HEADER VIRAL PROTEIN/IMMUNE SYSTEM 18-JUN-24 9CB1 TITLE CRYO-EM STRUCTURE OF THE HUMAN NEUTRALIZING ANTIBODY 5-1 IN COMPLEX TITLE 2 WITH PREFUSION HUMAN METAPNEUMOVIRUS F GLYCOPROTEIN COMPND MOL_ID: 1; COMPND 2 MOLECULE: 5-1 FAB HEAVY CHAIN VARIABLE DOMAIN; COMPND 3 CHAIN: A, B, C; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: 5-1 FAB LIGHT CHAIN VARIABLE DOMAIN; COMPND 7 CHAIN: D, E, F; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: FUSION GLYCOPROTEIN F0; COMPND 11 CHAIN: G, H, I; COMPND 12 SYNONYM: F-DSCAVES2-IPDS; COMPND 13 ENGINEERED: YES; COMPND 14 MUTATION: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 CELL_LINE: EXPI293F; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 11 ORGANISM_COMMON: HUMAN; SOURCE 12 ORGANISM_TAXID: 9606; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 MOL_ID: 3; SOURCE 17 ORGANISM_SCIENTIFIC: HUMAN METAPNEUMOVIRUS; SOURCE 18 ORGANISM_COMMON: HMPV; SOURCE 19 ORGANISM_TAXID: 162145; SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 21 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS HMPV F, 5-1 ANTIBODY, ANTIBODY, VIRAL PROTEIN-IMMUNE SYSTEM, VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR L.Q.GUO,J.S.MCLELLAN REVDAT 1 28-MAY-25 9CB1 0 JRNL AUTH A.A.ABU-SHMAIS,L.Q.GUO,R.J.MILLER,J.K.JANKE,M.J.VUKOVICH, JRNL AUTH 2 E.B.LINDSAY,S.A.RUSH,R.M.WOLTER,N.KOSE,R.H.CARNAHAN, JRNL AUTH 3 J.E.CROWE,R.H.BONAMI,J.J.MOUSA,J.S.MCLELLAN,I.S.GEORGIEV JRNL TITL POTENT CROSS-NEUTRALIZING RSV/HMPV ANTIBODY TARGETING JRNL TITL 2 ANTIGENIC SITE V JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 4.24 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.240 REMARK 3 NUMBER OF PARTICLES : 18483 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9CB1 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-JUN-24. REMARK 100 THE DEPOSITION ID IS D_1000285099. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : THE PROTEIN COMPLEX OF HMPV F REMARK 245 -DSCAVES2-IPDS AND 5-1 FAB; REMARK 245 HMPV F-DSCAVES2-IPDS TRIMER; 5- REMARK 245 1 FAB HEAVY CHAIN VARIABLE REMARK 245 DOMAIN; 5-1 FAB LIGHT CHAIN REMARK 245 VARIABLE DOMAIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4864.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 150000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER A 112 REMARK 465 SER A 113 REMARK 465 ALA A 114 REMARK 465 SER A 115 REMARK 465 THR A 116 REMARK 465 LYS A 117 REMARK 465 GLY A 118 REMARK 465 PRO A 119 REMARK 465 SER A 120 REMARK 465 VAL A 121 REMARK 465 PHE A 122 REMARK 465 PRO A 123 REMARK 465 LEU A 124 REMARK 465 ALA A 125 REMARK 465 PRO A 126 REMARK 465 SER A 127 REMARK 465 SER A 128 REMARK 465 LYS A 129 REMARK 465 SER A 130 REMARK 465 THR A 131 REMARK 465 SER A 132 REMARK 465 GLY A 133 REMARK 465 GLY A 134 REMARK 465 THR A 135 REMARK 465 ALA A 136 REMARK 465 ALA A 137 REMARK 465 LEU A 138 REMARK 465 GLY A 139 REMARK 465 CYS A 140 REMARK 465 LEU A 141 REMARK 465 VAL A 142 REMARK 465 LYS A 143 REMARK 465 ASP A 144 REMARK 465 TYR A 145 REMARK 465 PHE A 146 REMARK 465 PRO A 147 REMARK 465 GLU A 148 REMARK 465 PRO A 149 REMARK 465 VAL A 150 REMARK 465 THR A 151 REMARK 465 VAL A 152 REMARK 465 SER A 153 REMARK 465 TRP A 154 REMARK 465 ASN A 155 REMARK 465 SER A 156 REMARK 465 GLY A 157 REMARK 465 ALA A 158 REMARK 465 LEU A 159 REMARK 465 THR A 160 REMARK 465 SER A 161 REMARK 465 GLY A 162 REMARK 465 VAL A 163 REMARK 465 HIS A 164 REMARK 465 THR A 165 REMARK 465 PHE A 166 REMARK 465 PRO A 167 REMARK 465 ALA A 168 REMARK 465 VAL A 169 REMARK 465 LEU A 170 REMARK 465 GLN A 171 REMARK 465 SER A 172 REMARK 465 SER A 173 REMARK 465 GLY A 174 REMARK 465 LEU A 175 REMARK 465 TYR A 176 REMARK 465 SER A 177 REMARK 465 LEU A 178 REMARK 465 SER A 179 REMARK 465 SER A 180 REMARK 465 VAL A 181 REMARK 465 VAL A 182 REMARK 465 THR A 183 REMARK 465 VAL A 184 REMARK 465 PRO A 185 REMARK 465 SER A 186 REMARK 465 SER A 187 REMARK 465 SER A 188 REMARK 465 LEU A 189 REMARK 465 GLY A 190 REMARK 465 THR A 191 REMARK 465 GLN A 192 REMARK 465 THR A 193 REMARK 465 TYR A 194 REMARK 465 ILE A 195 REMARK 465 CYS A 196 REMARK 465 ASN A 197 REMARK 465 VAL A 198 REMARK 465 ASN A 199 REMARK 465 HIS A 200 REMARK 465 LYS A 201 REMARK 465 PRO A 202 REMARK 465 SER A 203 REMARK 465 ASN A 204 REMARK 465 THR A 205 REMARK 465 LYS A 206 REMARK 465 VAL A 207 REMARK 465 ASP A 208 REMARK 465 LYS A 209 REMARK 465 LYS A 210 REMARK 465 VAL A 211 REMARK 465 SER B 112 REMARK 465 SER B 113 REMARK 465 ALA B 114 REMARK 465 SER B 115 REMARK 465 THR B 116 REMARK 465 LYS B 117 REMARK 465 GLY B 118 REMARK 465 PRO B 119 REMARK 465 SER B 120 REMARK 465 VAL B 121 REMARK 465 PHE B 122 REMARK 465 PRO B 123 REMARK 465 LEU B 124 REMARK 465 ALA B 125 REMARK 465 PRO B 126 REMARK 465 SER B 127 REMARK 465 SER B 128 REMARK 465 LYS B 129 REMARK 465 SER B 130 REMARK 465 THR B 131 REMARK 465 SER B 132 REMARK 465 GLY B 133 REMARK 465 GLY B 134 REMARK 465 THR B 135 REMARK 465 ALA B 136 REMARK 465 ALA B 137 REMARK 465 LEU B 138 REMARK 465 GLY B 139 REMARK 465 CYS B 140 REMARK 465 LEU B 141 REMARK 465 VAL B 142 REMARK 465 LYS B 143 REMARK 465 ASP B 144 REMARK 465 TYR B 145 REMARK 465 PHE B 146 REMARK 465 PRO B 147 REMARK 465 GLU B 148 REMARK 465 PRO B 149 REMARK 465 VAL B 150 REMARK 465 THR B 151 REMARK 465 VAL B 152 REMARK 465 SER B 153 REMARK 465 TRP B 154 REMARK 465 ASN B 155 REMARK 465 SER B 156 REMARK 465 GLY B 157 REMARK 465 ALA B 158 REMARK 465 LEU B 159 REMARK 465 THR B 160 REMARK 465 SER B 161 REMARK 465 GLY B 162 REMARK 465 VAL B 163 REMARK 465 HIS B 164 REMARK 465 THR B 165 REMARK 465 PHE B 166 REMARK 465 PRO B 167 REMARK 465 ALA B 168 REMARK 465 VAL B 169 REMARK 465 LEU B 170 REMARK 465 GLN B 171 REMARK 465 SER B 172 REMARK 465 SER B 173 REMARK 465 GLY B 174 REMARK 465 LEU B 175 REMARK 465 TYR B 176 REMARK 465 SER B 177 REMARK 465 LEU B 178 REMARK 465 SER B 179 REMARK 465 SER B 180 REMARK 465 VAL B 181 REMARK 465 VAL B 182 REMARK 465 THR B 183 REMARK 465 VAL B 184 REMARK 465 PRO B 185 REMARK 465 SER B 186 REMARK 465 SER B 187 REMARK 465 SER B 188 REMARK 465 LEU B 189 REMARK 465 GLY B 190 REMARK 465 THR B 191 REMARK 465 GLN B 192 REMARK 465 THR B 193 REMARK 465 TYR B 194 REMARK 465 ILE B 195 REMARK 465 CYS B 196 REMARK 465 ASN B 197 REMARK 465 VAL B 198 REMARK 465 ASN B 199 REMARK 465 HIS B 200 REMARK 465 LYS B 201 REMARK 465 PRO B 202 REMARK 465 SER B 203 REMARK 465 ASN B 204 REMARK 465 THR B 205 REMARK 465 LYS B 206 REMARK 465 VAL B 207 REMARK 465 ASP B 208 REMARK 465 LYS B 209 REMARK 465 LYS B 210 REMARK 465 VAL B 211 REMARK 465 SER C 112 REMARK 465 SER C 113 REMARK 465 ALA C 114 REMARK 465 SER C 115 REMARK 465 THR C 116 REMARK 465 LYS C 117 REMARK 465 GLY C 118 REMARK 465 PRO C 119 REMARK 465 SER C 120 REMARK 465 VAL C 121 REMARK 465 PHE C 122 REMARK 465 PRO C 123 REMARK 465 LEU C 124 REMARK 465 ALA C 125 REMARK 465 PRO C 126 REMARK 465 SER C 127 REMARK 465 SER C 128 REMARK 465 LYS C 129 REMARK 465 SER C 130 REMARK 465 THR C 131 REMARK 465 SER C 132 REMARK 465 GLY C 133 REMARK 465 GLY C 134 REMARK 465 THR C 135 REMARK 465 ALA C 136 REMARK 465 ALA C 137 REMARK 465 LEU C 138 REMARK 465 GLY C 139 REMARK 465 CYS C 140 REMARK 465 LEU C 141 REMARK 465 VAL C 142 REMARK 465 LYS C 143 REMARK 465 ASP C 144 REMARK 465 TYR C 145 REMARK 465 PHE C 146 REMARK 465 PRO C 147 REMARK 465 GLU C 148 REMARK 465 PRO C 149 REMARK 465 VAL C 150 REMARK 465 THR C 151 REMARK 465 VAL C 152 REMARK 465 SER C 153 REMARK 465 TRP C 154 REMARK 465 ASN C 155 REMARK 465 SER C 156 REMARK 465 GLY C 157 REMARK 465 ALA C 158 REMARK 465 LEU C 159 REMARK 465 THR C 160 REMARK 465 SER C 161 REMARK 465 GLY C 162 REMARK 465 VAL C 163 REMARK 465 HIS C 164 REMARK 465 THR C 165 REMARK 465 PHE C 166 REMARK 465 PRO C 167 REMARK 465 ALA C 168 REMARK 465 VAL C 169 REMARK 465 LEU C 170 REMARK 465 GLN C 171 REMARK 465 SER C 172 REMARK 465 SER C 173 REMARK 465 GLY C 174 REMARK 465 LEU C 175 REMARK 465 TYR C 176 REMARK 465 SER C 177 REMARK 465 LEU C 178 REMARK 465 SER C 179 REMARK 465 SER C 180 REMARK 465 VAL C 181 REMARK 465 VAL C 182 REMARK 465 THR C 183 REMARK 465 VAL C 184 REMARK 465 PRO C 185 REMARK 465 SER C 186 REMARK 465 SER C 187 REMARK 465 SER C 188 REMARK 465 LEU C 189 REMARK 465 GLY C 190 REMARK 465 THR C 191 REMARK 465 GLN C 192 REMARK 465 THR C 193 REMARK 465 TYR C 194 REMARK 465 ILE C 195 REMARK 