HEADER VIRAL PROTEIN 27-AUG-24 9DD7 TITLE CRYO-EM STRUCTURE OF NEUTRALIZING HUMAN ANTIBODY D48 IN COMPLEX WITH TITLE 2 HSV-1 GLYCOPROTEIN B TRIMER GB-ECTO.516P.531E.DS COMPND MOL_ID: 1; COMPND 2 MOLECULE: GLYCOPROTEIN B; COMPND 3 CHAIN: E, F, G; COMPND 4 FRAGMENT: HSV-1 GB ECTODOMAIN; COMPND 5 SYNONYM: UL27; COMPND 6 ENGINEERED: YES; COMPND 7 MUTATION: YES; COMPND 8 MOL_ID: 2; COMPND 9 MOLECULE: D48 HEAVY CHAIN; COMPND 10 CHAIN: I, J, K; COMPND 11 ENGINEERED: YES; COMPND 12 MOL_ID: 3; COMPND 13 MOLECULE: D48 LIGHT CHAIN; COMPND 14 CHAIN: M, N, O; COMPND 15 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN ALPHAHERPESVIRUS 1; SOURCE 3 ORGANISM_COMMON: HERPES SIMPLEX VIRUS TYPE 1; SOURCE 4 ORGANISM_TAXID: 10298; SOURCE 5 GENE: UL27; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_TAXID: 9606; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_TAXID: 9606; SOURCE 16 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS IMMUNE COMPLEX, NEUTRALIZATION, HERPES FUSOGEN, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR R.S.ROARK,L.SHAPIRO,P.D.KWONG REVDAT 1 10-SEP-25 9DD7 0 JRNL AUTH R.S.ROARK,L.SHAPIRO,P.D.KWONG JRNL TITL PREFUSION STRUCTURE AND NEUTRALIZATION OF HSV-1 GLYCOPROTEIN JRNL TITL 2 B JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 4.10 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.100 REMARK 3 NUMBER OF PARTICLES : 73388 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9DD7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-AUG-24. REMARK 100 THE DEPOSITION ID IS D_1000287875. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : D48 FAB IN COMPLEX WITH HSV-1 REMARK 245 GB TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1800.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5800.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, G, I, J, K, M, N, O, A, REMARK 350 AND CHAINS: B, C, D, H, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET E 1 REMARK 465 HIS E 2 REMARK 465 GLN E 3 REMARK 465 GLY E 4 REMARK 465 ALA E 5 REMARK 465 PRO E 6 REMARK 465 SER E 7 REMARK 465 TRP E 8 REMARK 465 GLY E 9 REMARK 465 ARG E 10 REMARK 465 ARG E 11 REMARK 465 TRP E 12 REMARK 465 PHE E 13 REMARK 465 VAL E 14 REMARK 465 VAL E 15 REMARK 465 TRP E 16 REMARK 465 ALA E 17 REMARK 465 LEU E 18 REMARK 465 LEU E 19 REMARK 465 GLY E 20 REMARK 465 LEU E 21 REMARK 465 THR E 22 REMARK 465 LEU E 23 REMARK 465 GLY E 24 REMARK 465 VAL E 25 REMARK 465 LEU E 26 REMARK 465 VAL E 27 REMARK 465 ALA E 28 REMARK 465 SER E 29 REMARK 465 ALA E 30 REMARK 465 ALA E 31 REMARK 465 PRO E 32 REMARK 465 SER E 33 REMARK 465 SER E 34 REMARK 465 PRO E 35 REMARK 465 GLY E 36 REMARK 465 THR E 37 REMARK 465 PRO E 38 REMARK 465 GLY E 39 REMARK 465 VAL E 40 REMARK 465 ALA E 41 REMARK 465 ALA E 42 REMARK 465 ALA E 43 REMARK 465 THR E 44 REMARK 465 GLN E 45 REMARK 465 ALA E 46 REMARK 465 ALA E 47 REMARK 465 ASN E 48 REMARK 465 GLY E 49 REMARK 465 GLY E 50 REMARK 465 PRO E 51 REMARK 465 ALA E 52 REMARK 465 THR E 53 REMARK 465 PRO E 54 REMARK 465 ALA E 55 REMARK 465 PRO E 56 REMARK 465 PRO E 57 REMARK 465 ALA E 58 REMARK 465 LEU E 59 REMARK 465 GLY E 60 REMARK 465 ALA E 61 REMARK 465 ALA E 62 REMARK 465 PRO E 63 REMARK 465 THR E 64 REMARK 465 GLY E 65 REMARK 465 ASP E 66 REMARK 465 PRO E 67 REMARK 465 LYS E 68 REMARK 465 PRO E 69 REMARK 465 LYS E 70 REMARK 465 LYS E 71 REMARK 465 ASN E 72 REMARK 465 LYS E 73 REMARK 465 LYS E 74 REMARK 465 PRO E 75 REMARK 465 LYS E 76 REMARK 465 ASN E 77 REMARK 465 PRO E 78 REMARK 465 THR E 79 REMARK 465 PRO E 80 REMARK 465 PRO E 81 REMARK 465 ARG E 82 REMARK 465 PRO E 83 REMARK 465 ALA E 84 REMARK 465 GLY E 85 REMARK 465 ASP E 86 REMARK 465 ASN E 87 REMARK 465 ALA E 88 REMARK 465 THR E 89 REMARK 465 VAL E 90 REMARK 465 ALA E 91 REMARK 465 ALA E 92 REMARK 465 GLY E 93 REMARK 465 HIS E 94 REMARK 465 ALA E 95 REMARK 465 THR E 96 REMARK 465 LEU E 97 REMARK 465 ARG E 98 REMARK 465 GLU E 99 REMARK 465 HIS E 100 REMARK 465 LEU E 101 REMARK 465 ARG E 102 REMARK 465 ASP E 103 REMARK 465 ILE E 104 REMARK 465 LYS E 105 REMARK 465 ALA E 106 REMARK 465 GLU E 107 REMARK 465 ASN E 108 REMARK 465 THR E 109 REMARK 465 TRP E 174 REMARK 465 PHE E 175 REMARK 465 GLY E 176 REMARK 465 HIS E 177 REMARK 465 ARG E 178 REMARK 465 TYR E 179 REMARK 465 SER E 180 REMARK 465 GLN E 181 REMARK 465 PHE E 182 REMARK 465 MET E 183 REMARK 465 GLY E 184 REMARK 465 LEU E 252 REMARK 465 LYS E 253 REMARK 465 TYR E 254 REMARK 465 ASN E 255 REMARK 465 PRO E 256 REMARK 465 SER E 257 REMARK 465 ARG E 258 REMARK 465 VAL E 259 REMARK 465 GLU E 260 REMARK 465 ALA E 261 REMARK 465 PHE E 262 REMARK 465 HIS E 263 REMARK 465 ARG E 264 REMARK 465 TYR E 265 REMARK 465 GLY E 266 REMARK 465 LEU E 460 REMARK 465 ALA E 461 REMARK 465 GLU E 462 REMARK 465 LEU E 463 REMARK 465 TYR E 464 REMARK 465 VAL E 465 REMARK 465 ARG E 466 REMARK 465 GLU E 467 REMARK 465 HIS E 468 REMARK 465 LEU E 469 REMARK 465 ARG E 470 REMARK 465 GLU E 471 REMARK 465 GLN E 472 REMARK 465 SER E 473 REMARK 465 ARG E 474 REMARK 465 LYS E 475 REMARK 465 PRO E 476 REMARK 465 PRO E 477 REMARK 465 ASN E 478 REMARK 465 PRO E 479 REMARK 465 THR E 480 REMARK 465 PRO E 481 REMARK 465 PRO E 482 REMARK 465 PRO E 483 REMARK 465 PRO E 484 REMARK 465 GLY E 485 REMARK 465 ALA E 486 REMARK 465 SER E 487 REMARK 465 ALA E 488 REMARK 465 ASN E 489 REMARK 465 ALA E 490 REMARK 465 SER E 491 REMARK 465 VAL E 492 REMARK 465 GLU E 493 REMARK 465 ARG E 494 REMARK 465 ILE E 495 REMARK 465 LYS E 496 REMARK 465 THR E 497 REMARK 465 THR E 498 REMARK 465 SER E 499 REMARK 465 SER E 500 REMARK 465 ILE E 501 REMARK 465 GLU E 502 REMARK 465 PHE E 503 REMARK 465 ALA E 504 REMARK 465 ARG E 505 REMARK 465 LEU E 506 REMARK 465 GLN E 507 REMARK 465 PHE E 508 REMARK 465 THR E 509 REMARK 465 TYR E 510 REMARK 465 ASN E 511 REMARK 465 ILE E 675 REMARK 465 THR E 676 REMARK 465 MET E 677 REMARK 465 LEU E 678 REMARK 465 GLU E 679 REMARK 465 ASP E 680 REMARK 465 HIS E 681 REMARK 465 GLU E 682 REMARK 465 PHE E 683 REMARK 465 VAL E 684 REMARK 465 PRO E 685 REMARK 465 LEU E 686 REMARK 465 GLU E 687 REMARK 465 VAL E 688 REMARK 465 TYR E 689 REMARK 465 THR E 690 REMARK 465 ARG E 691 REMARK 465 THR E 703 REMARK 465 GLU E 704 REMARK 465 VAL E 705 REMARK 465 GLN E 706 REMARK 465 ARG E 707 REMARK 465 ARG E 708 REMARK 465 ASN E 709 REMARK 465 GLN E 710 REMARK 465 LEU E 711 REMARK 465 HIS E 712 REMARK 465 ASP E 713 REMARK 465 LEU E 714 REMARK 465 ARG E 715 REMARK 465 PHE E 716 REMARK 465 ALA E 717 REMARK 465 ASP E 718 REMARK 465 ILE E 719 REMARK 465 ASP E 720 REMARK 465 THR E 721 REMARK 465 VAL E 722 REMARK 465 ILE E 723 REMARK 465 HIS E 724 REMARK 465 ALA E 725 REMARK 465 ASP E 726 REMARK 465 ALA E 727 REMARK 465 ASN E 728 REMARK 465 GLY E 729 REMARK 465 SER E 730 REMARK 465 GLY E 731 REMARK 465 TYR E 732 REMARK 465 ILE E 733 REMARK 465 PRO E 734 REMARK 465 GLU E 735 REMARK 465 ALA E 736 REMARK 465 PRO E 737 REMARK 465 ARG E 738 REMARK 465 ASP E 739 REMARK 465 GLY E 740 REMARK 465 GLN E 741 REMARK 465 ALA E 742 REMARK 465 TYR E 743 REMARK 465 VAL E 744 REMARK 465 ARG E 745 REMARK 465 LYS E 746 REMARK 465 ASP E 747 REMARK 465 GLY E 748 REMARK 465 GLU E 749 REMARK 465 TRP E 750 REMARK 465 VAL E 751 REMARK 465 LEU E 752 REMARK 465 LEU E 753 REMARK 465 SER E 754 REMARK 465 THR E 755 REMARK 465 PHE E 756 REMARK 465 LEU E 757 REMARK 465 GLY E 758 REMARK 465 ARG E 759 REMARK 465 SER E 760 REMARK 465 LEU E 761 REMARK 465 GLU E 762 REMARK 465 VAL E 763 REMARK 465 LEU E 764 REMARK 465 PHE E 765 REMARK 465 GLN E 766 REMARK 465 GLY E 767 REMARK 465 PRO E 768 REMARK 465 GLY E 769 REMARK 465 HIS E 770 REMARK 465 HIS E 771 REMARK 465 HIS E 772 REMARK 465 HIS E 773 REMARK 465 HIS E 774 REMARK 465 HIS E 775 REMARK 465 HIS E 776 REMARK 465 HIS E 777 REMARK 465 SER E 778 REMARK 465 ALA E 779 REMARK 465 TRP E 780 REMARK 465 SER E 781 REMARK 465 HIS E 782 REMARK 465 PRO E 783 REMARK 465 GLN E 784 REMARK 465 PHE E 785 REMARK 465 GLU E 786 REMARK 465 LYS E 787 REMARK 465 GLY E 788 REMARK 465 GLY E 789 REMARK 465 GLY E 790 REMARK 465 SER E 791 REMARK 465 GLY E 792 REMARK 465 GLY E 793 REMARK 465 GLY E 794 REMARK 465 GLY E 795 REMARK 465 SER E 796 REMARK 465 GLY E 797 REMARK 465 GLY E 798 REMARK 465 SER E 799 REMARK 465 ALA E 800 REMARK 465 TRP E 801 REMARK 465 SER E 802 REMARK 465 HIS E 803 REMARK 465 PRO E 804 REMARK 465 GLN E 805 REMARK 465 PHE E 806 REMARK 465 GLU E 807 REMARK 465 LYS E 808 REMARK 465 MET F 1 REMARK 465 HIS F 2 REMARK 465 GLN F 3 REMARK 465 GLY F 4 REMARK 465 ALA F 5 REMARK 465 PRO F 6 REMARK 465 SER F 7 REMARK 465 TRP F 8 REMARK 465 GLY F 9 REMARK 465 ARG F 10 REMARK 465 ARG F 11 REMARK 465 TRP F 12 REMARK 465 PHE F 13 REMARK 465 VAL F 14 REMARK 465 VAL F 15 REMARK 465 TRP F 16 REMARK 465 ALA F 17 REMARK 465 LEU F 18 REMARK 465 LEU F 19 REMARK 465 GLY F 20 