HEADER VIRAL PROTEIN 27-AUG-24 9DD6 TITLE CRYO-EM STRUCTURE OF NEUTRALIZING MURINE ANTIBODY WS.HSV-1.24 IN TITLE 2 COMPLEX WITH HSV-1 GLYCOPROTEIN B TRIMER GB-ECTO.516P.531E COMPND MOL_ID: 1; COMPND 2 MOLECULE: GLYCOPROTEIN B; COMPND 3 CHAIN: E, F, G; COMPND 4 FRAGMENT: HSV-1 GB ECTODOMAIN; COMPND 5 ENGINEERED: YES; COMPND 6 MUTATION: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: WS.HSV-1.24 HEAVY CHAIN; COMPND 9 CHAIN: H, I, J; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: WS.HSV-1.24 LIGHT CHAIN; COMPND 13 CHAIN: L, M, N; COMPND 14 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN ALPHAHERPESVIRUS 1; SOURCE 3 ORGANISM_COMMON: HERPES SIMPLEX VIRUS TYPE 1; SOURCE 4 ORGANISM_TAXID: 10298; SOURCE 5 GENE: UL27, HHV1GP041; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 10 ORGANISM_TAXID: 10090; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 15 ORGANISM_TAXID: 10090; SOURCE 16 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS IMMUNE COMPLEX, NEUTRALIZATION, HERPES FUSOGEN, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR R.S.ROARK,L.S.SHAPIRO,P.D.KWONG REVDAT 1 10-SEP-25 9DD6 0 JRNL AUTH R.S.ROARK,L.SHAPIRO,P.D.KWONG JRNL TITL PREFUSION STRUCTURE AND NEUTRALIZATION OF HSV-1 GLYCOPROTEIN JRNL TITL 2 B JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.10 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.100 REMARK 3 NUMBER OF PARTICLES : 127859 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9DD6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-AUG-24. REMARK 100 THE DEPOSITION ID IS D_1000287876. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : WS.HSV-1.24 FAB IN COMPLEX WITH REMARK 245 HSV-1 GB TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5800.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, G, H, I, J, L, M, N, A, REMARK 350 AND CHAINS: B, C, D, K, O REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET E 1 REMARK 465 HIS E 2 REMARK 465 GLN E 3 REMARK 465 GLY E 4 REMARK 465 ALA E 5 REMARK 465 PRO E 6 REMARK 465 SER E 7 REMARK 465 TRP E 8 REMARK 465 GLY E 9 REMARK 465 ARG E 10 REMARK 465 ARG E 11 REMARK 465 TRP E 12 REMARK 465 PHE E 13 REMARK 465 VAL E 14 REMARK 465 VAL E 15 REMARK 465 TRP E 16 REMARK 465 ALA E 17 REMARK 465 LEU E 18 REMARK 465 LEU E 19 REMARK 465 GLY E 20 REMARK 465 LEU E 21 REMARK 465 THR E 22 REMARK 465 LEU E 23 REMARK 465 GLY E 24 REMARK 465 VAL E 25 REMARK 465 LEU E 26 REMARK 465 VAL E 27 REMARK 465 ALA E 28 REMARK 465 SER E 29 REMARK 465 ALA E 30 REMARK 465 ALA E 31 REMARK 465 PRO E 32 REMARK 465 SER E 33 REMARK 465 SER E 34 REMARK 465 PRO E 35 REMARK 465 GLY E 36 REMARK 465 THR E 37 REMARK 465 PRO E 38 REMARK 465 GLY E 39 REMARK 465 VAL E 40 REMARK 465 ALA E 41 REMARK 465 ALA E 42 REMARK 465 ALA E 43 REMARK 465 THR E 44 REMARK 465 GLN E 45 REMARK 465 ALA E 46 REMARK 465 ALA E 47 REMARK 465 ASN E 48 REMARK 465 GLY E 49 REMARK 465 GLY E 50 REMARK 465 PRO E 51 REMARK 465 ALA E 52 REMARK 465 THR E 53 REMARK 465 PRO E 54 REMARK 465 ALA E 55 REMARK 465 PRO E 56 REMARK 465 PRO E 57 REMARK 465 ALA E 58 REMARK 465 LEU E 59 REMARK 465 GLY E 60 REMARK 465 ALA E 61 REMARK 465 ALA E 62 REMARK 465 PRO E 63 REMARK 465 THR E 64 REMARK 465 GLY E 65 REMARK 465 ASP E 66 REMARK 465 PRO E 67 REMARK 465 LYS E 68 REMARK 465 PRO E 69 REMARK 465 LYS E 70 REMARK 465 LYS E 71 REMARK 465 ASN E 72 REMARK 465 LYS E 73 REMARK 465 LYS E 74 REMARK 465 PRO E 75 REMARK 465 LYS E 76 REMARK 465 ASN E 77 REMARK 465 PRO E 78 REMARK 465 THR E 79 REMARK 465 PRO E 80 REMARK 465 PRO E 81 REMARK 465 ARG E 82 REMARK 465 PRO E 83 REMARK 465 ALA E 84 REMARK 465 GLY E 85 REMARK 465 ASP E 86 REMARK 465 ASN E 87 REMARK 465 ALA E 88 REMARK 465 THR E 89 REMARK 465 VAL E 90 REMARK 465 ALA E 91 REMARK 465 ALA E 92 REMARK 465 GLY E 93 REMARK 465 HIS E 94 REMARK 465 ALA E 95 REMARK 465 THR E 96 REMARK 465 LEU E 97 REMARK 465 ARG E 98 REMARK 465 GLU E 99 REMARK 465 HIS E 100 REMARK 465 LEU E 101 REMARK 465 ARG E 102 REMARK 465 ASP E 103 REMARK 465 ILE E 104 REMARK 465 LYS E 105 REMARK 465 ALA E 106 REMARK 465 GLU E 107 REMARK 465 ASN E 108 REMARK 465 TRP E 174 REMARK 465 PHE E 175 REMARK 465 GLY E 176 REMARK 465 HIS E 177 REMARK 465 ARG E 178 REMARK 465 TYR E 179 REMARK 465 SER E 180 REMARK 465 GLN E 181 REMARK 465 PHE E 182 REMARK 465 MET E 183 REMARK 465 GLY E 184 REMARK 465 LEU E 252 REMARK 465 LYS E 253 REMARK 465 TYR E 254 REMARK 465 ASN E 255 REMARK 465 PRO E 256 REMARK 465 SER E 257 REMARK 465 ARG E 258 REMARK 465 VAL E 259 REMARK 465 GLU E 260 REMARK 465 ALA E 261 REMARK 465 PHE E 262 REMARK 465 HIS E 263 REMARK 465 ARG E 264 REMARK 465 TYR E 265 REMARK 465 GLY E 266 REMARK 465 ARG E 474 REMARK 465 LYS E 475 REMARK 465 PRO E 476 REMARK 465 PRO E 477 REMARK 465 ASN E 478 REMARK 465 PRO E 479 REMARK 465 THR E 480 REMARK 465 PRO E 481 REMARK 465 PRO E 482 REMARK 465 PRO E 483 REMARK 465 PRO E 484 REMARK 465 GLY E 485 REMARK 465 ALA E 486 REMARK 465 SER E 487 REMARK 465 ALA E 488 REMARK 465 ASN E 489 REMARK 465 ALA E 490 REMARK 465 SER E 491 REMARK 465 VAL E 492 REMARK 465 GLU E 493 REMARK 465 ARG E 494 REMARK 465 ILE E 495 REMARK 465 LYS E 496 REMARK 465 THR E 497 REMARK 465 THR E 498 REMARK 465 SER E 499 REMARK 465 SER E 500 REMARK 465 VAL E 722 REMARK 465 ILE E 723 REMARK 465 HIS E 724 REMARK 465 ALA E 725 REMARK 465 ASP E 726 REMARK 465 ALA E 727 REMARK 465 ASN E 728 REMARK 465 GLY E 729 REMARK 465 SER E 730 REMARK 465 GLY E 731 REMARK 465 TYR E 732 REMARK 465 ILE E 733 REMARK 465 PRO E 734 REMARK 465 GLU E 735 REMARK 465 ALA E 736 REMARK 465 PRO E 737 REMARK 465 ARG E 738 REMARK 465 ASP E 739 REMARK 465 GLY E 740 REMARK 465 GLN E 741 REMARK 465 ALA E 742 REMARK 465 TYR E 743 REMARK 465 VAL E 744 REMARK 465 ARG E 745 REMARK 465 LYS E 746 REMARK 465 ASP E 747 REMARK 465 GLY E 748 REMARK 465 GLU E 749 REMARK 465 TRP E 750 REMARK 465 VAL E 751 REMARK 465 LEU E 752 REMARK 465 LEU E 753 REMARK 465 SER E 754 REMARK 465 THR E 755 REMARK 465 PHE E 756 REMARK 465 LEU E 757 REMARK 465 GLY E 758 REMARK 465 ARG E 759 REMARK 465 SER E 760 REMARK 465 LEU E 761 REMARK 465 GLU E 762 REMARK 465 VAL E 763 REMARK 465 LEU E 764 REMARK 465 PHE E 765 REMARK 465 GLN E 766 REMARK 465 GLY E 767 REMARK 465 PRO E 768 REMARK 465 GLY E 769 REMARK 465 HIS E 770 REMARK 465 HIS E 771 REMARK 465 HIS E 772 REMARK 465 HIS E 773 REMARK 465 HIS E 774 REMARK 465 HIS E 775 REMARK 465 HIS E 776 REMARK 465 HIS E 777 REMARK 465 SER E 778 REMARK 465 ALA E 779 REMARK 465 TRP E 780 REMARK 465 SER E 781 REMARK 465 HIS E 782 REMARK 465 PRO E 783 REMARK 465 GLN E 784 REMARK 465 PHE E 785 REMARK 465 GLU E 786 REMARK 465 LYS E 787 REMARK 465 GLY E 788 REMARK 465 GLY E 789 REMARK 465 GLY E 790 REMARK 465 SER E 791 REMARK 465 GLY E 792 REMARK 465 GLY E 793 REMARK 465 GLY E 794 REMARK 465 GLY E 795 REMARK 465 SER E 796 REMARK 465 GLY E 797 REMARK 465 GLY E 798 REMARK 465 SER E 799 REMARK 465 ALA E 800 REMARK 465 TRP E 801 REMARK 465 SER E 802 REMARK 465 HIS E 803 REMARK 465 PRO E 804 REMARK 465 GLN E 805 REMARK 465 PHE E 806 REMARK 465 GLU E 807 REMARK 465 LYS E 808 REMARK 465 MET F 1 REMARK 465 HIS F 2 REMARK 465 GLN F 3 REMARK 465 GLY F 4 REMARK 465 ALA F 5 REMARK 465 PRO F 6 REMARK 465 SER F 7 REMARK 465 TRP F 8 REMARK 465 GLY F 9 REMARK 465 ARG F 10 REMARK 465 ARG F 11 REMARK 465 TRP F 12 REMARK 465 PHE F 13 REMARK 465 VAL F 14 REMARK 465 VAL F 15 REMARK 465 TRP F 16 REMARK 465 ALA F 17 REMARK 465 LEU F 18 REMARK 465 LEU F 19 REMARK 465 GLY F 20 REMARK 465 LEU F 21 REMARK 465 THR F 22 REMARK 465 LEU F 23 REMARK 465 GLY F 24 REMARK 465 VAL F 25 REMARK 465 LEU F 26 REMARK 465 VAL F 27 REMARK 465 ALA F 28 REMARK 465 SER F 29 REMARK 465 ALA F 30 REMARK 465 ALA F 31 REMARK 465 PRO F 32 REMARK 465 SER F 33 REMARK 465 SER F 34 REMARK 465 PRO F 35 REMARK 465 GLY F 36 REMARK 465 THR F 37 REMARK 465 PRO F 38 REMARK 465 GLY F 39 REMARK 465 VAL F 40 REMARK 465 ALA F 41 REMARK 465 ALA F 42 REMARK 465 ALA F 43 REMARK 465 THR F 44 REMARK 465 GLN F 45 REMARK 465 ALA F 46 REMARK 465 ALA F 47 REMARK 465 ASN F 48 REMARK 465 GLY F 49 REMARK 465 GLY F 50 REMARK 465 PRO F 51 REMARK 465 ALA F 52 REMARK 465 THR F 53 REMARK 465 PRO F 54 REMARK 465 ALA F 55 REMARK 465 PRO F 56 REMARK 465 PRO F 57 REMARK 465 ALA F 58 REMARK 465 LEU F 59 REMARK 465 GLY F 60 REMARK 465 ALA F 61 REMARK 465 ALA F 62 REMARK 465 PRO F 63 REMARK 465 THR F 64 REMARK 465 GLY F 65 REMARK 465 ASP F 66 REMARK 465 PRO F 67 REMARK 465 LYS F 68 REMARK 465 PRO F 69 REMARK 465 LYS F 70 REMARK 465 LYS F 71 REMARK 465 ASN F 72 REMARK 465 LYS F 73 REMARK 465 LYS F 74 REMARK 465 PRO F 75 REMARK 465 LYS F 76 REMARK 465 ASN F 77 REMARK 465 PRO F 78 REMARK 465 THR F 79 REMARK 465 PRO F 80 REMARK 465 PRO F 81 REMARK 465 ARG F 82 REMARK 465 PRO F 83 REMARK 465 ALA F 84 REMARK 465 GLY F 85 REMARK 465 ASP F 86 REMARK 465 ASN F 87 REMARK 465 ALA F 88 REMARK 465 THR F 89 REMARK 465 VAL F 90 REMARK 465 ALA F 91 REMARK 465 ALA F 92 REMARK 465 GLY F 93 REMARK 465 HIS F 94 REMARK 465 ALA F 95 REMARK 465 THR F 96 REMARK 465 LEU F 97 REMARK 465 ARG F 98 REMARK 465 GLU F 99 REMARK 465 HIS F 100 REMARK 465 LEU F 101 REMARK 465 ARG F 102 REMARK 465 ASP F 103 REMARK 465 ILE F 104 REMARK 465 LYS F 105 REMARK 465 ALA F 106 REMARK 465 GLU F 107 REMARK 465 ASN F 108 REMARK 465 TRP F 174 REMARK 465 PHE F 175 REMARK 465 GLY F 176 REMARK 465 HIS F 177 REMARK 465 ARG F 178 REMARK 465 TYR F 179 REMARK 465 SER F 180 REMARK 465 GLN F 181 REMARK 465 PHE F 182 REMARK 465 MET F 183 REMARK 465 GLY F 184 REMARK 465 LEU F 252 REMARK 465 LYS F 253 REMARK 465 TYR F 254 REMARK 465 ASN F 255 REMARK 465 PRO F 256 REMARK 465 SER F 257 REMARK 465 ARG F 258 REMARK 465 VAL F 259 REMARK 465 GLU F 260 REMARK 465 ALA F 261 REMARK 465 PHE F 262 REMARK 465 HIS F 263 REMARK 465 ARG F 264 REMARK 465 TYR F 265 REMARK 465 GLY F 266 REMARK 465 ARG F 474 REMARK 465 LYS F 475 REMARK 465 PRO F 476 REMARK 465 PRO F 477 REMARK 465 ASN F 478 REMARK 465 PRO F 479 REMARK 465 THR F 480 REMARK 465 PRO F 481 REMARK 465 PRO F 482 REMARK 465 PRO F 483 REMARK 465 PRO F 484 REMARK 465 GLY F 485 REMARK 465 ALA F 486 REMARK 465 SER F 487 