HEADER VIRAL PROTEIN/IMMUNE SYSTEM 02-AUG-24 9CYH TITLE CRYO-EM STRUCTURE OF DA03E17 FAB IN COMPLEX WITH INFLUENZA VIRUS TITLE 2 NEURAMINIDASE FROM B/COLORADO/06/2017 COMPND MOL_ID: 1; COMPND 2 MOLECULE: DA03E17 FAB HEAVY CHAIN; COMPND 3 CHAIN: H, E, F, G; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: DA03E17 FAB LIGHT CHAIN; COMPND 7 CHAIN: L, I, J, K; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: NEURAMINIDASE; COMPND 11 CHAIN: A, B, C, D; COMPND 12 EC: 3.2.1.18; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: INFLUENZA B VIRUS (B/COLORADO/06/2017); SOURCE 13 ORGANISM_TAXID: 1987257; SOURCE 14 GENE: NA; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS NEURAMINIDASE, HYDROLASE, ANTIBODY COMPLEX, VIRAL PROTEIN, VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.JO,A.B.WARD REVDAT 1 13-AUG-25 9CYH 0 JRNL AUTH G.JO,S.YAMAYOSHI,K.M.MA,O.SWANSON,J.L.TORRES,J.A.FERGUSON, JRNL AUTH 2 M.L.FERNANDEZ-QUINTERO,J.HUANG,J.COPPS,A.J.RODRIGUEZ, JRNL AUTH 3 J.M.STEICHEN,Y.KAWAOKA,J.HAN,A.B.WARD JRNL TITL STRUCTURAL BASIS OF BROAD PROTECTION AGAINST INFLUENZA VIRUS JRNL TITL 2 BY HUMAN ANTIBODIES TARGETING THE NEURAMINIDASE ACTIVE SITE JRNL TITL 3 VIA A RECURRING MOTIF IN CDR H3. JRNL REF NAT COMMUN V. 16 7067 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 40750588 JRNL DOI 10.1038/S41467-025-62174-2 REMARK 2 REMARK 2 RESOLUTION. 2.47 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, EPU, CRYOSPARC, PHENIX, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.470 REMARK 3 NUMBER OF PARTICLES : 420785 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9CYH COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-AUG-24. REMARK 100 THE DEPOSITION ID IS D_1000285696. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : DA03E17 FAB IN COMPLEX WITH REMARK 245 INFLUENZA VIRUS NEURAMINIDASE REMARK 245 FROM B/COLORADO/06/2017 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.40 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4506.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, A, E, I, B, F, J, C, G, REMARK 350 AND CHAINS: K, D, M, N, O, P, Q, R, S, T REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 MET A -15 REMARK 465 TYR A -14 REMARK 465 SER A -13 REMARK 465 MET A -12 REMARK 465 GLN A -11 REMARK 465 LEU A -10 REMARK 465 ALA A -9 REMARK 465 SER A -8 REMARK 465 CYS A -7 REMARK 465 VAL A -6 REMARK 465 THR A -5 REMARK 465 LEU A -4 REMARK 465 THR A -3 REMARK 465 LEU A -2 REMARK 465 VAL A -1 REMARK 465 LEU A 0 REMARK 465 LEU A 1 REMARK 465 VAL A 2 REMARK 465 ASN A 3 REMARK 465 SER A 4 REMARK 465 GLN A 5 REMARK 465 HIS A 6 REMARK 465 HIS A 7 REMARK 465 HIS A 8 REMARK 465 HIS A 9 REMARK 465 HIS A 10 REMARK 465 HIS A 11 REMARK 465 GLY A 12 REMARK 465 SER A 13 REMARK 465 ALA A 14 REMARK 465 TRP A 15 REMARK 465 SER A 16 REMARK 465 HIS A 17 REMARK 465 PRO A 18 REMARK 465 GLN A 19 REMARK 465 PHE A 20 REMARK 465 GLU A 21 REMARK 465 LYS A 22 REMARK 465 GLY A 23 REMARK 465 GLY A 24 REMARK 465 SER A 25 REMARK 465 SER A 26 REMARK 465 SER A 27 REMARK 465 ASP A 28 REMARK 465 TYR A 29 REMARK 465 SER A 30 REMARK 465 ASP A 31 REMARK 465 LEU A 32 REMARK 465 GLN A 33 REMARK 465 ARG A 34 REMARK 465 VAL A 35 REMARK 465 LYS A 36 REMARK 465 GLN A 37 REMARK 465 GLU A 38 REMARK 465 LEU A 39 REMARK 465 LEU A 40 REMARK 465 GLU A 41 REMARK 465 GLU A 42 REMARK 465 VAL A 43 REMARK 465 LYS A 44 REMARK 465 LYS A 45 REMARK 465 GLU A 46 REMARK 465 LEU A 47 REMARK 465 GLN A 48 REMARK 465 LYS A 49 REMARK 465 VAL A 50 REMARK 465 LYS A 51 REMARK 465 GLU A 52 REMARK 465 GLU A 53 REMARK 465 ILE A 54 REMARK 465 ILE A 55 REMARK 465 GLU A 56 REMARK 465 ALA A 57 REMARK 465 PHE A 58 REMARK 465 VAL A 59 REMARK 465 GLN A 60 REMARK 465 GLU A 61 REMARK 465 LEU A 62 REMARK 465 ARG A 63 REMARK 465 LYS A 64 REMARK 465 ARG A 65 REMARK 465 GLY A 66 REMARK 465 SER A 67 REMARK 465 LEU A 68 REMARK 465 VAL A 69 REMARK 465 PRO A 70 REMARK 465 ARG A 71 REMARK 465 GLY A 72 REMARK 465 SER A 73 REMARK 465 GLY A 74 REMARK 465 GLY A 75 REMARK 465 PRO A 76 REMARK 465 ALA E 114 REMARK 465 SER E 115 REMARK 465 THR E 116 REMARK 465 LYS E 117 REMARK 465 GLY E 118 REMARK 465 PRO E 119 REMARK 465 SER E 120 REMARK 465 VAL E 121 REMARK 465 PHE E 122 REMARK 465 PRO E 123 REMARK 465 LEU E 124 REMARK 465 ALA E 125 REMARK 465 PRO E 126 REMARK 465 SER E 127 REMARK 465 SER E 128 REMARK 465 LYS E 129 REMARK 465 SER E 130 REMARK 465 THR E 131 REMARK 465 SER E 132 REMARK 465 GLY E 133 REMARK 465 GLY E 134 REMARK 465 THR E 135 REMARK 465 ALA E 136 REMARK 465 ALA E 137 REMARK 465 LEU E 138 REMARK 465 GLY E 139 REMARK 465 CYS E 140 REMARK 465 LEU E 141 REMARK 465 VAL E 142 REMARK 465 LYS E 143 REMARK 465 ASP E 144 REMARK 465 TYR E 145 REMARK 465 PHE E 146 REMARK 465 PRO E 147 REMARK 465 GLU E 148 REMARK 465 PRO E 149 REMARK 465 VAL E 150 REMARK 465 THR E 151 REMARK 465 VAL E 152 REMARK 465 SER E 153 REMARK 465 TRP E 154 REMARK 465 ASN E 155 REMARK 465 SER E 156 REMARK 465 GLY E 157 REMARK 465 ALA E 158 REMARK 465 LEU E 159 REMARK 465 THR E 160 REMARK 465 SER E 161 REMARK 465 GLY E 162 REMARK 465 VAL E 163 REMARK 465 HIS E 164 REMARK 465 THR E 165 REMARK 465 PHE E 166 REMARK 465 PRO E 167 REMARK 465 ALA E 168 REMARK 465 VAL E 169 REMARK 465 LEU E 170 REMARK 465 GLN E 171 REMARK 465 SER E 172 REMARK 465 SER E 173 REMARK 465 GLY E 174 REMARK 465 LEU E 175 REMARK 465 TYR E 176 REMARK 465 SER E 177 REMARK 465 LEU E 178 REMARK 465 SER E 179 REMARK 465 SER E 180 REMARK 465 VAL E 181 REMARK 465 VAL E 182 REMARK 465 THR E 183 REMARK 465 VAL E 184 REMARK 465 PRO E 185 REMARK 465 SER E 186 REMARK 465 SER E 187 REMARK 465 SER E 188 REMARK 465 LEU E 189 REMARK 465 GLY E 190 REMARK 465 THR E 191 REMARK 465 GLN E 192 REMARK 465 THR E 193 REMARK 465 TYR E 194 REMARK 465 ILE E 195 REMARK 465 CYS E 196 REMARK 465 ASN E 197 REMARK 465 VAL E 198 REMARK 465 ASN E 199 REMARK 465 HIS E 200 REMARK 465 LYS E 201 REMARK 465 PRO E 202 REMARK 465 SER E 203 REMARK 465 ASN E 204 REMARK 465 THR E 205 REMARK 465 LYS E 206 REMARK 465 VAL E 207 REMARK 465 ASP E 208 REMARK 465 LYS E 209 REMARK 465 ARG E 210 REMARK 465 VAL E 211 REMARK 465 GLU E 212 REMARK 465 PRO E 213 REMARK 465 LYS E 214 REMARK 465 SER E 215 REMARK 465 CYS E 216 REMARK 465 ASP E 217 REMARK 465 ARG I 108 REMARK 465 THR I 109 REMARK 465 VAL I 110 REMARK 465 ALA I 111 REMARK 465 ALA I 112 REMARK 465 PRO I 113 REMARK 465 SER I 114 REMARK 465 VAL I 115 REMARK 465 PHE I 116 REMARK 465 ILE I 117 REMARK 465 PHE I 118 REMARK 465 PRO I 119 REMARK 465 PRO I 120 REMARK 465 SER I 121 REMARK 465 ASP I 122 REMARK 465 GLU I 123 REMARK 465 GLN I 124 REMARK 465 LEU I 125 REMARK 465 LYS I 126 REMARK 465 SER I 127 REMARK 465 GLY I 128 REMARK 465 THR I 129 REMARK 465 ALA I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 VAL I 133 REMARK 465 CYS I 134 REMARK 465 LEU I 135 REMARK 465 LEU I 136 REMARK 465 ASN I 137 REMARK 465 ASN I 138 REMARK 465 PHE I 139 REMARK 465 TYR I 140 REMARK 465 PRO I 141 REMARK 465 ARG I 142 REMARK 465 GLU I 143 REMARK 465 ALA I 144 REMARK 465 LYS I 145 REMARK 465 VAL I 146 REMARK 465 GLN I 147 REMARK 465 TRP I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 ASP I 151 REMARK 465 ASN I 152 REMARK 465 ALA I 153 REMARK 465 LEU I 154 REMARK 465 GLN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLN I 160 REMARK 465 GLU I 161 REMARK 465 SER I 162 REMARK 465 VAL I 163 REMARK 465 THR I 164 REMARK 465 GLU I 165 REMARK 465 GLN I 166 REMARK 465 ASP I 167 REMARK 465 SER I 168 REMARK 465 LYS I 169 REMARK 465 ASP I 170 REMARK 465 SER I 171 REMARK 465 THR I 172 REMARK 465 TYR I 173 REMARK 465 SER I 174 REMARK 465 LEU I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 THR I 178 REMARK 465 LEU I 179 REMARK 465 THR I 180 REMARK 465 LEU I 181 REMARK 465 SER I 182 REMARK 465 LYS I 183 REMARK 465 ALA I 184 REMARK 465 ASP I 185 REMARK 465 TYR I 186 REMARK 465 GLU I 187 REMARK 465 LYS I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 VAL I 191 REMARK 465 TYR I 192 REMARK 465 ALA I 193 REMARK 465 CYS I 194 REMARK 465 GLU I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLN I 199 REMARK 465 GLY I 200 REMARK 465 LEU I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 PRO I 204 REMARK 465 VAL I 205 REMARK 465 THR I 206 REMARK 465 LYS I 207 REMARK 465 SER I 208 REMARK 465 PHE I 209 REMARK 465 ASN I 210 REMARK 465 ARG I 211 REMARK 465 GLY I 212 REMARK 465 GLU I 213 REMARK 465 CYS I 214 REMARK 465 MET B -15 REMARK 465 TYR B -14 REMARK 465 SER B -13 REMARK 465 MET B -12 REMARK 465 GLN B -11 REMARK 465 LEU B -10 REMARK 465 ALA B -9 REMARK 465 SER B -8 REMARK 465 CYS B -7 REMARK 465 VAL B -6 REMARK 465 THR B -5 REMARK 465 LEU B -4 REMARK 465 THR B -3 REMARK 465 LEU B -2 REMARK 465 VAL B -1 REMARK 465 LEU B 0 REMARK 465 LEU B 1 REMARK 465 VAL B 2 REMARK 465 ASN B 3 REMARK 465 SER B 4 REMARK 465 GLN B 5 REMARK 465 HIS B 6 REMARK 465 HIS B 7 REMARK 465 HIS B 8 REMARK 465 HIS B 9 REMARK 465 HIS B 10 REMARK 465 HIS B 11 REMARK 465 GLY B 12 REMARK 465 SER B 13 REMARK 465 ALA B 14 REMARK 465 TRP B 15 REMARK 465 SER B 16 REMARK 465 HIS B 17 REMARK 465 PRO B 18 REMARK 465 GLN B 19 REMARK 465 PHE B 20 REMARK 465 GLU B 21 REMARK 465 LYS B 22 REMARK 465 GLY B 23 REMARK 465 GLY B 24 REMARK 465 SER B 25 REMARK 465 SER B 26 REMARK 465 SER B 27 REMARK 465 ASP B 28 REMARK 465 TYR B 29 REMARK 465 SER B 30 REMARK 465 ASP B 31 REMARK 465 LEU B 32 REMARK 465 GLN B 33 REMARK 465 ARG B 34 REMARK 465 VAL B 35 REMARK 465 LYS B 36 REMARK 465 GLN B 37 REMARK 465 GLU B 38 REMARK 465 LEU B 39 REMARK 465 LEU B 40 REMARK 465 GLU B 41 REMARK 465 GLU B 42 REMARK 465 VAL B 43 REMARK 465 LYS B 44 REMARK 465 LYS B 45 REMARK 465 GLU B 46 REMARK 465 LEU B 47 REMARK 465 GLN B 48 REMARK 465 LYS B 49 REMARK 465 VAL B 50 REMARK 465 LYS B 51 REMARK 465 GLU B 52 REMARK 465 GLU B 53 REMARK 465 ILE B 54 REMARK 465 ILE B 55 REMARK 465 GLU B 56 REMARK 465 ALA B 57 REMARK 465 PHE B 58 REMARK 465 VAL B 59 REMARK 465 GLN B 60 REMARK 465 GLU B 61 REMARK 465 LEU B 62 REMARK 465 ARG B 63 REMARK 465 LYS B 64 REMARK 465 ARG B 65 REMARK 465 GLY B 66 REMARK 465 SER B 67 REMARK 465 LEU B 68 REMARK 465 VAL B 69 REMARK 465 PRO B 70 REMARK 465 ARG B 71 REMARK 465 GLY B 72 REMARK 465 SER B 73 REMARK 465 GLY B 74 REMARK 465 GLY B 75 REMARK 465 PRO B 76 