REMARK 465 LEU F 21 REMARK 465 THR F 22 REMARK 465 LEU F 23 REMARK 465 GLY F 24 REMARK 465 VAL F 25 REMARK 465 LEU F 26 REMARK 465 VAL F 27 REMARK 465 ALA F 28 REMARK 465 SER F 29 REMARK 465 ALA F 30 REMARK 465 ALA F 31 REMARK 465 PRO F 32 REMARK 465 SER F 33 REMARK 465 SER F 34 REMARK 465 PRO F 35 REMARK 465 GLY F 36 REMARK 465 THR F 37 REMARK 465 PRO F 38 REMARK 465 GLY F 39 REMARK 465 VAL F 40 REMARK 465 ALA F 41 REMARK 465 ALA F 42 REMARK 465 ALA F 43 REMARK 465 THR F 44 REMARK 465 GLN F 45 REMARK 465 ALA F 46 REMARK 465 ALA F 47 REMARK 465 ASN F 48 REMARK 465 GLY F 49 REMARK 465 GLY F 50 REMARK 465 PRO F 51 REMARK 465 ALA F 52 REMARK 465 THR F 53 REMARK 465 PRO F 54 REMARK 465 ALA F 55 REMARK 465 PRO F 56 REMARK 465 PRO F 57 REMARK 465 ALA F 58 REMARK 465 LEU F 59 REMARK 465 GLY F 60 REMARK 465 ALA F 61 REMARK 465 ALA F 62 REMARK 465 PRO F 63 REMARK 465 THR F 64 REMARK 465 GLY F 65 REMARK 465 ASP F 66 REMARK 465 PRO F 67 REMARK 465 LYS F 68 REMARK 465 PRO F 69 REMARK 465 LYS F 70 REMARK 465 LYS F 71 REMARK 465 ASN F 72 REMARK 465 LYS F 73 REMARK 465 LYS F 74 REMARK 465 PRO F 75 REMARK 465 LYS F 76 REMARK 465 ASN F 77 REMARK 465 PRO F 78 REMARK 465 THR F 79 REMARK 465 PRO F 80 REMARK 465 PRO F 81 REMARK 465 ARG F 82 REMARK 465 PRO F 83 REMARK 465 ALA F 84 REMARK 465 GLY F 85 REMARK 465 ASP F 86 REMARK 465 ASN F 87 REMARK 465 ALA F 88 REMARK 465 THR F 89 REMARK 465 VAL F 90 REMARK 465 ALA F 91 REMARK 465 ALA F 92 REMARK 465 GLY F 93 REMARK 465 HIS F 94 REMARK 465 ALA F 95 REMARK 465 THR F 96 REMARK 465 LEU F 97 REMARK 465 ARG F 98 REMARK 465 GLU F 99 REMARK 465 HIS F 100 REMARK 465 LEU F 101 REMARK 465 ARG F 102 REMARK 465 ASP F 103 REMARK 465 ILE F 104 REMARK 465 LYS F 105 REMARK 465 ALA F 106 REMARK 465 GLU F 107 REMARK 465 ASN F 108 REMARK 465 THR F 109 REMARK 465 TRP F 174 REMARK 465 PHE F 175 REMARK 465 GLY F 176 REMARK 465 HIS F 177 REMARK 465 ARG F 178 REMARK 465 TYR F 179 REMARK 465 SER F 180 REMARK 465 GLN F 181 REMARK 465 PHE F 182 REMARK 465 MET F 183 REMARK 465 GLY F 184 REMARK 465 LEU F 252 REMARK 465 LYS F 253 REMARK 465 TYR F 254 REMARK 465 ASN F 255 REMARK 465 PRO F 256 REMARK 465 SER F 257 REMARK 465 ARG F 258 REMARK 465 VAL F 259 REMARK 465 GLU F 260 REMARK 465 ALA F 261 REMARK 465 PHE F 262 REMARK 465 HIS F 263 REMARK 465 ARG F 264 REMARK 465 TYR F 265 REMARK 465 GLY F 266 REMARK 465 LEU F 460 REMARK 465 ALA F 461 REMARK 465 GLU F 462 REMARK 465 LEU F 463 REMARK 465 TYR F 464 REMARK 465 VAL F 465 REMARK 465 ARG F 466 REMARK 465 GLU F 467 REMARK 465 HIS F 468 REMARK 465 LEU F 469 REMARK 465 ARG F 470 REMARK 465 GLU F 471 REMARK 465 GLN F 472 REMARK 465 SER F 473 REMARK 465 ARG F 474 REMARK 465 LYS F 475 REMARK 465 PRO F 476 REMARK 465 PRO F 477 REMARK 465 ASN F 478 REMARK 465 PRO F 479 REMARK 465 THR F 480 REMARK 465 PRO F 481 REMARK 465 PRO F 482 REMARK 465 PRO F 483 REMARK 465 PRO F 484 REMARK 465 GLY F 485 REMARK 465 ALA F 486 REMARK 465 SER F 487 REMARK 465 ALA F 488 REMARK 465 ASN F 489 REMARK 465 ALA F 490 REMARK 465 SER F 491 REMARK 465 VAL F 492 REMARK 465 GLU F 493 REMARK 465 ARG F 494 REMARK 465 ILE F 495 REMARK 465 LYS F 496 REMARK 465 THR F 497 REMARK 465 THR F 498 REMARK 465 SER F 499 REMARK 465 SER F 500 REMARK 465 ILE F 501 REMARK 465 GLU F 502 REMARK 465 PHE F 503 REMARK 465 ALA F 504 REMARK 465 ARG F 505 REMARK 465 LEU F 506 REMARK 465 GLN F 507 REMARK 465 PHE F 508 REMARK 465 THR F 509 REMARK 465 TYR F 510 REMARK 465 ASN F 511 REMARK 465 ILE F 675 REMARK 465 THR F 676 REMARK 465 MET F 677 REMARK 465 LEU F 678 REMARK 465 GLU F 679 REMARK 465 ASP F 680 REMARK 465 HIS F 681 REMARK 465 GLU F 682 REMARK 465 PHE F 683 REMARK 465 VAL F 684 REMARK 465 PRO F 685 REMARK 465 LEU F 686 REMARK 465 GLU F 687 REMARK 465 VAL F 688 REMARK 465 TYR F 689 REMARK 465 THR F 690 REMARK 465 ARG F 691 REMARK 465 THR F 703 REMARK 465 GLU F 704 REMARK 465 VAL F 705 REMARK 465 GLN F 706 REMARK 465 ARG F 707 REMARK 465 ARG F 708 REMARK 465 ASN F 709 REMARK 465 GLN F 710 REMARK 465 LEU F 711 REMARK 465 HIS F 712 REMARK 465 ASP F 713 REMARK 465 LEU F 714 REMARK 465 ARG F 715 REMARK 465 PHE F 716 REMARK 465 ALA F 717 REMARK 465 ASP F 718 REMARK 465 ILE F 719 REMARK 465 ASP F 720 REMARK 465 THR F 721 REMARK 465 VAL F 722 REMARK 465 ILE F 723 REMARK 465 HIS F 724 REMARK 465 ALA F 725 REMARK 465 ASP F 726 REMARK 465 ALA F 727 REMARK 465 ASN F 728 REMARK 465 GLY F 729 REMARK 465 SER F 730 REMARK 465 GLY F 731 REMARK 465 TYR F 732 REMARK 465 ILE F 733 REMARK 465 PRO F 734 REMARK 465 GLU F 735 REMARK 465 ALA F 736 REMARK 465 PRO F 737 REMARK 465 ARG F 738 REMARK 465 ASP F 739 REMARK 465 GLY F 740 REMARK 465 GLN F 741 REMARK 465 ALA F 742 REMARK 465 TYR F 743 REMARK 465 VAL F 744 REMARK 465 ARG F 745 REMARK 465 LYS F 746 REMARK 465 ASP F 747 REMARK 465 GLY F 748 REMARK 465 GLU F 749 REMARK 465 TRP F 750 REMARK 465 VAL F 751 REMARK 465 LEU F 752 REMARK 465 LEU F 753 REMARK 465 SER F 754 REMARK 465 THR F 755 REMARK 465 PHE F 756 REMARK 465 LEU F 757 REMARK 465 GLY F 758 REMARK 465 ARG F 759 REMARK 465 SER F 760 REMARK 465 LEU F 761 REMARK 465 GLU F 762 REMARK 465 VAL F 763 REMARK 465 LEU F 764 REMARK 465 PHE F 765 REMARK 465 GLN F 766 REMARK 465 GLY F 767 REMARK 465 PRO F 768 REMARK 465 GLY F 769 REMARK 465 HIS F 770 REMARK 465 HIS F 771 REMARK 465 HIS F 772 REMARK 465 HIS F 773 REMARK 465 HIS F 774 REMARK 465 HIS F 775 REMARK 465 HIS F 776 REMARK 465 HIS F 777 REMARK 465 SER F 778 REMARK 465 ALA F 779 REMARK 465 TRP F 780 REMARK 465 SER F 781 REMARK 465 HIS F 782 REMARK 465 PRO F 783 REMARK 465 GLN F 784 REMARK 465 PHE F 785 REMARK 465 GLU F 786 REMARK 465 LYS F 787 REMARK 465 GLY F 788 REMARK 465 GLY F 789 REMARK 465 GLY F 790 REMARK 465 SER F 791 REMARK 465 GLY F 792 REMARK 465 GLY F 793 REMARK 465 GLY F 794 REMARK 465 GLY F 795 REMARK 465 SER F 796 REMARK 465 GLY F 797 REMARK 465 GLY F 798 REMARK 465 SER F 799 REMARK 465 ALA F 800 REMARK 465 TRP F 801 REMARK 465 SER F 802 REMARK 465 HIS F 803 REMARK 465 PRO F 804 REMARK 465 GLN F 805 REMARK 465 PHE F 806 REMARK 465 GLU F 807 REMARK 465 LYS F 808 REMARK 465 MET G 1 REMARK 465 HIS G 2 REMARK 465 GLN G 3 REMARK 465 GLY G 4 REMARK 465 ALA G 5 REMARK 465 PRO G 6 REMARK 465 SER G 7 REMARK 465 TRP G 8 REMARK 465 GLY G 9 REMARK 465 ARG G 10 REMARK 465 ARG G 11 REMARK 465 TRP G 12 REMARK 465 PHE G 13 REMARK 465 VAL G 14 REMARK 465 VAL G 15 REMARK 465 TRP G 16 REMARK 465 ALA G 17 REMARK 465 LEU G 18 REMARK 465 LEU G 19 REMARK 465 GLY G 20 REMARK 465 LEU G 21 REMARK 465 THR G 22 REMARK 465 LEU G 23 REMARK 465 GLY G 24 REMARK 465 VAL G 25 REMARK 465 LEU G 26 REMARK 465 VAL G 27 REMARK 465 ALA G 28 REMARK 465 SER G 29 REMARK 465 ALA G 30 REMARK 465 ALA G 31 REMARK 465 PRO G 32 REMARK 465 SER G 33 REMARK 465 SER G 34 REMARK 465 PRO G 35 REMARK 465 GLY G 36 REMARK 465 THR G 37 REMARK 465 PRO G 38 REMARK 465 GLY G 39 REMARK 465 VAL G 40 REMARK 465 ALA G 41 REMARK 465 ALA G 42 REMARK 465 ALA G 43 REMARK 465 THR G 44 REMARK 465 GLN G 45 REMARK 465 ALA G 46 REMARK 465 ALA G 47 REMARK 465 ASN G 48 REMARK 465 GLY G 49 REMARK 465 GLY G 50 REMARK 465 PRO G 51 REMARK 465 ALA G 52 REMARK 465 THR G 53 REMARK 465 PRO G 54 REMARK 465 ALA G 55 REMARK 465 PRO G 56 REMARK 465 PRO G 57 REMARK 465 ALA G 58 REMARK 465 LEU G 59 REMARK 465 GLY G 60 REMARK 465 ALA G 61 REMARK 465 ALA G 62 REMARK 465 PRO G 63 REMARK 465 THR G 64 REMARK 465 GLY G 65 REMARK 465 ASP G 66 REMARK 465 PRO G 67 REMARK 465 LYS G 68 REMARK 465 PRO G 69 REMARK 465 LYS G 70 REMARK 465 LYS G 71 REMARK 465 ASN G 72 REMARK 465 LYS G 73 REMARK 465 LYS G 74 REMARK 465 PRO G 75 REMARK 465 LYS G 76 REMARK 465 ASN G 77 REMARK 465 PRO G 78 REMARK 465 THR G 79 REMARK 465 PRO G 80 REMARK 465 PRO G 81 REMARK 465 ARG G 82 REMARK 465 PRO G 83 REMARK 465 ALA G 84 REMARK 465 GLY G 85 REMARK 465 ASP G 86 REMARK 465 ASN G 87 REMARK 465 ALA G 88 REMARK 465 THR G 89 REMARK 465 VAL G 90 REMARK 465 ALA G 91 REMARK 465 ALA G 92 REMARK 465 GLY G 93 REMARK 465 HIS G 94 REMARK 465 ALA G 95 REMARK 465 THR G 96 REMARK 465 LEU G 97 REMARK 465 ARG G 98 REMARK 465 GLU G 99 REMARK 465 HIS G 100 REMARK 465 LEU G 101 REMARK 465 ARG G 102 REMARK 465 ASP G 103 REMARK 465 ILE G 104 REMARK 465 LYS G 105 REMARK 465 ALA G 106 REMARK 465 GLU G 107 REMARK 465 ASN G 108 REMARK 465 THR G 109 REMARK 465 TRP G 174 REMARK 465 PHE G 175 REMARK 465 GLY G 176 REMARK 465 HIS G 177 REMARK 465 ARG G 178 REMARK 465 TYR G 179 REMARK 465 SER G 180 REMARK 465 GLN G 181 REMARK 465 PHE G 182 REMARK 465 MET G 183 REMARK 465 GLY G 184 REMARK 465 LEU G 252 REMARK 465 LYS G 253 REMARK 465 TYR G 254 REMARK 465 ASN G 255 REMARK 465 PRO G 256 REMARK 465 SER G 257 REMARK 465 ARG G 258 REMARK 465 VAL G 259 REMARK 465 GLU G 260 REMARK 465 ALA G 261 REMARK 465 PHE G 262 REMARK 465 HIS G 263 REMARK 465 ARG G 264 REMARK 465 