HEADER IMMUNE SYSTEM 12-SEP-24 9DMB TITLE RHESUS RHA10.01 FAB IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP TRIMER CAVEAT 9DMB COMPND MOL_ID: 1; COMPND 2 MOLECULE: RHA10.01 LIGHT CHAIN; COMPND 3 CHAIN: A, B, D; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: RHA10.01 HEAVY CHAIN; COMPND 7 CHAIN: C, G, H; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: BG505 DS-SOSIP GLYCOPROTEIN GP41; COMPND 11 CHAIN: E, I, J; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; COMPND 15 CHAIN: L, F, K; COMPND 16 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 3 ORGANISM_TAXID: 9544; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 8 ORGANISM_TAXID: 9544; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 13 ORGANISM_TAXID: 11676; SOURCE 14 GENE: ENV; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 17 MOL_ID: 4; SOURCE 18 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 19 ORGANISM_TAXID: 11676; SOURCE 20 GENE: ENV; SOURCE 21 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS CD4, HIV-1, SHIV, T681, RHESUS MACAQUE, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR J.GORMAN,P.D.KWONG REVDAT 1 18-JUN-25 9DMB 0 JRNL AUTH J.GORMAN,P.D.KWONG JRNL TITL TRANSIENT GLYCAN-SHIELD REDUCTION INDUCES CD4-BINDING SITE JRNL TITL 2 BROADLY NEUTRALIZING ANTIBODIES IN SHIV-INFECTED MACAQUES JRNL TITL 3 NEUTRALIZING ANTIBODIES IN SHIV-INFECTED RHESUS MACAQUES JRNL REF CELL REP 2025 JRNL REFN ESSN 2211-1247 REMARK 2 REMARK 2 RESOLUTION. 4.27 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : LEGINON, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.270 REMARK 3 NUMBER OF PARTICLES : 81730 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9DMB COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 13-SEP-24. REMARK 100 THE DEPOSITION ID IS D_1000288348. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : RHESUS RHA10.01 FAB IN COMPLEX REMARK 245 WITH HIV-1 ENV BG505 DS-SOSIP REMARK 245 TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 2.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 7073.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, B, G, I, D, H, J, L, REMARK 350 AND CHAINS: F, K, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i, j, k, l, REMARK 350 AND CHAINS: m, n, o, p, q, r, s, t, u, v REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ARG A 108 REMARK 465 THR A 109 REMARK 465 VAL A 110 REMARK 465 ALA A 111 REMARK 465 ALA A 112 REMARK 465 PRO A 113 REMARK 465 SER A 114 REMARK 465 VAL A 115 REMARK 465 PHE A 116 REMARK 465 ILE A 117 REMARK 465 PHE A 118 REMARK 465 PRO A 119 REMARK 465 PRO A 120 REMARK 465 SER A 121 REMARK 465 ASP A 122 REMARK 465 GLU A 123 REMARK 465 GLN A 124 REMARK 465 LEU A 125 REMARK 465 LYS A 126 REMARK 465 SER A 127 REMARK 465 GLY A 128 REMARK 465 THR A 129 REMARK 465 ALA A 130 REMARK 465 SER A 131 REMARK 465 VAL A 132 REMARK 465 VAL A 133 REMARK 465 CYS A 134 REMARK 465 LEU A 135 REMARK 465 LEU A 136 REMARK 465 ASN A 137 REMARK 465 ASN A 138 REMARK 465 PHE A 139 REMARK 465 TYR A 140 REMARK 465 PRO A 141 REMARK 465 ARG A 142 REMARK 465 GLU A 143 REMARK 465 ALA A 144 REMARK 465 LYS A 145 REMARK 465 VAL A 146 REMARK 465 GLN A 147 REMARK 465 TRP A 148 REMARK 465 LYS A 149 REMARK 465 VAL A 150 REMARK 465 ASP A 151 REMARK 465 ASN A 152 REMARK 465 ALA A 153 REMARK 465 LEU A 154 REMARK 465 GLN A 155 REMARK 465 SER A 156 REMARK 465 GLY A 157 REMARK 465 ASN A 158 REMARK 465 SER A 159 REMARK 465 GLN A 160 REMARK 465 GLU A 161 REMARK 465 SER A 162 REMARK 465 VAL A 163 REMARK 465 THR A 164 REMARK 465 GLU A 165 REMARK 465 GLN A 166 REMARK 465 ASP A 167 REMARK 465 SER A 168 REMARK 465 LYS A 169 REMARK 465 ASP A 170 REMARK 465 SER A 171 REMARK 465 THR A 172 REMARK 465 TYR A 173 REMARK 465 SER A 174 REMARK 465 LEU A 175 REMARK 465 SER A 176 REMARK 465 SER A 177 REMARK 465 THR A 178 REMARK 465 LEU A 179 REMARK 465 THR A 180 REMARK 465 LEU A 181 REMARK 465 SER A 182 REMARK 465 LYS A 183 REMARK 465 ALA A 184 REMARK 465 ASP A 185 REMARK 465 TYR A 186 REMARK 465 GLU A 187 REMARK 465 LYS A 188 REMARK 465 HIS A 189 REMARK 465 LYS A 190 REMARK 465 VAL A 191 REMARK 465 TYR A 192 REMARK 465 ALA A 193 REMARK 465 CYS A 194 REMARK 465 GLU A 195 REMARK 465 VAL A 196 REMARK 465 THR A 197 REMARK 465 HIS A 198 REMARK 465 GLN A 199 REMARK 465 GLY A 200 REMARK 465 LEU A 201 REMARK 465 SER A 202 REMARK 465 SER A 203 REMARK 465 PRO A 204 REMARK 465 VAL A 205 REMARK 465 THR A 206 REMARK 465 LYS A 207 REMARK 465 SER A 208 REMARK 465 PHE A 209 REMARK 465 ASN A 210 REMARK 465 ARG A 211 REMARK 465 GLY A 212 REMARK 465 GLU A 213 REMARK 465 CYS A 214 REMARK 465 ALA C 115 REMARK 465 SER C 116 REMARK 465 THR C 117 REMARK 465 LYS C 118 REMARK 465 GLY C 119 REMARK 465 PRO C 120 REMARK 465 SER C 121 REMARK 465 VAL C 122 REMARK 465 PHE C 123 REMARK 465 PRO C 124 REMARK 465 LEU C 125 REMARK 465 ALA C 126 REMARK 465 PRO C 127 REMARK 465 SER C 128 REMARK 465 SER C 129 REMARK 465 LYS C 130 REMARK 465 SER C 131 REMARK 465 THR C 132 REMARK 465 SER C 133 REMARK 465 GLY C 134 REMARK 465 GLY C 135 REMARK 465 THR C 136 REMARK 465 ALA C 137 REMARK 465 ALA C 138 REMARK 465 LEU C 139 REMARK 465 GLY C 140 REMARK 465 CYS C 141 REMARK 465 LEU C 142 REMARK 465 VAL C 143 REMARK 465 LYS C 144 REMARK 465 ASP C 145 REMARK 465 TYR C 146 REMARK 465 PHE C 147 REMARK 465 PRO C 148 REMARK 465 GLU C 149 REMARK 465 PRO C 150 REMARK 465 VAL C 151 REMARK 465 THR C 152 REMARK 465 VAL C 153 REMARK 465 SER C 154 REMARK 465 TRP C 155 REMARK 465 ASN C 156 REMARK 465 SER C 157 REMARK 465 GLY C 158 REMARK 465 ALA C 159 REMARK 465 LEU C 160 REMARK 465 THR C 161 REMARK 465 SER C 162 REMARK 465 GLY C 163 REMARK 465 VAL C 164 REMARK 465 HIS C 165 REMARK 465 THR C 166 REMARK 465 PHE C 167 REMARK 465 PRO C 168 REMARK 465 ALA C 169 REMARK 465 VAL C 170 REMARK 465 LEU C 171 REMARK 465 GLN C 172 REMARK 465 SER C 173 REMARK 465 SER C 174 REMARK 465 GLY C 175 REMARK 465 LEU C 176 REMARK 465 TYR C 177 REMARK 465 SER C 178 REMARK 465 LEU C 179 REMARK 465 SER C 180 REMARK 465 SER C 181 REMARK 465 VAL C 182 REMARK 465 VAL C 183 REMARK 465 THR C 184 REMARK 465 VAL C 185 REMARK 465 PRO C 186 REMARK 465 SER C 187 REMARK 465 SER C 188 REMARK 465 SER C 189 REMARK 465 LEU C 190 REMARK 465 GLY C 191 REMARK 465 THR C 192 REMARK 465 GLN C 193 REMARK 465 THR C 194 REMARK 465 TYR C 195 REMARK 465 ILE C 196 REMARK 465 CYS C 197 REMARK 465 ASN C 198 REMARK 465 VAL C 199 REMARK 465 ASN C 200 REMARK 465 HIS C 201 REMARK 465 LYS C 202 REMARK 465 PRO C 203 REMARK 465 SER C 204 REMARK 465 ASN C 205 REMARK 465 THR C 206 REMARK 465 LYS C 207 REMARK 465 VAL C 208 REMARK 465 ASP C 209 REMARK 465 LYS C 210 REMARK 465 ARG C 211 REMARK 465 VAL C 212 REMARK 465 GLU C 213 REMARK 465 PRO C 214 REMARK 465 LYS C 215 REMARK 465 SER C 216 REMARK 465 CYS C 217 REMARK 465 ASP C 218 REMARK 465 LYS C 219 REMARK 465 GLY C 220 REMARK 465 LEU C 221 REMARK 465 GLU C 222 REMARK 465 VAL C 223 REMARK 465 LEU C 224 REMARK 465 PHE C 225 REMARK 465 GLN C 226 REMARK 465 ALA E 512 REMARK 465 VAL E 513 REMARK 465 GLY E 514 REMARK 465 ILE E 515 REMARK 465 GLY E 516 REMARK 465 ALA E 517 REMARK 465 VAL E 518 REMARK 465 PHE E 519 REMARK 465 GLY E 547 REMARK 465 ILE E 548 REMARK 465 VAL E 549 REMARK 465 GLN E 550 REMARK 465 GLN E 551 REMARK 465 GLN E 552 REMARK 465 SER E 553 REMARK 465 ASN E 554 REMARK 465 LEU E 555 REMARK 465 LEU E 556 REMARK 465 ARG E 557 REMARK 465 ALA E 558 REMARK 465 PRO E 559 REMARK 465 GLU E 560 