HEADER VIRAL PROTEIN/IMMUNE SYSTEM 16-OCT-24 9DZQ TITLE CRYOEM STRUCTURE OF THE HUMAN ANTIBODIES PIV3HN-05 AND PIV3HN-13 IN TITLE 2 COMPLEX WITH THE PARAINFLUENZA VIRUS HEMAGGLUTININ-NEURAMINIDASE TITLE 3 PROTEIN CAVEAT 9DZQ RESIDUES ASP C 63 AND THR C 64 THAT ARE NEXT TO EACH OTHER CAVEAT 2 9DZQ IN THE SAMPLE SEQUENCE ARE NOT PROPERLY LINKED: DISTANCE CAVEAT 3 9DZQ BETWEEN C AND N IS 7.68. RESIDUES PHE C 76 AND GLN C 90 CAVEAT 4 9DZQ THAT ARE NEXT TO EACH OTHER IN THE SAMPLE SEQUENCE ARE NOT CAVEAT 5 9DZQ PROPERLY LINKED: DISTANCE BETWEEN C AND N IS 6.72. RESIDUES CAVEAT 6 9DZQ THR C 99 AND VAL C 105 THAT ARE NEXT TO EACH OTHER IN THE CAVEAT 7 9DZQ SAMPLE SEQUENCE ARE NOT PROPERLY LINKED: DISTANCE BETWEEN C CAVEAT 8 9DZQ AND N IS 13.63. RESIDUES ASP D 63 AND THR D 64 THAT ARE CAVEAT 9 9DZQ NEXT TO EACH OTHER IN THE SAMPLE SEQUENCE ARE NOT PROPERLY CAVEAT 10 9DZQ LINKED: DISTANCE BETWEEN C AND N IS 7.92. RESIDUES PHE D 76 CAVEAT 11 9DZQ AND GLN D 90 THAT ARE NEXT TO EACH OTHER IN THE SAMPLE CAVEAT 12 9DZQ SEQUENCE ARE NOT PROPERLY LINKED: DISTANCE BETWEEN C AND N CAVEAT 13 9DZQ IS 6.77. RESIDUES THR D 99 AND VAL D 105 THAT ARE NEXT TO CAVEAT 14 9DZQ EACH OTHER IN THE SAMPLE SEQUENCE ARE NOT PROPERLY LINKED: CAVEAT 15 9DZQ DISTANCE BETWEEN C AND N IS 13.39. RESIDUES TYR E 42 AND CAVEAT 16 9DZQ GLN E 43 THAT ARE NEXT TO EACH OTHER IN THE SAMPLE SEQUENCE CAVEAT 17 9DZQ ARE NOT PROPERLY LINKED: DISTANCE BETWEEN C AND N IS 3.87. CAVEAT 18 9DZQ RESIDUES SER E 77 AND TYR E 102 THAT ARE NEXT TO EACH OTHER CAVEAT 19 9DZQ IN THE SAMPLE SEQUENCE ARE NOT PROPERLY LINKED: DISTANCE CAVEAT 20 9DZQ BETWEEN C AND N IS 12.17. RESIDUES TYR F 42 AND GLN F 43 CAVEAT 21 9DZQ THAT ARE NEXT TO EACH OTHER IN THE SAMPLE SEQUENCE ARE NOT CAVEAT 22 9DZQ PROPERLY LINKED: DISTANCE BETWEEN C AND N IS 3.90. RESIDUES CAVEAT 23 9DZQ SER F 77 AND TYR F 102 THAT ARE NEXT TO EACH OTHER IN THE CAVEAT 24 9DZQ SAMPLE SEQUENCE ARE NOT PROPERLY LINKED: DISTANCE BETWEEN C CAVEAT 25 9DZQ AND N IS 12.15. RESIDUES GLY G 121 AND GLY G 124 THAT ARE CAVEAT 26 9DZQ NEXT TO EACH OTHER IN THE SAMPLE SEQUENCE ARE NOT PROPERLY CAVEAT 27 9DZQ LINKED: DISTANCE BETWEEN C AND N IS 5.67. RESIDUES ASP H CAVEAT 28 9DZQ 111 AND GLY H 112A THAT ARE NEXT TO EACH OTHER IN THE CAVEAT 29 9DZQ SAMPLE SEQUENCE ARE NOT PROPERLY LINKED. RESIDUES GLY H 121 CAVEAT 30 9DZQ AND GLY H 124 THAT ARE NEXT TO EACH OTHER IN THE SAMPLE CAVEAT 31 9DZQ SEQUENCE ARE NOT PROPERLY LINKED: DISTANCE BETWEEN C AND N CAVEAT 32 9DZQ IS 5.69. COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ-NEURAMINIDASE; COMPND 3 CHAIN: A, B; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: HUMAN ANTIBODY PIV3HN-05 HEAVY CHAIN; COMPND 7 CHAIN: C, D; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: HUMAN ANTIBODY PIV3HN-05 LIGHT CHAIN; COMPND 11 CHAIN: E, F; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: HUMAN ANTIBODY PIV3HN-13 HEAVY CHAIN; COMPND 15 CHAIN: G, H; COMPND 16 ENGINEERED: YES; COMPND 17 MOL_ID: 5; COMPND 18 MOLECULE: HUMAN ANTIBODY PIV3HN-13 LIGHT CHAIN; COMPND 19 CHAIN: I, J; COMPND 20 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN RESPIROVIRUS 3; SOURCE 3 ORGANISM_TAXID: 11216; SOURCE 4 GENE: HN; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 17 MOL_ID: 4; SOURCE 18 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 19 ORGANISM_TAXID: 9606; SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 22 MOL_ID: 5; SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 24 ORGANISM_TAXID: 9606; SOURCE 25 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS HEMAGGLUTININ-NEURAMINIDASE, HUMAN MONOCLONAL ANTIBODY, VIRAL KEYWDS 2 PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR J.J.MOUSA,R.J.MILLER REVDAT 1 04-DEC-24 9DZQ 0 JRNL AUTH J.J.MOUSA,R.J.MILLER JRNL TITL THE STRUCTURAL BASIS OF PROTECTIVE AND NONPROTECTIVE HUMAN JRNL TITL 2 MONOCLONAL ANTIBODIES TARGETING THE PARAINFLUENZA VIRUS TYPE JRNL TITL 3 3 HEMAGGLUTININ-NEURAMINIDASE JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.57 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.570 REMARK 3 NUMBER OF PARTICLES : 139192 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9DZQ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 17-OCT-24. REMARK 100 THE DEPOSITION ID IS D_1000289190. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : COMPLEX OF THE PIV3 HN PROTEIN REMARK 245 WITH TWO HUMAN ANTIBODIES REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K2 IS (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2600.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5280.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DECAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, G, I, B, D, F, H, J REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 HIS A -5 REMARK 465 HIS A -4 REMARK 465 HIS A -3 REMARK 465 HIS A -2 REMARK 465 HIS A -1 REMARK 465 HIS A 0 REMARK 465 SER A 1 REMARK 465 LEU A 2 REMARK 465 VAL A 3 REMARK 465 PRO A 4 REMARK 465 ARG A 5 REMARK 465 GLY A 6 REMARK 465 SER A 7 REMARK 465 ILE A 8 REMARK 465 SER A 9 REMARK 465 GLU A 10 REMARK 465 ILE A 11 REMARK 465 THR A 12 REMARK 465 ILE A 13 REMARK 465 ASN A 17 REMARK 465 GLN A 18 REMARK 465 GLU A 19 REMARK 465 VAL A 20 REMARK 465 LEU A 21 REMARK 465 PRO A 22 REMARK 465 GLN A 23 REMARK 465 TYR A 178 REMARK 465 ASP A 179 REMARK 465 GLY A 180 REMARK 465 SER A 181 REMARK 465 ILE A 182 REMARK 465 SER A 183 REMARK 465 THR A 184 REMARK 465 ASP A 195 REMARK 465 GLN A 196 REMARK 465 PRO A 197 REMARK 465 GLY A 221 REMARK 465 GLY A 222 REMARK 465 LEU A 223 REMARK 465 GLU A 224 REMARK 465 HIS A 225 REMARK 465 PRO A 226 REMARK 465 ILE A 227 REMARK 465 ASN A 228 REMARK 465 GLU A 229 REMARK 465 ASN A 230 REMARK 465 ARG A 259 REMARK 465 MET A 260 REMARK 465 VAL A 261 REMARK 465 GLY A 270 REMARK 465 LEU A 271 REMARK 465 ASN A 272 REMARK 465 SER A 273 REMARK 465 THR A 281 REMARK 465 ILE A 282 REMARK 465 SER A 283 REMARK 465 MET A 284 REMARK 465 ARG A 285 REMARK 465 GLN A 286 REMARK 465 SER A 326 REMARK 465 ASP A 327 REMARK 465 ILE A 328 REMARK 465 SER A 455 REMARK 465 GLU C 1 REMARK 465 VAL C 2 REMARK 465 GLN C 3 REMARK 465 LEU C 4 REMARK 465 VAL C 5 REMARK 465 GLU C 6 REMARK 465 SER C 7 REMARK 465 GLY C 8 REMARK 465 GLY C 9 REMARK 465 GLY C 10 REMARK 465 VAL C 11 REMARK 465 VAL C 12 REMARK 465 GLN C 13 REMARK 465 PRO C 14 REMARK 465 GLY C 15 REMARK 465 GLY C 16 REMARK 465 SER C 17 REMARK 465 LEU C 18 REMARK 465 ARG C 19 REMARK 465 LEU C 20 REMARK 465 SER C 21 REMARK 465 CYS C 22 REMARK 465 VAL C 23 REMARK 465 ALA C 24 REMARK 465 SER C 25 REMARK 465 GLY C 26 REMARK 465 LEU C 27 REMARK 465 SER C 28 REMARK 465 ASN C 56A REMARK 465 GLY C 56B REMARK 465 ASP C 56C REMARK 465 THR C 56D REMARK 465 THR C 69 REMARK 465 ILE C 70 REMARK 465 SER C 71 REMARK 465 ARG C 72 REMARK 465 ASP C 73 REMARK 465 ASN C 74 REMARK 465 ALA C 75 REMARK 465 LYS C 76 REMARK 465 ASN C 77 REMARK 465 THR C 78 REMARK 465 LEU C 79 REMARK 465 TYR C 80 REMARK 465 LEU C 81 REMARK 465 ALA C 92 REMARK 465 VAL C 93 REMARK 465 TYR C 94 REMARK 465 PHE C 95 REMARK 465 CYS C 96 REMARK 465 GLY C 121 REMARK 465 GLN C 122 REMARK 465 GLY C 123 REMARK 465 THR C 124 REMARK 465 LEU C 125 REMARK 465 VAL C 126 REMARK 465 THR C 127 REMARK 465 VAL C 128 REMARK 465 SER C 129 REMARK 465 SER C 130 REMARK 465 ALA C 131 REMARK 465 SER C 132 REMARK 465 THR C 133 REMARK 465 LYS C 134 REMARK 465 GLY C 135 REMARK 465 PRO C 136 REMARK 465 SER C 137 REMARK 465 VAL C 138 REMARK 465 PHE C 139 REMARK 465 PRO C 140 REMARK 465 LEU C 141 REMARK 465 ALA C 142 REMARK 465 PRO C 143 REMARK 465 SER C 144 REMARK 465 SER C 145 REMARK 465 