465 CYS C 196 REMARK 465 ASN C 197 REMARK 465 VAL C 198 REMARK 465 ASN C 199 REMARK 465 HIS C 200 REMARK 465 LYS C 201 REMARK 465 PRO C 202 REMARK 465 SER C 203 REMARK 465 ASN C 204 REMARK 465 THR C 205 REMARK 465 LYS C 206 REMARK 465 VAL C 207 REMARK 465 ASP C 208 REMARK 465 LYS C 209 REMARK 465 LYS C 210 REMARK 465 VAL C 211 REMARK 465 THR D 109 REMARK 465 VAL D 110 REMARK 465 ALA D 111 REMARK 465 ALA D 112 REMARK 465 PRO D 113 REMARK 465 SER D 114 REMARK 465 VAL D 115 REMARK 465 PHE D 116 REMARK 465 ILE D 117 REMARK 465 PHE D 118 REMARK 465 PRO D 119 REMARK 465 PRO D 120 REMARK 465 SER D 121 REMARK 465 ASP D 122 REMARK 465 GLU D 123 REMARK 465 GLN D 124 REMARK 465 LEU D 125 REMARK 465 LYS D 126 REMARK 465 SER D 127 REMARK 465 GLY D 128 REMARK 465 THR D 129 REMARK 465 ALA D 130 REMARK 465 SER D 131 REMARK 465 VAL D 132 REMARK 465 VAL D 133 REMARK 465 CYS D 134 REMARK 465 LEU D 135 REMARK 465 LEU D 136 REMARK 465 ASN D 137 REMARK 465 ASN D 138 REMARK 465 PHE D 139 REMARK 465 TYR D 140 REMARK 465 PRO D 141 REMARK 465 ARG D 142 REMARK 465 GLU D 143 REMARK 465 ALA D 144 REMARK 465 LYS D 145 REMARK 465 VAL D 146 REMARK 465 GLN D 147 REMARK 465 TRP D 148 REMARK 465 LYS D 149 REMARK 465 VAL D 150 REMARK 465 ASP D 151 REMARK 465 ASN D 152 REMARK 465 ALA D 153 REMARK 465 LEU D 154 REMARK 465 GLN D 155 REMARK 465 SER D 156 REMARK 465 GLY D 157 REMARK 465 ASN D 158 REMARK 465 SER D 159 REMARK 465 GLN D 160 REMARK 465 GLU D 161 REMARK 465 SER D 162 REMARK 465 VAL D 163 REMARK 465 THR D 164 REMARK 465 GLU D 165 REMARK 465 GLN D 166 REMARK 465 ASP D 167 REMARK 465 SER D 168 REMARK 465 LYS D 169 REMARK 465 ASP D 170 REMARK 465 SER D 171 REMARK 465 THR D 172 REMARK 465 TYR D 173 REMARK 465 SER D 174 REMARK 465 LEU D 175 REMARK 465 SER D 176 REMARK 465 SER D 177 REMARK 465 THR D 178 REMARK 465 LEU D 179 REMARK 465 THR D 180 REMARK 465 LEU D 181 REMARK 465 SER D 182 REMARK 465 LYS D 183 REMARK 465 ALA D 184 REMARK 465 ASP D 185 REMARK 465 TYR D 186 REMARK 465 GLU D 187 REMARK 465 LYS D 188 REMARK 465 HIS D 189 REMARK 465 LYS D 190 REMARK 465 VAL D 191 REMARK 465 TYR D 192 REMARK 465 ALA D 193 REMARK 465 CYS D 194 REMARK 465 GLU D 195 REMARK 465 VAL D 196 REMARK 465 THR D 197 REMARK 465 HIS D 198 REMARK 465 GLN D 199 REMARK 465 GLY D 200 REMARK 465 LEU D 201 REMARK 465 SER D 202 REMARK 465 SER D 203 REMARK 465 PRO D 204 REMARK 465 VAL D 205 REMARK 465 THR D 206 REMARK 465 LYS D 207 REMARK 465 SER D 208 REMARK 465 PHE D 209 REMARK 465 ASN D 210 REMARK 465 ARG D 211 REMARK 465 GLY D 212 REMARK 465 GLU D 213 REMARK 465 CYS D 214 REMARK 465 THR E 109 REMARK 465 VAL E 110 REMARK 465 ALA E 111 REMARK 465 ALA E 112 REMARK 465 PRO E 113 REMARK 465 SER E 114 REMARK 465 VAL E 115 REMARK 465 PHE E 116 REMARK 465 ILE E 117 REMARK 465 PHE E 118 REMARK 465 PRO E 119 REMARK 465 PRO E 120 REMARK 465 SER E 121 REMARK 465 ASP E 122 REMARK 465 GLU E 123 REMARK 465 GLN E 124 REMARK 465 LEU E 125 REMARK 465 LYS E 126 REMARK 465 SER E 127 REMARK 465 GLY E 128 REMARK 465 THR E 129 REMARK 465 ALA E 130 REMARK 465 SER E 131 REMARK 465 VAL E 132 REMARK 465 VAL E 133 REMARK 465 CYS E 134 REMARK 465 LEU E 135 REMARK 465 LEU E 136 REMARK 465 ASN E 137 REMARK 465 ASN E 138 REMARK 465 PHE E 139 REMARK 465 TYR E 140 REMARK 465 PRO E 141 REMARK 465 ARG E 142 REMARK 465 GLU E 143 REMARK 465 ALA E 144 REMARK 465 LYS E 145 REMARK 465 VAL E 146 REMARK 465 GLN E 147 REMARK 465 TRP E 148 REMARK 465 LYS E 149 REMARK 465 VAL E 150 REMARK 465 ASP E 151 REMARK 465 ASN E 152 REMARK 465 ALA E 153 REMARK 465 LEU E 154 REMARK 465 GLN E 155 REMARK 465 SER E 156 REMARK 465 GLY E 157 REMARK 465 ASN E 158 REMARK 465 SER E 159 REMARK 465 GLN E 160 REMARK 465 GLU E 161 REMARK 465 SER E 162 REMARK 465 VAL E 163 REMARK 465 THR E 164 REMARK 465 GLU E 165 REMARK 465 GLN E 166 REMARK 465 ASP E 167 REMARK 465 SER E 168 REMARK 465 LYS E 169 REMARK 465 ASP E 170 REMARK 465 SER E 171 REMARK 465 THR E 172 REMARK 465 TYR E 173 REMARK 465 SER E 174 REMARK 465 LEU E 175 REMARK 465 SER E 176 REMARK 465 SER E 177 REMARK 465 THR E 178 REMARK 465 LEU E 179 REMARK 465 THR E 180 REMARK 465 LEU E 181 REMARK 465 SER E 182 REMARK 465 LYS E 183 REMARK 465 ALA E 184 REMARK 465 ASP E 185 REMARK 465 TYR E 186 REMARK 465 GLU E 187 REMARK 465 LYS E 188 REMARK 465 HIS E 189 REMARK 465 LYS E 190 REMARK 465 VAL E 191 REMARK 465 TYR E 192 REMARK 465 ALA E 193 REMARK 465 CYS E 194 REMARK 465 GLU E 195 REMARK 465 VAL E 196 REMARK 465 THR E 197 REMARK 465 HIS E 198 REMARK 465 GLN E 199 REMARK 465 GLY E 200 REMARK 465 LEU E 201 REMARK 465 SER E 202 REMARK 465 SER E 203 REMARK 465 PRO E 204 REMARK 465 VAL E 205 REMARK 465 THR E 206 REMARK 465 LYS E 207 REMARK 465 SER E 208 REMARK 465 PHE E 209 REMARK 465 ASN E 210 REMARK 465 ARG E 211 REMARK 465 GLY E 212 REMARK 465 GLU E 213 REMARK 465 CYS E 214 REMARK 465 THR F 109 REMARK 465 VAL F 110 REMARK 465 ALA F 111 REMARK 465 ALA F 112 REMARK 465 PRO F 113 REMARK 465 SER F 114 REMARK 465 VAL F 115 REMARK 465 PHE F 116 REMARK 465 ILE F 117 REMARK 465 PHE F 118 REMARK 465 PRO F 119 REMARK 465 PRO F 120 REMARK 465 SER F 121 REMARK 465 ASP F 122 REMARK 465 GLU F 123 REMARK 465 GLN F 124 REMARK 465 LEU F 125 REMARK 465 LYS F 126 REMARK 465 SER F 127 REMARK 465 GLY F 128 REMARK 465 THR F 129 REMARK 465 ALA F 130 REMARK 465 SER F 131 REMARK 465 VAL F 132 REMARK 465 VAL F 133 REMARK 465 CYS F 134 REMARK 465 LEU F 135 REMARK 465 LEU F 136 REMARK 465 ASN F 137 REMARK 465 ASN F 138 REMARK 465 PHE F 139 REMARK 465 TYR F 140 REMARK 465 PRO F 141 REMARK 465 ARG F 142 REMARK 465 GLU F 143 REMARK 465 ALA F 144 REMARK 465 LYS F 145 REMARK 465 VAL F 146 REMARK 465 GLN F 147 REMARK 465 TRP F 148 REMARK 465 LYS F 149 REMARK 465 VAL F 150 REMARK 465 ASP F 151 REMARK 465 ASN F 152 REMARK 465 ALA F 153 REMARK 465 LEU F 154 REMARK 465 GLN F 155 REMARK 465 SER F 156 REMARK 465 GLY F 157 REMARK 465 ASN F 158 REMARK 465 SER F 159 REMARK 465 GLN F 160 REMARK 465 GLU F 161 REMARK 465 SER F 162 REMARK 465 VAL F 163 REMARK 465 THR F 164 REMARK 465 GLU F 165 REMARK 465 GLN F 166 REMARK 465 ASP F 167 REMARK 465 SER F 168 REMARK 465 LYS F 169 REMARK 465 ASP F 170 REMARK 465 SER F 171 REMARK 465 THR F 172 REMARK 465 TYR F 173 REMARK 465 SER F 174 REMARK 465 LEU F 175 REMARK 465 SER F 176 REMARK 465 SER F 177 REMARK 465 THR F 178 REMARK 465 LEU F 179 REMARK 465 THR F 180 REMARK 465 LEU F 181 REMARK 465 SER F 182 REMARK 465 LYS F 183 REMARK 465 ALA F 184 REMARK 465 ASP F 185 REMARK 465 TYR F 186 REMARK 465 GLU F 187 REMARK 465 LYS F 188 REMARK 465 HIS F 189 REMARK 465 LYS F 190 REMARK 465 VAL F 191 REMARK 465 TYR F 192 REMARK 465 ALA F 193 REMARK 465 CYS F 194 REMARK 465 GLU F 195 REMARK 465 VAL F 196 REMARK 465 THR F 197 REMARK 465 HIS F 198 REMARK 465 GLN F 199 REMARK 465 GLY F 200 REMARK 465 LEU F 201 REMARK 465 SER F 202 REMARK 465 SER F 203 REMARK 465 PRO F 204 REMARK 465 VAL F 205 REMARK 465 THR F 206 REMARK 465 LYS F 207 REMARK 465 SER F 208 REMARK 465 PHE F 209 REMARK 465 ASN F 210 REMARK 465 ARG F 211 REMARK 465 GLY F 212 REMARK 465 GLU F 213 REMARK 465 CYS F 214 REMARK 465 MET G 1 REMARK 465 SER G 2 REMARK 465 TRP G 3 REMARK 465 LYS G 4 REMARK 465 VAL G 5 REMARK 465 VAL G 6 REMARK 465 ILE G 7 REMARK 465 ILE G 8 REMARK 465 PHE G 9 REMARK 465 SER G 10 REMARK 465 LEU G 11 REMARK 465 LEU G 12 REMARK 465 ILE G 13 REMARK 465 THR G 14 REMARK 465 PRO G 15 REMARK 465 GLN G 16 REMARK 465 HIS G 17 REMARK 465 GLY G 18 REMARK 465 ALA G 86 REMARK 465 ASP G 87 REMARK 465 GLN G 88 REMARK 465 LEU G 89 REMARK 465 ALA G 90 REMARK 465 ARG G 91 REMARK 465 GLU G 92 REMARK 465 GLU G 93 REMARK 465 GLN G 94 REMARK 465 ILE G 95 REMARK 465 GLU G 96 REMARK 465 ASN G 97 REMARK 465 PRO G 98 REMARK 465 ARG G 99 REMARK 465 ARG G 100 REMARK 465 ARG G 101 REMARK 465 ARG G 102 REMARK 465 GLU G 465 REMARK 465 SER G 466 REMARK 465 ILE G 467 REMARK 465 GLU G 468 REMARK 465 ASN G 469 REMARK 465 SER G 470 REMARK 465 GLN G 471 REMARK 465 ALA G 472 REMARK 465 LEU G 473 REMARK 465 VAL G 474 REMARK 465 ASP G 475 REMARK 465 GLN G 476 REMARK 465 SER G 477 REMARK 465 ASN G 478 REMARK 465 ARG G 479 REMARK 465 ILE G 480 REMARK 465 LEU G 481 REMARK 465 SER G 482 REMARK 465 SER G 483 REMARK 465 ALA G 484 REMARK 465 GLU G 485 REMARK 465 LYS G 486 REMARK 465 GLY G 487 REMARK 465 ASN G 488 REMARK 465 THR G 489 REMARK 465 GLY G 490 