HEADER MEMBRANE PROTEIN 16-OCT-24 9DZJ TITLE HUMAN GC-A BOUND TO ANP AND 2XREGN5308 COMPND MOL_ID: 1; COMPND 2 MOLECULE: REGN5308 - HEAVY CHAIN; COMPND 3 CHAIN: H, G; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: REGN5308 - LIGHT CHAIN; COMPND 7 CHAIN: L, K; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1; COMPND 11 CHAIN: A, B; COMPND 12 SYNONYM: ATRIAL NATRIURETIC PEPTIDE RECEPTOR TYPE A,ANP-A,ANPR-A,NPR- COMPND 13 A,GUANYLATE CYCLASE A,GC-A; COMPND 14 EC: 4.6.1.2; COMPND 15 ENGINEERED: YES; COMPND 16 MOL_ID: 4; COMPND 17 MOLECULE: ATRIAL NATRIURETIC PEPTIDE; COMPND 18 CHAIN: C; COMPND 19 FRAGMENT: UNP RESIDUES 124-151; COMPND 20 SYNONYM: ANP,ALPHA-ATRIAL NATRIURETIC PEPTIDE,ALPHA-HANP,ATRIAL COMPND 21 NATRIURETIC FACTOR,ANF,CDD-ANF,CDD-ANP (99-126),CARDIONATRIN,PRO COMPND 22 ATRIAL NATRIURETIC FACTOR 99-126,PROANF 99-126; COMPND 23 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 3 ORGANISM_TAXID: 10090; SOURCE 4 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 8 ORGANISM_TAXID: 10090; SOURCE 9 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_COMMON: HUMAN; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 GENE: NPR1, ANPRA; SOURCE 16 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 18 MOL_ID: 4; SOURCE 19 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 20 ORGANISM_COMMON: HUMAN; SOURCE 21 ORGANISM_TAXID: 9606; SOURCE 22 GENE: NPPA, ANP, PND; SOURCE 23 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 24 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS RECEPTOR, MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR S.LIU,X.-Y.HUANG REVDAT 1 21-JAN-26 9DZJ 0 JRNL AUTH S.LIU,X.-Y.HUANG JRNL TITL HUMAN NPR1 BOUND TO ANP AND 2XRGN5308 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.70 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.700 REMARK 3 NUMBER OF PARTICLES : 211000 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9DZJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 17-OCT-24. REMARK 100 THE DEPOSITION ID IS D_1000289170. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : RGN5308 BOUND TO NPR1-ANP REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEPTAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEPTAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, G, K, A, B, C, E, D, F, REMARK 350 AND CHAINS: I, J, M REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA H 125 REMARK 465 SER H 126 REMARK 465 THR H 127 REMARK 465 LYS H 128 REMARK 465 GLY H 129 REMARK 465 PRO H 130 REMARK 465 SER H 131 REMARK 465 VAL H 132 REMARK 465 PHE H 133 REMARK 465 PRO H 134 REMARK 465 LEU H 135 REMARK 465 ALA H 136 REMARK 465 PRO H 137 REMARK 465 SER H 138 REMARK 465 SER H 139 REMARK 465 LYS H 140 REMARK 465 SER H 141 REMARK 465 THR H 142 REMARK 465 SER H 143 REMARK 465 GLY H 144 REMARK 465 GLY H 145 REMARK 465 THR H 146 REMARK 465 ALA H 147 REMARK 465 ALA H 148 REMARK 465 LEU H 149 REMARK 465 GLY H 150 REMARK 465 CYS H 151 REMARK 465 LEU H 152 REMARK 465 VAL H 153 REMARK 465 LYS H 154 REMARK 465 ASP H 155 REMARK 465 TYR H 156 REMARK 465 PHE H 157 REMARK 465 PRO H 158 REMARK 465 GLU H 159 REMARK 465 PRO H 160 REMARK 465 VAL H 161 REMARK 465 THR H 162 REMARK 465 VAL H 163 REMARK 465 SER H 164 REMARK 465 TRP H 165 REMARK 465 ASN H 166 REMARK 465 SER H 167 REMARK 465 GLY H 168 REMARK 465 ALA H 169 REMARK 465 LEU H 170 REMARK 465 THR H 171 REMARK 465 SER H 172 REMARK 465 GLY H 173 REMARK 465 VAL H 174 REMARK 465 HIS H 175 REMARK 465 THR H 176 REMARK 465 PHE H 177 REMARK 465 PRO H 178 REMARK 465 ALA H 179 REMARK 465 VAL H 180 REMARK 465 LEU H 181 REMARK 465 GLN H 182 REMARK 465 SER H 183 REMARK 465 SER H 184 REMARK 465 GLY H 185 REMARK 465 LEU H 186 REMARK 465 TYR H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 SER H 190 REMARK 465 SER H 191 REMARK 465 VAL H 192 REMARK 465 VAL H 193 REMARK 465 THR H 194 REMARK 465 VAL H 195 REMARK 465 PRO H 196 REMARK 465 SER H 197 REMARK 465 SER H 198 REMARK 465 SER H 199 REMARK 465 LEU H 200 REMARK 465 GLY H 201 REMARK 465 THR H 202 REMARK 465 GLN H 203 REMARK 465 THR H 204 REMARK 465 TYR H 205 REMARK 465 ILE H 206 REMARK 465 CYS H 207 REMARK 465 ASN H 208 REMARK 465 VAL H 209 REMARK 465 ASN H 210 REMARK 465 HIS H 211 REMARK 465 LYS H 212 REMARK 465 PRO H 213 REMARK 465 SER H 214 REMARK 465 ASN H 215 REMARK 465 THR H 216 REMARK 465 LYS H 217 REMARK 465 VAL H 218 REMARK 465 ASP H 219 REMARK 465 LYS H 220 REMARK 465 ARG H 221 REMARK 465 VAL H 222 REMARK 465 GLU H 223 REMARK 465 PRO H 224 REMARK 465 LYS H 225 REMARK 465 SER H 226 REMARK 465 CYS H 227 REMARK 465 ARG L 107 REMARK 465 THR L 108 REMARK 465 VAL L 109 REMARK 465 ALA L 110 REMARK 465 ALA L 111 REMARK 465 PRO L 112 REMARK 465 SER L 113 REMARK 465 VAL L 114 REMARK 465 PHE L 115 REMARK 465 ILE L 116 REMARK 465 PHE L 117 REMARK 465 PRO L 118 REMARK 465 PRO L 119 REMARK 465 SER L 120 REMARK 465 ASP L 121 REMARK 465 GLU L 122 REMARK 465 GLN L 123 REMARK 465 LEU L 124 REMARK 465 LYS L 125 REMARK 465 SER L 126 REMARK 465 GLY L 127 REMARK 465 THR L 128 REMARK 465 ALA L 129 REMARK 465 SER L 130 REMARK 465 VAL L 131 REMARK 465 VAL L 132 REMARK 465 CYS L 133 REMARK 465 LEU L 134 REMARK 465 LEU L 135 REMARK 465 ASN L 136 REMARK 465 ASN L 137 REMARK 465 PHE L 138 REMARK 465 TYR L 139 REMARK 465 PRO L 140 REMARK 465 ARG L 141 REMARK 465 GLU L 142 REMARK 465 ALA L 143 REMARK 465 LYS L 144 REMARK 465 VAL L 145 REMARK 465 GLN L 146 REMARK 465 TRP L 147 REMARK 465 LYS L 148 REMARK 465 VAL L 149 REMARK 465 ASP L 150 REMARK 465 ASN L 151 REMARK 465 ALA L 152 REMARK 465 LEU L 153 REMARK 465 GLN L 154 REMARK 465 SER L 155 REMARK 465 GLY L 156 REMARK 465 ASN L 157 REMARK 465 SER L 158 REMARK 465 GLN L 159 REMARK 465 GLU L 160 REMARK 465 SER L 161 REMARK 465 VAL L 162 REMARK 465 THR L 163 REMARK 465 GLU L 164 REMARK 465 GLN L 165 REMARK 465 ASP L 166 REMARK 465 SER L 167 REMARK 465 LYS L 168 REMARK 465 ASP L 169 REMARK 465 SER L 170 REMARK 465 THR L 171 REMARK 465 TYR L 172 REMARK 465 SER L 173 REMARK 465 LEU L 174 REMARK 465 SER L 175 REMARK 465 SER L 176 REMARK 465 THR L 177 REMARK 465 LEU L 178 REMARK 465 THR L 179 REMARK 465 LEU L 180 REMARK 465 SER L 181 REMARK 465 LYS L 182 REMARK 465 ALA L 183 REMARK 465 ASP L 184 REMARK 465 TYR L 185 REMARK 465 GLU L 186 REMARK 465 LYS L 187 REMARK 465 HIS L 188 REMARK 465 LYS L 189 REMARK 465 VAL L 190 REMARK 465 TYR L 191 REMARK 465 ALA L 192 REMARK 465 CYS L 193 REMARK 465 GLU L 194 REMARK 465 VAL L 195 REMARK 465 THR L 196 REMARK 465 HIS L 197 REMARK 465 GLN L 198 REMARK 465 GLY L 199 REMARK 465 LEU L 200 REMARK 465 SER L 201 REMARK 465 SER L 202 REMARK 465 PRO L 203 REMARK 465 VAL L 204 REMARK 465 THR L 205 REMARK 465 LYS L 206 REMARK 465 SER L 207 REMARK 465 PHE L 208 REMARK 465 ASN L 209 REMARK 465 ARG L 210 REMARK 465 GLY L 211 REMARK 465 GLU L 212 REMARK 465 CYS L 213 REMARK 465 ALA G 125 REMARK 465 SER G 126 REMARK 465 THR G 127 REMARK 465 LYS G 128 REMARK 465 GLY G 129 REMARK 465 PRO G 130 REMARK 465 SER G 131 REMARK 465 VAL G 132 REMARK 465 PHE G 133 REMARK 465 PRO G 134 REMARK 465 LEU G 135 REMARK 465 ALA G 136 REMARK 465 PRO G 137 REMARK 465 SER G 138 REMARK 465 SER G 139 REMARK 465 LYS G 140 REMARK 465 SER G 141 REMARK 465 THR G 142 REMARK 465 SER G 143 REMARK 465 GLY G 144 REMARK 465 GLY G 145 REMARK 465 THR G 146 REMARK 465 ALA G 147 REMARK 465 ALA G 148 REMARK 465 LEU G 149 REMARK 465 GLY G 150 REMARK 465 CYS G 151 REMARK 465 LEU G 152 REMARK 465 VAL G 153 REMARK 465 LYS G 154 REMARK 465 ASP G 155 REMARK 465 TYR G 156 REMARK 465 PHE G 157 REMARK 465 PRO G 158 REMARK 465 GLU G 159 REMARK 465 PRO G 160 REMARK 465 VAL G 161 REMARK 465 THR G 162 REMARK 465 VAL G 163 REMARK 465 SER G 164 REMARK 465 TRP G 165 REMARK 465 ASN G 166 REMARK 465 SER G 167 REMARK 465 GLY G 168 REMARK 465 ALA G 169 REMARK 465 LEU G 170 REMARK 465 THR G 171 REMARK 465 SER G 172 REMARK 465 GLY G 173 REMARK 465 VAL G 174 REMARK 465 HIS G 175 REMARK 465 THR G 176 REMARK 465 PHE G 177 REMARK 465 PRO G 178 REMARK 465 ALA G 179 REMARK 465 VAL G 180 REMARK 465 LEU G 181 REMARK 465 GLN G 182 REMARK 465 SER G 183 REMARK 465 SER G 184 REMARK 465 GLY G 185 REMARK 465 LEU G 186 REMARK 465 TYR G 187 REMARK 465 SER G 188 REMARK 465 LEU G 189 REMARK 465 SER G 190 REMARK 465 SER G 191 REMARK 465 VAL G 192 REMARK 465 VAL G 193 REMARK 465 THR G 194 REMARK 465 VAL G 195 REMARK 465 PRO G 196 REMARK 465 SER G 197 REMARK 465 SER G 198 REMARK 465 