HEADER VIRAL PROTEIN/IMMUNE SYSTEM 20-AUG-24 9D90 TITLE CRYO-EM STRUCTURE OF PARTIALLY OPEN HIV-1 BG505 SOSIP.664 ENV BOUND TO TITLE 2 3-SCD4, 3-17B FAB AND 3-VRC34.01 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: SURFACE PROTEIN GP120; COMPND 3 CHAIN: A, B, C; COMPND 4 ENGINEERED: YES; COMPND 5 MUTATION: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: TRANSMEMBRANE PROTEIN GP41; COMPND 8 CHAIN: D, E, F; COMPND 9 ENGINEERED: YES; COMPND 10 MUTATION: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: VRC34.01 HEAVY CHAIN; COMPND 13 CHAIN: G, I, K; COMPND 14 ENGINEERED: YES; COMPND 15 MOL_ID: 4; COMPND 16 MOLECULE: VRC34.01 LIGHT CHAIN; COMPND 17 CHAIN: H, J, L; COMPND 18 ENGINEERED: YES; COMPND 19 MOL_ID: 5; COMPND 20 MOLECULE: T-CELL SURFACE GLYCOPROTEIN CD4; COMPND 21 CHAIN: M, N, O; COMPND 22 SYNONYM: T-CELL SURFACE ANTIGEN T4/LEU-3; COMPND 23 ENGINEERED: YES; COMPND 24 MOL_ID: 6; COMPND 25 MOLECULE: 17B FAB LIGHT CHAIN; COMPND 26 CHAIN: P, R, T; COMPND 27 ENGINEERED: YES; COMPND 28 MOL_ID: 7; COMPND 29 MOLECULE: 17B FAB HEAVY CHAIN; COMPND 30 CHAIN: Q, S, U; COMPND 31 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 GENE: ENV; SOURCE 5 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 9 ORGANISM_TAXID: 11676; SOURCE 10 GENE: ENV; SOURCE 11 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_TAXID: 9606; SOURCE 16 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 18 MOL_ID: 4; SOURCE 19 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 20 ORGANISM_TAXID: 9606; SOURCE 21 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 23 MOL_ID: 5; SOURCE 24 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 25 ORGANISM_COMMON: HUMAN; SOURCE 26 ORGANISM_TAXID: 9606; SOURCE 27 GENE: CD4; SOURCE 28 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 29 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 30 MOL_ID: 6; SOURCE 31 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 32 ORGANISM_TAXID: 9606; SOURCE 33 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 34 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 35 MOL_ID: 7; SOURCE 36 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 37 ORGANISM_TAXID: 9606; SOURCE 38 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 39 EXPRESSION_SYSTEM_TAXID: 40674 KEYWDS RECOMBINANTLY PURIFIED HIV-1 ENV, SCD4, 17B FAB AND VRC34.01 FAB, KEYWDS 2 VIRAL ENV, VACCINE, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM KEYWDS 3 COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR B.THAKUR,P.ACHARYA REVDAT 1 30-APR-25 9D90 0 JRNL AUTH B.THAKUR,P.ACHARYA JRNL TITL CRYO-EM STRUCTURE OF PARTIALLY OPEN HIV-1 BG505 SOSIP.664 JRNL TITL 2 ENV BOUND TO 3-SCD4, 3-17B FAB AND 3-VRC34.01 FAB JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.91 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, LATITUDE, CRYOSPARC, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.910 REMARK 3 NUMBER OF PARTICLES : 102849 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9D90 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 29-AUG-24. REMARK 100 THE DEPOSITION ID IS D_1000287557. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : A COMPLEX OF ECTODOMAIN OF HIV REMARK 245 -1 BG505 SOSIP.664 ENV WITH REMARK 245 SCD4, 17B FAB AND VRC34.01 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.30 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5870.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 21-MERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, a, f REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 LEU A 129 REMARK 465 GLN A 130 REMARK 465 CYS A 131 REMARK 465 THR A 132 REMARK 465 ASN A 133 REMARK 465 VAL A 134 REMARK 465 THR A 135 REMARK 465 ASN A 136 REMARK 465 ASN A 137 REMARK 465 ILE A 138 REMARK 465 THR A 139 REMARK 465 ASP A 140 REMARK 465 ASP A 141 REMARK 465 MET A 142 REMARK 465 ARG A 143 REMARK 465 GLY A 144 REMARK 465 GLU A 145 REMARK 465 LEU A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 CYS A 149 REMARK 465 SER A 150 REMARK 465 PHE A 151 REMARK 465 ASN A 152 REMARK 465 MET A 153 REMARK 465 THR A 154 REMARK 465 THR A 155 REMARK 465 GLU A 156 REMARK 465 LEU A 157 REMARK 465 ARG A 158 REMARK 465 ASP A 159 REMARK 465 LYS A 160 REMARK 465 LYS A 161 REMARK 465 GLN A 162 REMARK 465 LYS A 163 REMARK 465 VAL A 164 REMARK 465 TYR A 165 REMARK 465 SER A 166 REMARK 465 LEU A 167 REMARK 465 PHE A 168 REMARK 465 TYR A 169 REMARK 465 ARG A 170 REMARK 465 LEU A 171 REMARK 465 ASP A 172 REMARK 465 VAL A 173 REMARK 465 VAL A 174 REMARK 465 GLN A 175 REMARK 465 ILE A 176 REMARK 465 ASN A 177 REMARK 465 GLU A 178 REMARK 465 ASN A 179 REMARK 465 GLN A 180 REMARK 465 GLY A 181 REMARK 465 ASN A 182 REMARK 465 ARG A 183 REMARK 465 SER A 184 REMARK 465 ASN A 185 REMARK 465 ASN A 186 REMARK 465 SER A 187 REMARK 465 ASN A 188 REMARK 465 LYS A 189 REMARK 465 GLU A 190 REMARK 465 TYR A 191 REMARK 465 ASN A 302 REMARK 465 ASN A 303 REMARK 465 THR A 304 REMARK 465 ARG A 305 REMARK 465 LYS A 306 REMARK 465 SER A 307 REMARK 465 ILE A 308 REMARK 465 ARG A 309 REMARK 465 ILE A 310 REMARK 465 GLY A 311 REMARK 465 PRO A 312 REMARK 465 GLY A 313 REMARK 465 GLN A 314 REMARK 465 ALA A 315 REMARK 465 PHE A 316 REMARK 465 TYR A 317 REMARK 465 ALA A 318 REMARK 465 THR A 319 REMARK 465 GLY A 320 REMARK 465 ASP A 321 REMARK 465 ILE A 322 REMARK 465 ILE A 323 REMARK 465 GLY A 324 REMARK 465 ASN A 399 REMARK 465 THR A 400 REMARK 465 SER A 401 REMARK 465 VAL A 402 REMARK 465 GLN A 403 REMARK 465 GLY A 404 REMARK 465 SER A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 THR A 408 REMARK 465 GLY A 409 REMARK 465 SER A 410 REMARK 465 ASN A 411 REMARK 465 THR A 461 REMARK 465 ASN A 462 REMARK 465 SER A 463 REMARK 465 LEU B 129 REMARK 465 GLN B 130 REMARK 465 CYS B 131 REMARK 465 THR B 132 REMARK 465 ASN B 133 REMARK 465 VAL B 134 REMARK 465 THR B 135 REMARK 465 ASN B 136 REMARK 465 ASN B 137 REMARK 465 ILE B 138 REMARK 465 THR B 139 REMARK 465 ASP B 140 REMARK 465 ASP B 141 REMARK 465 MET B 142 REMARK 465 ARG B 143 REMARK 465 GLY B 144 REMARK 465 GLU B 145 REMARK 465 LEU B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 CYS B 149 REMARK 465 SER B 150 REMARK 465 PHE B 151 REMARK 465 ASN B 152 REMARK 465 MET B 153 REMARK 465 THR B 154 REMARK 465 THR B 155 REMARK 465 GLU B 156 REMARK 465 LEU B 157 REMARK 465 ARG B 158 REMARK 465 ASP B 159 REMARK 465 LYS B 160 REMARK 465 LYS B 161 REMARK 465 GLN B 162 REMARK 465 LYS B 163 REMARK 465 VAL B 164 REMARK 465 TYR B 165 REMARK 465 SER B 166 REMARK 465 LEU B 167 REMARK 465 PHE B 168 REMARK 465 TYR B 169 REMARK 465 ARG B 170 REMARK 465 LEU B 171 REMARK 465 ASP B 172 REMARK 465 VAL B 173 REMARK 465 VAL B 174 REMARK 465 GLN B 175 REMARK 465 ILE B 176 REMARK 465 ASN B 177 REMARK 465 GLU B 178 REMARK 465 ASN B 179 REMARK 465 GLN B 180 REMARK 465 GLY B 181 REMARK 465 ASN B 182 REMARK 465 ARG B 183 REMARK 465 SER B 184 REMARK 465 ASN B 185 REMARK 465 ASN B 186 REMARK 465 SER B 187 REMARK 465 ASN B 188 REMARK 465 LYS B 189 REMARK 465 GLU B 190 REMARK 465 TYR B 191 REMARK 465 ASN B 302 REMARK 465 ASN B 303 REMARK 465 THR B 304 REMARK 465 ARG B 305 REMARK 465 LYS B 306 REMARK 465 SER B 307 REMARK 465 ILE B 308 REMARK 465 ARG B 309 REMARK 465 ILE B 310 REMARK 465 GLY B 311 REMARK 465 PRO B 312 REMARK 465 GLY B 313 REMARK 465 GLN B 314 REMARK 465 ALA B 315 REMARK 465 PHE B 316 REMARK 465 TYR B 317 REMARK 465 ALA B 318 REMARK 465 THR B 319 REMARK 465 GLY B 320 REMARK 465 ASP B 321 REMARK 465 ILE B 322 REMARK 465 ILE B 323 REMARK 465 GLY B 324 REMARK 465 ASN B 399 REMARK 465 THR B 400 REMARK 465 SER B 401 REMARK 465 VAL B 402 REMARK 465 GLN B 403 REMARK 465 GLY B 404 REMARK 465 SER B 405 REMARK 465 ASN B 406 REMARK 465 SER B 407 REMARK 465 THR B 408 REMARK 465 GLY B 409 REMARK 465 SER B 410 REMARK 465 ASN B 411 REMARK 465 THR B 461 REMARK 465 ASN B 462 REMARK 465 SER B 463 REMARK 465 LEU C 129 REMARK 465 GLN C 130 REMARK 465 CYS C 131 REMARK 465 THR C 132 REMARK 465 ASN C 133 REMARK 465 VAL C 134 REMARK 465 THR C 135 REMARK 465 ASN C 136 REMARK 465 ASN C 137 REMARK 465 ILE C 138 REMARK 465 THR C 139 REMARK 465 ASP C 140 REMARK 465 ASP C 141 REMARK 465 MET C 142 REMARK 465 ARG C 143 REMARK 465 GLY C 144 REMARK 465 GLU C 145 REMARK 465 LEU C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 CYS C 149 REMARK 465 SER C 150 REMARK 465 PHE C 151 REMARK 465 ASN C 152 REMARK 465 MET C 153 REMARK 465 THR C 154 REMARK 465 THR C 155 REMARK 465 GLU C 156 REMARK 465 LEU C 157 REMARK 465 ARG C 158 REMARK 465 ASP C 159 REMARK 465 LYS C 160 REMARK 465 LYS C 161 REMARK 465 GLN C 162 REMARK 465 LYS C 163 REMARK 465 VAL C 164 REMARK 465 TYR C 165 REMARK 465 SER C 166 REMARK 465 LEU C 167 REMARK 465 PHE C 168 REMARK 465 TYR C 169 REMARK 465 ARG C 170 REMARK 465 LEU C 171 REMARK 465 ASP C 172 REMARK 465 VAL C 173 REMARK 465 VAL C 174 REMARK 465 GLN C 175 REMARK 465 ILE C 176 REMARK 465 ASN C 177 REMARK 465 GLU C 178 REMARK 465 ASN C 179 REMARK 465 GLN C 180 REMARK 465 GLY C 181 REMARK 465 ASN C 182 REMARK 465 ARG C 183 REMARK 465 SER C 184 REMARK 465 ASN C 185 REMARK 465 ASN C 186 REMARK 465 SER C 187 REMARK 465 ASN C 188 REMARK 465 LYS C 189 REMARK 465 GLU C 190 REMARK 465 TYR C 191 REMARK 465 ASN C 302 REMARK 465 ASN C 303 REMARK 465 THR C 304 REMARK 465 ARG C 305 REMARK 465 LYS C 306 REMARK 465 SER C 307 REMARK 465 ILE C 308 REMARK 465 ARG C 309 REMARK 465 ILE C 310 REMARK 465 GLY C 311 REMARK 465 PRO C 312 REMARK 465 GLY C 313 REMARK 465 GLN C 314 REMARK 465 ALA C 315 REMARK 465 PHE C 316 REMARK 465 TYR C 317 REMARK 465 ALA C 318 REMARK 465 THR C 319 REMARK 465 GLY C 320 REMARK 465 ASP C 321 REMARK 465 ILE C 322 REMARK 465 ILE C 323 REMARK 465 GLY C 324 REMARK 465 ASN C 399 REMARK 465 THR C 400 REMARK 465 SER C 401 REMARK 465 VAL C 402 REMARK 465 GLN C 403 REMARK 465 GLY C 404 REMARK 465 SER C 405 REMARK 465 ASN C 406 REMARK 465 SER C 407 REMARK 465 THR C 408 REMARK 465 GLY C 409 REMARK 465 SER C 410 REMARK 465 ASN C 411 REMARK 465 THR C 461 REMARK 465 ASN C 462 REMARK 465 SER C 463 REMARK 465 LEU D 544 REMARK 465 LEU D 545 REMARK 465 SER D 546 REMARK 465 GLY D 547 REMARK 465 ILE D 548 REMARK 465 VAL D 549 REMARK 465 GLN D 550 REMARK 465 GLN D 551 REMARK 465 GLN D 552 REMARK 465 SER D 553 REMARK 465 ASN D 554 REMARK 465 LEU D 555 REMARK 465 LEU D 556 REMARK 465 ARG D 557 REMARK 465 ALA D 558 REMARK 465 PRO D 559 REMARK 465 GLU D 560 REMARK 465 ALA D 561 REMARK 465 GLN D 562 REMARK 465 LEU D 660 REMARK 465 GLY E 547 REMARK 465 ILE E 548 REMARK 465 VAL E 549 REMARK 465 GLN E 550 REMARK 465 GLN E 551 REMARK 465 GLN E 552 REMARK 465 SER E 553 REMARK 465 ASN E 554 REMARK 465 LEU E 555 REMARK 465 LEU E 556 REMARK 465 ARG E 557 REMARK 465 ALA E 558 REMARK 465 PRO E 559 REMARK 465 GLU E 560 REMARK 465 ALA E 561 REMARK 465 GLN E 562 REMARK 465 GLN E 563 REMARK 465 HIS E 564 REMARK 465 SER F 546 REMARK 465 GLY F 547 REMARK 465 ILE F 548 REMARK 465 VAL F 549 REMARK 465 GLN F 550 REMARK 465 GLN F 551 REMARK 465 GLN F 552 REMARK 465 SER F 553 REMARK 465 ASN F 554 REMARK 465 LEU F 555 REMARK 465 LEU F 556 REMARK 465 ARG F 557 REMARK 465 ALA F 558 REMARK 465 PRO F 559 REMARK 465 GLU F 560 REMARK 465 ALA F 561 REMARK 465 GLN F 562 REMARK 465 GLN F 563 REMARK 465 HIS F 564 REMARK 465 SER G 112 REMARK 465 SER G 113 REMARK 465 ALA G 114 REMARK 465 SER G 115 REMARK 465 THR G 116 REMARK 465 LYS G 117 REMARK 465 GLY G 118 REMARK 465 PRO G 119 REMARK 465 SER G 120 REMARK 465 VAL G 121 REMARK 465 PHE G 122 REMARK 465 PRO G 123 REMARK 465 LEU G 124 REMARK 465 ALA G 125 REMARK 465 PRO G 126 REMARK 465 SER G 127 REMARK 465 SER G 128 REMARK 465 LYS G 129 REMARK 465 SER G 130 REMARK 465 