REMARK 465 GLY G 491 REMARK 465 GLY G 492 REMARK 465 GLY G 493 REMARK 465 SER G 494 REMARK 465 GLY G 495 REMARK 465 TYR G 496 REMARK 465 ILE G 497 REMARK 465 PRO G 498 REMARK 465 GLU G 499 REMARK 465 ALA G 500 REMARK 465 PRO G 501 REMARK 465 ARG G 502 REMARK 465 ASP G 503 REMARK 465 GLY G 504 REMARK 465 GLN G 505 REMARK 465 ALA G 506 REMARK 465 TYR G 507 REMARK 465 VAL G 508 REMARK 465 ARG G 509 REMARK 465 LYS G 510 REMARK 465 ASP G 511 REMARK 465 GLY G 512 REMARK 465 GLU G 513 REMARK 465 TRP G 514 REMARK 465 VAL G 515 REMARK 465 LEU G 516 REMARK 465 LEU G 517 REMARK 465 SER G 518 REMARK 465 THR G 519 REMARK 465 PHE G 520 REMARK 465 LEU G 521 REMARK 465 GLY G 522 REMARK 465 ARG G 523 REMARK 465 SER G 524 REMARK 465 LEU G 525 REMARK 465 GLU G 526 REMARK 465 VAL G 527 REMARK 465 LEU G 528 REMARK 465 PHE G 529 REMARK 465 GLN G 530 REMARK 465 GLY G 531 REMARK 465 PRO G 532 REMARK 465 GLY G 533 REMARK 465 HIS G 534 REMARK 465 HIS G 535 REMARK 465 HIS G 536 REMARK 465 HIS G 537 REMARK 465 HIS G 538 REMARK 465 HIS G 539 REMARK 465 HIS G 540 REMARK 465 HIS G 541 REMARK 465 SER G 542 REMARK 465 ALA G 543 REMARK 465 TRP G 544 REMARK 465 SER G 545 REMARK 465 HIS G 546 REMARK 465 PRO G 547 REMARK 465 GLN G 548 REMARK 465 PHE G 549 REMARK 465 GLU G 550 REMARK 465 LYS G 551 REMARK 465 MET H 1 REMARK 465 SER H 2 REMARK 465 TRP H 3 REMARK 465 LYS H 4 REMARK 465 VAL H 5 REMARK 465 VAL H 6 REMARK 465 ILE H 7 REMARK 465 ILE H 8 REMARK 465 PHE H 9 REMARK 465 SER H 10 REMARK 465 LEU H 11 REMARK 465 LEU H 12 REMARK 465 ILE H 13 REMARK 465 THR H 14 REMARK 465 PRO H 15 REMARK 465 GLN H 16 REMARK 465 HIS H 17 REMARK 465 GLY H 18 REMARK 465 ALA H 86 REMARK 465 ASP H 87 REMARK 465 GLN H 88 REMARK 465 LEU H 89 REMARK 465 ALA H 90 REMARK 465 ARG H 91 REMARK 465 GLU H 92 REMARK 465 GLU H 93 REMARK 465 GLN H 94 REMARK 465 ILE H 95 REMARK 465 GLU H 96 REMARK 465 ASN H 97 REMARK 465 PRO H 98 REMARK 465 ARG H 99 REMARK 465 ARG H 100 REMARK 465 ARG H 101 REMARK 465 ARG H 102 REMARK 465 GLU H 465 REMARK 465 SER H 466 REMARK 465 ILE H 467 REMARK 465 GLU H 468 REMARK 465 ASN H 469 REMARK 465 SER H 470 REMARK 465 GLN H 471 REMARK 465 ALA H 472 REMARK 465 LEU H 473 REMARK 465 VAL H 474 REMARK 465 ASP H 475 REMARK 465 GLN H 476 REMARK 465 SER H 477 REMARK 465 ASN H 478 REMARK 465 ARG H 479 REMARK 465 ILE H 480 REMARK 465 LEU H 481 REMARK 465 SER H 482 REMARK 465 SER H 483 REMARK 465 ALA H 484 REMARK 465 GLU H 485 REMARK 465 LYS H 486 REMARK 465 GLY H 487 REMARK 465 ASN H 488 REMARK 465 THR H 489 REMARK 465 GLY H 490 REMARK 465 GLY H 491 REMARK 465 GLY H 492 REMARK 465 GLY H 493 REMARK 465 SER H 494 REMARK 465 GLY H 495 REMARK 465 TYR H 496 REMARK 465 ILE H 497 REMARK 465 PRO H 498 REMARK 465 GLU H 499 REMARK 465 ALA H 500 REMARK 465 PRO H 501 REMARK 465 ARG H 502 REMARK 465 ASP H 503 REMARK 465 GLY H 504 REMARK 465 GLN H 505 REMARK 465 ALA H 506 REMARK 465 TYR H 507 REMARK 465 VAL H 508 REMARK 465 ARG H 509 REMARK 465 LYS H 510 REMARK 465 ASP H 511 REMARK 465 GLY H 512 REMARK 465 GLU H 513 REMARK 465 TRP H 514 REMARK 465 VAL H 515 REMARK 465 LEU H 516 REMARK 465 LEU H 517 REMARK 465 SER H 518 REMARK 465 THR H 519 REMARK 465 PHE H 520 REMARK 465 LEU H 521 REMARK 465 GLY H 522 REMARK 465 ARG H 523 REMARK 465 SER H 524 REMARK 465 LEU H 525 REMARK 465 GLU H 526 REMARK 465 VAL H 527 REMARK 465 LEU H 528 REMARK 465 PHE H 529 REMARK 465 GLN H 530 REMARK 465 GLY H 531 REMARK 465 PRO H 532 REMARK 465 GLY H 533 REMARK 465 HIS H 534 REMARK 465 HIS H 535 REMARK 465 HIS H 536 REMARK 465 HIS H 537 REMARK 465 HIS H 538 REMARK 465 HIS H 539 REMARK 465 HIS H 540 REMARK 465 HIS H 541 REMARK 465 SER H 542 REMARK 465 ALA H 543 REMARK 465 TRP H 544 REMARK 465 SER H 545 REMARK 465 HIS H 546 REMARK 465 PRO H 547 REMARK 465 GLN H 548 REMARK 465 PHE H 549 REMARK 465 GLU H 550 REMARK 465 LYS H 551 REMARK 465 MET I 1 REMARK 465 SER I 2 REMARK 465 TRP I 3 REMARK 465 LYS I 4 REMARK 465 VAL I 5 REMARK 465 VAL I 6 REMARK 465 ILE I 7 REMARK 465 ILE I 8 REMARK 465 PHE I 9 REMARK 465 SER I 10 REMARK 465 LEU I 11 REMARK 465 LEU I 12 REMARK 465 ILE I 13 REMARK 465 THR I 14 REMARK 465 PRO I 15 REMARK 465 GLN I 16 REMARK 465 HIS I 17 REMARK 465 GLY I 18 REMARK 465 ALA I 86 REMARK 465 ASP I 87 REMARK 465 GLN I 88 REMARK 465 LEU I 89 REMARK 465 ALA I 90 REMARK 465 ARG I 91 REMARK 465 GLU I 92 REMARK 465 GLU I 93 REMARK 465 GLN I 94 REMARK 465 ILE I 95 REMARK 465 GLU I 96 REMARK 465 ASN I 97 REMARK 465 PRO I 98 REMARK 465 ARG I 99 REMARK 465 ARG I 100 REMARK 465 ARG I 101 REMARK 465 ARG I 102 REMARK 465 GLU I 465 REMARK 465 SER I 466 REMARK 465 ILE I 467 REMARK 465 GLU I 468 REMARK 465 ASN I 469 REMARK 465 SER I 470 REMARK 465 GLN I 471 REMARK 465 ALA I 472 REMARK 465 LEU I 473 REMARK 465 VAL I 474 REMARK 465 ASP I 475 REMARK 465 GLN I 476 REMARK 465 SER I 477 REMARK 465 ASN I 478 REMARK 465 ARG I 479 REMARK 465 ILE I 480 REMARK 465 LEU I 481 REMARK 465 SER I 482 REMARK 465 SER I 483 REMARK 465 ALA I 484 REMARK 465 GLU I 485 REMARK 465 LYS I 486 REMARK 465 GLY I 487 REMARK 465 ASN I 488 REMARK 465 THR I 489 REMARK 465 GLY I 490 REMARK 465 GLY I 491 REMARK 465 GLY I 492 REMARK 465 GLY I 493 REMARK 465 SER I 494 REMARK 465 GLY I 495 REMARK 465 TYR I 496 REMARK 465 ILE I 497 REMARK 465 PRO I 498 REMARK 465 GLU I 499 REMARK 465 ALA I 500 REMARK 465 PRO I 501 REMARK 465 ARG I 502 REMARK 465 ASP I 503 REMARK 465 GLY I 504 REMARK 465 GLN I 505 REMARK 465 ALA I 506 REMARK 465 TYR I 507 REMARK 465 VAL I 508 REMARK 465 ARG I 509 REMARK 465 LYS I 510 REMARK 465 ASP I 511 REMARK 465 GLY I 512 REMARK 465 GLU I 513 REMARK 465 TRP I 514 REMARK 465 VAL I 515 REMARK 465 LEU I 516 REMARK 465 LEU I 517 REMARK 465 SER I 518 REMARK 465 THR I 519 REMARK 465 PHE I 520 REMARK 465 LEU I 521 REMARK 465 GLY I 522 REMARK 465 ARG I 523 REMARK 465 SER I 524 REMARK 465 LEU I 525 REMARK 465 GLU I 526 REMARK 465 VAL I 527 REMARK 465 LEU I 528 REMARK 465 PHE I 529 REMARK 465 GLN I 530 REMARK 465 GLY I 531 REMARK 465 PRO I 532 REMARK 465 GLY I 533 REMARK 465 HIS I 534 REMARK 465 HIS I 535 REMARK 465 HIS I 536 REMARK 465 HIS I 537 REMARK 465 HIS I 538 REMARK 465 HIS I 539 REMARK 465 HIS I 540 REMARK 465 HIS I 541 REMARK 465 SER I 542 REMARK 465 ALA I 543 REMARK 465 TRP I 544 REMARK 465 SER I 545 REMARK 465 HIS I 546 REMARK 465 PRO I 547 REMARK 465 GLN I 548 REMARK 465 PHE I 549 REMARK 465 GLU I 550 REMARK 465 LYS I 551 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 CYS A 98 -154.79 -140.71 REMARK 500 CYS B 98 -156.29 -141.35 REMARK 500 CYS C 98 -155.69 -140.63 REMARK 500 ASP D 30 -115.05 52.47 REMARK 500 ALA D 51 -30.20 59.57 REMARK 500 SER D 52 -5.79 -140.06 REMARK 500 ASP E 30 -114.63 53.21 REMARK 500 ALA E 51 -30.95 59.25 REMARK 500 ASP F 30 -115.30 52.97 REMARK 500 ALA F 51 -30.04 59.73 REMARK 500 SER F 52 -6.22 -140.29 REMARK 500 PHE G 168 -70.94 -38.87 REMARK 500 ASN G 172 -92.63 -139.93 REMARK 500 ASP G 306 38.30 -72.66 REMARK 500 ASN G 353 56.57 -145.40 REMARK 500 ARG G 367 9.16 -64.29 REMARK 500 TYR G 385 -164.44 -119.11 REMARK 500 ASP G 421 -113.48 50.50 REMARK 500 VAL G 458 -155.58 -120.85 REMARK 500 SER H 27 30.78 -145.50 REMARK 500 CYS H 28 51.62 37.29 REMARK 500 VAL H 104 106.56 -55.68 REMARK 500 PHE H 168 -70.61 -39.10 REMARK 500 ASN H 172 -89.12 -140.56 REMARK 500 ASN H 180 19.46 59.63 REMARK 500 ASP H 306 42.36 -83.98 REMARK 500 ASN H 353 57.90 -146.49 REMARK 500 TYR H 385 -166.27 -118.37 REMARK 500 ASP H 421 -111.65 50.60 REMARK 500 ALA H 459 -146.77 50.28 REMARK 500 ASN I 172 -69.05 -133.39 REMARK 500 ASN I 180 19.04 59.87 REMARK 500 TYR I 299 31.75 -84.91 REMARK 500 ASP I 306 40.03 -76.20 REMARK 500 ASN I 353 54.66 -146.17 REMARK 500 ASP I 421 -113.45 50.83 REMARK 500 PRO I 448 48.96 -78.45 REMARK 500 VAL I 449 47.88 39.55 REMARK 500 PHE I 451 70.28 34.29 REMARK 500 ASP I 454 43.28 34.13 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG D 103 0.07 SIDE CHAIN REMARK 500 ARG E 103 0.09 SIDE CHAIN REMARK 500 ARG F 24 0.08 SIDE CHAIN REMARK 500 ARG F 103 0.08 SIDE CHAIN REMARK 500 ARG H 253 0.07 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-45412 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF THE HUMAN NEUTRALIZING ANTIBODY 5-1 IN COMPLEX REMARK 900 WITH PREFUSION HUMAN METAPNEUMOVIRUS F GLYCOPROTEIN DBREF 9CB1 A 1 211 PDB 9CB1 9CB1 1 211 DBREF 9CB1 B 1 211 PDB 9CB1 