 181 PRO   R CA  1 
ATOM   1202 C C   . PRO   B 2 201 ? 91.206  103.785 112.372 1.00 104.04 ? 181 PRO   R C   1 
ATOM   1203 O O   . PRO   B 2 201 ? 91.938  103.928 113.357 1.00 99.83  ? 181 PRO   R O   1 
ATOM   1204 C CB  . PRO   B 2 201 ? 90.593  106.170 111.841 1.00 100.73 ? 181 PRO   R CB  1 
ATOM   1205 C CG  . PRO   B 2 201 ? 89.285  106.316 111.195 1.00 102.83 ? 181 PRO   R CG  1 
ATOM   1206 C CD  . PRO   B 2 201 ? 89.279  105.524 109.935 1.00 101.65 ? 181 PRO   R CD  1 
ATOM   1207 N N   . ARG   B 2 202 ? 90.405  102.725 112.240 1.00 102.00 ? 182 ARG   R N   1 
ATOM   1208 C CA  . ARG   B 2 202 ? 90.577  101.536 113.063 1.00 99.50  ? 182 ARG   R CA  1 
ATOM   1209 C C   . ARG   B 2 202 ? 91.823  100.748 112.689 1.00 92.49  ? 182 ARG   R C   1 
ATOM   1210 O O   . ARG   B 2 202 ? 92.453  100.153 113.568 1.00 93.01  ? 182 ARG   R O   1 
ATOM   1211 C CB  . ARG   B 2 202 ? 89.348  100.630 112.953 1.00 96.20  ? 182 ARG   R CB  1 
ATOM   1212 N N   . ASN   B 2 203 ? 92.191  100.720 111.407 1.00 88.19  ? 183 ASN   R N   1 
ATOM   1213 C CA  . ASN   B 2 203 ? 93.398  100.008 111.002 1.00 92.26  ? 183 ASN   R CA  1 
ATOM   1214 C C   . ASN   B 2 203 ? 94.658  100.746 111.438 1.00 95.51  ? 183 ASN   R C   1 
ATOM   1215 O O   . ASN   B 2 203 ? 95.665  100.114 111.789 1.00 93.13  ? 183 ASN   R O   1 
ATOM   1216 C CB  . ASN   B 2 203 ? 93.404  99.807  109.489 1.00 99.16  ? 183 ASN   R CB  1 
ATOM   1217 C CG  . ASN   B 2 203 ? 94.470  98.824  109.030 1.00 116.55 ? 183 ASN   R CG  1 
ATOM   1218 O OD1 . ASN   B 2 203 ? 95.176  98.228  109.841 1.00 112.35 ? 183 ASN   R OD1 1 
ATOM   1219 N ND2 . ASN   B 2 203 ? 94.598  98.663  107.720 1.00 126.55 ? 183 ASN   R ND2 1 
ATOM   1220 N N   . ALA   B 2 204 ? 94.625  102.081 111.407 1.00 98.26  ? 184 ALA   R N   1 
ATOM   1221 C CA  . ALA   B 2 204 ? 95.822  102.868 111.693 1.00 91.73  ? 184 ALA   R CA  1 
ATOM   1222 C C   . ALA   B 2 204 ? 96.251  102.721 113.145 1.00 82.81  ? 184 ALA   R C   1 
ATOM   1223 O O   . ALA   B 2 204 ? 97.448  102.729 113.445 1.00 75.13  ? 184 ALA   R O   1 
ATOM   1224 C CB  . ALA   B 2 204 ? 95.582  104.338 111.351 1.00 87.40  ? 184 ALA   R CB  1 
ATOM   1225 N N   . LYS   B 2 205 ? 95.288  102.585 114.056 1.00 80.88  ? 185 LYS   R N   1 
ATOM   1226 C CA  . LYS   B 2 205 ? 95.612  102.375 115.462 1.00 78.30  ? 185 LYS   R CA  1 
ATOM   1227 C C   . LYS   B 2 205 ? 96.338  101.053 115.667 1.00 79.91  ? 185 LYS   R C   1 
ATOM   1228 O O   . LYS   B 2 205 ? 97.313  100.974 116.424 1.00 82.31  ? 185 LYS   R O   1 
ATOM   1229 C CB  . LYS   B 2 205 ? 94.335  102.426 116.296 1.00 78.03  ? 185 LYS   R CB  1 
ATOM   1230 N N   . ILE   B 2 206 ? 95.883  100.002 114.986 1.00 81.02  ? 186 ILE   R N   1 
ATOM   1231 C CA  . ILE   B 2 206 ? 96.525  98.699  115.116 1.00 79.86  ? 186 ILE   R CA  1 
ATOM   1232 C C   . ILE   B 2 206 ? 97.916  98.717  114.491 1.00 86.38  ? 186 ILE   R C   1 
ATOM   1233 O O   . ILE   B 2 206 ? 98.856  98.113  115.024 1.00 88.82  ? 186 ILE   R O   1 
ATOM   1234 C CB  . ILE   B 2 206 ? 95.633  97.602  114.515 1.00 71.74  ? 186 ILE   R CB  1 
ATOM   1235 C CG1 . ILE   B 2 206 ? 94.368  97.445  115.351 1.00 71.24  ? 186 ILE   R CG1 1 
ATOM   1236 C CG2 . ILE   B 2 206 ? 96.365  96.296  114.475 1.00 77.61  ? 186 ILE   R CG2 1 
ATOM   1237 C CD1 . ILE   B 2 206 ? 93.364  96.505  114.761 1.00 73.10  ? 186 ILE   R CD1 1 
ATOM   1238 N N   . VAL   B 2 207 ? 98.082  99.423  113.367 1.00 86.37  ? 187 VAL   R N   1 
ATOM   1239 C CA  . VAL   B 2 207 ? 99.418  99.548  112.780 1.00 86.15  ? 187 VAL   R CA  1 
ATOM   1240 C C   . VAL   B 2 207 ? 100.344 100.352 113.688 1.00 85.84  ? 187 VAL   R C   1 
ATOM   1241 O O   . VAL   B 2 207 ? 101.533 100.035 113.812 1.00 82.59  ? 187 VAL   R O   1 
ATOM   1242 C CB  . VAL   B 2 207 ? 99.345  100.158 111.372 1.00 83.34  ? 187 VAL   R CB  1 
ATOM   1243 C CG1 . VAL   B 2 207 ? 100.708 100.083 110.711 1.00 77.73  ? 187 VAL   R CG1 1 
ATOM   1244 C CG2 . VAL   B 2 207 ? 98.328  99.411  110.543 1.00 89.98  ? 187 VAL   R CG2 1 
ATOM   1245 N N   . ASN   B 2 208 ? 99.820  101.402 114.332 1.00 85.22  ? 188 ASN   R N   1 
ATOM   1246 C CA  . ASN   B 2 208 ? 100.626 102.198 115.256 1.00 82.20  ? 188 ASN   R CA  1 
ATOM   1247 C C   . ASN   B 2 208 ? 101.070 101.382 116.459 1.00 82.08  ? 188 ASN   R C   1 
ATOM   1248 O O   . ASN   B 2 208 ? 102.229 101.469 116.879 1.00 82.63  ? 188 ASN   R O   1 
ATOM   1249 C CB  . ASN   B 2 208 ? 99.846  103.423 115.724 1.00 76.24  ? 188 ASN   R CB  1 
ATOM   1250 C CG  . ASN   B 2 208 ? 99.970  104.586 114.778 1.00 78.04  ? 188 ASN   R CG  1 
ATOM   1251 O OD1 . ASN   B 2 208 ? 100.444 104.438 113.653 1.00 81.99  ? 188 ASN   R OD1 1 
ATOM   1252 N ND2 . ASN   B 2 208 ? 99.545  105.758 115.228 1.00 73.43  ? 188 ASN   R ND2 1 
ATOM   1253 N N   . VAL   B 2 209 ? 100.167 100.580 117.028 1.00 78.31  ? 189 VAL   R N   1 
ATOM   1254 C CA  . VAL   B 2 209 ? 100.546 99.773  118.184 1.00 71.47  ? 189 VAL   R CA  1 
ATOM   1255 C C   . VAL   B 2 209 ? 101.533 98.683  117.785 1.00 72.92  ? 189 VAL   R C   1 
ATOM   1256 O O   . VAL   B 2 209 ? 102.470 98.387  118.533 1.00 76.48  ? 189 VAL   R O   1 
ATOM   1257 C CB  . VAL   B 2 209 ? 99.305  99.202  118.893 1.00 73.37  ? 189 VAL   R CB  1 
ATOM   1258 C CG1 . VAL   B 2 209 ? 98.554  98.239  118.017 1.00 75.37  ? 189 VAL   R CG1 1 
ATOM   1259 C CG2 . VAL   B 2 209 ? 99.733  98.496  120.156 1.00 72.96  ? 189 VAL   R CG2 1 
ATOM   1260 N N   . CYS   B 2 210 ? 101.365 98.091  116.595 1.00 77.31  ? 190 CYS   R N   1 
ATOM   1261 C CA  . CYS   B 2 210 ? 102.319 97.081  116.138 1.00 86.11  ? 190 CYS   R CA  1 
ATOM   1262 C C   . CYS   B 2 210 ? 103.697 97.685  115.891 1.00 85.94  ? 190 CYS   R C   1 
ATOM   1263 O O   . CYS   B 2 210 ? 104.721 97.090  116.257 1.00 87.13  ? 190 CYS   R O   1 
ATOM   1264 C CB  . CYS   B 2 210 ? 101.799 96.400  114.875 1.00 86.54  ? 190 CYS   R CB  1 
ATOM   1265 S SG  . CYS   B 2 210 ? 103.006 95.327  114.060 1.00 107.75 ? 190 CYS   R SG  1 
ATOM   1266 N N   . ASN   B 2 211 ? 103.738 98.876  115.288 1.00 83.10  ? 191 ASN   R N   1 
ATOM   1267 C CA  . ASN   B 2 211 ? 104.996 99.586  115.078 1.00 87.02  ? 191 ASN   R CA  1 
ATOM   1268 C C   . ASN   B 2 211 ? 105.664 99.927  116.404 1.00 83.53  ? 191 ASN   R C   1 
ATOM   1269 O O   . ASN   B 2 211 ? 106.886 99.790  116.556 1.00 82.24  ? 191 ASN   R O   1 
ATOM   1270 C CB  . ASN   B 2 211 ? 104.727 100.857 114.272 1.00 90.48  ? 191 ASN   R CB  1 
ATOM   1271 C CG  . ASN   B 2 211 ? 105.990 101.529 113.787 1.00 89.64  ? 191 ASN   R CG  1 
ATOM   1272 O OD1 . ASN   B 2 211 ? 107.097 101.045 114.008 1.00 89.37  ? 191 ASN   R OD1 1 
ATOM   1273 N ND2 . ASN   B 2 211 ? 105.827 102.661 113.114 1.00 80.63  ? 191 ASN   R ND2 1 
ATOM   1274 N N   . TRP   B 2 212 ? 104.874 100.363 117.381 1.00 81.00  ? 192 TRP   R N   1 
ATOM   1275 C CA  . TRP   B 2 212 ? 105.469 100.799 118.633 1.00 80.81  ? 192 TRP   R CA  1 
ATOM   1276 C C   . TRP   B 2 212 ? 105.984 99.598  119.422 1.00 76.42  ? 192 TRP   R C   1 
ATOM   1277 O O   . TRP   B 2 212 ? 107.024 99.685  120.079 1.00 80.72  ? 192 TRP   R O   1 
ATOM   1278 C CB  . TRP   B 2 212 ? 104.451 101.591 119.449 1.00 82.43  ? 192 TRP   R CB  1 
ATOM   1279 C CG  . TRP   B 2 212 ? 105.058 102.278 120.598 1.00 82.23  ? 192 TRP   R CG  1 
ATOM   1280 C CD1 . TRP   B 2 212 ? 105.077 101.867 121.889 1.00 89.69  ? 192 TRP   R CD1 1 
ATOM   1281 C CD2 . TRP   B 2 212 ? 105.670 103.570 120.576 1.00 88.64  ? 192 TRP   R CD2 1 
ATOM   1282 N NE1 . TRP   B 2 212 ? 105.718 102.798 122.673 1.00 101.16 ? 192 TRP   R NE1 1 
ATOM   1283 C CE2 . TRP   B 2 212 ? 106.086 103.858 121.886 1.00 98.42  ? 192 TRP   R CE2 1 
ATOM   1284 C CE3 . TRP   B 2 212 ? 105.926 104.503 119.568 1.00 83.36  ? 192 TRP   R CE3 1 
ATOM   1285 C CZ2 . TRP   B 2 212 ? 106.741 105.043 122.219 1.00 91.56  ? 192 TRP   R CZ2 1 
ATOM   1286 C CZ3 . TRP   B 2 212 ? 106.577 105.677 119.898 1.00 82.94  ? 192 TRP   R CZ3 1 
ATOM   1287 C CH2 . TRP   B 2 212 ? 106.977 105.937 121.211 1.00 87.07  ? 192 TRP   R CH2 1 
ATOM   1288 N N   . ILE   B 2 213 ? 105.287 98.459  119.340 1.00 73.70  ? 193 ILE   R N   1 
ATOM   1289 C CA  . ILE   B 2 213 ? 105.761 97.236  119.990 1.00 70.03  ? 193 ILE   R CA  1 
ATOM   1290 C C   . ILE   B 2 213 ? 107.054 96.749  119.349 1.00 74.57  ? 193 ILE   R C   1 
ATOM   1291 O O   . ILE   B 2 213 ? 107.990 96.324  120.044 1.00 79.41  ? 193 ILE   R O   1 
ATOM   1292 C CB  . ILE   B 2 213 ? 104.682 96.142  119.940 1.00 69.40  ? 193 ILE   R CB  1 
ATOM   1293 C CG1 . ILE   B 2 213 ? 103.444 96.558  120.725 1.00 75.47  ? 193 ILE   R CG1 1 
ATOM   1294 C CG2 . ILE   B 2 213 ? 105.228 94.847  120.477 1.00 73.85  ? 193 ILE   R CG2 1 
ATOM   1295 C CD1 . ILE   B 2 213 ? 102.279 95.615  120.544 1.00 72.98  ? 193 ILE   R CD1 1 
ATOM   1296 N N   . LEU   B 2 214 ? 107.113 96.778  118.011 1.00 72.16  ? 194 LEU   R N   1 
ATOM   1297 C CA  . LEU   B 2 214 ? 108.308 96.327  117.303 1.00 75.44  ? 194 LEU   R CA  1 
ATOM   1298 C C   . LEU   B 2 214 ? 109.511 97.198  117.639 1.00 81.43  ? 194 LEU   R C   1 
ATOM   1299 O O   . LEU   B 2 214 ? 110.625 96.696  117.819 1.00 82.82  ? 194 LEU   R O   1 
ATOM   1300 C CB  . LEU   B 2 214 ? 108.061 96.331  115.799 1.00 77.02  ? 194 LEU   R CB  1 
ATOM   1301 C CG  . LEU   B 2 214 ? 109.240 95.821  114.974 1.00 80.79  ? 194 LEU   R CG  1 
ATOM   1302 C CD1 . LEU   B 2 214 ? 109.354 94.308  115.092 1.00 74.56  ? 194 LEU   R CD1 1 
ATOM   1303 C CD2 . LEU   B 2 214 ? 109.143 96.254  113.518 1.00 78.77  ? 194 LEU   R CD2 1 
ATOM   1304 N N   . SER   B 2 215 ? 109.303 98.511  117.726 1.00 76.77  ? 195 SER   R N   1 
ATOM   1305 C CA  . SER   B 2 215 ? 110.376 99.397  118.159 1.00 67.40  ? 195 SER   R CA  1 
ATOM   1306 C C   . SER   B 2 215 ? 110.775 99.132  119.607 1.00 71.47  ? 195 SER   R C   1 
ATOM   1307 O O   . SER   B 2 215 ? 111.966 99.130  119.942 1.00 69.91  ? 195 SER   R O   1 
ATOM   1308 C CB  . SER   B 2 215 ? 109.941 100.845 117.980 1.00 66.04  ? 195 SER   R CB  1 
ATOM   1309 O OG  . SER   B 2 215 ? 111.040 101.711 118.118 1.00 64.52  ? 195 SER   R OG  1 
ATOM   1310 N N   . SER   B 2 216 ? 109.788 98.905  120.484 1.00 81.51  ? 196 SER   R N   1 
ATOM   1311 C CA  . SER   B 2 216 ? 110.056 98.791  121.915 1.00 77.68  ? 196 SER   R CA  1 
ATOM   1312 C C   . SER   B 2 216 ? 110.818 97.524  122.253 1.00 75.30  ? 196 SER   R C   1 
ATOM   1313 O O   . SER   B 2 216 ? 111.558 97.502  123.245 1.00 76.09  ? 196 SER   R O   1 
ATOM   1314 C CB  . SER   B 2 216 ? 108.751 98.844  122.707 1.00 78.04  ? 196 SER   R CB  1 
ATOM   1315 O OG  . SER   B 2 216 ? 108.118 100.103 122.562 1.00 79.29  ? 196 SER   R OG  1 
ATOM   1316 N N   . ALA   B 2 217 ? 110.658 96.476  121.437 1.00 76.49  ? 197 ALA   R N   1 
ATOM   1317 C CA  . ALA   B 2 217 ? 111.396 95.231  121.655 1.00 85.21  ? 197 ALA   R CA  1 
ATOM   1318 C C   . ALA   B 2 217 ? 112.909 95.437  121.584 1.00 81.06  ? 197 ALA   R C   1 
ATOM   1319 O O   . ALA   B 2 217 ? 113.669 94.754  122.276 1.00 81.18  ? 197 ALA   R O   1 
ATOM   1320 C CB  . ALA   B 2 217 ? 110.958 94.177  120.635 1.00 83.45  ? 197 ALA   R CB  1 
ATOM   1321 N N   . ILE   B 2 218 ? 113.360 96.379  120.765 1.00 79.99  ? 198 ILE   R N   1 
ATOM   1322 C CA  . ILE   B 2 218 ? 114.770 96.723  120.674 1.00 78.82  ? 198 ILE   R CA  1 
ATOM   1323 C C   . ILE   B 2 218 ? 115.126 97.872  121.608 1.00 69.89  ? 198 ILE   R C   1 
ATOM   1324 O O   . ILE   B 2 218 ? 116.248 97.948  122.105 1.00 72.37  ? 198 ILE   R O   1 
ATOM   1325 C CB  . ILE   B 2 218 ? 115.144 97.057  119.211 1.00 92.99  ? 198 ILE   R CB  1 
ATOM   1326 C CG1 . ILE   B 2 218 ? 114.975 95.827  118.316 1.00 92.14  ? 198 ILE   R CG1 1 
ATOM   1327 C CG2 . ILE   B 2 218 ? 116.573 97.582  119.117 1.00 85.03  ? 198 ILE   R CG2 1 
ATOM   1328 C CD1 . ILE   B 2 218 ? 113.632 95.754  117.616 1.00 81.90  ? 198 ILE   R CD1 1 
ATOM   1329 N N   . GLY   B 2 219 ? 114.188 98.774  121.862 1.00 71.73  ? 199 GLY   R N   1 
ATOM   1330 C CA  . GLY   B 2 219 ? 114.494 99.916  122.699 1.00 71.46  ? 199 GLY   R CA  1 
ATOM   1331 C C   . GLY   B 2 219 ? 114.464 99.653  124.191 1.00 71.31  ? 199 GLY   R C   1 
ATOM   1332 O O   . GLY   B 2 219 ? 114.854 100.521 124.974 1.00 71.69  ? 199 GLY   R O   1 
ATOM   1333 N N   . LEU   B 2 220 ? 113.988 98.479  124.606 1.00 71.71  ? 200 LEU   R N   1 
ATOM   1334 C CA  . LEU   B 2 220 ? 113.983 98.140  126.029 1.00 73.32  ? 200 LEU   R CA  1 
ATOM   1335 C C   . LEU   B 2 220 ? 115.313 97.584  126.549 1.00 72.98  ? 200 LEU   R C   1 
ATOM   1336 O O   . LEU   B 2 220 ? 115.692 97.895  127.689 1.00 75.57  ? 200 LEU   R O   1 
ATOM   1337 C CB  . LEU   B 2 220 ? 112.860 97.156  126.344 1.00 75.06  ? 200 LEU   R CB  1 
ATOM   1338 C CG  . LEU   B 2 220 ? 112.859 96.833  127.833 1.00 79.14  ? 200 LEU   R CG  1 
ATOM   1339 C CD1 . LEU   B 2 220 ? 112.093 97.920  128.562 1.00 79.59  ? 200 LEU   R CD1 1 
ATOM   1340 C CD2 . LEU   B 2 220 ? 112.272 95.463  128.116 1.00 82.84  ? 200 LEU   R CD2 1 
ATOM   1341 N N   . PRO   B 2 221 ? 116.034 96.740  125.791 1.00 66.10  ? 201 PRO   R N   1 
ATOM   1342 C CA  . PRO   B 2 221 ? 117.397 96.362  126.210 1.00 60.71  ? 201 PRO   R CA  1 
ATOM   1343 C C   . PRO   B 2 221 ? 118.358 97.524  126.413 1.00 63.01  ? 201 PRO   R C   1 
ATOM   1344 O O   . PRO   B 2 221 ? 119.314 97.388  127.184 1.00 67.21  ? 201 PRO   R O   1 
ATOM   1345 C CB  . PRO   B 2 221 ? 117.875 95.460  125.067 1.00 59.33  ? 201 PRO   R CB  1 
ATOM   1346 C CG  . PRO   B 2 221 ? 116.665 95.016  124.359 1.00 60.41  ? 201 PRO   R CG  1 
ATOM   1347 C CD  . PRO   B 2 221 ? 115.472 95.733  124.877 1.00 66.70  ? 201 PRO   R CD  1 
ATOM   1348 N N   . VAL   B 2 222 ? 118.153 98.653  125.735 1.00 59.82  ? 202 VAL   R N   1 
ATOM   1349 C CA  . VAL   B 2 222 ? 118.964 99.834  126.000 1.00 62.25  ? 202 VAL   R CA  1 
ATOM   1350 C C   . VAL   B 2 222 ? 118.710 100.357 127.407 1.00 72.02  ? 202 VAL   R C   1 
ATOM   1351 O O   . VAL   B 2 222 ? 119.634 100.823 128.082 1.00 76.71  ? 202 VAL   R O   1 
ATOM   1352 C CB  . VAL   B 2 222 ? 118.699 100.908 124.937 1.00 56.65  ? 202 VAL   R CB  1 
ATOM   1353 C CG1 . VAL   B 2 222 ? 119.385 102.179 125.322 1.00 59.90  ? 202 VAL   R CG1 1 
ATOM   1354 C CG2 . VAL   B 2 222 ? 119.204 100.438 123.604 1.00 58.86  ? 202 VAL   R CG2 1 
ATOM   1355 N N   . MET   B 2 223 ? 117.458 100.307 127.872 1.00 70.64  ? 203 MET   R N   1 
ATOM   1356 C CA  . MET   B 2 223 ? 117.173 100.640 129.264 1.00 70.24  ? 203 MET   R CA  1 
ATOM   1357 C C   . MET   B 2 223 ? 117.618 99.542  130.218 1.00 71.45  ? 203 MET   R C   1 
ATOM   1358 O O   . MET   B 2 223 ? 117.766 99.801  131.416 1.00 75.83  ? 203 MET   R O   1 
ATOM   1359 C CB  . MET   B 2 223 ? 115.683 100.910 129.456 1.00 66.86  ? 203 MET   R CB  1 
ATOM   1360 N N   . PHE   B 2 224 ? 117.818 98.324  129.710 1.00 74.41  ? 204 PHE   R N   1 
ATOM   1361 C CA  . PHE   B 2 224 ? 118.362 97.243  130.529 1.00 76.11  ? 204 PHE   R CA  1 
ATOM   1362 C C   . PHE   B 2 224 ? 119.765 97.573  131.022 1.00 71.45  ? 204 PHE   R C   1 
ATOM   1363 O O   . PHE   B 2 224 ? 120.121 97.252  132.160 1.00 70.45  ? 204 PHE   R O   1 
ATOM   1364 C CB  . PHE   B 2 224 ? 118.376 95.943  129.717 1.00 80.04  ? 204 PHE   R CB  1 
ATOM   1365 C CG  . PHE   B 2 224 ? 118.383 94.681  130.547 1.00 86.53  ? 204 PHE   R CG  1 
ATOM   1366 C CD1 . PHE   B 2 224 ? 119.541 94.231  131.157 1.00 85.36  ? 204 PHE   R CD1 1 
