HEADER VIRAL PROTEIN/IMMUNE SYSTEM 02-AUG-24 9CYJ TITLE CRYO-EM STRUCTURE OF FNI9 IGG IN COMPLEX WITH INFLUENZA VIRUS TITLE 2 NEURAMINIDASE FROM A/KANSAS/14/2017 (H3N2) COMPND MOL_ID: 1; COMPND 2 MOLECULE: NEURAMINIDASE; COMPND 3 CHAIN: C, B, A, D; COMPND 4 EC: 3.2.1.18; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: FNI9 IGG HEAVY CHAIN; COMPND 8 CHAIN: H; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: FNI9 IGG LIGHT CHAIN; COMPND 12 CHAIN: L; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 11320; SOURCE 4 GENE: NA; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS NEURAMINIDASE, HYDROLASE, ANTIBODY COMPLEX, VIRAL PROTEIN, VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.JO,J.HAN,J.L.TORRES,J.A.FERGUSON,A.B.WARD REVDAT 1 13-AUG-25 9CYJ 0 JRNL AUTH G.JO,S.YAMAYOSHI,K.M.MA,O.SWANSON,J.L.TORRES,J.A.FERGUSON, JRNL AUTH 2 M.L.FERNANDEZ-QUINTERO,J.HUANG,J.COPPS,A.J.RODRIGUEZ, JRNL AUTH 3 J.M.STEICHEN,Y.KAWAOKA,J.HAN,A.B.WARD JRNL TITL STRUCTURAL BASIS OF BROAD PROTECTION AGAINST INFLUENZA VIRUS JRNL TITL 2 BY HUMAN ANTIBODIES TARGETING THE NEURAMINIDASE ACTIVE SITE JRNL TITL 3 VIA A RECURRING MOTIF IN CDR H3. JRNL REF NAT COMMUN V. 16 7067 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 40750588 JRNL DOI 10.1038/S41467-025-62174-2 REMARK 2 REMARK 2 RESOLUTION. 2.97 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, EPU, CRYOSPARC, PHENIX, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.970 REMARK 3 NUMBER OF PARTICLES : 104786 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9CYJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-AUG-24. REMARK 100 THE DEPOSITION ID IS D_1000285701. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : FNI9 IGG IN COMPLEX WITH REMARK 245 INFLUENZA VIRUS NEURAMINIDASE REMARK 245 FROM A/KANSAS/14/2017 (H3N2) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4500.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, H, L, B, A, D, E, F, G, I, REMARK 350 AND CHAINS: J, K, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET C 1 REMARK 465 ASP C 2 REMARK 465 ALA C 3 REMARK 465 MET C 4 REMARK 465 LYS C 5 REMARK 465 ARG C 6 REMARK 465 GLY C 7 REMARK 465 LEU C 8 REMARK 465 CYS C 9 REMARK 465 CYS C 10 REMARK 465 VAL C 11 REMARK 465 LEU C 12 REMARK 465 LEU C 13 REMARK 465 LEU C 14 REMARK 465 CYS C 15 REMARK 465 GLY C 16 REMARK 465 ALA C 17 REMARK 465 VAL C 18 REMARK 465 PHE C 19 REMARK 465 VAL C 20 REMARK 465 SER C 21 REMARK 465 PRO C 22 REMARK 465 HIS C 23 REMARK 465 HIS C 24 REMARK 465 HIS C 25 REMARK 465 HIS C 26 REMARK 465 HIS C 27 REMARK 465 HIS C 28 REMARK 465 GLY C 29 REMARK 465 SER C 30 REMARK 465 SER C 31 REMARK 465 SER C 32 REMARK 465 SER C 33 REMARK 465 ASP C 34 REMARK 465 TYR C 35 REMARK 465 SER C 36 REMARK 465 ASP C 37 REMARK 465 LEU C 38 REMARK 465 GLN C 39 REMARK 465 ARG C 40 REMARK 465 VAL C 41 REMARK 465 LYS C 42 REMARK 465 GLN C 43 REMARK 465 GLU C 44 REMARK 465 LEU C 45 REMARK 465 LEU C 46 REMARK 465 GLU C 47 REMARK 465 GLU C 48 REMARK 465 VAL C 49 REMARK 465 LYS C 50 REMARK 465 LYS C 51 REMARK 465 GLU C 52 REMARK 465 LEU C 53 REMARK 465 GLN C 54 REMARK 465 LYS C 55 REMARK 465 VAL C 56 REMARK 465 LYS C 57 REMARK 465 GLU C 58 REMARK 465 GLU C 59 REMARK 465 ILE C 60 REMARK 465 ILE C 61 REMARK 465 GLU C 62 REMARK 465 ALA C 63 REMARK 465 PHE C 64 REMARK 465 VAL C 65 REMARK 465 GLN C 66 REMARK 465 GLU C 67 REMARK 465 LEU C 68 REMARK 465 ARG C 69 REMARK 465 LYS C 70 REMARK 465 ARG C 71 REMARK 465 GLY C 72 REMARK 465 SER C 73 REMARK 465 GLU C 74 REMARK 465 ASN C 75 REMARK 465 LEU C 76 REMARK 465 TYR C 77 REMARK 465 PHE C 78 REMARK 465 GLN C 79 REMARK 465 SER C 80 REMARK 465 GLY C 81 REMARK 465 THR H 131 REMARK 465 LYS H 132 REMARK 465 GLY H 133 REMARK 465 PRO H 134 REMARK 465 SER H 135 REMARK 465 VAL H 136 REMARK 465 PHE H 137 REMARK 465 PRO H 138 REMARK 465 LEU H 139 REMARK 465 ALA H 140 REMARK 465 PRO H 141 REMARK 465 SER H 142 REMARK 465 SER H 143 REMARK 465 LYS H 144 REMARK 465 SER H 145 REMARK 465 THR H 146 REMARK 465 SER H 147 REMARK 465 GLY H 148 REMARK 465 GLY H 149 REMARK 465 THR H 150 REMARK 465 ALA H 151 REMARK 465 ALA H 152 REMARK 465 LEU H 153 REMARK 465 GLY H 154 REMARK 465 CYS H 155 REMARK 465 LEU H 156 REMARK 465 VAL H 157 REMARK 465 LYS H 158 REMARK 465 ASP H 159 REMARK 465 TYR H 160 REMARK 465 PHE H 161 REMARK 465 PRO H 162 REMARK 465 GLU H 163 REMARK 465 PRO H 164 REMARK 465 VAL H 165 REMARK 465 THR H 166 REMARK 465 VAL H 167 REMARK 465 SER H 168 REMARK 465 TRP H 169 REMARK 465 ASN H 170 REMARK 465 SER H 171 REMARK 465 GLY H 172 REMARK 465 ALA H 173 REMARK 465 LEU H 174 REMARK 465 THR H 175 REMARK 465 SER H 176 REMARK 465 GLY H 177 REMARK 465 VAL H 178 REMARK 465 HIS H 179 REMARK 465 THR H 180 REMARK 465 PHE H 181 REMARK 465 PRO H 182 REMARK 465 ALA H 183 REMARK 465 VAL H 184 REMARK 465 LEU H 185 REMARK 465 GLN H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 GLY H 189 REMARK 465 LEU H 190 REMARK 465 TYR H 191 REMARK 465 SER H 192 REMARK 465 LEU H 193 REMARK 465 SER H 194 REMARK 465 SER H 195 REMARK 465 VAL H 196 REMARK 465 VAL H 197 REMARK 465 THR H 198 REMARK 465 VAL H 199 REMARK 465 PRO H 200 REMARK 465 SER H 201 REMARK 465 SER H 202 REMARK 465 SER H 203 REMARK 465 LEU H 204 REMARK 465 GLY H 205 REMARK 465 THR H 206 REMARK 465 GLN H 207 REMARK 465 THR H 208 REMARK 465 TYR H 209 REMARK 465 ILE H 210 REMARK 465 CYS H 211 REMARK 465 ASN H 212 REMARK 465 VAL H 213 REMARK 465 ASN H 214 REMARK 465 HIS H 215 REMARK 465 LYS H 216 REMARK 465 PRO H 217 REMARK 465 SER H 218 REMARK 465 ASN H 219 REMARK 465 THR H 220 REMARK 465 LYS H 221 REMARK 465 VAL H 222 REMARK 465 ASP H 223 REMARK 465 LYS H 224 REMARK 465 LYS H 225 REMARK 465 VAL H 226 REMARK 465 GLU H 227 REMARK 465 PRO H 228 REMARK 465 LYS H 229 REMARK 465 SER H 230 REMARK 465 CYS H 231 REMARK 465 VAL L 111 REMARK 465 ALA L 112 REMARK 465 ALA L 113 REMARK 465 PRO L 114 REMARK 465 SER L 115 REMARK 465 VAL L 116 REMARK 465 PHE L 117 REMARK 465 ILE L 118 REMARK 465 PHE L 119 REMARK 465 PRO L 120 REMARK 465 PRO L 121 REMARK 465 SER L 122 REMARK 465 ASP L 123 REMARK 465 GLU L 124 REMARK 465 GLN L 125 REMARK 465 LEU L 126 REMARK 465 LYS L 127 REMARK 465 SER L 128 REMARK 465 GLY L 129 REMARK 465 THR L 130 REMARK 465 ALA L 131 REMARK 465 SER L 132 REMARK 465 VAL L 133 REMARK 465 VAL L 134 REMARK 465 CYS L 135 REMARK 465 LEU L 136 REMARK 465 LEU L 137 REMARK 465 ASN L 138 REMARK 465 ASN L 139 REMARK 465 PHE L 140 REMARK 465 TYR L 141 REMARK 465 PRO L 142 REMARK 465 ARG L 143 REMARK 465 GLU L 144 REMARK 465 ALA L 145 REMARK 465 LYS L 146 REMARK 465 VAL L 147 REMARK 465 GLN L 148 REMARK 465 TRP L 149 REMARK 465 LYS L 150 REMARK 465 VAL L 151 REMARK 465 ASP L 152 REMARK 465 ASN L 153 REMARK 465 ALA L 154 REMARK 465 LEU L 155 REMARK 465 GLN L 156 REMARK 465 SER L 157 REMARK 465 GLY L 158 REMARK 465 ASN L 159 REMARK 465 SER L 160 REMARK 465 GLN L 161 REMARK 465 GLU L 162 REMARK 465 SER L 163 REMARK 465 VAL L 164 REMARK 465 THR L 165 REMARK 465 GLU L 166 REMARK 465 GLN L 167 REMARK 465 ASP L 168 REMARK 465 SER L 169 REMARK 465 LYS L 170 REMARK 465 ASP L 171 REMARK 465 SER L 172 REMARK 465 THR L 173 REMARK 465 TYR L 174 REMARK 465 SER L 175 REMARK 465 LEU L 176 REMARK 465 SER L 177 REMARK 465 SER L 178 REMARK 465 THR L 179 REMARK 465 LEU L 180 REMARK 465 THR L 181 REMARK 465 LEU L 182 REMARK 465 SER L 183 REMARK 465 LYS L 184 REMARK 465 ALA L 185 REMARK 465 ASP L 186 REMARK 465 TYR L 187 REMARK 465 GLU L 188 REMARK 465 LYS L 189 