9CB1 1 211 DBREF 9CB1 C 1 211 PDB 9CB1 9CB1 1 211 DBREF 9CB1 D 1 214 PDB 9CB1 9CB1 1 214 DBREF 9CB1 E 1 214 PDB 9CB1 9CB1 1 214 DBREF 9CB1 F 1 214 PDB 9CB1 9CB1 1 214 DBREF 9CB1 G 1 490 UNP H6X1Z1 H6X1Z1_9MONO 1 490 DBREF 9CB1 H 1 490 UNP H6X1Z1 H6X1Z1_9MONO 1 490 DBREF 9CB1 I 1 490 UNP H6X1Z1 H6X1Z1_9MONO 1 490 SEQADV 9CB1 CYS G 84 UNP H6X1Z1 VAL 84 ENGINEERED MUTATION SEQADV 9CB1 ARG G 100 UNP H6X1Z1 GLN 100 ENGINEERED MUTATION SEQADV 9CB1 ARG G 101 UNP H6X1Z1 SER 101 ENGINEERED MUTATION SEQADV 9CB1 CYS G 110 UNP H6X1Z1 LEU 110 ENGINEERED MUTATION SEQADV 9CB1 CYS G 127 UNP H6X1Z1 THR 127 ENGINEERED MUTATION SEQADV 9CB1 CYS G 140 UNP H6X1Z1 ALA 140 ENGINEERED MUTATION SEQADV 9CB1 CYS G 147 UNP H6X1Z1 ALA 147 ENGINEERED MUTATION SEQADV 9CB1 CYS G 153 UNP H6X1Z1 ASN 153 ENGINEERED MUTATION SEQADV 9CB1 PRO G 185 UNP H6X1Z1 ALA 185 ENGINEERED MUTATION SEQADV 9CB1 LYS G 219 UNP H6X1Z1 LEU 219 ENGINEERED MUTATION SEQADV 9CB1 ILE G 231 UNP H6X1Z1 VAL 231 ENGINEERED MUTATION SEQADV 9CB1 CYS G 249 UNP H6X1Z1 ALA 249 ENGINEERED MUTATION SEQADV 9CB1 CYS G 322 UNP H6X1Z1 ASN 322 ENGINEERED MUTATION SEQADV 9CB1 CYS G 365 UNP H6X1Z1 THR 365 ENGINEERED MUTATION SEQADV 9CB1 GLN G 453 UNP H6X1Z1 GLU 453 ENGINEERED MUTATION SEQADV 9CB1 CYS G 463 UNP H6X1Z1 VAL 463 ENGINEERED MUTATION SEQADV 9CB1 GLY G 491 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 492 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 493 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER G 494 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 495 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TYR G 496 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ILE G 497 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO G 498 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU G 499 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA G 500 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO G 501 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG G 502 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ASP G 503 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 504 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN G 505 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA G 506 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TYR G 507 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL G 508 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG G 509 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LYS G 510 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ASP G 511 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 512 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU G 513 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TRP G 514 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL G 515 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU G 516 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU G 517 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER G 518 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 THR G 519 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE G 520 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU G 521 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 522 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG G 523 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER G 524 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU G 525 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU G 526 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL G 527 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU G 528 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE G 529 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN G 530 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 531 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO G 532 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY G 533 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 534 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 535 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 536 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 537 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 538 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 539 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 540 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 541 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER G 542 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA G 543 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TRP G 544 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER G 545 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS G 546 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO G 547 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN G 548 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE G 549 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU G 550 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LYS G 551 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 CYS H 84 UNP H6X1Z1 VAL 84 ENGINEERED MUTATION SEQADV 9CB1 ARG H 100 UNP H6X1Z1 GLN 100 ENGINEERED MUTATION SEQADV 9CB1 ARG H 101 UNP H6X1Z1 SER 101 ENGINEERED MUTATION SEQADV 9CB1 CYS H 110 UNP H6X1Z1 LEU 110 ENGINEERED MUTATION SEQADV 9CB1 CYS H 127 UNP H6X1Z1 THR 127 ENGINEERED MUTATION SEQADV 9CB1 CYS H 140 UNP H6X1Z1 ALA 140 ENGINEERED MUTATION SEQADV 9CB1 CYS H 147 UNP H6X1Z1 ALA 147 ENGINEERED MUTATION SEQADV 9CB1 CYS H 153 UNP H6X1Z1 ASN 153 ENGINEERED MUTATION SEQADV 9CB1 PRO H 185 UNP H6X1Z1 ALA 185 ENGINEERED MUTATION SEQADV 9CB1 LYS H 219 UNP H6X1Z1 LEU 219 ENGINEERED MUTATION SEQADV 9CB1 ILE H 231 UNP H6X1Z1 VAL 231 ENGINEERED MUTATION SEQADV 9CB1 CYS H 249 UNP H6X1Z1 ALA 249 ENGINEERED MUTATION SEQADV 9CB1 CYS H 322 UNP H6X1Z1 ASN 322 ENGINEERED MUTATION SEQADV 9CB1 CYS H 365 UNP H6X1Z1 THR 365 ENGINEERED MUTATION SEQADV 9CB1 GLN H 453 UNP H6X1Z1 GLU 453 ENGINEERED MUTATION SEQADV 9CB1 CYS H 463 UNP H6X1Z1 VAL 463 ENGINEERED MUTATION SEQADV 9CB1 GLY H 491 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 492 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 493 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER H 494 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 495 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TYR H 496 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ILE H 497 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO H 498 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU H 499 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA H 500 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO H 501 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG H 502 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ASP H 503 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 504 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN H 505 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA H 506 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TYR H 507 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL H 508 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG H 509 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LYS H 510 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ASP H 511 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 512 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU H 513 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TRP H 514 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL H 515 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU H 516 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU H 517 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER H 518 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 THR H 519 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE H 520 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU H 521 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 522 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG H 523 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER H 524 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU H 525 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU H 526 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL H 527 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU H 