THR G 131 REMARK 465 SER G 132 REMARK 465 GLY G 133 REMARK 465 GLY G 134 REMARK 465 THR G 135 REMARK 465 ALA G 136 REMARK 465 ALA G 137 REMARK 465 LEU G 138 REMARK 465 GLY G 139 REMARK 465 CYS G 140 REMARK 465 LEU G 141 REMARK 465 VAL G 142 REMARK 465 LYS G 143 REMARK 465 ASP G 144 REMARK 465 TYR G 145 REMARK 465 PHE G 146 REMARK 465 PRO G 147 REMARK 465 GLU G 148 REMARK 465 PRO G 149 REMARK 465 VAL G 150 REMARK 465 THR G 151 REMARK 465 VAL G 152 REMARK 465 SER G 153 REMARK 465 TRP G 154 REMARK 465 ASN G 155 REMARK 465 SER G 156 REMARK 465 GLY G 157 REMARK 465 ALA G 158 REMARK 465 LEU G 159 REMARK 465 THR G 160 REMARK 465 SER G 161 REMARK 465 GLY G 162 REMARK 465 VAL G 163 REMARK 465 HIS G 164 REMARK 465 THR G 165 REMARK 465 PHE G 166 REMARK 465 PRO G 167 REMARK 465 ALA G 168 REMARK 465 VAL G 169 REMARK 465 LEU G 170 REMARK 465 GLN G 171 REMARK 465 SER G 172 REMARK 465 SER G 173 REMARK 465 GLY G 174 REMARK 465 LEU G 175 REMARK 465 TYR G 176 REMARK 465 SER G 177 REMARK 465 LEU G 178 REMARK 465 SER G 179 REMARK 465 SER G 180 REMARK 465 VAL G 181 REMARK 465 VAL G 182 REMARK 465 THR G 183 REMARK 465 VAL G 184 REMARK 465 PRO G 185 REMARK 465 SER G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 LEU G 189 REMARK 465 GLY G 190 REMARK 465 THR G 191 REMARK 465 GLN G 192 REMARK 465 THR G 193 REMARK 465 TYR G 194 REMARK 465 ILE G 195 REMARK 465 CYS G 196 REMARK 465 ASN G 197 REMARK 465 VAL G 198 REMARK 465 ASN G 199 REMARK 465 HIS G 200 REMARK 465 LYS G 201 REMARK 465 PRO G 202 REMARK 465 SER G 203 REMARK 465 ASN G 204 REMARK 465 THR G 205 REMARK 465 LYS G 206 REMARK 465 VAL G 207 REMARK 465 ASP G 208 REMARK 465 LYS G 209 REMARK 465 LYS G 210 REMARK 465 VAL G 211 REMARK 465 GLU G 212 REMARK 465 PRO G 213 REMARK 465 LYS G 214 REMARK 465 ILE H 106 REMARK 465 LYS H 107 REMARK 465 ARG H 108 REMARK 465 THR H 109 REMARK 465 VAL H 110 REMARK 465 ALA H 111 REMARK 465 ALA H 112 REMARK 465 PRO H 113 REMARK 465 SER H 114 REMARK 465 VAL H 115 REMARK 465 PHE H 116 REMARK 465 ILE H 117 REMARK 465 PHE H 118 REMARK 465 PRO H 119 REMARK 465 PRO H 120 REMARK 465 SER H 121 REMARK 465 ASP H 122 REMARK 465 GLU H 123 REMARK 465 GLN H 124 REMARK 465 LEU H 125 REMARK 465 LYS H 126 REMARK 465 SER H 127 REMARK 465 GLY H 128 REMARK 465 THR H 129 REMARK 465 ALA H 130 REMARK 465 SER H 131 REMARK 465 VAL H 132 REMARK 465 VAL H 133 REMARK 465 CYS H 134 REMARK 465 LEU H 135 REMARK 465 LEU H 136 REMARK 465 ASN H 137 REMARK 465 ASN H 138 REMARK 465 PHE H 139 REMARK 465 TYR H 140 REMARK 465 PRO H 141 REMARK 465 ARG H 142 REMARK 465 GLU H 143 REMARK 465 ALA H 144 REMARK 465 LYS H 145 REMARK 465 VAL H 146 REMARK 465 GLN H 147 REMARK 465 TRP H 148 REMARK 465 LYS H 149 REMARK 465 VAL H 150 REMARK 465 ASP H 151 REMARK 465 ASN H 152 REMARK 465 ALA H 153 REMARK 465 LEU H 154 REMARK 465 GLN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ASN H 158 REMARK 465 SER H 159 REMARK 465 GLN H 160 REMARK 465 GLU H 161 REMARK 465 SER H 162 REMARK 465 VAL H 163 REMARK 465 THR H 164 REMARK 465 GLU H 165 REMARK 465 GLN H 166 REMARK 465 ASP H 167 REMARK 465 SER H 168 REMARK 465 LYS H 169 REMARK 465 ASP H 170 REMARK 465 SER H 171 REMARK 465 THR H 172 REMARK 465 TYR H 173 REMARK 465 SER H 174 REMARK 465 LEU H 175 REMARK 465 SER H 176 REMARK 465 SER H 177 REMARK 465 THR H 178 REMARK 465 LEU H 179 REMARK 465 THR H 180 REMARK 465 LEU H 181 REMARK 465 SER H 182 REMARK 465 LYS H 183 REMARK 465 ALA H 184 REMARK 465 ASP H 185 REMARK 465 TYR H 186 REMARK 465 GLU H 187 REMARK 465 LYS H 188 REMARK 465 HIS H 189 REMARK 465 LYS H 190 REMARK 465 VAL H 191 REMARK 465 TYR H 192 REMARK 465 ALA H 193 REMARK 465 CYS H 194 REMARK 465 GLU H 195 REMARK 465 VAL H 196 REMARK 465 THR H 197 REMARK 465 HIS H 198 REMARK 465 GLN H 199 REMARK 465 GLY H 200 REMARK 465 LEU H 201 REMARK 465 SER H 202 REMARK 465 SER H 203 REMARK 465 PRO H 204 REMARK 465 VAL H 205 REMARK 465 THR H 206 REMARK 465 LYS H 207 REMARK 465 SER H 208 REMARK 465 PHE H 209 REMARK 465 ASN H 210 REMARK 465 ARG H 211 REMARK 465 GLY H 212 REMARK 465 VAL I 111 REMARK 465 SER I 112 REMARK 465 SER I 113 REMARK 465 ALA I 114 REMARK 465 SER I 115 REMARK 465 THR I 116 REMARK 465 LYS I 117 REMARK 465 GLY I 118 REMARK 465 PRO I 119 REMARK 465 SER I 120 REMARK 465 VAL I 121 REMARK 465 PHE I 122 REMARK 465 PRO I 123 REMARK 465 LEU I 124 REMARK 465 ALA I 125 REMARK 465 PRO I 126 REMARK 465 SER I 127 REMARK 465 SER I 128 REMARK 465 LYS I 129 REMARK 465 SER I 130 REMARK 465 THR I 131 REMARK 465 SER I 132 REMARK 465 GLY I 133 REMARK 465 GLY I 134 REMARK 465 THR I 135 REMARK 465 ALA I 136 REMARK 465 ALA I 137 REMARK 465 LEU I 138 REMARK 465 GLY I 139 REMARK 465 CYS I 140 REMARK 465 LEU I 141 REMARK 465 VAL I 142 REMARK 465 LYS I 143 REMARK 465 ASP I 144 REMARK 465 TYR I 145 REMARK 465 PHE I 146 REMARK 465 PRO I 147 REMARK 465 GLU I 148 REMARK 465 PRO I 149 REMARK 465 VAL I 150 REMARK 465 THR I 151 REMARK 465 VAL I 152 REMARK 465 SER I 153 REMARK 465 TRP I 154 REMARK 465 ASN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ALA I 158 REMARK 465 LEU I 159 REMARK 465 THR I 160 REMARK 465 SER I 161 REMARK 465 GLY I 162 REMARK 465 VAL I 163 REMARK 465 HIS I 164 REMARK 465 THR I 165 REMARK 465 PHE I 166 REMARK 465 PRO I 167 REMARK 465 ALA I 168 REMARK 465 VAL I 169 REMARK 465 LEU I 170 REMARK 465 GLN I 171 REMARK 465 SER I 172 REMARK 465 SER I 173 REMARK 465 GLY I 174 REMARK 465 LEU I 175 REMARK 465 TYR I 176 REMARK 465 SER I 177 REMARK 465 LEU I 178 REMARK 465 SER I 179 REMARK 465 SER I 180 REMARK 465 VAL I 181 REMARK 465 VAL I 182 REMARK 465 THR I 183 REMARK 465 VAL I 184 REMARK 465 PRO I 185 REMARK 465 SER I 186 REMARK 465 SER I 187 REMARK 465 SER I 188 REMARK 465 LEU I 189 REMARK 465 GLY I 190 REMARK 465 THR I 191 REMARK 465 GLN I 192 REMARK 465 THR I 193 REMARK 465 TYR I 194 REMARK 465 ILE I 195 REMARK 465 CYS I 196 REMARK 465 ASN I 197 REMARK 465 VAL I 198 REMARK 465 ASN I 199 REMARK 465 HIS I 200 REMARK 465 LYS I 201 REMARK 465 PRO I 202 REMARK 465 SER I 203 REMARK 465 ASN I 204 REMARK 465 THR I 205 REMARK 465 LYS I 206 REMARK 465 VAL I 207 REMARK 465 ASP I 208 REMARK 465 LYS I 209 REMARK 465 LYS I 210 REMARK 465 VAL I 211 REMARK 465 GLU I 212 REMARK 465 PRO I 213 REMARK 465 LYS I 214 REMARK 465 ILE J 106 REMARK 465 LYS J 107 REMARK 465 ARG J 108 REMARK 465 THR J 109 REMARK 465 VAL J 110 REMARK 465 ALA J 111 REMARK 465 ALA J 112 REMARK 465 PRO J 113 REMARK 465 SER J 114 REMARK 465 VAL J 115 REMARK 465 PHE J 116 REMARK 465 ILE J 117 REMARK 465 PHE J 118 REMARK 465 PRO J 119 REMARK 465 PRO J 120 REMARK 465 SER J 121 REMARK 465 ASP J 122 REMARK 465 GLU J 123 REMARK 465 GLN J 124 REMARK 465 LEU J 125 REMARK 465 LYS J 126 REMARK 465 SER J 127 REMARK 465 GLY J 128 REMARK 465 THR J 129 REMARK 465 ALA J 130 REMARK 465 SER J 131 REMARK 465 VAL J 132 REMARK 465 VAL J 133 REMARK 465 CYS J 134 REMARK 465 LEU J 135 REMARK 465 LEU J 136 REMARK 465 ASN J 137 REMARK 465 ASN J 138 REMARK 465 PHE J 139 REMARK 465 TYR J 140 REMARK 465 PRO J 141 REMARK 465 ARG J 142 REMARK 465 GLU J 143 REMARK 465 ALA J 144 REMARK 465 LYS J 145 REMARK 465 VAL J 146 REMARK 465 GLN J 147 REMARK 465 TRP J 148 REMARK 465 LYS J 149 REMARK 465 VAL J 150 REMARK 465 ASP J 151 REMARK 465 ASN J 152 REMARK 465 ALA J 153 REMARK 465 LEU J 154 REMARK 465 GLN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ASN J 158 REMARK 465 SER J 159 REMARK 465 GLN J 160 REMARK 465 GLU J 161 REMARK 465 SER J 162 REMARK 465 VAL J 163 REMARK 465 THR J 164 REMARK 465 GLU J 165 REMARK 465 GLN J 166 REMARK 465 ASP J 167 REMARK 465 SER J 168 REMARK 465 LYS J 169 REMARK 465 ASP J 170 REMARK 465 SER J 171 REMARK 465 THR J 172 REMARK 465 TYR J 173 REMARK 465 SER J 174 REMARK 465 LEU J 175 REMARK 465 SER J 176 REMARK 465 SER J 177 REMARK 465 THR J 178 REMARK 465 LEU J 179 REMARK 465 THR J 180 REMARK 465 LEU J 181 REMARK 465 SER J 182 REMARK 465 LYS J 183 REMARK 465 ALA J 184 REMARK 465 ASP J 185 REMARK 465 TYR J 186 REMARK 465 GLU J 187 REMARK 465 LYS J 188 REMARK 465 HIS J 189 REMARK 465 LYS J 190 REMARK 465 VAL J 191 REMARK 465 TYR J 192 REMARK 465 ALA J 193 REMARK 465 CYS J 194 REMARK 465 GLU J 195 REMARK 465 VAL J 196 REMARK 465 THR J 197 REMARK 465 HIS J 198 REMARK 465 GLN J 199 REMARK 465 GLY J 200 REMARK 465 LEU J 201 REMARK 465 SER J 202 REMARK 465 SER J 203 REMARK 465 PRO J 204 REMARK 465 VAL J 205 REMARK 465 THR J 206 REMARK 465 LYS J 207 REMARK 465 SER J 208 REMARK 465 PHE J 209 REMARK 465 ASN J 210 REMARK 465 ARG J 211 REMARK 465 GLY J 212 REMARK 465 VAL K 111 REMARK 465 SER K 112 REMARK 465 SER K 113 REMARK 465 ALA K 114 REMARK 465 SER K 115 REMARK 465 THR K 116 REMARK 465 LYS K 117 REMARK 465 GLY K 118 REMARK 465 PRO K 119 REMARK 465 SER K 120 REMARK 465 VAL K 121 REMARK 465 PHE K 122 REMARK 465 PRO K 123 REMARK 465 LEU K 124 REMARK 465 ALA K 125 REMARK 465 PRO K 126 REMARK 465 SER K 127 REMARK 465 SER K 128 REMARK 465 LYS K 129 REMARK 465 SER K 130 REMARK 465 THR K 131 REMARK 465 SER K 132 REMARK 465 GLY K 133 REMARK 465 GLY K 134 REMARK 465 THR K 135 REMARK 465 ALA K 136 REMARK 465 ALA K 137 REMARK 465 LEU K 138 REMARK 465 GLY K 139 REMARK 465 CYS K 140 REMARK 465 LEU K 141 REMARK 465 VAL K 142 REMARK 465 LYS K 143 REMARK 465 ASP K 144 REMARK 465 TYR K 145 REMARK 465 PHE K 146 REMARK 465 PRO K 147 REMARK 465 GLU K 148 REMARK 465 PRO K 149 REMARK 465 VAL K 150 REMARK 465 THR K 151 REMARK 465 VAL K 152 REMARK 465 SER K 153 REMARK 465 TRP K 154 REMARK 465 ASN K 155 REMARK 465 SER K 156 REMARK 465 GLY K 157 REMARK 465 ALA K 158 REMARK 465 LEU K 159 REMARK 465 THR K 160 REMARK 465 SER K 161 REMARK 465 GLY K 162 REMARK 465 VAL K 163 REMARK 465 HIS K 164 REMARK 465 THR K 165 REMARK 465 PHE K 166 REMARK 465 PRO K 167 REMARK 465 ALA K 168 REMARK 465 VAL K 169 REMARK 465 LEU K 170 REMARK 465 GLN K 171 REMARK 465 SER K 172 REMARK 465 SER K 173 REMARK 465 GLY K 174 REMARK 465 LEU K 175 REMARK 465 TYR K 176 REMARK 465 SER K 177 REMARK 465 LEU K 178 REMARK 465 SER K 179 REMARK 465 SER K 180 REMARK 465 VAL K 181 REMARK 465 VAL K 182 REMARK 465 THR K 183 REMARK 465 VAL K 184 REMARK 465 PRO K 185 REMARK 465 SER K 186 REMARK 465 SER K 187 REMARK 465 SER K 188 REMARK 465 LEU K 189 REMARK 465 GLY K 190 REMARK 465 THR K 191 REMARK 465 GLN K 192 REMARK 465 THR K 193 REMARK 465 TYR K 194 REMARK 465 ILE K 195 REMARK 465 CYS K 196 REMARK 465 ASN K 197 REMARK 465 VAL K 198 REMARK 465 ASN K 199 REMARK 465 HIS K 200 REMARK 465 LYS K 201 REMARK 465 PRO K 202 REMARK 465 SER K 203 REMARK 465 ASN K 204 REMARK 465 THR K 205 REMARK 465 LYS K 206 REMARK 465 VAL K 207 REMARK 465 ASP K 208 REMARK 465 LYS K 209 REMARK 465 LYS K 210 REMARK 465 VAL K 211 REMARK 465 GLU K 212 REMARK 465 PRO K 213 REMARK 465 LYS K 214 REMARK 465 ILE L 106 REMARK 465 LYS L 107 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 PHE M 98 REMARK 465 GLY M 99 REMARK 465 LEU M 100 REMARK 465 THR M 101 REMARK 465 ALA M 102 REMARK 465 ASN M 103 REMARK 465 SER M 104 REMARK 465 ASP M 105 REMARK 465 THR M 106 REMARK 465 HIS M 107 REMARK 465 LEU M 108 REMARK 465 LEU M 109 REMARK 465 GLN M 110 REMARK 465 GLY M 111 REMARK 465 GLN M 112 REMARK 465 SER M 113 REMARK 465 LEU M 114 REMARK 465 THR M 115 REMARK 465 LEU M 116 REMARK 465 THR M 117 REMARK 465 LEU M 118 REMARK 465 GLU M 119 REMARK 465 SER M 120 REMARK 465 PRO M 121 REMARK 465 PRO M 122 REMARK 465 GLY M 123 REMARK 465 SER M 124 REMARK 465 SER M 125 REMARK 465 PRO M 126 REMARK 465 SER M 127 REMARK 465 VAL M 128 REMARK 465 GLN M 129 REMARK 465 CYS M 130 REMARK 465 ARG M 131 REMARK 465 SER M 132 REMARK 465 PRO M 133 REMARK 465 ARG M 134 REMARK 465 GLY M 135 REMARK 465 LYS M 136 REMARK 465 ASN M 137 REMARK 465 ILE M 138 REMARK 465 GLN M 139 REMARK 465 GLY M 140 