REMARK 465 HIS L 190 REMARK 465 LYS L 191 REMARK 465 VAL L 192 REMARK 465 TYR L 193 REMARK 465 ALA L 194 REMARK 465 CYS L 195 REMARK 465 GLU L 196 REMARK 465 VAL L 197 REMARK 465 THR L 198 REMARK 465 HIS L 199 REMARK 465 GLN L 200 REMARK 465 GLY L 201 REMARK 465 LEU L 202 REMARK 465 SER L 203 REMARK 465 SER L 204 REMARK 465 PRO L 205 REMARK 465 VAL L 206 REMARK 465 THR L 207 REMARK 465 LYS L 208 REMARK 465 SER L 209 REMARK 465 PHE L 210 REMARK 465 ASN L 211 REMARK 465 ARG L 212 REMARK 465 GLY L 213 REMARK 465 GLU L 214 REMARK 465 CYS L 215 REMARK 465 MET B 1 REMARK 465 ASP B 2 REMARK 465 ALA B 3 REMARK 465 MET B 4 REMARK 465 LYS B 5 REMARK 465 ARG B 6 REMARK 465 GLY B 7 REMARK 465 LEU B 8 REMARK 465 CYS B 9 REMARK 465 CYS B 10 REMARK 465 VAL B 11 REMARK 465 LEU B 12 REMARK 465 LEU B 13 REMARK 465 LEU B 14 REMARK 465 CYS B 15 REMARK 465 GLY B 16 REMARK 465 ALA B 17 REMARK 465 VAL B 18 REMARK 465 PHE B 19 REMARK 465 VAL B 20 REMARK 465 SER B 21 REMARK 465 PRO B 22 REMARK 465 HIS B 23 REMARK 465 HIS B 24 REMARK 465 HIS B 25 REMARK 465 HIS B 26 REMARK 465 HIS B 27 REMARK 465 HIS B 28 REMARK 465 GLY B 29 REMARK 465 SER B 30 REMARK 465 SER B 31 REMARK 465 SER B 32 REMARK 465 SER B 33 REMARK 465 ASP B 34 REMARK 465 TYR B 35 REMARK 465 SER B 36 REMARK 465 ASP B 37 REMARK 465 LEU B 38 REMARK 465 GLN B 39 REMARK 465 ARG B 40 REMARK 465 VAL B 41 REMARK 465 LYS B 42 REMARK 465 GLN B 43 REMARK 465 GLU B 44 REMARK 465 LEU B 45 REMARK 465 LEU B 46 REMARK 465 GLU B 47 REMARK 465 GLU B 48 REMARK 465 VAL B 49 REMARK 465 LYS B 50 REMARK 465 LYS B 51 REMARK 465 GLU B 52 REMARK 465 LEU B 53 REMARK 465 GLN B 54 REMARK 465 LYS B 55 REMARK 465 VAL B 56 REMARK 465 LYS B 57 REMARK 465 GLU B 58 REMARK 465 GLU B 59 REMARK 465 ILE B 60 REMARK 465 ILE B 61 REMARK 465 GLU B 62 REMARK 465 ALA B 63 REMARK 465 PHE B 64 REMARK 465 VAL B 65 REMARK 465 GLN B 66 REMARK 465 GLU B 67 REMARK 465 LEU B 68 REMARK 465 ARG B 69 REMARK 465 LYS B 70 REMARK 465 ARG B 71 REMARK 465 GLY B 72 REMARK 465 SER B 73 REMARK 465 GLU B 74 REMARK 465 ASN B 75 REMARK 465 LEU B 76 REMARK 465 TYR B 77 REMARK 465 PHE B 78 REMARK 465 GLN B 79 REMARK 465 SER B 80 REMARK 465 GLY B 81 REMARK 465 MET A 1 REMARK 465 ASP A 2 REMARK 465 ALA A 3 REMARK 465 MET A 4 REMARK 465 LYS A 5 REMARK 465 ARG A 6 REMARK 465 GLY A 7 REMARK 465 LEU A 8 REMARK 465 CYS A 9 REMARK 465 CYS A 10 REMARK 465 VAL A 11 REMARK 465 LEU A 12 REMARK 465 LEU A 13 REMARK 465 LEU A 14 REMARK 465 CYS A 15 REMARK 465 GLY A 16 REMARK 465 ALA A 17 REMARK 465 VAL A 18 REMARK 465 PHE A 19 REMARK 465 VAL A 20 REMARK 465 SER A 21 REMARK 465 PRO A 22 REMARK 465 HIS A 23 REMARK 465 HIS A 24 REMARK 465 HIS A 25 REMARK 465 HIS A 26 REMARK 465 HIS A 27 REMARK 465 HIS A 28 REMARK 465 GLY A 29 REMARK 465 SER A 30 REMARK 465 SER A 31 REMARK 465 SER A 32 REMARK 465 SER A 33 REMARK 465 ASP A 34 REMARK 465 TYR A 35 REMARK 465 SER A 36 REMARK 465 ASP A 37 REMARK 465 LEU A 38 REMARK 465 GLN A 39 REMARK 465 ARG A 40 REMARK 465 VAL A 41 REMARK 465 LYS A 42 REMARK 465 GLN A 43 REMARK 465 GLU A 44 REMARK 465 LEU A 45 REMARK 465 LEU A 46 REMARK 465 GLU A 47 REMARK 465 GLU A 48 REMARK 465 VAL A 49 REMARK 465 LYS A 50 REMARK 465 LYS A 51 REMARK 465 GLU A 52 REMARK 465 LEU A 53 REMARK 465 GLN A 54 REMARK 465 LYS A 55 REMARK 465 VAL A 56 REMARK 465 LYS A 57 REMARK 465 GLU A 58 REMARK 465 GLU A 59 REMARK 465 ILE A 60 REMARK 465 ILE A 61 REMARK 465 GLU A 62 REMARK 465 ALA A 63 REMARK 465 PHE A 64 REMARK 465 VAL A 65 REMARK 465 GLN A 66 REMARK 465 GLU A 67 REMARK 465 LEU A 68 REMARK 465 ARG A 69 REMARK 465 LYS A 70 REMARK 465 ARG A 71 REMARK 465 GLY A 72 REMARK 465 SER A 73 REMARK 465 GLU A 74 REMARK 465 ASN A 75 REMARK 465 LEU A 76 REMARK 465 TYR A 77 REMARK 465 PHE A 78 REMARK 465 GLN A 79 REMARK 465 SER A 80 REMARK 465 GLY A 81 REMARK 465 MET D 1 REMARK 465 ASP D 2 REMARK 465 ALA D 3 REMARK 465 MET D 4 REMARK 465 LYS D 5 REMARK 465 ARG D 6 REMARK 465 GLY D 7 REMARK 465 LEU D 8 REMARK 465 CYS D 9 REMARK 465 CYS D 10 REMARK 465 VAL D 11 REMARK 465 LEU D 12 REMARK 465 LEU D 13 REMARK 465 LEU D 14 REMARK 465 CYS D 15 REMARK 465 GLY D 16 REMARK 465 ALA D 17 REMARK 465 VAL D 18 REMARK 465 PHE D 19 REMARK 465 VAL D 20 REMARK 465 SER D 21 REMARK 465 PRO D 22 REMARK 465 HIS D 23 REMARK 465 HIS D 24 REMARK 465 HIS D 25 REMARK 465 HIS D 26 REMARK 465 HIS D 27 REMARK 465 HIS D 28 REMARK 465 GLY D 29 REMARK 465 SER D 30 REMARK 465 SER D 31 REMARK 465 SER D 32 REMARK 465 SER D 33 REMARK 465 ASP D 34 REMARK 465 TYR D 35 REMARK 465 SER D 36 REMARK 465 ASP D 37 REMARK 465 LEU D 38 REMARK 465 GLN D 39 REMARK 465 ARG D 40 REMARK 465 VAL D 41 REMARK 465 LYS D 42 REMARK 465 GLN D 43 REMARK 465 GLU D 44 REMARK 465 LEU D 45 REMARK 465 LEU D 46 REMARK 465 GLU D 47 REMARK 465 GLU D 48 REMARK 465 VAL D 49 REMARK 465 LYS D 50 REMARK 465 LYS D 51 REMARK 465 GLU D 52 REMARK 465 LEU D 53 REMARK 465 GLN D 54 REMARK 465 LYS D 55 REMARK 465 VAL D 56 REMARK 465 LYS D 57 REMARK 465 GLU D 58 REMARK 465 GLU D 59 REMARK 465 ILE D 60 REMARK 465 ILE D 61 REMARK 465 GLU D 62 REMARK 465 ALA D 63 REMARK 465 PHE D 64 REMARK 465 VAL D 65 REMARK 465 GLN D 66 REMARK 465 GLU D 67 REMARK 465 LEU D 68 REMARK 465 ARG D 69 REMARK 465 LYS D 70 REMARK 465 ARG D 71 REMARK 465 GLY D 72 REMARK 465 SER D 73 REMARK 465 GLU D 74 REMARK 465 ASN D 75 REMARK 465 LEU D 76 REMARK 465 TYR D 77 REMARK 465 PHE D 78 REMARK 465 GLN D 79 REMARK 465 SER D 80 REMARK 465 GLY D 81 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG SER A 217 O SER A 219 2.11 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS C 124 CA - CB - SG ANGL. DEV. = 8.9 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LYS C 128 -169.83 -127.81 REMARK 500 PHE C 167 96.58 -69.66 REMARK 500 ASP C 221 -166.47 -126.88 REMARK 500 THR C 225 -168.23 -128.49 REMARK 500 CYS C 291 -169.09 -126.70 REMARK 500 ASP C 324 50.52 -150.02 REMARK 500 ALA C 353 149.34 -171.88 REMARK 500 ASP C 356 55.08 -93.47 REMARK 500 ILE H 54 -62.66 -90.51 REMARK 500 ALA L 51 -98.78 61.47 REMARK 500 TYR L 91 62.16 -104.11 REMARK 500 ASN L 93 -103.50 59.54 REMARK 500 TRP L 97 77.01 -101.36 REMARK 500 SER B 179 116.43 -160.69 REMARK 500 SER B 181 112.07 -162.78 REMARK 500 THR B 225 -167.96 -129.08 REMARK 500 LYS B 296 62.56 61.26 REMARK 500 SER B 315 -167.51 -162.96 REMARK 500 ARG B 371 57.89 -95.32 REMARK 500 SER B 404 -168.86 -128.84 REMARK 500 SER B 440 -169.94 -117.24 REMARK 500 SER A 179 119.53 -161.19 REMARK 500 SER A 181 115.25 -161.31 REMARK 500 ASP A 221 -166.67 -127.07 REMARK 500 ALA A 246 90.15 -68.35 REMARK 500 LEU A 338 -60.65 -91.25 REMARK 500 ALA A 353 139.10 -170.38 REMARK 500 ARG A 371 57.22 -93.48 REMARK 500 TRP D 295 -52.72 -120.38 REMARK 500 SER D 315 -168.59 -162.21 REMARK 500 ALA D 353 148.51 -172.31 REMARK 500 ASN D 358 -7.49 76.53 REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA C 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 GLY C 297 O REMARK 620 2 GLY C 346 O 134.2 REMARK 620 N 1 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA A 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP A 293 O REMARK 620 2 GLY A 345 O 111.9 REMARK 620 N 1 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-46046 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF FNI9 IGG IN COMPLEX WITH INFLUENZA VIRUS REMARK 900 NEURAMINIDASE FROM A/KANSAS/14/2017 (H3N2) DBREF1 9CYJ C 83 469 UNP A0A3G8EZM0_9INFA DBREF2 9CYJ C A0A3G8EZM0 83 469 DBREF 9CYJ H 1 231 PDB 9CYJ 9CYJ 1 231 DBREF 9CYJ L 1 215 PDB 