TYR G 265 REMARK 465 GLY G 266 REMARK 465 LEU G 460 REMARK 465 ALA G 461 REMARK 465 GLU G 462 REMARK 465 LEU G 463 REMARK 465 TYR G 464 REMARK 465 VAL G 465 REMARK 465 ARG G 466 REMARK 465 GLU G 467 REMARK 465 HIS G 468 REMARK 465 LEU G 469 REMARK 465 ARG G 470 REMARK 465 GLU G 471 REMARK 465 GLN G 472 REMARK 465 SER G 473 REMARK 465 ARG G 474 REMARK 465 LYS G 475 REMARK 465 PRO G 476 REMARK 465 PRO G 477 REMARK 465 ASN G 478 REMARK 465 PRO G 479 REMARK 465 THR G 480 REMARK 465 PRO G 481 REMARK 465 PRO G 482 REMARK 465 PRO G 483 REMARK 465 PRO G 484 REMARK 465 GLY G 485 REMARK 465 ALA G 486 REMARK 465 SER G 487 REMARK 465 ALA G 488 REMARK 465 ASN G 489 REMARK 465 ALA G 490 REMARK 465 SER G 491 REMARK 465 VAL G 492 REMARK 465 GLU G 493 REMARK 465 ARG G 494 REMARK 465 ILE G 495 REMARK 465 LYS G 496 REMARK 465 THR G 497 REMARK 465 THR G 498 REMARK 465 SER G 499 REMARK 465 SER G 500 REMARK 465 ILE G 501 REMARK 465 GLU G 502 REMARK 465 PHE G 503 REMARK 465 ALA G 504 REMARK 465 ARG G 505 REMARK 465 LEU G 506 REMARK 465 GLN G 507 REMARK 465 PHE G 508 REMARK 465 THR G 509 REMARK 465 TYR G 510 REMARK 465 ASN G 511 REMARK 465 ILE G 675 REMARK 465 THR G 676 REMARK 465 MET G 677 REMARK 465 LEU G 678 REMARK 465 GLU G 679 REMARK 465 ASP G 680 REMARK 465 HIS G 681 REMARK 465 GLU G 682 REMARK 465 PHE G 683 REMARK 465 VAL G 684 REMARK 465 PRO G 685 REMARK 465 LEU G 686 REMARK 465 GLU G 687 REMARK 465 VAL G 688 REMARK 465 TYR G 689 REMARK 465 THR G 690 REMARK 465 ARG G 691 REMARK 465 THR G 703 REMARK 465 GLU G 704 REMARK 465 VAL G 705 REMARK 465 GLN G 706 REMARK 465 ARG G 707 REMARK 465 ARG G 708 REMARK 465 ASN G 709 REMARK 465 GLN G 710 REMARK 465 LEU G 711 REMARK 465 HIS G 712 REMARK 465 ASP G 713 REMARK 465 LEU G 714 REMARK 465 ARG G 715 REMARK 465 PHE G 716 REMARK 465 ALA G 717 REMARK 465 ASP G 718 REMARK 465 ILE G 719 REMARK 465 ASP G 720 REMARK 465 THR G 721 REMARK 465 VAL G 722 REMARK 465 ILE G 723 REMARK 465 HIS G 724 REMARK 465 ALA G 725 REMARK 465 ASP G 726 REMARK 465 ALA G 727 REMARK 465 ASN G 728 REMARK 465 GLY G 729 REMARK 465 SER G 730 REMARK 465 GLY G 731 REMARK 465 TYR G 732 REMARK 465 ILE G 733 REMARK 465 PRO G 734 REMARK 465 GLU G 735 REMARK 465 ALA G 736 REMARK 465 PRO G 737 REMARK 465 ARG G 738 REMARK 465 ASP G 739 REMARK 465 GLY G 740 REMARK 465 GLN G 741 REMARK 465 ALA G 742 REMARK 465 TYR G 743 REMARK 465 VAL G 744 REMARK 465 ARG G 745 REMARK 465 LYS G 746 REMARK 465 ASP G 747 REMARK 465 GLY G 748 REMARK 465 GLU G 749 REMARK 465 TRP G 750 REMARK 465 VAL G 751 REMARK 465 LEU G 752 REMARK 465 LEU G 753 REMARK 465 SER G 754 REMARK 465 THR G 755 REMARK 465 PHE G 756 REMARK 465 LEU G 757 REMARK 465 GLY G 758 REMARK 465 ARG G 759 REMARK 465 SER G 760 REMARK 465 LEU G 761 REMARK 465 GLU G 762 REMARK 465 VAL G 763 REMARK 465 LEU G 764 REMARK 465 PHE G 765 REMARK 465 GLN G 766 REMARK 465 GLY G 767 REMARK 465 PRO G 768 REMARK 465 GLY G 769 REMARK 465 HIS G 770 REMARK 465 HIS G 771 REMARK 465 HIS G 772 REMARK 465 HIS G 773 REMARK 465 HIS G 774 REMARK 465 HIS G 775 REMARK 465 HIS G 776 REMARK 465 HIS G 777 REMARK 465 SER G 778 REMARK 465 ALA G 779 REMARK 465 TRP G 780 REMARK 465 SER G 781 REMARK 465 HIS G 782 REMARK 465 PRO G 783 REMARK 465 GLN G 784 REMARK 465 PHE G 785 REMARK 465 GLU G 786 REMARK 465 LYS G 787 REMARK 465 GLY G 788 REMARK 465 GLY G 789 REMARK 465 GLY G 790 REMARK 465 SER G 791 REMARK 465 GLY G 792 REMARK 465 GLY G 793 REMARK 465 GLY G 794 REMARK 465 GLY G 795 REMARK 465 SER G 796 REMARK 465 GLY G 797 REMARK 465 GLY G 798 REMARK 465 SER G 799 REMARK 465 ALA G 800 REMARK 465 TRP G 801 REMARK 465 SER G 802 REMARK 465 HIS G 803 REMARK 465 PRO G 804 REMARK 465 GLN G 805 REMARK 465 PHE G 806 REMARK 465 GLU G 807 REMARK 465 LYS G 808 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG1 THR E 249 OD1 ASN E 270 2.10 REMARK 500 OE1 GLN E 440 OH TYR E 442 2.14 REMARK 500 OG SER I 52 OD1 ASP I 53 2.15 REMARK 500 OG1 THR G 249 OD1 ASN G 270 2.17 REMARK 500 OG1 THR E 143 O ARG E 377 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS E 633 CA - CB - SG ANGL. DEV. = 7.8 DEGREES REMARK 500 CYS F 633 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLN E 129 165.32 65.78 REMARK 500 PRO E 137 49.39 -87.11 REMARK 500 GLU E 138 -152.75 60.01 REMARK 500 ALA E 239 -11.09 77.15 REMARK 500 CYS E 240 134.69 -176.49 REMARK 500 THR E 243 -157.85 -148.63 REMARK 500 THR E 312 130.87 -170.02 REMARK 500 ARG E 335 159.12 67.45 REMARK 500 SER E 388 -160.70 -117.95 REMARK 500 LEU E 399 -5.79 76.84 REMARK 500 ASP E 408 -0.53 79.63 REMARK 500 LEU E 564 55.57 -93.13 REMARK 500 PRO E 632 80.65 -68.91 REMARK 500 ARG E 638 109.62 -160.41 REMARK 500 THR E 669 47.12 -97.20 REMARK 500 LYS E 695 -166.91 -160.91 REMARK 500 ASP E 696 145.34 79.24 REMARK 500 GLN F 129 164.73 64.49 REMARK 500 GLU F 138 -158.75 60.51 REMARK 500 ASP F 199 -60.97 -96.12 REMARK 500 ASN F 217 31.96 71.56 REMARK 500 ALA F 239 -11.34 77.31 REMARK 500 CYS F 240 134.28 -175.88 REMARK 500 THR F 243 -157.98 -148.51 REMARK 500 MET F 297 143.79 -173.44 REMARK 500 ALA F 327 65.11 39.68 REMARK 500 ARG F 335 165.25 68.07 REMARK 500 SER F 388 -156.93 -92.22 REMARK 500 ASP F 389 154.40 -45.35 REMARK 500 ASP F 408 -3.45 79.82 REMARK 500 LEU F 564 58.42 -94.35 REMARK 500 PRO F 632 79.58 -69.92 REMARK 500 ARG F 638 110.34 -160.69 REMARK 500 TYR F 653 60.37 60.20 REMARK 500 LYS F 695 -167.01 -161.46 REMARK 500 ASP F 696 146.62 79.53 REMARK 500 GLN G 129 166.34 68.38 REMARK 500 PRO G 137 48.53 -87.89 REMARK 500 GLU G 138 -151.83 59.73 REMARK 500 ASP G 199 -62.78 -90.61 REMARK 500 ASN G 217 31.24 70.48 REMARK 500 ALA G 239 -11.22 76.88 REMARK 500 CYS G 240 130.92 -175.77 REMARK 500 THR G 243 -157.82 -148.47 REMARK 500 ALA G 327 71.48 42.62 REMARK 500 ARG G 335 152.93 68.42 REMARK 500 ALA G 336 -175.81 -69.98 REMARK 500 SER G 388 -161.91 -118.15 REMARK 500 ASP G 408 -1.58 80.11 REMARK 500 ARG G 428 -30.07 -132.88 REMARK 500 REMARK 500 THIS ENTRY HAS 70 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-46759 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF NEUTRALIZING HUMAN ANTIBODY D48 IN COMPLEX REMARK 900 WITH HSV-1 GLYCOPROTEIN B TRIMER GB-ECTO.516P.531E.DS DBREF 9DD7 E 1 728 UNP A1Z0P6 A1Z0P6_HHV1 1 728 DBREF 9DD7 F 1 728 UNP A1Z0P6 A1Z0P6_HHV1 1 728 DBREF 9DD7 G 1 728 UNP A1Z0P6 A1Z0P6_HHV1 1 728 DBREF 9DD7 I 2 110 PDB 9DD7 9DD7 2 110 DBREF 9DD7 J 2 110 PDB 9DD7 9DD7 2 110 DBREF 9DD7 K 2 110 PDB 9DD7 9DD7 2 110 DBREF 9DD7 M 1 107 PDB 9DD7 9DD7 1 107 DBREF 9DD7 N 1 107 PDB 9DD7 9DD7 1 107 DBREF 9DD7 O 1 107 PDB 9DD7 9DD7 1 107 SEQADV 9DD7 CYS E 240 UNP A1Z0P6 ALA 240 CONFLICT SEQADV 9DD7 PRO E 516 UNP A1Z0P6 HIS 516 ENGINEERED MUTATION SEQADV 9DD7 GLU E 531 UNP A1Z0P6 LEU 531 ENGINEERED MUTATION SEQADV 9DD7 CYS E 607 UNP A1Z0P6 GLU 607 CONFLICT SEQADV 9DD7 GLY E 729 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 730 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 731 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TYR E 732 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ILE E 733 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO E 734 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU E 735 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA E 736 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO E 737 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG E 738 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ASP E 739 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 740 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN E 741 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA E 742 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TYR E 743 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL E 744 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG E 745 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS E 746 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ASP E 747 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 748 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU E 749 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP E 750 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL E 751 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU E 752 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU E 753 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 754 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 THR E 755 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE E 756 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU E 757 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 758 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG E 759 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 760 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU E 761 