ATOM   1367 C CD2 . PHE   B 2 224 ? 117.228 93.930  130.687 1.00 82.90  ? 204 PHE   R CD2 1 
ATOM   1368 C CE1 . PHE   B 2 224 ? 119.542 93.073  131.902 1.00 85.97  ? 204 PHE   R CE1 1 
ATOM   1369 C CE2 . PHE   B 2 224 ? 117.225 92.770  131.434 1.00 82.13  ? 204 PHE   R CE2 1 
ATOM   1370 C CZ  . PHE   B 2 224 ? 118.383 92.342  132.040 1.00 87.29  ? 204 PHE   R CZ  1 
ATOM   1371 N N   . MET   B 2 225 ? 120.573 98.212  130.181 1.00 72.62  ? 205 MET   R N   1 
ATOM   1372 C CA  . MET   B 2 225 ? 122.010 98.346  130.398 1.00 78.86  ? 205 MET   R CA  1 
ATOM   1373 C C   . MET   B 2 225 ? 122.458 99.797  130.286 1.00 82.32  ? 205 MET   R C   1 
ATOM   1374 O O   . MET   B 2 225 ? 123.527 100.103 129.758 1.00 88.52  ? 205 MET   R O   1 
ATOM   1375 C CB  . MET   B 2 225 ? 122.757 97.457  129.411 1.00 80.45  ? 205 MET   R CB  1 
ATOM   1376 C CG  . MET   B 2 225 ? 122.585 97.870  127.968 1.00 83.57  ? 205 MET   R CG  1 
ATOM   1377 S SD  . MET   B 2 225 ? 123.427 96.782  126.816 1.00 99.35  ? 205 MET   R SD  1 
ATOM   1378 C CE  . MET   B 2 225 ? 122.984 97.564  125.271 1.00 80.90  ? 205 MET   R CE  1 
ATOM   1379 N N   . ALA   B 2 226 ? 121.656 100.718 130.813 1.00 79.76  ? 206 ALA   R N   1 
ATOM   1380 C CA  . ALA   B 2 226 ? 122.025 102.125 130.903 1.00 75.37  ? 206 ALA   R CA  1 
ATOM   1381 C C   . ALA   B 2 226 ? 122.008 102.536 132.364 1.00 71.43  ? 206 ALA   R C   1 
ATOM   1382 O O   . ALA   B 2 226 ? 121.002 102.342 133.051 1.00 73.06  ? 206 ALA   R O   1 
ATOM   1383 C CB  . ALA   B 2 226 ? 121.075 103.007 130.095 1.00 68.17  ? 206 ALA   R CB  1 
ATOM   1384 N N   . THR   B 2 227 ? 123.114 103.094 132.843 1.00 76.34  ? 207 THR   R N   1 
ATOM   1385 C CA  . THR   B 2 227 ? 123.240 103.395 134.261 1.00 83.59  ? 207 THR   R CA  1 
ATOM   1386 C C   . THR   B 2 227 ? 124.077 104.645 134.476 1.00 87.31  ? 207 THR   R C   1 
ATOM   1387 O O   . THR   B 2 227 ? 124.834 105.073 133.599 1.00 86.02  ? 207 THR   R O   1 
ATOM   1388 C CB  . THR   B 2 227 ? 123.867 102.231 135.045 1.00 91.65  ? 207 THR   R CB  1 
ATOM   1389 O OG1 . THR   B 2 227 ? 125.033 101.758 134.359 1.00 95.06  ? 207 THR   R OG1 1 
ATOM   1390 C CG2 . THR   B 2 227 ? 122.872 101.097 135.232 1.00 90.66  ? 207 THR   R CG2 1 
ATOM   1391 N N   . THR   B 2 228 ? 123.925 105.224 135.664 1.00 91.38  ? 208 THR   R N   1 
ATOM   1392 C CA  . THR   B 2 228 ? 124.746 106.346 136.092 1.00 92.88  ? 208 THR   R CA  1 
ATOM   1393 C C   . THR   B 2 228 ? 126.017 105.824 136.760 1.00 89.85  ? 208 THR   R C   1 
ATOM   1394 O O   . THR   B 2 228 ? 125.959 104.966 137.647 1.00 89.47  ? 208 THR   R O   1 
ATOM   1395 C CB  . THR   B 2 228 ? 123.943 107.265 137.016 1.00 95.40  ? 208 THR   R CB  1 
ATOM   1396 O OG1 . THR   B 2 228 ? 124.697 108.447 137.302 1.00 99.20  ? 208 THR   R OG1 1 
ATOM   1397 C CG2 . THR   B 2 228 ? 123.531 106.576 138.310 1.00 98.56  ? 208 THR   R CG2 1 
ATOM   1398 N N   . LYS   B 2 229 ? 127.166 106.295 136.293 1.00 86.84  ? 209 LYS   R N   1 
ATOM   1399 C CA  . LYS   B 2 229 ? 128.451 105.829 136.782 1.00 90.13  ? 209 LYS   R CA  1 
ATOM   1400 C C   . LYS   B 2 229 ? 128.937 106.742 137.902 1.00 92.38  ? 209 LYS   R C   1 
ATOM   1401 O O   . LYS   B 2 229 ? 128.183 107.550 138.448 1.00 95.84  ? 209 LYS   R O   1 
ATOM   1402 C CB  . LYS   B 2 229 ? 129.457 105.758 135.636 1.00 91.12  ? 209 LYS   R CB  1 
ATOM   1403 N N   . TYR   B 2 230 ? 130.207 106.602 138.272 1.00 89.28  ? 210 TYR   R N   1 
ATOM   1404 C CA  . TYR   B 2 230 ? 130.852 107.503 139.225 1.00 93.44  ? 210 TYR   R CA  1 
ATOM   1405 C C   . TYR   B 2 230 ? 132.244 107.802 138.683 1.00 96.25  ? 210 TYR   R C   1 
ATOM   1406 O O   . TYR   B 2 230 ? 133.215 107.140 139.057 1.00 99.58  ? 210 TYR   R O   1 
ATOM   1407 C CB  . TYR   B 2 230 ? 130.915 106.889 140.618 1.00 94.82  ? 210 TYR   R CB  1 
ATOM   1408 N N   . ARG   B 2 231 ? 132.340 108.807 137.819 1.00 101.12 ? 211 ARG   R N   1 
ATOM   1409 C CA  . ARG   B 2 231 ? 133.603 109.134 137.179 1.00 103.89 ? 211 ARG   R CA  1 
ATOM   1410 C C   . ARG   B 2 231 ? 134.525 109.843 138.168 1.00 112.24 ? 211 ARG   R C   1 
ATOM   1411 O O   . ARG   B 2 231 ? 134.202 110.020 139.346 1.00 111.30 ? 211 ARG   R O   1 
ATOM   1412 C CB  . ARG   B 2 231 ? 133.365 109.989 135.937 1.00 97.60  ? 211 ARG   R CB  1 
ATOM   1413 N N   . GLN   B 2 232 ? 135.702 110.243 137.680 1.00 118.95 ? 212 GLN   R N   1 
ATOM   1414 C CA  . GLN   B 2 232 ? 136.679 110.895 138.545 1.00 120.91 ? 212 GLN   R CA  1 
ATOM   1415 C C   . GLN   B 2 232 ? 136.193 112.269 138.990 1.00 119.05 ? 212 GLN   R C   1 
ATOM   1416 O O   . GLN   B 2 232 ? 136.273 112.616 140.174 1.00 113.92 ? 212 GLN   R O   1 
ATOM   1417 C CB  . GLN   B 2 232 ? 138.022 111.007 137.823 1.00 116.15 ? 212 GLN   R CB  1 
ATOM   1418 N N   . GLY   B 2 233 ? 135.682 113.062 138.053 1.00 121.03 ? 213 GLY   R N   1 
ATOM   1419 C CA  . GLY   B 2 233 ? 135.229 114.403 138.364 1.00 119.91 ? 213 GLY   R CA  1 
ATOM   1420 C C   . GLY   B 2 233 ? 133.744 114.522 138.641 1.00 116.65 ? 213 GLY   R C   1 
ATOM   1421 O O   . GLY   B 2 233 ? 133.342 115.076 139.668 1.00 113.68 ? 213 GLY   R O   1 
ATOM   1422 N N   . SER   B 2 234 ? 132.918 114.007 137.732 1.00 113.88 ? 214 SER   R N   1 
ATOM   1423 C CA  . SER   B 2 234 ? 131.476 114.174 137.819 1.00 105.09 ? 214 SER   R CA  1 
ATOM   1424 C C   . SER   B 2 234 ? 130.775 112.907 137.353 1.00 101.85 ? 214 SER   R C   1 
ATOM   1425 O O   . SER   B 2 234 ? 131.248 112.212 136.452 1.00 102.70 ? 214 SER   R O   1 
ATOM   1426 C CB  . SER   B 2 234 ? 131.011 115.368 136.982 1.00 99.67  ? 214 SER   R CB  1 
ATOM   1427 N N   . ILE   B 2 235 ? 129.625 112.628 137.965 1.00 97.53  ? 215 ILE   R N   1 
ATOM   1428 C CA  . ILE   B 2 235 ? 128.850 111.437 137.631 1.00 93.11  ? 215 ILE   R CA  1 
ATOM   1429 C C   . ILE   B 2 235 ? 128.142 111.662 136.302 1.00 92.94  ? 215 ILE   R C   1 
ATOM   1430 O O   . ILE   B 2 235 ? 127.590 112.738 136.051 1.00 98.13  ? 215 ILE   R O   1 
ATOM   1431 C CB  . ILE   B 2 235 ? 127.853 111.106 138.746 1.00 87.72  ? 215 ILE   R CB  1 
ATOM   1432 C CG1 . ILE   B 2 235 ? 126.887 112.260 138.971 1.00 83.19  ? 215 ILE   R CG1 1 
ATOM   1433 C CG2 . ILE   B 2 235 ? 128.588 110.838 140.038 1.00 89.99  ? 215 ILE   R CG2 1 
ATOM   1434 C CD1 . ILE   B 2 235 ? 125.748 111.907 139.892 1.00 82.10  ? 215 ILE   R CD1 1 
ATOM   1435 N N   . ASP   B 2 236 ? 128.169 110.654 135.436 1.00 85.56  ? 216 ASP   R N   1 
ATOM   1436 C CA  . ASP   B 2 236 ? 127.564 110.751 134.117 1.00 80.47  ? 216 ASP   R CA  1 
ATOM   1437 C C   . ASP   B 2 236 ? 126.800 109.477 133.782 1.00 83.04  ? 216 ASP   R C   1 
ATOM   1438 O O   . ASP   B 2 236 ? 127.063 108.405 134.326 1.00 88.37  ? 216 ASP   R O   1 
ATOM   1439 C CB  . ASP   B 2 236 ? 128.630 111.021 133.050 1.00 78.81  ? 216 ASP   R CB  1 
ATOM   1440 N N   . CYS   B 2 237 ? 125.852 109.602 132.857 1.00 80.53  ? 217 CYS   R N   1 
ATOM   1441 C CA  . CYS   B 2 237 ? 125.092 108.473 132.335 1.00 81.63  ? 217 CYS   R CA  1 
ATOM   1442 C C   . CYS   B 2 237 ? 125.891 107.758 131.263 1.00 81.39  ? 217 CYS   R C   1 
ATOM   1443 O O   . CYS   B 2 237 ? 126.666 108.388 130.540 1.00 91.07  ? 217 CYS   R O   1 
ATOM   1444 C CB  . CYS   B 2 237 ? 123.756 108.913 131.748 1.00 78.23  ? 217 CYS   R CB  1 
ATOM   1445 S SG  . CYS   B 2 237 ? 122.547 109.393 132.939 1.00 98.20  ? 217 CYS   R SG  1 
ATOM   1446 N N   . THR   B 2 238 ? 125.690 106.451 131.149 1.00 73.71  ? 218 THR   R N   1 
ATOM   1447 C CA  . THR   B 2 238 ? 126.456 105.716 130.161 1.00 73.93  ? 218 THR   R CA  1 
ATOM   1448 C C   . THR   B 2 238 ? 125.799 104.370 129.915 1.00 80.12  ? 218 THR   R C   1 
ATOM   1449 O O   . THR   B 2 238 ? 125.075 103.845 130.766 1.00 86.69  ? 218 THR   R O   1 
ATOM   1450 C CB  . THR   B 2 238 ? 127.902 105.533 130.621 1.00 78.88  ? 218 THR   R CB  1 
ATOM   1451 O OG1 . THR   B 2 238 ? 128.674 104.953 129.566 1.00 93.19  ? 218 THR   R OG1 1 
ATOM   1452 C CG2 . THR   B 2 238 ? 127.953 104.630 131.835 1.00 75.98  ? 218 THR   R CG2 1 
ATOM   1453 N N   . LEU   B 2 239 ? 126.071 103.817 128.736 1.00 81.49  ? 219 LEU   R N   1 
ATOM   1454 C CA  . LEU   B 2 239 ? 125.707 102.440 128.434 1.00 81.63  ? 219 LEU   R CA  1 
ATOM   1455 C C   . LEU   B 2 239 ? 126.854 101.522 128.837 1.00 88.36  ? 219 LEU   R C   1 
ATOM   1456 O O   . LEU   B 2 239 ? 127.971 101.653 128.329 1.00 87.59  ? 219 LEU   R O   1 
ATOM   1457 C CB  . LEU   B 2 239 ? 125.386 102.272 126.952 1.00 75.63  ? 219 LEU   R CB  1 
ATOM   1458 C CG  . LEU   B 2 239 ? 124.204 103.060 126.402 1.00 71.57  ? 219 LEU   R CG  1 
ATOM   1459 C CD1 . LEU   B 2 239 ? 123.737 102.444 125.099 1.00 69.11  ? 219 LEU   R CD1 1 
ATOM   1460 C CD2 . LEU   B 2 239 ? 123.086 103.101 127.415 1.00 63.86  ? 219 LEU   R CD2 1 
ATOM   1461 N N   . THR   B 2 240 ? 126.579 100.602 129.752 1.00 91.25  ? 220 THR   R N   1 
ATOM   1462 C CA  . THR   B 2 240 ? 127.575 99.659  130.246 1.00 93.38  ? 220 THR   R CA  1 
ATOM   1463 C C   . THR   B 2 240 ? 127.357 98.333  129.532 1.00 100.23 ? 220 THR   R C   1 
ATOM   1464 O O   . THR   B 2 240 ? 126.462 97.565  129.888 1.00 103.05 ? 220 THR   R O   1 
ATOM   1465 C CB  . THR   B 2 240 ? 127.467 99.499  131.758 1.00 93.72  ? 220 THR   R CB  1 
ATOM   1466 N N   . PHE   B 2 241 ? 128.175 98.067  128.520 1.00 101.22 ? 221 PHE   R N   1 
ATOM   1467 C CA  . PHE   B 2 241 ? 128.091 96.803  127.804 1.00 102.73 ? 221 PHE   R CA  1 
ATOM   1468 C C   . PHE   B 2 241 ? 128.690 95.690  128.657 1.00 111.43 ? 221 PHE   R C   1 
ATOM   1469 O O   . PHE   B 2 241 ? 129.841 95.780  129.093 1.00 112.45 ? 221 PHE   R O   1 
ATOM   1470 C CB  . PHE   B 2 241 ? 128.799 96.928  126.461 1.00 97.52  ? 221 PHE   R CB  1 
ATOM   1471 C CG  . PHE   B 2 241 ? 128.023 97.728  125.455 1.00 92.95  ? 221 PHE   R CG  1 
ATOM   1472 C CD1 . PHE   B 2 241 ? 126.813 97.272  124.973 1.00 90.98  ? 221 PHE   R CD1 1 
ATOM   1473 C CD2 . PHE   B 2 241 ? 128.482 98.955  125.025 1.00 94.60  ? 221 PHE   R CD2 1 
ATOM   1474 C CE1 . PHE   B 2 241 ? 126.096 98.007  124.060 1.00 83.87  ? 221 PHE   R CE1 1 
ATOM   1475 C CE2 . PHE   B 2 241 ? 127.762 99.695  124.116 1.00 92.48  ? 221 PHE   R CE2 1 
ATOM   1476 C CZ  . PHE   B 2 241 ? 126.570 99.219  123.636 1.00 86.99  ? 221 PHE   R CZ  1 
ATOM   1477 N N   . SER   B 2 242 ? 127.893 94.653  128.919 1.00 116.41 ? 222 SER   R N   1 
ATOM   1478 C CA  . SER   B 2 242 ? 128.148 93.765  130.048 1.00 123.11 ? 222 SER   R CA  1 
ATOM   1479 C C   . SER   B 2 242 ? 129.419 92.922  129.981 1.00 132.18 ? 222 SER   R C   1 
ATOM   1480 O O   . SER   B 2 242 ? 130.389 93.211  130.688 1.00 127.65 ? 222 SER   R O   1 
ATOM   1481 C CB  . SER   B 2 242 ? 126.951 92.827  130.223 1.00 122.57 ? 222 SER   R CB  1 
ATOM   1482 N N   . HIS   B 2 243 ? 129.438 91.882  129.142 1.00 139.34 ? 223 HIS   R N   1 
ATOM   1483 C CA  . HIS   B 2 243 ? 130.539 90.936  129.298 1.00 140.61 ? 223 HIS   R CA  1 
ATOM   1484 C C   . HIS   B 2 243 ? 131.816 91.390  128.580 1.00 134.31 ? 223 HIS   R C   1 
ATOM   1485 O O   . HIS   B 2 243 ? 132.823 91.634  129.256 1.00 128.64 ? 223 HIS   R O   1 
ATOM   1486 C CB  . HIS   B 2 243 ? 130.108 89.524  128.861 1.00 144.85 ? 223 HIS   R CB  1 
ATOM   1487 C CG  . HIS   B 2 243 ? 129.333 88.765  129.893 1.00 145.55 ? 223 HIS   R CG  1 
ATOM   1488 N ND1 . HIS   B 2 243 ? 129.793 88.566  131.177 1.00 148.42 ? 223 HIS   R ND1 1 
ATOM   1489 C CD2 . HIS   B 2 243 ? 128.128 88.152  129.826 1.00 143.00 ? 223 HIS   R CD2 1 
ATOM   1490 C CE1 . HIS   B 2 243 ? 128.904 87.863  131.856 1.00 151.14 ? 223 HIS   R CE1 1 
ATOM   1491 N NE2 . HIS   B 2 243 ? 127.884 87.599  131.059 1.00 147.99 ? 223 HIS   R NE2 1 
ATOM   1492 N N   . PRO   B 2 244 ? 131.851 91.529  127.224 1.00 131.39 ? 224 PRO   R N   1 
ATOM   1493 C CA  . PRO   B 2 244 ? 133.144 91.807  126.587 1.00 128.28 ? 224 PRO   R CA  1 
ATOM   1494 C C   . PRO   B 2 244 ? 133.393 93.289  126.368 1.00 131.57 ? 224 PRO   R C   1 
ATOM   1495 O O   . PRO   B 2 244 ? 134.539 93.702  126.174 1.00 130.68 ? 224 PRO   R O   1 
ATOM   1496 C CB  . PRO   B 2 244 ? 133.023 91.078  125.248 1.00 121.20 ? 224 PRO   R CB  1 
ATOM   1497 C CG  . PRO   B 2 244 ? 131.604 91.264  124.919 1.00 122.60 ? 224 PRO   R CG  1 
ATOM   1498 C CD  . PRO   B 2 244 ? 130.834 91.228  126.199 1.00 126.60 ? 224 PRO   R CD  1 
ATOM   1499 N N   . THR   B 2 245 ? 132.309 94.072  126.330 1.00 126.44 ? 225 THR   R N   1 
ATOM   1500 C CA  . THR   B 2 245 ? 132.222 95.516  126.076 1.00 119.71 ? 225 THR   R CA  1 
ATOM   1501 C C   . THR   B 2 245 ? 132.955 95.975  124.811 1.00 117.57 ? 225 THR   R C   1 
ATOM   1502 O O   . THR   B 2 245 ? 133.320 97.152  124.714 1.00 115.34 ? 225 THR   R O   1 
ATOM   1503 C CB  . THR   B 2 245 ? 132.669 96.376  127.282 1.00 116.69 ? 225 THR   R CB  1 
ATOM   1504 O OG1 . THR   B 2 245 ? 132.377 97.749  127.006 1.00 115.46 ? 225 THR   R OG1 1 
ATOM   1505 C CG2 . THR   B 2 245 ? 134.157 96.300  127.555 1.00 110.46 ? 225 THR   R CG2 1 
ATOM   1506 N N   . TRP   B 2 246 ? 133.174 95.093  123.832 1.00 113.52 ? 226 TRP   R N   1 
ATOM   1507 C CA  . TRP   B 2 246 ? 133.769 95.480  122.558 1.00 109.78 ? 226 TRP   R CA  1 
ATOM   1508 C C   . TRP   B 2 246 ? 132.909 94.954  121.421 1.00 105.01 ? 226 TRP   R C   1 
ATOM   1509 O O   . TRP   B 2 246 ? 132.871 95.528  120.330 1.00 104.90 ? 226 TRP   R O   1 
ATOM   1510 C CB  . TRP   B 2 246 ? 135.201 94.945  122.428 1.00 117.08 ? 226 TRP   R CB  1 
ATOM   1511 C CG  . TRP   B 2 246 ? 135.319 93.434  122.420 1.00 119.51 ? 226 TRP   R CG  1 
ATOM   1512 C CD1 . TRP   B 2 246 ? 135.505 92.619  123.494 1.00 117.43 ? 226 TRP   R CD1 1 
ATOM   1513 C CD2 . TRP   B 2 246 ? 135.285 92.579  121.273 1.00 118.76 ? 226 TRP   R CD2 1 
ATOM   1514 N NE1 . TRP   B 2 246 ? 135.567 91.309  123.095 1.00 117.09 ? 226 TRP   R NE1 1 
ATOM   1515 C CE2 . TRP   B 2 246 ? 135.438 91.258  121.733 1.00 120.00 ? 226 TRP   R CE2 1 
ATOM   1516 C CE3 . TRP   B 2 246 ? 135.130 92.803  119.902 1.00 116.98 ? 226 TRP   R CE3 1 
ATOM   1517 C CZ2 . TRP   B 2 246 ? 135.445 90.166  120.872 1.00 122.58 ? 226 TRP   R CZ2 1 
ATOM   1518 C CZ3 . TRP   B 2 246 ? 135.137 91.719  119.047 1.00 118.49 ? 226 TRP   R CZ3 1 
ATOM   1519 C CH2 . TRP   B 2 246 ? 135.294 90.416  119.535 1.00 123.96 ? 226 TRP   R CH2 1 
ATOM   1520 N N   . TYR   B 2 247 ? 132.227 93.842  121.682 1.00 102.54 ? 227 TYR   R N   1 
ATOM   1521 C CA  . TYR   B 2 247 ? 131.469 93.127  120.665 1.00 96.07  ? 227 TYR   R CA  1 
ATOM   1522 C C   . TYR   B 2 247 ? 130.044 93.653  120.578 1.00 90.03  ? 227 TYR   R C   1 
ATOM   1523 O O   . TYR   B 2 247 ? 129.553 93.962  119.486 1.00 93.46  ? 227 TYR   R O   1 
ATOM   1524 C CB  . TYR   B 2 247 ? 131.512 91.634  121.001 1.00 104.61 ? 227 TYR   R CB  1 
ATOM   1525 C CG  . TYR   B 2 247 ? 130.443 90.752  120.406 1.00 105.33 ? 227 TYR   R CG  1 
ATOM   1526 C CD1 . TYR   B 2 247 ? 130.555 90.262  119.115 1.00 107.38 ? 227 TYR   R CD1 1 
ATOM   1527 C CD2 . TYR   B 2 247 ? 129.342 90.370  121.159 1.00 101.89 ? 227 TYR   R CD2 1 
ATOM   1528 C CE1 . TYR   B 2 247 ? 129.588 89.444  118.581 1.00 105.26 ? 227 TYR   R CE1 1 
ATOM   1529 C CE2 . TYR   B 2 247 ? 128.371 89.551  120.634 1.00 102.18 ? 227 TYR   R CE2 1 
ATOM   1530 C CZ  . TYR   B 2 247 ? 128.499 89.092  119.345 1.00 104.97 ? 227 TYR   R CZ  1 
ATOM   1531 O OH  . TYR   B 2 247 ? 127.532 88.273  118.815 1.00 108.13 ? 227 TYR   R OH  1 
ATOM   1532 N N   . TRP   B 2 248 ? 129.389 93.807  121.729 1.00 90.44  ? 228 TRP   R N   1 