REMARK 465 ALA F 488 REMARK 465 ASN F 489 REMARK 465 ALA F 490 REMARK 465 SER F 491 REMARK 465 VAL F 492 REMARK 465 GLU F 493 REMARK 465 ARG F 494 REMARK 465 ILE F 495 REMARK 465 LYS F 496 REMARK 465 THR F 497 REMARK 465 THR F 498 REMARK 465 SER F 499 REMARK 465 SER F 500 REMARK 465 VAL F 722 REMARK 465 ILE F 723 REMARK 465 HIS F 724 REMARK 465 ALA F 725 REMARK 465 ASP F 726 REMARK 465 ALA F 727 REMARK 465 ASN F 728 REMARK 465 GLY F 729 REMARK 465 SER F 730 REMARK 465 GLY F 731 REMARK 465 TYR F 732 REMARK 465 ILE F 733 REMARK 465 PRO F 734 REMARK 465 GLU F 735 REMARK 465 ALA F 736 REMARK 465 PRO F 737 REMARK 465 ARG F 738 REMARK 465 ASP F 739 REMARK 465 GLY F 740 REMARK 465 GLN F 741 REMARK 465 ALA F 742 REMARK 465 TYR F 743 REMARK 465 VAL F 744 REMARK 465 ARG F 745 REMARK 465 LYS F 746 REMARK 465 ASP F 747 REMARK 465 GLY F 748 REMARK 465 GLU F 749 REMARK 465 TRP F 750 REMARK 465 VAL F 751 REMARK 465 LEU F 752 REMARK 465 LEU F 753 REMARK 465 SER F 754 REMARK 465 THR F 755 REMARK 465 PHE F 756 REMARK 465 LEU F 757 REMARK 465 GLY F 758 REMARK 465 ARG F 759 REMARK 465 SER F 760 REMARK 465 LEU F 761 REMARK 465 GLU F 762 REMARK 465 VAL F 763 REMARK 465 LEU F 764 REMARK 465 PHE F 765 REMARK 465 GLN F 766 REMARK 465 GLY F 767 REMARK 465 PRO F 768 REMARK 465 GLY F 769 REMARK 465 HIS F 770 REMARK 465 HIS F 771 REMARK 465 HIS F 772 REMARK 465 HIS F 773 REMARK 465 HIS F 774 REMARK 465 HIS F 775 REMARK 465 HIS F 776 REMARK 465 HIS F 777 REMARK 465 SER F 778 REMARK 465 ALA F 779 REMARK 465 TRP F 780 REMARK 465 SER F 781 REMARK 465 HIS F 782 REMARK 465 PRO F 783 REMARK 465 GLN F 784 REMARK 465 PHE F 785 REMARK 465 GLU F 786 REMARK 465 LYS F 787 REMARK 465 GLY F 788 REMARK 465 GLY F 789 REMARK 465 GLY F 790 REMARK 465 SER F 791 REMARK 465 GLY F 792 REMARK 465 GLY F 793 REMARK 465 GLY F 794 REMARK 465 GLY F 795 REMARK 465 SER F 796 REMARK 465 GLY F 797 REMARK 465 GLY F 798 REMARK 465 SER F 799 REMARK 465 ALA F 800 REMARK 465 TRP F 801 REMARK 465 SER F 802 REMARK 465 HIS F 803 REMARK 465 PRO F 804 REMARK 465 GLN F 805 REMARK 465 PHE F 806 REMARK 465 GLU F 807 REMARK 465 LYS F 808 REMARK 465 MET G 1 REMARK 465 HIS G 2 REMARK 465 GLN G 3 REMARK 465 GLY G 4 REMARK 465 ALA G 5 REMARK 465 PRO G 6 REMARK 465 SER G 7 REMARK 465 TRP G 8 REMARK 465 GLY G 9 REMARK 465 ARG G 10 REMARK 465 ARG G 11 REMARK 465 TRP G 12 REMARK 465 PHE G 13 REMARK 465 VAL G 14 REMARK 465 VAL G 15 REMARK 465 TRP G 16 REMARK 465 ALA G 17 REMARK 465 LEU G 18 REMARK 465 LEU G 19 REMARK 465 GLY G 20 REMARK 465 LEU G 21 REMARK 465 THR G 22 REMARK 465 LEU G 23 REMARK 465 GLY G 24 REMARK 465 VAL G 25 REMARK 465 LEU G 26 REMARK 465 VAL G 27 REMARK 465 ALA G 28 REMARK 465 SER G 29 REMARK 465 ALA G 30 REMARK 465 ALA G 31 REMARK 465 PRO G 32 REMARK 465 SER G 33 REMARK 465 SER G 34 REMARK 465 PRO G 35 REMARK 465 GLY G 36 REMARK 465 THR G 37 REMARK 465 PRO G 38 REMARK 465 GLY G 39 REMARK 465 VAL G 40 REMARK 465 ALA G 41 REMARK 465 ALA G 42 REMARK 465 ALA G 43 REMARK 465 THR G 44 REMARK 465 GLN G 45 REMARK 465 ALA G 46 REMARK 465 ALA G 47 REMARK 465 ASN G 48 REMARK 465 GLY G 49 REMARK 465 GLY G 50 REMARK 465 PRO G 51 REMARK 465 ALA G 52 REMARK 465 THR G 53 REMARK 465 PRO G 54 REMARK 465 ALA G 55 REMARK 465 PRO G 56 REMARK 465 PRO G 57 REMARK 465 ALA G 58 REMARK 465 LEU G 59 REMARK 465 GLY G 60 REMARK 465 ALA G 61 REMARK 465 ALA G 62 REMARK 465 PRO G 63 REMARK 465 THR G 64 REMARK 465 GLY G 65 REMARK 465 ASP G 66 REMARK 465 PRO G 67 REMARK 465 LYS G 68 REMARK 465 PRO G 69 REMARK 465 LYS G 70 REMARK 465 LYS G 71 REMARK 465 ASN G 72 REMARK 465 LYS G 73 REMARK 465 LYS G 74 REMARK 465 PRO G 75 REMARK 465 LYS G 76 REMARK 465 ASN G 77 REMARK 465 PRO G 78 REMARK 465 THR G 79 REMARK 465 PRO G 80 REMARK 465 PRO G 81 REMARK 465 ARG G 82 REMARK 465 PRO G 83 REMARK 465 ALA G 84 REMARK 465 GLY G 85 REMARK 465 ASP G 86 REMARK 465 ASN G 87 REMARK 465 ALA G 88 REMARK 465 THR G 89 REMARK 465 VAL G 90 REMARK 465 ALA G 91 REMARK 465 ALA G 92 REMARK 465 GLY G 93 REMARK 465 HIS G 94 REMARK 465 ALA G 95 REMARK 465 THR G 96 REMARK 465 LEU G 97 REMARK 465 ARG G 98 REMARK 465 GLU G 99 REMARK 465 HIS G 100 REMARK 465 LEU G 101 REMARK 465 ARG G 102 REMARK 465 ASP G 103 REMARK 465 ILE G 104 REMARK 465 LYS G 105 REMARK 465 ALA G 106 REMARK 465 GLU G 107 REMARK 465 ASN G 108 REMARK 465 TRP G 174 REMARK 465 PHE G 175 REMARK 465 GLY G 176 REMARK 465 HIS G 177 REMARK 465 ARG G 178 REMARK 465 TYR G 179 REMARK 465 SER G 180 REMARK 465 GLN G 181 REMARK 465 PHE G 182 REMARK 465 MET G 183 REMARK 465 GLY G 184 REMARK 465 LEU G 252 REMARK 465 LYS G 253 REMARK 465 TYR G 254 REMARK 465 ASN G 255 REMARK 465 PRO G 256 REMARK 465 SER G 257 REMARK 465 ARG G 258 REMARK 465 VAL G 259 REMARK 465 GLU G 260 REMARK 465 ALA G 261 REMARK 465 PHE G 262 REMARK 465 HIS G 263 REMARK 465 ARG G 264 REMARK 465 TYR G 265 REMARK 465 GLY G 266 REMARK 465 ARG G 474 REMARK 465 LYS G 475 REMARK 465 PRO G 476 REMARK 465 PRO G 477 REMARK 465 ASN G 478 REMARK 465 PRO G 479 REMARK 465 THR G 480 REMARK 465 PRO G 481 REMARK 465 PRO G 482 REMARK 465 PRO G 483 REMARK 465 PRO G 484 REMARK 465 GLY G 485 REMARK 465 ALA G 486 REMARK 465 SER G 487 REMARK 465 ALA G 488 REMARK 465 ASN G 489 REMARK 465 ALA G 490 REMARK 465 SER G 491 REMARK 465 VAL G 492 REMARK 465 GLU G 493 REMARK 465 ARG G 494 REMARK 465 ILE G 495 REMARK 465 LYS G 496 REMARK 465 THR G 497 REMARK 465 THR G 498 REMARK 465 SER G 499 REMARK 465 SER G 500 REMARK 465 VAL G 722 REMARK 465 ILE G 723 REMARK 465 HIS G 724 REMARK 465 ALA G 725 REMARK 465 ASP G 726 REMARK 465 ALA G 727 REMARK 465 ASN G 728 REMARK 465 GLY G 729 REMARK 465 SER G 730 REMARK 465 GLY G 731 REMARK 465 TYR G 732 REMARK 465 ILE G 733 REMARK 465 PRO G 734 REMARK 465 GLU G 735 REMARK 465 ALA G 736 REMARK 465 PRO G 737 REMARK 465 ARG G 738 REMARK 465 ASP G 739 REMARK 465 GLY G 740 REMARK 465 GLN G 741 REMARK 465 ALA G 742 REMARK 465 TYR G 743 REMARK 465 VAL G 744 REMARK 465 ARG G 745 REMARK 465 LYS G 746 REMARK 465 ASP G 747 REMARK 465 GLY G 748 REMARK 465 GLU G 749 REMARK 465 TRP G 750 REMARK 465 VAL G 751 REMARK 465 LEU G 752 REMARK 465 LEU G 753 REMARK 465 SER G 754 REMARK 465 THR G 755 REMARK 465 PHE G 756 REMARK 465 LEU G 757 REMARK 465 GLY G 758 REMARK 465 ARG G 759 REMARK 465 SER G 760 REMARK 465 LEU G 761 REMARK 465 GLU G 762 REMARK 465 VAL G 763 REMARK 465 LEU G 764 REMARK 465 PHE G 765 REMARK 465 GLN G 766 REMARK 465 GLY G 767 REMARK 465 PRO G 768 REMARK 465 GLY G 769 REMARK 465 HIS G 770 REMARK 465 HIS G 771 REMARK 465 HIS G 772 REMARK 465 HIS G 773 REMARK 465 HIS G 774 REMARK 465 HIS G 775 REMARK 465 HIS G 776 REMARK 465 HIS G 777 REMARK 465 SER G 778 REMARK 465 ALA G 779 REMARK 465 TRP G 780 REMARK 465 SER G 781 REMARK 465 HIS G 782 REMARK 465 PRO G 783 REMARK 465 GLN G 784 REMARK 465 PHE G 785 REMARK 465 GLU G 786 REMARK 465 LYS G 787 REMARK 465 GLY G 788 REMARK 465 GLY G 789 REMARK 465 GLY G 790 REMARK 465 SER G 791 REMARK 465 GLY G 792 REMARK 465 GLY G 793 REMARK 465 GLY G 794 REMARK 465 GLY G 795 REMARK 465 SER G 796 REMARK 465 GLY G 797 REMARK 465 GLY G 798 REMARK 465 SER G 799 REMARK 465 ALA G 800 REMARK 465 TRP G 801 REMARK 465 SER G 802 REMARK 465 HIS G 803 REMARK 465 PRO G 804 REMARK 465 GLN G 805 REMARK 465 PHE G 806 REMARK 465 GLU G 807 REMARK 465 LYS G 808 REMARK 465 ALA H 117 REMARK 465 SER H 118 REMARK 465 THR H 119 REMARK 465 THR H 120 REMARK 465 PRO H 121 REMARK 465 PRO H 122 REMARK 465 SER H 123 REMARK 465 VAL H 124 REMARK 465 TYR H 125 REMARK 465 PRO H 126 REMARK 465 LEU H 127 REMARK 465 ALA H 128 REMARK 465 PRO H 129 REMARK 465 GLY H 130 REMARK 465 SER H 131 REMARK 465 ALA H 132 REMARK 465 ALA H 133 REMARK 465 GLN H 134 REMARK 465 THR H 135 REMARK 465 ASN H 136 REMARK 465 SER H 137 REMARK 465 MET H 138 REMARK 465 VAL H 139 REMARK 465 THR H 140 REMARK 465 LEU H 141 REMARK 465 GLY H 142 REMARK 465 CYS H 143 REMARK 465 LEU H 144 REMARK 465 VAL H 145 REMARK 465 LYS H 146 REMARK 465 GLY H 147 REMARK 465 TYR H 148 REMARK 465 PHE H 149 REMARK 465 PRO H 150 REMARK 465 GLU H 151 REMARK 465 PRO H 152 REMARK 465 VAL H 153 REMARK 465 THR H 154 REMARK 465 VAL H 155 REMARK 465 THR H 156 REMARK 465 TRP H 157 REMARK 465 ASN H 158 REMARK 465 SER H 159 REMARK 465 GLY H 160 REMARK 465 SER H 161 REMARK 465 LEU H 162 REMARK 465 SER H 163 REMARK 465 SER H 164 REMARK 465 GLY H 165 REMARK 465 VAL H 166 REMARK 465 HIS H 167 REMARK 465 THR H 168 REMARK 465 PHE H 169 REMARK 465 PRO H 170 REMARK 465 ALA H 171 REMARK 465 VAL H 172 REMARK 465 LEU H 173 REMARK 465 GLN H 174 REMARK 465 SER H 175 REMARK 465 ASP H 176 REMARK 465 LEU H 177 REMARK 465 TYR H 178 REMARK 465 THR H 179 REMARK 465 LEU H 180 REMARK 465 SER H 181 REMARK 465 SER H 182 REMARK 465 SER H 183 REMARK 465 VAL H 184 REMARK 465 THR H 185 REMARK 465 VAL H 186 REMARK 465 PRO H 187 REMARK 465 SER H 188 REMARK 465 SER H 189 REMARK 465 THR H 190 REMARK 465 TRP H 191 REMARK 465 PRO H 192 REMARK 465 SER H 193 REMARK 465 GLU H 194 REMARK 465 THR H 195 REMARK 465 VAL H 196 REMARK 465 THR H 197 REMARK 465 CYS H 198 REMARK 465 ASN H 199 REMARK 465 VAL H 200 REMARK 465 ALA H 201 REMARK 465 HIS H 202 REMARK 465 PRO H 203 REMARK 465 ALA H 204 REMARK 465 SER H 205 REMARK 465 SER H 206 REMARK 465 THR H 207 REMARK 465 LYS H 208 REMARK 465 VAL H 209 REMARK 465 ASP H 210 REMARK 465 LYS H 211 REMARK 465 LYS H 212 REMARK 465 ILE H 213 REMARK 465 VAL H 214 REMARK 465 PRO H 215 REMARK 465 ARG H 216 REMARK 465 ASP H 217 REMARK 465 CYS H 218 REMARK 465 GLY H 219 REMARK 465 ALA I 117 REMARK 465 SER I 118 REMARK 465 THR I 119 REMARK 465 THR I 120 REMARK 465 PRO I 121 REMARK 465 PRO I 122 REMARK 465 SER I 123 REMARK 465 VAL I 124 REMARK 465 TYR I 125 REMARK 465 PRO I 126 REMARK 465 LEU I 127 REMARK 465 ALA I 128 REMARK 465 PRO I 129 REMARK 465 GLY I 130 REMARK 465 SER I 131 REMARK 465 ALA I 132 REMARK 465 ALA I 133 REMARK 465 GLN I 134 REMARK 465 THR I 135 REMARK 465 ASN I 136 REMARK 465 SER I 137 REMARK 465 MET I 138 REMARK 465 VAL I 139 REMARK 465 THR I 140 REMARK 465 LEU I 141 REMARK 465 GLY I 142 REMARK 465 CYS I 143 REMARK 465 LEU I 144 REMARK 465 VAL I 145 REMARK 465 LYS I 146 REMARK 465 GLY