LYS C 146 REMARK 465 SER C 147 REMARK 465 THR C 148 REMARK 465 SER C 149 REMARK 465 GLY C 150 REMARK 465 GLY C 151 REMARK 465 THR C 152 REMARK 465 ALA C 153 REMARK 465 ALA C 154 REMARK 465 LEU C 155 REMARK 465 GLY C 156 REMARK 465 CYS C 157 REMARK 465 LEU C 158 REMARK 465 VAL C 159 REMARK 465 LYS C 160 REMARK 465 ASP C 161 REMARK 465 TYR C 162 REMARK 465 PHE C 163 REMARK 465 PRO C 164 REMARK 465 GLU C 165 REMARK 465 PRO C 166 REMARK 465 VAL C 167 REMARK 465 THR C 168 REMARK 465 VAL C 169 REMARK 465 SER C 170 REMARK 465 TRP C 171 REMARK 465 ASN C 172 REMARK 465 SER C 173 REMARK 465 GLY C 174 REMARK 465 ALA C 175 REMARK 465 LEU C 176 REMARK 465 THR C 177 REMARK 465 SER C 178 REMARK 465 GLY C 179 REMARK 465 VAL C 180 REMARK 465 HIS C 181 REMARK 465 THR C 182 REMARK 465 PHE C 183 REMARK 465 PRO C 184 REMARK 465 ALA C 185 REMARK 465 VAL C 186 REMARK 465 LEU C 187 REMARK 465 GLN C 188 REMARK 465 SER C 189 REMARK 465 SER C 190 REMARK 465 GLY C 191 REMARK 465 LEU C 192 REMARK 465 TYR C 193 REMARK 465 SER C 194 REMARK 465 LEU C 195 REMARK 465 SER C 196 REMARK 465 SER C 197 REMARK 465 VAL C 198 REMARK 465 VAL C 199 REMARK 465 THR C 200 REMARK 465 VAL C 201 REMARK 465 PRO C 202 REMARK 465 SER C 203 REMARK 465 SER C 204 REMARK 465 SER C 205 REMARK 465 LEU C 206 REMARK 465 GLY C 207 REMARK 465 THR C 208 REMARK 465 GLN C 209 REMARK 465 THR C 210 REMARK 465 TYR C 211 REMARK 465 ILE C 212 REMARK 465 CYS C 213 REMARK 465 ASN C 214 REMARK 465 VAL C 215 REMARK 465 ASN C 216 REMARK 465 HIS C 217 REMARK 465 LYS C 218 REMARK 465 PRO C 219 REMARK 465 SER C 220 REMARK 465 ASN C 221 REMARK 465 THR C 222 REMARK 465 LYS C 223 REMARK 465 VAL C 224 REMARK 465 ASP C 225 REMARK 465 LYS C 226 REMARK 465 ARG C 227 REMARK 465 VAL C 228 REMARK 465 GLU C 229 REMARK 465 PRO C 230 REMARK 465 LYS C 231 REMARK 465 SER C 232 REMARK 465 CYS C 233 REMARK 465 GLN E 1 REMARK 465 SER E 2 REMARK 465 VAL E 3 REMARK 465 LEU E 4 REMARK 465 THR E 5 REMARK 465 GLN E 6 REMARK 465 PRO E 7 REMARK 465 PRO E 8 REMARK 465 SER E 9 REMARK 465 ALA E 10 REMARK 465 SER E 11 REMARK 465 GLY E 12 REMARK 465 THR E 13 REMARK 465 PRO E 14 REMARK 465 GLY E 15 REMARK 465 GLN E 16 REMARK 465 GLY E 17 REMARK 465 VAL E 18 REMARK 465 THR E 19 REMARK 465 ILE E 20 REMARK 465 SER E 21 REMARK 465 CYS E 22 REMARK 465 SER E 23 REMARK 465 GLY E 24 REMARK 465 SER E 25 REMARK 465 ASN E 26 REMARK 465 SER E 27 REMARK 465 ASN E 28 REMARK 465 TYR E 36A REMARK 465 GLN E 36B REMARK 465 GLY E 65 REMARK 465 SER E 66 REMARK 465 ARG E 67 REMARK 465 SER E 68 REMARK 465 GLY E 69 REMARK 465 THR E 70 REMARK 465 SER E 71 REMARK 465 ALA E 72 REMARK 465 SER E 73 REMARK 465 LEU E 74 REMARK 465 ALA E 75 REMARK 465 ILE E 76 REMARK 465 SER E 77 REMARK 465 GLY E 78 REMARK 465 LEU E 79 REMARK 465 GLN E 80 REMARK 465 SER E 81 REMARK 465 GLU E 82 REMARK 465 ASP E 83 REMARK 465 GLU E 84 REMARK 465 ALA E 85 REMARK 465 VAL E 86 REMARK 465 GLY E 103 REMARK 465 GLY E 104 REMARK 465 GLY E 105 REMARK 465 THR E 106 REMARK 465 LYS E 107 REMARK 465 LEU E 108 REMARK 465 THR E 109 REMARK 465 VAL E 110 REMARK 465 LEU E 111 REMARK 465 ARG E 112 REMARK 465 GLN E 113 REMARK 465 PRO E 114 REMARK 465 LYS E 115 REMARK 465 ALA E 116 REMARK 465 ALA E 117 REMARK 465 PRO E 118 REMARK 465 SER E 119 REMARK 465 VAL E 120 REMARK 465 THR E 121 REMARK 465 LEU E 122 REMARK 465 PHE E 123 REMARK 465 PRO E 124 REMARK 465 PRO E 125 REMARK 465 SER E 126 REMARK 465 SER E 127 REMARK 465 GLU E 128 REMARK 465 GLU E 129 REMARK 465 LEU E 130 REMARK 465 GLN E 131 REMARK 465 ALA E 132 REMARK 465 ASN E 133 REMARK 465 LYS E 134 REMARK 465 ALA E 135 REMARK 465 THR E 136 REMARK 465 LEU E 137 REMARK 465 VAL E 138 REMARK 465 CYS E 139 REMARK 465 LEU E 140 REMARK 465 ILE E 141 REMARK 465 SER E 142 REMARK 465 ASP E 143 REMARK 465 PHE E 144 REMARK 465 TYR E 145 REMARK 465 PRO E 146 REMARK 465 GLY E 147 REMARK 465 ALA E 148 REMARK 465 VAL E 149 REMARK 465 THR E 150 REMARK 465 VAL E 151 REMARK 465 ALA E 152 REMARK 465 TRP E 153 REMARK 465 LYS E 154 REMARK 465 ALA E 155 REMARK 465 ASP E 156 REMARK 465 SER E 157 REMARK 465 SER E 158 REMARK 465 PRO E 159 REMARK 465 VAL E 160 REMARK 465 LYS E 161 REMARK 465 ALA E 162 REMARK 465 GLY E 163 REMARK 465 VAL E 164 REMARK 465 GLU E 165 REMARK 465 THR E 166 REMARK 465 THR E 167 REMARK 465 THR E 168 REMARK 465 PRO E 169 REMARK 465 SER E 170 REMARK 465 LYS E 171 REMARK 465 GLN E 172 REMARK 465 SER E 173 REMARK 465 ASN E 174 REMARK 465 ASN E 175 REMARK 465 LYS E 176 REMARK 465 TYR E 177 REMARK 465 ALA E 178 REMARK 465 ALA E 179 REMARK 465 SER E 180 REMARK 465 SER E 181 REMARK 465 TYR E 182 REMARK 465 LEU E 183 REMARK 465 SER E 184 REMARK 465 LEU E 185 REMARK 465 THR E 186 REMARK 465 PRO E 187 REMARK 465 GLU E 188 REMARK 465 GLN E 189 REMARK 465 TRP E 190 REMARK 465 LYS E 191 REMARK 465 SER E 192 REMARK 465 HIS E 193 REMARK 465 ARG E 194 REMARK 465 SER E 195 REMARK 465 TYR E 196 REMARK 465 SER E 197 REMARK 465 CYS E 198 REMARK 465 GLN E 199 REMARK 465 VAL E 200 REMARK 465 THR E 201 REMARK 465 HIS E 202 REMARK 465 GLU E 203 REMARK 465 GLY E 204 REMARK 465 SER E 205 REMARK 465 THR E 206 REMARK 465 VAL E 207 REMARK 465 GLU E 208 REMARK 465 LYS E 209 REMARK 465 THR E 210 REMARK 465 VAL E 211 REMARK 465 ALA E 212 REMARK 465 PRO E 213 REMARK 465 THR E 214 REMARK 465 GLU E 215 REMARK 465 CYS E 216 REMARK 465 SER E 217 REMARK 465 GLU G 1 REMARK 465 ASN G 115 REMARK 465 PRO G 116 REMARK 465 PRO G 121 REMARK 465 ALA G 122 REMARK 465 SER G 123 REMARK 465 THR G 124 REMARK 465 LYS G 125 REMARK 465 GLY G 126 REMARK 465 PRO G 127 REMARK 465 SER G 128 REMARK 465 VAL G 129 REMARK 465 PHE G 130 REMARK 465 PRO G 131 REMARK 465 LEU G 132 REMARK 465 ALA G 133 REMARK 465 PRO G 134 REMARK 465 SER G 135 REMARK 465 SER G 136 REMARK 465 LYS G 137 REMARK 465 SER G 138 REMARK 465 THR G 139 REMARK 465 SER G 140 REMARK 465 GLY G 141 REMARK 465 GLY G 142 REMARK 465 THR G 143 REMARK 465 ALA G 144 REMARK 465 ALA G 145 REMARK 465 LEU G 146 REMARK 465 GLY G 147 REMARK 465 CYS G 148 REMARK 465 LEU G 149 REMARK 465 VAL G 150 REMARK 465 LYS G 151 REMARK 465 ASP G 152 REMARK 465 TYR G 153 REMARK 465 PHE G 154 REMARK 465 PRO G 155 REMARK 465 GLU G 156 REMARK 465 PRO G 157 REMARK 465 VAL G 158 REMARK 465 THR G 159 REMARK 465 VAL G 160 REMARK 465 SER G 161 REMARK 465 TRP G 162 REMARK 465 ASN G 163 REMARK 465 SER G 164 REMARK 465 GLY G 165 REMARK 465 ALA G 166 REMARK 465 LEU G 167 REMARK 465 THR G 168 REMARK 465 SER G 169 REMARK 465 GLY G 170 REMARK 465 VAL G 171 REMARK 465 HIS G 172 REMARK 465 THR G 173 REMARK 465 PHE G 174 REMARK 465 PRO G 175 REMARK 465 ALA G 176 REMARK 465 VAL G 177 REMARK 465 LEU G 178 REMARK 465 GLN G 179 REMARK 465 SER G 180 REMARK 465 SER G 181 REMARK 465 GLY G 182 REMARK 465 LEU G 183 REMARK 465 TYR G 184 REMARK 465 SER G 185 REMARK 465 LEU G 186 REMARK 465 SER G 187 REMARK 465 SER G 188 REMARK 465 VAL G 189 REMARK 465 VAL G 190 REMARK 465 THR G 191 REMARK 465 VAL G 192 REMARK 465 PRO G 193 REMARK 465 SER G 194 REMARK 465 SER G 195 REMARK 465 SER G 196 REMARK 465 LEU G 197 REMARK 465 GLY G 198 REMARK 465 THR G 199 REMARK 465 GLN G 200 REMARK 465 THR G 201 REMARK 465 TYR G 202 REMARK 465 ILE G 203 REMARK 465 CYS G 204 REMARK 465 ASN G 205 REMARK 465 VAL G 206 REMARK 465 ASN G 207 REMARK 465 HIS G 208 REMARK 465 LYS G 209 REMARK 465 PRO G 210 REMARK 465 SER G 211 REMARK 465 ASN G 212 REMARK 465 THR G 213 REMARK 465 LYS G 214 REMARK 465 VAL G 215 REMARK 465 ASP G 216 REMARK 465 LYS G 217 REMARK 465 ARG G 218 REMARK 465 VAL G 219 REMARK 465 GLU G 220 REMARK 465 PRO G 221 REMARK 465 LYS G 222 REMARK 465 SER G 223 REMARK 465 CYS G 224 REMARK 465 ASP I 1 REMARK 465 ARG I 112 