REMARK 465 GLY M 141 REMARK 465 LYS M 142 REMARK 465 THR M 143 REMARK 465 LEU M 144 REMARK 465 SER M 145 REMARK 465 VAL M 146 REMARK 465 SER M 147 REMARK 465 GLN M 148 REMARK 465 LEU M 149 REMARK 465 GLU M 150 REMARK 465 LEU M 151 REMARK 465 GLN M 152 REMARK 465 ASP M 153 REMARK 465 SER M 154 REMARK 465 GLY M 155 REMARK 465 THR M 156 REMARK 465 TRP M 157 REMARK 465 THR M 158 REMARK 465 CYS M 159 REMARK 465 THR M 160 REMARK 465 VAL M 161 REMARK 465 LEU M 162 REMARK 465 GLN M 163 REMARK 465 ASN M 164 REMARK 465 GLN M 165 REMARK 465 LYS M 166 REMARK 465 LYS M 167 REMARK 465 VAL M 168 REMARK 465 GLU M 169 REMARK 465 PHE M 170 REMARK 465 LYS M 171 REMARK 465 ILE M 172 REMARK 465 ASP M 173 REMARK 465 ILE M 174 REMARK 465 VAL M 175 REMARK 465 VAL M 176 REMARK 465 LEU M 177 REMARK 465 ALA M 178 REMARK 465 PHE M 179 REMARK 465 GLN M 180 REMARK 465 LYS M 181 REMARK 465 PHE N 98 REMARK 465 GLY N 99 REMARK 465 LEU N 100 REMARK 465 THR N 101 REMARK 465 ALA N 102 REMARK 465 ASN N 103 REMARK 465 SER N 104 REMARK 465 ASP N 105 REMARK 465 THR N 106 REMARK 465 HIS N 107 REMARK 465 LEU N 108 REMARK 465 LEU N 109 REMARK 465 GLN N 110 REMARK 465 GLY N 111 REMARK 465 GLN N 112 REMARK 465 SER N 113 REMARK 465 LEU N 114 REMARK 465 THR N 115 REMARK 465 LEU N 116 REMARK 465 THR N 117 REMARK 465 LEU N 118 REMARK 465 GLU N 119 REMARK 465 SER N 120 REMARK 465 PRO N 121 REMARK 465 PRO N 122 REMARK 465 GLY N 123 REMARK 465 SER N 124 REMARK 465 SER N 125 REMARK 465 PRO N 126 REMARK 465 SER N 127 REMARK 465 VAL N 128 REMARK 465 GLN N 129 REMARK 465 CYS N 130 REMARK 465 ARG N 131 REMARK 465 SER N 132 REMARK 465 PRO N 133 REMARK 465 ARG N 134 REMARK 465 GLY N 135 REMARK 465 LYS N 136 REMARK 465 ASN N 137 REMARK 465 ILE N 138 REMARK 465 GLN N 139 REMARK 465 GLY N 140 REMARK 465 GLY N 141 REMARK 465 LYS N 142 REMARK 465 THR N 143 REMARK 465 LEU N 144 REMARK 465 SER N 145 REMARK 465 VAL N 146 REMARK 465 SER N 147 REMARK 465 GLN N 148 REMARK 465 LEU N 149 REMARK 465 GLU N 150 REMARK 465 LEU N 151 REMARK 465 GLN N 152 REMARK 465 ASP N 153 REMARK 465 SER N 154 REMARK 465 GLY N 155 REMARK 465 THR N 156 REMARK 465 TRP N 157 REMARK 465 THR N 158 REMARK 465 CYS N 159 REMARK 465 THR N 160 REMARK 465 VAL N 161 REMARK 465 LEU N 162 REMARK 465 GLN N 163 REMARK 465 ASN N 164 REMARK 465 GLN N 165 REMARK 465 LYS N 166 REMARK 465 LYS N 167 REMARK 465 VAL N 168 REMARK 465 GLU N 169 REMARK 465 PHE N 170 REMARK 465 LYS N 171 REMARK 465 ILE N 172 REMARK 465 ASP N 173 REMARK 465 ILE N 174 REMARK 465 VAL N 175 REMARK 465 VAL N 176 REMARK 465 LEU N 177 REMARK 465 ALA N 178 REMARK 465 PHE N 179 REMARK 465 GLN N 180 REMARK 465 LYS N 181 REMARK 465 PHE O 98 REMARK 465 GLY O 99 REMARK 465 LEU O 100 REMARK 465 THR O 101 REMARK 465 ALA O 102 REMARK 465 ASN O 103 REMARK 465 SER O 104 REMARK 465 ASP O 105 REMARK 465 THR O 106 REMARK 465 HIS O 107 REMARK 465 LEU O 108 REMARK 465 LEU O 109 REMARK 465 GLN O 110 REMARK 465 GLY O 111 REMARK 465 GLN O 112 REMARK 465 SER O 113 REMARK 465 LEU O 114 REMARK 465 THR O 115 REMARK 465 LEU O 116 REMARK 465 THR O 117 REMARK 465 LEU O 118 REMARK 465 GLU O 119 REMARK 465 SER O 120 REMARK 465 PRO O 121 REMARK 465 PRO O 122 REMARK 465 GLY O 123 REMARK 465 SER O 124 REMARK 465 SER O 125 REMARK 465 PRO O 126 REMARK 465 SER O 127 REMARK 465 VAL O 128 REMARK 465 GLN O 129 REMARK 465 CYS O 130 REMARK 465 ARG O 131 REMARK 465 SER O 132 REMARK 465 PRO O 133 REMARK 465 ARG O 134 REMARK 465 GLY O 135 REMARK 465 LYS O 136 REMARK 465 ASN O 137 REMARK 465 ILE O 138 REMARK 465 GLN O 139 REMARK 465 GLY O 140 REMARK 465 GLY O 141 REMARK 465 LYS O 142 REMARK 465 THR O 143 REMARK 465 LEU O 144 REMARK 465 SER O 145 REMARK 465 VAL O 146 REMARK 465 SER O 147 REMARK 465 GLN O 148 REMARK 465 LEU O 149 REMARK 465 GLU O 150 REMARK 465 LEU O 151 REMARK 465 GLN O 152 REMARK 465 ASP O 153 REMARK 465 SER O 154 REMARK 465 GLY O 155 REMARK 465 THR O 156 REMARK 465 TRP O 157 REMARK 465 THR O 158 REMARK 465 CYS O 159 REMARK 465 THR O 160 REMARK 465 VAL O 161 REMARK 465 LEU O 162 REMARK 465 GLN O 163 REMARK 465 ASN O 164 REMARK 465 GLN O 165 REMARK 465 LYS O 166 REMARK 465 LYS O 167 REMARK 465 VAL O 168 REMARK 465 GLU O 169 REMARK 465 PHE O 170 REMARK 465 LYS O 171 REMARK 465 ILE O 172 REMARK 465 ASP O 173 REMARK 465 ILE O 174 REMARK 465 VAL O 175 REMARK 465 VAL O 176 REMARK 465 LEU O 177 REMARK 465 ALA O 178 REMARK 465 PHE O 179 REMARK 465 GLN O 180 REMARK 465 LYS O 181 REMARK 465 GLU P 105 REMARK 465 ILE P 106 REMARK 465 LYS P 107 REMARK 465 ARG P 108 REMARK 465 THR P 109 REMARK 465 VAL P 110 REMARK 465 ALA P 111 REMARK 465 ALA P 112 REMARK 465 PRO P 113 REMARK 465 SER P 114 REMARK 465 VAL P 115 REMARK 465 PHE P 116 REMARK 465 ILE P 117 REMARK 465 PHE P 118 REMARK 465 PRO P 119 REMARK 465 PRO P 120 REMARK 465 SER P 121 REMARK 465 ASP P 122 REMARK 465 GLU P 123 REMARK 465 GLN P 124 REMARK 465 LEU P 125 REMARK 465 LYS P 126 REMARK 465 SER P 127 REMARK 465 GLY P 128 REMARK 465 THR P 129 REMARK 465 ALA P 130 REMARK 465 SER P 131 REMARK 465 VAL P 132 REMARK 465 VAL P 133 REMARK 465 CYS P 134 REMARK 465 LEU P 135 REMARK 465 LEU P 136 REMARK 465 ASN P 137 REMARK 465 ASN P 138 REMARK 465 PHE P 139 REMARK 465 TYR P 140 REMARK 465 PRO P 141 REMARK 465 ARG P 142 REMARK 465 GLU P 143 REMARK 465 ALA P 144 REMARK 465 LYS P 145 REMARK 465 VAL P 146 REMARK 465 GLN P 147 REMARK 465 TRP P 148 REMARK 465 LYS P 149 REMARK 465 VAL P 150 REMARK 465 ASP P 151 REMARK 465 ASN P 152 REMARK 465 ALA P 153 REMARK 465 LEU P 154 REMARK 465 GLN P 155 REMARK 465 SER P 156 REMARK 465 GLY P 157 REMARK 465 ASN P 158 REMARK 465 SER P 159 REMARK 465 GLN P 160 REMARK 465 GLU P 161 REMARK 465 SER P 162 REMARK 465 VAL P 163 REMARK 465 THR P 164 REMARK 465 GLU P 165 REMARK 465 GLN P 166 REMARK 465 ASP P 167 REMARK 465 SER P 168 REMARK 465 LYS P 169 REMARK 465 ASP P 170 REMARK 465 SER P 171 REMARK 465 THR P 172 REMARK 465 TYR P 173 REMARK 465 SER P 174 REMARK 465 LEU P 175 REMARK 465 SER P 176 REMARK 465 SER P 177 REMARK 465 THR P 178 REMARK 465 LEU P 179 REMARK 465 THR P 180 REMARK 465 LEU P 181 REMARK 465 SER P 182 REMARK 465 LYS P 183 REMARK 465 ALA P 184 REMARK 465 ASP P 185 REMARK 465 TYR P 186 REMARK 465 GLU P 187 REMARK 465 LYS P 188 REMARK 465 HIS P 189 REMARK 465 LYS P 190 REMARK 465 VAL P 191 REMARK 465 TYR P 192 REMARK 465 ALA P 193 REMARK 465 CYS P 194 REMARK 465 GLU P 195 REMARK 465 VAL P 196 REMARK 465 THR P 197 REMARK 465 HIS P 198 REMARK 465 GLN P 199 REMARK 465 GLY P 200 REMARK 465 LEU P 201 REMARK 465 SER P 202 REMARK 465 SER P 203 REMARK 465 PRO P 204 REMARK 465 VAL P 205 REMARK 465 THR P 206 REMARK 465 LYS P 207 REMARK 465 SER P 208 REMARK 465 PHE P 209 REMARK 465 ASN P 210 REMARK 465 ARG P 211 REMARK 465 GLY P 212 REMARK 465 SER Q 112 REMARK 465 SER Q 113 REMARK 465 ALA Q 114 REMARK 465 SER Q 115 REMARK 465 THR Q 116 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 LYS Q 129 REMARK 465 SER Q 130 REMARK 465 THR Q 131 REMARK 465 SER Q 132 REMARK 465 GLY Q 133 REMARK 465 GLY Q 134 REMARK 465 THR Q 135 REMARK 465 ALA Q 136 REMARK 465 ALA Q 137 REMARK 465 LEU Q 138 REMARK 465 GLY Q 139 REMARK 465 CYS Q 140 REMARK 465 LEU Q 141 REMARK 465 VAL Q 142 REMARK 465 LYS Q 143 REMARK 465 ASP Q 144 REMARK 465 TYR Q 145 REMARK 465 PHE Q 146 REMARK 465 PRO Q 147 REMARK 465 GLU Q 148 REMARK 465 PRO Q 149 REMARK 465 VAL Q 150 REMARK 465 THR Q 151 REMARK 465 VAL Q 152 REMARK 465 SER Q 153 REMARK 465 TRP Q 154 REMARK 465 ASN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ALA Q 158 REMARK 465 LEU Q 159 REMARK 465 THR Q 160 REMARK 465 SER Q 161 REMARK 465 GLY Q 162 REMARK 465 VAL Q 163 REMARK 465 HIS Q 164 REMARK 465 THR Q 165 REMARK 465 PHE Q 166 REMARK 465 PRO Q 167 REMARK 465 ALA Q 168 REMARK 465 VAL Q 169 REMARK 465 LEU Q 170 REMARK 465 GLN Q 171 REMARK 465 SER Q 172 REMARK 465 SER Q 173 REMARK 465 GLY Q 174 REMARK 465 LEU Q 175 REMARK 465 TYR Q 176 REMARK 465 SER Q 177 REMARK 465 LEU Q 178 REMARK 465 SER Q 179 REMARK 465 SER Q 180 REMARK 465 VAL Q 181 REMARK 465 VAL Q 182 REMARK 465 THR Q 183 REMARK 465 VAL Q 184 REMARK 465 PRO Q 185 REMARK 465 SER Q 186 REMARK 465 SER Q 187 REMARK 465 SER Q 188 REMARK 465 LEU Q 189 REMARK 465 GLY Q 190 REMARK 465 THR Q 191 REMARK 465 GLN Q 192 REMARK 465 THR Q 193 REMARK 465 TYR Q 194 REMARK 465 ILE Q 195 REMARK 465 CYS Q 196 REMARK 465 ASN Q 197 REMARK 465 VAL Q 198 REMARK 465 ASN Q 199 REMARK 465 HIS Q 200 REMARK 465 LYS Q 201 REMARK 465 PRO Q 202 REMARK 465 SER Q 203 REMARK 465 ASN Q 204 REMARK 465 THR Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 ASP Q 208 REMARK 465 LYS Q 209 REMARK 465 LYS Q 210 REMARK 465 VAL Q 211 REMARK 465 GLU Q 212 REMARK 465 PRO Q 213 REMARK 465 LYS Q 214 REMARK 465 GLU R 105 REMARK 465 ILE R 106 REMARK 465 LYS R 107 REMARK 465 ARG R 108 REMARK 465 THR R 109 REMARK 465 VAL R 110 REMARK 465 ALA R 111 REMARK 465 ALA R 112 REMARK 465 PRO R 113 REMARK 465 SER R 114 REMARK 465 VAL R 115 REMARK 465 PHE R 116 REMARK 465 ILE R 117 REMARK 465 PHE R 118 REMARK 465 PRO R 119 REMARK 465 PRO R 120 REMARK 465 SER R 121 REMARK 465 ASP R 122 REMARK 465 GLU R 123 REMARK 465 GLN R 124 REMARK 465 LEU R 125 REMARK 465 LYS R 126 REMARK 465 SER R 127 REMARK 465 GLY R 128 REMARK 465 THR R 129 REMARK 465 ALA R 130 REMARK 465 SER R 131 REMARK 465 VAL R 132 REMARK 465 VAL R 133 REMARK 465 CYS R 134 REMARK 465 LEU R 135 REMARK 465 LEU R 136 REMARK 465 ASN R 137 REMARK 465 ASN R 138 REMARK 465 PHE R 139 REMARK 465 TYR R 140 REMARK 465 PRO R 141 REMARK 465 ARG R 142 REMARK 465 GLU R 143 REMARK 465 ALA R 144 REMARK 465 LYS R 145 REMARK 465 VAL R 146 REMARK 465 GLN R 147 REMARK 465 TRP R 148 REMARK 465 LYS R 149 REMARK 465 VAL R 150 REMARK 465 ASP R 151 REMARK 465 ASN R 152 REMARK 465 ALA R 153 REMARK 465 LEU R 154 REMARK 465 GLN R 155 REMARK 465 SER R 156 REMARK 465 GLY R 157 REMARK 465 ASN R 158 REMARK 465 SER R 159 REMARK 465 GLN R 160 REMARK 465 GLU R 161 REMARK 465 SER R 162 REMARK 465 VAL R 163 REMARK 465 THR R 164 REMARK 465 GLU R 165 REMARK 465 GLN R 166 REMARK 465 ASP R 167 REMARK 465 SER R 168 REMARK 465 LYS R 169 REMARK 465 ASP R 170 REMARK 465 SER R 171 REMARK 465 THR R 172 REMARK 465 TYR R 173 REMARK 465 SER R 174 REMARK 465 LEU R 175 REMARK 465 SER R 176 REMARK 465 SER R 177 REMARK 465 THR R 178 REMARK 465 LEU R 179 REMARK 465 THR R 180 REMARK 465 LEU R 181 REMARK 465 SER R 182 REMARK 465 LYS R 183 REMARK 465 ALA R 184 REMARK 465 ASP R 185 REMARK 465 TYR R 186 REMARK 465 GLU R 187 REMARK 465 LYS R 188 REMARK 465 HIS R 189 REMARK 465 LYS R 190 REMARK 465 VAL R 191 REMARK 465 TYR R 192 REMARK 465 ALA R 193 REMARK 465 CYS R 194 REMARK 465 GLU R 195 REMARK 465 VAL R 196 REMARK 465 THR R 197 REMARK 465 HIS R 198 REMARK 465 GLN R 199 REMARK 465 GLY R 200 REMARK 465 LEU R 201 REMARK 465 SER R 202 REMARK 465 SER R 203 REMARK 465 PRO R 204 REMARK 465 VAL R 205 REMARK 465 THR R 206 REMARK 465 LYS R 207 REMARK 465 SER R 208 REMARK 465 PHE R 209 REMARK 465 ASN R 210 REMARK 465 ARG R 211 REMARK 465 GLY R 212 REMARK 465 SER S 112 REMARK 465 SER S 113 REMARK 465 ALA S 114 REMARK 465 SER S 115 REMARK 465 THR S 116 REMARK 465 LYS S 117 REMARK 465 GLY S 118 REMARK 465 PRO S 119 REMARK 465 SER S 120 REMARK 465 VAL S 121 REMARK 465 PHE S 122 REMARK 465 PRO S 123 REMARK 465 LEU S 124 REMARK 465 ALA S 125 REMARK 465 PRO S 126 REMARK 465 SER S 127 REMARK 465 SER S 128 REMARK 465 LYS S 129 REMARK 465 SER S 130 REMARK 465 THR S 131 REMARK 465 SER S 132 REMARK 465 GLY S 133 REMARK 465 GLY S 134 REMARK 465 THR S 135 REMARK 465 ALA S 136 REMARK 465 ALA S 137 REMARK 465 LEU S 138 REMARK 465 GLY S 139 REMARK 465 CYS S 140 REMARK 465 LEU S 141 REMARK 465 VAL S 142 REMARK 465 LYS S 143 REMARK 465 ASP S 144 REMARK 465 TYR S 145 