528 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE H 529 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN H 530 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 531 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO H 532 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY H 533 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 534 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 535 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 536 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 537 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 538 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 539 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 540 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 541 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER H 542 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA H 543 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TRP H 544 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER H 545 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS H 546 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO H 547 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN H 548 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE H 549 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU H 550 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LYS H 551 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 CYS I 84 UNP H6X1Z1 VAL 84 ENGINEERED MUTATION SEQADV 9CB1 ARG I 100 UNP H6X1Z1 GLN 100 ENGINEERED MUTATION SEQADV 9CB1 ARG I 101 UNP H6X1Z1 SER 101 ENGINEERED MUTATION SEQADV 9CB1 CYS I 110 UNP H6X1Z1 LEU 110 ENGINEERED MUTATION SEQADV 9CB1 CYS I 127 UNP H6X1Z1 THR 127 ENGINEERED MUTATION SEQADV 9CB1 CYS I 140 UNP H6X1Z1 ALA 140 ENGINEERED MUTATION SEQADV 9CB1 CYS I 147 UNP H6X1Z1 ALA 147 ENGINEERED MUTATION SEQADV 9CB1 CYS I 153 UNP H6X1Z1 ASN 153 ENGINEERED MUTATION SEQADV 9CB1 PRO I 185 UNP H6X1Z1 ALA 185 ENGINEERED MUTATION SEQADV 9CB1 LYS I 219 UNP H6X1Z1 LEU 219 ENGINEERED MUTATION SEQADV 9CB1 ILE I 231 UNP H6X1Z1 VAL 231 ENGINEERED MUTATION SEQADV 9CB1 CYS I 249 UNP H6X1Z1 ALA 249 ENGINEERED MUTATION SEQADV 9CB1 CYS I 322 UNP H6X1Z1 ASN 322 ENGINEERED MUTATION SEQADV 9CB1 CYS I 365 UNP H6X1Z1 THR 365 ENGINEERED MUTATION SEQADV 9CB1 GLN I 453 UNP H6X1Z1 GLU 453 ENGINEERED MUTATION SEQADV 9CB1 CYS I 463 UNP H6X1Z1 VAL 463 ENGINEERED MUTATION SEQADV 9CB1 GLY I 491 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 492 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 493 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER I 494 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 495 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TYR I 496 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ILE I 497 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO I 498 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU I 499 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA I 500 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO I 501 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG I 502 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ASP I 503 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 504 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN I 505 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA I 506 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TYR I 507 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL I 508 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG I 509 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LYS I 510 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ASP I 511 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 512 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU I 513 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TRP I 514 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL I 515 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU I 516 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU I 517 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER I 518 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 THR I 519 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE I 520 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU I 521 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 522 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ARG I 523 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER I 524 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU I 525 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU I 526 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 VAL I 527 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LEU I 528 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE I 529 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN I 530 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 531 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO I 532 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLY I 533 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 534 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 535 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 536 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 537 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 538 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 539 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 540 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 541 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER I 542 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 ALA I 543 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 TRP I 544 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 SER I 545 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 HIS I 546 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PRO I 547 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLN I 548 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 PHE I 549 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 GLU I 550 UNP H6X1Z1 EXPRESSION TAG SEQADV 9CB1 LYS I 551 UNP H6X1Z1 EXPRESSION TAG SEQRES 1 A 219 GLN GLY GLN LEU VAL GLN SER GLY PRO GLU VAL LYS LYS SEQRES 2 A 219 PRO GLY ALA THR VAL LYS VAL SER CYS ARG ALA SER ALA SEQRES 3 A 219 TYR PRO PHE GLY ASN TYR GLY ILE THR TRP VAL ARG GLN SEQRES 4 A 219 VAL PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE SER SEQRES 5 A 219 ALA TYR THR GLY HIS THR LYS PHE PRO GLN ASN PHE GLN SEQRES 6 A 219 GLY ARG VAL THR LEU THR ALA ASP THR SER THR SER THR SEQRES 7 A 219 GLY TYR MET GLU LEU ARG SER LEU THR SER ASP ASP THR SEQRES 8 A 219 ALA VAL TYR TYR CYS ALA ARG GLY PRO CYS CYS SER SER SEQRES 9 A 219 PRO ARG PRO TYR ASP ILE TRP GLY GLN GLY THR MET VAL SEQRES 10 A 219 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 A 219 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 A 219 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 A 219 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 A 219 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 A 219 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 A 219 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 A 219 LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 1 B 219 GLN GLY GLN LEU VAL GLN SER GLY PRO GLU VAL LYS LYS SEQRES 2 B 219 PRO GLY ALA THR VAL LYS VAL SER CYS ARG ALA SER ALA SEQRES 3 B 219 TYR PRO PHE GLY ASN TYR GLY ILE THR TRP VAL ARG GLN SEQRES 4 B 219 VAL PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE SER SEQRES 5 B 219 ALA TYR THR GLY HIS THR LYS PHE PRO GLN ASN PHE GLN SEQRES 6 B 219 GLY ARG VAL THR LEU THR ALA ASP THR SER THR SER THR SEQRES 7 B 219 GLY TYR MET GLU LEU ARG SER LEU THR SER ASP ASP THR SEQRES 8 B 219 ALA VAL TYR TYR CYS ALA ARG GLY PRO CYS CYS SER SER SEQRES 9 B 219 PRO ARG PRO TYR ASP ILE TRP GLY GLN GLY THR MET VAL SEQRES 10 B 219 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 B 219 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 B 219 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 B 219 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 B 219 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 B 219 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 B 219 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 B 