SER G 199 REMARK 465 LEU G 200 REMARK 465 GLY G 201 REMARK 465 THR G 202 REMARK 465 GLN G 203 REMARK 465 THR G 204 REMARK 465 TYR G 205 REMARK 465 ILE G 206 REMARK 465 CYS G 207 REMARK 465 ASN G 208 REMARK 465 VAL G 209 REMARK 465 ASN G 210 REMARK 465 HIS G 211 REMARK 465 LYS G 212 REMARK 465 PRO G 213 REMARK 465 SER G 214 REMARK 465 ASN G 215 REMARK 465 THR G 216 REMARK 465 LYS G 217 REMARK 465 VAL G 218 REMARK 465 ASP G 219 REMARK 465 LYS G 220 REMARK 465 ARG G 221 REMARK 465 VAL G 222 REMARK 465 GLU G 223 REMARK 465 PRO G 224 REMARK 465 LYS G 225 REMARK 465 SER G 226 REMARK 465 CYS G 227 REMARK 465 ARG K 107 REMARK 465 THR K 108 REMARK 465 VAL K 109 REMARK 465 ALA K 110 REMARK 465 ALA K 111 REMARK 465 PRO K 112 REMARK 465 SER K 113 REMARK 465 VAL K 114 REMARK 465 PHE K 115 REMARK 465 ILE K 116 REMARK 465 PHE K 117 REMARK 465 PRO K 118 REMARK 465 PRO K 119 REMARK 465 SER K 120 REMARK 465 ASP K 121 REMARK 465 GLU K 122 REMARK 465 GLN K 123 REMARK 465 LEU K 124 REMARK 465 LYS K 125 REMARK 465 SER K 126 REMARK 465 GLY K 127 REMARK 465 THR K 128 REMARK 465 ALA K 129 REMARK 465 SER K 130 REMARK 465 VAL K 131 REMARK 465 VAL K 132 REMARK 465 CYS K 133 REMARK 465 LEU K 134 REMARK 465 LEU K 135 REMARK 465 ASN K 136 REMARK 465 ASN K 137 REMARK 465 PHE K 138 REMARK 465 TYR K 139 REMARK 465 PRO K 140 REMARK 465 ARG K 141 REMARK 465 GLU K 142 REMARK 465 ALA K 143 REMARK 465 LYS K 144 REMARK 465 VAL K 145 REMARK 465 GLN K 146 REMARK 465 TRP K 147 REMARK 465 LYS K 148 REMARK 465 VAL K 149 REMARK 465 ASP K 150 REMARK 465 ASN K 151 REMARK 465 ALA K 152 REMARK 465 LEU K 153 REMARK 465 GLN K 154 REMARK 465 SER K 155 REMARK 465 GLY K 156 REMARK 465 ASN K 157 REMARK 465 SER K 158 REMARK 465 GLN K 159 REMARK 465 GLU K 160 REMARK 465 SER K 161 REMARK 465 VAL K 162 REMARK 465 THR K 163 REMARK 465 GLU K 164 REMARK 465 GLN K 165 REMARK 465 ASP K 166 REMARK 465 SER K 167 REMARK 465 LYS K 168 REMARK 465 ASP K 169 REMARK 465 SER K 170 REMARK 465 THR K 171 REMARK 465 TYR K 172 REMARK 465 SER K 173 REMARK 465 LEU K 174 REMARK 465 SER K 175 REMARK 465 SER K 176 REMARK 465 THR K 177 REMARK 465 LEU K 178 REMARK 465 THR K 179 REMARK 465 LEU K 180 REMARK 465 SER K 181 REMARK 465 LYS K 182 REMARK 465 ALA K 183 REMARK 465 ASP K 184 REMARK 465 TYR K 185 REMARK 465 GLU K 186 REMARK 465 LYS K 187 REMARK 465 HIS K 188 REMARK 465 LYS K 189 REMARK 465 VAL K 190 REMARK 465 TYR K 191 REMARK 465 ALA K 192 REMARK 465 CYS K 193 REMARK 465 GLU K 194 REMARK 465 VAL K 195 REMARK 465 THR K 196 REMARK 465 HIS K 197 REMARK 465 GLN K 198 REMARK 465 GLY K 199 REMARK 465 LEU K 200 REMARK 465 SER K 201 REMARK 465 SER K 202 REMARK 465 PRO K 203 REMARK 465 VAL K 204 REMARK 465 THR K 205 REMARK 465 LYS K 206 REMARK 465 SER K 207 REMARK 465 PHE K 208 REMARK 465 ASN K 209 REMARK 465 ARG K 210 REMARK 465 GLY K 211 REMARK 465 GLU K 212 REMARK 465 CYS K 213 REMARK 465 ASP A 426 REMARK 465 ASN A 427 REMARK 465 GLU A 428 REMARK 465 ASP A 429 REMARK 465 PRO A 430 REMARK 465 ALA A 431 REMARK 465 CYS A 432 REMARK 465 ASN A 433 REMARK 465 GLN A 434 REMARK 465 ASP A 435 REMARK 465 HIS A 436 REMARK 465 LEU A 437 REMARK 465 SER A 438 REMARK 465 THR A 439 REMARK 465 LEU A 440 REMARK 465 GLU A 441 REMARK 465 VAL A 442 REMARK 465 LEU A 443 REMARK 465 ALA A 444 REMARK 465 LEU A 445 REMARK 465 VAL A 446 REMARK 465 GLY A 447 REMARK 465 SER A 448 REMARK 465 LEU A 449 REMARK 465 SER A 450 REMARK 465 LEU A 451 REMARK 465 LEU A 452 REMARK 465 GLY A 453 REMARK 465 ILE A 454 REMARK 465 LEU A 455 REMARK 465 ILE A 456 REMARK 465 VAL A 457 REMARK 465 SER A 458 REMARK 465 PHE A 459 REMARK 465 PHE A 460 REMARK 465 ILE A 461 REMARK 465 TYR A 462 REMARK 465 ARG A 463 REMARK 465 LYS A 464 REMARK 465 MET A 465 REMARK 465 GLN A 466 REMARK 465 LEU A 467 REMARK 465 GLU A 468 REMARK 465 LYS A 469 REMARK 465 GLU A 470 REMARK 465 LEU A 471 REMARK 465 ALA A 472 REMARK 465 SER A 473 REMARK 465 GLU A 474 REMARK 465 LEU A 475 REMARK 465 TRP A 476 REMARK 465 ARG A 477 REMARK 465 VAL A 478 REMARK 465 ARG A 479 REMARK 465 TRP A 480 REMARK 465 GLU A 481 REMARK 465 ASP A 482 REMARK 465 VAL A 483 REMARK 465 GLU A 484 REMARK 465 PRO A 485 REMARK 465 SER A 486 REMARK 465 SER A 487 REMARK 465 LEU A 488 REMARK 465 GLU A 489 REMARK 465 ARG A 490 REMARK 465 HIS A 491 REMARK 465 LEU A 492 REMARK 465 ARG A 493 REMARK 465 SER A 494 REMARK 465 ALA A 495 REMARK 465 GLY A 496 REMARK 465 SER A 497 REMARK 465 ARG A 498 REMARK 465 LEU A 499 REMARK 465 THR A 500 REMARK 465 LEU A 501 REMARK 465 SER A 502 REMARK 465 GLY A 503 REMARK 465 ARG A 504 REMARK 465 GLY A 505 REMARK 465 SER A 506 REMARK 465 ASN A 507 REMARK 465 TYR A 508 REMARK 465 GLY A 509 REMARK 465 SER A 510 REMARK 465 LEU A 511 REMARK 465 LEU A 512 REMARK 465 THR A 513 REMARK 465 THR A 514 REMARK 465 GLU A 515 REMARK 465 GLY A 516 REMARK 465 GLN A 517 REMARK 465 PHE A 518 REMARK 465 GLN A 519 REMARK 465 VAL A 520 REMARK 465 PHE A 521 REMARK 465 ALA A 522 REMARK 465 LYS A 523 REMARK 465 THR A 524 REMARK 465 ALA A 525 REMARK 465 TYR A 526 REMARK 465 TYR A 527 REMARK 465 LYS A 528 REMARK 465 GLY A 529 REMARK 465 ASN A 530 REMARK 465 LEU A 531 REMARK 465 VAL A 532 REMARK 465 ALA A 533 REMARK 465 VAL A 534 REMARK 465 LYS A 535 REMARK 465 ARG A 536 REMARK 465 VAL A 537 REMARK 465 ASN A 538 REMARK 465 ARG A 539 REMARK 465 LYS A 540 REMARK 465 ARG A 541 REMARK 465 ILE A 542 REMARK 465 GLU A 543 REMARK 465 LEU A 544 REMARK 465 THR A 545 REMARK 465 ARG A 546 REMARK 465 LYS A 547 REMARK 465 VAL A 548 REMARK 465 LEU A 549 REMARK 465 PHE A 550 REMARK 465 GLU A 551 REMARK 465 LEU A 552 REMARK 465 LYS A 553 REMARK 465 HIS A 554 REMARK 465 MET A 555 REMARK 465 ARG A 556 REMARK 465 ASP A 557 REMARK 465 VAL A 558 REMARK 465 GLN A 559 REMARK 465 ASN A 560 REMARK 465 GLU A 561 REMARK 465 HIS A 562 REMARK 465 LEU A 563 REMARK 465 THR A 564 REMARK 465 ARG A 565 REMARK 465 PHE A 566 REMARK 465 VAL A 567 REMARK 465 GLY A 568 REMARK 465 ALA A 569 REMARK 465 CYS A 570 REMARK 465 THR A 571 REMARK 465 ASP A 572 REMARK 465 PRO A 573 REMARK 465 PRO A 574 REMARK 465 ASN A 575 REMARK 465 ILE A 576 REMARK 465 CYS A 577 REMARK 465 ILE A 578 REMARK 465 LEU A 579 REMARK 465 THR A 580 REMARK 465 GLU A 581 REMARK 465 TYR A 582 REMARK 465 CYS A 583 REMARK 465 PRO A 584 REMARK 465 ARG A 585 REMARK 465 GLY A 586 REMARK 465 SER A 587 REMARK 465 LEU A 588 REMARK 465 GLN A 589 REMARK 465 ASP A 590 REMARK 465 ILE A 591 REMARK 465 LEU A 592 REMARK 465 GLU A 593 REMARK 465 ASN A 594 REMARK 465 GLU A 595 REMARK 465 SER A 596 REMARK 465 ILE A 597 REMARK 465 THR A 598 REMARK 465 LEU A 599 REMARK 465 ASP A 600 REMARK 465 TRP A 601 REMARK 465 MET A 602 REMARK 465 PHE A 603 REMARK 465 ARG A 604 REMARK 465 TYR A 605 REMARK 465 SER A 606 REMARK 465 LEU A 607 REMARK 465 THR A 608 REMARK 465 ASN A 609 REMARK 465 ASP A 610 REMARK 465 ILE A 611 REMARK 465 VAL A 612 REMARK 465 LYS A 613 REMARK 465 GLY A 614 REMARK 465 MET A 615 REMARK 465 LEU A 616 REMARK 465 PHE A 617 REMARK 465 LEU A 618 REMARK 465 HIS A 619 REMARK 465 ASN A 620 REMARK 465 GLY A 621 REMARK 465 ALA A 622 REMARK 465 ILE A 623 REMARK 465 CYS A 624 REMARK 465 SER A 625 REMARK 465 HIS A 626 REMARK 465 GLY A 627 REMARK 465 ASN A 628 REMARK 465 LEU A 629 REMARK 465 LYS A 630 REMARK 465 SER A 631 REMARK 465 SER A 632 REMARK 465 ASN A 633 REMARK 465 CYS A 634 REMARK 465 VAL A 635 REMARK 465 VAL A 636 REMARK 465 ASP A 637 REMARK 465 GLY A 638 REMARK 465 ARG A 639 REMARK 465 PHE A 640 REMARK 465 VAL A 641 REMARK 465 LEU A 642 REMARK 465 LYS A 643 REMARK 465 ILE A 644 REMARK 465 THR A 645 REMARK 465 ASP A 646 REMARK 465 TYR A 647 REMARK 465 GLY A 648 REMARK 465 LEU A 649 REMARK 465 GLU A 650 REMARK 465 SER A 651 REMARK 465 PHE A 652 REMARK 465 ARG A 653 REMARK 465 ASP A 654 REMARK 465 LEU A 655 REMARK 465 ASP A 656 REMARK 465 PRO A 657 REMARK 465 GLU A 658 REMARK 465 GLN A 659 REMARK 465 GLY A 660 REMARK 465 HIS A 661 REMARK 465 THR A 662 REMARK 465 VAL A 663 REMARK 465 TYR A 664 REMARK 465 ALA A 665 REMARK 465 LYS A 666 REMARK 465 LYS A 667 REMARK 465 LEU A 668 REMARK 465 TRP A 669 REMARK 465 THR A 670 REMARK 465 ALA A 671 REMARK 465 PRO A 672 REMARK 465 GLU A 673 REMARK 465 LEU A 674 REMARK 465 LEU A 675 REMARK 465 ARG A 676 REMARK 465 MET A 677 REMARK 465 ALA A 678 REMARK 465 SER A 679 REMARK 465 PRO A 680 REMARK 465 PRO A 681 REMARK 465 VAL A 682 REMARK 465 ARG A 683 REMARK 465 GLY A 684 REMARK 465 SER A 685 REMARK 465 GLN A 686 REMARK 465 ALA A 687 REMARK 