REMARK 465 PHE S 146 REMARK 465 PRO S 147 REMARK 465 GLU S 148 REMARK 465 PRO S 149 REMARK 465 VAL S 150 REMARK 465 THR S 151 REMARK 465 VAL S 152 REMARK 465 SER S 153 REMARK 465 TRP S 154 REMARK 465 ASN S 155 REMARK 465 SER S 156 REMARK 465 GLY S 157 REMARK 465 ALA S 158 REMARK 465 LEU S 159 REMARK 465 THR S 160 REMARK 465 SER S 161 REMARK 465 GLY S 162 REMARK 465 VAL S 163 REMARK 465 HIS S 164 REMARK 465 THR S 165 REMARK 465 PHE S 166 REMARK 465 PRO S 167 REMARK 465 ALA S 168 REMARK 465 VAL S 169 REMARK 465 LEU S 170 REMARK 465 GLN S 171 REMARK 465 SER S 172 REMARK 465 SER S 173 REMARK 465 GLY S 174 REMARK 465 LEU S 175 REMARK 465 TYR S 176 REMARK 465 SER S 177 REMARK 465 LEU S 178 REMARK 465 SER S 179 REMARK 465 SER S 180 REMARK 465 VAL S 181 REMARK 465 VAL S 182 REMARK 465 THR S 183 REMARK 465 VAL S 184 REMARK 465 PRO S 185 REMARK 465 SER S 186 REMARK 465 SER S 187 REMARK 465 SER S 188 REMARK 465 LEU S 189 REMARK 465 GLY S 190 REMARK 465 THR S 191 REMARK 465 GLN S 192 REMARK 465 THR S 193 REMARK 465 TYR S 194 REMARK 465 ILE S 195 REMARK 465 CYS S 196 REMARK 465 ASN S 197 REMARK 465 VAL S 198 REMARK 465 ASN S 199 REMARK 465 HIS S 200 REMARK 465 LYS S 201 REMARK 465 PRO S 202 REMARK 465 SER S 203 REMARK 465 ASN S 204 REMARK 465 THR S 205 REMARK 465 LYS S 206 REMARK 465 VAL S 207 REMARK 465 ASP S 208 REMARK 465 LYS S 209 REMARK 465 LYS S 210 REMARK 465 VAL S 211 REMARK 465 GLU S 212 REMARK 465 PRO S 213 REMARK 465 LYS S 214 REMARK 465 GLU T 105 REMARK 465 ILE T 106 REMARK 465 LYS T 107 REMARK 465 ARG T 108 REMARK 465 THR T 109 REMARK 465 VAL T 110 REMARK 465 ALA T 111 REMARK 465 ALA T 112 REMARK 465 PRO T 113 REMARK 465 SER T 114 REMARK 465 VAL T 115 REMARK 465 PHE T 116 REMARK 465 ILE T 117 REMARK 465 PHE T 118 REMARK 465 PRO T 119 REMARK 465 PRO T 120 REMARK 465 SER T 121 REMARK 465 ASP T 122 REMARK 465 GLU T 123 REMARK 465 GLN T 124 REMARK 465 LEU T 125 REMARK 465 LYS T 126 REMARK 465 SER T 127 REMARK 465 GLY T 128 REMARK 465 THR T 129 REMARK 465 ALA T 130 REMARK 465 SER T 131 REMARK 465 VAL T 132 REMARK 465 VAL T 133 REMARK 465 CYS T 134 REMARK 465 LEU T 135 REMARK 465 LEU T 136 REMARK 465 ASN T 137 REMARK 465 ASN T 138 REMARK 465 PHE T 139 REMARK 465 TYR T 140 REMARK 465 PRO T 141 REMARK 465 ARG T 142 REMARK 465 GLU T 143 REMARK 465 ALA T 144 REMARK 465 LYS T 145 REMARK 465 VAL T 146 REMARK 465 GLN T 147 REMARK 465 TRP T 148 REMARK 465 LYS T 149 REMARK 465 VAL T 150 REMARK 465 ASP T 151 REMARK 465 ASN T 152 REMARK 465 ALA T 153 REMARK 465 LEU T 154 REMARK 465 GLN T 155 REMARK 465 SER T 156 REMARK 465 GLY T 157 REMARK 465 ASN T 158 REMARK 465 SER T 159 REMARK 465 GLN T 160 REMARK 465 GLU T 161 REMARK 465 SER T 162 REMARK 465 VAL T 163 REMARK 465 THR T 164 REMARK 465 GLU T 165 REMARK 465 GLN T 166 REMARK 465 ASP T 167 REMARK 465 SER T 168 REMARK 465 LYS T 169 REMARK 465 ASP T 170 REMARK 465 SER T 171 REMARK 465 THR T 172 REMARK 465 TYR T 173 REMARK 465 SER T 174 REMARK 465 LEU T 175 REMARK 465 SER T 176 REMARK 465 SER T 177 REMARK 465 THR T 178 REMARK 465 LEU T 179 REMARK 465 THR T 180 REMARK 465 LEU T 181 REMARK 465 SER T 182 REMARK 465 LYS T 183 REMARK 465 ALA T 184 REMARK 465 ASP T 185 REMARK 465 TYR T 186 REMARK 465 GLU T 187 REMARK 465 LYS T 188 REMARK 465 HIS T 189 REMARK 465 LYS T 190 REMARK 465 VAL T 191 REMARK 465 TYR T 192 REMARK 465 ALA T 193 REMARK 465 CYS T 194 REMARK 465 GLU T 195 REMARK 465 VAL T 196 REMARK 465 THR T 197 REMARK 465 HIS T 198 REMARK 465 GLN T 199 REMARK 465 GLY T 200 REMARK 465 LEU T 201 REMARK 465 SER T 202 REMARK 465 SER T 203 REMARK 465 PRO T 204 REMARK 465 VAL T 205 REMARK 465 THR T 206 REMARK 465 LYS T 207 REMARK 465 SER T 208 REMARK 465 PHE T 209 REMARK 465 ASN T 210 REMARK 465 ARG T 211 REMARK 465 GLY T 212 REMARK 465 SER U 112 REMARK 465 SER U 113 REMARK 465 ALA U 114 REMARK 465 SER U 115 REMARK 465 THR U 116 REMARK 465 LYS U 117 REMARK 465 GLY U 118 REMARK 465 PRO U 119 REMARK 465 SER U 120 REMARK 465 VAL U 121 REMARK 465 PHE U 122 REMARK 465 PRO U 123 REMARK 465 LEU U 124 REMARK 465 ALA U 125 REMARK 465 PRO U 126 REMARK 465 SER U 127 REMARK 465 SER U 128 REMARK 465 LYS U 129 REMARK 465 SER U 130 REMARK 465 THR U 131 REMARK 465 SER U 132 REMARK 465 GLY U 133 REMARK 465 GLY U 134 REMARK 465 THR U 135 REMARK 465 ALA U 136 REMARK 465 ALA U 137 REMARK 465 LEU U 138 REMARK 465 GLY U 139 REMARK 465 CYS U 140 REMARK 465 LEU U 141 REMARK 465 VAL U 142 REMARK 465 LYS U 143 REMARK 465 ASP U 144 REMARK 465 TYR U 145 REMARK 465 PHE U 146 REMARK 465 PRO U 147 REMARK 465 GLU U 148 REMARK 465 PRO U 149 REMARK 465 VAL U 150 REMARK 465 THR U 151 REMARK 465 VAL U 152 REMARK 465 SER U 153 REMARK 465 TRP U 154 REMARK 465 ASN U 155 REMARK 465 SER U 156 REMARK 465 GLY U 157 REMARK 465 ALA U 158 REMARK 465 LEU U 159 REMARK 465 THR U 160 REMARK 465 SER U 161 REMARK 465 GLY U 162 REMARK 465 VAL U 163 REMARK 465 HIS U 164 REMARK 465 THR U 165 REMARK 465 PHE U 166 REMARK 465 PRO U 167 REMARK 465 ALA U 168 REMARK 465 VAL U 169 REMARK 465 LEU U 170 REMARK 465 GLN U 171 REMARK 465 SER U 172 REMARK 465 SER U 173 REMARK 465 GLY U 174 REMARK 465 LEU U 175 REMARK 465 TYR U 176 REMARK 465 SER U 177 REMARK 465 LEU U 178 REMARK 465 SER U 179 REMARK 465 SER U 180 REMARK 465 VAL U 181 REMARK 465 VAL U 182 REMARK 465 THR U 183 REMARK 465 VAL U 184 REMARK 465 PRO U 185 REMARK 465 SER U 186 REMARK 465 SER U 187 REMARK 465 SER U 188 REMARK 465 LEU U 189 REMARK 465 GLY U 190 REMARK 465 THR U 191 REMARK 465 GLN U 192 REMARK 465 THR U 193 REMARK 465 TYR U 194 REMARK 465 ILE U 195 REMARK 465 CYS U 196 REMARK 465 ASN U 197 REMARK 465 VAL U 198 REMARK 465 ASN U 199 REMARK 465 HIS U 200 REMARK 465 LYS U 201 REMARK 465 PRO U 202 REMARK 465 SER U 203 REMARK 465 ASN U 204 REMARK 465 THR U 205 REMARK 465 LYS U 206 REMARK 465 VAL U 207 REMARK 465 ASP U 208 REMARK 465 LYS U 209 REMARK 465 LYS U 210 REMARK 465 VAL U 211 REMARK 465 GLU U 212 REMARK 465 PRO U 213 REMARK 465 LYS U 214 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 GLU A 49 CG CD OE1 OE2 REMARK 470 ASP A 57 CG OD1 OD2 REMARK 470 GLU A 87 CG CD OE1 OE2 REMARK 470 LYS A 97 CG CD CE NZ REMARK 470 LYS A 117 CG CD CE NZ REMARK 470 ARG A 192 CG CD NE CZ NH1 NH2 REMARK 470 LEU A 193 CG CD1 CD2 REMARK 470 GLN A 203 CG CD OE1 NE2 REMARK 470 VAL A 208 CG1 CG2 REMARK 470 GLU A 211 CG CD OE1 OE2 REMARK 470 LYS A 231 CG CD CE NZ REMARK 470 LYS A 232 CG CD CE NZ REMARK 470 GLU A 267 CG CD OE1 OE2 REMARK 470 GLU A 268 CG CD OE1 OE2 REMARK 470 GLU A 269 CG CD OE1 OE2 REMARK 470 GLU A 275 CG CD OE1 OE2 REMARK 470 ILE A 358 CG1 CG2 CD1 REMARK 470 GLU A 370 CG CD OE1 OE2 REMARK 470 GLU A 381 CG CD OE1 OE2 REMARK 470 ILE A 396 CG1 CG2 CD1 REMARK 470 GLN A 440 CG CD OE1 NE2 REMARK 470 ASP A 457 CG OD1 OD2 REMARK 470 THR A 465 CG2 REMARK 470 GLU A 466 CD OE1 OE2 REMARK 470 THR A 467 OG1 CG2 REMARK 470 ASP A 474 CG OD1 OD2 REMARK 470 LYS A 502 CG CD CE NZ REMARK 470 GLU B 49 CG CD OE1 OE2 REMARK 470 ASP B 57 CG OD1 OD2 REMARK 470 GLU B 87 CG CD OE1 OE2 REMARK 470 LYS B 97 CG CD CE NZ REMARK 470 LYS B 117 CG CD CE NZ REMARK 470 ARG B 192 CG CD NE CZ NH1 NH2 REMARK 470 LEU B 193 CG CD1 CD2 REMARK 470 GLN B 203 CG CD OE1 NE2 REMARK 470 VAL B 208 CG1 CG2 REMARK 470 GLU B 211 CG CD OE1 OE2 REMARK 470 LYS B 231 CG CD CE NZ REMARK 470 LYS B 232 CG CD CE NZ REMARK 470 GLU B 267 CG CD OE1 OE2 REMARK 470 GLU B 268 CG CD OE1 OE2 REMARK 470 GLU B 269 CG CD OE1 OE2 REMARK 470 GLU B 275 CG CD OE1 OE2 REMARK 470 ILE B 358 CG1 CG2 CD1 REMARK 470 GLU B 370 CG CD OE1 OE2 REMARK 470 GLU B 381 CG CD OE1 OE2 REMARK 470 ILE B 396 CG1 CG2 CD1 REMARK 470 GLN B 440 CG CD OE1 NE2 REMARK 470 ASP B 457 CG OD1 OD2 REMARK 470 THR B 465 CG2 REMARK 470 GLU B 466 CD OE1 OE2 REMARK 470 THR B 467 OG1 CG2 REMARK 470 ASP B 474 CG OD1 OD2 REMARK 470 LYS B 502 CG CD CE NZ REMARK 470 GLU C 49 CG CD OE1 OE2 REMARK 470 ASP C 57 CG OD1 OD2 REMARK 470 GLU C 87 CG CD OE1 OE2 REMARK 470 LYS C 97 CG CD CE NZ REMARK 470 LYS C 117 CG CD CE NZ REMARK 470 ARG C 192 CG CD NE CZ NH1 NH2 REMARK 470 LEU C 193 CG CD1 CD2 REMARK 470 GLN C 203 CG CD OE1 NE2 REMARK 470 VAL C 208 CG1 CG2 REMARK 470 GLU C 211 CG CD OE1 OE2 REMARK 470 LYS C 231 CG CD CE NZ REMARK 470 LYS C 232 CG CD CE NZ REMARK 470 GLU C 267 CG CD OE1 OE2 REMARK 470 GLU C 268 CG CD OE1 OE2 REMARK 470 GLU C 269 CG CD OE1 OE2 REMARK 470 GLU C 275 CG CD OE1 OE2 REMARK 470 ILE C 358 CG1 CG2 CD1 REMARK 470 GLU C 370 CG CD OE1 OE2 REMARK 470 GLU C 381 CG CD OE1 OE2 REMARK 470 ILE C 396 CG1 CG2 CD1 REMARK 470 GLN C 440 CG CD OE1 NE2 REMARK 470 ASP C 457 CG OD1 OD2 REMARK 470 THR C 465 CG2 REMARK 470 GLU C 466 CD OE1 OE2 REMARK 470 THR C 467 OG1 CG2 REMARK 470 ASP C 474 CG OD1 OD2 REMARK 470 LYS C 502 CG CD CE NZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS B 126 CA - CB - SG ANGL. DEV. = 8.7 DEGREES REMARK 500 CYS B 247 CA - CB - SG ANGL. DEV. = 11.4 DEGREES REMARK 500 CYS C 247 CA - CB - SG ANGL. DEV. = 10.1 DEGREES REMARK 500 LEU L 73 CA - CB - CG ANGL. DEV. = 14.8 DEGREES REMARK 500 ASP M 88 CB - CG - OD1 ANGL. DEV. = 5.7 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LYS A 65 -1.06 69.52 REMARK 500 SER A 115 -60.22 -101.22 REMARK 500 GLN A 258 -6.61 68.16 REMARK 500 ARG A 500 40.84 -109.18 REMARK 500 LEU B 125 -70.97 -96.83 REMARK 500 CYS B 126 62.94 34.99 REMARK 500 GLN B 258 -8.86 74.42 REMARK 500 GLU B 267 -61.04 -94.99 REMARK 500 ARG B 327 59.46 -99.67 REMARK 500 ARG B 500 40.61 -97.46 REMARK 500 THR C 63 40.67 -99.17 REMARK 500 LYS C 65 -5.71 73.67 REMARK 500 SER C 241 76.99 -100.56 REMARK 500 GLN C 258 -9.88 72.41 REMARK 500 ARG C 327 57.53 -96.67 REMARK 500 LEU D 523 50.53 -97.83 REMARK 500 THR D 569 -30.22 -131.03 REMARK 500 SER D 599 -88.88 55.87 REMARK 500 THR E 536 47.80 -93.14 REMARK 500 THR E 606 -169.11 -124.51 REMARK 500 GLN E 650 -62.92 -96.26 REMARK 500 ASN E 656 -2.50 68.80 REMARK 500 TRP F 614 55.61 -91.67 REMARK 500 GLN F 650 -94.69 59.48 REMARK 500 ASN F 656 -5.80 72.63 REMARK 500 LEU G 48 -64.39 -97.44 REMARK 500 TYR G 97 70.04 63.10 REMARK 500 VAL G 100C -50.75 -120.95 REMARK 500 ARG H 30 -99.26 59.65 REMARK 500 ASN H 31 15.02 -141.57 REMARK 500 ALA H 51 -3.57 64.93 REMARK 500 SER H 52 -14.09 -140.43 REMARK 500 TYR I 97 66.25 61.02 REMARK 500 VAL I 100C -52.11 -121.34 REMARK 500 ARG J 30 -100.14 60.35 REMARK 500 ASN J 31 11.28 -143.18 REMARK 500 ALA J 51 -3.24 65.56 REMARK 500 LEU K 48 -62.57 -93.89 REMARK 500 TYR K 97 64.69 61.03 REMARK 500 VAL K 100C -58.08 -121.73 REMARK 500 ARG L 30 -100.24 56.91 REMARK 500 LEU L 47 -54.47 -120.40 REMARK 500 ALA L 51 -1.04 63.23 REMARK 500 SER L 52 -2.35 -141.70 REMARK 500 MET L 91 23.32 -146.04 REMARK 500 GLN M 40 76.92 -101.96 REMARK 500 ASP M 88 42.09 35.66 REMARK 500 ILE N 36 -62.98 -109.47 REMARK 500 LEU N 51 32.37 -98.73 REMARK 500 LEU O 51 33.53 -94.72 REMARK 500 REMARK 500 THIS ENTRY HAS 63 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 TRP T 94 PRO T 95 117.35 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-46653 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-46655 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF PARTIALLY OPEN HIV-1 BG505 SOSIP.664 ENV BOUND REMARK 900 TO 3-SCD4, 3-17B FAB AND 3-VRC34.01 FAB DBREF 9D90 A 33 503 UNP Q2N0S5 Q2N0S5_HV1 32 500 DBREF 9D90 B 33 503 UNP Q2N0S5 Q2N0S5_HV1 32 500 DBREF 9D90 C 33 503 UNP Q2N0S5 Q2N0S5_HV1 32 500 DBREF 9D90 D 512 660 UNP Q2N0S5 Q2N0S5_HV1 509 657 DBREF 9D90 E 512 660 UNP Q2N0S5 Q2N0S5_HV1 509 657 DBREF 9D90 F 512 660 UNP Q2N0S5 Q2N0S5_HV1 509 657 DBREF 9D90 G 1 214 PDB 9D90 9D90 1 214 DBREF 9D90 H 1 212 PDB 9D90 9D90 1 212 DBREF 9D90 I 1 214 PDB 9D90 9D90 1 214 DBREF 9D90 J 1 212 PDB 9D90 9D90 1 212 DBREF 9D90 K 1 214 PDB 9D90 9D90 1 214 DBREF 9D90 