ATOM   1533 C CA  . TRP   B 2 248 ? 128.005 94.265  121.754 1.00 92.62  ? 228 TRP   R CA  1 
ATOM   1534 C C   . TRP   B 2 248 ? 127.879 95.706  121.277 1.00 88.21  ? 228 TRP   R C   1 
ATOM   1535 O O   . TRP   B 2 248 ? 126.860 96.080  120.683 1.00 84.63  ? 228 TRP   R O   1 
ATOM   1536 C CB  . TRP   B 2 248 ? 127.437 94.113  123.163 1.00 95.70  ? 228 TRP   R CB  1 
ATOM   1537 C CG  . TRP   B 2 248 ? 127.271 92.687  123.570 1.00 101.54 ? 228 TRP   R CG  1 
ATOM   1538 C CD1 . TRP   B 2 248 ? 128.133 91.942  124.314 1.00 104.41 ? 228 TRP   R CD1 1 
ATOM   1539 C CD2 . TRP   B 2 248 ? 126.176 91.828  123.244 1.00 105.04 ? 228 TRP   R CD2 1 
ATOM   1540 N NE1 . TRP   B 2 248 ? 127.644 90.670  124.476 1.00 102.35 ? 228 TRP   R NE1 1 
ATOM   1541 C CE2 . TRP   B 2 248 ? 126.442 90.575  123.827 1.00 105.37 ? 228 TRP   R CE2 1 
ATOM   1542 C CE3 . TRP   B 2 248 ? 124.997 91.996  122.515 1.00 106.52 ? 228 TRP   R CE3 1 
ATOM   1543 C CZ2 . TRP   B 2 248 ? 125.572 89.501  123.707 1.00 108.57 ? 228 TRP   R CZ2 1 
ATOM   1544 C CZ3 . TRP   B 2 248 ? 124.137 90.930  122.394 1.00 111.49 ? 228 TRP   R CZ3 1 
ATOM   1545 C CH2 . TRP   B 2 248 ? 124.427 89.697  122.987 1.00 110.94 ? 228 TRP   R CH2 1 
ATOM   1546 N N   . GLU   B 2 249 ? 128.905 96.525  121.521 1.00 86.85  ? 229 GLU   R N   1 
ATOM   1547 C CA  . GLU   B 2 249 ? 128.881 97.923  121.094 1.00 81.42  ? 229 GLU   R CA  1 
ATOM   1548 C C   . GLU   B 2 249 ? 128.826 98.030  119.578 1.00 75.18  ? 229 GLU   R C   1 
ATOM   1549 O O   . GLU   B 2 249 ? 127.951 98.704  119.012 1.00 78.47  ? 229 GLU   R O   1 
ATOM   1550 C CB  . GLU   B 2 249 ? 130.117 98.637  121.637 1.00 86.56  ? 229 GLU   R CB  1 
ATOM   1551 C CG  . GLU   B 2 249 ? 130.039 100.144 121.666 1.00 86.17  ? 229 GLU   R CG  1 
ATOM   1552 C CD  . GLU   B 2 249 ? 131.023 100.739 122.652 1.00 103.22 ? 229 GLU   R CD  1 
ATOM   1553 O OE1 . GLU   B 2 249 ? 131.931 100.008 123.098 1.00 100.56 ? 229 GLU   R OE1 1 
ATOM   1554 O OE2 . GLU   B 2 249 ? 130.886 101.931 122.991 1.00 114.15 ? 229 GLU   R OE2 1 
ATOM   1555 N N   . ASN   B 2 250 ? 129.740 97.341  118.902 1.00 75.09  ? 230 ASN   R N   1 
ATOM   1556 C CA  . ASN   B 2 250 ? 129.748 97.354  117.449 1.00 75.86  ? 230 ASN   R CA  1 
ATOM   1557 C C   . ASN   B 2 250 ? 128.527 96.645  116.885 1.00 73.27  ? 230 ASN   R C   1 
ATOM   1558 O O   . ASN   B 2 250 ? 128.044 97.020  115.810 1.00 71.14  ? 230 ASN   R O   1 
ATOM   1559 C CB  . ASN   B 2 250 ? 131.040 96.726  116.935 1.00 78.26  ? 230 ASN   R CB  1 
ATOM   1560 C CG  . ASN   B 2 250 ? 132.202 97.703  116.946 1.00 82.62  ? 230 ASN   R CG  1 
ATOM   1561 O OD1 . ASN   B 2 250 ? 132.269 98.611  116.123 1.00 87.51  ? 230 ASN   R OD1 1 
ATOM   1562 N ND2 . ASN   B 2 250 ? 133.116 97.525  117.889 1.00 73.00  ? 230 ASN   R ND2 1 
ATOM   1563 N N   . LEU   B 2 251 ? 128.000 95.647  117.602 1.00 78.11  ? 231 LEU   R N   1 
ATOM   1564 C CA  . LEU   B 2 251 ? 126.778 94.978  117.163 1.00 73.50  ? 231 LEU   R CA  1 
ATOM   1565 C C   . LEU   B 2 251 ? 125.597 95.937  117.151 1.00 68.80  ? 231 LEU   R C   1 
ATOM   1566 O O   . LEU   B 2 251 ? 124.827 95.976  116.186 1.00 64.45  ? 231 LEU   R O   1 
ATOM   1567 C CB  . LEU   B 2 251 ? 126.476 93.791  118.068 1.00 70.94  ? 231 LEU   R CB  1 
ATOM   1568 C CG  . LEU   B 2 251 ? 125.778 92.652  117.346 1.00 72.66  ? 231 LEU   R CG  1 
ATOM   1569 C CD1 . LEU   B 2 251 ? 126.707 92.121  116.277 1.00 76.95  ? 231 LEU   R CD1 1 
ATOM   1570 C CD2 . LEU   B 2 251 ? 125.385 91.568  118.318 1.00 81.81  ? 231 LEU   R CD2 1 
ATOM   1571 N N   . LEU   B 2 252 ? 125.450 96.729  118.216 1.00 70.13  ? 232 LEU   R N   1 
ATOM   1572 C CA  . LEU   B 2 252 ? 124.373 97.713  118.277 1.00 65.72  ? 232 LEU   R CA  1 
ATOM   1573 C C   . LEU   B 2 252 ? 124.537 98.782  117.203 1.00 65.18  ? 232 LEU   R C   1 
ATOM   1574 O O   . LEU   B 2 252 ? 123.548 99.201  116.587 1.00 61.07  ? 232 LEU   R O   1 
ATOM   1575 C CB  . LEU   B 2 252 ? 124.322 98.349  119.667 1.00 61.89  ? 232 LEU   R CB  1 
ATOM   1576 C CG  . LEU   B 2 252 ? 123.039 99.031  120.148 1.00 54.82  ? 232 LEU   R CG  1 
ATOM   1577 C CD1 . LEU   B 2 252 ? 123.100 99.207  121.644 1.00 62.39  ? 232 LEU   R CD1 1 
ATOM   1578 C CD2 . LEU   B 2 252 ? 122.804 100.375 119.497 1.00 53.82  ? 232 LEU   R CD2 1 
ATOM   1579 N N   . LYS   B 2 253 ? 125.773 99.244  116.975 1.00 68.80  ? 233 LYS   R N   1 
ATOM   1580 C CA  . LYS   B 2 253 ? 126.007 100.282 115.970 1.00 62.02  ? 233 LYS   R CA  1 
ATOM   1581 C C   . LYS   B 2 253 ? 125.653 99.791  114.570 1.00 59.02  ? 233 LYS   R C   1 
ATOM   1582 O O   . LYS   B 2 253 ? 124.924 100.466 113.824 1.00 58.21  ? 233 LYS   R O   1 
ATOM   1583 C CB  . LYS   B 2 253 ? 127.463 100.738 116.023 1.00 61.43  ? 233 LYS   R CB  1 
ATOM   1584 C CG  . LYS   B 2 253 ? 127.742 101.831 117.035 1.00 64.06  ? 233 LYS   R CG  1 
ATOM   1585 C CD  . LYS   B 2 253 ? 129.218 102.167 117.071 1.00 69.73  ? 233 LYS   R CD  1 
ATOM   1586 C CE  . LYS   B 2 253 ? 129.478 103.451 117.828 1.00 64.98  ? 233 LYS   R CE  1 
ATOM   1587 N NZ  . LYS   B 2 253 ? 130.907 103.852 117.752 1.00 57.78  ? 233 LYS   R NZ  1 
ATOM   1588 N N   . ILE   B 2 254 ? 126.127 98.592  114.215 1.00 59.31  ? 234 ILE   R N   1 
ATOM   1589 C CA  . ILE   B 2 254 ? 125.852 98.025  112.898 1.00 58.46  ? 234 ILE   R CA  1 
ATOM   1590 C C   . ILE   B 2 254 ? 124.368 97.729  112.737 1.00 61.89  ? 234 ILE   R C   1 
ATOM   1591 O O   . ILE   B 2 254 ? 123.795 97.948  111.663 1.00 59.61  ? 234 ILE   R O   1 
ATOM   1592 C CB  . ILE   B 2 254 ? 126.697 96.761  112.673 1.00 59.56  ? 234 ILE   R CB  1 
ATOM   1593 C CG1 . ILE   B 2 254 ? 128.167 97.124  112.492 1.00 58.39  ? 234 ILE   R CG1 1 
ATOM   1594 C CG2 . ILE   B 2 254 ? 126.185 96.003  111.477 1.00 58.04  ? 234 ILE   R CG2 1 
ATOM   1595 C CD1 . ILE   B 2 254 ? 129.082 95.931  112.517 1.00 58.46  ? 234 ILE   R CD1 1 
ATOM   1596 N N   . CYS   B 2 255 ? 123.722 97.231  113.799 1.00 64.58  ? 235 CYS   R N   1 
ATOM   1597 C CA  . CYS   B 2 255 ? 122.301 96.903  113.732 1.00 61.04  ? 235 CYS   R CA  1 
ATOM   1598 C C   . CYS   B 2 255 ? 121.449 98.144  113.517 1.00 57.60  ? 235 CYS   R C   1 
ATOM   1599 O O   . CYS   B 2 255 ? 120.546 98.144  112.671 1.00 60.71  ? 235 CYS   R O   1 
ATOM   1600 C CB  . CYS   B 2 255 ? 121.872 96.183  115.007 1.00 63.67  ? 235 CYS   R CB  1 
ATOM   1601 S SG  . CYS   B 2 255 ? 120.116 95.837  115.088 1.00 84.57  ? 235 CYS   R SG  1 
ATOM   1602 N N   . VAL   B 2 256 ? 121.735 99.218  114.262 1.00 58.77  ? 236 VAL   R N   1 
ATOM   1603 C CA  . VAL   B 2 256 ? 120.956 100.447 114.134 1.00 57.83  ? 236 VAL   R CA  1 
ATOM   1604 C C   . VAL   B 2 256 ? 121.141 101.055 112.753 1.00 53.62  ? 236 VAL   R C   1 
ATOM   1605 O O   . VAL   B 2 256 ? 120.169 101.466 112.114 1.00 54.19  ? 236 VAL   R O   1 
ATOM   1606 C CB  . VAL   B 2 256 ? 121.330 101.451 115.236 1.00 57.89  ? 236 VAL   R CB  1 
ATOM   1607 C CG1 . VAL   B 2 256 ? 120.813 102.822 114.872 1.00 52.85  ? 236 VAL   R CG1 1 
ATOM   1608 C CG2 . VAL   B 2 256 ? 120.767 101.009 116.562 1.00 57.18  ? 236 VAL   R CG2 1 
ATOM   1609 N N   . PHE   B 2 257 ? 122.381 101.078 112.252 1.00 55.30  ? 237 PHE   R N   1 
ATOM   1610 C CA  . PHE   B 2 257 ? 122.635 101.666 110.938 1.00 56.70  ? 237 PHE   R CA  1 
ATOM   1611 C C   . PHE   B 2 257 ? 121.960 100.865 109.824 1.00 56.97  ? 237 PHE   R C   1 
ATOM   1612 O O   . PHE   B 2 257 ? 121.191 101.427 109.027 1.00 59.23  ? 237 PHE   R O   1 
ATOM   1613 C CB  . PHE   B 2 257 ? 124.142 101.779 110.712 1.00 58.04  ? 237 PHE   R CB  1 
ATOM   1614 C CG  . PHE   B 2 257 ? 124.527 102.208 109.331 1.00 56.22  ? 237 PHE   R CG  1 
ATOM   1615 C CD1 . PHE   B 2 257 ? 124.065 103.398 108.811 1.00 55.97  ? 237 PHE   R CD1 1 
ATOM   1616 C CD2 . PHE   B 2 257 ? 125.401 101.452 108.577 1.00 56.45  ? 237 PHE   R CD2 1 
ATOM   1617 C CE1 . PHE   B 2 257 ? 124.436 103.804 107.552 1.00 57.76  ? 237 PHE   R CE1 1 
ATOM   1618 C CE2 . PHE   B 2 257 ? 125.775 101.858 107.322 1.00 57.01  ? 237 PHE   R CE2 1 
ATOM   1619 C CZ  . PHE   B 2 257 ? 125.292 103.037 106.808 1.00 55.53  ? 237 PHE   R CZ  1 
ATOM   1620 N N   . ILE   B 2 258 ? 122.170 99.536  109.818 1.00 57.91  ? 238 ILE   R N   1 
ATOM   1621 C CA  . ILE   B 2 258 ? 121.621 98.652  108.784 1.00 61.87  ? 238 ILE   R CA  1 
ATOM   1622 C C   . ILE   B 2 258 ? 120.103 98.692  108.771 1.00 55.90  ? 238 ILE   R C   1 
ATOM   1623 O O   . ILE   B 2 258 ? 119.488 98.916  107.725 1.00 59.10  ? 238 ILE   R O   1 
ATOM   1624 C CB  . ILE   B 2 258 ? 122.118 97.209  108.970 1.00 60.05  ? 238 ILE   R CB  1 
ATOM   1625 C CG1 . ILE   B 2 258 ? 123.591 97.078  108.591 1.00 63.13  ? 238 ILE   R CG1 1 
ATOM   1626 C CG2 . ILE   B 2 258 ? 121.262 96.258  108.164 1.00 54.23  ? 238 ILE   R CG2 1 
ATOM   1627 C CD1 . ILE   B 2 258 ? 123.861 97.336  107.128 1.00 54.54  ? 238 ILE   R CD1 1 
ATOM   1628 N N   . PHE   B 2 259 ? 119.474 98.523  109.933 1.00 52.62  ? 239 PHE   R N   1 
ATOM   1629 C CA  . PHE   B 2 259 ? 118.020 98.533  109.944 1.00 55.78  ? 239 PHE   R CA  1 
ATOM   1630 C C   . PHE   B 2 259 ? 117.484 99.929  109.659 1.00 61.06  ? 239 PHE   R C   1 
ATOM   1631 O O   . PHE   B 2 259 ? 116.906 100.130 108.584 1.00 69.86  ? 239 PHE   R O   1 
ATOM   1632 C CB  . PHE   B 2 259 ? 117.494 97.979  111.263 1.00 56.68  ? 239 PHE   R CB  1 
ATOM   1633 C CG  . PHE   B 2 259 ? 117.502 96.480  111.310 1.00 60.18  ? 239 PHE   R CG  1 
ATOM   1634 C CD1 . PHE   B 2 259 ? 116.524 95.746  110.667 1.00 63.89  ? 239 PHE   R CD1 1 
ATOM   1635 C CD2 . PHE   B 2 259 ? 118.518 95.804  111.961 1.00 60.69  ? 239 PHE   R CD2 1 
ATOM   1636 C CE1 . PHE   B 2 259 ? 116.549 94.371  110.692 1.00 69.29  ? 239 PHE   R CE1 1 
ATOM   1637 C CE2 . PHE   B 2 259 ? 118.545 94.429  111.990 1.00 58.98  ? 239 PHE   R CE2 1 
ATOM   1638 C CZ  . PHE   B 2 259 ? 117.561 93.713  111.356 1.00 63.40  ? 239 PHE   R CZ  1 
ATOM   1639 N N   . ALA   B 2 260 ? 117.797 100.910 110.521 1.00 58.62  ? 240 ALA   R N   1 
ATOM   1640 C CA  . ALA   B 2 260 ? 117.161 102.224 110.476 1.00 57.53  ? 240 ALA   R CA  1 
ATOM   1641 C C   . ALA   B 2 260 ? 117.606 103.114 109.310 1.00 61.38  ? 240 ALA   R C   1 
ATOM   1642 O O   . ALA   B 2 260 ? 117.184 104.273 109.263 1.00 57.80  ? 240 ALA   R O   1 
ATOM   1643 C CB  . ALA   B 2 260 ? 117.390 102.961 111.793 1.00 47.51  ? 240 ALA   R CB  1 
ATOM   1644 N N   . PHE   B 2 261 ? 118.459 102.651 108.388 1.00 61.19  ? 241 PHE   R N   1 
ATOM   1645 C CA  . PHE   B 2 261 ? 118.280 103.101 107.005 1.00 57.94  ? 241 PHE   R CA  1 
ATOM   1646 C C   . PHE   B 2 261 ? 117.747 102.041 106.056 1.00 62.84  ? 241 PHE   R C   1 
ATOM   1647 O O   . PHE   B 2 261 ? 116.692 102.257 105.454 1.00 63.07  ? 241 PHE   R O   1 
ATOM   1648 C CB  . PHE   B 2 261 ? 119.517 103.695 106.337 1.00 53.23  ? 241 PHE   R CB  1 
ATOM   1649 C CG  . PHE   B 2 261 ? 119.941 104.988 106.882 1.00 57.70  ? 241 PHE   R CG  1 
ATOM   1650 C CD1 . PHE   B 2 261 ? 119.281 106.140 106.479 1.00 56.87  ? 241 PHE   R CD1 1 
ATOM   1651 C CD2 . PHE   B 2 261 ? 121.055 105.100 107.655 1.00 64.51  ? 241 PHE   R CD2 1 
ATOM   1652 C CE1 . PHE   B 2 261 ? 119.667 107.364 106.928 1.00 57.44  ? 241 PHE   R CE1 1 
ATOM   1653 C CE2 . PHE   B 2 261 ? 121.451 106.321 108.087 1.00 67.72  ? 241 PHE   R CE2 1 
ATOM   1654 C CZ  . PHE   B 2 261 ? 120.757 107.460 107.732 1.00 59.60  ? 241 PHE   R CZ  1 
ATOM   1655 N N   . ILE   B 2 262 ? 118.472 100.931 105.885 1.00 61.86  ? 242 ILE   R N   1 
ATOM   1656 C CA  . ILE   B 2 262 ? 118.360 100.148 104.661 1.00 66.76  ? 242 ILE   R CA  1 
ATOM   1657 C C   . ILE   B 2 262 ? 117.001 99.464  104.568 1.00 61.93  ? 242 ILE   R C   1 
ATOM   1658 O O   . ILE   B 2 262 ? 116.533 99.148  103.470 1.00 69.03  ? 242 ILE   R O   1 
ATOM   1659 C CB  . ILE   B 2 262 ? 119.535 99.155  104.574 1.00 76.41  ? 242 ILE   R CB  1 
ATOM   1660 C CG1 . ILE   B 2 262 ? 120.868 99.927  104.542 1.00 61.92  ? 242 ILE   R CG1 1 
ATOM   1661 C CG2 . ILE   B 2 262 ? 119.393 98.214  103.373 1.00 77.81  ? 242 ILE   R CG2 1 
ATOM   1662 C CD1 . ILE   B 2 262 ? 120.975 100.986 103.466 1.00 44.71  ? 242 ILE   R CD1 1 
ATOM   1663 N N   . MET   B 2 263 ? 116.318 99.262  105.696 1.00 55.41  ? 243 MET   R N   1 
ATOM   1664 C CA  . MET   B 2 263 ? 114.937 98.872  105.445 1.00 65.32  ? 243 MET   R CA  1 
ATOM   1665 C C   . MET   B 2 263 ? 114.064 100.082 105.082 1.00 67.63  ? 243 MET   R C   1 
ATOM   1666 O O   . MET   B 2 263 ? 113.488 100.096 103.979 1.00 69.32  ? 243 MET   R O   1 
ATOM   1667 C CB  . MET   B 2 263 ? 114.369 98.088  106.632 1.00 67.07  ? 243 MET   R CB  1 
ATOM   1668 N N   . PRO   B 2 264 ? 113.931 101.115 105.939 1.00 61.06  ? 244 PRO   R N   1 
ATOM   1669 C CA  . PRO   B 2 264 ? 112.939 102.160 105.632 1.00 62.93  ? 244 PRO   R CA  1 
ATOM   1670 C C   . PRO   B 2 264 ? 113.303 103.053 104.462 1.00 61.72  ? 244 PRO   R C   1 
ATOM   1671 O O   . PRO   B 2 264 ? 112.402 103.462 103.725 1.00 66.97  ? 244 PRO   R O   1 
ATOM   1672 C CB  . PRO   B 2 264 ? 112.836 102.970 106.932 1.00 57.94  ? 244 PRO   R CB  1 
ATOM   1673 C CG  . PRO   B 2 264 ? 113.673 102.340 107.904 1.00 54.57  ? 244 PRO   R CG  1 
ATOM   1674 C CD  . PRO   B 2 264 ? 114.495 101.291 107.285 1.00 53.73  ? 244 PRO   R CD  1 
ATOM   1675 N N   . VAL   B 2 265 ? 114.580 103.382 104.265 1.00 54.14  ? 245 VAL   R N   1 
ATOM   1676 C CA  . VAL   B 2 265 ? 114.932 104.255 103.148 1.00 54.13  ? 245 VAL   R CA  1 
ATOM   1677 C C   . VAL   B 2 265 ? 114.711 103.548 101.817 1.00 58.81  ? 245 VAL   R C   1 
ATOM   1678 O O   . VAL   B 2 265 ? 114.225 104.155 100.856 1.00 63.47  ? 245 VAL   R O   1 
ATOM   1679 C CB  . VAL   B 2 265 ? 116.371 104.769 103.286 1.00 49.60  ? 245 VAL   R CB  1 
ATOM   1680 C CG1 . VAL   B 2 265 ? 116.864 105.266 101.950 1.00 41.54  ? 245 VAL   R CG1 1 
ATOM   1681 C CG2 . VAL   B 2 265 ? 116.417 105.888 104.297 1.00 52.59  ? 245 VAL   R CG2 1 
ATOM   1682 N N   . LEU   B 2 266 ? 115.042 102.257 101.738 1.00 54.96  ? 246 LEU   R N   1 
ATOM   1683 C CA  . LEU   B 2 266 ? 114.790 101.511 100.509 1.00 57.48  ? 246 LEU   R CA  1 
ATOM   1684 C C   . LEU   B 2 266 ? 113.296 101.353 100.250 1.00 58.89  ? 246 LEU   R C   1 
ATOM   1685 O O   . LEU   B 2 266 ? 112.844 101.481 99.102  1.00 64.34  ? 246 LEU   R O   1 
ATOM   1686 C CB  . LEU   B 2 266 ? 115.477 100.148 100.565 1.00 58.20  ? 246 LEU   R CB  1 
ATOM   1687 C CG  . LEU   B 2 266 ? 116.996 100.212 100.389 1.00 60.55  ? 246 LEU   R CG  1 
ATOM   1688 C CD1 . LEU   B 2 266 ? 117.579 98.848  100.072 1.00 64.13  ? 246 LEU   R CD1 1 
ATOM   1689 C CD2 . LEU   B 2 266 ? 117.354 101.210 99.306  1.00 57.05  ? 246 LEU   R CD2 1 
ATOM   1690 N N   . ILE   B 2 267 ? 112.513 101.101 101.305 1.00 56.33  ? 247 ILE   R N   1 
ATOM   1691 C CA  . ILE   B 2 267 ? 111.063 100.982 101.143 1.00 57.48  ? 247 ILE   R CA  1 
ATOM   1692 C C   . ILE   B 2 267 ? 110.464 102.306 100.679 1.00 56.73  ? 247 ILE   R C   1 
ATOM   1693 O O   . ILE   B 2 267 ? 109.602 102.340 99.793  1.00 56.80  ? 247 ILE   R O   1 
ATOM   1694 C CB  . ILE   B 2 267 ? 110.407 100.508 102.451 1.00 55.52  ? 247 ILE   R CB  1 
ATOM   1695 C CG1 . ILE   B 2 267 ? 110.813 99.076  102.780 1.00 54.71  ? 247 ILE   R CG1 1 
ATOM   1696 C CG2 . ILE   B 2 267 ? 108.905 100.589 102.330 1.00 53.42  ? 247 ILE   R CG2 1 
ATOM   1697 C CD1 . ILE   B 2 267 ? 110.522 98.694  104.206 1.00 53.52  ? 247 ILE   R CD1 1 
ATOM   1698 N N   . ILE   B 2 268 ? 110.929 103.415 101.259 1.00 56.24  ? 248 ILE   R N   1 
