HEADER VIRAL PROTEIN/IMMUNE SYSTEM 02-AUG-24 9CYE TITLE CRYO-EM STRUCTURE OF DA03E17 FAB IN COMPLEX WITH INFLUENZA VIRUS TITLE 2 NEURAMINIDASE FROM A/CALIFORNIA/07/2009 (H1N1) COMPND MOL_ID: 1; COMPND 2 MOLECULE: NEURAMINIDASE; COMPND 3 CHAIN: A, B, C, D; COMPND 4 EC: 3.2.1.18; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: DA03E17 FAB HEAVY CHAIN; COMPND 8 CHAIN: H, E, F, G; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: DA03E17 FAB LIGHT CHAIN; COMPND 12 CHAIN: L, I, J, K; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)); SOURCE 3 ORGANISM_TAXID: 641809; SOURCE 4 GENE: NA; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS NEURAMINIDASE, HYDROLASE, ANTIBODY COMPLEX, VIRAL PROTEIN, VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.JO,A.B.WARD REVDAT 1 13-AUG-25 9CYE 0 JRNL AUTH G.JO,S.YAMAYOSHI,K.M.MA,O.SWANSON,J.L.TORRES,J.A.FERGUSON, JRNL AUTH 2 M.L.FERNANDEZ-QUINTERO,J.HUANG,J.COPPS,A.J.RODRIGUEZ, JRNL AUTH 3 J.M.STEICHEN,Y.KAWAOKA,J.HAN,A.B.WARD JRNL TITL STRUCTURAL BASIS OF BROAD PROTECTION AGAINST INFLUENZA VIRUS JRNL TITL 2 BY HUMAN ANTIBODIES TARGETING THE NEURAMINIDASE ACTIVE SITE JRNL TITL 3 VIA A RECURRING MOTIF IN CDR H3. JRNL REF NAT COMMUN V. 16 7067 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 40750588 JRNL DOI 10.1038/S41467-025-62174-2 REMARK 2 REMARK 2 RESOLUTION. 2.70 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, EPU, CRYOSPARC, PHENIX, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.700 REMARK 3 NUMBER OF PARTICLES : 130141 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9CYE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-AUG-24. REMARK 100 THE DEPOSITION ID IS D_1000285652. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : DA03E17 FAB IN COMPLEX WITH REMARK 245 INFLUENZA VIRUS NEURAMINIDASE REMARK 245 FROM A/CALIFORNIA/07/2009 (H1N1) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.40 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4316.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, H, L, B, E, I, C, F, J, D, REMARK 350 AND CHAINS: G, K REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -8 REMARK 465 TYR A -7 REMARK 465 SER A -6 REMARK 465 MET A -5 REMARK 465 GLN A -4 REMARK 465 LEU A -3 REMARK 465 ALA A -2 REMARK 465 SER A -1 REMARK 465 CYS A 0 REMARK 465 VAL A 1 REMARK 465 THR A 2 REMARK 465 LEU A 3 REMARK 465 THR A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 VAL A 9 REMARK 465 ASN A 10 REMARK 465 SER A 11 REMARK 465 GLN A 12 REMARK 465 HIS A 13 REMARK 465 HIS A 14 REMARK 465 HIS A 15 REMARK 465 HIS A 16 REMARK 465 HIS A 17 REMARK 465 HIS A 18 REMARK 465 GLY A 19 REMARK 465 SER A 20 REMARK 465 ALA A 21 REMARK 465 TRP A 22 REMARK 465 SER A 23 REMARK 465 HIS A 24 REMARK 465 PRO A 25 REMARK 465 GLN A 26 REMARK 465 PHE A 27 REMARK 465 GLU A 28 REMARK 465 LYS A 29 REMARK 465 GLY A 30 REMARK 465 GLY A 31 REMARK 465 SER A 32 REMARK 465 SER A 33 REMARK 465 SER A 34 REMARK 465 ASP A 35 REMARK 465 TYR A 36 REMARK 465 SER A 37 REMARK 465 ASP A 38 REMARK 465 LEU A 39 REMARK 465 GLN A 40 REMARK 465 ARG A 41 REMARK 465 VAL A 42 REMARK 465 LYS A 43 REMARK 465 GLN A 44 REMARK 465 GLU A 45 REMARK 465 LEU A 46 REMARK 465 LEU A 47 REMARK 465 GLU A 48 REMARK 465 GLU A 49 REMARK 465 VAL A 50 REMARK 465 LYS A 51 REMARK 465 LYS A 52 REMARK 465 GLU A 53 REMARK 465 LEU A 54 REMARK 465 GLN A 55 REMARK 465 LYS A 56 REMARK 465 VAL A 57 REMARK 465 LYS A 58 REMARK 465 GLU A 59 REMARK 465 GLU A 60 REMARK 465 ILE A 61 REMARK 465 ILE A 62 REMARK 465 GLU A 63 REMARK 465 ALA A 64 REMARK 465 PHE A 65 REMARK 465 VAL A 66 REMARK 465 GLN A 67 REMARK 465 GLU A 68 REMARK 465 LEU A 69 REMARK 465 ARG A 70 REMARK 465 LYS A 71 REMARK 465 ARG A 72 REMARK 465 GLY A 73 REMARK 465 SER A 74 REMARK 465 LEU A 75 REMARK 465 VAL A 76 REMARK 465 PRO A 77 REMARK 465 ARG A 78 REMARK 465 GLY A 79 REMARK 465 SER A 80 REMARK 465 GLY A 81 REMARK 465 GLY A 82 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 MET B -8 REMARK 465 TYR B -7 REMARK 465 SER B -6 REMARK 465 MET B -5 REMARK 465 GLN B -4 REMARK 465 LEU B -3 REMARK 465 ALA B -2 REMARK 465 SER B -1 REMARK 465 CYS B 0 REMARK 465 VAL B 1 REMARK 465 THR B 2 REMARK 465 LEU B 3 REMARK 465 THR B 4 REMARK 465 LEU B 5 REMARK 465 VAL B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 VAL B 9 REMARK 465 ASN B 10 REMARK 465 SER B 11 REMARK 465 GLN B 12 REMARK 465 HIS B 13 REMARK 465 HIS B 14 REMARK 465 HIS B 15 REMARK 465 HIS B 16 REMARK 465 HIS B 17 REMARK 465 HIS B 18 REMARK 465 GLY B 19 REMARK 465 SER B 20 REMARK 465 ALA B 21 REMARK 465 TRP B 22 REMARK 465 SER B 23 REMARK 465 HIS B 24 REMARK 465 PRO B 25 REMARK 465 GLN B 26 REMARK 465 PHE B 27 REMARK 465 GLU B 28 REMARK 465 LYS B 29 REMARK 465 GLY B 30 REMARK 465 GLY B 31 REMARK 465 SER B 32 REMARK 465 SER B 33 REMARK 465 SER B 34 REMARK 465 ASP B 35 REMARK 465 TYR B 36 REMARK 465 SER B 37 REMARK 465 ASP B 38 REMARK 465 LEU B 39 REMARK 465 GLN B 40 REMARK 465 ARG B 41 REMARK 465 VAL B 42 REMARK 465 LYS B 43 REMARK 465 GLN B 44 REMARK 465 GLU B 45 REMARK 465 LEU B 46 REMARK 465 LEU B 47 REMARK 465 GLU B 48 REMARK 465 GLU B 49 REMARK 465 VAL B 50 REMARK 465 LYS B 51 REMARK 465 LYS B 52 REMARK 465 GLU B 53 REMARK 465 LEU B 54 REMARK 465 GLN B 55 REMARK 465 LYS B 56 REMARK 465 VAL B 57 REMARK 465 LYS B 58 REMARK 465 GLU B 59 REMARK 465 GLU B 60 REMARK 465 ILE B 61 REMARK 465 ILE B 62 REMARK 465 GLU B 63 REMARK 465 ALA B 64 REMARK 465 PHE B 65 REMARK 465 VAL B 66 REMARK 465 GLN B 67 REMARK 465 GLU B 68 REMARK 465 LEU B 69 REMARK 465 ARG B 70 REMARK 465 LYS B 71 REMARK 465 ARG B 72 REMARK 465 GLY B 73 REMARK 465 SER B 74 REMARK 465 LEU B 75 REMARK 465 VAL B 76 REMARK 465 PRO B 77 REMARK 465 ARG B 78 REMARK 465 GLY B 79 REMARK 465 SER B 80 REMARK 465 GLY B 81 REMARK 465 GLY B 82 REMARK 465 ALA E 114 REMARK 465 SER E 115 REMARK 465 THR E 116 REMARK 465 LYS E 117 REMARK 465 GLY E 118 REMARK 465 PRO E 119 REMARK 465 SER E 120 REMARK 465 VAL E 121 REMARK 465 PHE E 122 REMARK 465 PRO E 123 REMARK 465 LEU E 124 REMARK 465 ALA E 125 REMARK 465 PRO E 126 REMARK 465 SER E 127 REMARK 465 SER E 128 REMARK 465 LYS E 129 REMARK 465 SER E 130 REMARK 465 THR E 131 REMARK 465 SER E 132 REMARK 465 GLY E 133 REMARK 465 GLY E 134 REMARK 465 THR E 135 REMARK 465 ALA E 136 REMARK 465 ALA E 137 REMARK 465 LEU E 138 REMARK 465 GLY E 139 REMARK 465 CYS E 140 REMARK 465 LEU E 141 REMARK 465 VAL E 142 REMARK 465 LYS E 143 REMARK 465 ASP E 144 REMARK 465 TYR E 145 REMARK 465 PHE E 146 REMARK 465 PRO E 147 REMARK 465 GLU E 148 REMARK 465 PRO E 149 REMARK 465 VAL E 150 REMARK 465 THR E 151 REMARK 465 VAL E 152 REMARK 465 SER E 153 REMARK 465 TRP E 154 REMARK 465 ASN E 155 REMARK 465 SER E 156 REMARK 465 GLY E 157 REMARK 465 ALA E 158 REMARK 465 LEU E 159 REMARK 465 THR E 160 REMARK 465 SER E 161 REMARK 465 GLY E 162 REMARK 465 VAL E 163 REMARK 465 HIS E 164 REMARK 465 THR E 165 REMARK 465 PHE E 166 REMARK 465 PRO E 167 REMARK 465 ALA E 168 REMARK 465 VAL E 169 REMARK 465 LEU E 170 REMARK 465 GLN E 171 REMARK 465 SER E 172 REMARK 465 SER E 173 REMARK 465 GLY E 174 REMARK 465 LEU E 175 REMARK 465 TYR E 176 REMARK 465 SER E 177 REMARK 465 LEU E 178 REMARK 465 SER E 179 REMARK 465 SER E 180 REMARK 465 VAL E 181 REMARK 465 VAL E 182 REMARK 465 THR E 183 REMARK 465 VAL E 184 REMARK 465 PRO E 185 REMARK 465 SER E 186 REMARK 465 SER E 187 REMARK 465 SER E 188 REMARK 465 LEU E 189 REMARK 465 GLY E 190 REMARK 465 THR E 191 REMARK 465 GLN E 192 REMARK 465 THR E 193 REMARK 465 TYR E 194 REMARK 465 ILE E 195 REMARK 465 CYS E 196 REMARK 465 ASN E 197 REMARK 465 VAL E 198 REMARK 465 ASN E 199 REMARK 465 HIS E 200 REMARK 465 LYS E 201 REMARK 465 PRO E 202 REMARK 465 SER E 203 REMARK 465 ASN E 204 REMARK 465 THR E 205 REMARK 465 LYS E 206 REMARK 465 VAL E 207 REMARK 465 ASP E 208 REMARK 465 LYS E 209 REMARK 465 ARG E 210 REMARK 465 VAL E 211 REMARK 465 GLU E 212 REMARK 465 PRO E 213 REMARK 465 LYS E 214 REMARK 465 SER E 215 REMARK 465 CYS E 216 REMARK 465 ASP E 217 REMARK 465 ARG I 108 REMARK 465 THR I 109 REMARK 465 VAL I 110 REMARK 465 ALA I 111 REMARK 465 ALA I 112 REMARK 465 PRO I 113 REMARK 465 SER I 114 REMARK 465 VAL I 115 REMARK 465 PHE I 116 REMARK 465 ILE I 117 REMARK 465 PHE I 118 REMARK 465 PRO I 119 REMARK 465 PRO I 120 REMARK 465 SER I 121 REMARK 465 ASP I 122 REMARK 465 GLU I 123 REMARK 465 GLN I 124 REMARK 465 LEU I 125 REMARK 465 LYS I 126 REMARK 465 SER I 127 REMARK 465 GLY I 128 REMARK 465 THR I 129 REMARK 465 ALA I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 VAL I 133 REMARK 465 CYS I 134 REMARK 465 LEU I 135 REMARK 465 LEU I 136 REMARK 465 ASN I 137 REMARK 465 ASN I 138 REMARK 465 PHE I 139 REMARK 465 TYR I 140 REMARK 465 PRO I 141 REMARK 465 ARG I 142 REMARK 465 GLU I 143 REMARK 465 ALA I 144 REMARK 465 LYS I 145 REMARK 465 VAL I 146 REMARK 465 GLN I 147 REMARK 465 TRP I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 ASP I 151 REMARK 465 ASN I 152 REMARK 465 ALA I 153 REMARK 465 LEU I 154 REMARK 465 GLN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLN I 160 REMARK 465 GLU I 161 REMARK 465 SER I 162 REMARK 465 VAL I 163 REMARK 465 THR I 164 REMARK 465 GLU I 165 REMARK 465 GLN I 166 REMARK 465 ASP I 167 REMARK 465 SER I 168 REMARK 465 LYS I 169 REMARK 465 ASP I 170 REMARK 465 SER I 171 REMARK 465 THR I 172 REMARK 465 TYR I 173 REMARK 465 SER I 174 REMARK 465 LEU I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 THR I 178 REMARK 465 LEU I 179 REMARK 465 THR I 180 REMARK 465 LEU I 181 REMARK 465 SER I 182 REMARK 465 LYS I 183 REMARK 465 ALA I 184 REMARK 465 ASP I 185 REMARK 465 TYR I 186 REMARK 465 GLU I 187 REMARK 465 LYS I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 VAL I 191 REMARK 465 TYR I 192 REMARK 465 ALA I 193 REMARK 465 CYS I 194 REMARK 465 GLU I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLN I 199 REMARK 465 GLY I 200 REMARK 465 LEU I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 PRO I 204 REMARK 465 VAL I 205 REMARK 465 THR I 206 REMARK 465 LYS I 207 REMARK 465 SER I 208 REMARK 465 PHE I 209 REMARK 465 ASN I 210 REMARK 465 ARG I 211 REMARK 465 GLY I 212 REMARK 465 GLU I 213 REMARK 465 CYS I 214 REMARK 465 MET C -8 REMARK 465 TYR C -7 REMARK 465 SER C -6 REMARK 465 MET C -5 REMARK 465 GLN C -4 REMARK 465 LEU C -3 REMARK 465 ALA C -2 REMARK 465 SER C -1 REMARK 465 CYS C 0 REMARK 465 VAL C 1 REMARK 465 THR C 2 REMARK 465 LEU C 3 REMARK 465 THR C 4 REMARK 465 LEU