219 LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 1 C 219 GLN GLY GLN LEU VAL GLN SER GLY PRO GLU VAL LYS LYS SEQRES 2 C 219 PRO GLY ALA THR VAL LYS VAL SER CYS ARG ALA SER ALA SEQRES 3 C 219 TYR PRO PHE GLY ASN TYR GLY ILE THR TRP VAL ARG GLN SEQRES 4 C 219 VAL PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE SER SEQRES 5 C 219 ALA TYR THR GLY HIS THR LYS PHE PRO GLN ASN PHE GLN SEQRES 6 C 219 GLY ARG VAL THR LEU THR ALA ASP THR SER THR SER THR SEQRES 7 C 219 GLY TYR MET GLU LEU ARG SER LEU THR SER ASP ASP THR SEQRES 8 C 219 ALA VAL TYR TYR CYS ALA ARG GLY PRO CYS CYS SER SER SEQRES 9 C 219 PRO ARG PRO TYR ASP ILE TRP GLY GLN GLY THR MET VAL SEQRES 10 C 219 THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 C 219 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 C 219 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 C 219 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 C 219 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 C 219 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 C 219 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 C 219 LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 1 D 214 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 D 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 D 214 GLN SER ILE ASP ASP TRP LEU ALA TRP TYR GLN HIS SER SEQRES 4 D 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ARG ALA SER SEQRES 5 D 214 ARG LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 D 214 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 D 214 GLN PRO ASP ASP PHE ALA SER TYR TYR CYS GLN GLN CYS SEQRES 8 D 214 TYR THR TYR SER GLN THR PHE GLY GLN GLY THR ARG VAL SEQRES 9 D 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 D 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 D 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 D 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 D 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 D 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 D 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 D 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 D 214 PHE ASN ARG GLY GLU CYS SEQRES 1 E 214 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 E 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 E 214 GLN SER ILE ASP ASP TRP LEU ALA TRP TYR GLN HIS SER SEQRES 4 E 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ARG ALA SER SEQRES 5 E 214 ARG LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 E 214 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 E 214 GLN PRO ASP ASP PHE ALA SER TYR TYR CYS GLN GLN CYS SEQRES 8 E 214 TYR THR TYR SER GLN THR PHE GLY GLN GLY THR ARG VAL SEQRES 9 E 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 E 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 E 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 E 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 E 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 E 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 E 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 E 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 E 214 PHE ASN ARG GLY GLU CYS SEQRES 1 F 214 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 F 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 F 214 GLN SER ILE ASP ASP TRP LEU ALA TRP TYR GLN HIS SER SEQRES 4 F 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ARG ALA SER SEQRES 5 F 214 ARG LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 F 214 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 F 214 GLN PRO ASP ASP PHE ALA SER TYR TYR CYS GLN GLN CYS SEQRES 8 F 214 TYR THR TYR SER GLN THR PHE GLY GLN GLY THR ARG VAL SEQRES 9 F 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 F 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 F 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 F 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 F 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 F 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 F 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 F 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 F 214 PHE ASN ARG GLY GLU CYS SEQRES 1 G 551 MET SER TRP LYS VAL VAL ILE ILE PHE SER LEU LEU ILE SEQRES 2 G 551 THR PRO GLN HIS GLY LEU LYS GLU SER TYR LEU GLU GLU SEQRES 3 G 551 SER CYS SER THR ILE THR GLU GLY TYR LEU SER VAL LEU SEQRES 4 G 551 ARG THR GLY TRP TYR THR ASN VAL PHE THR LEU GLU VAL SEQRES 5 G 551 GLY ASP VAL GLU ASN LEU THR CYS ALA ASP GLY PRO SER SEQRES 6 G 551 LEU ILE LYS THR GLU LEU ASP LEU THR LYS SER ALA LEU SEQRES 7 G 551 ARG GLU LEU ARG THR CYS SER ALA ASP GLN LEU ALA ARG SEQRES 8 G 551 GLU GLU GLN ILE GLU ASN PRO ARG ARG ARG ARG PHE VAL SEQRES 9 G 551 LEU GLY ALA ILE ALA CYS GLY VAL ALA THR ALA ALA ALA SEQRES 10 G 551 VAL THR ALA GLY VAL ALA ILE ALA LYS CYS ILE ARG LEU SEQRES 11 G 551 GLU SER GLU VAL THR ALA ILE LYS ASN CYS LEU LYS LYS SEQRES 12 G 551 THR ASN GLU CYS VAL SER THR LEU GLY CYS GLY VAL ARG SEQRES 13 G 551 VAL LEU ALA THR ALA VAL ARG GLU LEU LYS ASP PHE VAL SEQRES 14 G 551 SER LYS ASN LEU THR ARG ALA ILE ASN LYS ASN LYS CYS SEQRES 15 G 551 ASP ILE PRO ASP LEU LYS MET ALA VAL SER PHE SER GLN SEQRES 16 G 551 PHE ASN ARG ARG PHE LEU ASN VAL VAL ARG GLN PHE SER SEQRES 17 G 551 ASP ASN ALA GLY ILE THR PRO ALA ILE SER LYS ASP LEU SEQRES 18 G 551 MET THR ASP ALA GLU LEU ALA ARG ALA ILE SER ASN MET SEQRES 19 G 551 PRO THR SER ALA GLY GLN ILE LYS LEU MET LEU GLU ASN SEQRES 20 G 551 ARG CYS MET VAL ARG ARG LYS GLY PHE GLY ILE LEU ILE SEQRES 21 G 551 GLY VAL TYR GLY SER SER VAL ILE TYR MET VAL GLN LEU SEQRES 22 G 551 PRO ILE PHE GLY VAL ILE ASP THR PRO CYS TRP ILE VAL SEQRES 23 G 551 LYS ALA ALA PRO SER CYS SER GLU LYS LYS GLY ASN TYR SEQRES 24 G 551 ALA CYS LEU LEU ARG GLU ASP GLN GLY TRP TYR CYS GLN SEQRES 25 G 551 ASN ALA GLY SER THR VAL TYR TYR PRO CYS GLU LYS ASP SEQRES 26 G 551 CYS GLU THR ARG GLY ASP HIS VAL PHE CYS ASP THR ALA SEQRES 27 G 551 ALA GLY ILE ASN VAL ALA GLU GLN SER LYS GLU CYS ASN SEQRES 28 G 551 ILE ASN ILE SER THR THR ASN TYR PRO CYS LYS VAL SER SEQRES 29 G 551 CYS GLY ARG HIS PRO ILE SER MET VAL ALA LEU SER PRO SEQRES 30 G 551 LEU GLY ALA LEU VAL ALA CYS TYR LYS GLY VAL SER CYS SEQRES 31 G 551 SER ILE GLY SER ASN ARG VAL GLY ILE ILE LYS GLN LEU SEQRES 32 G 551 ASN LYS GLY CYS SER TYR ILE THR ASN GLN ASP ALA ASP SEQRES 33 G 551 THR VAL THR ILE ASP ASN THR VAL TYR GLN LEU SER LYS SEQRES 34 G 551 VAL GLU GLY GLU GLN HIS VAL ILE LYS GLY ARG PRO VAL SEQRES 35 G 551 SER SER SER PHE ASP PRO VAL LYS PHE PRO GLN ASP GLN SEQRES 36 G 551 PHE ASN VAL ALA LEU ASP GLN CYS PHE GLU SER ILE GLU SEQRES 37 G 551 ASN SER GLN ALA LEU VAL ASP GLN SER ASN ARG ILE LEU SEQRES 38 G 551 SER SER ALA GLU LYS GLY ASN THR GLY GLY GLY GLY SER SEQRES 39 G 551 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 40 G 551 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 41 G 551 LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY SEQRES 42 G 551 HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS SEQRES 43 G 551 PRO GLN PHE GLU LYS SEQRES 1 H 551 MET SER TRP LYS VAL VAL ILE ILE PHE SER LEU LEU ILE SEQRES 2 H 551 THR PRO GLN HIS GLY LEU LYS GLU SER TYR LEU GLU GLU SEQRES 3 H 551 SER CYS SER THR ILE THR GLU GLY TYR LEU SER VAL LEU SEQRES 4 H 551 ARG THR GLY TRP TYR THR ASN VAL PHE THR LEU GLU VAL SEQRES 5 H 551 GLY ASP VAL GLU ASN LEU THR CYS ALA ASP GLY PRO SER SEQRES 6 H 551 LEU ILE LYS THR GLU LEU ASP LEU THR LYS SER ALA LEU SEQRES 7 H 551 ARG GLU LEU ARG THR CYS SER ALA ASP GLN LEU ALA ARG SEQRES 8 H 551 GLU GLU GLN ILE GLU ASN PRO ARG ARG ARG ARG PHE VAL SEQRES 9 H 551 LEU GLY ALA ILE ALA CYS GLY VAL ALA THR ALA ALA ALA SEQRES 10 H 551 VAL THR ALA GLY VAL ALA ILE ALA LYS CYS ILE ARG LEU SEQRES 11 H 551 GLU SER GLU VAL THR ALA ILE LYS ASN CYS LEU LYS LYS SEQRES 12 H 551 THR ASN GLU CYS VAL SER THR LEU GLY CYS GLY VAL ARG SEQRES 13 H 551 VAL LEU ALA THR ALA VAL ARG GLU LEU LYS ASP PHE VAL SEQRES 14 H 551 SER LYS ASN LEU THR ARG ALA ILE ASN LYS ASN LYS CYS SEQRES 15 H 551 ASP ILE PRO ASP LEU LYS MET ALA VAL SER PHE SER GLN SEQRES 16 H 551 PHE ASN ARG ARG PHE LEU ASN VAL VAL ARG GLN PHE SER SEQRES 17 H 551 ASP ASN ALA GLY ILE THR PRO ALA ILE SER LYS ASP LEU SEQRES 18 H 551 MET THR ASP ALA GLU LEU ALA ARG ALA