REMARK 465 THR I 113 REMARK 465 VAL I 114 REMARK 465 ALA I 115 REMARK 465 ALA I 116 REMARK 465 PRO I 117 REMARK 465 SER I 118 REMARK 465 VAL I 119 REMARK 465 PHE I 120 REMARK 465 ILE I 121 REMARK 465 PHE I 122 REMARK 465 PRO I 123 REMARK 465 PRO I 124 REMARK 465 SER I 125 REMARK 465 ASP I 126 REMARK 465 GLU I 127 REMARK 465 GLN I 128 REMARK 465 LEU I 129 REMARK 465 LYS I 130 REMARK 465 SER I 131 REMARK 465 GLY I 132 REMARK 465 THR I 133 REMARK 465 ALA I 134 REMARK 465 SER I 135 REMARK 465 VAL I 136 REMARK 465 VAL I 137 REMARK 465 CYS I 138 REMARK 465 LEU I 139 REMARK 465 LEU I 140 REMARK 465 ASN I 141 REMARK 465 ASN I 142 REMARK 465 PHE I 143 REMARK 465 TYR I 144 REMARK 465 PRO I 145 REMARK 465 ARG I 146 REMARK 465 GLU I 147 REMARK 465 ALA I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 GLN I 151 REMARK 465 TRP I 152 REMARK 465 LYS I 153 REMARK 465 VAL I 154 REMARK 465 ASP I 155 REMARK 465 ASN I 156 REMARK 465 ALA I 157 REMARK 465 LEU I 158 REMARK 465 GLN I 159 REMARK 465 SER I 160 REMARK 465 GLY I 161 REMARK 465 ASN I 162 REMARK 465 SER I 163 REMARK 465 GLN I 164 REMARK 465 GLU I 165 REMARK 465 SER I 166 REMARK 465 VAL I 167 REMARK 465 THR I 168 REMARK 465 GLU I 169 REMARK 465 GLN I 170 REMARK 465 ASP I 171 REMARK 465 SER I 172 REMARK 465 LYS I 173 REMARK 465 ASP I 174 REMARK 465 SER I 175 REMARK 465 THR I 176 REMARK 465 TYR I 177 REMARK 465 SER I 178 REMARK 465 LEU I 179 REMARK 465 SER I 180 REMARK 465 SER I 181 REMARK 465 THR I 182 REMARK 465 LEU I 183 REMARK 465 THR I 184 REMARK 465 LEU I 185 REMARK 465 SER I 186 REMARK 465 LYS I 187 REMARK 465 ALA I 188 REMARK 465 ASP I 189 REMARK 465 TYR I 190 REMARK 465 GLU I 191 REMARK 465 LYS I 192 REMARK 465 HIS I 193 REMARK 465 LYS I 194 REMARK 465 VAL I 195 REMARK 465 TYR I 196 REMARK 465 ALA I 197 REMARK 465 CYS I 198 REMARK 465 GLU I 199 REMARK 465 VAL I 200 REMARK 465 THR I 201 REMARK 465 HIS I 202 REMARK 465 GLN I 203 REMARK 465 GLY I 204 REMARK 465 LEU I 205 REMARK 465 SER I 206 REMARK 465 SER I 207 REMARK 465 PRO I 208 REMARK 465 VAL I 209 REMARK 465 THR I 210 REMARK 465 LYS I 211 REMARK 465 SER I 212 REMARK 465 PHE I 213 REMARK 465 ASN I 214 REMARK 465 ARG I 215 REMARK 465 GLY I 216 REMARK 465 GLU I 217 REMARK 465 CYS I 218 REMARK 465 HIS B -5 REMARK 465 HIS B -4 REMARK 465 HIS B -3 REMARK 465 HIS B -2 REMARK 465 HIS B -1 REMARK 465 HIS B 0 REMARK 465 SER B 1 REMARK 465 LEU B 2 REMARK 465 VAL B 3 REMARK 465 PRO B 4 REMARK 465 ARG B 5 REMARK 465 GLY B 6 REMARK 465 SER B 7 REMARK 465 ILE B 8 REMARK 465 SER B 9 REMARK 465 GLU B 10 REMARK 465 ILE B 11 REMARK 465 THR B 12 REMARK 465 ILE B 13 REMARK 465 ARG B 14 REMARK 465 ASN B 15 REMARK 465 ASP B 16 REMARK 465 ASN B 17 REMARK 465 GLN B 18 REMARK 465 GLU B 19 REMARK 465 VAL B 20 REMARK 465 LEU B 21 REMARK 465 PRO B 22 REMARK 465 GLN B 23 REMARK 465 TYR B 178 REMARK 465 ASP B 179 REMARK 465 GLY B 180 REMARK 465 SER B 181 REMARK 465 ILE B 182 REMARK 465 SER B 183 REMARK 465 THR B 184 REMARK 465 ASP B 195 REMARK 465 GLN B 196 REMARK 465 PRO B 197 REMARK 465 GLY B 221 REMARK 465 GLY B 222 REMARK 465 LEU B 223 REMARK 465 GLU B 224 REMARK 465 HIS B 225 REMARK 465 PRO B 226 REMARK 465 ILE B 227 REMARK 465 ASN B 228 REMARK 465 GLU B 229 REMARK 465 ASN B 230 REMARK 465 ARG B 259 REMARK 465 MET B 260 REMARK 465 VAL B 261 REMARK 465 GLY B 270 REMARK 465 LEU B 271 REMARK 465 ASN B 272 REMARK 465 SER B 273 REMARK 465 THR B 281 REMARK 465 ILE B 282 REMARK 465 SER B 283 REMARK 465 MET B 284 REMARK 465 ARG B 285 REMARK 465 GLN B 286 REMARK 465 SER B 326 REMARK 465 ASP B 327 REMARK 465 ILE B 328 REMARK 465 SER B 455 REMARK 465 GLU D 1 REMARK 465 VAL D 2 REMARK 465 GLN D 3 REMARK 465 LEU D 4 REMARK 465 VAL D 5 REMARK 465 GLU D 6 REMARK 465 SER D 7 REMARK 465 GLY D 8 REMARK 465 GLY D 9 REMARK 465 GLY D 10 REMARK 465 VAL D 11 REMARK 465 VAL D 12 REMARK 465 GLN D 13 REMARK 465 PRO D 14 REMARK 465 GLY D 15 REMARK 465 GLY D 16 REMARK 465 SER D 17 REMARK 465 LEU D 18 REMARK 465 ARG D 19 REMARK 465 LEU D 20 REMARK 465 SER D 21 REMARK 465 CYS D 22 REMARK 465 VAL D 23 REMARK 465 ALA D 24 REMARK 465 SER D 25 REMARK 465 GLY D 26 REMARK 465 LEU D 27 REMARK 465 SER D 28 REMARK 465 ASP D 53 REMARK 465 ASN D 54 REMARK 465 GLY D 55 REMARK 465 ASP D 56 REMARK 465 THR D 69 REMARK 465 ILE D 70 REMARK 465 SER D 71 REMARK 465 ARG D 72 REMARK 465 ASP D 73 REMARK 465 ASN D 74 REMARK 465 ALA D 75 REMARK 465 LYS D 76 REMARK 465 ASN D 77 REMARK 465 THR D 78 REMARK 465 LEU D 79 REMARK 465 TYR D 80 REMARK 465 LEU D 81 REMARK 465 ALA D 92 REMARK 465 VAL D 93 REMARK 465 TYR D 94 REMARK 465 PHE D 95 REMARK 465 CYS D 96 REMARK 465 GLY D 121 REMARK 465 GLN D 122 REMARK 465 GLY D 123 REMARK 465 THR D 124 REMARK 465 LEU D 125 REMARK 465 VAL D 126 REMARK 465 THR D 127 REMARK 465 VAL D 128 REMARK 465 SER D 129 REMARK 465 SER D 130 REMARK 465 ALA D 131 REMARK 465 SER D 132 REMARK 465 THR D 133 REMARK 465 LYS D 134 REMARK 465 GLY D 135 REMARK 465 PRO D 136 REMARK 465 SER D 137 REMARK 465 VAL D 138 REMARK 465 PHE D 139 REMARK 465 PRO D 140 REMARK 465 LEU D 141 REMARK 465 ALA D 142 REMARK 465 PRO D 143 REMARK 465 SER D 144 REMARK 465 SER D 145 REMARK 465 LYS D 146 REMARK 465 SER D 147 REMARK 465 THR D 148 REMARK 465 SER D 149 REMARK 465 GLY D 150 REMARK 465 GLY D 151 REMARK 465 THR D 152 REMARK 465 ALA D 153 REMARK 465 ALA D 154 REMARK 465 LEU D 155 REMARK 465 GLY D 156 REMARK 465 CYS D 157 REMARK 465 LEU D 158 REMARK 465 VAL D 159 REMARK 465 LYS D 160 REMARK 465 ASP D 161 REMARK 465 TYR D 162 REMARK 465 PHE D 163 REMARK 465 PRO D 164 REMARK 465 GLU D 165 REMARK 465 PRO D 166 REMARK 465 VAL D 167 REMARK 465 THR D 168 REMARK 465 VAL D 169 REMARK 465 SER D 170 REMARK 465 TRP D 171 REMARK 465 ASN D 172 REMARK 465 SER D 173 REMARK 465 GLY D 174 REMARK 465 ALA D 175 REMARK 465 LEU D 176 REMARK 465 THR D 177 REMARK 465 SER D 178 REMARK 465 GLY D 179 REMARK 465 VAL D 180 REMARK 465 HIS D 181 REMARK 465 THR D 182 REMARK 465 PHE D 183 REMARK 465 PRO D 184 REMARK 465 ALA D 185 REMARK 465 VAL D 186 REMARK 465 LEU D 187 REMARK 465 GLN D 188 REMARK 465 SER D 189 REMARK 465 SER D 190 REMARK 465 GLY D 191 REMARK 465 LEU D 192 REMARK 465 TYR D 193 REMARK 465 SER D 194 REMARK 465 LEU D 195 REMARK 465 SER D 196 REMARK 465 SER D 197 REMARK 465 VAL D 198 REMARK 465 VAL D 199 REMARK 465 THR D 200 REMARK 465 VAL D 201 REMARK 465 PRO D 202 REMARK 465 SER D 203 REMARK 465 SER D 204 REMARK 465 SER D 205 REMARK 465 LEU D 206 REMARK 465 GLY D 207 REMARK 465 THR D 208 REMARK 465 GLN D 209 REMARK 465 THR D 210 REMARK 465 TYR D 211 REMARK 465 ILE D 212 REMARK 465 CYS D 213 REMARK 465 ASN D 214 REMARK 465 VAL D 215 REMARK 465 ASN D 216 REMARK 465 HIS D 217 REMARK 465 LYS D 218 REMARK 465 PRO D 219 REMARK 465 SER D 220 REMARK 465 ASN D 221 REMARK 465 THR D 222 REMARK 465 LYS D 223 REMARK 465 VAL D 224 REMARK 465 ASP D 225 REMARK 465 LYS D 226 REMARK 465 ARG D 227 REMARK 465 VAL D 228 REMARK 465 GLU D 229 REMARK 465 PRO D 230 REMARK 465 LYS D 231 REMARK 465 SER D 232 REMARK 465 CYS D 233 REMARK 465 GLN F 1 REMARK 465 SER F 2 REMARK 465 VAL F 3 REMARK 465 LEU F 4 REMARK 465 THR F 5 REMARK 465 GLN F 6 REMARK 465 PRO F 7 REMARK 465 PRO F 8 REMARK 465 SER F 9 REMARK 465 ALA F 10 REMARK 465 SER F 11 REMARK 465 GLY F 12 REMARK 465 THR F 13 REMARK 465 PRO F 14 REMARK 465 GLY F 15 REMARK 465 GLN F 16 REMARK 465 GLY F 17 REMARK 465 VAL F 18 REMARK 465 THR F 19 REMARK 465 ILE F 20 REMARK 465 SER F 21 REMARK 465 CYS F 22 REMARK 465 SER F 23 REMARK 465 GLY F 24 REMARK 465 SER F 25 REMARK 465 ASN F 26 REMARK 465 SER F 27 REMARK 465 ASN F 28 REMARK 465 TYR F 36A REMARK 465 GLN F 36B REMARK 465 GLY F 65 REMARK 465 SER F 66 