9CYJ 9CYJ 1 215 DBREF1 9CYJ B 83 469 UNP A0A3G8EZM0_9INFA DBREF2 9CYJ B A0A3G8EZM0 83 469 DBREF1 9CYJ A 83 469 UNP A0A3G8EZM0_9INFA DBREF2 9CYJ A A0A3G8EZM0 83 469 DBREF1 9CYJ D 83 469 UNP A0A3G8EZM0_9INFA DBREF2 9CYJ D A0A3G8EZM0 83 469 SEQADV 9CYJ MET C 1 UNP A0A3G8EZM INITIATING METHIONINE SEQADV 9CYJ ASP C 2 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA C 3 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ MET C 4 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS C 5 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG C 6 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY C 7 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 8 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS C 9 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS C 10 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL C 11 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 12 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 13 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 14 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS C 15 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY C 16 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA C 17 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL C 18 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE C 19 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL C 20 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 21 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PRO C 22 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS C 23 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS C 24 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS C 25 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS C 26 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS C 27 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS C 28 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY C 29 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 30 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 31 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 32 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 33 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP C 34 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR C 35 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 36 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP C 37 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 38 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN C 39 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG C 40 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL C 41 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS C 42 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN C 43 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 44 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 45 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 46 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 47 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 48 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL C 49 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS C 50 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS C 51 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 52 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 53 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN C 54 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS C 55 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL C 56 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS C 57 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 58 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 59 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE C 60 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE C 61 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 62 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA C 63 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE C 64 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL C 65 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN C 66 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 67 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 68 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG C 69 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS C 70 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG C 71 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY C 72 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 73 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU C 74 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASN C 75 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU C 76 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR C 77 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE C 78 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN C 79 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 80 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY C 81 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER C 82 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ MET B 1 UNP A0A3G8EZM INITIATING METHIONINE SEQADV 9CYJ ASP B 2 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA B 3 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ MET B 4 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS B 5 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG B 6 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY B 7 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 8 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS B 9 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS B 10 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL B 11 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 12 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 13 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 14 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS B 15 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY B 16 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA B 17 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL B 18 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE B 19 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL B 20 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 21 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PRO B 22 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS B 23 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS B 24 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS B 25 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS B 26 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS B 27 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS B 28 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY B 29 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 30 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 31 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 32 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 33 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP B 34 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR B 35 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 36 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP B 37 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 38 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN B 39 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG B 40 