HEADER VIRAL PROTEIN/IMMUNE SYSTEM 04-SEP-24 9DHY TITLE STRUCTURE OF SARS-COV-2 SPIKE IN COMPLEX WITH ANTIBODY FAB COVIC-154 COMPND MOL_ID: 1; COMPND 2 MOLECULE: ANTIBODY FAB COVIC-154 HEAVY CHAIN; COMPND 3 CHAIN: A, D, I; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: ANTIBODY FAB COVIC-154 LIGHT CHAIN; COMPND 7 CHAIN: B, E, J; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 11 CHAIN: C, F, K; COMPND 12 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 13 2; SOURCE 14 ORGANISM_TAXID: 2697049; SOURCE 15 GENE: S, 2; SOURCE 16 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 10029 KEYWDS VIRAL PROTEIN, GLYCOPROTEIN, IMMUNE SYSTEM, ANTIBODY, SARS-COV-2, KEYWDS 2 COVID, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX, CORONAVIRUS, ANTIVIRAL KEYWDS 3 PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR X.YU,E.O.SAPHIRE REVDAT 1 16-APR-25 9DHY 0 JRNL AUTH S.L.SCHENDEL,X.YU,P.J.HALFMANN,J.MAHITA,B.HA,K.M.HASTIE, JRNL AUTH 2 H.LI,D.BEDINGER,C.TROUP,K.LI,N.KUZMINA,J.B.TORRELLES, JRNL AUTH 3 J.E.MUNT,M.MADDOCKS,M.OSEI-TWUM,H.M.CALLAWAY,S.REECE, JRNL AUTH 4 A.PALSER,P.KELLAM,S.M.DENNISON,R.H.C.HUNTWORK,G.Q.HORN, JRNL AUTH 5 M.ABRAHA,E.FEENEY,L.MARTINEZ-SOBRIDO,P.A.PINO,A.HICKS,C.YE, JRNL AUTH 6 J.G.PARK,B.MAINGOT,S.PERIASAMY,M.MALLORY,T.SCOBEY, JRNL AUTH 7 M.N.LEPAGE,N.ST-AMANT,S.KHAN,A.GAMBIEZ,R.S.BARIC,A.BUKREYEV, JRNL AUTH 8 L.GAGNON,T.GERMANN,Y.KAWAOKA,G.D.TOMARAS,B.PETERS, JRNL AUTH 9 E.O.SAPHIRE JRNL TITL A GLOBAL COLLABORATION FOR SYSTEMATIC ANALYSIS OF JRNL TITL 2 BROAD-RANGING ANTIBODIES AGAINST THE SARS-COV-2 SPIKE JRNL TITL 3 PROTEIN. JRNL REF CELL REP V. 44 15499 2025 JRNL REFN ESSN 2211-1247 JRNL PMID 40184253 JRNL DOI 10.1016/J.CELREP.2025.115499 REMARK 2 REMARK 2 RESOLUTION. 2.70 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, EPU, CRYOSPARC, PHENIX, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.700 REMARK 3 NUMBER OF PARTICLES : 131404 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9DHY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 05-SEP-24. REMARK 100 THE DEPOSITION ID IS D_1000288090. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : STRUCTURE OF SARS-COV-2 SPIKE REMARK 245 IN COMPLEX WITH ANTIBODY COVIC- REMARK 245 154 FAB; ANTIBODY COVIC-154 FAB REMARK 245 HEAVY CHAIN,ANTIBODY COVIC-154 REMARK 245 FAB LIGHT CHAIN; SARS-COV-2 REMARK 245 SPIKE GLYCOPROTEIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, I, J, K, M, REMARK 350 AND CHAINS: G, H, N, L, O, P, Q, R REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA B 1 REMARK 465 MET C -3 REMARK 465 GLY C -2 REMARK 465 VAL C -1 REMARK 465 LYS C 0 REMARK 465 VAL C 1 REMARK 465 LEU C 2 REMARK 465 PHE C 3 REMARK 465 ALA C 4 REMARK 465 LEU C 5 REMARK 465 ILE C 6 REMARK 465 CYS C 7 REMARK 465 ILE C 8 REMARK 465 ALA C 9 REMARK 465 VAL C 10 REMARK 465 ALA C 11 REMARK 465 GLU C 12 REMARK 465 ALA C 13 REMARK 465 GLN C 14 REMARK 465 CYS C 15 REMARK 465 VAL C 16 REMARK 465 ASN C 17 REMARK 465 LEU C 18 REMARK 465 THR C 19 REMARK 465 THR C 20 REMARK 465 ARG C 21 REMARK 465 THR C 22 REMARK 465 GLN C 23 REMARK 465 LEU C 24 REMARK 465 PRO C 25 REMARK 465 PRO C 26 REMARK 465 ALA C 27 REMARK 465 ALA C 67 REMARK 465 ILE C 68 REMARK 465 HIS C 69 REMARK 465 VAL C 70 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 76 REMARK 465 LYS C 77 REMARK 465 ARG C 78 REMARK 465 PHE C 79 REMARK 465 ASP C 80 REMARK 465 ASN C 81 REMARK 465 PRO C 82 REMARK 465 THR C 108 REMARK 465 THR C 109 REMARK 465 LEU C 110 REMARK 465 ASP C 111 REMARK 465 SER C 112 REMARK 465 LYS C 113 REMARK 465 THR C 114 REMARK 465 GLN C 115 REMARK 465 GLU C 132 REMARK 465 PHE C 133 REMARK 465 GLN C 134 REMARK 465 PHE C 135 REMARK 465 CYS C 136 REMARK 465 ASN C 137 REMARK 465 ASP C 138 REMARK 465 PRO C 139 REMARK 465 PHE C 140 REMARK 465 LEU C 141 REMARK 465 GLY C 142 REMARK 465 VAL C 143 REMARK 465 TYR C 144 REMARK 465 TYR C 145 REMARK 465 HIS C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 MET C 153 REMARK 465 GLU C 154 REMARK 465 SER C 155 REMARK 465 GLU C 156 REMARK 465 PHE C 157 REMARK 465 ARG C 158 REMARK 465 VAL C 159 REMARK 465 TYR C 160 REMARK 465 SER C 161 REMARK 465 SER C 162 REMARK 465 ALA C 163 REMARK 465 ASN C 164 REMARK 465 ASN C 165 REMARK 465 PRO C 174 REMARK 465 PHE C 175 REMARK 465 LEU C 176 REMARK 465 MET C 177 REMARK 465 ASP C 178 REMARK 465 LEU C 179 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLN C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 PHE C 186 REMARK 465 LYS C 187 REMARK 465 ALA C 243 REMARK 465 LEU C 244 REMARK 465 HIS C 245 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 GLY C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 GLY C 261 REMARK 465 ALA C 262 REMARK 465 ALA C 263 REMARK 465 LYS C 444 REMARK 465 VAL C 445 REMARK 465 GLY C 446 REMARK 465 GLY C 447 REMARK 465 ASN C 448 REMARK 465 TYR C 449 REMARK 465 ASN C 450 REMARK 465 TYR C 451 REMARK 465 LEU C 455 REMARK 465 PHE C 456 REMARK 465 ARG C 457 REMARK 465 LYS C 458 REMARK 465 SER C 459 REMARK 465 ASN C 460 REMARK 465 LEU C 461 REMARK 465 ASP C 467 REMARK 465 ILE C 468 REMARK 465 SER C 469 REMARK 465 THR C 470 REMARK 465 GLU C 471 REMARK 465 ILE C 472 REMARK 465 TYR C 473 REMARK 465 GLN C 474 REMARK 465 ALA C 475 REMARK 465 GLY C 476 REMARK 465 SER C 477 REMARK 465 THR C 478 REMARK 465 PRO C 479 REMARK 465 CYS C 480 REMARK 465 ASN C 481 REMARK 465 GLY C 482 REMARK 465 VAL C 483 REMARK 465 GLU C 484 REMARK 465 GLY C 485 REMARK 465 PHE C 486 REMARK 465 ASN C 487 REMARK 465 CYS C 488 REMARK 465 TYR C 489 REMARK 465 PHE C 490 REMARK 465 PRO C 491 REMARK 465 LEU C 492 REMARK 465 GLN C 493 REMARK 465 SER C 494 REMARK 465 TYR C 495 REMARK 465 GLY C 496 REMARK 465 PHE C 497 REMARK 465 GLN C 498 REMARK 465 PRO C 499 REMARK 465 THR C 500 REMARK 465 ASN C 501 REMARK 465 GLY C 502 REMARK 465 VAL C 503 REMARK 465 PRO C 621 REMARK 465 VAL C 622 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 THR C 638 REMARK 465 GLY C 639 REMARK 465 SER C 640 REMARK 465 THR C 676 REMARK 465 GLN C 677 REMARK 465 THR C 678 REMARK 465 ASN C 679 REMARK 465 SER C 680 REMARK 465 PRO C 681 REMARK 465 GLY C 682 REMARK 465 SER C 683 REMARK 465 ALA C 684 REMARK 465 SER C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 SER C 689 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 CYS C 851 REMARK 465 ALA C 852 REMARK 465 GLN C 853 REMARK 465 LYS C 854 REMARK 465 ASP C 1146 REMARK 465 SER C 1147 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 ALA E 1 REMARK 465 MET F -3 REMARK 465 GLY F -2 REMARK 465 VAL F -1 REMARK 465 LYS F 0 REMARK 465 VAL F 1 REMARK 465 LEU F 2 REMARK 465 PHE F 3 REMARK 465 ALA F 4 REMARK 465 LEU F 5 REMARK 465 ILE F 6 REMARK 465 CYS F 7 REMARK 465 ILE F 8 REMARK 465 ALA F 9 REMARK 465 VAL F 10 REMARK 465 ALA F 11 REMARK 465 GLU F 12 REMARK 465 ALA F 13 REMARK 465 GLN F 14 REMARK 465 CYS F 15 REMARK 465 VAL F 16 REMARK 465 ASN F 17 REMARK 465 LEU F 18 REMARK 465 THR F 19 REMARK 465 THR F 20 REMARK 465 ARG F 21 REMARK 465 THR F 22 REMARK 465 GLN F 23 REMARK 465 LEU F 24 REMARK 465 PRO F 25 REMARK 465 PRO F 26 REMARK 465 ALA F 27 REMARK 465 ALA F 67 REMARK 465 ILE F 68 REMARK 465 HIS F 69 REMARK 465 VAL F 70 REMARK 465 SER F 71 REMARK 465 GLY F 72 REMARK 465 THR F 73 REMARK 465 ASN F 74 REMARK 465 GLY F 75 REMARK 465 THR F 76 REMARK 465 LYS F 77 REMARK 465 ARG F 78 REMARK 465 PHE F 79 REMARK 465 ASP F 80 REMARK 465 ASN F 81 REMARK 465 PRO F 82 REMARK 465 THR F 109 REMARK 465 LEU F 110 REMARK 465 ASP F 111 REMARK 465 SER F 112 REMARK 465 LYS F 113 REMARK 465 THR F 114 REMARK 465 GLU F 132 REMARK 465 PHE F 133 REMARK 465 GLN F 134 REMARK 465 PHE F 135 REMARK 465 CYS F 136 REMARK 465 ASN F 137 REMARK 465 ASP F 138 REMARK 465 PRO F 139 REMARK 465 PHE F 140 REMARK 465 LEU F 141 REMARK 465 GLY F 142 REMARK 465 VAL F 143 REMARK 465 TYR F 144 REMARK 465 TYR F 145 REMARK 465 HIS F 146 REMARK 465 LYS F 147 REMARK 465 ASN F 148 REMARK 465 ASN F 149 REMARK 465 LYS F 150 REMARK 465 SER F 151 REMARK 465 TRP F 152 REMARK 465 MET F 153 REMARK 465 GLU F 154 REMARK 465 SER F 155 REMARK 465 GLU F 156 REMARK 465 PHE F 157 REMARK 465 ARG F 158 REMARK 465 VAL F 159 REMARK 465 TYR F 160 REMARK 465 SER F 161 REMARK 465 SER F 162 REMARK 465 ALA F 163 REMARK 465 ASN F 164 REMARK 465 ASN F 165 REMARK 465 PRO F 174 REMARK 465 PHE F 175 REMARK 465 LEU F 176 REMARK 465 MET F 177 REMARK 465 ASP F 178 REMARK 465 LEU F 179 REMARK 465 GLU F 180 REMARK 465 GLY F 181 REMARK 465 LYS F 182 REMARK 465 GLN F 183 REMARK 465 GLY F 184 REMARK 465 ASN F 185 REMARK 465 PHE F 186 REMARK 465 LYS F 187 REMARK 465 ALA F 243 REMARK 465 LEU F 244 REMARK 465 HIS F 245 REMARK 465 ARG F 246 REMARK 465 SER F 247 REMARK 465 TYR F 248 REMARK 465 LEU F 249 REMARK 465 THR F 250 REMARK 465 PRO F 251 REMARK 465 GLY F 252 REMARK 465 ASP F 253 REMARK 465 SER F 254 REMARK 465 SER F 255 REMARK 465 