ATOM   1699 C CA  . ILE   B 2 268 ? 110.405 104.735 100.918 1.00 56.14  ? 248 ILE   R CA  1 
ATOM   1700 C C   . ILE   B 2 268 ? 110.764 105.111 99.489  1.00 56.65  ? 248 ILE   R C   1 
ATOM   1701 O O   . ILE   B 2 268 ? 109.942 105.682 98.760  1.00 63.70  ? 248 ILE   R O   1 
ATOM   1702 C CB  . ILE   B 2 268 ? 110.925 105.782 101.915 1.00 51.06  ? 248 ILE   R CB  1 
ATOM   1703 C CG1 . ILE   B 2 268 ? 110.175 105.671 103.236 1.00 48.71  ? 248 ILE   R CG1 1 
ATOM   1704 C CG2 . ILE   B 2 268 ? 110.813 107.170 101.321 1.00 47.22  ? 248 ILE   R CG2 1 
ATOM   1705 C CD1 . ILE   B 2 268 ? 110.913 106.292 104.386 1.00 56.88  ? 248 ILE   R CD1 1 
ATOM   1706 N N   . THR   B 2 269 ? 111.998 104.817 99.071  1.00 53.05  ? 249 THR   R N   1 
ATOM   1707 C CA  . THR   B 2 269 ? 112.402 105.112 97.702  1.00 56.46  ? 249 THR   R CA  1 
ATOM   1708 C C   . THR   B 2 269 ? 111.594 104.306 96.695  1.00 58.78  ? 249 THR   R C   1 
ATOM   1709 O O   . THR   B 2 269 ? 111.154 104.851 95.677  1.00 60.61  ? 249 THR   R O   1 
ATOM   1710 C CB  . THR   B 2 269 ? 113.895 104.850 97.518  1.00 60.37  ? 249 THR   R CB  1 
ATOM   1711 O OG1 . THR   B 2 269 ? 114.648 105.893 98.144  1.00 59.99  ? 249 THR   R OG1 1 
ATOM   1712 C CG2 . THR   B 2 269 ? 114.242 104.809 96.045  1.00 59.67  ? 249 THR   R CG2 1 
ATOM   1713 N N   . VAL   B 2 270 ? 111.351 103.020 96.976  1.00 57.51  ? 250 VAL   R N   1 
ATOM   1714 C CA  . VAL   B 2 270 ? 110.566 102.205 96.049  1.00 58.52  ? 250 VAL   R CA  1 
ATOM   1715 C C   . VAL   B 2 270 ? 109.115 102.682 95.991  1.00 61.94  ? 250 VAL   R C   1 
ATOM   1716 O O   . VAL   B 2 270 ? 108.522 102.777 94.903  1.00 62.63  ? 250 VAL   R O   1 
ATOM   1717 C CB  . VAL   B 2 270 ? 110.656 100.719 96.430  1.00 53.98  ? 250 VAL   R CB  1 
ATOM   1718 C CG1 . VAL   B 2 270 ? 109.725 99.913  95.565  1.00 58.77  ? 250 VAL   R CG1 1 
ATOM   1719 C CG2 . VAL   B 2 270 ? 112.073 100.222 96.273  1.00 55.74  ? 250 VAL   R CG2 1 
ATOM   1720 N N   . CYS   B 2 271 ? 108.527 103.005 97.151  1.00 58.69  ? 251 CYS   R N   1 
ATOM   1721 C CA  . CYS   B 2 271 ? 107.138 103.459 97.198  1.00 56.43  ? 251 CYS   R CA  1 
ATOM   1722 C C   . CYS   B 2 271 ? 106.947 104.773 96.451  1.00 54.99  ? 251 CYS   R C   1 
ATOM   1723 O O   . CYS   B 2 271 ? 106.015 104.915 95.651  1.00 59.75  ? 251 CYS   R O   1 
ATOM   1724 C CB  . CYS   B 2 271 ? 106.683 103.607 98.648  1.00 57.27  ? 251 CYS   R CB  1 
ATOM   1725 S SG  . CYS   B 2 271 ? 106.443 102.054 99.519  1.00 86.27  ? 251 CYS   R SG  1 
ATOM   1726 N N   . TYR   B 2 272 ? 107.834 105.740 96.669  1.00 53.95  ? 252 TYR   R N   1 
ATOM   1727 C CA  . TYR   B 2 272 ? 107.656 107.000 95.963  1.00 55.51  ? 252 TYR   R CA  1 
ATOM   1728 C C   . TYR   B 2 272 ? 108.043 106.895 94.495  1.00 62.64  ? 252 TYR   R C   1 
ATOM   1729 O O   . TYR   B 2 272 ? 107.495 107.634 93.667  1.00 71.00  ? 252 TYR   R O   1 
ATOM   1730 C CB  . TYR   B 2 272 ? 108.430 108.113 96.657  1.00 53.49  ? 252 TYR   R CB  1 
ATOM   1731 C CG  . TYR   B 2 272 ? 107.548 108.869 97.613  1.00 55.35  ? 252 TYR   R CG  1 
ATOM   1732 C CD1 . TYR   B 2 272 ? 107.401 108.454 98.928  1.00 56.28  ? 252 TYR   R CD1 1 
ATOM   1733 C CD2 . TYR   B 2 272 ? 106.818 109.964 97.188  1.00 58.30  ? 252 TYR   R CD2 1 
ATOM   1734 C CE1 . TYR   B 2 272 ? 106.582 109.131 99.799  1.00 57.54  ? 252 TYR   R CE1 1 
ATOM   1735 C CE2 . TYR   B 2 272 ? 105.995 110.644 98.049  1.00 57.24  ? 252 TYR   R CE2 1 
ATOM   1736 C CZ  . TYR   B 2 272 ? 105.882 110.224 99.351  1.00 61.87  ? 252 TYR   R CZ  1 
ATOM   1737 O OH  . TYR   B 2 272 ? 105.061 110.908 100.210 1.00 68.12  ? 252 TYR   R OH  1 
ATOM   1738 N N   . GLY   B 2 273 ? 108.946 105.976 94.141  1.00 56.29  ? 253 GLY   R N   1 
ATOM   1739 C CA  . GLY   B 2 273 ? 109.231 105.748 92.736  1.00 60.78  ? 253 GLY   R CA  1 
ATOM   1740 C C   . GLY   B 2 273 ? 108.041 105.184 91.989  1.00 64.79  ? 253 GLY   R C   1 
ATOM   1741 O O   . GLY   B 2 273 ? 107.844 105.469 90.806  1.00 70.25  ? 253 GLY   R O   1 
ATOM   1742 N N   . LEU   B 2 274 ? 107.248 104.350 92.656  1.00 59.77  ? 254 LEU   R N   1 
ATOM   1743 C CA  . LEU   B 2 274 ? 106.015 103.888 92.025  1.00 62.33  ? 254 LEU   R CA  1 
ATOM   1744 C C   . LEU   B 2 274 ? 104.936 104.973 92.010  1.00 61.45  ? 254 LEU   R C   1 
ATOM   1745 O O   . LEU   B 2 274 ? 104.168 105.077 91.039  1.00 61.18  ? 254 LEU   R O   1 
ATOM   1746 C CB  . LEU   B 2 274 ? 105.503 102.633 92.724  1.00 63.24  ? 254 LEU   R CB  1 
ATOM   1747 C CG  . LEU   B 2 274 ? 106.059 101.280 92.298  1.00 61.18  ? 254 LEU   R CG  1 
ATOM   1748 C CD1 . LEU   B 2 274 ? 105.677 101.023 90.856  1.00 71.09  ? 254 LEU   R CD1 1 
ATOM   1749 C CD2 . LEU   B 2 274 ? 107.556 101.212 92.476  1.00 58.72  ? 254 LEU   R CD2 1 
ATOM   1750 N N   . MET   B 2 275 ? 104.860 105.778 93.079  1.00 60.75  ? 255 MET   R N   1 
ATOM   1751 C CA  . MET   B 2 275 ? 103.853 106.835 93.159  1.00 56.78  ? 255 MET   R CA  1 
ATOM   1752 C C   . MET   B 2 275 ? 104.044 107.865 92.059  1.00 64.56  ? 255 MET   R C   1 
ATOM   1753 O O   . MET   B 2 275 ? 103.074 108.317 91.449  1.00 73.45  ? 255 MET   R O   1 
ATOM   1754 C CB  . MET   B 2 275 ? 103.915 107.553 94.502  1.00 57.25  ? 255 MET   R CB  1 
ATOM   1755 C CG  . MET   B 2 275 ? 103.534 106.778 95.725  1.00 62.05  ? 255 MET   R CG  1 
ATOM   1756 S SD  . MET   B 2 275 ? 103.744 107.947 97.076  1.00 81.91  ? 255 MET   R SD  1 
ATOM   1757 C CE  . MET   B 2 275 ? 103.392 106.954 98.493  1.00 68.17  ? 255 MET   R CE  1 
ATOM   1758 N N   . ILE   B 2 276 ? 105.293 108.259 91.802  1.00 61.99  ? 256 ILE   R N   1 
ATOM   1759 C CA  . ILE   B 2 276 ? 105.545 109.269 90.776  1.00 65.34  ? 256 ILE   R CA  1 
ATOM   1760 C C   . ILE   B 2 276 ? 105.224 108.727 89.390  1.00 67.44  ? 256 ILE   R C   1 
ATOM   1761 O O   . ILE   B 2 276 ? 104.709 109.453 88.530  1.00 72.36  ? 256 ILE   R O   1 
ATOM   1762 C CB  . ILE   B 2 276 ? 106.992 109.779 90.866  1.00 62.20  ? 256 ILE   R CB  1 
ATOM   1763 C CG1 . ILE   B 2 276 ? 107.168 110.597 92.140  1.00 60.41  ? 256 ILE   R CG1 1 
ATOM   1764 C CG2 . ILE   B 2 276 ? 107.342 110.582 89.637  1.00 63.42  ? 256 ILE   R CG2 1 
ATOM   1765 C CD1 . ILE   B 2 276 ? 108.591 110.936 92.444  1.00 68.37  ? 256 ILE   R CD1 1 
ATOM   1766 N N   . LEU   B 2 277 ? 105.518 107.447 89.150  1.00 65.66  ? 257 LEU   R N   1 
ATOM   1767 C CA  . LEU   B 2 277 ? 105.205 106.848 87.856  1.00 68.35  ? 257 LEU   R CA  1 
ATOM   1768 C C   . LEU   B 2 277 ? 103.701 106.769 87.636  1.00 67.76  ? 257 LEU   R C   1 
ATOM   1769 O O   . LEU   B 2 277 ? 103.227 106.880 86.501  1.00 66.76  ? 257 LEU   R O   1 
ATOM   1770 C CB  . LEU   B 2 277 ? 105.841 105.464 87.745  1.00 67.01  ? 257 LEU   R CB  1 
ATOM   1771 N N   . ARG   B 2 278 ? 102.933 106.565 88.708  1.00 71.27  ? 258 ARG   R N   1 
ATOM   1772 C CA  . ARG   B 2 278 ? 101.479 106.636 88.564  1.00 71.31  ? 258 ARG   R CA  1 
ATOM   1773 C C   . ARG   B 2 278 ? 100.999 108.074 88.372  1.00 73.36  ? 258 ARG   R C   1 
ATOM   1774 O O   . ARG   B 2 278 ? 100.162 108.342 87.504  1.00 78.29  ? 258 ARG   R O   1 
ATOM   1775 C CB  . ARG   B 2 278 ? 100.793 106.001 89.771  1.00 72.36  ? 258 ARG   R CB  1 
ATOM   1776 N N   . LEU   B 2 279 ? 101.522 109.014 89.164  1.00 72.01  ? 259 LEU   R N   1 
ATOM   1777 C CA  . LEU   B 2 279 ? 101.009 110.382 89.154  1.00 75.57  ? 259 LEU   R CA  1 
ATOM   1778 C C   . LEU   B 2 279 ? 101.382 111.131 87.886  1.00 81.86  ? 259 LEU   R C   1 
ATOM   1779 O O   . LEU   B 2 279 ? 100.761 112.152 87.570  1.00 86.80  ? 259 LEU   R O   1 
ATOM   1780 C CB  . LEU   B 2 279 ? 101.513 111.153 90.374  1.00 66.04  ? 259 LEU   R CB  1 
ATOM   1781 C CG  . LEU   B 2 279 ? 100.626 111.204 91.615  1.00 59.60  ? 259 LEU   R CG  1 
ATOM   1782 C CD1 . LEU   B 2 279 ? 100.644 109.895 92.331  1.00 68.06  ? 259 LEU   R CD1 1 
ATOM   1783 C CD2 . LEU   B 2 279 ? 101.091 112.293 92.546  1.00 58.45  ? 259 LEU   R CD2 1 
ATOM   1784 N N   . LYS   B 2 280 ? 102.405 110.676 87.165  1.00 80.59  ? 260 LYS   R N   1 
ATOM   1785 C CA  . LYS   B 2 280 ? 102.792 111.380 85.948  1.00 84.43  ? 260 LYS   R CA  1 
ATOM   1786 C C   . LYS   B 2 280 ? 101.735 111.247 84.856  1.00 89.64  ? 260 LYS   R C   1 
ATOM   1787 O O   . LYS   B 2 280 ? 101.402 112.233 84.190  1.00 93.37  ? 260 LYS   R O   1 
ATOM   1788 C CB  . LYS   B 2 280 ? 104.143 110.874 85.450  1.00 81.48  ? 260 LYS   R CB  1 
ATOM   1789 C CG  . LYS   B 2 280 ? 105.319 111.391 86.248  1.00 81.85  ? 260 LYS   R CG  1 
ATOM   1790 C CD  . LYS   B 2 280 ? 106.619 110.844 85.705  1.00 82.21  ? 260 LYS   R CD  1 
ATOM   1791 C CE  . LYS   B 2 280 ? 106.549 110.679 84.203  1.00 76.99  ? 260 LYS   R CE  1 
ATOM   1792 N NZ  . LYS   B 2 280 ? 107.798 110.088 83.658  1.00 73.21  ? 260 LYS   R NZ  1 
ATOM   1793 N N   . SER   B 2 281 ? 101.189 110.049 84.659  1.00 85.56  ? 261 SER   R N   1 
ATOM   1794 C CA  . SER   B 2 281 ? 100.381 109.761 83.482  1.00 92.34  ? 261 SER   R CA  1 
ATOM   1795 C C   . SER   B 2 281 ? 98.890  109.648 83.771  1.00 92.83  ? 261 SER   R C   1 
ATOM   1796 O O   . SER   B 2 281 ? 98.131  109.253 82.882  1.00 91.91  ? 261 SER   R O   1 
ATOM   1797 C CB  . SER   B 2 281 ? 100.871 108.476 82.816  1.00 93.50  ? 261 SER   R CB  1 
ATOM   1798 N N   . VAL   B 2 282 ? 98.449  109.985 84.977  1.00 91.98  ? 262 VAL   R N   1 
ATOM   1799 C CA  . VAL   B 2 282 ? 97.057  109.814 85.378  1.00 94.18  ? 262 VAL   R CA  1 
ATOM   1800 C C   . VAL   B 2 282 ? 96.313  111.124 85.166  1.00 93.97  ? 262 VAL   R C   1 
ATOM   1801 O O   . VAL   B 2 282 ? 96.739  112.175 85.658  1.00 89.68  ? 262 VAL   R O   1 
ATOM   1802 C CB  . VAL   B 2 282 ? 96.950  109.353 86.841  1.00 88.53  ? 262 VAL   R CB  1 
ATOM   1803 N N   . ARG   B 2 283 ? 95.201  111.063 84.433  1.00 90.08  ? 263 ARG   R N   1 
ATOM   1804 C CA  . ARG   B 2 283 ? 94.355  112.239 84.274  1.00 85.24  ? 263 ARG   R CA  1 
ATOM   1805 C C   . ARG   B 2 283 ? 93.713  112.622 85.600  1.00 88.91  ? 263 ARG   R C   1 
ATOM   1806 O O   . ARG   B 2 283 ? 93.947  113.714 86.127  1.00 93.62  ? 263 ARG   R O   1 
ATOM   1807 C CB  . ARG   B 2 283 ? 93.285  111.980 83.214  1.00 83.97  ? 263 ARG   R CB  1 
ATOM   1808 C CG  . ARG   B 2 283 ? 92.345  113.157 83.009  1.00 89.02  ? 263 ARG   R CG  1 
ATOM   1809 C CD  . ARG   B 2 283 ? 91.345  112.906 81.895  1.00 90.43  ? 263 ARG   R CD  1 
ATOM   1810 N NE  . ARG   B 2 283 ? 90.478  114.059 81.682  1.00 95.91  ? 263 ARG   R NE  1 
ATOM   1811 C CZ  . ARG   B 2 283 ? 89.293  114.226 82.253  1.00 98.13  ? 263 ARG   R CZ  1 
ATOM   1812 N NH1 . ARG   B 2 283 ? 88.787  113.324 83.073  1.00 104.64 ? 263 ARG   R NH1 1 
ATOM   1813 N NH2 . ARG   B 2 283 ? 88.597  115.327 81.990  1.00 92.62  ? 263 ARG   R NH2 1 
ATOM   1814 N N   . LEU   B 2 284 ? 92.899  111.729 86.155  1.00 86.44  ? 264 LEU   R N   1 
ATOM   1815 C CA  . LEU   B 2 284 ? 92.297  111.908 87.466  1.00 85.05  ? 264 LEU   R CA  1 
ATOM   1816 C C   . LEU   B 2 284 ? 92.514  110.644 88.280  1.00 93.47  ? 264 LEU   R C   1 
ATOM   1817 O O   . LEU   B 2 284 ? 92.611  109.546 87.728  1.00 101.41 ? 264 LEU   R O   1 
ATOM   1818 C CB  . LEU   B 2 284 ? 90.804  112.211 87.372  1.00 81.09  ? 264 LEU   R CB  1 
ATOM   1819 C CG  . LEU   B 2 284 ? 90.413  113.604 86.894  1.00 79.23  ? 264 LEU   R CG  1 
ATOM   1820 C CD1 . LEU   B 2 284 ? 89.053  113.563 86.244  1.00 86.42  ? 264 LEU   R CD1 1 
ATOM   1821 C CD2 . LEU   B 2 284 ? 90.414  114.570 88.052  1.00 77.37  ? 264 LEU   R CD2 1 
ATOM   1822 N N   . LEU   B 2 285 ? 92.597  110.802 89.599  1.00 89.92  ? 265 LEU   R N   1 
ATOM   1823 C CA  . LEU   B 2 285 ? 92.886  109.655 90.451  1.00 91.84  ? 265 LEU   R CA  1 
ATOM   1824 C C   . LEU   B 2 285 ? 91.630  108.990 91.004  1.00 97.73  ? 265 LEU   R C   1 
ATOM   1825 O O   . LEU   B 2 285 ? 91.539  107.758 91.008  1.00 103.06 ? 265 LEU   R O   1 
ATOM   1826 C CB  . LEU   B 2 285 ? 93.811  110.073 91.595  1.00 80.58  ? 265 LEU   R CB  1 
ATOM   1827 C CG  . LEU   B 2 285 ? 95.197  110.474 91.099  1.00 75.72  ? 265 LEU   R CG  1 
ATOM   1828 C CD1 . LEU   B 2 285 ? 96.187  110.562 92.236  1.00 69.21  ? 265 LEU   R CD1 1 
ATOM   1829 C CD2 . LEU   B 2 285 ? 95.670  109.481 90.058  1.00 75.12  ? 265 LEU   R CD2 1 
ATOM   1830 N N   . SER   B 2 286 ? 90.656  109.765 91.474  1.00 96.27  ? 266 SER   R N   1 
ATOM   1831 C CA  . SER   B 2 286 ? 89.451  109.199 92.065  1.00 94.60  ? 266 SER   R CA  1 
ATOM   1832 C C   . SER   B 2 286 ? 88.187  109.556 91.294  1.00 95.47  ? 266 SER   R C   1 
ATOM   1833 O O   . SER   B 2 286 ? 87.082  109.313 91.791  1.00 98.05  ? 266 SER   R O   1 
ATOM   1834 C CB  . SER   B 2 286 ? 89.319  109.647 93.522  1.00 97.80  ? 266 SER   R CB  1 
ATOM   1835 N N   . GLY   B 2 287 ? 88.316  110.117 90.095  1.00 95.05  ? 267 GLY   R N   1 
ATOM   1836 C CA  . GLY   B 2 287 ? 87.176  110.467 89.276  1.00 92.58  ? 267 GLY   R CA  1 
ATOM   1837 C C   . GLY   B 2 287 ? 86.643  111.870 89.469  1.00 90.72  ? 267 GLY   R C   1 
ATOM   1838 O O   . GLY   B 2 287 ? 85.777  112.296 88.695  1.00 91.87  ? 267 GLY   R O   1 
ATOM   1839 N N   . SER   B 2 288 ? 87.129  112.602 90.464  1.00 86.92  ? 268 SER   R N   1 
ATOM   1840 C CA  . SER   B 2 288 ? 86.693  113.966 90.715  1.00 84.24  ? 268 SER   R CA  1 
ATOM   1841 C C   . SER   B 2 288 ? 87.914  114.857 90.869  1.00 83.88  ? 268 SER   R C   1 
ATOM   1842 O O   . SER   B 2 288 ? 88.926  114.439 91.436  1.00 88.31  ? 268 SER   R O   1 
ATOM   1843 C CB  . SER   B 2 288 ? 85.817  114.048 91.967  1.00 83.34  ? 268 SER   R CB  1 
ATOM   1844 N N   . ARG   B 2 289 ? 87.812  116.086 90.358  1.00 79.81  ? 269 ARG   R N   1 
ATOM   1845 C CA  . ARG   B 2 289 ? 88.953  116.997 90.373  1.00 78.24  ? 269 ARG   R CA  1 
ATOM   1846 C C   . ARG   B 2 289 ? 89.329  117.406 91.792  1.00 77.38  ? 269 ARG   R C   1 
ATOM   1847 O O   . ARG   B 2 289 ? 90.518  117.539 92.113  1.00 81.22  ? 269 ARG   R O   1 
ATOM   1848 C CB  . ARG   B 2 289 ? 88.646  118.225 89.521  1.00 74.86  ? 269 ARG   R CB  1 
ATOM   1849 C CG  . ARG   B 2 289 ? 88.534  117.922 88.044  1.00 74.45  ? 269 ARG   R CG  1 
ATOM   1850 C CD  . ARG   B 2 289 ? 87.638  118.917 87.343  1.00 83.07  ? 269 ARG   R CD  1 
ATOM   1851 N NE  . ARG   B 2 289 ? 88.096  119.196 85.989  1.00 85.59  ? 269 ARG   R NE  1 
ATOM   1852 C CZ  . ARG   B 2 289 ? 87.468  118.802 84.891  1.00 85.24  ? 269 ARG   R CZ  1 
ATOM   1853 N NH1 . ARG   B 2 289 ? 86.354  118.092 84.950  1.00 83.75  ? 269 ARG   R NH1 1 
ATOM   1854 N NH2 . ARG   B 2 289 ? 87.970  119.128 83.704  1.00 86.57  ? 269 ARG   R NH2 1 
ATOM   1855 N N   . GLU   B 2 290 ? 88.329  117.624 92.648  1.00 73.41  ? 270 GLU   R N   1 
ATOM   1856 C CA  . GLU   B 2 290 ? 88.598  117.977 94.038  1.00 80.79  ? 270 GLU   R CA  1 
ATOM   1857 C C   . GLU   B 2 290 ? 89.308  116.840 94.760  1.00 84.16  ? 270 GLU   R C   1 
ATOM   1858 O O   . GLU   B 2 290 ? 90.243  117.068 95.538  1.00 82.06  ? 270 GLU   R O   1 
ATOM   1859 C CB  . GLU   B 2 290 ? 87.293  118.338 94.747  1.00 76.81  ? 270 GLU   R CB  1 
ATOM   1860 N N   . LYS   B 2 291 ? 88.884  115.603 94.497  1.00 82.96  ? 271 LYS   R N   1 
ATOM   1861 C CA  . LYS   B 2 291 ? 89.558  114.449 95.079  1.00 82.37  ? 271 LYS   R CA  1 
ATOM   1862 C C   . LYS   B 2 291 ? 90.974  114.312 94.532  1.00 78.01  ? 271 LYS   R C   1 
ATOM   1863 O O   . LYS   B 2 291 ? 91.882  113.890 95.253  1.00 74.40  ? 271 LYS   R O   1 