I 147 REMARK 465 TYR I 148 REMARK 465 PHE I 149 REMARK 465 PRO I 150 REMARK 465 GLU I 151 REMARK 465 PRO I 152 REMARK 465 VAL I 153 REMARK 465 THR I 154 REMARK 465 VAL I 155 REMARK 465 THR I 156 REMARK 465 TRP I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLY I 160 REMARK 465 SER I 161 REMARK 465 LEU I 162 REMARK 465 SER I 163 REMARK 465 SER I 164 REMARK 465 GLY I 165 REMARK 465 VAL I 166 REMARK 465 HIS I 167 REMARK 465 THR I 168 REMARK 465 PHE I 169 REMARK 465 PRO I 170 REMARK 465 ALA I 171 REMARK 465 VAL I 172 REMARK 465 LEU I 173 REMARK 465 GLN I 174 REMARK 465 SER I 175 REMARK 465 ASP I 176 REMARK 465 LEU I 177 REMARK 465 TYR I 178 REMARK 465 THR I 179 REMARK 465 LEU I 180 REMARK 465 SER I 181 REMARK 465 SER I 182 REMARK 465 SER I 183 REMARK 465 VAL I 184 REMARK 465 THR I 185 REMARK 465 VAL I 186 REMARK 465 PRO I 187 REMARK 465 SER I 188 REMARK 465 SER I 189 REMARK 465 THR I 190 REMARK 465 TRP I 191 REMARK 465 PRO I 192 REMARK 465 SER I 193 REMARK 465 GLU I 194 REMARK 465 THR I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 CYS I 198 REMARK 465 ASN I 199 REMARK 465 VAL I 200 REMARK 465 ALA I 201 REMARK 465 HIS I 202 REMARK 465 PRO I 203 REMARK 465 ALA I 204 REMARK 465 SER I 205 REMARK 465 SER I 206 REMARK 465 THR I 207 REMARK 465 LYS I 208 REMARK 465 VAL I 209 REMARK 465 ASP I 210 REMARK 465 LYS I 211 REMARK 465 LYS I 212 REMARK 465 ILE I 213 REMARK 465 VAL I 214 REMARK 465 PRO I 215 REMARK 465 ARG I 216 REMARK 465 ASP I 217 REMARK 465 CYS I 218 REMARK 465 GLY I 219 REMARK 465 ALA J 117 REMARK 465 SER J 118 REMARK 465 THR J 119 REMARK 465 THR J 120 REMARK 465 PRO J 121 REMARK 465 PRO J 122 REMARK 465 SER J 123 REMARK 465 VAL J 124 REMARK 465 TYR J 125 REMARK 465 PRO J 126 REMARK 465 LEU J 127 REMARK 465 ALA J 128 REMARK 465 PRO J 129 REMARK 465 GLY J 130 REMARK 465 SER J 131 REMARK 465 ALA J 132 REMARK 465 ALA J 133 REMARK 465 GLN J 134 REMARK 465 THR J 135 REMARK 465 ASN J 136 REMARK 465 SER J 137 REMARK 465 MET J 138 REMARK 465 VAL J 139 REMARK 465 THR J 140 REMARK 465 LEU J 141 REMARK 465 GLY J 142 REMARK 465 CYS J 143 REMARK 465 LEU J 144 REMARK 465 VAL J 145 REMARK 465 LYS J 146 REMARK 465 GLY J 147 REMARK 465 TYR J 148 REMARK 465 PHE J 149 REMARK 465 PRO J 150 REMARK 465 GLU J 151 REMARK 465 PRO J 152 REMARK 465 VAL J 153 REMARK 465 THR J 154 REMARK 465 VAL J 155 REMARK 465 THR J 156 REMARK 465 TRP J 157 REMARK 465 ASN J 158 REMARK 465 SER J 159 REMARK 465 GLY J 160 REMARK 465 SER J 161 REMARK 465 LEU J 162 REMARK 465 SER J 163 REMARK 465 SER J 164 REMARK 465 GLY J 165 REMARK 465 VAL J 166 REMARK 465 HIS J 167 REMARK 465 THR J 168 REMARK 465 PHE J 169 REMARK 465 PRO J 170 REMARK 465 ALA J 171 REMARK 465 VAL J 172 REMARK 465 LEU J 173 REMARK 465 GLN J 174 REMARK 465 SER J 175 REMARK 465 ASP J 176 REMARK 465 LEU J 177 REMARK 465 TYR J 178 REMARK 465 THR J 179 REMARK 465 LEU J 180 REMARK 465 SER J 181 REMARK 465 SER J 182 REMARK 465 SER J 183 REMARK 465 VAL J 184 REMARK 465 THR J 185 REMARK 465 VAL J 186 REMARK 465 PRO J 187 REMARK 465 SER J 188 REMARK 465 SER J 189 REMARK 465 THR J 190 REMARK 465 TRP J 191 REMARK 465 PRO J 192 REMARK 465 SER J 193 REMARK 465 GLU J 194 REMARK 465 THR J 195 REMARK 465 VAL J 196 REMARK 465 THR J 197 REMARK 465 CYS J 198 REMARK 465 ASN J 199 REMARK 465 VAL J 200 REMARK 465 ALA J 201 REMARK 465 HIS J 202 REMARK 465 PRO J 203 REMARK 465 ALA J 204 REMARK 465 SER J 205 REMARK 465 SER J 206 REMARK 465 THR J 207 REMARK 465 LYS J 208 REMARK 465 VAL J 209 REMARK 465 ASP J 210 REMARK 465 LYS J 211 REMARK 465 LYS J 212 REMARK 465 ILE J 213 REMARK 465 VAL J 214 REMARK 465 PRO J 215 REMARK 465 ARG J 216 REMARK 465 ASP J 217 REMARK 465 CYS J 218 REMARK 465 GLY J 219 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 ASP L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 THR L 114 REMARK 465 VAL L 115 REMARK 465 SER L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 SER L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 THR L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 GLY L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 PHE L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 LYS L 142 REMARK 465 ASP L 143 REMARK 465 ILE L 144 REMARK 465 ASN L 145 REMARK 465 VAL L 146 REMARK 465 LYS L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 ILE L 150 REMARK 465 ASP L 151 REMARK 465 GLY L 152 REMARK 465 SER L 153 REMARK 465 GLU L 154 REMARK 465 ARG L 155 REMARK 465 GLN L 156 REMARK 465 ASN L 157 REMARK 465 GLY L 158 REMARK 465 VAL L 159 REMARK 465 LEU L 160 REMARK 465 ASN L 161 REMARK 465 SER L 162 REMARK 465 TRP L 163 REMARK 465 THR L 164 REMARK 465 ASP L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 MET L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 THR L 182 REMARK 465 LYS L 183 REMARK 465 ASP L 184 REMARK 465 GLU L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 ARG L 188 REMARK 465 HIS L 189 REMARK 465 ASN L 190 REMARK 465 SER L 191 REMARK 465 TYR L 192 REMARK 465 THR L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 ALA L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 LYS L 199 REMARK 465 THR L 200 REMARK 465 SER L 201 REMARK 465 THR L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 ILE L 205 REMARK 465 VAL L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 ASN L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 ARG M 108 REMARK 465 THR M 109 REMARK 465 ASP M 110 REMARK 465 ALA M 111 REMARK 465 ALA M 112 REMARK 465 PRO M 113 REMARK 465 THR M 114 REMARK 465 VAL M 115 REMARK 465 SER M 116 REMARK 465 ILE M 117 REMARK 465 PHE M 118 REMARK 465 PRO M 119 REMARK 465 PRO M 120 REMARK 465 SER M 121 REMARK 465 SER M 122 REMARK 465 GLU M 123 REMARK 465 GLN M 124 REMARK 465 LEU M 125 REMARK 465 THR M 126 REMARK 465 SER M 127 REMARK 465 GLY M 128 REMARK 465 GLY M 129 REMARK 465 ALA M 130 REMARK 465 SER M 131 REMARK 465 VAL M 132 REMARK 465 VAL M 133 REMARK 465 CYS M 134 REMARK 465 PHE M 135 REMARK 465 LEU M 136 REMARK 465 ASN M 137 REMARK 465 ASN M 138 REMARK 465 PHE M 139 REMARK 465 TYR M 140 REMARK 465 PRO M 141 REMARK 465 LYS M 142 REMARK 465 ASP M 143 REMARK 465 ILE M 144 REMARK 465 ASN M 145 REMARK 465 VAL M 146 REMARK 465 LYS M 147 REMARK 465 TRP M 148 REMARK 465 LYS M 149 REMARK 465 ILE M 150 REMARK 465 ASP M 151 REMARK 465 GLY M 152 REMARK 465 SER M 153 REMARK 465 GLU M 154 REMARK 465 ARG M 155 REMARK 465 GLN M 156 REMARK 465 ASN M 157 REMARK 465 GLY M 158 REMARK 465 VAL M 159 REMARK 465 LEU M 160 REMARK 465 ASN M 161 REMARK 465 SER M 162 REMARK 465 TRP M 163 REMARK 465 THR M 164 REMARK 465 ASP M 165 REMARK 465 GLN M 166 REMARK 465 ASP M 167 REMARK 465 SER M 168 REMARK 465 LYS M 169 REMARK 465 ASP M 170 REMARK 465 SER M 171 REMARK 465 THR M 172 REMARK 465 TYR M 173 REMARK 465 SER M 174 REMARK 465 MET M 175 REMARK 465 SER M 176 REMARK 465 SER M 177 REMARK 465 THR M 178 REMARK 465 LEU M 179 REMARK 465 THR M 180 REMARK 465 LEU M 181 REMARK 465 THR M 182 REMARK 465 LYS M 183 REMARK 465 ASP M 184 REMARK 465 GLU M 185 REMARK 465 TYR M 186 REMARK 465 GLU M 187 REMARK 465 ARG M 188 REMARK 465 HIS M 189 REMARK 465 ASN M 190 REMARK 465 SER M 191 REMARK 465 TYR M 192 REMARK 465 THR M 193 REMARK 465 CYS M 194 REMARK 465 GLU M 195 REMARK 465 ALA M 196 REMARK 465 THR M 197 REMARK 465 HIS M 198 REMARK 465 LYS M 199 REMARK 465 THR M 200 REMARK 465 SER M 201 REMARK 465 THR M 202 REMARK 465 SER M 203 REMARK 465 PRO M 204 REMARK 465 ILE M 205 REMARK 465 VAL M 206 REMARK 465 LYS M 207 REMARK 465 SER M 208 REMARK 465 PHE M 209 REMARK 465 ASN M 210 REMARK 465 ARG M 211 REMARK 465 ASN M 212 REMARK 465 GLU M 213 REMARK 465 CYS M 214 REMARK 465 ARG N 108 REMARK 465 THR N 109 REMARK 465 ASP N 110 REMARK 465 ALA N 111 REMARK 465 ALA N 112 REMARK 465 PRO N 113 REMARK 465 THR N 114 REMARK 465 VAL N 115 REMARK 465 SER N 116 REMARK 465 ILE N 117 REMARK 465 PHE N 118 REMARK 465 PRO N 119 REMARK 465 PRO N 120 REMARK 465 SER N 121 REMARK 465 SER N 122 REMARK 465 GLU N 123 REMARK 465 GLN N 124 REMARK 465 LEU N 125 REMARK 465 THR N 126 REMARK 465 SER N 127 REMARK 465 GLY N 128 REMARK 465 GLY N 129 REMARK 465 ALA N 130 REMARK 465 SER N 131 REMARK 465 VAL N 132 REMARK 465 VAL N 133 REMARK 465 CYS N 134 REMARK 465 PHE N 135 REMARK 465 LEU N 136 REMARK 465 ASN N 137 REMARK 465 ASN N 138 REMARK 465 PHE N 139 REMARK 465 TYR N 140 REMARK 465 PRO N 141 REMARK 465 LYS N 142 REMARK 465 ASP N 143 REMARK 465 ILE N 144 REMARK 465 ASN N 145 REMARK 465 VAL N 146 REMARK 465 LYS N 147 REMARK 465 TRP N 148 REMARK 465 LYS N 149 REMARK 465 ILE N 150 REMARK 465 ASP N 151 REMARK 465 GLY N 152 REMARK 465 SER N 153 REMARK 465 GLU N 154 REMARK 465 ARG N 155 REMARK 465 GLN N 156 REMARK 465 ASN N 157 REMARK 465 GLY N 158 REMARK 465 VAL N 159 REMARK 465 LEU N 160 REMARK 465 ASN N 161 REMARK 465 SER N 162 REMARK 465 TRP N 163 REMARK 465 THR N 164 REMARK 465 ASP N 165 REMARK 465 GLN N 166 REMARK 465 ASP N 167 REMARK 465 SER N 168 REMARK 465 LYS N 169 REMARK 465 ASP N 170 REMARK 465 SER N 171 REMARK 465 THR N 172 REMARK 465 TYR N 173 REMARK 465 SER N 174 REMARK 465 MET N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 THR N 178 REMARK 465 LEU N 179 REMARK 465 THR N 180 REMARK 465 LEU N 181 REMARK 465 THR N 182 REMARK 465 LYS N 183 REMARK 465 ASP N 184 REMARK 465 GLU N 185 REMARK 465 TYR N 186 REMARK 465 GLU N 187 REMARK 465 ARG N 188 REMARK 465 HIS N 189 REMARK 465 ASN N 190 REMARK 465 SER N 191 REMARK 465 TYR N 192 REMARK 465 THR N 193 REMARK 465 CYS N 194 REMARK 465 GLU N 195 REMARK 465 ALA N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 LYS N 199 REMARK 465 THR N 200 REMARK 465 SER N 201 REMARK 465 THR N 202 REMARK 465 SER N 203 REMARK 465 PRO N 204 REMARK 465 ILE N 205 REMARK 465 VAL N 206 REMARK 465 LYS N 207 REMARK 465 SER N 208 REMARK 465 PHE N 209 REMARK 465 ASN N 210 REMARK 465 ARG N 211 REMARK 465 ASN N 212 REMARK 465 GLU N 213 REMARK 465 CYS N 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PHE E 127 CB - CA - C ANGL. DEV. = 17.5 DEGREES REMARK 500 PHE E 127 N - CA - CB ANGL. DEV. = -17.0 DEGREES REMARK 500 PHE F 127 CB - CA - C ANGL. DEV. = 