REMARK 465 ALA F 114 REMARK 465 SER F 115 REMARK 465 THR F 116 REMARK 465 LYS F 117 REMARK 465 GLY F 118 REMARK 465 PRO F 119 REMARK 465 SER F 120 REMARK 465 VAL F 121 REMARK 465 PHE F 122 REMARK 465 PRO F 123 REMARK 465 LEU F 124 REMARK 465 ALA F 125 REMARK 465 PRO F 126 REMARK 465 SER F 127 REMARK 465 SER F 128 REMARK 465 LYS F 129 REMARK 465 SER F 130 REMARK 465 THR F 131 REMARK 465 SER F 132 REMARK 465 GLY F 133 REMARK 465 GLY F 134 REMARK 465 THR F 135 REMARK 465 ALA F 136 REMARK 465 ALA F 137 REMARK 465 LEU F 138 REMARK 465 GLY F 139 REMARK 465 CYS F 140 REMARK 465 LEU F 141 REMARK 465 VAL F 142 REMARK 465 LYS F 143 REMARK 465 ASP F 144 REMARK 465 TYR F 145 REMARK 465 PHE F 146 REMARK 465 PRO F 147 REMARK 465 GLU F 148 REMARK 465 PRO F 149 REMARK 465 VAL F 150 REMARK 465 THR F 151 REMARK 465 VAL F 152 REMARK 465 SER F 153 REMARK 465 TRP F 154 REMARK 465 ASN F 155 REMARK 465 SER F 156 REMARK 465 GLY F 157 REMARK 465 ALA F 158 REMARK 465 LEU F 159 REMARK 465 THR F 160 REMARK 465 SER F 161 REMARK 465 GLY F 162 REMARK 465 VAL F 163 REMARK 465 HIS F 164 REMARK 465 THR F 165 REMARK 465 PHE F 166 REMARK 465 PRO F 167 REMARK 465 ALA F 168 REMARK 465 VAL F 169 REMARK 465 LEU F 170 REMARK 465 GLN F 171 REMARK 465 SER F 172 REMARK 465 SER F 173 REMARK 465 GLY F 174 REMARK 465 LEU F 175 REMARK 465 TYR F 176 REMARK 465 SER F 177 REMARK 465 LEU F 178 REMARK 465 SER F 179 REMARK 465 SER F 180 REMARK 465 VAL F 181 REMARK 465 VAL F 182 REMARK 465 THR F 183 REMARK 465 VAL F 184 REMARK 465 PRO F 185 REMARK 465 SER F 186 REMARK 465 SER F 187 REMARK 465 SER F 188 REMARK 465 LEU F 189 REMARK 465 GLY F 190 REMARK 465 THR F 191 REMARK 465 GLN F 192 REMARK 465 THR F 193 REMARK 465 TYR F 194 REMARK 465 ILE F 195 REMARK 465 CYS F 196 REMARK 465 ASN F 197 REMARK 465 VAL F 198 REMARK 465 ASN F 199 REMARK 465 HIS F 200 REMARK 465 LYS F 201 REMARK 465 PRO F 202 REMARK 465 SER F 203 REMARK 465 ASN F 204 REMARK 465 THR F 205 REMARK 465 LYS F 206 REMARK 465 VAL F 207 REMARK 465 ASP F 208 REMARK 465 LYS F 209 REMARK 465 ARG F 210 REMARK 465 VAL F 211 REMARK 465 GLU F 212 REMARK 465 PRO F 213 REMARK 465 LYS F 214 REMARK 465 SER F 215 REMARK 465 CYS F 216 REMARK 465 ASP F 217 REMARK 465 ARG J 108 REMARK 465 THR J 109 REMARK 465 VAL J 110 REMARK 465 ALA J 111 REMARK 465 ALA J 112 REMARK 465 PRO J 113 REMARK 465 SER J 114 REMARK 465 VAL J 115 REMARK 465 PHE J 116 REMARK 465 ILE J 117 REMARK 465 PHE J 118 REMARK 465 PRO J 119 REMARK 465 PRO J 120 REMARK 465 SER J 121 REMARK 465 ASP J 122 REMARK 465 GLU J 123 REMARK 465 GLN J 124 REMARK 465 LEU J 125 REMARK 465 LYS J 126 REMARK 465 SER J 127 REMARK 465 GLY J 128 REMARK 465 THR J 129 REMARK 465 ALA J 130 REMARK 465 SER J 131 REMARK 465 VAL J 132 REMARK 465 VAL J 133 REMARK 465 CYS J 134 REMARK 465 LEU J 135 REMARK 465 LEU J 136 REMARK 465 ASN J 137 REMARK 465 ASN J 138 REMARK 465 PHE J 139 REMARK 465 TYR J 140 REMARK 465 PRO J 141 REMARK 465 ARG J 142 REMARK 465 GLU J 143 REMARK 465 ALA J 144 REMARK 465 LYS J 145 REMARK 465 VAL J 146 REMARK 465 GLN J 147 REMARK 465 TRP J 148 REMARK 465 LYS J 149 REMARK 465 VAL J 150 REMARK 465 ASP J 151 REMARK 465 ASN J 152 REMARK 465 ALA J 153 REMARK 465 LEU J 154 REMARK 465 GLN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ASN J 158 REMARK 465 SER J 159 REMARK 465 GLN J 160 REMARK 465 GLU J 161 REMARK 465 SER J 162 REMARK 465 VAL J 163 REMARK 465 THR J 164 REMARK 465 GLU J 165 REMARK 465 GLN J 166 REMARK 465 ASP J 167 REMARK 465 SER J 168 REMARK 465 LYS J 169 REMARK 465 ASP J 170 REMARK 465 SER J 171 REMARK 465 THR J 172 REMARK 465 TYR J 173 REMARK 465 SER J 174 REMARK 465 LEU J 175 REMARK 465 SER J 176 REMARK 465 SER J 177 REMARK 465 THR J 178 REMARK 465 LEU J 179 REMARK 465 THR J 180 REMARK 465 LEU J 181 REMARK 465 SER J 182 REMARK 465 LYS J 183 REMARK 465 ALA J 184 REMARK 465 ASP J 185 REMARK 465 TYR J 186 REMARK 465 GLU J 187 REMARK 465 LYS J 188 REMARK 465 HIS J 189 REMARK 465 LYS J 190 REMARK 465 VAL J 191 REMARK 465 TYR J 192 REMARK 465 ALA J 193 REMARK 465 CYS J 194 REMARK 465 GLU J 195 REMARK 465 VAL J 196 REMARK 465 THR J 197 REMARK 465 HIS J 198 REMARK 465 GLN J 199 REMARK 465 GLY J 200 REMARK 465 LEU J 201 REMARK 465 SER J 202 REMARK 465 SER J 203 REMARK 465 PRO J 204 REMARK 465 VAL J 205 REMARK 465 THR J 206 REMARK 465 LYS J 207 REMARK 465 SER J 208 REMARK 465 PHE J 209 REMARK 465 ASN J 210 REMARK 465 ARG J 211 REMARK 465 GLY J 212 REMARK 465 GLU J 213 REMARK 465 CYS J 214 REMARK 465 MET C -15 REMARK 465 TYR C -14 REMARK 465 SER C -13 REMARK 465 MET C -12 REMARK 465 GLN C -11 REMARK 465 LEU C -10 REMARK 465 ALA C -9 REMARK 465 SER C -8 REMARK 465 CYS C -7 REMARK 465 VAL C -6 REMARK 465 THR C -5 REMARK 465 LEU C -4 REMARK 465 THR C -3 REMARK 465 LEU C -2 REMARK 465 VAL C -1 REMARK 465 LEU C 0 REMARK 465 LEU C 1 REMARK 465 VAL C 2 REMARK 465 ASN C 3 REMARK 465 SER C 4 REMARK 465 GLN C 5 REMARK 465 HIS C 6 REMARK 465 HIS C 7 REMARK 465 HIS C 8 REMARK 465 HIS C 9 REMARK 465 HIS C 10 REMARK 465 HIS C 11 REMARK 465 GLY C 12 REMARK 465 SER C 13 REMARK 465 ALA C 14 REMARK 465 TRP C 15 REMARK 465 SER C 16 REMARK 465 HIS C 17 REMARK 465 PRO C 18 REMARK 465 GLN C 19 REMARK 465 PHE C 20 REMARK 465 GLU C 21 REMARK 465 LYS C 22 REMARK 465 GLY C 23 REMARK 465 GLY C 24 REMARK 465 SER C 25 REMARK 465 SER C 26 REMARK 465 SER C 27 REMARK 465 ASP C 28 REMARK 465 TYR C 29 REMARK 465 SER C 30 REMARK 465 ASP C 31 REMARK 465 LEU C 32 REMARK 465 GLN C 33 REMARK 465 ARG C 34 REMARK 465 VAL C 35 REMARK 465 LYS C 36 REMARK 465 GLN C 37 REMARK 465 GLU C 38 REMARK 465 LEU C 39 REMARK 465 LEU C 40 REMARK 465 GLU C 41 REMARK 465 GLU C 42 REMARK 465 VAL C 43 REMARK 465 LYS C 44 REMARK 465 LYS C 45 REMARK 465 GLU C 46 REMARK 465 LEU C 47 REMARK 465 GLN C 48 REMARK 465 LYS C 49 REMARK 465 VAL C 50 REMARK 465 LYS C 51 REMARK 465 GLU C 52 REMARK 465 GLU C 53 REMARK 465 ILE C 54 REMARK 465 ILE C 55 REMARK 465 GLU C 56 REMARK 465 ALA C 57 REMARK 465 PHE C 58 REMARK 465 VAL C 59 REMARK 465 GLN C 60 REMARK 465 GLU C 61 REMARK 465 LEU C 62 REMARK 465 ARG C 63 REMARK 465 LYS C 64 REMARK 465 ARG C 65 REMARK 465 GLY C 66 REMARK 465 SER C 67 REMARK 465 LEU C 68 REMARK 465 VAL C 69 REMARK 465 PRO C 70 REMARK 465 ARG C 71 REMARK 465 GLY C 72 REMARK 465 SER C 73 REMARK 465 GLY C 74 REMARK 465 GLY C 75 REMARK 465 PRO C 76 REMARK 465 ALA G 114 REMARK 465 SER G 115 REMARK 465 THR G 116 REMARK 465 LYS G 117 REMARK 465 GLY G 118 REMARK 465 PRO G 119 REMARK 465 SER G 120 REMARK 465 VAL G 121 REMARK 465 PHE G 122 REMARK 465 PRO G 123 REMARK 465 LEU G 124 REMARK 465 ALA G 125 REMARK 465 PRO G 126 REMARK 465 SER G 127 REMARK 465 SER G 128 REMARK 465 LYS G 129 REMARK 465 SER G 130 REMARK 465 THR G 131 REMARK 465 SER G 132 REMARK 465 GLY G 133 REMARK 465 GLY G 134 REMARK 465 THR G 135 REMARK 465 ALA G 136 REMARK 465 ALA G 137 REMARK 465 LEU G 138 REMARK 465 GLY G 139 REMARK 465 CYS G 140 REMARK 465 LEU G 141 REMARK 465 VAL G 142 REMARK 465 LYS G 143 REMARK 465 ASP G 144 REMARK 465 TYR G 145 REMARK 465 PHE G 146 REMARK 465 PRO G 147 REMARK 465 GLU G 148 REMARK 465 PRO G 149 REMARK 465 VAL G 150 REMARK 465 THR G 151 REMARK 465 VAL G 152 REMARK 465 SER G 153 REMARK 465 TRP G 154 REMARK 465 ASN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ALA G 158 REMARK 465 LEU G 159 REMARK 465 THR G 160 REMARK 465 SER G 161 REMARK 465 GLY G 162 REMARK 465 VAL G 163 REMARK 465 HIS G 164 REMARK 465 THR G 165 REMARK 465 PHE G 166 REMARK 465 PRO G 167 REMARK 465 ALA G 168 REMARK 465 VAL G 169 REMARK 465 LEU G 170 REMARK 465 GLN G 171 REMARK 465 SER G 172 REMARK 465 SER G 173 REMARK 465 GLY G 174 REMARK 465 LEU G 175 REMARK 465 TYR G 176 REMARK 465 SER G 177 REMARK 465 LEU G 178 REMARK 465 SER G 179 REMARK 465 SER G 180 REMARK 465 VAL G 181 REMARK 465 VAL G 182 REMARK 465 THR G 183 REMARK 465 VAL G 184 REMARK 465 PRO G 185 REMARK 465 SER G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 LEU G 189 REMARK 465 GLY G 190 REMARK 465 THR G 191 REMARK 465 GLN G 192 REMARK 465 THR G 193 REMARK 465 TYR G 194 REMARK 465 ILE G 195 REMARK 465 CYS G 196 REMARK 465 ASN G 197 REMARK 465 VAL G 198 REMARK 465 ASN G 199 REMARK 465 HIS G 200 REMARK 465 LYS G 201 REMARK 465 PRO G 202 REMARK 465 SER G 203 REMARK 465 ASN G 204 REMARK 465 THR G 205 REMARK 465 LYS G 206 REMARK 465 VAL G 207 REMARK 465 ASP G 208 REMARK 465 LYS G 209 REMARK 465 ARG G 210 REMARK 465 VAL G 211 REMARK 465 GLU G 212 REMARK 465 PRO G 213 REMARK 465 LYS G 214 REMARK 465 SER G 215 REMARK 465 CYS G 216 REMARK 465 ASP G 217 REMARK 465 ARG K 108 REMARK 465 THR K 109 REMARK 465 VAL K 110 REMARK 465 ALA K 111 REMARK 465 ALA K 112 REMARK 465 PRO K 113 REMARK 465 SER K 114 REMARK 465 VAL K 115 REMARK 465 PHE K 116 REMARK 465 ILE K 117 REMARK 465 PHE K 118 REMARK 465 PRO K 119 REMARK 465 PRO K 120 REMARK 465 SER K 121 REMARK 465 ASP K 122 REMARK 465 GLU K 123 REMARK 465 GLN K 124 REMARK 465 LEU K 125 REMARK 465 LYS K 126 REMARK 465 SER K 127 REMARK 465 GLY K 128 REMARK 465 THR K 129 REMARK 465 ALA K 130 REMARK 465 SER K 131 REMARK 465 VAL K 132 REMARK 465 VAL K 133 REMARK 465 CYS K 134 REMARK 465 LEU K 135 REMARK 465 LEU K 136 REMARK 465 ASN K 137 REMARK 465 ASN K 138 REMARK 465 PHE K 139 REMARK 465 TYR K 140 REMARK 465 PRO K 141 REMARK 465 ARG K 142 REMARK 465 GLU K 143 REMARK 465 ALA K 144 REMARK 465 LYS K 145 REMARK 465 VAL K 146 REMARK 465 GLN K 147 REMARK 465 TRP K 148 REMARK 465 LYS K 149 REMARK 465 VAL K 150 REMARK 465 ASP K 151 REMARK 465 ASN K 152 REMARK 465 ALA K 153 REMARK 465 LEU K 154 REMARK 465 GLN K 155 REMARK 465 SER K 156 REMARK 465 GLY K 157 REMARK 465 ASN K 158 REMARK 465 SER K 159 REMARK 465 GLN K 160 REMARK 465 GLU K 161 REMARK 465 SER K 162 REMARK 465 VAL K 163 REMARK 465 THR K 164 REMARK 465 GLU K 165 REMARK 465 GLN K 166 REMARK 465 ASP K 167 REMARK 465 SER K 168 REMARK 465 LYS K 169 REMARK 465 ASP K 170 REMARK 465 SER K 171 REMARK 465 THR K 172 REMARK 465 TYR K 173 REMARK 465 SER K 174 REMARK 465 LEU K 175 REMARK 465 SER K 176 REMARK 465 SER K 177 REMARK 465 THR K 178 REMARK 465 LEU K 179 REMARK 465 THR K 180 REMARK 465 LEU K 181 REMARK 465 SER K 182 REMARK 465 LYS K 183 REMARK 465 ALA K 184 REMARK 465 ASP K 185 REMARK 465 TYR K 186 REMARK 465 GLU K 187 REMARK 465 LYS K 188 REMARK 465 HIS K 189 REMARK 465 LYS K 