REMARK 465 ARG F 67 REMARK 465 SER F 68 REMARK 465 GLY F 69 REMARK 465 THR F 70 REMARK 465 SER F 71 REMARK 465 ALA F 72 REMARK 465 SER F 73 REMARK 465 LEU F 74 REMARK 465 ALA F 75 REMARK 465 ILE F 76 REMARK 465 SER F 77 REMARK 465 GLY F 78 REMARK 465 LEU F 79 REMARK 465 GLN F 80 REMARK 465 SER F 81 REMARK 465 GLU F 82 REMARK 465 ASP F 83 REMARK 465 GLU F 84 REMARK 465 ALA F 85 REMARK 465 VAL F 86 REMARK 465 GLY F 103 REMARK 465 GLY F 104 REMARK 465 GLY F 105 REMARK 465 THR F 106 REMARK 465 LYS F 107 REMARK 465 LEU F 108 REMARK 465 THR F 109 REMARK 465 VAL F 110 REMARK 465 LEU F 111 REMARK 465 ARG F 112 REMARK 465 GLN F 113 REMARK 465 PRO F 114 REMARK 465 LYS F 115 REMARK 465 ALA F 116 REMARK 465 ALA F 117 REMARK 465 PRO F 118 REMARK 465 SER F 119 REMARK 465 VAL F 120 REMARK 465 THR F 121 REMARK 465 LEU F 122 REMARK 465 PHE F 123 REMARK 465 PRO F 124 REMARK 465 PRO F 125 REMARK 465 SER F 126 REMARK 465 SER F 127 REMARK 465 GLU F 128 REMARK 465 GLU F 129 REMARK 465 LEU F 130 REMARK 465 GLN F 131 REMARK 465 ALA F 132 REMARK 465 ASN F 133 REMARK 465 LYS F 134 REMARK 465 ALA F 135 REMARK 465 THR F 136 REMARK 465 LEU F 137 REMARK 465 VAL F 138 REMARK 465 CYS F 139 REMARK 465 LEU F 140 REMARK 465 ILE F 141 REMARK 465 SER F 142 REMARK 465 ASP F 143 REMARK 465 PHE F 144 REMARK 465 TYR F 145 REMARK 465 PRO F 146 REMARK 465 GLY F 147 REMARK 465 ALA F 148 REMARK 465 VAL F 149 REMARK 465 THR F 150 REMARK 465 VAL F 151 REMARK 465 ALA F 152 REMARK 465 TRP F 153 REMARK 465 LYS F 154 REMARK 465 ALA F 155 REMARK 465 ASP F 156 REMARK 465 SER F 157 REMARK 465 SER F 158 REMARK 465 PRO F 159 REMARK 465 VAL F 160 REMARK 465 LYS F 161 REMARK 465 ALA F 162 REMARK 465 GLY F 163 REMARK 465 VAL F 164 REMARK 465 GLU F 165 REMARK 465 THR F 166 REMARK 465 THR F 167 REMARK 465 THR F 168 REMARK 465 PRO F 169 REMARK 465 SER F 170 REMARK 465 LYS F 171 REMARK 465 GLN F 172 REMARK 465 SER F 173 REMARK 465 ASN F 174 REMARK 465 ASN F 175 REMARK 465 LYS F 176 REMARK 465 TYR F 177 REMARK 465 ALA F 178 REMARK 465 ALA F 179 REMARK 465 SER F 180 REMARK 465 SER F 181 REMARK 465 TYR F 182 REMARK 465 LEU F 183 REMARK 465 SER F 184 REMARK 465 LEU F 185 REMARK 465 THR F 186 REMARK 465 PRO F 187 REMARK 465 GLU F 188 REMARK 465 GLN F 189 REMARK 465 TRP F 190 REMARK 465 LYS F 191 REMARK 465 SER F 192 REMARK 465 HIS F 193 REMARK 465 ARG F 194 REMARK 465 SER F 195 REMARK 465 TYR F 196 REMARK 465 SER F 197 REMARK 465 CYS F 198 REMARK 465 GLN F 199 REMARK 465 VAL F 200 REMARK 465 THR F 201 REMARK 465 HIS F 202 REMARK 465 GLU F 203 REMARK 465 GLY F 204 REMARK 465 SER F 205 REMARK 465 THR F 206 REMARK 465 VAL F 207 REMARK 465 GLU F 208 REMARK 465 LYS F 209 REMARK 465 THR F 210 REMARK 465 VAL F 211 REMARK 465 ALA F 212 REMARK 465 PRO F 213 REMARK 465 THR F 214 REMARK 465 GLU F 215 REMARK 465 CYS F 216 REMARK 465 SER F 217 REMARK 465 GLU H 1 REMARK 465 ASN H 115 REMARK 465 PRO H 116 REMARK 465 PRO H 121 REMARK 465 ALA H 122 REMARK 465 SER H 123 REMARK 465 THR H 124 REMARK 465 LYS H 125 REMARK 465 GLY H 126 REMARK 465 PRO H 127 REMARK 465 SER H 128 REMARK 465 VAL H 129 REMARK 465 PHE H 130 REMARK 465 PRO H 131 REMARK 465 LEU H 132 REMARK 465 ALA H 133 REMARK 465 PRO H 134 REMARK 465 SER H 135 REMARK 465 SER H 136 REMARK 465 LYS H 137 REMARK 465 SER H 138 REMARK 465 THR H 139 REMARK 465 SER H 140 REMARK 465 GLY H 141 REMARK 465 GLY H 142 REMARK 465 THR H 143 REMARK 465 ALA H 144 REMARK 465 ALA H 145 REMARK 465 LEU H 146 REMARK 465 GLY H 147 REMARK 465 CYS H 148 REMARK 465 LEU H 149 REMARK 465 VAL H 150 REMARK 465 LYS H 151 REMARK 465 ASP H 152 REMARK 465 TYR H 153 REMARK 465 PHE H 154 REMARK 465 PRO H 155 REMARK 465 GLU H 156 REMARK 465 PRO H 157 REMARK 465 VAL H 158 REMARK 465 THR H 159 REMARK 465 VAL H 160 REMARK 465 SER H 161 REMARK 465 TRP H 162 REMARK 465 ASN H 163 REMARK 465 SER H 164 REMARK 465 GLY H 165 REMARK 465 ALA H 166 REMARK 465 LEU H 167 REMARK 465 THR H 168 REMARK 465 SER H 169 REMARK 465 GLY H 170 REMARK 465 VAL H 171 REMARK 465 HIS H 172 REMARK 465 THR H 173 REMARK 465 PHE H 174 REMARK 465 PRO H 175 REMARK 465 ALA H 176 REMARK 465 VAL H 177 REMARK 465 LEU H 178 REMARK 465 GLN H 179 REMARK 465 SER H 180 REMARK 465 SER H 181 REMARK 465 GLY H 182 REMARK 465 LEU H 183 REMARK 465 TYR H 184 REMARK 465 SER H 185 REMARK 465 LEU H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 VAL H 189 REMARK 465 VAL H 190 REMARK 465 THR H 191 REMARK 465 VAL H 192 REMARK 465 PRO H 193 REMARK 465 SER H 194 REMARK 465 SER H 195 REMARK 465 SER H 196 REMARK 465 LEU H 197 REMARK 465 GLY H 198 REMARK 465 THR H 199 REMARK 465 GLN H 200 REMARK 465 THR H 201 REMARK 465 TYR H 202 REMARK 465 ILE H 203 REMARK 465 CYS H 204 REMARK 465 ASN H 205 REMARK 465 VAL H 206 REMARK 465 ASN H 207 REMARK 465 HIS H 208 REMARK 465 LYS H 209 REMARK 465 PRO H 210 REMARK 465 SER H 211 REMARK 465 ASN H 212 REMARK 465 THR H 213 REMARK 465 LYS H 214 REMARK 465 VAL H 215 REMARK 465 ASP H 216 REMARK 465 LYS H 217 REMARK 465 ARG H 218 REMARK 465 VAL H 219 REMARK 465 GLU H 220 REMARK 465 PRO H 221 REMARK 465 LYS H 222 REMARK 465 SER H 223 REMARK 465 CYS H 224 REMARK 465 ASP J 1 REMARK 465 ARG J 112 REMARK 465 THR J 113 REMARK 465 VAL J 114 REMARK 465 ALA J 115 REMARK 465 ALA J 116 REMARK 465 PRO J 117 REMARK 465 SER J 118 REMARK 465 VAL J 119 REMARK 465 PHE J 120 REMARK 465 ILE J 121 REMARK 465 PHE J 122 REMARK 465 PRO J 123 REMARK 465 PRO J 124 REMARK 465 SER J 125 REMARK 465 ASP J 126 REMARK 465 GLU J 127 REMARK 465 GLN J 128 REMARK 465 LEU J 129 REMARK 465 LYS J 130 REMARK 465 SER J 131 REMARK 465 GLY J 132 REMARK 465 THR J 133 REMARK 465 ALA J 134 REMARK 465 SER J 135 REMARK 465 VAL J 136 REMARK 465 VAL J 137 REMARK 465 CYS J 138 REMARK 465 LEU J 139 REMARK 465 LEU J 140 REMARK 465 ASN J 141 REMARK 465 ASN J 142 REMARK 465 PHE J 143 REMARK 465 TYR J 144 REMARK 465 PRO J 145 REMARK 465 ARG J 146 REMARK 465 GLU J 147 REMARK 465 ALA J 148 REMARK 465 LYS J 149 REMARK 465 VAL J 150 REMARK 465 GLN J 151 REMARK 465 TRP J 152 REMARK 465 LYS J 153 REMARK 465 VAL J 154 REMARK 465 ASP J 155 REMARK 465 ASN J 156 REMARK 465 ALA J 157 REMARK 465 LEU J 158 REMARK 465 GLN J 159 REMARK 465 SER J 160 REMARK 465 GLY J 161 REMARK 465 ASN J 162 REMARK 465 SER J 163 REMARK 465 GLN J 164 REMARK 465 GLU J 165 REMARK 465 SER J 166 REMARK 465 VAL J 167 REMARK 465 THR J 168 REMARK 465 GLU J 169 REMARK 465 GLN J 170 REMARK 465 ASP J 171 REMARK 465 SER J 172 REMARK 465 LYS J 173 REMARK 465 ASP J 174 REMARK 465 SER J 175 REMARK 465 THR J 176 REMARK 465 TYR J 177 REMARK 465 SER J 178 REMARK 465 LEU J 179 REMARK 465 SER J 180 REMARK 465 SER J 181 REMARK 465 THR J 182 REMARK 465 LEU J 183 REMARK 465 THR J 184 REMARK 465 LEU J 185 REMARK 465 SER J 186 REMARK 465 LYS J 187 REMARK 465 ALA J 188 REMARK 465 ASP J 189 REMARK 465 TYR J 190 REMARK 465 GLU J 191 REMARK 465 LYS J 192 REMARK 465 HIS J 193 REMARK 465 LYS J 194 REMARK 465 VAL J 195 REMARK 465 TYR J 196 REMARK 465 ALA J 197 REMARK 465 CYS J 198 REMARK 465 GLU J 199 REMARK 465 VAL J 200 REMARK 465 THR J 201 REMARK 465 HIS J 202 REMARK 465 GLN J 203 REMARK 465 GLY J 204 REMARK 465 LEU J 205 REMARK 465 SER J 206 REMARK 465 SER J 207 REMARK 465 PRO J 208 REMARK 465 VAL J 209 REMARK 465 THR J 210 REMARK 465 LYS J 211 REMARK 465 SER J 212 REMARK 465 PHE J 213 REMARK 465 ASN J 214 REMARK 465 ARG J 215 REMARK 465 GLY J 216 REMARK 465 GLU J 217 REMARK 465 CYS J 218 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS A 32 CE NZ REMARK 470 ASN A 35 CG OD1 ND2 REMARK 470 ASP A 37 CG OD1 OD2 REMARK 470 ARG A 41 CG CD NE CZ NH1 NH2 REMARK 470 LEU A 46 CG CD1 CD2 REMARK 470 LYS A 51 CG CD CE NZ REMARK 470 LYS A 