465 GLY A 688 REMARK 465 ASP A 689 REMARK 465 VAL A 690 REMARK 465 TYR A 691 REMARK 465 SER A 692 REMARK 465 PHE A 693 REMARK 465 GLY A 694 REMARK 465 ILE A 695 REMARK 465 ILE A 696 REMARK 465 LEU A 697 REMARK 465 GLN A 698 REMARK 465 GLU A 699 REMARK 465 ILE A 700 REMARK 465 ALA A 701 REMARK 465 LEU A 702 REMARK 465 ARG A 703 REMARK 465 SER A 704 REMARK 465 GLY A 705 REMARK 465 VAL A 706 REMARK 465 PHE A 707 REMARK 465 HIS A 708 REMARK 465 VAL A 709 REMARK 465 GLU A 710 REMARK 465 GLY A 711 REMARK 465 LEU A 712 REMARK 465 ASP A 713 REMARK 465 LEU A 714 REMARK 465 SER A 715 REMARK 465 PRO A 716 REMARK 465 LYS A 717 REMARK 465 GLU A 718 REMARK 465 ILE A 719 REMARK 465 ILE A 720 REMARK 465 GLU A 721 REMARK 465 ARG A 722 REMARK 465 VAL A 723 REMARK 465 THR A 724 REMARK 465 ARG A 725 REMARK 465 GLY A 726 REMARK 465 GLU A 727 REMARK 465 GLN A 728 REMARK 465 PRO A 729 REMARK 465 PRO A 730 REMARK 465 PHE A 731 REMARK 465 ARG A 732 REMARK 465 PRO A 733 REMARK 465 SER A 734 REMARK 465 LEU A 735 REMARK 465 ALA A 736 REMARK 465 LEU A 737 REMARK 465 GLN A 738 REMARK 465 SER A 739 REMARK 465 HIS A 740 REMARK 465 LEU A 741 REMARK 465 GLU A 742 REMARK 465 GLU A 743 REMARK 465 LEU A 744 REMARK 465 GLY A 745 REMARK 465 LEU A 746 REMARK 465 LEU A 747 REMARK 465 MET A 748 REMARK 465 GLN A 749 REMARK 465 ARG A 750 REMARK 465 CYS A 751 REMARK 465 TRP A 752 REMARK 465 ALA A 753 REMARK 465 GLU A 754 REMARK 465 ASP A 755 REMARK 465 PRO A 756 REMARK 465 GLN A 757 REMARK 465 GLU A 758 REMARK 465 ARG A 759 REMARK 465 PRO A 760 REMARK 465 PRO A 761 REMARK 465 PHE A 762 REMARK 465 GLN A 763 REMARK 465 GLN A 764 REMARK 465 ILE A 765 REMARK 465 ARG A 766 REMARK 465 LEU A 767 REMARK 465 THR A 768 REMARK 465 LEU A 769 REMARK 465 ARG A 770 REMARK 465 LYS A 771 REMARK 465 PHE A 772 REMARK 465 ASN A 773 REMARK 465 ARG A 774 REMARK 465 GLU A 775 REMARK 465 ASN A 776 REMARK 465 SER A 777 REMARK 465 SER A 778 REMARK 465 ASN A 779 REMARK 465 ILE A 780 REMARK 465 LEU A 781 REMARK 465 ASP A 782 REMARK 465 ASN A 783 REMARK 465 LEU A 784 REMARK 465 LEU A 785 REMARK 465 SER A 786 REMARK 465 ARG A 787 REMARK 465 MET A 788 REMARK 465 GLU A 789 REMARK 465 GLN A 790 REMARK 465 TYR A 791 REMARK 465 ALA A 792 REMARK 465 ASN A 793 REMARK 465 ASN A 794 REMARK 465 LEU A 795 REMARK 465 GLU A 796 REMARK 465 GLU A 797 REMARK 465 LEU A 798 REMARK 465 VAL A 799 REMARK 465 GLU A 800 REMARK 465 GLU A 801 REMARK 465 ARG A 802 REMARK 465 THR A 803 REMARK 465 GLN A 804 REMARK 465 ALA A 805 REMARK 465 TYR A 806 REMARK 465 LEU A 807 REMARK 465 GLU A 808 REMARK 465 GLU A 809 REMARK 465 LYS A 810 REMARK 465 ARG A 811 REMARK 465 LYS A 812 REMARK 465 ALA A 813 REMARK 465 GLU A 814 REMARK 465 ALA A 815 REMARK 465 LEU A 816 REMARK 465 LEU A 817 REMARK 465 TYR A 818 REMARK 465 GLN A 819 REMARK 465 ILE A 820 REMARK 465 LEU A 821 REMARK 465 PRO A 822 REMARK 465 HIS A 823 REMARK 465 SER A 824 REMARK 465 VAL A 825 REMARK 465 ALA A 826 REMARK 465 GLU A 827 REMARK 465 GLN A 828 REMARK 465 LEU A 829 REMARK 465 LYS A 830 REMARK 465 ARG A 831 REMARK 465 GLY A 832 REMARK 465 GLU A 833 REMARK 465 THR A 834 REMARK 465 VAL A 835 REMARK 465 GLN A 836 REMARK 465 ALA A 837 REMARK 465 GLU A 838 REMARK 465 ALA A 839 REMARK 465 PHE A 840 REMARK 465 ASP A 841 REMARK 465 SER A 842 REMARK 465 VAL A 843 REMARK 465 THR A 844 REMARK 465 ILE A 845 REMARK 465 TYR A 846 REMARK 465 PHE A 847 REMARK 465 SER A 848 REMARK 465 ASP A 849 REMARK 465 ILE A 850 REMARK 465 VAL A 851 REMARK 465 GLY A 852 REMARK 465 PHE A 853 REMARK 465 THR A 854 REMARK 465 ALA A 855 REMARK 465 LEU A 856 REMARK 465 SER A 857 REMARK 465 ALA A 858 REMARK 465 GLU A 859 REMARK 465 SER A 860 REMARK 465 THR A 861 REMARK 465 PRO A 862 REMARK 465 MET A 863 REMARK 465 GLN A 864 REMARK 465 VAL A 865 REMARK 465 VAL A 866 REMARK 465 THR A 867 REMARK 465 LEU A 868 REMARK 465 LEU A 869 REMARK 465 ASN A 870 REMARK 465 ASP A 871 REMARK 465 LEU A 872 REMARK 465 TYR A 873 REMARK 465 THR A 874 REMARK 465 CYS A 875 REMARK 465 PHE A 876 REMARK 465 ASP A 877 REMARK 465 ALA A 878 REMARK 465 VAL A 879 REMARK 465 ILE A 880 REMARK 465 ASP A 881 REMARK 465 ASN A 882 REMARK 465 PHE A 883 REMARK 465 ASP A 884 REMARK 465 VAL A 885 REMARK 465 TYR A 886 REMARK 465 LYS A 887 REMARK 465 VAL A 888 REMARK 465 GLU A 889 REMARK 465 THR A 890 REMARK 465 ILE A 891 REMARK 465 GLY A 892 REMARK 465 ASP A 893 REMARK 465 ALA A 894 REMARK 465 TYR A 895 REMARK 465 MET A 896 REMARK 465 VAL A 897 REMARK 465 VAL A 898 REMARK 465 SER A 899 REMARK 465 GLY A 900 REMARK 465 LEU A 901 REMARK 465 PRO A 902 REMARK 465 VAL A 903 REMARK 465 ARG A 904 REMARK 465 ASN A 905 REMARK 465 GLY A 906 REMARK 465 ARG A 907 REMARK 465 LEU A 908 REMARK 465 HIS A 909 REMARK 465 ALA A 910 REMARK 465 CYS A 911 REMARK 465 GLU A 912 REMARK 465 VAL A 913 REMARK 465 ALA A 914 REMARK 465 ARG A 915 REMARK 465 MET A 916 REMARK 465 ALA A 917 REMARK 465 LEU A 918 REMARK 465 ALA A 919 REMARK 465 LEU A 920 REMARK 465 LEU A 921 REMARK 465 ASP A 922 REMARK 465 ALA A 923 REMARK 465 VAL A 924 REMARK 465 ARG A 925 REMARK 465 SER A 926 REMARK 465 PHE A 927 REMARK 465 ARG A 928 REMARK 465 ILE A 929 REMARK 465 ARG A 930 REMARK 465 HIS A 931 REMARK 465 ARG A 932 REMARK 465 PRO A 933 REMARK 465 GLN A 934 REMARK 465 GLU A 935 REMARK 465 GLN A 936 REMARK 465 LEU A 937 REMARK 465 ARG A 938 REMARK 465 LEU A 939 REMARK 465 ARG A 940 REMARK 465 ILE A 941 REMARK 465 GLY A 942 REMARK 465 ILE A 943 REMARK 465 HIS A 944 REMARK 465 THR A 945 REMARK 465 GLY A 946 REMARK 465 PRO A 947 REMARK 465 VAL A 948 REMARK 465 CYS A 949 REMARK 465 ALA A 950 REMARK 465 GLY A 951 REMARK 465 VAL A 952 REMARK 465 VAL A 953 REMARK 465 GLY A 954 REMARK 465 LEU A 955 REMARK 465 LYS A 956 REMARK 465 MET A 957 REMARK 465 PRO A 958 REMARK 465 ARG A 959 REMARK 465 TYR A 960 REMARK 465 CYS A 961 REMARK 465 LEU A 962 REMARK 465 PHE A 963 REMARK 465 GLY A 964 REMARK 465 ASP A 965 REMARK 465 THR A 966 REMARK 465 VAL A 967 REMARK 465 ASN A 968 REMARK 465 THR A 969 REMARK 465 ALA A 970 REMARK 465 SER A 971 REMARK 465 ARG A 972 REMARK 465 MET A 973 REMARK 465 GLU A 974 REMARK 465 SER A 975 REMARK 465 ASN A 976 REMARK 465 GLY A 977 REMARK 465 GLU A 978 REMARK 465 ALA A 979 REMARK 465 LEU A 980 REMARK 465 LYS A 981 REMARK 465 ILE A 982 REMARK 465 HIS A 983 REMARK 465 LEU A 984 REMARK 465 SER A 985 REMARK 465 SER A 986 REMARK 465 GLU A 987 REMARK 465 THR A 988 REMARK 465 LYS A 989 REMARK 465 ALA A 990 REMARK 465 VAL A 991 REMARK 465 LEU A 992 REMARK 465 GLU A 993 REMARK 465 GLU A 994 REMARK 465 PHE A 995 REMARK 465 GLY A 996 REMARK 465 GLY A 997 REMARK 465 PHE A 998 REMARK 465 GLU A 999 REMARK 465 LEU A 1000 REMARK 465 GLU A 1001 REMARK 465 LEU A 1002 REMARK 465 ARG A 1003 REMARK 465 GLY A 1004 REMARK 465 ASP A 1005 REMARK 465 VAL A 1006 REMARK 465 GLU A 1007 REMARK 465 MET A 1008 REMARK 465 LYS A 1009 REMARK 465 GLY A 1010 REMARK 465 LYS A 1011 REMARK 465 GLY A 1012 REMARK 465 LYS A 1013 REMARK 465 VAL A 1014 REMARK 465 ARG A 1015 REMARK 465 THR A 1016 REMARK 465 TYR A 1017 REMARK 465 TRP A 1018 REMARK 465 LEU A 1019 REMARK 465 LEU A 1020 REMARK 465 GLY A 1021 REMARK 465 GLU A 1022 REMARK 465 ARG A 1023 REMARK 465 GLY A 1024 REMARK 465 SER A 1025 REMARK 465 SER A 1026 REMARK 465 THR A 1027 REMARK 465 ARG A 1028 REMARK 465 GLY A 1029 REMARK 465 ASP B 426 REMARK 465 ASN B 427 REMARK 465 GLU B 428 REMARK 465 ASP B 429 REMARK 465 PRO B 430 REMARK 465 ALA B 431 REMARK 465 CYS B 432 REMARK 465 ASN B 433 REMARK 465 GLN B 434 REMARK 465 ASP B 435 REMARK 465 HIS B 436 REMARK 465 LEU B 437 REMARK 465 SER B 438 REMARK 465 THR B 439 REMARK 465 LEU B 440 REMARK 465 GLU B 441 REMARK 465 VAL B 442 REMARK 465 LEU B 443 REMARK 465 ALA B 444 REMARK 465 LEU B 445 REMARK 465 VAL B 446 REMARK 465 GLY B 447 REMARK 465 SER B 448 REMARK 465 LEU B 449 REMARK 465 SER B 450 REMARK 465 LEU B 451 REMARK 465 LEU B 452 REMARK 465 GLY B 453 REMARK 465 ILE B 454 REMARK 465 LEU B 455 REMARK 465 ILE B 456 REMARK 465 VAL B 457 REMARK 465 SER B 458 REMARK 465 PHE B 459 REMARK 465 PHE B 460 REMARK 465 ILE B 461 REMARK 465 TYR B 462 REMARK 465 ARG B 463 REMARK 465 LYS B 464 REMARK 465 MET B 465 REMARK 465 GLN B 466 REMARK 465 LEU B 467 REMARK 465 GLU B 468 REMARK 465 LYS B 469 REMARK 465 GLU B 470 REMARK 465 LEU B 471 REMARK 465 ALA B 472 REMARK 465 SER B 473 REMARK 465 GLU B 474 REMARK 465 LEU B 475 REMARK 465 TRP B 476 REMARK 465 ARG B 477 REMARK 465 VAL B 478 REMARK 465 ARG B 479 REMARK 465 TRP B 480 