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL B 41 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS B 42 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN B 43 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 44 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 45 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 46 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 47 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 48 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL B 49 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS B 50 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS B 51 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 52 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 53 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN B 54 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS B 55 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL B 56 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS B 57 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 58 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 59 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE B 60 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE B 61 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 62 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA B 63 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE B 64 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL B 65 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN B 66 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 67 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 68 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG B 69 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS B 70 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG B 71 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY B 72 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 73 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU B 74 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASN B 75 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU B 76 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR B 77 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE B 78 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN B 79 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 80 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY B 81 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER B 82 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ MET A 1 UNP A0A3G8EZM INITIATING METHIONINE SEQADV 9CYJ ASP A 2 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA A 3 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ MET A 4 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS A 5 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG A 6 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY A 7 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 8 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS A 9 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS A 10 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL A 11 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 12 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 13 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 14 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS A 15 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY A 16 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA A 17 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL A 18 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE A 19 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL A 20 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 21 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PRO A 22 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS A 23 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS A 24 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS A 25 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS A 26 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS A 27 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS A 28 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY A 29 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 30 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 31 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 32 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 33 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP A 34 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR A 35 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 36 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP A 37 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 38 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN A 39 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG A 40 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL A 41 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS A 42 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN A 43 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 44 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 45 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 46 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 47 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 48 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL A 49 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS A 50 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS A 51 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 52 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 53 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN A 54 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS A 55 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL A 56 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS A 57 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 58 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 59 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE A 60 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE A 61 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 62 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA A 63 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE A 64 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL A 65 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN A 66 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 67 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 68 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG A 69 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS A 70 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG A 71 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY A 72 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 73 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU A 74 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASN A 75 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU A 76 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR A 77 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE A 78 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN A 79 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 80 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY A 81 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER A 82 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ MET D 1 UNP A0A3G8EZM INITIATING METHIONINE