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU E 762 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL E 763 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU E 764 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE E 765 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN E 766 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 767 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO E 768 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 769 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 770 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 771 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 772 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 773 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 774 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 775 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 776 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 777 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 778 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA E 779 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP E 780 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 781 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 782 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO E 783 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN E 784 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE E 785 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU E 786 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS E 787 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 788 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 789 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 790 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 791 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 792 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 793 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 794 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 795 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 796 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 797 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY E 798 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 799 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA E 800 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP E 801 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER E 802 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS E 803 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO E 804 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN E 805 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE E 806 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU E 807 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS E 808 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 CYS F 240 UNP A1Z0P6 ALA 240 CONFLICT SEQADV 9DD7 PRO F 516 UNP A1Z0P6 HIS 516 ENGINEERED MUTATION SEQADV 9DD7 GLU F 531 UNP A1Z0P6 LEU 531 ENGINEERED MUTATION SEQADV 9DD7 CYS F 607 UNP A1Z0P6 GLU 607 CONFLICT SEQADV 9DD7 GLY F 729 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 730 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 731 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TYR F 732 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ILE F 733 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO F 734 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU F 735 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA F 736 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO F 737 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG F 738 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ASP F 739 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 740 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN F 741 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA F 742 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TYR F 743 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL F 744 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG F 745 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS F 746 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ASP F 747 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 748 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU F 749 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP F 750 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL F 751 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU F 752 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU F 753 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 754 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 THR F 755 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE F 756 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU F 757 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 758 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG F 759 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 760 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU F 761 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU F 762 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL F 763 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU F 764 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE F 765 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN F 766 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 767 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO F 768 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 769 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 770 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 771 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 772 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 773 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 774 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 775 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 776 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 777 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 778 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA F 779 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP F 780 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 781 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 782 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO F 783 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN F 784 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE F 785 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU F 786 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS F 787 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 788 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 789 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 790 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 791 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 792 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 793 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 794 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 795 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 796 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 797 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY F 798 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 799 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA F 800 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP F 801 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER F 802 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS F 803 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO F 804 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN F 805 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE F 806 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU F 807 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS F 808 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 CYS G 240 UNP A1Z0P6 ALA 240 CONFLICT SEQADV 9DD7 PRO G 516 UNP A1Z0P6 HIS 516 ENGINEERED MUTATION SEQADV 9DD7 GLU G 531 UNP A1Z0P6 LEU 531 ENGINEERED MUTATION SEQADV 9DD7 CYS G 607 UNP A1Z0P6 GLU 607 CONFLICT SEQADV 9DD7 GLY G 729 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 730 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 731 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TYR G 732 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ILE G 733 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO G 734 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU G 735 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA G 736 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO G 737 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG G 738 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ASP G 739 