HEADER VIRAL PROTEIN/IMMUNE SYSTEM 30-MAY-24 9C22 TITLE CRYSTAL STRUCTURE OF CHIMERIC HEMAGGLUTININ CH11/1 IN COMPLEX WITH TITLE 2 BROAD PROTECTIVE ANTIBODY 3E1 COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: B, C, H, I, L, P, Q, U, V, Y, a, b; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: ANTIBODY 3E1 FAB LIGHT CHAIN; COMPND 7 CHAIN: D, J, M, R, W, c; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: ANTIBODY 3E1 FAB HEAVY CHAIN; COMPND 11 CHAIN: E, K, N, S, X, d; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 11320; SOURCE 4 GENE: HA; SOURCE 5 EXPRESSION_SYSTEM: TRICHOPLUSIA NI; SOURCE 6 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 7111; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_COMMON: HUMAN; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 10029 KEYWDS VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA X-RAY DIFFRACTION AUTHOR T.K.Y.NGUYEN,I.A.WILSON REVDAT 1 07-MAY-25 9C22 0 JRNL AUTH T.K.Y.NGUYEN JRNL TITL CRYSTAL STRUCTURE OF CHIMERIC HEMAGGLUTININ CH11/1 IN JRNL TITL 2 COMPLEX WITH BROAD PROTECTIVE ANTIBODY 3E1 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 4.60 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : PHENIX (1.19.2_4158: ???) REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE, REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER, REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY, REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON, REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI, REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART REMARK 3 REMARK 3 REFINEMENT TARGET : ML REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 4.60 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 48.05 REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.330 REMARK 3 COMPLETENESS FOR RANGE (%) : 99.1 REMARK 3 NUMBER OF REFLECTIONS : 42653 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 R VALUE (WORKING + TEST SET) : 0.294 REMARK 3 R VALUE (WORKING SET) : 0.293 REMARK 3 FREE R VALUE : 0.325 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.780 REMARK 3 FREE R VALUE TEST SET COUNT : 2037 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS). REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE REMARK 3 1 48.0500 - 11.3000 0.95 2740 158 0.2535 0.2735 REMARK 3 2 11.3000 - 8.9900 0.99 2762 125 0.2139 0.2607 REMARK 3 3 8.9900 - 7.8600 1.00 2782 107 0.2736 0.2788 REMARK 3 4 7.8600 - 7.1400 1.00 2748 141 0.3221 0.3475 REMARK 3 5 7.1400 - 6.6300 1.00 2733 143 0.3250 0.3723 REMARK 3 6 6.6300 - 6.2400 1.00 2678 165 0.3221 0.3862 REMARK 3 7 6.2400 - 5.9300 1.00 2720 129 0.3341 0.3503 REMARK 3 8 5.9300 - 5.6700 1.00 2714 130 0.3322 0.3951 REMARK 3 9 5.6700 - 5.4500 0.99 2709 118 0.3245 0.3840 REMARK 3 10 5.4500 - 5.2700 1.00 2692 126 0.3173 0.3173 REMARK 3 11 5.2700 - 5.1000 1.00 2705 124 0.3294 0.3583 REMARK 3 12 5.1000 - 4.9600 1.00 2707 131 0.3430 0.3778 REMARK 3 13 4.9600 - 4.8300 1.00 2679 142 0.3493 0.3799 REMARK 3 14 4.8300 - 4.7100 1.00 2674 153 0.3415 0.3703 REMARK 3 15 4.7100 - 4.6000 0.96 2573 145 0.3504 0.3561 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL REMARK 3 SOLVENT RADIUS : 1.11 REMARK 3 SHRINKAGE RADIUS : 0.90 REMARK 3 K_SOL : NULL REMARK 3 B_SOL : NULL REMARK 3 REMARK 3 ERROR ESTIMATES. REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.880 REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 35.070 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : NULL REMARK 3 B22 (A**2) : NULL REMARK 3 B33 (A**2) : NULL REMARK 3 B12 (A**2) : NULL REMARK 3 B13 (A**2) : NULL REMARK 3 B23 (A**2) : NULL REMARK 3 REMARK 3 TWINNING INFORMATION. REMARK 3 FRACTION: NULL REMARK 3 OPERATOR: NULL REMARK 3 REMARK 3 DEVIATIONS FROM IDEAL VALUES. REMARK 3 RMSD COUNT REMARK 3 BOND : 0.004 44263 REMARK 3 ANGLE : 0.748 60111 REMARK 3 CHIRALITY : 0.049 6692 REMARK 3 PLANARITY : 0.006 7698 REMARK 3 DIHEDRAL : 7.672 6084 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 NCS DETAILS REMARK 3 NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 9C22 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 31-MAY-24. REMARK 100 THE DEPOSITION ID IS D_1000284521. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 19-NOV-22 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : NULL REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SSRL REMARK 200 BEAMLINE : BL12-1 REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 1.033 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS EIGER2 X 16M REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000 REMARK 200 DATA SCALING SOFTWARE : HKL-2000 REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 42908 REMARK 200 RESOLUTION RANGE HIGH (A) : 4.600 REMARK 200 RESOLUTION RANGE LOW (A) : 48.050 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 99.8 REMARK 200 DATA REDUNDANCY : 14.40 REMARK 200 R MERGE (I) : NULL REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 4.4000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 4.60 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 4.68 REMARK 200 COMPLETENESS FOR SHELL (%) : NULL REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : NULL REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : NULL REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHENIX REMARK 200 STARTING MODEL: NULL REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 38.02 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.98 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2 M SODIUM PHOSPHATE DIBASIC, 20% REMARK 280 W/V PEG3350, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X+1/2,-Y,Z+1/2 REMARK 290 3555 -X,Y+1/2,-Z+1/2 REMARK 290 4555 X+1/2,-Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 91.21650 REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 107.36650 REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 97.25000 REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 107.36650 REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 91.21650 REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 97.25000 REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1, 2 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, C, D, E, H, I, J, K, L, M, REMARK 350 AND CHAINS: N, Y, A, G, O, T REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 2 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: P, Q, R, S, U, V, W, X, a, b, REMARK 350 AND CHAINS: c, d, F, Z, e REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLY B -326 REMARK 465 ASP B -325 REMARK 465 THR B -324 REMARK 465 LEU B -323 REMARK 465 CYS B -322 REMARK 465 ILE B -321 REMARK 465 GLY B -320 REMARK 465 TYR B -319 REMARK 465 HIS B -318 REMARK 465 ALA B -317 REMARK 465 ASN B -316 REMARK 465 ASN B -315 REMARK 465 SER B -314 REMARK 465 THR B -313 REMARK 465 ASP B -312 REMARK 465 THR B -311 REMARK 465 VAL B -310 REMARK 465 ASP B -309 REMARK 465 THR B -308 REMARK 465 LEU B -307 REMARK 465 LEU B -306 REMARK 465 GLU B -305 REMARK 465 LYS B -304 REMARK 465 ASN B -303 REMARK 465 VAL B -302 REMARK 465 THR B -301 REMARK 465 VAL B -300 REMARK 465 THR B -299 REMARK 465 HIS B -298 REMARK 465 SER B -297 REMARK 465 VAL B -296 REMARK 465 ASN B -295 REMARK 465 LEU B -294 REMARK 465 LEU B -293 REMARK 465 GLU B -292 REMARK 465 ASP B -291 REMARK 465 LYS B -290 REMARK 465 HIS B -289 REMARK 465 ASN B -288 REMARK 465 GLY B -287 REMARK 465 LYS B -286 REMARK 465 LEU B -285 REMARK 465 CYS B -284 REMARK 465 SER B -283 REMARK 465 ILE B -282 REMARK 465 ASN B -281 REMARK 465 GLY B -280 REMARK 465 LYS B -279 REMARK 465 GLN B -278 REMARK 465 PRO B -277 REMARK 465 ILE B -276 REMARK 465 SER B -275 REMARK 465 LEU B -274 REMARK 465 GLY B -273 REMARK 465 ASP B -272 REMARK 465 CYS B -271 REMARK 465 SER B -270 REMARK 465 PHE B -269 REMARK 465 ALA B -268 REMARK 465 GLY B -267 REMARK 465 TRP B -266 REMARK 465 ILE B -265 REMARK 465 LEU B -264 REMARK 465 GLY B -263 REMARK 465 ASN B -262 REMARK 465 PRO B -261 REMARK 465 MET B -260 REMARK 465 CYS B -259 REMARK 465 ASP B -258 REMARK 465 ASP B -257 REMARK 465 LEU B -256 REMARK 465 ILE B -255 REMARK 465 GLY B -254 REMARK 465 LYS B -253 REMARK 465 THR B -252 REMARK 465 SER B -251 REMARK 465 TRP B -250 REMARK 465 SER B -249 REMARK 465 TYR B -248 REMARK 465 ILE B -247 REMARK 465 VAL B -246 REMARK 465 GLU B -245 REMARK 465 LYS B -244 REMARK 465 PRO B -243 REMARK 465 ASN B -242 REMARK 465 PRO B -241 REMARK 465 THR B -240 REMARK 465 ASN B -239 REMARK 465 GLY B -238 REMARK 465 ILE B -237 REMARK 465 CYS B -236 REMARK 465 TYR B -235 REMARK 465 PRO B -234 REMARK 465 GLY B -233 REMARK 465 THR B -232 REMARK 465 LEU B -231 REMARK 465 GLU B -230 REMARK 465 ASP B -229 REMARK 465 GLU B -228 REMARK 465 GLU B -227 REMARK 465 GLU B -226 REMARK 465 LEU B -225 REMARK 465 ARG B -224 REMARK 465 LEU B -223 REMARK 465 LYS B -222 REMARK 465 PHE B -221 REMARK 465 SER B -220 REMARK 465 GLY B -219 REMARK 465 VAL B -218 REMARK 465 LEU B -217 REMARK 465 GLU B -216 REMARK 465 PHE B -215 REMARK 465 SER B -214 REMARK 465 LYS B -213 REMARK 465 PHE B -212 REMARK 465 GLU B -211 REMARK 465 ALA B -210 REMARK 465 PHE B -209 REMARK 465 THR B -208 REMARK 465 SER B -207 REMARK 465 ASN B -206 REMARK 465 GLY B -205 REMARK 465 TRP B -204 REMARK 465 GLY B -203 REMARK 465 ALA B -202 REMARK 465 VAL B -201 REMARK 465 ASN B -200 REMARK 465 SER B -199 REMARK 465 GLY B -198 REMARK 465 ALA B -197 REMARK 465 GLY B -196 REMARK 465 VAL B -195 REMARK 465 THR B -194 REMARK 465 ALA B -193 REMARK 465 ALA B -192 REMARK 465 CYS B -191 REMARK 465 LYS B -190 REMARK 465 PHE B -189 REMARK 465 GLY B -188 REMARK 465 SER B -187 REMARK 465 SER B -186 REMARK 465 ASN B -185 REMARK 465 SER B -184 REMARK 465 PHE B -183 REMARK 465 PHE B -182 REMARK 465 ARG B -181 REMARK 465 ASN B -180 REMARK 465 MET B -179 REMARK 465 VAL B -178 REMARK 465 TRP B -177 REMARK 465 LEU B -176 REMARK 465 ILE B -175 REMARK 465 HIS B -174 REMARK 465 GLN B -173 REMARK 465 SER B -172 REMARK 465 GLY B -171 REMARK 465 THR B -170 REMARK 465 TYR B -169 REMARK 465 PRO B -168 REMARK 465 VAL B -167 REMARK 465 ILE B -166 REMARK 465 LYS B -165 REMARK 465 ARG B -164 REMARK 465 THR B -163 REMARK 465 PHE B -162 REMARK 465 ASN B -161 REMARK 465 ASN B -160 REMARK 465 THR B -159 REMARK 465 LYS B -158 REMARK 465 GLY B -157 REMARK 465 ARG B -156 REMARK 465 ASP B -155 REMARK 465 VAL B -154 REMARK 465 LEU B -153 REMARK 465 ILE B -152 REMARK 465 VAL B -151 REMARK 465 TRP B -150 REMARK 465 GLY B -149 REMARK 465 ILE B -148 REMARK 465 HIS B -147 REMARK 465 HIS B -146 REMARK 465 PRO B -145 REMARK 465 ALA B -144 REMARK 465 THR B -143 REMARK 465 LEU B -142 REMARK 465 LYS B -141 REMARK 465 GLU B -140 REMARK 465 HIS B -139 REMARK 465 GLN B -138 REMARK 465 ASP B -137 REMARK 465 LEU B -136 REMARK 465 TYR B -135 REMARK 465 LYS B -134 REMARK 465 LYS B -133 REMARK 465 ASP B -132 REMARK 465 SER B -131 REMARK 465 SER B -130 REMARK 465 TYR B -129 REMARK 465 VAL B -128 REMARK 465 ALA B -127 REMARK 465 VAL B -126 REMARK 465 GLY B -125 REMARK 465 SER B -124 REMARK 465 GLU B -123 REMARK 465 THR B -122 REMARK 465 TYR B -121 REMARK 465 ASN B -120 REMARK 465 ARG B -119 REMARK 465 ARG B -118 REMARK 465 PHE B -117 REMARK 465 THR B -116 REMARK 465 PRO B -115 REMARK 465 GLU B -114 REMARK 465 ILE B -113 REMARK 465 SER B -112 REMARK 465 THR B -111 REMARK 465 ARG B -110 REMARK 465 PRO B -109 REMARK 465 ASN B -108 REMARK 465 VAL B -107 REMARK 465 ASN B -106 REMARK 465 GLY B -105 REMARK 465 GLN B -104 REMARK 465 ALA B -103 REMARK 465 GLY B -102 REMARK 465 ARG B -101 REMARK 465 MET B -100 REMARK 465 THR B -99 REMARK 465 PHE B -98 REMARK 465 TYR B -97 REMARK 465 TRP B -96 REMARK 465 THR B -95 REMARK 465 MET B -94 REMARK 465 VAL B -93 REMARK 465 LYS B -92 REMARK 465 PRO B -91 REMARK 465 GLY B -90 REMARK 465 GLU B -89 REMARK 465 SER B -88 REMARK 465 ILE B -87 REMARK 465 THR B -86 REMARK 465 PHE B -85 REMARK 465 GLU B -84 REMARK 465 SER B -83 REMARK 465 ASN B -82 REMARK 465 GLY B -81 REMARK 465 ALA B -80 REMARK 465 PHE B -79 REMARK 465 LEU B -78 REMARK 465 ALA B -77 REMARK 465 PRO B -76 REMARK 465 ARG B -75 REMARK 465 TYR B -74 REMARK 465 ALA B -73 REMARK 465 PHE B -72 REMARK 465 GLU B -71 REMARK 465 ILE B -70 REMARK 465 VAL B -69 REMARK 465 SER B -68 REMARK 465 VAL B -67 REMARK 465 GLY B -66 REMARK 465 ASN B -65 REMARK 465 GLY B -64 REMARK 465 LYS B -63 REMARK 465 LEU B -62 REMARK 465 PHE B -61 REMARK 465 ARG B -60 REMARK 465 SER B -59 REMARK 465 GLU B -58 REMARK 465 LEU B -57 REMARK 465 SER B -56 REMARK 465 ILE B -55 REMARK 465 GLU B -54 REMARK 465 SER B -53 REMARK 465 CYS B -52 REMARK 465 ASN B -51 REMARK 465 THR B -50 REMARK 465 THR B -49 REMARK 465 CYS B -48 REMARK 465 GLN B -47 REMARK 465 THR B -46 REMARK 465 PRO B -45 REMARK 465 LYS B -44 REMARK 465 GLY B -43 REMARK 465 ALA B -42 REMARK 465 ILE B -41 REMARK 465 ASN B -40 REMARK 465 THR B -39 REMARK 465 SER B -38 REMARK 465 LEU B -37 REMARK 465 PRO B -36 REMARK 465 PHE B -35 REMARK 465 GLN B -34 REMARK 465 ASN B -33 REMARK 465 ILE B -32 REMARK 465 HIS B -31 REMARK 465 PRO B -30 REMARK 465 ILE B -29 REMARK 465 THR B -28 REMARK 465 ILE B -27 REMARK 465 GLY B -26 REMARK 465 LYS B -25 REMARK 465 CYS B -24 REMARK 465 PRO B -23 REMARK 465 LYS B -22 REMARK 465 TYR B -21 REMARK 465 VAL B -20 REMARK 465 LYS B -19 REMARK 465 SER B -18 REMARK 465 THR B -17 REMARK 465 LYS B -16 REMARK 465 LEU B -15 REMARK 465 ARG B -14 REMARK 465 LEU B -13 REMARK 465 ALA B -12 REMARK 465 THR B -11 REMARK 465 GLY B -10 REMARK 465 LEU B -9 REMARK 465 ARG B -8 REMARK 465 ASN B -7 REMARK 465 VAL B -6 REMARK 465 PRO B -5 REMARK 465 SER B -4 REMARK 465 ILE B -3 REMARK 465 GLN B -2 REMARK 465 SER B -1 REMARK 465 ARG B 0 REMARK 465 GLY B 1 REMARK 465 LEU B 2 REMARK 465 PHE B 3 REMARK 465 GLY B 4 REMARK 465 ALA B 5 REMARK 465 ILE B 6 REMARK 465 SER B 175 REMARK 465 GLY B 176 REMARK 465 ARG B 177 REMARK 465 ILE C 333 REMARK 465 GLN C 334 REMARK 465 SER C 335 REMARK 465 ARG C 336 REMARK 465 GLY C 337 REMARK 465 LEU C 338 REMARK 465 PHE C 339 REMARK 465 GLY C 340 REMARK 465 ALA C 341 REMARK 465 ILE C 342 REMARK 465 ALA C 343 REMARK 465 GLY C 344 REMARK 465 PHE C 345 REMARK 465 ILE C 346 REMARK 465 GLU C 347 REMARK 465 GLY C 348 REMARK 465 GLY C 349 REMARK 465 TRP C 350 REMARK 465 THR C 351 REMARK 465 GLY C 352 REMARK 465 MET C 353 REMARK 465 VAL C 354 REMARK 465 ASP C 355 REMARK 465 GLY C 356 REMARK 465 TRP C 357 REMARK 465 TYR C 358 REMARK 465 GLY C 359 REMARK 465 TYR C 360 REMARK 465 HIS C 361 REMARK 465 HIS C 362 REMARK 465 GLN C 363 REMARK 465 ASN C 364 REMARK 465 GLU C 365 REMARK 465 GLN C 366 REMARK 465 GLY C 367 REMARK 465 SER C 368 REMARK 465 GLY C 369 REMARK 465 TYR C 370 REMARK 465 ALA C 371 REMARK 465 ALA C 372 REMARK 465 ASP C 373 REMARK 465 LEU C 374 REMARK 465 LYS C 375 REMARK 465 SER C 376 REMARK 465 THR C 377 REMARK 465 GLN C 378 REMARK 465 ASN C 379 REMARK 465 ALA C 380 REMARK 465 ILE C 381 REMARK 465 ASP C 382 REMARK 465 GLY C 383 REMARK 465 ILE C 384 REMARK 465 THR C 385 REMARK 465 ASN C 386 REMARK 465 LYS C 387 REMARK 465 VAL C 388 REMARK 465 ASN C 389 REMARK 465 SER C 390 REMARK 465 VAL C 391 REMARK 465 ILE C 392 REMARK 465 GLU C 393 REMARK 465 LYS C 394 REMARK 465 MET C 395 REMARK 465 ASN C 396 REMARK 465 THR C 397 REMARK 465 GLN C 398 REMARK 465 PHE C 399 REMARK 465 THR C 400 REMARK 465 ALA C 401 REMARK 465 VAL C 402 REMARK 465 GLY C 403 REMARK 465 LYS C 404 REMARK 465 GLU C 405 REMARK 465 PHE C 406 REMARK 465 ASN C 407 REMARK 465 HIS C 408 REMARK 465 LEU C 409 REMARK 465 GLU C 410 REMARK 465 LYS C 411 REMARK 465 ARG C 412 REMARK 465 ILE C 413 REMARK 465 GLU C 414 REMARK 465 ASN C 415 REMARK 465 LEU C 416 REMARK 465 ASN C 417 REMARK 465 LYS C 418 REMARK 465 LYS C 419 REMARK 465 VAL C 420 REMARK 465 ASP C 421 REMARK 465 ASP C 422 REMARK 465 GLY C 423 REMARK 465 PHE C 424 REMARK 465 LEU C 425 REMARK 465 ASP C 426 REMARK 465 ILE C 427 REMARK 465 TRP C 428 REMARK 465 THR C 429 REMARK 465 TYR C 430 REMARK 465 ASN C 431 REMARK 465 ALA C 432 REMARK 465 GLU C 433 REMARK 465 LEU C 434 REMARK 465 LEU C 435 REMARK 465 VAL C 436 REMARK 465 LEU C 437 REMARK 465 LEU C 438 REMARK 465 GLU C 439 REMARK 465 ASN C 440 REMARK 465 GLU C 441 REMARK 465 ARG C 442 REMARK 465 THR C 443 REMARK 465 LEU C 444 REMARK 465 ASP C 445 REMARK 465 TYR C 446 REMARK 465 HIS C 447 REMARK 465 ASP C 448 REMARK 465 SER C 449 REMARK 465 ASN C 450 REMARK 465 VAL C 451 REMARK 465 LYS C 452 REMARK 465 ASN C 453 REMARK 465 LEU C 454 REMARK 465 TYR C 455 REMARK 465 GLU C 456 REMARK 465 LYS C 457 REMARK 465 VAL C 458 REMARK 465 ARG C 459 REMARK 465 SER C 460 REMARK 465 GLN C 461 REMARK 465 LEU C 462 REMARK 465 LYS C 463 REMARK 465 ASN C 464 REMARK 465 ASN C 465 REMARK 465 ALA C 466 REMARK 465 LYS C 467 REMARK 465 GLU C 468 REMARK 465 ILE C 469 REMARK 465 GLY C 470 REMARK 465 ASN C 471 REMARK 465 GLY C 472 REMARK 465 CYS C 473 REMARK 465 PHE C 474 REMARK 465 GLU C 475 REMARK 465 PHE C 476 REMARK 465 TYR C 477 REMARK 465 HIS C 478 REMARK 465 LYS C 479 REMARK 465 CYS C 480 REMARK 465 ASP C 481 REMARK 465 ASN C 482 REMARK 465 THR C 483 REMARK 465 CYS C 484 REMARK 465 MET C 485 REMARK 465 GLU C 486 REMARK 465 SER C 487 REMARK 465 VAL C 488 REMARK 465 LYS C 489 REMARK 465 ASN C 490 REMARK 465 GLY C 491 REMARK 465 THR C 492 REMARK 465 TYR C 493 REMARK 465 ASP C 494 REMARK 465 TYR C 495 REMARK 465 PRO C 496 REMARK 465 LYS C 497 REMARK 465 TYR C 498 REMARK 465 SER C 499 REMARK 465 GLU C 500 REMARK 465 GLU C 501 REMARK 465 ALA C 502 REMARK 465 LYS C 503 REMARK 465 LEU C 504 REMARK 465 ASN C 505 REMARK 465 ARG C 506 REMARK 465 GLU C 507 REMARK 465 GLU C 508 REMARK 465 ILE C 509 REMARK 465 ASP C 510 REMARK 465 SER C 511 REMARK 465 GLY C 512 REMARK 465 ARG C 513 REMARK 465 GLU D 213 REMARK 465 CYS D 214 REMARK 465 LYS E 222 REMARK 465 SER E 223 REMARK 465 CYS E 224 REMARK 465 GLY H -326 REMARK 465 ASP H -325 REMARK 465 THR H -324 REMARK 465 LEU H -323 REMARK 465 CYS H -322 REMARK 465 ILE H -321 REMARK 465 GLY H -320 REMARK 465 TYR H -319 REMARK 465 HIS H -318 REMARK 465 ALA H -317 REMARK 465 ASN H -316 REMARK 465 ASN H -315 REMARK 465 SER H -314 REMARK 465 THR H -313 REMARK 465 ASP H -312 REMARK 465 THR H -311 REMARK 465 VAL H -310 REMARK 465 ASP H -309 REMARK 465 THR H -308 REMARK 465 LEU H -307 REMARK 465 LEU H -306 REMARK 465 GLU H -305 REMARK 465 LYS H -304 REMARK 465 ASN H -303 REMARK 465 VAL H -302 REMARK 465 THR H -301 REMARK 465 VAL H -300 REMARK 465 THR H -299 REMARK 465 HIS H -298 REMARK 465 SER H -297 REMARK 465 VAL H -296 REMARK 465 ASN H -295 REMARK 465 LEU H -294 REMARK 465 LEU H -293 REMARK 465 GLU H -292 REMARK 465 ASP H -291 REMARK 465 LYS H -290 REMARK 465 HIS H -289 REMARK 465 ASN H -288 REMARK 465 GLY H -287 REMARK 465 LYS H -286 REMARK 465 LEU H -285 REMARK 465 CYS H -284 REMARK 465 SER H -283 REMARK 465 ILE H -282 REMARK 465 ASN H -281 REMARK 465 GLY H -280 REMARK 465 LYS H -279 