ATOM   1864 C CB  . LYS   B 2 291 ? 88.737  113.187 94.825  1.00 84.58  ? 271 LYS   R CB  1 
ATOM   1865 C CG  . LYS   B 2 291 ? 87.411  113.202 95.565  1.00 87.60  ? 271 LYS   R CG  1 
ATOM   1866 C CD  . LYS   B 2 291 ? 86.530  112.015 95.224  1.00 94.76  ? 271 LYS   R CD  1 
ATOM   1867 C CE  . LYS   B 2 291 ? 87.030  110.736 95.862  1.00 99.76  ? 271 LYS   R CE  1 
ATOM   1868 N NZ  . LYS   B 2 291 ? 86.073  109.616 95.644  1.00 100.27 ? 271 LYS   R NZ  1 
ATOM   1869 N N   . ASP   B 2 292 ? 91.185  114.707 93.272  1.00 75.73  ? 272 ASP   R N   1 
ATOM   1870 C CA  . ASP   B 2 292 ? 92.528  114.736 92.693  1.00 72.27  ? 272 ASP   R CA  1 
ATOM   1871 C C   . ASP   B 2 292 ? 93.440  115.702 93.441  1.00 72.98  ? 272 ASP   R C   1 
ATOM   1872 O O   . ASP   B 2 292 ? 94.563  115.336 93.815  1.00 77.50  ? 272 ASP   R O   1 
ATOM   1873 C CB  . ASP   B 2 292 ? 92.438  115.137 91.222  1.00 73.61  ? 272 ASP   R CB  1 
ATOM   1874 C CG  . ASP   B 2 292 ? 93.736  114.938 90.468  1.00 79.68  ? 272 ASP   R CG  1 
ATOM   1875 O OD1 . ASP   B 2 292 ? 94.739  114.480 91.048  1.00 78.18  ? 272 ASP   R OD1 1 
ATOM   1876 O OD2 . ASP   B 2 292 ? 93.759  115.265 89.268  1.00 90.10  ? 272 ASP   R OD2 1 
ATOM   1877 N N   . ARG   B 2 293 ? 92.984  116.939 93.651  1.00 74.30  ? 273 ARG   R N   1 
ATOM   1878 C CA  . ARG   B 2 293 ? 93.817  117.923 94.338  1.00 74.00  ? 273 ARG   R CA  1 
ATOM   1879 C C   . ARG   B 2 293 ? 94.065  117.522 95.787  1.00 70.01  ? 273 ARG   R C   1 
ATOM   1880 O O   . ARG   B 2 293 ? 95.194  117.642 96.288  1.00 70.61  ? 273 ARG   R O   1 
ATOM   1881 C CB  . ARG   B 2 293 ? 93.171  119.305 94.263  1.00 70.54  ? 273 ARG   R CB  1 
ATOM   1882 N N   . ASN   B 2 294 ? 93.032  117.020 96.467  1.00 65.23  ? 274 ASN   R N   1 
ATOM   1883 C CA  . ASN   B 2 294 ? 93.201  116.600 97.851  1.00 67.09  ? 274 ASN   R CA  1 
ATOM   1884 C C   . ASN   B 2 294 ? 94.090  115.371 97.962  1.00 65.72  ? 274 ASN   R C   1 
ATOM   1885 O O   . ASN   B 2 294 ? 94.714  115.154 99.003  1.00 61.60  ? 274 ASN   R O   1 
ATOM   1886 C CB  . ASN   B 2 294 ? 91.840  116.331 98.490  1.00 68.83  ? 274 ASN   R CB  1 
ATOM   1887 N N   . LEU   B 2 295 ? 94.149  114.548 96.917  1.00 66.09  ? 275 LEU   R N   1 
ATOM   1888 C CA  . LEU   B 2 295 ? 94.994  113.365 96.972  1.00 62.24  ? 275 LEU   R CA  1 
ATOM   1889 C C   . LEU   B 2 295 ? 96.438  113.680 96.609  1.00 61.71  ? 275 LEU   R C   1 
ATOM   1890 O O   . LEU   B 2 295 ? 97.347  112.953 97.019  1.00 60.73  ? 275 LEU   R O   1 
ATOM   1891 C CB  . LEU   B 2 295 ? 94.425  112.289 96.053  1.00 60.87  ? 275 LEU   R CB  1 
ATOM   1892 C CG  . LEU   B 2 295 ? 95.119  110.940 96.011  1.00 66.77  ? 275 LEU   R CG  1 
ATOM   1893 C CD1 . LEU   B 2 295 ? 95.045  110.306 97.374  1.00 71.87  ? 275 LEU   R CD1 1 
ATOM   1894 C CD2 . LEU   B 2 295 ? 94.419  110.070 95.004  1.00 70.06  ? 275 LEU   R CD2 1 
ATOM   1895 N N   . ARG   B 2 296 ? 96.672  114.737 95.832  1.00 62.73  ? 276 ARG   R N   1 
ATOM   1896 C CA  . ARG   B 2 296 ? 98.041  115.098 95.476  1.00 58.50  ? 276 ARG   R CA  1 
ATOM   1897 C C   . ARG   B 2 296 ? 98.719  115.998 96.506  1.00 60.21  ? 276 ARG   R C   1 
ATOM   1898 O O   . ARG   B 2 296 ? 99.941  115.886 96.706  1.00 65.89  ? 276 ARG   R O   1 
ATOM   1899 C CB  . ARG   B 2 296 ? 98.062  115.771 94.106  1.00 61.31  ? 276 ARG   R CB  1 
ATOM   1900 C CG  . ARG   B 2 296 ? 97.833  114.800 92.967  1.00 66.41  ? 276 ARG   R CG  1 
ATOM   1901 C CD  . ARG   B 2 296 ? 97.558  115.514 91.667  1.00 73.60  ? 276 ARG   R CD  1 
ATOM   1902 N NE  . ARG   B 2 296 ? 98.350  114.970 90.573  1.00 75.08  ? 276 ARG   R NE  1 
ATOM   1903 C CZ  . ARG   B 2 296 ? 97.876  114.152 89.646  1.00 74.04  ? 276 ARG   R CZ  1 
ATOM   1904 N NH1 . ARG   B 2 296 ? 96.610  113.780 89.638  1.00 77.93  ? 276 ARG   R NH1 1 
ATOM   1905 N NH2 . ARG   B 2 296 ? 98.690  113.705 88.697  1.00 75.79  ? 276 ARG   R NH2 1 
ATOM   1906 N N   . ARG   B 2 297 ? 97.959  116.876 97.172  1.00 55.14  ? 277 ARG   R N   1 
ATOM   1907 C CA  . ARG   B 2 297 ? 98.555  117.766 98.169  1.00 54.15  ? 277 ARG   R CA  1 
ATOM   1908 C C   . ARG   B 2 297 ? 99.115  116.991 99.359  1.00 57.73  ? 277 ARG   R C   1 
ATOM   1909 O O   . ARG   B 2 297 ? 100.198 117.314 99.868  1.00 56.52  ? 277 ARG   R O   1 
ATOM   1910 C CB  . ARG   B 2 297 ? 97.523  118.789 98.639  1.00 47.61  ? 277 ARG   R CB  1 
ATOM   1911 N N   . ILE   B 2 298 ? 98.400  115.957 99.808  1.00 55.81  ? 278 ILE   R N   1 
ATOM   1912 C CA  . ILE   B 2 298 ? 98.849  115.177 100.959 1.00 54.19  ? 278 ILE   R CA  1 
ATOM   1913 C C   . ILE   B 2 298 ? 100.108 114.389 100.626 1.00 58.25  ? 278 ILE   R C   1 
ATOM   1914 O O   . ILE   B 2 298 ? 101.012 114.256 101.462 1.00 64.28  ? 278 ILE   R O   1 
ATOM   1915 C CB  . ILE   B 2 298 ? 97.725  114.253 101.448 1.00 55.05  ? 278 ILE   R CB  1 
ATOM   1916 C CG1 . ILE   B 2 298 ? 96.410  115.016 101.523 1.00 56.29  ? 278 ILE   R CG1 1 
ATOM   1917 C CG2 . ILE   B 2 298 ? 98.072  113.696 102.802 1.00 62.23  ? 278 ILE   R CG2 1 
ATOM   1918 C CD1 . ILE   B 2 298 ? 96.491  116.266 102.347 1.00 59.20  ? 278 ILE   R CD1 1 
ATOM   1919 N N   . THR   B 2 299 ? 100.185 113.841 99.413  1.00 55.79  ? 279 THR   R N   1 
ATOM   1920 C CA  . THR   B 2 299 ? 101.390 113.144 98.989  1.00 56.40  ? 279 THR   R CA  1 
ATOM   1921 C C   . THR   B 2 299 ? 102.589 114.079 98.909  1.00 57.81  ? 279 THR   R C   1 
ATOM   1922 O O   . THR   B 2 299 ? 103.693 113.689 99.316  1.00 60.02  ? 279 THR   R O   1 
ATOM   1923 C CB  . THR   B 2 299 ? 101.161 112.472 97.638  1.00 54.73  ? 279 THR   R CB  1 
ATOM   1924 O OG1 . THR   B 2 299 ? 100.059 111.567 97.736  1.00 59.61  ? 279 THR   R OG1 1 
ATOM   1925 C CG2 . THR   B 2 299 ? 102.388 111.694 97.225  1.00 54.99  ? 279 THR   R CG2 1 
ATOM   1926 N N   . ARG   B 2 300 ? 102.392 115.308 98.417  1.00 52.09  ? 280 ARG   R N   1 
ATOM   1927 C CA  . ARG   B 2 300 ? 103.482 116.281 98.411  1.00 55.91  ? 280 ARG   R CA  1 
ATOM   1928 C C   . ARG   B 2 300 ? 103.939 116.630 99.826  1.00 53.46  ? 280 ARG   R C   1 
ATOM   1929 O O   . ARG   B 2 300 ? 105.147 116.732 100.083 1.00 55.26  ? 280 ARG   R O   1 
ATOM   1930 C CB  . ARG   B 2 300 ? 103.050 117.542 97.665  1.00 61.93  ? 280 ARG   R CB  1 
ATOM   1931 C CG  . ARG   B 2 300 ? 104.166 118.538 97.401  1.00 62.10  ? 280 ARG   R CG  1 
ATOM   1932 C CD  . ARG   B 2 300 ? 104.157 119.656 98.415  1.00 60.63  ? 280 ARG   R CD  1 
ATOM   1933 N NE  . ARG   B 2 300 ? 102.868 120.331 98.472  1.00 65.20  ? 280 ARG   R NE  1 
ATOM   1934 C CZ  . ARG   B 2 300 ? 102.472 121.262 97.618  1.00 69.47  ? 280 ARG   R CZ  1 
ATOM   1935 N NH1 . ARG   B 2 300 ? 103.250 121.665 96.628  1.00 78.02  ? 280 ARG   R NH1 1 
ATOM   1936 N NH2 . ARG   B 2 300 ? 101.268 121.805 97.763  1.00 68.16  ? 280 ARG   R NH2 1 
ATOM   1937 N N   . MET   B 2 301 ? 102.990 116.797 100.753 1.00 48.96  ? 281 MET   R N   1 
ATOM   1938 C CA  . MET   B 2 301 ? 103.340 117.103 102.140 1.00 51.93  ? 281 MET   R CA  1 
ATOM   1939 C C   . MET   B 2 301 ? 104.125 115.967 102.793 1.00 53.64  ? 281 MET   R C   1 
ATOM   1940 O O   . MET   B 2 301 ? 105.113 116.208 103.504 1.00 60.04  ? 281 MET   R O   1 
ATOM   1941 C CB  . MET   B 2 301 ? 102.074 117.404 102.938 1.00 55.05  ? 281 MET   R CB  1 
ATOM   1942 C CG  . MET   B 2 301 ? 102.310 117.755 104.389 1.00 56.81  ? 281 MET   R CG  1 
ATOM   1943 S SD  . MET   B 2 301 ? 100.765 117.995 105.278 1.00 79.51  ? 281 MET   R SD  1 
ATOM   1944 C CE  . MET   B 2 301 ? 100.415 116.326 105.817 1.00 63.03  ? 281 MET   R CE  1 
ATOM   1945 N N   . VAL   B 2 302 ? 103.709 114.721 102.552 1.00 50.02  ? 282 VAL   R N   1 
ATOM   1946 C CA  . VAL   B 2 302 ? 104.407 113.577 103.133 1.00 46.93  ? 282 VAL   R CA  1 
ATOM   1947 C C   . VAL   B 2 302 ? 105.811 113.445 102.559 1.00 45.67  ? 282 VAL   R C   1 
ATOM   1948 O O   . VAL   B 2 302 ? 106.760 113.109 103.283 1.00 45.06  ? 282 VAL   R O   1 
ATOM   1949 C CB  . VAL   B 2 302 ? 103.591 112.291 102.928 1.00 50.94  ? 282 VAL   R CB  1 
ATOM   1950 C CG1 . VAL   B 2 302 ? 104.451 111.082 103.206 1.00 53.88  ? 282 VAL   R CG1 1 
ATOM   1951 C CG2 . VAL   B 2 302 ? 102.380 112.301 103.833 1.00 57.73  ? 282 VAL   R CG2 1 
ATOM   1952 N N   . LEU   B 2 303 ? 105.974 113.705 101.257 1.00 44.67  ? 283 LEU   R N   1 
ATOM   1953 C CA  . LEU   B 2 303 ? 107.309 113.635 100.667 1.00 46.66  ? 283 LEU   R CA  1 
ATOM   1954 C C   . LEU   B 2 303 ? 108.226 114.715 101.224 1.00 48.78  ? 283 LEU   R C   1 
ATOM   1955 O O   . LEU   B 2 303 ? 109.418 114.467 101.445 1.00 51.52  ? 283 LEU   R O   1 
ATOM   1956 C CB  . LEU   B 2 303 ? 107.237 113.743 99.148  1.00 44.86  ? 283 LEU   R CB  1 
ATOM   1957 C CG  . LEU   B 2 303 ? 108.604 113.870 98.480  1.00 41.08  ? 283 LEU   R CG  1 
ATOM   1958 C CD1 . LEU   B 2 303 ? 109.486 112.707 98.862  1.00 39.25  ? 283 LEU   R CD1 1 
ATOM   1959 C CD2 . LEU   B 2 303 ? 108.454 113.931 96.984  1.00 48.84  ? 283 LEU   R CD2 1 
ATOM   1960 N N   . VAL   B 2 304 ? 107.693 115.918 101.459 1.00 48.78  ? 284 VAL   R N   1 
ATOM   1961 C CA  . VAL   B 2 304 ? 108.514 116.984 102.035 1.00 43.66  ? 284 VAL   R CA  1 
ATOM   1962 C C   . VAL   B 2 304 ? 108.939 116.638 103.458 1.00 46.08  ? 284 VAL   R C   1 
ATOM   1963 O O   . VAL   B 2 304 ? 110.082 116.898 103.858 1.00 48.67  ? 284 VAL   R O   1 
ATOM   1964 C CB  . VAL   B 2 304 ? 107.773 118.328 101.982 1.00 44.46  ? 284 VAL   R CB  1 
ATOM   1965 C CG1 . VAL   B 2 304 ? 108.507 119.342 102.810 1.00 46.21  ? 284 VAL   R CG1 1 
ATOM   1966 C CG2 . VAL   B 2 304 ? 107.665 118.801 100.554 1.00 47.67  ? 284 VAL   R CG2 1 
ATOM   1967 N N   . VAL   B 2 305 ? 108.038 116.036 104.240 1.00 45.27  ? 285 VAL   R N   1 
ATOM   1968 C CA  . VAL   B 2 305 ? 108.406 115.639 105.600 1.00 47.44  ? 285 VAL   R CA  1 
ATOM   1969 C C   . VAL   B 2 305 ? 109.461 114.533 105.601 1.00 46.95  ? 285 VAL   R C   1 
ATOM   1970 O O   . VAL   B 2 305 ? 110.395 114.558 106.418 1.00 44.72  ? 285 VAL   R O   1 
ATOM   1971 C CB  . VAL   B 2 305 ? 107.156 115.218 106.387 1.00 48.31  ? 285 VAL   R CB  1 
ATOM   1972 C CG1 . VAL   B 2 305 ? 107.548 114.341 107.553 1.00 53.74  ? 285 VAL   R CG1 1 
ATOM   1973 C CG2 . VAL   B 2 305 ? 106.409 116.443 106.868 1.00 47.98  ? 285 VAL   R CG2 1 
ATOM   1974 N N   . VAL   B 2 306 ? 109.343 113.557 104.694 1.00 47.28  ? 286 VAL   R N   1 
ATOM   1975 C CA  . VAL   B 2 306 ? 110.340 112.491 104.596 1.00 46.24  ? 286 VAL   R CA  1 
ATOM   1976 C C   . VAL   B 2 306 ? 111.703 113.046 104.194 1.00 52.40  ? 286 VAL   R C   1 
ATOM   1977 O O   . VAL   B 2 306 ? 112.739 112.641 104.742 1.00 58.29  ? 286 VAL   R O   1 
ATOM   1978 C CB  . VAL   B 2 306 ? 109.866 111.412 103.611 1.00 42.82  ? 286 VAL   R CB  1 
ATOM   1979 C CG1 . VAL   B 2 306 ? 110.957 110.410 103.378 1.00 48.51  ? 286 VAL   R CG1 1 
ATOM   1980 C CG2 . VAL   B 2 306 ? 108.639 110.723 104.145 1.00 43.09  ? 286 VAL   R CG2 1 
ATOM   1981 N N   . ALA   B 2 307 ? 111.726 113.979 103.234 1.00 48.18  ? 287 ALA   R N   1 
ATOM   1982 C CA  . ALA   B 2 307 ? 112.985 114.585 102.806 1.00 46.67  ? 287 ALA   R CA  1 
ATOM   1983 C C   . ALA   B 2 307 ? 113.633 115.386 103.926 1.00 49.55  ? 287 ALA   R C   1 
ATOM   1984 O O   . ALA   B 2 307 ? 114.858 115.337 104.097 1.00 55.08  ? 287 ALA   R O   1 
ATOM   1985 C CB  . ALA   B 2 307 ? 112.750 115.471 101.587 1.00 43.44  ? 287 ALA   R CB  1 
ATOM   1986 N N   . VAL   B 2 308 ? 112.827 116.119 104.702 1.00 43.30  ? 288 VAL   R N   1 
ATOM   1987 C CA  . VAL   B 2 308 ? 113.356 116.881 105.833 1.00 46.99  ? 288 VAL   R CA  1 
ATOM   1988 C C   . VAL   B 2 308 ? 113.972 115.957 106.876 1.00 58.33  ? 288 VAL   R C   1 
ATOM   1989 O O   . VAL   B 2 308 ? 115.066 116.230 107.390 1.00 63.32  ? 288 VAL   R O   1 
ATOM   1990 C CB  . VAL   B 2 308 ? 112.255 117.763 106.446 1.00 48.71  ? 288 VAL   R CB  1 
ATOM   1991 C CG1 . VAL   B 2 308 ? 112.634 118.171 107.853 1.00 49.92  ? 288 VAL   R CG1 1 
ATOM   1992 C CG2 . VAL   B 2 308 ? 112.031 118.989 105.588 1.00 50.85  ? 288 VAL   R CG2 1 
ATOM   1993 N N   . PHE   B 2 309 ? 113.290 114.847 107.197 1.00 59.56  ? 289 PHE   R N   1 
ATOM   1994 C CA  . PHE   B 2 309 ? 113.821 113.890 108.171 1.00 56.64  ? 289 PHE   R CA  1 
ATOM   1995 C C   . PHE   B 2 309 ? 115.136 113.279 107.703 1.00 56.98  ? 289 PHE   R C   1 
ATOM   1996 O O   . PHE   B 2 309 ? 116.089 113.169 108.487 1.00 59.72  ? 289 PHE   R O   1 
ATOM   1997 C CB  . PHE   B 2 309 ? 112.801 112.781 108.429 1.00 53.73  ? 289 PHE   R CB  1 
ATOM   1998 C CG  . PHE   B 2 309 ? 113.238 111.774 109.460 1.00 56.61  ? 289 PHE   R CG  1 
ATOM   1999 C CD1 . PHE   B 2 309 ? 113.120 112.051 110.804 1.00 60.14  ? 289 PHE   R CD1 1 
ATOM   2000 C CD2 . PHE   B 2 309 ? 113.772 110.554 109.084 1.00 59.79  ? 289 PHE   R CD2 1 
ATOM   2001 C CE1 . PHE   B 2 309 ? 113.517 111.131 111.751 1.00 60.77  ? 289 PHE   R CE1 1 
ATOM   2002 C CE2 . PHE   B 2 309 ? 114.179 109.642 110.028 1.00 62.40  ? 289 PHE   R CE2 1 
ATOM   2003 C CZ  . PHE   B 2 309 ? 114.049 109.929 111.360 1.00 59.51  ? 289 PHE   R CZ  1 
ATOM   2004 N N   . ILE   B 2 310 ? 115.207 112.875 106.430 1.00 57.55  ? 290 ILE   R N   1 
ATOM   2005 C CA  . ILE   B 2 310 ? 116.418 112.236 105.916 1.00 62.25  ? 290 ILE   R CA  1 
ATOM   2006 C C   . ILE   B 2 310 ? 117.588 113.212 105.912 1.00 61.30  ? 290 ILE   R C   1 
ATOM   2007 O O   . ILE   B 2 310 ? 118.711 112.856 106.295 1.00 61.85  ? 290 ILE   R O   1 
ATOM   2008 C CB  . ILE   B 2 310 ? 116.171 111.659 104.513 1.00 57.06  ? 290 ILE   R CB  1 
ATOM   2009 C CG1 . ILE   B 2 310 ? 115.267 110.437 104.594 1.00 58.56  ? 290 ILE   R CG1 1 
ATOM   2010 C CG2 . ILE   B 2 310 ? 117.486 111.277 103.874 1.00 49.95  ? 290 ILE   R CG2 1 
ATOM   2011 C CD1 . ILE   B 2 310 ? 115.966 109.216 105.097 1.00 60.53  ? 290 ILE   R CD1 1 
ATOM   2012 N N   . VAL   B 2 311 ? 117.344 114.458 105.494 1.00 59.23  ? 291 VAL   R N   1 
ATOM   2013 C CA  . VAL   B 2 311 ? 118.417 115.448 105.457 1.00 60.15  ? 291 VAL   R CA  1 
ATOM   2014 C C   . VAL   B 2 311 ? 118.884 115.809 106.861 1.00 59.88  ? 291 VAL   R C   1 
ATOM   2015 O O   . VAL   B 2 311 ? 120.067 116.088 107.077 1.00 68.70  ? 291 VAL   R O   1 
ATOM   2016 C CB  . VAL   B 2 311 ? 117.973 116.692 104.674 1.00 67.23  ? 291 VAL   R CB  1 
ATOM   2017 C CG1 . VAL   B 2 311 ? 119.046 117.750 104.736 1.00 63.42  ? 291 VAL   R CG1 1 
ATOM   2018 C CG2 . VAL   B 2 311 ? 117.701 116.320 103.233 1.00 76.66  ? 291 VAL   R CG2 1 
ATOM   2019 N N   . CYS   B 2 312 ? 117.977 115.827 107.836 1.00 55.43  ? 292 CYS   R N   1 
ATOM   2020 C CA  . CYS   B 2 312 ? 118.416 116.151 109.190 1.00 62.50  ? 292 CYS   R CA  1 
ATOM   2021 C C   . CYS   B 2 312 ? 119.180 114.999 109.831 1.00 68.43  ? 292 CYS   R C   1 
ATOM   2022 O O   . CYS   B 2 312 ? 120.090 115.232 110.633 1.00 67.93  ? 292 CYS   R O   1 
ATOM   2023 C CB  . CYS   B 2 312 ? 117.229 116.547 110.060 1.00 60.04  ? 292 CYS   R CB  1 
ATOM   2024 S SG  . CYS   B 2 312 ? 116.776 118.289 109.971 1.00 65.95  ? 292 CYS   R SG  1 
ATOM   2025 N N   . TRP   B 2 313 ? 118.830 113.749 109.514 1.00 68.67  ? 293 TRP   R N   1 
ATOM   2026 C CA  . TRP   B 2 313 ? 119.388 112.638 110.276 1.00 62.38  ? 293 TRP   R CA  1 
ATOM   2027 C C   . TRP   B 2 313 ? 120.507 111.868 109.588 1.00 55.99  ? 293 TRP   R C   1 
ATOM   2028 O O   . TRP   B 2 313 ? 121.149 111.050 110.249 1.00 58.00  ? 293 TRP   R O   1 
ATOM   2029 C CB  . TRP   B 2 313 ? 118.283 111.656 110.656 1.00 58.08  ? 293 TRP   R CB  1 