L 1 212 PDB 9D90 9D90 1 212 DBREF 9D90 M 1 181 UNP P01730 CD4_HUMAN 26 206 DBREF 9D90 N 1 181 UNP P01730 CD4_HUMAN 26 206 DBREF 9D90 O 1 181 UNP P01730 CD4_HUMAN 26 206 DBREF 9D90 P 1 212 PDB 9D90 9D90 1 212 DBREF 9D90 Q 1 214 PDB 9D90 9D90 1 214 DBREF 9D90 R 1 212 PDB 9D90 9D90 1 212 DBREF 9D90 S 1 214 PDB 9D90 9D90 1 214 DBREF 9D90 T 1 212 PDB 9D90 9D90 1 212 DBREF 9D90 U 1 214 PDB 9D90 9D90 1 214 SEQADV 9D90 ASN A 332 UNP Q2N0S5 THR 330 ENGINEERED MUTATION SEQADV 9D90 CYS A 501 UNP Q2N0S5 ALA 498 ENGINEERED MUTATION SEQADV 9D90 ASN B 332 UNP Q2N0S5 THR 330 ENGINEERED MUTATION SEQADV 9D90 CYS B 501 UNP Q2N0S5 ALA 498 ENGINEERED MUTATION SEQADV 9D90 ASN C 332 UNP Q2N0S5 THR 330 ENGINEERED MUTATION SEQADV 9D90 CYS C 501 UNP Q2N0S5 ALA 498 ENGINEERED MUTATION SEQADV 9D90 PRO D 559 UNP Q2N0S5 ILE 556 ENGINEERED MUTATION SEQADV 9D90 CYS D 605 UNP Q2N0S5 THR 602 ENGINEERED MUTATION SEQADV 9D90 PRO E 559 UNP Q2N0S5 ILE 556 ENGINEERED MUTATION SEQADV 9D90 CYS E 605 UNP Q2N0S5 THR 602 ENGINEERED MUTATION SEQADV 9D90 PRO F 559 UNP Q2N0S5 ILE 556 ENGINEERED MUTATION SEQADV 9D90 CYS F 605 UNP Q2N0S5 THR 602 ENGINEERED MUTATION SEQRES 1 A 469 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 A 469 LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 A 469 LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR SEQRES 4 A 469 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 A 469 HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET TRP LYS SEQRES 6 A 469 ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE ILE SER SEQRES 7 A 469 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 A 469 PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL THR ASN SEQRES 9 A 469 ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS ASN CYS SEQRES 10 A 469 SER PHE ASN MET THR THR GLU LEU ARG ASP LYS LYS GLN SEQRES 11 A 469 LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL VAL GLN SEQRES 12 A 469 ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SER ASN SEQRES 13 A 469 LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER ALA ILE SEQRES 14 A 469 THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO ILE PRO SEQRES 15 A 469 ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE LEU LYS SEQRES 16 A 469 CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO CYS PRO SEQRES 17 A 469 SER VAL SER THR VAL GLN CYS THR HIS GLY ILE LYS PRO SEQRES 18 A 469 VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA SEQRES 19 A 469 GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE THR ASN SEQRES 20 A 469 ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR PRO VAL SEQRES 21 A 469 GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR ARG LYS SEQRES 22 A 469 SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR ALA THR SEQRES 23 A 469 GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS CYS ASN SEQRES 24 A 469 VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY LYS VAL SEQRES 25 A 469 VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN THR ILE SEQRES 26 A 469 ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU GLU VAL SEQRES 27 A 469 THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE PHE TYR SEQRES 28 A 469 CYS ASN THR SER GLY LEU PHE ASN SER THR TRP ILE SER SEQRES 29 A 469 ASN THR SER VAL GLN GLY SER ASN SER THR GLY SER ASN SEQRES 30 A 469 ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN ILE ILE SEQRES 31 A 469 ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR ALA PRO SEQRES 32 A 469 PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN ILE THR SEQRES 33 A 469 GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR ASN SER SEQRES 34 A 469 THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP MET ARG SEQRES 35 A 469 ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL SEQRES 36 A 469 LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS LYS SEQRES 37 A 469 ARG SEQRES 1 B 469 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 B 469 LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 B 469 LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR SEQRES 4 B 469 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 B 469 HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET TRP LYS SEQRES 6 B 469 ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE ILE SER SEQRES 7 B 469 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 B 469 PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL THR ASN SEQRES 9 B 469 ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS ASN CYS SEQRES 10 B 469 SER PHE ASN MET THR THR GLU LEU ARG ASP LYS LYS GLN SEQRES 11 B 469 LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL VAL GLN SEQRES 12 B 469 ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SER ASN SEQRES 13 B 469 LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER ALA ILE SEQRES 14 B 469 THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO ILE PRO SEQRES 15 B 469 ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE LEU LYS SEQRES 16 B 469 CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO CYS PRO SEQRES 17 B 469 SER VAL SER THR VAL GLN CYS THR HIS GLY ILE LYS PRO SEQRES 18 B 469 VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA SEQRES 19 B 469 GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE THR ASN SEQRES 20 B 469 ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR PRO VAL SEQRES 21 B 469 GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR ARG LYS SEQRES 22 B 469 SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR ALA THR SEQRES 23 B 469 GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS CYS ASN SEQRES 24 B 469 VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY LYS VAL SEQRES 25 B 469 VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN THR ILE SEQRES 26 B 469 ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU GLU VAL SEQRES 27 B 469 THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE PHE TYR SEQRES 28 B 469 CYS ASN THR SER GLY LEU PHE ASN SER THR TRP ILE SER SEQRES 29 B 469 ASN THR SER VAL GLN GLY SER ASN SER THR GLY SER ASN SEQRES 30 B 469 ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN ILE ILE SEQRES 31 B 469 ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR ALA PRO SEQRES 32 B 469 PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN ILE THR SEQRES 33 B 469 GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR ASN SER SEQRES 34 B 469 THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP MET ARG SEQRES 35 B 469 ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL SEQRES 36 B 469 LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS LYS SEQRES 37 B 469 ARG SEQRES 1 C 469 ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP SEQRES 2 C 469 LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA SEQRES 3 C 469 LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR SEQRES 4 C 469 HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE SEQRES 5 C 469 HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET TRP LYS SEQRES 6 C 469 ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE ILE SER SEQRES 7 C 469 LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR SEQRES 8 C 469 PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL THR ASN SEQRES 9 C 469 ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS ASN CYS SEQRES 10 C 469 SER PHE ASN MET THR THR GLU LEU ARG ASP LYS LYS GLN SEQRES 11 C 469 LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL VAL GLN SEQRES 12 C 469 ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SER ASN SEQRES 13 C 469 LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER ALA ILE SEQRES 14 C 469 THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO ILE PRO SEQRES 15 C 469 ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE LEU LYS SEQRES 16 C 469 CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO CYS PRO SEQRES 17 C 469 SER VAL SER THR VAL GLN CYS THR HIS GLY ILE LYS PRO SEQRES 18 C 469 VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA SEQRES 19 C 469 GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE THR ASN SEQRES 20 C 469 ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR PRO VAL SEQRES 21 C 469 GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR ARG LYS SEQRES 22 C 469 SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR ALA THR SEQRES 23 C 469 GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS CYS ASN SEQRES 24 C 469 VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY LYS VAL SEQRES 25 C 469 VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN THR ILE SEQRES 26 C 469 ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU GLU VAL SEQRES 27 C 469 THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE PHE TYR SEQRES 28 C 469 CYS ASN THR SER GLY LEU PHE ASN SER THR TRP ILE SER SEQRES 29 C 469 ASN THR SER VAL GLN GLY SER ASN SER THR GLY SER ASN SEQRES 30 C 469 ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN ILE ILE SEQRES 31 C 469 ASN MET TRP GLN ARG ILE GLY GLN ALA MET TYR ALA PRO SEQRES 32 C 469 PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN ILE THR SEQRES 33 C 469 GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR ASN SER SEQRES 34 C 469 THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP MET ARG SEQRES 35 C 469 ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL SEQRES 36 C 469 LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG CYS LYS SEQRES 37 C 469 ARG SEQRES 1 D 149 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 D 149 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 D 149 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 D 149 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 D 149 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 D 149 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 D 149 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 D 149 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 D 149 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 D 149 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 D 149 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 D 149 LYS ASN GLU GLN ASP LEU SEQRES 1 E 149 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 E 149 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 E 149 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 E 149 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 E 149 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 E 149 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 E 149 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 E 149 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 E 149 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 E 149 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 E 149 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 E 149 LYS ASN GLU GLN ASP LEU SEQRES 1 F 149 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 F 149 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 F 149 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 F 149 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 F 149 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 F 149 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 F 149 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 F 149 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 F 149 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 F 149 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 F 149 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 F 149 LYS ASN GLU GLN ASP LEU SEQRES 1 G 223 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 G 223 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 