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 740 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN G 741 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA G 742 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TYR G 743 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL G 744 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG G 745 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS G 746 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ASP G 747 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 748 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU G 749 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP G 750 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL G 751 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU G 752 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU G 753 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 754 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 THR G 755 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE G 756 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU G 757 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 758 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ARG G 759 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 760 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU G 761 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU G 762 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 VAL G 763 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LEU G 764 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE G 765 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN G 766 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 767 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO G 768 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 769 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 770 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 771 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 772 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 773 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 774 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 775 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 776 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 777 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 778 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA G 779 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP G 780 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 781 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 782 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO G 783 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN G 784 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE G 785 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU G 786 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS G 787 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 788 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 789 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 790 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 791 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 792 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 793 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 794 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 795 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 796 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 797 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLY G 798 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 799 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 ALA G 800 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 TRP G 801 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 SER G 802 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 HIS G 803 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PRO G 804 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLN G 805 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 PHE G 806 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 GLU G 807 UNP A1Z0P6 EXPRESSION TAG SEQADV 9DD7 LYS G 808 UNP A1Z0P6 EXPRESSION TAG SEQRES 1 E 808 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 E 808 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 E 808 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 E 808 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 E 808 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 E 808 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 E 808 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 E 808 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 E 808 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 E 808 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 E 808 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 E 808 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 E 808 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 E 808 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 E 808 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 E 808 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 E 808 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 E 808 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 E 808 LYS PRO ALA ASN ALA CYS THR ARG THR SER ARG GLY TRP SEQRES 20 E 808 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 E 808 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 E 808 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 E 808 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 E 808 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 E 808 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 E 808 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 E 808 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 E 808 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 E 808 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 E 808 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 E 808 ILE SER THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 E 808 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 E 808 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 E 808 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 E 808 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 E 808 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 E 808 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 E 808 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 E 808 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 E 808 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 E 808 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU GLU GLN ASN SEQRES 42 E 808 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 E 808 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 E 808 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 E 808 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 E 808 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 E 808 ARG PRO LEU VAL SER PHE ARG TYR CYS ASP GLN GLY PRO SEQRES 48 E 808 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 E 808 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 E 808 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 E 808 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 E 808 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 E 808 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 E 808 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 E 808 THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU ARG SEQRES 56 E 808 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 E 808 GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN SEQRES 58 E 808 ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER SEQRES 59 E 808 THR PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY SEQRES 60 E 808 PRO GLY HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SEQRES 61 E 808 SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY SEQRES 62 E 808 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 63 E 808 GLU LYS SEQRES 1 F 808 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 F 808 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 F 808 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 F 808 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 F 808 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 F 808 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 F 808 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 F 808 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 F 808 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 F 808 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 F 808 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 