REMARK 465 GLN H -278 REMARK 465 PRO H -277 REMARK 465 ILE H -276 REMARK 465 SER H -275 REMARK 465 LEU H -274 REMARK 465 GLY H -273 REMARK 465 ASP H -272 REMARK 465 CYS H -271 REMARK 465 SER H -270 REMARK 465 PHE H -269 REMARK 465 ALA H -268 REMARK 465 GLY H -267 REMARK 465 TRP H -266 REMARK 465 ILE H -265 REMARK 465 LEU H -264 REMARK 465 GLY H -263 REMARK 465 ASN H -262 REMARK 465 PRO H -261 REMARK 465 MET H -260 REMARK 465 CYS H -259 REMARK 465 ASP H -258 REMARK 465 ASP H -257 REMARK 465 LEU H -256 REMARK 465 ILE H -255 REMARK 465 GLY H -254 REMARK 465 LYS H -253 REMARK 465 THR H -252 REMARK 465 SER H -251 REMARK 465 TRP H -250 REMARK 465 SER H -249 REMARK 465 TYR H -248 REMARK 465 ILE H -247 REMARK 465 VAL H -246 REMARK 465 GLU H -245 REMARK 465 LYS H -244 REMARK 465 PRO H -243 REMARK 465 ASN H -242 REMARK 465 PRO H -241 REMARK 465 THR H -240 REMARK 465 ASN H -239 REMARK 465 GLY H -238 REMARK 465 ILE H -237 REMARK 465 CYS H -236 REMARK 465 TYR H -235 REMARK 465 PRO H -234 REMARK 465 GLY H -233 REMARK 465 THR H -232 REMARK 465 LEU H -231 REMARK 465 GLU H -230 REMARK 465 ASP H -229 REMARK 465 GLU H -228 REMARK 465 GLU H -227 REMARK 465 GLU H -226 REMARK 465 LEU H -225 REMARK 465 ARG H -224 REMARK 465 LEU H -223 REMARK 465 LYS H -222 REMARK 465 PHE H -221 REMARK 465 SER H -220 REMARK 465 GLY H -219 REMARK 465 VAL H -218 REMARK 465 LEU H -217 REMARK 465 GLU H -216 REMARK 465 PHE H -215 REMARK 465 SER H -214 REMARK 465 LYS H -213 REMARK 465 PHE H -212 REMARK 465 GLU H -211 REMARK 465 ALA H -210 REMARK 465 PHE H -209 REMARK 465 THR H -208 REMARK 465 SER H -207 REMARK 465 ASN H -206 REMARK 465 GLY H -205 REMARK 465 TRP H -204 REMARK 465 GLY H -203 REMARK 465 ALA H -202 REMARK 465 VAL H -201 REMARK 465 ASN H -200 REMARK 465 SER H -199 REMARK 465 GLY H -198 REMARK 465 ALA H -197 REMARK 465 GLY H -196 REMARK 465 VAL H -195 REMARK 465 THR H -194 REMARK 465 ALA H -193 REMARK 465 ALA H -192 REMARK 465 CYS H -191 REMARK 465 LYS H -190 REMARK 465 PHE H -189 REMARK 465 GLY H -188 REMARK 465 SER H -187 REMARK 465 SER H -186 REMARK 465 ASN H -185 REMARK 465 SER H -184 REMARK 465 PHE H -183 REMARK 465 PHE H -182 REMARK 465 ARG H -181 REMARK 465 ASN H -180 REMARK 465 MET H -179 REMARK 465 VAL H -178 REMARK 465 TRP H -177 REMARK 465 LEU H -176 REMARK 465 ILE H -175 REMARK 465 HIS H -174 REMARK 465 GLN H -173 REMARK 465 SER H -172 REMARK 465 GLY H -171 REMARK 465 THR H -170 REMARK 465 TYR H -169 REMARK 465 PRO H -168 REMARK 465 VAL H -167 REMARK 465 ILE H -166 REMARK 465 LYS H -165 REMARK 465 ARG H -164 REMARK 465 THR H -163 REMARK 465 PHE H -162 REMARK 465 ASN H -161 REMARK 465 ASN H -160 REMARK 465 THR H -159 REMARK 465 LYS H -158 REMARK 465 GLY H -157 REMARK 465 ARG H -156 REMARK 465 ASP H -155 REMARK 465 VAL H -154 REMARK 465 LEU H -153 REMARK 465 ILE H -152 REMARK 465 VAL H -151 REMARK 465 TRP H -150 REMARK 465 GLY H -149 REMARK 465 ILE H -148 REMARK 465 HIS H -147 REMARK 465 HIS H -146 REMARK 465 PRO H -145 REMARK 465 ALA H -144 REMARK 465 THR H -143 REMARK 465 LEU H -142 REMARK 465 LYS H -141 REMARK 465 GLU H -140 REMARK 465 HIS H -139 REMARK 465 GLN H -138 REMARK 465 ASP H -137 REMARK 465 LEU H -136 REMARK 465 TYR H -135 REMARK 465 LYS H -134 REMARK 465 LYS H -133 REMARK 465 ASP H -132 REMARK 465 SER H -131 REMARK 465 SER H -130 REMARK 465 TYR H -129 REMARK 465 VAL H -128 REMARK 465 ALA H -127 REMARK 465 VAL H -126 REMARK 465 GLY H -125 REMARK 465 SER H -124 REMARK 465 GLU H -123 REMARK 465 THR H -122 REMARK 465 TYR H -121 REMARK 465 ASN H -120 REMARK 465 ARG H -119 REMARK 465 ARG H -118 REMARK 465 PHE H -117 REMARK 465 THR H -116 REMARK 465 PRO H -115 REMARK 465 GLU H -114 REMARK 465 ILE H -113 REMARK 465 SER H -112 REMARK 465 THR H -111 REMARK 465 ARG H -110 REMARK 465 PRO H -109 REMARK 465 ASN H -108 REMARK 465 VAL H -107 REMARK 465 ASN H -106 REMARK 465 GLY H -105 REMARK 465 GLN H -104 REMARK 465 ALA H -103 REMARK 465 GLY H -102 REMARK 465 ARG H -101 REMARK 465 MET H -100 REMARK 465 THR H -99 REMARK 465 PHE H -98 REMARK 465 TYR H -97 REMARK 465 TRP H -96 REMARK 465 THR H -95 REMARK 465 MET H -94 REMARK 465 VAL H -93 REMARK 465 LYS H -92 REMARK 465 PRO H -91 REMARK 465 GLY H -90 REMARK 465 GLU H -89 REMARK 465 SER H -88 REMARK 465 ILE H -87 REMARK 465 THR H -86 REMARK 465 PHE H -85 REMARK 465 GLU H -84 REMARK 465 SER H -83 REMARK 465 ASN H -82 REMARK 465 GLY H -81 REMARK 465 ALA H -80 REMARK 465 PHE H -79 REMARK 465 LEU H -78 REMARK 465 ALA H -77 REMARK 465 PRO H -76 REMARK 465 ARG H -75 REMARK 465 TYR H -74 REMARK 465 ALA H -73 REMARK 465 PHE H -72 REMARK 465 GLU H -71 REMARK 465 ILE H -70 REMARK 465 VAL H -69 REMARK 465 SER H -68 REMARK 465 VAL H -67 REMARK 465 GLY H -66 REMARK 465 ASN H -65 REMARK 465 GLY H -64 REMARK 465 LYS H -63 REMARK 465 LEU H -62 REMARK 465 PHE H -61 REMARK 465 ARG H -60 REMARK 465 SER H -59 REMARK 465 GLU H -58 REMARK 465 LEU H -57 REMARK 465 SER H -56 REMARK 465 ILE H -55 REMARK 465 GLU H -54 REMARK 465 SER H -53 REMARK 465 CYS H -52 REMARK 465 ASN H -51 REMARK 465 THR H -50 REMARK 465 THR H -49 REMARK 465 CYS H -48 REMARK 465 GLN H -47 REMARK 465 THR H -46 REMARK 465 PRO H -45 REMARK 465 LYS H -44 REMARK 465 GLY H -43 REMARK 465 ALA H -42 REMARK 465 ILE H -41 REMARK 465 ASN H -40 REMARK 465 THR H -39 REMARK 465 SER H -38 REMARK 465 LEU H -37 REMARK 465 PRO H -36 REMARK 465 PHE H -35 REMARK 465 GLN H -34 REMARK 465 ASN H -33 REMARK 465 ILE H -32 REMARK 465 HIS H -31 REMARK 465 PRO H -30 REMARK 465 ILE H -29 REMARK 465 THR H -28 REMARK 465 ILE H -27 REMARK 465 GLY H -26 REMARK 465 LYS H -25 REMARK 465 CYS H -24 REMARK 465 PRO H -23 REMARK 465 LYS H -22 REMARK 465 TYR H -21 REMARK 465 VAL H -20 REMARK 465 LYS H -19 REMARK 465 SER H -18 REMARK 465 THR H -17 REMARK 465 LYS H -16 REMARK 465 LEU H -15 REMARK 465 ARG H -14 REMARK 465 LEU H -13 REMARK 465 ALA H -12 REMARK 465 THR H -11 REMARK 465 GLY H -10 REMARK 465 LEU H -9 REMARK 465 ARG H -8 REMARK 465 ASN H -7 REMARK 465 VAL H -6 REMARK 465 PRO H -5 REMARK 465 SER H -4 REMARK 465 ILE H -3 REMARK 465 GLN H -2 REMARK 465 SER H -1 REMARK 465 ARG H 0 REMARK 465 GLY H 1 REMARK 465 LEU H 2 REMARK 465 PHE H 3 REMARK 465 GLY H 4 REMARK 465 ALA H 5 REMARK 465 ILE H 6 REMARK 465 SER H 175 REMARK 465 GLY H 176 REMARK 465 ARG H 177 REMARK 465 GLY I -326 REMARK 465 ASP I -325 REMARK 465 THR I -324 REMARK 465 LEU I -323 REMARK 465 CYS I -322 REMARK 465 ILE I -321 REMARK 465 GLY I -320 REMARK 465 TYR I -319 REMARK 465 HIS I -318 REMARK 465 ALA I -317 REMARK 465 ASN I -316 REMARK 465 ASN I -315 REMARK 465 SER I -314 REMARK 465 THR I -313 REMARK 465 ASP I -312 REMARK 465 THR I -311 REMARK 465 VAL I -310 REMARK 465 ASP I -309 REMARK 465 THR I -308 REMARK 465 LEU I -307 REMARK 465 LEU I -306 REMARK 465 GLU I -305 REMARK 465 LYS I -304 REMARK 465 ASN I -303 REMARK 465 VAL I -302 REMARK 465 THR I -301 REMARK 465 VAL I -300 REMARK 465 THR I -299 REMARK 465 HIS I -298 REMARK 465 SER I -297 REMARK 465 VAL I -296 REMARK 465 ASN I -295 REMARK 465 LEU I -294 REMARK 465 LEU I -293 REMARK 465 GLU I -292 REMARK 465 ASP I -291 REMARK 465 LYS I -290 REMARK 465 HIS I -289 REMARK 465 ASN I -288 REMARK 465 GLY I -287 REMARK 465 LYS I -286 REMARK 465 LEU I -285 REMARK 465 CYS I -284 REMARK 465 SER I -283 REMARK 465 ILE I -282 REMARK 465 ASN I -281 REMARK 465 GLY I -280 REMARK 465 LYS I -279 REMARK 465 GLN I -278 REMARK 465 PRO I -277 REMARK 465 ILE I -276 REMARK 465 SER I -275 REMARK 465 LEU I -274 REMARK 465 GLY I -273 REMARK 465 ASP I -272 REMARK 465 CYS I -271 REMARK 465 SER I -270 REMARK 465 PHE I -269 REMARK 465 ALA I -268 REMARK 465 GLY I -267 REMARK 465 TRP I -266 REMARK 465 ILE I -265 REMARK 465 LEU I -264 REMARK 465 GLY I -263 REMARK 465 ASN I -262 REMARK 465 PRO I -261 REMARK 465 MET I -260 REMARK 465 CYS I -259 REMARK 465 ASP I -258 REMARK 465 ASP I -257 REMARK 465 LEU I -256 REMARK 465 ILE I -255 REMARK 465 GLY I -254 REMARK 465 LYS I -253 REMARK 465 THR I -252 REMARK 465 SER I -251 REMARK 465 TRP I -250 REMARK 465 SER I -249 REMARK 465 TYR I -248 REMARK 465 ILE I -247 REMARK 465 VAL I -246 REMARK 465 GLU I -245 REMARK 465 LYS I -244 REMARK 465 PRO I -243 REMARK 465 ASN I -242 REMARK 465 PRO I -241 REMARK 465 THR I -240 REMARK 465 ASN I -239 REMARK 465 GLY I -238 REMARK 465 ILE I -237 REMARK 465 CYS I -236 REMARK 465 TYR I -235 REMARK 465 PRO I -234 REMARK 465 GLY I -233 REMARK 465 THR I -232 REMARK 465 LEU I -231 REMARK 465 GLU I -230 REMARK 465 ASP I -229 REMARK 465 GLU I -228 REMARK 465 GLU I -227 REMARK 465 GLU I -226 REMARK 465 LEU I -225 REMARK 465 ARG I -224 REMARK 465 LEU I -223 REMARK 465 LYS I -222 REMARK 465 PHE I -221 REMARK 465 SER I -220 REMARK 465 GLY I -219 REMARK 465 VAL I -218 REMARK 465 LEU I -217 REMARK 465 GLU I -216 REMARK 465 PHE I -215 REMARK 465 SER I -214 REMARK 465 LYS I -213 REMARK 465 PHE I -212 REMARK 465 GLU I -211 REMARK 465 ALA I -210 REMARK 465 PHE I -209 REMARK 465 THR I -208 REMARK 465 SER I -207 REMARK 465 ASN I -206 REMARK 465 GLY I -205 REMARK 465 TRP I -204 REMARK 465 GLY I -203 REMARK 465 ALA I -202 REMARK 465 VAL I -201 REMARK 465 ASN I -200 REMARK 465 SER I -199 REMARK 465 GLY I -198 REMARK 465 ALA I -197 REMARK 465 GLY I -196 REMARK 465 VAL I -195 REMARK 465 THR I -194 REMARK 465 ALA I -193 REMARK 465 ALA I -192 REMARK 465 CYS I -191 REMARK 465 LYS I -190 REMARK 465 PHE I -189 REMARK 465 GLY I -188 REMARK 465 SER I -187 REMARK 465 SER I -186 REMARK 465 ASN I -185 REMARK 465 SER I -184 REMARK 465 PHE I -183 REMARK 465 PHE I -182 REMARK 465 ARG I -181 REMARK 465 ASN I -180 REMARK 465 MET I -179 REMARK 465 VAL I -178 REMARK 465 TRP I -177 REMARK 465 LEU I -176 REMARK 465 ILE I -175 REMARK 465 HIS I -174 REMARK 465 GLN I -173 REMARK 465 SER I -172 REMARK 465 GLY I -171 REMARK 465 THR I -170 REMARK 465 TYR I -169 REMARK 465 PRO I -168 REMARK 465 VAL I -167 REMARK 465 ILE I -166 REMARK 465 LYS I -165 REMARK 465 ARG I -164 REMARK 465 THR I -163 REMARK 465 PHE I -162 REMARK 465 ASN I -161 REMARK 465 ASN I -160 REMARK 465 THR I -159 REMARK 465 LYS I -158 REMARK 465 GLY I -157 REMARK 465 ARG I -156 REMARK 465 ASP I -155 REMARK 465 VAL I -154 REMARK 465 LEU I -153 REMARK 465 ILE I -152 REMARK 465 VAL I -151 REMARK 465 TRP I -150 REMARK 465 GLY I -149 REMARK 465 ILE I -148 REMARK 465 HIS I -147 REMARK 465 HIS I -146 REMARK 465 PRO I -145 REMARK 465 ALA I -144 REMARK 465 THR I -143 REMARK 465 LEU I -142 REMARK 465 LYS I -141 REMARK 465 GLU I -140 REMARK 465 HIS I -139 REMARK 465 GLN I -138 REMARK 465 ASP I -137 REMARK 465 LEU I -136 REMARK 465 TYR I -135 REMARK 465 LYS I -134 REMARK 465 LYS I -133 REMARK 465 ASP I -132 REMARK 465 SER I -131 REMARK 465 SER I -130 REMARK 465 TYR I -129 REMARK 465 VAL I -128 REMARK 465 ALA I -127 REMARK 465 VAL I -126 REMARK 465 GLY I -125 REMARK 465 SER I -124 REMARK 465 GLU I -123 REMARK 465 THR I -122 REMARK 465 TYR I -121 REMARK 465 ASN I -120 REMARK 465 ARG I -119 REMARK 465 ARG I -118 REMARK 465 PHE I -117 REMARK 465 THR I -116 REMARK 465 PRO I -115 REMARK 465 GLU I -114 REMARK 465 ILE I -113 REMARK 465 SER I -112 REMARK 465 THR I -111 REMARK 465 ARG I -110 REMARK 465 PRO I -109 REMARK 465 ASN I -108 REMARK 465 VAL I -107 REMARK 465 ASN I -106 REMARK 465 GLY I -105 REMARK 465 GLN I -104 REMARK 465 ALA I -103 REMARK 465 GLY I -102 REMARK 465 ARG I -101 REMARK 465 MET I -100 REMARK 465 THR I -99 REMARK 465 PHE I -98 REMARK 465 TYR I -97 REMARK 465 TRP I -96 REMARK 465 THR I -95 REMARK 465 MET I -94 REMARK 465 VAL I -93 REMARK 465 LYS I -92 REMARK 465 PRO I -91 REMARK 465 GLY I -90 REMARK 465 GLU I -89 REMARK 465 SER I -88 REMARK 465 ILE I -87 REMARK 465 THR I -86 REMARK 465 PHE I -85 REMARK 465 GLU I -84 REMARK 465 SER I -83 REMARK 465 ASN I -82 REMARK 465 GLY I -81 REMARK 465 ALA I -80 REMARK 465 PHE I -79 REMARK 465 LEU I -78 REMARK 465 ALA I -77 REMARK 465 PRO I -76 REMARK 465 ARG I -75 REMARK 465 TYR I -74 REMARK 465 ALA I -73 REMARK 465 PHE I -72 REMARK 465 GLU I -71 REMARK 465 ILE I -70 REMARK 465 VAL I -69 REMARK 465 SER I -68 REMARK 465 VAL I -67 REMARK 465 GLY I -66 REMARK 465 ASN I -65 REMARK 465 GLY I -64 REMARK 465 LYS I -63 REMARK 465 LEU I -62 REMARK 465 PHE I -61 REMARK 465 ARG I -60 REMARK 465 SER I -59 REMARK 465 GLU I -58 REMARK 465 LEU I -57 REMARK 465 SER I -56 REMARK 465 ILE I -55 REMARK 465 GLU I -54 REMARK 465 SER I -53 REMARK 465 CYS I -52 REMARK 465 ASN I -51 REMARK 465 THR I -50 REMARK 465 THR I -49 REMARK 465 CYS I -48 REMARK 465 GLN I -47 REMARK 465 THR I -46 REMARK 465 PRO I -45 REMARK 465 LYS I -44 REMARK 465 GLY I -43 REMARK 465 ALA I -42 REMARK 465 ILE I -41 REMARK 465 ASN I -40 REMARK 465 THR I -39 REMARK 465 SER I -38 REMARK 465 LEU I -37 REMARK 465 PRO I -36 REMARK 465 PHE I -35 REMARK 465 GLN I -34 REMARK 465 ASN I -33 REMARK 465 ILE I -32 REMARK 465 HIS I -31 REMARK 465 PRO I -30 REMARK 465 ILE I -29 REMARK 465 THR I -28 REMARK 465 ILE I -27 REMARK 465 GLY I -26 REMARK 465 LYS I -25 REMARK 465 CYS I -24 REMARK 465 PRO I -23 REMARK 465 LYS I -22 REMARK 465 TYR I -21 REMARK 465 VAL I -20 REMARK 465 LYS I -19 REMARK 465 SER I -18 REMARK 465 THR I -17 REMARK 465 LYS I -16 REMARK 465 LEU I -15 REMARK 465 ARG I -14 REMARK 465 LEU I -13 REMARK 465 ALA I -12 REMARK 465 THR I -11 REMARK 465 GLY I -10 REMARK 465 LEU I -9 REMARK 465 ARG I -8 REMARK 465 ASN I -7 REMARK 465 VAL I -6 REMARK 465 PRO I -5 REMARK 465 SER I -4 REMARK 465 ILE I -3 REMARK 465 GLN I -2 REMARK 465 SER I -1 REMARK 465 ARG I 0 REMARK 465 GLY I 1 REMARK 465 LEU I 2 REMARK 465 PHE I 3 REMARK 465 GLY I 4 REMARK 465 ALA I 5 REMARK 465 ILE I 6 REMARK 465 SER I 175 REMARK 465 GLY I 176 REMARK 465 ARG I 177 REMARK 465 GLU J 213 REMARK 465 CYS J 214 REMARK 465 LYS K 222 REMARK 465 SER K 223 REMARK 465 CYS K 224 REMARK 465 ILE L 333 REMARK 465 GLN L 334 REMARK 465 SER L 335 REMARK 465 ARG L 336 REMARK 465 GLY L 337 REMARK 465 LEU L 338 REMARK 465 PHE L 339 REMARK 465 GLY L 340 REMARK 465 ALA L 341 REMARK 465 ILE L 342 REMARK 465 ALA L 343 REMARK 465 GLY L 344 REMARK 465 PHE L 345 REMARK 465 ILE L 346 REMARK 465 GLU L 347 REMARK 465 GLY L 348 REMARK 465 GLY L 349 REMARK 465 TRP L 350 REMARK 465 THR L 351 REMARK 465 GLY L 352 REMARK 465 MET L 353 REMARK 465 VAL L 354 REMARK 465 ASP L 355 REMARK 465 GLY L 356 REMARK 465 TRP L 357 REMARK 465 TYR L 358 REMARK 465 GLY L 359 REMARK 465 TYR L 360 REMARK 465 HIS L 361 REMARK 465 HIS L 362 REMARK 465 GLN L 363 REMARK 465 ASN L 364 REMARK 465 GLU L 365 REMARK 465 GLN L 366 REMARK 465 GLY L 367 REMARK 465 SER L 368 REMARK 465 GLY L 369 REMARK 465 TYR L 370 REMARK 465 ALA L 371 REMARK 465 ALA L 372 REMARK 465 ASP L 373 REMARK 465 LEU L 374 REMARK 465 LYS L 375 REMARK 465 SER L 376 REMARK 465 THR L 377 REMARK 465 GLN L 378 REMARK 465 ASN L 379 REMARK 465 ALA L 380 REMARK 465 ILE L 381 REMARK 465 ASP L 382 REMARK 465 GLY L 383 REMARK 465 ILE L 384 REMARK 465 THR L 385 REMARK 465 ASN L 386 REMARK 465 LYS L 387 REMARK 465 VAL L 388 REMARK 465 ASN L 389 REMARK 465 SER L 390 REMARK 465 VAL L 391 REMARK 465 ILE L 392 REMARK 465 GLU L 393 REMARK 465 LYS L 394 REMARK 465 MET L 395 REMARK 465 ASN L 396 REMARK 465 THR L 397 REMARK 465 GLN L 398 REMARK 465 PHE L 399 REMARK 465 THR L 400 REMARK 465 ALA L 401 REMARK 465 VAL L 402 REMARK 465 GLY L 403 REMARK 465 LYS L 404 REMARK 465 GLU L 405 REMARK 465 PHE L 406 REMARK 465 ASN L 407 REMARK 465 HIS L 408 REMARK 465 LEU L 409 REMARK 465 GLU L 410 REMARK 465 LYS L 411 REMARK 465 ARG L 412 REMARK 465 ILE L 413 REMARK 465 GLU L 414 REMARK 465 ASN L 415 REMARK 465 LEU L 416 REMARK 465 ASN L 417 REMARK 465 LYS L 418 REMARK 465 LYS L 419 REMARK 465 VAL L 420 REMARK 465 ASP L 421 REMARK 465 ASP L 422 REMARK 465 GLY L 423 REMARK 465 PHE L 424 REMARK 465 LEU L 425 REMARK 465 ASP L 426 REMARK 465 ILE L 427 REMARK 465 TRP L 428 REMARK 465 THR L 429 REMARK 465 TYR L 430 REMARK 465 ASN L 431 REMARK 465 ALA L 432 REMARK 465 GLU L 433 REMARK 465 LEU L 434 REMARK 465 LEU L 435 REMARK 465 VAL L 436 REMARK 465 LEU L 437 REMARK 465 LEU L 438 REMARK 465 GLU L 439 REMARK 465 ASN L 440 REMARK 465 GLU L 441 REMARK 465 ARG L 442 REMARK 465 THR L 443 REMARK 465 LEU L 444 REMARK 465 ASP L 445 REMARK 465 TYR L 446 REMARK 465 HIS L 447 REMARK 465 ASP L 448 REMARK 465 SER L 449 REMARK 465 ASN L 450 REMARK 465 VAL L 451 REMARK 465 LYS L 452 REMARK 465 ASN L 453 REMARK 465 LEU L 454 REMARK 465 TYR L 455 REMARK 465 GLU L 456 REMARK 465 LYS L 457 REMARK 465 VAL L 458 REMARK 465 ARG L 459 REMARK 465 SER L 460 REMARK 465 GLN L 461 REMARK 465 LEU L 462 REMARK 465 LYS L 463 REMARK 465 ASN L 464 REMARK 465 ASN L 465 REMARK 465 ALA L 466 REMARK 465 LYS L 467 REMARK 465 GLU L 468 REMARK 465 ILE L 469 REMARK 465 GLY L 470 REMARK 465 ASN L 471 REMARK 465 GLY L 472 REMARK 465 CYS L 473 REMARK 465 PHE L 474 REMARK 465 GLU L 475 REMARK 465 PHE L 476 REMARK 465 TYR L 477 REMARK 465 HIS L 478 REMARK 465 LYS L 479 REMARK 465 CYS L 480 REMARK 465 ASP L 481 REMARK 465 ASN L 482 REMARK 465 THR L 483 REMARK 465 CYS L 484 REMARK 465 MET L 485 REMARK 465 GLU L 486 REMARK 465 SER L 487 REMARK 465 VAL L 488 REMARK 465 LYS L 489 REMARK 465 ASN L 490 REMARK 465 GLY L 491 REMARK 465 THR L 492 REMARK 465 TYR L 493 REMARK 465 ASP L 494 REMARK 465 TYR L 495 REMARK 465 PRO L 496 REMARK 465 LYS L 497 REMARK 465 TYR L 498 REMARK 465 SER L 499 REMARK 465 GLU L 500 REMARK 465 GLU L 501 REMARK 465 ALA L 502 REMARK 465 LYS L 503 REMARK 465 LEU L 504 REMARK 465 ASN L 505 REMARK 465 ARG L 506 REMARK 465 GLU L 507 REMARK 465 GLU L 508 REMARK 465 ILE L 509 REMARK 465 ASP L 510 REMARK 465 SER L 511 REMARK 465 GLY L 512 REMARK 465 ARG L 513 REMARK 465 GLU M 213 REMARK 465 CYS M 214 REMARK 465 LYS N 222 REMARK 465 SER N 223 REMARK 465 CYS N 224 REMARK 465 GLY P -326 REMARK 465 ASP P -325 REMARK 465 THR P -324 REMARK 465 LEU P -323 REMARK 465 CYS P -322 REMARK 465 ILE P -321 REMARK 465 GLY P -320 REMARK 465 TYR P -319 REMARK 465 HIS P -318 REMARK 465 ALA P -317 REMARK 465 ASN P -316 REMARK 465 ASN P -315 REMARK 465 SER P -314 REMARK 465 THR P -313 REMARK 465 ASP P -312 REMARK 465 THR P -311 REMARK 465 VAL P -310 REMARK 465 ASP P -309 REMARK 465 THR P -308 REMARK 465 LEU P -307 REMARK 465 LEU P -306 REMARK 465 GLU P -305 REMARK 465 LYS P -304 REMARK 465 ASN P -303 REMARK 465 VAL P -302 REMARK 465 THR P -301 REMARK 465 VAL P -300 REMARK 465 THR P -299 REMARK 465 HIS P -298 REMARK 465 SER P -297 REMARK 465 VAL P -296 REMARK 465 ASN P -295 REMARK 465 LEU P -294 REMARK 465 LEU P -293 REMARK 465 GLU P -292 REMARK 465 ASP P -291 REMARK 465 LYS P -290 REMARK 465 HIS P -289 REMARK 465 ASN P -288 REMARK 465 GLY P -287 REMARK 465 LYS P -286 REMARK 465 LEU P -285 REMARK 465 CYS P -284 REMARK 465 SER P -283 REMARK 465 ILE P -282 REMARK 465 ASN P -281 REMARK 465 GLY P -280 REMARK 465 LYS P -279 REMARK 465 GLN P -278 REMARK 465 PRO P -277 REMARK 465 ILE P -276 REMARK 465 SER P -275 REMARK 465 LEU P -274 REMARK 465 GLY P -273 REMARK 465 ASP P -272 REMARK 465 CYS