REMARK 465 ALA E 561 REMARK 465 GLN E 562 REMARK 465 GLN E 563 REMARK 465 HIS E 564 REMARK 465 LEU E 565 REMARK 465 LEU E 566 REMARK 465 LYS E 567 REMARK 465 LEU E 568 REMARK 465 ASP E 664 REMARK 465 ARG B 108 REMARK 465 THR B 109 REMARK 465 VAL B 110 REMARK 465 ALA B 111 REMARK 465 ALA B 112 REMARK 465 PRO B 113 REMARK 465 SER B 114 REMARK 465 VAL B 115 REMARK 465 PHE B 116 REMARK 465 ILE B 117 REMARK 465 PHE B 118 REMARK 465 PRO B 119 REMARK 465 PRO B 120 REMARK 465 SER B 121 REMARK 465 ASP B 122 REMARK 465 GLU B 123 REMARK 465 GLN B 124 REMARK 465 LEU B 125 REMARK 465 LYS B 126 REMARK 465 SER B 127 REMARK 465 GLY B 128 REMARK 465 THR B 129 REMARK 465 ALA B 130 REMARK 465 SER B 131 REMARK 465 VAL B 132 REMARK 465 VAL B 133 REMARK 465 CYS B 134 REMARK 465 LEU B 135 REMARK 465 LEU B 136 REMARK 465 ASN B 137 REMARK 465 ASN B 138 REMARK 465 PHE B 139 REMARK 465 TYR B 140 REMARK 465 PRO B 141 REMARK 465 ARG B 142 REMARK 465 GLU B 143 REMARK 465 ALA B 144 REMARK 465 LYS B 145 REMARK 465 VAL B 146 REMARK 465 GLN B 147 REMARK 465 TRP B 148 REMARK 465 LYS B 149 REMARK 465 VAL B 150 REMARK 465 ASP B 151 REMARK 465 ASN B 152 REMARK 465 ALA B 153 REMARK 465 LEU B 154 REMARK 465 GLN B 155 REMARK 465 SER B 156 REMARK 465 GLY B 157 REMARK 465 ASN B 158 REMARK 465 SER B 159 REMARK 465 GLN B 160 REMARK 465 GLU B 161 REMARK 465 SER B 162 REMARK 465 VAL B 163 REMARK 465 THR B 164 REMARK 465 GLU B 165 REMARK 465 GLN B 166 REMARK 465 ASP B 167 REMARK 465 SER B 168 REMARK 465 LYS B 169 REMARK 465 ASP B 170 REMARK 465 SER B 171 REMARK 465 THR B 172 REMARK 465 TYR B 173 REMARK 465 SER B 174 REMARK 465 LEU B 175 REMARK 465 SER B 176 REMARK 465 SER B 177 REMARK 465 THR B 178 REMARK 465 LEU B 179 REMARK 465 THR B 180 REMARK 465 LEU B 181 REMARK 465 SER B 182 REMARK 465 LYS B 183 REMARK 465 ALA B 184 REMARK 465 ASP B 185 REMARK 465 TYR B 186 REMARK 465 GLU B 187 REMARK 465 LYS B 188 REMARK 465 HIS B 189 REMARK 465 LYS B 190 REMARK 465 VAL B 191 REMARK 465 TYR B 192 REMARK 465 ALA B 193 REMARK 465 CYS B 194 REMARK 465 GLU B 195 REMARK 465 VAL B 196 REMARK 465 THR B 197 REMARK 465 HIS B 198 REMARK 465 GLN B 199 REMARK 465 GLY B 200 REMARK 465 LEU B 201 REMARK 465 SER B 202 REMARK 465 SER B 203 REMARK 465 PRO B 204 REMARK 465 VAL B 205 REMARK 465 THR B 206 REMARK 465 LYS B 207 REMARK 465 SER B 208 REMARK 465 PHE B 209 REMARK 465 ASN B 210 REMARK 465 ARG B 211 REMARK 465 GLY B 212 REMARK 465 GLU B 213 REMARK 465 CYS B 214 REMARK 465 ALA G 115 REMARK 465 SER G 116 REMARK 465 THR G 117 REMARK 465 LYS G 118 REMARK 465 GLY G 119 REMARK 465 PRO G 120 REMARK 465 SER G 121 REMARK 465 VAL G 122 REMARK 465 PHE G 123 REMARK 465 PRO G 124 REMARK 465 LEU G 125 REMARK 465 ALA G 126 REMARK 465 PRO G 127 REMARK 465 SER G 128 REMARK 465 SER G 129 REMARK 465 LYS G 130 REMARK 465 SER G 131 REMARK 465 THR G 132 REMARK 465 SER G 133 REMARK 465 GLY G 134 REMARK 465 GLY G 135 REMARK 465 THR G 136 REMARK 465 ALA G 137 REMARK 465 ALA G 138 REMARK 465 LEU G 139 REMARK 465 GLY G 140 REMARK 465 CYS G 141 REMARK 465 LEU G 142 REMARK 465 VAL G 143 REMARK 465 LYS G 144 REMARK 465 ASP G 145 REMARK 465 TYR G 146 REMARK 465 PHE G 147 REMARK 465 PRO G 148 REMARK 465 GLU G 149 REMARK 465 PRO G 150 REMARK 465 VAL G 151 REMARK 465 THR G 152 REMARK 465 VAL G 153 REMARK 465 SER G 154 REMARK 465 TRP G 155 REMARK 465 ASN G 156 REMARK 465 SER G 157 REMARK 465 GLY G 158 REMARK 465 ALA G 159 REMARK 465 LEU G 160 REMARK 465 THR G 161 REMARK 465 SER G 162 REMARK 465 GLY G 163 REMARK 465 VAL G 164 REMARK 465 HIS G 165 REMARK 465 THR G 166 REMARK 465 PHE G 167 REMARK 465 PRO G 168 REMARK 465 ALA G 169 REMARK 465 VAL G 170 REMARK 465 LEU G 171 REMARK 465 GLN G 172 REMARK 465 SER G 173 REMARK 465 SER G 174 REMARK 465 GLY G 175 REMARK 465 LEU G 176 REMARK 465 TYR G 177 REMARK 465 SER G 178 REMARK 465 LEU G 179 REMARK 465 SER G 180 REMARK 465 SER G 181 REMARK 465 VAL G 182 REMARK 465 VAL G 183 REMARK 465 THR G 184 REMARK 465 VAL G 185 REMARK 465 PRO G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 SER G 189 REMARK 465 LEU G 190 REMARK 465 GLY G 191 REMARK 465 THR G 192 REMARK 465 GLN G 193 REMARK 465 THR G 194 REMARK 465 TYR G 195 REMARK 465 ILE G 196 REMARK 465 CYS G 197 REMARK 465 ASN G 198 REMARK 465 VAL G 199 REMARK 465 ASN G 200 REMARK 465 HIS G 201 REMARK 465 LYS G 202 REMARK 465 PRO G 203 REMARK 465 SER G 204 REMARK 465 ASN G 205 REMARK 465 THR G 206 REMARK 465 LYS G 207 REMARK 465 VAL G 208 REMARK 465 ASP G 209 REMARK 465 LYS G 210 REMARK 465 ARG G 211 REMARK 465 VAL G 212 REMARK 465 GLU G 213 REMARK 465 PRO G 214 REMARK 465 LYS G 215 REMARK 465 SER G 216 REMARK 465 CYS G 217 REMARK 465 ASP G 218 REMARK 465 LYS G 219 REMARK 465 GLY G 220 REMARK 465 LEU G 221 REMARK 465 GLU G 222 REMARK 465 VAL G 223 REMARK 465 LEU G 224 REMARK 465 PHE G 225 REMARK 465 GLN G 226 REMARK 465 ALA I 512 REMARK 465 VAL I 513 REMARK 465 GLY I 514 REMARK 465 ILE I 515 REMARK 465 GLY I 516 REMARK 465 ALA I 517 REMARK 465 VAL I 518 REMARK 465 PHE I 519 REMARK 465 GLY I 547 REMARK 465 ILE I 548 REMARK 465 VAL I 549 REMARK 465 GLN I 550 REMARK 465 GLN I 551 REMARK 465 GLN I 552 REMARK 465 SER I 553 REMARK 465 ASN I 554 REMARK 465 LEU I 555 REMARK 465 LEU I 556 REMARK 465 ARG I 557 REMARK 465 ALA I 558 REMARK 465 PRO I 559 REMARK 465 GLU I 560 REMARK 465 ALA I 561 REMARK 465 GLN I 562 REMARK 465 GLN I 563 REMARK 465 HIS I 564 REMARK 465 LEU I 565 REMARK 465 LEU I 566 REMARK 465 LYS I 567 REMARK 465 LEU I 568 REMARK 465 ASP I 664 REMARK 465 ARG D 108 REMARK 465 THR D 109 REMARK 465 VAL D 110 REMARK 465 ALA D 111 REMARK 465 ALA D 112 REMARK 465 PRO D 113 REMARK 465 SER D 114 REMARK 465 VAL D 115 REMARK 465 PHE D 116 REMARK 465 ILE D 117 REMARK 465 PHE D 118 REMARK 465 PRO D 119 REMARK 465 PRO D 120 REMARK 465 SER D 121 REMARK 465 ASP D 122 REMARK 465 GLU D 123 REMARK 465 GLN D 124 REMARK 465 LEU D 125 REMARK 465 LYS D 126 REMARK 465 SER D 127 REMARK 465 GLY D 128 REMARK 465 THR D 129 REMARK 465 ALA D 130 REMARK 465 SER D 131 REMARK 465 VAL D 132 REMARK 465 VAL D 133 REMARK 465 CYS D 134 REMARK 465 LEU D 135 REMARK 465 LEU D 136 REMARK 465 ASN D 137 REMARK 465 ASN D 138 REMARK 465 PHE D 139 REMARK 465 TYR D 140 REMARK 465 PRO D 141 REMARK 465 ARG D 142 REMARK 465 GLU D 143 REMARK 465 ALA D 144 REMARK 465 LYS D 145 REMARK 465 VAL D 146 REMARK 465 GLN D 147 REMARK 465 TRP D 148 REMARK 465 LYS D 149 REMARK 465 VAL D 150 REMARK 465 ASP D 151 REMARK 465 ASN D 152 REMARK 465 ALA D 153 REMARK 465 LEU D 154 REMARK 465 GLN D 155 REMARK 465 SER D 156 REMARK 465 GLY D 157 REMARK 465 ASN D 158 REMARK 465 SER D 159 REMARK 465 GLN D 160 REMARK 465 GLU D 161 REMARK 465 SER D 162 REMARK 465 VAL D 163 REMARK 465 THR D 164 REMARK 465 GLU D 165 REMARK 465 GLN D 166 REMARK 465 ASP D 167 REMARK 465 SER D 168 REMARK 465 LYS D 169 REMARK 465 ASP D 170 REMARK 465 SER D 171 REMARK 465 THR D 172 REMARK 465 TYR D 173 REMARK 465 SER D 174 REMARK 465 LEU D 175 REMARK 465 SER D 176 REMARK 465 SER D 177 REMARK 465 THR D 178 REMARK 465 LEU D 179 REMARK 465 THR D 180 REMARK 465 LEU D 181 REMARK 465 SER D 182 REMARK 465 LYS D 183 REMARK 465 ALA D 184 REMARK 465 ASP D 185 REMARK 465 TYR D 186 REMARK 465 GLU D 187 REMARK 465 LYS D 188 REMARK 465 HIS D 189 REMARK 465 LYS D 190 REMARK 465 VAL D 191 REMARK 465 TYR D 192 REMARK 465 ALA D 193 REMARK 465 CYS D 194 REMARK 465 GLU D 195 REMARK 465 VAL D 196 REMARK 465 THR D 197 REMARK 465 HIS D 198 REMARK 465 GLN D 199 REMARK 465 GLY D 200 REMARK 