54 CG CD CE NZ REMARK 470 ARG A 56 CG CD NE CZ NH1 NH2 REMARK 470 ASP A 83 CG OD1 OD2 REMARK 470 LEU A 84 CG CD1 CD2 REMARK 470 ILE A 85 CG1 CG2 CD1 REMARK 470 ARG A 95 CG CD NE CZ NH1 NH2 REMARK 470 GLN A 98 CG CD OE1 NE2 REMARK 470 ASP A 99 CG OD1 OD2 REMARK 470 ILE A 100 CG1 CG2 CD1 REMARK 470 LYS A 102 CG CD CE NZ REMARK 470 ASP A 117 CG OD1 OD2 REMARK 470 ARG A 125 CG CD NE CZ NH1 NH2 REMARK 470 ASN A 133 CG OD1 ND2 REMARK 470 LYS A 137 CE NZ REMARK 470 ASN A 145 CG OD1 ND2 REMARK 470 ASP A 147 CG OD1 OD2 REMARK 470 LYS A 156 CG CD CE NZ REMARK 470 GLU A 159 CG CD OE1 OE2 REMARK 470 ARG A 160 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 188 CG CD CE NZ REMARK 470 ILE A 192 CG1 CG2 CD1 REMARK 470 PHE A 194 CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU A 201 CG CD1 CD2 REMARK 470 LEU A 218 CG CD1 CD2 REMARK 470 LYS A 241 CG CD CE NZ REMARK 470 ARG A 244 CG CD NE CZ NH1 NH2 REMARK 470 GLN A 248 CG CD OE1 NE2 REMARK 470 ASN A 262 CG OD1 ND2 REMARK 470 ASP A 268 CG OD1 OD2 REMARK 470 LYS A 269 CD CE NZ REMARK 470 LYS A 276 CG CD CE NZ REMARK 470 LYS A 278 CG CD CE NZ REMARK 470 ASN A 287 CG OD1 ND2 REMARK 470 TYR A 288 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LYS A 301 CG CD CE NZ REMARK 470 ARG A 307 NE CZ NH1 NH2 REMARK 470 SER A 310 OG REMARK 470 HIS A 312 CG ND1 CD2 CE1 NE2 REMARK 470 LYS A 314 CG CD CE NZ REMARK 470 GLN A 316 CG CD OE1 NE2 REMARK 470 ASP A 321 CG OD1 OD2 REMARK 470 THR A 323 OG1 CG2 REMARK 470 ASP A 324 CG OD1 OD2 REMARK 470 ARG A 329 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 331 CG CD CE NZ REMARK 470 GLU A 345 CG CD OE1 OE2 REMARK 470 ILE A 357 CG1 CG2 CD1 REMARK 470 ASN A 368 CG OD1 ND2 REMARK 470 ASP A 380 CG OD1 OD2 REMARK 470 GLN A 382 CG CD OE1 NE2 REMARK 470 LYS A 383 CG CD CE NZ REMARK 470 THR A 391 OG1 CG2 REMARK 470 GLU A 397 CG CD OE1 OE2 REMARK 470 ARG A 398 CG CD NE CZ NH1 NH2 REMARK 470 GLU A 401 CG CD OE1 OE2 REMARK 470 ARG A 407 CG CD NE CZ NH1 NH2 REMARK 470 THR A 414 OG1 CG2 REMARK 470 THR A 415 OG1 CG2 REMARK 470 THR A 416 OG1 CG2 REMARK 470 SER A 417 OG REMARK 470 GLU A 432 CG CD OE1 OE2 REMARK 470 LYS A 436 CG CD CE NZ REMARK 470 LEU A 438 CG CD1 CD2 REMARK 470 ASN A 439 CG OD1 ND2 REMARK 470 THR A 440 OG1 CG2 REMARK 470 GLN A 442 CG CD OE1 NE2 REMARK 470 GLU A 449 CG CD OE1 OE2 REMARK 470 LYS A 452 CG CD CE NZ REMARK 470 SER A 453 OG REMARK 470 SER C 30 OG REMARK 470 ASN C 32 CG OD1 ND2 REMARK 470 GLN C 39 CG CD OE1 NE2 REMARK 470 LYS C 43 CG CD CE NZ REMARK 470 LEU C 45 CG CD1 CD2 REMARK 470 TRP C 47 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP C 47 CZ3 CH2 REMARK 470 ILE C 51 CG1 CG2 CD1 REMARK 470 ASP C 56 CG OD1 OD2 REMARK 470 THR C 58 OG1 CG2 REMARK 470 VAL C 64 CG1 CG2 REMARK 470 MET C 65 CG SD CE REMARK 470 ARG C 67 CG CD NE CZ NH1 NH2 REMARK 470 PHE C 68 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLN C 82 CG CD OE1 NE2 REMARK 470 MET C 83 CG SD CE REMARK 470 ASN C 84 CG OD1 ND2 REMARK 470 ASN C 85 CG OD1 ND2 REMARK 470 ARG C 87 CG CD NE CZ NH1 NH2 REMARK 470 ASP C 89 CG OD1 OD2 REMARK 470 VAL C 97 CG1 CG2 REMARK 470 ARG C 98 CG CD NE CZ NH1 NH2 REMARK 470 GLU C 99 CG CD OE1 OE2 REMARK 470 ASP C 118 CG OD1 OD2 REMARK 470 THR E 31 OG1 CG2 REMARK 470 VAL E 34 CG1 CG2 REMARK 470 ASP E 35 CG OD1 OD2 REMARK 470 TRP E 36 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP E 36 CZ3 CH2 REMARK 470 PHE E 40 CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR E 43 OG1 CG2 REMARK 470 ARG E 46 CG CD NE CZ NH1 NH2 REMARK 470 LEU E 47 CG CD1 CD2 REMARK 470 LEU E 48 CG CD1 CD2 REMARK 470 ILE E 49 CG1 CG2 CD1 REMARK 470 PHE E 50 CG CD1 CD2 CE1 CE2 CZ REMARK 470 ASN E 51 CG OD1 ND2 REMARK 470 ASP E 52 CG OD1 OD2 REMARK 470 ASN E 53 CG OD1 ND2 REMARK 470 GLN E 54 CG CD OE1 NE2 REMARK 470 ARG E 55 CG CD NE CZ NH1 NH2 REMARK 470 SER E 57 OG REMARK 470 ASP E 61 CG OD1 OD2 REMARK 470 PHE E 63 CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR E 91 OG1 CG2 REMARK 470 ASP E 93 CG OD1 OD2 REMARK 470 ASP E 94 CG OD1 OD2 REMARK 470 SER E 95 OG REMARK 470 LEU E 96 CG CD1 CD2 REMARK 470 ASN E 97 CG OD1 ND2 REMARK 470 PRO E 99 CG CD REMARK 470 VAL E 100 CG1 CG2 REMARK 470 GLN G 13 CG CD OE1 NE2 REMARK 470 SER G 21 OG REMARK 470 SER G 25 OG REMARK 470 SER G 28 OG REMARK 470 SER G 30 OG REMARK 470 SER G 31 OG REMARK 470 GLN G 39 CG CD OE1 NE2 REMARK 470 LYS G 43 CG CD CE NZ REMARK 470 ASP G 62 CG OD1 OD2 REMARK 470 ASP G 73 CG OD1 OD2 REMARK 470 ASN G 74 CG OD1 ND2 REMARK 470 LYS G 76 CG CD CE NZ REMARK 470 ASP G 77 CG OD1 OD2 REMARK 470 MET G 83 CG SD CE REMARK 470 SER G 85 OG REMARK 470 GLU G 89 CG CD OE1 OE2 REMARK 470 ARG G 101 CG CD NE CZ NH1 NH2 REMARK 470 ASP G 103 CG OD1 OD2 REMARK 470 ASP G 109 CG OD1 OD2 REMARK 470 SER G 120 OG REMARK 470 VAL I 3 CG1 CG2 REMARK 470 SER I 7 OG REMARK 470 LEU I 9 CG CD1 CD2 REMARK 470 SER I 10 OG REMARK 470 THR I 14 OG1 CG2 REMARK 470 GLU I 17 CG CD OE1 OE2 REMARK 470 SER I 20 OG REMARK 470 SER I 22 OG REMARK 470 ARG I 24 CG CD NE CZ NH1 NH2 REMARK 470 GLN I 27 CG CD OE1 NE2 REMARK 470 ASP I 39 CG OD1 OD2 REMARK 470 LEU I 42 CG CD1 CD2 REMARK 470 LYS I 44 CG CD CE NZ REMARK 470 SER I 48 OG REMARK 470 LEU I 51 CG CD1 CD2 REMARK 470 SER I 57 OG REMARK 470 ARG I 59 CG CD NE CZ NH1 NH2 REMARK 470 SER I 61 OG REMARK 470 ASP I 65 CG OD1 OD2 REMARK 470 SER I 68 OG REMARK 470 SER I 72 OG REMARK 470 SER I 74 OG REMARK 470 ASP I 75 CG OD1 OD2 REMARK 470 SER I 81 OG REMARK 470 ARG I 82 CG CD NE CZ NH1 NH2 REMARK 470 GLU I 84 CG CD OE1 OE2 REMARK 470 GLU I 86 CG CD OE1 OE2 REMARK 470 ASP I 87 CG OD1 OD2 REMARK 470 VAL I 88 CG1 CG2 REMARK 470 GLN I 104 CG CD OE1 NE2 REMARK 470 LYS I 107 CG CD CE NZ REMARK 470 GLU I 109 CG CD OE1 OE2 REMARK 470 LYS I 111 CG CD CE NZ REMARK 470 LYS B 32 CE NZ REMARK 470 ASN B 35 CG OD1 ND2 REMARK 470 ASP B 37 CG OD1 OD2 REMARK 470 ARG B 41 CG CD NE CZ NH1 NH2 REMARK 470 LEU B 46 CG CD1 CD2 REMARK 470 LYS B 51 CG CD CE NZ REMARK 470 LYS B 54 CG CD CE NZ REMARK 470 ARG B 56 CG CD NE CZ NH1 NH2 REMARK 470 ASP B 83 CG OD1 OD2 REMARK 470 LEU B 84 CG CD1 CD2 REMARK 470 ILE B 85 CG1 CG2 CD1 REMARK 470 ARG B 95 CG CD NE CZ NH1 NH2 REMARK 470 GLN B 98 CG CD OE1 NE2 REMARK 470 ASP B 99 CG OD1 OD2 REMARK 470 ILE B 100 CG1 CG2 CD1 REMARK 470 LYS B 102 CG CD CE NZ REMARK 470 ASP B 117 CG OD1 OD2 REMARK 470 ARG B 125 CG CD NE CZ NH1 NH2 REMARK 470 ASN B 133 CG OD1 ND2 REMARK 470 LYS B 137 CE NZ REMARK 470 ASN B 145 CG OD1 ND2 REMARK 470 ASP B 147 CG OD1 OD2 REMARK 470 LYS B 156 CG CD CE NZ REMARK 470 GLU B 159 CG CD OE1 OE2 REMARK 470 ARG B 160 CG CD NE CZ NH1 NH2 REMARK 470 LYS B 188 CG CD CE NZ REMARK 470 ILE B 192 CG1 CG2 CD1 REMARK 470 PHE B 194 CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU B 201 CG CD1 CD2 REMARK 470 LEU B 218 CG CD1 CD2 REMARK 470 LYS B 241 CG CD CE NZ REMARK 470 ARG B 244 CG CD NE CZ NH1 NH2 REMARK 470 GLN B 248 CG CD OE1 NE2 REMARK 470 ASN B 262 CG OD1 ND2 REMARK 470 ASP B 268 CG OD1 OD2 REMARK 470 LYS B 269 CD CE NZ REMARK 470 LYS B 276 CG CD CE NZ REMARK 470 LYS B 278 CG CD CE NZ REMARK 470 ASN B 287 CG OD1 ND2 REMARK 470 TYR B 288 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LYS B 301 CG CD CE NZ REMARK 470 ARG B 307 NE CZ NH1 NH2 REMARK 470 SER B 310 OG REMARK 470 HIS B 312 CG ND1 CD2 CE1 NE2 REMARK 470 LYS B 314 CG CD CE NZ REMARK 470 GLN B 316 CG CD OE1 NE2 REMARK 470 ASP B 321 CG OD1 OD2 REMARK 470 THR B 323 OG1 CG2 REMARK 470 ASP B 324 CG OD1 OD2 REMARK 470 ARG B 329 CG CD NE CZ NH1 NH2 REMARK 470 LYS B 331 CG CD CE NZ REMARK 470 GLU B 345 CG CD OE1 OE2 REMARK 470 ILE B 357 CG1 CG2 CD1 REMARK 470 ASN B 368 CG OD1 ND2 REMARK 470 ASP B 380 