17.4 DEGREES REMARK 500 PHE F 127 N - CA - CB ANGL. DEV. = -17.0 DEGREES REMARK 500 PHE G 127 CB - CA - C ANGL. DEV. = 17.4 DEGREES REMARK 500 PHE G 127 N - CA - CB ANGL. DEV. = -16.9 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA E 155 71.44 54.12 REMARK 500 ALA E 240 -143.16 40.93 REMARK 500 ARG E 335 148.17 67.96 REMARK 500 ARG E 505 19.41 55.08 REMARK 500 ASN E 546 82.17 -161.94 REMARK 500 LEU E 564 57.99 -95.08 REMARK 500 GLN E 609 -2.11 69.51 REMARK 500 SER E 656 -60.04 -100.41 REMARK 500 ALA F 155 71.43 54.08 REMARK 500 ALA F 240 -143.13 40.93 REMARK 500 ARG F 335 148.18 67.99 REMARK 500 ARG F 505 19.36 55.13 REMARK 500 ASN F 546 82.15 -161.94 REMARK 500 LEU F 564 57.94 -95.09 REMARK 500 GLN F 609 -2.10 69.55 REMARK 500 SER F 656 -60.08 -100.35 REMARK 500 ALA G 155 71.40 54.14 REMARK 500 ALA G 240 -143.17 40.95 REMARK 500 ARG G 335 148.14 67.93 REMARK 500 ARG G 505 19.41 55.12 REMARK 500 ASN G 546 82.18 -161.92 REMARK 500 LEU G 564 57.95 -95.06 REMARK 500 GLN G 609 -2.15 69.52 REMARK 500 SER G 656 -60.04 -100.44 REMARK 500 SER H 16 -2.13 82.64 REMARK 500 PHE H 103 42.04 -150.92 REMARK 500 SER I 16 -2.17 82.67 REMARK 500 PHE I 103 42.04 -150.90 REMARK 500 SER J 16 -2.09 82.62 REMARK 500 PHE J 103 41.98 -150.91 REMARK 500 THR L 51 79.45 60.26 REMARK 500 SER L 52 12.95 87.65 REMARK 500 TYR L 91 23.03 -141.07 REMARK 500 THR M 51 79.49 60.29 REMARK 500 SER M 52 13.02 87.58 REMARK 500 TYR M 91 23.05 -141.08 REMARK 500 THR N 51 79.44 60.23 REMARK 500 SER N 52 12.93 87.69 REMARK 500 TYR N 91 23.04 -141.09 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-46758 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF NEUTRALIZING MURINE ANTIBODY WS.HSV-1.24 IN REMARK 900 COMPLEX WITH HSV-1 GLYCOPROTEIN B TRIMER GB-ECTO.516P.531E DBREF 9DD6 E 1 728 UNP A1Z0P7 A1Z0P7_HHV1 1 728 DBREF 9DD6 F 1 728 UNP A1Z0P7 A1Z0P7_HHV1 1 728 DBREF 9DD6 G 1 728 UNP A1Z0P7 A1Z0P7_HHV1 1 728 DBREF 9DD6 H 1 219 PDB 9DD6 9DD6 1 219 DBREF 9DD6 I 1 219 PDB 9DD6 9DD6 1 219 DBREF 9DD6 J 1 219 PDB 9DD6 9DD6 1 219 DBREF 9DD6 L 1 214 PDB 9DD6 9DD6 1 214 DBREF 9DD6 M 1 214 PDB 9DD6 9DD6 1 214 DBREF 9DD6 N 1 214 PDB 9DD6 9DD6 1 214 SEQADV 9DD6 PRO E 516 UNP A1Z0P7 HIS 516 ENGINEERED MUTATION SEQADV 9DD6 GLU E 531 UNP A1Z0P7 LEU 531 ENGINEERED MUTATION SEQADV 9DD6 GLY E 729 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 730 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 731 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TYR E 732 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ILE E 733 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO E 734 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU E 735 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA E 736 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO E 737 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG E 738 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ASP E 739 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 740 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN E 741 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA E 742 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TYR E 743 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL E 744 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG E 745 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS E 746 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ASP E 747 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 748 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU E 749 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP E 750 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL E 751 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU E 752 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU E 753 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 754 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 THR E 755 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE E 756 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU E 757 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 758 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG E 759 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 760 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU E 761 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU E 762 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL E 763 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU E 764 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE E 765 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN E 766 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 767 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO E 768 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 769 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 770 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 771 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 772 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 773 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 774 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 775 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 776 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 777 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 778 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA E 779 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP E 780 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 781 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 782 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO E 783 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN E 784 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE E 785 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU E 786 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS E 787 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 788 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 789 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 790 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 791 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 792 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 793 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 794 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 795 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 796 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 797 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY E 798 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 799 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA E 800 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP E 801 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER E 802 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS E 803 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO E 804 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN E 805 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE E 806 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU E 807 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS E 808 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO F 516 UNP A1Z0P7 HIS 516 ENGINEERED MUTATION SEQADV 9DD6 GLU F 531 UNP A1Z0P7 LEU 531 ENGINEERED MUTATION SEQADV 9DD6 GLY F 729 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 730 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 731 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TYR F 732 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ILE F 733 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO F 734 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU F 735 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA F 736 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO F 737 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG F 738 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ASP F 739 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 740 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN F 741 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA F 742 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TYR F 743 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL F 744 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG F 745 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS F 746 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ASP F 747 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 748 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU F 749 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP F 750 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL F 751 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU F 752 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU F 753 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 754 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 THR F 755 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE F 756 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU F 757 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 758 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG F 759 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 760 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU F 761 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU F 762 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL F 763 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU F 764 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE F 765 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN F 766 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 767 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO F 768 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 769 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 770 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 771 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 772 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 773 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 774 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 775 