REMARK 465 GLU B 481 REMARK 465 ASP B 482 REMARK 465 VAL B 483 REMARK 465 GLU B 484 REMARK 465 PRO B 485 REMARK 465 SER B 486 REMARK 465 SER B 487 REMARK 465 LEU B 488 REMARK 465 GLU B 489 REMARK 465 ARG B 490 REMARK 465 HIS B 491 REMARK 465 LEU B 492 REMARK 465 ARG B 493 REMARK 465 SER B 494 REMARK 465 ALA B 495 REMARK 465 GLY B 496 REMARK 465 SER B 497 REMARK 465 ARG B 498 REMARK 465 LEU B 499 REMARK 465 THR B 500 REMARK 465 LEU B 501 REMARK 465 SER B 502 REMARK 465 GLY B 503 REMARK 465 ARG B 504 REMARK 465 GLY B 505 REMARK 465 SER B 506 REMARK 465 ASN B 507 REMARK 465 TYR B 508 REMARK 465 GLY B 509 REMARK 465 SER B 510 REMARK 465 LEU B 511 REMARK 465 LEU B 512 REMARK 465 THR B 513 REMARK 465 THR B 514 REMARK 465 GLU B 515 REMARK 465 GLY B 516 REMARK 465 GLN B 517 REMARK 465 PHE B 518 REMARK 465 GLN B 519 REMARK 465 VAL B 520 REMARK 465 PHE B 521 REMARK 465 ALA B 522 REMARK 465 LYS B 523 REMARK 465 THR B 524 REMARK 465 ALA B 525 REMARK 465 TYR B 526 REMARK 465 TYR B 527 REMARK 465 LYS B 528 REMARK 465 GLY B 529 REMARK 465 ASN B 530 REMARK 465 LEU B 531 REMARK 465 VAL B 532 REMARK 465 ALA B 533 REMARK 465 VAL B 534 REMARK 465 LYS B 535 REMARK 465 ARG B 536 REMARK 465 VAL B 537 REMARK 465 ASN B 538 REMARK 465 ARG B 539 REMARK 465 LYS B 540 REMARK 465 ARG B 541 REMARK 465 ILE B 542 REMARK 465 GLU B 543 REMARK 465 LEU B 544 REMARK 465 THR B 545 REMARK 465 ARG B 546 REMARK 465 LYS B 547 REMARK 465 VAL B 548 REMARK 465 LEU B 549 REMARK 465 PHE B 550 REMARK 465 GLU B 551 REMARK 465 LEU B 552 REMARK 465 LYS B 553 REMARK 465 HIS B 554 REMARK 465 MET B 555 REMARK 465 ARG B 556 REMARK 465 ASP B 557 REMARK 465 VAL B 558 REMARK 465 GLN B 559 REMARK 465 ASN B 560 REMARK 465 GLU B 561 REMARK 465 HIS B 562 REMARK 465 LEU B 563 REMARK 465 THR B 564 REMARK 465 ARG B 565 REMARK 465 PHE B 566 REMARK 465 VAL B 567 REMARK 465 GLY B 568 REMARK 465 ALA B 569 REMARK 465 CYS B 570 REMARK 465 THR B 571 REMARK 465 ASP B 572 REMARK 465 PRO B 573 REMARK 465 PRO B 574 REMARK 465 ASN B 575 REMARK 465 ILE B 576 REMARK 465 CYS B 577 REMARK 465 ILE B 578 REMARK 465 LEU B 579 REMARK 465 THR B 580 REMARK 465 GLU B 581 REMARK 465 TYR B 582 REMARK 465 CYS B 583 REMARK 465 PRO B 584 REMARK 465 ARG B 585 REMARK 465 GLY B 586 REMARK 465 SER B 587 REMARK 465 LEU B 588 REMARK 465 GLN B 589 REMARK 465 ASP B 590 REMARK 465 ILE B 591 REMARK 465 LEU B 592 REMARK 465 GLU B 593 REMARK 465 ASN B 594 REMARK 465 GLU B 595 REMARK 465 SER B 596 REMARK 465 ILE B 597 REMARK 465 THR B 598 REMARK 465 LEU B 599 REMARK 465 ASP B 600 REMARK 465 TRP B 601 REMARK 465 MET B 602 REMARK 465 PHE B 603 REMARK 465 ARG B 604 REMARK 465 TYR B 605 REMARK 465 SER B 606 REMARK 465 LEU B 607 REMARK 465 THR B 608 REMARK 465 ASN B 609 REMARK 465 ASP B 610 REMARK 465 ILE B 611 REMARK 465 VAL B 612 REMARK 465 LYS B 613 REMARK 465 GLY B 614 REMARK 465 MET B 615 REMARK 465 LEU B 616 REMARK 465 PHE B 617 REMARK 465 LEU B 618 REMARK 465 HIS B 619 REMARK 465 ASN B 620 REMARK 465 GLY B 621 REMARK 465 ALA B 622 REMARK 465 ILE B 623 REMARK 465 CYS B 624 REMARK 465 SER B 625 REMARK 465 HIS B 626 REMARK 465 GLY B 627 REMARK 465 ASN B 628 REMARK 465 LEU B 629 REMARK 465 LYS B 630 REMARK 465 SER B 631 REMARK 465 SER B 632 REMARK 465 ASN B 633 REMARK 465 CYS B 634 REMARK 465 VAL B 635 REMARK 465 VAL B 636 REMARK 465 ASP B 637 REMARK 465 GLY B 638 REMARK 465 ARG B 639 REMARK 465 PHE B 640 REMARK 465 VAL B 641 REMARK 465 LEU B 642 REMARK 465 LYS B 643 REMARK 465 ILE B 644 REMARK 465 THR B 645 REMARK 465 ASP B 646 REMARK 465 TYR B 647 REMARK 465 GLY B 648 REMARK 465 LEU B 649 REMARK 465 GLU B 650 REMARK 465 SER B 651 REMARK 465 PHE B 652 REMARK 465 ARG B 653 REMARK 465 ASP B 654 REMARK 465 LEU B 655 REMARK 465 ASP B 656 REMARK 465 PRO B 657 REMARK 465 GLU B 658 REMARK 465 GLN B 659 REMARK 465 GLY B 660 REMARK 465 HIS B 661 REMARK 465 THR B 662 REMARK 465 VAL B 663 REMARK 465 TYR B 664 REMARK 465 ALA B 665 REMARK 465 LYS B 666 REMARK 465 LYS B 667 REMARK 465 LEU B 668 REMARK 465 TRP B 669 REMARK 465 THR B 670 REMARK 465 ALA B 671 REMARK 465 PRO B 672 REMARK 465 GLU B 673 REMARK 465 LEU B 674 REMARK 465 LEU B 675 REMARK 465 ARG B 676 REMARK 465 MET B 677 REMARK 465 ALA B 678 REMARK 465 SER B 679 REMARK 465 PRO B 680 REMARK 465 PRO B 681 REMARK 465 VAL B 682 REMARK 465 ARG B 683 REMARK 465 GLY B 684 REMARK 465 SER B 685 REMARK 465 GLN B 686 REMARK 465 ALA B 687 REMARK 465 GLY B 688 REMARK 465 ASP B 689 REMARK 465 VAL B 690 REMARK 465 TYR B 691 REMARK 465 SER B 692 REMARK 465 PHE B 693 REMARK 465 GLY B 694 REMARK 465 ILE B 695 REMARK 465 ILE B 696 REMARK 465 LEU B 697 REMARK 465 GLN B 698 REMARK 465 GLU B 699 REMARK 465 ILE B 700 REMARK 465 ALA B 701 REMARK 465 LEU B 702 REMARK 465 ARG B 703 REMARK 465 SER B 704 REMARK 465 GLY B 705 REMARK 465 VAL B 706 REMARK 465 PHE B 707 REMARK 465 HIS B 708 REMARK 465 VAL B 709 REMARK 465 GLU B 710 REMARK 465 GLY B 711 REMARK 465 LEU B 712 REMARK 465 ASP B 713 REMARK 465 LEU B 714 REMARK 465 SER B 715 REMARK 465 PRO B 716 REMARK 465 LYS B 717 REMARK 465 GLU B 718 REMARK 465 ILE B 719 REMARK 465 ILE B 720 REMARK 465 GLU B 721 REMARK 465 ARG B 722 REMARK 465 VAL B 723 REMARK 465 THR B 724 REMARK 465 ARG B 725 REMARK 465 GLY B 726 REMARK 465 GLU B 727 REMARK 465 GLN B 728 REMARK 465 PRO B 729 REMARK 465 PRO B 730 REMARK 465 PHE B 731 REMARK 465 ARG B 732 REMARK 465 PRO B 733 REMARK 465 SER B 734 REMARK 465 LEU B 735 REMARK 465 ALA B 736 REMARK 465 LEU B 737 REMARK 465 GLN B 738 REMARK 465 SER B 739 REMARK 465 HIS B 740 REMARK 465 LEU B 741 REMARK 465 GLU B 742 REMARK 465 GLU B 743 REMARK 465 LEU B 744 REMARK 465 GLY B 745 REMARK 465 LEU B 746 REMARK 465 LEU B 747 REMARK 465 MET B 748 REMARK 465 GLN B 749 REMARK 465 ARG B 750 REMARK 465 CYS B 751 REMARK 465 TRP B 752 REMARK 465 ALA B 753 REMARK 465 GLU B 754 REMARK 465 ASP B 755 REMARK 465 PRO B 756 REMARK 465 GLN B 757 REMARK 465 GLU B 758 REMARK 465 ARG B 759 REMARK 465 PRO B 760 REMARK 465 PRO B 761 REMARK 465 PHE B 762 REMARK 465 GLN B 763 REMARK 465 GLN B 764 REMARK 465 ILE B 765 REMARK 465 ARG B 766 REMARK 465 LEU B 767 REMARK 465 THR B 768 REMARK 465 LEU B 769 REMARK 465 ARG B 770 REMARK 465 LYS B 771 REMARK 465 PHE B 772 REMARK 465 ASN B 773 REMARK 465 ARG B 774 REMARK 465 GLU B 775 REMARK 465 ASN B 776 REMARK 465 SER B 777 REMARK 465 SER B 778 REMARK 465 ASN B 779 REMARK 465 ILE B 780 REMARK 465 LEU B 781 REMARK 465 ASP B 782 REMARK 465 ASN B 783 REMARK 465 LEU B 784 REMARK 465 LEU B 785 REMARK 465 SER B 786 REMARK 465 ARG B 787 REMARK 465 MET B 788 REMARK 465 GLU B 789 REMARK 465 GLN B 790 REMARK 465 TYR B 791 REMARK 465 ALA B 792 REMARK 465 ASN B 793 REMARK 465 ASN B 794 REMARK 465 LEU B 795 REMARK 465 GLU B 796 REMARK 465 GLU B 797 REMARK 465 LEU B 798 REMARK 465 VAL B 799 REMARK 465 GLU B 800 REMARK 465 GLU B 801 REMARK 465 ARG B 802 REMARK 465 THR B 803 REMARK 465 GLN B 804 REMARK 465 ALA B 805 REMARK 465 TYR B 806 REMARK 465 LEU B 807 REMARK 465 GLU B 808 REMARK 465 GLU B 809 REMARK 465 LYS B 810 REMARK 465 ARG B 811 REMARK 465 LYS B 812 REMARK 465 ALA B 813 REMARK 465 GLU B 814 REMARK 465 ALA B 815 REMARK 465 LEU B 816 REMARK 465 LEU B 817 REMARK 465 TYR B 818 REMARK 465 GLN B 819 REMARK 465 ILE B 820 REMARK 465 LEU B 821 REMARK 465 PRO B 822 REMARK 465 HIS B 823 REMARK 465 SER B 824 REMARK 465 VAL B 825 REMARK 465 ALA B 826 REMARK 465 GLU B 827 REMARK 465 GLN B 828 REMARK 465 LEU B 829 REMARK 465 LYS B 830 REMARK 465 ARG B 831 REMARK 465 GLY B 832 REMARK 465 GLU B 833 REMARK 465 THR B 834 REMARK 465 VAL B 835 REMARK 465 GLN B 836 REMARK 465 ALA B 837 REMARK 465 GLU B 838 REMARK 465 ALA B 839 REMARK 465 PHE B 840 REMARK 465 ASP B 841 REMARK 465 SER B 842 REMARK 465 VAL B 843 REMARK 465 THR B 844 REMARK 465 ILE B 845 REMARK 465 TYR B 846 REMARK 465 PHE B 847 REMARK 465 SER B 848 REMARK 465 ASP B 849 REMARK 465 ILE B 850 REMARK 465 VAL B 851 REMARK 465 GLY B 852 REMARK 465 PHE B 853 REMARK 465 THR B 854 REMARK 465 ALA B 855 REMARK 465 LEU B 856 REMARK 465 SER B 857 REMARK 465 ALA B 858 REMARK 465 GLU B 859 REMARK 465 SER B 860 REMARK 465 THR B 861 REMARK 465 PRO B 862 REMARK 465 MET B 863 REMARK 465 GLN B 864 REMARK 465 VAL B 865 REMARK 465 VAL B 866 REMARK 465 THR B 867 REMARK 465 LEU B 868 REMARK 465 LEU B 869 REMARK 465 ASN B 870 REMARK 465 ASP B 871 REMARK 465 LEU B 872 REMARK 465 TYR B 873 REMARK 465 THR B 874 REMARK 465 CYS B 875 REMARK 465 PHE B 876 REMARK 465 ASP B 877 REMARK 465 ALA B 