ATOM   2030 C CG  . TRP   B 2 313 ? 117.668 111.999 111.946 1.00 58.43  ? 293 TRP   R CG  1 
ATOM   2031 C CD1 . TRP   B 2 313 ? 116.646 112.861 112.154 1.00 63.33  ? 293 TRP   R CD1 1 
ATOM   2032 C CD2 . TRP   B 2 313 ? 118.041 111.498 113.227 1.00 64.39  ? 293 TRP   R CD2 1 
ATOM   2033 N NE1 . TRP   B 2 313 ? 116.346 112.930 113.488 1.00 66.32  ? 293 TRP   R NE1 1 
ATOM   2034 C CE2 . TRP   B 2 313 ? 117.192 112.099 114.171 1.00 69.75  ? 293 TRP   R CE2 1 
ATOM   2035 C CE3 . TRP   B 2 313 ? 119.011 110.596 113.668 1.00 69.24  ? 293 TRP   R CE3 1 
ATOM   2036 C CZ2 . TRP   B 2 313 ? 117.281 111.830 115.530 1.00 77.55  ? 293 TRP   R CZ2 1 
ATOM   2037 C CZ3 . TRP   B 2 313 ? 119.100 110.329 115.016 1.00 74.21  ? 293 TRP   R CZ3 1 
ATOM   2038 C CH2 . TRP   B 2 313 ? 118.241 110.945 115.934 1.00 80.16  ? 293 TRP   R CH2 1 
ATOM   2039 N N   . THR   B 2 314 ? 120.755 112.078 108.297 1.00 56.75  ? 294 THR   R N   1 
ATOM   2040 C CA  . THR   B 2 314 ? 121.846 111.361 107.632 1.00 55.99  ? 294 THR   R CA  1 
ATOM   2041 C C   . THR   B 2 314 ? 123.247 111.657 108.169 1.00 53.74  ? 294 THR   R C   1 
ATOM   2042 O O   . THR   B 2 314 ? 124.025 110.694 108.338 1.00 54.91  ? 294 THR   R O   1 
ATOM   2043 C CB  . THR   B 2 314 ? 121.794 111.632 106.128 1.00 57.21  ? 294 THR   R CB  1 
ATOM   2044 O OG1 . THR   B 2 314 ? 120.573 111.116 105.590 1.00 61.36  ? 294 THR   R OG1 1 
ATOM   2045 C CG2 . THR   B 2 314 ? 122.962 110.963 105.437 1.00 48.81  ? 294 THR   R CG2 1 
ATOM   2046 N N   . PRO   B 2 315 ? 123.668 112.925 108.377 1.00 51.92  ? 295 PRO   R N   1 
ATOM   2047 C CA  . PRO   B 2 315 ? 125.064 113.175 108.789 1.00 49.56  ? 295 PRO   R CA  1 
ATOM   2048 C C   . PRO   B 2 315 ? 125.483 112.557 110.111 1.00 56.18  ? 295 PRO   R C   1 
ATOM   2049 O O   . PRO   B 2 315 ? 126.618 112.080 110.207 1.00 61.38  ? 295 PRO   R O   1 
ATOM   2050 C CB  . PRO   B 2 315 ? 125.144 114.707 108.848 1.00 42.56  ? 295 PRO   R CB  1 
ATOM   2051 C CG  . PRO   B 2 315 ? 123.757 115.193 108.769 1.00 48.18  ? 295 PRO   R CG  1 
ATOM   2052 C CD  . PRO   B 2 315 ? 123.018 114.186 107.987 1.00 51.29  ? 295 PRO   R CD  1 
ATOM   2053 N N   . ILE   B 2 316 ? 124.604 112.502 111.115 1.00 58.88  ? 296 ILE   R N   1 
ATOM   2054 C CA  . ILE   B 2 316 ? 124.993 111.883 112.380 1.00 52.25  ? 296 ILE   R CA  1 
ATOM   2055 C C   . ILE   B 2 316 ? 125.189 110.381 112.225 1.00 49.73  ? 296 ILE   R C   1 
ATOM   2056 O O   . ILE   B 2 316 ? 126.108 109.812 112.815 1.00 54.60  ? 296 ILE   R O   1 
ATOM   2057 C CB  . ILE   B 2 316 ? 123.998 112.215 113.501 1.00 48.62  ? 296 ILE   R CB  1 
ATOM   2058 C CG1 . ILE   B 2 316 ? 124.558 111.692 114.816 1.00 47.01  ? 296 ILE   R CG1 1 
ATOM   2059 C CG2 . ILE   B 2 316 ? 122.641 111.634 113.236 1.00 47.91  ? 296 ILE   R CG2 1 
ATOM   2060 C CD1 . ILE   B 2 316 ? 125.820 112.368 115.241 1.00 52.72  ? 296 ILE   R CD1 1 
ATOM   2061 N N   . HIS   B 2 317 ? 124.359 109.718 111.417 1.00 45.79  ? 297 HIS   R N   1 
ATOM   2062 C CA  . HIS   B 2 317 ? 124.498 108.277 111.229 1.00 43.99  ? 297 HIS   R CA  1 
ATOM   2063 C C   . HIS   B 2 317 ? 125.785 107.936 110.498 1.00 49.51  ? 297 HIS   R C   1 
ATOM   2064 O O   . HIS   B 2 317 ? 126.546 107.047 110.923 1.00 59.84  ? 297 HIS   R O   1 
ATOM   2065 C CB  . HIS   B 2 317 ? 123.321 107.734 110.440 1.00 42.91  ? 297 HIS   R CB  1 
ATOM   2066 C CG  . HIS   B 2 317 ? 122.134 107.363 111.268 1.00 49.16  ? 297 HIS   R CG  1 
ATOM   2067 N ND1 . HIS   B 2 317 ? 121.111 108.242 111.535 1.00 59.07  ? 297 HIS   R ND1 1 
ATOM   2068 C CD2 . HIS   B 2 317 ? 121.796 106.200 111.867 1.00 51.23  ? 297 HIS   R CD2 1 
ATOM   2069 C CE1 . HIS   B 2 317 ? 120.194 107.639 112.268 1.00 57.52  ? 297 HIS   R CE1 1 
ATOM   2070 N NE2 . HIS   B 2 317 ? 120.588 106.399 112.486 1.00 55.80  ? 297 HIS   R NE2 1 
ATOM   2071 N N   . ILE   B 2 318 ? 126.045 108.637 109.388 1.00 44.19  ? 298 ILE   R N   1 
ATOM   2072 C CA  . ILE   B 2 318 ? 127.274 108.389 108.637 1.00 48.67  ? 298 ILE   R CA  1 
ATOM   2073 C C   . ILE   B 2 318 ? 128.495 108.735 109.477 1.00 56.81  ? 298 ILE   R C   1 
ATOM   2074 O O   . ILE   B 2 318 ? 129.509 108.032 109.438 1.00 57.44  ? 298 ILE   R O   1 
ATOM   2075 C CB  . ILE   B 2 318 ? 127.274 109.168 107.313 1.00 46.79  ? 298 ILE   R CB  1 
ATOM   2076 C CG1 . ILE   B 2 318 ? 126.172 108.658 106.395 1.00 53.64  ? 298 ILE   R CG1 1 
ATOM   2077 C CG2 . ILE   B 2 318 ? 128.608 109.029 106.635 1.00 50.05  ? 298 ILE   R CG2 1 
ATOM   2078 C CD1 . ILE   B 2 318 ? 126.000 109.496 105.164 1.00 60.46  ? 298 ILE   R CD1 1 
ATOM   2079 N N   . TYR   B 2 319 ? 128.394 109.781 110.299 1.00 56.29  ? 299 TYR   R N   1 
ATOM   2080 C CA  . TYR   B 2 319 ? 129.544 110.222 111.072 1.00 51.93  ? 299 TYR   R CA  1 
ATOM   2081 C C   . TYR   B 2 319 ? 129.812 109.276 112.237 1.00 56.23  ? 299 TYR   R C   1 
ATOM   2082 O O   . TYR   B 2 319 ? 130.970 109.061 112.606 1.00 58.19  ? 299 TYR   R O   1 
ATOM   2083 C CB  . TYR   B 2 319 ? 129.291 111.650 111.539 1.00 48.12  ? 299 TYR   R CB  1 
ATOM   2084 C CG  . TYR   B 2 319 ? 130.481 112.405 112.056 1.00 52.73  ? 299 TYR   R CG  1 
ATOM   2085 C CD1 . TYR   B 2 319 ? 131.771 111.949 111.853 1.00 55.55  ? 299 TYR   R CD1 1 
ATOM   2086 C CD2 . TYR   B 2 319 ? 130.312 113.617 112.690 1.00 58.73  ? 299 TYR   R CD2 1 
ATOM   2087 C CE1 . TYR   B 2 319 ? 132.849 112.655 112.310 1.00 67.42  ? 299 TYR   R CE1 1 
ATOM   2088 C CE2 . TYR   B 2 319 ? 131.383 114.333 113.139 1.00 63.67  ? 299 TYR   R CE2 1 
ATOM   2089 C CZ  . TYR   B 2 319 ? 132.647 113.850 112.949 1.00 70.50  ? 299 TYR   R CZ  1 
ATOM   2090 O OH  . TYR   B 2 319 ? 133.715 114.573 113.405 1.00 75.23  ? 299 TYR   R OH  1 
ATOM   2091 N N   . VAL   B 2 320 ? 128.763 108.683 112.813 1.00 55.52  ? 300 VAL   R N   1 
ATOM   2092 C CA  . VAL   B 2 320 ? 128.954 107.640 113.820 1.00 54.28  ? 300 VAL   R CA  1 
ATOM   2093 C C   . VAL   B 2 320 ? 129.657 106.431 113.229 1.00 60.21  ? 300 VAL   R C   1 
ATOM   2094 O O   . VAL   B 2 320 ? 130.554 105.860 113.858 1.00 64.38  ? 300 VAL   R O   1 
ATOM   2095 C CB  . VAL   B 2 320 ? 127.618 107.244 114.464 1.00 46.83  ? 300 VAL   R CB  1 
ATOM   2096 C CG1 . VAL   B 2 320 ? 127.837 106.092 115.395 1.00 46.46  ? 300 VAL   R CG1 1 
ATOM   2097 C CG2 . VAL   B 2 320 ? 127.106 108.393 115.271 1.00 53.96  ? 300 VAL   R CG2 1 
ATOM   2098 N N   . ILE   B 2 321 ? 129.273 106.019 112.017 1.00 58.59  ? 301 ILE   R N   1 
ATOM   2099 C CA  . ILE   B 2 321 ? 129.950 104.872 111.404 1.00 58.28  ? 301 ILE   R CA  1 
ATOM   2100 C C   . ILE   B 2 321 ? 131.408 105.198 111.078 1.00 62.37  ? 301 ILE   R C   1 
ATOM   2101 O O   . ILE   B 2 321 ? 132.307 104.371 111.293 1.00 65.29  ? 301 ILE   R O   1 
ATOM   2102 C CB  . ILE   B 2 321 ? 129.194 104.391 110.161 1.00 57.19  ? 301 ILE   R CB  1 
ATOM   2103 C CG1 . ILE   B 2 321 ? 127.922 103.676 110.587 1.00 54.91  ? 301 ILE   R CG1 1 
ATOM   2104 C CG2 . ILE   B 2 321 ? 130.065 103.449 109.387 1.00 65.40  ? 301 ILE   R CG2 1 
ATOM   2105 C CD1 . ILE   B 2 321 ? 128.193 102.455 111.404 1.00 56.08  ? 301 ILE   R CD1 1 
ATOM   2106 N N   . ILE   B 2 322 ? 131.664 106.407 110.563 1.00 62.89  ? 302 ILE   R N   1 
ATOM   2107 C CA  . ILE   B 2 322 ? 133.032 106.807 110.222 1.00 64.17  ? 302 ILE   R CA  1 
ATOM   2108 C C   . ILE   B 2 322 ? 133.901 106.888 111.469 1.00 68.31  ? 302 ILE   R C   1 
ATOM   2109 O O   . ILE   B 2 322 ? 135.074 106.502 111.452 1.00 72.66  ? 302 ILE   R O   1 
ATOM   2110 C CB  . ILE   B 2 322 ? 133.044 108.135 109.449 1.00 58.39  ? 302 ILE   R CB  1 
ATOM   2111 C CG1 . ILE   B 2 322 ? 132.234 108.007 108.164 1.00 68.17  ? 302 ILE   R CG1 1 
ATOM   2112 C CG2 . ILE   B 2 322 ? 134.460 108.549 109.151 1.00 53.53  ? 302 ILE   R CG2 1 
ATOM   2113 C CD1 . ILE   B 2 322 ? 132.766 106.969 107.212 1.00 77.82  ? 302 ILE   R CD1 1 
ATOM   2114 N N   . LYS   B 2 323 ? 133.345 107.389 112.573 1.00 65.37  ? 303 LYS   R N   1 
ATOM   2115 C CA  . LYS   B 2 323 ? 134.072 107.329 113.834 1.00 64.63  ? 303 LYS   R CA  1 
ATOM   2116 C C   . LYS   B 2 323 ? 134.254 105.895 114.308 1.00 69.17  ? 303 LYS   R C   1 
ATOM   2117 O O   . LYS   B 2 323 ? 135.226 105.595 115.008 1.00 73.93  ? 303 LYS   R O   1 
ATOM   2118 C CB  . LYS   B 2 323 ? 133.352 108.141 114.903 1.00 62.77  ? 303 LYS   R CB  1 
ATOM   2119 C CG  . LYS   B 2 323 ? 134.103 108.204 116.208 1.00 59.77  ? 303 LYS   R CG  1 
ATOM   2120 C CD  . LYS   B 2 323 ? 133.598 109.333 117.079 1.00 62.88  ? 303 LYS   R CD  1 
ATOM   2121 C CE  . LYS   B 2 323 ? 133.955 110.686 116.498 1.00 73.52  ? 303 LYS   R CE  1 
ATOM   2122 N NZ  . LYS   B 2 323 ? 134.204 111.686 117.574 1.00 75.08  ? 303 LYS   R NZ  1 
ATOM   2123 N N   . ALA   B 2 324 ? 133.325 105.002 113.954 1.00 68.63  ? 304 ALA   R N   1 
ATOM   2124 C CA  . ALA   B 2 324 ? 133.428 103.613 114.384 1.00 67.85  ? 304 ALA   R CA  1 
ATOM   2125 C C   . ALA   B 2 324 ? 134.615 102.912 113.744 1.00 71.47  ? 304 ALA   R C   1 
ATOM   2126 O O   . ALA   B 2 324 ? 135.423 102.293 114.442 1.00 75.15  ? 304 ALA   R O   1 
ATOM   2127 C CB  . ALA   B 2 324 ? 132.137 102.863 114.067 1.00 67.77  ? 304 ALA   R CB  1 
ATOM   2128 N N   . LEU   B 2 325 ? 134.751 102.991 112.420 1.00 73.70  ? 305 LEU   R N   1 
ATOM   2129 C CA  . LEU   B 2 325 ? 135.824 102.212 111.804 1.00 79.28  ? 305 LEU   R CA  1 
ATOM   2130 C C   . LEU   B 2 325 ? 136.993 103.031 111.277 1.00 83.07  ? 305 LEU   R C   1 
ATOM   2131 O O   . LEU   B 2 325 ? 138.115 102.524 111.269 1.00 82.89  ? 305 LEU   R O   1 
ATOM   2132 C CB  . LEU   B 2 325 ? 135.300 101.321 110.663 1.00 76.35  ? 305 LEU   R CB  1 
ATOM   2133 C CG  . LEU   B 2 325 ? 134.849 101.802 109.282 1.00 75.03  ? 305 LEU   R CG  1 
ATOM   2134 C CD1 . LEU   B 2 325 ? 134.786 100.611 108.365 1.00 80.31  ? 305 LEU   R CD1 1 
ATOM   2135 C CD2 . LEU   B 2 325 ? 133.491 102.439 109.322 1.00 62.81  ? 305 LEU   R CD2 1 
ATOM   2136 N N   . ILE   B 2 326 ? 136.774 104.269 110.827 1.00 81.57  ? 306 ILE   R N   1 
ATOM   2137 C CA  . ILE   B 2 326 ? 137.863 105.024 110.211 1.00 80.78  ? 306 ILE   R CA  1 
ATOM   2138 C C   . ILE   B 2 326 ? 138.903 105.430 111.243 1.00 90.32  ? 306 ILE   R C   1 
ATOM   2139 O O   . ILE   B 2 326 ? 140.080 105.606 110.907 1.00 97.92  ? 306 ILE   R O   1 
ATOM   2140 C CB  . ILE   B 2 326 ? 137.316 106.249 109.455 1.00 73.19  ? 306 ILE   R CB  1 
ATOM   2141 N N   . THR   B 2 327 ? 138.494 105.579 112.505 1.00 91.40  ? 307 THR   R N   1 
ATOM   2142 C CA  . THR   B 2 327 ? 139.382 105.988 113.598 1.00 97.93  ? 307 THR   R CA  1 
ATOM   2143 C C   . THR   B 2 327 ? 139.967 107.377 113.346 1.00 103.25 ? 307 THR   R C   1 
ATOM   2144 O O   . THR   B 2 327 ? 141.182 107.558 113.243 1.00 98.75  ? 307 THR   R O   1 
ATOM   2145 C CB  . THR   B 2 327 ? 140.492 104.958 113.826 1.00 89.95  ? 307 THR   R CB  1 
ATOM   2146 N N   . ILE   B 2 328 ? 139.082 108.360 113.236 1.00 105.56 ? 308 ILE   R N   1 
ATOM   2147 C CA  . ILE   B 2 328 ? 139.498 109.741 112.960 1.00 106.97 ? 308 ILE   R CA  1 
ATOM   2148 C C   . ILE   B 2 328 ? 140.254 110.287 114.165 1.00 121.17 ? 308 ILE   R C   1 
ATOM   2149 O O   . ILE   B 2 328 ? 139.890 109.970 115.312 1.00 125.36 ? 308 ILE   R O   1 
ATOM   2150 C CB  . ILE   B 2 328 ? 138.279 110.606 112.635 1.00 94.66  ? 308 ILE   R CB  1 
ATOM   2151 N N   . PRO   B 2 329 ? 141.298 111.099 113.970 1.00 122.32 ? 309 PRO   R N   1 
ATOM   2152 C CA  . PRO   B 2 329 ? 142.039 111.634 115.120 1.00 115.24 ? 309 PRO   R CA  1 
ATOM   2153 C C   . PRO   B 2 329 ? 141.281 112.740 115.834 1.00 112.87 ? 309 PRO   R C   1 
ATOM   2154 O O   . PRO   B 2 329 ? 140.155 113.073 115.457 1.00 111.41 ? 309 PRO   R O   1 
ATOM   2155 C CB  . PRO   B 2 329 ? 143.334 112.155 114.488 1.00 108.27 ? 309 PRO   R CB  1 
ATOM   2156 C CG  . PRO   B 2 329 ? 142.946 112.505 113.097 1.00 112.99 ? 309 PRO   R CG  1 
ATOM   2157 C CD  . PRO   B 2 329 ? 141.879 111.526 112.686 1.00 113.67 ? 309 PRO   R CD  1 
ATOM   2158 N N   . GLU   B 2 330 ? 141.889 113.317 116.864 1.00 111.31 ? 310 GLU   R N   1 
ATOM   2159 C CA  . GLU   B 2 330 ? 141.281 114.397 117.627 1.00 113.41 ? 310 GLU   R CA  1 
ATOM   2160 C C   . GLU   B 2 330 ? 141.695 115.731 117.017 1.00 112.24 ? 310 GLU   R C   1 
ATOM   2161 O O   . GLU   B 2 330 ? 142.889 116.043 116.948 1.00 114.65 ? 310 GLU   R O   1 
ATOM   2162 C CB  . GLU   B 2 330 ? 141.690 114.324 119.098 1.00 114.78 ? 310 GLU   R CB  1 
ATOM   2163 N N   . THR   B 2 331 ? 140.712 116.514 116.584 1.00 107.33 ? 311 THR   R N   1 
ATOM   2164 C CA  . THR   B 2 331 ? 140.967 117.776 115.909 1.00 108.01 ? 311 THR   R CA  1 
ATOM   2165 C C   . THR   B 2 331 ? 140.036 118.843 116.463 1.00 106.15 ? 311 THR   R C   1 
ATOM   2166 O O   . THR   B 2 331 ? 138.970 118.539 117.004 1.00 102.75 ? 311 THR   R O   1 
ATOM   2167 C CB  . THR   B 2 331 ? 140.777 117.657 114.390 1.00 103.72 ? 311 THR   R CB  1 
ATOM   2168 N N   . THR   B 2 332 ? 140.455 120.102 116.322 1.00 105.82 ? 312 THR   R N   1 
ATOM   2169 C CA  . THR   B 2 332 ? 139.676 121.209 116.865 1.00 103.58 ? 312 THR   R CA  1 
ATOM   2170 C C   . THR   B 2 332 ? 138.351 121.377 116.131 1.00 104.85 ? 312 THR   R C   1 
ATOM   2171 O O   . THR   B 2 332 ? 137.349 121.776 116.733 1.00 106.36 ? 312 THR   R O   1 
ATOM   2172 C CB  . THR   B 2 332 ? 140.489 122.501 116.809 1.00 91.55  ? 312 THR   R CB  1 
ATOM   2173 N N   . PHE   B 2 333 ? 138.329 121.109 114.824 1.00 95.53  ? 313 PHE   R N   1 
ATOM   2174 C CA  . PHE   B 2 333 ? 137.084 121.222 114.071 1.00 85.42  ? 313 PHE   R CA  1 
ATOM   2175 C C   . PHE   B 2 333 ? 136.222 119.973 114.185 1.00 84.95  ? 313 PHE   R C   1 
ATOM   2176 O O   . PHE   B 2 333 ? 134.997 120.054 114.025 1.00 83.65  ? 313 PHE   R O   1 
ATOM   2177 C CB  . PHE   B 2 333 ? 137.379 121.503 112.598 1.00 80.42  ? 313 PHE   R CB  1 
ATOM   2178 N N   . GLN   B 2 334 ? 136.838 118.823 114.467 1.00 83.80  ? 314 GLN   R N   1 
ATOM   2179 C CA  . GLN   B 2 334 ? 136.123 117.552 114.401 1.00 82.49  ? 314 GLN   R CA  1 
ATOM   2180 C C   . GLN   B 2 334 ? 135.092 117.438 115.518 1.00 78.26  ? 314 GLN   R C   1 
ATOM   2181 O O   . GLN   B 2 334 ? 133.958 117.007 115.276 1.00 76.71  ? 314 GLN   R O   1 
ATOM   2182 C CB  . GLN   B 2 334 ? 137.141 116.404 114.428 1.00 84.33  ? 314 GLN   R CB  1 
ATOM   2183 C CG  . GLN   B 2 334 ? 136.619 114.985 114.172 1.00 85.92  ? 314 GLN   R CG  1 
ATOM   2184 C CD  . GLN   B 2 334 ? 136.101 114.283 115.414 1.00 86.39  ? 314 GLN   R CD  1 
ATOM   2185 O OE1 . GLN   B 2 334 ? 135.210 113.440 115.340 1.00 82.74  ? 314 GLN   R OE1 1 
ATOM   2186 N NE2 . GLN   B 2 334 ? 136.649 114.643 116.566 1.00 86.74  ? 314 GLN   R NE2 1 
ATOM   2187 N N   . THR   B 2 335 ? 135.458 117.842 116.738 1.00 76.19  ? 315 THR   R N   1 
ATOM   2188 C CA  . THR   B 2 335 ? 134.522 117.777 117.858 1.00 78.41  ? 315 THR   R CA  1 
ATOM   2189 C C   . THR   B 2 335 ? 133.343 118.728 117.662 1.00 79.90  ? 315 THR   R C   1 
ATOM   2190 O O   . THR   B 2 335 ? 132.193 118.385 117.976 1.00 78.71  ? 315 THR   R O   1 
ATOM   2191 C CB  . THR   B 2 335 ? 135.251 118.092 119.163 1.00 70.44  ? 315 THR   R CB  1 
ATOM   2192 N N   . VAL   B 2 336 ? 133.609 119.924 117.135 1.00 77.29  ? 316 VAL   R N   1 
ATOM   2193 C CA  . VAL   B 2 336 ? 132.536 120.883 116.895 1.00 73.13  ? 316 VAL   R CA  1 
ATOM   2194 C C   . VAL   B 2 336 ? 131.611 120.386 115.793 1.00 68.29  ? 316 VAL   R C   1 