P -271 REMARK 465 SER P -270 REMARK 465 PHE P -269 REMARK 465 ALA P -268 REMARK 465 GLY P -267 REMARK 465 TRP P -266 REMARK 465 ILE P -265 REMARK 465 LEU P -264 REMARK 465 GLY P -263 REMARK 465 ASN P -262 REMARK 465 PRO P -261 REMARK 465 MET P -260 REMARK 465 CYS P -259 REMARK 465 ASP P -258 REMARK 465 ASP P -257 REMARK 465 LEU P -256 REMARK 465 ILE P -255 REMARK 465 GLY P -254 REMARK 465 LYS P -253 REMARK 465 THR P -252 REMARK 465 SER P -251 REMARK 465 TRP P -250 REMARK 465 SER P -249 REMARK 465 TYR P -248 REMARK 465 ILE P -247 REMARK 465 VAL P -246 REMARK 465 GLU P -245 REMARK 465 LYS P -244 REMARK 465 PRO P -243 REMARK 465 ASN P -242 REMARK 465 PRO P -241 REMARK 465 THR P -240 REMARK 465 ASN P -239 REMARK 465 GLY P -238 REMARK 465 ILE P -237 REMARK 465 CYS P -236 REMARK 465 TYR P -235 REMARK 465 PRO P -234 REMARK 465 GLY P -233 REMARK 465 THR P -232 REMARK 465 LEU P -231 REMARK 465 GLU P -230 REMARK 465 ASP P -229 REMARK 465 GLU P -228 REMARK 465 GLU P -227 REMARK 465 GLU P -226 REMARK 465 LEU P -225 REMARK 465 ARG P -224 REMARK 465 LEU P -223 REMARK 465 LYS P -222 REMARK 465 PHE P -221 REMARK 465 SER P -220 REMARK 465 GLY P -219 REMARK 465 VAL P -218 REMARK 465 LEU P -217 REMARK 465 GLU P -216 REMARK 465 PHE P -215 REMARK 465 SER P -214 REMARK 465 LYS P -213 REMARK 465 PHE P -212 REMARK 465 GLU P -211 REMARK 465 ALA P -210 REMARK 465 PHE P -209 REMARK 465 THR P -208 REMARK 465 SER P -207 REMARK 465 ASN P -206 REMARK 465 GLY P -205 REMARK 465 TRP P -204 REMARK 465 GLY P -203 REMARK 465 ALA P -202 REMARK 465 VAL P -201 REMARK 465 ASN P -200 REMARK 465 SER P -199 REMARK 465 GLY P -198 REMARK 465 ALA P -197 REMARK 465 GLY P -196 REMARK 465 VAL P -195 REMARK 465 THR P -194 REMARK 465 ALA P -193 REMARK 465 ALA P -192 REMARK 465 CYS P -191 REMARK 465 LYS P -190 REMARK 465 PHE P -189 REMARK 465 GLY P -188 REMARK 465 SER P -187 REMARK 465 SER P -186 REMARK 465 ASN P -185 REMARK 465 SER P -184 REMARK 465 PHE P -183 REMARK 465 PHE P -182 REMARK 465 ARG P -181 REMARK 465 ASN P -180 REMARK 465 MET P -179 REMARK 465 VAL P -178 REMARK 465 TRP P -177 REMARK 465 LEU P -176 REMARK 465 ILE P -175 REMARK 465 HIS P -174 REMARK 465 GLN P -173 REMARK 465 SER P -172 REMARK 465 GLY P -171 REMARK 465 THR P -170 REMARK 465 TYR P -169 REMARK 465 PRO P -168 REMARK 465 VAL P -167 REMARK 465 ILE P -166 REMARK 465 LYS P -165 REMARK 465 ARG P -164 REMARK 465 THR P -163 REMARK 465 PHE P -162 REMARK 465 ASN P -161 REMARK 465 ASN P -160 REMARK 465 THR P -159 REMARK 465 LYS P -158 REMARK 465 GLY P -157 REMARK 465 ARG P -156 REMARK 465 ASP P -155 REMARK 465 VAL P -154 REMARK 465 LEU P -153 REMARK 465 ILE P -152 REMARK 465 VAL P -151 REMARK 465 TRP P -150 REMARK 465 GLY P -149 REMARK 465 ILE P -148 REMARK 465 HIS P -147 REMARK 465 HIS P -146 REMARK 465 PRO P -145 REMARK 465 ALA P -144 REMARK 465 THR P -143 REMARK 465 LEU P -142 REMARK 465 LYS P -141 REMARK 465 GLU P -140 REMARK 465 HIS P -139 REMARK 465 GLN P -138 REMARK 465 ASP P -137 REMARK 465 LEU P -136 REMARK 465 TYR P -135 REMARK 465 LYS P -134 REMARK 465 LYS P -133 REMARK 465 ASP P -132 REMARK 465 SER P -131 REMARK 465 SER P -130 REMARK 465 TYR P -129 REMARK 465 VAL P -128 REMARK 465 ALA P -127 REMARK 465 VAL P -126 REMARK 465 GLY P -125 REMARK 465 SER P -124 REMARK 465 GLU P -123 REMARK 465 THR P -122 REMARK 465 TYR P -121 REMARK 465 ASN P -120 REMARK 465 ARG P -119 REMARK 465 ARG P -118 REMARK 465 PHE P -117 REMARK 465 THR P -116 REMARK 465 PRO P -115 REMARK 465 GLU P -114 REMARK 465 ILE P -113 REMARK 465 SER P -112 REMARK 465 THR P -111 REMARK 465 ARG P -110 REMARK 465 PRO P -109 REMARK 465 ASN P -108 REMARK 465 VAL P -107 REMARK 465 ASN P -106 REMARK 465 GLY P -105 REMARK 465 GLN P -104 REMARK 465 ALA P -103 REMARK 465 GLY P -102 REMARK 465 ARG P -101 REMARK 465 MET P -100 REMARK 465 THR P -99 REMARK 465 PHE P -98 REMARK 465 TYR P -97 REMARK 465 TRP P -96 REMARK 465 THR P -95 REMARK 465 MET P -94 REMARK 465 VAL P -93 REMARK 465 LYS P -92 REMARK 465 PRO P -91 REMARK 465 GLY P -90 REMARK 465 GLU P -89 REMARK 465 SER P -88 REMARK 465 ILE P -87 REMARK 465 THR P -86 REMARK 465 PHE P -85 REMARK 465 GLU P -84 REMARK 465 SER P -83 REMARK 465 ASN P -82 REMARK 465 GLY P -81 REMARK 465 ALA P -80 REMARK 465 PHE P -79 REMARK 465 LEU P -78 REMARK 465 ALA P -77 REMARK 465 PRO P -76 REMARK 465 ARG P -75 REMARK 465 TYR P -74 REMARK 465 ALA P -73 REMARK 465 PHE P -72 REMARK 465 GLU P -71 REMARK 465 ILE P -70 REMARK 465 VAL P -69 REMARK 465 SER P -68 REMARK 465 VAL P -67 REMARK 465 GLY P -66 REMARK 465 ASN P -65 REMARK 465 GLY P -64 REMARK 465 LYS P -63 REMARK 465 LEU P -62 REMARK 465 PHE P -61 REMARK 465 ARG P -60 REMARK 465 SER P -59 REMARK 465 GLU P -58 REMARK 465 LEU P -57 REMARK 465 SER P -56 REMARK 465 ILE P -55 REMARK 465 GLU P -54 REMARK 465 SER P -53 REMARK 465 CYS P -52 REMARK 465 ASN P -51 REMARK 465 THR P -50 REMARK 465 THR P -49 REMARK 465 CYS P -48 REMARK 465 GLN P -47 REMARK 465 THR P -46 REMARK 465 PRO P -45 REMARK 465 LYS P -44 REMARK 465 GLY P -43 REMARK 465 ALA P -42 REMARK 465 ILE P -41 REMARK 465 ASN P -40 REMARK 465 THR P -39 REMARK 465 SER P -38 REMARK 465 LEU P -37 REMARK 465 PRO P -36 REMARK 465 PHE P -35 REMARK 465 GLN P -34 REMARK 465 ASN P -33 REMARK 465 ILE P -32 REMARK 465 HIS P -31 REMARK 465 PRO P -30 REMARK 465 ILE P -29 REMARK 465 THR P -28 REMARK 465 ILE P -27 REMARK 465 GLY P -26 REMARK 465 LYS P -25 REMARK 465 CYS P -24 REMARK 465 PRO P -23 REMARK 465 LYS P -22 REMARK 465 TYR P -21 REMARK 465 VAL P -20 REMARK 465 LYS P -19 REMARK 465 SER P -18 REMARK 465 THR P -17 REMARK 465 LYS P -16 REMARK 465 LEU P -15 REMARK 465 ARG P -14 REMARK 465 LEU P -13 REMARK 465 ALA P -12 REMARK 465 THR P -11 REMARK 465 GLY P -10 REMARK 465 LEU P -9 REMARK 465 ARG P -8 REMARK 465 ASN P -7 REMARK 465 VAL P -6 REMARK 465 PRO P -5 REMARK 465 SER P -4 REMARK 465 ILE P -3 REMARK 465 GLN P -2 REMARK 465 SER P -1 REMARK 465 ARG P 0 REMARK 465 GLY P 1 REMARK 465 LEU P 2 REMARK 465 PHE P 3 REMARK 465 GLY P 4 REMARK 465 ALA P 5 REMARK 465 ILE P 6 REMARK 465 SER P 175 REMARK 465 GLY P 176 REMARK 465 ARG P 177 REMARK 465 ILE Q 333 REMARK 465 GLN Q 334 REMARK 465 SER Q 335 REMARK 465 ARG Q 336 REMARK 465 GLY Q 337 REMARK 465 LEU Q 338 REMARK 465 PHE Q 339 REMARK 465 GLY Q 340 REMARK 465 ALA Q 341 REMARK 465 ILE Q 342 REMARK 465 ALA Q 343 REMARK 465 GLY Q 344 REMARK 465 PHE Q 345 REMARK 465 ILE Q 346 REMARK 465 GLU Q 347 REMARK 465 GLY Q 348 REMARK 465 GLY Q 349 REMARK 465 TRP Q 350 REMARK 465 THR Q 351 REMARK 465 GLY Q 352 REMARK 465 MET Q 353 REMARK 465 VAL Q 354 REMARK 465 ASP Q 355 REMARK 465 GLY Q 356 REMARK 465 TRP Q 357 REMARK 465 TYR Q 358 REMARK 465 GLY Q 359 REMARK 465 TYR Q 360 REMARK 465 HIS Q 361 REMARK 465 HIS Q 362 REMARK 465 GLN Q 363 REMARK 465 ASN Q 364 REMARK 465 GLU Q 365 REMARK 465 GLN Q 366 REMARK 465 GLY Q 367 REMARK 465 SER Q 368 REMARK 465 GLY Q 369 REMARK 465 TYR Q 370 REMARK 465 ALA Q 371 REMARK 465 ALA Q 372 REMARK 465 ASP Q 373 REMARK 465 LEU Q 374 REMARK 465 LYS Q 375 REMARK 465 SER Q 376 REMARK 465 THR Q 377 REMARK 465 GLN Q 378 REMARK 465 ASN Q 379 REMARK 465 ALA Q 380 REMARK 465 ILE Q 381 REMARK 465 ASP Q 382 REMARK 465 GLY Q 383 REMARK 465 ILE Q 384 REMARK 465 THR Q 385 REMARK 465 ASN Q 386 REMARK 465 LYS Q 387 REMARK 465 VAL Q 388 REMARK 465 ASN Q 389 REMARK 465 SER Q 390 REMARK 465 VAL Q 391 REMARK 465 ILE Q 392 REMARK 465 GLU Q 393 REMARK 465 LYS Q 394 REMARK 465 MET Q 395 REMARK 465 ASN Q 396 REMARK 465 THR Q 397 REMARK 465 GLN Q 398 REMARK 465 PHE Q 399 REMARK 465 THR Q 400 REMARK 465 ALA Q 401 REMARK 465 VAL Q 402 REMARK 465 GLY Q 403 REMARK 465 LYS Q 404 REMARK 465 GLU Q 405 REMARK 465 PHE Q 406 REMARK 465 ASN Q 407 REMARK 465 HIS Q 408 REMARK 465 LEU Q 409 REMARK 465 GLU Q 410 REMARK 465 LYS Q 411 REMARK 465 ARG Q 412 REMARK 465 ILE Q 413 REMARK 465 GLU Q 414 REMARK 465 ASN Q 415 REMARK 465 LEU Q 416 REMARK 465 ASN Q 417 REMARK 465 LYS Q 418 REMARK 465 LYS Q 419 REMARK 465 VAL Q 420 REMARK 465 ASP Q 421 REMARK 465 ASP Q 422 REMARK 465 GLY Q 423 REMARK 465 PHE Q 424 REMARK 465 LEU Q 425 REMARK 465 ASP Q 426 REMARK 465 ILE Q 427 REMARK 465 TRP Q 428 REMARK 465 THR Q 429 REMARK 465 TYR Q 430 REMARK 465 ASN Q 431 REMARK 465 ALA Q 432 REMARK 465 GLU Q 433 REMARK 465 LEU Q 434 REMARK 465 LEU Q 435 REMARK 465 VAL Q 436 REMARK 465 LEU Q 437 REMARK 465 LEU Q 438 REMARK 465 GLU Q 439 REMARK 465 ASN Q 440 REMARK 465 GLU Q 441 REMARK 465 ARG Q 442 REMARK 465 THR Q 443 REMARK 465 LEU Q 444 REMARK 465 ASP Q 445 REMARK 465 TYR Q 446 REMARK 465 HIS Q 447 REMARK 465 ASP Q 448 REMARK 465 SER Q 449 REMARK 465 ASN Q 450 REMARK 465 VAL Q 451 REMARK 465 LYS Q 452 REMARK 465 ASN Q 453 REMARK 465 LEU Q 454 REMARK 465 TYR Q 455 REMARK 465 GLU Q 456 REMARK 465 LYS Q 457 REMARK 465 VAL Q 458 REMARK 465 ARG Q 459 REMARK 465 SER Q 460 REMARK 465 GLN Q 461 REMARK 465 LEU Q 462 REMARK 465 LYS Q 463 REMARK 465 ASN Q 464 REMARK 465 ASN Q 465 REMARK 465 ALA Q 466 REMARK 465 LYS Q 467 REMARK 465 GLU Q 468 REMARK 465 ILE Q 469 REMARK 465 GLY Q 470 REMARK 465 ASN Q 471 REMARK 465 GLY Q 472 REMARK 465 CYS Q 473 REMARK 465 PHE Q 474 REMARK 465 GLU Q 475 REMARK 465 PHE Q 476 REMARK 465 TYR Q 477 REMARK 465 HIS Q 478 REMARK 465 LYS Q 479 REMARK 465 CYS Q 480 REMARK 465 ASP Q 481 REMARK 465 ASN Q 482 REMARK 465 THR Q 483 REMARK 465 CYS Q 484 REMARK 465 MET Q 485 REMARK 465 GLU Q 486 REMARK 465 SER Q 487 REMARK 465 VAL Q 488 REMARK 465 LYS Q 489 REMARK 465 ASN Q 490 REMARK 465 GLY Q 491 REMARK 465 THR Q 492 REMARK 465 TYR Q 493 REMARK 465 ASP Q 494 REMARK 465 TYR Q 495 REMARK 465 PRO Q 496 REMARK 465 LYS Q 497 REMARK 465 TYR Q 498 REMARK 465 SER Q 499 REMARK 465 GLU Q 500 REMARK 465 GLU Q 501 REMARK 465 ALA Q 502 REMARK 465 LYS Q 503 REMARK 465 LEU Q 504 REMARK 465 ASN Q 505 REMARK 465 ARG Q 506 REMARK 465 GLU Q 507 REMARK 465 GLU Q 508 REMARK 465 ILE Q 509 REMARK 465 ASP Q 510 REMARK 465 SER Q 511 REMARK 465 GLY Q 512 REMARK 465 ARG Q 513 REMARK 465 GLU R 213 REMARK 465 CYS R 214 REMARK 465 LYS S 222 REMARK 465 SER S 223 REMARK 465 CYS S 224 REMARK 465 GLY U -326 REMARK 465 ASP U -325 REMARK 465 THR U -324 REMARK 465 LEU U -323 REMARK 465 CYS U -322 REMARK 465 ILE U -321 REMARK 465 GLY U -320 REMARK 465 TYR U -319 REMARK 465 HIS U -318 REMARK 465 ALA U -317 REMARK 465 ASN U -316 REMARK 465 ASN U -315 REMARK 465 SER U -314 REMARK 465 THR U -313 REMARK 465 ASP U -312 REMARK 465 THR U -311 REMARK 465 VAL U -310 REMARK 465 ASP U -309 REMARK 465 THR U -308 REMARK 465 LEU U -307 REMARK 465 LEU U -306 REMARK 465 GLU U -305 REMARK 465 LYS U -304 REMARK 465 ASN U -303 REMARK 465 VAL U -302 REMARK 465 THR U -301 REMARK 465 VAL U -300 REMARK 465 THR U -299 REMARK 465 HIS U -298 REMARK 465 SER U -297 REMARK 465 VAL U -296 REMARK 465 ASN U -295 REMARK 465 LEU U -294 REMARK 465 LEU U -293 REMARK 465 GLU U -292 REMARK 465 ASP U -291 REMARK 465 LYS U -290 REMARK 465 HIS U -289 REMARK 465 ASN U -288 REMARK 465 GLY U -287 REMARK 465 LYS U -286 REMARK 465 LEU U -285 REMARK 465 CYS U -284 REMARK 465 SER U -283 REMARK 465 ILE U -282 REMARK 465 ASN U -281 REMARK 465 GLY U -280 REMARK 465 LYS U -279 REMARK 465 GLN U -278 REMARK 465 PRO U -277 REMARK 465 ILE U -276 REMARK 465 SER U -275 REMARK 465 LEU U -274 REMARK 465 GLY U -273 REMARK 465 ASP U -272 REMARK 465 CYS U -271 REMARK 465 SER U -270 REMARK 465 PHE U -269 REMARK 465 ALA U -268 REMARK 465 GLY U -267 REMARK 465 TRP U -266 REMARK 465 ILE U -265 REMARK 465 LEU U -264 REMARK 465 GLY U -263 REMARK 465 ASN U -262 REMARK 465 PRO U -261 REMARK 465 MET U -260 REMARK 465 CYS U -259 REMARK 465 ASP U -258 REMARK 465 ASP U -257 REMARK 465 LEU U -256 REMARK 465 ILE U -255 REMARK 465 GLY U -254 REMARK 465 LYS U -253 REMARK 465 THR U -252 REMARK 465 SER U -251 REMARK 465 TRP U -250 REMARK 465 SER U -249 REMARK 465 TYR U -248 REMARK 465 ILE U -247 REMARK 465 VAL U -246 REMARK 465 GLU U -245 REMARK 465 LYS U -244 REMARK 465 PRO U -243 REMARK 465 ASN U -242 REMARK 465 PRO U -241 REMARK 465 THR U -240 REMARK 465 ASN U -239 REMARK 465 GLY U -238 REMARK 465 ILE U -237 REMARK 465 CYS U -236 REMARK 465 TYR U -235 REMARK 465 PRO U -234 REMARK 465 GLY U -233 REMARK 465 THR U -232 REMARK 465 LEU U -231 REMARK 465 GLU U -230 REMARK 465 ASP U -229 REMARK 465 GLU U -228 REMARK 465 GLU U -227 REMARK 465 GLU U -226 REMARK 465 LEU U -225 REMARK 465 ARG U -224 REMARK 465 LEU U -223 REMARK 465 LYS U -222 REMARK 465 PHE U -221 REMARK 465 SER U -220 REMARK 465 GLY U -219 REMARK 465 VAL U -218 REMARK 465 LEU U -217 REMARK 465 GLU U -216 REMARK 465 PHE U -215 REMARK 465 SER U -214 REMARK 465 LYS U -213 REMARK 465 PHE U -212 REMARK 465 GLU U -211 REMARK 465 ALA U -210 REMARK 465 PHE U -209 REMARK 465 THR U -208 REMARK 465 SER U -207 REMARK 465 ASN U -206 REMARK 465 GLY U -205 REMARK 465 TRP U -204 REMARK 465 GLY U -203 REMARK 465 ALA U -202 REMARK 465 VAL U -201 REMARK 465 ASN U -200 REMARK 465 SER U -199 REMARK 465 GLY U -198 REMARK 465 ALA U -197 REMARK 465 GLY U -196 REMARK 465 VAL U -195 REMARK 465 THR U -194 REMARK 465 ALA U -193 REMARK 465 ALA U -192 REMARK 465 CYS U -191 REMARK 465 LYS U -190 REMARK 465 PHE U -189 REMARK 465 GLY U -188 REMARK 465 SER U -187 REMARK 465 SER U -186 REMARK 465 ASN U -185 REMARK 465 SER U -184 REMARK 465 PHE U -183 REMARK 465 PHE U -182 REMARK 465 ARG U -181 REMARK 465 ASN U -180 REMARK 465 MET U -179 REMARK 465 VAL U -178 REMARK 465 TRP U -177 REMARK 465 LEU U -176 REMARK 465 ILE U -175 REMARK 465 HIS U -174 REMARK 465 GLN U -173 REMARK 465 SER U -172 REMARK 465 GLY U -171 REMARK 465 THR U -170 REMARK 465 TYR U -169 REMARK 465 PRO U -168 REMARK 465 VAL U -167 REMARK 465 ILE U -166 REMARK 465 LYS U -165 REMARK 465 ARG U -164 REMARK 465 THR U -163 REMARK 465 PHE U -162 REMARK 465 ASN U -161 REMARK 465 ASN U -160 REMARK 465 THR U -159 REMARK 465 LYS U -158 REMARK 465 GLY U -157 REMARK 465 ARG U -156 REMARK 465 ASP U -155 REMARK 465 VAL U -154 REMARK 465 LEU U -153 REMARK 465 ILE U -152 REMARK 465 VAL U -151 REMARK 465 TRP U -150 REMARK 465 GLY U -149 REMARK 465 ILE U -148 REMARK 465 HIS U -147 REMARK 465 HIS U -146 REMARK 465 PRO U -145 REMARK 465 ALA U -144 REMARK 465 THR U -143 REMARK 465 LEU U -142 REMARK 465 LYS U -141 REMARK 465 GLU U -140 REMARK 465 HIS U -139 REMARK 465 GLN U -138 REMARK 465 ASP U -137 REMARK 465 LEU U -136 REMARK 465 TYR U -135 REMARK 465 LYS U -134 REMARK 465 LYS U -133 REMARK 465 ASP U -132 REMARK 465 SER U -131 REMARK 465 SER U -130 REMARK 465 TYR U -129 REMARK 465 VAL U -128 REMARK 465 ALA U -127 REMARK 465 VAL U -126 REMARK 465 GLY U -125 REMARK 465 SER U -124 REMARK 465 GLU U -123 REMARK 465 THR U -122 REMARK 465 TYR U -121 REMARK 465 ASN U -120 REMARK 465 ARG U -119 REMARK 465 ARG U -118 REMARK 465 PHE U -117 REMARK 465 THR U -116 REMARK 465 PRO U -115 REMARK 465 GLU U -114 REMARK 465 ILE U -113 REMARK 465 SER U -112 REMARK 465 THR U -111 REMARK 465 ARG U -110 REMARK 465 PRO U -109 REMARK 465 ASN U -108 REMARK 465 VAL U -107 REMARK 465 ASN U -106 REMARK 465 GLY U -105 REMARK 465 GLN U -104 REMARK 465 ALA U -103 REMARK 465 GLY U -102 REMARK 465 ARG U -101 REMARK 465 MET U -100 REMARK 465 THR U -99 REMARK 465 PHE U -98 REMARK 465 TYR U -97 REMARK 465 TRP U -96 REMARK 465 THR U -95 REMARK 465 MET U -94 REMARK 465 VAL U -93 REMARK 465 LYS U -92 REMARK 465 PRO U -91 REMARK 465 GLY U -90 REMARK 465 GLU U -89 REMARK 465 SER U -88 REMARK 465 ILE U -87 REMARK 465 THR U -86 REMARK 465 PHE U -85 REMARK 465 GLU U -84 REMARK 465 SER U -83 REMARK 465 ASN U -82 REMARK 465 GLY U -81 REMARK 465 ALA U -80 REMARK 465 PHE U -79 REMARK 465 LEU U -78 REMARK 465 ALA U -77 REMARK 465 PRO U -76 REMARK 465 ARG U -75 REMARK 465 TYR U -74 REMARK 465 ALA U -73 REMARK 465 PHE U -72 REMARK 465 GLU U -71 REMARK 465 ILE U -70 REMARK 465 VAL U -69 REMARK 465 SER U -68 REMARK 465 VAL U -67 REMARK 465 GLY U -66 REMARK 465 ASN U -65 REMARK 465 GLY U -64 REMARK 465 LYS U -63 REMARK 465 LEU U -62 REMARK 465 PHE U -61 REMARK 465 ARG U -60 REMARK 465 SER U -59 REMARK 465 GLU U -58 REMARK 465 LEU U -57 REMARK 465 SER U -56 REMARK 465 ILE U -55 REMARK 465 GLU U -54 REMARK 465 SER U -53 REMARK 465 CYS U -52 REMARK 465 ASN U -51 REMARK 465 THR U -50 REMARK 465 THR U -49 REMARK 465 CYS U -48 REMARK 465 GLN U -47 REMARK 465 THR U -46 REMARK 465 PRO U -45 REMARK 465 LYS U -44 REMARK 465 GLY U -43 REMARK 465 ALA U -42 REMARK 465 ILE U -41 REMARK 465 ASN U -40 REMARK 465 THR U -39 REMARK 465 SER U -38 REMARK 465 LEU U -37 REMARK 465 PRO U -36 REMARK 465 PHE U -35 REMARK 465 GLN U -34 REMARK 465 ASN U -33 REMARK 465 ILE U -32 REMARK 465 HIS U -31 REMARK 465 PRO U -30 REMARK 465 ILE U -29 REMARK 465 THR U -28 REMARK 465 ILE U -27 REMARK 465 GLY U -26 REMARK 465 LYS U -25 REMARK 465 CYS U -24 REMARK 465 PRO U -23 REMARK 465 LYS U -22 REMARK 465 TYR U -21 REMARK 465 VAL U -20 REMARK 465 LYS U -19 REMARK 465 SER U -18 REMARK 465 THR U -17 REMARK 465 LYS U -16 REMARK 465 LEU U -15 REMARK 465 ARG U -14 REMARK 465 LEU U -13 REMARK 465 ALA U -12 REMARK 465 THR U -11 REMARK 465 GLY U -10 REMARK 465 LEU U -9 REMARK 465 ARG U -8 REMARK 465 ASN U -7 REMARK 465 VAL U -6 REMARK 465 PRO U -5 REMARK 465 SER U -4 REMARK 465 ILE U -3 REMARK 465 GLN U -2 REMARK 465 SER U -1 REMARK 465 ARG U 0 REMARK 465 GLY U 1 REMARK 465 LEU U 2 REMARK 465 PHE U 3 REMARK 465 GLY U 4 REMARK 465 ALA U 5 REMARK 465 ILE U 6 REMARK 465 SER U 175 REMARK 465 GLY U 176 REMARK 465 ARG U 177 REMARK 465 ILE V 333 REMARK 465 GLN V 334 REMARK 465 SER V 335 REMARK 465 ARG V 336 REMARK 465 GLY V 337 REMARK 465 LEU V 338 REMARK 465 PHE V 339 REMARK 465 GLY V 340 REMARK 465 ALA V 341 REMARK 465 ILE V 342 REMARK 465 ALA V 343 REMARK 465 GLY V 344 REMARK 465 PHE V 345 REMARK 465 ILE V 346 REMARK 465 GLU V 347 REMARK 465 GLY V 348 REMARK 465 GLY V 349 REMARK 465 TRP V 350 REMARK 465 THR V 351 REMARK 465 GLY V 352 REMARK 465 MET V 353 REMARK 465 VAL V 354 REMARK 465 ASP V 355 REMARK 465 GLY V 356 REMARK 465 TRP V 357 REMARK 465 TYR V 358 REMARK 465 GLY V 359 REMARK 465 TYR V 360 REMARK 465 HIS V 361 REMARK 465 HIS V 362 REMARK 465 GLN V 363 REMARK 465 ASN V 364 REMARK 465 GLU V 365 REMARK 465 GLN V 366 REMARK 465 GLY V 367 REMARK 465 SER V 368 REMARK 465 GLY V 369 REMARK 465 TYR V 370 REMARK 465 ALA V 371 REMARK 465 ALA V 372 REMARK 465 ASP V 373 REMARK 465 LEU V 374 REMARK 465 LYS V 375 REMARK 465 SER V 376 REMARK 465 THR V 377 REMARK 465 GLN V 378 REMARK 465 ASN V 379 REMARK 465 ALA V 380 REMARK 465 ILE V 381 REMARK 465 ASP V 382 REMARK 465 GLY V 383 REMARK 465 ILE V 384 REMARK 465 THR V 385 REMARK 465 ASN V 386 REMARK 465 LYS V 387 REMARK 465 VAL V 388 REMARK 465 ASN V 389 REMARK 465 SER V 390 REMARK 465 VAL V 391 REMARK 465 ILE V 392 REMARK 465 GLU V 393 REMARK 465 LYS V 394 REMARK 465 MET V 395 REMARK 465 ASN V 396 REMARK 465 THR V 397 REMARK 465 GLN V 398 REMARK 465 PHE V 399 REMARK 465 THR V 400 REMARK 465 ALA V 401 REMARK 465 VAL V 402 REMARK 465 GLY V 403 REMARK 