C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 VAL C 9 REMARK 465 ASN C 10 REMARK 465 SER C 11 REMARK 465 GLN C 12 REMARK 465 HIS C 13 REMARK 465 HIS C 14 REMARK 465 HIS C 15 REMARK 465 HIS C 16 REMARK 465 HIS C 17 REMARK 465 HIS C 18 REMARK 465 GLY C 19 REMARK 465 SER C 20 REMARK 465 ALA C 21 REMARK 465 TRP C 22 REMARK 465 SER C 23 REMARK 465 HIS C 24 REMARK 465 PRO C 25 REMARK 465 GLN C 26 REMARK 465 PHE C 27 REMARK 465 GLU C 28 REMARK 465 LYS C 29 REMARK 465 GLY C 30 REMARK 465 GLY C 31 REMARK 465 SER C 32 REMARK 465 SER C 33 REMARK 465 SER C 34 REMARK 465 ASP C 35 REMARK 465 TYR C 36 REMARK 465 SER C 37 REMARK 465 ASP C 38 REMARK 465 LEU C 39 REMARK 465 GLN C 40 REMARK 465 ARG C 41 REMARK 465 VAL C 42 REMARK 465 LYS C 43 REMARK 465 GLN C 44 REMARK 465 GLU C 45 REMARK 465 LEU C 46 REMARK 465 LEU C 47 REMARK 465 GLU C 48 REMARK 465 GLU C 49 REMARK 465 VAL C 50 REMARK 465 LYS C 51 REMARK 465 LYS C 52 REMARK 465 GLU C 53 REMARK 465 LEU C 54 REMARK 465 GLN C 55 REMARK 465 LYS C 56 REMARK 465 VAL C 57 REMARK 465 LYS C 58 REMARK 465 GLU C 59 REMARK 465 GLU C 60 REMARK 465 ILE C 61 REMARK 465 ILE C 62 REMARK 465 GLU C 63 REMARK 465 ALA C 64 REMARK 465 PHE C 65 REMARK 465 VAL C 66 REMARK 465 GLN C 67 REMARK 465 GLU C 68 REMARK 465 LEU C 69 REMARK 465 ARG C 70 REMARK 465 LYS C 71 REMARK 465 ARG C 72 REMARK 465 GLY C 73 REMARK 465 SER C 74 REMARK 465 LEU C 75 REMARK 465 VAL C 76 REMARK 465 PRO C 77 REMARK 465 ARG C 78 REMARK 465 GLY C 79 REMARK 465 SER C 80 REMARK 465 GLY C 81 REMARK 465 GLY C 82 REMARK 465 ALA F 114 REMARK 465 SER F 115 REMARK 465 THR F 116 REMARK 465 LYS F 117 REMARK 465 GLY F 118 REMARK 465 PRO F 119 REMARK 465 SER F 120 REMARK 465 VAL F 121 REMARK 465 PHE F 122 REMARK 465 PRO F 123 REMARK 465 LEU F 124 REMARK 465 ALA F 125 REMARK 465 PRO F 126 REMARK 465 SER F 127 REMARK 465 SER F 128 REMARK 465 LYS F 129 REMARK 465 SER F 130 REMARK 465 THR F 131 REMARK 465 SER F 132 REMARK 465 GLY F 133 REMARK 465 GLY F 134 REMARK 465 THR F 135 REMARK 465 ALA F 136 REMARK 465 ALA F 137 REMARK 465 LEU F 138 REMARK 465 GLY F 139 REMARK 465 CYS F 140 REMARK 465 LEU F 141 REMARK 465 VAL F 142 REMARK 465 LYS F 143 REMARK 465 ASP F 144 REMARK 465 TYR F 145 REMARK 465 PHE F 146 REMARK 465 PRO F 147 REMARK 465 GLU F 148 REMARK 465 PRO F 149 REMARK 465 VAL F 150 REMARK 465 THR F 151 REMARK 465 VAL F 152 REMARK 465 SER F 153 REMARK 465 TRP F 154 REMARK 465 ASN F 155 REMARK 465 SER F 156 REMARK 465 GLY F 157 REMARK 465 ALA F 158 REMARK 465 LEU F 159 REMARK 465 THR F 160 REMARK 465 SER F 161 REMARK 465 GLY F 162 REMARK 465 VAL F 163 REMARK 465 HIS F 164 REMARK 465 THR F 165 REMARK 465 PHE F 166 REMARK 465 PRO F 167 REMARK 465 ALA F 168 REMARK 465 VAL F 169 REMARK 465 LEU F 170 REMARK 465 GLN F 171 REMARK 465 SER F 172 REMARK 465 SER F 173 REMARK 465 GLY F 174 REMARK 465 LEU F 175 REMARK 465 TYR F 176 REMARK 465 SER F 177 REMARK 465 LEU F 178 REMARK 465 SER F 179 REMARK 465 SER F 180 REMARK 465 VAL F 181 REMARK 465 VAL F 182 REMARK 465 THR F 183 REMARK 465 VAL F 184 REMARK 465 PRO F 185 REMARK 465 SER F 186 REMARK 465 SER F 187 REMARK 465 SER F 188 REMARK 465 LEU F 189 REMARK 465 GLY F 190 REMARK 465 THR F 191 REMARK 465 GLN F 192 REMARK 465 THR F 193 REMARK 465 TYR F 194 REMARK 465 ILE F 195 REMARK 465 CYS F 196 REMARK 465 ASN F 197 REMARK 465 VAL F 198 REMARK 465 ASN F 199 REMARK 465 HIS F 200 REMARK 465 LYS F 201 REMARK 465 PRO F 202 REMARK 465 SER F 203 REMARK 465 ASN F 204 REMARK 465 THR F 205 REMARK 465 LYS F 206 REMARK 465 VAL F 207 REMARK 465 ASP F 208 REMARK 465 LYS F 209 REMARK 465 ARG F 210 REMARK 465 VAL F 211 REMARK 465 GLU F 212 REMARK 465 PRO F 213 REMARK 465 LYS F 214 REMARK 465 SER F 215 REMARK 465 CYS F 216 REMARK 465 ASP F 217 REMARK 465 ARG J 108 REMARK 465 THR J 109 REMARK 465 VAL J 110 REMARK 465 ALA J 111 REMARK 465 ALA J 112 REMARK 465 PRO J 113 REMARK 465 SER J 114 REMARK 465 VAL J 115 REMARK 465 PHE J 116 REMARK 465 ILE J 117 REMARK 465 PHE J 118 REMARK 465 PRO J 119 REMARK 465 PRO J 120 REMARK 465 SER J 121 REMARK 465 ASP J 122 REMARK 465 GLU J 123 REMARK 465 GLN J 124 REMARK 465 LEU J 125 REMARK 465 LYS J 126 REMARK 465 SER J 127 REMARK 465 GLY J 128 REMARK 465 THR J 129 REMARK 465 ALA J 130 REMARK 465 SER J 131 REMARK 465 VAL J 132 REMARK 465 VAL J 133 REMARK 465 CYS J 134 REMARK 465 LEU J 135 REMARK 465 LEU J 136 REMARK 465 ASN J 137 REMARK 465 ASN J 138 REMARK 465 PHE J 139 REMARK 465 TYR J 140 REMARK 465 PRO J 141 REMARK 465 ARG J 142 REMARK 465 GLU J 143 REMARK 465 ALA J 144 REMARK 465 LYS J 145 REMARK 465 VAL J 146 REMARK 465 GLN J 147 REMARK 465 TRP J 148 REMARK 465 LYS J 149 REMARK 465 VAL J 150 REMARK 465 ASP J 151 REMARK 465 ASN J 152 REMARK 465 ALA J 153 REMARK 465 LEU J 154 REMARK 465 GLN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ASN J 158 REMARK 465 SER J 159 REMARK 465 GLN J 160 REMARK 465 GLU J 161 REMARK 465 SER J 162 REMARK 465 VAL J 163 REMARK 465 THR J 164 REMARK 465 GLU J 165 REMARK 465 GLN J 166 REMARK 465 ASP J 167 REMARK 465 SER J 168 REMARK 465 LYS J 169 REMARK 465 ASP J 170 REMARK 465 SER J 171 REMARK 465 THR J 172 REMARK 465 TYR J 173 REMARK 465 SER J 174 REMARK 465 LEU J 175 REMARK 465 SER J 176 REMARK 465 SER J 177 REMARK 465 THR J 178 REMARK 465 LEU J 179 REMARK 465 THR J 180 REMARK 465 LEU J 181 REMARK 465 SER J 182 REMARK 465 LYS J 183 REMARK 465 ALA J 184 REMARK 465 ASP J 185 REMARK 465 TYR J 186 REMARK 465 GLU J 187 REMARK 465 LYS J 188 REMARK 465 HIS J 189 REMARK 465 LYS J 190 REMARK 465 VAL J 191 REMARK 465 TYR J 192 REMARK 465 ALA J 193 REMARK 465 CYS J 194 REMARK 465 GLU J 195 REMARK 465 VAL J 196 REMARK 465 THR J 197 REMARK 465 HIS J 198 REMARK 465 GLN J 199 REMARK 465 GLY J 200 REMARK 465 LEU J 201 REMARK 465 SER J 202 REMARK 465 SER J 203 REMARK 465 PRO J 204 REMARK 465 VAL J 205 REMARK 465 THR J 206 REMARK 465 LYS J 207 REMARK 465 SER J 208 REMARK 465 PHE J 209 REMARK 465 ASN J 210 REMARK 465 ARG J 211 REMARK 465 GLY J 212 REMARK 465 GLU J 213 REMARK 465 CYS J 214 REMARK 465 MET D -8 REMARK 465 TYR D -7 REMARK 465 SER D -6 REMARK 465 MET D -5 REMARK 465 GLN D -4 REMARK 465 LEU D -3 REMARK 465 ALA D -2 REMARK 465 SER D -1 REMARK 465 CYS D 0 REMARK 465 VAL D 1 REMARK 465 THR D 2 REMARK 465 LEU D 3 REMARK 465 THR D 4 REMARK 465 LEU D 5 REMARK 465 VAL D 6 REMARK 465 LEU D 7 REMARK 465 LEU D 8 REMARK 465 VAL D 9 REMARK 465 ASN D 10 REMARK 465 SER D 11 REMARK 465 GLN D 12 REMARK 465 HIS D 13 REMARK 465 HIS D 14 REMARK 465 HIS D 15 REMARK 465 HIS D 16 REMARK 465 HIS D 17 REMARK 465 HIS D 18 REMARK 465 GLY D 19 REMARK 465 SER D 20 REMARK 465 ALA D 21 REMARK 465 TRP D 22 REMARK 465 SER D 23 REMARK 465 HIS D 24 REMARK 465 PRO D 25 REMARK 465 GLN D 26 REMARK 465 PHE D 27 REMARK 465 GLU D 28 REMARK 465 LYS D 29 REMARK 465 GLY D 30 REMARK 465 GLY D 31 REMARK 465 SER D 32 REMARK 465 SER D 33 REMARK 465 SER D 34 REMARK 465 ASP D 35 REMARK 465 TYR D 36 REMARK 465 SER D 37 REMARK 465 ASP D 38 REMARK 465 LEU D 39 REMARK 465 GLN D 40 REMARK 465 ARG D 41 REMARK 465 VAL D 42 REMARK 465 LYS D 43 REMARK 465 GLN D 44 REMARK 465 GLU D 45 REMARK 465 LEU D 46 REMARK 465 LEU D 47 REMARK 465 GLU D 48 REMARK 465 GLU D 49 REMARK 465 VAL D 50 REMARK 465 LYS D 51 REMARK 465 LYS D 52 REMARK 465 GLU D 53 REMARK 465 LEU D 54 REMARK 465 GLN D 55 REMARK 465 LYS D 56 REMARK 465 VAL D 57 REMARK 465 LYS D 58 REMARK 465 GLU D 59 REMARK 465 GLU D 60 REMARK 465 ILE D 61 REMARK 465 ILE D 62 REMARK 465 GLU D 63 REMARK 465 ALA D 64 REMARK 465 PHE D 65 REMARK 465 VAL D 66 REMARK 465 GLN D 67 REMARK 465 GLU D 68 REMARK 465 LEU D 69 REMARK 465 ARG D 70 REMARK 465 LYS D 71 REMARK 465 ARG D 72 REMARK 465 GLY D 73 REMARK 465 SER D 74 REMARK 465 LEU D 75 REMARK 465 VAL D 76 REMARK 465 PRO D 77 REMARK 465 ARG D 78 REMARK 465 GLY D 79 REMARK 465 SER D 80 REMARK 465 GLY D 81 REMARK 465 GLY D 82 REMARK 465 ALA G 114 REMARK 465 SER G 115 REMARK 465 THR G 116 REMARK 465 LYS G 117 REMARK 465 GLY G 118 REMARK 465 PRO G 119 REMARK 465 SER G 120 REMARK 465 VAL G 121 REMARK 465 PHE G 122 REMARK 465 PRO G 123 REMARK 465 LEU G 124 REMARK 465 ALA G 125 REMARK 465 PRO G 126 REMARK 465 SER G 127 REMARK 465 SER G 128 REMARK 465 LYS G 129 REMARK 465 SER G 130 REMARK 465 THR G 131 REMARK 465 SER G 132 REMARK 465 GLY G 133 REMARK 465 GLY G 134 REMARK 465 THR G 135 REMARK 465 ALA G 136 REMARK 465 ALA G 137 REMARK 465 LEU G 138 REMARK 465 GLY G 139 REMARK 465 CYS G 140 REMARK 465 LEU G 141 REMARK 465 VAL G 142 REMARK 465 LYS G 143 REMARK 465 ASP G 144 REMARK 465 TYR G 145 REMARK 465 PHE G 146 REMARK 465 PRO G 147 REMARK 465 GLU G 148 REMARK 465 PRO G 149 REMARK 465 VAL G 150 REMARK 465 THR G 151 REMARK 465 VAL G 152 REMARK 465 SER G 153 REMARK 465 TRP G 154 REMARK 465 ASN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ALA G 158 REMARK 465 LEU G 159 REMARK 465 THR G 160 REMARK 465 SER G 161 REMARK 465 GLY G 162 REMARK 465 VAL G 163 REMARK 465 HIS G 164 REMARK 465 THR G 165 REMARK 465 PHE G 166 REMARK 465 PRO G 167 REMARK 465 ALA G 168 REMARK 465 VAL G 169 REMARK 465 LEU G 170 REMARK 465 GLN G 171 REMARK 465 SER G 172 REMARK 465 SER G 173 REMARK 465 GLY G 174 REMARK 465 LEU G 175 REMARK 465 TYR G 176 REMARK 465 SER G 177 REMARK 465 LEU G 178 REMARK 465 SER G 179 REMARK 465 SER G 180 REMARK 465 VAL G 181 REMARK 465 VAL G 182 REMARK 465 THR G 183 REMARK 465 VAL G 184 REMARK 465 PRO G 185 REMARK 465 SER G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 LEU G 189 REMARK 465 GLY G 190 REMARK 465 THR G 191 REMARK 465 GLN G 192 REMARK 465 THR G 193 REMARK 465 TYR G 194 REMARK 465 ILE G 195 REMARK 465 CYS G 196 REMARK 465 ASN G 197 REMARK 465 VAL G 198 REMARK 465 ASN G 199 REMARK 465 HIS G 200 REMARK 465 LYS G 201 REMARK 465 PRO G 202 REMARK 465 SER G 203 REMARK 465 ASN G 204 REMARK 465 THR G 205 REMARK 465 LYS G 206 REMARK 465 VAL G 207 REMARK 465 ASP G 208 REMARK 465 LYS G 209 REMARK 465 ARG G 210 REMARK 465 VAL G 211 REMARK 465 GLU G 212 REMARK 465 PRO G 213 REMARK 465 LYS G 214 REMARK 465 SER G 215 REMARK 465 CYS G 216 REMARK 465 ASP G 217 REMARK 465 ARG K 108 REMARK 465 THR K 109 REMARK 465 VAL K 110 REMARK 465 ALA K 111 REMARK 465 ALA K 112 REMARK 465 PRO K 113 REMARK 465 SER K 114 REMARK 465 VAL K 115 REMARK 465 PHE K 116 REMARK 465 ILE K 117 REMARK 465 PHE K 118 REMARK 465 PRO K 119 REMARK 465 PRO K 120 REMARK 465 SER K 121 REMARK 465 ASP K 122 REMARK 465 GLU K 123 REMARK 465 GLN K 124 REMARK 465 LEU K 125 REMARK 465 LYS K 126 REMARK 465 SER K 127 REMARK 465 GLY K 128 REMARK 465 THR