878 REMARK 465 VAL B 879 REMARK 465 ILE B 880 REMARK 465 ASP B 881 REMARK 465 ASN B 882 REMARK 465 PHE B 883 REMARK 465 ASP B 884 REMARK 465 VAL B 885 REMARK 465 TYR B 886 REMARK 465 LYS B 887 REMARK 465 VAL B 888 REMARK 465 GLU B 889 REMARK 465 THR B 890 REMARK 465 ILE B 891 REMARK 465 GLY B 892 REMARK 465 ASP B 893 REMARK 465 ALA B 894 REMARK 465 TYR B 895 REMARK 465 MET B 896 REMARK 465 VAL B 897 REMARK 465 VAL B 898 REMARK 465 SER B 899 REMARK 465 GLY B 900 REMARK 465 LEU B 901 REMARK 465 PRO B 902 REMARK 465 VAL B 903 REMARK 465 ARG B 904 REMARK 465 ASN B 905 REMARK 465 GLY B 906 REMARK 465 ARG B 907 REMARK 465 LEU B 908 REMARK 465 HIS B 909 REMARK 465 ALA B 910 REMARK 465 CYS B 911 REMARK 465 GLU B 912 REMARK 465 VAL B 913 REMARK 465 ALA B 914 REMARK 465 ARG B 915 REMARK 465 MET B 916 REMARK 465 ALA B 917 REMARK 465 LEU B 918 REMARK 465 ALA B 919 REMARK 465 LEU B 920 REMARK 465 LEU B 921 REMARK 465 ASP B 922 REMARK 465 ALA B 923 REMARK 465 VAL B 924 REMARK 465 ARG B 925 REMARK 465 SER B 926 REMARK 465 PHE B 927 REMARK 465 ARG B 928 REMARK 465 ILE B 929 REMARK 465 ARG B 930 REMARK 465 HIS B 931 REMARK 465 ARG B 932 REMARK 465 PRO B 933 REMARK 465 GLN B 934 REMARK 465 GLU B 935 REMARK 465 GLN B 936 REMARK 465 LEU B 937 REMARK 465 ARG B 938 REMARK 465 LEU B 939 REMARK 465 ARG B 940 REMARK 465 ILE B 941 REMARK 465 GLY B 942 REMARK 465 ILE B 943 REMARK 465 HIS B 944 REMARK 465 THR B 945 REMARK 465 GLY B 946 REMARK 465 PRO B 947 REMARK 465 VAL B 948 REMARK 465 CYS B 949 REMARK 465 ALA B 950 REMARK 465 GLY B 951 REMARK 465 VAL B 952 REMARK 465 VAL B 953 REMARK 465 GLY B 954 REMARK 465 LEU B 955 REMARK 465 LYS B 956 REMARK 465 MET B 957 REMARK 465 PRO B 958 REMARK 465 ARG B 959 REMARK 465 TYR B 960 REMARK 465 CYS B 961 REMARK 465 LEU B 962 REMARK 465 PHE B 963 REMARK 465 GLY B 964 REMARK 465 ASP B 965 REMARK 465 THR B 966 REMARK 465 VAL B 967 REMARK 465 ASN B 968 REMARK 465 THR B 969 REMARK 465 ALA B 970 REMARK 465 SER B 971 REMARK 465 ARG B 972 REMARK 465 MET B 973 REMARK 465 GLU B 974 REMARK 465 SER B 975 REMARK 465 ASN B 976 REMARK 465 GLY B 977 REMARK 465 GLU B 978 REMARK 465 ALA B 979 REMARK 465 LEU B 980 REMARK 465 LYS B 981 REMARK 465 ILE B 982 REMARK 465 HIS B 983 REMARK 465 LEU B 984 REMARK 465 SER B 985 REMARK 465 SER B 986 REMARK 465 GLU B 987 REMARK 465 THR B 988 REMARK 465 LYS B 989 REMARK 465 ALA B 990 REMARK 465 VAL B 991 REMARK 465 LEU B 992 REMARK 465 GLU B 993 REMARK 465 GLU B 994 REMARK 465 PHE B 995 REMARK 465 GLY B 996 REMARK 465 GLY B 997 REMARK 465 PHE B 998 REMARK 465 GLU B 999 REMARK 465 LEU B 1000 REMARK 465 GLU B 1001 REMARK 465 LEU B 1002 REMARK 465 ARG B 1003 REMARK 465 GLY B 1004 REMARK 465 ASP B 1005 REMARK 465 VAL B 1006 REMARK 465 GLU B 1007 REMARK 465 MET B 1008 REMARK 465 LYS B 1009 REMARK 465 GLY B 1010 REMARK 465 LYS B 1011 REMARK 465 GLY B 1012 REMARK 465 LYS B 1013 REMARK 465 VAL B 1014 REMARK 465 ARG B 1015 REMARK 465 THR B 1016 REMARK 465 TYR B 1017 REMARK 465 TRP B 1018 REMARK 465 LEU B 1019 REMARK 465 LEU B 1020 REMARK 465 GLY B 1021 REMARK 465 GLU B 1022 REMARK 465 ARG B 1023 REMARK 465 GLY B 1024 REMARK 465 SER B 1025 REMARK 465 SER B 1026 REMARK 465 THR B 1027 REMARK 465 ARG B 1028 REMARK 465 GLY B 1029 REMARK 465 SER C 1 REMARK 465 LEU C 2 REMARK 465 ARG C 3 REMARK 465 ARG C 4 REMARK 465 SER C 5 REMARK 465 SER C 6 REMARK 465 ARG C 27 REMARK 465 TYR C 28 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 GLN H 1 CG CD OE1 NE2 REMARK 470 GLU H 10 CG CD OE1 OE2 REMARK 470 SER H 17 OG REMARK 470 THR H 19 OG1 CG2 REMARK 470 SER H 25 OG REMARK 470 GLN H 62 CG CD OE1 NE2 REMARK 470 THR H 69 OG1 CG2 REMARK 470 THR H 71 OG1 CG2 REMARK 470 ASP H 73 CG OD1 OD2 REMARK 470 THR H 74 OG1 CG2 REMARK 470 SER H 75 OG REMARK 470 SER H 88 OG REMARK 470 ASP H 89 CG OD1 OD2 REMARK 470 MET H 103 CG SD CE REMARK 470 ASP H 112 CG OD1 OD2 REMARK 470 SER H 123 OG REMARK 470 SER H 124 OG REMARK 470 ASN L 1 CG OD1 ND2 REMARK 470 GLN L 3 CG CD OE1 NE2 REMARK 470 SER L 7 OG REMARK 470 SER L 9 OG REMARK 470 SER L 10 OG REMARK 470 SER L 12 OG REMARK 470 SER L 14 OG REMARK 470 ASP L 17 CG OD1 OD2 REMARK 470 THR L 20 OG1 CG2 REMARK 470 ASP L 30 CG OD1 OD2 REMARK 470 LYS L 42 CG CD CE NZ REMARK 470 SER L 52 OG REMARK 470 SER L 53 OG REMARK 470 SER L 56 OG REMARK 470 SER L 60 OG REMARK 470 SER L 63 OG REMARK 470 SER L 67 OG REMARK 470 SER L 77 OG REMARK 470 GLU L 81 CG CD OE1 OE2 REMARK 470 SER L 91 OG REMARK 470 SER L 93 OG REMARK 470 ILE L 94 CG1 CG2 CD1 REMARK 470 THR L 96 OG1 CG2 REMARK 470 GLN L 99 CG CD OE1 NE2 REMARK 470 GLU L 104 CG CD OE1 OE2 REMARK 470 GLN G 1 CG CD OE1 NE2 REMARK 470 GLU G 10 CG CD OE1 OE2 REMARK 470 SER G 17 OG REMARK 470 THR G 19 OG1 CG2 REMARK 470 SER G 25 OG REMARK 470 GLN G 62 CG CD OE1 NE2 REMARK 470 THR G 69 OG1 CG2 REMARK 470 ASP G 73 CG OD1 OD2 REMARK 470 THR G 74 OG1 CG2 REMARK 470 SER G 75 OG REMARK 470 SER G 88 OG REMARK 470 ASP G 89 CG OD1 OD2 REMARK 470 MET G 103 CG SD CE REMARK 470 ASP G 112 CG OD1 OD2 REMARK 470 SER G 123 OG REMARK 470 SER G 124 OG REMARK 470 ASN K 1 CG OD1 ND2 REMARK 470 GLN K 3 CG CD OE1 NE2 REMARK 470 SER K 7 OG REMARK 470 SER K 9 OG REMARK 470 SER K 10 OG REMARK 470 SER K 12 OG REMARK 470 SER K 14 OG REMARK 470 ASP K 17 CG OD1 OD2 REMARK 470 THR K 20 OG1 CG2 REMARK 470 ASP K 30 CG OD1 OD2 REMARK 470 LYS K 42 CG CD CE NZ REMARK 470 SER K 52 OG REMARK 470 SER K 53 OG REMARK 470 SER K 56 OG REMARK 470 SER K 60 OG REMARK 470 SER K 63 OG REMARK 470 SER K 65 OG REMARK 470 SER K 67 OG REMARK 470 THR K 74 OG1 CG2 REMARK 470 SER K 77 OG REMARK 470 GLU K 81 CG CD OE1 OE2 REMARK 470 SER K 91 OG REMARK 470 SER K 93 OG REMARK 470 ILE K 94 CG1 CG2 CD1 REMARK 470 THR K 96 OG1 CG2 REMARK 470 GLN K 99 CG CD OE1 NE2 REMARK 470 GLU K 104 CG CD OE1 OE2 REMARK 470 ASP A 39 CG OD1 OD2 REMARK 470 ASP A 62 CG OD1 OD2 REMARK 470 ASP A 71 CG OD1 OD2 REMARK 470 GLU A 75 CG CD OE1 OE2 REMARK 470 ASP A 118 CG OD1 OD2 REMARK 470 GLU A 119 CG CD OE1 OE2 REMARK 470 GLU A 147 CG CD OE1 OE2 REMARK 470 ARG A 148 CG CD NE CZ NH1 NH2 REMARK 470 ARG A 157 CG CD NE CZ NH1 NH2 REMARK 470 ASP A 160 CG OD1 OD2 REMARK 470 GLU A 161 CG CD OE1 OE2 REMARK 470 GLU A 162 CG CD OE1 OE2 REMARK 470 ASP A 177 CG OD1 OD2 REMARK 470 ASN A 180 CG OD1 ND2 REMARK 470 ASP A 184 CG OD1 OD2 REMARK 470 ASP A 191 CG OD1 OD2 REMARK 470 ASP A 192 CG OD1 OD2 REMARK 470 LEU A 193 CG CD1 CD2 REMARK 470 ARG A 205 CG CD NE CZ NH1 NH2 REMARK 470 ASP A 217 CG OD1 OD2 REMARK 470 GLU A 228 CG CD OE1 OE2 REMARK 470 ASP A 235 CG OD1 OD2 REMARK 470 ASP A 264 CG OD1 OD2 REMARK 470 VAL A 268 CG1 CG2 REMARK 470 ASP A 286 CG OD1 OD2 REMARK 470 GLU A 289 CG CD OE1 OE2 REMARK 470 GLU A 292 CG CD OE1 OE2 REMARK 470 LYS A 295 CG CD CE NZ REMARK 470 GLU A 303 CG CD OE1 OE2 REMARK 470 ASN A 306 CG OD1 ND2 REMARK 470 GLU A 310 CG CD OE1 OE2 REMARK 470 ASP A 311 CG OD1 OD2 REMARK 470 ASP A 344 CG OD1 OD2 REMARK 470 GLU A 346 CG CD OE1 OE2 REMARK 470 SER A 368 OG REMARK 470 SER A 369 OG REMARK 470 ASP A 380 CG OD1 OD2 REMARK 470 ASP A 382 CG OD1 OD2 REMARK 470 GLU A 384 CG CD OE1 OE2 REMARK 470 GLU A 400 CG CD OE1 OE2 REMARK 470 SER A 405 OG REMARK 470 LYS A 408 CG CD CE NZ REMARK 470 ASN A 410 CG OD1 ND2 REMARK 470 LYS A 422 CG CD CE NZ REMARK 470 CYS A 423 SG REMARK 470 ASP B 39 CG OD1 OD2 REMARK 470 ASP B 62 CG OD1 OD2 REMARK 470 ASP B 71 CG OD1 OD2 REMARK 470 GLU B 75 CG CD OE1 OE2 REMARK 470 ASP B 118 CG OD1 OD2 REMARK 470 GLU B 119 CG CD OE1 OE2 REMARK 470 GLU B 147 CG CD OE1 OE2 REMARK 470 ARG B 148 CG CD NE CZ NH1 NH2 REMARK 470 ARG B 157 CG CD NE CZ NH1 NH2 REMARK 470 ASP B 160 CG OD1 OD2 REMARK 470 GLU B 161 CG CD OE1 OE2 REMARK 470 GLU B 162 CG CD OE1 OE2 REMARK 470 ASP B 177 CG OD1 OD2 REMARK 470 ASN B 180 CG OD1 ND2 REMARK 470 ASP B 184 CG OD1 OD2 REMARK 470 ASP B 191 CG OD1 OD2 REMARK 470 ASP B 192 CG OD1 OD2 REMARK 470 LEU B 193 CG CD1 CD2 REMARK 470 ARG B 205 CG CD NE CZ NH1 NH2 REMARK 470 ASP B 217 CG OD1 OD2 REMARK 470 GLU B 228 CG CD OE1 OE2 REMARK 470 ASP B 235 CG OD1 OD2 REMARK 470 ASP B 264 CG OD1 OD2 REMARK 470 VAL B 268 CG1 CG2 REMARK 470 ASP B 286 CG OD1 OD2 REMARK 470 GLU B 289 CG CD OE1 OE2 REMARK 470 GLU B 292 CG CD OE1 OE2 REMARK 470 LYS B 295 CG CD CE NZ REMARK 470 GLU B 303 CG CD OE1 OE2 REMARK 470 ASN B 306 CG OD1 ND2 REMARK 470 GLU B 310 CG CD OE1 OE2 REMARK 470 ASP B 311 CG OD1 OD2 REMARK 470 ASP B 344 CG OD1 OD2 REMARK 470 GLU B 346 CG CD OE1 OE2 REMARK 470 SER B 368 OG REMARK 