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 776 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 777 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 778 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA F 779 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP F 780 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 781 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 782 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO F 783 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN F 784 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE F 785 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU F 786 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS F 787 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 788 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 789 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 790 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 791 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 792 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 793 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 794 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 795 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 796 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 797 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY F 798 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 799 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA F 800 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP F 801 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER F 802 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS F 803 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO F 804 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN F 805 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE F 806 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU F 807 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS F 808 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO G 516 UNP A1Z0P7 HIS 516 ENGINEERED MUTATION SEQADV 9DD6 GLU G 531 UNP A1Z0P7 LEU 531 ENGINEERED MUTATION SEQADV 9DD6 GLY G 729 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 730 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 731 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TYR G 732 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ILE G 733 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO G 734 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU G 735 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA G 736 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO G 737 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG G 738 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ASP G 739 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 740 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN G 741 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA G 742 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TYR G 743 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL G 744 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG G 745 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS G 746 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ASP G 747 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 748 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU G 749 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP G 750 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL G 751 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU G 752 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU G 753 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 754 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 THR G 755 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE G 756 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU G 757 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 758 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ARG G 759 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 760 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU G 761 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU G 762 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 VAL G 763 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LEU G 764 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE G 765 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN G 766 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 767 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO G 768 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 769 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 770 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 771 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 772 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 773 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 774 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 775 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 776 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 777 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 778 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA G 779 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP G 780 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 781 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 782 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO G 783 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN G 784 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE G 785 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU G 786 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS G 787 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 788 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 789 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 790 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 791 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 792 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 793 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 794 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 795 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 796 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 797 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLY G 798 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 799 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 ALA G 800 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 TRP G 801 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 SER G 802 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 HIS G 803 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PRO G 804 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLN G 805 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 PHE G 806 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 GLU G 807 UNP A1Z0P7 EXPRESSION TAG SEQADV 9DD6 LYS G 808 UNP A1Z0P7 EXPRESSION TAG SEQRES 1 E 808 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 E 808 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 E 808 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 E 808 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 E 808 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 E 808 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 E 808 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 E 808 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 E 808 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 E 808 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 E 808 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 E 808 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 E 808 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 E 808 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 E 808 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 E 808 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 E 808 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 E 808 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 E 808 LYS PRO ALA ASN ALA ALA THR ARG THR SER ARG GLY TRP SEQRES 20 E 808 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 E 808 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 E 808 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 E 808 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 E 808 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 E 808 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 E 808 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 E 808 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 E 808 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 E 808 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 E 808 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 E 808 ILE SER THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 E 808 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 E 808 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 E 808 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 E 808 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 E 808 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 E 808 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 E 808 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 E 808 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 E 808 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 E 808 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU GLU GLN ASN SEQRES 42 E 808 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 E 808 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 E 808 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 E 808 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 E 808 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 E 808 ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY PRO SEQRES 48 E 808 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 E 808 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 E 808 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 E 808 