190 REMARK 465 VAL K 191 REMARK 465 TYR K 192 REMARK 465 ALA K 193 REMARK 465 CYS K 194 REMARK 465 GLU K 195 REMARK 465 VAL K 196 REMARK 465 THR K 197 REMARK 465 HIS K 198 REMARK 465 GLN K 199 REMARK 465 GLY K 200 REMARK 465 LEU K 201 REMARK 465 SER K 202 REMARK 465 SER K 203 REMARK 465 PRO K 204 REMARK 465 VAL K 205 REMARK 465 THR K 206 REMARK 465 LYS K 207 REMARK 465 SER K 208 REMARK 465 PHE K 209 REMARK 465 ASN K 210 REMARK 465 ARG K 211 REMARK 465 GLY K 212 REMARK 465 GLU K 213 REMARK 465 CYS K 214 REMARK 465 MET D -15 REMARK 465 TYR D -14 REMARK 465 SER D -13 REMARK 465 MET D -12 REMARK 465 GLN D -11 REMARK 465 LEU D -10 REMARK 465 ALA D -9 REMARK 465 SER D -8 REMARK 465 CYS D -7 REMARK 465 VAL D -6 REMARK 465 THR D -5 REMARK 465 LEU D -4 REMARK 465 THR D -3 REMARK 465 LEU D -2 REMARK 465 VAL D -1 REMARK 465 LEU D 0 REMARK 465 LEU D 1 REMARK 465 VAL D 2 REMARK 465 ASN D 3 REMARK 465 SER D 4 REMARK 465 GLN D 5 REMARK 465 HIS D 6 REMARK 465 HIS D 7 REMARK 465 HIS D 8 REMARK 465 HIS D 9 REMARK 465 HIS D 10 REMARK 465 HIS D 11 REMARK 465 GLY D 12 REMARK 465 SER D 13 REMARK 465 ALA D 14 REMARK 465 TRP D 15 REMARK 465 SER D 16 REMARK 465 HIS D 17 REMARK 465 PRO D 18 REMARK 465 GLN D 19 REMARK 465 PHE D 20 REMARK 465 GLU D 21 REMARK 465 LYS D 22 REMARK 465 GLY D 23 REMARK 465 GLY D 24 REMARK 465 SER D 25 REMARK 465 SER D 26 REMARK 465 SER D 27 REMARK 465 ASP D 28 REMARK 465 TYR D 29 REMARK 465 SER D 30 REMARK 465 ASP D 31 REMARK 465 LEU D 32 REMARK 465 GLN D 33 REMARK 465 ARG D 34 REMARK 465 VAL D 35 REMARK 465 LYS D 36 REMARK 465 GLN D 37 REMARK 465 GLU D 38 REMARK 465 LEU D 39 REMARK 465 LEU D 40 REMARK 465 GLU D 41 REMARK 465 GLU D 42 REMARK 465 VAL D 43 REMARK 465 LYS D 44 REMARK 465 LYS D 45 REMARK 465 GLU D 46 REMARK 465 LEU D 47 REMARK 465 GLN D 48 REMARK 465 LYS D 49 REMARK 465 VAL D 50 REMARK 465 LYS D 51 REMARK 465 GLU D 52 REMARK 465 GLU D 53 REMARK 465 ILE D 54 REMARK 465 ILE D 55 REMARK 465 GLU D 56 REMARK 465 ALA D 57 REMARK 465 PHE D 58 REMARK 465 VAL D 59 REMARK 465 GLN D 60 REMARK 465 GLU D 61 REMARK 465 LEU D 62 REMARK 465 ARG D 63 REMARK 465 LYS D 64 REMARK 465 ARG D 65 REMARK 465 GLY D 66 REMARK 465 SER D 67 REMARK 465 LEU D 68 REMARK 465 VAL D 69 REMARK 465 PRO D 70 REMARK 465 ARG D 71 REMARK 465 GLY D 72 REMARK 465 SER D 73 REMARK 465 GLY D 74 REMARK 465 GLY D 75 REMARK 465 PRO D 76 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER L 9 -32.37 72.31 REMARK 500 ALA L 51 -10.86 72.90 REMARK 500 SER L 65 147.18 -175.69 REMARK 500 SER A 90 -31.94 -136.43 REMARK 500 SER A 283 -166.86 -168.64 REMARK 500 TRP A 408 -161.05 -100.87 REMARK 500 TYR A 409 124.57 -39.11 REMARK 500 SER I 9 -32.41 72.34 REMARK 500 ALA I 51 -10.87 72.96 REMARK 500 SER I 65 147.21 -175.64 REMARK 500 SER B 90 -31.92 -136.48 REMARK 500 SER B 283 -166.84 -168.61 REMARK 500 TRP B 408 -160.99 -100.89 REMARK 500 TYR B 409 124.63 -39.12 REMARK 500 SER J 9 -32.38 72.27 REMARK 500 ALA J 51 -10.88 72.90 REMARK 500 SER J 65 147.18 -175.71 REMARK 500 SER C 90 -31.87 -136.48 REMARK 500 SER C 283 -166.87 -168.64 REMARK 500 TRP C 408 -161.06 -100.93 REMARK 500 TYR C 409 124.53 -39.05 REMARK 500 SER K 9 -32.41 72.38 REMARK 500 ALA K 51 -10.88 72.90 REMARK 500 SER K 65 147.21 -175.64 REMARK 500 SER D 90 -31.81 -136.46 REMARK 500 SER D 283 -166.87 -168.63 REMARK 500 TRP D 408 -161.02 -100.91 REMARK 500 TYR D 409 124.56 -39.16 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG H 38 0.21 SIDE CHAIN REMARK 500 ARG L 24 0.22 SIDE CHAIN REMARK 500 ARG L 27 0.08 SIDE CHAIN REMARK 500 ARG A 150 0.23 SIDE CHAIN REMARK 500 ARG A 270 0.07 SIDE CHAIN REMARK 500 ARG E 38 0.21 SIDE CHAIN REMARK 500 ARG I 24 0.22 SIDE CHAIN REMARK 500 ARG I 27 0.08 SIDE CHAIN REMARK 500 ARG B 150 0.23 SIDE CHAIN REMARK 500 ARG B 270 0.07 SIDE CHAIN REMARK 500 ARG F 38 0.21 SIDE CHAIN REMARK 500 ARG J 24 0.22 SIDE CHAIN REMARK 500 ARG J 27 0.08 SIDE CHAIN REMARK 500 ARG C 150 0.23 SIDE CHAIN REMARK 500 ARG C 270 0.07 SIDE CHAIN REMARK 500 ARG G 38 0.21 SIDE CHAIN REMARK 500 ARG K 24 0.22 SIDE CHAIN REMARK 500 ARG K 27 0.08 SIDE CHAIN REMARK 500 ARG D 150 0.23 SIDE CHAIN REMARK 500 ARG D 270 0.07 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA A 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP A 293 O REMARK 620 2 THR A 297 O 85.4 REMARK 620 3 ASP A 324 OD2 86.6 104.9 REMARK 620 4 GLY A 344 O 110.2 86.1 160.9 REMARK 620 5 GLY A 346 O 94.1 164.0 91.0 79.1 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA B 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP B 293 O REMARK 620 2 THR B 297 O 85.5 REMARK 620 3 ASP B 324 OD2 86.6 104.9 REMARK 620 4 GLY B 344 O 110.3 86.1 160.9 REMARK 620 5 GLY B 346 O 94.2 164.1 91.0 79.1 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA C 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP C 293 O REMARK 620 2 THR C 297 O 85.5 REMARK 620 3 ASP C 324 OD2 86.6 104.9 REMARK 620 4 GLY C 344 O 110.2 86.0 160.9 REMARK 620 5 GLY C 346 O 94.2 164.0 91.0 79.1 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA D 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP D 293 O REMARK 620 2 THR D 297 O 85.5 REMARK 620 3 ASP D 324 OD2 86.6 104.9 REMARK 620 4 GLY D 344 O 110.2 86.0 160.9 REMARK 620 5 GLY D 346 O 94.1 164.0 91.0 79.1 REMARK 620 N 1 2 3 4 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-46044 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF DA03E17 FAB IN COMPLEX WITH INFLUENZA VIRUS REMARK 900 NEURAMINIDASE FROM B/COLORADO/06/2017 DBREF 9CYH H 1 217 PDB 9CYH 9CYH 1 217 DBREF 9CYH L 1 214 PDB 9CYH 9CYH 1 214 DBREF1 9CYH A 76 466 UNP A0A1X9RX69_9INFB DBREF2 9CYH A A0A1X9RX69 76 466 DBREF 9CYH E 1 217 PDB 9CYH 9CYH 1 217 DBREF 9CYH I 1 214 PDB 9CYH 9CYH 1 214 DBREF1 9CYH B 76 466 UNP A0A1X9RX69_9INFB DBREF2 9CYH B A0A1X9RX69 76 466 DBREF 9CYH F 1 217 PDB 9CYH 9CYH 1 217 DBREF 9CYH J 1 214 PDB 9CYH 9CYH 1 214 DBREF1 9CYH C 76 466 UNP A0A1X9RX69_9INFB DBREF2 9CYH C A0A1X9RX69 76 466 DBREF 9CYH G 1 217 PDB 9CYH 9CYH 1 217 DBREF 9CYH K 1 214 PDB 9CYH 9CYH 1 214 DBREF1 9CYH D 76 466 UNP A0A1X9RX69_9INFB DBREF2 9CYH D A0A1X9RX69 76 466 SEQADV 9CYH MET A -15 UNP A0A1X9RX6 INITIATING METHIONINE SEQADV 9CYH TYR A -14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A -13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH MET A -12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN A -11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A -10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA A -9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A -8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH CYS A -7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A -6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR A -5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A -4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR A -3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A -2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A -1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 0 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A 2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASN A 3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN A 5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS A 6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS A 7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS A 8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS A 9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS A 10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS A 11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY A 12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA A 14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TRP A 15 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 16 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS A 17 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO A 18 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN A 19 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE A 20 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 21 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS A 22 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY A 23 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY A 24 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 25 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 26 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 27 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP A 28 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TYR A 29 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 30 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP A 31 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 32 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN A 33 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG A 34 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A 35 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS A 36 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN A 37 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 38 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 39 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 40 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 41 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 42 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A 43 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS A 44 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS A 45 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 46 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 47 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN A 48 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS A 49 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A 50 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS A 51 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 52 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 53 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE A 54 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE A 55 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 56 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA A 57 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE A 58 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A 59 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN A 60 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU A 61 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 62 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG A 63 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS A 64 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG A 65 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY A 66 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 67 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU A 68 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL A 69 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO A 70 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG A 71 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY A 72 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER A 73 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY A 74 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY A 75 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH MET B -15 UNP A0A1X9RX6 INITIATING METHIONINE SEQADV 9CYH TYR B -14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B -13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH MET B -12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN B -11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B -10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA B -9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B -8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH CYS B -7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B -6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR B -5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B -4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR B -3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B -2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B -1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 0 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B 2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASN B 3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN B 5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS B 6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS B 7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS B 8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS B 9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS B 10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS B 11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY B 12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA B 14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TRP B 15 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 16 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS B 17 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO B 18 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN B 19 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE B 20 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 21 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS B 22 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY B 23 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY B 24 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 25 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 26 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 27 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP B 28 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TYR B 29 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 30 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP B 31 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 32 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN B 33 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG B 34 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B 35 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS B 36 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN B 37 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 38 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 39 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 40 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 41 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 42 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B 43 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS B 44 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS B 45 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 46 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 47 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN B 48 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS B 49 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B 50 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS B 51 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 52 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 53 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE B 54 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE B 55 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 56 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA B 57 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE B 58 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B 59 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN B 60 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU B 61 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 62 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG B 63 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS B 64 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG B 65 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY B 66 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 67 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU B 68 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL B 69 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO B 70 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG B 71 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY B 72 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER B 73 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY B 74 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY B 75 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH MET C -15 UNP A0A1X9RX6 INITIATING METHIONINE SEQADV 9CYH TYR C -14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C -13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH MET C -12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN C -11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C -10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA C -9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C -8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH CYS C -7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C -6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR C -5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C -4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR C -3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C -2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C -1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 0 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C 2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASN C 3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN C 5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS C 6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS C 7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS C 8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS C 9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS C 10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS C 11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY C 12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA C 14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TRP C 15 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 16 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS C 17 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO C 18 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN C 19 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE C 20 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 21 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS C 22 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY C 23 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY C 24 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 25 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 26 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 27 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP C 28 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TYR C 29 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 30 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP C 31 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 32 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN C 33 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG C 34 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C 35 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS C 36 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN C 37 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 38 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 39 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 40 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 41 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 42 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C 43 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS C 44 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS C 45 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 46 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 47 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN C 48 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS C 49 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C 50 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS C 51 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 52 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 53 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE C 54 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE C 55 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 56 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA C 57 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE C 58 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C 59 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN C 60 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU C 61 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 62 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG C 63 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS C 64 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG C 65 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY C 66 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 67 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU C 68 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL C 69 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO C 70 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG C 71 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY C 72 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER C 73 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY C 74 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY C 75 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH MET D -15 UNP A0A1X9RX6 INITIATING METHIONINE SEQADV 9CYH TYR D -14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D -13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH MET D -12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN D -11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D -10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA D -9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D -8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH CYS D -7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D -6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR D -5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D -4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH THR D -3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D -2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D -1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 0 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 1 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D 2 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASN D 3 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 4 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN D 5 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS D 6 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS D 7 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS D 8 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS D 9 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS D 10 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS D 11 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY D 12 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 13 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA D 14 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TRP D 15 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 16 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH HIS D 17 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO D 18 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN D 19 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE D 20 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 21 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS D 22 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY D 23 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY D 24 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 25 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 26 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 27 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP D 28 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH TYR D 29 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 30 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ASP D 31 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 32 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN D 33 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG D 34 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D 35 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS D 36 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN D 37 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 38 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 39 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 40 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 41 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 42 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D 43 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS D 44 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS D 45 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 46 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 47 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN D 48 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS D 49 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D 50 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS D 51 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 52 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 53 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE D 54 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ILE D 55 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 56 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ALA D 57 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PHE D 58 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D 59 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLN D 60 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLU D 61 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 62 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG D 63 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LYS D 64 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG D 65 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY D 66 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 67 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH LEU D 68 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH VAL D 69 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH PRO D 70 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH ARG D 71 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY D 72 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH SER D 73 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY D 74 UNP A0A1X9RX6 EXPRESSION TAG SEQADV 9CYH GLY D 75 UNP A0A1X9RX6 EXPRESSION TAG SEQRES 1 H 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 H 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 H 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 H 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 H 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 H 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 H 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 H 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 H 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 H 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 H 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 H 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 H 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 H 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 H 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 H 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 H 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 H 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 L 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 L 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 L 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 L 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 L 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 L 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 A 482 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 A 482 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 A 482 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 A 482 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 A 482 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 A 482 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 A 482 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 A 482 PRO GLU PRO GLU TRP THR TYR PRO ARG LEU SER CYS PRO SEQRES 9 A 482 GLY SER THR PHE GLN LYS ALA LEU LEU ILE SER PRO HIS SEQRES 10 A 482 ARG PHE GLY GLU THR LYS GLY ASN SER ALA PRO LEU ILE SEQRES 11 A 482 ILE ARG GLU PRO PHE VAL ALA CYS GLY PRO ASN GLU CYS SEQRES 12 A 482 LYS HIS PHE ALA LEU THR HIS TYR ALA ALA GLN PRO GLY SEQRES 13 A 482 GLY TYR TYR ASN GLY THR ARG GLY ASP ARG ASN LYS LEU SEQRES 14 A 482 ARG HIS LEU ILE SER VAL LYS LEU GLY LYS ILE PRO THR SEQRES 15 A 482 VAL GLU ASN SER ILE PHE HIS MET ALA ALA TRP SER GLY SEQRES 16 A 482 SER ALA CYS HIS ASP GLY LYS GLU TRP THR TYR ILE GLY SEQRES 17 A 482 VAL ASP GLY PRO ASP ASN ASN ALA LEU LEU LYS VAL LYS SEQRES 18 A 482 TYR GLY GLU ALA TYR THR ASP THR TYR HIS SER TYR ALA SEQRES 19 A 482 ASN ASN ILE LEU ARG THR GLN GLU SER ALA CYS ASN CYS SEQRES 20 A 482 ILE GLY GLY ASN CYS TYR LEU MET ILE THR ASP GLY SER SEQRES 21 A 482 ALA SER GLY VAL SER GLU CYS ARG PHE LEU LYS ILE ARG SEQRES 22 A 482 GLU GLY ARG ILE ILE LYS GLU ILE PHE PRO THR GLY ARG SEQRES 23 A 482 VAL LYS HIS THR GLU GLU CYS THR CYS GLY PHE ALA SER SEQRES 24 A 482 ASN LYS THR ILE GLU CYS ALA CYS ARG ASP ASN ARG TYR SEQRES 25 A 482 THR ALA LYS ARG PRO PHE VAL LYS LEU ASN VAL GLU THR SEQRES 26 A 482 ASP THR ALA GLU ILE ARG LEU MET CYS THR ASP THR TYR SEQRES 27 A 482 LEU ASP THR PRO ARG PRO ASN ASP GLY SER ILE THR GLY SEQRES 28 A 482 PRO CYS GLU SER ASP GLY ASP LYS GLY SER GLY GLY ILE SEQRES 29 A 482 LYS GLY GLY PHE VAL HIS GLN ARG MET LYS SER LYS ILE SEQRES 30 A 482 GLY ARG TRP TYR SER ARG THR MET SER GLN THR GLU ARG SEQRES 31 A 482 MET GLY MET GLY LEU TYR VAL LYS TYR GLY GLY ASP PRO SEQRES 32 A 482 TRP ALA ASP SER ASP ALA LEU ALA PHE SER GLY VAL MET SEQRES 33 A 482 VAL SER MET LYS GLU PRO GLY TRP TYR SER PHE GLY PHE