K 129 REMARK 465 ALA K 130 REMARK 465 SER K 131 REMARK 465 VAL K 132 REMARK 465 VAL K 133 REMARK 465 CYS K 134 REMARK 465 LEU K 135 REMARK 465 LEU K 136 REMARK 465 ASN K 137 REMARK 465 ASN K 138 REMARK 465 PHE K 139 REMARK 465 TYR K 140 REMARK 465 PRO K 141 REMARK 465 ARG K 142 REMARK 465 GLU K 143 REMARK 465 ALA K 144 REMARK 465 LYS K 145 REMARK 465 VAL K 146 REMARK 465 GLN K 147 REMARK 465 TRP K 148 REMARK 465 LYS K 149 REMARK 465 VAL K 150 REMARK 465 ASP K 151 REMARK 465 ASN K 152 REMARK 465 ALA K 153 REMARK 465 LEU K 154 REMARK 465 GLN K 155 REMARK 465 SER K 156 REMARK 465 GLY K 157 REMARK 465 ASN K 158 REMARK 465 SER K 159 REMARK 465 GLN K 160 REMARK 465 GLU K 161 REMARK 465 SER K 162 REMARK 465 VAL K 163 REMARK 465 THR K 164 REMARK 465 GLU K 165 REMARK 465 GLN K 166 REMARK 465 ASP K 167 REMARK 465 SER K 168 REMARK 465 LYS K 169 REMARK 465 ASP K 170 REMARK 465 SER K 171 REMARK 465 THR K 172 REMARK 465 TYR K 173 REMARK 465 SER K 174 REMARK 465 LEU K 175 REMARK 465 SER K 176 REMARK 465 SER K 177 REMARK 465 THR K 178 REMARK 465 LEU K 179 REMARK 465 THR K 180 REMARK 465 LEU K 181 REMARK 465 SER K 182 REMARK 465 LYS K 183 REMARK 465 ALA K 184 REMARK 465 ASP K 185 REMARK 465 TYR K 186 REMARK 465 GLU K 187 REMARK 465 LYS K 188 REMARK 465 HIS K 189 REMARK 465 LYS K 190 REMARK 465 VAL K 191 REMARK 465 TYR K 192 REMARK 465 ALA K 193 REMARK 465 CYS K 194 REMARK 465 GLU K 195 REMARK 465 VAL K 196 REMARK 465 THR K 197 REMARK 465 HIS K 198 REMARK 465 GLN K 199 REMARK 465 GLY K 200 REMARK 465 LEU K 201 REMARK 465 SER K 202 REMARK 465 SER K 203 REMARK 465 PRO K 204 REMARK 465 VAL K 205 REMARK 465 THR K 206 REMARK 465 LYS K 207 REMARK 465 SER K 208 REMARK 465 PHE K 209 REMARK 465 ASN K 210 REMARK 465 ARG K 211 REMARK 465 GLY K 212 REMARK 465 GLU K 213 REMARK 465 CYS K 214 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS A 470 CG CD CE NZ REMARK 470 LYS B 470 CG CD CE NZ REMARK 470 LYS C 470 CG CD CE NZ REMARK 470 LYS D 470 CG CD CE NZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LYS A 102 119.06 -160.13 REMARK 500 ASN A 170 11.14 -140.22 REMARK 500 ILE A 187 -58.67 -123.49 REMARK 500 THR A 225 -164.77 -129.33 REMARK 500 CYS A 291 -169.70 -124.31 REMARK 500 TRP A 295 -62.87 -100.22 REMARK 500 HIS A 296 31.60 -146.39 REMARK 500 ASN A 347 -179.71 66.48 REMARK 500 SER A 404 -169.78 -104.58 REMARK 500 ILE H 48 -62.68 -97.67 REMARK 500 ALA L 51 -11.57 73.38 REMARK 500 LYS B 102 119.10 -160.20 REMARK 500 ASN B 170 11.14 -140.22 REMARK 500 ILE B 187 -58.67 -123.43 REMARK 500 THR B 225 -164.80 -129.32 REMARK 500 CYS B 291 -169.70 -124.31 REMARK 500 TRP B 295 -62.88 -100.21 REMARK 500 HIS B 296 31.60 -146.39 REMARK 500 ASN B 347 -179.71 66.48 REMARK 500 SER B 404 -169.78 -104.58 REMARK 500 ILE E 48 -62.68 -97.67 REMARK 500 ALA I 51 -11.49 73.34 REMARK 500 LYS C 102 119.04 -160.20 REMARK 500 ASN C 170 11.14 -140.26 REMARK 500 ILE C 187 -58.65 -123.43 REMARK 500 THR C 225 -164.76 -129.30 REMARK 500 CYS C 291 -169.70 -124.31 REMARK 500 TRP C 295 -62.88 -100.21 REMARK 500 HIS C 296 31.60 -146.39 REMARK 500 ASN C 347 -179.71 66.47 REMARK 500 SER C 404 -169.78 -104.58 REMARK 500 ILE F 48 -62.63 -97.67 REMARK 500 ALA J 51 -11.49 73.34 REMARK 500 LYS D 102 119.04 -160.20 REMARK 500 ASN D 170 11.14 -140.26 REMARK 500 ILE D 187 -58.67 -123.42 REMARK 500 THR D 225 -164.79 -129.32 REMARK 500 CYS D 291 -169.70 -124.31 REMARK 500 TRP D 295 -62.88 -100.21 REMARK 500 HIS D 296 31.60 -146.39 REMARK 500 ASN D 347 -179.71 66.47 REMARK 500 SER D 404 -169.78 -104.62 REMARK 500 ILE G 48 -62.61 -97.74 REMARK 500 ALA K 51 -11.56 73.38 REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA A 505 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP A 293 O REMARK 620 2 GLY A 297 O 79.9 REMARK 620 3 ASP A 324 OD2 82.8 88.6 REMARK 620 4 GLY A 345 O 87.0 90.9 169.7 REMARK 620 5 ASN A 347 O 87.5 167.3 87.7 90.6 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA A 506 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP A 379 OD1 REMARK 620 2 ASN A 381 OD1 86.1 REMARK 620 3 ASP A 387 OD2 161.5 94.8 REMARK 620 4 ASN A 389 O 68.3 120.1 95.6 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA B 504 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP B 293 O REMARK 620 2 GLY B 297 O 79.9 REMARK 620 3 ASP B 324 OD2 82.8 88.6 REMARK 620 4 GLY B 345 O 87.0 90.9 169.7 REMARK 620 5 ASN B 347 O 87.5 167.3 87.7 90.6 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA B 505 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP B 379 OD1 REMARK 620 2 ASN B 381 OD1 86.1 REMARK 620 3 ASP B 387 OD2 161.5 94.9 REMARK 620 4 ASN B 389 O 68.3 120.1 95.6 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA C 504 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP C 293 O REMARK 620 2 GLY C 297 O 79.9 REMARK 620 3 ASP C 324 OD2 82.8 88.6 REMARK 620 4 GLY C 345 O 87.0 90.9 169.7 REMARK 620 5 ASN C 347 O 87.5 167.3 87.7 90.6 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA C 505 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP C 379 OD1 REMARK 620 2 ASN C 381 OD1 86.0 REMARK 620 3 ASP C 387 OD2 161.5 94.9 REMARK 620 4 ASN C 389 O 68.3 120.1 95.6 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA D 504 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP D 293 O REMARK 620 2 GLY D 297 O 79.9 REMARK 620 3 ASP D 324 OD2 82.8 88.6 REMARK 620 4 GLY D 345 O 87.0 90.9 169.7 REMARK 620 5 ASN D 347 O 87.5 167.3 87.7 90.6 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA D 505 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP D 379 OD1 REMARK 620 2 ASN D 381 OD1 86.0 REMARK 620 3 ASP D 387 OD2 161.6 94.9 REMARK 620 4 ASN D 389 O 68.3 120.1 95.6 REMARK 620 N 1 2 3 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-46041 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF DA03E17 FAB IN COMPLEX WITH INFLUENZA VIRUS REMARK 900 NEURAMINIDASE FROM A/CALIFORNIA/07/2009 (H1N1) DBREF 9CYE A 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9CYE H 1 217 PDB 9CYE 9CYE 1 217 DBREF 9CYE L 1 214 PDB 9CYE 9CYE 1 214 DBREF 9CYE B 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9CYE E 1 217 PDB 9CYE 9CYE 1 217 DBREF 9CYE I 1 214 PDB 9CYE 9CYE 1 214 DBREF 9CYE C 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9CYE F 1 217 PDB 9CYE 9CYE 1 217 DBREF 9CYE J 1 214 PDB 9CYE 9CYE 1 214 DBREF 9CYE D 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9CYE G 1 217 PDB 9CYE 9CYE 1 217 DBREF 9CYE K 1 214 PDB 9CYE 9CYE 1 214 SEQADV 9CYE MET A -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9CYE TYR A -7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A -6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE MET A -5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN A -4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A -3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA A -2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A -1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE CYS A 0 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR A 2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR A 4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 8 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 9 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASN A 10 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 11 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN A 12 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS A 13 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS A 14 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS A 15 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS A 16 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS A 17 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS A 18 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY A 19 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 20 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA A 21 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TRP A 22 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 23 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS A 24 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO A 25 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN A 26 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE A 27 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 28 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS A 29 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY A 30 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY A 31 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 32 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 33 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 34 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP A 35 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TYR A 36 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 37 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP A 38 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 39 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN A 40 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG A 41 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 42 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS A 43 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN A 44 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 45 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 46 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 47 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 48 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 49 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 50 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS A 51 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS A 52 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 53 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 54 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN A 55 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS A 56 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 57 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS A 58 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 59 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 60 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE A 61 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE A 62 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 63 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA A 64 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE A 65 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 66 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN A 67 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU A 68 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 69 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG A 70 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS A 71 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG A 72 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY A 73 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 74 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU A 75 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL A 76 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO A 77 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG A 78 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY A 79 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER A 80 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY A 81 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY A 82 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO A 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9CYE LEU A 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9CYE VAL A 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9CYE SER A 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9CYE ALA A 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9CYE ILE A 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9CYE THR A 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9CYE ILE A 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9CYE PHE A 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9CYE MET A 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9CYE VAL A 419 UNP C7FH46 ARG 419 CONFLICT SEQADV 9CYE MET B -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9CYE TYR B -7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B -6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE MET B -5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN B -4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B -3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA B -2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B -1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE CYS B 0 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR B 2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR B 4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 8 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 9 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASN B 10 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 11 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN B 12 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS B 13 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS B 14 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS B 15 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS B 16 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS B 17 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS B 18 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY B 19 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 20 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA B 21 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TRP B 22 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 23 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS B 24 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO B 25 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN B 26 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE B 27 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 28 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS B 29 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY B 30 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY B 31 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 32 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 33 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 34 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP B 35 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TYR B 36 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 37 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP B 38 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 39 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN B 40 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG B 41 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 42 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS B 43 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN B 44 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 45 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 46 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 47 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 48 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 49 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 50 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS B 51 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS B 52 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 53 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 54 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN B 55 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS B 56 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 57 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS B 58 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 59 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 60 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE B 61 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE B 62 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 63 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA B 64 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE B 65 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 66 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN B 67 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU B 68 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 69 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG B 70 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS B 71 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG B 72 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY B 73 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 74 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU B 75 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL B 76 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO B 77 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG B 78 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY B 79 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER B 80 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY B 81 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY B 82 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO B 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9CYE LEU B 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9CYE VAL B 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9CYE SER B 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9CYE ALA B 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9CYE ILE B 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9CYE THR B 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9CYE ILE B 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9CYE PHE B 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9CYE MET B 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9CYE VAL B 419 UNP C7FH46 ARG 419 CONFLICT SEQADV 9CYE MET C -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9CYE TYR C -7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C -6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE MET C -5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN C -4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C -3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA C -2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C -1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE CYS C 0 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR C 2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR C 4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 8 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 9 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASN C 10 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 11 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN C 12 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS C 13 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS C 14 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS C 15 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS C 16 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS C 17 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS C 18 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY C 19 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 20 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA C 21 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TRP C 22 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 23 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS C 24 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO C 25 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN C 26 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE C 27 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 28 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS C 29 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY C 30 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY C 31 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 32 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 33 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 34 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP C 35 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TYR C 36 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 37 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP C 38 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 39 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN C 40 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG C 41 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 42 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS C 43 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN C 44 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 45 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 46 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 47 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 48 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 49 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 50 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS C 51 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS C 52 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 53 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 54 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN C 55 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS C 56 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 57 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS C 58 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 59 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 60 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE C 61 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE C 62 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 63 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA C 64 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE C 65 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 66 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN C 67 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU C 68 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 69 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG C 70 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS C 71 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG C 72 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY C 73 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 74 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU C 75 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL C 76 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO C 77 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG C 78 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY C 79 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER C 80 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY C 81 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY C 82 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO C 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9CYE LEU C 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9CYE VAL C 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9CYE SER C 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9CYE ALA C 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9CYE ILE C 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9CYE THR C 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9CYE ILE C 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9CYE PHE C 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9CYE MET C 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9CYE VAL C 419 UNP C7FH46 ARG 419 CONFLICT SEQADV 9CYE MET D -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9CYE TYR D -7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D -6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE MET D -5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN D -4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D -3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA D -2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D -1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE CYS D 0 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 1 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR D 2 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 3 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE THR D 4 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 5 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 6 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 7 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 8 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 9 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASN D 10 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 11 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN D 12 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS D 13 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS D 14 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS D 15 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS D 16 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS D 17 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS D 18 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY D 19 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 20 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA D 21 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TRP D 22 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 23 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE HIS D 24 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO D 25 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN D 26 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE D 27 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 28 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS D 29 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY D 30 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY D 31 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 32 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 33 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 34 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP D 35 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE TYR D 36 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 37 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ASP D 38 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 39 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN D 40 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG D 41 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 42 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS D 43 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN D 44 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 45 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 46 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 47 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 48 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 49 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 50 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS D 51 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS D 52 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 53 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 54 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN D 55 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS D 56 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 57 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS D 58 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 59 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 60 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE D 61 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ILE D 62 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 63 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ALA D 64 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PHE D 65 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 66 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLN D 67 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLU D 68 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 69 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG D 70 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LYS D 71 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG D 72 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY D 73 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 74 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE LEU D 75 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE VAL D 76 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO D 77 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE ARG D 78 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY D 79 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE SER D 80 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY D 81 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE GLY D 82 UNP C7FH46 EXPRESSION TAG SEQADV 9CYE PRO D 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9CYE LEU D 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9CYE VAL D 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9CYE SER D 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9CYE ALA D 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9CYE ILE D 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9CYE THR D 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9CYE ILE D 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9CYE PHE D 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9CYE MET D 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9CYE VAL D 419 UNP C7FH46 ARG 419 CONFLICT SEQRES 1 A 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 A 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 A 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 A 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 A 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 A 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 A 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 A 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 A 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 A 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 A 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 A 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 A 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 A 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 A 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 A 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 A 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 A 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 A 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 A 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 A 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 A 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 A 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 