SER F 256 REMARK 465 GLY F 257 REMARK 465 TRP F 258 REMARK 465 THR F 259 REMARK 465 ALA F 260 REMARK 465 GLY F 261 REMARK 465 ALA F 262 REMARK 465 ALA F 263 REMARK 465 LYS F 444 REMARK 465 VAL F 445 REMARK 465 GLY F 446 REMARK 465 GLY F 447 REMARK 465 ASN F 448 REMARK 465 TYR F 449 REMARK 465 ASN F 450 REMARK 465 TYR F 451 REMARK 465 LEU F 455 REMARK 465 PHE F 456 REMARK 465 ARG F 457 REMARK 465 LYS F 458 REMARK 465 SER F 459 REMARK 465 ASN F 460 REMARK 465 LEU F 461 REMARK 465 ASP F 467 REMARK 465 ILE F 468 REMARK 465 SER F 469 REMARK 465 THR F 470 REMARK 465 GLU F 471 REMARK 465 ILE F 472 REMARK 465 TYR F 473 REMARK 465 GLN F 474 REMARK 465 ALA F 475 REMARK 465 GLY F 476 REMARK 465 SER F 477 REMARK 465 THR F 478 REMARK 465 PRO F 479 REMARK 465 CYS F 480 REMARK 465 ASN F 481 REMARK 465 GLY F 482 REMARK 465 VAL F 483 REMARK 465 GLU F 484 REMARK 465 GLY F 485 REMARK 465 PHE F 486 REMARK 465 ASN F 487 REMARK 465 CYS F 488 REMARK 465 TYR F 489 REMARK 465 PHE F 490 REMARK 465 PRO F 491 REMARK 465 LEU F 492 REMARK 465 GLN F 493 REMARK 465 SER F 494 REMARK 465 TYR F 495 REMARK 465 GLY F 496 REMARK 465 PHE F 497 REMARK 465 GLN F 498 REMARK 465 PRO F 499 REMARK 465 THR F 500 REMARK 465 ASN F 501 REMARK 465 GLY F 502 REMARK 465 VAL F 503 REMARK 465 PRO F 621 REMARK 465 VAL F 622 REMARK 465 ALA F 623 REMARK 465 ILE F 624 REMARK 465 HIS F 625 REMARK 465 ALA F 626 REMARK 465 ASP F 627 REMARK 465 GLN F 628 REMARK 465 LEU F 629 REMARK 465 THR F 630 REMARK 465 PRO F 631 REMARK 465 THR F 632 REMARK 465 TRP F 633 REMARK 465 ARG F 634 REMARK 465 VAL F 635 REMARK 465 TYR F 636 REMARK 465 SER F 637 REMARK 465 THR F 638 REMARK 465 GLY F 639 REMARK 465 SER F 640 REMARK 465 THR F 676 REMARK 465 GLN F 677 REMARK 465 THR F 678 REMARK 465 ASN F 679 REMARK 465 SER F 680 REMARK 465 PRO F 681 REMARK 465 GLY F 682 REMARK 465 SER F 683 REMARK 465 ALA F 684 REMARK 465 SER F 685 REMARK 465 SER F 686 REMARK 465 VAL F 687 REMARK 465 ALA F 688 REMARK 465 SER F 689 REMARK 465 LEU F 828 REMARK 465 ALA F 829 REMARK 465 ASP F 830 REMARK 465 ALA F 831 REMARK 465 GLY F 832 REMARK 465 PHE F 833 REMARK 465 ILE F 834 REMARK 465 LYS F 835 REMARK 465 GLN F 836 REMARK 465 TYR F 837 REMARK 465 GLY F 838 REMARK 465 ASP F 839 REMARK 465 CYS F 840 REMARK 465 LEU F 841 REMARK 465 GLY F 842 REMARK 465 ASP F 843 REMARK 465 ILE F 844 REMARK 465 ALA F 845 REMARK 465 ALA F 846 REMARK 465 ARG F 847 REMARK 465 ASP F 848 REMARK 465 LEU F 849 REMARK 465 ILE F 850 REMARK 465 CYS F 851 REMARK 465 ALA F 852 REMARK 465 GLN F 853 REMARK 465 LYS F 854 REMARK 465 ASP F 1146 REMARK 465 SER F 1147 REMARK 465 PHE F 1148 REMARK 465 LYS F 1149 REMARK 465 GLU F 1150 REMARK 465 GLU F 1151 REMARK 465 LEU F 1152 REMARK 465 ASP F 1153 REMARK 465 LYS F 1154 REMARK 465 TYR F 1155 REMARK 465 PHE F 1156 REMARK 465 LYS F 1157 REMARK 465 ASN F 1158 REMARK 465 HIS F 1159 REMARK 465 THR F 1160 REMARK 465 SER F 1161 REMARK 465 PRO F 1162 REMARK 465 ASP F 1163 REMARK 465 VAL F 1164 REMARK 465 ASP F 1165 REMARK 465 LEU F 1166 REMARK 465 GLY F 1167 REMARK 465 ASP F 1168 REMARK 465 ILE F 1169 REMARK 465 SER F 1170 REMARK 465 GLY F 1171 REMARK 465 ILE F 1172 REMARK 465 ASN F 1173 REMARK 465 ALA F 1174 REMARK 465 SER F 1175 REMARK 465 VAL F 1176 REMARK 465 VAL F 1177 REMARK 465 ASN F 1178 REMARK 465 ILE F 1179 REMARK 465 GLN F 1180 REMARK 465 LYS F 1181 REMARK 465 GLU F 1182 REMARK 465 ILE F 1183 REMARK 465 ASP F 1184 REMARK 465 ARG F 1185 REMARK 465 LEU F 1186 REMARK 465 ASN F 1187 REMARK 465 GLU F 1188 REMARK 465 VAL F 1189 REMARK 465 ALA F 1190 REMARK 465 LYS F 1191 REMARK 465 ASN F 1192 REMARK 465 LEU F 1193 REMARK 465 ASN F 1194 REMARK 465 GLU F 1195 REMARK 465 SER F 1196 REMARK 465 LEU F 1197 REMARK 465 ILE F 1198 REMARK 465 ASP F 1199 REMARK 465 LEU F 1200 REMARK 465 GLN F 1201 REMARK 465 GLU F 1202 REMARK 465 LEU F 1203 REMARK 465 GLY F 1204 REMARK 465 LYS F 1205 REMARK 465 TYR F 1206 REMARK 465 GLU F 1207 REMARK 465 GLN F 1208 REMARK 465 ALA J 1 REMARK 465 MET K -3 REMARK 465 GLY K -2 REMARK 465 VAL K -1 REMARK 465 LYS K 0 REMARK 465 VAL K 1 REMARK 465 LEU K 2 REMARK 465 PHE K 3 REMARK 465 ALA K 4 REMARK 465 LEU K 5 REMARK 465 ILE K 6 REMARK 465 CYS K 7 REMARK 465 ILE K 8 REMARK 465 ALA K 9 REMARK 465 VAL K 10 REMARK 465 ALA K 11 REMARK 465 GLU K 12 REMARK 465 ALA K 13 REMARK 465 GLN K 14 REMARK 465 CYS K 15 REMARK 465 VAL K 16 REMARK 465 ASN K 17 REMARK 465 LEU K 18 REMARK 465 THR K 19 REMARK 465 THR K 20 REMARK 465 ARG K 21 REMARK 465 THR K 22 REMARK 465 GLN K 23 REMARK 465 LEU K 24 REMARK 465 PRO K 25 REMARK 465 PRO K 26 REMARK 465 ALA K 27 REMARK 465 ALA K 67 REMARK 465 ILE K 68 REMARK 465 HIS K 69 REMARK 465 VAL K 70 REMARK 465 SER K 71 REMARK 465 GLY K 72 REMARK 465 THR K 73 REMARK 465 ASN K 74 REMARK 465 GLY K 75 REMARK 465 THR K 76 REMARK 465 LYS K 77 REMARK 465 ARG K 78 REMARK 465 PHE K 79 REMARK 465 ASP K 80 REMARK 465 ASN K 81 REMARK 465 PRO K 82 REMARK 465 THR K 109 REMARK 465 LEU K 110 REMARK 465 ASP K 111 REMARK 465 SER K 112 REMARK 465 LYS K 113 REMARK 465 THR K 114 REMARK 465 GLU K 132 REMARK 465 PHE K 133 REMARK 465 GLN K 134 REMARK 465 PHE K 135 REMARK 465 CYS K 136 REMARK 465 ASN K 137 REMARK 465 ASP K 138 REMARK 465 PRO K 139 REMARK 465 PHE K 140 REMARK 465 LEU K 141 REMARK 465 GLY K 142 REMARK 465 VAL K 143 REMARK 465 TYR K 144 REMARK 465 TYR K 145 REMARK 465 HIS K 146 REMARK 465 LYS K 147 REMARK 465 ASN K 148 REMARK 465 ASN K 149 REMARK 465 LYS K 150 REMARK 465 SER K 151 REMARK 465 TRP K 152 REMARK 465 MET K 153 REMARK 465 GLU K 154 REMARK 465 SER K 155 REMARK 465 GLU K 156 REMARK 465 PHE K 157 REMARK 465 ARG K 158 REMARK 465 VAL K 159 REMARK 465 TYR K 160 REMARK 465 SER K 161 REMARK 465 SER K 162 REMARK 465 ALA K 163 REMARK 465 ASN K 164 REMARK 465 ASN K 165 REMARK 465 PRO K 174 REMARK 465 PHE K 175 REMARK 465 LEU K 176 REMARK 465 MET K 177 REMARK 465 ASP K 178 REMARK 465 LEU K 179 REMARK 465 GLU K 180 REMARK 465 GLY K 181 REMARK 465 LYS K 182 REMARK 465 GLN K 183 REMARK 465 GLY K 184 REMARK 465 ASN K 185 REMARK 465 PHE K 186 REMARK 465 LYS K 187 REMARK 465 ALA K 243 REMARK 465 LEU K 244 REMARK 465 HIS K 245 REMARK 465 ARG K 246 REMARK 465 SER K 247 REMARK 465 TYR K 248 REMARK 465 LEU K 249 REMARK 465 THR K 250 REMARK 465 PRO K 251 REMARK 465 GLY K 252 REMARK 465 ASP K 253 REMARK 465 SER K 254 REMARK 465 SER K 255 REMARK 465 SER K 256 REMARK 465 GLY K 257 REMARK 465 TRP K 258 REMARK 465 THR K 259 REMARK 465 ALA K 260 REMARK 465 GLY K 261 REMARK 465 ALA K 262 REMARK 465 ALA K 263 REMARK 465 LYS K 444 REMARK 465 VAL K 445 REMARK 465 GLY K 446 REMARK 465 GLY K 447 REMARK 465 ASN K 448 REMARK 465 TYR K 449 REMARK 465 ASN K 450 REMARK 465 TYR K 451 REMARK 465 LEU K 455 REMARK 465 PHE K 456 REMARK 465 ARG K 457 REMARK 465 LYS K 458 REMARK 465 SER K 459 REMARK 465 ASN K 460 REMARK 465 LEU K 461 REMARK 465 ASP K 467 REMARK 465 ILE K 468 REMARK 465 SER K 469 REMARK 465 THR K 470 REMARK 465 GLU K 471 REMARK 465 ILE K 472 REMARK 465 TYR K 473 REMARK 465 GLN K 474 REMARK 465 ALA K 475 REMARK 465 GLY K 476 REMARK 465 SER K 477 REMARK 465 THR K 478 REMARK 465 PRO K 479 REMARK 465 CYS K 480 REMARK 465 ASN K 481 REMARK 465 GLY K 482 REMARK 465 VAL K 483 REMARK 465 GLU K 484 REMARK 465 GLY K 485 REMARK 465 PHE K 486 REMARK 465 ASN K 487 REMARK 465 CYS K 488 REMARK 465 TYR K 489 REMARK 465 PHE K 490 REMARK 465 PRO K 491 REMARK 465 LEU K 492 REMARK 465 GLN K 493 REMARK 465 SER K 494 REMARK 465 TYR K 495 REMARK 465 GLY K 496 REMARK 465 PHE K 497 REMARK 465 GLN K 498 REMARK 465 PRO K 499 REMARK 465 THR K 500 REMARK 465 ASN K 501 REMARK 465 GLY K 502 REMARK 465 VAL K 503 REMARK 465 PRO K 621 REMARK 465 VAL K 622 REMARK 465 ALA K 623 REMARK 465 ILE K 624 REMARK 465 HIS K 625 REMARK 465 ALA K 626 REMARK 465 ASP K 627 REMARK 465 GLN K 628 REMARK 465 LEU K 629 REMARK 465 THR K 630 REMARK 465 PRO K 631 REMARK 465 THR K 632 REMARK 465 TRP K 633 REMARK 465 ARG K 634 REMARK 465 VAL K 635 REMARK 465 TYR K 636 REMARK 465 SER K 637 REMARK 465 THR K 638 REMARK 465 GLY K 639 REMARK 465 SER K 640 REMARK 465 THR K 676 REMARK 465 GLN K 677 REMARK 465 THR K 678 REMARK 465 ASN K 679 REMARK 465 SER K 680 REMARK 465 PRO K 681 REMARK 465 GLY K 682 REMARK 465 SER K 683 REMARK 465 ALA K 684 REMARK 465 SER K 685 REMARK 465 SER K 686 REMARK 465 VAL K 687 REMARK 465 ALA K 688 REMARK 465 SER K 689 REMARK 465 LEU K 828 REMARK 465 ALA K 829 REMARK 465 ASP K 830 REMARK 465 ALA K 831 REMARK 465 GLY K 832 REMARK 465 PHE K 833 REMARK 465 ILE K 834 REMARK 465 LYS K 835 REMARK 465 GLN K 836 REMARK 465 TYR K 837 REMARK 465 GLY K 838 REMARK 465 ASP K 839 REMARK 465 CYS K 840 REMARK 465 LEU K 841 REMARK 465 GLY K 842 REMARK 465 ASP K 843 REMARK 465 ILE K 844 REMARK 465 ALA K 845 REMARK 465 ALA K 846 REMARK 465 ARG K 847 REMARK 465 ASP K 848 REMARK 465 LEU K 849 REMARK 465 ILE K 850 REMARK 465 CYS K 851 REMARK 465 ALA K 852 REMARK 465 GLN K 