465 LEU D 201 REMARK 465 SER D 202 REMARK 465 SER D 203 REMARK 465 PRO D 204 REMARK 465 VAL D 205 REMARK 465 THR D 206 REMARK 465 LYS D 207 REMARK 465 SER D 208 REMARK 465 PHE D 209 REMARK 465 ASN D 210 REMARK 465 ARG D 211 REMARK 465 GLY D 212 REMARK 465 GLU D 213 REMARK 465 CYS D 214 REMARK 465 ALA H 115 REMARK 465 SER H 116 REMARK 465 THR H 117 REMARK 465 LYS H 118 REMARK 465 GLY H 119 REMARK 465 PRO H 120 REMARK 465 SER H 121 REMARK 465 VAL H 122 REMARK 465 PHE H 123 REMARK 465 PRO H 124 REMARK 465 LEU H 125 REMARK 465 ALA H 126 REMARK 465 PRO H 127 REMARK 465 SER H 128 REMARK 465 SER H 129 REMARK 465 LYS H 130 REMARK 465 SER H 131 REMARK 465 THR H 132 REMARK 465 SER H 133 REMARK 465 GLY H 134 REMARK 465 GLY H 135 REMARK 465 THR H 136 REMARK 465 ALA H 137 REMARK 465 ALA H 138 REMARK 465 LEU H 139 REMARK 465 GLY H 140 REMARK 465 CYS H 141 REMARK 465 LEU H 142 REMARK 465 VAL H 143 REMARK 465 LYS H 144 REMARK 465 ASP H 145 REMARK 465 TYR H 146 REMARK 465 PHE H 147 REMARK 465 PRO H 148 REMARK 465 GLU H 149 REMARK 465 PRO H 150 REMARK 465 VAL H 151 REMARK 465 THR H 152 REMARK 465 VAL H 153 REMARK 465 SER H 154 REMARK 465 TRP H 155 REMARK 465 ASN H 156 REMARK 465 SER H 157 REMARK 465 GLY H 158 REMARK 465 ALA H 159 REMARK 465 LEU H 160 REMARK 465 THR H 161 REMARK 465 SER H 162 REMARK 465 GLY H 163 REMARK 465 VAL H 164 REMARK 465 HIS H 165 REMARK 465 THR H 166 REMARK 465 PHE H 167 REMARK 465 PRO H 168 REMARK 465 ALA H 169 REMARK 465 VAL H 170 REMARK 465 LEU H 171 REMARK 465 GLN H 172 REMARK 465 SER H 173 REMARK 465 SER H 174 REMARK 465 GLY H 175 REMARK 465 LEU H 176 REMARK 465 TYR H 177 REMARK 465 SER H 178 REMARK 465 LEU H 179 REMARK 465 SER H 180 REMARK 465 SER H 181 REMARK 465 VAL H 182 REMARK 465 VAL H 183 REMARK 465 THR H 184 REMARK 465 VAL H 185 REMARK 465 PRO H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 SER H 189 REMARK 465 LEU H 190 REMARK 465 GLY H 191 REMARK 465 THR H 192 REMARK 465 GLN H 193 REMARK 465 THR H 194 REMARK 465 TYR H 195 REMARK 465 ILE H 196 REMARK 465 CYS H 197 REMARK 465 ASN H 198 REMARK 465 VAL H 199 REMARK 465 ASN H 200 REMARK 465 HIS H 201 REMARK 465 LYS H 202 REMARK 465 PRO H 203 REMARK 465 SER H 204 REMARK 465 ASN H 205 REMARK 465 THR H 206 REMARK 465 LYS H 207 REMARK 465 VAL H 208 REMARK 465 ASP H 209 REMARK 465 LYS H 210 REMARK 465 ARG H 211 REMARK 465 VAL H 212 REMARK 465 GLU H 213 REMARK 465 PRO H 214 REMARK 465 LYS H 215 REMARK 465 SER H 216 REMARK 465 CYS H 217 REMARK 465 ASP H 218 REMARK 465 LYS H 219 REMARK 465 GLY H 220 REMARK 465 LEU H 221 REMARK 465 GLU H 222 REMARK 465 VAL H 223 REMARK 465 LEU H 224 REMARK 465 PHE H 225 REMARK 465 GLN H 226 REMARK 465 ALA J 512 REMARK 465 VAL J 513 REMARK 465 GLY J 514 REMARK 465 ILE J 515 REMARK 465 GLY J 516 REMARK 465 ALA J 517 REMARK 465 VAL J 518 REMARK 465 PHE J 519 REMARK 465 GLY J 547 REMARK 465 ILE J 548 REMARK 465 VAL J 549 REMARK 465 GLN J 550 REMARK 465 GLN J 551 REMARK 465 GLN J 552 REMARK 465 SER J 553 REMARK 465 ASN J 554 REMARK 465 LEU J 555 REMARK 465 LEU J 556 REMARK 465 ARG J 557 REMARK 465 ALA J 558 REMARK 465 PRO J 559 REMARK 465 GLU J 560 REMARK 465 ALA J 561 REMARK 465 GLN J 562 REMARK 465 GLN J 563 REMARK 465 HIS J 564 REMARK 465 LEU J 565 REMARK 465 LEU J 566 REMARK 465 LYS J 567 REMARK 465 LEU J 568 REMARK 465 ASP J 664 REMARK 465 ALA L 31 REMARK 465 GLU L 185A REMARK 465 ASN L 185B REMARK 465 GLN L 185C REMARK 465 GLY L 185D REMARK 465 ASN L 185E REMARK 465 ARG L 185F REMARK 465 SER L 185G REMARK 465 ASN L 185H REMARK 465 ASN L 185I REMARK 465 SER L 185J REMARK 465 THR L 400 REMARK 465 SER L 401 REMARK 465 VAL L 402 REMARK 465 GLN L 403 REMARK 465 GLY L 404 REMARK 465 SER L 405 REMARK 465 ASN L 406 REMARK 465 SER L 407 REMARK 465 THR L 408 REMARK 465 GLY L 409 REMARK 465 SER L 410 REMARK 465 VAL L 506 REMARK 465 GLY L 507 REMARK 465 ARG L 508 REMARK 465 ARG L 509 REMARK 465 ARG L 510 REMARK 465 ARG L 511 REMARK 465 ARG L 512 REMARK 465 ALA F 31 REMARK 465 GLU F 185A REMARK 465 ASN F 185B REMARK 465 GLN F 185C REMARK 465 GLY F 185D REMARK 465 ASN F 185E REMARK 465 ARG F 185F REMARK 465 SER F 185G REMARK 465 ASN F 185H REMARK 465 ASN F 185I REMARK 465 SER F 185J REMARK 465 THR F 400 REMARK 465 SER F 401 REMARK 465 VAL F 402 REMARK 465 GLN F 403 REMARK 465 GLY F 404 REMARK 465 SER F 405 REMARK 465 ASN F 406 REMARK 465 SER F 407 REMARK 465 THR F 408 REMARK 465 GLY F 409 REMARK 465 SER F 410 REMARK 465 VAL F 506 REMARK 465 GLY F 507 REMARK 465 ARG F 508 REMARK 465 ARG F 509 REMARK 465 ARG F 510 REMARK 465 ARG F 511 REMARK 465 ARG F 512 REMARK 465 ALA K 31 REMARK 465 GLU K 185A REMARK 465 ASN K 185B REMARK 465 GLN K 185C REMARK 465 GLY K 185D REMARK 465 ASN K 185E REMARK 465 ARG K 185F REMARK 465 SER K 185G REMARK 465 ASN K 185H REMARK 465 ASN K 185I REMARK 465 SER K 185J REMARK 465 THR K 400 REMARK 465 SER K 401 REMARK 465 VAL K 402 REMARK 465 GLN K 403 REMARK 465 GLY K 404 REMARK 465 SER K 405 REMARK 465 ASN K 406 REMARK 465 SER K 407 REMARK 465 THR K 408 REMARK 465 GLY K 409 REMARK 465 SER K 410 REMARK 465 VAL K 506 REMARK 465 GLY K 507 REMARK 465 ARG K 508 REMARK 465 ARG K 509 REMARK 465 ARG K 510 REMARK 465 ARG K 511 REMARK 465 ARG K 512 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OD2 ASP L 457 OG1 THR L 467 2.14 REMARK 500 OD2 ASP F 457 OG1 THR F 467 2.15 REMARK 500 OD2 ASP K 457 OG1 THR K 467 2.15 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ARG A 50 -104.96 45.50 REMARK 500 PRO A 59 69.78 -63.49 REMARK 500 THR A 69 -70.97 63.10 REMARK 500 THR A 92 -71.11 -56.25 REMARK 500 GLN A 93 -66.07 -123.13 REMARK 500 SER C 31 -158.32 -78.26 REMARK 500 ILE C 48 -60.52 -107.19 REMARK 500 ALA C 101M 174.26 178.58 REMARK 500 ASP C 102 -168.67 -79.31 REMARK 500 CYS E 598 148.15 -173.72 REMARK 500 LEU E 602 12.09 51.61 REMARK 500 ARG B 50 -105.15 45.18 REMARK 500 PRO B 59 69.50 -63.63 REMARK 500 THR B 69 -70.84 62.97 REMARK 500 THR B 92 -71.06 -56.19 REMARK 500 GLN B 93 -66.04 -123.10 REMARK 500 SER G 31 -158.40 -78.62 REMARK 500 ILE G 48 -60.38 -107.13 REMARK 500 ALA G 101M 174.23 178.54 REMARK 500 ASP G 102 -168.52 -79.04 REMARK 500 CYS I 598 148.05 -173.13 REMARK 500 LEU I 602 12.06 51.65 REMARK 500 ARG D 50 -104.97 45.41 REMARK 500 PRO D 59 69.61 -63.59 REMARK 500 THR D 69 -71.02 63.10 REMARK 500 THR D 92 -71.01 -56.31 REMARK 500 GLN D 93 -66.19 -123.10 REMARK 500 SER H 31 -158.39 -78.24 REMARK 500 ILE H 48 -60.40 -107.07 REMARK 500 ALA H 101M 174.27 178.54 REMARK 500 ASP H 102 -168.81 -79.29 REMARK 500 CYS J 598 148.26 -173.84 REMARK 500 LEU J 602 12.06 51.61 REMARK 500 ASN L 80 70.55 53.96 REMARK 500 ASN L 137 51.76 37.51 REMARK 500 ASN L 234 30.95 -99.38 REMARK 500 SER L 256 148.36 -171.51 REMARK 500 ILE L 277 -63.94 61.98 REMARK 500 SER L 364 -175.97 62.26 REMARK 500 ASN L 392 11.63 -140.15 REMARK 500 CYS L 418 -170.00 -163.15 REMARK 500 TRP L 427 71.84 57.03 REMARK 500 ILE L 430 -36.21 -38.18 REMARK 500 THR L 461 -168.90 -168.19 REMARK 500 ASN F 80 70.52 53.85 REMARK 500 ASN F 137 51.76 37.57 REMARK 500 ASN F 234 30.97 -98.55 REMARK 500 SER F 256 148.42 -171.45 REMARK 500 ILE F 277 -63.95 62.02 REMARK 500 SER F 364 -175.95 62.18 REMARK 500 REMARK 500 THIS ENTRY HAS 64 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 TRP L 427 GLN L 428 -149.30 REMARK 500 TRP F 427 GLN F 428 -149.23 REMARK 500 TRP K 427 GLN K 428 -149.26 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-47000 RELATED DB: EMDB REMARK 900 RHESUS RHA10.01 FAB IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP TRIMER DBREF 9DMB A 1 214 PDB 9DMB 9DMB 1 214 DBREF 9DMB C 1 226 PDB 9DMB 9DMB 1 226 DBREF 9DMB E 512 664 UNP Q2N0S5 Q2N0S5_9HIV1 509 661 DBREF 9DMB B 1 214 PDB 9DMB 9DMB 1 214 DBREF 9DMB G 1 226 PDB 9DMB 9DMB 1 226 DBREF 9DMB I 512 664 UNP Q2N0S5 Q2N0S5_9HIV1 509 661 DBREF 9DMB D 1 214 PDB 9DMB 9DMB 1 214 DBREF 9DMB H 1 226 PDB 9DMB 9DMB 1 226 DBREF 9DMB J 512 664 UNP Q2N0S5 Q2N0S5_9HIV1 509 661 DBREF 9DMB L 31 512 UNP Q2N0S6 Q2N0S6_9HIV1 30 509 DBREF 9DMB F 31 512 UNP Q2N0S6 Q2N0S6_9HIV1 30 509 DBREF 9DMB K 31 512 UNP Q2N0S6 Q2N0S6_9HIV1 30 509 SEQADV 9DMB PRO E 559 UNP Q2N0S5 ILE 556 ENGINEERED MUTATION SEQADV 9DMB CYS E 605 UNP Q2N0S5 THR 602 ENGINEERED MUTATION SEQADV 9DMB PRO I 559 UNP Q2N0S5 ILE 556 ENGINEERED MUTATION SEQADV 9DMB CYS I 605 UNP Q2N0S5 THR 602 ENGINEERED MUTATION SEQADV 9DMB PRO J 559 UNP Q2N0S5 ILE 556 ENGINEERED MUTATION SEQADV 9DMB CYS J 605 UNP Q2N0S5 THR 602 ENGINEERED MUTATION SEQADV 9DMB CYS L 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 9DMB ASN L 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 9DMB CYS L 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 9DMB CYS L 501 UNP Q2N0S6 ALA 498 CONFLICT SEQADV 9DMB ARG L 509 UNP Q2N0S6 GLU 506 CONFLICT SEQADV 9DMB ARG L 510 UNP Q2N0S6 LYS 507 CONFLICT SEQADV 9DMB ARG L 512 UNP Q2N0S6 ALA 509 CONFLICT SEQADV 9DMB CYS F 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 9DMB ASN F 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 9DMB CYS F 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 9DMB CYS F 501 UNP Q2N0S6 ALA 498 CONFLICT SEQADV 9DMB ARG F 509 UNP Q2N0S6 GLU 506 CONFLICT SEQADV 9DMB ARG F 510 UNP Q2N0S6 LYS 507 CONFLICT SEQADV 9DMB ARG F 512 UNP Q2N0S6 ALA 509 CONFLICT SEQADV 9DMB CYS K 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 9DMB ASN K 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 9DMB CYS K 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 9DMB CYS K 501 UNP Q2N0S6 ALA 498 CONFLICT SEQADV 9DMB ARG K 509 UNP Q2N0S6 GLU 506 CONFLICT SEQADV 9DMB ARG K 510 UNP Q2N0S6 LYS 507 CONFLICT SEQADV 9DMB ARG K 512 UNP Q2N0S6 ALA 509 CONFLICT SEQRES 1 A 219 ASP ILE VAL MET THR GLN ILE PRO VAL SER LEU SER VAL SEQRES 2 A 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS SER SER SER SEQRES 3 A 219 GLN SER LEU GLN HIS ILE SER GLY TYR THR TYR LEU ASP SEQRES 4 A 219 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 A 219 ILE SER ARG VAL SER GLY ARG ALA SER GLY VAL PRO ASP SEQRES 6 A 219 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE MET LEU SEQRES 7 A 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY ILE TYR SEQRES 8 A 219 TYR CYS MET GLN GLY THR GLN LEU PRO PHE SER PHE GLY SEQRES 9 A 219 GLN GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 A 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 A 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 A 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 A 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 A 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 A 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 A 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 A 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 C 243 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU LEU LYS SEQRES 2 C 243 PRO SER GLU THR LEU SER LEU THR CYS ALA VAL SER GLY SEQRES 3 C 243 VAL SER ILE THR SER TYR PRO TRP SER TRP ILE ARG GLN SEQRES 4 C 243 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY ARG ILE PHE SEQRES 5 C 243 THR VAL GLY GLY HIS THR ASP LEU ASN PRO SER LEU LYS SEQRES 6 C 243 SER ARG VAL THR ILE ALA ARG ASP SER SER ARG ASN GLN SEQRES 7 C 243 VAL SER LEU ILE LEU ARG SER VAL THR ALA ALA ASP THR SEQRES 8 C 243 ALA LEU TYR TYR CYS ALA ARG VAL PRO PHE TYR TRP ASN SEQRES 9 C 243 ASN LYS SER TRP TYR GLY GLY ALA TYR GLN TRP TYR ALA SEQRES 10 C 243 LEU ASP SER TRP GLY GLN GLY VAL ALA VAL THR VAL SER SEQRES 11 C 243 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 12 C 243 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 13 C 243 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 C 243 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 C 243 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 C 243 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 C 243 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 C 243 ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 19 C 243 ASP LYS GLY LEU GLU VAL LEU PHE GLN SEQRES 1 E 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 E 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 E 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 E 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 E 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 E 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 E 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 E 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 E 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 E 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 E 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 E 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 B 219 ASP ILE VAL MET THR GLN ILE PRO VAL SER LEU SER VAL SEQRES 2 B 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS SER SER SER SEQRES 3 B 219 GLN SER LEU GLN HIS ILE SER GLY TYR THR TYR LEU ASP SEQRES 4 B 219 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 B 219 ILE SER ARG VAL SER GLY ARG ALA SER GLY VAL PRO ASP SEQRES 6 B 219 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE MET LEU SEQRES 7 B 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY ILE TYR SEQRES 8 B 219 TYR CYS MET GLN GLY THR GLN LEU PRO PHE SER PHE GLY SEQRES 9 B 219 GLN GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 B 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 B 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 B 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 B 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 B 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 B 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 B 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 B 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 G 243 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU LEU LYS SEQRES 2 G 243 PRO SER GLU THR LEU SER LEU THR CYS ALA VAL SER GLY SEQRES 3 G 243 VAL SER ILE THR SER TYR PRO TRP SER TRP ILE ARG GLN SEQRES 4 G 243 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY ARG ILE PHE SEQRES 5 G 243 THR VAL GLY GLY HIS THR ASP LEU ASN PRO SER LEU LYS SEQRES 6 G 243 SER ARG VAL THR ILE ALA ARG ASP SER SER ARG ASN GLN SEQRES 7 G 243 VAL SER LEU ILE LEU ARG SER VAL THR ALA ALA ASP THR SEQRES 8 G 243 ALA LEU TYR TYR CYS ALA ARG VAL PRO PHE TYR TRP ASN SEQRES 9 G 243 ASN LYS SER TRP TYR GLY GLY ALA TYR GLN TRP TYR ALA SEQRES 10 G 243 LEU ASP SER TRP GLY GLN GLY VAL ALA VAL THR VAL SER SEQRES 11 G 243 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 12 G 243 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 13 G 243 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 G 243 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 G 243 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 G 243 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 G 243 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 G 243 ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 