A 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 A 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 A 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 A 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 A 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 A 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 A 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 A 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 A 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 A 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 A 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 A 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 A 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 A 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 H 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 H 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 H 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 H 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 H 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 H 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 H 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 H 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 H 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 H 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 H 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 H 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 H 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 H 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 H 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 H 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 H 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 H 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 L 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 L 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 L 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 L 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 L 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 L 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 B 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 B 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 B 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 B 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 B 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 B 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 B 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 B 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 B 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 B 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 B 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 B 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 B 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 B 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 B 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 B 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 B 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 B 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 B 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 B 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 B 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 B 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 B 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 B 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 B 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 B 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 B 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 B 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 B 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 B 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 B 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 B 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 B 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 B 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 B 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 B 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 B 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 E 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 E 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 E 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 E 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 E 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 E 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 E 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 E 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 E 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 E 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 E 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 E 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 E 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 E 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 E 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 E 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 E 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 E 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 I 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 I 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 I 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 I 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 I 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 I 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 I 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 I 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 I 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 I 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 I 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 I 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 I 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 I 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 I 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 I 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 I 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 C 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 C 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 C 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 C 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 C 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 C 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 C 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 C 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 C 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 C 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 C 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 C 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 C 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 C 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 C 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 C 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 C 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 C 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 C 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 C 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 C 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 C 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 C 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 C 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 C 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 C 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 C 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 C 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 C 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 C 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 C 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 C 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 C 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 C 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 C 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 C 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 C 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 F 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 F 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 F 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 F 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 F 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 F 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 F 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 F 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 F 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 F 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 F 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 F 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 F 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 F 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 F 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 F 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 F 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 F 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 J 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 J 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 J 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 J 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 J 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 J 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 J 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 J 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 J 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 J 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 J 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 J 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 J 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 J 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 J 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 J 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 J 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 D 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 D 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 D 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 D 