F 808 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 F 808 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 F 808 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 F 808 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 F 808 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 F 808 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 F 808 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 F 808 LYS PRO ALA ASN ALA CYS THR ARG THR SER ARG GLY TRP SEQRES 20 F 808 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 F 808 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 F 808 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 F 808 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 F 808 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 F 808 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 F 808 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 F 808 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 F 808 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 F 808 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 F 808 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 F 808 ILE SER THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 F 808 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 F 808 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 F 808 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 F 808 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 F 808 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 F 808 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 F 808 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 F 808 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 F 808 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 F 808 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU GLU GLN ASN SEQRES 42 F 808 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 F 808 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 F 808 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 F 808 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 F 808 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 F 808 ARG PRO LEU VAL SER PHE ARG TYR CYS ASP GLN GLY PRO SEQRES 48 F 808 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 F 808 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 F 808 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 F 808 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 F 808 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 F 808 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 F 808 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 F 808 THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU ARG SEQRES 56 F 808 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 F 808 GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN SEQRES 58 F 808 ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER SEQRES 59 F 808 THR PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY SEQRES 60 F 808 PRO GLY HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SEQRES 61 F 808 SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY SEQRES 62 F 808 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 63 F 808 GLU LYS SEQRES 1 G 808 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 G 808 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 G 808 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 G 808 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 G 808 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 G 808 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 G 808 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 G 808 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 G 808 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 G 808 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 G 808 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 G 808 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 G 808 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 G 808 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 G 808 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 G 808 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 G 808 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 G 808 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 G 808 LYS PRO ALA ASN ALA CYS THR ARG THR SER ARG GLY TRP SEQRES 20 G 808 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 G 808 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 G 808 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 G 808 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 G 808 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 G 808 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 G 808 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 G 808 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 G 808 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 G 808 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 G 808 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 G 808 ILE SER THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 G 808 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 G 808 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 G 808 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 G 808 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 G 808 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 G 808 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 G 808 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 G 808 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 G 808 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 G 808 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU GLU GLN ASN SEQRES 42 G 808 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 G 808 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 G 808 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 G 808 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 G 808 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 G 808 ARG PRO LEU VAL SER PHE ARG TYR CYS ASP GLN GLY PRO SEQRES 48 G 808 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 G 808 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 G 808 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 G 808 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 G 808 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 G 808 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 G 808 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 G 808 THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU ARG SEQRES 56 G 808 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 G 808 GLY SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN SEQRES 58 G 808 ALA TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER SEQRES 59 G 808 THR PHE LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY SEQRES 60 G 808 PRO GLY HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SEQRES 61 G 808 SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY SEQRES 62 G 808 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 63 G 808 GLU LYS SEQRES 1 I 120 VAL GLN LEU VAL GLU THR GLY GLY GLY VAL VAL ARG PRO SEQRES 2 I 120 GLY ARG SER LEU ARG LEU SER CYS THR THR SER GLY PHE SEQRES 3 I 120 SER PHE SER GLY SER ALA MET HIS TRP VAL ARG GLN ALA SEQRES 4 I 120 PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER HIS SEQRES 5 I 120 ASP GLY ASN ILE ILE GLN TYR HIS ASP SER VAL LYS GLY SEQRES 6 I 120 ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN VAL LEU SEQRES 7 I 120 LEU LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR ALA SEQRES 8 I 120 MET TYR TYR CYS ALA ARG ASP VAL TRP LEU LEU PRO ALA SEQRES 9 I 120 THR ILE SER TYR ALA PHE ASP PHE TRP GLY GLN GLY THR SEQRES 10 I 120 MET VAL THR SEQRES 1 J 120 VAL GLN LEU VAL GLU THR GLY GLY GLY VAL VAL ARG PRO SEQRES 2 J 120 GLY ARG SER LEU ARG LEU SER CYS THR THR SER GLY PHE SEQRES 3 J 120 SER PHE SER GLY SER ALA MET HIS TRP VAL ARG GLN ALA SEQRES 4 J 120 PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER HIS SEQRES 5 J 120 ASP GLY ASN ILE ILE GLN TYR HIS ASP SER VAL LYS GLY SEQRES 6 J 120 ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN VAL LEU SEQRES 7 J 120 LEU LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR ALA SEQRES 8 J 120 MET TYR TYR CYS ALA ARG ASP VAL TRP LEU LEU PRO ALA SEQRES 9 J 120 THR ILE SER TYR ALA PHE ASP PHE TRP GLY GLN GLY THR SEQRES 10 J 120 MET VAL THR SEQRES 1 K 120 VAL GLN LEU VAL GLU THR GLY GLY GLY VAL VAL ARG PRO SEQRES 2 K 120 GLY ARG SER LEU ARG LEU SER CYS THR THR SER GLY PHE SEQRES 3 K 120 SER PHE SER GLY SER ALA MET HIS TRP VAL ARG GLN ALA SEQRES 4 K 120 PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER HIS SEQRES 5 K 120 ASP GLY ASN ILE ILE GLN TYR HIS ASP SER VAL LYS GLY SEQRES 6 K 120 ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN VAL LEU SEQRES 7 K 120 LEU LEU GLN MET ASN SER LEU ARG VAL ASP ASP THR ALA SEQRES 8 K 120 MET TYR TYR CYS ALA ARG ASP VAL TRP LEU LEU PRO ALA SEQRES 9 K 120 THR ILE SER TYR ALA PHE ASP PHE TRP GLY GLN GLY THR SEQRES 10 K 120 MET VAL THR SEQRES 1 M 107 VAL ILE TRP MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 M 107 SER ILE GLY ASP THR VAL THR ILE THR CYS ARG ALA SER SEQRES 3 M 107 GLN GLY ILE SER ASN SER ILE ALA TRP TYR GLN ARG ARG SEQRES 4 M 107 PRO GLY LYS ALA PRO GLU LEU LEU VAL TYR ALA ALA TYR SEQRES 5 M 107 ARG LEU GLN SER GLY VAL PRO SER ARG LEU SER GLY SER SEQRES 6 M 107 GLY SER GLY ALA GLU TYR THR LEU THR ILE LYS ASN MET SEQRES 7 M 107 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 M 107 TYR ASP ASN PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 M 107 GLU ILE LYS SEQRES 1 N 107 VAL ILE TRP MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 N 107 SER ILE GLY ASP THR VAL THR ILE THR CYS ARG ALA SER SEQRES 3 N 107 GLN GLY ILE SER ASN SER ILE ALA TRP TYR GLN ARG ARG SEQRES 4 N 107 PRO GLY LYS ALA PRO GLU LEU LEU VAL TYR ALA ALA TYR SEQRES 5 N 107 ARG LEU GLN SER GLY VAL PRO SER ARG LEU SER GLY SER SEQRES 6 N 107 GLY SER GLY ALA GLU TYR THR LEU THR ILE LYS ASN MET SEQRES 7 N 107 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 N 107 TYR ASP ASN PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 N 107 GLU ILE LYS SEQRES 1 O 107 VAL ILE TRP MET THR GLN SER PRO PRO SER LEU SER ALA SEQRES 2 O 107 SER ILE GLY ASP THR VAL THR ILE THR CYS ARG ALA SER SEQRES 3 O 107 GLN GLY ILE SER ASN SER ILE ALA TRP TYR GLN ARG ARG SEQRES 4 O 107 PRO GLY LYS ALA PRO GLU LEU LEU VAL TYR ALA ALA TYR SEQRES 5 O 107 ARG LEU GLN SER GLY VAL PRO SER ARG LEU SER GLY SER SEQRES 6 O 107 GLY SER GLY ALA GLU TYR THR LEU THR ILE LYS ASN MET SEQRES 7 O 107 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 O 107 TYR ASP ASN PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 O 107 GLU ILE LYS HET NAG A 1 14 HET NAG A 2 14 HET BMA A 3 11 HET MAN A 4 11 HET MAN A 5 11 HET NAG B 1 14 HET NAG B 2 14 HET NAG C 1 14 HET NAG C 2 14 HET BMA C 3 11 HET MAN C 4 11 HET MAN C 5 11 HET NAG D 1 14 HET NAG D 2 14 HET NAG H 1 14 HET NAG H 2 14 HET BMA H 3 11 HET MAN H 4 11 HET MAN H 5 11 HET NAG L 1 14 HET NAG L 2 14 HET NAG E 901 14 HET NAG F 901 14 HET NAG G 901 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 15(C8 H15 N O6) FORMUL 10 BMA 3(C6 H12 O6) FORMUL 10 MAN 6(C6 H12 O6) HELIX 1 AA1 PRO E 193 LYS E 200 1 8 HELIX 2 AA2 PHE E 223 ASP E 227 5 5 HELIX 3 AA3 ALA E 315 ASP E 317 5 3 HELIX 4 AA4 GLY E 410 TYR E 429 1 20 HELIX 5 AA5 ASN E 445 GLY E 447 5 3 HELIX 6 AA6 ILE E 513 ASN E 546 1 34 HELIX 7 AA7 ASN E 546 GLY E 556 1 11 HELIX 8 AA8 ALA E 577 ASP E 579 5 3 HELIX 9 AA9 SER E 660 ILE E 664 5 5 HELIX 10 AB1 PRO F 193 LYS F 200 1 8 HELIX 11 AB2 PHE F 223 ASP F 227 5 5 HELIX 12 AB3 ALA F 315 ASP F 317 5 3 HELIX 13 AB4 TYR F 402 VAL F 407 1 6 HELIX 14 AB5 GLY F 410 TYR F 429 1 20 HELIX 15 AB6 ASN F 445 GLY F 447 5 3 HELIX 16 AB7 ILE F 513 ASN F 546 1 34 HELIX 17 AB8 ASN F 546 GLY F 556 1 11 HELIX 18 AB9 ALA F 577 ASP F 579 5 3 HELIX 19 AC1 SER F 660 ILE F 664 5 5 HELIX 20 AC2 PRO G 193 LYS G 200 1 8 HELIX 21 AC3 PHE G 223 ASP G 227 5 5 HELIX 22 AC4 ALA G 315 ASP G 317 5 3 HELIX 23 AC5 GLY G 410 TYR G 429 1 20 HELIX 24 AC6 ASN G 445 GLY G 447 5 3 HELIX 25 AC7 ILE G 513 ASN G 546 1 34 HELIX 26 AC8 ASN G 546 GLY G 556 1 11 HELIX 27 AC9 ALA G 577 ASP G 579 5 3 HELIX 28 AD1 SER G 660 ILE G 664 5 5 HELIX 29 AD2 ARG I 83 THR I 87 5 5 HELIX 30 AD3 ARG J 83 THR J 87 5 5 HELIX 31 AD4 ARG K 83 THR K 87 5 5 HELIX 32 AD5 GLN M 79 PHE M 83 5 5 HELIX 33 AD6 GLN N 79 PHE N 83 5 5 HELIX 34 AD7 GLN O 79 PHE O 83 5 5 SHEET 1 AA1 2 PHE E 113 VAL E 115 0 SHEET 2 AA1 2 VAL E 574 VAL E 576 -1 O VAL E 574 N VAL E 115 SHEET 1 AA2 4 VAL E 559 MET E 563 0 SHEET 2 AA2 4 MET E 568 THR E 572 -1 O ALA E 569 N ARG E 562 SHEET 3 AA2 4 THR E 123 GLN E 126 -1 N VAL E 125 O MET E 568 SHEET 4 AA2 4 THR G 665 THR G 666 1 O THR G 665 N GLN E 126 SHEET 1 AA3 6 PHE E 395 THR E 396 0 SHEET 2 AA3 6 SER E 383 SER E 387 -1 N PHE E 386 O PHE E 395 SHEET 3 AA3 6 MET E 366 TYR E 380 -1 N LEU E 376 O SER E 387 SHEET 4 AA3 6 GLU E 144 GLU E 152 -1 N LYS E 151 O THR E 367 SHEET 5 AA3 6 LEU E 449 SER E 457 -1 O LEU E 449 N PHE E 150 SHEET 6 AA3 6 HIS E 433 LYS E 435 -1 N ILE E 434 O LEU E 456 SHEET 1 AA4 6 PHE E 395 THR E 396 0 SHEET 2 AA4 6 SER E 383 SER E 387 -1 N PHE E 386 O PHE E 395 SHEET 3 AA4 6 MET E 366 TYR E 380 -1 N LEU E 376 O SER E 387 SHEET 4 AA4 6 GLU E 144 GLU E 152 -1 N LYS E 151 O THR E 367 SHEET 5 AA4 6 LEU E 449 SER E 457 -1 O LEU E 449 N PHE E 150 SHEET 6 AA4 6 GLN E 440 LEU E 443 -1 N GLN E 440 O TYR E 452 SHEET 1 AA5 4 TYR E 157 LYS E 158 0 SHEET 2 AA5 4 ALA E 278 SER E 280 -1 O SER E 280 N TYR E 157 SHEET 3 AA5 4 PHE E 287 LEU E 289 -1 O VAL E 288 N ARG E 279 SHEET 4 AA5 4 PHE E 294 VAL E 295 -1 O VAL E 295 N PHE E 287 SHEET 1 AA6 5 ASP E 188 ALA E 190 0 SHEET 2 AA6 5 THR E 162 THR E 169 -1 N LYS E 166 O ALA E 190 SHEET 3 AA6 5 THR E 268 GLU E 274 -1 O GLU E 274 N MET E 163 SHEET 4 AA6 5 TRP E 247 HIS E 248 -1 N TRP E 247 O VAL E 273 SHEET 5 AA6 5 LYS E 235 PRO E 236 -1 N LYS E 235 O HIS E 248 SHEET 1 AA7 5 ASP E 188 ALA E 190 0 SHEET 2 AA7 5 THR E 162 THR E 169 -1 N LYS E 166 O ALA E 190 SHEET 3 AA7 5 PHE E 350 ASP E 355 -1 O THR E 351 N TYR E 164 SHEET 4 AA7 5 THR E 340 THR E 347 -1 N LEU E 345 O VAL E 352 SHEET 5 AA7 5 PHE E 319 PHE E 325 -1 N LYS E 320 O LEU E 344 SHEET 1 AA8 2 VAL E 206 CYS E 207 0 SHEET 2 AA8 2 MET E 232 GLU E 233 -1 O MET E 232 N CYS E 207 SHEET 1 AA9 2 ALA E 211 VAL E 214 0 SHEET 2 AA9 2 GLU E 219 ALA E 222 -1 O THR E 220 N TYR E 213 SHEET 1 AB1 4 VAL E 581 VAL E 583 0 SHEET 2 AB1 4 LEU E 601 ARG E 605 -1 O SER E 603 N ILE E 582 SHEET 3 AB1 4 LEU E 612 LEU E 617 -1 O VAL E 613 N PHE E 604 SHEET 4 AB1 4 LEU E 623 ARG E 624 -1 O ARG E 624 N GLN E 616 SHEET 1 AB2 2 CYS E 596 TYR E 597 0 SHEET 2 AB2 2 ILE E 630 GLU E 631 -1 O GLU E 631 N CYS E 596 SHEET 1 AB3 3 ARG E 638 PHE E 643 0 SHEET 2 AB3 3 GLY E 646 GLU E 651 -1 O GLY E 646 N PHE E 643 SHEET 3 AB3 3 TYR E 655 LEU E 659 -1 O LEU E 659 N TYR E 647 SHEET 1 AB4 4 THR E 665 THR E 666 0 SHEET 2 AB4 4 THR F 123 GLN F 126 1 O GLN F 126 N THR E 665 SHEET 3 AB4 4 MET F 568 THR F 572 -1 O MET F 568 N VAL F 125 SHEET 4 AB4 4 VAL F 559 MET F 563 -1 N SER F 560 O SER F 571 SHEET 1 AB5 2 PHE F 113 VAL F 115 0 SHEET 2 AB5 2 VAL F 574 VAL F 576 -1 O VAL F 574 N VAL F 115 SHEET 1 AB6 4 MET F 366 VAL F 372 0 SHEET 2 AB6 4 GLY F 145 GLU F 152 -1 N LYS F 151 O THR F 367 SHEET 3 AB6 4 LEU F 449 SER F 457 -1 O LEU F 449 N PHE F 150 SHEET 4 AB6 4 HIS F 433 LYS F 435 -1 N ILE F 434 O LEU F 456 SHEET 1 AB7 4 MET F 366 VAL F 372 0 SHEET 2 AB7 4 GLY F 145 GLU F 152 -1 N LYS F 151 O THR F 367 SHEET 3 AB7 4 LEU F 449 SER F 457 -1 O LEU F 449 N PHE F 150 SHEET 4 AB7 4 GLN F 440 LEU F 443 -1 N GLN F 440 O TYR F 452 SHEET 1 AB8 4 TYR F 157 LYS F 158 0 SHEET 2 AB8 4 ALA F 278 SER F 280 -1 O SER F 280 N TYR F 157 SHEET 3 AB8 4 PHE F 287 LEU F 289 -1 O VAL F 288 N ARG F 279 SHEET 4 AB8 4 PHE F 294 VAL F 295 -1 O VAL F 295 N PHE F 287 SHEET 1 AB9 5 ASP F 188 ALA F 190 0 SHEET 2 AB9 5 THR F 162 THR F 169 -1 N LYS F 166 O ALA F 190 SHEET 3 AB9 5 THR F 268 GLU F 274 -1 O ASN F 270 N ASP F 167 SHEET 4 AB9 5 TRP F 247 HIS F 248 -1 N TRP F 247 O VAL F 273 SHEET 5 AB9 5 LYS F 235 PRO F 236 -1 N LYS F 235 O HIS F 248 SHEET 1 AC1 5 ASP F 188 ALA F 190 0 SHEET 2 AC1 5 THR F 162 THR F 169 -1 N LYS F 166 O ALA F 190 SHEET 3 AC1 5 PHE F 350 ASP F 355 -1 O THR F 351 N TYR F 164 SHEET 4 AC1 5 THR F 340 THR F 347 -1 N LEU F 345 O VAL F 352 SHEET 5 AC1 5 PHE F 319 PHE F 325 -1 N LYS F 320 O LEU F 344 SHEET 1 AC2 2 VAL F 206 ARG F 208 0 SHEET 2 AC2 2 ASP F 231 GLU F 233 -1 O MET F 232 N CYS F 207 SHEET 1 AC3 2 LYS F 212 VAL F 214 0 SHEET 2 AC3 2 GLU F 219 THR F 221 -1 O THR F 220 N TYR F 213 SHEET 1 AC4 3 LEU F 376 TYR F 380 0 SHEET 2 AC4 3 SER F 383 SER F 387 -1 O ARG F 385 N SER F 378 SHEET 3 AC4 3 PHE F 395 THR F 396 -1 O PHE F 395 N PHE F 386 SHEET 1 AC5 4 VAL F 581 VAL F 583 0 SHEET 2 AC5 4 LEU F 601 ARG F 605 -1 O SER F 603 N ILE F 582 SHEET 3 AC5 4 LEU F 612 LEU F 617 -1 O VAL F 613 N PHE F 604 SHEET 4 AC5 4 LEU F 623 ARG F 624 -1 O ARG F 624 N GLN F 616 SHEET 1 AC6 2 CYS F 596 TYR F 597 0 SHEET 2 AC6 2 ILE F 630 GLU F 631 -1 O GLU F 631 N CYS F 596 SHEET 1 AC7 3 ARG F 638 PHE F 643 0 SHEET 2 AC7 3 GLY F 646 GLU F 651 -1 O GLY F 646 N PHE F 643 SHEET 3 AC7 3 TYR F 655 LEU F 659 -1 O LEU F 659 N TYR F 647 SHEET 1 AC8 4 THR F 665 THR F 666 0 SHEET 2 AC8 4 THR G 123 GLN G 126 1 O GLN G 126 N THR F 