G 223 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 G 223 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 G 223 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 G 223 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 G 223 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 G 223 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 G 223 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 G 223 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 G 223 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 G 223 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 G 223 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 G 223 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 G 223 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 G 223 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 G 223 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 G 223 PRO LYS SEQRES 1 H 212 ASP ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SEQRES 2 H 212 SER VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER SEQRES 3 H 212 GLN GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS SEQRES 4 H 212 PRO GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER SEQRES 5 H 212 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR SEQRES 6 H 212 GLY SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU SEQRES 7 H 212 GLN PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SEQRES 8 H 212 SER SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 H 212 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 H 212 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 H 212 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 H 212 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 H 212 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 H 212 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 H 212 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 H 212 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 H 212 PHE ASN ARG GLY SEQRES 1 I 223 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 I 223 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 I 223 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 I 223 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 I 223 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 I 223 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 I 223 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 I 223 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 I 223 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 I 223 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 I 223 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 I 223 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 I 223 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 I 223 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 I 223 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 I 223 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 I 223 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 I 223 PRO LYS SEQRES 1 J 212 ASP ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SEQRES 2 J 212 SER VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER SEQRES 3 J 212 GLN GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS SEQRES 4 J 212 PRO GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER SEQRES 5 J 212 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR SEQRES 6 J 212 GLY SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU SEQRES 7 J 212 GLN PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SEQRES 8 J 212 SER SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 J 212 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 J 212 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 J 212 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 J 212 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 J 212 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 J 212 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 J 212 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 J 212 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 J 212 PHE ASN ARG GLY SEQRES 1 K 223 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 K 223 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 K 223 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 K 223 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 K 223 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 K 223 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 K 223 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 K 223 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 K 223 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 K 223 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 K 223 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 K 223 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 K 223 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 K 223 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 K 223 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 K 223 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 K 223 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 K 223 PRO LYS SEQRES 1 L 212 ASP ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SEQRES 2 L 212 SER VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 212 GLN GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS SEQRES 4 L 212 PRO GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER SEQRES 5 L 212 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR SEQRES 6 L 212 GLY SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU SEQRES 7 L 212 GLN PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SEQRES 8 L 212 SER SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 L 212 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 L 212 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 L 212 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 L 212 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 L 212 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 L 212 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 L 212 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 L 212 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 L 212 PHE ASN ARG GLY SEQRES 1 M 181 LYS LYS VAL VAL LEU GLY LYS LYS GLY ASP THR VAL GLU SEQRES 2 M 181 LEU THR CYS THR ALA SER GLN LYS LYS SER ILE GLN PHE SEQRES 3 M 181 HIS TRP LYS ASN SER ASN GLN ILE LYS ILE LEU GLY ASN SEQRES 4 M 181 GLN GLY SER PHE LEU THR LYS GLY PRO SER LYS LEU ASN SEQRES 5 M 181 ASP ARG ALA ASP SER ARG ARG SER LEU TRP ASP GLN GLY SEQRES 6 M 181 ASN PHE PRO LEU ILE ILE LYS ASN LEU LYS ILE GLU ASP SEQRES 7 M 181 SER ASP THR TYR ILE CYS GLU VAL GLU ASP GLN LYS GLU SEQRES 8 M 181 GLU VAL GLN LEU LEU VAL PHE GLY LEU THR ALA ASN SER SEQRES 9 M 181 ASP THR HIS LEU LEU GLN GLY GLN SER LEU THR LEU THR SEQRES 10 M 181 LEU GLU SER PRO PRO GLY SER SER PRO SER VAL GLN CYS SEQRES 11 M 181 ARG SER PRO ARG GLY LYS ASN ILE GLN GLY GLY LYS THR SEQRES 12 M 181 LEU SER VAL SER GLN LEU GLU LEU GLN ASP SER GLY THR SEQRES 13 M 181 TRP THR CYS THR VAL LEU GLN ASN GLN LYS LYS VAL GLU SEQRES 14 M 181 PHE LYS ILE ASP ILE VAL VAL LEU ALA PHE GLN LYS SEQRES 1 N 181 LYS LYS VAL VAL LEU GLY LYS LYS GLY ASP THR VAL GLU SEQRES 2 N 181 LEU THR CYS THR ALA SER GLN LYS LYS SER ILE GLN PHE SEQRES 3 N 181 HIS TRP LYS ASN SER ASN GLN ILE LYS ILE LEU GLY ASN SEQRES 4 N 181 GLN GLY SER PHE LEU THR LYS GLY PRO SER LYS LEU ASN SEQRES 5 N 181 ASP ARG ALA ASP SER ARG ARG SER LEU TRP ASP GLN GLY SEQRES 6 N 181 ASN PHE PRO LEU ILE ILE LYS ASN LEU LYS ILE GLU ASP SEQRES 7 N 181 SER ASP THR TYR ILE CYS GLU VAL GLU ASP GLN LYS GLU SEQRES 8 N 181 GLU VAL GLN LEU LEU VAL PHE GLY LEU THR ALA ASN SER SEQRES 9 N 181 ASP THR HIS LEU LEU GLN GLY GLN SER LEU THR LEU THR SEQRES 10 N 181 LEU GLU SER PRO PRO GLY SER SER PRO SER VAL GLN CYS SEQRES 11 N 181 ARG SER PRO ARG GLY LYS ASN ILE GLN GLY GLY LYS THR SEQRES 12 N 181 LEU SER VAL SER GLN LEU GLU LEU GLN ASP SER GLY THR SEQRES 13 N 181 TRP THR CYS THR VAL LEU GLN ASN GLN LYS LYS VAL GLU SEQRES 14 N 181 PHE LYS ILE ASP ILE VAL VAL LEU ALA PHE GLN LYS SEQRES 1 O 181 LYS LYS VAL VAL LEU GLY LYS LYS GLY ASP THR VAL GLU SEQRES 2 O 181 LEU THR CYS THR ALA SER GLN LYS LYS SER ILE GLN PHE SEQRES 3 O 181 HIS TRP LYS ASN SER ASN GLN ILE LYS ILE LEU GLY ASN SEQRES 4 O 181 GLN GLY SER PHE LEU THR LYS GLY PRO SER LYS LEU ASN SEQRES 5 O 181 ASP ARG ALA ASP SER ARG ARG SER LEU TRP ASP GLN GLY SEQRES 6 O 181 ASN PHE PRO LEU ILE ILE LYS ASN LEU LYS ILE GLU ASP SEQRES 7 O 181 SER ASP THR TYR ILE CYS GLU VAL GLU ASP GLN LYS GLU SEQRES 8 O 181 GLU VAL GLN LEU LEU VAL PHE GLY LEU THR ALA ASN SER SEQRES 9 O 181 ASP THR HIS LEU LEU GLN GLY GLN SER LEU THR LEU THR SEQRES 10 O 181 LEU GLU SER PRO PRO GLY SER SER PRO SER VAL GLN CYS SEQRES 11 O 181 ARG SER PRO ARG GLY LYS ASN ILE GLN GLY GLY LYS THR SEQRES 12 O 181 LEU SER VAL SER GLN LEU GLU LEU GLN ASP SER GLY THR SEQRES 13 O 181 TRP THR CYS THR VAL LEU GLN ASN GLN LYS LYS VAL GLU SEQRES 14 O 181 PHE LYS ILE ASP ILE VAL VAL LEU ALA PHE GLN LYS SEQRES 1 P 214 ASP ILE VAL MET THR GLN SER PRO ALA THR LEU SER VAL SEQRES 2 P 214 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 P 214 GLU SER VAL SER SER ASP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 P 214 PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SER SEQRES 5 P 214 THR ARG ALA THR GLY VAL PRO ALA ARG PHE SER GLY SER SEQRES 6 P 214 GLY SER GLY ALA GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 P 214 GLN SER GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN TYR SEQRES 8 P 214 ASN ASN TRP PRO PRO ARG TYR THR PHE GLY GLN GLY THR SEQRES 9 P 214 ARG LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 10 P 214 PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY SEQRES 11 P 214 THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO SEQRES 12 P 214 ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU SEQRES 13 P 214 GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SEQRES 14 P 214 SER LYS ASP SER THR TYR SER LEU SER SER THR LEU THR SEQRES 15 P 214 LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA SEQRES 16 P 214 CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR SEQRES 17 P 214 LYS SER PHE ASN ARG GLY SEQRES 1 Q 229 GLU VAL GLN LEU VAL GLU SER GLY ALA GLU VAL LYS LYS SEQRES 2 Q 229 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 Q 229 ASP THR PHE ILE ARG TYR SER PHE THR TRP VAL ARG GLN SEQRES 4 Q 229 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY ARG ILE ILE SEQRES 5 Q 229 THR ILE LEU ASP VAL ALA HIS TYR ALA PRO HIS LEU GLN SEQRES 6 Q 229 GLY ARG VAL THR ILE THR ALA ASP LYS SER THR SER THR SEQRES 7 Q 229 VAL TYR LEU GLU LEU ARG ASN LEU ARG SER ASP ASP THR SEQRES 8 Q 229 ALA VAL TYR PHE CYS ALA GLY VAL TYR GLU GLY GLU ALA SEQRES 9 Q 229 ASP GLU GLY GLU TYR ASP ASN ASN GLY PHE LEU LYS HIS SEQRES 10 Q 229 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 Q 229 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 Q 229 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 Q 229 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 Q 229 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 Q 229 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 Q 229 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 Q 229 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 Q 229 VAL ASP LYS LYS VAL GLU PRO LYS SEQRES 1 R 214 ASP ILE VAL MET THR GLN SER PRO ALA THR LEU SER VAL SEQRES 2 R 214 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 R 214 GLU SER