ILE SER ASN MET SEQRES 19 H 551 PRO THR SER ALA GLY GLN ILE LYS LEU MET LEU GLU ASN SEQRES 20 H 551 ARG CYS MET VAL ARG ARG LYS GLY PHE GLY ILE LEU ILE SEQRES 21 H 551 GLY VAL TYR GLY SER SER VAL ILE TYR MET VAL GLN LEU SEQRES 22 H 551 PRO ILE PHE GLY VAL ILE ASP THR PRO CYS TRP ILE VAL SEQRES 23 H 551 LYS ALA ALA PRO SER CYS SER GLU LYS LYS GLY ASN TYR SEQRES 24 H 551 ALA CYS LEU LEU ARG GLU ASP GLN GLY TRP TYR CYS GLN SEQRES 25 H 551 ASN ALA GLY SER THR VAL TYR TYR PRO CYS GLU LYS ASP SEQRES 26 H 551 CYS GLU THR ARG GLY ASP HIS VAL PHE CYS ASP THR ALA SEQRES 27 H 551 ALA GLY ILE ASN VAL ALA GLU GLN SER LYS GLU CYS ASN SEQRES 28 H 551 ILE ASN ILE SER THR THR ASN TYR PRO CYS LYS VAL SER SEQRES 29 H 551 CYS GLY ARG HIS PRO ILE SER MET VAL ALA LEU SER PRO SEQRES 30 H 551 LEU GLY ALA LEU VAL ALA CYS TYR LYS GLY VAL SER CYS SEQRES 31 H 551 SER ILE GLY SER ASN ARG VAL GLY ILE ILE LYS GLN LEU SEQRES 32 H 551 ASN LYS GLY CYS SER TYR ILE THR ASN GLN ASP ALA ASP SEQRES 33 H 551 THR VAL THR ILE ASP ASN THR VAL TYR GLN LEU SER LYS SEQRES 34 H 551 VAL GLU GLY GLU GLN HIS VAL ILE LYS GLY ARG PRO VAL SEQRES 35 H 551 SER SER SER PHE ASP PRO VAL LYS PHE PRO GLN ASP GLN SEQRES 36 H 551 PHE ASN VAL ALA LEU ASP GLN CYS PHE GLU SER ILE GLU SEQRES 37 H 551 ASN SER GLN ALA LEU VAL ASP GLN SER ASN ARG ILE LEU SEQRES 38 H 551 SER SER ALA GLU LYS GLY ASN THR GLY GLY GLY GLY SER SEQRES 39 H 551 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 40 H 551 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 41 H 551 LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY SEQRES 42 H 551 HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS SEQRES 43 H 551 PRO GLN PHE GLU LYS SEQRES 1 I 551 MET SER TRP LYS VAL VAL ILE ILE PHE SER LEU LEU ILE SEQRES 2 I 551 THR PRO GLN HIS GLY LEU LYS GLU SER TYR LEU GLU GLU SEQRES 3 I 551 SER CYS SER THR ILE THR GLU GLY TYR LEU SER VAL LEU SEQRES 4 I 551 ARG THR GLY TRP TYR THR ASN VAL PHE THR LEU GLU VAL SEQRES 5 I 551 GLY ASP VAL GLU ASN LEU THR CYS ALA ASP GLY PRO SER SEQRES 6 I 551 LEU ILE LYS THR GLU LEU ASP LEU THR LYS SER ALA LEU SEQRES 7 I 551 ARG GLU LEU ARG THR CYS SER ALA ASP GLN LEU ALA ARG SEQRES 8 I 551 GLU GLU GLN ILE GLU ASN PRO ARG ARG ARG ARG PHE VAL SEQRES 9 I 551 LEU GLY ALA ILE ALA CYS GLY VAL ALA THR ALA ALA ALA SEQRES 10 I 551 VAL THR ALA GLY VAL ALA ILE ALA LYS CYS ILE ARG LEU SEQRES 11 I 551 GLU SER GLU VAL THR ALA ILE LYS ASN CYS LEU LYS LYS SEQRES 12 I 551 THR ASN GLU CYS VAL SER THR LEU GLY CYS GLY VAL ARG SEQRES 13 I 551 VAL LEU ALA THR ALA VAL ARG GLU LEU LYS ASP PHE VAL SEQRES 14 I 551 SER LYS ASN LEU THR ARG ALA ILE ASN LYS ASN LYS CYS SEQRES 15 I 551 ASP ILE PRO ASP LEU LYS MET ALA VAL SER PHE SER GLN SEQRES 16 I 551 PHE ASN ARG ARG PHE LEU ASN VAL VAL ARG GLN PHE SER SEQRES 17 I 551 ASP ASN ALA GLY ILE THR PRO ALA ILE SER LYS ASP LEU SEQRES 18 I 551 MET THR ASP ALA GLU LEU ALA ARG ALA ILE SER ASN MET SEQRES 19 I 551 PRO THR SER ALA GLY GLN ILE LYS LEU MET LEU GLU ASN SEQRES 20 I 551 ARG CYS MET VAL ARG ARG LYS GLY PHE GLY ILE LEU ILE SEQRES 21 I 551 GLY VAL TYR GLY SER SER VAL ILE TYR MET VAL GLN LEU SEQRES 22 I 551 PRO ILE PHE GLY VAL ILE ASP THR PRO CYS TRP ILE VAL SEQRES 23 I 551 LYS ALA ALA PRO SER CYS SER GLU LYS LYS GLY ASN TYR SEQRES 24 I 551 ALA CYS LEU LEU ARG GLU ASP GLN GLY TRP TYR CYS GLN SEQRES 25 I 551 ASN ALA GLY SER THR VAL TYR TYR PRO CYS GLU LYS ASP SEQRES 26 I 551 CYS GLU THR ARG GLY ASP HIS VAL PHE CYS ASP THR ALA SEQRES 27 I 551 ALA GLY ILE ASN VAL ALA GLU GLN SER LYS GLU CYS ASN SEQRES 28 I 551 ILE ASN ILE SER THR THR ASN TYR PRO CYS LYS VAL SER SEQRES 29 I 551 CYS GLY ARG HIS PRO ILE SER MET VAL ALA LEU SER PRO SEQRES 30 I 551 LEU GLY ALA LEU VAL ALA CYS TYR LYS GLY VAL SER CYS SEQRES 31 I 551 SER ILE GLY SER ASN ARG VAL GLY ILE ILE LYS GLN LEU SEQRES 32 I 551 ASN LYS GLY CYS SER TYR ILE THR ASN GLN ASP ALA ASP SEQRES 33 I 551 THR VAL THR ILE ASP ASN THR VAL TYR GLN LEU SER LYS SEQRES 34 I 551 VAL GLU GLY GLU GLN HIS VAL ILE LYS GLY ARG PRO VAL SEQRES 35 I 551 SER SER SER PHE ASP PRO VAL LYS PHE PRO GLN ASP GLN SEQRES 36 I 551 PHE ASN VAL ALA LEU ASP GLN CYS PHE GLU SER ILE GLU SEQRES 37 I 551 ASN SER GLN ALA LEU VAL ASP GLN SER ASN ARG ILE LEU SEQRES 38 I 551 SER SER ALA GLU LYS GLY ASN THR GLY GLY GLY GLY SER SEQRES 39 I 551 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 40 I 551 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 41 I 551 LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY SEQRES 42 I 551 HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS SEQRES 43 I 551 PRO GLN PHE GLU LYS HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HET NAG L 1 14 HET NAG L 2 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 10 NAG 6(C8 H15 N O6) HELIX 1 AA1 PRO A 28 ASN A 31 5 4 HELIX 2 AA2 THR A 83 THR A 87 5 5 HELIX 3 AA3 PRO B 28 ASN B 31 5 4 HELIX 4 AA4 THR B 83 THR B 87 5 5 HELIX 5 AA5 PRO C 28 ASN C 31 5 4 HELIX 6 AA6 THR C 83 THR C 87 5 5 HELIX 7 AA7 GLN D 79 PHE D 83 5 5 HELIX 8 AA8 GLN E 79 PHE E 83 5 5 HELIX 9 AA9 GLN F 79 PHE F 83 5 5 HELIX 10 AB1 SER G 65 SER G 85 1 21 HELIX 11 AB2 VAL G 104 CYS G 110 1 7 HELIX 12 AB3 GLY G 111 ARG G 129 1 19 HELIX 13 AB4 LEU G 130 LEU G 141 1 12 HELIX 14 AB5 ARG G 163 ASN G 172 1 10 HELIX 15 AB6 ASN G 172 ILE G 177 1 6 HELIX 16 AB7 ASP G 186 ASN G 210 1 25 HELIX 17 AB8 THR G 223 ASN G 233 1 11 HELIX 18 AB9 SER G 237 ASN G 247 1 11 HELIX 19 AC1 ASN G 247 GLY G 255 1 9 HELIX 20 AC2 CYS G 322 LYS G 324 5 3 HELIX 21 AC3 ALA G 338 GLY G 340 5 3 HELIX 22 AC4 ALA G 344 ILE G 352 5 9 HELIX 23 AC5 PRO G 441 PHE G 446 5 6 HELIX 24 AC6 ALA G 459 PHE G 464 1 6 HELIX 25 AC7 SER H 65 SER H 85 1 21 HELIX 26 AC8 VAL H 104 CYS H 110 1 7 HELIX 27 AC9 GLY H 111 ARG H 129 1 19 HELIX 28 AD1 LEU H 130 LEU H 141 1 12 HELIX 29 AD2 ARG H 163 ASN H 172 1 10 HELIX 30 AD3 ASN H 172 ILE H 177 1 6 HELIX 31 AD4 ASP H 186 ASN H 210 1 25 HELIX 32 AD5 THR H 223 ASN H 233 1 11 HELIX 33 AD6 SER H 237 ASN H 247 1 11 HELIX 34 AD7 ASN H 247 GLY H 255 1 9 HELIX 35 AD8 CYS H 322 LYS H 324 5 3 HELIX 36 AD9 ALA H 338 GLY H 340 5 3 HELIX 37 AE1 ALA H 344 ILE H 352 5 9 HELIX 38 AE2 PRO H 441 PHE H 446 1 6 HELIX 39 AE3 ASP H 447 PHE H 451 5 5 HELIX 40 AE4 SER I 65 SER I 85 1 21 HELIX 41 AE5 VAL I 104 CYS I 110 1 7 HELIX 42 AE6 GLY I 111 ARG I 129 1 19 HELIX 43 AE7 LEU I 130 LEU I 141 1 12 HELIX 44 AE8 ARG I 163 ASN I 172 1 10 HELIX 45 AE9 ASN I 172 ILE I 177 1 6 HELIX 46 AF1 ASP I 186 ASN I 210 1 25 HELIX 47 AF2 THR I 223 ASN I 233 1 11 HELIX 48 AF3 SER I 237 ASN I 247 1 11 HELIX 49 AF4 ASN I 247 GLY I 255 1 9 HELIX 50 AF5 CYS I 322 LYS I 324 5 3 HELIX 51 AF6 ALA I 338 GLY I 340 5 3 HELIX 52 AF7 ALA I 344 ILE I 352 5 9 HELIX 53 AF8 VAL I 442 ASP I 447 1 6 HELIX 54 AF9 ALA I 459 PHE I 464 1 6 SHEET 1 AA1 4 GLN A 3 GLN A 6 0 SHEET 2 AA1 4 VAL A 18 SER A 25 -1 O ARG A 23 N VAL A 5 SHEET 3 AA1 4 THR A 77 LEU A 82 -1 O MET A 80 N VAL A 20 SHEET 4 AA1 4 VAL A 67 ASP A 72 -1 N ASP A 72 O THR A 77 SHEET 1 AA2 6 GLU A 10 VAL A 11 0 SHEET 2 AA2 6 THR A 107 THR A 110 1 O THR A 110 N GLU A 10 SHEET 3 AA2 6 ALA A 88 GLY A 95 -1 N TYR A 90 O THR A 107 SHEET 4 AA2 6 GLY A 33 GLN A 39 -1 N VAL A 37 O TYR A 91 SHEET 5 AA2 6 LEU A 45 SER A 52 -1 O GLY A 49 N TRP A 36 SHEET 6 AA2 6 THR A 57 LYS A 58 -1 O LYS A 58 N TRP A 50 SHEET 1 AA3 4 GLN B 3 GLN B 6 0 SHEET 2 AA3 4 VAL B 18 SER B 25 -1 O ARG B 23 N VAL B 5 SHEET 3 AA3 4 THR B 77 LEU B 82 -1 O MET B 80 N VAL B 20 SHEET 4 AA3 4 VAL B 67 ASP B 72 -1 N ASP B 72 O THR B 77 SHEET 1 AA4 6 GLU B 10 VAL B 11 0 SHEET 2 AA4 6 THR B 107 THR B 110 1 O THR B 110 N GLU B 10 SHEET 3 AA4 6 ALA B 88 GLY B 95 -1 N TYR B 90 O THR B 107 SHEET 4 AA4 6 GLY B 33 GLN B 39 -1 N VAL B 37 O TYR B 91 SHEET 5 AA4 6 LEU B 45 SER B 52 -1 O GLY B 49 N TRP B 36 SHEET 6 AA4 6 THR B 57 LYS B 58 -1 O LYS B 58 N TRP B 50 SHEET 1 AA5 4 GLN C 3 GLN C 6 0 SHEET 2 AA5 4 VAL C 18 SER C 25 -1 O ARG C 23 N VAL C 5 SHEET 3 AA5 4 THR C 77 LEU C 82 -1 O MET C 80 N VAL C 20 SHEET 4 AA5 4 VAL C 67 ASP C 72 -1 N ASP C 72 O THR C 77 SHEET 1 AA6 6 GLU C 10 VAL C 11 0 SHEET 2 AA6 6 THR C 107 THR C 110 1 O THR C 110 N GLU C 10 SHEET 3 AA6 6 ALA C 88 GLY C 95 -1 N TYR C 90 O THR C 107 SHEET 4 AA6 6 GLY C 33 GLN C 39 -1 N VAL C 37 O TYR C 91 SHEET 5 AA6 6 LEU C 45 SER C 52 -1 O VAL C 48 N TRP C 36 SHEET 6 AA6 6 THR C 57 LYS C 