465 LYS V 404 REMARK 465 GLU V 405 REMARK 465 PHE V 406 REMARK 465 ASN V 407 REMARK 465 HIS V 408 REMARK 465 LEU V 409 REMARK 465 GLU V 410 REMARK 465 LYS V 411 REMARK 465 ARG V 412 REMARK 465 ILE V 413 REMARK 465 GLU V 414 REMARK 465 ASN V 415 REMARK 465 LEU V 416 REMARK 465 ASN V 417 REMARK 465 LYS V 418 REMARK 465 LYS V 419 REMARK 465 VAL V 420 REMARK 465 ASP V 421 REMARK 465 ASP V 422 REMARK 465 GLY V 423 REMARK 465 PHE V 424 REMARK 465 LEU V 425 REMARK 465 ASP V 426 REMARK 465 ILE V 427 REMARK 465 TRP V 428 REMARK 465 THR V 429 REMARK 465 TYR V 430 REMARK 465 ASN V 431 REMARK 465 ALA V 432 REMARK 465 GLU V 433 REMARK 465 LEU V 434 REMARK 465 LEU V 435 REMARK 465 VAL V 436 REMARK 465 LEU V 437 REMARK 465 LEU V 438 REMARK 465 GLU V 439 REMARK 465 ASN V 440 REMARK 465 GLU V 441 REMARK 465 ARG V 442 REMARK 465 THR V 443 REMARK 465 LEU V 444 REMARK 465 ASP V 445 REMARK 465 TYR V 446 REMARK 465 HIS V 447 REMARK 465 ASP V 448 REMARK 465 SER V 449 REMARK 465 ASN V 450 REMARK 465 VAL V 451 REMARK 465 LYS V 452 REMARK 465 ASN V 453 REMARK 465 LEU V 454 REMARK 465 TYR V 455 REMARK 465 GLU V 456 REMARK 465 LYS V 457 REMARK 465 VAL V 458 REMARK 465 ARG V 459 REMARK 465 SER V 460 REMARK 465 GLN V 461 REMARK 465 LEU V 462 REMARK 465 LYS V 463 REMARK 465 ASN V 464 REMARK 465 ASN V 465 REMARK 465 ALA V 466 REMARK 465 LYS V 467 REMARK 465 GLU V 468 REMARK 465 ILE V 469 REMARK 465 GLY V 470 REMARK 465 ASN V 471 REMARK 465 GLY V 472 REMARK 465 CYS V 473 REMARK 465 PHE V 474 REMARK 465 GLU V 475 REMARK 465 PHE V 476 REMARK 465 TYR V 477 REMARK 465 HIS V 478 REMARK 465 LYS V 479 REMARK 465 CYS V 480 REMARK 465 ASP V 481 REMARK 465 ASN V 482 REMARK 465 THR V 483 REMARK 465 CYS V 484 REMARK 465 MET V 485 REMARK 465 GLU V 486 REMARK 465 SER V 487 REMARK 465 VAL V 488 REMARK 465 LYS V 489 REMARK 465 ASN V 490 REMARK 465 GLY V 491 REMARK 465 THR V 492 REMARK 465 TYR V 493 REMARK 465 ASP V 494 REMARK 465 TYR V 495 REMARK 465 PRO V 496 REMARK 465 LYS V 497 REMARK 465 TYR V 498 REMARK 465 SER V 499 REMARK 465 GLU V 500 REMARK 465 GLU V 501 REMARK 465 ALA V 502 REMARK 465 LYS V 503 REMARK 465 LEU V 504 REMARK 465 ASN V 505 REMARK 465 ARG V 506 REMARK 465 GLU V 507 REMARK 465 GLU V 508 REMARK 465 ILE V 509 REMARK 465 ASP V 510 REMARK 465 SER V 511 REMARK 465 GLY V 512 REMARK 465 ARG V 513 REMARK 465 ASP W 185 REMARK 465 GLU W 213 REMARK 465 CYS W 214 REMARK 465 LYS X 222 REMARK 465 SER X 223 REMARK 465 CYS X 224 REMARK 465 ILE Y 333 REMARK 465 GLN Y 334 REMARK 465 SER Y 335 REMARK 465 ARG Y 336 REMARK 465 GLY Y 337 REMARK 465 LEU Y 338 REMARK 465 PHE Y 339 REMARK 465 GLY Y 340 REMARK 465 ALA Y 341 REMARK 465 ILE Y 342 REMARK 465 ALA Y 343 REMARK 465 GLY Y 344 REMARK 465 PHE Y 345 REMARK 465 ILE Y 346 REMARK 465 GLU Y 347 REMARK 465 GLY Y 348 REMARK 465 GLY Y 349 REMARK 465 TRP Y 350 REMARK 465 THR Y 351 REMARK 465 GLY Y 352 REMARK 465 MET Y 353 REMARK 465 VAL Y 354 REMARK 465 ASP Y 355 REMARK 465 GLY Y 356 REMARK 465 TRP Y 357 REMARK 465 TYR Y 358 REMARK 465 GLY Y 359 REMARK 465 TYR Y 360 REMARK 465 HIS Y 361 REMARK 465 HIS Y 362 REMARK 465 GLN Y 363 REMARK 465 ASN Y 364 REMARK 465 GLU Y 365 REMARK 465 GLN Y 366 REMARK 465 GLY Y 367 REMARK 465 SER Y 368 REMARK 465 GLY Y 369 REMARK 465 TYR Y 370 REMARK 465 ALA Y 371 REMARK 465 ALA Y 372 REMARK 465 ASP Y 373 REMARK 465 LEU Y 374 REMARK 465 LYS Y 375 REMARK 465 SER Y 376 REMARK 465 THR Y 377 REMARK 465 GLN Y 378 REMARK 465 ASN Y 379 REMARK 465 ALA Y 380 REMARK 465 ILE Y 381 REMARK 465 ASP Y 382 REMARK 465 GLY Y 383 REMARK 465 ILE Y 384 REMARK 465 THR Y 385 REMARK 465 ASN Y 386 REMARK 465 LYS Y 387 REMARK 465 VAL Y 388 REMARK 465 ASN Y 389 REMARK 465 SER Y 390 REMARK 465 VAL Y 391 REMARK 465 ILE Y 392 REMARK 465 GLU Y 393 REMARK 465 LYS Y 394 REMARK 465 MET Y 395 REMARK 465 ASN Y 396 REMARK 465 THR Y 397 REMARK 465 GLN Y 398 REMARK 465 PHE Y 399 REMARK 465 THR Y 400 REMARK 465 ALA Y 401 REMARK 465 VAL Y 402 REMARK 465 GLY Y 403 REMARK 465 LYS Y 404 REMARK 465 GLU Y 405 REMARK 465 PHE Y 406 REMARK 465 ASN Y 407 REMARK 465 HIS Y 408 REMARK 465 LEU Y 409 REMARK 465 GLU Y 410 REMARK 465 LYS Y 411 REMARK 465 ARG Y 412 REMARK 465 ILE Y 413 REMARK 465 GLU Y 414 REMARK 465 ASN Y 415 REMARK 465 LEU Y 416 REMARK 465 ASN Y 417 REMARK 465 LYS Y 418 REMARK 465 LYS Y 419 REMARK 465 VAL Y 420 REMARK 465 ASP Y 421 REMARK 465 ASP Y 422 REMARK 465 GLY Y 423 REMARK 465 PHE Y 424 REMARK 465 LEU Y 425 REMARK 465 ASP Y 426 REMARK 465 ILE Y 427 REMARK 465 TRP Y 428 REMARK 465 THR Y 429 REMARK 465 TYR Y 430 REMARK 465 ASN Y 431 REMARK 465 ALA Y 432 REMARK 465 GLU Y 433 REMARK 465 LEU Y 434 REMARK 465 LEU Y 435 REMARK 465 VAL Y 436 REMARK 465 LEU Y 437 REMARK 465 LEU Y 438 REMARK 465 GLU Y 439 REMARK 465 ASN Y 440 REMARK 465 GLU Y 441 REMARK 465 ARG Y 442 REMARK 465 THR Y 443 REMARK 465 LEU Y 444 REMARK 465 ASP Y 445 REMARK 465 TYR Y 446 REMARK 465 HIS Y 447 REMARK 465 ASP Y 448 REMARK 465 SER Y 449 REMARK 465 ASN Y 450 REMARK 465 VAL Y 451 REMARK 465 LYS Y 452 REMARK 465 ASN Y 453 REMARK 465 LEU Y 454 REMARK 465 TYR Y 455 REMARK 465 GLU Y 456 REMARK 465 LYS Y 457 REMARK 465 VAL Y 458 REMARK 465 ARG Y 459 REMARK 465 SER Y 460 REMARK 465 GLN Y 461 REMARK 465 LEU Y 462 REMARK 465 LYS Y 463 REMARK 465 ASN Y 464 REMARK 465 ASN Y 465 REMARK 465 ALA Y 466 REMARK 465 LYS Y 467 REMARK 465 GLU Y 468 REMARK 465 ILE Y 469 REMARK 465 GLY Y 470 REMARK 465 ASN Y 471 REMARK 465 GLY Y 472 REMARK 465 CYS Y 473 REMARK 465 PHE Y 474 REMARK 465 GLU Y 475 REMARK 465 PHE Y 476 REMARK 465 TYR Y 477 REMARK 465 HIS Y 478 REMARK 465 LYS Y 479 REMARK 465 CYS Y 480 REMARK 465 ASP Y 481 REMARK 465 ASN Y 482 REMARK 465 THR Y 483 REMARK 465 CYS Y 484 REMARK 465 MET Y 485 REMARK 465 GLU Y 486 REMARK 465 SER Y 487 REMARK 465 VAL Y 488 REMARK 465 LYS Y 489 REMARK 465 ASN Y 490 REMARK 465 GLY Y 491 REMARK 465 THR Y 492 REMARK 465 TYR Y 493 REMARK 465 ASP Y 494 REMARK 465 TYR Y 495 REMARK 465 PRO Y 496 REMARK 465 LYS Y 497 REMARK 465 TYR Y 498 REMARK 465 SER Y 499 REMARK 465 GLU Y 500 REMARK 465 GLU Y 501 REMARK 465 ALA Y 502 REMARK 465 LYS Y 503 REMARK 465 LEU Y 504 REMARK 465 ASN Y 505 REMARK 465 ARG Y 506 REMARK 465 GLU Y 507 REMARK 465 GLU Y 508 REMARK 465 ILE Y 509 REMARK 465 ASP Y 510 REMARK 465 SER Y 511 REMARK 465 GLY Y 512 REMARK 465 ARG Y 513 REMARK 465 GLY a -326 REMARK 465 ASP a -325 REMARK 465 THR a -324 REMARK 465 LEU a -323 REMARK 465 CYS a -322 REMARK 465 ILE a -321 REMARK 465 GLY a -320 REMARK 465 TYR a -319 REMARK 465 HIS a -318 REMARK 465 ALA a -317 REMARK 465 ASN a -316 REMARK 465 ASN a -315 REMARK 465 SER a -314 REMARK 465 THR a -313 REMARK 465 ASP a -312 REMARK 465 THR a -311 REMARK 465 VAL a -310 REMARK 465 ASP a -309 REMARK 465 THR a -308 REMARK 465 LEU a -307 REMARK 465 LEU a -306 REMARK 465 GLU a -305 REMARK 465 LYS a -304 REMARK 465 ASN a -303 REMARK 465 VAL a -302 REMARK 465 THR a -301 REMARK 465 VAL a -300 REMARK 465 THR a -299 REMARK 465 HIS a -298 REMARK 465 SER a -297 REMARK 465 VAL a -296 REMARK 465 ASN a -295 REMARK 465 LEU a -294 REMARK 465 LEU a -293 REMARK 465 GLU a -292 REMARK 465 ASP a -291 REMARK 465 LYS a -290 REMARK 465 HIS a -289 REMARK 465 ASN a -288 REMARK 465 GLY a -287 REMARK 465 LYS a -286 REMARK 465 LEU a -285 REMARK 465 CYS a -284 REMARK 465 SER a -283 REMARK 465 ILE a -282 REMARK 465 ASN a -281 REMARK 465 GLY a -280 REMARK 465 LYS a -279 REMARK 465 GLN a -278 REMARK 465 PRO a -277 REMARK 465 ILE a -276 REMARK 465 SER a -275 REMARK 465 LEU a -274 REMARK 465 GLY a -273 REMARK 465 ASP a -272 REMARK 465 CYS a -271 REMARK 465 SER a -270 REMARK 465 PHE a -269 REMARK 465 ALA a -268 REMARK 465 GLY a -267 REMARK 465 TRP a -266 REMARK 465 ILE a -265 REMARK 465 LEU a -264 REMARK 465 GLY a -263 REMARK 465 ASN a -262 REMARK 465 PRO a -261 REMARK 465 MET a -260 REMARK 465 CYS a -259 REMARK 465 ASP a -258 REMARK 465 ASP a -257 REMARK 465 LEU a -256 REMARK 465 ILE a -255 REMARK 465 GLY a -254 REMARK 465 LYS a -253 REMARK 465 THR a -252 REMARK 465 SER a -251 REMARK 465 TRP a -250 REMARK 465 SER a -249 REMARK 465 TYR a -248 REMARK 465 ILE a -247 REMARK 465 VAL a -246 REMARK 465 GLU a -245 REMARK 465 LYS a -244 REMARK 465 PRO a -243 REMARK 465 ASN a -242 REMARK 465 PRO a -241 REMARK 465 THR a -240 REMARK 465 ASN a -239 REMARK 465 GLY a -238 REMARK 465 ILE a -237 REMARK 465 CYS a -236 REMARK 465 TYR a -235 REMARK 465 PRO a -234 REMARK 465 GLY a -233 REMARK 465 THR a -232 REMARK 465 LEU a -231 REMARK 465 GLU a -230 REMARK 465 ASP a -229 REMARK 465 GLU a -228 REMARK 465 GLU a -227 REMARK 465 GLU a -226 REMARK 465 LEU a -225 REMARK 465 ARG a -224 REMARK 465 LEU a -223 REMARK 465 LYS a -222 REMARK 465 PHE a -221 REMARK 465 SER a -220 REMARK 465 GLY a -219 REMARK 465 VAL a -218 REMARK 465 LEU a -217 REMARK 465 GLU a -216 REMARK 465 PHE a -215 REMARK 465 SER a -214 REMARK 465 LYS a -213 REMARK 465 PHE a -212 REMARK 465 GLU a -211 REMARK 465 ALA a -210 REMARK 465 PHE a -209 REMARK 465 THR a -208 REMARK 465 SER a -207 REMARK 465 ASN a -206 REMARK 465 GLY a -205 REMARK 465 TRP a -204 REMARK 465 GLY a -203 REMARK 465 ALA a -202 REMARK 465 VAL a -201 REMARK 465 ASN a -200 REMARK 465 SER a -199 REMARK 465 GLY a -198 REMARK 465 ALA a -197 REMARK 465 GLY a -196 REMARK 465 VAL a -195 REMARK 465 THR a -194 REMARK 465 ALA a -193 REMARK 465 ALA a -192 REMARK 465 CYS a -191 REMARK 465 LYS a -190 REMARK 465 PHE a -189 REMARK 465 GLY a -188 REMARK 465 SER a -187 REMARK 465 SER a -186 REMARK 465 ASN a -185 REMARK 465 SER a -184 REMARK 465 PHE a -183 REMARK 465 PHE a -182 REMARK 465 ARG a -181 REMARK 465 ASN a -180 REMARK 465 MET a -179 REMARK 465 VAL a -178 REMARK 465 TRP a -177 REMARK 465 LEU a -176 REMARK 465 ILE a -175 REMARK 465 HIS a -174 REMARK 465 GLN a -173 REMARK 465 SER a -172 REMARK 465 GLY a -171 REMARK 465 THR a -170 REMARK 465 TYR a -169 REMARK 465 PRO a -168 REMARK 465 VAL a -167 REMARK 465 ILE a -166 REMARK 465 LYS a -165 REMARK 465 ARG a -164 REMARK 465 THR a -163 REMARK 465 PHE a -162 REMARK 465 ASN a -161 REMARK 465 ASN a -160 REMARK 465 THR a -159 REMARK 465 LYS a -158 REMARK 465 GLY a -157 REMARK 465 ARG a -156 REMARK 465 ASP a -155 REMARK 465 VAL a -154 REMARK 465 LEU a -153 REMARK 465 ILE a -152 REMARK 465 VAL a -151 REMARK 465 TRP a -150 REMARK 465 GLY a -149 REMARK 465 ILE a -148 REMARK 465 HIS a -147 REMARK 465 HIS a -146 REMARK 465 PRO a -145 REMARK 465 ALA a -144 REMARK 465 THR a -143 REMARK 465 LEU a -142 REMARK 465 LYS a -141 REMARK 465 GLU a -140 REMARK 465 HIS a -139 REMARK 465 GLN a -138 REMARK 465 ASP a -137 REMARK 465 LEU a -136 REMARK 465 TYR a -135 REMARK 465 LYS a -134 REMARK 465 LYS a -133 REMARK 465 ASP a -132 REMARK 465 SER a -131 REMARK 465 SER a -130 REMARK 465 TYR a -129 REMARK 465 VAL a -128 REMARK 465 ALA a -127 REMARK 465 VAL a -126 REMARK 465 GLY a -125 REMARK 465 SER a -124 REMARK 465 GLU a -123 REMARK 465 THR a -122 REMARK 465 TYR a -121 REMARK 465 ASN a -120 REMARK 465 ARG a -119 REMARK 465 ARG a -118 REMARK 465 PHE a -117 REMARK 465 THR a -116 REMARK 465 PRO a -115 REMARK 465 GLU a -114 REMARK 465 ILE a -113 REMARK 465 SER a -112 REMARK 465 THR a -111 REMARK 465 ARG a -110 REMARK 465 PRO a -109 REMARK 465 ASN a -108 REMARK 465 VAL a -107 REMARK 465 ASN a -106 REMARK 465 GLY a -105 REMARK 465 GLN a -104 REMARK 465 ALA a -103 REMARK 465 GLY a -102 REMARK 465 ARG a -101 REMARK 465 MET a -100 REMARK 465 THR a -99 REMARK 465 PHE a -98 REMARK 465 TYR a -97 REMARK 465 TRP a -96 REMARK 465 THR a -95 REMARK 465 MET a -94 REMARK 465 VAL a -93 REMARK 465 LYS a -92 REMARK 465 PRO a -91 REMARK 465 GLY a -90 REMARK 465 GLU a -89 REMARK 465 SER a -88 REMARK 465 ILE a -87 REMARK 465 THR a -86 REMARK 465 PHE a -85 REMARK 465 GLU a -84 REMARK 465 SER a -83 REMARK 465 ASN a -82 REMARK 465 GLY a -81 REMARK 465 ALA a -80 REMARK 465 PHE a -79 REMARK 465 LEU a -78 REMARK 465 ALA a -77 REMARK 465 PRO a -76 REMARK 465 ARG a -75 REMARK 465 TYR a -74 REMARK 465 ALA a -73 REMARK 465 PHE a -72 REMARK 465 GLU a -71 REMARK 465 ILE a -70 REMARK 465 VAL a -69 REMARK 465 SER a -68 REMARK 465 VAL a -67 REMARK 465 GLY a -66 REMARK 465 ASN a -65 REMARK 465 GLY a -64 REMARK 465 LYS a -63 REMARK 465 LEU a -62 REMARK 465 PHE a -61 REMARK 465 ARG a -60 REMARK 465 SER a -59 REMARK 465 GLU a -58 REMARK 465 LEU a -57 REMARK 465 SER a -56 REMARK 465 ILE a -55 REMARK 465 GLU a -54 REMARK 465 SER a -53 REMARK 465 CYS a -52 REMARK 465 ASN a -51 REMARK 465 THR a -50 REMARK 465 THR a -49 REMARK 465 CYS a -48 REMARK 465 GLN a -47 REMARK 465 THR a -46 REMARK 465 PRO a -45 REMARK 465 LYS a -44 REMARK 465 GLY a -43 REMARK 465 ALA a -42 REMARK 465 ILE a -41 REMARK 465 ASN a -40 REMARK 465 THR a -39 REMARK 465 SER a -38 REMARK 465 LEU a -37 REMARK 465 PRO a -36 REMARK 465 PHE a -35 REMARK 465 GLN a -34 REMARK 465 ASN a -33 REMARK 465 ILE a -32 REMARK 465 HIS a -31 REMARK 465 PRO a -30 REMARK 465 ILE a -29 REMARK 465 THR a -28 REMARK 465 ILE a -27 REMARK 465 GLY a -26 REMARK 465 LYS a -25 REMARK 465 CYS a -24 REMARK 465 PRO a -23 REMARK 465 LYS a -22 REMARK 465 TYR a -21 REMARK 465 VAL a -20 REMARK 465 LYS a -19 REMARK 465 SER a -18 REMARK 465 THR a -17 REMARK 465 LYS a -16 REMARK 465 LEU a -15 REMARK 465 ARG a -14 REMARK 465 LEU a -13 REMARK 465 ALA a -12 REMARK 465 THR a -11 REMARK 465 GLY a -10 REMARK 465 LEU a -9 REMARK 465 ARG a -8 REMARK 465 ASN a -7 REMARK 465 VAL a -6 REMARK 465 PRO a -5 REMARK 465 SER a -4 REMARK 465 ILE a -3 REMARK 465 GLN a -2 REMARK 465 SER a -1 REMARK 465 ARG a 0 REMARK 465 GLY a 1 REMARK 465 LEU a 2 REMARK 465 PHE a 3 REMARK 465 GLY a 4 REMARK 465 ALA a 5 REMARK 465 ILE a 6 REMARK 465 SER a 175 REMARK 465 GLY a 176 REMARK 465 ARG a 177 REMARK 465 ILE b 334 REMARK 465 GLN b 335 REMARK 465 SER b 336 REMARK 465 ARG b 337 REMARK 465 GLY b 338 REMARK 465 LEU b 339 REMARK 465 PHE b 340 REMARK 465 GLY b 341 REMARK 465 ALA b 342 REMARK 465 ILE b 343 REMARK 465 ALA b 344 REMARK 465 GLY b 345 REMARK 465 PHE b 346 REMARK 465 ILE b 347 REMARK 465 GLU b 348 REMARK 465 GLY b 349 REMARK 465 GLY b 350 REMARK 465 TRP b 351 REMARK 465 THR b 352 REMARK 465 GLY b 353 REMARK 465 MET b 354 REMARK 465 VAL b 355 REMARK 465 ASP b 356 REMARK 465 GLY b 357 REMARK 465 TRP b 358 REMARK 465 TYR b 359 REMARK 465 GLY b 360 REMARK 465 TYR b 361 REMARK 465 HIS b 362 REMARK 465 HIS b 363 REMARK 465 GLN b 364 REMARK 465 ASN b 365 REMARK 465 GLU b 366 REMARK 465 GLN b 367 REMARK 465 GLY b 368 REMARK 465 SER b 369 REMARK 465 GLY b 370 REMARK 465 TYR b 371 REMARK 465 ALA b 372 REMARK 465 ALA b 373 REMARK 465 ASP b 374 REMARK 465 LEU b 375 REMARK 465 LYS b 376 REMARK 465 SER b 377 REMARK 465 THR b 378 REMARK 465 GLN b 379 REMARK 465 ASN b 380 REMARK 465 ALA b 381 REMARK 465 ILE b 382 REMARK 465 ASP b 383 REMARK 465 GLY b 384 REMARK 465 ILE b 385 REMARK 465 THR b 386 REMARK 465 ASN b 387 REMARK 465 LYS b 388 REMARK 465 VAL b 389 REMARK 465 ASN b 390 REMARK 465 SER b 391 REMARK 465 VAL b 392 REMARK 465 ILE b 393 REMARK 465 GLU b 394 REMARK 465 LYS b 395 REMARK 465 MET b 396 REMARK 465 ASN b 397 REMARK 465 THR b 398 REMARK 465 GLN b 399 REMARK 465 PHE b 400 REMARK 465 THR b 401 REMARK 465 ALA b 402 REMARK 465 VAL b 403 REMARK 465 GLY b 404 REMARK 465 LYS b 405 REMARK 465 GLU b 406 REMARK 465 PHE b 407 REMARK 465 ASN b 408 REMARK 465 HIS b 409 REMARK 465 LEU b 410 REMARK 465 GLU b 411 REMARK 465 LYS b 412 REMARK 465 ARG b 413 REMARK 465 ILE b 414 REMARK 465 GLU b 415 REMARK 465 ASN b 416 REMARK 465 LEU b 417 REMARK 465 ASN b 418 REMARK 465 LYS b 419 REMARK 465 LYS b 420 REMARK 465 VAL b 421 REMARK 465 ASP b 422 REMARK 465 ASP b 423 REMARK 465 GLY b 424 REMARK 465 PHE b 425 REMARK 465 LEU b 426 REMARK 465 ASP b 427 REMARK 465 ILE b 428 REMARK 465 TRP b 429 REMARK 465 THR b 430 REMARK 465 TYR b 431 REMARK 465 ASN b 432 REMARK 465 ALA b 433 REMARK 465 GLU b 434 REMARK 465 LEU b 435 REMARK 465 LEU b 436 REMARK 465 VAL b 437 REMARK 465 LEU b 438 REMARK 465 LEU b 439 REMARK 465 GLU b 440 REMARK 465 ASN b 441 REMARK 465 GLU b 442 REMARK 465 ARG b 443 REMARK 465 THR b 444 REMARK 465 LEU b 445 REMARK 465 ASP b 446 REMARK 465 TYR b 447 REMARK 465 HIS b 448 REMARK 465 ASP b 449 REMARK 465 SER b 450 REMARK 465 ASN b 451 REMARK 465 VAL b 452 REMARK 465 LYS b 453 REMARK 465 ASN b 454 REMARK 465 LEU b 455 REMARK 465 TYR b 456 REMARK 465 GLU b 457 REMARK 465 LYS b 458 REMARK 465 VAL b 459 REMARK 465 ARG b 460 REMARK 465 SER b 461 REMARK 465 GLN b 462 REMARK 465 LEU b 463 REMARK 465 LYS b 464 REMARK 465 ASN b 465 REMARK 465 ASN b 466 REMARK 465 ALA b 467 REMARK 465 LYS b 468 REMARK 465 GLU b 469 REMARK 465 ILE b 470 REMARK 465 GLY b 471 REMARK 465 ASN b 472 REMARK 465 GLY b 473 REMARK 465 CYS b 474 REMARK 465 PHE b 475 REMARK 465 GLU b 476 REMARK 465 PHE b 477 REMARK 465 TYR b 478 REMARK 465 HIS b 479 REMARK 465 LYS b 480 REMARK 465 CYS b 481 REMARK 465 ASP b 482 REMARK 465 ASN b 483 REMARK 465 THR b 484 REMARK 465 CYS b 485 REMARK 465 MET b 486 REMARK 465 GLU b 487 REMARK 465 SER b 488 REMARK 465 VAL b 489 REMARK 465 LYS b 490 REMARK 465 ASN b 491 REMARK 465 GLY b 492 REMARK 465 THR b 493 REMARK 465 TYR b 494 REMARK 465 ASP b 495 REMARK 465 TYR b 496 REMARK 465 PRO b 497 REMARK 465 LYS b 498 REMARK 465 TYR b 499 REMARK 465 SER b 500 REMARK 465 GLU b 501 REMARK 465 GLU b 502 REMARK 465 ALA b 503 REMARK 465 LYS b 504 REMARK 465 LEU b 505 REMARK 465 ASN b 506 REMARK 465 ARG b 507 REMARK 465 GLU b 508 REMARK 465 GLU b 509 REMARK 465 ILE b 510 REMARK 465 ASP b 511 REMARK 465 SER b 512 REMARK 465 GLY b 513 REMARK 465 ARG b 514 REMARK 465 GLU c 213 REMARK 465 CYS c 214 REMARK 465 LYS d 222 REMARK 465 SER d 223 REMARK 465 CYS d 224 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 O VAL L 210 NH1 ARG L 218 1.08 REMARK 500 C VAL L 210 NH1 ARG L 218 1.68 REMARK 500 OE1 GLN E 39 O LYS E 43 1.95 REMARK 500 O SER Q 116 O GLY Q 272 2.06 REMARK 500 OG SER E 7 OG1 THR E 21 2.07 REMARK 500 ND2 ASN Y 175 O3 NAG O 1 2.10 REMARK 500 OG SER C 53 OG SER C 87 2.11 REMARK 500 O LEU V 113 OG SER V 116 2.11 REMARK 500 OG SER N 7 OG1 THR N 21 2.13 REMARK 500 OG SER d 7 OG1 THR d 21 2.13 REMARK 500 O SER d 140 OG1 THR d 143 2.15 REMARK 500 OG1 THR K 102 O GLY K 105 2.16 REMARK 500 OG SER K 7 OG1 THR K 21 2.16 REMARK 500 OG SER W 162 OG SER W 176 2.17 REMARK 500 NZ LYS V 57 OE2 GLU V 120A 2.18 REMARK 500 CG2 ILE b 54 O CYS b 285 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500 REMARK 500 DISTANCE CUTOFF: REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 CA THR S 199 OG SER c 182 3654 1.70 REMARK 500 C THR S 199 OG SER c 182 3654 1.70 REMARK 500 CD GLN M 3 OG SER d 84 3554 2.13 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 PRO Q 59 CD PRO Q 59 N 0.134 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 GLU C 125 CB - CA - C ANGL. DEV. = -14.7 DEGREES REMARK 500 ALA C 126 N - CA - CB ANGL. DEV. = -12.1 DEGREES REMARK 500 GLY E 44 N - CA - C ANGL. DEV. = 15.0 DEGREES REMARK 500 GLN H 62 N - CA - CB