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 E 808 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 E 808 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 E 808 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 E 808 THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU ARG SEQRES 56 E 808 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 E 808 GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN SEQRES 58 E 808 ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER SEQRES 59 E 808 THR PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY SEQRES 60 E 808 PRO GLY HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SEQRES 61 E 808 SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY SEQRES 62 E 808 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 63 E 808 GLU LYS SEQRES 1 F 808 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 F 808 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 F 808 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 F 808 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 F 808 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 F 808 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 F 808 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 F 808 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 F 808 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 F 808 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 F 808 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 F 808 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 F 808 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 F 808 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 F 808 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 F 808 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 F 808 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 F 808 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 F 808 LYS PRO ALA ASN ALA ALA THR ARG THR SER ARG GLY TRP SEQRES 20 F 808 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 F 808 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 F 808 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 F 808 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 F 808 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 F 808 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 F 808 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 F 808 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 F 808 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 F 808 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 F 808 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 F 808 ILE SER THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 F 808 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 F 808 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 F 808 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 F 808 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 F 808 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 F 808 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 F 808 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 F 808 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 F 808 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 F 808 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU GLU GLN ASN SEQRES 42 F 808 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 F 808 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 F 808 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 F 808 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 F 808 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 F 808 ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY PRO SEQRES 48 F 808 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 F 808 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 F 808 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 F 808 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 F 808 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 F 808 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 F 808 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 F 808 THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU ARG SEQRES 56 F 808 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 F 808 GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN SEQRES 58 F 808 ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER SEQRES 59 F 808 THR PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY SEQRES 60 F 808 PRO GLY HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SEQRES 61 F 808 SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY SEQRES 62 F 808 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 63 F 808 GLU LYS SEQRES 1 G 808 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 G 808 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 G 808 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 G 808 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 G 808 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 G 808 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 G 808 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 G 808 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 G 808 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 G 808 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 G 808 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 G 808 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 G 808 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 G 808 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 G 808 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 G 808 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 G 808 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 G 808 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 G 808 LYS PRO ALA ASN ALA ALA THR ARG THR SER ARG GLY TRP SEQRES 20 G 808 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 G 808 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 G 808 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 G 808 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 G 808 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 G 808 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 G 808 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 G 808 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 G 808 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 G 808 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 G 808 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 G 808 ILE SER THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 G 808 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 G 808 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 G 808 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 G 808 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 G 808 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 G 808 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 G 808 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 G 808 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 G 808 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 G 808 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU GLU GLN ASN SEQRES 42 G 808 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 G 808 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 G 808 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 G 808 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 G 808 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 G 808 ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY PRO SEQRES 48 G 808 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 G 808 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 G 808 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 G 808 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 G 808 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 G 808 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 G 808 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 G 808 THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU ARG SEQRES 56 G 808 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 G 808 GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN SEQRES 58 G 808 ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER SEQRES 59 G 808 THR PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY SEQRES 60 G 808 PRO GLY HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SEQRES 61 G 808 SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY SEQRES 62 G 808 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 63 G 808 GLU LYS SEQRES 1 H 218 GLN VAL GLN LEU LYS GLU SER GLY PRO GLY LEU VAL ALA SEQRES 2 H 218 PRO SER GLN SER LEU SER ILE THR CYS THR VAL SER GLY SEQRES 3 H 218 PHE SER LEU THR THR TYR GLY VAL THR TRP VAL ARG GLN SEQRES 4 H 218 PRO PRO GLY LYS GLY LEU GLU TRP LEU GLY VAL ILE TRP SEQRES 5 H 218 GLY ASP GLY SER THR ASN TYR HIS SER ASP LEU ILE SER SEQRES 6 H 218 ARG LEU SER ILE THR LYS ASP ASN SER LYS SER GLN VAL SEQRES 7 H 218 PHE LEU LYS LEU SER SER LEU GLN ALA ASP ASP THR ALA SEQRES 8 H 218 THR TYR TYR CYS VAL SER TYR TYR GLY TYR PHE ASP HIS SEQRES 9 H 218 TRP GLY GLN GLY THR THR LEU THR VAL SER SER ALA SER SEQRES 10 H 218 THR THR PRO PRO SER VAL TYR PRO LEU ALA PRO GLY SER SEQRES 11 H 218 ALA ALA GLN THR ASN SER MET VAL THR LEU GLY CYS LEU SEQRES 12 H 218 VAL LYS GLY TYR PHE PRO GLU PRO VAL THR VAL THR TRP SEQRES 13 H 218 ASN SER GLY SER LEU SER SER GLY VAL HIS THR PHE PRO SEQRES 14 H 218 ALA VAL LEU GLN SER ASP LEU TYR THR LEU SER SER SER SEQRES 15 H 218 VAL THR VAL PRO SER SER THR TRP PRO SER GLU THR VAL SEQRES 16 H 218 THR CYS ASN VAL ALA HIS PRO ALA SER SER THR LYS VAL SEQRES 17 H 218 ASP LYS LYS ILE VAL PRO ARG ASP CYS GLY SEQRES 1 I 218 GLN VAL GLN LEU LYS GLU SER GLY PRO GLY LEU VAL ALA SEQRES 2 I 218 PRO SER GLN SER LEU SER ILE THR CYS THR VAL SER GLY SEQRES 3 I 218 PHE SER LEU THR THR TYR GLY VAL THR TRP VAL ARG GLN SEQRES 4 I 218 PRO PRO GLY LYS GLY LEU GLU TRP LEU GLY VAL ILE TRP SEQRES 5 I 218 GLY ASP GLY