CG OD1 OD2 REMARK 470 GLN B 382 CG CD OE1 NE2 REMARK 470 LYS B 383 CG CD CE NZ REMARK 470 THR B 391 OG1 CG2 REMARK 470 GLU B 397 CG CD OE1 OE2 REMARK 470 ARG B 398 CG CD NE CZ NH1 NH2 REMARK 470 GLU B 401 CG CD OE1 OE2 REMARK 470 ARG B 407 CG CD NE CZ NH1 NH2 REMARK 470 THR B 414 OG1 CG2 REMARK 470 THR B 415 OG1 CG2 REMARK 470 THR B 416 OG1 CG2 REMARK 470 SER B 417 OG REMARK 470 GLU B 432 CG CD OE1 OE2 REMARK 470 LYS B 436 CG CD CE NZ REMARK 470 LEU B 438 CG CD1 CD2 REMARK 470 ASN B 439 CG OD1 ND2 REMARK 470 THR B 440 OG1 CG2 REMARK 470 GLN B 442 CG CD OE1 NE2 REMARK 470 GLU B 449 CG CD OE1 OE2 REMARK 470 LYS B 452 CG CD CE NZ REMARK 470 SER B 453 OG REMARK 470 SER D 30 OG REMARK 470 ASN D 32 CG OD1 ND2 REMARK 470 GLN D 39 CG CD OE1 NE2 REMARK 470 LYS D 43 CG CD CE NZ REMARK 470 LEU D 45 CG CD1 CD2 REMARK 470 TRP D 47 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP D 47 CZ3 CH2 REMARK 470 ILE D 51 CG1 CG2 CD1 REMARK 470 THR D 58 OG1 CG2 REMARK 470 VAL D 64 CG1 CG2 REMARK 470 MET D 65 CG SD CE REMARK 470 ARG D 67 CG CD NE CZ NH1 NH2 REMARK 470 PHE D 68 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLN D 82 CG CD OE1 NE2 REMARK 470 MET D 83 CG SD CE REMARK 470 ASN D 84 CG OD1 ND2 REMARK 470 ASN D 85 CG OD1 ND2 REMARK 470 ARG D 87 CG CD NE CZ NH1 NH2 REMARK 470 ASP D 89 CG OD1 OD2 REMARK 470 VAL D 97 CG1 CG2 REMARK 470 ARG D 98 CG CD NE CZ NH1 NH2 REMARK 470 GLU D 99 CG CD OE1 OE2 REMARK 470 ASP D 118 CG OD1 OD2 REMARK 470 THR F 31 OG1 CG2 REMARK 470 VAL F 34 CG1 CG2 REMARK 470 ASP F 35 CG OD1 OD2 REMARK 470 PHE F 40 CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR F 43 OG1 CG2 REMARK 470 ARG F 46 CG CD NE CZ NH1 NH2 REMARK 470 LEU F 47 CG CD1 CD2 REMARK 470 LEU F 48 CG CD1 CD2 REMARK 470 ILE F 49 CG1 CG2 CD1 REMARK 470 PHE F 50 CG CD1 CD2 CE1 CE2 CZ REMARK 470 ASN F 51 CG OD1 ND2 REMARK 470 ASP F 52 CG OD1 OD2 REMARK 470 ASN F 53 CG OD1 ND2 REMARK 470 GLN F 54 CG CD OE1 NE2 REMARK 470 ARG F 55 CG CD NE CZ NH1 NH2 REMARK 470 SER F 57 OG REMARK 470 ASP F 61 CG OD1 OD2 REMARK 470 PHE F 63 CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR F 91 OG1 CG2 REMARK 470 ASP F 93 CG OD1 OD2 REMARK 470 ASP F 94 CG OD1 OD2 REMARK 470 SER F 95 OG REMARK 470 LEU F 96 CG CD1 CD2 REMARK 470 ASN F 97 CG OD1 ND2 REMARK 470 PRO F 99 CG CD REMARK 470 VAL F 100 CG1 CG2 REMARK 470 GLN H 13 CG CD OE1 NE2 REMARK 470 SER H 21 OG REMARK 470 SER H 25 OG REMARK 470 SER H 28 OG REMARK 470 SER H 30 OG REMARK 470 SER H 31 OG REMARK 470 GLN H 39 CG CD OE1 NE2 REMARK 470 LYS H 43 CG CD CE NZ REMARK 470 ASP H 62 CG OD1 OD2 REMARK 470 ASP H 73 CG OD1 OD2 REMARK 470 ASN H 74 CG OD1 ND2 REMARK 470 LYS H 76 CG CD CE NZ REMARK 470 ASP H 77 CG OD1 OD2 REMARK 470 MET H 83 CG SD CE REMARK 470 SER H 85 OG REMARK 470 GLU H 89 CG CD OE1 OE2 REMARK 470 ARG H 101 CG CD NE CZ NH1 NH2 REMARK 470 ASP H 103 CG OD1 OD2 REMARK 470 ASP H 109 CG OD1 OD2 REMARK 470 SER H 120 OG REMARK 470 VAL J 3 CG1 CG2 REMARK 470 SER J 7 OG REMARK 470 LEU J 9 CG CD1 CD2 REMARK 470 SER J 10 OG REMARK 470 THR J 14 OG1 CG2 REMARK 470 GLU J 17 CG CD OE1 OE2 REMARK 470 SER J 20 OG REMARK 470 SER J 22 OG REMARK 470 ARG J 24 CG CD NE CZ NH1 NH2 REMARK 470 GLN J 27 CG CD OE1 NE2 REMARK 470 ARG J 30 CG CD NE CZ NH1 NH2 REMARK 470 ASP J 39 CG OD1 OD2 REMARK 470 LEU J 42 CG CD1 CD2 REMARK 470 LYS J 44 CG CD CE NZ REMARK 470 SER J 48 OG REMARK 470 LEU J 51 CG CD1 CD2 REMARK 470 SER J 57 OG REMARK 470 ARG J 59 CG CD NE CZ NH1 NH2 REMARK 470 SER J 61 OG REMARK 470 ASP J 65 CG OD1 OD2 REMARK 470 SER J 68 OG REMARK 470 SER J 72 OG REMARK 470 SER J 74 OG REMARK 470 ASP J 75 CG OD1 OD2 REMARK 470 SER J 81 OG REMARK 470 ARG J 82 CG CD NE CZ NH1 NH2 REMARK 470 GLU J 84 CG CD OE1 OE2 REMARK 470 GLU J 86 CG CD OE1 OE2 REMARK 470 ASP J 87 CG OD1 OD2 REMARK 470 VAL J 88 CG1 CG2 REMARK 470 GLN J 104 CG CD OE1 NE2 REMARK 470 LYS J 107 CG CD CE NZ REMARK 470 GLU J 109 CG CD OE1 OE2 REMARK 470 LYS J 111 CG CD CE NZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 HIS A 27 -177.29 -68.90 REMARK 500 LEU A 63 52.50 -103.15 REMARK 500 ASN A 82 -165.43 -123.34 REMARK 500 LEU A 107 72.66 -100.35 REMARK 500 ASN A 145 -109.99 54.20 REMARK 500 VAL A 205 -56.89 68.80 REMARK 500 SER A 310 -154.97 -115.58 REMARK 500 SER A 339 -156.64 -152.28 REMARK 500 ASN A 343 -164.55 -116.22 REMARK 500 PRO A 347 -175.89 -68.94 REMARK 500 THR A 358 -150.56 -158.63 REMARK 500 SER A 372 -100.63 17.22 REMARK 500 LEU A 405 -90.13 -142.06 REMARK 500 TYR A 422 -112.13 52.85 REMARK 500 ALA C 88 -96.11 57.52 REMARK 500 ASP C 90 -36.91 -132.53 REMARK 500 ALA C 114 -179.31 -69.34 REMARK 500 PRO C 119 -158.70 -85.93 REMARK 500 ASP E 52 -5.99 67.62 REMARK 500 ASN E 53 -37.80 -131.54 REMARK 500 VAL G 48 -61.25 -99.33 REMARK 500 LEU I 52 -63.66 -100.14 REMARK 500 ALA I 96 -0.43 -147.76 REMARK 500 GLN I 98 -168.74 -115.87 REMARK 500 LEU B 63 53.01 -102.32 REMARK 500 ASN B 82 -164.85 -122.73 REMARK 500 ASN B 145 -109.99 54.68 REMARK 500 VAL B 205 -57.23 69.36 REMARK 500 ASP B 257 17.83 52.50 REMARK 500 SER B 310 -154.23 -115.40 REMARK 500 SER B 339 -156.29 -152.14 REMARK 500 ASN B 343 -163.92 -116.56 REMARK 500 PRO B 347 -175.47 -69.74 REMARK 500 THR B 358 -151.08 -158.71 REMARK 500 SER B 372 -99.86 15.70 REMARK 500 LEU B 405 -89.94 -142.36 REMARK 500 TYR B 422 -110.02 52.34 REMARK 500 THR D 58 55.52 39.30 REMARK 500 ALA D 88 -96.40 57.24 REMARK 500 ASP D 90 -38.92 -136.53 REMARK 500 ASP F 52 -7.56 67.65 REMARK 500 ASN F 53 -38.25 -131.52 REMARK 500 ASP H 109 -61.00 -90.51 REMARK 500 SER J 28 124.59 -39.24 REMARK 500 LEU J 52 -63.43 -100.11 REMARK 500 GLN J 98 -168.57 -116.07 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG A 258 0.29 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-47333 RELATED DB: EMDB REMARK 900 CRYOEM STRUCTURE OF THE HUMAN ANTIBODIES PIV3HN-05 AND PIV3HN-13 IN REMARK 900 COMPLEX WITH THE PARAINFLUENZA VIRUS HEMAGGLUTININ-NEURAMINIDASE REMARK 900 PROTEIN DBREF 9DZQ A 8 455 UNP Q81080 Q81080_9MONO 125 572 DBREF 9DZQ C 1 233 PDB 9DZQ 9DZQ 1 233 DBREF 9DZQ E 1 217 PDB 9DZQ 9DZQ 1 217 DBREF 9DZQ G 1 224 PDB 9DZQ 9DZQ 1 224 DBREF 9DZQ I 1 218 PDB 9DZQ 9DZQ 1 218 DBREF 9DZQ B 8 455 UNP Q81080 Q81080_9MONO 125 572 DBREF 9DZQ D 1 233 PDB 9DZQ 9DZQ 1 233 DBREF 9DZQ F 1 217 PDB 9DZQ 9DZQ 1 217 DBREF 9DZQ H 1 224 PDB 9DZQ 9DZQ 1 224 DBREF 9DZQ J 1 218 PDB 9DZQ 9DZQ 1 218 SEQADV 9DZQ HIS A -5 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS A -4 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS A -3 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS A -2 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS A -1 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS A 0 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ SER A 1 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ LEU A 2 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ VAL A 3 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ PRO A 4 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ ARG A 5 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ GLY A 6 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ SER A 7 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS B -5 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS B -4 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS B -3 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS B -2 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS B -1 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ HIS B 0 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ SER B 1 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ LEU B 2 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ VAL B 3 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ PRO B 4 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ ARG B 5 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ GLY B 6 UNP Q81080 EXPRESSION TAG SEQADV 9DZQ SER B 7 UNP Q81080 EXPRESSION TAG SEQRES 1 A 461 HIS HIS HIS HIS HIS HIS SER LEU VAL PRO ARG GLY SER SEQRES 2 A 461 ILE SER GLU ILE THR ILE ARG ASN ASP ASN GLN GLU VAL SEQRES 3 A 461 LEU PRO GLN ARG ILE THR HIS ASP VAL GLY ILE LYS PRO SEQRES 4 A 461 LEU ASN PRO ASP ASP PHE TRP ARG CYS THR SER GLY LEU SEQRES 5 A 461 PRO SER LEU MET LYS THR PRO LYS ILE ARG LEU MET PRO SEQRES 6 A 461 GLY PRO GLY LEU LEU ALA MET PRO THR THR VAL ASP GLY SEQRES 7 A 461 CYS VAL ARG THR PRO SER LEU VAL ILE ASN ASP LEU ILE SEQRES 8 A 461 TYR ALA TYR THR SER ASN LEU ILE THR ARG GLY CYS GLN SEQRES 9 A 461 ASP ILE GLY LYS SER TYR GLN VAL LEU GLN ILE GLY ILE SEQRES 10 A 461 ILE THR VAL ASN SER ASP LEU VAL PRO ASP LEU ASN PRO SEQRES 11 A 461 ARG ILE SER HIS THR PHE ASN ILE ASN ASP ASN ARG LYS SEQRES 12 A 461 SER CYS SER LEU ALA LEU LEU ASN THR ASP VAL TYR GLN SEQRES 13 A 461 LEU CYS SER THR PRO LYS VAL ASP GLU ARG SER ASP TYR SEQRES 14 A 461 ALA SER SER GLY ILE GLU ASP ILE VAL LEU ASP ILE VAL SEQRES 15 A 461 ASN TYR ASP GLY SER ILE SER THR THR ARG PHE LYS ASN SEQRES 16 A 461 ASN ASN ILE SER PHE ASP GLN PRO TYR ALA ALA LEU TYR SEQRES 17 A 461 PRO SER VAL GLY PRO GLY ILE TYR TYR LYS GLY LYS ILE SEQRES 18 A 461 ILE PHE LEU GLY TYR GLY GLY LEU GLU HIS PRO ILE ASN SEQRES 19 A 461 GLU ASN VAL ILE CYS ASN THR THR GLY CYS PRO GLY LYS SEQRES 20 A 461 THR GLN ARG ASP CYS ASN GLN ALA SER HIS SER PRO TRP SEQRES 21 A 461 PHE SER ASP ARG ARG MET VAL ASN SER ILE ILE VAL ALA SEQRES 22 A 461 ASP LYS GLY LEU ASN SER ILE PRO LYS LEU LYS VAL TRP SEQRES 23 A 461 THR ILE SER MET ARG GLN ASN TYR TRP GLY SER GLU GLY SEQRES 24 A 461 ARG LEU LEU LEU LEU GLY ASN LYS ILE TYR ILE TYR THR SEQRES 25 A 461 ARG SER THR SER TRP HIS SER LYS LEU GLN LEU GLY ILE SEQRES 26 A 461 ILE ASP ILE THR ASP TYR SER ASP ILE ARG ILE LYS TRP SEQRES 27 A 461 THR TRP HIS ASN VAL LEU SER ARG PRO GLY ASN ASN GLU SEQRES 28 A 461 CYS PRO TRP GLY HIS SER CYS PRO ASP GLY CYS ILE THR SEQRES 29 A 461 GLY VAL TYR THR ASP ALA TYR PRO LEU ASN PRO THR GLY SEQRES 30 A 461 SER ILE VAL SER SER VAL ILE LEU ASP SER GLN LYS SER SEQRES 31 A 461 ARG VAL ASN PRO VAL ILE THR TYR SER THR ALA THR GLU SEQRES 32 A 461 ARG VAL ASN GLU LEU ALA ILE LEU ASN ARG THR LEU SER SEQRES 33 A 461 ALA GLY TYR THR THR THR SER CYS ILE THR HIS TYR ASN SEQRES 34 A 461 LYS GLY TYR CYS PHE HIS ILE VAL GLU ILE ASN HIS LYS SEQRES 35 A 461 SER LEU ASN THR PHE GLN PRO MET LEU PHE LYS THR GLU SEQRES 36 A 461 ILE PRO LYS SER CYS SER SEQRES 1 C 233 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 C 233 PRO GLY GLY SER LEU ARG LEU SER CYS VAL ALA SER GLY SEQRES 3 C 233 LEU SER LEU SER PRO ASN TRP MET HIS TRP VAL ARG GLN SEQRES 4 C 233 ALA PRO GLY LYS GLY LEU VAL TRP VAL SER ARG ILE SER SEQRES 5 C 233 ASP ASN GLY ASP THR THR ASN TYR ALA GLY SER VAL MET SEQRES 6 C 233 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN THR SEQRES 7 C 233 LEU TYR LEU GLN MET ASN ASN LEU ARG ALA ASP ASP THR SEQRES 8 C 233 ALA VAL TYR PHE CYS VAL ARG GLU SER ALA VAL ILE SER SEQRES 9 C 233 SER PRO SER TRP GLY LEU TYR ASP THR ALA TYR HIS PHE SEQRES 10 C 233 ASP PRO TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 11 C 233 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 C 233 SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY SEQRES 13 C 233 CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SEQRES 14 C 233 SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR SEQRES 15 C 233 PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SEQRES 16 C 233 SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR SEQRES 17 C 233 GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN SEQRES 18 C 233 THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 E 217 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2 E 217 PRO GLY GLN GLY VAL THR ILE SER CYS SER GLY SER ASN SEQRES 3 E 217 SER ASN ILE GLY THR ASN ALA VAL ASP TRP TYR GLN GLN SEQRES 4 E 217 PHE PRO GLY THR ALA PRO ARG LEU LEU ILE PHE ASN ASP SEQRES 5 E 217 ASN GLN ARG PRO SER GLY VAL PRO ASP ARG PHE SER GLY SEQRES 6 E 217 SER ARG SER GLY THR SER ALA SER LEU ALA ILE SER GLY SEQRES 7 E 217 LEU GLN SER GLU ASP GLU ALA VAL TYR TYR CYS ALA THR SEQRES 8 E 217 TRP ASP ASP SER LEU ASN GLY PRO VAL VAL PHE GLY GLY SEQRES 9 E 217 GLY THR LYS LEU THR VAL LEU ARG GLN PRO LYS ALA ALA SEQRES 10 E 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 E 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 E 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 E 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 E 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 E 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 E 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 E 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 G 224 GLU VAL GLN LEU LEU GLU SER GLY GLY ALA LEU VAL GLN SEQRES 2 G 224 PRO GLY GLY SER LEU ARG VAL SER CYS ALA ALA SER GLY SEQRES 3 G 224 PHE SER PHE SER SER TYR ALA MET SER TRP LEU ARG GLN SEQRES 4 G 224 THR PRO GLY LYS GLY LEU GLU TRP VAL SER ALA ILE GLY SEQRES 5 G 224 GLY SER GLY HIS SER THR TYR TYR ALA ASP SER VAL GLN SEQRES 6 G 224 GLY ARG PHE THR VAL SER ARG ASP ASN SER LYS ASP THR SEQRES 7 G 224 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 G 224 ALA VAL TYR TYR CYS ALA LYS PHE PHE ARG SER ASP GLY SEQRES 9 G 224 VAL PHE HIS PHE ASP TYR TRP GLY PRO GLY ASN PRO GLY SEQRES 10 G 224 SER PRO SER PRO ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 G 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 G 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 G 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 G 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 G 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 G 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 G 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 G 224 LYS SER CYS SEQRES 1 I 218 ASP ILE VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 I 218 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 I 218 GLN SER LEU ARG HIS SER ASP GLY ASN ASN TYR LEU ASP SEQRES 4 I 218 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 I 218 ILE TYR LEU GLY SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 I 218 ARG PHE SER GLY SER GLY SER GLY SER ASP PHE THR LEU SEQRES 7 I 218 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 I 218 TYR CYS MET GLN ALA LEU GLN THR PRO THR PHE GLY GLN SEQRES 9 I 218 GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SEQRES 10 I 218 SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SEQRES 11 I 218 SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE SEQRES 12 I 218 TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN SEQRES 13 I 218 ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU SEQRES 14 I 218 GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER THR SEQRES 15 I 218 LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL SEQRES 16 I 218 TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO SEQRES 17 I 218 VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 B 461 HIS HIS HIS HIS HIS HIS SER LEU VAL PRO ARG GLY SER SEQRES 2 B 461 ILE SER GLU ILE THR ILE ARG ASN ASP ASN GLN GLU VAL SEQRES 3 B 461 LEU PRO GLN ARG ILE THR HIS ASP VAL GLY ILE LYS PRO SEQRES 4 B 461 LEU ASN PRO ASP ASP PHE TRP ARG CYS THR SER GLY LEU SEQRES 5 B 461 PRO SER LEU MET LYS THR PRO LYS ILE ARG LEU MET PRO SEQRES 6 