ANGL. DEV. = -12.3 DEGREES REMARK 500 GLN H 62 N - CA - C ANGL. DEV. = 17.7 DEGREES REMARK 500 ALA J 51 CB - CA - C ANGL. DEV. = 10.9 DEGREES REMARK 500 SER J 52 N - CA - CB ANGL. DEV. = -10.2 DEGREES REMARK 500 LYS J 190 N - CA - CB ANGL. DEV. = -12.0 DEGREES REMARK 500 LYS J 190 N - CA - C ANGL. DEV. = 16.8 DEGREES REMARK 500 ALA L 139 N - CA - C ANGL. DEV. = -30.9 DEGREES REMARK 500 ALA L 294 CB - CA - C ANGL. DEV. = 9.7 DEGREES REMARK 500 CYS M 134 CA - CB - SG ANGL. DEV. = 6.9 DEGREES REMARK 500 PHE N 154 N - CA - C ANGL. DEV. = 18.4 DEGREES REMARK 500 PRO N 155 N - CA - C ANGL. DEV. = -19.8 DEGREES REMARK 500 ASN Q 20 CB - CA - C ANGL. DEV. = -12.3 DEGREES REMARK 500 ILE Q 54 CB - CA - C ANGL. DEV. = -15.1 DEGREES REMARK 500 ILE Q 54 N - CA - C ANGL. DEV. = 32.2 DEGREES REMARK 500 ASN Q 55 N - CA - C ANGL. DEV. = -21.9 DEGREES REMARK 500 PRO Q 59 N - CA - CB ANGL. DEV. = 7.5 DEGREES REMARK 500 PRO Q 59 N - CA - C ANGL. DEV. = -17.0 DEGREES REMARK 500 LYS Q 92 N - CA - CB ANGL. DEV. = -11.1 DEGREES REMARK 500 GLY Q 272 N - CA - C ANGL. DEV. = -18.1 DEGREES REMARK 500 THR Q 287 N - CA - CB ANGL. DEV. = -12.7 DEGREES REMARK 500 THR Q 287 N - CA - C ANGL. DEV. = 16.7 DEGREES REMARK 500 SER S 19 N - CA - CB ANGL. DEV. = -9.6 DEGREES REMARK 500 ALA W 34 N - CA - CB ANGL. DEV. = -10.9 DEGREES REMARK 500 ALA X 87 N - CA - CB ANGL. DEV. = 11.2 DEGREES REMARK 500 HIS Y 47 CB - CA - C ANGL. DEV. = 12.3 DEGREES REMARK 500 HIS Y 47 N - CA - C ANGL. DEV. = -17.2 DEGREES REMARK 500 SER a 163 CB - CA - C ANGL. DEV. = -12.6 DEGREES REMARK 500 LEU b 62 CB - CA - C ANGL. DEV. = 21.4 DEGREES REMARK 500 LEU b 62 N - CA - C ANGL. DEV. = -36.3 DEGREES REMARK 500 LYS b 114 N - CA - C ANGL. DEV. = -16.9 DEGREES REMARK 500 SER b 122 N - CA - CB ANGL. DEV. = -14.8 DEGREES REMARK 500 GLY b 141 N - CA - C ANGL. DEV. = -24.8 DEGREES REMARK 500 VAL b 142 N - CA - C ANGL. DEV. = -19.7 DEGREES REMARK 500 CYS b 285 CB - CA - C ANGL. DEV. = 13.3 DEGREES REMARK 500 ALA c 51 CB - CA - C ANGL. DEV. = 10.0 DEGREES REMARK 500 CYS c 194 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLU B 11 -53.41 -127.65 REMARK 500 GLU B 74 36.90 -142.31 REMARK 500 ASN B 135 31.05 -93.44 REMARK 500 ASN C 20 -156.56 -149.66 REMARK 500 ASP C 64 33.53 -96.78 REMARK 500 LEU C 80 75.32 -118.76 REMARK 500 SER C 87 -44.55 -133.83 REMARK 500 LEU C 119 65.91 -153.32 REMARK 500 PHE C 121 73.99 -118.25 REMARK 500 ALA C 126 -91.08 -122.36 REMARK 500 CYS C 145 46.26 -92.53 REMARK 500 SER C 152 -167.98 -162.37 REMARK 500 SER C 212 -159.93 -139.18 REMARK 500 ASN C 216 96.67 -163.71 REMARK 500 SER C 224 146.30 -176.46 REMARK 500 ARG C 261 -50.76 -122.49 REMARK 500 LYS C 273 -166.80 -104.42 REMARK 500 GLU C 278 67.49 -106.74 REMARK 500 GLU C 282 -78.38 -133.15 REMARK 500 SER D 30 -123.90 53.74 REMARK 500 TRP D 32 62.93 -101.01 REMARK 500 LYS D 50 17.15 49.98 REMARK 500 ALA D 51 -50.45 70.39 REMARK 500 ALA D 84 -164.79 -170.24 REMARK 500 SER D 182 -76.11 -96.88 REMARK 500 ALA D 184 2.20 -68.63 REMARK 500 LYS D 188 -78.49 -107.53 REMARK 500 LYS D 190 -155.91 -120.25 REMARK 500 PRO E 14 6.93 -68.26 REMARK 500 SER E 15 39.36 -143.68 REMARK 500 ALA E 41 -129.46 53.67 REMARK 500 LYS E 43 -164.79 -111.49 REMARK 500 SER E 54 50.95 -102.99 REMARK 500 ARG E 64 -69.09 -105.55 REMARK 500 HIS E 100 -169.38 -77.42 REMARK 500 SER E 140 39.45 -94.12 REMARK 500 ASP E 152 63.19 60.43 REMARK 500 TYR E 202 74.07 -150.37 REMARK 500 THR H 61 -157.99 -139.30 REMARK 500 GLU H 74 35.42 -143.45 REMARK 500 LEU H 126 70.75 -104.00 REMARK 500 PHE I 9 -6.82 -142.11 REMARK 500 ALA I 35 118.89 -160.13 REMARK 500 ASN I 135 48.97 -101.77 REMARK 500 HIS I 142 -162.26 -115.99 REMARK 500 SER J 30 -121.14 60.22 REMARK 500 LYS J 50 9.29 58.85 REMARK 500 ALA J 51 -11.00 65.59 REMARK 500 SER J 52 19.03 -145.48 REMARK 500 ALA J 84 -174.07 -171.36 REMARK 500 REMARK 500 THIS ENTRY HAS 195 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 PHE C 115 SER C 116 146.94 REMARK 500 GLN W 27 SER W 28 -147.74 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG E 38 0.11 SIDE CHAIN REMARK 500 ARG I 76 0.13 SIDE CHAIN REMARK 500 ARG V 218 0.11 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY REMARK 500 REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME; REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 500 I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI ANGLE REMARK 500 CYS Q 52 -11.18 REMARK 500 PHE b 121 11.12 REMARK 500 REMARK 500 REMARK: NULL REMARK 610 REMARK 610 MISSING HETEROATOM REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 610 I=INSERTION CODE): REMARK 610 M RES C SSEQI REMARK 610 NAG A 1 REMARK 610 NAG F 1 REMARK 610 NAG G 1 REMARK 610 NAG O 1 REMARK 610 NAG T 1 REMARK 610 NAG Z 1 REMARK 610 NAG e 1 REMARK 610 NAG V 601 DBREF 9C22 B -326 177 PDB 9C22 9C22 -326 177 DBREF 9C22 C 10 513 PDB 9C22 9C22 10 513 DBREF 9C22 D 1 214 PDB 9C22 9C22 1 214 DBREF 9C22 E 1 224 PDB 9C22 9C22 1 224 DBREF 9C22 H -326 177 PDB 9C22 9C22 -326 177 DBREF 9C22 I -326 177 PDB 9C22 9C22 -326 177 DBREF 9C22 J 1 214 PDB 9C22 9C22 1 214 DBREF 9C22 K 1 224 PDB 9C22 9C22 1 224 DBREF 9C22 L 10 513 PDB 9C22 9C22 10 513 DBREF 9C22 M 1 214 PDB 9C22 9C22 1 214 DBREF 9C22 N 1 224 PDB 9C22 9C22 1 224 DBREF 9C22 P -326 177 PDB 9C22 9C22 -326 177 DBREF 9C22 Q 10 513 PDB 9C22 9C22 10 513 DBREF 9C22 R 1 214 PDB 9C22 9C22 1 214 DBREF 9C22 S 1 224 PDB 9C22 9C22 1 224 DBREF 9C22 U -326 177 PDB 9C22 9C22 -326 177 DBREF 9C22 V 10 513 PDB 9C22 9C22 10 513 DBREF 9C22 W 1 214 PDB 9C22 9C22 1 214 DBREF 9C22 X 1 224 PDB 9C22 9C22 1 224 DBREF 9C22 Y 10 513 PDB 9C22 9C22 10 513 DBREF 9C22 a -326 177 PDB 9C22 9C22 -326 177 DBREF 9C22 b 10 514 PDB 9C22 9C22 10 514 DBREF 9C22 c 1 214 PDB 9C22 9C22 1 214 DBREF 9C22 d 1 224 PDB 9C22 9C22 1 224 SEQRES 1 B 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 B 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 B 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 B 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 B 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 B 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 B 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 B 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 B 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 B 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 B 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 B 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 B 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 B 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 B 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 B 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 B 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 B 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 B 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 B 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 B 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 B 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 B 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 B 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 B 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 B 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 B 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 B 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 B 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 B 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 B 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 B 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 B 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 B 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 B 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 B 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 B 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 B 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 B 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 C 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 C 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 C 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 C 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 C 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 C 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 C 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 C 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 C 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 C 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 C 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 C 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 C 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 C 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 C 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 C 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 C 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 C 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 C 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 C 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 C 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 C 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 C 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 C 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 C 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 C 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 C 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 C 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 C 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 C 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 C 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 C 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 C 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 C 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 C 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 C 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 C 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 C 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 C 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 D 214 ASP ILE GLN MET THR GLN SER PRO ALA THR LEU SER ALA SEQRES 2 D 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 D 214 GLN SER ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 D 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR LYS ALA SER SEQRES 5 D 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 D 214 GLY SER GLY SER GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 D 214 GLN PRO ASP ASP PHE ALA ILE TYR TYR CYS GLN GLN TYR SEQRES 8 D 214 ASN SER TYR PRO TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 D 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 D 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 D 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 D 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 D 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 D 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 D 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 D 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 D 214 PHE ASN ARG GLY GLU CYS SEQRES 1 E 224 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 E 224 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 E 224 ALA SER ILE SER SER TYR TYR TRP ILE TRP ILE ARG GLN SEQRES 4 E 224 PRO ALA GLY LYS GLY LEU GLU TRP ILE GLY ARG PHE TYR SEQRES 5 E 224 THR SER GLY SER PRO ASN TYR ASN PRO SER LEU ARG SER SEQRES 6 E 224 ARG VAL THR MET SER VAL ASP THR SER LYS ASN GLN PHE SEQRES 7 E 224 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 E 224 VAL TYR TYR CYS ALA ARG GLU GLU HIS ILE THR PHE GLY SEQRES 9 E 224 GLY VAL ILE VAL ARG TYR TRP GLY GLN GLY THR LEU VAL SEQRES 10 E 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 E 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 E 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 E 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 E 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 E 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 E 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 E 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 E 224 LYS SER CYS SEQRES 1 H 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 H 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 H 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 H 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 H 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 H 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 H 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 H 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 H 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 H 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 H 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 H 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 H 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 H 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 H 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 H 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 H 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 H 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 H 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 H 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 H 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 H 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 H 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 H 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 H 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 H 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 H 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 H 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 H 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 H 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 H 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 H 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 H 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 H 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 H 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 H 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 H 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 H 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 H 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 I 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 I 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 I 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 I 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 I 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 I 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 I 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 I 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 I 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 I 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 I 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 I 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 I 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 I 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 I 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 I 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 I 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 I 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 I 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 I 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 I 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 I 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 I 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 I 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 I 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 I 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 I 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 I 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 I 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 I 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 I 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 I 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 I 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 I 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 I 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 I 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 I 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 I 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 I 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 J 214 ASP ILE GLN MET THR GLN SER PRO ALA THR LEU SER ALA SEQRES 2 J 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 J 214 GLN SER ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 J 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR LYS ALA SER SEQRES 5 J 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 J 214 GLY SER GLY SER GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 J 214 GLN PRO ASP ASP PHE ALA ILE TYR TYR CYS GLN GLN TYR SEQRES 8 J 214 ASN SER TYR PRO TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 J 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 J 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 J 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 J 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 J 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 J 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 J 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 J 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 J 214 PHE ASN ARG GLY GLU CYS SEQRES 1 K 224 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 K 224 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 K 224 ALA SER ILE SER SER TYR TYR TRP ILE TRP ILE ARG GLN SEQRES 4 K 224 PRO ALA GLY LYS GLY LEU GLU TRP ILE GLY ARG PHE TYR SEQRES 5 K 224 THR SER GLY SER PRO ASN TYR ASN PRO SER LEU ARG SER SEQRES 6 K 224 ARG VAL THR MET SER VAL ASP THR SER LYS ASN GLN PHE SEQRES 7 K 224 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 K 224 VAL TYR TYR CYS ALA ARG GLU GLU HIS ILE THR PHE GLY SEQRES 9 K 224 GLY VAL ILE VAL ARG TYR TRP GLY GLN GLY THR LEU VAL SEQRES 10 K 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 K 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 K 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 K 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 K 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 K 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 K 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 K 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 K 224 LYS SER CYS SEQRES 1 L 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 