ATOM   2195 O O   . VAL   B 2 336 ? 130.392 120.582 115.855 1.00 63.68  ? 316 VAL   R O   1 
ATOM   2196 C CB  . VAL   B 2 336 ? 133.119 122.268 116.568 1.00 74.94  ? 316 VAL   R CB  1 
ATOM   2197 C CG1 . VAL   B 2 336 ? 132.004 123.281 116.430 1.00 72.43  ? 316 VAL   R CG1 1 
ATOM   2198 C CG2 . VAL   B 2 336 ? 134.105 122.693 117.639 1.00 71.51  ? 316 VAL   R CG2 1 
ATOM   2199 N N   . SER   B 2 337 ? 132.168 119.733 114.769 1.00 67.45  ? 317 SER   R N   1 
ATOM   2200 C CA  . SER   B 2 337 ? 131.332 119.154 113.720 1.00 68.90  ? 317 SER   R CA  1 
ATOM   2201 C C   . SER   B 2 337 ? 130.458 118.033 114.269 1.00 67.83  ? 317 SER   R C   1 
ATOM   2202 O O   . SER   B 2 337 ? 129.287 117.897 113.891 1.00 63.22  ? 317 SER   R O   1 
ATOM   2203 C CB  . SER   B 2 337 ? 132.205 118.635 112.580 1.00 73.56  ? 317 SER   R CB  1 
ATOM   2204 O OG  . SER   B 2 337 ? 132.980 117.528 113.002 1.00 70.66  ? 317 SER   R OG  1 
ATOM   2205 N N   . TRP   B 2 338 ? 131.024 117.215 115.160 1.00 69.35  ? 318 TRP   R N   1 
ATOM   2206 C CA  . TRP   B 2 338 ? 130.286 116.121 115.789 1.00 66.07  ? 318 TRP   R CA  1 
ATOM   2207 C C   . TRP   B 2 338 ? 129.107 116.650 116.601 1.00 62.70  ? 318 TRP   R C   1 
ATOM   2208 O O   . TRP   B 2 338 ? 127.976 116.149 116.498 1.00 64.21  ? 318 TRP   R O   1 
ATOM   2209 C CB  . TRP   B 2 338 ? 131.261 115.319 116.657 1.00 62.27  ? 318 TRP   R CB  1 
ATOM   2210 C CG  . TRP   B 2 338 ? 130.669 114.335 117.599 1.00 63.04  ? 318 TRP   R CG  1 
ATOM   2211 C CD1 . TRP   B 2 338 ? 130.380 114.535 118.910 1.00 71.16  ? 318 TRP   R CD1 1 
ATOM   2212 C CD2 . TRP   B 2 338 ? 130.370 112.967 117.328 1.00 61.35  ? 318 TRP   R CD2 1 
ATOM   2213 N NE1 . TRP   B 2 338 ? 129.873 113.390 119.464 1.00 74.58  ? 318 TRP   R NE1 1 
ATOM   2214 C CE2 . TRP   B 2 338 ? 129.860 112.411 118.510 1.00 64.57  ? 318 TRP   R CE2 1 
ATOM   2215 C CE3 . TRP   B 2 338 ? 130.461 112.165 116.195 1.00 65.71  ? 318 TRP   R CE3 1 
ATOM   2216 C CZ2 . TRP   B 2 338 ? 129.446 111.092 118.591 1.00 64.64  ? 318 TRP   R CZ2 1 
ATOM   2217 C CZ3 . TRP   B 2 338 ? 130.051 110.858 116.278 1.00 68.16  ? 318 TRP   R CZ3 1 
ATOM   2218 C CH2 . TRP   B 2 338 ? 129.550 110.333 117.466 1.00 67.66  ? 318 TRP   R CH2 1 
ATOM   2219 N N   . HIS   B 2 339 ? 129.340 117.689 117.390 1.00 58.95  ? 319 HIS   R N   1 
ATOM   2220 C CA  . HIS   B 2 339 ? 128.294 118.284 118.210 1.00 52.18  ? 319 HIS   R CA  1 
ATOM   2221 C C   . HIS   B 2 339 ? 127.323 119.123 117.409 1.00 57.54  ? 319 HIS   R C   1 
ATOM   2222 O O   . HIS   B 2 339 ? 126.301 119.515 117.903 1.00 55.14  ? 319 HIS   R O   1 
ATOM   2223 C CB  . HIS   B 2 339 ? 128.897 119.100 119.315 1.00 54.33  ? 319 HIS   R CB  1 
ATOM   2224 C CG  . HIS   B 2 339 ? 129.726 118.303 120.261 1.00 56.97  ? 319 HIS   R CG  1 
ATOM   2225 N ND1 . HIS   B 2 339 ? 129.198 117.316 121.055 1.00 54.86  ? 319 HIS   R ND1 1 
ATOM   2226 C CD2 . HIS   B 2 339 ? 131.042 118.358 120.553 1.00 62.86  ? 319 HIS   R CD2 1 
ATOM   2227 C CE1 . HIS   B 2 339 ? 130.157 116.788 121.788 1.00 57.01  ? 319 HIS   R CE1 1 
ATOM   2228 N NE2 . HIS   B 2 339 ? 131.285 117.405 121.505 1.00 63.34  ? 319 HIS   R NE2 1 
ATOM   2229 N N   . PHE   B 2 340 ? 127.673 119.457 116.182 1.00 63.45  ? 320 PHE   R N   1 
ATOM   2230 C CA  . PHE   B 2 340 ? 126.773 120.129 115.331 1.00 64.53  ? 320 PHE   R CA  1 
ATOM   2231 C C   . PHE   B 2 340 ? 125.836 119.021 114.893 1.00 59.20  ? 320 PHE   R C   1 
ATOM   2232 O O   . PHE   B 2 340 ? 124.650 119.111 115.186 1.00 54.61  ? 320 PHE   R O   1 
ATOM   2233 C CB  . PHE   B 2 340 ? 127.540 120.766 114.166 1.00 64.76  ? 320 PHE   R CB  1 
ATOM   2234 C CG  . PHE   B 2 340 ? 126.700 121.074 112.978 1.00 63.18  ? 320 PHE   R CG  1 
ATOM   2235 C CD1 . PHE   B 2 340 ? 125.811 122.098 113.009 1.00 63.59  ? 320 PHE   R CD1 1 
ATOM   2236 C CD2 . PHE   B 2 340 ? 126.815 120.331 111.840 1.00 62.37  ? 320 PHE   R CD2 1 
ATOM   2237 C CE1 . PHE   B 2 340 ? 125.030 122.373 111.923 1.00 66.52  ? 320 PHE   R CE1 1 
ATOM   2238 C CE2 . PHE   B 2 340 ? 126.039 120.585 110.750 1.00 63.23  ? 320 PHE   R CE2 1 
ATOM   2239 C CZ  . PHE   B 2 340 ? 125.144 121.613 110.791 1.00 65.57  ? 320 PHE   R CZ  1 
ATOM   2240 N N   . CYS   B 2 341 ? 126.381 117.927 114.337 1.00 55.54  ? 321 CYS   R N   1 
ATOM   2241 C CA  . CYS   B 2 341 ? 125.578 116.860 113.747 1.00 54.03  ? 321 CYS   R CA  1 
ATOM   2242 C C   . CYS   B 2 341 ? 124.557 116.315 114.742 1.00 52.75  ? 321 CYS   R C   1 
ATOM   2243 O O   . CYS   B 2 341 ? 123.387 116.094 114.391 1.00 52.45  ? 321 CYS   R O   1 
ATOM   2244 C CB  . CYS   B 2 341 ? 126.493 115.752 113.241 1.00 54.75  ? 321 CYS   R CB  1 
ATOM   2245 S SG  . CYS   B 2 341 ? 127.436 116.187 111.770 1.00 61.06  ? 321 CYS   R SG  1 
ATOM   2246 N N   . ILE   B 2 342 ? 124.974 116.120 115.998 1.00 54.31  ? 322 ILE   R N   1 
ATOM   2247 C CA  . ILE   B 2 342 ? 124.037 115.658 117.023 1.00 51.63  ? 322 ILE   R CA  1 
ATOM   2248 C C   . ILE   B 2 342 ? 122.963 116.711 117.284 1.00 63.31  ? 322 ILE   R C   1 
ATOM   2249 O O   . ILE   B 2 342 ? 121.783 116.387 117.492 1.00 66.00  ? 322 ILE   R O   1 
ATOM   2250 C CB  . ILE   B 2 342 ? 124.790 115.300 118.313 1.00 47.02  ? 322 ILE   R CB  1 
ATOM   2251 C CG1 . ILE   B 2 342 ? 125.621 114.045 118.113 1.00 44.77  ? 322 ILE   R CG1 1 
ATOM   2252 C CG2 . ILE   B 2 342 ? 123.810 115.059 119.424 1.00 54.34  ? 322 ILE   R CG2 1 
ATOM   2253 C CD1 . ILE   B 2 342 ? 126.385 113.646 119.330 1.00 51.18  ? 322 ILE   R CD1 1 
ATOM   2254 N N   . ALA   B 2 343 ? 123.352 117.990 117.269 1.00 66.06  ? 323 ALA   R N   1 
ATOM   2255 C CA  . ALA   B 2 343 ? 122.396 119.072 117.436 1.00 60.39  ? 323 ALA   R CA  1 
ATOM   2256 C C   . ALA   B 2 343 ? 121.386 119.127 116.304 1.00 62.35  ? 323 ALA   R C   1 
ATOM   2257 O O   . ALA   B 2 343 ? 120.216 119.409 116.556 1.00 63.86  ? 323 ALA   R O   1 
ATOM   2258 C CB  . ALA   B 2 343 ? 123.135 120.403 117.541 1.00 58.78  ? 323 ALA   R CB  1 
ATOM   2259 N N   . LEU   B 2 344 ? 121.816 118.869 115.070 1.00 61.62  ? 324 LEU   R N   1 
ATOM   2260 C CA  . LEU   B 2 344 ? 120.891 118.789 113.942 1.00 63.98  ? 324 LEU   R CA  1 
ATOM   2261 C C   . LEU   B 2 344 ? 119.901 117.645 114.123 1.00 64.82  ? 324 LEU   R C   1 
ATOM   2262 O O   . LEU   B 2 344 ? 118.699 117.797 113.845 1.00 68.83  ? 324 LEU   R O   1 
ATOM   2263 C CB  . LEU   B 2 344 ? 121.683 118.608 112.649 1.00 59.85  ? 324 LEU   R CB  1 
ATOM   2264 C CG  . LEU   B 2 344 ? 121.073 119.040 111.323 1.00 60.71  ? 324 LEU   R CG  1 
ATOM   2265 C CD1 . LEU   B 2 344 ? 120.509 120.437 111.430 1.00 67.14  ? 324 LEU   R CD1 1 
ATOM   2266 C CD2 . LEU   B 2 344 ? 122.117 118.958 110.225 1.00 55.35  ? 324 LEU   R CD2 1 
ATOM   2267 N N   . GLY   B 2 345 ? 120.399 116.494 114.587 1.00 59.76  ? 325 GLY   R N   1 
ATOM   2268 C CA  . GLY   B 2 345 ? 119.525 115.357 114.828 1.00 59.15  ? 325 GLY   R CA  1 
ATOM   2269 C C   . GLY   B 2 345 ? 118.456 115.635 115.867 1.00 62.93  ? 325 GLY   R C   1 
ATOM   2270 O O   . GLY   B 2 345 ? 117.314 115.199 115.724 1.00 67.33  ? 325 GLY   R O   1 
ATOM   2271 N N   . TYR   B 2 346 ? 118.808 116.368 116.925 1.00 65.63  ? 326 TYR   R N   1 
ATOM   2272 C CA  . TYR   B 2 346 ? 117.784 116.781 117.888 1.00 63.63  ? 326 TYR   R CA  1 
ATOM   2273 C C   . TYR   B 2 346 ? 116.892 117.891 117.338 1.00 65.19  ? 326 TYR   R C   1 
ATOM   2274 O O   . TYR   B 2 346 ? 115.700 117.948 117.657 1.00 64.37  ? 326 TYR   R O   1 
ATOM   2275 C CB  . TYR   B 2 346 ? 118.421 117.223 119.201 1.00 61.07  ? 326 TYR   R CB  1 
ATOM   2276 C CG  . TYR   B 2 346 ? 118.862 116.086 120.079 1.00 66.07  ? 326 TYR   R CG  1 
ATOM   2277 C CD1 . TYR   B 2 346 ? 118.236 114.854 120.010 1.00 66.28  ? 326 TYR   R CD1 1 
ATOM   2278 C CD2 . TYR   B 2 346 ? 119.883 116.251 120.998 1.00 70.72  ? 326 TYR   R CD2 1 
ATOM   2279 C CE1 . TYR   B 2 346 ? 118.624 113.813 120.819 1.00 65.95  ? 326 TYR   R CE1 1 
ATOM   2280 C CE2 . TYR   B 2 346 ? 120.279 115.217 121.811 1.00 72.60  ? 326 TYR   R CE2 1 
ATOM   2281 C CZ  . TYR   B 2 346 ? 119.646 114.001 121.718 1.00 72.97  ? 326 TYR   R CZ  1 
ATOM   2282 O OH  . TYR   B 2 346 ? 120.039 112.966 122.530 1.00 79.22  ? 326 TYR   R OH  1 
ATOM   2283 N N   . THR   B 2 347 ? 117.448 118.788 116.521 1.00 69.60  ? 327 THR   R N   1 
ATOM   2284 C CA  . THR   B 2 347 ? 116.722 119.935 115.989 1.00 71.88  ? 327 THR   R CA  1 
ATOM   2285 C C   . THR   B 2 347 ? 115.654 119.543 114.984 1.00 72.21  ? 327 THR   R C   1 
ATOM   2286 O O   . THR   B 2 347 ? 114.748 120.342 114.734 1.00 75.45  ? 327 THR   R O   1 
ATOM   2287 C CB  . THR   B 2 347 ? 117.708 120.900 115.325 1.00 73.43  ? 327 THR   R CB  1 
ATOM   2288 O OG1 . THR   B 2 347 ? 118.829 121.107 116.190 1.00 73.80  ? 327 THR   R OG1 1 
ATOM   2289 C CG2 . THR   B 2 347 ? 117.057 122.240 115.030 1.00 71.22  ? 327 THR   R CG2 1 
ATOM   2290 N N   . ASN   B 2 348 ? 115.750 118.348 114.393 1.00 72.93  ? 328 ASN   R N   1 
ATOM   2291 C CA  . ASN   B 2 348 ? 114.741 117.913 113.424 1.00 70.28  ? 328 ASN   R CA  1 
ATOM   2292 C C   . ASN   B 2 348 ? 113.344 117.796 114.035 1.00 73.45  ? 328 ASN   R C   1 
ATOM   2293 O O   . ASN   B 2 348 ? 112.349 117.939 113.321 1.00 74.26  ? 328 ASN   R O   1 
ATOM   2294 C CB  . ASN   B 2 348 ? 115.136 116.573 112.813 1.00 69.94  ? 328 ASN   R CB  1 
ATOM   2295 C CG  . ASN   B 2 348 ? 114.317 116.229 111.594 1.00 76.42  ? 328 ASN   R CG  1 
ATOM   2296 O OD1 . ASN   B 2 348 ? 113.574 117.054 111.077 1.00 82.64  ? 328 ASN   R OD1 1 
ATOM   2297 N ND2 . ASN   B 2 348 ? 114.440 114.999 111.132 1.00 73.39  ? 328 ASN   R ND2 1 
ATOM   2298 N N   . SER   B 2 349 ? 113.241 117.536 115.340 1.00 78.18  ? 329 SER   R N   1 
ATOM   2299 C CA  . SER   B 2 349 ? 111.930 117.415 115.977 1.00 78.81  ? 329 SER   R CA  1 
ATOM   2300 C C   . SER   B 2 349 ? 111.171 118.738 115.978 1.00 79.98  ? 329 SER   R C   1 
ATOM   2301 O O   . SER   B 2 349 ? 109.937 118.755 116.007 1.00 76.86  ? 329 SER   R O   1 
ATOM   2302 C CB  . SER   B 2 349 ? 112.095 116.901 117.403 1.00 73.99  ? 329 SER   R CB  1 
ATOM   2303 O OG  . SER   B 2 349 ? 110.842 116.810 118.049 1.00 70.98  ? 329 SER   R OG  1 
ATOM   2304 N N   . CYS   B 2 350 ? 111.894 119.855 115.967 1.00 83.78  ? 330 CYS   R N   1 
ATOM   2305 C CA  . CYS   B 2 350 ? 111.268 121.170 116.028 1.00 79.16  ? 330 CYS   R CA  1 
ATOM   2306 C C   . CYS   B 2 350 ? 110.555 121.547 114.735 1.00 79.97  ? 330 CYS   R C   1 
ATOM   2307 O O   . CYS   B 2 350 ? 109.570 122.289 114.767 1.00 85.61  ? 330 CYS   R O   1 
ATOM   2308 C CB  . CYS   B 2 350 ? 112.330 122.212 116.357 1.00 78.44  ? 330 CYS   R CB  1 
ATOM   2309 S SG  . CYS   B 2 350 ? 111.724 123.881 116.478 1.00 99.05  ? 330 CYS   R SG  1 
ATOM   2310 N N   . LEU   B 2 351 ? 111.043 121.070 113.590 1.00 75.99  ? 331 LEU   R N   1 
ATOM   2311 C CA  . LEU   B 2 351 ? 110.657 121.667 112.314 1.00 72.75  ? 331 LEU   R CA  1 
ATOM   2312 C C   . LEU   B 2 351 ? 109.268 121.234 111.862 1.00 74.08  ? 331 LEU   R C   1 
ATOM   2313 O O   . LEU   B 2 351 ? 108.558 122.007 111.211 1.00 73.07  ? 331 LEU   R O   1 
ATOM   2314 C CB  . LEU   B 2 351 ? 111.690 121.318 111.248 1.00 70.21  ? 331 LEU   R CB  1 
ATOM   2315 C CG  . LEU   B 2 351 ? 113.113 121.712 111.622 1.00 68.47  ? 331 LEU   R CG  1 
ATOM   2316 C CD1 . LEU   B 2 351 ? 114.088 121.249 110.566 1.00 71.96  ? 331 LEU   R CD1 1 
ATOM   2317 C CD2 . LEU   B 2 351 ? 113.199 123.207 111.821 1.00 73.28  ? 331 LEU   R CD2 1 
ATOM   2318 N N   . ASN   B 2 352 ? 108.873 120.001 112.170 1.00 73.17  ? 332 ASN   R N   1 
ATOM   2319 C CA  . ASN   B 2 352 ? 107.700 119.357 111.576 1.00 70.12  ? 332 ASN   R CA  1 
ATOM   2320 C C   . ASN   B 2 352 ? 106.359 120.055 111.819 1.00 67.79  ? 332 ASN   R C   1 
ATOM   2321 O O   . ASN   B 2 352 ? 105.558 120.145 110.880 1.00 70.29  ? 332 ASN   R O   1 
ATOM   2322 C CB  . ASN   B 2 352 ? 107.625 117.905 112.043 1.00 71.31  ? 332 ASN   R CB  1 
ATOM   2323 C CG  . ASN   B 2 352 ? 108.619 117.017 111.321 1.00 73.06  ? 332 ASN   R CG  1 
ATOM   2324 O OD1 . ASN   B 2 352 ? 109.325 117.464 110.422 1.00 70.09  ? 332 ASN   R OD1 1 
ATOM   2325 N ND2 . ASN   B 2 352 ? 108.680 115.754 111.711 1.00 72.71  ? 332 ASN   R ND2 1 
ATOM   2326 N N   . PRO   B 2 353 ? 106.040 120.524 113.047 1.00 65.10  ? 333 PRO   R N   1 
ATOM   2327 C CA  . PRO   B 2 353 ? 104.819 121.328 113.224 1.00 63.86  ? 333 PRO   R CA  1 
ATOM   2328 C C   . PRO   B 2 353 ? 104.801 122.607 112.402 1.00 69.49  ? 333 PRO   R C   1 
ATOM   2329 O O   . PRO   B 2 353 ? 103.747 123.031 111.917 1.00 73.50  ? 333 PRO   R O   1 
ATOM   2330 C CB  . PRO   B 2 353 ? 104.820 121.631 114.724 1.00 65.79  ? 333 PRO   R CB  1 
ATOM   2331 C CG  . PRO   B 2 353 ? 105.544 120.503 115.320 1.00 65.96  ? 333 PRO   R CG  1 
ATOM   2332 C CD  . PRO   B 2 353 ? 106.612 120.131 114.345 1.00 63.41  ? 333 PRO   R CD  1 
ATOM   2333 N N   . VAL   B 2 354 ? 105.973 123.214 112.212 1.00 72.54  ? 334 VAL   R N   1 
ATOM   2334 C CA  . VAL   B 2 354 ? 106.072 124.395 111.358 1.00 76.33  ? 334 VAL   R CA  1 
ATOM   2335 C C   . VAL   B 2 354 ? 105.755 124.047 109.908 1.00 74.51  ? 334 VAL   R C   1 
ATOM   2336 O O   . VAL   B 2 354 ? 105.091 124.816 109.205 1.00 77.14  ? 334 VAL   R O   1 
ATOM   2337 C CB  . VAL   B 2 354 ? 107.463 125.034 111.490 1.00 76.18  ? 334 VAL   R CB  1 
ATOM   2338 C CG1 . VAL   B 2 354 ? 107.645 126.098 110.430 1.00 75.33  ? 334 VAL   R CG1 1 
ATOM   2339 C CG2 . VAL   B 2 354 ? 107.638 125.614 112.875 1.00 72.76  ? 334 VAL   R CG2 1 
ATOM   2340 N N   . LEU   B 2 355 ? 106.242 122.898 109.431 1.00 68.60  ? 335 LEU   R N   1 
ATOM   2341 C CA  . LEU   B 2 355 ? 105.923 122.466 108.073 1.00 70.23  ? 335 LEU   R CA  1 
ATOM   2342 C C   . LEU   B 2 355 ? 104.440 122.158 107.931 1.00 74.12  ? 335 LEU   R C   1 
ATOM   2343 O O   . LEU   B 2 355 ? 103.819 122.490 106.916 1.00 81.58  ? 335 LEU   R O   1 
ATOM   2344 C CB  . LEU   B 2 355 ? 106.756 121.245 107.692 1.00 66.38  ? 335 LEU   R CB  1 
ATOM   2345 C CG  . LEU   B 2 355 ? 108.243 121.474 107.468 1.00 69.11  ? 335 LEU   R CG  1 
ATOM   2346 C CD1 . LEU   B 2 355 ? 108.903 120.177 107.072 1.00 65.28  ? 335 LEU   R CD1 1 
ATOM   2347 C CD2 . LEU   B 2 355 ? 108.453 122.527 106.410 1.00 71.77  ? 335 LEU   R CD2 1 
ATOM   2348 N N   . TYR   B 2 356 ? 103.850 121.523 108.943 1.00 68.90  ? 336 TYR   R N   1 
ATOM   2349 C CA  . TYR   B 2 356 ? 102.426 121.219 108.890 1.00 67.02  ? 336 TYR   R CA  1 
ATOM   2350 C C   . TYR   B 2 356 ? 101.570 122.472 108.979 1.00 78.60  ? 336 TYR   R C   1 
ATOM   2351 O O   . TYR   B 2 356 ? 100.401 122.435 108.586 1.00 86.20  ? 336 TYR   R O   1 
ATOM   2352 C CB  . TYR   B 2 356 ? 102.050 120.256 110.013 1.00 63.56  ? 336 TYR   R CB  1 
ATOM   2353 C CG  . TYR   B 2 356 ? 102.622 118.882 109.823 1.00 61.70  ? 336 TYR   R CG  1 
ATOM   2354 C CD1 . TYR   B 2 356 ? 102.727 118.333 108.562 1.00 65.45  ? 336 TYR   R CD1 1 
ATOM   2355 C CD2 . TYR   B 2 356 ? 103.071 118.140 110.900 1.00 58.12  ? 336 TYR   R CD2 1 
ATOM   2356 C CE1 . TYR   B 2 356 ? 103.255 117.080 108.374 1.00 66.86  ? 336 TYR   R CE1 1 
ATOM   2357 C CE2 . TYR   B 2 356 ? 103.603 116.884 110.724 1.00 56.18  ? 336 TYR   R CE2 1 
ATOM   2358 C CZ  . TYR   B 2 356 ? 103.693 116.359 109.455 1.00 62.64  ? 336 TYR   R CZ  1 
ATOM   2359 O OH  . TYR   B 2 356 ? 104.222 115.107 109.252 1.00 65.22  ? 336 TYR   R OH  1 
ATOM   2360 N N   . ALA   B 2 357 ? 102.116 123.566 109.517 1.00 78.61  ? 337 ALA   R N   1 