SEQADV 9CYJ ASP D 2 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA D 3 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ MET D 4 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS D 5 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG D 6 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY D 7 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 8 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS D 9 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS D 10 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL D 11 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 12 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 13 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 14 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ CYS D 15 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY D 16 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA D 17 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL D 18 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE D 19 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL D 20 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 21 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PRO D 22 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS D 23 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS D 24 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS D 25 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS D 26 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS D 27 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ HIS D 28 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY D 29 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 30 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 31 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 32 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 33 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP D 34 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR D 35 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 36 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASP D 37 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 38 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN D 39 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG D 40 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL D 41 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS D 42 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN D 43 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 44 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 45 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 46 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 47 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 48 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL D 49 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS D 50 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS D 51 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 52 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 53 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN D 54 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS D 55 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL D 56 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS D 57 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 58 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 59 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE D 60 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ILE D 61 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 62 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ALA D 63 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE D 64 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ VAL D 65 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN D 66 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 67 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 68 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG D 69 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LYS D 70 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ARG D 71 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY D 72 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 73 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLU D 74 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ ASN D 75 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ LEU D 76 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ TYR D 77 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ PHE D 78 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLN D 79 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 80 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ GLY D 81 UNP A0A3G8EZM EXPRESSION TAG SEQADV 9CYJ SER D 82 UNP A0A3G8EZM EXPRESSION TAG SEQRES 1 C 469 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 C 469 LEU CYS GLY ALA VAL PHE VAL SER PRO HIS HIS HIS HIS SEQRES 3 C 469 HIS HIS GLY SER SER SER SER ASP TYR SER ASP LEU GLN SEQRES 4 C 469 ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU SEQRES 5 C 469 LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL SEQRES 6 C 469 GLN GLU LEU ARG LYS ARG GLY SER GLU ASN LEU TYR PHE SEQRES 7 C 469 GLN SER GLY SER GLU TYR ARG ASN TRP SER LYS PRO GLN SEQRES 8 C 469 CYS GLY ILE THR GLY PHE ALA PRO PHE SER LYS ASP ASN SEQRES 9 C 469 SER ILE ARG LEU SER ALA GLY GLY ASP ILE TRP VAL THR SEQRES 10 C 469 ARG GLU PRO TYR VAL SER CYS ASP PRO ASP LYS CYS TYR SEQRES 11 C 469 GLN PHE ALA LEU GLY GLN GLY THR THR ILE ASN ASN VAL SEQRES 12 C 469 HIS SER ASN ASN THR ALA ARG ASP ARG THR PRO HIS ARG SEQRES 13 C 469 THR LEU LEU MET ASN GLU LEU GLY VAL PRO PHE HIS LEU SEQRES 14 C 469 GLY THR LYS GLN VAL CYS ILE ALA TRP SER SER SER SER SEQRES 15 C 469 CYS HIS ASP GLY LYS ALA TRP LEU HIS VAL CYS ILE THR SEQRES 16 C 469 GLY ASP ASP LYS ASN ALA THR ALA SER PHE ILE TYR ASN SEQRES 17 C 469 GLY ARG LEU VAL ASP SER VAL VAL SER TRP SER LYS ASP SEQRES 18 C 469 ILE LEU ARG THR GLN GLU SER GLU CYS VAL CYS ILE ASN SEQRES 19 C 469 GLY THR CYS THR VAL VAL MET THR ASP GLY ASN ALA THR SEQRES 20 C 469 GLY LYS ALA ASP THR LYS ILE LEU PHE ILE GLU GLU GLY SEQRES 21 C 469 LYS ILE VAL HIS THR SER LYS LEU SER GLY SER ALA GLN SEQRES 22 C 469 HIS VAL GLU GLU CYS SER CYS TYR PRO ARG TYR PRO GLY SEQRES 23 C 469 VAL ARG CYS VAL CYS ARG ASP ASN TRP LYS GLY SER ASN SEQRES 24 C 469 ARG PRO ILE VAL ASP ILE ASN ILE LYS ASP HIS SER ILE SEQRES 25 C 469 VAL SER SER TYR VAL CYS SER GLY LEU VAL GLY ASP THR SEQRES 26 C 469 PRO ARG LYS THR ASP SER SER SER SER SER HIS CYS LEU SEQRES 27 C 469 ASN PRO ASN ASN GLU LYS GLY GLY HIS GLY VAL LYS GLY SEQRES 28 C 469 TRP ALA PHE ASP ASP GLY ASN ASP VAL TRP MET GLY ARG SEQRES 29 C 469 THR ILE ASN GLU THR SER ARG LEU GLY TYR GLU THR PHE SEQRES 30 C 469 LYS VAL VAL GLU GLY TRP SER ASN PRO LYS SER LYS LEU SEQRES 31 C 469 GLN ILE ASN ARG GLN VAL ILE VAL ASP ARG GLY ASP ARG SEQRES 32 C 469 SER GLY TYR SER GLY ILE PHE SER VAL GLU GLY LYS SER SEQRES 33 C 469 CYS ILE ASN ARG CYS PHE TYR VAL GLU LEU ILE ARG GLY SEQRES 34 C 469 ARG LYS GLU GLU THR GLU VAL LEU TRP THR SER ASN SER SEQRES 35 C 469 ILE VAL VAL PHE CYS GLY THR SER GLY THR TYR GLY THR SEQRES 36 C 469 GLY SER TRP PRO ASP GLY ALA ASP LEU ASN LEU MET HIS SEQRES 37 C 469 ILE SEQRES 1 H 231 GLN VAL HIS LEU VAL GLN SER GLY ALA GLU VAL LYS GLU SEQRES 2 H 231 PRO GLY SER SER VAL THR VAL SER CYS LYS ALA SER GLY SEQRES 3 H 231 