SER THR ASN TYR HIS SER ASP LEU ILE SER SEQRES 6 I 218 ARG LEU SER ILE THR LYS ASP ASN SER LYS SER GLN VAL SEQRES 7 I 218 PHE LEU LYS LEU SER SER LEU GLN ALA ASP ASP THR ALA SEQRES 8 I 218 THR TYR TYR CYS VAL SER TYR TYR GLY TYR PHE ASP HIS SEQRES 9 I 218 TRP GLY GLN GLY THR THR LEU THR VAL SER SER ALA SER SEQRES 10 I 218 THR THR PRO PRO SER VAL TYR PRO LEU ALA PRO GLY SER SEQRES 11 I 218 ALA ALA GLN THR ASN SER MET VAL THR LEU GLY CYS LEU SEQRES 12 I 218 VAL LYS GLY TYR PHE PRO GLU PRO VAL THR VAL THR TRP SEQRES 13 I 218 ASN SER GLY SER LEU SER SER GLY VAL HIS THR PHE PRO SEQRES 14 I 218 ALA VAL LEU GLN SER ASP LEU TYR THR LEU SER SER SER SEQRES 15 I 218 VAL THR VAL PRO SER SER THR TRP PRO SER GLU THR VAL SEQRES 16 I 218 THR CYS ASN VAL ALA HIS PRO ALA SER SER THR LYS VAL SEQRES 17 I 218 ASP LYS LYS ILE VAL PRO ARG ASP CYS GLY SEQRES 1 J 218 GLN VAL GLN LEU LYS GLU SER GLY PRO GLY LEU VAL ALA SEQRES 2 J 218 PRO SER GLN SER LEU SER ILE THR CYS THR VAL SER GLY SEQRES 3 J 218 PHE SER LEU THR THR TYR GLY VAL THR TRP VAL ARG GLN SEQRES 4 J 218 PRO PRO GLY LYS GLY LEU GLU TRP LEU GLY VAL ILE TRP SEQRES 5 J 218 GLY ASP GLY SER THR ASN TYR HIS SER ASP LEU ILE SER SEQRES 6 J 218 ARG LEU SER ILE THR LYS ASP ASN SER LYS SER GLN VAL SEQRES 7 J 218 PHE LEU LYS LEU SER SER LEU GLN ALA ASP ASP THR ALA SEQRES 8 J 218 THR TYR TYR CYS VAL SER TYR TYR GLY TYR PHE ASP HIS SEQRES 9 J 218 TRP GLY GLN GLY THR THR LEU THR VAL SER SER ALA SER SEQRES 10 J 218 THR THR PRO PRO SER VAL TYR PRO LEU ALA PRO GLY SER SEQRES 11 J 218 ALA ALA GLN THR ASN SER MET VAL THR LEU GLY CYS LEU SEQRES 12 J 218 VAL LYS GLY TYR PHE PRO GLU PRO VAL THR VAL THR TRP SEQRES 13 J 218 ASN SER GLY SER LEU SER SER GLY VAL HIS THR PHE PRO SEQRES 14 J 218 ALA VAL LEU GLN SER ASP LEU TYR THR LEU SER SER SER SEQRES 15 J 218 VAL THR VAL PRO SER SER THR TRP PRO SER GLU THR VAL SEQRES 16 J 218 THR CYS ASN VAL ALA HIS PRO ALA SER SER THR LYS VAL SEQRES 17 J 218 ASP LYS LYS ILE VAL PRO ARG ASP CYS GLY SEQRES 1 L 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 214 SER LEU GLY GLU ARG VAL SER LEU THR CYS ARG ALA SER SEQRES 3 L 214 GLN ASP ILE GLY SER SER LEU ASN TRP LEU GLN GLN LYS SEQRES 4 L 214 PRO ASP GLY THR ILE LYS ARG LEU ILE TYR ALA THR SER SEQRES 5 L 214 SER LEU ASP SER GLY VAL PRO LYS ARG PHE SER GLY SER SEQRES 6 L 214 ARG SER GLY SER ASP TYR SER LEU THR ILE SER SER LEU SEQRES 7 L 214 GLU SER GLU ASP PHE VAL ASP TYR TYR CYS LEU GLN TYR SEQRES 8 L 214 ALA SER SER PRO PRO THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 L 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 L 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 L 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 L 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 L 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 L 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 L 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 L 214 PHE ASN ARG ASN GLU CYS SEQRES 1 M 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 M 214 SER LEU GLY GLU ARG VAL SER LEU THR CYS ARG ALA SER SEQRES 3 M 214 GLN ASP ILE GLY SER SER LEU ASN TRP LEU GLN GLN LYS SEQRES 4 M 214 PRO ASP GLY THR ILE LYS ARG LEU ILE TYR ALA THR SER SEQRES 5 M 214 SER LEU ASP SER GLY VAL PRO LYS ARG PHE SER GLY SER SEQRES 6 M 214 ARG SER GLY SER ASP TYR SER LEU THR ILE SER SER LEU SEQRES 7 M 214 GLU SER GLU ASP PHE VAL ASP TYR TYR CYS LEU GLN TYR SEQRES 8 M 214 ALA SER SER PRO PRO THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 M 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 M 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 M 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 M 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 M 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 M 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 M 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 M 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 M 214 PHE ASN ARG ASN GLU CYS SEQRES 1 N 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 N 214 SER LEU GLY GLU ARG VAL SER LEU THR CYS ARG ALA SER SEQRES 3 N 214 GLN ASP ILE GLY SER SER LEU ASN TRP LEU GLN GLN LYS SEQRES 4 N 214 PRO ASP GLY THR ILE LYS ARG LEU ILE TYR ALA THR SER SEQRES 5 N 214 SER LEU ASP SER GLY VAL PRO LYS ARG PHE SER GLY SER SEQRES 6 N 214 ARG SER GLY SER ASP TYR SER LEU THR ILE SER SER LEU SEQRES 7 N 214 GLU SER GLU ASP PHE VAL ASP TYR TYR CYS LEU GLN TYR SEQRES 8 N 214 ALA SER SER PRO PRO THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 N 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 N 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 N 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 N 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 N 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 N 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 N 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 N 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 N 214 PHE ASN ARG ASN GLU CYS HET NAG A 1 14 HET NAG A 2 14 HET NAG B 1 14 HET NAG B 2 14 HET BMA B 3 11 HET NAG C 1 14 HET NAG C 2 14 HET NAG D 1 14 HET NAG D 2 14 HET BMA D 3 11 HET NAG K 1 14 HET NAG K 2 14 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET NAG E 901 14 HET NAG E 902 14 HET NAG F 901 14 HET NAG F 902 14 HET NAG G 901 14 HET NAG G 902 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 18(C8 H15 N O6) FORMUL 11 BMA 3(C6 H12 O6) HELIX 1 AA1 PRO E 193 LYS E 200 1 8 HELIX 2 AA2 LYS E 200 GLY E 205 1 6 HELIX 3 AA3 PHE E 223 ASP E 227 5 5 HELIX 4 AA4 GLY E 306 GLU E 310 5 5 HELIX 5 AA5 ALA E 315 ASP E 317 5 3 HELIX 6 AA6 PRO E 403 ASP E 408 5 6 HELIX 7 AA7 LEU E 409 TYR E 429 1 21 HELIX 8 AA8 ASN E 458 SER E 473 1 16 HELIX 9 AA9 TYR E 510 ASN E 546 1 37 HELIX 10 AB1 ASN E 546 GLY E 556 1 11 HELIX 11 AB2 ALA E 577 ASP E 579 5 3 HELIX 12 AB3 SER E 660 ILE E 664 5 5 HELIX 13 AB4 LEU E 686 ARG E 691 1 6 HELIX 14 AB5 ASP E 701 THR E 721 1 21 HELIX 15 AB6 PRO F 193 LYS F 200 1 8 HELIX 16 AB7 LYS F 200 GLY F 205 1 6 HELIX 17 AB8 PHE F 223 ASP F 227 5 5 HELIX 18 AB9 GLY F 306 GLU F 310 5 5 HELIX 19 AC1 ALA F 315 ASP F 317 5 3 HELIX 20 AC2 PRO F 403 ASP F 408 5 6 HELIX 21 AC3 LEU F 409 TYR F 429 1 21 HELIX 22 AC4 ASN F 458 SER F 473 1 16 HELIX 23 AC5 TYR F 510 ASN F 546 1 37 HELIX 24 AC6 ASN F 546 GLY F 556 1 11 HELIX 25 AC7 ALA F 577 ASP F 579 5 3 HELIX 26 AC8 SER F 660 ILE F 664 5 5 HELIX 27 AC9 LEU F 686 ARG F 691 1 6 HELIX 28 AD1 ASP F 701 THR F 721 1 21 HELIX 29 AD2 PRO G 193 LYS G 200 1 8 HELIX 30 AD3 LYS G 200 GLY G 205 1 6 HELIX 31 AD4 PHE G 223 ASP G 227 5 5 HELIX 32 AD5 GLY G 306 GLU G 310 5 5 HELIX 33 AD6 ALA G 315 ASP G 317 5 3 HELIX 34 AD7 PRO G 403 ASP G 408 5 6 HELIX 35 AD8 LEU G 409 TYR G 429 1 21 HELIX 36 AD9 ASN G 458 SER G 473 1 16 HELIX 37 AE1 TYR G 510 ASN G 546 1 37 HELIX 38 AE2 ASN G 546 GLY G 556 1 11 HELIX 39 AE3 ALA G 577 ASP G 579 5 3 HELIX 40 AE4 SER G 660 ILE G 664 5 5 HELIX 41 AE5 LEU G 686 ARG G 691 1 6 HELIX 42 AE6 ASP G 701 THR G 721 1 21 HELIX 43 AE7 GLN H 87 THR H 91 5 5 HELIX 44 AE8 GLN I 87 THR I 91 5 5 HELIX 45 AE9 GLN J 87 THR J 91 5 5 SHEET 1 AA1 2 PHE E 113 VAL E 115 0 SHEET 2 AA1 2 VAL E 574 VAL E 576 -1 O VAL E 576 N PHE E 113 SHEET 1 AA2 4 VAL E 559 MET E 563 0 SHEET 2 AA2 4 MET E 568 THR E 572 -1 O SER E 571 N SER E 560 SHEET 3 AA2 4 THR E 123 GLN E 126 -1 N VAL E 125 O MET E 568 SHEET 4 AA2 4 THR F 665 THR F 666 1 O THR F 665 N GLN E 126 SHEET 1 AA3 6 PHE E 395 THR E 397 0 SHEET 2 AA3 6 SER E 383 SER E 388 -1 N PHE E 386 O PHE E 395 SHEET 3 AA3 6 MET E 366 TYR E 380 -1 N LEU E 376 O SER E 387 SHEET 4 AA3 6 GLN E 140 GLU E 152 -1 N GLN E 140 O GLU E 379 SHEET 5 AA3 6 PHE E 448 SER E 457 -1 O LEU E 455 N GLU E 144 SHEET 6 AA3 6 HIS E 433 LYS E 435 -1 N ILE E 434 O LEU E 456 SHEET 1 AA4 6 PHE E 395 THR E 397 0 SHEET 2 AA4 6 SER E 383 SER E 388 -1 N PHE E 386 O PHE E 395 SHEET 3 AA4 6 MET E 366 TYR E 380 -1 N LEU E 376 O SER E 387 SHEET 4 AA4 6 GLN E 140 GLU E 152 -1 N GLN E 140 O GLU E 379 SHEET 5 AA4 6 PHE E 448 SER E 457 -1 O LEU E 455 N GLU E 144 SHEET 6 AA4 6 GLN E 440 ALA E 444 -1 N GLN E 440 O TYR E 452 SHEET 1 AA5 5 ASP E 188 ALA E 190 0 SHEET 2 AA5 5 TYR E 157 THR E 169 -1 N LYS E 166 O ALA E 190 SHEET 3 AA5 5 THR E 268 SER E 280 -1 O GLU E 274 N MET E 163 SHEET 4 AA5 5 PHE E 287 LEU E 289 -1 O VAL E 288 N ARG E 279 SHEET 5 AA5 5 PHE E 294 VAL E 295 -1 O VAL E 295 N PHE E 287 SHEET 1 AA6 7 LYS E 235 PRO E 236 0 SHEET 2 AA6 7 GLY E 246 HIS E 248 -1 O HIS E 248 N LYS E 235 SHEET 3 AA6 7 THR E 268 SER E 280 -1 O VAL E 273 N TRP E 247 SHEET 4 AA6 7 TYR E 157 THR E 169 -1 N MET E 163 O GLU E 274 SHEET 5 AA6 7 THR E 351 ASP E 355 -1 O THR E 351 N TYR E 164 SHEET 6 AA6 7 ARG E 342 THR E 346 -1 N LEU E 345 O VAL E 352 SHEET 7 AA6 7 PHE E 319 VAL E 322 -1 N VAL E 322 O ARG E 342 SHEET 1 AA7 2 VAL E 206 ARG E 208 0 SHEET 2 AA7 2 ASP E 231 GLU E 233 -1 O MET E 232 N CYS E 207 SHEET 1 AA8 2 ALA E 211 VAL E 214 0 SHEET 2 AA8 2 GLU E 219 ALA E 222 -1 O THR E 220 N TYR E 213 SHEET 1 AA9 4 VAL E 581 VAL E 583 0 SHEET 2 AA9 4 LEU E 601 PHE E 604 -1 O SER E 603 N ILE E 582 SHEET 3 AA9 4 VAL E 613 LEU E 617 -1 O VAL E 613 N PHE E 604 SHEET 4 AA9 4 LEU E 623 ARG E 624 -1 O ARG E 624 N GLN E 616 SHEET 1 AB1 2 ALA E 595 TYR E 597 0 SHEET 2 AB1 2 ILE E 630 PRO E 632 -1 O GLU E 631 N CYS E 596 SHEET 1 AB2 3 ARG E 638 PHE E 643 0 SHEET 2 AB2 3 GLY E 646 GLU E 651 -1 O PHE E 650 N ARG E 639 SHEET 3 AB2 3 ALA E 654 LEU E 659 -1 O LEU E 659 N TYR E 647 SHEET 1 AB3 4 THR E 665 THR E 666 0 SHEET 2 AB3 4 THR G 123 GLN G 126 1 O GLN G 126 N THR E 665 SHEET 3 AB3 4 MET G 568 THR G 572 -1 O MET G 568 N VAL G 125 SHEET 4 AB3 4 VAL G 559 MET G 563 -1 N SER G 560 O SER G 571 SHEET 1 AB4 2 PHE F 113 VAL F 115 0 SHEET 2 AB4 2 VAL F 574 VAL F 576 -1 O VAL F 576 N PHE F 113 SHEET 1 AB5 4 VAL F 559 MET F 563 0 SHEET 2 AB5 4 MET F 568 THR F 572 -1 O SER F 571 N SER F 560 SHEET 3 AB5 4 THR F 123 GLN F 126 -1 N VAL F 125 O MET F 568 SHEET 4 AB5 4 THR G 665 THR G 666 1 O THR G 665 N GLN F 126 SHEET 1 AB6 6 PHE F 395 THR F 397 