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 D 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 D 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 D 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 D 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 D 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 D 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 D 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 D 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 D 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 D 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 D 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 D 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 D 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 D 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 D 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 D 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 D 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 D 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 D 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 D 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 D 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 D 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 D 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 D 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 D 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 D 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 D 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 D 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 D 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 D 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 D 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 D 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 D 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 G 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 G 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 G 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 G 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 G 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 G 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 G 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 G 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 G 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 G 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 G 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 G 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 G 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 G 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 G 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 G 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 G 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 G 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 K 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 K 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 K 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 K 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 K 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 K 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 K 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 K 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 K 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 K 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 K 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 K 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 K 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 K 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 K 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 K 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 K 215 SER PHE ASN ARG GLY GLU CYS HET NAG A 501 14 HET NAG A 502 14 HET NAG A 503 14 HET CA A 504 1 HET CA A 505 1 HET CA A 506 1 HET NAG B 501 14 HET NAG B 502 14 HET NAG B 503 14 HET CA B 504 1 HET CA B 505 1 HET NAG C 501 14 HET NAG C 502 14 HET NAG C 503 14 HET CA C 504 1 HET CA C 505 1 HET NAG D 501 14 HET NAG D 502 14 HET NAG D 503 14 HET CA D 504 1 HET CA D 505 1 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM CA CALCIUM ION HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 13 NAG 12(C8 H15 N O6) FORMUL 16 CA 9(CA 2+) HELIX 1 AA1 ASN A 104 GLY A 109 1 6 HELIX 2 AA2 ASP A 142 ASN A 146 5 5 HELIX 3 AA3 PRO A 197 GLY A 200 5 4 HELIX 4 AA4 HIS A 412A GLY A 414 1 6 HELIX 5 AA5 LEU H 63 SER H 65 5 3 HELIX 6 AA6 THR H 83 ALA H 87 5 5 HELIX 7 AA7 ALA L 50 SER L 52 5 3 HELIX 8 AA8 GLN L 79 PHE L 83 5 5 HELIX 9 AA9 ASN B 104 GLY B 109 1 6 HELIX 10 AB1 ASP B 142 ASN B 146 5 5 HELIX 11 AB2 PRO B 197 GLY B 200 5 4 HELIX 12 AB3 HIS B 412A GLY B 414 1 6 HELIX 13 AB4 LEU E 63 SER E 65 5 3 HELIX 14 AB5 THR E 83 ALA E 87 5 5 HELIX 15 AB6 ALA I 50 SER I 52 5 3 HELIX 16 AB7 GLN I 79 PHE I 83 5 5 HELIX 17 AB8 ASN C 104 GLY C 109 1 6 HELIX 18 AB9 ASP C 142 ASN C 146 5 5 HELIX 19 AC1 PRO C 197 GLY C 200 5 4 HELIX 20 AC2 HIS C 412A GLY C 414 1 6 HELIX 21 AC3 LEU F 63 SER F 65 5 3 HELIX 22 AC4 THR F 83 ALA F 87 5 5 HELIX 23 AC5 ALA J 50 SER J 52 5 3 HELIX 24 AC6 GLN J 79 PHE J 83 5 5 HELIX 25 AC7 ASN D 104 GLY D 109 1 6 HELIX 26 AC8 ASP D 142 ASN D 146 5 5 HELIX 27 AC9 PRO D 197 GLY D 200 5 4 HELIX 28 AD1 HIS D 412A GLY D 414 1 6 HELIX 29 AD2 LEU G 63 SER G 65 5 3 HELIX 30 AD3 THR G 83 ALA G 87 5 5 HELIX 31 AD4 ALA K 50 SER K 52 5 3 HELIX 32 AD5 GLN K 79 PHE K 83 5 5 SHEET 1 AA1 4 GLY A 96 LYS A 102 0 SHEET 2 AA1 4 THR A 439 VAL A 449 -1 O SER A 445 N LEU A 100 SHEET 3 AA1 4 VAL A 419 GLY A 429 -1 N PRO A 420 O GLY A 448 SHEET 4 AA1 4 SER A 407 MET A 412 -1 N MET A 412 O VAL A 419 SHEET 1 AA2 4 PHE A 115 CYS A 124 0 SHEET 2 AA2 4 CYS A 129 LEU A 139 -1 O PHE A 132 N PHE A 121 SHEET 3 AA2 4 THR A 157 PRO A 162 -1 O MET A 159 N PHE A 133 SHEET 4 AA2 4 ARG A 172 ILE A 176 -1 O ARG A 172 N SER A 160 SHEET 1 AA3 4 SER A 179 HIS A 184 0 SHEET 2 AA3 4 TRP A 189 THR A 195 -1 O LEU A 190 N CYS A 183 SHEET 3 AA3 4 VAL A 202 TYR A 207 -1 O LYS A 206 N THR A 191 SHEET 4 AA3 4 ILE A 210 LYS A 216 -1 O ILE A 215 N ALA A 203 SHEET 1 AA4 3 LEU A 223 ARG A 224 0 SHEET 2 AA4 3 SER A 236 ASP A 243 -1 O THR A 242 N ARG A 224 SHEET 3 AA4 3 ALA A 231 VAL A 233 -1 N VAL A 233 O SER A 236 SHEET 1 AA5 4 LEU A 223 ARG A 224 0 SHEET 2 AA5 4 SER A 236 ASP A 243 -1 O THR A 242 N ARG A 224 SHEET 3 AA5 4 SER A 251 GLU A 258 -1 O PHE A 255 N THR A 239 SHEET 4 AA5 4 LYS A 261 GLU A 267 -1 O LYS A 264 N ARG A 256 SHEET 1 AA6 4 SER A 279 PRO A 282 0 SHEET 2 AA6 4 ILE A 287 VAL A 290 -1 O VAL A 290 N SER A 279 SHEET 3 AA6 4 PRO A 301 PHE A 305 -1 O PHE A 305 N ILE A 287 SHEET 4 AA6 4 TYR A 312 TYR A 316 -1 O GLY A 315 N TRP A 302 SHEET 1 AA7 4 PHE A 352 TYR A 356 0 SHEET 2 AA7 4 GLY A 359 ARG A 364 -1 O GLY A 359 N TYR A 356 SHEET 3 AA7 4 ASN A 372 ASP A 379 -1 O ILE A 377 N ILE A 362 SHEET 4 AA7 4 ILE A 392 TRP A 403 -1 O GLN A 395 N MET A 376 SHEET 1 AA8 4 GLN H 3 SER H 7 0 SHEET 2 AA8 4 LEU H 18 SER H 25 -1 O THR H 21 N SER H 7 SHEET 3 AA8 4 GLN H 77 LEU H 82 -1 O LEU H 82 N LEU H 18 SHEET 4 AA8 4 ALA H 67 ASP H 72 -1 N SER H 70 O SER H 79 SHEET 1 AA9 6 LEU H 11 VAL H 12 0 SHEET 2 AA9 6 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AA9 6 ALA H 88 GLY H 97 -1 N TYR H 90 O THR H 107 SHEET 4 AA9 6 LEU H 35 GLN H 39 -1 N LEU H 35 O VAL H 95 SHEET 5 AA9 6 GLU H 46 ILE H 51 -1 O GLU H 46 N ARG H 38 SHEET 6 AA9 6 TYR H 58 TYR H 59 -1 O TYR H 58 N TYR H 50 SHEET 1 AB1 4 LEU H 11 VAL H 12 0 SHEET 2 AB1 4 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB1 4 ALA H 88 GLY H 97 -1 N TYR H 90 O THR H 107 SHEET 4 AB1 4 PHE H 100F TRP H 103 -1 O TYR H 100G N ASP H 96 SHEET 1 AB2 4 MET L 4 SER L 7 0 SHEET 2 AB2 4 VAL L 19 ALA L 25 -1 O THR L 22 N SER L 7 SHEET 3 AB2 4 ASP L 70 ILE L 75 -1 O PHE L 71 N CYS L 23 SHEET 4 AB2 4 PHE L 62 SER L 65 -1 N SER L 63 O THR L 74 SHEET 1 AB3 2 SER L 10 SER L 12 0 SHEET 2 AB3 2 LYS L 103 ASP L 105 1 O LYS L 103 N VAL L 11 SHEET 1 AB4 5 SER L 53 LEU L 54 0 SHEET 2 AB4 5 PRO L 44 TYR L 49 -1 N TYR L 49 O SER L 53 SHEET 3 AB4 5 LEU L 33 GLN L 38 -1 N TRP L 35 O LEU L 47 SHEET 4 AB4 5 THR L 85 GLN L 90 -1 O THR L 85 N GLN L 38 SHEET 5 AB4 5 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AB5 4 GLY B 96 LYS B 102 0 SHEET 2 AB5 4 THR B 439 VAL B 449 -1 O SER B 445 N LEU B 100 SHEET 3 AB5 4 VAL B 419 GLY B 429 -1 N PRO B 420 O GLY B 448 SHEET 4 AB5 4 SER B 407 MET B 412 -1 N MET B 412 O VAL B 419 SHEET 1 AB6 4 PHE B 115 CYS B 124 0 SHEET 2 AB6 4 CYS B 129 LEU B 139 -1 O PHE B 132 N PHE B 121 SHEET 3 AB6 4 THR B 157 PRO B 162 -1 O MET B 159 N PHE B 133 SHEET 4 AB6 4 ARG B 172 ILE B 176 -1 O ARG B 172 N SER B 160 SHEET 1 AB7 4 SER B 179 HIS B 184 0 SHEET 2 AB7 4 TRP B 189 THR B 195 -1 O LEU B 190 N CYS B 183 SHEET 3 AB7 4 VAL B 202 TYR B 207 -1 O LYS B 206 N THR B 191 SHEET 4 AB7 4 ILE B 210 LYS B 216 -1 O ILE B 215 N ALA B 203 SHEET 1 AB8 3 LEU B 223 ARG B 224 0 SHEET 2 AB8 3 SER B 236 ASP B 243 -1 O THR B 242 N ARG B 224 SHEET 3 AB8 3 ALA B 231 VAL B 233 -1 N VAL B 233 O SER B 236 SHEET 1 AB9 4 LEU B 223 ARG B 224 0 SHEET 2 AB9 4 SER B 236 ASP B 243 -1 O THR B 242 N ARG B 224 SHEET 3 AB9 4 SER B 251 GLU B 258 -1 O PHE B 255 N THR B 239 SHEET 4 AB9 4 LYS B 261 GLU B 267 -1 O LYS B 264 N ARG B 256 SHEET 1 AC1 4 SER B 279 PRO B 282 0 SHEET 2 AC1 4 ILE B 287 VAL B 290 -1 O VAL B 290 N SER B 279 SHEET 3 AC1 4 PRO B 301 PHE B 305 -1 O PHE B 305 N ILE B 287 SHEET 4 AC1 4 TYR B 312 TYR B 316 -1 O GLY B 315 N TRP B 302 SHEET 1 AC2 4 PHE B 352 TYR B 356 0 SHEET 2 AC2 4 GLY B 359 ARG B 364 -1 O GLY B 359 N TYR B 356 SHEET 3 AC2 4 ASN B 372 ASP B 379 -1 O ILE B 377 N ILE B 362 SHEET 4 AC2 4 ILE B 392 TRP B 403 -1 O GLN B 395 N MET B 376 SHEET 1 AC3 4 GLN E 3 SER E 7 0 SHEET 2 AC3 4 LEU E 18 SER E 25 -1 O THR E 21 N SER E 7 SHEET 3 AC3 4 GLN E 77 LEU E 82 -1 O LEU E 82 N LEU E 18 SHEET 4 AC3 4 ALA E 67 ASP E 72 -1 N SER E 70 O SER E 79 SHEET 1 AC4 6 LEU E 11 VAL E 12 0 SHEET 2 AC4 6 THR E 107 VAL E 111 1 O THR E 110 N VAL E 12 SHEET 3 AC4 6 ALA E 88 GLY E 97 -1 N TYR E 90 O THR E 107 SHEET 4 AC4 6 LEU E 35 GLN E 39 -1 N LEU E 35 O VAL E 95 SHEET 5 AC4 6 GLU E 46 ILE E 51 -1 O GLU E 46 N ARG E 38 SHEET 6 AC4 6 TYR E 58 TYR E 59 -1 O TYR E 58 N TYR E 50 SHEET 1 AC5 4 LEU E 11 VAL E 12 0 SHEET 2 AC5 4 THR E 107 VAL E 111 1 O THR E 110 N VAL E 12 SHEET 3 AC5 4 