GLY SER PHE ASN ASN GLN ALA ILE SER TRP VAL ARG GLN SEQRES 4 H 231 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE PHE SEQRES 5 H 231 PRO ILE SER GLY THR PRO THR SER ALA GLN ARG PHE GLN SEQRES 6 H 231 GLY ARG VAL THR PHE THR ALA ASP GLU SER THR THR THR SEQRES 7 H 231 VAL TYR MET ASP LEU SER SER LEU ARG SER ASP ASP THR SEQRES 8 H 231 ALA VAL TYR TYR CYS ALA ARG ALA GLY SER ASP TYR PHE SEQRES 9 H 231 ASN ARG ASP LEU GLY TRP GLU ASN TYR TYR PHE ALA SER SEQRES 10 H 231 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 H 231 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 H 231 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 H 231 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 H 231 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 H 231 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 H 231 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 H 231 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 H 231 VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 L 215 GLU ILE VAL MET THR GLN SER PRO ALA THR LEU SER LEU SEQRES 2 L 215 SER SER GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 L 215 ARG SER VAL SER SER ASN LEU ALA TRP TYR GLN GLN LYS SEQRES 4 L 215 PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR ASP ALA SER SEQRES 5 L 215 THR ARG ALA THR GLY PHE SER ALA ARG PHE ALA GLY SER SEQRES 6 L 215 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 215 GLN SER GLU ASP SER ALA ILE TYR TYR CYS GLN GLN TYR SEQRES 8 L 215 ASN ASN TRP PRO PRO TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 L 215 VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 B 469 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 B 469 LEU CYS GLY ALA VAL PHE VAL SER PRO HIS HIS HIS HIS SEQRES 3 B 469 HIS HIS GLY SER SER SER SER ASP TYR SER ASP LEU GLN SEQRES 4 B 469 ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU SEQRES 5 B 469 LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL SEQRES 6 B 469 GLN GLU LEU ARG LYS ARG GLY SER GLU ASN LEU TYR PHE SEQRES 7 B 469 GLN SER GLY SER GLU TYR ARG ASN TRP SER LYS PRO GLN SEQRES 8 B 469 CYS GLY ILE THR GLY PHE ALA PRO PHE SER LYS ASP ASN SEQRES 9 B 469 SER ILE ARG LEU SER ALA GLY GLY ASP ILE TRP VAL THR SEQRES 10 B 469 ARG GLU PRO TYR VAL SER CYS ASP PRO ASP LYS CYS TYR SEQRES 11 B 469 GLN PHE ALA LEU GLY GLN GLY THR THR ILE ASN ASN VAL SEQRES 12 B 469 HIS SER ASN ASN THR ALA ARG ASP ARG THR PRO HIS ARG SEQRES 13 B 469 THR LEU LEU MET ASN GLU LEU GLY VAL PRO PHE HIS LEU SEQRES 14 B 469 GLY THR LYS GLN VAL CYS ILE ALA TRP SER SER SER SER SEQRES 15 B 469 CYS HIS ASP GLY LYS ALA TRP LEU HIS VAL CYS ILE THR SEQRES 16 B 469 GLY ASP ASP LYS ASN ALA THR ALA SER PHE ILE TYR ASN SEQRES 17 B 469 GLY ARG LEU VAL ASP SER VAL VAL SER TRP SER LYS ASP SEQRES 18 B 469 ILE LEU ARG THR GLN GLU SER GLU CYS VAL CYS ILE ASN SEQRES 19 B 469 GLY THR CYS THR VAL VAL MET THR ASP GLY ASN ALA THR SEQRES 20 B 469 GLY LYS ALA ASP THR LYS ILE LEU PHE ILE GLU GLU GLY SEQRES 21 B 469 LYS ILE VAL HIS THR SER LYS LEU SER GLY SER ALA GLN SEQRES 22 B 469 HIS VAL GLU GLU CYS SER CYS TYR PRO ARG TYR PRO GLY SEQRES 23 B 469 VAL ARG CYS VAL CYS ARG ASP ASN TRP LYS GLY SER ASN SEQRES 24 B 469 ARG PRO ILE VAL ASP ILE ASN ILE LYS ASP HIS SER ILE SEQRES 25 B 469 VAL SER SER TYR VAL CYS SER GLY LEU VAL GLY ASP THR SEQRES 26 B 469 PRO ARG LYS THR ASP SER SER SER SER SER HIS CYS LEU SEQRES 27 B 469 ASN PRO ASN ASN GLU LYS GLY GLY HIS GLY VAL LYS GLY SEQRES 28 B 469 TRP ALA PHE ASP ASP GLY ASN ASP VAL TRP MET GLY ARG SEQRES 29 B 469 THR ILE ASN GLU THR SER ARG LEU GLY TYR GLU THR PHE SEQRES 30 B 469 LYS VAL VAL GLU GLY TRP SER ASN PRO LYS SER LYS LEU SEQRES 31 B 469 GLN ILE ASN ARG GLN VAL ILE VAL ASP ARG GLY ASP ARG SEQRES 32 B 469 SER GLY TYR SER GLY ILE PHE SER VAL GLU GLY LYS SER SEQRES 33 B 469 CYS ILE ASN ARG CYS PHE TYR VAL GLU LEU ILE ARG GLY SEQRES 34 B 469 ARG LYS GLU GLU THR GLU VAL LEU TRP THR SER ASN SER SEQRES 35 B 469 ILE VAL VAL PHE CYS GLY THR SER GLY THR TYR GLY THR SEQRES 36 B 469 GLY SER TRP PRO ASP GLY ALA ASP LEU ASN LEU MET HIS SEQRES 37 B 469 ILE SEQRES 1 A 469 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 A 469 LEU CYS GLY ALA VAL PHE VAL SER PRO HIS HIS HIS HIS SEQRES 3 A 469 HIS HIS GLY SER SER SER SER ASP TYR SER ASP LEU GLN SEQRES 4 A 469 ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU SEQRES 5 A 469 LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL SEQRES 6 A 469 GLN GLU LEU ARG LYS ARG GLY SER GLU ASN LEU TYR PHE SEQRES 7 A 469 GLN SER GLY SER GLU TYR ARG ASN TRP SER LYS PRO GLN SEQRES 8 A 469 CYS GLY ILE THR GLY PHE ALA PRO PHE SER LYS ASP ASN SEQRES 9 A 469 SER ILE ARG LEU SER ALA GLY GLY ASP ILE TRP VAL THR SEQRES 10 A 469 ARG GLU PRO TYR VAL SER CYS ASP PRO ASP LYS CYS TYR SEQRES 11 A 469 GLN PHE ALA LEU GLY GLN GLY THR THR ILE ASN ASN VAL SEQRES 12 A 469 HIS SER ASN ASN THR ALA ARG ASP ARG THR PRO HIS ARG SEQRES 13 A 469 THR LEU LEU MET ASN GLU LEU GLY VAL PRO PHE HIS LEU SEQRES 14 A 469 GLY THR LYS GLN VAL CYS ILE ALA TRP SER SER SER SER SEQRES 15 A 469 CYS HIS ASP GLY LYS ALA TRP LEU HIS VAL CYS ILE THR SEQRES 16 A 469 GLY ASP ASP LYS ASN ALA THR ALA SER PHE ILE TYR ASN SEQRES 17 A 469 GLY ARG LEU VAL ASP SER VAL VAL SER TRP SER LYS ASP SEQRES 18 A 469 ILE LEU ARG THR GLN GLU SER GLU CYS VAL CYS ILE ASN SEQRES 19 A 469 GLY THR CYS THR VAL VAL MET THR ASP GLY ASN ALA THR SEQRES 20 A 469 GLY LYS ALA ASP THR LYS ILE LEU PHE ILE GLU GLU GLY SEQRES 21 A 469 LYS ILE VAL HIS THR SER LYS LEU SER GLY SER ALA GLN SEQRES 22 A 469 HIS VAL GLU GLU CYS SER CYS TYR PRO ARG TYR PRO GLY SEQRES 23 A 469 VAL ARG CYS VAL CYS ARG ASP ASN TRP LYS GLY SER ASN SEQRES 24 A 469 ARG PRO ILE VAL ASP ILE ASN ILE LYS ASP HIS SER ILE SEQRES 25 A 469 VAL SER SER TYR VAL CYS SER GLY LEU VAL GLY ASP THR SEQRES 26 A 469 PRO ARG LYS THR ASP SER SER SER SER SER HIS CYS LEU SEQRES 27 A 469 ASN PRO ASN ASN GLU LYS GLY GLY HIS GLY VAL LYS GLY SEQRES 28 A 469 TRP ALA PHE ASP ASP GLY ASN ASP VAL TRP MET GLY ARG SEQRES 29 A 469 THR ILE ASN GLU THR SER ARG LEU GLY TYR GLU THR PHE SEQRES 30 A 469 LYS VAL VAL GLU GLY TRP SER ASN PRO LYS SER LYS LEU SEQRES 31 A 469 GLN ILE ASN ARG GLN VAL ILE VAL ASP ARG GLY ASP ARG SEQRES 32 A 469 SER GLY TYR SER GLY ILE PHE SER VAL GLU GLY LYS SER SEQRES 33 A 469 CYS ILE ASN ARG CYS PHE TYR VAL GLU LEU ILE ARG GLY SEQRES 34 A 469 ARG LYS GLU GLU THR GLU VAL LEU TRP THR SER ASN SER SEQRES 35 A 469 ILE VAL VAL PHE CYS GLY THR SER GLY THR TYR GLY THR SEQRES 36 A 469 GLY SER TRP PRO ASP GLY ALA ASP LEU ASN LEU MET HIS SEQRES 37 A 469 ILE SEQRES 1 D 469 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 D 469 LEU CYS GLY ALA VAL PHE VAL SER PRO HIS HIS HIS HIS SEQRES 3 D 469 HIS HIS GLY SER SER SER SER ASP TYR SER ASP LEU GLN SEQRES 4 D 469 ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU SEQRES 5 D 469 LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL SEQRES 6 D 469 GLN GLU LEU ARG LYS ARG GLY SER GLU ASN LEU TYR PHE SEQRES 7 D 469 GLN SER GLY SER GLU TYR ARG ASN TRP SER LYS PRO GLN SEQRES 8 D 469 CYS GLY ILE THR GLY PHE ALA PRO PHE SER LYS ASP ASN SEQRES 9 D 469 SER ILE ARG LEU SER ALA GLY GLY ASP ILE TRP VAL THR SEQRES 10 D 469 ARG GLU PRO TYR VAL SER CYS ASP PRO ASP LYS CYS TYR SEQRES 11 D 469 GLN PHE ALA LEU GLY GLN GLY THR THR ILE ASN ASN VAL SEQRES 12 D 469 HIS SER ASN ASN THR ALA ARG ASP ARG THR PRO HIS ARG SEQRES 13 D 469 THR LEU LEU MET ASN GLU LEU GLY VAL PRO PHE HIS