853 REMARK 465 LYS K 854 REMARK 465 ASP K 1146 REMARK 465 SER K 1147 REMARK 465 PHE K 1148 REMARK 465 LYS K 1149 REMARK 465 GLU K 1150 REMARK 465 GLU K 1151 REMARK 465 LEU K 1152 REMARK 465 ASP K 1153 REMARK 465 LYS K 1154 REMARK 465 TYR K 1155 REMARK 465 PHE K 1156 REMARK 465 LYS K 1157 REMARK 465 ASN K 1158 REMARK 465 HIS K 1159 REMARK 465 THR K 1160 REMARK 465 SER K 1161 REMARK 465 PRO K 1162 REMARK 465 ASP K 1163 REMARK 465 VAL K 1164 REMARK 465 ASP K 1165 REMARK 465 LEU K 1166 REMARK 465 GLY K 1167 REMARK 465 ASP K 1168 REMARK 465 ILE K 1169 REMARK 465 SER K 1170 REMARK 465 GLY K 1171 REMARK 465 ILE K 1172 REMARK 465 ASN K 1173 REMARK 465 ALA K 1174 REMARK 465 SER K 1175 REMARK 465 VAL K 1176 REMARK 465 VAL K 1177 REMARK 465 ASN K 1178 REMARK 465 ILE K 1179 REMARK 465 GLN K 1180 REMARK 465 LYS K 1181 REMARK 465 GLU K 1182 REMARK 465 ILE K 1183 REMARK 465 ASP K 1184 REMARK 465 ARG K 1185 REMARK 465 LEU K 1186 REMARK 465 ASN K 1187 REMARK 465 GLU K 1188 REMARK 465 VAL K 1189 REMARK 465 ALA K 1190 REMARK 465 LYS K 1191 REMARK 465 ASN K 1192 REMARK 465 LEU K 1193 REMARK 465 ASN K 1194 REMARK 465 GLU K 1195 REMARK 465 SER K 1196 REMARK 465 LEU K 1197 REMARK 465 ILE K 1198 REMARK 465 ASP K 1199 REMARK 465 LEU K 1200 REMARK 465 GLN K 1201 REMARK 465 GLU K 1202 REMARK 465 LEU K 1203 REMARK 465 GLY K 1204 REMARK 465 LYS K 1205 REMARK 465 TYR K 1206 REMARK 465 GLU K 1207 REMARK 465 GLN K 1208 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 PRO C 892 CG CD REMARK 470 PRO C 899 CG CD REMARK 470 PRO C 942 CG CD REMARK 470 LEU C1145 CD2 REMARK 470 PRO F 892 CG CD REMARK 470 PRO F 899 CG CD REMARK 470 PRO F 942 CG CD REMARK 470 LEU F1145 CD2 REMARK 470 PRO K 892 CG CD REMARK 470 PRO K 899 CG CD REMARK 470 PRO K 942 CG CD REMARK 470 LEU K1145 CD1 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 ND2 ASN C 801 O5 NAG G 1 2.19 REMARK 500 ND2 ASN F 801 O5 NAG L 1 2.19 REMARK 500 ND2 ASN K 801 O5 NAG Q 1 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ARG B 30 -125.14 53.87 REMARK 500 ASP B 50 -130.03 56.02 REMARK 500 PHE C 32 -130.46 55.84 REMARK 500 ASN C 122 -126.44 49.50 REMARK 500 THR C 124 -121.10 46.31 REMARK 500 LEU C 226 -65.04 -103.44 REMARK 500 PRO C 230 47.22 -84.61 REMARK 500 LYS C 304 15.56 53.64 REMARK 500 PRO C 337 48.40 -91.01 REMARK 500 ALA C 352 48.36 -91.25 REMARK 500 TYR C 421 -57.69 -134.67 REMARK 500 ASN C 856 -133.47 49.58 REMARK 500 ARG C 983 -70.18 -124.44 REMARK 500 ARG E 30 -125.14 53.84 REMARK 500 ASP E 50 -130.04 56.07 REMARK 500 PHE F 32 -130.39 55.85 REMARK 500 ASN F 122 -126.49 49.55 REMARK 500 THR F 124 -121.08 46.29 REMARK 500 LEU F 226 -65.09 -103.45 REMARK 500 PRO F 230 47.24 -84.64 REMARK 500 LYS F 304 15.58 53.64 REMARK 500 PRO F 337 48.41 -90.97 REMARK 500 ALA F 352 48.44 -91.27 REMARK 500 TYR F 421 -57.62 -134.70 REMARK 500 ASN F 856 -133.49 49.55 REMARK 500 ARG F 983 -70.24 -124.41 REMARK 500 ARG J 30 -125.18 53.98 REMARK 500 ASP J 50 -130.03 56.07 REMARK 500 PHE K 32 -130.46 55.88 REMARK 500 ASN K 122 -126.47 49.47 REMARK 500 THR K 124 -121.09 46.31 REMARK 500 LEU K 226 -65.03 -103.43 REMARK 500 PRO K 230 47.23 -84.71 REMARK 500 LYS K 304 15.62 53.64 REMARK 500 PRO K 337 48.43 -90.96 REMARK 500 ALA K 352 48.36 -91.29 REMARK 500 TYR K 421 -57.68 -134.69 REMARK 500 ASN K 856 -133.46 49.54 REMARK 500 ARG K 983 -70.27 -124.42 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-46892 RELATED DB: EMDB REMARK 900 STRUCTURE OF SARS-COV-2 SPIKE IN COMPLEX WITH ANTIBODY FAB COVIC-154 DBREF 9DHY A 1 123 PDB 9DHY 9DHY 1 123 DBREF 9DHY B 1 107 PDB 9DHY 9DHY 1 107 DBREF 9DHY C 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9DHY D 1 123 PDB 9DHY 9DHY 1 123 DBREF 9DHY E 1 107 PDB 9DHY 9DHY 1 107 DBREF 9DHY F 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9DHY I 1 123 PDB 9DHY 9DHY 1 123 DBREF 9DHY J 1 107 PDB 9DHY 9DHY 1 107 DBREF 9DHY K 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 SEQADV 9DHY MET C -3 UNP P0DTC2 INITIATING METHIONINE SEQADV 9DHY GLY C -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL C -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LYS C 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL C 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LEU C 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY PHE C 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA C 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LEU C 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ILE C 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY CYS C 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ILE C 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA C 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL C 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA C 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY GLU C 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA C 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY GLY C 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9DHY SER C 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9DHY SER C 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9DHY PRO C 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9DHY PRO C 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9DHY PRO C 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9DHY PRO C 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9DHY PRO C 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9DHY MET F -3 UNP P0DTC2 INITIATING METHIONINE SEQADV 9DHY GLY F -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL F -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LYS F 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL F 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LEU F 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY PHE F 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA F 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LEU F 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ILE F 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY CYS F 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ILE F 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA F 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL F 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA F 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY GLU F 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA F 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY GLY F 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9DHY SER F 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9DHY SER F 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9DHY PRO F 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9DHY PRO F 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9DHY PRO F 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9DHY PRO F 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9DHY PRO F 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9DHY MET K -3 UNP P0DTC2 INITIATING METHIONINE SEQADV 9DHY GLY K -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL K -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LYS K 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL K 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LEU K 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY PHE K 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA K 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY LEU K 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ILE K 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY CYS K 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ILE K 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA K 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY VAL K 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA K 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY GLU K 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY ALA K 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9DHY GLY K 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9DHY SER K 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9DHY SER K 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9DHY PRO K 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9DHY PRO K 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9DHY PRO K 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9DHY PRO K 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9DHY PRO K 987 UNP P0DTC2 VAL 987 CONFLICT SEQRES 1 A 123 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 A 123 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 A 123 PHE THR PHE ASP ASP TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 A 123 THR PRO GLY LYS GLY LEU GLU TRP VAL SER GLY ILE SER SEQRES 5 A 123 TRP ASN SER GLY SER ILE GLY TYR ALA ASP SER VAL LYS SEQRES 6 A 123 