L 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 L 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 L 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 L 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 L 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 L 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 L 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 L 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 L 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 L 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 L 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 L 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 L 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 L 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 L 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 L 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 L 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 L 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 L 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 L 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 L 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 L 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 L 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 L 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 L 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 L 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 L 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 L 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 L 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 L 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 L 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 L 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 L 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 L 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 L 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 L 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 L 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 L 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 M 214 ASP ILE GLN MET THR GLN SER PRO ALA THR LEU SER ALA SEQRES 2 M 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 M 214 GLN SER ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 M 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR LYS ALA SER SEQRES 5 M 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 M 214 GLY SER GLY SER GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 M 214 GLN PRO ASP ASP PHE ALA ILE TYR TYR CYS GLN GLN TYR SEQRES 8 M 214 ASN SER TYR PRO TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 M 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 M 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 M 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 M 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 M 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 M 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 M 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 M 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 M 214 PHE ASN ARG GLY GLU CYS SEQRES 1 N 224 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 N 224 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 N 224 ALA SER ILE SER SER TYR TYR TRP ILE TRP ILE ARG GLN SEQRES 4 N 224 PRO ALA GLY LYS GLY LEU GLU TRP ILE GLY ARG PHE TYR SEQRES 5 N 224 THR SER GLY SER PRO ASN TYR ASN PRO SER LEU ARG SER SEQRES 6 N 224 ARG VAL THR MET SER VAL ASP THR SER LYS ASN GLN PHE SEQRES 7 N 224 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 N 224 VAL TYR TYR CYS ALA ARG GLU GLU HIS ILE THR PHE GLY SEQRES 9 N 224 GLY VAL ILE VAL ARG TYR TRP GLY GLN GLY THR LEU VAL SEQRES 10 N 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 N 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 N 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 N 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 N 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 N 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 N 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 N 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 N 224 LYS SER CYS SEQRES 1 P 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 P 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 P 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 P 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 P 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 P 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 P 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 P 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 P 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 P 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 P 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 P 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 P 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 P 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 P 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 P 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 P 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 P 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 P 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 P 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 P 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 P 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 P 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 P 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 P 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 P 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 P 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 P 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 P 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 P 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 P 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 P 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 P 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 P 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 P 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 P 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 P 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 P 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 P 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 Q 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 Q 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 Q 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 Q 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 Q 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 Q 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 Q 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 Q 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 Q 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 Q 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 Q 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 Q 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 Q 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 Q 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 Q 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 Q 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 Q 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 Q 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 Q 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 Q 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 Q 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 Q 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 Q 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 Q 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 Q 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 Q 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 Q 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 Q 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 Q 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 Q 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 Q 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 Q 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 Q 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 Q 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 Q 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 Q 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 Q 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 Q 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 Q 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 R 214 ASP ILE GLN MET THR GLN SER PRO ALA THR LEU SER ALA SEQRES 2 R 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 R 214 GLN SER ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 R 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR LYS ALA SER SEQRES 5 R 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 R 214 GLY SER GLY SER GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 R 214 GLN PRO ASP ASP PHE ALA ILE TYR TYR CYS GLN GLN TYR SEQRES 8 R 214 ASN SER TYR PRO TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 R 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 R 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 R 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 R 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 R 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 R 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 R 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 R 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 R 214 PHE ASN ARG GLY GLU CYS SEQRES 1 S 224 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 S 224 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 S 224 ALA SER ILE SER SER TYR TYR TRP ILE TRP ILE ARG GLN SEQRES 4 S 224 PRO ALA GLY LYS GLY LEU GLU TRP ILE GLY ARG PHE TYR SEQRES 5 S 224 THR SER GLY SER PRO ASN TYR ASN PRO SER LEU ARG SER SEQRES 6 S 224 ARG VAL THR MET SER VAL ASP THR SER LYS ASN GLN PHE SEQRES 7 S 224 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 S 224 VAL TYR TYR CYS ALA ARG GLU GLU HIS ILE THR PHE GLY SEQRES 9 S 224 GLY VAL ILE VAL ARG TYR TRP GLY GLN GLY THR LEU VAL SEQRES 10 S 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 S 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 S 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 S 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 S 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 S 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 S 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 S 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 S 224 LYS SER CYS SEQRES 1 U 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 U 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 U 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 U 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 U 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 U 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 U 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 U 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 U 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 U 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 U 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 U 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 U 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 U 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 U 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 U 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 U 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 U 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 U 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 U 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 U 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 U 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 U 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 U 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 U 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 U 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 U 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 U 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 U 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 U 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 U 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 U 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 U 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 U 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 U 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 U 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 U 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 U 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 U 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 V 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 V 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 V 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 V 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 V 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 V 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 V 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 V 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 V 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 V 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 V 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 V 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 V 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 V 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 V 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 V 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 V 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 V 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 V 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 V 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 V 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 V 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 V 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 V 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 V 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 V 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 V 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 V 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 V 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 V 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 V 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 V 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 V 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 V 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 V 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 V 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 V 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 V 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 V 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 W 214 ASP ILE GLN MET THR GLN SER PRO ALA THR LEU SER ALA SEQRES 2 W 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 W 214 GLN SER ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 W 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR LYS ALA SER SEQRES 5 W 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 W 214 GLY SER GLY SER GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 W 214 GLN PRO ASP ASP PHE ALA ILE TYR TYR CYS GLN GLN TYR SEQRES 8 W 214 ASN SER TYR PRO TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 W 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 W 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 W 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 W 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 W 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 W 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 W 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 W 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 W 214 PHE ASN ARG GLY GLU CYS SEQRES 1 X 224 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 X 224 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 X 224 ALA SER ILE SER SER TYR TYR TRP ILE TRP ILE ARG GLN SEQRES 4 X 224 PRO ALA GLY LYS GLY LEU GLU TRP ILE GLY ARG PHE TYR SEQRES 5 X 224 THR SER GLY SER PRO ASN TYR ASN PRO SER LEU ARG SER SEQRES 6 X 224 ARG VAL THR MET SER VAL ASP THR SER LYS ASN GLN PHE SEQRES 7 X 224 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 X 224 VAL TYR TYR CYS ALA ARG GLU GLU HIS ILE THR PHE GLY SEQRES 9 X 224 GLY VAL ILE VAL ARG TYR TRP GLY GLN GLY THR LEU VAL SEQRES 10 X 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 X 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 X 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 X 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 X 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 X 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 X 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 X 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 X 224 LYS SER CYS SEQRES 1 Y 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 Y 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 Y 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 Y 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 Y 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 Y 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 Y 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 Y 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 Y 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 Y 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 Y 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 Y 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 Y 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 Y 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 Y 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 Y 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 Y 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 Y 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 Y 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 Y 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 Y 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 Y 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 Y 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 Y 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 Y 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 Y 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 Y 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 Y 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 