LEU SEQRES 14 D 469 GLY THR LYS GLN VAL CYS ILE ALA TRP SER SER SER SER SEQRES 15 D 469 CYS HIS ASP GLY LYS ALA TRP LEU HIS VAL CYS ILE THR SEQRES 16 D 469 GLY ASP ASP LYS ASN ALA THR ALA SER PHE ILE TYR ASN SEQRES 17 D 469 GLY ARG LEU VAL ASP SER VAL VAL SER TRP SER LYS ASP SEQRES 18 D 469 ILE LEU ARG THR GLN GLU SER GLU CYS VAL CYS ILE ASN SEQRES 19 D 469 GLY THR CYS THR VAL VAL MET THR ASP GLY ASN ALA THR SEQRES 20 D 469 GLY LYS ALA ASP THR LYS ILE LEU PHE ILE GLU GLU GLY SEQRES 21 D 469 LYS ILE VAL HIS THR SER LYS LEU SER GLY SER ALA GLN SEQRES 22 D 469 HIS VAL GLU GLU CYS SER CYS TYR PRO ARG TYR PRO GLY SEQRES 23 D 469 VAL ARG CYS VAL CYS ARG ASP ASN TRP LYS GLY SER ASN SEQRES 24 D 469 ARG PRO ILE VAL ASP ILE ASN ILE LYS ASP HIS SER ILE SEQRES 25 D 469 VAL SER SER TYR VAL CYS SER GLY LEU VAL GLY ASP THR SEQRES 26 D 469 PRO ARG LYS THR ASP SER SER SER SER SER HIS CYS LEU SEQRES 27 D 469 ASN PRO ASN ASN GLU LYS GLY GLY HIS GLY VAL LYS GLY SEQRES 28 D 469 TRP ALA PHE ASP ASP GLY ASN ASP VAL TRP MET GLY ARG SEQRES 29 D 469 THR ILE ASN GLU THR SER ARG LEU GLY TYR GLU THR PHE SEQRES 30 D 469 LYS VAL VAL GLU GLY TRP SER ASN PRO LYS SER LYS LEU SEQRES 31 D 469 GLN ILE ASN ARG GLN VAL ILE VAL ASP ARG GLY ASP ARG SEQRES 32 D 469 SER GLY TYR SER GLY ILE PHE SER VAL GLU GLY LYS SER SEQRES 33 D 469 CYS ILE ASN ARG CYS PHE TYR VAL GLU LEU ILE ARG GLY SEQRES 34 D 469 ARG LYS GLU GLU THR GLU VAL LEU TRP THR SER ASN SER SEQRES 35 D 469 ILE VAL VAL PHE CYS GLY THR SER GLY THR TYR GLY THR SEQRES 36 D 469 GLY SER TRP PRO ASP GLY ALA ASP LEU ASN LEU MET HIS SEQRES 37 D 469 ILE HET NAG E 1 14 HET FUC E 2 10 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET BMA G 3 11 HET MAN G 4 11 HET MAN G 5 11 HET MAN G 6 11 HET MAN G 7 11 HET MAN G 8 11 HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET FUC J 2 10 HET NAG K 1 14 HET NAG K 2 14 HET NAG M 1 14 HET NAG M 2 14 HET BMA M 3 11 HET MAN M 4 11 HET MAN M 5 11 HET MAN M 6 11 HET MAN M 7 11 HET MAN M 8 11 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET MAN P 4 11 HET MAN P 5 11 HET MAN P 6 11 HET MAN P 7 11 HET MAN P 8 11 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET FUC R 3 10 HET NAG S 1 14 HET FUC S 2 10 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET MAN U 6 11 HET MAN U 7 11 HET MAN U 8 11 HET NAG V 1 14 HET NAG V 2 14 HET CA C 501 1 HET NAG C 502 14 HET NAG C 503 14 HET CA B 501 1 HET NAG B 502 14 HET NAG B 503 14 HET CA A 501 1 HET NAG A 502 14 HET NAG A 503 14 HET CA D 501 1 HET NAG D 502 14 HET NAG D 503 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM FUC ALPHA-L-FUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETNAM CA CALCIUM ION HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN FUC ALPHA-L-FUCOSE; 6-DEOXY-ALPHA-L-GALACTOPYRANOSE; L- HETSYN 2 FUC FUCOSE; FUCOSE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 7 NAG 37(C8 H15 N O6) FORMUL 7 FUC 4(C6 H12 O5) FORMUL 9 BMA 4(C6 H12 O6) FORMUL 9 MAN 20(C6 H12 O6) FORMUL 23 CA 4(CA 2+) HELIX 1 AA1 ASN C 104 ALA C 110 1 7 HELIX 2 AA2 ASN C 142 ASN C 146 5 5 HELIX 3 AA3 ARG H 87 THR H 91 5 5 HELIX 4 AA4 ASN B 104 ALA B 110 1 7 HELIX 5 AA5 ASN B 142 ASN B 146 5 5 HELIX 6 AA6 ASP B 463 HIS B 468 1 6 HELIX 7 AA7 ASN A 104 ALA A 110 1 7 HELIX 8 AA8 ASN A 142 ASN A 146 5 5 HELIX 9 AA9 ASN D 104 GLY D 112 1 9 HELIX 10 AB1 ASN D 142 ASN D 146 5 5 SHEET 1 AA1 4 PHE C 97 LYS C 102 0 SHEET 2 AA1 4 THR C 439 GLY C 448 -1 O CYS C 447 N ALA C 98 SHEET 3 AA1 4 ILE C 418 GLY C 429 -1 N PHE C 422 O PHE C 446 SHEET 4 AA1 4 SER C 407 GLU C 413 -1 N PHE C 410 O CYS C 421 SHEET 1 AA2 4 TRP C 115 TYR C 121 0 SHEET 2 AA2 4 TYR C 130 THR C 139 -1 O PHE C 132 N TYR C 121 SHEET 3 AA2 4 THR C 157 GLU C 162 -1 O LEU C 159 N ALA C 133 SHEET 4 AA2 4 LYS C 172 ILE C 176 -1 O LYS C 172 N MET C 160 SHEET 1 AA3 4 SER C 179 HIS C 184 0 SHEET 2 AA3 4 TRP C 189 GLY C 196 -1 O LEU C 190 N CYS C 183 SHEET 3 AA3 4 ALA C 201 TYR C 207 -1 O SER C 204 N CYS C 193 SHEET 4 AA3 4 ARG C 210 VAL C 216 -1 O VAL C 215 N ALA C 203 SHEET 1 AA4 4 VAL C 231 ILE C 233 0 SHEET 2 AA4 4 THR C 236 GLY C 244 -1 O THR C 238 N VAL C 231 SHEET 3 AA4 4 ALA C 250 GLU C 258 -1 O ILE C 257 N CYS C 237 SHEET 4 AA4 4 LYS C 261 LYS C 267 -1 O HIS C 264 N PHE C 256 SHEET 1 AA5 4 GLU C 276 TYR C 281 0 SHEET 2 AA5 4 ARG C 288 ARG C 292 -1 O ARG C 292 N GLU C 276 SHEET 3 AA5 4 PRO C 301 ASN C 306 -1 O VAL C 303 N CYS C 289 SHEET 4 AA5 4 SER C 311 TYR C 316 -1 O VAL C 313 N ASP C 304 SHEET 1 AA6 4 TRP C 352 ASP C 356 0 SHEET 2 AA6 4 ASP C 359 ARG C 364 -1 O ASP C 359 N ASP C 356 SHEET 3 AA6 4 LEU C 372 VAL C 379 -1 O GLU C 375 N ARG C 364 SHEET 4 AA6 4 GLN C 391 ARG C 403 -1 O ILE C 392 N LYS C 378 SHEET 1 AA7 2 LEU H 4 GLN H 6 0 SHEET 2 AA7 2 CYS H 22 ALA H 24 -1 O LYS H 23 N VAL H 5 SHEET 1 AA8 6 GLU H 10 LYS H 12 0 SHEET 2 AA8 6 THR H 122 VAL H 126 1 O THR H 125 N GLU H 10 SHEET 3 AA8 6 ALA H 92 ALA H 99 -1 N TYR H 94 O THR H 122 SHEET 4 AA8 6 ILE H 34 GLN H 39 -1 N VAL H 37 O TYR H 95 SHEET 5 AA8 6 LEU H 45 ILE H 51 -1 O GLU H 46 N ARG H 38 SHEET 6 AA8 6 THR H 59 SER H 60 -1 O THR H 59 N GLY H 50 SHEET 1 AA9 4 GLU H 10 LYS H 12 0 SHEET 2 AA9 4 THR H 122 VAL H 126 1 O THR H 125 N GLU H 10 SHEET 3 AA9 4 ALA H 92 ALA H 99 -1 N TYR H 94 O THR H 122 SHEET 4 AA9 4 PHE H 115 TRP H 118 -1 O SER H 117 N ARG H 98 SHEET 1 AB1 3 VAL H 18 THR H 19 0 SHEET 2 AB1 3 THR H 78 LEU H 83 -1 O LEU H 83 N VAL H 18 SHEET 3 AB1 3 VAL H 68 ASP H 73 -1 N ASP H 73 O THR H 78 SHEET 1 AB2 5 THR L 10 SER L 14 0 SHEET 2 AB2 5 THR L 103 LYS L 108 1 O LYS L 108 N LEU L 13 SHEET 3 AB2 5 ILE L 85 GLN L 90 -1 N TYR L 86 O THR L 103 SHEET 4 AB2 5 LEU L 33 GLN L 38 -1 N ALA L 34 O GLN L 89 SHEET 5 AB2 5 LEU L 46 ILE L 48 -1 O LEU L 47 N TRP L 35 SHEET 1 AB3 3 ALA L 19 ARG L 24 0 SHEET 2 AB3 3 GLU L 70 ILE L 75 -1 O LEU L 73 N LEU L 21 SHEET 3 AB3 3 PHE L 62 SER L 67 -1 N SER L 65 O THR L 72 SHEET 1 AB4 4 GLY B 96 LYS B 102 0 SHEET 2 AB4 4 THR B 439 THR B 449 -1 O THR B 449 N GLY B 96 SHEET 3 AB4 4 ILE B 418 GLY B 429 -1 N PHE B 422 O PHE B 446 SHEET 4 AB4 4 SER B 407 GLU B 413 -1 N VAL B 412 O ASN B 419 SHEET 1 AB5 4 TYR B 121 CYS B 124 0 SHEET 2 AB5 4 CYS B 129 GLY B 135 -1 O PHE B 132 N TYR B 121 SHEET 3 AB5 4 THR B 157 GLU B 162 -1 O LEU B 159 N ALA B 133 SHEET 4 AB5 4 LYS B 172 ILE B 176 -1 O CYS B 175 N LEU B 158 SHEET 1 AB6 4 SER B 179 HIS B 184 0 SHEET 2 AB6 4 TRP B 189 ASP B 197 -1 O LEU B 190 N CYS B 183 SHEET 3 AB6 4 ASN B 200 TYR B 207 -1 O SER B 204 N CYS B 193 SHEET 4 AB6 4 ARG B 210 VAL B 216 -1 O VAL B 215 N ALA B 203 SHEET 1 AB7 4 VAL B 231 ILE B 233 0 SHEET 2 AB7 4 THR B 236 GLY B 244 -1 O THR B 238 N VAL B 231 SHEET 3 AB7 4 ALA B 250 GLU B 258 -1 O ILE B 257 N CYS B 237 SHEET 4 AB7 4 LYS B 261 LYS B 267 -1 O SER B 266 N ILE B 254 SHEET 1 AB8 4 SER B 279 TYR B 281 0 SHEET 2 AB8 4 ARG B 288 VAL B 290 -1 O ARG B 288 N TYR B 281 SHEET 3 AB8 4 PRO B 301 ASN B 306 -1 O VAL B 303 N CYS B 289 SHEET 4 AB8 4 SER B 311 TYR B 316 -1 O SER B 315 N ILE B 302 SHEET 1 AB9 4 TRP B 352 ASP B 355 0 SHEET 2 AB9 4 VAL B 360 ARG B 364 -1 O TRP B 361 N PHE B 354 SHEET 3 AB9 4 LEU B 372 VAL B 379 -1 O VAL B 379 N VAL B 360 SHEET 4 AB9 4 GLN B 391 ARG B 403 -1 O ASP B 402 N GLY B 373 SHEET 1 AC1 4 PHE A 97 SER A 101 0 SHEET 2 AC1 4 THR A 439 GLY A 448 -1 O VAL A 445 N SER A 101 SHEET 3 AC1 4 ILE A 418 GLY A 429 -1 N LEU A 426 O SER A 442 SHEET 4 AC1 4 SER A 407 GLU A 413 -1 N PHE A 410 O CYS A 421 SHEET 1 AC2 4 TYR A 121 CYS A 124 0 SHEET 2 AC2 