VAL SER SER ASP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 R 214 PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SER SEQRES 5 R 214 THR ARG ALA THR GLY VAL PRO ALA ARG PHE SER GLY SER SEQRES 6 R 214 GLY SER GLY ALA GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 R 214 GLN SER GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN TYR SEQRES 8 R 214 ASN ASN TRP PRO PRO ARG TYR THR PHE GLY GLN GLY THR SEQRES 9 R 214 ARG LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 10 R 214 PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY SEQRES 11 R 214 THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO SEQRES 12 R 214 ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU SEQRES 13 R 214 GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SEQRES 14 R 214 SER LYS ASP SER THR TYR SER LEU SER SER THR LEU THR SEQRES 15 R 214 LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA SEQRES 16 R 214 CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR SEQRES 17 R 214 LYS SER PHE ASN ARG GLY SEQRES 1 S 229 GLU VAL GLN LEU VAL GLU SER GLY ALA GLU VAL LYS LYS SEQRES 2 S 229 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 S 229 ASP THR PHE ILE ARG TYR SER PHE THR TRP VAL ARG GLN SEQRES 4 S 229 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY ARG ILE ILE SEQRES 5 S 229 THR ILE LEU ASP VAL ALA HIS TYR ALA PRO HIS LEU GLN SEQRES 6 S 229 GLY ARG VAL THR ILE THR ALA ASP LYS SER THR SER THR SEQRES 7 S 229 VAL TYR LEU GLU LEU ARG ASN LEU ARG SER ASP ASP THR SEQRES 8 S 229 ALA VAL TYR PHE CYS ALA GLY VAL TYR GLU GLY GLU ALA SEQRES 9 S 229 ASP GLU GLY GLU TYR ASP ASN ASN GLY PHE LEU LYS HIS SEQRES 10 S 229 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 S 229 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 S 229 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 S 229 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 S 229 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 S 229 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 S 229 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 S 229 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 S 229 VAL ASP LYS LYS VAL GLU PRO LYS SEQRES 1 T 214 ASP ILE VAL MET THR GLN SER PRO ALA THR LEU SER VAL SEQRES 2 T 214 SER PRO GLY GLU ARG ALA THR LEU SER CYS ARG ALA SER SEQRES 3 T 214 GLU SER VAL SER SER ASP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 T 214 PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR GLY ALA SER SEQRES 5 T 214 THR ARG ALA THR GLY VAL PRO ALA ARG PHE SER GLY SER SEQRES 6 T 214 GLY SER GLY ALA GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 T 214 GLN SER GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN TYR SEQRES 8 T 214 ASN ASN TRP PRO PRO ARG TYR THR PHE GLY GLN GLY THR SEQRES 9 T 214 ARG LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 10 T 214 PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY SEQRES 11 T 214 THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO SEQRES 12 T 214 ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU SEQRES 13 T 214 GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SEQRES 14 T 214 SER LYS ASP SER THR TYR SER LEU SER SER THR LEU THR SEQRES 15 T 214 LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA SEQRES 16 T 214 CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR SEQRES 17 T 214 LYS SER PHE ASN ARG GLY SEQRES 1 U 229 GLU VAL GLN LEU VAL GLU SER GLY ALA GLU VAL LYS LYS SEQRES 2 U 229 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 U 229 ASP THR PHE ILE ARG TYR SER PHE THR TRP VAL ARG GLN SEQRES 4 U 229 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY ARG ILE ILE SEQRES 5 U 229 THR ILE LEU ASP VAL ALA HIS TYR ALA PRO HIS LEU GLN SEQRES 6 U 229 GLY ARG VAL THR ILE THR ALA ASP LYS SER THR SER THR SEQRES 7 U 229 VAL TYR LEU GLU LEU ARG ASN LEU ARG SER ASP ASP THR SEQRES 8 U 229 ALA VAL TYR PHE CYS ALA GLY VAL TYR GLU GLY GLU ALA SEQRES 9 U 229 ASP GLU GLY GLU TYR ASP ASN ASN GLY PHE LEU LYS HIS SEQRES 10 U 229 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 U 229 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 U 229 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 U 229 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 U 229 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 U 229 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 U 229 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 U 229 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 U 229 VAL ASP LYS LYS VAL GLU PRO LYS HET NAG V 1 14 HET NAG V 2 14 HET BMA V 3 11 HET MAN V 4 11 HET MAN V 5 11 HET NAG a 1 14 HET NAG a 2 14 HET BMA a 3 11 HET MAN a 4 11 HET MAN a 5 11 HET NAG f 1 14 HET NAG f 2 14 HET BMA f 3 11 HET MAN f 4 11 HET MAN f 5 11 HET NAG D 701 14 HET NAG E 701 14 HET NAG F 701 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 22 NAG 9(C8 H15 N O6) FORMUL 22 BMA 3(C6 H12 O6) FORMUL 22 MAN 6(C6 H12 O6) HELIX 1 AA1 HIS A 66 CYS A 74 1 9 HELIX 2 AA2 ASN A 99 LEU A 116 1 18 HELIX 3 AA3 LYS A 335 ARG A 350 1 16 HELIX 4 AA4 ASP A 368 THR A 373 1 6 HELIX 5 AA5 HIS B 66 CYS B 74 1 9 HELIX 6 AA6 ASN B 99 LEU B 116 1 18 HELIX 7 AA7 LYS B 335 ARG B 350 1 16 HELIX 8 AA8 MET B 475 ARG B 480 1 6 HELIX 9 AA9 HIS C 66 THR C 71 1 6 HELIX 10 AB1 MET C 100 LEU C 116 1 17 HELIX 11 AB2 LYS C 335 ARG C 350 1 16 HELIX 12 AB3 ASP C 368 THR C 373 1 6 HELIX 13 AB4 ARG C 476 SER C 481 1 6 HELIX 14 AB5 LEU D 537 ARG D 542 1 6 HELIX 15 AB6 LEU D 565 THR D 569 5 5 HELIX 16 AB7 ILE D 573 TRP D 596 1 24 HELIX 17 AB8 ASN D 618 ASN D 625 1 8 HELIX 18 AB9 THR D 627 ILE D 635 1 9 HELIX 19 AC1 TYR D 638 GLU D 648 1 11 HELIX 20 AC2 GLN D 650 ASP D 659 1 10 HELIX 21 AC3 THR E 529 SER E 534 1 6 HELIX 22 AC4 ALA E 541 LEU E 545 5 5 HELIX 23 AC5 LYS E 567 GLY E 572 1 6 HELIX 24 AC6 GLY E 572 GLY E 597 1 26 HELIX 25 AC7 ASN E 618 ASN E 625 1 8 HELIX 26 AC8 THR E 627 SER E 636 1 10 HELIX 27 AC9 TYR E 638 GLN E 652 1 15 HELIX 28 AD1 THR F 529 SER F 534 1 6 HELIX 29 AD2 THR F 536 ASN F 543 1 8 HELIX 30 AD3 LEU F 566 TRP F 596 1 31 HELIX 31 AD4 ASN F 618 ASN F 625 1 8 HELIX 32 AD5 THR F 627 SER F 636 1 10 HELIX 33 AD6 TYR F 638 SER F 649 1 12 HELIX 34 AD7 GLN F 650 GLN F 653 5 4 HELIX 35 AD8 THR G 83 THR G 87 5 5 HELIX 36 AD9 THR I 28 ASN I 32 5 5 HELIX 37 AE1 THR I 83 THR I 87 5 5 HELIX 38 AE2 GLN J 79 PHE J 83 5 5 HELIX 39 AE3 THR K 28 ASN K 32 5 5 HELIX 40 AE4 THR K 83 THR K 87 5 5 HELIX 41 AE5 GLN L 79 PHE L 83 5 5 HELIX 42 AE6 ARG M 59 GLN M 64 5 6 HELIX 43 AE7 LYS M 75 SER M 79 5 5 HELIX 44 AE8 ARG N 58 TRP N 62 5 5 HELIX 45 AE9 LYS N 75 SER N 79 5 5 HELIX 46 AF1 LYS O 75 SER O 79 5 5 HELIX 47 AF2 THR Q 28 ILE Q 30 5 3 HELIX 48 AF3 ARG Q 83 THR Q 87 5 5 HELIX 49 AF4 GLN R 79 PHE R 83 5 5 HELIX 50 AF5 THR S 28 ILE S 30 5 3 HELIX 51 AF6 ARG S 83 THR S 87 5 5 HELIX 52 AF7 THR U 28 ILE U 30 5 3 HELIX 53 AF8 ARG U 83 THR U 87 5 5 HELIX 54 AF9 GLU U 99 GLY U 100C 5 5 SHEET 1 AA1 2 TRP A 35 TYR A 40 0 SHEET 2 AA1 2 LEU A 494 THR A 499 -1 O THR A 499 N TRP A 35 SHEET 1 AA2 5 TRP A 45 ASP A 47 0 SHEET 2 AA2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AA2 5 PHE A 223 CYS A 228 -1 N LEU A 226 O LYS A 487 SHEET 4 AA2 5 VAL A 242 VAL A 245 -1 O SER A 243 N LYS A 227 SHEET 5 AA2 5 GLU A 83 HIS A 85 -1 N ILE A 84 O THR A 244 SHEET 1 AA3 2 PHE A 53 ALA A 55 0 SHEET 2 AA3 2 HIS A 216 CYS A 218 -1 O CYS A 218 N PHE A 53 SHEET 1 AA4 2 GLU A 91 PHE A 93 0 SHEET 2 AA4 2 GLY A 237 CYS A 239 -1 O CYS A 239 N GLU A 91 SHEET 1 AA5 3 LYS A 121 LEU A 122 0 SHEET 2 AA5 3 GLN A 432 MET A 434 -1 O GLN A 432 N LEU A 122 SHEET 3 AA5 3 ILE A 423 ASN A 425 -1 N ILE A 424 O ALA A 433 SHEET 1 AA6 6 LEU A 260 LEU A 261 0 SHEET 2 AA6 6 VAL A 446 ASP A 457 -1 O THR A 450 N LEU A 260 SHEET 3 AA6 6 ILE A 284 THR A 297 -1 N VAL A 292 O ILE A 449 SHEET 4 AA6 6 GLU A 466 PRO A 470 0 SHEET 5 AA6 6 ILE A 359 PHE A 361 1 N ARG A 360 O PHE A 468 SHEET 6 AA6 6 THR A 394 TRP A 395 -1 O TRP A 395 N ILE A 359 SHEET 1 AA7 5 MET A 271 ARG A 273 0 SHEET 2 AA7 5 ILE A 284 THR A 297 -1 O LEU A 285 N ARG A 273 SHEET 3 AA7 5 VAL A 446 ASP A 457 -1 O ILE A 449 N VAL A 292 SHEET 4 AA7 5 HIS A 330 SER A 334 0 SHEET 5 AA7 5 SER A 413 THR A 415 -1 O ILE A 414 N VAL A 333 SHEET 1 AA8 3 HIS A 374 CYS A 378 0 SHEET 2 AA8 3 GLU A 381 CYS A 385 -1 O PHE A 383 N PHE A 376 SHEET 3 AA8 3 CYS A 418 ARG A 419 -1 O ARG A 419 N TYR A 384 SHEET 1 AA9 3 LEU B 494 THR B 499 0 SHEET 2 AA9 3 TRP B 35 TYR B 40 -1 N TRP B 35 O THR B 499 SHEET 3 AA9 3 ILE E 603 PRO E 609 -1 O CYS E 604 N VAL B 38 SHEET 1 AB1 5 TRP B 45 ASP B 47 0 SHEET 2 AB1 5 TYR B 486 ILE B 491 -1 O LYS B 490 N LYS B 46 SHEET 3 AB1 5 PHE B 223 CYS B 228 -1 N ALA B 224 O VAL B 489 SHEET 4 AB1 5 VAL B 242 VAL B 245 -1 O VAL B 245 N ILE B 225 SHEET 5 AB1 5 GLU B 83 HIS B 85 -1 N ILE B 84 O THR B 244 SHEET 1 AB2 2 GLU B 91 GLU B 92 0 SHEET 2 AB2 2 PRO B 238 CYS B 239 -1 O CYS B 239 N GLU B 91 SHEET 1 AB3 4 ILE B 201 THR B 202 0 SHEET 2 AB3 4 VAL B 120 LEU B 122 -1 N LYS B 121 O ILE B 201 SHEET 3 AB3 4 GLN B 432 MET B 434 -1 O GLN B 432 N LEU B 122 SHEET 4 AB3 4 ILE B 423 ASN B 425 -1 N ILE B 424 O ALA B 433 SHEET 1 AB4 6 LEU B 260 LEU B 261 0 SHEET 2 AB4 6 ILE B 443 ARG B 456 -1 O GLY B 451 N LEU B 260 SHEET 3 AB4 6 ILE B 284 ARG B 298 -1 N VAL B 292 O ILE B 449 SHEET 4 AB4 6 GLU B 466 PRO B 470 0 SHEET 5 AB4 6 ILE B 359 PHE B 361 1 N ARG B 360 O PHE B 468 SHEET 6 AB4 6 THR B 394 TRP B 395 -1 O TRP B 395 N ILE B 359 SHEET 1 AB5 5 MET B 271 ARG B 273 0 SHEET 2 AB5 5 ILE B 284 ARG B 298 -1 O LEU B 285 N ARG B 273 SHEET 3 AB5 5 ILE B 443 ARG B 456 -1 O ILE B 449 N VAL B 292 SHEET 4 AB5 5 HIS B 330 SER B 334 0 SHEET 5 AB5 5 SER B 413 ILE B 414 -1 O ILE B 414 N VAL B 333 SHEET 1 AB6 3 HIS B 374 CYS B 378 0 SHEET 2 AB6 3 GLU B 381 CYS B 385 -1 O CYS B 385 N HIS B 374 SHEET 3 AB6 3 ARG B 419 ILE B 420 -1 O ARG B 419 N TYR B 384 SHEET 1 AB7 3 LEU C 494 THR C 499 0 SHEET 2 AB7 3 TRP C 35 TYR C 40 -1 N THR C 37 O ALA C 497 SHEET 3 AB7 3 ILE F 603 PRO F 609 -1 O THR F 606 N VAL C 36 SHEET 1 AB8 5 TRP C 45 ASP C 47 0 SHEET 2 AB8 5 TYR C 486 ILE C 491 -1 O LYS C 490 N LYS C 46 SHEET 3 AB8 5 PHE C 223 CYS C 228 -1 N ALA C 224 O VAL C 489 SHEET 4 AB8 5 VAL C 242 VAL C 245 -1 O VAL C 245 N ILE C 225 SHEET 5 AB8 5 GLU C 83 HIS C 85 -1 N ILE C 84 O THR C 244 SHEET 1 AB9 2 GLU C 91 PHE C 93 0 SHEET 2 AB9 2 GLY C 237 CYS C 239 -1 O CYS C 239 N GLU C 91 SHEET 1 AC1 4 THR C 198 THR C 202 0 SHEET 2 AC1 4 VAL C 120 PRO C 124 -1 N THR C 123 O SER C 199 SHEET 3 AC1 4 GLN C 432 MET C 434 -1 O MET C 434 N VAL C 120 SHEET 4 AC1 4 ILE C 423 ASN C 425 -1 N ILE C 424 O ALA C 433 SHEET 1 AC2 6 LEU C 260 LEU C 261 0 SHEET 2 AC2 6 VAL C 446 ASP C 457 -1 O GLY C 451 N LEU C 260 SHEET 3 AC2 6 ILE C 284 THR C 297 -1 N VAL C 292 O ILE C 449 SHEET 4 AC2 6 GLU C 466 ARG C 469 0 SHEET 5 AC2 6 ILE C 359 ARG C 360 1 N ARG C 360 O PHE C 468 SHEET 6 AC2 6 THR C 394 TRP C 395 -1 O TRP C 395 N ILE C 359 SHEET 1 AC3 5 MET C 271 ARG C 273 0 SHEET 2 AC3 5 ILE C 284 THR C 297 -1 O LEU C 285 N ARG C 273 SHEET 3 AC3 5 VAL C 446 ASP C 457 -1 O ILE C 449 N VAL C 292 SHEET 4 AC3 5 HIS C 330 SER C 334 0 SHEET 5 AC3 5 SER C 413 ILE C 414 -1 O ILE C 414 N VAL C 333 SHEET 1 AC4 2 HIS C 374 ASN C 377 0 SHEET 2 AC4 2 PHE C 382 CYS C 385 -1 O CYS C 385 N HIS C 374 SHEET 1 AC5 4 VAL G 3 GLN G 6 0 SHEET 2 AC5 4 SER G 17 PHE G 25 -1 O ARG G 23 N VAL G 5 SHEET 3 AC5 4 THR G 77 THR G 82A-1 O VAL G 82 N VAL G 18 SHEET 4 AC5 4 VAL G 67 ASP G 72 -1 N TYR G 68 O ASP G 81 SHEET 1 AC6 6 GLU G 10 VAL G 11 0 SHEET 2 AC6 6 THR G 107 THR G 110 1 O SER G 108 N GLU G 10 SHEET 3 AC6 6 GLY G 88 ASP G 95 -1 N GLY G 88 O VAL G 109 SHEET 4 AC6 6 LEU G 34 GLN G 39 -1 N