58 -1 O LYS C 58 N TRP C 50 SHEET 1 AA7 4 MET D 4 SER D 7 0 SHEET 2 AA7 4 VAL D 19 ALA D 25 -1 O THR D 22 N SER D 7 SHEET 3 AA7 4 GLU D 70 ILE D 75 -1 O LEU D 73 N ILE D 21 SHEET 4 AA7 4 PHE D 62 SER D 67 -1 N SER D 63 O THR D 74 SHEET 1 AA8 6 THR D 10 ALA D 13 0 SHEET 2 AA8 6 THR D 102 ILE D 106 1 O ARG D 103 N LEU D 11 SHEET 3 AA8 6 SER D 85 GLN D 90 -1 N TYR D 86 O THR D 102 SHEET 4 AA8 6 LEU D 33 HIS D 38 -1 N ALA D 34 O GLN D 89 SHEET 5 AA8 6 LYS D 45 TYR D 49 -1 O LYS D 45 N GLN D 37 SHEET 6 AA8 6 ARG D 53 LEU D 54 -1 O ARG D 53 N TYR D 49 SHEET 1 AA9 4 MET E 4 SER E 7 0 SHEET 2 AA9 4 VAL E 19 ALA E 25 -1 O THR E 22 N SER E 7 SHEET 3 AA9 4 GLU E 70 ILE E 75 -1 O LEU E 73 N ILE E 21 SHEET 4 AA9 4 PHE E 62 SER E 67 -1 N SER E 63 O THR E 74 SHEET 1 AB1 6 THR E 10 ALA E 13 0 SHEET 2 AB1 6 THR E 102 ILE E 106 1 O GLU E 105 N LEU E 11 SHEET 3 AB1 6 SER E 85 GLN E 90 -1 N TYR E 86 O THR E 102 SHEET 4 AB1 6 LEU E 33 HIS E 38 -1 N ALA E 34 O GLN E 89 SHEET 5 AB1 6 LYS E 45 TYR E 49 -1 O LYS E 45 N GLN E 37 SHEET 6 AB1 6 ARG E 53 LEU E 54 -1 O ARG E 53 N TYR E 49 SHEET 1 AB2 4 MET F 4 SER F 7 0 SHEET 2 AB2 4 VAL F 19 ALA F 25 -1 O THR F 22 N SER F 7 SHEET 3 AB2 4 GLU F 70 ILE F 75 -1 O LEU F 73 N ILE F 21 SHEET 4 AB2 4 PHE F 62 SER F 67 -1 N SER F 63 O THR F 74 SHEET 1 AB3 6 THR F 10 ALA F 13 0 SHEET 2 AB3 6 THR F 102 ILE F 106 1 O ARG F 103 N LEU F 11 SHEET 3 AB3 6 SER F 85 GLN F 90 -1 N TYR F 86 O THR F 102 SHEET 4 AB3 6 LEU F 33 HIS F 38 -1 N ALA F 34 O GLN F 89 SHEET 5 AB3 6 PRO F 44 TYR F 49 -1 O LYS F 45 N GLN F 37 SHEET 6 AB3 6 ARG F 53 LEU F 54 -1 O ARG F 53 N TYR F 49 SHEET 1 AB4 6 VAL G 278 ILE G 279 0 SHEET 2 AB4 6 SER G 29 ARG G 40 -1 N LEU G 39 O VAL G 278 SHEET 3 AB4 6 CYS G 283 ALA G 288 -1 O CYS G 283 N TYR G 35 SHEET 4 AB4 6 GLY G 308 ASN G 313 -1 O TYR G 310 N TRP G 284 SHEET 5 AB4 6 SER G 316 TYR G 320 -1 O SER G 316 N ASN G 313 SHEET 6 AB4 6 ILE G 341 VAL G 343 -1 O VAL G 343 N THR G 317 SHEET 1 AB5 5 CYS G 326 ARG G 329 0 SHEET 2 AB5 5 HIS G 332 ASP G 336 -1 O PHE G 334 N GLU G 327 SHEET 3 AB5 5 SER G 29 ARG G 40 1 N LEU G 36 O VAL G 333 SHEET 4 AB5 5 LYS G 20 LEU G 24 -1 N LEU G 24 O SER G 29 SHEET 5 AB5 5 GLU G 433 ILE G 437 1 O HIS G 435 N TYR G 23 SHEET 1 AB6 5 GLU G 146 THR G 150 0 SHEET 2 AB6 5 ARG G 156 VAL G 162 -1 O ALA G 159 N CYS G 147 SHEET 3 AB6 5 GLY G 42 GLU G 51 1 N VAL G 47 O THR G 160 SHEET 4 AB6 5 SER G 266 ILE G 275 -1 O ILE G 275 N GLY G 42 SHEET 5 AB6 5 PHE G 256 TYR G 263 -1 N ILE G 258 O MET G 270 SHEET 1 AB7 3 SER G 291 LYS G 295 0 SHEET 2 AB7 3 ASN G 298 ARG G 304 -1 O LEU G 302 N SER G 291 SHEET 3 AB7 3 VAL G 363 GLY G 366 -1 O SER G 364 N LEU G 303 SHEET 1 AB8 3 MET G 372 LEU G 375 0 SHEET 2 AB8 3 GLY G 379 CYS G 384 -1 O LEU G 381 N ALA G 374 SHEET 3 AB8 3 GLY G 406 THR G 411 -1 O GLY G 406 N CYS G 384 SHEET 1 AB9 4 GLY G 398 GLN G 402 0 SHEET 2 AB9 4 CYS G 390 SER G 394 -1 N SER G 394 O GLY G 398 SHEET 3 AB9 4 THR G 417 ILE G 420 -1 O THR G 417 N GLY G 393 SHEET 4 AB9 4 THR G 423 GLN G 426 -1 O THR G 423 N ILE G 420 SHEET 1 AC1 6 VAL H 278 ILE H 279 0 SHEET 2 AC1 6 SER H 29 ARG H 40 -1 N LEU H 39 O VAL H 278 SHEET 3 AC1 6 CYS H 283 ALA H 288 -1 O CYS H 283 N TYR H 35 SHEET 4 AC1 6 GLY H 308 ASN H 313 -1 O TYR H 310 N TRP H 284 SHEET 5 AC1 6 SER H 316 TYR H 320 -1 O SER H 316 N ASN H 313 SHEET 6 AC1 6 ILE H 341 VAL H 343 -1 O VAL H 343 N THR H 317 SHEET 1 AC2 5 CYS H 326 ARG H 329 0 SHEET 2 AC2 5 HIS H 332 ASP H 336 -1 O PHE H 334 N GLU H 327 SHEET 3 AC2 5 SER H 29 ARG H 40 1 N LEU H 36 O VAL H 333 SHEET 4 AC2 5 LYS H 20 LEU H 24 -1 N LEU H 24 O SER H 29 SHEET 5 AC2 5 GLU H 433 ILE H 437 1 O HIS H 435 N TYR H 23 SHEET 1 AC3 5 GLU H 146 THR H 150 0 SHEET 2 AC3 5 ARG H 156 VAL H 162 -1 O ALA H 159 N CYS H 147 SHEET 3 AC3 5 GLY H 42 GLU H 51 1 N VAL H 47 O THR H 160 SHEET 4 AC3 5 SER H 266 ILE H 275 -1 O ILE H 275 N GLY H 42 SHEET 5 AC3 5 PHE H 256 TYR H 263 -1 N ILE H 258 O MET H 270 SHEET 1 AC4 3 SER H 291 LYS H 295 0 SHEET 2 AC4 3 ASN H 298 ARG H 304 -1 O LEU H 302 N SER H 291 SHEET 3 AC4 3 VAL H 363 GLY H 366 -1 O SER H 364 N LEU H 303 SHEET 1 AC5 3 MET H 372 LEU H 375 0 SHEET 2 AC5 3 GLY H 379 CYS H 384 -1 O LEU H 381 N ALA H 374 SHEET 3 AC5 3 GLY H 406 THR H 411 -1 O GLY H 406 N CYS H 384 SHEET 1 AC6 4 GLY H 398 GLN H 402 0 SHEET 2 AC6 4 CYS H 390 SER H 394 -1 N SER H 394 O GLY H 398 SHEET 3 AC6 4 THR H 417 ILE H 420 -1 O THR H 417 N GLY H 393 SHEET 4 AC6 4 THR H 423 GLN H 426 -1 O THR H 423 N ILE H 420 SHEET 1 AC7 6 VAL I 278 ILE I 279 0 SHEET 2 AC7 6 SER I 29 ARG I 40 -1 N LEU I 39 O VAL I 278 SHEET 3 AC7 6 CYS I 283 ALA I 288 -1 O CYS I 283 N TYR I 35 SHEET 4 AC7 6 GLY I 308 ASN I 313 -1 O TYR I 310 N TRP I 284 SHEET 5 AC7 6 SER I 316 TYR I 320 -1 O SER I 316 N ASN I 313 SHEET 6 AC7 6 ILE I 341 VAL I 343 -1 O VAL I 343 N THR I 317 SHEET 1 AC8 5 CYS I 326 ARG I 329 0 SHEET 2 AC8 5 HIS I 332 ASP I 336 -1 O PHE I 334 N GLU I 327 SHEET 3 AC8 5 SER I 29 ARG I 40 1 N LEU I 36 O VAL I 333 SHEET 4 AC8 5 LYS I 20 LEU I 24 -1 N LEU I 24 O SER I 29 SHEET 5 AC8 5 GLU I 433 ILE I 437 1 O HIS I 435 N TYR I 23 SHEET 1 AC9 5 GLU I 146 THR I 150 0 SHEET 2 AC9 5 ARG I 156 VAL I 162 -1 O ALA I 159 N CYS I 147 SHEET 3 AC9 5 GLY I 42 GLU I 51 1 N VAL I 47 O THR I 160 SHEET 4 AC9 5 SER I 266 ILE I 275 -1 O ILE I 275 N GLY I 42 SHEET 5 AC9 5 PHE I 256 TYR I 263 -1 N ILE I 258 O MET I 270 SHEET 1 AD1 4 SER I 291 CYS I 292 0 SHEET 2 AD1 4 CYS I 301 ARG I 304 -1 O LEU I 302 N SER I 291 SHEET 3 AD1 4 VAL I 363 GLY I 366 -1 O GLY I 366 N CYS I 301 SHEET 4 AD1 4 GLN I 455 VAL I 458 -1 O VAL I 458 N VAL I 363 SHEET 1 AD2 3 MET I 372 SER I 376 0 SHEET 2 AD2 3 GLY I 379 CYS I 384 -1 O GLY I 379 N SER I 376 SHEET 3 AD2 3 GLY I 406 THR I 411 -1 O GLY I 406 N CYS I 384 SHEET 1 AD3 4 GLY I 398 GLN I 402 0 SHEET 2 AD3 4 CYS I 390 SER I 394 -1 N SER I 394 O GLY I 398 SHEET 3 AD3 4 THR I 417 ILE I 420 -1 O THR I 417 N GLY I 393 SHEET 4 AD3 4 THR I 423 GLN I 426 -1 O THR I 423 N ILE I 420 SSBOND 1 CYS A 22 CYS A 92 1555 1555 2.03 SSBOND 2 CYS A 97 CYS A 98 1555 1555 2.06 SSBOND 3 CYS B 22 CYS B 92 1555 1555 2.03 SSBOND 4 CYS B 97 CYS B 98 1555 1555 2.06 SSBOND 5 CYS C 22 CYS C 92 1555 1555 2.03 SSBOND 6 CYS C 97 CYS C 98 1555 1555 2.06 SSBOND 7 CYS D 23 CYS D 88 1555 1555 2.04 SSBOND 8 CYS E 23 CYS E 88 1555 1555 2.04 SSBOND 9 CYS F 23 CYS F 88 1555 1555 2.04 SSBOND 10 CYS G 28 CYS G 407 1555 1555 2.03 SSBOND 11 CYS G 60 CYS G 182 1555 1555 2.03 SSBOND 12 CYS G 84 CYS H 249 1555 1555 2.03 SSBOND 13 CYS G 110 CYS G 322 1555 1555 2.03 SSBOND 14 CYS G 127 CYS G 153 1555 1555 2.04 SSBOND 15 CYS G 140 CYS G 147 1555 1555 2.03 SSBOND 16 CYS G 249 CYS I 84 1555 1555 2.03 SSBOND 17 CYS G 283 CYS G 311 1555 1555 2.03 SSBOND 18 CYS G 292 CYS G 301 1555 1555 2.03 SSBOND 19 CYS G 326 CYS G 335 1555 1555 2.03 SSBOND 20 CYS G 350 CYS G 361 1555 1555 2.03 SSBOND 21 CYS G 365 CYS G 463 1555 1555 2.03 SSBOND 22 CYS G 384 CYS G 390 1555 1555 2.03 SSBOND 23 CYS H 28 CYS H 407 1555 1555 2.03 SSBOND 24 CYS H 60 CYS H 182 1555 1555 2.03 SSBOND 25 CYS H 84 CYS I 249 1555 1555 2.03 SSBOND 26 CYS H 110 CYS H 322 1555 1555 2.03 SSBOND 27 CYS H 127 CYS H 153 1555 1555 2.04 SSBOND 28 CYS H 140 CYS H 147 1555 1555 2.03 SSBOND 29 CYS H 283 CYS H 311 1555 1555 2.03 SSBOND 30 CYS H 292 CYS H 301 1555 1555 2.03 SSBOND 31 CYS H 326 CYS H 335 1555 1555 2.03 SSBOND 32 CYS H 350 CYS H 361 1555 1555 2.03 SSBOND 33 CYS H 365 CYS H 463 1555 1555 2.03 SSBOND 34 CYS H 384 CYS H 390 1555 1555 2.03 SSBOND 35 CYS I 28 CYS I 407 1555 1555 2.03 SSBOND 36 CYS I 60 CYS I 182 1555 1555 2.03 SSBOND 37 CYS I 110 CYS I 322 1555 1555 2.03 SSBOND 38 CYS I 127 CYS I 153 1555 1555 2.04 SSBOND 39 CYS I 140 CYS I 147 1555 1555 2.03 SSBOND 40 CYS I 283 CYS I 311 1555 1555 2.03 SSBOND 41 CYS I 292 CYS I 301 1555 1555 2.03 SSBOND 42 CYS I 326 CYS I 335 1555 1555 2.03 SSBOND 43 CYS I 350 CYS I 361 1555 1555 2.03 SSBOND 44 CYS I 365 CYS I 463 1555 1555 2.03 SSBOND 45 CYS I 384 CYS I 390 1555 1555 2.03 LINK ND2 ASN G 172 C1 NAG J 1 1555 1555 1.43 LINK ND2 ASN H 172 C1 NAG K 1 1555 1555 1.43 LINK ND2 ASN I 172 C1 NAG L 1 1555 1555 1.45 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.40 CISPEP 1 SER D 7 PRO D 8 0 -2.89 CISPEP 2 SER E 7 PRO E 8 0 -2.02 CISPEP 3 SER F 7 PRO F 8 0 -2.61 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000