470 SER B 369 OG REMARK 470 ASP B 380 CG OD1 OD2 REMARK 470 ASP B 382 CG OD1 OD2 REMARK 470 GLU B 384 CG CD OE1 OE2 REMARK 470 GLU B 400 CG CD OE1 OE2 REMARK 470 SER B 405 OG REMARK 470 LYS B 408 CG CD CE NZ REMARK 470 ASN B 410 CG OD1 ND2 REMARK 470 ILE B 420 CG1 CG2 CD1 REMARK 470 LYS B 422 CG CD CE NZ REMARK 470 CYS B 423 SG REMARK 470 ASP C 13 CG OD1 OD2 REMARK 470 GLN C 18 CG CD OE1 NE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 O ASN B 13 OG SER B 19 2.10 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 VAL B 70 CG1 - CB - CG2 ANGL. DEV. = 11.3 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER L 9 -117.21 62.61 REMARK 500 PRO L 44 171.33 -57.36 REMARK 500 ALA L 51 -9.23 74.15 REMARK 500 SER L 52 -25.09 -140.51 REMARK 500 ASP L 82 30.16 -141.01 REMARK 500 SER K 9 -115.89 63.63 REMARK 500 PRO K 44 171.28 -57.48 REMARK 500 ALA K 51 -11.15 75.56 REMARK 500 ASP K 82 30.98 -140.97 REMARK 500 SER A 214 -179.70 -173.51 REMARK 500 THR A 343 50.90 -91.23 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 9DZF RELATED DB: PDB REMARK 900 RELATED ID: 9DZG RELATED DB: PDB REMARK 900 RELATED ID: 9DZH RELATED DB: PDB REMARK 900 RELATED ID: EMD-47331 RELATED DB: EMDB REMARK 900 HUMAN NPR1 BOUND TO ANP AND 2XRGN5308 DBREF 9DZJ H 1 227 PDB 9DZJ 9DZJ 1 227 DBREF 9DZJ L 1 213 PDB 9DZJ 9DZJ 1 213 DBREF 9DZJ G 1 227 PDB 9DZJ 9DZJ 1 227 DBREF 9DZJ K 1 213 PDB 9DZJ 9DZJ 1 213 DBREF 9DZJ A 0 1029 UNP P16066 ANPRA_HUMAN 32 1061 DBREF 9DZJ B 0 1029 UNP P16066 ANPRA_HUMAN 32 1061 DBREF 9DZJ C 1 28 UNP P01160 ANF_HUMAN 124 151 SEQADV 9DZJ ALA A -1 UNP P16066 EXPRESSION TAG SEQADV 9DZJ ALA B -1 UNP P16066 EXPRESSION TAG SEQRES 1 H 227 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 227 PRO GLY ALA SER VAL THR VAL SER CYS LYS ALA SER GLY SEQRES 3 H 227 TYR THR PHE THR ASP TYR TYR MET HIS TRP VAL ARG GLN SEQRES 4 H 227 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE LYS SEQRES 5 H 227 PRO ASN SER GLY GLY THR ASN SER ALA GLN ARG PHE GLN SEQRES 6 H 227 GLY ARG ILE THR MET THR TRP ASP THR SER ILE SER THR SEQRES 7 H 227 ALA TYR MET GLU LEU SER ARG LEU ARG SER ASP ASP THR SEQRES 8 H 227 ALA VAL TYR TYR CYS SER ARG GLY GLY PRO VAL MET ASN SEQRES 9 H 227 TYR TYR TYR TYR TYR GLY MET ASP VAL TRP GLY GLN GLY SEQRES 10 H 227 THR THR VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 H 227 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 H 227 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 H 227 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 H 227 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 H 227 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 H 227 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 H 227 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG SEQRES 18 H 227 VAL GLU PRO LYS SER CYS SEQRES 1 L 213 ASN ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 213 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 213 GLN SER ILE ASP SER TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 L 213 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR VAL ALA SER SEQRES 5 L 213 SER LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 213 GLY SER GLY LYS ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 213 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 L 213 TYR SER ILE PRO THR PHE GLY GLN GLY THR ARG LEU GLU SEQRES 9 L 213 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 L 213 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 L 213 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 L 213 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 L 213 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 L 213 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 L 213 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 L 213 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 L 213 ASN ARG GLY GLU CYS SEQRES 1 G 227 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 G 227 PRO GLY ALA SER VAL THR VAL SER CYS LYS ALA SER GLY SEQRES 3 G 227 TYR THR PHE THR ASP TYR TYR MET HIS TRP VAL ARG GLN SEQRES 4 G 227 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE LYS SEQRES 5 G 227 PRO ASN SER GLY GLY THR ASN SER ALA GLN ARG PHE GLN SEQRES 6 G 227 GLY ARG ILE THR MET THR TRP ASP THR SER ILE SER THR SEQRES 7 G 227 ALA TYR MET GLU LEU SER ARG LEU ARG SER ASP ASP THR SEQRES 8 G 227 ALA VAL TYR TYR CYS SER ARG GLY GLY PRO VAL MET ASN SEQRES 9 G 227 TYR TYR TYR TYR TYR GLY MET ASP VAL TRP GLY GLN GLY SEQRES 10 G 227 THR THR VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 G 227 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 G 227 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 G 227 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 G 227 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 G 227 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 G 227 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 G 227 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG SEQRES 18 G 227 VAL GLU PRO LYS SER CYS SEQRES 1 K 213 ASN ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 K 213 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 K 213 GLN SER ILE ASP SER TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 K 213 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR VAL ALA SER SEQRES 5 K 213 SER LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 K 213 GLY SER GLY LYS ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 K 213 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 K 213 TYR SER ILE PRO THR PHE GLY GLN GLY THR ARG LEU GLU SEQRES 9 K 213 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 K 213 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 K 213 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 K 213 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 K 213 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 K 213 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 K 213 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 K 213 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 K 213 ASN ARG GLY GLU CYS SEQRES 1 A 1031 ALA ALA GLY ASN LEU THR VAL ALA VAL VAL LEU PRO LEU SEQRES 2 A 1031 ALA ASN THR SER TYR PRO TRP SER TRP ALA ARG VAL GLY SEQRES 3 A 1031 PRO ALA VAL GLU LEU ALA LEU ALA GLN VAL LYS ALA ARG SEQRES 4 A 1031 PRO ASP LEU LEU PRO GLY TRP THR VAL ARG THR VAL LEU SEQRES 5 A 1031 GLY SER SER GLU ASN ALA LEU GLY VAL CYS SER ASP THR SEQRES 6 A 1031 ALA ALA PRO LEU ALA ALA VAL ASP LEU LYS TRP GLU HIS SEQRES 7 A 1031 ASN PRO ALA VAL PHE LEU GLY PRO GLY CYS VAL TYR ALA SEQRES 8 A 1031 ALA ALA PRO VAL GLY ARG PHE THR ALA HIS TRP ARG VAL SEQRES 9 A 1031 PRO LEU LEU THR ALA GLY ALA PRO ALA LEU GLY PHE GLY SEQRES 10 A 1031 VAL LYS ASP GLU TYR ALA LEU THR THR ARG ALA GLY PRO SEQRES 11 A 1031 SER TYR ALA LYS LEU GLY ASP PHE VAL ALA ALA LEU HIS SEQRES 12 A 1031 ARG ARG LEU GLY TRP GLU ARG GLN ALA LEU MET LEU TYR SEQRES 13 A 1031 ALA TYR ARG PRO GLY ASP GLU GLU HIS CYS PHE PHE LEU SEQRES 14 A 1031 VAL GLU GLY LEU PHE MET ARG VAL ARG ASP ARG LEU ASN SEQRES 15 A 1031 ILE THR VAL ASP HIS LEU GLU PHE ALA GLU ASP ASP LEU SEQRES 16 A 1031 SER HIS TYR THR ARG LEU LEU ARG THR MET PRO ARG LYS SEQRES 17 A 1031 GLY ARG VAL ILE TYR ILE CYS SER SER PRO ASP ALA PHE SEQRES 18 A 1031 ARG THR LEU MET LEU LEU ALA LEU GLU ALA GLY LEU CYS SEQRES 19 A 1031 GLY GLU ASP TYR VAL PHE PHE HIS LEU ASP ILE PHE GLY SEQRES 20 A 1031 GLN SER LEU GLN GLY GLY GLN GLY PRO ALA PRO ARG ARG SEQRES 21 A 1031 PRO TRP GLU ARG GLY ASP GLY GLN ASP VAL SER ALA ARG SEQRES 22 A 1031 GLN ALA PHE GLN ALA ALA LYS ILE ILE THR TYR LYS ASP SEQRES 23 A 1031 PRO ASP ASN PRO GLU TYR LEU GLU PHE LEU LYS GLN LEU SEQRES 24 A 1031 LYS HIS LEU ALA TYR GLU GLN PHE ASN PHE THR MET GLU SEQRES 25 A 1031 ASP GLY LEU VAL ASN THR ILE PRO ALA SER PHE HIS ASP SEQRES 26 A 1031 GLY LEU LEU LEU TYR ILE GLN ALA VAL THR GLU THR LEU SEQRES 27 A 1031 ALA HIS GLY GLY THR VAL THR ASP GLY GLU ASN ILE THR SEQRES 28 A 1031 GLN ARG MET TRP ASN ARG SER PHE GLN GLY VAL THR GLY SEQRES 29 A 1031 TYR LEU LYS ILE ASP SER SER GLY ASP ARG GLU THR ASP SEQRES 30 A 1031 PHE SER LEU TRP ASP MET ASP PRO GLU ASN GLY ALA PHE SEQRES 31 A 1031 ARG VAL VAL LEU ASN TYR ASN GLY THR SER GLN GLU LEU SEQRES 32 A 1031 VAL ALA VAL SER GLY ARG LYS LEU ASN TRP PRO LEU GLY SEQRES 33 A 1031 TYR PRO PRO PRO ASP ILE PRO LYS CYS GLY PHE ASP ASN SEQRES 34 A 1031 GLU ASP