19 G 243 ASP LYS GLY LEU GLU VAL LEU PHE GLN SEQRES 1 I 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 I 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 I 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 I 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 I 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 I 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 I 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 I 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 I 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 I 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 I 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 I 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 D 219 ASP ILE VAL MET THR GLN ILE PRO VAL SER LEU SER VAL SEQRES 2 D 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS SER SER SER SEQRES 3 D 219 GLN SER LEU GLN HIS ILE SER GLY TYR THR TYR LEU ASP SEQRES 4 D 219 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 D 219 ILE SER ARG VAL SER GLY ARG ALA SER GLY VAL PRO ASP SEQRES 6 D 219 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE MET LEU SEQRES 7 D 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY ILE TYR SEQRES 8 D 219 TYR CYS MET GLN GLY THR GLN LEU PRO PHE SER PHE GLY SEQRES 9 D 219 GLN GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 D 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 D 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 D 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 D 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 D 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 D 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 D 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 D 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 H 243 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU LEU LYS SEQRES 2 H 243 PRO SER GLU THR LEU SER LEU THR CYS ALA VAL SER GLY SEQRES 3 H 243 VAL SER ILE THR SER TYR PRO TRP SER TRP ILE ARG GLN SEQRES 4 H 243 SER PRO GLY LYS GLY LEU GLU TRP ILE GLY ARG ILE PHE SEQRES 5 H 243 THR VAL GLY GLY HIS THR ASP LEU ASN PRO SER LEU LYS SEQRES 6 H 243 SER ARG VAL THR ILE ALA ARG ASP SER SER ARG ASN GLN SEQRES 7 H 243 VAL SER LEU ILE LEU ARG SER VAL THR ALA ALA ASP THR SEQRES 8 H 243 ALA LEU TYR TYR CYS ALA ARG VAL PRO PHE TYR TRP ASN SEQRES 9 H 243 ASN LYS SER TRP TYR GLY GLY ALA TYR GLN TRP TYR ALA SEQRES 10 H 243 LEU ASP SER TRP GLY GLN GLY VAL ALA VAL THR VAL SER SEQRES 11 H 243 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 12 H 243 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 13 H 243 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 H 243 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 H 243 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 H 243 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 H 243 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 H 243 ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 19 H 243 ASP LYS GLY LEU GLU VAL LEU PHE GLN SEQRES 1 J 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 J 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 J 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 J 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 J 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 J 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 J 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 J 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 J 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 J 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 J 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 J 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 L 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 L 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 L 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 L 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 L 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 L 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 L 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 L 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 L 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 L 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 L 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 L 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 L 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 L 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 L 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 L 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 L 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 L 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 L 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 L 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 L 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 L 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 L 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 L 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 L 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 L 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 L 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 L 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 L 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 L 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 L 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 L 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 L 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 L 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 L 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 L 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 L 480 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 1 F 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 F 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 F 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 F 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 F 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 F 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 F 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 F 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 F 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 F 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 F 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 F 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 F 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 F 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 F 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 F 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 F 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 F 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 F 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 F 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 F 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 F 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 F 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 F 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 F 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 F 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 F 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 F 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 F 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 