665 SHEET 3 AC8 4 MET G 568 THR G 572 -1 O MET G 568 N VAL G 125 SHEET 4 AC8 4 VAL G 559 MET G 563 -1 N ARG G 562 O ALA G 569 SHEET 1 AC9 2 PHE G 113 VAL G 115 0 SHEET 2 AC9 2 VAL G 574 VAL G 576 -1 O VAL G 574 N VAL G 115 SHEET 1 AD1 4 MET G 366 VAL G 372 0 SHEET 2 AD1 4 GLU G 144 GLU G 152 -1 N LYS G 151 O THR G 367 SHEET 3 AD1 4 LEU G 449 SER G 457 -1 O LEU G 449 N PHE G 150 SHEET 4 AD1 4 HIS G 433 LYS G 435 -1 N ILE G 434 O LEU G 456 SHEET 1 AD2 4 MET G 366 VAL G 372 0 SHEET 2 AD2 4 GLU G 144 GLU G 152 -1 N LYS G 151 O THR G 367 SHEET 3 AD2 4 LEU G 449 SER G 457 -1 O LEU G 449 N PHE G 150 SHEET 4 AD2 4 GLN G 440 LEU G 443 -1 N GLN G 440 O TYR G 452 SHEET 1 AD3 4 TYR G 157 LYS G 158 0 SHEET 2 AD3 4 ALA G 278 SER G 280 -1 O SER G 280 N TYR G 157 SHEET 3 AD3 4 PHE G 287 LEU G 289 -1 O VAL G 288 N ARG G 279 SHEET 4 AD3 4 PHE G 294 VAL G 295 -1 O VAL G 295 N PHE G 287 SHEET 1 AD4 5 ASP G 188 ALA G 190 0 SHEET 2 AD4 5 THR G 162 THR G 169 -1 N LYS G 166 O ALA G 190 SHEET 3 AD4 5 THR G 268 GLU G 274 -1 O GLU G 274 N MET G 163 SHEET 4 AD4 5 TRP G 247 HIS G 248 -1 N TRP G 247 O VAL G 273 SHEET 5 AD4 5 LYS G 235 PRO G 236 -1 N LYS G 235 O HIS G 248 SHEET 1 AD5 5 ASP G 188 ALA G 190 0 SHEET 2 AD5 5 THR G 162 THR G 169 -1 N LYS G 166 O ALA G 190 SHEET 3 AD5 5 PHE G 350 ASP G 355 -1 O THR G 351 N TYR G 164 SHEET 4 AD5 5 THR G 340 THR G 347 -1 N LEU G 345 O VAL G 352 SHEET 5 AD5 5 PHE G 319 PHE G 325 -1 N PHE G 325 O THR G 340 SHEET 1 AD6 2 VAL G 206 CYS G 207 0 SHEET 2 AD6 2 MET G 232 GLU G 233 -1 O MET G 232 N CYS G 207 SHEET 1 AD7 2 ALA G 211 VAL G 214 0 SHEET 2 AD7 2 GLU G 219 ALA G 222 -1 O ALA G 222 N ALA G 211 SHEET 1 AD8 3 LEU G 376 TYR G 380 0 SHEET 2 AD8 3 SER G 383 SER G 387 -1 O SER G 387 N LEU G 376 SHEET 3 AD8 3 PHE G 395 THR G 396 -1 O PHE G 395 N PHE G 386 SHEET 1 AD9 4 VAL G 581 VAL G 583 0 SHEET 2 AD9 4 LEU G 601 ARG G 605 -1 O SER G 603 N ILE G 582 SHEET 3 AD9 4 LEU G 612 LEU G 617 -1 O VAL G 613 N PHE G 604 SHEET 4 AD9 4 LEU G 623 ARG G 624 -1 O ARG G 624 N GLN G 616 SHEET 1 AE1 2 CYS G 596 TYR G 597 0 SHEET 2 AE1 2 ILE G 630 GLU G 631 -1 O GLU G 631 N CYS G 596 SHEET 1 AE2 3 ARG G 638 PHE G 643 0 SHEET 2 AE2 3 GLY G 646 GLU G 651 -1 O GLY G 646 N PHE G 643 SHEET 3 AE2 3 TYR G 655 LEU G 659 -1 O LEU G 659 N TYR G 647 SHEET 1 AE3 4 GLN I 3 THR I 7 0 SHEET 2 AE3 4 LEU I 18 SER I 25 -1 O SER I 21 N THR I 7 SHEET 3 AE3 4 VAL I 77 MET I 82 -1 O LEU I 78 N CYS I 22 SHEET 4 AE3 4 PHE I 67 ASP I 72 -1 N SER I 70 O LEU I 79 SHEET 1 AE4 6 GLY I 10 VAL I 11 0 SHEET 2 AE4 6 THR I 107 THR I 110 1 O THR I 110 N GLY I 10 SHEET 3 AE4 6 ALA I 88 ARG I 94 -1 N TYR I 90 O THR I 107 SHEET 4 AE4 6 MET I 34 GLN I 39 -1 N GLN I 39 O MET I 89 SHEET 5 AE4 6 LEU I 45 ILE I 51 -1 O GLU I 46 N ARG I 38 SHEET 6 AE4 6 ILE I 57 TYR I 59 -1 O GLN I 58 N VAL I 50 SHEET 1 AE5 4 GLN J 3 THR J 7 0 SHEET 2 AE5 4 LEU J 18 SER J 25 -1 O SER J 21 N THR J 7 SHEET 3 AE5 4 VAL J 77 MET J 82 -1 O LEU J 78 N CYS J 22 SHEET 4 AE5 4 PHE J 67 ASP J 72 -1 N SER J 70 O LEU J 79 SHEET 1 AE6 5 ILE J 57 TYR J 59 0 SHEET 2 AE6 5 LEU J 45 ILE J 51 -1 N VAL J 50 O GLN J 58 SHEET 3 AE6 5 MET J 34 GLN J 39 -1 N MET J 34 O ILE J 51 SHEET 4 AE6 5 ALA J 88 ARG J 94 -1 O MET J 89 N GLN J 39 SHEET 5 AE6 5 PHE J 102 TRP J 103 -1 O PHE J 102 N ARG J 94 SHEET 1 AE7 5 ILE J 57 TYR J 59 0 SHEET 2 AE7 5 LEU J 45 ILE J 51 -1 N VAL J 50 O GLN J 58 SHEET 3 AE7 5 MET J 34 GLN J 39 -1 N MET J 34 O ILE J 51 SHEET 4 AE7 5 ALA J 88 ARG J 94 -1 O MET J 89 N GLN J 39 SHEET 5 AE7 5 THR J 107 VAL J 109 -1 O THR J 107 N TYR J 90 SHEET 1 AE8 4 GLN K 3 THR K 7 0 SHEET 2 AE8 4 LEU K 18 SER K 25 -1 O SER K 21 N THR K 7 SHEET 3 AE8 4 VAL K 77 MET K 82 -1 O LEU K 78 N CYS K 22 SHEET 4 AE8 4 PHE K 67 ASP K 72 -1 N SER K 70 O LEU K 79 SHEET 1 AE9 6 GLY K 10 VAL K 11 0 SHEET 2 AE9 6 THR K 107 THR K 110 1 O THR K 110 N GLY K 10 SHEET 3 AE9 6 ALA K 88 ARG K 94 -1 N TYR K 90 O THR K 107 SHEET 4 AE9 6 MET K 34 GLN K 39 -1 N GLN K 39 O MET K 89 SHEET 5 AE9 6 LEU K 45 ILE K 51 -1 O GLU K 46 N ARG K 38 SHEET 6 AE9 6 ILE K 57 TYR K 59 -1 O GLN K 58 N VAL K 50 SHEET 1 AF1 4 GLY K 10 VAL K 11 0 SHEET 2 AF1 4 THR K 107 THR K 110 1 O THR K 110 N GLY K 10 SHEET 3 AF1 4 ALA K 88 ARG K 94 -1 N TYR K 90 O THR K 107 SHEET 4 AF1 4 PHE K 102 TRP K 103 -1 O PHE K 102 N ARG K 94 SHEET 1 AF2 4 MET M 4 SER M 7 0 SHEET 2 AF2 4 VAL M 19 ALA M 25 -1 O ARG M 24 N THR M 5 SHEET 3 AF2 4 GLU M 70 ILE M 75 -1 O TYR M 71 N CYS M 23 SHEET 4 AF2 4 LEU M 62 SER M 67 -1 N SER M 65 O THR M 72 SHEET 1 AF3 5 LEU M 11 ALA M 13 0 SHEET 2 AF3 5 THR M 102 ILE M 106 1 O GLU M 105 N ALA M 13 SHEET 3 AF3 5 THR M 85 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AF3 5 ILE M 33 ARG M 38 -1 N ALA M 34 O GLN M 89 SHEET 5 AF3 5 PRO M 44 VAL M 48 -1 O GLU M 45 N GLN M 37 SHEET 1 AF4 4 LEU M 11 ALA M 13 0 SHEET 2 AF4 4 THR M 102 ILE M 106 1 O GLU M 105 N ALA M 13 SHEET 3 AF4 4 THR M 85 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AF4 4 THR M 97 PHE M 98 -1 O THR M 97 N GLN M 90 SHEET 1 AF5 4 MET N 4 SER N 7 0 SHEET 2 AF5 4 VAL N 19 ALA N 25 -1 O ARG N 24 N THR N 5 SHEET 3 AF5 4 GLU N 70 ILE N 75 -1 O TYR N 71 N CYS N 23 SHEET 4 AF5 4 LEU N 62 SER N 67 -1 N SER N 63 O THR N 74 SHEET 1 AF6 5 LEU N 11 ALA N 13 0 SHEET 2 AF6 5 THR N 102 ILE N 106 1 O GLU N 105 N ALA N 13 SHEET 3 AF6 5 THR N 85 GLN N 90 -1 N TYR N 86 O THR N 102 SHEET 4 AF6 5 ILE N 33 ARG N 38 -1 N ALA N 34 O GLN N 89 SHEET 5 AF6 5 PRO N 44 TYR N 49 -1 O GLU N 45 N GLN N 37 SHEET 1 AF7 4 LEU N 11 ALA N 13 0 SHEET 2 AF7 4 THR N 102 ILE N 106 1 O GLU N 105 N ALA N 13 SHEET 3 AF7 4 THR N 85 GLN N 90 -1 N TYR N 86 O THR N 102 SHEET 4 AF7 4 THR N 97 PHE N 98 -1 O THR N 97 N GLN N 90 SHEET 1 AF8 4 MET O 4 SER O 7 0 SHEET 2 AF8 4 VAL O 19 ALA O 25 -1 O ARG O 24 N THR O 5 SHEET 3 AF8 4 GLU O 70 ILE O 75 -1 O TYR O 71 N CYS O 23 SHEET 4 AF8 4 LEU O 62 SER O 67 -1 N SER O 63 O THR O 74 SHEET 1 AF9 5 SER O 10 ALA O 13 0 SHEET 2 AF9 5 THR O 102 ILE O 106 1 O LYS O 103 N LEU O 11 SHEET 3 AF9 5 THR O 85 GLN O 90 -1 N TYR O 86 O THR O 102 SHEET 4 AF9 5 ILE O 33 ARG O 38 -1 N ALA O 34 O GLN O 89 SHEET 5 AF9 5 PRO O 44 TYR O 49 -1 O GLU O 45 N GLN O 37 SHEET 1 AG1 4 SER O 10 ALA O 13 0 SHEET 2 AG1 4 THR O 102 ILE O 106 1 O LYS O 103 N LEU O 11 SHEET 3 AG1 4 THR O 85 GLN O 90 -1 N TYR O 86 O THR O 102 SHEET 4 AG1 4 THR O 97 PHE O 98 -1 O THR O 97 N GLN O 90 SSBOND 1 CYS E 116 CYS E 573 1555 1555 2.03 SSBOND 2 CYS E 133 CYS E 529 1555 1555 2.03 SSBOND 3 CYS E 207 CYS E 271 1555 1555 2.03 SSBOND 4 CYS E 240 CYS E 607 1555 1555 2.04 SSBOND 5 CYS E 364 CYS E 412 1555 1555 2.03 SSBOND 6 CYS E 596 CYS E 633 1555 1555 2.04 SSBOND 7 CYS F 116 CYS F 573 1555 1555 2.03 SSBOND 8 CYS F 133 CYS F 529 1555 1555 2.03 SSBOND 9 CYS F 207 CYS F 271 1555 1555 2.03 SSBOND 10 CYS F 240 CYS F 607 1555 1555 2.04 SSBOND 11 CYS F 364 CYS F 412 1555 1555 2.03 SSBOND 12 CYS F 596 CYS F 633 1555 1555 2.04 SSBOND 13 CYS G 116 CYS G 573 1555 1555 2.03 SSBOND 14 CYS G 133 CYS G 529 1555 1555 2.03 SSBOND 15 CYS G 207 CYS G 271 1555 1555 2.03 SSBOND 16 CYS G 240 CYS G 607 1555 1555 2.03 SSBOND 17 CYS G 364 CYS G 412 1555 1555 2.03 SSBOND 18 CYS G 596 CYS G 633 1555 1555 2.04 SSBOND 19 CYS I 22 CYS I 92 1555 1555 2.04 SSBOND 20 CYS J 22 CYS J 92 1555 1555 2.03 SSBOND 21 CYS K 22 CYS K 92 1555 1555 2.03 SSBOND 22 CYS M 23 CYS M 88 1555 1555 2.04 SSBOND 23 CYS N 23 CYS N 88 1555 1555 2.04 SSBOND 24 CYS O 23 CYS O 88 1555 1555 2.04 LINK ND2 ASN E 141 C1 NAG A 1 1555 1555 1.44 LINK ND2 ASN E 398 C1 NAG B 1 1555 1555 1.44 LINK ND2 ASN E 430 C1 NAG E 901 1555 1555 1.44 LINK ND2 ASN F 141 C1 NAG C 1 1555 1555 1.45 LINK ND2 ASN F 398 C1 NAG D 1 1555 1555 1.44 LINK ND2 ASN F 430 C1 NAG F 901 1555 1555 1.44 LINK ND2 ASN G 141 C1 NAG H 1 1555 1555 1.44 LINK ND2 ASN G 398 C1 NAG L 1 1555 1555 1.44 LINK ND2 ASN G 430 C1 NAG G 901 1555 1555 1.44 LINK O4 NAG A 1 C1 NAG A 2 1555 1555 1.44 LINK O4 NAG A 2 C1 BMA A 3 1555 1555 1.45 LINK O6 BMA A 3 C1 MAN A 4 1555 1555 1.45 LINK O6 MAN A 4 C1 MAN A 5 1555 1555 1.45 LINK O4 NAG B 1 C1 NAG B 2 1555 1555 1.45 LINK O4 NAG C 1 C1 NAG C 2 1555 1555 1.44 LINK O4 NAG C 2 C1 BMA C 3 1555 1555 1.45 LINK O6 BMA C 3 C1 MAN C 4 1555 1555 1.45 LINK O6 MAN C 4 C1 MAN C 5 1555 1555 1.45 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.45 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.45 LINK O4 NAG H 2 C1 BMA H 3 1555 1555 1.45 LINK O6 BMA H 3 C1 MAN H 4 1555 1555 1.45 LINK O6 MAN H 4 C1 MAN H 5 1555 1555 1.45 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.45 CISPEP 1 SER M 7 PRO M 8 0 -0.94 CISPEP 2 ASN M 94 PRO M 95 0 0.28 CISPEP 3 SER N 7 PRO N 8 0 -0.83 CISPEP 4 ASN N 94 PRO N 95 0 -0.34 CISPEP 5 SER O 7 PRO O 8 0 -0.56 CISPEP 6 ASN O 94 PRO O 95 0 -0.41 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000