PRO ALA CYS ASN GLN ASP HIS LEU SER THR LEU SEQRES 35 A 1031 GLU VAL LEU ALA LEU VAL GLY SER LEU SER LEU LEU GLY SEQRES 36 A 1031 ILE LEU ILE VAL SER PHE PHE ILE TYR ARG LYS MET GLN SEQRES 37 A 1031 LEU GLU LYS GLU LEU ALA SER GLU LEU TRP ARG VAL ARG SEQRES 38 A 1031 TRP GLU ASP VAL GLU PRO SER SER LEU GLU ARG HIS LEU SEQRES 39 A 1031 ARG SER ALA GLY SER ARG LEU THR LEU SER GLY ARG GLY SEQRES 40 A 1031 SER ASN TYR GLY SER LEU LEU THR THR GLU GLY GLN PHE SEQRES 41 A 1031 GLN VAL PHE ALA LYS THR ALA TYR TYR LYS GLY ASN LEU SEQRES 42 A 1031 VAL ALA VAL LYS ARG VAL ASN ARG LYS ARG ILE GLU LEU SEQRES 43 A 1031 THR ARG LYS VAL LEU PHE GLU LEU LYS HIS MET ARG ASP SEQRES 44 A 1031 VAL GLN ASN GLU HIS LEU THR ARG PHE VAL GLY ALA CYS SEQRES 45 A 1031 THR ASP PRO PRO ASN ILE CYS ILE LEU THR GLU TYR CYS SEQRES 46 A 1031 PRO ARG GLY SER LEU GLN ASP ILE LEU GLU ASN GLU SER SEQRES 47 A 1031 ILE THR LEU ASP TRP MET PHE ARG TYR SER LEU THR ASN SEQRES 48 A 1031 ASP ILE VAL LYS GLY MET LEU PHE LEU HIS ASN GLY ALA SEQRES 49 A 1031 ILE CYS SER HIS GLY ASN LEU LYS SER SER ASN CYS VAL SEQRES 50 A 1031 VAL ASP GLY ARG PHE VAL LEU LYS ILE THR ASP TYR GLY SEQRES 51 A 1031 LEU GLU SER PHE ARG ASP LEU ASP PRO GLU GLN GLY HIS SEQRES 52 A 1031 THR VAL TYR ALA LYS LYS LEU TRP THR ALA PRO GLU LEU SEQRES 53 A 1031 LEU ARG MET ALA SER PRO PRO VAL ARG GLY SER GLN ALA SEQRES 54 A 1031 GLY ASP VAL TYR SER PHE GLY ILE ILE LEU GLN GLU ILE SEQRES 55 A 1031 ALA LEU ARG SER GLY VAL PHE HIS VAL GLU GLY LEU ASP SEQRES 56 A 1031 LEU SER PRO LYS GLU ILE ILE GLU ARG VAL THR ARG GLY SEQRES 57 A 1031 GLU GLN PRO PRO PHE ARG PRO SER LEU ALA LEU GLN SER SEQRES 58 A 1031 HIS LEU GLU GLU LEU GLY LEU LEU MET GLN ARG CYS TRP SEQRES 59 A 1031 ALA GLU ASP PRO GLN GLU ARG PRO PRO PHE GLN GLN ILE SEQRES 60 A 1031 ARG LEU THR LEU ARG LYS PHE ASN ARG GLU ASN SER SER SEQRES 61 A 1031 ASN ILE LEU ASP ASN LEU LEU SER ARG MET GLU GLN TYR SEQRES 62 A 1031 ALA ASN ASN LEU GLU GLU LEU VAL GLU GLU ARG THR GLN SEQRES 63 A 1031 ALA TYR LEU GLU GLU LYS ARG LYS ALA GLU ALA LEU LEU SEQRES 64 A 1031 TYR GLN ILE LEU PRO HIS SER VAL ALA GLU GLN LEU LYS SEQRES 65 A 1031 ARG GLY GLU THR VAL GLN ALA GLU ALA PHE ASP SER VAL SEQRES 66 A 1031 THR ILE TYR PHE SER ASP ILE VAL GLY PHE THR ALA LEU SEQRES 67 A 1031 SER ALA GLU SER THR PRO MET GLN VAL VAL THR LEU LEU SEQRES 68 A 1031 ASN ASP LEU TYR THR CYS PHE ASP ALA VAL ILE ASP ASN SEQRES 69 A 1031 PHE ASP VAL TYR LYS VAL GLU THR ILE GLY ASP ALA TYR SEQRES 70 A 1031 MET VAL VAL SER GLY LEU PRO VAL ARG ASN GLY ARG LEU SEQRES 71 A 1031 HIS ALA CYS GLU VAL ALA ARG MET ALA LEU ALA LEU LEU SEQRES 72 A 1031 ASP ALA VAL ARG SER PHE ARG ILE ARG HIS ARG PRO GLN SEQRES 73 A 1031 GLU GLN LEU ARG LEU ARG ILE GLY ILE HIS THR GLY PRO SEQRES 74 A 1031 VAL CYS ALA GLY VAL VAL GLY LEU LYS MET PRO ARG TYR SEQRES 75 A 1031 CYS LEU PHE GLY ASP THR VAL ASN THR ALA SER ARG MET SEQRES 76 A 1031 GLU SER ASN GLY GLU ALA LEU LYS ILE HIS LEU SER SER SEQRES 77 A 1031 GLU THR LYS ALA VAL LEU GLU GLU PHE GLY GLY PHE GLU SEQRES 78 A 1031 LEU GLU LEU ARG GLY ASP VAL GLU MET LYS GLY LYS GLY SEQRES 79 A 1031 LYS VAL ARG THR TYR TRP LEU LEU GLY GLU ARG GLY SER SEQRES 80 A 1031 SER THR ARG GLY SEQRES 1 B 1031 ALA ALA GLY ASN LEU THR VAL ALA VAL VAL LEU PRO LEU SEQRES 2 B 1031 ALA ASN THR SER TYR PRO TRP SER TRP ALA ARG VAL GLY SEQRES 3 B 1031 PRO ALA VAL GLU LEU ALA LEU ALA GLN VAL LYS ALA ARG SEQRES 4 B 1031 PRO ASP LEU LEU PRO GLY TRP THR VAL ARG THR VAL LEU SEQRES 5 B 1031 GLY SER SER GLU ASN ALA LEU GLY VAL CYS SER ASP THR SEQRES 6 B 1031 ALA ALA PRO LEU ALA ALA VAL ASP LEU LYS TRP GLU HIS SEQRES 7 B 1031 ASN PRO ALA VAL PHE LEU GLY PRO GLY CYS VAL TYR ALA SEQRES 8 B 1031 ALA ALA PRO VAL GLY ARG PHE THR ALA HIS TRP ARG VAL SEQRES 9 B 1031 PRO LEU LEU THR ALA GLY ALA PRO ALA LEU GLY PHE GLY SEQRES 10 B 1031 VAL LYS ASP GLU TYR ALA LEU THR THR ARG ALA GLY PRO SEQRES 11 B 1031 SER TYR ALA LYS LEU GLY ASP PHE VAL ALA ALA LEU HIS SEQRES 12 B 1031 ARG ARG LEU GLY TRP GLU ARG GLN ALA LEU MET LEU TYR SEQRES 13 B 1031 ALA TYR ARG PRO GLY ASP GLU GLU HIS CYS PHE PHE LEU SEQRES 14 B 1031 VAL GLU GLY LEU PHE MET ARG VAL ARG ASP ARG LEU ASN SEQRES 15 B 1031 ILE THR VAL ASP HIS LEU GLU PHE ALA GLU ASP ASP LEU SEQRES 16 B 1031 SER HIS TYR THR ARG LEU LEU ARG THR MET PRO ARG LYS SEQRES 17 B 1031 GLY ARG VAL ILE TYR ILE CYS SER SER PRO ASP ALA PHE SEQRES 18 B 1031 ARG THR LEU MET LEU LEU ALA LEU GLU ALA GLY LEU CYS SEQRES 19 B 1031 GLY GLU ASP TYR VAL PHE PHE HIS LEU ASP ILE PHE GLY SEQRES 20 B 1031 GLN SER LEU GLN GLY GLY GLN GLY PRO ALA PRO ARG ARG SEQRES 21 B 1031 PRO TRP GLU ARG GLY ASP GLY GLN ASP VAL SER ALA ARG SEQRES 22 B 1031 GLN ALA PHE GLN ALA ALA LYS ILE ILE THR TYR LYS ASP SEQRES 23 B 1031 PRO ASP ASN PRO GLU TYR LEU GLU PHE LEU LYS GLN LEU SEQRES 24 B 1031 LYS HIS LEU ALA TYR GLU GLN PHE ASN PHE THR MET GLU SEQRES 25 B 1031 ASP GLY LEU VAL ASN THR ILE PRO ALA SER PHE HIS ASP SEQRES 26 B 1031 GLY LEU LEU LEU TYR ILE GLN ALA VAL THR GLU THR LEU SEQRES 27 B 1031 ALA HIS GLY GLY THR VAL THR ASP GLY GLU ASN ILE THR SEQRES 28 B 1031 GLN ARG MET TRP ASN ARG SER PHE GLN GLY VAL THR GLY SEQRES 29 B 1031 TYR LEU LYS ILE ASP SER SER GLY ASP ARG GLU THR ASP SEQRES 30 B 1031 PHE SER LEU TRP ASP MET ASP PRO GLU ASN GLY ALA PHE SEQRES 31 B 1031 ARG VAL VAL LEU ASN TYR ASN GLY THR SER GLN GLU LEU SEQRES 32 B 1031 VAL ALA VAL SER GLY ARG LYS LEU ASN TRP PRO LEU GLY SEQRES 33 B 1031 TYR PRO PRO PRO ASP ILE PRO LYS CYS GLY PHE ASP ASN SEQRES 34 B 1031 GLU ASP PRO ALA CYS ASN GLN ASP HIS LEU SER THR LEU SEQRES 35 B 1031 GLU VAL LEU ALA LEU VAL GLY SER LEU SER LEU LEU GLY SEQRES 36 B 1031 ILE LEU ILE VAL SER PHE PHE ILE TYR ARG LYS MET GLN SEQRES 37 B 1031 LEU GLU LYS GLU LEU ALA SER GLU LEU TRP ARG VAL ARG SEQRES 38 B 1031 TRP GLU ASP VAL GLU PRO SER SER LEU GLU ARG HIS LEU SEQRES 39 B 1031 ARG SER ALA GLY SER ARG LEU THR LEU SER GLY ARG GLY SEQRES 40 B 1031 SER ASN TYR GLY SER LEU LEU THR THR GLU GLY GLN PHE SEQRES 41 B 1031 GLN VAL PHE ALA LYS THR ALA TYR TYR LYS GLY ASN LEU SEQRES 42 B 1031 VAL ALA VAL LYS ARG VAL ASN ARG LYS ARG ILE GLU LEU SEQRES 43 B 1031 THR ARG LYS VAL LEU PHE GLU LEU LYS HIS MET ARG ASP SEQRES 44 B 1031 VAL GLN ASN GLU HIS LEU THR ARG PHE VAL GLY ALA CYS SEQRES 45 B 1031 THR ASP PRO PRO ASN ILE CYS ILE LEU THR GLU TYR CYS SEQRES 46 B 1031 PRO ARG GLY SER LEU GLN ASP ILE LEU GLU ASN GLU SER SEQRES 47 B 1031 ILE THR LEU ASP TRP MET PHE ARG TYR SER LEU THR ASN SEQRES 48 B 1031 ASP ILE VAL LYS GLY MET LEU PHE LEU HIS ASN GLY ALA SEQRES 49 B 1031 ILE CYS SER HIS GLY ASN LEU LYS SER SER ASN CYS VAL SEQRES 50 B 1031 VAL ASP GLY ARG PHE VAL LEU LYS ILE THR ASP TYR GLY SEQRES 51 B 1031 LEU GLU SER PHE ARG ASP LEU ASP PRO GLU GLN GLY HIS SEQRES 52 B 1031 THR VAL TYR ALA LYS LYS LEU TRP THR ALA PRO GLU LEU SEQRES 53 B 1031 LEU ARG MET ALA SER PRO PRO VAL ARG GLY SER GLN ALA SEQRES 54 B 1031 GLY ASP VAL TYR SER PHE GLY ILE ILE LEU GLN GLU ILE SEQRES 55 B 1031 ALA LEU ARG SER GLY VAL PHE HIS VAL GLU GLY LEU ASP SEQRES 56 B 1031 LEU SER PRO LYS GLU ILE ILE GLU ARG VAL THR ARG GLY SEQRES 57 B 1031 GLU GLN PRO PRO PHE ARG PRO SER LEU ALA LEU GLN SER SEQRES 58 B 1031 HIS LEU GLU GLU LEU GLY LEU LEU MET GLN ARG CYS TRP SEQRES 59 B 1031 ALA GLU ASP PRO GLN GLU ARG PRO PRO PHE GLN GLN ILE SEQRES 60 B 1031 ARG LEU THR LEU ARG LYS PHE ASN ARG GLU ASN SER SER SEQRES 61 B 1031 ASN ILE LEU ASP ASN LEU LEU SER ARG MET GLU GLN TYR SEQRES 62 B 1031 ALA ASN ASN LEU GLU GLU LEU VAL GLU GLU ARG THR GLN SEQRES 63 B 1031 ALA TYR LEU GLU GLU LYS ARG LYS ALA GLU ALA LEU LEU SEQRES 64 B 1031 TYR GLN ILE LEU PRO HIS SER VAL ALA GLU GLN LEU LYS SEQRES 65 B 1031 ARG GLY GLU THR VAL GLN ALA GLU ALA PHE ASP SER VAL SEQRES 66 B 1031 THR ILE TYR PHE SER ASP ILE VAL GLY PHE THR ALA LEU SEQRES 67 B 1031 SER ALA GLU SER THR PRO MET GLN VAL VAL THR LEU LEU SEQRES 68 B 1031 ASN ASP LEU TYR THR CYS PHE ASP ALA VAL ILE ASP ASN SEQRES 69 B 1031 PHE ASP VAL TYR LYS VAL GLU THR ILE GLY ASP ALA TYR SEQRES 70 B 1031 MET VAL VAL SER GLY LEU PRO VAL ARG ASN GLY ARG LEU SEQRES 71 B 1031 HIS ALA CYS GLU VAL ALA ARG MET ALA LEU ALA LEU LEU SEQRES 72 B 1031 ASP ALA VAL ARG SER PHE ARG ILE ARG HIS ARG PRO GLN SEQRES 73 B 1031 GLU GLN LEU ARG LEU ARG ILE GLY ILE HIS THR GLY PRO SEQRES 74 B 1031 VAL CYS ALA GLY VAL VAL GLY LEU LYS MET PRO ARG TYR SEQRES 75 B 1031 CYS LEU PHE GLY ASP THR VAL ASN THR ALA SER ARG MET SEQRES 76 