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 A 123 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 A 123 ALA LEU TYR TYR CYS THR LYS ASP LEU GLY LEU GLY ILE SEQRES 9 A 123 GLY PHE TYR TYR GLY LEU ASP VAL TRP GLY GLN GLY THR SEQRES 10 A 123 THR VAL THR VAL SER SER SEQRES 1 B 107 ALA ILE GLN MET THR GLN SER PRO SER SER LEU SER THR SEQRES 2 B 107 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 B 107 GLN GLY ILE ARG ASN ASP LEU GLY TRP TYR GLN LEU LYS SEQRES 4 B 107 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ASP ALA SER SEQRES 5 B 107 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 B 107 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 B 107 GLU PRO GLU ASP LEU ALA THR TYR TYR CYS LEU HIS HIS SEQRES 8 B 107 TYR THR TYR PRO TRP THR PHE GLY HIS GLY THR LYS VAL SEQRES 9 B 107 GLU LEU LYS SEQRES 1 C 1212 MET GLY VAL LYS VAL LEU PHE ALA LEU ILE CYS ILE ALA SEQRES 2 C 1212 VAL ALA GLU ALA GLN CYS VAL ASN LEU THR THR ARG THR SEQRES 3 C 1212 GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR ARG GLY SEQRES 4 C 1212 VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER VAL LEU SEQRES 5 C 1212 HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SER ASN SEQRES 6 C 1212 VAL THR TRP PHE HIS ALA ILE HIS VAL SER GLY THR ASN SEQRES 7 C 1212 GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN SEQRES 8 C 1212 ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE SEQRES 9 C 1212 ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS SEQRES 10 C 1212 THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL SEQRES 11 C 1212 VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO SEQRES 12 C 1212 PHE LEU GLY VAL TYR TYR HIS LYS ASN ASN LYS SER TRP SEQRES 13 C 1212 MET GLU SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN SEQRES 14 C 1212 CYS THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP SEQRES 15 C 1212 LEU GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU SEQRES 16 C 1212 PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SEQRES 17 C 1212 SER LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO SEQRES 18 C 1212 GLN GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO SEQRES 19 C 1212 ILE GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA SEQRES 20 C 1212 LEU HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER SEQRES 21 C 1212 GLY TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR SEQRES 22 C 1212 LEU GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN SEQRES 23 C 1212 GLY THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO SEQRES 24 C 1212 LEU SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL SEQRES 25 C 1212 GLU LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN SEQRES 26 C 1212 PRO THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN SEQRES 27 C 1212 LEU CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE SEQRES 28 C 1212 ALA SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN SEQRES 29 C 1212 CYS VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER SEQRES 30 C 1212 PHE SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS SEQRES 31 C 1212 LEU ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER SEQRES 32 C 1212 PHE VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO SEQRES 33 C 1212 GLY GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU SEQRES 34 C 1212 PRO ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER SEQRES 35 C 1212 ASN ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR SEQRES 36 C 1212 LEU TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE SEQRES 37 C 1212 GLU ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER SEQRES 38 C 1212 THR PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE SEQRES 39 C 1212 PRO LEU GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL SEQRES 40 C 1212 GLY TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU SEQRES 41 C 1212 LEU LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SEQRES 42 C 1212 SER THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN SEQRES 43 C 1212 PHE ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER SEQRES 44 C 1212 ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP SEQRES 45 C 1212 ILE ALA ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR SEQRES 46 C 1212 LEU GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY SEQRES 47 C 1212 VAL SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN SEQRES 48 C 1212 VAL ALA VAL LEU TYR GLN ASP VAL ASN CYS THR GLU VAL SEQRES 49 C 1212 PRO VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP SEQRES 50 C 1212 ARG VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG SEQRES 51 C 1212 ALA GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER SEQRES 52 C 1212 TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SEQRES 53 C 1212 SER TYR GLN THR GLN THR ASN SER PRO GLY SER ALA SER SEQRES 54 C 1212 SER VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER SEQRES 55 C 1212 LEU GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER SEQRES 56 C 1212 ILE ALA ILE PRO THR ASN PHE THR ILE SER VAL THR THR SEQRES 57 C 1212 GLU ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP SEQRES 58 C 1212 CYS THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER SEQRES 59 C 1212 ASN LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU SEQRES 60 C 1212 ASN ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS SEQRES 61 C 1212 ASN THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR SEQRES 62 C 1212 LYS THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SEQRES 63 C 1212 SER GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SEQRES 64 C 1212 SER PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU SEQRES 65 C 1212 ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU SEQRES 66 C 1212 GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS SEQRES 67 C 1212 PHE ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP SEQRES 68 C 1212 GLU MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY SEQRES 69 C 1212 THR ILE THR SER GLY TRP THR PHE GLY ALA GLY PRO ALA SEQRES 70 C 1212 LEU GLN ILE PRO PHE PRO MET GLN MET ALA TYR ARG PHE SEQRES 71 C 1212 ASN GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN SEQRES 72 C 1212 GLN LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY SEQRES 73 C 1212 LYS ILE GLN ASP SER LEU SER SER THR PRO SER ALA LEU SEQRES 74 C 1212 GLY LYS LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA SEQRES 75 C 1212 LEU ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY SEQRES 76 C 1212 ALA ILE SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU SEQRES 77 C 1212 ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE SEQRES 78 C 1212 THR GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN SEQRES 79 C 1212 GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN SEQRES 80 C 1212 LEU ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SEQRES 81 C 1212 SER LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU SEQRES 82 C 1212 MET SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE SEQRES 83 C 1212 LEU HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE SEQRES 84 C 1212 THR THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS SEQRES 85 C 1212 PHE PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS SEQRES 86 C 1212 TRP PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE SEQRES 87 C 1212 ILE THR THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP SEQRES 88 C 1212 VAL VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO SEQRES 89 C 1212 LEU GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP SEQRES 90 C 1212 LYS TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU SEQRES 91 C 1212 GLY ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE SEQRES 92 C 1212 GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN SEQRES 93 C 1212 LEU ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS SEQRES 94 C 1212 TYR GLU GLN SEQRES 1 D 123 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 D 123 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 D 123 PHE THR PHE ASP ASP TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 D 123 THR PRO GLY LYS GLY LEU GLU TRP VAL SER GLY ILE SER SEQRES 5 D 123 TRP ASN SER GLY SER ILE GLY TYR ALA ASP SER VAL LYS SEQRES 6 D 123 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 D 123 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 D 123 ALA LEU TYR TYR CYS THR LYS ASP LEU GLY LEU GLY ILE SEQRES 9 D 123 GLY PHE TYR TYR GLY LEU ASP VAL TRP GLY GLN GLY THR SEQRES 10 D 123 THR VAL THR VAL SER SER SEQRES 1 E 107 ALA ILE GLN MET THR GLN SER PRO SER SER LEU SER THR SEQRES 2 E 107 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 E 107 GLN GLY ILE ARG ASN ASP LEU GLY TRP TYR GLN LEU LYS SEQRES 4 E 107 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ASP