SEQRES 34 A 482 GLU ILE LYS ASP LYS LYS CYS ASP VAL PRO CYS ILE GLY SEQRES 35 A 482 ILE GLU MET VAL HIS ASP GLY GLY LYS GLU THR TRP HIS SEQRES 36 A 482 SER ALA ALA THR ALA ILE TYR CYS LEU MET GLY SER GLY SEQRES 37 A 482 GLN LEU LEU TRP ASP THR VAL THR GLY VAL ASP MET ALA SEQRES 38 A 482 LEU SEQRES 1 E 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 E 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 E 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 E 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 E 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 E 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 E 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 E 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 E 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 E 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 E 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 E 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 E 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 E 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 E 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 E 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 E 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 E 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 I 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 I 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 I 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 I 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 I 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 I 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 I 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 I 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 I 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 I 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 I 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 I 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 I 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 I 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 I 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 I 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 I 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 B 482 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 B 482 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 B 482 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 B 482 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 B 482 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 B 482 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 B 482 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 B 482 PRO GLU PRO GLU TRP THR TYR PRO ARG LEU SER CYS PRO SEQRES 9 B 482 GLY SER THR PHE GLN LYS ALA LEU LEU ILE SER PRO HIS SEQRES 10 B 482 ARG PHE GLY GLU THR LYS GLY ASN SER ALA PRO LEU ILE SEQRES 11 B 482 ILE ARG GLU PRO PHE VAL ALA CYS GLY PRO ASN GLU CYS SEQRES 12 B 482 LYS HIS PHE ALA LEU THR HIS TYR ALA ALA GLN PRO GLY SEQRES 13 B 482 GLY TYR TYR ASN GLY THR ARG GLY ASP ARG ASN LYS LEU SEQRES 14 B 482 ARG HIS LEU ILE SER VAL LYS LEU GLY LYS ILE PRO THR SEQRES 15 B 482 VAL GLU ASN SER ILE PHE HIS MET ALA ALA TRP SER GLY SEQRES 16 B 482 SER ALA CYS HIS ASP GLY LYS GLU TRP THR TYR ILE GLY SEQRES 17 B 482 VAL ASP GLY PRO ASP ASN ASN ALA LEU LEU LYS VAL LYS SEQRES 18 B 482 TYR GLY GLU ALA TYR THR ASP THR TYR HIS SER TYR ALA SEQRES 19 B 482 ASN ASN ILE LEU ARG THR GLN GLU SER ALA CYS ASN CYS SEQRES 20 B 482 ILE GLY GLY ASN CYS TYR LEU MET ILE THR ASP GLY SER SEQRES 21 B 482 ALA SER GLY VAL SER GLU CYS ARG PHE LEU LYS ILE ARG SEQRES 22 B 482 GLU GLY ARG ILE ILE LYS GLU ILE PHE PRO THR GLY ARG SEQRES 23 B 482 VAL LYS HIS THR GLU GLU CYS THR CYS GLY PHE ALA SER SEQRES 24 B 482 ASN LYS THR ILE GLU CYS ALA CYS ARG ASP ASN ARG TYR SEQRES 25 B 482 THR ALA LYS ARG PRO PHE VAL LYS LEU ASN VAL GLU THR SEQRES 26 B 482 ASP THR ALA GLU ILE ARG LEU MET CYS THR ASP THR TYR SEQRES 27 B 482 LEU ASP THR PRO ARG PRO ASN ASP GLY SER ILE THR GLY SEQRES 28 B 482 PRO CYS GLU SER ASP GLY ASP LYS GLY SER GLY GLY ILE SEQRES 29 B 482 LYS GLY GLY PHE VAL HIS GLN ARG MET LYS SER LYS ILE SEQRES 30 B 482 GLY ARG TRP TYR SER ARG THR MET SER GLN THR GLU ARG SEQRES 31 B 482 MET GLY MET GLY LEU TYR VAL LYS TYR GLY GLY ASP PRO SEQRES 32 B 482 TRP ALA ASP SER ASP ALA LEU ALA PHE SER GLY VAL MET SEQRES 33 B 482 VAL SER MET LYS GLU PRO GLY TRP TYR SER PHE GLY PHE SEQRES 34 B 482 GLU ILE LYS ASP LYS LYS CYS ASP VAL PRO CYS ILE GLY SEQRES 35 B 482 ILE GLU MET VAL HIS ASP GLY GLY LYS GLU THR TRP HIS SEQRES 36 B 482 SER ALA ALA THR ALA ILE TYR CYS LEU MET GLY SER GLY SEQRES 37 B 482 GLN LEU LEU TRP ASP THR VAL THR GLY VAL ASP MET ALA SEQRES 38 B 482 LEU SEQRES 1 F 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 F 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 F 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 F 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 F 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 F 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 F 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 F 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 F 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 F 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 F 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 F 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 F 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 F 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 F 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 F 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 F 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 F 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 J 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 J 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 J 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 J 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 J 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 J 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 J 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 J 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 J 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 J 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 J 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 J 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 J 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 J 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 J 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 J 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 J 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 C 482 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 C 482 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 C 482 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 C 482 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 C 482 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 C 482 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 C 482 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 C 482 PRO GLU PRO GLU TRP THR TYR PRO ARG LEU SER CYS PRO SEQRES 9 C 482 GLY SER THR PHE GLN LYS ALA LEU LEU ILE SER PRO HIS SEQRES 10 C 482 ARG PHE GLY GLU THR LYS GLY ASN SER ALA PRO LEU ILE SEQRES 11 C 482 ILE ARG GLU PRO PHE VAL ALA CYS GLY PRO ASN GLU CYS SEQRES 12 C 482 LYS HIS PHE ALA LEU THR HIS TYR ALA ALA GLN PRO GLY SEQRES 13 C 482 GLY TYR TYR ASN GLY THR ARG GLY ASP ARG ASN LYS LEU SEQRES 14 C 482 ARG HIS LEU ILE SER VAL LYS LEU GLY LYS ILE PRO THR SEQRES 15 C 482 VAL GLU ASN SER ILE PHE HIS MET ALA ALA TRP SER GLY SEQRES 16 C 482 SER ALA CYS HIS ASP GLY LYS GLU TRP THR TYR ILE GLY SEQRES 17 C 482 VAL ASP GLY PRO ASP ASN ASN ALA LEU LEU LYS VAL LYS SEQRES 18 C 482 TYR GLY GLU ALA TYR THR ASP THR TYR HIS SER TYR ALA SEQRES 19 C 482 ASN ASN ILE LEU ARG THR GLN GLU SER ALA CYS ASN CYS SEQRES 20 C 482 ILE GLY GLY ASN CYS TYR LEU MET ILE THR ASP GLY SER SEQRES 21 C 482 ALA SER GLY VAL SER GLU CYS ARG PHE LEU LYS ILE ARG SEQRES 22 C 482 GLU GLY ARG ILE ILE LYS GLU ILE PHE PRO THR GLY ARG SEQRES 23 C 482 VAL LYS HIS THR GLU GLU CYS THR CYS GLY PHE ALA SER SEQRES 24 C 482 ASN LYS THR ILE GLU CYS ALA CYS ARG ASP ASN ARG TYR SEQRES 25 C 482 THR ALA LYS ARG PRO PHE VAL LYS LEU ASN VAL GLU THR SEQRES 26 C 482 ASP THR ALA GLU ILE ARG LEU MET CYS THR ASP THR TYR SEQRES 27 C 482 LEU ASP THR PRO ARG PRO ASN ASP GLY SER ILE THR GLY SEQRES 28 C 482 PRO CYS GLU SER ASP GLY ASP LYS GLY SER GLY GLY ILE SEQRES 29 C 482 LYS GLY GLY PHE VAL HIS GLN ARG MET LYS SER LYS ILE SEQRES 30 C 482 GLY ARG TRP TYR SER ARG THR MET SER GLN THR GLU ARG SEQRES 31 C 482 MET GLY MET GLY LEU TYR VAL LYS TYR GLY GLY ASP PRO SEQRES 32 C 482 TRP ALA ASP SER ASP ALA LEU ALA PHE SER GLY VAL MET SEQRES 33 C 482 VAL SER MET LYS GLU PRO GLY TRP TYR SER PHE GLY PHE SEQRES 34 C 482 GLU ILE LYS ASP LYS LYS CYS ASP VAL PRO CYS ILE GLY SEQRES 35 C 482 ILE GLU MET VAL HIS ASP GLY GLY LYS GLU THR TRP HIS SEQRES 36 C 482 SER ALA ALA THR ALA ILE TYR CYS LEU MET GLY SER GLY SEQRES 37 C 482 GLN LEU LEU TRP ASP THR VAL THR GLY VAL ASP MET ALA SEQRES 38 C 482 LEU SEQRES 1 G 231 GLU VAL GLN LEU VAL GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 G 231 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 G 231 GLY SER PHE SER SER GLY GLY TYR LEU TRP SER TRP VAL SEQRES 4 G 231 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 G 231 ILE LEU TYR SER GLY SER PRO TYR TYR ASN PRO SER LEU SEQRES 6 G 231 GLU SER ARG ALA THR ILE SER LEU ASP THR SER LYS ASN SEQRES 7 G 231 GLN PHE SER LEU ARG LEU ILE SER VAL THR ALA ALA ASP SEQRES 8 G 231 ALA ALA MET TYR TYR CYS ALA ARG VAL ASP GLY SER GLY SEQRES 9 G 231 ASN THR ASP ARG TYR TYR PHE TYR GLY MET ASP VAL TRP SEQRES 10 G 231 GLY GLN GLY THR MET VAL THR VAL SER SER ALA SER THR SEQRES 11 G 231 LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SEQRES 12 G 231 SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL SEQRES 13 G 231 LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SEQRES 14 G 231 SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA SEQRES 15 G 231 VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL SEQRES 16 G 231 VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR SEQRES 17 G 231 ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL SEQRES 18 G 231 ASP LYS ARG VAL GLU PRO LYS SER CYS ASP SEQRES 1 K 215 ASP ILE GLN MET THR GLN SER PRO SER SER VAL SER ALA SEQRES 2 K 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 K 215 ARG GLY ILE GLY ASP TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 K 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 K 215 SER LEU GLN ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 K 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 K 215 GLN PRO ASP ASP PHE ALA THR TYR TYR CYS GLN GLN ALA SEQRES 8 K 215 ASP GLY TRP GLU VAL TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 K 215 VAL ASP VAL LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 K 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 K 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 K 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 K 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 K 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 K 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 K 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 K 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 D 482 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 D 482 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 D 482 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 D 482 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 D 482 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 D 482 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 D 482 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 D 482 PRO GLU PRO GLU TRP THR TYR PRO ARG LEU SER CYS PRO SEQRES 9 D 482 GLY SER THR PHE GLN LYS ALA LEU LEU ILE SER PRO HIS SEQRES 10 D 482 ARG PHE GLY GLU THR LYS GLY ASN SER ALA PRO LEU ILE SEQRES 11 D 482 ILE ARG GLU PRO PHE VAL ALA CYS GLY PRO ASN GLU CYS SEQRES 12 D 482 LYS HIS PHE ALA LEU THR HIS TYR ALA ALA GLN PRO GLY SEQRES 13 D 482 GLY TYR TYR ASN GLY THR ARG GLY ASP ARG ASN LYS LEU SEQRES 14 D 482 ARG HIS LEU ILE SER VAL LYS LEU GLY LYS ILE PRO THR SEQRES 15 D 482 VAL GLU ASN SER ILE PHE HIS MET ALA ALA TRP SER GLY SEQRES 16 D 482 SER ALA CYS HIS ASP GLY LYS GLU TRP THR TYR ILE GLY SEQRES 17 D 482 VAL ASP GLY PRO ASP ASN ASN ALA LEU LEU LYS VAL LYS SEQRES 18 D 482 TYR GLY GLU ALA TYR THR ASP THR TYR HIS SER TYR ALA SEQRES 19 D 482 ASN ASN ILE LEU ARG THR GLN GLU SER ALA CYS ASN CYS SEQRES 20 D 482 ILE GLY GLY ASN CYS TYR LEU MET ILE THR ASP GLY SER SEQRES 21 D 482 ALA SER GLY VAL SER GLU CYS ARG PHE LEU LYS ILE ARG SEQRES 22 D 482 GLU GLY ARG ILE ILE LYS GLU ILE PHE PRO THR GLY ARG SEQRES 23 D 482 VAL LYS HIS THR GLU GLU CYS THR CYS GLY PHE ALA SER SEQRES 24 D 482 ASN LYS THR ILE GLU CYS ALA CYS ARG ASP ASN ARG TYR SEQRES 25 D 482 THR ALA LYS ARG PRO PHE VAL LYS LEU ASN VAL GLU THR SEQRES 26 D 482 ASP THR ALA GLU ILE ARG LEU MET CYS THR ASP THR TYR SEQRES 27 D 482 LEU ASP THR PRO ARG PRO ASN ASP GLY SER ILE THR GLY SEQRES 28 D 482 PRO CYS GLU SER ASP GLY ASP LYS GLY SER GLY GLY ILE SEQRES 29 D 482 LYS GLY GLY PHE VAL HIS GLN ARG MET LYS SER LYS ILE SEQRES 30 D 482 GLY ARG TRP TYR SER ARG THR MET SER GLN THR GLU ARG SEQRES 31 D 482 MET GLY MET GLY LEU TYR VAL LYS TYR GLY GLY ASP PRO SEQRES 32 D 482 TRP ALA ASP SER ASP ALA LEU ALA PHE SER GLY VAL MET SEQRES 33 D 482 VAL SER MET LYS GLU PRO GLY TRP TYR SER PHE GLY PHE SEQRES 34 D 482 GLU ILE LYS ASP LYS LYS CYS ASP VAL PRO CYS ILE GLY SEQRES 35 D 482 ILE GLU MET VAL HIS ASP GLY GLY LYS GLU THR TRP HIS SEQRES 36 D 482 SER ALA ALA THR ALA ILE TYR CYS LEU MET GLY SER GLY SEQRES 37 D 482 GLN LEU LEU TRP ASP THR VAL THR GLY VAL ASP MET ALA SEQRES 38 D 482 LEU HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET CA A 501 1 HET CA B 501 1 HET CA C 501 1 HET CA D 501 1 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM CA CALCIUM ION HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 13 NAG 16(C8 H15 N O6) FORMUL 21 CA 4(CA 2+) HELIX 1 AA1 PRO H 61 GLU H 64 5 4 HELIX 2 AA2 SER A 99 GLY A 104 5 6 HELIX 3 AA3 PRO E 61 GLU E 64 5 4 HELIX 4 AA4 SER B 99 GLY B 104 5 6 HELIX 5 AA5 PRO F 61 GLU F 64 5 4 HELIX 6 AA6 SER C 99 GLY C 104 5 6 HELIX 7 AA7 PRO G 61 GLU G 64 5 4 HELIX 8 AA8 SER D 99 GLY D 104 5 6 SHEET 1 AA1 9 TYR H 58 TYR H 59 0 SHEET 2 AA1 9 LEU H 45 ILE H 51 -1 N TYR H 50 O TYR H 58 SHEET 3 AA1 9 LEU H 35 GLN H 39 -1 N ARG H 38 O GLU H 46 SHEET 4 AA1 9 MET H 89 VAL H 95 -1 O VAL H 95 N LEU H 35 SHEET 5 AA1 9 VAL H 102 GLN H 105 -1 O VAL H 102 N ARG H 94 SHEET 6 AA1 9 GLN H 3 SER H 7 1 N LEU H 4 O GLN H 105 SHEET 7 AA1 9 LEU H 18 SER H 25 -1 O THR H 21 N SER H 7 SHEET 8 AA1 9 GLN H 77 LEU H 82 -1 O LEU H 82 N LEU H 18 SHEET 9 AA1 9 ALA H 67 ASP H 72 -1 N SER H 70 O SER H 79 SHEET 1 AA2 5 TYR H 58 TYR H 59 0 SHEET 2 AA2 5 LEU H 45 ILE H 51 -1 N TYR H 50 O TYR H 58 SHEET 3 AA2 5 LEU H 35 GLN H 39 -1 N ARG H 38 O GLU H 46 SHEET 4 AA2 5 MET H 89 VAL H 95 -1 O VAL H 95 N LEU H 35 SHEET 5 AA2 5 THR H 107 MET H 108 -1 O THR H 107 N TYR H 90 SHEET 1 AA3 2 LEU H 11 VAL H 12 0 SHEET 2 AA3 2 THR H 110 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 1 AA4 4 MET L 4 GLN L 6 0 SHEET 2 AA4 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AA4 4 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AA4 4 GLY L 64 SER L 67 -1 N SER L 67 O ASP L 70 SHEET 1 AA5 6 SER L 10 ALA L 13 0 SHEET 2 AA5 6 THR L 102 VAL L 106 1 O ASP L 105 N ALA L 13 SHEET 3 AA5 6 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AA5 6 LEU L 33 GLN L 38 -1 N GLN L 38 O THR L 85 SHEET 5 AA5 6 LYS L 45 TYR L 49 -1 O LEU L 47 N TRP L 35 SHEET 6 AA5 6 SER L 53 LEU L 54 -1 O SER L 53 N TYR L 49 SHEET 1 AA6 4 SER L 10 ALA L 13 0 SHEET 2 AA6 4 THR L 102 VAL L 106 1 O ASP L 105 N ALA L 13 SHEET 3 AA6 4 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AA6 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AA7 4 PHE A 92 ILE A 98 0 SHEET 2 AA7 4 ALA A 441 LEU A 448 -1 O THR A 443 N ILE A 98 SHEET 3 AA7 4 ASP A 421 VAL A 430 -1 N ILE A 425 O TYR A 446 SHEET 4 AA7 4 SER A 410 LYS A 416 -1 N ILE A 415 O VAL A 422 SHEET 1 AA8 4 LEU A 113 CYS A 122 0 SHEET 2 AA8 4 CYS A 127 ALA A 137 -1 O PHE A 130 N PHE A 119 SHEET 3 AA8 4 HIS A 155 LYS A 160 -1 O VAL A 159 N HIS A 129 SHEET 4 AA8 4 ILE A 171 ALA A 175 -1 O HIS A 173 N LEU A 156 SHEET 1 AA9 4 SER A 178 HIS A 183 0 SHEET 2 AA9 4 TRP A 188 VAL A 193 -1 O ILE A 191 N SER A 180 SHEET 3 AA9 4 LEU A 201 TYR A 206 -1 O LYS A 205 N TYR A 190 SHEET 4 AA9 4 ALA A 209 HIS A 215 -1 O TYR A 214 N LEU A 202 SHEET 1 AB1 3 ARG A 223 THR A 224 0 SHEET 2 AB1 3 ASN A 235 THR A 241 -1 O THR A 241 N ARG A 223 SHEET 3 AB1 3 ASN A 230 ILE A 232 -1 N ASN A 230 O TYR A 237 SHEET 1 AB2 4 ARG A 223 THR A 224 0 SHEET 2 AB2 4 ASN A 235 THR A 241 -1 O THR A 241 N ARG A 223 SHEET 3 AB2 4 CYS A 251 ARG A 257 -1 O ILE A 256 N CYS A 236 SHEET 4 AB2 4 ARG A 260 ILE A 265 -1 O ILE A 265 N PHE A 253 SHEET 1 AB3 5 THR A 268 GLY A 269 0 SHEET 2 AB3 5 THR A 311 LEU A 316 1 O ILE A 314 N THR A 268 SHEET 3 AB3 5 PRO A 301 ASN A 306 -1 N ASN A 306 O THR A 311 SHEET 4 AB3 5 THR A 286 ARG A 292 -1 N ILE A 287 O LEU A 305 SHEET 5 AB3 5 GLU A 275 PHE A 281 -1 N THR A 278 O ALA A 290 SHEET 1 AB4 4 PHE A 352 ARG A 356 0 SHEET 2 AB4 4 ILE A 361 ARG A 367 -1 O GLY A 362 N GLN A 355 SHEET 3 AB4 4 MET A 375 LYS A 382 -1 O GLY A 378 N ARG A 367 SHEET 4 AB4 4 ALA A 395 PRO A 406 -1 O SER A 397 N LEU A 379 SHEET 1 AB5 9 TYR E 58 TYR E 59 0 SHEET 2 AB5 9 LEU E 45 ILE E 51 -1 N TYR E 50 O TYR E 58 SHEET 3 AB5 9 LEU E 35 GLN E 39 -1 N ARG E 38 O GLU E 46 SHEET 4 AB5 9 MET E 89 VAL E 95 -1 O VAL E 95 N LEU E 35 SHEET 5 AB5 9 VAL E 102 GLN E 105 -1 O VAL E 102 N ARG E 94 SHEET 6 AB5 9 GLN E 3 SER E 7 1 N LEU E 4 O GLN E 105 SHEET 7 AB5 9 LEU E 18 SER E 25 -1 O THR E 21 N SER E 7 SHEET 8 AB5 9 GLN E 77 LEU E 82 -1 O LEU E 82 N LEU E 18 SHEET 9 AB5 9 ALA E 67 ASP E 72 -1 N SER E 70 O SER E 79 SHEET 1 AB6 5 TYR E 58 TYR E 59 0 SHEET 2 AB6 5 LEU E 45 ILE E 51 -1 N TYR E 50 O TYR E 58 SHEET 3 AB6 5 LEU E 35 GLN E 39 -1 N ARG E 38 O GLU E 46 SHEET 4 AB6 5 MET E 89 VAL E 95 -1 O VAL E 95 N LEU E 35 SHEET 5 AB6 5 THR E 107 MET E 108 -1 O THR E 107 N TYR E 90 SHEET 1 AB7 2 LEU E 11 VAL E 12 0 SHEET 2 AB7 2 THR E 110 VAL E 111 1 O THR E 110 N VAL E 12 SHEET 1 AB8 4 MET I 4 GLN I 6 0 SHEET 2 AB8 4 VAL I 19 ALA I 25 -1 O ARG I 24 N THR I 5 SHEET 3 AB8 4 ASP I 70 ILE I 75 -1 O LEU I 73 N ILE I 21 SHEET 4 AB8 4 GLY I 64 SER I 67 -1 N SER I 67 O ASP I 70 SHEET 1 AB9 6 SER I 10 ALA I 13 0 SHEET 2 AB9 6 THR I 102 VAL I 106 1 O ASP I 105 N ALA I 13 SHEET 3 AB9 6 THR I 85 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AB9 6 LEU I 33 GLN I 38 -1 N GLN I 38 O THR I 85 SHEET 5 AB9 6 LYS I 45 TYR I 49 -1 O LEU I 47 N TRP I 35 SHEET 6 AB9 6 SER I 53 LEU I 54 -1 O SER I 53 N TYR I 49 SHEET 1 AC1 4 SER I 10 ALA I 13 0 SHEET 2 AC1 4 THR I 102 VAL I 106 1 O ASP I 105 N ALA I 13 SHEET 3 AC1 4 THR I 85 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AC1 4 THR I 97 PHE I 98 -1 O THR I 97 N GLN I 90 SHEET 1 AC2 4 PHE B 92 ILE B 98 0 SHEET 2 AC2 4 ALA B 441 LEU B 448 -1 O THR B 443 N ILE B 98 SHEET 3 AC2 4 ASP B 421 VAL B 430 -1 N ILE B 425 O TYR B 446 SHEET 4 AC2 4 SER B 410 LYS B 416 -1 N ILE B 415 O VAL B 422 SHEET 1 AC3 4 LEU B 113 CYS B 122 0 SHEET 2 AC3 4 CYS B 127 ALA B 137 -1 O PHE B 130 N PHE B 119 SHEET 3 AC3 4 HIS B 155 LYS B 160 -1 O VAL B 159 N HIS B 129 SHEET 4 AC3 4 ILE B 171 ALA B 175 -1 O HIS B 173 N LEU B 156 SHEET 1 AC4 4 SER B 178 HIS B 183 0 SHEET 2 AC4 4 TRP B 188 VAL B 193 -1 O ILE B 191 N SER B 180 SHEET 3 AC4 4 LEU B 201 TYR B 206 -1 O LYS B 205 N TYR B 190 SHEET 4 AC4 4 ALA B 209 HIS B 215 -1 O TYR B 214 N LEU B 202 SHEET 1 AC5 3 ARG B 223 THR B 224 0 SHEET 2 AC5 3 ASN B 235 THR B 241 -1 O THR B 241 N ARG B 223 SHEET 3 AC5 3 ASN B 230 ILE B 232 -1 N ASN B 230 O TYR B 237 SHEET 1 AC6 4 ARG B 223 THR B 224 0 SHEET 2 AC6 4 ASN B 235 THR B 241 -1 O THR B 241 N ARG B 223 SHEET 3 AC6 4 CYS B 251 ARG B 257 -1 O ILE B 256 N CYS B 236 SHEET 4 AC6 4 ARG B 260 ILE B 265 -1 O ILE B 265 N PHE B 253 SHEET 1 AC7 5 THR B 268 GLY B 269 0 SHEET 2 AC7 5 THR B 311 LEU B 316 1 O ILE B 314 N THR B 268 SHEET 3 AC7 