F 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 F 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 F 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 F 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 F 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 F 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 F 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 F 480 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 1 K 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 K 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 K 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 K 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 K 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 K 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 K 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 K 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 K 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 K 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 K 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 K 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 K 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 K 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 K 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 K 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 K 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 K 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 K 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 K 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 K 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 K 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 K 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 K 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 K 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 K 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 K 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 K 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 K 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 K 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 K 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 K 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 K 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 K 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 K 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 K 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 K 480 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET BMA N 3 11 HET MAN N 4 11 HET MAN N 5 11 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET NAG Q 1 14 HET NAG Q 2 14 HET BMA Q 3 11 HET MAN Q 4 11 HET MAN Q 5 11 HET NAG R 1 14 HET NAG R 2 14 HET BMA R 3 11 HET NAG S 1 14 HET NAG S 2 14 HET BMA S 3 11 HET MAN S 4 11 HET MAN S 5 11 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET BMA V 3 11 HET NAG W 1 14 HET NAG W 2 14 HET BMA W 3 11 HET NAG X 1 14 HET NAG X 2 14 HET NAG Y 1 14 HET NAG Y 2 14 HET NAG Z 1 14 HET NAG Z 2 14 HET BMA Z 3 11 HET MAN Z 4 11 HET MAN Z 5 11 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET BMA b 3 11 HET NAG c 1 14 HET NAG c 2 14 HET BMA c 3 11 HET MAN c 4 11 HET MAN c 5 11 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET NAG e 1 14 HET NAG e 2 14 HET BMA e 3 11 HET MAN e 4 11 HET MAN e 5 11 HET NAG f 1 14 HET NAG f 2 14 HET BMA f 3 11 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET BMA h 3 11 HET NAG i 1 14 HET NAG i 2 14 HET BMA i 3 11 HET NAG j 1 14 HET NAG j 2 14 HET NAG k 1 14 HET NAG k 2 14 HET NAG l 1 14 HET NAG l 2 14 HET BMA l 3 11 HET MAN l 4 11 HET MAN l 5 11 HET NAG m 1 14 HET NAG m 2 14 HET NAG n 1 14 HET NAG n 2 14 HET BMA n 3 11 HET NAG o 1 14 HET NAG o 2 14 HET BMA o 3 11 HET MAN o 4 11 HET MAN o 5 11 HET NAG p 1 14 HET NAG p 2 14 HET BMA p 3 11 HET NAG q 1 14 HET NAG q 2 14 HET BMA q 3 11 HET MAN q 4 11 HET MAN q 5 11 HET NAG r 1 14 HET NAG r 2 14 HET BMA r 3 11 HET NAG s 1 14 HET NAG s 2 14 HET NAG t 1 14 HET NAG t 2 14 HET BMA t 3 11 HET NAG u 1 14 HET NAG u 2 14 HET BMA u 3 11 HET NAG v 1 14 HET NAG v 2 14 HET NAG E 701 14 HET NAG E 702 14 HET NAG I 701 14 HET NAG I 702 14 HET NAG J 701 14 HET NAG J 702 14 HET NAG L 601 14 HET NAG L 602 14 HET NAG L 603 14 HET NAG L 604 14 HET NAG L 605 14 HET NAG L 606 14 HET NAG L 607 14 HET NAG F 601 14 HET NAG F 602 14 HET NAG F 603 14 HET NAG F 604 14 HET NAG F 605 14 HET NAG F 606 14 HET NAG F 607 14 HET NAG K 601 14 HET NAG K 602 14 HET NAG K 603 14 HET NAG K 604 14 HET NAG K 605 14 HET NAG K 606 14 HET NAG K 607 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 13 NAG 99(C8 H15 N O6) FORMUL 14 BMA 24(C6 H12 O6) FORMUL 14 MAN 18(C6 H12 O6) HELIX 1 AA1 THR C 84 THR C 88 5 5 HELIX 2 AA2 THR E 529 SER E 534 1 6 HELIX 3 AA3 LEU E 537 ASN E 543 1 7 HELIX 4 AA4 VAL E 570 ILE E 595 1 26 HELIX 5 AA5 ASN E 611 ASN E 616 1 6 HELIX 6 AA6 THR E 627 ILE E 635 1 9 HELIX 7 AA7 ILE E 641 LEU E 663 1 23 HELIX 8 AA8 THR G 84 THR G 88 5 5 HELIX 9 AA9 THR I 529 SER I 534 1 6 HELIX 10 AB1 LEU I 537 ASN I 543 1 7 HELIX 11 AB2 VAL I 570 ILE I 595 1 26 HELIX 12 AB3 ASN I 611 ASN I 616 1 6 HELIX 13 AB4 THR I 627 ILE I 635 1 9 HELIX 14 AB5 ILE I 641 LEU I 663 1 23 HELIX 15 AB6 THR H 84 THR H 88 5 5 HELIX 16 AB7 THR J 529 SER J 534 1 6 HELIX 17 AB8 LEU J 537 ASN J 543 1 7 HELIX 18 AB9 VAL J 570 ILE J 595 1 26 HELIX 19 AC1 ASN J 611 ASN J 616 1 6 HELIX 20 AC2 THR J 627 ILE J 635 1 9 HELIX 21 AC3 ILE J 641 LEU J 663 1 23 HELIX 22 AC4 ASP L 57 THR L 63 1 7 HELIX 23 AC5 ASN L 98 LEU L 116 1 19 HELIX 24 AC6 LEU L 122 CYS L 126 5 5 HELIX 25 AC7 THR L 139 GLY L 152 5 6 HELIX 26 AC8 LYS L 335 GLY L 354 1 20 HELIX 27 AC9 ASP L 474 SER L 481 1 8 HELIX 28 AD1 ASP F 57 THR F 63 1 7 HELIX 29 AD2 ASN F 98 LEU F 116 1 19 HELIX 30 AD3 LEU F 122 CYS F 126 5 5 HELIX 31 AD4 THR F 139 GLY F 152 5 6 HELIX 32 AD5 LYS F 335 GLY F 354 1 20 HELIX 33 AD6 ASP F 474 SER F 481 1 8 HELIX 34 AD7 ASP K 57 THR K 63 1 7 HELIX 35 AD8 ASN K 98 LEU K 116 1 19 HELIX 36 AD9 LEU K 122 CYS K 126 5 5 HELIX 37 AE1 THR K 139 GLY K 152 5 6 HELIX 38 AE2 LYS K 335 GLY K 354 1 20 HELIX 39 AE3 ASP K 474 SER K 481 1 8 SHEET 1 AA1 4 THR A 5 ILE A 7 0 SHEET 2 AA1 4 SER A 20 SER A 24 -1 O SER A 22 N ILE A 7 SHEET 3 AA1 4 ASP A 70 ILE A 75 -1 O PHE A 71 N CYS A 23 SHEET 4 AA1 4 PHE A 62 SER A 63 -1 N SER A 63 O LYS A 74 SHEET 1 AA2 5 SER A 10 VAL A 13 0 SHEET 2 AA2 5 THR A 102 ILE A 106 1 O GLU A 105 N LEU A 11 SHEET 3 AA2 5 ILE A 85 GLN A 90 -1 N TYR A 86 O THR A 102 SHEET 4 AA2 5 LEU A 33 GLN A 38 -1 N GLN A 38 O ILE A 85 SHEET 5 AA2 5 GLN A 45 ILE A 48 -1 O LEU A 47 N TRP A 35 SHEET 1 AA3 4 GLN C 5 SER C 7 0 SHEET 2 AA3 4 LEU C 18 ALA C 23 -1 O ALA C 23 N GLN C 5 SHEET 3 AA3 4 GLN C 78 LEU C 83 -1 O LEU C 83 N LEU C 18 SHEET 4 AA3 4 THR C 69 ASP C 73 -1 N THR C 69 O ILE C 82 SHEET 1 AA4 2 LEU C 11 LEU C 12 0 SHEET 2 AA4 2 THR C 111 VAL C 112 1 O THR C 111 N LEU C 12 SHEET 1 AA5 3 GLU C 46 ARG C 50 0 SHEET 2 AA5 3 TRP C 34 ARG C 38 -1 N TRP C 36 O GLY C 49 SHEET 3 AA5 3 TYR C 91 ARG C 95 -1 O TYR C 92 N ILE C 37 SHEET 1 AA6 2 TYR C 99 TRP C 100 0 SHEET 2 AA6 2 GLN C 101J TRP C 101K-1 O GLN C 101J N TRP C 100 SHEET 1 AA7 3 ILE E 603 CYS E 604 0 SHEET 2 AA7 3 TRP K 35 TYR K 39 -1 O VAL K 38 N CYS E 604 SHEET 3 AA7 3 GLY K 495 THR K 499 -1 O THR K 499 N TRP K 35 SHEET 1 AA8 4 THR B 5 ILE B 7 0 SHEET 2 AA8 4 SER B 20 SER B 24 -1 O SER B 22 N ILE B 7 SHEET 3 AA8 4 ASP B 70 