ALA SER SEQRES 5 E 107 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 E 107 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 E 107 GLU PRO GLU ASP LEU ALA THR TYR TYR CYS LEU HIS HIS SEQRES 8 E 107 TYR THR TYR PRO TRP THR PHE GLY HIS GLY THR LYS VAL SEQRES 9 E 107 GLU LEU LYS SEQRES 1 F 1212 MET GLY VAL LYS VAL LEU PHE ALA LEU ILE CYS ILE ALA SEQRES 2 F 1212 VAL ALA GLU ALA GLN CYS VAL ASN LEU THR THR ARG THR SEQRES 3 F 1212 GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR ARG GLY SEQRES 4 F 1212 VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER VAL LEU SEQRES 5 F 1212 HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SER ASN SEQRES 6 F 1212 VAL THR TRP PHE HIS ALA ILE HIS VAL SER GLY THR ASN SEQRES 7 F 1212 GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN SEQRES 8 F 1212 ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE SEQRES 9 F 1212 ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS SEQRES 10 F 1212 THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL SEQRES 11 F 1212 VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO SEQRES 12 F 1212 PHE LEU GLY VAL TYR TYR HIS LYS ASN ASN LYS SER TRP SEQRES 13 F 1212 MET GLU SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN SEQRES 14 F 1212 CYS THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP SEQRES 15 F 1212 LEU GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU SEQRES 16 F 1212 PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SEQRES 17 F 1212 SER LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO SEQRES 18 F 1212 GLN GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO SEQRES 19 F 1212 ILE GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA SEQRES 20 F 1212 LEU HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER SEQRES 21 F 1212 GLY TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR SEQRES 22 F 1212 LEU GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN SEQRES 23 F 1212 GLY THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO SEQRES 24 F 1212 LEU SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL SEQRES 25 F 1212 GLU LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN SEQRES 26 F 1212 PRO THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN SEQRES 27 F 1212 LEU CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE SEQRES 28 F 1212 ALA SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN SEQRES 29 F 1212 CYS VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER SEQRES 30 F 1212 PHE SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS SEQRES 31 F 1212 LEU ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER SEQRES 32 F 1212 PHE VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO SEQRES 33 F 1212 GLY GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU SEQRES 34 F 1212 PRO ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER SEQRES 35 F 1212 ASN ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR SEQRES 36 F 1212 LEU TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE SEQRES 37 F 1212 GLU ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER SEQRES 38 F 1212 THR PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE SEQRES 39 F 1212 PRO LEU GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL SEQRES 40 F 1212 GLY TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU SEQRES 41 F 1212 LEU LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SEQRES 42 F 1212 SER THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN SEQRES 43 F 1212 PHE ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER SEQRES 44 F 1212 ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP SEQRES 45 F 1212 ILE ALA ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR SEQRES 46 F 1212 LEU GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY SEQRES 47 F 1212 VAL SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN SEQRES 48 F 1212 VAL ALA VAL LEU TYR GLN ASP VAL ASN CYS THR GLU VAL SEQRES 49 F 1212 PRO VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP SEQRES 50 F 1212 ARG VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG SEQRES 51 F 1212 ALA GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER SEQRES 52 F 1212 TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SEQRES 53 F 1212 SER TYR GLN THR GLN THR ASN SER PRO GLY SER ALA SER SEQRES 54 F 1212 SER VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER SEQRES 55 F 1212 LEU GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER SEQRES 56 F 1212 ILE ALA ILE PRO THR ASN PHE THR ILE SER VAL THR THR SEQRES 57 F 1212 GLU ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP SEQRES 58 F 1212 CYS THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER SEQRES 59 F 1212 ASN LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU SEQRES 60 F 1212 ASN ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS SEQRES 61 F 1212 ASN THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR SEQRES 62 F 1212 LYS THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SEQRES 63 F 1212 SER GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SEQRES 64 F 1212 SER PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU SEQRES 65 F 1212 ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU SEQRES 66 F 1212 GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS SEQRES 67 F 1212 PHE ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP SEQRES 68 F 1212 GLU MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY SEQRES 69 F 1212 THR ILE THR SER GLY TRP THR PHE GLY ALA GLY PRO ALA SEQRES 70 F 1212 LEU GLN ILE PRO PHE PRO MET GLN MET ALA TYR ARG PHE SEQRES 71 F 1212 ASN GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN SEQRES 72 F 1212 GLN LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY SEQRES 73 F 1212 LYS ILE GLN ASP SER LEU SER SER THR PRO SER ALA LEU SEQRES 74 F 1212 GLY LYS LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA SEQRES 75 F 1212 LEU ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY SEQRES 76 F 1212 ALA ILE SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU SEQRES 77 F 1212 ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE SEQRES 78 F 1212 THR GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN SEQRES 79 F 1212 GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN SEQRES 80 F 1212 LEU ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SEQRES 81 F 1212 SER LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU SEQRES 82 F 1212 MET SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE SEQRES 83 F 1212 LEU HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE SEQRES 84 F 1212 THR THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS SEQRES 85 F 1212 PHE PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS SEQRES 86 F 1212 TRP PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE SEQRES 87 F 1212 ILE THR THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP SEQRES 88 F 1212 VAL VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO SEQRES 89 F 1212 LEU GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP SEQRES 90 F 1212 LYS TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU SEQRES 91 F 1212 GLY ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE SEQRES 92 F 1212 GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN SEQRES 93 F 1212 LEU ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS SEQRES 94 F 1212 TYR GLU GLN SEQRES 1 I 123 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 I 123 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 I 123 PHE THR PHE ASP ASP TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 I 123 THR PRO GLY LYS GLY LEU GLU TRP VAL SER GLY ILE SER SEQRES 5 I 123 TRP ASN SER GLY SER ILE GLY TYR ALA ASP SER VAL LYS SEQRES 6 I 123 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 I 123 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 I 123 ALA LEU TYR TYR CYS THR LYS ASP LEU GLY LEU GLY ILE SEQRES 9 I 123 GLY PHE TYR TYR GLY LEU ASP VAL TRP GLY GLN GLY THR SEQRES 10 I 123 THR VAL THR VAL SER SER SEQRES 1 J 107 ALA ILE GLN MET THR GLN SER PRO SER SER LEU SER THR SEQRES 2 J 107 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 J 107 GLN GLY ILE ARG ASN ASP LEU GLY TRP TYR GLN LEU LYS SEQRES 4 J 107 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ASP ALA SER SEQRES 5 J 107 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 J 107 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 J 107 GLU PRO GLU ASP LEU ALA THR TYR TYR CYS LEU HIS HIS SEQRES 8 J 107 TYR THR TYR PRO TRP THR PHE GLY HIS GLY THR LYS VAL SEQRES 9 J 107 GLU LEU LYS SEQRES 1 K 1212 MET GLY VAL LYS VAL LEU PHE ALA LEU ILE CYS ILE ALA SEQRES 2 K 1212 VAL ALA GLU ALA GLN CYS VAL ASN LEU THR THR ARG THR SEQRES 3 K 1212 GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR ARG GLY SEQRES 4 K 1212 VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER VAL LEU SEQRES 5 K 1212 HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SER ASN SEQRES 6 K 1212 VAL THR TRP PHE HIS ALA ILE HIS VAL SER GLY THR ASN SEQRES 7 K 1212 GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN SEQRES 8 K 1212 ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE SEQRES 9 K 1212 ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS SEQRES 10 K 1212 THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL SEQRES 11 K 1212 VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO SEQRES 12 K 1212 PHE LEU GLY VAL TYR TYR HIS LYS ASN ASN LYS SER TRP SEQRES 13 K 1212 MET GLU SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN SEQRES 14 K 1212 CYS THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP SEQRES 15 K 1212 LEU GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU SEQRES 16 K 1212 PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SEQRES 17 K 1212 SER LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO SEQRES 18 K 1212 GLN GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO SEQRES 19 K 1212 ILE GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA SEQRES 20 K 1212 LEU HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER SEQRES 21 K 1212 GLY TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR SEQRES 22 K 1212 LEU GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN SEQRES 23 K 1212 GLY THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO SEQRES 24 K 1212 LEU SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL SEQRES 25 K 1212 GLU LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN SEQRES 26 K 1212 PRO THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN SEQRES 27 K 1212 LEU CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE SEQRES 28 K 1212 ALA SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN SEQRES 29 K 1212 CYS VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER SEQRES 30 K 1212 PHE SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS SEQRES 31 K 1212 LEU ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER SEQRES 32 K 1212 PHE VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO SEQRES 33 K 1212 GLY GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU SEQRES 34 K 1212 PRO ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER SEQRES 35 K 1212 ASN ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR SEQRES 36 K 1212 LEU TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE SEQRES 37 K 1212 GLU ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER SEQRES 38 K 1212 THR PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE SEQRES 39 K 1212 PRO LEU GLN SER TYR GLY PHE GLN PRO THR ASN GLY VAL SEQRES 40 K 1212 GLY TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU SEQRES 41 K 1212 LEU LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SEQRES 42 K 1212 SER THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN SEQRES 43 K 1212 PHE ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER SEQRES 44 K 1212 ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP SEQRES 45 K 1212 ILE ALA ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR SEQRES 46 K 1212 LEU GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY SEQRES 47 K 1212 VAL SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN SEQRES 48 K 1212 VAL ALA VAL LEU TYR GLN ASP VAL ASN CYS THR GLU VAL SEQRES 49 K 1212 PRO VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP SEQRES 50 K 1212 ARG VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG SEQRES 51 K 1212 ALA GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER SEQRES 52 K 1212 TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SEQRES 53 K 1212 SER TYR GLN THR GLN THR ASN SER PRO GLY SER ALA SER SEQRES 54 K 1212 SER VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER SEQRES 55 K 1212 LEU GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER SEQRES 56 K 1212 ILE ALA ILE PRO THR ASN PHE THR ILE SER VAL THR THR SEQRES 57 K 1212 GLU ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP SEQRES 58 K 1212 CYS THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER SEQRES 59 K 1212 ASN LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU SEQRES 60 K 1212 ASN ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS SEQRES 61 K 1212 ASN THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR SEQRES 62 K 1212 LYS THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SEQRES 63 K 1212 SER GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SEQRES 64 K 1212 SER PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU SEQRES 65 K 1212 ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU SEQRES 66 K 1212 GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS SEQRES 67 K 1212 PHE ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP SEQRES 68 K 1212 GLU MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY SEQRES 69 K 1212 THR ILE THR SER GLY TRP THR PHE GLY ALA GLY PRO ALA SEQRES 70 K 1212 LEU GLN ILE PRO PHE PRO MET GLN MET ALA TYR ARG PHE SEQRES 71 K 1212 ASN GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN SEQRES 72 K 1212 GLN LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY SEQRES 73 K 1212 LYS ILE GLN ASP SER LEU SER SER THR PRO SER ALA LEU SEQRES 74 K 1212 GLY LYS LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA SEQRES 75 K 1212 LEU ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY SEQRES 76 K 1212 ALA ILE SER SER VAL LEU ASN ASP ILE LEU SER ARG LEU SEQRES 77 K 1212 ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE SEQRES 78 K 1212 THR GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN SEQRES 79 K 1212 GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN SEQRES 80 K 1212 LEU ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SEQRES 81 K 1212 SER LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU SEQRES 82 K 1212 MET SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE SEQRES 83 K 1212 LEU HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE SEQRES 84 K 1212 THR THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS SEQRES 85 K 1212 PHE PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS SEQRES 86 K 1212 TRP PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE SEQRES 87 K 1212 ILE THR THR ASP ASN THR PHE VAL SER GLY ASN CYS ASP SEQRES 88 K 1212 VAL VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO SEQRES 89 K 1212 LEU GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP SEQRES 90 K 1212 LYS TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU SEQRES 91 K 1212 GLY ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE SEQRES 92 K 1212 GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN SEQRES 93 K 1212 LEU ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS SEQRES 94 K 1212 TYR GLU GLN HET NAG M 1 14 HET NAG M 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG H 1 14 HET NAG H 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG L 1 14 HET NAG L 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HET NAG C1307 14 HET NAG F1301 14 HET NAG F1302 14 HET NAG F1303 14 HET NAG F1304 14 HET NAG F1305 14 HET NAG F1306 14 HET NAG F1307 14 HET NAG K1301 14 HET NAG K1302 14 HET NAG K1303 14 HET NAG K1304 14 HET NAG K1305 14 HET NAG K1306 14 HET NAG K1307 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 10 NAG 39(C8 H15 N O6) HELIX 1 AA1 THR A 28 TYR A 32 5 5 HELIX 2 AA2 ARG A 87 THR A 91 5 5 HELIX 3 AA3 ASP C 294 LYS C 304 1 11 HELIX 4 AA4 PRO C 337 ASN C 343 1 7 HELIX 5 AA5 ASP C 364 SER C 371 1 8 HELIX 6 AA6 SER C 383 ASN C 388 1 6 HELIX 7 AA7 ASP C 405 ALA C 411 1 7 HELIX 8 AA8 GLY C 416 TYR C 421 1 6 HELIX 9 AA9 SER C 438 SER C 443 1 6 HELIX 10 AB1 ASP C 737 CYS C 743 1 7 HELIX 11 AB2 SER C 746 LEU C 754 1 9 HELIX 12 AB3 GLY C 757 ALA C 783 1 27 HELIX 13 AB4 SER C 816 VAL C 826 1 11 HELIX 14 AB5 THR C 866 GLY C 885 1 20 HELIX 15 AB6 PRO C 897 GLY C 910 1 14 HELIX 16 AB7 THR C 912 ASN C 919 1 8 HELIX 17 AB8 ASN C 919 THR C 941 1 23 HELIX 18 AB9 PRO C 942 ALA C 944 5 3 HELIX 19 AC1 LEU C 945 GLN C 965 1 21 HELIX 20 AC2 LEU C 966 SER C 968 5 3 HELIX 21 AC3 VAL C 976 LEU C 984 1 9 HELIX 22 AC4 ASP C 985 CYS C 1032 1 48 HELIX 23 AC5 PRO C 1140 LEU C 1145 1 6 HELIX 24 AC6 THR D 28 TYR D 32 5 5 HELIX 25 AC7 ARG D 87 THR D 91 5 5 HELIX 26 AC8 ASP F 294 LYS F 304 1 11 HELIX 27 AC9 PRO F 337 ASN F 343 1 7 HELIX 28 AD1 ASP F 364 SER F 371 1 8 HELIX 29 AD2 SER F 383 ASN F 388 1 6 HELIX 30 AD3 ASP F 405 ALA F 411 1 7 HELIX 31 AD4 GLY F 416 TYR F 421 1 6 HELIX 32 AD5 SER F 438 SER F 443 1 6 HELIX 33 AD6 ASP F 737 CYS F 743 1 7 HELIX 34 AD7 SER F 746 LEU F 754 1 9 HELIX 35 AD8 GLY F 757 ALA F 783 1 27 HELIX 36 AD9 SER F 816 VAL F 826 1 11 HELIX 37 AE1 THR F 866 GLY F 885 1 20 HELIX 38 AE2 PRO F 897 GLY F 910 1 14 HELIX 39 AE3 THR F 912 ASN F 919 