VAL G 37 O TYR G 91 SHEET 5 AC6 6 LEU G 45 ILE G 51 -1 O GLU G 46 N ARG G 38 SHEET 6 AC6 6 THR G 57 THR G 59 -1 O THR G 58 N TRP G 50 SHEET 1 AC7 4 GLU G 10 VAL G 11 0 SHEET 2 AC7 4 THR G 107 THR G 110 1 O SER G 108 N GLU G 10 SHEET 3 AC7 4 GLY G 88 ASP G 95 -1 N GLY G 88 O VAL G 109 SHEET 4 AC7 4 MET G 100E TRP G 103 -1 O VAL G 102 N ARG G 94 SHEET 1 AC8 4 THR H 5 SER H 7 0 SHEET 2 AC8 4 VAL H 19 ARG H 24 -1 O THR H 22 N SER H 7 SHEET 3 AC8 4 HIS H 70 VAL H 75 -1 O PHE H 71 N CYS H 23 SHEET 4 AC8 4 PHE H 62 SER H 67 -1 N THR H 65 O THR H 72 SHEET 1 AC9 6 PHE H 10 SER H 12 0 SHEET 2 AC9 6 THR H 102 GLU H 105 1 O LYS H 103 N LEU H 11 SHEET 3 AC9 6 THR H 85 HIS H 90 -1 N TYR H 86 O THR H 102 SHEET 4 AC9 6 LEU H 33 GLN H 38 -1 N GLN H 38 O THR H 85 SHEET 5 AC9 6 ASN H 45 TYR H 49 -1 O LEU H 47 N TRP H 35 SHEET 6 AC9 6 THR H 53 LEU H 54 -1 O THR H 53 N TYR H 49 SHEET 1 AD1 4 VAL I 3 GLN I 6 0 SHEET 2 AD1 4 SER I 17 PHE I 25 -1 O PHE I 25 N VAL I 3 SHEET 3 AD1 4 THR I 77 THR I 82A-1 O LEU I 80 N VAL I 20 SHEET 4 AD1 4 VAL I 67 ASP I 72 -1 N TYR I 68 O ASP I 81 SHEET 1 AD2 6 GLU I 10 VAL I 11 0 SHEET 2 AD2 6 THR I 107 THR I 110 1 O SER I 108 N GLU I 10 SHEET 3 AD2 6 GLY I 88 ASP I 95 -1 N GLY I 88 O VAL I 109 SHEET 4 AD2 6 LEU I 34 GLN I 39 -1 N GLN I 39 O ILE I 89 SHEET 5 AD2 6 LEU I 45 ILE I 51 -1 O GLU I 46 N ARG I 38 SHEET 6 AD2 6 THR I 57 THR I 59 -1 O THR I 58 N TRP I 50 SHEET 1 AD3 4 GLU I 10 VAL I 11 0 SHEET 2 AD3 4 THR I 107 THR I 110 1 O SER I 108 N GLU I 10 SHEET 3 AD3 4 GLY I 88 ASP I 95 -1 N GLY I 88 O VAL I 109 SHEET 4 AD3 4 MET I 100E TRP I 103 -1 O VAL I 102 N ARG I 94 SHEET 1 AD4 4 LEU J 4 SER J 7 0 SHEET 2 AD4 4 VAL J 19 ALA J 25 -1 O THR J 22 N SER J 7 SHEET 3 AD4 4 HIS J 70 VAL J 75 -1 O LEU J 73 N ILE J 21 SHEET 4 AD4 4 PHE J 62 SER J 67 -1 N THR J 65 O THR J 72 SHEET 1 AD5 6 PHE J 10 SER J 12 0 SHEET 2 AD5 6 THR J 102 GLU J 105 1 O GLU J 105 N LEU J 11 SHEET 3 AD5 6 THR J 85 HIS J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AD5 6 LEU J 33 GLN J 38 -1 N TYR J 36 O PHE J 87 SHEET 5 AD5 6 ASN J 45 TYR J 49 -1 O LEU J 47 N TRP J 35 SHEET 6 AD5 6 THR J 53 LEU J 54 -1 O THR J 53 N TYR J 49 SHEET 1 AD6 4 VAL K 3 GLN K 6 0 SHEET 2 AD6 4 SER K 17 PHE K 25 -1 O ARG K 23 N VAL K 5 SHEET 3 AD6 4 THR K 77 THR K 82A-1 O ALA K 78 N CYS K 22 SHEET 4 AD6 4 VAL K 67 ASP K 72 -1 N TYR K 68 O ASP K 81 SHEET 1 AD7 6 GLU K 10 VAL K 11 0 SHEET 2 AD7 6 THR K 107 THR K 110 1 O SER K 108 N GLU K 10 SHEET 3 AD7 6 GLY K 88 ASP K 95 -1 N GLY K 88 O VAL K 109 SHEET 4 AD7 6 LEU K 34 GLN K 39 -1 N HIS K 35 O ALA K 93 SHEET 5 AD7 6 GLU K 46 ILE K 51 -1 O ILE K 51 N LEU K 34 SHEET 6 AD7 6 THR K 57 THR K 59 -1 O THR K 58 N TRP K 50 SHEET 1 AD8 4 GLU K 10 VAL K 11 0 SHEET 2 AD8 4 THR K 107 THR K 110 1 O SER K 108 N GLU K 10 SHEET 3 AD8 4 GLY K 88 ASP K 95 -1 N GLY K 88 O VAL K 109 SHEET 4 AD8 4 MET K 100E TRP K 103 -1 O VAL K 102 N ARG K 94 SHEET 1 AD9 4 LEU L 4 SER L 7 0 SHEET 2 AD9 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AD9 4 HIS L 70 VAL L 75 -1 O PHE L 71 N CYS L 23 SHEET 4 AD9 4 PHE L 62 SER L 67 -1 N THR L 65 O THR L 72 SHEET 1 AE1 2 PHE L 10 SER L 12 0 SHEET 2 AE1 2 LYS L 103 GLU L 105 1 O LYS L 103 N LEU L 11 SHEET 1 AE2 4 THR L 53 LEU L 54 0 SHEET 2 AE2 4 PRO L 44 TYR L 49 -1 N TYR L 49 O THR L 53 SHEET 3 AE2 4 LEU L 33 GLN L 38 -1 N GLN L 37 O ASN L 45 SHEET 4 AE2 4 THR L 85 HIS L 90 -1 O THR L 85 N GLN L 38 SHEET 1 AE3 6 LYS M 2 VAL M 4 0 SHEET 2 AE3 6 GLN M 89 LEU M 95 1 O GLN M 94 N LYS M 2 SHEET 3 AE3 6 THR M 81 VAL M 86 -1 N TYR M 82 O VAL M 93 SHEET 4 AE3 6 HIS M 27 LYS M 29 -1 N LYS M 29 O ILE M 83 SHEET 5 AE3 6 LYS M 35 GLY M 38 -1 O ILE M 36 N TRP M 28 SHEET 6 AE3 6 THR M 45 LYS M 46 -1 O THR M 45 N GLY M 38 SHEET 1 AE4 3 VAL M 12 LEU M 14 0 SHEET 2 AE4 3 LEU M 69 ILE M 71 -1 O ILE M 71 N VAL M 12 SHEET 3 AE4 3 ALA M 55 ASP M 56 -1 N ASP M 56 O ILE M 70 SHEET 1 AE5 6 LYS N 2 LEU N 5 0 SHEET 2 AE5 6 GLN N 89 LEU N 96 1 O GLN N 94 N LYS N 2 SHEET 3 AE5 6 THR N 81 VAL N 86 -1 N TYR N 82 O VAL N 93 SHEET 4 AE5 6 PHE N 26 LYS N 29 -1 N LYS N 29 O ILE N 83 SHEET 5 AE5 6 LYS N 35 ASN N 39 -1 O ILE N 36 N TRP N 28 SHEET 6 AE5 6 LEU N 44 LYS N 46 -1 O THR N 45 N GLY N 38 SHEET 1 AE6 3 VAL N 12 LEU N 14 0 SHEET 2 AE6 3 LEU N 69 ILE N 71 -1 O LEU N 69 N LEU N 14 SHEET 3 AE6 3 ALA N 55 ASP N 56 -1 N ASP N 56 O ILE N 70 SHEET 1 AE7 6 LYS O 2 LEU O 5 0 SHEET 2 AE7 6 GLN O 89 LEU O 96 1 O GLN O 94 N VAL O 4 SHEET 3 AE7 6 THR O 81 VAL O 86 -1 N CYS O 84 O GLU O 91 SHEET 4 AE7 6 HIS O 27 LYS O 29 -1 N LYS O 29 O ILE O 83 SHEET 5 AE7 6 LYS O 35 GLN O 40 -1 O ILE O 36 N TRP O 28 SHEET 6 AE7 6 PHE O 43 LYS O 46 -1 O THR O 45 N GLY O 38 SHEET 1 AE8 3 VAL O 12 LEU O 14 0 SHEET 2 AE8 3 LEU O 69 ILE O 71 -1 O LEU O 69 N LEU O 14 SHEET 3 AE8 3 ALA O 55 ASP O 56 -1 N ASP O 56 O ILE O 70 SHEET 1 AE9 2 MET P 4 THR P 5 0 SHEET 2 AE9 2 ARG P 24 ALA P 25 -1 O ARG P 24 N THR P 5 SHEET 1 AF1 3 ALA P 19 LEU P 21 0 SHEET 2 AF1 3 GLU P 70 ILE P 75 -1 O LEU P 73 N LEU P 21 SHEET 3 AF1 3 PHE P 62 SER P 67 -1 N SER P 65 O THR P 72 SHEET 1 AF2 5 THR P 53 ARG P 54 0 SHEET 2 AF2 5 ARG P 45 TYR P 49 -1 N TYR P 49 O THR P 53 SHEET 3 AF2 5 ALA P 34 GLN P 38 -1 N TRP P 35 O ILE P 48 SHEET 4 AF2 5 ALA P 84 GLN P 89 -1 O VAL P 85 N GLN P 38 SHEET 5 AF2 5 THR P 102 LEU P 104 -1 O LEU P 104 N ALA P 84 SHEET 1 AF3 4 GLN Q 3 GLU Q 6 0 SHEET 2 AF3 4 SER Q 17 SER Q 25 -1 O LYS Q 23 N VAL Q 5 SHEET 3 AF3 4 THR Q 77 ARG Q 82A-1 O LEU Q 80 N VAL Q 20 SHEET 4 AF3 4 VAL Q 67 ASP Q 72 -1 N ASP Q 72 O THR Q 77 SHEET 1 AF4 6 GLU Q 10 VAL Q 11 0 SHEET 2 AF4 6 THR Q 107 THR Q 110 1 O LEU Q 108 N GLU Q 10 SHEET 3 AF4 6 ALA Q 88 TYR Q 96 -1 N ALA Q 88 O VAL Q 109 SHEET 4 AF4 6 TYR Q 32 GLN Q 39 -1 N SER Q 33 O VAL Q 95 SHEET 5 AF4 6 LEU Q 45 ILE Q 52 -1 O ILE Q 51 N PHE Q 34 SHEET 6 AF4 6 VAL Q 56 TYR Q 59 -1 O HIS Q 58 N ARG Q 50 SHEET 1 AF5 4 GLU Q 10 VAL Q 11 0 SHEET 2 AF5 4 THR Q 107 THR Q 110 1 O LEU Q 108 N GLU Q 10 SHEET 3 AF5 4 ALA Q 88 TYR Q 96 -1 N ALA Q 88 O VAL Q 109 SHEET 4 AF5 4 HIS Q 102 TRP Q 103 -1 O HIS Q 102 N GLY Q 94 SHEET 1 AF6 3 ALA R 19 ARG R 24 0 SHEET 2 AF6 3 GLU R 70 ILE R 75 -1 O LEU R 73 N LEU R 21 SHEET 3 AF6 3 PHE R 62 SER R 67 -1 N SER R 63 O THR R 74 SHEET 1 AF7 5 THR R 53 ARG R 54 0 SHEET 2 AF7 5 ARG R 45 TYR R 49 -1 N TYR R 49 O THR R 53 SHEET 3 AF7 5 LEU R 33 GLN R 38 -1 N GLN R 37 O ARG R 45 SHEET 4 AF7 5 VAL R 85 GLN R 90 -1 O TYR R 87 N TYR R 36 SHEET 5 AF7 5 THR R 102 ARG R 103 -1 O THR R 102 N TYR R 86 SHEET 1 AF8 4 GLN S 3 GLU S 6 0 SHEET 2 AF8 4 SER S 17 SER S 25 -1 O LYS S 23 N VAL S 5 SHEET 3 AF8 4 THR S 77 ARG S 82A-1 O LEU S 80 N VAL S 20 SHEET 4 AF8 4 VAL S 67 ASP S 72 -1 N THR S 70 O TYR S 79 SHEET 1 AF9 6 GLU S 10 VAL S 11 0 SHEET 2 AF9 6 THR S 107 THR S 110 1 O LEU S 108 N GLU S 10 SHEET 3 AF9 6 ALA S 88 TYR S 96 -1 N ALA S 88 O VAL S 109 SHEET 4 AF9 6 TYR S 32 GLN S 39 -1 N VAL S 37 O PHE S 91 SHEET 5 AF9 6 LEU S 45 ILE S 52 -1 O GLU S 46 N ARG S 38 SHEET 6 AF9 6 VAL S 56 TYR S 59 -1 O HIS S 58 N ARG S 50 SHEET 1 AG1 4 GLU S 10 VAL S 11 0 SHEET 2 AG1 4 THR S 107 THR S 110 1 O LEU S 108 N GLU S 10 SHEET 3 AG1 4 ALA S 88 TYR S 96 -1 N ALA S 88 O VAL S 109 SHEET 4 AG1 4 HIS S 102 TRP S 103 -1 O HIS S 102 N GLY S 94 SHEET 1 AG2 4 MET T 4 GLN T 6 0 SHEET 2 AG2 4 ALA T 19 ALA T 25 -1 O ARG T 24 N THR T 5 SHEET 3 AG2 4 GLU T 70 ILE T 75 -1 O PHE T 71 N CYS T 23 SHEET 4 AG2 4 PHE T 62 SER T 67 -1 N SER T 65 O THR T 72 SHEET 1 AG3 4 ARG T 45 LEU T 46 0 SHEET 2 AG3 4 LEU T 33 GLN T 38 -1 N GLN T 37 O ARG T 45 SHEET 3 AG3 4 VAL T 85 GLN T 90 -1 O TYR T 87 N TYR T 36 SHEET 4 AG3 4 THR T 102 ARG T 103 -1 O THR T 102 N TYR T 86 SHEET 1 AG4 2 ILE T 48 TYR T 49 0 SHEET 2 AG4 2 THR T 53 ARG T 54 -1 O THR T 53 N TYR T 49 SHEET 1 AG5 4 GLN U 3 GLU U 6 0 SHEET 2 AG5 4 SER U 17 SER U 25 -1 O LYS U 23 N VAL U 5 SHEET 3 AG5 4 THR U 77 ARG U 82A-1 O LEU U 80 N VAL U 20 SHEET 4 AG5 4 VAL U 67 ASP U 72 -1 N THR U 70 O TYR U 79 SHEET 1 AG6 6 GLU U 10 VAL U 11 0 SHEET 2 AG6 6 THR U 107 THR U 110 1 O THR U 110 N GLU U 10 SHEET 3 AG6 6 ALA U 88 TYR U 96 -1 N TYR U 90 O THR U 107 SHEET 4 AG6 6 TYR U 32 GLN U 39 -1 N GLN U 39 O VAL U 89 SHEET 5 AG6 6 LEU U 45 ILE U 52 -1 O GLU U 46 N ARG U 38 SHEET 6 AG6 6 VAL U 56 HIS U 58 -1 O VAL U 56 N ILE U 52 SHEET 1 AG7 4 GLU U 10 VAL U 11 0 SHEET 2 AG7 4 THR U 107 THR U 110 1 O THR U 110 N GLU U 10 SHEET 3 AG7 4 ALA U 88 TYR U 96 -1 N TYR U 90 O THR U 107 SHEET 4 AG7 4 HIS U 102 TRP U 103 -1 O HIS U 102 N GLY U 94 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.03 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.03 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.04 SSBOND 4 CYS A 218 CYS A 247 1555 1555 2.03 SSBOND 5 CYS A 228 CYS A 239 1555 1555 2.03 SSBOND 6 CYS A 296 CYS A 331 1555 1555 2.04 SSBOND 7 CYS A 378 CYS A 445 1555 1555 2.03 SSBOND 8 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 9 CYS A 501 CYS D 605 1555 1555 2.03 SSBOND 10 CYS B 54 CYS B 74 1555 1555 2.03 SSBOND 11 CYS B 119 CYS B 205 1555 1555 2.03 SSBOND 12 CYS B 126 CYS B 196 1555 1555 2.04 SSBOND 13 CYS B 218 CYS B 247 1555 1555 2.06 SSBOND 14 CYS B 228 CYS B 239 1555 1555 2.03 SSBOND 15 CYS B 296 CYS B 331 1555 1555 2.04 SSBOND 16 CYS B 378 CYS B 445 1555 1555 2.04 SSBOND 17 CYS B 385 CYS B 418 1555 1555 2.03 SSBOND 18 CYS B 501 CYS E 605 1555 1555 2.03 SSBOND 19 CYS C 54 CYS C 74 1555 1555 2.02 SSBOND 20 CYS C 119 CYS C 205 1555 1555 2.03 SSBOND 21 CYS C 126 CYS C 196 1555 1555 2.03 SSBOND 22 CYS C 218 CYS C 247 1555 1555 2.05 SSBOND 23 CYS C 228 CYS C 239 1555 1555 2.03 SSBOND 24 CYS C 296 CYS C 331 1555 1555 2.03 SSBOND 25 CYS C 378 CYS C 445 1555 1555 2.03 SSBOND 26 CYS C 385 CYS C 418 1555 1555 2.03 SSBOND 27 CYS C 501 CYS F 605 1555 1555 2.03 SSBOND 28 CYS D 598 CYS D 604 1555 1555 2.03 SSBOND 29 CYS E 598 CYS E 604 1555 1555 2.03 SSBOND 30 CYS F 598 CYS F 604 1555 1555 2.03 SSBOND 31 CYS G 22 CYS G 92 1555 1555 2.03 SSBOND 32 CYS H 23 CYS H 88 1555 1555 2.04 SSBOND 33 CYS I 22 CYS I 92 1555 1555 2.03 SSBOND 34 CYS J 23 CYS J 88 1555 1555 2.04 SSBOND 35 CYS K 22 CYS K 92 1555 1555 2.04 SSBOND 36 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 37 CYS M 16 CYS M 84 1555 1555 2.03 SSBOND 38 CYS N 16 CYS N 84 1555 1555 2.03 SSBOND 39 CYS O 16 CYS O 84 1555 1555 2.03 SSBOND 40 CYS P 23 CYS P 88 1555 1555 2.03 SSBOND 41 CYS Q 22 CYS Q 92 1555 1555 2.04 SSBOND 42 CYS R 23 CYS R 88 1555 1555 2.04 SSBOND 43 CYS S 22 CYS S 92 1555 1555 2.03 SSBOND 44 CYS T 23 CYS T 88 1555 1555 2.04 SSBOND 45 CYS U 22 CYS U 92 1555 1555 2.03 LINK ND2 ASN A 88 C1 NAG V 1 1555 1555 1.43 LINK ND2 ASN B 88 C1 NAG a 1 1555 1555 1.46 LINK ND2 ASN C 88 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN D 611 C1 NAG D 701 1555 1555 1.44 LINK ND2 ASN E 611 C1 NAG E 701 1555 1555 1.44 LINK ND2 ASN F 611 C1 NAG F 701 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG V 2 C1 BMA V 3 1555 1555 1.48 LINK O3 BMA V 3 C1 MAN V 4 1555 1555 1.45 LINK O6 BMA V 3 C1 MAN V 5 1555 1555 1.45 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.44 LINK O4 NAG a 2 C1 BMA a 3 1555 1555 1.46 LINK O3 BMA a 3 C1 MAN a 4 1555 1555 1.45 LINK O6 BMA a 3 C1 MAN a 5 1555 1555 1.44 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.45 LINK O4 NAG f 2 C1 BMA f 3 1555 1555 1.47 LINK O3 BMA f 3 C1 MAN f 4 1555 1555 1.44 LINK O6 BMA f 3 C1 MAN f 5 1555 1555 1.44 CISPEP 1 SER H 7 PRO H 8 0 -4.21 CISPEP 2 TYR H 94 PRO H 95 0 -9.00 CISPEP 3 SER J 7 PRO J 8 0 -6.10 CISPEP 4 TYR J 94 PRO J 95 0 -10.73 CISPEP 5 SER L 7 PRO L 8 0 -10.29 CISPEP 6 TYR L 94 PRO L 95 0 -9.55 CISPEP 7 TRP P 94 PRO P 95 0 3.60 CISPEP 8 TRP R 94 PRO R 95 0 2.92 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000