B 1031 GLU SER ASN GLY GLU ALA LEU LYS ILE HIS LEU SER SER SEQRES 77 B 1031 GLU THR LYS ALA VAL LEU GLU GLU PHE GLY GLY PHE GLU SEQRES 78 B 1031 LEU GLU LEU ARG GLY ASP VAL GLU MET LYS GLY LYS GLY SEQRES 79 B 1031 LYS VAL ARG THR TYR TRP LEU LEU GLY GLU ARG GLY SER SEQRES 80 B 1031 SER THR ARG GLY SEQRES 1 C 28 SER LEU ARG ARG SER SER CYS PHE GLY GLY ARG MET ASP SEQRES 2 C 28 ARG ILE GLY ALA GLN SER GLY LEU GLY CYS ASN SER PHE SEQRES 3 C 28 ARG TYR HET NAG E 1 14 HET NAG E 2 14 HET BMA E 3 11 HET NAG D 1 14 HET NAG D 2 14 HET BMA D 3 11 HET NAG F 1 14 HET NAG F 2 14 HET NAG I 1 14 HET NAG I 2 14 HET BMA I 3 11 HET NAG J 1 14 HET NAG J 2 14 HET NAG M 1 14 HET NAG M 2 14 HET BMA M 3 11 HET CL A1101 1 HET NAG A1102 14 HET CL B1101 1 HET NAG B1102 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM CL CHLORIDE ION HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 8 NAG 14(C8 H15 N O6) FORMUL 8 BMA 4(C6 H12 O6) FORMUL 14 CL 2(CL 1-) FORMUL 18 HOH *2(H2 O) HELIX 1 AA1 THR H 28 THR H 30 5 3 HELIX 2 AA2 ARG H 87 THR H 91 5 5 HELIX 3 AA3 GLN L 79 PHE L 83 5 5 HELIX 4 AA4 THR G 28 THR G 30 5 3 HELIX 5 AA5 ARG G 87 THR G 91 5 5 HELIX 6 AA6 GLN K 79 PHE K 83 5 5 HELIX 7 AA7 SER A 19 ARG A 37 1 19 HELIX 8 AA8 THR A 63 ASN A 77 1 15 HELIX 9 AA9 CYS A 86 ARG A 101 1 16 HELIX 10 AB1 ALA A 111 VAL A 116 5 6 HELIX 11 AB2 TYR A 130 GLY A 145 1 16 HELIX 12 AB3 GLU A 162 LEU A 179 1 18 HELIX 13 AB4 LEU A 193 MET A 203 1 11 HELIX 14 AB5 PRO A 204 LYS A 206 5 3 HELIX 15 AB6 SER A 215 GLY A 230 1 16 HELIX 16 AB7 GLY A 245 GLN A 249 5 5 HELIX 17 AB8 GLN A 266 GLN A 275 1 10 HELIX 18 AB9 ASN A 287 ASN A 306 1 20 HELIX 19 AC1 GLY A 312 VAL A 314 5 3 HELIX 20 AC2 ASN A 315 ALA A 337 1 23 HELIX 21 AC3 ASP A 344 TRP A 353 1 10 HELIX 22 AC4 SER B 19 LYS B 35 1 17 HELIX 23 AC5 THR B 63 ASN B 77 1 15 HELIX 24 AC6 CYS B 86 ARG B 101 1 16 HELIX 25 AC7 ALA B 111 VAL B 116 5 6 HELIX 26 AC8 SER B 129 GLY B 145 1 17 HELIX 27 AC9 GLU B 162 LEU B 179 1 18 HELIX 28 AD1 LEU B 193 MET B 203 1 11 HELIX 29 AD2 PRO B 204 LYS B 206 5 3 HELIX 30 AD3 SER B 215 GLY B 230 1 16 HELIX 31 AD4 GLY B 245 GLN B 249 5 5 HELIX 32 AD5 GLN B 266 PHE B 274 1 9 HELIX 33 AD6 ASN B 287 ASN B 306 1 20 HELIX 34 AD7 GLY B 312 VAL B 314 5 3 HELIX 35 AD8 ASN B 315 ALA B 337 1 23 HELIX 36 AD9 ASP B 344 TRP B 353 1 10 HELIX 37 AE1 ASP C 13 GLN C 18 5 6 SHEET 1 AA1 4 GLN H 3 GLN H 6 0 SHEET 2 AA1 4 SER H 17 SER H 25 -1 O LYS H 23 N VAL H 5 SHEET 3 AA1 4 THR H 78 SER H 84 -1 O MET H 81 N VAL H 20 SHEET 4 AA1 4 ILE H 68 THR H 69 -1 N THR H 69 O GLU H 82 SHEET 1 AA2 4 GLN H 3 GLN H 6 0 SHEET 2 AA2 4 SER H 17 SER H 25 -1 O LYS H 23 N VAL H 5 SHEET 3 AA2 4 THR H 78 SER H 84 -1 O MET H 81 N VAL H 20 SHEET 4 AA2 4 TRP H 72 ASP H 73 -1 N ASP H 73 O THR H 78 SHEET 1 AA3 6 GLU H 10 LYS H 12 0 SHEET 2 AA3 6 THR H 118 VAL H 122 1 O THR H 121 N LYS H 12 SHEET 3 AA3 6 ALA H 92 PRO H 101 -1 N ALA H 92 O VAL H 120 SHEET 4 AA3 6 TYR H 32 GLN H 39 -1 N TYR H 33 O GLY H 99 SHEET 5 AA3 6 LEU H 45 LYS H 52 -1 O GLU H 46 N ARG H 38 SHEET 6 AA3 6 GLY H 57 THR H 58 -1 O GLY H 57 N LYS H 52 SHEET 1 AA4 4 GLU H 10 LYS H 12 0 SHEET 2 AA4 4 THR H 118 VAL H 122 1 O THR H 121 N LYS H 12 SHEET 3 AA4 4 ALA H 92 PRO H 101 -1 N ALA H 92 O VAL H 120 SHEET 4 AA4 4 VAL H 113 TRP H 114 -1 O VAL H 113 N ARG H 98 SHEET 1 AA5 4 MET L 4 GLN L 6 0 SHEET 2 AA5 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AA5 4 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AA5 4 PHE L 62 SER L 67 -1 N SER L 65 O THR L 72 SHEET 1 AA6 6 LEU L 11 ALA L 13 0 SHEET 2 AA6 6 THR L 101 ILE L 105 1 O GLU L 104 N ALA L 13 SHEET 3 AA6 6 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 101 SHEET 4 AA6 6 LEU L 33 GLN L 38 -1 N GLN L 38 O THR L 85 SHEET 5 AA6 6 LYS L 45 TYR L 49 -1 O LEU L 47 N TRP L 35 SHEET 6 AA6 6 SER L 53 LEU L 54 -1 O SER L 53 N TYR L 49 SHEET 1 AA7 4 LEU L 11 ALA L 13 0 SHEET 2 AA7 4 THR L 101 ILE L 105 1 O GLU L 104 N ALA L 13 SHEET 3 AA7 4 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 101 SHEET 4 AA7 4 THR L 96 PHE L 97 -1 O THR L 96 N GLN L 90 SHEET 1 AA8 4 GLN G 3 GLN G 6 0 SHEET 2 AA8 4 SER G 17 SER G 25 -1 O LYS G 23 N VAL G 5 SHEET 3 AA8 4 THR G 78 SER G 84 -1 O LEU G 83 N VAL G 18 SHEET 4 AA8 4 ILE G 68 THR G 69 -1 N THR G 69 O GLU G 82 SHEET 1 AA9 4 GLN G 3 GLN G 6 0 SHEET 2 AA9 4 SER G 17 SER G 25 -1 O LYS G 23 N VAL G 5 SHEET 3 AA9 4 THR G 78 SER G 84 -1 O LEU G 83 N VAL G 18 SHEET 4 AA9 4 TRP G 72 ASP G 73 -1 N ASP G 73 O THR G 78 SHEET 1 AB1 6 GLU G 10 LYS G 12 0 SHEET 2 AB1 6 THR G 118 VAL G 122 1 O THR G 121 N GLU G 10 SHEET 3 AB1 6 ALA G 92 PRO G 101 -1 N ALA G 92 O VAL G 120 SHEET 4 AB1 6 TYR G 32 GLN G 39 -1 N TYR G 33 O GLY G 99 SHEET 5 AB1 6 LEU G 45 LYS G 52 -1 O GLU G 46 N ARG G 38 SHEET 6 AB1 6 GLY G 57 THR G 58 -1 O GLY G 57 N LYS G 52 SHEET 1 AB2 4 GLU G 10 LYS G 12 0 SHEET 2 AB2 4 THR G 118 VAL G 122 1 O THR G 121 N GLU G 10 SHEET 3 AB2 4 ALA G 92 PRO G 101 -1 N ALA G 92 O VAL G 120 SHEET 4 AB2 4 VAL G 113 TRP G 114 -1 O VAL G 113 N ARG G 98 SHEET 1 AB3 3 MET K 4 GLN K 6 0 SHEET 2 AB3 3 VAL K 19 ILE K 29 -1 O ARG K 24 N THR K 5 SHEET 3 AB3 3 PHE K 62 ILE K 75 -1 O GLY K 68 N ILE K 29 SHEET 1 AB4 6 LEU K 11 ALA K 13 0 SHEET 2 AB4 6 THR K 101 ILE K 105 1 O GLU K 104 N ALA K 13 SHEET 3 AB4 6 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 101 SHEET 4 AB4 6 LEU K 33 GLN K 38 -1 N ASN K 34 O GLN K 89 SHEET 5 AB4 6 LYS K 45 TYR K 49 -1 O LEU K 47 N TRP K 35 SHEET 6 AB4 6 SER K 53 LEU K 54 -1 O SER K 53 N TYR K 49 SHEET 1 AB5 4 LEU K 11 ALA K 13 0 SHEET 2 AB5 4 THR K 101 ILE K 105 1 O GLU K 104 N ALA K 13 SHEET 3 AB5 4 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 101 SHEET 4 AB5 4 THR K 96 PHE K 97 -1 O THR K 96 N GLN K 90 SHEET 1 AB6 5 TRP A 44 SER A 52 0 SHEET 2 AB6 5 GLY A 1 LEU A 9 1 N VAL A 5 O ARG A 47 SHEET 3 AB6 5 VAL A 80 LEU A 82 1 O LEU A 82 N ALA A 6 SHEET 4 AB6 5 LEU A 104 THR A 106 1 O LEU A 105 N PHE A 81 SHEET 5 AB6 5 THR A 123 ARG A 125 1 O THR A 124 N LEU A 104 SHEET 1 AB7 8 THR A 182 ALA A 189 0 SHEET 2 AB7 8 GLN A 149 TYR A 156 1 N ALA A 150 O ASP A 184 SHEET 3 AB7 8 VAL A 209 CYS A 213 1 O VAL A 209 N LEU A 151 SHEET 4 AB7 8 VAL A 237 LEU A 241 1 O PHE A 239 N ILE A 212 SHEET 5 AB7 8 ALA A 277 TYR A 282 1 O ILE A 280 N HIS A 240 SHEET 6 AB7 8 PHE A 376 MET A 381 -1 O TRP A 379 N ILE A 279 SHEET 7 AB7 8 PHE A 388 ASN A 395 -1 O VAL A 391 N LEU A 378 SHEET 8 AB7 8 GLU A 400 ALA A 403 -1 O VAL A 402 N ASN A 393 SHEET 1 AB8 2 SER A 356 GLY A 359 0 SHEET 2 AB8 2 GLY A 362 LYS A 365 -1 O GLY A 362 N GLY A 359 SHEET 1 AB9 5 TRP B 44 SER B 52 0 SHEET 2 AB9 5 GLY B 1 LEU B 9 1 N VAL B 5 O ARG B 47 SHEET 3 AB9 5 VAL B 80 LEU B 82 1 O LEU B 82 N ALA B 6 SHEET 4 AB9 5 LEU B 104 THR B 106 1 O LEU B 105 N PHE B 81 SHEET 5 AB9 5 THR B 123 ARG B 125 1 O THR B 124 N LEU B 104 SHEET 1 AC1 8 THR B 182 ALA B 189 0 SHEET 2 AC1 8 GLN B 149 TYR B 156 1 N ALA B 150 O ASP B 184 SHEET 3 AC1 8 VAL B 209 CYS B 213 1 O CYS B 213 N ALA B 155 SHEET 4 AC1 8 VAL B 237 LEU B 241 1 O PHE B 239 N ILE B 212 SHEET 5 AC1 8 ALA B 277 TYR B 282 1 O ILE B 280 N HIS B 240 SHEET 6 AC1 8 PHE B 376 MET B 381 -1 O SER B 377 N THR B 281 SHEET 7 AC1 8 PHE B 388 ASN B 395 -1 O VAL B 391 N LEU B 378 SHEET 8 AC1 8 GLU B 400 ALA B 403 -1 O VAL B 402 N ASN B 393 SHEET 1 AC2 2 SER B 356 GLN B 358 0 SHEET 2 AC2 2 TYR B 363 LYS B 365 -1 O LEU B 364 N PHE B 357 SSBOND 1 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 2 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 3 CYS G 22 CYS G 96 1555 1555 2.03 SSBOND 4 CYS K 23 CYS K 88 1555 1555 2.04 SSBOND 5 CYS A 60 CYS A 86 1555 1555 2.04 SSBOND 6 CYS B 60 CYS B 86 1555 1555 2.04 SSBOND 7 CYS C 7 CYS C 23 1555 1555 2.03 LINK ND2 ASN A 2 C1 NAG F 1 1555 1555 1.43 LINK ND2 ASN A 13 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN A 354 C1 NAG A1102 1555 1555 1.44 LINK ND2 ASN A 395 C1 NAG D 1 1555 1555 1.44 LINK ND2 ASN B 2 C1 NAG J 1 1555 1555 1.43 LINK ND2 ASN B 13 C1 NAG M 1 1555 1555 1.43 LINK ND2 ASN B 354 C1 NAG B1102 1555 1555 1.44 LINK ND2 ASN B 395 C1 NAG I 1 1555 1555 1.44 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.44 LINK O4 NAG E 2 C1 BMA E 3 1555 1555 1.44 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.43 LINK O4 NAG D 2 C1 BMA D 3 1555 1555 1.44 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.43 LINK O4 NAG I 2 C1 BMA I 3 1555 1555 1.44 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000