4 CYS A 129 GLY A 135 -1 O PHE A 132 N TYR A 121 SHEET 3 AC2 4 THR A 157 GLU A 162 -1 O LEU A 159 N ALA A 133 SHEET 4 AC2 4 LYS A 172 ILE A 176 -1 O CYS A 175 N LEU A 158 SHEET 1 AC3 4 SER A 179 HIS A 184 0 SHEET 2 AC3 4 TRP A 189 GLY A 196 -1 O LEU A 190 N CYS A 183 SHEET 3 AC3 4 ALA A 201 TYR A 207 -1 O SER A 204 N CYS A 193 SHEET 4 AC3 4 ARG A 210 VAL A 216 -1 O ASP A 213 N PHE A 205 SHEET 1 AC4 3 LEU A 223 ARG A 224 0 SHEET 2 AC4 3 THR A 236 ASP A 243 -1 O THR A 242 N ARG A 224 SHEET 3 AC4 3 VAL A 231 ILE A 233 -1 N VAL A 231 O THR A 238 SHEET 1 AC5 4 LEU A 223 ARG A 224 0 SHEET 2 AC5 4 THR A 236 ASP A 243 -1 O THR A 242 N ARG A 224 SHEET 3 AC5 4 LYS A 253 GLU A 258 -1 O ILE A 257 N CYS A 237 SHEET 4 AC5 4 LYS A 261 LYS A 267 -1 O SER A 266 N ILE A 254 SHEET 1 AC6 4 GLU A 276 TYR A 281 0 SHEET 2 AC6 4 VAL A 287 ARG A 292 -1 O ARG A 292 N GLU A 276 SHEET 3 AC6 4 PRO A 301 ILE A 305 -1 O ILE A 305 N VAL A 287 SHEET 4 AC6 4 VAL A 313 TYR A 316 -1 O VAL A 313 N ASP A 304 SHEET 1 AC7 4 TRP A 352 ASP A 355 0 SHEET 2 AC7 4 ASP A 359 ARG A 364 -1 O TRP A 361 N PHE A 354 SHEET 3 AC7 4 LEU A 372 VAL A 380 -1 O GLU A 375 N ARG A 364 SHEET 4 AC7 4 GLN A 391 ARG A 403 -1 O ASP A 402 N GLY A 373 SHEET 1 AC8 4 PHE D 97 LYS D 102 0 SHEET 2 AC8 4 THR D 439 GLY D 448 -1 O VAL D 445 N SER D 101 SHEET 3 AC8 4 ILE D 418 GLY D 429 -1 N PHE D 422 O PHE D 446 SHEET 4 AC8 4 SER D 407 GLU D 413 -1 N VAL D 412 O ASN D 419 SHEET 1 AC9 4 TRP D 115 ASP D 125 0 SHEET 2 AC9 4 LYS D 128 THR D 139 -1 O PHE D 132 N TYR D 121 SHEET 3 AC9 4 THR D 157 GLU D 162 -1 O LEU D 159 N ALA D 133 SHEET 4 AC9 4 LYS D 172 ILE D 176 -1 O LYS D 172 N MET D 160 SHEET 1 AD1 4 SER D 179 HIS D 184 0 SHEET 2 AD1 4 TRP D 189 GLY D 196 -1 O VAL D 192 N SER D 181 SHEET 3 AD1 4 ALA D 201 TYR D 207 -1 O SER D 204 N CYS D 193 SHEET 4 AD1 4 LEU D 211 VAL D 216 -1 O VAL D 215 N ALA D 203 SHEET 1 AD2 4 VAL D 231 ILE D 233 0 SHEET 2 AD2 4 THR D 236 GLY D 244 -1 O THR D 238 N VAL D 231 SHEET 3 AD2 4 ALA D 250 GLU D 258 -1 O ILE D 257 N CYS D 237 SHEET 4 AD2 4 LYS D 261 LYS D 267 -1 O SER D 266 N ILE D 254 SHEET 1 AD3 4 GLU D 276 TYR D 281 0 SHEET 2 AD3 4 ARG D 288 ARG D 292 -1 O ARG D 292 N GLU D 276 SHEET 3 AD3 4 PRO D 301 ASN D 306 -1 O PRO D 301 N CYS D 291 SHEET 4 AD3 4 SER D 311 TYR D 316 -1 O SER D 315 N ILE D 302 SHEET 1 AD4 4 ALA D 353 ASP D 355 0 SHEET 2 AD4 4 VAL D 360 ARG D 364 -1 O TRP D 361 N PHE D 354 SHEET 3 AD4 4 LEU D 372 VAL D 379 -1 O VAL D 379 N VAL D 360 SHEET 4 AD4 4 GLN D 391 ARG D 403 -1 O ASP D 402 N GLY D 373 SSBOND 1 CYS C 92 CYS C 417 1555 1555 2.03 SSBOND 2 CYS C 124 CYS C 129 1555 1555 2.04 SSBOND 3 CYS C 175 CYS C 193 1555 1555 2.02 SSBOND 4 CYS C 183 CYS C 230 1555 1555 2.03 SSBOND 5 CYS C 232 CYS C 237 1555 1555 2.03 SSBOND 6 CYS C 278 CYS C 291 1555 1555 2.03 SSBOND 7 CYS C 280 CYS C 289 1555 1555 2.03 SSBOND 8 CYS C 318 CYS C 337 1555 1555 2.03 SSBOND 9 CYS C 421 CYS C 447 1555 1555 2.03 SSBOND 10 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 11 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 12 CYS B 92 CYS B 417 1555 1555 2.03 SSBOND 13 CYS B 124 CYS B 129 1555 1555 2.03 SSBOND 14 CYS B 175 CYS B 193 1555 1555 2.03 SSBOND 15 CYS B 183 CYS B 230 1555 1555 2.03 SSBOND 16 CYS B 232 CYS B 237 1555 1555 2.03 SSBOND 17 CYS B 278 CYS B 291 1555 1555 2.03 SSBOND 18 CYS B 280 CYS B 289 1555 1555 2.03 SSBOND 19 CYS B 318 CYS B 337 1555 1555 2.03 SSBOND 20 CYS B 421 CYS B 447 1555 1555 2.03 SSBOND 21 CYS A 92 CYS A 417 1555 1555 2.03 SSBOND 22 CYS A 124 CYS A 129 1555 1555 2.03 SSBOND 23 CYS A 175 CYS A 193 1555 1555 2.03 SSBOND 24 CYS A 183 CYS A 230 1555 1555 2.03 SSBOND 25 CYS A 232 CYS A 237 1555 1555 2.04 SSBOND 26 CYS A 278 CYS A 291 1555 1555 2.03 SSBOND 27 CYS A 280 CYS A 289 1555 1555 2.03 SSBOND 28 CYS A 318 CYS A 337 1555 1555 2.04 SSBOND 29 CYS A 421 CYS A 447 1555 1555 2.03 SSBOND 30 CYS D 92 CYS D 417 1555 1555 2.03 SSBOND 31 CYS D 124 CYS D 129 1555 1555 2.03 SSBOND 32 CYS D 175 CYS D 193 1555 1555 2.02 SSBOND 33 CYS D 183 CYS D 230 1555 1555 2.03 SSBOND 34 CYS D 232 CYS D 237 1555 1555 2.03 SSBOND 35 CYS D 278 CYS D 291 1555 1555 2.03 SSBOND 36 CYS D 280 CYS D 289 1555 1555 2.03 SSBOND 37 CYS D 318 CYS D 337 1555 1555 2.03 SSBOND 38 CYS D 421 CYS D 447 1555 1555 2.03 LINK ND2 ASN C 86 C1 NAG C 503 1555 1555 1.44 LINK ND2 ASN C 146 C1 NAG F 1 1555 1555 1.45 LINK ND2 ASN C 200 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN C 234 C1 NAG C 502 1555 1555 1.44 LINK ND2 ASN C 245 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN C 367 C1 NAG I 1 1555 1555 1.44 LINK ND2 ASN B 86 C1 NAG B 503 1555 1555 1.44 LINK ND2 ASN B 146 C1 NAG K 1 1555 1555 1.45 LINK ND2 ASN B 200 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN B 234 C1 NAG B 502 1555 1555 1.44 LINK ND2 ASN B 245 C1 NAG J 1 1555 1555 1.44 LINK ND2 ASN B 367 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN A 86 C1 NAG A 503 1555 1555 1.44 LINK ND2 ASN A 146 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN A 200 C1 NAG P 1 1555 1555 1.43 LINK ND2 ASN A 234 C1 NAG A 502 1555 1555 1.44 LINK ND2 ASN A 245 C1 NAG R 1 1555 1555 1.45 LINK ND2 ASN A 367 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN D 86 C1 NAG D 503 1555 1555 1.44 LINK ND2 ASN D 146 C1 NAG T 1 1555 1555 1.45 LINK ND2 ASN D 200 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN D 234 C1 NAG D 502 1555 1555 1.44 LINK ND2 ASN D 245 C1 NAG S 1 1555 1555 1.45 LINK ND2 ASN D 367 C1 NAG V 1 1555 1555 1.44 LINK O6 NAG E 1 C1 FUC E 2 1555 1555 1.45 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.45 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG G 2 C1 BMA G 3 1555 1555 1.44 LINK O3 BMA G 3 C1 MAN G 4 1555 1555 1.44 LINK O6 BMA G 3 C1 MAN G 6 1555 1555 1.44 LINK O2 MAN G 4 C1 MAN G 5 1555 1555 1.44 LINK O3 MAN G 6 C1 MAN G 7 1555 1555 1.44 LINK O6 MAN G 6 C1 MAN G 8 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.44 LINK O6 NAG J 1 C1 FUC J 2 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.45 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.44 LINK O3 BMA M 3 C1 MAN M 4 1555 1555 1.44 LINK O6 BMA M 3 C1 MAN M 6 1555 1555 1.44 LINK O2 MAN M 4 C1 MAN M 5 1555 1555 1.44 LINK O3 MAN M 6 C1 MAN M 7 1555 1555 1.44 LINK O6 MAN M 6 C1 MAN M 8 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.43 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.44 LINK O3 BMA P 3 C1 MAN P 4 1555 1555 1.44 LINK O6 BMA P 3 C1 MAN P 6 1555 1555 1.44 LINK O2 MAN P 4 C1 MAN P 5 1555 1555 1.44 LINK O3 MAN P 6 C1 MAN P 7 1555 1555 1.44 LINK O6 MAN P 6 C1 MAN P 8 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O6 NAG R 1 C1 FUC R 3 1555 1555 1.44 LINK O6 NAG S 1 C1 FUC S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.44 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.44 LINK O6 BMA U 3 C1 MAN U 6 1555 1555 1.44 LINK O2 MAN U 4 C1 MAN U 5 1555 1555 1.44 LINK O3 MAN U 6 C1 MAN U 7 1555 1555 1.44 LINK O6 MAN U 6 C1 MAN U 8 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O GLY C 297 CA CA C 501 1555 1555 2.41 LINK O GLY C 346 CA CA C 501 1555 1555 3.16 LINK O GLY B 297 CA CA B 501 1555 1555 3.10 LINK O ASP A 293 CA CA A 501 1555 1555 2.85 LINK O GLY A 345 CA CA A 501 1555 1555 2.63 CISPEP 1 THR C 325 PRO C 326 0 7.64 CISPEP 2 PRO L 95 PRO L 96 0 -3.72 CISPEP 3 THR B 325 PRO B 326 0 1.35 CISPEP 4 THR A 325 PRO A 326 0 4.88 CISPEP 5 THR D 325 PRO D 326 0 -3.53 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000