1 8 HELIX 40 AE4 ASN F 919 THR F 941 1 23 HELIX 41 AE5 PRO F 942 ALA F 944 5 3 HELIX 42 AE6 LEU F 945 GLN F 965 1 21 HELIX 43 AE7 LEU F 966 SER F 968 5 3 HELIX 44 AE8 VAL F 976 LEU F 984 1 9 HELIX 45 AE9 ASP F 985 CYS F 1032 1 48 HELIX 46 AF1 PRO F 1140 LEU F 1145 1 6 HELIX 47 AF2 THR I 28 TYR I 32 5 5 HELIX 48 AF3 ARG I 87 THR I 91 5 5 HELIX 49 AF4 ASP K 294 LYS K 304 1 11 HELIX 50 AF5 PRO K 337 ASN K 343 1 7 HELIX 51 AF6 ASP K 364 SER K 371 1 8 HELIX 52 AF7 SER K 383 ASN K 388 1 6 HELIX 53 AF8 ASP K 405 ALA K 411 1 7 HELIX 54 AF9 GLY K 416 TYR K 421 1 6 HELIX 55 AG1 SER K 438 SER K 443 1 6 HELIX 56 AG2 ASP K 737 CYS K 743 1 7 HELIX 57 AG3 SER K 746 LEU K 754 1 9 HELIX 58 AG4 GLY K 757 ALA K 783 1 27 HELIX 59 AG5 SER K 816 VAL K 826 1 11 HELIX 60 AG6 THR K 866 GLY K 885 1 20 HELIX 61 AG7 PRO K 897 GLY K 910 1 14 HELIX 62 AG8 THR K 912 ASN K 919 1 8 HELIX 63 AG9 ASN K 919 THR K 941 1 23 HELIX 64 AH1 PRO K 942 ALA K 944 5 3 HELIX 65 AH2 LEU K 945 GLN K 965 1 21 HELIX 66 AH3 LEU K 966 SER K 968 5 3 HELIX 67 AH4 VAL K 976 LEU K 984 1 9 HELIX 68 AH5 ASP K 985 CYS K 1032 1 48 HELIX 69 AH6 PRO K 1140 LEU K 1145 1 6 SHEET 1 AA1 4 GLN A 3 SER A 7 0 SHEET 2 AA1 4 LEU A 18 SER A 25 -1 O ALA A 23 N VAL A 5 SHEET 3 AA1 4 SER A 78 MET A 83 -1 O MET A 83 N LEU A 18 SHEET 4 AA1 4 PHE A 68 ASP A 73 -1 N SER A 71 O TYR A 80 SHEET 1 AA2 6 LEU A 11 VAL A 12 0 SHEET 2 AA2 6 THR A 117 VAL A 121 1 O THR A 120 N VAL A 12 SHEET 3 AA2 6 ALA A 92 ASP A 99 -1 N TYR A 94 O THR A 117 SHEET 4 AA2 6 MET A 34 GLN A 39 -1 N VAL A 37 O TYR A 95 SHEET 5 AA2 6 LEU A 45 ILE A 51 -1 O VAL A 48 N TRP A 36 SHEET 6 AA2 6 ILE A 58 TYR A 60 -1 O GLY A 59 N GLY A 50 SHEET 1 AA3 4 LEU A 11 VAL A 12 0 SHEET 2 AA3 4 THR A 117 VAL A 121 1 O THR A 120 N VAL A 12 SHEET 3 AA3 4 ALA A 92 ASP A 99 -1 N TYR A 94 O THR A 117 SHEET 4 AA3 4 LEU A 110 TRP A 113 -1 O VAL A 112 N LYS A 98 SHEET 1 AA4 4 MET B 4 SER B 7 0 SHEET 2 AA4 4 VAL B 19 ALA B 25 -1 O ARG B 24 N THR B 5 SHEET 3 AA4 4 ASP B 70 ILE B 75 -1 O PHE B 71 N CYS B 23 SHEET 4 AA4 4 PHE B 62 SER B 67 -1 N SER B 65 O THR B 72 SHEET 1 AA5 6 SER B 10 THR B 13 0 SHEET 2 AA5 6 THR B 102 LEU B 106 1 O LYS B 103 N LEU B 11 SHEET 3 AA5 6 THR B 85 HIS B 90 -1 N TYR B 86 O THR B 102 SHEET 4 AA5 6 LEU B 33 LEU B 38 -1 N TYR B 36 O TYR B 87 SHEET 5 AA5 6 LYS B 45 TYR B 49 -1 O LYS B 45 N GLN B 37 SHEET 6 AA5 6 THR B 53 LEU B 54 -1 O THR B 53 N TYR B 49 SHEET 1 AA6 8 THR C 29 ASN C 30 0 SHEET 2 AA6 8 ASN C 61 PHE C 65 -1 O VAL C 62 N THR C 29 SHEET 3 AA6 8 TYR C 265 TYR C 269 -1 O TYR C 265 N PHE C 65 SHEET 4 AA6 8 VAL C 90 SER C 94 -1 N TYR C 91 O GLY C 268 SHEET 5 AA6 8 LEU C 189 ILE C 197 -1 O PHE C 192 N PHE C 92 SHEET 6 AA6 8 TYR C 200 THR C 208 -1 O LYS C 206 N GLU C 191 SHEET 7 AA6 8 ALA C 222 LEU C 229 -1 O LEU C 226 N ILE C 203 SHEET 8 AA6 8 VAL C 36 TYR C 37 1 N VAL C 36 O LEU C 223 SHEET 1 AA7 3 LEU C 48 THR C 51 0 SHEET 2 AA7 3 PHE C 275 TYR C 279 -1 O PHE C 275 N THR C 51 SHEET 3 AA7 3 ILE C 285 ASP C 290 -1 O ASP C 287 N LYS C 278 SHEET 1 AA8 6 LEU C 84 PRO C 85 0 SHEET 2 AA8 6 ARG C 237 LEU C 241 -1 O PHE C 238 N LEU C 84 SHEET 3 AA8 6 GLY C 103 GLY C 107 -1 N GLY C 107 O ARG C 237 SHEET 4 AA8 6 LEU C 117 VAL C 120 -1 O ILE C 119 N TRP C 104 SHEET 5 AA8 6 VAL C 126 LYS C 129 -1 O LYS C 129 N LEU C 118 SHEET 6 AA8 6 GLU C 169 GLN C 173 -1 O GLN C 173 N VAL C 126 SHEET 1 AA9 5 GLY C 311 ARG C 319 0 SHEET 2 AA9 5 PHE C 592 THR C 599 -1 O VAL C 597 N TYR C 313 SHEET 3 AA9 5 ALA C 609 GLN C 613 -1 O ALA C 609 N ILE C 598 SHEET 4 AA9 5 GLY C 648 ILE C 651 -1 O CYS C 649 N TYR C 612 SHEET 5 AA9 5 VAL C 642 GLN C 644 -1 N PHE C 643 O LEU C 650 SHEET 1 AB1 6 SER C 325 ARG C 328 0 SHEET 2 AB1 6 CYS C 538 PHE C 543 1 O ASN C 540 N ILE C 326 SHEET 3 AB1 6 LEU C 546 GLU C 554 -1 O GLY C 548 N PHE C 541 SHEET 4 AB1 6 ILE C 584 THR C 588 -1 O THR C 588 N VAL C 551 SHEET 5 AB1 6 THR C 573 ARG C 577 -1 N VAL C 576 O LEU C 585 SHEET 6 AB1 6 PHE C 565 ARG C 567 -1 N GLY C 566 O ALA C 575 SHEET 1 AB2 5 ASN C 354 ILE C 358 0 SHEET 2 AB2 5 VAL C 395 ARG C 403 -1 O VAL C 395 N ILE C 358 SHEET 3 AB2 5 PRO C 507 PHE C 515 -1 O TYR C 508 N ILE C 402 SHEET 4 AB2 5 VAL C 433 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AB2 5 PHE C 374 THR C 376 -1 N THR C 376 O ALA C 435 SHEET 1 AB3 4 GLU C 654 HIS C 655 0 SHEET 2 AB3 4 ILE C 692 THR C 696 1 O ILE C 692 N GLU C 654 SHEET 3 AB3 4 ILE C 670 TYR C 674 -1 N SER C 673 O ILE C 693 SHEET 4 AB3 4 ILE C 664 GLY C 667 -1 N ILE C 666 O ILE C 670 SHEET 1 AB4 2 ALA C 701 GLU C 702 0 SHEET 2 AB4 2 GLN F 787 ILE F 788 1 O ILE F 788 N ALA C 701 SHEET 1 AB5 3 SER C 711 PRO C 728 0 SHEET 2 AB5 3 GLY C1059 ALA C1078 -1 O PHE C1075 N ILE C 712 SHEET 3 AB5 3 TYR C1047 ALA C1056 -1 N MET C1050 O VAL C1065 SHEET 1 AB6 5 SER C 711 PRO C 728 0 SHEET 2 AB6 5 GLY C1059 ALA C1078 -1 O PHE C1075 N ILE C 712 SHEET 3 AB6 5 VAL C1094 ASN C1098 -1 O SER C1097 N THR C1076 SHEET 4 AB6 5 HIS C1101 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 5 AB6 5 GLN C1113 ILE C1114 -1 O GLN C1113 N VAL C1104 SHEET 1 AB7 2 LYS C 733 VAL C 736 0 SHEET 2 AB7 2 LEU C 858 LEU C 861 -1 O THR C 859 N SER C 735 SHEET 1 AB8 2 GLN C 787 ILE C 788 0 SHEET 2 AB8 2 ALA K 701 GLU K 702 1 O ALA K 701 N ILE C 788 SHEET 1 AB9 4 THR C1120 GLY C1124 0 SHEET 2 AB9 4 LYS C1086 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AB9 4 ILE C1081 HIS C1083 -1 N HIS C1083 O LYS C1086 SHEET 4 AB9 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AC1 4 GLN D 3 SER D 7 0 SHEET 2 AC1 4 LEU D 18 SER D 25 -1 O ALA D 23 N VAL D 5 SHEET 3 AC1 4 SER D 78 MET D 83 -1 O MET D 83 N LEU D 18 SHEET 4 AC1 4 PHE D 68 ASP D 73 -1 N SER D 71 O TYR D 80 SHEET 1 AC2 6 LEU D 11 VAL D 12 0 SHEET 2 AC2 6 THR D 117 VAL D 121 1 O THR D 120 N VAL D 12 SHEET 3 AC2 6 ALA D 92 ASP D 99 -1 N TYR D 94 O THR D 117 SHEET 4 AC2 6 MET D 34 GLN D 39 -1 N VAL D 37 O TYR D 95 SHEET 5 AC2 6 LEU D 45 ILE D 51 -1 O VAL D 48 N TRP D 36 SHEET 6 AC2 6 ILE D 58 TYR D 60 -1 O GLY D 59 N GLY D 50 SHEET 1 AC3 4 LEU D 11 VAL D 12 0 SHEET 2 AC3 4 THR D 117 VAL D 121 1 O THR D 120 N VAL D 12 SHEET 3 AC3 4 ALA D 92 ASP D 99 -1 N TYR D 94 O THR D 117 SHEET 4 AC3 4 LEU D 110 TRP D 113 -1 O VAL D 112 N LYS D 98 SHEET 1 AC4 4 MET E 4 SER E 7 0 SHEET 2 AC4 4 VAL E 19 ALA E 25 -1 O ARG E 24 N THR E 5 SHEET 3 AC4 4 ASP E 70 ILE E 75 -1 O PHE E 71 N CYS E 23 SHEET 4 AC4 4 PHE E 62 SER E 67 -1 N SER E 65 O THR E 72 SHEET 1 AC5 6 SER E 10 THR E 13 0 SHEET 2 AC5 6 THR E 102 LEU E 106 1 O LYS E 103 N LEU E 11 SHEET 3 AC5 6 THR E 85 HIS E 90 -1 N TYR E 86 O THR E 102 SHEET 4 AC5 6 LEU E 33 LEU E 38 -1 N TYR E 36 O TYR E 87 SHEET 5 AC5 6 LYS E 45 TYR E 49 -1 O LYS E 45 N GLN E 37 SHEET 6 AC5 6 THR E 53 LEU E 54 -1 O THR E 53 N TYR E 49 SHEET 1 AC6 8 THR F 29 ASN F 30 0 SHEET 2 AC6 8 ASN F 61 PHE F 65 -1 O VAL F 62 N THR F 29 SHEET 3 AC6 8 TYR F 265 TYR F 269 -1 O TYR F 265 N PHE F 65 SHEET 4 AC6 8 VAL F 90 SER F 94 -1 N TYR F 91 O GLY F 268 SHEET 5 AC6 8 LEU F 189 ILE F 197 -1 O PHE F 192 N PHE F 92 SHEET 6 AC6 8 TYR F 200 THR F 208 -1 O LYS F 206 N GLU F 191 SHEET 7 AC6 8 ALA F 222 LEU F 229 -1 O LEU F 226 N ILE F 203 SHEET 8 AC6 8 VAL F 36 TYR F 37 1 N VAL F 36 O LEU F 223 SHEET 1 AC7 3 LEU F 48 THR F 51 0 SHEET 2 AC7 3 PHE F 275 TYR F 279 -1 O PHE F 275 N THR F 51 SHEET 3 AC7 3 ILE F 285 ASP F 290 -1 O ASP F 287 N LYS F 278 SHEET 1 AC8 6 LEU F 84 PRO F 85 0 SHEET 2 AC8 6 ARG F 237 LEU F 241 -1 O PHE F 238 N LEU F 84 SHEET 3 AC8 6 GLY F 103 GLY F 107 -1 N GLY F 107 O ARG F 237 SHEET 4 AC8 6 LEU F 117 VAL F 120 -1 O ILE F 119 N TRP F 104 SHEET 5 AC8 6 VAL F 126 LYS F 129 -1 O LYS F 129 N LEU F 118 SHEET 6 AC8 6 GLU F 169 GLN F 173 -1 O GLN F 173 N VAL F 126 SHEET 1 AC9 5 GLY F 311 ARG F 319 0 SHEET 2 AC9 5 PHE F 592 THR F 599 -1 O VAL F 597 N TYR F 313 SHEET 3 AC9 5 ALA F 609 GLN F 613 -1 O ALA F 609 N ILE F 598 SHEET 4 AC9 5 GLY F 648 ILE F 651 -1 O CYS F 649 N TYR F 612 SHEET 5 AC9 5 VAL F 642 GLN F 644 -1 N PHE F 643 O LEU F 650 SHEET 1 AD1 6 SER F 325 ARG F 328 0 SHEET 2 AD1 6 CYS F 538 PHE F 543 1 O ASN F 540 N ILE F 326 SHEET 3 AD1 6 LEU F 546 GLU F 554 -1 O GLY F 548 N PHE F 541 SHEET 4 AD1 6 ILE F 584 THR F 588 -1 O THR F 588 N VAL F 551 SHEET 5 AD1 6 THR F 573 ARG F 577 -1 N VAL F 576 O LEU F 585 SHEET 6 AD1 6 PHE F 565 ARG F 567 -1 N GLY F 566 O ALA F 575 SHEET 1 AD2 5 ASN F 354 ILE F 358 0 SHEET 2 AD2 5 VAL F 395 ARG F 403 -1 O VAL F 395 N ILE F 358 SHEET 3 AD2 5 PRO F 507 PHE F 515 -1 O TYR F 508 N ILE F 402 SHEET 4 AD2 5 VAL F 433 ASN F 437 -1 N ILE F 434 O VAL F 511 SHEET 5 AD2 5 PHE F 374 THR F 376 -1 N THR F 376 O ALA F 435 SHEET 1 AD3 4 GLU F 654 HIS F 655 0 SHEET 2 AD3 4 ILE F 692 THR F 696 1 O ILE F 692 N GLU F 654 SHEET 3 AD3 4 ILE F 670 TYR F 674 -1 N SER F 673 O ILE F 693 SHEET 4 AD3 4 ILE F 664 GLY F 667 -1 N ILE F 666 O ILE F 670 SHEET 1 AD4 2 ALA F 701 GLU F 702 0 SHEET 2 AD4 2 GLN