Y 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 Y 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 Y 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 Y 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 Y 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 Y 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 Y 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 Y 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 Y 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 Y 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 Y 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 a 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 a 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 a 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 a 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 a 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 a 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 a 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 a 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 a 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 a 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 a 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 a 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 a 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 a 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 a 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 a 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 a 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 a 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 a 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 a 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 a 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 a 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 a 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 a 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 a 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 a 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 a 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 a 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 a 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 a 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 a 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 a 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 a 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 a 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 a 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 a 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 a 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 a 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 a 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 b 504 GLY ASP THR LEU CYS ILE GLY TYR HIS ALA ASN ASN SER SEQRES 2 b 504 THR ASP THR VAL ASP THR LEU LEU GLU LYS ASN VAL THR SEQRES 3 b 504 VAL THR HIS SER VAL ASN LEU LEU GLU ASP LYS HIS ASN SEQRES 4 b 504 GLY LYS LEU CYS SER ILE ASN GLY LYS GLN PRO ILE SER SEQRES 5 b 504 LEU GLY ASP CYS SER PHE ALA GLY TRP ILE LEU GLY ASN SEQRES 6 b 504 PRO MET CYS ASP ASP LEU ILE GLY LYS THR SER TRP SER SEQRES 7 b 504 TYR ILE VAL GLU LYS PRO ASN PRO THR ASN GLY ILE CYS SEQRES 8 b 504 TYR PRO GLY THR LEU GLU ASP GLU GLU GLU LEU ARG LEU SEQRES 9 b 504 LYS PHE SER GLY VAL LEU GLU PHE SER LYS PHE GLU ALA SEQRES 10 b 504 PHE THR SER ASN GLY TRP GLY ALA VAL ASN SER GLY ALA SEQRES 11 b 504 GLY VAL THR ALA ALA CYS LYS PHE GLY SER SER ASN SER SEQRES 12 b 504 PHE PHE ARG ASN MET VAL TRP LEU ILE HIS GLN SER GLY SEQRES 13 b 504 THR TYR PRO VAL ILE LYS ARG THR PHE ASN ASN THR LYS SEQRES 14 b 504 GLY ARG ASP VAL LEU ILE VAL TRP GLY ILE HIS HIS PRO SEQRES 15 b 504 ALA THR LEU LYS GLU HIS GLN ASP LEU TYR LYS LYS ASP SEQRES 16 b 504 SER SER TYR VAL ALA VAL GLY SER GLU THR TYR ASN ARG SEQRES 17 b 504 ARG PHE THR PRO GLU ILE SER THR ARG PRO ASN VAL ASN SEQRES 18 b 504 GLY GLN ALA GLY ARG MET THR PHE TYR TRP THR MET VAL SEQRES 19 b 504 LYS PRO GLY GLU SER ILE THR PHE GLU SER ASN GLY ALA SEQRES 20 b 504 PHE LEU ALA PRO ARG TYR ALA PHE GLU ILE VAL SER VAL SEQRES 21 b 504 GLY ASN GLY LYS LEU PHE ARG SER GLU LEU SER ILE GLU SEQRES 22 b 504 SER CYS ASN THR THR CYS GLN THR PRO LYS GLY ALA ILE SEQRES 23 b 504 ASN THR SER LEU PRO PHE GLN ASN ILE HIS PRO ILE THR SEQRES 24 b 504 ILE GLY LYS CYS PRO LYS TYR VAL LYS SER THR LYS LEU SEQRES 25 b 504 ARG LEU ALA THR GLY LEU ARG ASN VAL PRO SER ILE GLN SEQRES 26 b 504 SER ARG GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU SEQRES 27 b 504 GLY GLY TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR SEQRES 28 b 504 HIS HIS GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP SEQRES 29 b 504 LEU LYS SER THR GLN ASN ALA ILE ASP GLY ILE THR ASN SEQRES 30 b 504 LYS VAL ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE SEQRES 31 b 504 THR ALA VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG SEQRES 32 b 504 ILE GLU ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU SEQRES 33 b 504 ASP ILE TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU SEQRES 34 b 504 GLU ASN GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL SEQRES 35 b 504 LYS ASN LEU TYR GLU LYS VAL ARG SER GLN LEU LYS ASN SEQRES 36 b 504 ASN ALA LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR SEQRES 37 b 504 HIS LYS CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN SEQRES 38 b 504 GLY THR TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS SEQRES 39 b 504 LEU ASN ARG GLU GLU ILE ASP SER GLY ARG SEQRES 1 c 214 ASP ILE GLN MET THR GLN SER PRO ALA THR LEU SER ALA SEQRES 2 c 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS ARG ALA SER SEQRES 3 c 214 GLN SER ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 c 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR LYS ALA SER SEQRES 5 c 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 c 214 GLY SER GLY SER GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 c 214 GLN PRO ASP ASP PHE ALA ILE TYR TYR CYS GLN GLN TYR SEQRES 8 c 214 ASN SER TYR PRO TRP THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 c 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 c 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 c 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 c 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 c 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 c 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 c 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 c 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 c 214 PHE ASN ARG GLY GLU CYS SEQRES 1 d 224 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 d 224 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 d 224 ALA SER ILE SER SER TYR TYR TRP ILE TRP ILE ARG GLN SEQRES 4 d 224 PRO ALA GLY LYS GLY LEU GLU TRP ILE GLY ARG PHE TYR SEQRES 5 d 224 THR SER GLY SER PRO ASN TYR ASN PRO SER LEU ARG SER SEQRES 6 d 224 ARG VAL THR MET SER VAL ASP THR SER LYS ASN GLN PHE SEQRES 7 d 224 SER LEU LYS LEU THR SER VAL THR ALA ALA ASP THR ALA SEQRES 8 d 224 VAL TYR TYR CYS ALA ARG GLU GLU HIS ILE THR PHE GLY SEQRES 9 d 224 GLY VAL ILE VAL ARG TYR TRP GLY GLN GLY THR LEU VAL SEQRES 10 d 224 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 d 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 d 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 d 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 d 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 d 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 d 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 d 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 d 224 LYS SER CYS HET NAG A 1 14 HET NAG A 2 14 HET NAG F 1 14 HET NAG F 2 14 HET BMA F 3 11 HET NAG G 1 14 HET NAG G 2 14 HET BMA G 3 11 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG Z 1 14 HET NAG Z 2 14 HET NAG e 1 14 HET NAG e 2 14 HET BMA e 3 11 HET NAG V 601 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 25 NAG 15(C8 H15 N O6) FORMUL 26 BMA 5(C6 H12 O6) HELIX 1 AA1 ASP B 37 MET B 59 1 23 HELIX 2 AA2 GLU B 74 LEU B 126 1 53 HELIX 3 AA3 ASP B 145 ASN B 154 1 10 HELIX 4 AA4 ASP B 158 ASP B 174 1 17 HELIX 5 AA5 SER C 66 GLY C 73 1 8 HELIX 6 AA6 ASP C 107 SER C 116 1 10 HELIX 7 AA7 THR C 193 LYS C 202 1 10 HELIX 8 AA8 GLN D 79 PHE D 83 5 5 HELIX 9 AA9 SER D 121 SER D 127 1 7 HELIX 10 AB1 ALA D 184 HIS D 189 1 6 HELIX 11 AB2 SER E 28 TYR E 32 5 5 HELIX 12 AB3 SER E 164 ALA E 166 5 3 HELIX 13 AB4 SER E 195 GLN E 200 5 6 HELIX 14 AB5 ASP H 37 ASN H 60 1 24 HELIX 15 AB6 ASN H 71 LEU H 73 5 3 HELIX 16 AB7 GLU H 74 LEU H 126 1 53 HELIX 17 AB8 ASP H 145 ASN H 154 1 10 HELIX 18 AB9 ASP H 158 ASP H 174 1 17 HELIX 19 AC1 ASP I 37 LYS I 58 1 22 HELIX 20 AC2 GLU I 74 LEU I 126 1 53 HELIX 21 AC3 ASP I 145 ASN I 154 1 10 HELIX 22 AC4 ASP I 158 ASP I 174 1 17 HELIX 23 AC5 GLN J 79 PHE J 83 5 5 HELIX 24 AC6 SER J 121 SER J 127 1 7 HELIX 25 AC7 SER K 28 TYR K 32 5 5 HELIX 26 AC8 ASN K 60 SER K 65 1 6 HELIX 27 AC9 THR K 86 THR K 90 5 5 HELIX 28 AD1 SER K 164 ALA K 166 5 3 HELIX 29 AD2 SER K 195 GLN K 200 1 6 HELIX 30 AD3 SER L 66 GLY L 73 1 8 HELIX 31 AD4 CYS L 77 ILE L 81 5 5 HELIX 32 AD5 ASP L 107 GLY L 117 1 11 HELIX 33 AD6 THR L 128 TRP L 132 5 5 HELIX 34 AD7 THR L 193 LYS L 202 1 10 HELIX 35 AD8 GLN M 79 PHE M 83 5 5 HELIX 36 AD9 SER M 121 SER M 127 1 7 HELIX 37 AE1 SER N 28 TYR N 32 5 5 HELIX 38 AE2 ASN N 60 SER N 65 1 6 HELIX 39 AE3 SER N 164 ALA N 166 5 3 HELIX 40 AE4 SER N 195 GLY N 198 5 4 HELIX 41 AE5 ASP P 37 LYS P 58 1 22 HELIX 42 AE6 GLU P 74 LYS P 127 1 54 HELIX 43 AE7 ASP P 145 ASN P 154 1 10 HELIX 44 AE8 ASP P 158 ASP P 174 1 17 HELIX 45 AE9 SER Q 66 GLY Q 73 1 8 HELIX 46 AF1 ASN Q 74 ASP Q 78 5 5 HELIX 47 AF2 ASP Q 107 GLY Q 117 1 11 HELIX 48 AF3 THR Q 193 LYS Q 202 1 10 HELIX 49 AF4 GLN R 79 PHE R 83 5 5 HELIX 50 AF5 SER R 121 SER R 127 1 7 HELIX 51 AF6 ASN S 60 SER S 65 1 6 HELIX 52 AF7 THR S 86 THR S 90 5 5 HELIX 53 AF8 SER S 164 ALA S 166 5 3 HELIX 54 AF9 SER S 195 GLN S 200 1 6 HELIX 55 AG1 ASP U 37 MET U 59 1 23 HELIX 56 AG2 GLU U 74 LYS U 127 1 54 HELIX 57 AG3 ASP U 145 ASN U 154 1 10 HELIX 58 AG4 ASP U 158 ASP U 174 1 17 HELIX 59 AG5 SER V 66 GLY V 73 1 8 HELIX 60 AG6 ASP V 107 GLY V 117 1 11 HELIX 61 AG7 THR V 193 LYS V 202 1 10 HELIX 62 AG8 GLN W 79 PHE W 83 5 5 HELIX 63 AG9 SER W 121 SER W 127 1 7 HELIX 64 AH1 SER X 28 TYR X 32 5 5 HELIX 65 AH2 ASN X 60 SER X 65 1 6 HELIX 66 AH3 SER X 164 ALA X 166 5 3 HELIX 67 AH4 SER X 195 GLY X 198 5 4 HELIX 68 AH5 SER Y 66 GLY Y 73 1 8 HELIX 69 AH6 CYS Y 77 ILE Y 81 5 5 HELIX 70 AH7 ASP Y 107 GLY Y 117 1 11 HELIX 71 AH8 THR Y 193 LYS Y 202 1 10 HELIX 72 AH9 ASP a 37 MET a 59 1 23 HELIX 73 AI1 GLU a 74 LEU a 126 1 53 HELIX 74 AI2 ASP a 145 ASN a 154 1 10 HELIX 75 AI3 TYR a 159 LYS a 161 5 3 HELIX 76 AI4 TYR a 162 GLU a 172 1 11 HELIX 77 AI5 ASN b 74 LEU b 80 5 7 HELIX 78 AI6 ASP b 107 LEU b 113 1 7 HELIX 79 AI7 THR b 194 LYS b 203 1 10 HELIX 80 AI8 GLN c 79 PHE c 83 5 5 HELIX 81 AI9 SER c 121 SER c 127 1 7 HELIX 82 AJ1 LYS c 183 GLU c 187 5 5 HELIX 83 AJ2 SER d 28 TYR d 32 5 5 HELIX 84 AJ3 ASN d 60 SER d 65 1 6 HELIX 85 AJ4 THR d 86 THR d 90 5 5 HELIX 86 AJ5 SER d 135 THR d 139 5 5 HELIX 87 AJ6 SER d 164 ALA d 166 5 3 HELIX 88 AJ7 SER d 195 GLN d 200 1 6 SHEET 1 AA1 5 GLY B 31 ALA B 36 0 SHEET 2 AA1 5 TYR B 22 ASN B 28 -1 N ASN B 28 O GLY B 31 SHEET 3 AA1 5 THR C 12 TYR C 17 -1 O THR C 12 N GLN B 27 SHEET 4 AA1 5 CYS B 137 PHE B 140 -1 N PHE B 138 O LEU C 13 SHEET 5 AA1 5 ALA B 130 ILE B 133 -1 N LYS B 131 O GLU B 139 SHEET 1 AA2 2 THR C 25 VAL C 26 0 SHEET 2 AA2 2 VAL C 34 THR C 35 -1 O VAL C 34 N VAL C 26 SHEET 1 AA3 2 SER C 39 ASN C 41 0 SHEET 2 AA3 2 ARG C 322 ALA C 324 -1 O LEU C 323 N VAL C 40 SHEET 1 AA4 3 LEU C 43 GLU C 44 0 SHEET 2 AA4 3 PHE C 301 GLN C 302 1 O PHE C 301 N GLU C 44 SHEET 3 AA4 3 LYS C 314 TYR C 315 1 O LYS C 314 N GLN C 302 SHEET 1 AA5 3 ILE C 60 SER C 61 0 SHEET 2 AA5 3 ILE C 89 GLU C 91 1 O VAL C 90 N ILE C 60 SHEET 3 AA5 3 LEU C 274 ARG C 276 1 O PHE C 275 N ILE C 89 SHEET 1 AA6 5 GLY C 103 LEU C 105 0 SHEET 2 AA6 5 ARG C 235 VAL C 243 1 O PHE C 238 N THR C 104 SHEET 3 AA6 5 VAL C 182 HIS C 190 -1 N ILE C 184 O THR C 241 SHEET 4 AA6 5 PHE C 257 PRO C 260 -1 O LEU C 258 N GLY C 187 SHEET 5 AA6 5 MET C 157 TRP C 159 -1 N VAL C 158 O ALA C 259 SHEET 1 AA7 4 GLY C 103 LEU C 105 0 SHEET 2 AA7 4 ARG C 235 VAL C 243 1 O PHE C 238 N THR C 104 SHEET 3 AA7 4 VAL C 182 HIS C 190 -1 N ILE C 184 O THR C 241 SHEET 4 AA7 4 PHE C 264 GLU C 265 -1 O PHE C 264 N LEU C 183 SHEET 1 AA8 2 VAL C 135 ASN C 136 0 SHEET 2 AA8 2 ILE C 161 HIS C 162 -1 O ILE C 161 N ASN C 136 SHEET 1 AA9 4 ILE C 170 ASN C 175 0 SHEET 2 AA9 4 SER C 248 SER C 253 -1 O PHE C 251 N ARG C 172 SHEET 3 AA9 4 VAL C 208 GLY C 211 -1 N GLY C 211 O THR C 250 SHEET 4 AA9 4 ASN C 216 PHE C 219 -1 O PHE C 219 N VAL C 208 SHEET 1 AB1 3 GLY C 293 ILE C 295 0 SHEET 2 AB1 3 CYS C 288 THR C 290 -1 N CYS C 288 O ILE C 295 SHEET 3 AB1 3 ILE C 309 GLY C 310 -1 O ILE C 309 N GLN C 289 SHEET 1 AB2 4 MET D 4 SER D 7 0 SHEET 2 AB2 4 VAL D 19 ALA D 25 -1 O ARG D 24 N THR D 5 SHEET 3 AB2 4 GLU D 70 ILE D 75 -1 O PHE D 71 N CYS D 23 SHEET 4 AB2 4 PHE D 62 SER D 65 -1 N SER D 63 O THR D 74 SHEET 1 AB3 6 THR D 10 SER D 12 0 SHEET 2 AB3 6 THR D 102 GLU D 105 1 O LYS D 103 N LEU D 11 SHEET 3 AB3 6 ALA D 84 GLN D 90 -1 N TYR D 86 O THR D 102 SHEET 4 AB3 6 LEU D 33 GLN D 38 -1 N GLN D 38 O ILE D 85 SHEET 5 AB3 6 PRO D 44 TYR D 49 -1 O LEU D 47 N TRP D 35 SHEET 6 AB3 6 SER D 53 LEU D 54 -1 O SER D 53 N TYR D 49 SHEET 1 AB4 4 SER D 114 PHE D 118 0 SHEET 2 AB4 4 ALA D 130 PHE D 139 -1 O VAL D 133 N PHE D 118 SHEET 3 AB4 4 TYR D 173 LEU D 181 -1 O LEU D 179 N VAL D 132 SHEET 4 AB4 4 SER D 159 THR D 164 -1 N GLN D 160 O THR D 178 SHEET 1 AB5 4 ALA D 153 LEU D 154 0 SHEET 2 AB5 4 ALA D 144 VAL D 150 -1 N VAL D 150 O ALA D 153 SHEET 3 AB5 4 TYR D 192 HIS D 198 -1 O THR D 197 N LYS D 145 SHEET 4 AB5 4 VAL D 205 PHE D 209 -1 O VAL D 205 N VAL D 196 SHEET 1 AB6 4 GLN E 3 SER E 7 0 SHEET 2 AB6 4 LEU E 18 SER E 25 -1 O SER E 25 N GLN E 3 SHEET 3 AB6 4 GLN E 77 LEU E 82 -1 O PHE E 78 N CYS E 22 SHEET 4 AB6 4 VAL E 67 ASP E 72 -1 N ASP E 72 O GLN E 77 SHEET 1 AB7 6 LEU E 11 VAL E 12 0 SHEET 2 AB7 6 THR E 115 VAL E 119 1 O THR E 118 N VAL E 12 SHEET 3 AB7 6 ALA E 91 GLU E 98 -1 N ALA E 91 O VAL E 117 SHEET 4 AB7 6 TYR E 33 GLN E 39 -1 N ILE E 37 O TYR E 94 SHEET 5 AB7 6 GLU E 46 PHE E 51 -1 O PHE E 51 N TRP E 34 SHEET 6 AB7 6 ASN E 58 TYR E 59 -1 O ASN E 58 N ARG E 50 SHEET 1 AB8 2 ILE E 101 THR E 102 0 SHEET 2 AB8 2 GLY E 105 VAL E 106 -1 O GLY E 105 N THR E 102 SHEET 1 AB9 4 SER E 128 LEU E 132 0 SHEET 2 AB9 4 ALA E 144 TYR E 153 -1 O GLY E 147 N LEU E 132 SHEET 3 AB9 4 TYR E 184 VAL E 192 -1 O LEU E 186 N VAL E 150 SHEET 4 AB9 4 VAL E 177 LEU E 178 -1 N VAL E 177 O SER E 185 SHEET 1 AC1 3 VAL E 158 TRP E 162 0 SHEET 2 AC1 3 ILE E 203 HIS E 208 -1 O ASN E 205 N SER E 161 SHEET 3 AC1 3 THR E 213 ARG E 218 -1 O VAL E 215 N VAL E 206 SHEET 1 AC2 5 GLY H 31 ALA H 36 0 SHEET 2 AC2 5 TYR H 22 ASN H 28 -1 N TYR H 24 O ALA H 35 SHEET 3 AC2 5 THR L 12 TYR L 17 -1 O CYS L 14 N HIS H 25 SHEET 4 AC2 5 CYS H 137 PHE H 140 -1 N PHE H 138 O LEU L 13 SHEET 5 AC2 5 ALA H 130 GLU H 132 -1 N LYS H 131 O GLU H 139 SHEET 1 AC3 5 GLY I 31 ALA I 36 0 SHEET 2 AC3 5 TYR I 22 ASN I 28 -1 N TYR I 24 O ALA I 35 SHEET 3 AC3 5 THR Y 12 TYR Y 17 -1 O THR Y 12 N GLN I 27 SHEET 4 AC3 5 CYS I 137 PHE I 140 -1 N PHE I 138 O LEU Y 13 SHEET 5 AC3 5 ALA I 130 ILE I 133 -1 N LYS I 131 O GLU I 139 SHEET 1 AC4 4 MET J 4 SER J 7 0 SHEET 2 AC4 4 VAL J 19 ALA J 25 -1 O ARG J 24 N THR J 5 SHEET 3 AC4 4 GLU J 70 ILE J 75 -1 O PHE J 71 N CYS J 23 SHEET 4 AC4 4 PHE J 62 SER J 67 -1 N SER J 63 O THR J 74 SHEET 1 AC5 6 THR J 10 SER J 12 0 SHEET 2 AC5 6 THR J 102 GLU J 105 1 O GLU J 105 N LEU J 11 SHEET 3 AC5 6 ALA J 84 GLN J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AC5 6 LEU J 33 GLN J 38 -1 N GLN J 38 O ILE J 85 SHEET 5 AC5 6 PRO J 44 TYR J 49 -1 O LEU J 47 N TRP J 35 SHEET 6 AC5 6 SER J 53 LEU J 54 -1 O SER J 53 N TYR J 49 SHEET 1 AC6 4 THR J 10 SER J 12 0 SHEET 2 AC6 4 THR J 102 GLU J 105 1 O GLU J 105 N LEU J 11 SHEET 3 AC6 4 ALA J 84 GLN J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AC6 4 THR J 97 PHE J 98 -1 O THR J 97 N GLN J 90 SHEET 1 AC7 4 SER J 114 PHE J 118 0 SHEET 2 AC7 4 VAL J 132 PHE J 139 -1 O VAL J 133 N PHE J 118 SHEET 3 AC7 4 TYR J 173 LEU J 179 -1 O LEU J 179 N VAL J 132 SHEET 4 AC7 4 SER J 159 VAL J 163 -1 N SER J 162 O SER J 176 SHEET 1 AC8 4 ALA J 153 LEU J 154 0 SHEET 2 AC8 4 ALA J 144 VAL J 150 -1 N VAL J 150 O ALA J 153 SHEET 3 AC8 4 VAL J 191 HIS J 198 -1 O GLU J 195 N GLN J 147 SHEET 4 AC8 4 VAL J 205 ASN J 210 -1 O VAL J 205 N VAL J 196 SHEET 1 AC9 4 GLN K 3 SER K 7 0 SHEET 2 AC9 4 LEU K 18 SER K 25 -1 O SER K 25 N GLN K 3 SHEET 3 AC9 4 GLN K 77 LEU K 82 -1 O PHE K 78 N CYS K 22 SHEET 4 AC9 4 VAL K 67 ASP K 72 -1 N ASP K 72 O GLN K 77 SHEET 1 AD1 5 ASN K 58 TYR K 59 0 SHEET 2 AD1 5 GLU K 46 PHE K 51 -1 N ARG K 50 O ASN K 58 SHEET 3 AD1 5 TYR K 33 GLN K 39 -1 N ARG K 38 O GLU K 46 SHEET 4 AD1 5 ALA K 91 GLU K 98 -1 O VAL K 92 N GLN K 39 SHEET 5 AD1 5 THR K 115 VAL K 117 -1 O THR K 115 N TYR K 93 SHEET 1 AD2 4 SER K 128 LEU K 132 0 SHEET 2 AD2 4 THR K 143 LYS K 151 -1 O GLY K 147 N LEU K 132 SHEET 3 AD2 4 TYR K 184 PRO K 193 -1 O LEU K 186 N VAL K 150 SHEET 4 AD2 4 VAL K 171 THR K 173 -1 N HIS K 172 O VAL K 189 SHEET 1 AD3 4 SER K 128 LEU K 132 0 SHEET 2 AD3 4 THR K 143 LYS K 151 -1 O GLY K 147 N LEU K 132 SHEET 3 AD3 4 TYR K 184 PRO K 193 -1 O LEU K 186 N VAL K 150 SHEET 4 AD3 4 VAL K 177 LEU K 178 -1 N VAL K 177 O SER K 185 SHEET 1 AD4 3 VAL K 160 TRP K 162 0 SHEET 2 AD4 3 TYR K 202 HIS K 208 -1 O ASN K 205 N SER K 161 SHEET 3 AD4 3 THR K 213 VAL K 219 -1 O VAL K 215 N VAL K 206 SHEET 1 AD5 2 THR L 25 VAL L 26 0 SHEET 2 AD5 2 VAL L 34 THR L 35 -1 O VAL L 34 N VAL L 26 SHEET 1 AD6 2 SER L 39 VAL L 40 0 SHEET 2 AD6 2 LEU L 323 ALA L 324 -1 O LEU L 323 N VAL L 40 SHEET 1 AD7 3 LEU L 43 GLU L 44 0 SHEET 2 AD7 3 PHE L 301 GLN L 302 1 O PHE L 301 N GLU L 44 SHEET 3 AD7 3 LYS L 314 TYR L 315 1 O LYS L 314 N GLN L 302 SHEET 1 AD8 3 ILE L 60 LEU L 62 0 SHEET 2 AD8 3 ILE L 89 GLU L 91 1 O VAL L 90 N LEU L 62 SHEET 3 AD8 3 LEU L 274 ARG L 276 1 O PHE L 275 N ILE L 89 SHEET 1 AD9 5 GLY L 103 LEU L 105 0 SHEET 2 AD9 5 ARG L 235 VAL L 243 1 O PHE L 238 N THR L 104 SHEET 3 AD9 5 VAL L 182 HIS L 190 -1 N VAL L 182 O VAL L 243 SHEET 4 AD9 5 TYR L 262 VAL L 269 -1 O PHE L 264 N LEU L 183 SHEET 5 AD9 5 VAL L 118 GLU L 125 -1 N GLU L 120 O SER L 268 SHEET 1 AE1 5 GLY L 103 LEU L 105 0 SHEET 2 AE1 5 ARG L 235 VAL L 243 1 O PHE L 238 N THR L 104 SHEET 3 AE1 5 VAL L 182 HIS L 190 -1 N VAL L 182 O VAL L 243 SHEET 4 AE1 5 PHE L 257 PRO