ALA E 88 GLY E 97 -1 N TYR E 90 O THR E 107 SHEET 4 AC5 4 PHE E 100F TRP E 103 -1 O TYR E 100G N ASP E 96 SHEET 1 AC6 4 MET I 4 SER I 7 0 SHEET 2 AC6 4 VAL I 19 ALA I 25 -1 O THR I 22 N SER I 7 SHEET 3 AC6 4 ASP I 70 ILE I 75 -1 O PHE I 71 N CYS I 23 SHEET 4 AC6 4 PHE I 62 SER I 65 -1 N SER I 63 O THR I 74 SHEET 1 AC7 2 SER I 10 SER I 12 0 SHEET 2 AC7 2 LYS I 103 ASP I 105 1 O LYS I 103 N VAL I 11 SHEET 1 AC8 5 SER I 53 LEU I 54 0 SHEET 2 AC8 5 PRO I 44 TYR I 49 -1 N TYR I 49 O SER I 53 SHEET 3 AC8 5 LEU I 33 GLN I 38 -1 N TRP I 35 O LEU I 47 SHEET 4 AC8 5 THR I 85 GLN I 90 -1 O THR I 85 N GLN I 38 SHEET 5 AC8 5 THR I 97 PHE I 98 -1 O THR I 97 N GLN I 90 SHEET 1 AC9 4 GLY C 96 LYS C 102 0 SHEET 2 AC9 4 THR C 439 VAL C 449 -1 O SER C 445 N LEU C 100 SHEET 3 AC9 4 VAL C 419 GLY C 429 -1 N PRO C 420 O GLY C 448 SHEET 4 AC9 4 SER C 407 MET C 412 -1 N MET C 412 O VAL C 419 SHEET 1 AD1 4 PHE C 115 CYS C 124 0 SHEET 2 AD1 4 CYS C 129 LEU C 139 -1 O PHE C 132 N PHE C 121 SHEET 3 AD1 4 THR C 157 PRO C 162 -1 O MET C 159 N PHE C 133 SHEET 4 AD1 4 ARG C 172 ILE C 176 -1 O ARG C 172 N SER C 160 SHEET 1 AD2 4 SER C 179 HIS C 184 0 SHEET 2 AD2 4 TRP C 189 THR C 195 -1 O LEU C 190 N CYS C 183 SHEET 3 AD2 4 VAL C 202 TYR C 207 -1 O LYS C 206 N THR C 191 SHEET 4 AD2 4 ILE C 210 LYS C 216 -1 O ILE C 215 N ALA C 203 SHEET 1 AD3 3 LEU C 223 ARG C 224 0 SHEET 2 AD3 3 SER C 236 ASP C 243 -1 O THR C 242 N ARG C 224 SHEET 3 AD3 3 ALA C 231 VAL C 233 -1 N VAL C 233 O SER C 236 SHEET 1 AD4 4 LEU C 223 ARG C 224 0 SHEET 2 AD4 4 SER C 236 ASP C 243 -1 O THR C 242 N ARG C 224 SHEET 3 AD4 4 SER C 251 GLU C 258 -1 O PHE C 255 N THR C 239 SHEET 4 AD4 4 LYS C 261 GLU C 267 -1 O LYS C 264 N ARG C 256 SHEET 1 AD5 4 SER C 279 PRO C 282 0 SHEET 2 AD5 4 ILE C 287 VAL C 290 -1 O VAL C 290 N SER C 279 SHEET 3 AD5 4 PRO C 301 PHE C 305 -1 O PHE C 305 N ILE C 287 SHEET 4 AD5 4 TYR C 312 TYR C 316 -1 O GLY C 315 N TRP C 302 SHEET 1 AD6 4 PHE C 352 TYR C 356 0 SHEET 2 AD6 4 GLY C 359 ARG C 364 -1 O GLY C 359 N TYR C 356 SHEET 3 AD6 4 ASN C 372 ASP C 379 -1 O ILE C 377 N ILE C 362 SHEET 4 AD6 4 ILE C 392 TRP C 403 -1 O GLN C 395 N MET C 376 SHEET 1 AD7 4 GLN F 3 SER F 7 0 SHEET 2 AD7 4 LEU F 18 SER F 25 -1 O THR F 21 N SER F 7 SHEET 3 AD7 4 GLN F 77 LEU F 82 -1 O LEU F 82 N LEU F 18 SHEET 4 AD7 4 ALA F 67 ASP F 72 -1 N SER F 70 O SER F 79 SHEET 1 AD8 6 LEU F 11 VAL F 12 0 SHEET 2 AD8 6 THR F 107 VAL F 111 1 O THR F 110 N VAL F 12 SHEET 3 AD8 6 ALA F 88 GLY F 97 -1 N TYR F 90 O THR F 107 SHEET 4 AD8 6 LEU F 35 GLN F 39 -1 N LEU F 35 O VAL F 95 SHEET 5 AD8 6 GLU F 46 ILE F 51 -1 O GLU F 46 N ARG F 38 SHEET 6 AD8 6 TYR F 58 TYR F 59 -1 O TYR F 58 N TYR F 50 SHEET 1 AD9 4 LEU F 11 VAL F 12 0 SHEET 2 AD9 4 THR F 107 VAL F 111 1 O THR F 110 N VAL F 12 SHEET 3 AD9 4 ALA F 88 GLY F 97 -1 N TYR F 90 O THR F 107 SHEET 4 AD9 4 PHE F 100F TRP F 103 -1 O TYR F 100G N ASP F 96 SHEET 1 AE1 4 MET J 4 SER J 7 0 SHEET 2 AE1 4 VAL J 19 ALA J 25 -1 O THR J 22 N SER J 7 SHEET 3 AE1 4 ASP J 70 ILE J 75 -1 O PHE J 71 N CYS J 23 SHEET 4 AE1 4 PHE J 62 SER J 65 -1 N SER J 63 O THR J 74 SHEET 1 AE2 2 SER J 10 SER J 12 0 SHEET 2 AE2 2 LYS J 103 ASP J 105 1 O LYS J 103 N VAL J 11 SHEET 1 AE3 5 SER J 53 LEU J 54 0 SHEET 2 AE3 5 PRO J 44 TYR J 49 -1 N TYR J 49 O SER J 53 SHEET 3 AE3 5 LEU J 33 GLN J 38 -1 N TRP J 35 O LEU J 47 SHEET 4 AE3 5 THR J 85 GLN J 90 -1 O THR J 85 N GLN J 38 SHEET 5 AE3 5 THR J 97 PHE J 98 -1 O THR J 97 N GLN J 90 SHEET 1 AE4 4 GLY D 96 LYS D 102 0 SHEET 2 AE4 4 THR D 439 VAL D 449 -1 O SER D 445 N LEU D 100 SHEET 3 AE4 4 VAL D 419 GLY D 429 -1 N PRO D 420 O GLY D 448 SHEET 4 AE4 4 SER D 407 MET D 412 -1 N MET D 412 O VAL D 419 SHEET 1 AE5 4 PHE D 115 CYS D 124 0 SHEET 2 AE5 4 CYS D 129 LEU D 139 -1 O PHE D 132 N PHE D 121 SHEET 3 AE5 4 THR D 157 PRO D 162 -1 O MET D 159 N PHE D 133 SHEET 4 AE5 4 ARG D 172 ILE D 176 -1 O ARG D 172 N SER D 160 SHEET 1 AE6 4 SER D 179 HIS D 184 0 SHEET 2 AE6 4 TRP D 189 THR D 195 -1 O LEU D 190 N CYS D 183 SHEET 3 AE6 4 VAL D 202 TYR D 207 -1 O LYS D 206 N THR D 191 SHEET 4 AE6 4 ILE D 210 LYS D 216 -1 O ILE D 215 N ALA D 203 SHEET 1 AE7 3 LEU D 223 ARG D 224 0 SHEET 2 AE7 3 SER D 236 ASP D 243 -1 O THR D 242 N ARG D 224 SHEET 3 AE7 3 ALA D 231 VAL D 233 -1 N VAL D 233 O SER D 236 SHEET 1 AE8 4 LEU D 223 ARG D 224 0 SHEET 2 AE8 4 SER D 236 ASP D 243 -1 O THR D 242 N ARG D 224 SHEET 3 AE8 4 SER D 251 GLU D 258 -1 O PHE D 255 N THR D 239 SHEET 4 AE8 4 LYS D 261 GLU D 267 -1 O LYS D 264 N ARG D 256 SHEET 1 AE9 4 SER D 279 PRO D 282 0 SHEET 2 AE9 4 ILE D 287 VAL D 290 -1 O VAL D 290 N SER D 279 SHEET 3 AE9 4 PRO D 301 PHE D 305 -1 O PHE D 305 N ILE D 287 SHEET 4 AE9 4 TYR D 312 TYR D 316 -1 O GLY D 315 N TRP D 302 SHEET 1 AF1 4 PHE D 352 TYR D 356 0 SHEET 2 AF1 4 GLY D 359 ARG D 364 -1 O GLY D 359 N TYR D 356 SHEET 3 AF1 4 ASN D 372 ASP D 379 -1 O ILE D 377 N ILE D 362 SHEET 4 AF1 4 ILE D 392 TRP D 403 -1 O GLN D 395 N MET D 376 SHEET 1 AF2 4 GLN G 3 SER G 7 0 SHEET 2 AF2 4 LEU G 18 SER G 25 -1 O THR G 21 N SER G 7 SHEET 3 AF2 4 GLN G 77 LEU G 82 -1 O LEU G 82 N LEU G 18 SHEET 4 AF2 4 ALA G 67 ASP G 72 -1 N SER G 70 O SER G 79 SHEET 1 AF3 6 LEU G 11 VAL G 12 0 SHEET 2 AF3 6 THR G 107 VAL G 111 1 O THR G 110 N VAL G 12 SHEET 3 AF3 6 ALA G 88 GLY G 97 -1 N TYR G 90 O THR G 107 SHEET 4 AF3 6 LEU G 35 GLN G 39 -1 N LEU G 35 O VAL G 95 SHEET 5 AF3 6 GLU G 46 ILE G 51 -1 O GLU G 46 N ARG G 38 SHEET 6 AF3 6 TYR G 58 TYR G 59 -1 O TYR G 58 N TYR G 50 SHEET 1 AF4 4 LEU G 11 VAL G 12 0 SHEET 2 AF4 4 THR G 107 VAL G 111 1 O THR G 110 N VAL G 12 SHEET 3 AF4 4 ALA G 88 GLY G 97 -1 N TYR G 90 O THR G 107 SHEET 4 AF4 4 PHE G 100F TRP G 103 -1 O TYR G 100G N ASP G 96 SHEET 1 AF5 4 MET K 4 SER K 7 0 SHEET 2 AF5 4 VAL K 19 ALA K 25 -1 O THR K 22 N SER K 7 SHEET 3 AF5 4 ASP K 70 ILE K 75 -1 O PHE K 71 N CYS K 23 SHEET 4 AF5 4 PHE K 62 SER K 65 -1 N SER K 63 O THR K 74 SHEET 1 AF6 2 SER K 10 SER K 12 0 SHEET 2 AF6 2 LYS K 103 ASP K 105 1 O LYS K 103 N VAL K 11 SHEET 1 AF7 5 SER K 53 LEU K 54 0 SHEET 2 AF7 5 PRO K 44 TYR K 49 -1 N TYR K 49 O SER K 53 SHEET 3 AF7 5 LEU K 33 GLN K 38 -1 N TRP K 35 O LEU K 47 SHEET 4 AF7 5 THR K 85 GLN K 90 -1 O THR K 85 N GLN K 38 SHEET 5 AF7 5 THR K 97 PHE K 98 -1 O THR K 97 N GLN K 90 SSBOND 1 CYS A 92 CYS A 417 1555 1555 2.03 SSBOND 2 CYS A 124 CYS A 129 1555 1555 2.04 SSBOND 3 CYS A 183 CYS A 230 1555 1555 2.03 SSBOND 4 CYS A 232 CYS A 237 1555 1555 2.04 SSBOND 5 CYS A 278 CYS A 291 1555 1555 2.03 SSBOND 6 CYS A 280 CYS A 289 1555 1555 2.03 SSBOND 7 CYS A 318 CYS A 336 1555 1555 2.03 SSBOND 8 CYS A 421 CYS A 447 1555 1555 2.03 SSBOND 9 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 10 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 11 CYS B 92 CYS B 417 1555 1555 2.03 SSBOND 12 CYS B 124 CYS B 129 1555 1555 2.03 SSBOND 13 CYS B 183 CYS B 230 1555 1555 2.03 SSBOND 14 CYS B 232 CYS B 237 1555 1555 2.03 SSBOND 15 CYS B 278 CYS B 291 1555 1555 2.03 SSBOND 16 CYS B 280 CYS B 289 1555 1555 2.03 SSBOND 17 CYS B 318 CYS B 336 1555 1555 2.03 SSBOND 18 CYS B 421 CYS B 447 1555 1555 2.03 SSBOND 19 CYS E 22 CYS E 92 1555 1555 2.03 SSBOND 20 CYS I 23 CYS I 88 1555 1555 2.04 SSBOND 21 CYS C 92 CYS C 417 1555 1555 2.03 SSBOND 22 CYS C 124 CYS C 129 1555 1555 2.03 SSBOND 23 CYS C 183 CYS C 230 1555 1555 2.03 SSBOND 24 CYS C 232 CYS C 237 1555 1555 2.04 SSBOND 25 CYS C 278 CYS C 291 1555 1555 2.03 SSBOND 26 CYS C 280 CYS C 289 1555 1555 2.03 SSBOND 27 CYS C 318 CYS C 336 1555 1555 2.03 SSBOND 28 CYS C 421 CYS C 447 1555 1555 2.03 SSBOND 29 CYS F 22 CYS F 92 1555 1555 2.03 SSBOND 30 CYS J 23 CYS J 88 1555 1555 2.04 SSBOND 31 CYS D 92 CYS D 417 1555 1555 2.03 SSBOND 32 CYS D 124 CYS D 129 1555 1555 2.03 SSBOND 33 CYS D 183 CYS D 230 1555 1555 2.03 SSBOND 34 CYS D 232 CYS D 237 1555 1555 2.04 SSBOND 35 CYS D 278 CYS D 291 1555 1555 2.03 SSBOND 36 CYS D 280 CYS D 289 1555 1555 2.03 SSBOND 37 CYS D 318 CYS D 336 1555 1555 2.03 SSBOND 38 CYS D 421 CYS D 447 1555 1555 2.03 SSBOND 39 CYS G 22 CYS G 92 1555 1555 2.03 SSBOND 40 CYS K 23 CYS K 88 1555 1555 2.04 LINK ND2 ASN A 88 C1 NAG A 501 1555 1555 1.44 LINK ND2 ASN A 146 C1 NAG A 503 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A 502 1555 1555 1.44 LINK ND2 ASN B 88 C1 NAG B 501 1555 1555 1.44 LINK ND2 ASN B 146 C1 NAG B 503 1555 1555 1.44 LINK ND2 ASN B 234 C1 NAG B 502 1555 1555 1.44 LINK ND2 ASN C 88 C1 NAG C 501 1555 1555 1.44 LINK ND2 ASN C 146 C1 NAG C 503 1555 1555 1.44 LINK ND2 ASN C 234 C1 NAG C 502 1555 1555 1.44 LINK ND2 ASN D 88 C1 NAG D 501 1555 1555 1.44 LINK ND2 ASN D 146 C1 NAG D 503 1555 1555 1.44 LINK ND2 ASN D 234 C1 NAG D 502 1555 1555 1.44 LINK O ASP A 293 CA CA A 505 1555 1555 2.42 LINK O GLY A 297 CA CA A 505 1555 1555 2.36 LINK OD2 ASP A 324 CA CA A 505 1555 1555 2.34 LINK O GLY A 345 CA CA A 505 1555 1555 2.33 LINK O ASN A 347 CA CA A 505 1555 1555 2.37 LINK OD1 ASP A 379 CA CA A 506 1555 1555 2.37 LINK OD1 ASN A 381 CA CA A 506 1555 1555 2.46 LINK OD2 ASP A 387 CA CA A 506 1555 1555 3.04 LINK O ASN A 389 CA CA A 506 1555 1555 2.68 LINK O ASP B 293 CA CA B 504 1555 1555 2.42 LINK O GLY B 297 CA CA B 504 1555 1555 2.36 LINK OD2 ASP B 324 CA CA B 504 1555 1555 2.34 LINK O GLY B 345 CA CA B 504 1555 1555 2.33 LINK O ASN B 347 CA CA B 504 1555 1555 2.37 LINK OD1 ASP B 379 CA CA B 505 1555 1555 2.37 LINK OD1 ASN B 381 CA CA B 505 1555 1555 2.46 LINK OD2 ASP B 387 CA CA B 505 1555 1555 3.04 LINK O ASN B 389 CA CA B 505 1555 1555 2.68 LINK O ASP C 293 CA CA C 504 1555 1555 2.42 LINK O GLY C 297 CA CA C 504 1555 1555 2.36 LINK OD2 ASP C 324 CA CA C 504 1555 1555 2.34 LINK O GLY C 345 CA CA C 504 1555 1555 2.33 LINK O ASN C 347 CA CA C 504 1555 1555 2.37 LINK OD1 ASP C 379 CA CA C 505 1555 1555 2.37 LINK OD1 ASN C 381 CA CA C 505 1555 1555 2.46 LINK OD2 ASP C 387 CA CA C 505 1555 1555 3.04 LINK O ASN C 389 CA CA C 505 1555 1555 2.68 LINK O ASP D 293 CA CA D 504 1555 1555 2.42 LINK O GLY D 297 CA CA D 504 1555 1555 2.36 LINK OD2 ASP D 324 CA CA D 504 1555 1555 2.34 LINK O GLY D 345 CA CA D 504 1555 1555 2.33 LINK O ASN D 347 CA CA D 504 1555 1555 2.37 LINK OD1 ASP D 379 CA CA D 505 1555 1555 2.37 LINK OD1 ASN D 381 CA CA D 505 1555 1555 2.46 LINK OD2 ASP D 387 CA CA D 505 1555 1555 3.04 LINK O ASN D 389 CA CA D 505 1555 1555 2.68 CISPEP 1 SER L 7 PRO L 8 0 -4.31 CISPEP 2 SER I 7 PRO I 8 0 -4.31 CISPEP 3 SER J 7 PRO J 8 0 -4.31 CISPEP 4 SER K 7 PRO K 8 0 -4.31 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000