ILE B 75 -1 O PHE B 71 N CYS B 23 SHEET 4 AA8 4 PHE B 62 SER B 63 -1 N SER B 63 O LYS B 74 SHEET 1 AA9 5 SER B 10 VAL B 13 0 SHEET 2 AA9 5 THR B 102 ILE B 106 1 O GLU B 105 N LEU B 11 SHEET 3 AA9 5 ILE B 85 GLN B 90 -1 N TYR B 86 O THR B 102 SHEET 4 AA9 5 LEU B 33 GLN B 38 -1 N GLN B 38 O ILE B 85 SHEET 5 AA9 5 GLN B 45 ILE B 48 -1 O LEU B 47 N TRP B 35 SHEET 1 AB1 4 GLN G 5 SER G 7 0 SHEET 2 AB1 4 LEU G 18 ALA G 23 -1 O ALA G 23 N GLN G 5 SHEET 3 AB1 4 GLN G 78 LEU G 83 -1 O LEU G 83 N LEU G 18 SHEET 4 AB1 4 THR G 69 ASP G 73 -1 N THR G 69 O ILE G 82 SHEET 1 AB2 2 LEU G 11 LEU G 12 0 SHEET 2 AB2 2 THR G 111 VAL G 112 1 O THR G 111 N LEU G 12 SHEET 1 AB3 3 GLU G 46 ARG G 50 0 SHEET 2 AB3 3 TRP G 34 ARG G 38 -1 N TRP G 36 O GLY G 49 SHEET 3 AB3 3 TYR G 91 ARG G 95 -1 O TYR G 92 N ILE G 37 SHEET 1 AB4 2 TYR G 99 TRP G 100 0 SHEET 2 AB4 2 GLN G 101J TRP G 101K-1 O GLN G 101J N TRP G 100 SHEET 1 AB5 3 ILE I 603 CYS I 604 0 SHEET 2 AB5 3 TRP F 35 TYR F 39 -1 O VAL F 38 N CYS I 604 SHEET 3 AB5 3 GLY F 495 THR F 499 -1 O THR F 499 N TRP F 35 SHEET 1 AB6 4 THR D 5 ILE D 7 0 SHEET 2 AB6 4 SER D 20 SER D 24 -1 O SER D 22 N ILE D 7 SHEET 3 AB6 4 ASP D 70 ILE D 75 -1 O PHE D 71 N CYS D 23 SHEET 4 AB6 4 PHE D 62 SER D 63 -1 N SER D 63 O LYS D 74 SHEET 1 AB7 5 SER D 10 VAL D 13 0 SHEET 2 AB7 5 THR D 102 ILE D 106 1 O GLU D 105 N LEU D 11 SHEET 3 AB7 5 ILE D 85 GLN D 90 -1 N TYR D 86 O THR D 102 SHEET 4 AB7 5 LEU D 33 GLN D 38 -1 N GLN D 38 O ILE D 85 SHEET 5 AB7 5 GLN D 45 ILE D 48 -1 O LEU D 47 N TRP D 35 SHEET 1 AB8 4 GLN H 5 SER H 7 0 SHEET 2 AB8 4 LEU H 18 ALA H 23 -1 O ALA H 23 N GLN H 5 SHEET 3 AB8 4 GLN H 78 LEU H 83 -1 O LEU H 83 N LEU H 18 SHEET 4 AB8 4 THR H 69 ASP H 73 -1 N THR H 69 O ILE H 82 SHEET 1 AB9 2 LEU H 11 LEU H 12 0 SHEET 2 AB9 2 THR H 111 VAL H 112 1 O THR H 111 N LEU H 12 SHEET 1 AC1 3 GLU H 46 ARG H 50 0 SHEET 2 AC1 3 TRP H 34 ARG H 38 -1 N TRP H 36 O GLY H 49 SHEET 3 AC1 3 TYR H 91 ARG H 95 -1 O TYR H 92 N ILE H 37 SHEET 1 AC2 2 TYR H 99 TRP H 100 0 SHEET 2 AC2 2 GLN H 101J TRP H 101K-1 O GLN H 101J N TRP H 100 SHEET 1 AC3 3 ILE J 603 CYS J 604 0 SHEET 2 AC3 3 TRP L 35 TYR L 39 -1 O VAL L 38 N CYS J 604 SHEET 3 AC3 3 GLY L 495 THR L 499 -1 O THR L 499 N TRP L 35 SHEET 1 AC4 2 TRP L 45 LYS L 46 0 SHEET 2 AC4 2 LYS L 490 ILE L 491 -1 O LYS L 490 N LYS L 46 SHEET 1 AC5 4 ILE L 84 HIS L 85 0 SHEET 2 AC5 4 VAL L 242 VAL L 245 -1 O THR L 244 N ILE L 84 SHEET 3 AC5 4 ILE L 225 CYS L 228 -1 N LYS L 227 O SER L 243 SHEET 4 AC5 4 TYR L 486 VAL L 488 -1 O LYS L 487 N LEU L 226 SHEET 1 AC6 2 GLU L 91 PHE L 93 0 SHEET 2 AC6 2 GLY L 237 CYS L 239 -1 O CYS L 239 N GLU L 91 SHEET 1 AC7 3 THR L 132 ASN L 133 0 SHEET 2 AC7 3 LEU L 154 THR L 162 -1 O ASN L 156 N THR L 132 SHEET 3 AC7 3 LYS L 169 TYR L 177 -1 O GLN L 170 N MET L 161 SHEET 1 AC8 2 VAL L 181 GLN L 183 0 SHEET 2 AC8 2 TYR L 191 LEU L 193 -1 O ARG L 192 N VAL L 182 SHEET 1 AC9 6 ILE L 272 ARG L 273 0 SHEET 2 AC9 6 ILE L 284 THR L 297 -1 O LEU L 285 N ARG L 273 SHEET 3 AC9 6 ARG L 444 THR L 455 -1 O LEU L 452 N VAL L 286 SHEET 4 AC9 6 THR L 465 PRO L 470 -1 O ARG L 469 N THR L 455 SHEET 5 AC9 6 ILE L 358 PHE L 361 1 N ILE L 358 O GLU L 466 SHEET 6 AC9 6 THR L 394 TRP L 395 -1 O TRP L 395 N ILE L 359 SHEET 1 AD1 4 ILE L 272 ARG L 273 0 SHEET 2 AD1 4 ILE L 284 THR L 297 -1 O LEU L 285 N ARG L 273 SHEET 3 AD1 4 HIS L 330 SER L 334 -1 O ASN L 332 N ASN L 295 SHEET 4 AD1 4 SER L 413 PRO L 417 -1 O ILE L 414 N VAL L 333 SHEET 1 AD2 2 ARG L 304 GLY L 312 0 SHEET 2 AD2 2 GLN L 315 THR L 320 -1 O PHE L 317 N ILE L 307 SHEET 1 AD3 2 HIS L 374 CYS L 378 0 SHEET 2 AD3 2 GLU L 381 CYS L 385 -1 O PHE L 383 N PHE L 376 SHEET 1 AD4 2 TRP F 45 LYS F 46 0 SHEET 2 AD4 2 LYS F 490 ILE F 491 -1 O LYS F 490 N LYS F 46 SHEET 1 AD5 4 ILE F 84 HIS F 85 0 SHEET 2 AD5 4 VAL F 242 VAL F 245 -1 O THR F 244 N ILE F 84 SHEET 3 AD5 4 ILE F 225 CYS F 228 -1 N LYS F 227 O SER F 243 SHEET 4 AD5 4 TYR F 486 VAL F 488 -1 O LYS F 487 N LEU F 226 SHEET 1 AD6 2 GLU F 91 PHE F 93 0 SHEET 2 AD6 2 GLY F 237 CYS F 239 -1 O CYS F 239 N GLU F 91 SHEET 1 AD7 3 THR F 132 ASN F 133 0 SHEET 2 AD7 3 LEU F 154 THR F 162 -1 O ASN F 156 N THR F 132 SHEET 3 AD7 3 LYS F 169 TYR F 177 -1 O GLN F 170 N MET F 161 SHEET 1 AD8 2 VAL F 181 GLN F 183 0 SHEET 2 AD8 2 TYR F 191 LEU F 193 -1 O ARG F 192 N VAL F 182 SHEET 1 AD9 6 ILE F 272 ARG F 273 0 SHEET 2 AD9 6 ILE F 284 THR F 297 -1 O LEU F 285 N ARG F 273 SHEET 3 AD9 6 ARG F 444 THR F 455 -1 O LEU F 452 N VAL F 286 SHEET 4 AD9 6 THR F 465 PRO F 470 -1 O ARG F 469 N THR F 455 SHEET 5 AD9 6 ILE F 358 PHE F 361 1 N ILE F 358 O GLU F 466 SHEET 6 AD9 6 THR F 394 TRP F 395 -1 O TRP F 395 N ILE F 359 SHEET 1 AE1 4 ILE F 272 ARG F 273 0 SHEET 2 AE1 4 ILE F 284 THR F 297 -1 O LEU F 285 N ARG F 273 SHEET 3 AE1 4 HIS F 330 SER F 334 -1 O ASN F 332 N ASN F 295 SHEET 4 AE1 4 SER F 413 PRO F 417 -1 O ILE F 414 N VAL F 333 SHEET 1 AE2 2 ARG F 304 GLY F 312 0 SHEET 2 AE2 2 GLN F 315 THR F 320 -1 O PHE F 317 N ILE F 307 SHEET 1 AE3 2 HIS F 374 CYS F 378 0 SHEET 2 AE3 2 GLU F 381 CYS F 385 -1 O PHE F 383 N PHE F 376 SHEET 1 AE4 2 TRP K 45 LYS K 46 0 SHEET 2 AE4 2 LYS K 490 ILE K 491 -1 O LYS K 490 N LYS K 46 SHEET 1 AE5 4 ILE K 84 HIS K 85 0 SHEET 2 AE5 4 VAL K 242 VAL K 245 -1 O THR K 244 N ILE K 84 SHEET 3 AE5 4 ILE K 225 CYS K 228 -1 N LYS K 227 O SER K 243 SHEET 4 AE5 4 TYR K 486 VAL K 488 -1 O LYS K 487 N LEU K 226 SHEET 1 AE6 2 GLU K 91 PHE K 93 0 SHEET 2 AE6 2 GLY K 237 CYS K 239 -1 O CYS K 239 N GLU K 91 SHEET 1 AE7 3 THR K 132 ASN K 133 0 SHEET 2 AE7 3 LEU K 154 THR K 162 -1 O ASN K 156 N THR K 132 SHEET 3 AE7 3 LYS K 169 TYR K 177 -1 O GLN K 170 N MET K 161 SHEET 1 AE8 2 VAL K 181 GLN K 183 0 SHEET 2 AE8 2 TYR K 191 LEU K 193 -1 O ARG K 192 N VAL K 182 SHEET 1 AE9 6 ILE K 272 ARG K 273 0 SHEET 2 AE9 6 ILE K 284 THR K 297 -1 O LEU K 285 N ARG K 273 SHEET 3 AE9 6 ARG K 444 THR K 455 -1 O LEU K 452 N VAL K 286 SHEET 4 AE9 6 THR K 465 PRO K 470 -1 O ARG K 469 N THR K 455 SHEET 5 AE9 6 ILE K 358 PHE K 361 1 N ILE K 358 O GLU K 466 SHEET 6 AE9 6 THR K 394 TRP K 395 -1 O TRP K 395 N ILE K 359 SHEET 1 AF1 4 ILE K 272 ARG K 273 0 SHEET 2 AF1 4 ILE K 284 THR K 297 -1 O LEU K 285 N ARG K 273 SHEET 3 AF1 4 HIS K 330 SER K 334 -1 O ASN K 332 N ASN K 295 SHEET 4 AF1 4 SER K 413 PRO K 417 -1 O ILE K 414 N VAL K 333 SHEET 1 AF2 2 ARG K 304 GLY K 312 0 SHEET 2 AF2 2 GLN K 315 THR K 320 -1 O PHE K 317 N ILE K 307 SHEET 1 AF3 2 HIS K 374 CYS K 378 0 SHEET 2 AF3 2 GLU K 381 CYS K 385 -1 O PHE K 383 N PHE K 376 SSBOND 1 CYS A 23 CYS A 88 1555 1555 2.03 SSBOND 2 CYS C 22 CYS C 93 1555 1555 2.03 SSBOND 3 CYS E 598 CYS E 604 1555 1555 2.03 SSBOND 4 CYS E 605 CYS K 501 1555 1555 2.03 SSBOND 5 CYS B 23 CYS B 88 1555 1555 2.03 SSBOND 6 CYS G 22 CYS G 93 1555 1555 2.03 SSBOND 7 CYS I 598 CYS I 604 1555 1555 2.03 SSBOND 8 CYS I 605 CYS F 501 1555 1555 2.03 SSBOND 9 CYS D 23 CYS D 88 1555 1555 2.03 SSBOND 10 CYS H 22 CYS H 93 1555 1555 2.03 SSBOND 11 CYS J 598 CYS J 604 1555 1555 2.03 SSBOND 12 CYS J 605 CYS L 501 1555 1555 2.03 SSBOND 13 CYS L 54 CYS L 74 1555 1555 2.04 SSBOND 14 CYS L 119 CYS L 205 1555 1555 2.04 SSBOND 15 CYS L 126 CYS L 196 1555 1555 2.03 SSBOND 16 CYS L 131 CYS L 157 1555 1555 2.03 SSBOND 17 CYS L 201 CYS L 433 1555 1555 2.03 SSBOND 18 CYS L 218 CYS L 247 1555 1555 2.03 SSBOND 19 CYS L 228 CYS L 239 1555 1555 2.03 SSBOND 20 CYS L 296 CYS L 331 1555 1555 2.03 SSBOND 21 CYS L 378 CYS L 445 1555 1555 2.03 SSBOND 22 CYS L 385 CYS