5 PRO B 301 ASN B 306 -1 N ASN B 306 O THR B 311 SHEET 4 AC7 5 THR B 286 ARG B 292 -1 N ILE B 287 O LEU B 305 SHEET 5 AC7 5 GLU B 275 PHE B 281 -1 N THR B 278 O ALA B 290 SHEET 1 AC8 4 PHE B 352 ARG B 356 0 SHEET 2 AC8 4 ILE B 361 ARG B 367 -1 O GLY B 362 N GLN B 355 SHEET 3 AC8 4 MET B 375 LYS B 382 -1 O GLY B 378 N ARG B 367 SHEET 4 AC8 4 ALA B 395 PRO B 406 -1 O SER B 397 N LEU B 379 SHEET 1 AC9 9 TYR F 58 TYR F 59 0 SHEET 2 AC9 9 LEU F 45 ILE F 51 -1 N TYR F 50 O TYR F 58 SHEET 3 AC9 9 LEU F 35 GLN F 39 -1 N ARG F 38 O GLU F 46 SHEET 4 AC9 9 MET F 89 VAL F 95 -1 O VAL F 95 N LEU F 35 SHEET 5 AC9 9 VAL F 102 GLN F 105 -1 O VAL F 102 N ARG F 94 SHEET 6 AC9 9 GLN F 3 SER F 7 1 N LEU F 4 O GLN F 105 SHEET 7 AC9 9 LEU F 18 SER F 25 -1 O THR F 21 N SER F 7 SHEET 8 AC9 9 GLN F 77 LEU F 82 -1 O LEU F 82 N LEU F 18 SHEET 9 AC9 9 ALA F 67 ASP F 72 -1 N SER F 70 O SER F 79 SHEET 1 AD1 5 TYR F 58 TYR F 59 0 SHEET 2 AD1 5 LEU F 45 ILE F 51 -1 N TYR F 50 O TYR F 58 SHEET 3 AD1 5 LEU F 35 GLN F 39 -1 N ARG F 38 O GLU F 46 SHEET 4 AD1 5 MET F 89 VAL F 95 -1 O VAL F 95 N LEU F 35 SHEET 5 AD1 5 THR F 107 MET F 108 -1 O THR F 107 N TYR F 90 SHEET 1 AD2 2 LEU F 11 VAL F 12 0 SHEET 2 AD2 2 THR F 110 VAL F 111 1 O THR F 110 N VAL F 12 SHEET 1 AD3 4 MET J 4 GLN J 6 0 SHEET 2 AD3 4 VAL J 19 ALA J 25 -1 O ARG J 24 N THR J 5 SHEET 3 AD3 4 ASP J 70 ILE J 75 -1 O LEU J 73 N ILE J 21 SHEET 4 AD3 4 GLY J 64 SER J 67 -1 N SER J 67 O ASP J 70 SHEET 1 AD4 6 SER J 10 ALA J 13 0 SHEET 2 AD4 6 THR J 102 VAL J 106 1 O ASP J 105 N ALA J 13 SHEET 3 AD4 6 THR J 85 GLN J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AD4 6 LEU J 33 GLN J 38 -1 N GLN J 38 O THR J 85 SHEET 5 AD4 6 LYS J 45 TYR J 49 -1 O LEU J 47 N TRP J 35 SHEET 6 AD4 6 SER J 53 LEU J 54 -1 O SER J 53 N TYR J 49 SHEET 1 AD5 4 SER J 10 ALA J 13 0 SHEET 2 AD5 4 THR J 102 VAL J 106 1 O ASP J 105 N ALA J 13 SHEET 3 AD5 4 THR J 85 GLN J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AD5 4 THR J 97 PHE J 98 -1 O THR J 97 N GLN J 90 SHEET 1 AD6 4 PHE C 92 ILE C 98 0 SHEET 2 AD6 4 ALA C 441 LEU C 448 -1 O THR C 443 N ILE C 98 SHEET 3 AD6 4 ASP C 421 VAL C 430 -1 N ILE C 425 O TYR C 446 SHEET 4 AD6 4 SER C 410 LYS C 416 -1 N ILE C 415 O VAL C 422 SHEET 1 AD7 4 LEU C 113 CYS C 122 0 SHEET 2 AD7 4 CYS C 127 ALA C 137 -1 O PHE C 130 N PHE C 119 SHEET 3 AD7 4 HIS C 155 LYS C 160 -1 O VAL C 159 N HIS C 129 SHEET 4 AD7 4 ILE C 171 ALA C 175 -1 O HIS C 173 N LEU C 156 SHEET 1 AD8 4 SER C 178 HIS C 183 0 SHEET 2 AD8 4 TRP C 188 VAL C 193 -1 O ILE C 191 N SER C 180 SHEET 3 AD8 4 LEU C 201 TYR C 206 -1 O LYS C 205 N TYR C 190 SHEET 4 AD8 4 ALA C 209 HIS C 215 -1 O TYR C 214 N LEU C 202 SHEET 1 AD9 3 ARG C 223 THR C 224 0 SHEET 2 AD9 3 ASN C 235 THR C 241 -1 O THR C 241 N ARG C 223 SHEET 3 AD9 3 ASN C 230 ILE C 232 -1 N ASN C 230 O TYR C 237 SHEET 1 AE1 4 ARG C 223 THR C 224 0 SHEET 2 AE1 4 ASN C 235 THR C 241 -1 O THR C 241 N ARG C 223 SHEET 3 AE1 4 CYS C 251 ARG C 257 -1 O ILE C 256 N CYS C 236 SHEET 4 AE1 4 ARG C 260 ILE C 265 -1 O ILE C 265 N PHE C 253 SHEET 1 AE2 5 THR C 268 GLY C 269 0 SHEET 2 AE2 5 THR C 311 LEU C 316 1 O ILE C 314 N THR C 268 SHEET 3 AE2 5 PRO C 301 ASN C 306 -1 N ASN C 306 O THR C 311 SHEET 4 AE2 5 THR C 286 ARG C 292 -1 N ILE C 287 O LEU C 305 SHEET 5 AE2 5 GLU C 275 PHE C 281 -1 N THR C 278 O ALA C 290 SHEET 1 AE3 4 PHE C 352 ARG C 356 0 SHEET 2 AE3 4 ILE C 361 ARG C 367 -1 O GLY C 362 N GLN C 355 SHEET 3 AE3 4 MET C 375 LYS C 382 -1 O GLY C 378 N ARG C 367 SHEET 4 AE3 4 ALA C 395 PRO C 406 -1 O SER C 397 N LEU C 379 SHEET 1 AE4 9 TYR G 58 TYR G 59 0 SHEET 2 AE4 9 LEU G 45 ILE G 51 -1 N TYR G 50 O TYR G 58 SHEET 3 AE4 9 LEU G 35 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 4 AE4 9 MET G 89 VAL G 95 -1 O VAL G 95 N LEU G 35 SHEET 5 AE4 9 VAL G 102 GLN G 105 -1 O VAL G 102 N ARG G 94 SHEET 6 AE4 9 GLN G 3 SER G 7 1 N LEU G 4 O GLN G 105 SHEET 7 AE4 9 LEU G 18 SER G 25 -1 O THR G 21 N SER G 7 SHEET 8 AE4 9 GLN G 77 LEU G 82 -1 O LEU G 82 N LEU G 18 SHEET 9 AE4 9 ALA G 67 ASP G 72 -1 N SER G 70 O SER G 79 SHEET 1 AE5 5 TYR G 58 TYR G 59 0 SHEET 2 AE5 5 LEU G 45 ILE G 51 -1 N TYR G 50 O TYR G 58 SHEET 3 AE5 5 LEU G 35 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 4 AE5 5 MET G 89 VAL G 95 -1 O VAL G 95 N LEU G 35 SHEET 5 AE5 5 THR G 107 MET G 108 -1 O THR G 107 N TYR G 90 SHEET 1 AE6 2 LEU G 11 VAL G 12 0 SHEET 2 AE6 2 THR G 110 VAL G 111 1 O THR G 110 N VAL G 12 SHEET 1 AE7 4 MET K 4 GLN K 6 0 SHEET 2 AE7 4 VAL K 19 ALA K 25 -1 O ARG K 24 N THR K 5 SHEET 3 AE7 4 ASP K 70 ILE K 75 -1 O LEU K 73 N ILE K 21 SHEET 4 AE7 4 GLY K 64 SER K 67 -1 N SER K 67 O ASP K 70 SHEET 1 AE8 6 SER K 10 ALA K 13 0 SHEET 2 AE8 6 THR K 102 VAL K 106 1 O ASP K 105 N ALA K 13 SHEET 3 AE8 6 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AE8 6 LEU K 33 GLN K 38 -1 N GLN K 38 O THR K 85 SHEET 5 AE8 6 LYS K 45 TYR K 49 -1 O LEU K 47 N TRP K 35 SHEET 6 AE8 6 SER K 53 LEU K 54 -1 O SER K 53 N TYR K 49 SHEET 1 AE9 4 SER K 10 ALA K 13 0 SHEET 2 AE9 4 THR K 102 VAL K 106 1 O ASP K 105 N ALA K 13 SHEET 3 AE9 4 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AE9 4 THR K 97 PHE K 98 -1 O THR K 97 N GLN K 90 SHEET 1 AF1 4 PHE D 92 ILE D 98 0 SHEET 2 AF1 4 ALA D 441 LEU D 448 -1 O THR D 443 N ILE D 98 SHEET 3 AF1 4 ASP D 421 VAL D 430 -1 N ILE D 425 O TYR D 446 SHEET 4 AF1 4 SER D 410 LYS D 416 -1 N ILE D 415 O VAL D 422 SHEET 1 AF2 4 LEU D 113 CYS D 122 0 SHEET 2 AF2 4 CYS D 127 ALA D 137 -1 O PHE D 130 N PHE D 119 SHEET 3 AF2 4 HIS D 155 LYS D 160 -1 O VAL D 159 N HIS D 129 SHEET 4 AF2 4 ILE D 171 ALA D 175 -1 O HIS D 173 N LEU D 156 SHEET 1 AF3 4 SER D 178 HIS D 183 0 SHEET 2 AF3 4 TRP D 188 VAL D 193 -1 O ILE D 191 N SER D 180 SHEET 3 AF3 4 LEU D 201 TYR D 206 -1 O LYS D 205 N TYR D 190 SHEET 4 AF3 4 ALA D 209 HIS D 215 -1 O TYR D 214 N LEU D 202 SHEET 1 AF4 3 ARG D 223 THR D 224 0 SHEET 2 AF4 3 ASN D 235 THR D 241 -1 O THR D 241 N ARG D 223 SHEET 3 AF4 3 ASN D 230 ILE D 232 -1 N ASN D 230 O TYR D 237 SHEET 1 AF5 4 ARG D 223 THR D 224 0 SHEET 2 AF5 4 ASN D 235 THR D 241 -1 O THR D 241 N ARG D 223 SHEET 3 AF5 4 CYS D 251 ARG D 257 -1 O ILE D 256 N CYS D 236 SHEET 4 AF5 4 ARG D 260 ILE D 265 -1 O ILE D 265 N PHE D 253 SHEET 1 AF6 5 THR D 268 GLY D 269 0 SHEET 2 AF6 5 THR D 311 LEU D 316 1 O ILE D 314 N THR D 268 SHEET 3 AF6 5 PRO D 301 ASN D 306 -1 N ASN D 306 O THR D 311 SHEET 4 AF6 5 THR D 286 ARG D 292 -1 N ILE D 287 O LEU D 305 SHEET 5 AF6 5 GLU D 275 PHE D 281 -1 N THR D 278 O ALA D 290 SHEET 1 AF7 4 PHE D 352 ARG D 356 0 SHEET 2 AF7 4 ILE D 361 ARG D 367 -1 O GLY D 362 N GLN D 355 SHEET 3 AF7 4 MET D 375 LYS D 382 -1 O GLY D 378 N ARG D 367 SHEET 4 AF7 4 ALA D 395 PRO D 406 -1 O SER D 397 N LEU D 379 SSBOND 1 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 2 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 3 CYS A 87 CYS A 420 1555 1555 2.03 SSBOND 4 CYS A 122 CYS A 127 1555 1555 2.03 SSBOND 5 CYS A 182 CYS A 229 1555 1555 2.03 SSBOND 6 CYS A 231 CYS A 236 1555 1555 2.03 SSBOND 7 CYS A 277 CYS A 291 1555 1555 2.03 SSBOND 8 CYS A 279 CYS A 289 1555 1555 2.03 SSBOND 9 CYS A 318 CYS A 337 1555 1555 2.03 SSBOND 10 CYS A 424 CYS A 447 1555 1555 2.03 SSBOND 11 CYS E 22 CYS E 92 1555 1555 2.03 SSBOND 12 CYS I 23 CYS I 88 1555 1555 2.04 SSBOND 13 CYS B 87 CYS B 420 1555 1555 2.03 SSBOND 14 CYS B 122 CYS B 127 1555 1555 2.03 SSBOND 15 CYS B 182 CYS B 229 1555 1555 2.03 SSBOND 16 CYS B 231 CYS B 236 1555 1555 2.03 SSBOND 17 CYS B 277 CYS B 291 1555 1555 2.03 SSBOND 18 CYS B 279 CYS B 289 1555 1555 2.03 SSBOND 19 CYS B 318 CYS B 337 1555 1555 2.03 SSBOND 20 CYS B 424 CYS B 447 1555 1555 2.03 SSBOND 21 CYS F 22 CYS F 92 1555 1555 2.03 SSBOND 22 CYS J 23 CYS J 88 1555 1555 2.04 SSBOND 23 CYS C 87 CYS C 420 1555 1555 2.03 SSBOND 24 CYS C 122 CYS C 127 1555 1555 2.03 SSBOND 25 CYS C 182 CYS C 229 1555 1555 2.03 SSBOND 26 CYS C 231 CYS C 236 1555 1555 2.03 SSBOND 27 CYS C 277 CYS C 291 1555 1555 2.03 SSBOND 28 CYS C 279 CYS C 289 1555 1555 2.03 SSBOND 29 CYS C 318 CYS C 337 1555 1555 2.03 SSBOND 30 CYS C 424 CYS C 447 1555 1555 2.03 SSBOND 31 CYS G 22 CYS G 92 1555 1555 2.03 SSBOND 32 CYS K 23 CYS K 88 1555 1555 2.04 SSBOND 33 CYS D 87 CYS D 420 1555 1555 2.03 SSBOND 34 CYS D 122 CYS D 127 1555 1555 2.03 SSBOND 35 CYS D 182 CYS D 229 1555 1555 2.03 SSBOND 36 CYS D 231 CYS D 236 1555 1555 2.03 SSBOND 37 CYS D 277 CYS D 291 1555 1555 2.03 SSBOND 38 CYS D 279 CYS D 289 1555 1555 2.03 SSBOND 39 CYS D 318 CYS D 337 1555 1555 2.03 SSBOND 40 CYS D 424 CYS D 447 1555 1555 2.03 LINK ND2 ASN A 144 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN A 284 C1 NAG N 1 1555 1555 1.45 LINK ND2 ASN B 144 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN B 284 C1 NAG P 1 1555 1555 1.45 LINK ND2 ASN C 144 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN C 284 C1 NAG R 1 1555 1555 1.45 LINK ND2 ASN D 144 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN D 284 C1 NAG T 1 1555 1555 1.45 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O ASP A 293 CA CA A 501 1555 1555 2.30 LINK O THR A 297 CA CA A 501 1555 1555 2.27 LINK OD2 ASP A 324 CA CA A 501 1555 1555 2.27 LINK O GLY A 344 CA CA A 501 1555 1555 2.37 LINK O GLY A 346 CA CA A 501 1555 1555 2.26 LINK O ASP B 293 CA CA B 501 1555 1555 2.30 LINK O THR B 297 CA CA B 501 1555 1555 2.27 LINK OD2 ASP B 324 CA CA B 501 1555 1555 2.27 LINK O GLY B 344 CA CA B 501 1555 1555 2.37 LINK O GLY B 346 CA CA B 501 1555 1555 2.26 LINK O ASP C 293 CA CA C 501 1555 1555 2.30 LINK O THR C 297 CA CA C 501 1555 1555 2.27 LINK OD2 ASP C 324 CA CA C 501 1555 1555 2.27 LINK O GLY C 344 CA CA C 501 1555 1555 2.37 LINK O GLY C 346 CA CA C 501 1555 1555 2.26 LINK O ASP D 293 CA CA D 501 1555 1555 2.30 LINK O THR D 297 CA CA D 501 1555 1555 2.27 LINK OD2 ASP D 324 CA CA D 501 1555 1555 2.27 LINK O GLY D 344 CA CA D 501 1555 1555 2.37 LINK O GLY D 346 CA CA D 501 1555 1555 2.26 CISPEP 1 GLN A 138 PRO A 139 0 0.94 CISPEP 2 THR A 325 PRO A 326 0 -0.57 CISPEP 3 GLN B 138 PRO B 139 0 0.99 CISPEP 4 THR B 325 PRO B 326 0 -0.38 CISPEP 5 GLN C 138 PRO C 139 0 1.01 CISPEP 6 THR C 325 PRO C 326 0 -0.47 CISPEP 7 GLN D 138 PRO D 139 0 0.98 CISPEP 8 THR D 325 PRO D 326 0 -0.54 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000