ATOM   2361 C CA  . ALA   B 2 357 ? 101.362 124.812 109.597 1.00 82.83  ? 337 ALA   R CA  1 
ATOM   2362 C C   . ALA   B 2 357 ? 101.009 125.357 108.219 1.00 85.78  ? 337 ALA   R C   1 
ATOM   2363 O O   . ALA   B 2 357 ? 99.887  125.826 108.009 1.00 88.75  ? 337 ALA   R O   1 
ATOM   2364 C CB  . ALA   B 2 357 ? 102.149 125.851 110.391 1.00 83.38  ? 337 ALA   R CB  1 
ATOM   2365 N N   . PHE   B 2 358 ? 101.946 125.323 107.264 1.00 81.17  ? 338 PHE   R N   1 
ATOM   2366 C CA  . PHE   B 2 358 ? 101.650 125.879 105.947 1.00 86.55  ? 338 PHE   R CA  1 
ATOM   2367 C C   . PHE   B 2 358 ? 101.873 124.891 104.805 1.00 79.02  ? 338 PHE   R C   1 
ATOM   2368 O O   . PHE   B 2 358 ? 102.050 125.314 103.661 1.00 79.33  ? 338 PHE   R O   1 
ATOM   2369 C CB  . PHE   B 2 358 ? 102.428 127.180 105.694 1.00 85.17  ? 338 PHE   R CB  1 
ATOM   2370 C CG  . PHE   B 2 358 ? 103.923 127.029 105.663 1.00 83.37  ? 338 PHE   R CG  1 
ATOM   2371 C CD1 . PHE   B 2 358 ? 104.662 127.153 106.823 1.00 85.56  ? 338 PHE   R CD1 1 
ATOM   2372 C CD2 . PHE   B 2 358 ? 104.596 126.831 104.468 1.00 87.76  ? 338 PHE   R CD2 1 
ATOM   2373 C CE1 . PHE   B 2 358 ? 106.039 127.038 106.798 1.00 93.56  ? 338 PHE   R CE1 1 
ATOM   2374 C CE2 . PHE   B 2 358 ? 105.968 126.712 104.438 1.00 94.80  ? 338 PHE   R CE2 1 
ATOM   2375 C CZ  . PHE   B 2 358 ? 106.692 126.817 105.602 1.00 96.42  ? 338 PHE   R CZ  1 
ATOM   2376 N N   . LEU   B 2 359 ? 101.848 123.590 105.073 1.00 75.59  ? 339 LEU   R N   1 
ATOM   2377 C CA  . LEU   B 2 359 ? 101.765 122.626 103.986 1.00 75.24  ? 339 LEU   R CA  1 
ATOM   2378 C C   . LEU   B 2 359 ? 100.376 122.022 103.836 1.00 82.76  ? 339 LEU   R C   1 
ATOM   2379 O O   . LEU   B 2 359 ? 100.052 121.519 102.756 1.00 83.90  ? 339 LEU   R O   1 
ATOM   2380 C CB  . LEU   B 2 359 ? 102.792 121.506 104.179 1.00 75.09  ? 339 LEU   R CB  1 
ATOM   2381 C CG  . LEU   B 2 359 ? 104.202 121.784 103.652 1.00 75.12  ? 339 LEU   R CG  1 
ATOM   2382 C CD1 . LEU   B 2 359 ? 105.168 120.723 104.120 1.00 74.48  ? 339 LEU   R CD1 1 
ATOM   2383 C CD2 . LEU   B 2 359 ? 104.205 121.857 102.143 1.00 71.37  ? 339 LEU   R CD2 1 
ATOM   2384 N N   . ASP   B 2 360 ? 99.554  122.069 104.883 1.00 88.40  ? 340 ASP   R N   1 
ATOM   2385 C CA  . ASP   B 2 360 ? 98.182  121.578 104.853 1.00 91.04  ? 340 ASP   R CA  1 
ATOM   2386 C C   . ASP   B 2 360 ? 97.283  122.750 105.226 1.00 91.58  ? 340 ASP   R C   1 
ATOM   2387 O O   . ASP   B 2 360 ? 97.505  123.406 106.248 1.00 87.15  ? 340 ASP   R O   1 
ATOM   2388 C CB  . ASP   B 2 360 ? 98.006  120.401 105.828 1.00 88.69  ? 340 ASP   R CB  1 
ATOM   2389 C CG  . ASP   B 2 360 ? 96.621  119.732 105.757 1.00 96.90  ? 340 ASP   R CG  1 
ATOM   2390 O OD1 . ASP   B 2 360 ? 95.644  120.284 105.209 1.00 99.38  ? 340 ASP   R OD1 1 
ATOM   2391 O OD2 . ASP   B 2 360 ? 96.524  118.583 106.232 1.00 102.00 ? 340 ASP   R OD2 1 
ATOM   2392 N N   . GLU   B 2 361 ? 96.265  122.999 104.401 1.00 97.81  ? 341 GLU   R N   1 
ATOM   2393 C CA  . GLU   B 2 361 ? 95.382  124.139 104.631 1.00 100.07 ? 341 GLU   R CA  1 
ATOM   2394 C C   . GLU   B 2 361 ? 94.524  123.942 105.873 1.00 101.61 ? 341 GLU   R C   1 
ATOM   2395 O O   . GLU   B 2 361 ? 94.269  124.898 106.617 1.00 106.34 ? 341 GLU   R O   1 
ATOM   2396 C CB  . GLU   B 2 361 ? 94.501  124.371 103.405 1.00 94.28  ? 341 GLU   R CB  1 
ATOM   2397 N N   . ASN   B 2 362 ? 94.050  122.714 106.100 1.00 95.94  ? 342 ASN   R N   1 
ATOM   2398 C CA  . ASN   B 2 362 ? 93.193  122.442 107.251 1.00 94.92  ? 342 ASN   R CA  1 
ATOM   2399 C C   . ASN   B 2 362 ? 93.946  122.627 108.562 1.00 94.73  ? 342 ASN   R C   1 
ATOM   2400 O O   . ASN   B 2 362 ? 93.386  123.134 109.541 1.00 95.59  ? 342 ASN   R O   1 
ATOM   2401 C CB  . ASN   B 2 362 ? 92.622  121.031 107.151 1.00 94.84  ? 342 ASN   R CB  1 
ATOM   2402 C CG  . ASN   B 2 362 ? 91.499  120.929 106.145 1.00 104.34 ? 342 ASN   R CG  1 
ATOM   2403 O OD1 . ASN   B 2 362 ? 90.967  121.939 105.686 1.00 105.21 ? 342 ASN   R OD1 1 
ATOM   2404 N ND2 . ASN   B 2 362 ? 91.134  119.704 105.792 1.00 110.55 ? 342 ASN   R ND2 1 
ATOM   2405 N N   . PHE   B 2 363 ? 95.217  122.222 108.595 1.00 92.76  ? 343 PHE   R N   1 
ATOM   2406 C CA  . PHE   B 2 363 ? 96.043  122.445 109.776 1.00 94.05  ? 343 PHE   R CA  1 
ATOM   2407 C C   . PHE   B 2 363 ? 96.232  123.931 110.042 1.00 97.00  ? 343 PHE   R C   1 
ATOM   2408 O O   . PHE   B 2 363 ? 96.181  124.370 111.196 1.00 99.91  ? 343 PHE   R O   1 
ATOM   2409 C CB  . PHE   B 2 363 ? 97.400  121.766 109.606 1.00 94.00  ? 343 PHE   R CB  1 
ATOM   2410 C CG  . PHE   B 2 363 ? 97.445  120.358 110.114 1.00 89.81  ? 343 PHE   R CG  1 
ATOM   2411 C CD1 . PHE   B 2 363 ? 97.130  120.072 111.425 1.00 87.66  ? 343 PHE   R CD1 1 
ATOM   2412 C CD2 . PHE   B 2 363 ? 97.820  119.323 109.281 1.00 87.08  ? 343 PHE   R CD2 1 
ATOM   2413 C CE1 . PHE   B 2 363 ? 97.177  118.778 111.890 1.00 81.83  ? 343 PHE   R CE1 1 
ATOM   2414 C CE2 . PHE   B 2 363 ? 97.867  118.030 109.742 1.00 81.48  ? 343 PHE   R CE2 1 
ATOM   2415 C CZ  . PHE   B 2 363 ? 97.547  117.757 111.046 1.00 76.16  ? 343 PHE   R CZ  1 
ATOM   2416 N N   . LYS   B 2 364 ? 96.451  124.721 108.986 1.00 96.63  ? 344 LYS   R N   1 
ATOM   2417 C CA  . LYS   B 2 364 ? 96.616  126.163 109.152 1.00 98.79  ? 344 LYS   R CA  1 
ATOM   2418 C C   . LYS   B 2 364 ? 95.341  126.810 109.672 1.00 102.44 ? 344 LYS   R C   1 
ATOM   2419 O O   . LYS   B 2 364 ? 95.390  127.667 110.565 1.00 105.54 ? 344 LYS   R O   1 
ATOM   2420 C CB  . LYS   B 2 364 ? 97.028  126.803 107.827 1.00 92.01  ? 344 LYS   R CB  1 
ATOM   2421 N N   . ARG   B 2 365 ? 94.189  126.406 109.129 1.00 103.78 ? 345 ARG   R N   1 
ATOM   2422 C CA  . ARG   B 2 365 ? 92.918  126.956 109.589 1.00 106.01 ? 345 ARG   R CA  1 
ATOM   2423 C C   . ARG   B 2 365 ? 92.646  126.581 111.039 1.00 106.16 ? 345 ARG   R C   1 
ATOM   2424 O O   . ARG   B 2 365 ? 92.183  127.415 111.824 1.00 107.31 ? 345 ARG   R O   1 
ATOM   2425 C CB  . ARG   B 2 365 ? 91.781  126.476 108.688 1.00 106.71 ? 345 ARG   R CB  1 
ATOM   2426 N N   . CYS   B 2 366 ? 92.941  125.336 111.417 1.00 103.03 ? 346 CYS   R N   1 
ATOM   2427 C CA  . CYS   B 2 366 ? 92.698  124.913 112.792 1.00 106.99 ? 346 CYS   R CA  1 
ATOM   2428 C C   . CYS   B 2 366 ? 93.666  125.580 113.764 1.00 106.82 ? 346 CYS   R C   1 
ATOM   2429 O O   . CYS   B 2 366 ? 93.298  125.869 114.909 1.00 109.76 ? 346 CYS   R O   1 
ATOM   2430 C CB  . CYS   B 2 366 ? 92.776  123.391 112.893 1.00 104.22 ? 346 CYS   R CB  1 
ATOM   2431 S SG  . CYS   B 2 366 ? 91.335  122.558 112.202 1.00 99.88  ? 346 CYS   R SG  1 
ATOM   2432 N N   . PHE   B 2 367 ? 94.911  125.816 113.340 1.00 100.46 ? 347 PHE   R N   1 
ATOM   2433 C CA  . PHE   B 2 367 ? 95.841  126.562 114.180 1.00 96.42  ? 347 PHE   R CA  1 
ATOM   2434 C C   . PHE   B 2 367 ? 95.373  127.997 114.372 1.00 106.23 ? 347 PHE   R C   1 
ATOM   2435 O O   . PHE   B 2 367 ? 95.436  128.534 115.484 1.00 107.93 ? 347 PHE   R O   1 
ATOM   2436 C CB  . PHE   B 2 367 ? 97.241  126.550 113.570 1.00 98.77  ? 347 PHE   R CB  1 
ATOM   2437 C CG  . PHE   B 2 367 ? 97.935  125.225 113.646 1.00 99.55  ? 347 PHE   R CG  1 
ATOM   2438 C CD1 . PHE   B 2 367 ? 97.516  124.254 114.530 1.00 100.57 ? 347 PHE   R CD1 1 
ATOM   2439 C CD2 . PHE   B 2 367 ? 99.025  124.959 112.837 1.00 93.71  ? 347 PHE   R CD2 1 
ATOM   2440 C CE1 . PHE   B 2 367 ? 98.164  123.036 114.596 1.00 93.33  ? 347 PHE   R CE1 1 
ATOM   2441 C CE2 . PHE   B 2 367 ? 99.675  123.747 112.902 1.00 87.86  ? 347 PHE   R CE2 1 
ATOM   2442 C CZ  . PHE   B 2 367 ? 99.244  122.785 113.782 1.00 87.90  ? 347 PHE   R CZ  1 
ATOM   2443 N N   . ARG   B 2 368 ? 94.900  128.637 113.298 1.00 111.28 ? 348 ARG   R N   1 
ATOM   2444 C CA  . ARG   B 2 368 ? 94.503  130.039 113.389 1.00 112.76 ? 348 ARG   R CA  1 
ATOM   2445 C C   . ARG   B 2 368 ? 93.233  130.205 114.215 1.00 114.37 ? 348 ARG   R C   1 
ATOM   2446 O O   . ARG   B 2 368 ? 93.155  131.087 115.077 1.00 116.51 ? 348 ARG   R O   1 
ATOM   2447 C CB  . ARG   B 2 368 ? 94.315  130.621 111.989 1.00 113.04 ? 348 ARG   R CB  1 
ATOM   2448 N N   . GLU   B 2 369 ? 92.224  129.367 113.963 1.00 116.01 ? 349 GLU   R N   1 
ATOM   2449 C CA  . GLU   B 2 369 ? 90.941  129.519 114.645 1.00 122.76 ? 349 GLU   R CA  1 
ATOM   2450 C C   . GLU   B 2 369 ? 91.044  129.163 116.124 1.00 120.89 ? 349 GLU   R C   1 
ATOM   2451 O O   . GLU   B 2 369 ? 90.385  129.786 116.964 1.00 118.86 ? 349 GLU   R O   1 
ATOM   2452 C CB  . GLU   B 2 369 ? 89.878  128.660 113.961 1.00 120.79 ? 349 GLU   R CB  1 
ATOM   2453 N N   . PHE   B 2 370 ? 91.846  128.156 116.454 1.00 116.10 ? 350 PHE   R N   1 
ATOM   2454 C CA  . PHE   B 2 370 ? 92.034  127.727 117.833 1.00 110.37 ? 350 PHE   R CA  1 
ATOM   2455 C C   . PHE   B 2 370 ? 92.676  128.818 118.679 1.00 106.29 ? 350 PHE   R C   1 
ATOM   2456 O O   . PHE   B 2 370 ? 93.881  129.044 118.600 1.00 105.49 ? 350 PHE   R O   1 
ATOM   2457 C CB  . PHE   B 2 370 ? 92.891  126.463 117.882 1.00 107.06 ? 350 PHE   R CB  1 
HETATM 2458 C C01 . A1APV C 3 .   ? 119.045 111.554 118.052 1.00 60.65  ? 501 A1APV R C01 1 
HETATM 2459 C C02 . A1APV C 3 .   ? 120.329 111.834 118.524 1.00 61.13  ? 501 A1APV R C02 1 
HETATM 2460 C C03 . A1APV C 3 .   ? 121.178 110.955 119.602 1.00 67.57  ? 501 A1APV R C03 1 
HETATM 2461 N N04 . A1APV C 3 .   ? 121.560 109.841 119.024 1.00 64.64  ? 501 A1APV R N04 1 
HETATM 2462 C C05 . A1APV C 3 .   ? 121.367 108.535 119.937 1.00 58.96  ? 501 A1APV R C05 1 
HETATM 2463 C C06 . A1APV C 3 .   ? 122.652 107.428 119.987 1.00 63.43  ? 501 A1APV R C06 1 
HETATM 2464 C C07 . A1APV C 3 .   ? 123.802 107.776 119.243 1.00 63.47  ? 501 A1APV R C07 1 
HETATM 2465 C C08 . A1APV C 3 .   ? 125.035 106.946 119.872 1.00 62.61  ? 501 A1APV R C08 1 
HETATM 2466 C C09 . A1APV C 3 .   ? 126.430 107.556 119.557 1.00 62.26  ? 501 A1APV R C09 1 
HETATM 2467 O O10 . A1APV C 3 .   ? 127.488 107.032 119.959 1.00 63.17  ? 501 A1APV R O10 1 
HETATM 2468 C C11 . A1APV C 3 .   ? 126.452 108.971 118.621 1.00 55.05  ? 501 A1APV R C11 1 
HETATM 2469 C C12 . A1APV C 3 .   ? 125.283 109.984 118.842 1.00 56.05  ? 501 A1APV R C12 1 
HETATM 2470 C C13 . A1APV C 3 .   ? 123.868 109.349 119.266 1.00 60.94  ? 501 A1APV R C13 1 
HETATM 2471 C C14 . A1APV C 3 .   ? 122.688 109.968 118.398 1.00 65.47  ? 501 A1APV R C14 1 
HETATM 2472 C C15 . A1APV C 3 .   ? 122.404 109.329 116.927 1.00 59.78  ? 501 A1APV R C15 1 
HETATM 2473 C C16 . A1APV C 3 .   ? 123.087 107.796 116.734 1.00 61.44  ? 501 A1APV R C16 1 
HETATM 2474 C C17 . A1APV C 3 .   ? 123.710 107.185 117.877 1.00 61.95  ? 501 A1APV R C17 1 
HETATM 2475 C C18 . A1APV C 3 .   ? 124.300 105.944 117.832 1.00 58.16  ? 501 A1APV R C18 1 
HETATM 2476 C C19 . A1APV C 3 .   ? 124.288 105.201 116.523 1.00 54.08  ? 501 A1APV R C19 1 
HETATM 2477 C C20 . A1APV C 3 .   ? 123.670 105.788 115.367 1.00 51.06  ? 501 A1APV R C20 1 
HETATM 2478 C C21 . A1APV C 3 .   ? 123.065 107.074 115.447 1.00 56.75  ? 501 A1APV R C21 1 
HETATM 2479 O O22 . A1APV C 3 .   ? 124.907 103.874 116.419 1.00 59.17  ? 501 A1APV R O22 1 
HETATM 2480 O O23 . A1APV C 3 .   ? 124.876 105.677 119.309 1.00 58.96  ? 501 A1APV R O23 1 
HETATM 2481 O O24 . A1APV C 3 .   ? 123.654 109.777 120.653 1.00 58.77  ? 501 A1APV R O24 1 
HETATM 2482 C C14 . A1APU D 4 .   ? 123.812 117.077 123.257 1.00 62.44  ? 502 A1APU R C14 1 
HETATM 2483 C C13 . A1APU D 4 .   ? 124.893 116.359 123.724 1.00 68.02  ? 502 A1APU R C13 1 
HETATM 2484 C C12 . A1APU D 4 .   ? 124.826 115.681 124.945 1.00 71.02  ? 502 A1APU R C12 1 
HETATM 2485 C C11 . A1APU D 4 .   ? 124.656 114.296 127.304 1.00 66.64  ? 502 A1APU R C11 1 
HETATM 2486 C C10 . A1APU D 4 .   ? 124.376 113.684 126.098 1.00 71.57  ? 502 A1APU R C10 1 
HETATM 2487 C C15 . A1APU D 4 .   ? 123.924 117.780 122.085 1.00 59.26  ? 502 A1APU R C15 1 
HETATM 2488 C C17 . A1APU D 4 .   ? 122.139 119.353 122.369 1.00 68.44  ? 502 A1APU R C17 1 
HETATM 2489 C C01 . A1APU D 4 .   ? 126.805 106.509 123.867 1.00 71.16  ? 502 A1APU R C01 1 
HETATM 2490 N N02 . A1APU D 4 .   ? 126.349 107.705 124.532 1.00 70.72  ? 502 A1APU R N02 1 
HETATM 2491 C C03 . A1APU D 4 .   ? 124.958 108.009 124.425 1.00 70.27  ? 502 A1APU R C03 1 
HETATM 2492 C C04 . A1APU D 4 .   ? 124.379 109.234 125.087 1.00 68.50  ? 502 A1APU R C04 1 
HETATM 2493 N N05 . A1APU D 4 .   ? 124.439 110.450 124.269 1.00 78.68  ? 502 A1APU R N05 1 
HETATM 2494 C C06 . A1APU D 4 .   ? 125.607 111.128 123.695 1.00 74.21  ? 502 A1APU R C06 1 
HETATM 2495 C C07 . A1APU D 4 .   ? 125.462 112.406 122.885 1.00 60.80  ? 502 A1APU R C07 1 
HETATM 2496 S S08 . A1APU D 4 .   ? 124.059 113.413 123.419 1.00 65.52  ? 502 A1APU R S08 1 
HETATM 2497 C C09 . A1APU D 4 .   ? 124.453 114.352 124.902 1.00 72.89  ? 502 A1APU R C09 1 
HETATM 2498 O O16 . A1APU D 4 .   ? 122.848 118.481 121.540 1.00 63.85  ? 502 A1APU R O16 1 
HETATM 2499 C C18 . A1APU D 4 .   ? 121.360 120.321 121.471 1.00 69.53  ? 502 A1APU R C18 1 
HETATM 2500 C C19 . A1APU D 4 .   ? 120.753 119.875 120.328 1.00 67.40  ? 502 A1APU R C19 1 
HETATM 2501 C C20 . A1APU D 4 .   ? 120.056 120.738 119.516 1.00 61.95  ? 502 A1APU R C20 1 
HETATM 2502 C C21 . A1APU D 4 .   ? 119.965 122.063 119.836 1.00 60.54  ? 502 A1APU R C21 1 
HETATM 2503 C C22 . A1APU D 4 .   ? 120.578 122.517 120.970 1.00 64.98  ? 502 A1APU R C22 1 
HETATM 2504 C C23 . A1APU D 4 .   ? 121.268 121.649 121.782 1.00 69.41  ? 502 A1APU R C23 1 
HETATM 2505 C C24 . A1APU D 4 .   ? 125.101 117.777 121.410 1.00 57.47  ? 502 A1APU R C24 1 
HETATM 2506 N N25 . A1APU D 4 .   ? 126.119 117.121 121.886 1.00 59.67  ? 502 A1APU R N25 1 
HETATM 2507 C C26 . A1APU D 4 .   ? 126.057 116.444 123.007 1.00 65.64  ? 502 A1APU R C26 1 
HETATM 2508 C C27 . A1APU D 4 .   ? 125.118 116.315 126.163 1.00 69.74  ? 502 A1APU R C27 1 
HETATM 2509 C C28 . A1APU D 4 .   ? 125.029 115.625 127.314 1.00 67.36  ? 502 A1APU R C28 1 
HETATM 2510 C C29 . A1APU D 4 .   ? 125.314 116.256 128.529 1.00 73.15  ? 502 A1APU R C29 1 
HETATM 2511 C C30 . A1APU D 4 .   ? 125.692 117.588 128.518 1.00 80.80  ? 502 A1APU R C30 1 
HETATM 2512 C C31 . A1APU D 4 .   ? 125.790 118.315 127.339 1.00 80.85  ? 502 A1APU R C31 1 
HETATM 2513 C C32 . A1APU D 4 .   ? 125.498 117.678 126.155 1.00 75.89  ? 502 A1APU R C32 1 
HETATM 2514 O O33 . A1APU D 4 .   ? 126.693 110.706 123.827 1.00 74.84  ? 502 A1APU R O33 1 
HETATM 2515 C C34 . A1APU D 4 .   ? 122.921 108.945 125.331 1.00 62.10  ? 502 A1APU R C34 1 
HETATM 2516 C C35 . A1APU D 4 .   ? 122.417 109.888 126.384 1.00 66.98  ? 502 A1APU R C35 1 
HETATM 2517 C C36 . A1APU D 4 .   ? 121.280 110.629 126.176 1.00 69.99  ? 502 A1APU R C36 1 
HETATM 2518 C C37 . A1APU D 4 .   ? 120.830 111.485 127.163 1.00 69.07  ? 502 A1APU R C37 1 
HETATM 2519 O O38 . A1APU D 4 .   ? 119.673 112.233 126.977 1.00 64.23  ? 502 A1APU R O38 1 
HETATM 2520 C C39 . A1APU D 4 .   ? 119.004 111.909 125.806 1.00 55.88  ? 502 A1APU R C39 1 
HETATM 2521 C C40 . A1APU D 4 .   ? 121.530 111.598 128.341 1.00 63.11  ? 502 A1APU R C40 1 
HETATM 2522 C C41 . A1APU D 4 .   ? 121.049 112.541 129.420 1.00 59.32  ? 502 A1APU R C41 1 
HETATM 2523 C C42 . A1APU D 4 .   ? 122.665 110.865 128.544 1.00 60.95  ? 502 A1APU R C42 1 
HETATM 2524 C C43 . A1APU D 4 .   ? 123.109 110.006 127.559 1.00 64.33  ? 502 A1APU R C43 1 
HETATM 2525 O O44 . A1APU D 4 .   ? 124.282 107.275 123.822 1.00 69.77  ? 502 A1APU R O44 1 
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