L 418 1555 1555 2.03 SSBOND 23 CYS F 54 CYS F 74 1555 1555 2.04 SSBOND 24 CYS F 119 CYS F 205 1555 1555 2.04 SSBOND 25 CYS F 126 CYS F 196 1555 1555 2.03 SSBOND 26 CYS F 131 CYS F 157 1555 1555 2.03 SSBOND 27 CYS F 201 CYS F 433 1555 1555 2.03 SSBOND 28 CYS F 218 CYS F 247 1555 1555 2.03 SSBOND 29 CYS F 228 CYS F 239 1555 1555 2.03 SSBOND 30 CYS F 296 CYS F 331 1555 1555 2.03 SSBOND 31 CYS F 378 CYS F 445 1555 1555 2.03 SSBOND 32 CYS F 385 CYS F 418 1555 1555 2.03 SSBOND 33 CYS K 54 CYS K 74 1555 1555 2.04 SSBOND 34 CYS K 119 CYS K 205 1555 1555 2.04 SSBOND 35 CYS K 126 CYS K 196 1555 1555 2.03 SSBOND 36 CYS K 131 CYS K 157 1555 1555 2.03 SSBOND 37 CYS K 201 CYS K 433 1555 1555 2.03 SSBOND 38 CYS K 218 CYS K 247 1555 1555 2.03 SSBOND 39 CYS K 228 CYS K 239 1555 1555 2.03 SSBOND 40 CYS K 296 CYS K 331 1555 1555 2.03 SSBOND 41 CYS K 378 CYS K 445 1555 1555 2.03 SSBOND 42 CYS K 385 CYS K 418 1555 1555 2.03 LINK ND2 ASN E 611 C1 NAG E 701 1555 1555 1.44 LINK ND2 ASN E 637 C1 NAG E 702 1555 1555 1.44 LINK ND2 ASN I 611 C1 NAG I 701 1555 1555 1.44 LINK ND2 ASN I 637 C1 NAG I 702 1555 1555 1.44 LINK ND2 ASN J 611 C1 NAG J 701 1555 1555 1.44 LINK ND2 ASN J 637 C1 NAG J 702 1555 1555 1.44 LINK ND2 ASN L 88 C1 NAG L 601 1555 1555 1.44 LINK ND2 ASN L 133 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN L 137 C1 NAG L 605 1555 1555 1.44 LINK ND2 ASN L 156 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN L 160 C1 NAG L 607 1555 1555 1.44 LINK ND2 ASN L 197 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN L 234 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN L 262 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN L 276 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN L 295 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN L 301 C1 NAG L 602 1555 1555 1.44 LINK ND2 ASN L 332 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN L 339 C1 NAG L 603 1555 1555 1.44 LINK ND2 ASN L 355 C1 NAG L 604 1555 1555 1.44 LINK ND2 ASN L 363 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN L 386 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN L 392 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN L 448 C1 NAG L 606 1555 1555 1.44 LINK ND2 ASN L 462 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN F 88 C1 NAG F 601 1555 1555 1.44 LINK ND2 ASN F 133 C1 NAG g 1 1555 1555 1.44 LINK ND2 ASN F 137 C1 NAG F 605 1555 1555 1.44 LINK ND2 ASN F 156 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN F 160 C1 NAG F 607 1555 1555 1.44 LINK ND2 ASN F 197 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN F 234 C1 NAG i 1 1555 1555 1.44 LINK ND2 ASN F 262 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN F 276 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN F 295 C1 NAG h 1 1555 1555 1.44 LINK ND2 ASN F 301 C1 NAG F 602 1555 1555 1.44 LINK ND2 ASN F 332 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN F 339 C1 NAG F 603 1555 1555 1.44 LINK ND2 ASN F 355 C1 NAG F 604 1555 1555 1.44 LINK ND2 ASN F 363 C1 NAG e 1 1555 1555 1.44 LINK ND2 ASN F 386 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN F 392 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN F 448 C1 NAG F 606 1555 1555 1.44 LINK ND2 ASN F 462 C1 NAG j 1 1555 1555 1.44 LINK ND2 ASN K 88 C1 NAG K 601 1555 1555 1.44 LINK ND2 ASN K 133 C1 NAG s 1 1555 1555 1.44 LINK ND2 ASN K 137 C1 NAG K 605 1555 1555 1.44 LINK ND2 ASN K 156 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN K 160 C1 NAG K 607 1555 1555 1.44 LINK ND2 ASN K 197 C1 NAG r 1 1555 1555 1.44 LINK ND2 ASN K 234 C1 NAG u 1 1555 1555 1.44 LINK ND2 ASN K 262 C1 NAG l 1 1555 1555 1.44 LINK ND2 ASN K 276 C1 NAG p 1 1555 1555 1.44 LINK ND2 ASN K 295 C1 NAG t 1 1555 1555 1.44 LINK ND2 ASN K 301 C1 NAG K 602 1555 1555 1.44 LINK ND2 ASN K 332 C1 NAG m 1 1555 1555 1.44 LINK ND2 ASN K 339 C1 NAG K 603 1555 1555 1.44 LINK ND2 ASN K 355 C1 NAG K 604 1555 1555 1.44 LINK ND2 ASN K 363 C1 NAG q 1 1555 1555 1.44 LINK ND2 ASN K 386 C1 NAG o 1 1555 1555 1.44 LINK ND2 ASN K 392 C1 NAG n 1 1555 1555 1.44 LINK ND2 ASN K 448 C1 NAG K 606 1555 1555 1.44 LINK ND2 ASN K 462 C1 NAG v 1 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG N 2 C1 BMA N 3 1555 1555 1.45 LINK O3 BMA N 3 C1 MAN N 4 1555 1555 1.45 LINK O6 BMA N 3 C1 MAN N 5 1555 1555 1.46 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG Q 2 C1 BMA Q 3 1555 1555 1.44 LINK O3 BMA Q 3 C1 MAN Q 4 1555 1555 1.46 LINK O6 BMA Q 3 C1 MAN Q 5 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG R 2 C1 BMA R 3 1555 1555 1.45 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG S 2 C1 BMA S 3 1555 1555 1.44 LINK O3 BMA S 3 C1 MAN S 4 1555 1555 1.46 LINK O6 BMA S 3 C1 MAN S 5 1555 1555 1.45 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG V 2 C1 BMA V 3 1555 1555 1.45 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG W 2 C1 BMA W 3 1555 1555 1.45 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG Z 2 C1 BMA Z 3 1555 1555 1.45 LINK O3 BMA Z 3 C1 MAN Z 4 1555 1555 1.45 LINK O6 BMA Z 3 C1 MAN Z 5 1555 1555 1.46 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.44 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.44 LINK O4 NAG b 2 C1 BMA b 3 1555 1555 1.44 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.44 LINK O4 NAG c 2 C1 BMA c 3 1555 1555 1.44 LINK O3 BMA c 3 C1 MAN c 4 1555 1555 1.46 LINK O6 BMA c 3 C1 MAN c 5 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.44 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.45 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.44 LINK O4 NAG e 2 C1 BMA e 3 1555 1555 1.44 LINK O3 BMA e 3 C1 MAN e 4 1555 1555 1.46 LINK O6 BMA e 3 C1 MAN e 5 1555 1555 1.45 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.44 LINK O4 NAG f 2 C1 BMA f 3 1555 1555 1.44 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.44 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.44 LINK O4 NAG h 2 C1 BMA h 3 1555 1555 1.45 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.44 LINK O4 NAG i 2 C1 BMA i 3 1555 1555 1.45 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.44 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.44 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.44 LINK O4 NAG l 2 C1 BMA l 3 1555 1555 1.45 LINK O3 BMA l 3 C1 MAN l 4 1555 1555 1.45 LINK O6 BMA l 3 C1 MAN l 5 1555 1555 1.46 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.44 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.44 LINK O4 NAG n 2 C1 BMA n 3 1555 1555 1.44 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.44 LINK O4 NAG o 2 C1 BMA o 3 1555 1555 1.44 LINK O3 BMA o 3 C1 MAN o 4 1555 1555 1.46 LINK O6 BMA o 3 C1 MAN o 5 1555 1555 1.44 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.44 LINK O4 NAG p 2 C1 BMA p 3 1555 1555 1.44 LINK O4 NAG q 1 C1 NAG q 2 1555 1555 1.44 LINK O4 NAG q 2 C1 BMA q 3 1555 1555 1.44 LINK O3 BMA q 3 C1 MAN q 4 1555 1555 1.46 LINK O6 BMA q 3 C1 MAN q 5 1555 1555 1.45 LINK O4 NAG r 1 C1 NAG r 2 1555 1555 1.44 LINK O4 NAG r 2 C1 BMA r 3 1555 1555 1.44 LINK O4 NAG s 1 C1 NAG s 2 1555 1555 1.44 LINK O4 NAG t 1 C1 NAG t 2 1555 1555 1.44 LINK O4 NAG t 2 C1 BMA t 3 1555 1555 1.45 LINK O4 NAG u 1 C1 NAG u 2 1555 1555 1.44 LINK O4 NAG u 2 C1 BMA u 3 1555 1555 1.45 LINK O4 NAG v 1 C1 NAG v 2 1555 1555 1.44 CISPEP 1 ILE A 7 PRO A 8 0 -4.67 CISPEP 2 ILE B 7 PRO B 8 0 -4.69 CISPEP 3 ILE D 7 PRO D 8 0 -4.64 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000