0 SHEET 2 AB6 6 SER F 383 SER F 388 -1 N PHE F 386 O PHE F 395 SHEET 3 AB6 6 MET F 366 TYR F 380 -1 N LEU F 376 O SER F 387 SHEET 4 AB6 6 GLN F 140 GLU F 152 -1 N GLN F 140 O GLU F 379 SHEET 5 AB6 6 PHE F 448 SER F 457 -1 O LEU F 455 N GLU F 144 SHEET 6 AB6 6 HIS F 433 LYS F 435 -1 N ILE F 434 O LEU F 456 SHEET 1 AB7 6 PHE F 395 THR F 397 0 SHEET 2 AB7 6 SER F 383 SER F 388 -1 N PHE F 386 O PHE F 395 SHEET 3 AB7 6 MET F 366 TYR F 380 -1 N LEU F 376 O SER F 387 SHEET 4 AB7 6 GLN F 140 GLU F 152 -1 N GLN F 140 O GLU F 379 SHEET 5 AB7 6 PHE F 448 SER F 457 -1 O LEU F 455 N GLU F 144 SHEET 6 AB7 6 GLN F 440 ALA F 444 -1 N GLN F 440 O TYR F 452 SHEET 1 AB8 5 ASP F 188 ALA F 190 0 SHEET 2 AB8 5 TYR F 157 THR F 169 -1 N LYS F 166 O ALA F 190 SHEET 3 AB8 5 THR F 268 SER F 280 -1 O GLU F 274 N MET F 163 SHEET 4 AB8 5 PHE F 287 LEU F 289 -1 O VAL F 288 N ARG F 279 SHEET 5 AB8 5 PHE F 294 VAL F 295 -1 O VAL F 295 N PHE F 287 SHEET 1 AB9 7 LYS F 235 PRO F 236 0 SHEET 2 AB9 7 GLY F 246 HIS F 248 -1 O HIS F 248 N LYS F 235 SHEET 3 AB9 7 THR F 268 SER F 280 -1 O VAL F 273 N TRP F 247 SHEET 4 AB9 7 TYR F 157 THR F 169 -1 N MET F 163 O GLU F 274 SHEET 5 AB9 7 THR F 351 ASP F 355 -1 O THR F 351 N TYR F 164 SHEET 6 AB9 7 ARG F 342 THR F 346 -1 N LEU F 345 O VAL F 352 SHEET 7 AB9 7 PHE F 319 VAL F 322 -1 N VAL F 322 O ARG F 342 SHEET 1 AC1 2 VAL F 206 ARG F 208 0 SHEET 2 AC1 2 ASP F 231 GLU F 233 -1 O MET F 232 N CYS F 207 SHEET 1 AC2 2 ALA F 211 VAL F 214 0 SHEET 2 AC2 2 GLU F 219 ALA F 222 -1 O THR F 220 N TYR F 213 SHEET 1 AC3 4 VAL F 581 VAL F 583 0 SHEET 2 AC3 4 LEU F 601 PHE F 604 -1 O SER F 603 N ILE F 582 SHEET 3 AC3 4 VAL F 613 LEU F 617 -1 O VAL F 613 N PHE F 604 SHEET 4 AC3 4 LEU F 623 ARG F 624 -1 O ARG F 624 N GLN F 616 SHEET 1 AC4 2 ALA F 595 TYR F 597 0 SHEET 2 AC4 2 ILE F 630 PRO F 632 -1 O GLU F 631 N CYS F 596 SHEET 1 AC5 3 ARG F 638 PHE F 643 0 SHEET 2 AC5 3 GLY F 646 GLU F 651 -1 O PHE F 650 N ARG F 639 SHEET 3 AC5 3 ALA F 654 LEU F 659 -1 O LEU F 659 N TYR F 647 SHEET 1 AC6 2 PHE G 113 VAL G 115 0 SHEET 2 AC6 2 VAL G 574 VAL G 576 -1 O VAL G 576 N PHE G 113 SHEET 1 AC7 6 PHE G 395 THR G 397 0 SHEET 2 AC7 6 SER G 383 SER G 388 -1 N PHE G 386 O PHE G 395 SHEET 3 AC7 6 MET G 366 TYR G 380 -1 N LEU G 376 O SER G 387 SHEET 4 AC7 6 GLN G 140 GLU G 152 -1 N GLN G 140 O GLU G 379 SHEET 5 AC7 6 PHE G 448 SER G 457 -1 O LEU G 455 N GLU G 144 SHEET 6 AC7 6 HIS G 433 LYS G 435 -1 N ILE G 434 O LEU G 456 SHEET 1 AC8 6 PHE G 395 THR G 397 0 SHEET 2 AC8 6 SER G 383 SER G 388 -1 N PHE G 386 O PHE G 395 SHEET 3 AC8 6 MET G 366 TYR G 380 -1 N LEU G 376 O SER G 387 SHEET 4 AC8 6 GLN G 140 GLU G 152 -1 N GLN G 140 O GLU G 379 SHEET 5 AC8 6 PHE G 448 SER G 457 -1 O LEU G 455 N GLU G 144 SHEET 6 AC8 6 GLN G 440 ALA G 444 -1 N GLN G 440 O TYR G 452 SHEET 1 AC9 5 ASP G 188 ALA G 190 0 SHEET 2 AC9 5 TYR G 157 THR G 169 -1 N LYS G 166 O ALA G 190 SHEET 3 AC9 5 THR G 268 SER G 280 -1 O GLU G 274 N MET G 163 SHEET 4 AC9 5 PHE G 287 LEU G 289 -1 O VAL G 288 N ARG G 279 SHEET 5 AC9 5 PHE G 294 VAL G 295 -1 O VAL G 295 N PHE G 287 SHEET 1 AD1 7 LYS G 235 PRO G 236 0 SHEET 2 AD1 7 GLY G 246 HIS G 248 -1 O HIS G 248 N LYS G 235 SHEET 3 AD1 7 THR G 268 SER G 280 -1 O VAL G 273 N TRP G 247 SHEET 4 AD1 7 TYR G 157 THR G 169 -1 N MET G 163 O GLU G 274 SHEET 5 AD1 7 THR G 351 ASP G 355 -1 O THR G 351 N TYR G 164 SHEET 6 AD1 7 ARG G 342 THR G 346 -1 N LEU G 345 O VAL G 352 SHEET 7 AD1 7 PHE G 319 VAL G 322 -1 N VAL G 322 O ARG G 342 SHEET 1 AD2 2 VAL G 206 ARG G 208 0 SHEET 2 AD2 2 ASP G 231 GLU G 233 -1 O MET G 232 N CYS G 207 SHEET 1 AD3 2 ALA G 211 VAL G 214 0 SHEET 2 AD3 2 GLU G 219 ALA G 222 -1 O THR G 220 N TYR G 213 SHEET 1 AD4 4 VAL G 581 VAL G 583 0 SHEET 2 AD4 4 LEU G 601 PHE G 604 -1 O SER G 603 N ILE G 582 SHEET 3 AD4 4 VAL G 613 LEU G 617 -1 O VAL G 613 N PHE G 604 SHEET 4 AD4 4 LEU G 623 ARG G 624 -1 O ARG G 624 N GLN G 616 SHEET 1 AD5 2 ALA G 595 TYR G 597 0 SHEET 2 AD5 2 ILE G 630 PRO G 632 -1 O GLU G 631 N CYS G 596 SHEET 1 AD6 3 ARG G 638 PHE G 643 0 SHEET 2 AD6 3 GLY G 646 GLU G 651 -1 O PHE G 650 N ARG G 639 SHEET 3 AD6 3 ALA G 654 LEU G 659 -1 O LEU G 659 N TYR G 647 SHEET 1 AD7 4 GLN H 3 SER H 7 0 SHEET 2 AD7 4 LEU H 19 SER H 26 -1 O THR H 24 N LYS H 5 SHEET 3 AD7 4 GLN H 78 LEU H 83 -1 O LEU H 81 N ILE H 21 SHEET 4 AD7 4 LEU H 68 ASP H 73 -1 N THR H 71 O PHE H 80 SHEET 1 AD8 6 LEU H 12 VAL H 13 0 SHEET 2 AD8 6 THR H 110 VAL H 114 1 O THR H 113 N VAL H 13 SHEET 3 AD8 6 ALA H 92 SER H 98 -1 N TYR H 94 O THR H 110 SHEET 4 AD8 6 VAL H 35 GLN H 40 -1 N VAL H 38 O TYR H 95 SHEET 5 AD8 6 GLU H 47 ILE H 52 -1 O GLU H 47 N ARG H 39 SHEET 6 AD8 6 THR H 58 TYR H 60 -1 O ASN H 59 N VAL H 51 SHEET 1 AD9 4 GLN I 3 SER I 7 0 SHEET 2 AD9 4 LEU I 19 SER I 26 -1 O THR I 24 N LYS I 5 SHEET 3 AD9 4 GLN I 78 LEU I 83 -1 O LEU I 81 N ILE I 21 SHEET 4 AD9 4 LEU I 68 ASP I 73 -1 N THR I 71 O PHE I 80 SHEET 1 AE1 6 LEU I 12 VAL I 13 0 SHEET 2 AE1 6 THR I 110 VAL I 114 1 O THR I 113 N VAL I 13 SHEET 3 AE1 6 ALA I 92 SER I 98 -1 N TYR I 94 O THR I 110 SHEET 4 AE1 6 VAL I 35 GLN I 40 -1 N VAL I 38 O TYR I 95 SHEET 5 AE1 6 GLU I 47 ILE I 52 -1 O GLU I 47 N ARG I 39 SHEET 6 AE1 6 THR I 58 TYR I 60 -1 O ASN I 59 N VAL I 51 SHEET 1 AE2 4 GLN J 3 SER J 7 0 SHEET 2 AE2 4 LEU J 19 SER J 26 -1 O THR J 24 N LYS J 5 SHEET 3 AE2 4 GLN J 78 LEU J 83 -1 O LEU J 81 N ILE J 21 SHEET 4 AE2 4 LEU J 68 ASP J 73 -1 N THR J 71 O PHE J 80 SHEET 1 AE3 6 LEU J 12 VAL J 13 0 SHEET 2 AE3 6 THR J 110 VAL J 114 1 O THR J 113 N VAL J 13 SHEET 3 AE3 6 ALA J 92 SER J 98 -1 N TYR J 94 O THR J 110 SHEET 4 AE3 6 VAL J 35 GLN J 40 -1 N VAL J 38 O TYR J 95 SHEET 5 AE3 6 GLU J 47 ILE J 52 -1 O GLU J 47 N ARG J 39 SHEET 6 AE3 6 THR J 58 TYR J 60 -1 O ASN J 59 N VAL J 51 SHEET 1 AE4 4 MET L 4 SER L 7 0 SHEET 2 AE4 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AE4 4 ASP L 70 ILE L 75 -1 O TYR L 71 N CYS L 23 SHEET 4 AE4 4 PHE L 62 SER L 67 -1 N SER L 67 O ASP L 70 SHEET 1 AE5 6 SER L 10 ALA L 13 0 SHEET 2 AE5 6 THR L 102 ILE L 106 1 O GLU L 105 N LEU L 11 SHEET 3 AE5 6 ASP L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AE5 6 LEU L 33 GLN L 38 -1 N ASN L 34 O LEU L 89 SHEET 5 AE5 6 ILE L 44 TYR L 49 -1 O LYS L 45 N GLN L 37 SHEET 6 AE5 6 SER L 53 LEU L 54 -1 O SER L 53 N TYR L 49 SHEET 1 AE6 4 SER L 10 ALA L 13 0 SHEET 2 AE6 4 THR L 102 ILE L 106 1 O GLU L 105 N LEU L 11 SHEET 3 AE6 4 ASP L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AE6 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AE7 4 MET M 4 SER M 7 0 SHEET 2 AE7 4 VAL M 19 ALA M 25 -1 O ARG M 24 N THR M 5 SHEET 3 AE7 4 ASP M 70 ILE M 75 -1 O TYR M 71 N CYS M 23 SHEET 4 AE7 4 PHE M 62 SER M 67 -1 N SER M 67 O ASP M 70 SHEET 1 AE8 6 SER M 10 ALA M 13 0 SHEET 2 AE8 6 THR M 102 ILE M 106 1 O GLU M 105 N LEU M 11 SHEET 3 AE8 6 ASP M 85 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AE8 6 LEU M 33 GLN M 38 -1 N ASN M 34 O LEU M 89 SHEET 5 AE8 6 ILE M 44 TYR M 49 -1 O LYS M 45 N GLN M 37 SHEET 6 AE8 6 SER M 53 LEU M 54 -1 O SER M 53 N TYR M 49 SHEET 1 AE9 4 SER M 10 ALA M 13 0 SHEET 2 AE9 4 THR M 102 ILE M 106 1 O GLU M 105 N LEU M 11 SHEET 3 AE9 4 ASP M 85 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AE9 4 THR M 97 PHE M 98 -1 O THR M 97 N GLN M 90 SHEET 1 AF1 4 MET N 4 SER N 7 0 SHEET 2 AF1 4 VAL N 19 ALA N 25 -1 O ARG N 24 N THR N 5 SHEET 3 AF1 4 ASP N 70 ILE N 75 -1 O TYR N 71 N CYS N 23 SHEET 4 AF1 4 PHE N 62 SER N 67 -1 N SER N 67 O ASP N 70 SHEET 1 AF2 6 SER N 10 ALA N 13 0 SHEET 2 AF2 6 THR N 102 ILE N 106 1 O GLU N 105 N LEU N 11 SHEET 3 AF2 6 ASP N 85 GLN N 90 -1 N TYR N 86 O THR N 102 SHEET 4 AF2 6 LEU N 33 GLN N 38 -1 N ASN N 34 O LEU N 89 SHEET 5 AF2 6 ILE N 44 TYR N 49 -1 O LYS N 45 N GLN N 37 SHEET 6 AF2 6 SER N 53 LEU N 54 -1 O SER N 53 N TYR N 49 SHEET 1 AF3 4 SER N 10 ALA N 13 0 SHEET 2 AF3 4 THR N 102 ILE N 106 1 O GLU N 105 N LEU N 11 SHEET 3 AF3 4 ASP N 85 GLN N 90 -1 N TYR N 86 O THR N 102 SHEET 4 AF3 4 THR N 97 PHE N 98 -1 O THR N 97 N GLN N 90 SSBOND 1 CYS E 116 CYS E 573 1555 1555 2.03 SSBOND 2 CYS E 133 CYS E 529 1555 1555 2.03 SSBOND 3 CYS E 207 CYS E 271 1555 1555 2.03 SSBOND 4 CYS E 364 CYS E 412 1555 1555 2.03 SSBOND 5 CYS E 596 CYS E 633 1555 1555 2.05 SSBOND 6 CYS F 116 CYS F 573 1555 1555 2.03 SSBOND 7 CYS F 133 CYS F 529 1555 1555 2.03 SSBOND 8 CYS F 207 CYS F 271 1555 1555 2.03 SSBOND 9 CYS F 364 CYS F 412 1555 1555 2.03 SSBOND 10 CYS F 596 CYS F 633 1555 1555 2.05 SSBOND 11 CYS G 116 CYS G 573 1555 1555 2.03 SSBOND 12 CYS G 133 CYS G 529 1555 1555 2.03 SSBOND 13 CYS G 207 CYS G 271 1555 1555 2.03 SSBOND 14 CYS G 364 CYS G 412 1555 1555 2.03 SSBOND 15 CYS G 596 CYS G 633 1555 1555 2.05 SSBOND 16 CYS H 23 CYS H 96 1555 1555 2.03 SSBOND 17 CYS I 23 CYS I 96 1555 1555 2.03 SSBOND 18 CYS J 23 CYS J 96 1555 1555 2.03 SSBOND 19 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 20 CYS M 23 CYS M 88 1555 1555 2.04 SSBOND 21 CYS N 23 CYS N 88 1555 1555 2.03 LINK ND2 ASN E 141 C1 NAG A 1 1555 1555 1.45 LINK ND2 ASN E 398 C1 NAG B 1 1555 1555 1.44 LINK ND2 ASN E 430 C1 NAG E 901 1555 1555 1.44 LINK ND2 ASN E 674 C1 NAG E 902 1555 1555 1.44 LINK ND2 ASN F 141 C1 NAG C 1 1555 1555 1.45 LINK ND2 ASN F 398 C1 NAG D 1 1555 1555 1.44 LINK ND2 ASN F 430 C1 NAG F 901 1555 1555 1.44 LINK ND2 ASN F 674 C1 NAG F 902 1555 1555 1.44 LINK ND2 ASN G 141 C1 NAG K 1 1555 1555 1.45 LINK ND2 ASN G 398 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN G 430 C1 NAG G 901 1555 1555 1.44 LINK ND2 ASN G 674 C1 NAG G 902 1555 1555 1.44 LINK O4 NAG A 1 C1 NAG A 2 1555 1555 1.44 LINK O4 NAG B 1 C1 NAG B 2 1555 1555 1.44 LINK O4 NAG B 2 C1 BMA B 3 1555 1555 1.45 LINK O4 NAG C 1 C1 NAG C 2 1555 1555 1.44 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.44 LINK O4 NAG D 2 C1 BMA D 3 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.45 CISPEP 1 SER L 7 PRO L 8 0 -1.37 CISPEP 2 SER L 94 PRO L 95 0 -2.04 CISPEP 3 SER M 7 PRO M 8 0 -1.42 CISPEP 4 SER M 94 PRO M 95 0 -2.03 CISPEP 5 SER N 7 PRO N 8 0 -1.40 CISPEP 6 SER N 94 PRO N 95 0 -2.01 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000