K 787 ILE K 788 1 O ILE K 788 N ALA F 701 SHEET 1 AD5 3 SER F 711 PRO F 728 0 SHEET 2 AD5 3 GLY F1059 ALA F1078 -1 O PHE F1075 N ILE F 712 SHEET 3 AD5 3 TYR F1047 ALA F1056 -1 N MET F1050 O VAL F1065 SHEET 1 AD6 5 SER F 711 PRO F 728 0 SHEET 2 AD6 5 GLY F1059 ALA F1078 -1 O PHE F1075 N ILE F 712 SHEET 3 AD6 5 VAL F1094 ASN F1098 -1 O SER F1097 N THR F1076 SHEET 4 AD6 5 HIS F1101 THR F1105 -1 O PHE F1103 N VAL F1096 SHEET 5 AD6 5 GLN F1113 ILE F1114 -1 O GLN F1113 N VAL F1104 SHEET 1 AD7 2 LYS F 733 VAL F 736 0 SHEET 2 AD7 2 LEU F 858 LEU F 861 -1 O THR F 859 N SER F 735 SHEET 1 AD8 4 THR F1120 GLY F1124 0 SHEET 2 AD8 4 LYS F1086 PRO F1090 -1 N PHE F1089 O PHE F1121 SHEET 3 AD8 4 ILE F1081 HIS F1083 -1 N HIS F1083 O LYS F1086 SHEET 4 AD8 4 VAL F1133 ASN F1134 1 O VAL F1133 N CYS F1082 SHEET 1 AD9 4 GLN I 3 SER I 7 0 SHEET 2 AD9 4 LEU I 18 SER I 25 -1 O ALA I 23 N VAL I 5 SHEET 3 AD9 4 SER I 78 MET I 83 -1 O MET I 83 N LEU I 18 SHEET 4 AD9 4 PHE I 68 ASP I 73 -1 N SER I 71 O TYR I 80 SHEET 1 AE1 6 LEU I 11 VAL I 12 0 SHEET 2 AE1 6 THR I 117 VAL I 121 1 O THR I 120 N VAL I 12 SHEET 3 AE1 6 ALA I 92 ASP I 99 -1 N TYR I 94 O THR I 117 SHEET 4 AE1 6 MET I 34 GLN I 39 -1 N VAL I 37 O TYR I 95 SHEET 5 AE1 6 LEU I 45 ILE I 51 -1 O VAL I 48 N TRP I 36 SHEET 6 AE1 6 ILE I 58 TYR I 60 -1 O GLY I 59 N GLY I 50 SHEET 1 AE2 4 LEU I 11 VAL I 12 0 SHEET 2 AE2 4 THR I 117 VAL I 121 1 O THR I 120 N VAL I 12 SHEET 3 AE2 4 ALA I 92 ASP I 99 -1 N TYR I 94 O THR I 117 SHEET 4 AE2 4 LEU I 110 TRP I 113 -1 O VAL I 112 N LYS I 98 SHEET 1 AE3 4 MET J 4 SER J 7 0 SHEET 2 AE3 4 VAL J 19 ALA J 25 -1 O ARG J 24 N THR J 5 SHEET 3 AE3 4 ASP J 70 ILE J 75 -1 O PHE J 71 N CYS J 23 SHEET 4 AE3 4 PHE J 62 SER J 67 -1 N SER J 65 O THR J 72 SHEET 1 AE4 6 SER J 10 THR J 13 0 SHEET 2 AE4 6 THR J 102 LEU J 106 1 O LYS J 103 N LEU J 11 SHEET 3 AE4 6 THR J 85 HIS J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AE4 6 LEU J 33 LEU J 38 -1 N TYR J 36 O TYR J 87 SHEET 5 AE4 6 LYS J 45 TYR J 49 -1 O LYS J 45 N GLN J 37 SHEET 6 AE4 6 THR J 53 LEU J 54 -1 O THR J 53 N TYR J 49 SHEET 1 AE5 8 THR K 29 ASN K 30 0 SHEET 2 AE5 8 ASN K 61 PHE K 65 -1 O VAL K 62 N THR K 29 SHEET 3 AE5 8 TYR K 265 TYR K 269 -1 O TYR K 265 N PHE K 65 SHEET 4 AE5 8 VAL K 90 SER K 94 -1 N TYR K 91 O GLY K 268 SHEET 5 AE5 8 LEU K 189 ILE K 197 -1 O PHE K 192 N PHE K 92 SHEET 6 AE5 8 TYR K 200 THR K 208 -1 O LYS K 206 N GLU K 191 SHEET 7 AE5 8 ALA K 222 LEU K 229 -1 O LEU K 226 N ILE K 203 SHEET 8 AE5 8 VAL K 36 TYR K 37 1 N VAL K 36 O LEU K 223 SHEET 1 AE6 3 LEU K 48 THR K 51 0 SHEET 2 AE6 3 PHE K 275 TYR K 279 -1 O PHE K 275 N THR K 51 SHEET 3 AE6 3 ILE K 285 ASP K 290 -1 O ASP K 287 N LYS K 278 SHEET 1 AE7 6 LEU K 84 PRO K 85 0 SHEET 2 AE7 6 ARG K 237 LEU K 241 -1 O PHE K 238 N LEU K 84 SHEET 3 AE7 6 GLY K 103 GLY K 107 -1 N GLY K 107 O ARG K 237 SHEET 4 AE7 6 LEU K 117 VAL K 120 -1 O ILE K 119 N TRP K 104 SHEET 5 AE7 6 VAL K 126 LYS K 129 -1 O LYS K 129 N LEU K 118 SHEET 6 AE7 6 GLU K 169 GLN K 173 -1 O GLN K 173 N VAL K 126 SHEET 1 AE8 5 GLY K 311 ARG K 319 0 SHEET 2 AE8 5 PHE K 592 THR K 599 -1 O VAL K 597 N TYR K 313 SHEET 3 AE8 5 ALA K 609 GLN K 613 -1 O ALA K 609 N ILE K 598 SHEET 4 AE8 5 GLY K 648 ILE K 651 -1 O CYS K 649 N TYR K 612 SHEET 5 AE8 5 VAL K 642 GLN K 644 -1 N PHE K 643 O LEU K 650 SHEET 1 AE9 6 SER K 325 ARG K 328 0 SHEET 2 AE9 6 CYS K 538 PHE K 543 1 O ASN K 540 N ILE K 326 SHEET 3 AE9 6 LEU K 546 GLU K 554 -1 O GLY K 548 N PHE K 541 SHEET 4 AE9 6 ILE K 584 THR K 588 -1 O THR K 588 N VAL K 551 SHEET 5 AE9 6 THR K 573 ARG K 577 -1 N VAL K 576 O LEU K 585 SHEET 6 AE9 6 PHE K 565 ARG K 567 -1 N GLY K 566 O ALA K 575 SHEET 1 AF1 5 ASN K 354 ILE K 358 0 SHEET 2 AF1 5 VAL K 395 ARG K 403 -1 O VAL K 395 N ILE K 358 SHEET 3 AF1 5 PRO K 507 PHE K 515 -1 O TYR K 508 N ILE K 402 SHEET 4 AF1 5 VAL K 433 ASN K 437 -1 N ILE K 434 O VAL K 511 SHEET 5 AF1 5 PHE K 374 THR K 376 -1 N THR K 376 O ALA K 435 SHEET 1 AF2 4 GLU K 654 HIS K 655 0 SHEET 2 AF2 4 ILE K 692 THR K 696 1 O ILE K 692 N GLU K 654 SHEET 3 AF2 4 ILE K 670 TYR K 674 -1 N SER K 673 O ILE K 693 SHEET 4 AF2 4 ILE K 664 GLY K 667 -1 N ILE K 666 O ILE K 670 SHEET 1 AF3 3 SER K 711 PRO K 728 0 SHEET 2 AF3 3 GLY K1059 ALA K1078 -1 O PHE K1075 N ILE K 712 SHEET 3 AF3 3 TYR K1047 ALA K1056 -1 N MET K1050 O VAL K1065 SHEET 1 AF4 5 SER K 711 PRO K 728 0 SHEET 2 AF4 5 GLY K1059 ALA K1078 -1 O PHE K1075 N ILE K 712 SHEET 3 AF4 5 VAL K1094 ASN K1098 -1 O SER K1097 N THR K1076 SHEET 4 AF4 5 HIS K1101 THR K1105 -1 O PHE K1103 N VAL K1096 SHEET 5 AF4 5 GLN K1113 ILE K1114 -1 O GLN K1113 N VAL K1104 SHEET 1 AF5 2 LYS K 733 VAL K 736 0 SHEET 2 AF5 2 LEU K 858 LEU K 861 -1 O THR K 859 N SER K 735 SHEET 1 AF6 4 THR K1120 GLY K1124 0 SHEET 2 AF6 4 LYS K1086 PRO K1090 -1 N PHE K1089 O PHE K1121 SHEET 3 AF6 4 ILE K1081 HIS K1083 -1 N HIS K1083 O LYS K1086 SHEET 4 AF6 4 VAL K1133 ASN K1134 1 O VAL K1133 N CYS K1082 SSBOND 1 CYS A 22 CYS A 96 1555 1555 2.04 SSBOND 2 CYS B 23 CYS B 88 1555 1555 2.04 SSBOND 3 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 4 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 5 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 6 CYS C 379 CYS C 432 1555 1555 2.02 SSBOND 7 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 8 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 9 CYS C 617 CYS C 649 1555 1555 2.04 SSBOND 10 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 11 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 12 CYS C 743 CYS C 749 1555 1555 2.02 SSBOND 13 CYS C 1032 CYS C 1043 1555 1555 2.02 SSBOND 14 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 15 CYS D 22 CYS D 96 1555 1555 2.04 SSBOND 16 CYS E 23 CYS E 88 1555 1555 2.04 SSBOND 17 CYS F 131 CYS F 166 1555 1555 2.03 SSBOND 18 CYS F 291 CYS F 301 1555 1555 2.03 SSBOND 19 CYS F 336 CYS F 361 1555 1555 2.03 SSBOND 20 CYS F 379 CYS F 432 1555 1555 2.02 SSBOND 21 CYS F 391 CYS F 525 1555 1555 2.03 SSBOND 22 CYS F 538 CYS F 590 1555 1555 2.03 SSBOND 23 CYS F 617 CYS F 649 1555 1555 2.03 SSBOND 24 CYS F 662 CYS F 671 1555 1555 2.03 SSBOND 25 CYS F 738 CYS F 760 1555 1555 2.03 SSBOND 26 CYS F 743 CYS F 749 1555 1555 2.02 SSBOND 27 CYS F 1032 CYS F 1043 1555 1555 2.02 SSBOND 28 CYS F 1082 CYS F 1126 1555 1555 2.03 SSBOND 29 CYS I 22 CYS I 96 1555 1555 2.04 SSBOND 30 CYS J 23 CYS J 88 1555 1555 2.03 SSBOND 31 CYS K 131 CYS K 166 1555 1555 2.03 SSBOND 32 CYS K 291 CYS K 301 1555 1555 2.03 SSBOND 33 CYS K 336 CYS K 361 1555 1555 2.03 SSBOND 34 CYS K 379 CYS K 432 1555 1555 2.02 SSBOND 35 CYS K 391 CYS K 525 1555 1555 2.03 SSBOND 36 CYS K 538 CYS K 590 1555 1555 2.03 SSBOND 37 CYS K 617 CYS K 649 1555 1555 2.03 SSBOND 38 CYS K 662 CYS K 671 1555 1555 2.03 SSBOND 39 CYS K 738 CYS K 760 1555 1555 2.03 SSBOND 40 CYS K 743 CYS K 749 1555 1555 2.02 SSBOND 41 CYS K 1032 CYS K 1043 1555 1555 2.02 SSBOND 42 CYS K 1082 CYS K 1126 1555 1555 2.03 LINK ND2 ASN C 282 C1 NAG C1301 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG C1307 1555 1555 1.44 LINK ND2 ASN C 343 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG C1303 1555 1555 1.43 LINK ND2 ASN C 709 C1 NAG C1304 1555 1555 1.43 LINK ND2 ASN C 717 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG G 1 1555 1555 1.42 LINK ND2 ASN C1074 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG C1306 1555 1555 1.45 LINK ND2 ASN C1134 C1 NAG H 1 1555 1555 1.43 LINK ND2 ASN F 282 C1 NAG F1301 1555 1555 1.44 LINK ND2 ASN F 331 C1 NAG F1307 1555 1555 1.44 LINK ND2 ASN F 343 C1 NAG F1302 1555 1555 1.44 LINK ND2 ASN F 616 C1 NAG F1303 1555 1555 1.43 LINK ND2 ASN F 709 C1 NAG F1304 1555 1555 1.43 LINK ND2 ASN F 717 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN F 801 C1 NAG L 1 1555 1555 1.42 LINK ND2 ASN F1074 C1 NAG F1305 1555 1555 1.44 LINK ND2 ASN F1098 C1 NAG F1306 1555 1555 1.45 LINK ND2 ASN F1134 C1 NAG O 1 1555 1555 1.43 LINK ND2 ASN K 282 C1 NAG K1301 1555 1555 1.44 LINK ND2 ASN K 331 C1 NAG K1307 1555 1555 1.44 LINK ND2 ASN K 343 C1 NAG K1302 1555 1555 1.44 LINK ND2 ASN K 616 C1 NAG K1303 1555 1555 1.43 LINK ND2 ASN K 709 C1 NAG K1304 1555 1555 1.43 LINK ND2 ASN K 717 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN K 801 C1 NAG Q 1 1555 1555 1.42 LINK ND2 ASN K1074 C1 NAG K1305 1555 1555 1.44 LINK ND2 ASN K1098 C1 NAG K1306 1555 1555 1.45 LINK ND2 ASN K1134 C1 NAG R 1 1555 1555 1.43 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.43 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.43 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.43 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 CISPEP 1 SER B 7 PRO B 8 0 -13.14 CISPEP 2 TYR B 94 PRO B 95 0 -3.50 CISPEP 3 SER E 7 PRO E 8 0 -13.06 CISPEP 4 TYR E 94 PRO E 95 0 -3.44 CISPEP 5 SER J 7 PRO J 8 0 -13.11 CISPEP 6 TYR J 94 PRO J 95 0 -3.54 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000