L 260 -1 O LEU L 258 N GLY L 187 SHEET 5 AE1 5 MET L 157 TRP L 159 -1 N VAL L 158 O ALA L 259 SHEET 1 AE2 2 THR L 142 LYS L 146 0 SHEET 2 AE2 2 ASN L 151 SER L 152 -1 O SER L 152 N THR L 142 SHEET 1 AE3 4 ILE L 170 ASN L 175 0 SHEET 2 AE3 4 SER L 248 SER L 253 -1 O SER L 253 N ILE L 170 SHEET 3 AE3 4 VAL L 208 SER L 212 -1 N GLY L 211 O THR L 250 SHEET 4 AE3 4 ASN L 216 PHE L 219 -1 O PHE L 219 N VAL L 208 SHEET 1 AE4 2 CYS L 288 GLN L 289 0 SHEET 2 AE4 2 ALA L 294 ILE L 295 -1 O ILE L 295 N CYS L 288 SHEET 1 AE5 3 MET M 4 SER M 7 0 SHEET 2 AE5 3 VAL M 19 ILE M 29 -1 O ARG M 24 N THR M 5 SHEET 3 AE5 3 PHE M 62 ILE M 75 -1 O GLY M 68 N ILE M 29 SHEET 1 AE6 6 THR M 10 SER M 14 0 SHEET 2 AE6 6 THR M 102 LYS M 107 1 O GLU M 105 N LEU M 11 SHEET 3 AE6 6 ALA M 84 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AE6 6 LEU M 33 GLN M 38 -1 N GLN M 38 O ILE M 85 SHEET 5 AE6 6 LYS M 45 TYR M 49 -1 O LYS M 45 N GLN M 37 SHEET 6 AE6 6 SER M 53 LEU M 54 -1 O SER M 53 N TYR M 49 SHEET 1 AE7 4 THR M 10 SER M 14 0 SHEET 2 AE7 4 THR M 102 LYS M 107 1 O GLU M 105 N LEU M 11 SHEET 3 AE7 4 ALA M 84 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AE7 4 THR M 97 PHE M 98 -1 O THR M 97 N GLN M 90 SHEET 1 AE8 4 SER M 114 PHE M 118 0 SHEET 2 AE8 4 SER M 131 PHE M 139 -1 O ASN M 137 N SER M 114 SHEET 3 AE8 4 TYR M 173 THR M 180 -1 O TYR M 173 N PHE M 139 SHEET 4 AE8 4 SER M 159 VAL M 163 -1 N SER M 162 O SER M 176 SHEET 1 AE9 4 ALA M 153 LEU M 154 0 SHEET 2 AE9 4 ALA M 144 VAL M 150 -1 N VAL M 150 O ALA M 153 SHEET 3 AE9 4 TYR M 192 HIS M 198 -1 O THR M 197 N LYS M 145 SHEET 4 AE9 4 VAL M 205 PHE M 209 -1 O LYS M 207 N CYS M 194 SHEET 1 AF1 4 LEU N 4 SER N 7 0 SHEET 2 AF1 4 LEU N 18 VAL N 24 -1 O SER N 23 N GLN N 5 SHEET 3 AF1 4 GLN N 77 LEU N 82 -1 O PHE N 78 N CYS N 22 SHEET 4 AF1 4 VAL N 67 ASP N 72 -1 N ASP N 72 O GLN N 77 SHEET 1 AF2 6 LEU N 11 VAL N 12 0 SHEET 2 AF2 6 THR N 115 VAL N 119 1 O THR N 118 N VAL N 12 SHEET 3 AF2 6 ALA N 91 GLU N 98 -1 N ALA N 91 O VAL N 117 SHEET 4 AF2 6 TYR N 33 GLN N 39 -1 N ILE N 37 O TYR N 94 SHEET 5 AF2 6 GLU N 46 PHE N 51 -1 O PHE N 51 N TRP N 34 SHEET 6 AF2 6 ASN N 58 TYR N 59 -1 O ASN N 58 N ARG N 50 SHEET 1 AF3 4 VAL N 129 LEU N 132 0 SHEET 2 AF3 4 THR N 143 VAL N 150 -1 O GLY N 147 N LEU N 132 SHEET 3 AF3 4 TYR N 184 PRO N 193 -1 O LEU N 186 N VAL N 150 SHEET 4 AF3 4 VAL N 171 THR N 173 -1 N HIS N 172 O VAL N 189 SHEET 1 AF4 4 VAL N 129 LEU N 132 0 SHEET 2 AF4 4 THR N 143 VAL N 150 -1 O GLY N 147 N LEU N 132 SHEET 3 AF4 4 TYR N 184 PRO N 193 -1 O LEU N 186 N VAL N 150 SHEET 4 AF4 4 VAL N 177 LEU N 178 -1 N VAL N 177 O SER N 185 SHEET 1 AF5 3 VAL N 158 TRP N 162 0 SHEET 2 AF5 3 ILE N 203 HIS N 208 -1 O ASN N 207 N THR N 159 SHEET 3 AF5 3 THR N 213 ARG N 218 -1 O VAL N 215 N VAL N 206 SHEET 1 AF6 4 GLY P 13 TRP P 14 0 SHEET 2 AF6 4 THR Q 12 HIS Q 18 1 O TYR Q 17 N TRP P 14 SHEET 3 AF6 4 TYR P 22 ASN P 28 -1 N GLN P 27 O THR Q 12 SHEET 4 AF6 4 GLY P 31 ALA P 36 -1 O ALA P 35 N TYR P 24 SHEET 1 AF7 4 GLY P 13 TRP P 14 0 SHEET 2 AF7 4 THR Q 12 HIS Q 18 1 O TYR Q 17 N TRP P 14 SHEET 3 AF7 4 CYS P 137 PHE P 140 -1 N PHE P 138 O LEU Q 13 SHEET 4 AF7 4 ALA P 130 GLU P 132 -1 N LYS P 131 O GLU P 139 SHEET 1 AF8 2 THR Q 25 VAL Q 26 0 SHEET 2 AF8 2 VAL Q 34 THR Q 35 -1 O VAL Q 34 N VAL Q 26 SHEET 1 AF9 2 SER Q 39 ASN Q 41 0 SHEET 2 AF9 2 ARG Q 322 ALA Q 324 -1 O LEU Q 323 N VAL Q 40 SHEET 1 AG1 3 LEU Q 43 GLU Q 44 0 SHEET 2 AG1 3 PHE Q 301 GLN Q 302 1 O PHE Q 301 N GLU Q 44 SHEET 3 AG1 3 LYS Q 314 TYR Q 315 1 O LYS Q 314 N GLN Q 302 SHEET 1 AG2 3 ILE Q 60 SER Q 61 0 SHEET 2 AG2 3 ILE Q 89 VAL Q 90 1 O VAL Q 90 N ILE Q 60 SHEET 3 AG2 3 LEU Q 274 PHE Q 275 1 O PHE Q 275 N ILE Q 89 SHEET 1 AG3 5 GLY Q 103 LEU Q 105 0 SHEET 2 AG3 5 ARG Q 235 VAL Q 243 1 O PHE Q 238 N THR Q 104 SHEET 3 AG3 5 VAL Q 182 HIS Q 190 -1 N HIS Q 190 O ARG Q 235 SHEET 4 AG3 5 TYR Q 262 VAL Q 269 -1 O PHE Q 264 N LEU Q 183 SHEET 5 AG3 5 VAL Q 118 GLU Q 125 -1 N LEU Q 119 O SER Q 268 SHEET 1 AG4 2 MET Q 157 TRP Q 159 0 SHEET 2 AG4 2 LEU Q 258 PRO Q 260 -1 O ALA Q 259 N VAL Q 158 SHEET 1 AG5 4 ILE Q 170 ASN Q 175 0 SHEET 2 AG5 4 SER Q 248 SER Q 253 -1 O PHE Q 251 N ARG Q 172 SHEET 3 AG5 4 VAL Q 208 SER Q 212 -1 N ALA Q 209 O GLU Q 252 SHEET 4 AG5 4 ASN Q 216 PHE Q 219 -1 O PHE Q 219 N VAL Q 208 SHEET 1 AG6 2 CYS Q 288 GLN Q 289 0 SHEET 2 AG6 2 ILE Q 309 GLY Q 310 -1 O ILE Q 309 N GLN Q 289 SHEET 1 AG7 4 MET R 4 SER R 7 0 SHEET 2 AG7 4 VAL R 19 ALA R 25 -1 O ARG R 24 N THR R 5 SHEET 3 AG7 4 GLU R 70 ILE R 75 -1 O PHE R 71 N CYS R 23 SHEET 4 AG7 4 PHE R 62 SER R 67 -1 N SER R 63 O THR R 74 SHEET 1 AG8 6 THR R 10 SER R 12 0 SHEET 2 AG8 6 THR R 102 GLU R 105 1 O LYS R 103 N LEU R 11 SHEET 3 AG8 6 ALA R 84 GLN R 90 -1 N TYR R 86 O THR R 102 SHEET 4 AG8 6 LEU R 33 GLN R 38 -1 N GLN R 38 O ILE R 85 SHEET 5 AG8 6 PRO R 44 TYR R 49 -1 O LEU R 47 N TRP R 35 SHEET 6 AG8 6 SER R 53 LEU R 54 -1 O SER R 53 N TYR R 49 SHEET 1 AG9 4 SER R 114 PHE R 118 0 SHEET 2 AG9 4 SER R 131 PHE R 139 -1 O VAL R 133 N PHE R 118 SHEET 3 AG9 4 TYR R 173 THR R 180 -1 O TYR R 173 N PHE R 139 SHEET 4 AG9 4 SER R 159 VAL R 163 -1 N SER R 162 O SER R 176 SHEET 1 AH1 4 ALA R 153 LEU R 154 0 SHEET 2 AH1 4 ALA R 144 VAL R 150 -1 N VAL R 150 O ALA R 153 SHEET 3 AH1 4 VAL R 191 HIS R 198 -1 O ALA R 193 N LYS R 149 SHEET 4 AH1 4 VAL R 205 ASN R 210 -1 O LYS R 207 N CYS R 194 SHEET 1 AH2 4 GLN S 3 SER S 7 0 SHEET 2 AH2 4 LEU S 18 SER S 25 -1 O SER S 25 N GLN S 3 SHEET 3 AH2 4 GLN S 77 LEU S 82 -1 O PHE S 78 N CYS S 22 SHEET 4 AH2 4 VAL S 67 ASP S 72 -1 N ASP S 72 O GLN S 77 SHEET 1 AH3 6 LEU S 11 VAL S 12 0 SHEET 2 AH3 6 THR S 115 VAL S 119 1 O THR S 118 N VAL S 12 SHEET 3 AH3 6 ALA S 91 GLU S 98 -1 N ALA S 91 O VAL S 117 SHEET 4 AH3 6 TYR S 33 GLN S 39 -1 N ILE S 37 O TYR S 94 SHEET 5 AH3 6 GLU S 46 PHE S 51 -1 O PHE S 51 N TRP S 34 SHEET 6 AH3 6 ASN S 58 TYR S 59 -1 O ASN S 58 N ARG S 50 SHEET 1 AH4 4 SER S 128 LEU S 132 0 SHEET 2 AH4 4 THR S 143 LYS S 151 -1 O LYS S 151 N SER S 128 SHEET 3 AH4 4 TYR S 184 PRO S 193 -1 O LEU S 186 N VAL S 150 SHEET 4 AH4 4 VAL S 171 THR S 173 -1 N HIS S 172 O VAL S 189 SHEET 1 AH5 4 SER S 128 LEU S 132 0 SHEET 2 AH5 4 THR S 143 LYS S 151 -1 O LYS S 151 N SER S 128 SHEET 3 AH5 4 TYR S 184 PRO S 193 -1 O LEU S 186 N VAL S 150 SHEET 4 AH5 4 VAL S 177 LEU S 178 -1 N VAL S 177 O SER S 185 SHEET 1 AH6 3 VAL S 158 TRP S 162 0 SHEET 2 AH6 3 ILE S 203 HIS S 208 -1 O ASN S 205 N SER S 161 SHEET 3 AH6 3 THR S 213 ARG S 218 -1 O VAL S 215 N VAL S 206 SHEET 1 AH7 4 GLY U 13 TRP U 14 0 SHEET 2 AH7 4 THR V 12 HIS V 18 1 O TYR V 17 N TRP U 14 SHEET 3 AH7 4 TYR U 22 ASN U 28 -1 N GLN U 27 O THR V 12 SHEET 4 AH7 4 GLY U 31 ALA U 36 -1 O GLY U 31 N ASN U 28 SHEET 1 AH8 4 GLY U 13 TRP U 14 0 SHEET 2 AH8 4 THR V 12 HIS V 18 1 O TYR V 17 N TRP U 14 SHEET 3 AH8 4 CYS U 137 PHE U 140 -1 N PHE U 138 O LEU V 13 SHEET 4 AH8 4 ALA U 130 LYS U 131 -1 N LYS U 131 O GLU U 139 SHEET 1 AH9 2 THR V 25 VAL V 26 0 SHEET 2 AH9 2 VAL V 34 THR V 35 -1 O VAL V 34 N VAL V 26 SHEET 1 AI1 2 SER V 39 ASN V 41 0 SHEET 2 AI1 2 ARG V 322 ALA V 324 -1 O LEU V 323 N VAL V 40 SHEET 1 AI2 2 LEU V 51 SER V 53 0 SHEET 2 AI2 2 ILE V 281 ASN V 285 1 O GLU V 282 N SER V 53 SHEET 1 AI3 3 ILE V 60 SER V 61 0 SHEET 2 AI3 3 ILE V 89 VAL V 90 1 O VAL V 90 N ILE V 60 SHEET 3 AI3 3 LEU V 274 PHE V 275 1 O PHE V 275 N ILE V 89 SHEET 1 AI4 5 THR V 104 LEU V 105 0 SHEET 2 AI4 5 ARG V 235 VAL V 243 1 O PHE V 238 N THR V 104 SHEET 3 AI4 5 VAL V 182 HIS V 190 -1 N HIS V 190 O ARG V 235 SHEET 4 AI4 5 TYR V 262 GLU V 265 -1 O PHE V 264 N LEU V 183 SHEET 5 AI4 5 PHE V 124 GLU V 125 -1 N PHE V 124 O ALA V 263 SHEET 1 AI5 5 THR V 104 LEU V 105 0 SHEET 2 AI5 5 ARG V 235 VAL V 243 1 O PHE V 238 N THR V 104 SHEET 3 AI5 5 VAL V 182 HIS V 190 -1 N HIS V 190 O ARG V 235 SHEET 4 AI5 5 PHE V 257 PRO V 260 -1 O LEU V 258 N GLY V 187 SHEET 5 AI5 5 MET V 157 TRP V 159 -1 N VAL V 158 O ALA V 259 SHEET 1 AI6 2 VAL V 118 GLU V 120A 0 SHEET 2 AI6 2 SER V 268 VAL V 269 -1 O SER V 268 N GLU V 120A SHEET 1 AI7 2 VAL V 135 ASN V 136 0 SHEET 2 AI7 2 ILE V 161 HIS V 162 -1 O ILE V 161 N ASN V 136 SHEET 1 AI8 2 THR V 142 PHE V 147 0 SHEET 2 AI8 2 SER V 150 SER V 152 -1 O SER V 150 N PHE V 147 SHEET 1 AI9 4 ILE V 170 ASN V 175 0 SHEET 2 AI9 4 SER V 248 SER V 253 -1 O PHE V 251 N ARG V 172 SHEET 3 AI9 4 VAL V 208 GLY V 211 -1 N GLY V 211 O THR V 250 SHEET 4 AI9 4 ARG V 218 PHE V 219 -1 O PHE V 219 N VAL V 208 SHEET 1 AJ1 2 PHE V 301 GLN V 302 0 SHEET 2 AJ1 2 LYS V 314 TYR V 315 1 O LYS V 314 N GLN V 302 SHEET 1 AJ2 4 MET W 4 SER W 7 0 SHEET 2 AJ2 4 VAL W 19 ALA W 25 -1 O THR W 22 N SER W 7 SHEET 3 AJ2 4 GLU W 70 ILE W 75 -1 O PHE W 71 N CYS W 23 SHEET 4 AJ2 4 PHE W 62 SER W 67 -1 N SER W 65 O THR W 72 SHEET 1 AJ3 6 THR W 10 SER W 12 0 SHEET 2 AJ3 6 THR W 102 GLU W 105 1 O GLU W 105 N LEU W 11 SHEET 3 AJ3 6 ALA W 84 CYS W 88 -1 N ALA W 84 O VAL W 104 SHEET 4 AJ3 6 LEU W 33 GLN W 38 -1 N GLN W 38 O ILE W 85 SHEET 5 AJ3 6 LYS W 45 TYR W 49 -1 O LEU W 47 N TRP W 35 SHEET 6 AJ3 6 SER W 53 LEU W 54 -1 O SER W 53 N TYR W 49 SHEET 1 AJ4 4 PHE W 116 ILE W 117 0 SHEET 2 AJ4 4 VAL W 133 LEU W 135 -1 O LEU W 135 N PHE W 116 SHEET 3 AJ4 4 SER W 174 THR W 178 -1 O SER W 177 N CYS W 134 SHEET 4 AJ4 4 GLN W 160 THR W 164 -1 N SER W 162 O SER W 176 SHEET 1 AJ5 3 LYS W 145 LYS W 149 0 SHEET 2 AJ5 3 ALA W 193 THR W 197 -1 O GLU W 195 N GLN W 147 SHEET 3 AJ5 3 VAL W 205 SER W 208 -1 O LYS W 207 N CYS W 194 SHEET 1 AJ6 4 GLN X 3 SER X 7 0 SHEET 2 AJ6 4 LEU X 18 SER X 25 -1 O THR X 21 N SER X 7 SHEET 3 AJ6 4 GLN X 77 LEU X 82 -1 O PHE X 78 N CYS X 22 SHEET 4 AJ6 4 VAL X 67 ASP X 72 -1 N SER X 70 O SER X 79 SHEET 1 AJ7 5 ASN X 58 TYR X 59 0 SHEET 2 AJ7 5 GLU X 46 PHE X 51 -1 N ARG X 50 O ASN X 58 SHEET 3 AJ7 5 TYR X 33 PRO X 40 -1 N TRP X 34 O PHE X 51 SHEET 4 AJ7 5 ALA X 91 GLU X 98 -1 O TYR X 94 N ILE X 37 SHEET 5 AJ7 5 THR X 115 VAL X 117 -1 O THR X 115 N TYR X 93 SHEET 1 AJ8 4 SER X 128 LEU X 132 0 SHEET 2 AJ8 4 THR X 143 TYR X 153 -1 O LYS X 151 N SER X 128 SHEET 3 AJ8 4 TYR X 184 PRO X 193 -1 O LEU X 186 N VAL X 150 SHEET 4 AJ8 4 VAL X 177 LEU X 178 -1 N VAL X 177 O SER X 185 SHEET 1 AJ9 3 VAL X 160 TRP X 162 0 SHEET 2 AJ9 3 TYR X 202 HIS X 208 -1 O ASN X 205 N SER X 161 SHEET 3 AJ9 3 THR X 213 VAL X 219 -1 O LYS X 217 N CYS X 204 SHEET 1 AK1 2 THR Y 25 VAL Y 26 0 SHEET 2 AK1 2 VAL Y 34 THR Y 35 -1 O VAL Y 34 N VAL Y 26 SHEET 1 AK2 2 SER Y 39 ASN Y 41 0 SHEET 2 AK2 2 ARG Y 322 ALA Y 324 -1 O LEU Y 323 N VAL Y 40 SHEET 1 AK3 3 LEU Y 43 GLU Y 44 0 SHEET 2 AK3 3 PHE Y 301 GLN Y 302 1 O PHE Y 301 N GLU Y 44 SHEET 3 AK3 3 LYS Y 314 TYR Y 315 1 O LYS Y 314 N GLN Y 302 SHEET 1 AK4 3 ILE Y 60 SER Y 61 0 SHEET 2 AK4 3 ILE Y 89 VAL Y 90 1 O VAL Y 90 N ILE Y 60 SHEET 3 AK4 3 LEU Y 274 PHE Y 275 1 O PHE Y 275 N ILE Y 89 SHEET 1 AK5 5 GLY Y 103 LEU Y 105 0 SHEET 2 AK5 5 ARG Y 235 VAL Y 243 1 O PHE Y 238 N THR Y 104 SHEET 3 AK5 5 VAL Y 182 HIS Y 190 -1 N VAL Y 182 O VAL Y 243 SHEET 4 AK5 5 TYR Y 262 SER Y 268 -1 O PHE Y 264 N LEU Y 183 SHEET 5 AK5 5 GLU Y 120 GLU Y 125 -1 N SER Y 122 O GLU Y 265 SHEET 1 AK6 5 GLY Y 103 LEU Y 105 0 SHEET 2 AK6 5 ARG Y 235 VAL Y 243 1 O PHE Y 238 N THR Y 104 SHEET 3 AK6 5 VAL Y 182 HIS Y 190 -1 N VAL Y 182 O VAL Y 243 SHEET 4 AK6 5 PHE Y 257 PRO Y 260 -1 O LEU Y 258 N GLY Y 187 SHEET 5 AK6 5 MET Y 157 TRP Y 159 -1 N VAL Y 158 O ALA Y 259 SHEET 1 AK7 4 ILE Y 170 ASN Y 175 0 SHEET 2 AK7 4 SER Y 248 SER Y 253 -1 O PHE Y 251 N ARG Y 172 SHEET 3 AK7 4 VAL Y 208 GLY Y 211 -1 N GLY Y 211 O THR Y 250 SHEET 4 AK7 4 ASN Y 216 PHE Y 219 -1 O ARG Y 217 N VAL Y 210 SHEET 1 AK8 2 CYS Y 288 GLN Y 289 0 SHEET 2 AK8 2 ILE Y 309 GLY Y 310 -1 O ILE Y 309 N GLN Y 289 SHEET 1 AK9 5 GLY a 31 ALA a 36 0 SHEET 2 AK9 5 TYR a 22 ASN a 28 -1 N ASN a 28 O GLY a 31 SHEET 3 AK9 5 THR b 12 TYR b 17 -1 O CYS b 14 N HIS a 25 SHEET 4 AK9 5 CYS a 137 PHE a 140 -1 N PHE a 138 O LEU b 13 SHEET 5 AK9 5 ALA a 130 ILE a 133 -1 N ILE a 133 O CYS a 137 SHEET 1 AL1 2 THR b 25 VAL b 26 0 SHEET 2 AL1 2 VAL b 34 THR b 35 -1 O VAL b 34 N VAL b 26 SHEET 1 AL2 2 SER b 39 ASN b 41 0 SHEET 2 AL2 2 ARG b 323 ALA b 325 -1 O LEU b 324 N VAL b 40 SHEET 1 AL3 3 LEU b 43 GLU b 44 0 SHEET 2 AL3 3 PHE b 302 GLN b 303 1 O PHE b 302 N GLU b 44 SHEET 3 AL3 3 LYS b 315 TYR b 316 1 O LYS b 315 N GLN b 303 SHEET 1 AL4 5 GLY b 103 LEU b 105 0 SHEET 2 AL4 5 ARG b 236 VAL b 244 1 O PHE b 239 N THR b 104 SHEET 3 AL4 5 VAL b 183 HIS b 191 -1 N HIS b 191 O ARG b 236 SHEET 4 AL4 5 TYR b 263 GLU b 266 -1 O PHE b 265 N LEU b 184 SHEET 5 AL4 5 PHE b 124 GLU b 125 -1 N PHE b 124 O ALA b 264 SHEET 1 AL5 5 GLY b 103 LEU b 105 0 SHEET 2 AL5 5 ARG b 236 VAL b 244 1 O PHE b 239 N THR b 104 SHEET 3 AL5 5 VAL b 183 HIS b 191 -1 N HIS b 191 O ARG b 236 SHEET 4 AL5 5 PHE b 258 PRO b 261 -1 O LEU b 259 N GLY b 188 SHEET 5 AL5 5 MET b 158 TRP b 160 -1 N VAL b 159 O ALA b 260 SHEET 1 AL6 2 THR b 143 PHE b 148 0 SHEET 2 AL6 2 SER b 151 SER b 153 -1 O SER b 151 N PHE b 148 SHEET 1 AL7 4 ILE b 171 ASN b 176 0 SHEET 2 AL7 4 SER b 249 SER b 254 -1 O PHE b 252 N ARG b 173 SHEET 3 AL7 4 VAL b 209 GLY b 212 -1 N GLY b 212 O THR b 251 SHEET 4 AL7 4 ASN b 217 PHE b 220 -1 O PHE b 220 N VAL b 209 SHEET 1 AL8 2 CYS b 289 GLN b 290 0 SHEET 2 AL8 2 ALA b 295 ILE b 296 -1 O ILE b 296 N CYS b 289 SHEET 1 AL9 4 MET c 4 SER c 7 0 SHEET 2 AL9 4 VAL c 19 ALA c 25 -1 O ARG c 24 N THR c 5 SHEET 3 AL9 4 GLU c 70 ILE c 75 -1 O LEU c 73 N ILE c 21 SHEET 4 AL9 4 PHE c 62 SER c 67 -1 N SER c 63 O THR c 74 SHEET 1 AM1 6 THR c 10 SER c 14 0 SHEET 2 AM1 6 THR c 102 LYS c 107 1 O GLU c 105 N LEU c 11 SHEET 3 AM1 6 ALA c 84 GLN c 90 -1 N TYR c 86 O THR c 102 SHEET 4 AM1 6 LEU c 33 GLN c 38 -1 N GLN c 38 O ILE c 85 SHEET 5 AM1 6 PRO c 44 TYR c 49 -1 O LEU c 47 N TRP c 35 SHEET 6 AM1 6 SER c 53 LEU c 54 -1 O SER c 53 N TYR c 49 SHEET 1 AM2 4 THR c 10 SER c 14 0 SHEET 2 AM2 4 THR c 102 LYS c 107 1 O GLU c 105 N LEU c 11 SHEET 3 AM2 4 ALA c 84 GLN c 90 -1 N TYR c 86 O THR c 102 SHEET 4 AM2 4 THR c 97 PHE c 98 -1 O THR c 97 N GLN c 90 SHEET 1 AM3 4 SER c 114 PHE c 118 0 SHEET 2 AM3 4 SER c 131 PHE c 139 -1 O VAL c 133 N PHE c 118 SHEET 3 AM3 4 TYR c 173 THR c 180 -1 O LEU c 175 N LEU c 136 SHEET 4 AM3 4 SER c 159 VAL c 163 -1 N SER c 162 O SER c 176 SHEET 1 AM4 4 ALA c 153 LEU c 154 0 SHEET 2 AM4 4 LYS c 145 VAL c 150 -1 N VAL c 150 O ALA c 153 SHEET 3 AM4 4 TYR c 192 THR c 197 -1 O ALA c 193 N LYS c 149 SHEET 4 AM4 4 VAL c 205 PHE c 209 -1 O VAL c 205 N VAL c 196 SHEET 1 AM5 4 GLN d 3 SER d 7 0 SHEET 2 AM5 4 LEU d 18 SER d 25 -1 O SER d 23 N GLN d 5 SHEET 3 AM5 4 GLN d 77 LEU d 82 -1 O PHE d 78 N CYS d 22 SHEET 4 AM5 4 VAL d 67 ASP d 72 -1 N ASP d 72 O GLN d 77 SHEET 1 AM6 6 LEU d 11 VAL d 12 0 SHEET 2 AM6 6 THR d 115 VAL d 119 1 O THR d 118 N VAL d 12 SHEET 3 AM6 6 ALA d 91 GLU d 98 -1 N ALA d 91 O VAL d 117 SHEET 4 AM6 6 TYR d 33 GLN d 39 -1 N ILE d 35 O ALA d 96 SHEET 5 AM6 6 GLU d 46 PHE d 51 -1 O GLU d 46 N ARG d 38 SHEET 6 AM6 6 ASN d 58 TYR d 59 -1 O ASN d 58 N ARG d 50 SHEET 1 AM7 2 ILE d 101 THR d 102 0 SHEET 2 AM7 2 GLY d 105 VAL d 106 -1 O GLY d 105 N THR d 102 SHEET 1 AM8 4 SER d 128 LEU d 132 0 SHEET 2 AM8 4 ALA d 144 TYR d 153 -1 O GLY d 147 N LEU d 132 SHEET 3 AM8 4 TYR d 184 VAL d 192 -1 O LEU d 186 N VAL d 150 SHEET 4 AM8 4 VAL d 171 THR d 173 -1 N HIS d 172 O VAL d 189 SHEET 1 AM9 4 SER d 128 LEU d 132 0 SHEET 2 AM9 4 ALA d 144 TYR d 153 -1 O GLY d 147 N LEU d 132 SHEET 3 AM9 4 TYR d 184 VAL d 192 -1 O LEU d 186 N VAL d 150 SHEET 4 AM9 4 VAL d 177 LEU d 178 -1 N VAL d 177 O SER d 185 SHEET 1 AN1 3 VAL d 160 TRP d 162 0 SHEET 2 AN1 3 ILE d 203 VAL d 206 -1 O ASN d 205 N SER d 161 SHEET 3 AN1 3 ASP d 216 ARG d 218 -1 O LYS d 217 N CYS d 204 SSBOND 1 CYS B 137 CYS C 14 1555 1555 2.04 SSBOND 2 CYS B 144 CYS B 148 1555 1555 2.03 SSBOND 3 CYS C 65 CYS C 77 1555 1555 2.03 SSBOND 4 CYS C 288 CYS C 312 1555 1555 2.03 SSBOND 5 CYS D 23 CYS D 88 1555 1555 2.04 SSBOND 6 CYS D 134 CYS D 194 1555 1555 2.03 SSBOND 7 CYS E 22 CYS E 95 1555 1555 2.04 SSBOND 8 CYS H 137 CYS L 14 1555 1555 2.03 SSBOND 9 CYS H 144 CYS H 148 1555 1555 2.03 SSBOND 10 CYS I 137 CYS Y 14 1555 1555 2.03 SSBOND 11 CYS I 144 CYS I 148 1555 1555 2.04 SSBOND 12 CYS J 23 CYS J 88 1555 1555 2.04 SSBOND 13 CYS J 134 CYS J 194 1555 1555 2.03 SSBOND 14 CYS K 22 CYS K 95 1555 1555 2.04 SSBOND 15 CYS L 65 CYS L 77 1555 1555 2.03 SSBOND 16 CYS L 288 CYS L 312 1555 1555 2.03 SSBOND 17 CYS M 23 CYS M 88 1555 1555 2.04 SSBOND 18 CYS M 134 CYS M 194 1555 1555 2.03 SSBOND 19 CYS N 22 CYS N 95 1555 1555 2.04 SSBOND 20 CYS P 137 CYS Q 14 1555 1555 2.03 SSBOND 21 CYS P 144 CYS P 148 1555 1555 2.03 SSBOND 22 CYS Q 52 CYS Q 284 1555 1555 2.02 SSBOND 23 CYS Q 65 CYS Q 77 1555 1555 2.03 SSBOND 24 CYS R 23 CYS R 88 1555 1555 2.04 SSBOND 25 CYS R 134 CYS R 194 1555 1555 2.03 SSBOND 26 CYS S 22 CYS S 95 1555 1555 2.03 SSBOND 27 CYS U 137 CYS V 14 1555 1555 2.03 SSBOND 28 CYS U 144 CYS U 148 1555 1555 2.03 SSBOND 29 CYS V 65 CYS V 77 1555 1555 2.03 SSBOND 30 CYS V 288 CYS V 312 1555 1555 2.02 SSBOND 31 CYS W 23 CYS W 88 1555 1555 2.04 SSBOND 32 CYS W 134 CYS W 194 1555 1555 2.03 SSBOND 33 CYS X 22 CYS X 95 1555 1555 2.04 SSBOND 34 CYS Y 52 CYS Y 284 1555 1555 2.04 SSBOND 35 CYS Y 65 CYS Y 77 1555 1555 2.03 SSBOND 36 CYS Y 288 CYS Y 312 1555 1555 2.03 SSBOND 37 CYS a 137 CYS b 14 1555 1555 2.03 SSBOND 38 CYS a 144 CYS a 148 1555 1555 2.03 SSBOND 39 CYS c 23 CYS c 88 1555 1555 2.03 SSBOND 40 CYS c 134 CYS c 194 1555 1555 2.04 SSBOND 41 CYS d 22 CYS d 95 1555 1555 2.03 SSBOND 42 CYS d 148 CYS d 204 1555 1555 2.03 LINK O4 NAG A 1 C1 NAG A 2 1555 1555 1.44 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG F 2 C1 BMA F 3 1555 1555 1.45 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.45 LINK O4 NAG G 2 C1 BMA G 3 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.47 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.45 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.45 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.45 LINK O4 NAG e 2 C1 BMA e 3 1555 1555 1.45 CISPEP 1 SER D 7 PRO D 8 0 -4.13 CISPEP 2 TYR D 94 PRO D 95 0 2.36 CISPEP 3 TYR D 140 PRO D 141 0 1.72 CISPEP 4 SER J 7 PRO J 8 0 -2.28 CISPEP 5 TYR J 94 PRO J 95 0 1.86 CISPEP 6 TYR J 140 PRO J 141 0 0.66 CISPEP 7 SER M 7 PRO M 8 0 -5.69 CISPEP 8 TYR M 94 PRO M 95 0 2.37 CISPEP 9 TYR M 140 PRO M 141 0 0.43 CISPEP 10 SER R 7 PRO R 8 0 -0.65 CISPEP 11 TYR R 94 PRO R 95 0 0.46 CISPEP 12 TYR R 140 PRO R 141 0 -2.21 CISPEP 13 SER W 7 PRO W 8 0 -0.98 CISPEP 14 TYR W 94 PRO W 95 0 -5.82 CISPEP 15 TYR W 140 PRO W 141 0 -2.49 CISPEP 16 SER c 7 PRO c 8 0 -5.79 CISPEP 17 TYR c 94 PRO c 95 0 1.91 CISPEP 18 TYR c 140 PRO c 141 0 2.38 CRYST1 182.433 194.500 214.733 90.00 90.00 90.00 P 21 21 21 48 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.005481 0.000000 0.000000 0.00000 SCALE2 0.000000 0.005141 0.000000 0.00000 SCALE3 0.000000 0.000000 0.004657 0.00000