B 461 GLY PRO GLY LEU LEU ALA MET PRO THR THR VAL ASP GLY SEQRES 7 B 461 CYS VAL ARG THR PRO SER LEU VAL ILE ASN ASP LEU ILE SEQRES 8 B 461 TYR ALA TYR THR SER ASN LEU ILE THR ARG GLY CYS GLN SEQRES 9 B 461 ASP ILE GLY LYS SER TYR GLN VAL LEU GLN ILE GLY ILE SEQRES 10 B 461 ILE THR VAL ASN SER ASP LEU VAL PRO ASP LEU ASN PRO SEQRES 11 B 461 ARG ILE SER HIS THR PHE ASN ILE ASN ASP ASN ARG LYS SEQRES 12 B 461 SER CYS SER LEU ALA LEU LEU ASN THR ASP VAL TYR GLN SEQRES 13 B 461 LEU CYS SER THR PRO LYS VAL ASP GLU ARG SER ASP TYR SEQRES 14 B 461 ALA SER SER GLY ILE GLU ASP ILE VAL LEU ASP ILE VAL SEQRES 15 B 461 ASN TYR ASP GLY SER ILE SER THR THR ARG PHE LYS ASN SEQRES 16 B 461 ASN ASN ILE SER PHE ASP GLN PRO TYR ALA ALA LEU TYR SEQRES 17 B 461 PRO SER VAL GLY PRO GLY ILE TYR TYR LYS GLY LYS ILE SEQRES 18 B 461 ILE PHE LEU GLY TYR GLY GLY LEU GLU HIS PRO ILE ASN SEQRES 19 B 461 GLU ASN VAL ILE CYS ASN THR THR GLY CYS PRO GLY LYS SEQRES 20 B 461 THR GLN ARG ASP CYS ASN GLN ALA SER HIS SER PRO TRP SEQRES 21 B 461 PHE SER ASP ARG ARG MET VAL ASN SER ILE ILE VAL ALA SEQRES 22 B 461 ASP LYS GLY LEU ASN SER ILE PRO LYS LEU LYS VAL TRP SEQRES 23 B 461 THR ILE SER MET ARG GLN ASN TYR TRP GLY SER GLU GLY SEQRES 24 B 461 ARG LEU LEU LEU LEU GLY ASN LYS ILE TYR ILE TYR THR SEQRES 25 B 461 ARG SER THR SER TRP HIS SER LYS LEU GLN LEU GLY ILE SEQRES 26 B 461 ILE ASP ILE THR ASP TYR SER ASP ILE ARG ILE LYS TRP SEQRES 27 B 461 THR TRP HIS ASN VAL LEU SER ARG PRO GLY ASN ASN GLU SEQRES 28 B 461 CYS PRO TRP GLY HIS SER CYS PRO ASP GLY CYS ILE THR SEQRES 29 B 461 GLY VAL TYR THR ASP ALA TYR PRO LEU ASN PRO THR GLY SEQRES 30 B 461 SER ILE VAL SER SER VAL ILE LEU ASP SER GLN LYS SER SEQRES 31 B 461 ARG VAL ASN PRO VAL ILE THR TYR SER THR ALA THR GLU SEQRES 32 B 461 ARG VAL ASN GLU LEU ALA ILE LEU ASN ARG THR LEU SER SEQRES 33 B 461 ALA GLY TYR THR THR THR SER CYS ILE THR HIS TYR ASN SEQRES 34 B 461 LYS GLY TYR CYS PHE HIS ILE VAL GLU ILE ASN HIS LYS SEQRES 35 B 461 SER LEU ASN THR PHE GLN PRO MET LEU PHE LYS THR GLU SEQRES 36 B 461 ILE PRO LYS SER CYS SER SEQRES 1 D 233 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 D 233 PRO GLY GLY SER LEU ARG LEU SER CYS VAL ALA SER GLY SEQRES 3 D 233 LEU SER LEU SER PRO ASN TRP MET HIS TRP VAL ARG GLN SEQRES 4 D 233 ALA PRO GLY LYS GLY LEU VAL TRP VAL SER ARG ILE SER SEQRES 5 D 233 ASP ASN GLY ASP THR THR ASN TYR ALA GLY SER VAL MET SEQRES 6 D 233 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN THR SEQRES 7 D 233 LEU TYR LEU GLN MET ASN ASN LEU ARG ALA ASP ASP THR SEQRES 8 D 233 ALA VAL TYR PHE CYS VAL ARG GLU SER ALA VAL ILE SER SEQRES 9 D 233 SER PRO SER TRP GLY LEU TYR ASP THR ALA TYR HIS PHE SEQRES 10 D 233 ASP PRO TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 11 D 233 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 D 233 SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY SEQRES 13 D 233 CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SEQRES 14 D 233 SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR SEQRES 15 D 233 PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SEQRES 16 D 233 SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR SEQRES 17 D 233 GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN SEQRES 18 D 233 THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 F 217 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2 F 217 PRO GLY GLN GLY VAL THR ILE SER CYS SER GLY SER ASN SEQRES 3 F 217 SER ASN ILE GLY THR ASN ALA VAL ASP TRP TYR GLN GLN SEQRES 4 F 217 PHE PRO GLY THR ALA PRO ARG LEU LEU ILE PHE ASN ASP SEQRES 5 F 217 ASN GLN ARG PRO SER GLY VAL PRO ASP ARG PHE SER GLY SEQRES 6 F 217 SER ARG SER GLY THR SER ALA SER LEU ALA ILE SER GLY SEQRES 7 F 217 LEU GLN SER GLU ASP GLU ALA VAL TYR TYR CYS ALA THR SEQRES 8 F 217 TRP ASP ASP SER LEU ASN GLY PRO VAL VAL PHE GLY GLY SEQRES 9 F 217 GLY THR LYS LEU THR VAL LEU ARG GLN PRO LYS ALA ALA SEQRES 10 F 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 F 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 F 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 F 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 F 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 F 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 F 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 F 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 H 224 GLU VAL GLN LEU LEU GLU SER GLY GLY ALA LEU VAL GLN SEQRES 2 H 224 PRO GLY GLY SER LEU ARG VAL SER CYS ALA ALA SER GLY SEQRES 3 H 224 PHE SER PHE SER SER TYR ALA MET SER TRP LEU ARG GLN SEQRES 4 H 224 THR PRO GLY LYS GLY LEU GLU TRP VAL SER ALA ILE GLY SEQRES 5 H 224 GLY SER GLY HIS SER THR TYR TYR ALA ASP SER VAL GLN SEQRES 6 H 224 GLY ARG PHE THR VAL SER ARG ASP ASN SER LYS ASP THR SEQRES 7 H 224 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 H 224 ALA VAL TYR TYR CYS ALA LYS PHE PHE ARG SER ASP GLY SEQRES 9 H 224 VAL PHE HIS PHE ASP TYR TRP GLY PRO GLY ASN PRO GLY SEQRES 10 H 224 SER PRO SER PRO ALA SER THR LYS GLY PRO SER VAL PHE SEQRES 11 H 224 PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR SEQRES 12 H 224 ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU SEQRES 13 H 224 PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER SEQRES 14 H 224 GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY SEQRES 15 H 224 LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SEQRES 16 H 224 SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS SEQRES 17 H 224 LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO SEQRES 18 H 224 LYS SER CYS SEQRES 1 J 218 ASP ILE VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 J 218 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 J 218 GLN SER LEU ARG HIS SER ASP GLY ASN ASN TYR LEU ASP SEQRES 4 J 218 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 J 218 ILE TYR LEU GLY SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 J 218 ARG PHE SER GLY SER GLY SER GLY SER ASP PHE THR LEU SEQRES 7 J 218 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 J 218 TYR CYS MET GLN ALA LEU GLN THR PRO THR PHE GLY GLN SEQRES 9 J 218 GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SEQRES 10 J 218 SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SEQRES 11 J 218 SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE SEQRES 12 J 218 TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN SEQRES 13 J 218 ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU SEQRES 14 J 218 GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER THR SEQRES 15 J 218 LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL SEQRES 16 J 218 TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO SEQRES 17 J 218 VAL THR LYS SER PHE ASN ARG GLY GLU CYS HELIX 1 AA1 ASN A 35 TRP A 40 1 6 HELIX 2 AA2 ASN A 131 ASN A 135 5 5 HELIX 3 AA3 ASP A 158 SER A 165 1 8 HELIX 4 AA4 LYS A 188 ASN A 190 5 3 HELIX 5 AA5 THR A 242 ALA A 249 1 8 HELIX 6 AA6 SER A 250 HIS A 251 5 2 HELIX 7 AA7 SER A 252 SER A 256 5 5 HELIX 8 AA8 ILE E 49 ASN E 53 5 5 HELIX 9 AA9 SER G 28 TYR G 32 5 5 HELIX 10 AB1 ARG G 87 THR G 91 5 5 HELIX 11 AB2 GLU I 84 VAL I 88 5 5 HELIX 12 AB3 ASN B 35 TRP B 40 1 6 HELIX 13 AB4 ASN B 131 ASN B 135 5 5 HELIX 14 AB5 ASP B 158 SER B 165 1 8 HELIX 15 AB6 LYS B 188 ASN B 190 5 3 HELIX 16 AB7 THR B 242 ALA B 249 1 8 HELIX 17 AB8 SER B 250 HIS B 251 5 2 HELIX 18 AB9 SER B 252 SER B 256 5 5 HELIX 19 AC1 ILE F 49 ASN F 53 5 5 HELIX 20 AC2 ARG H 87 THR H 91 5 5 HELIX 21 AC3 GLU J 84 VAL J 88 5 5 SHEET 1 AA1 4 ILE A 31 PRO A 33 0 SHEET 2 AA1 4 ALA A 411 HIS A 421 -1 O THR A 420 N LYS A 32 SHEET 3 AA1 4 LYS A 424 ASN A 434 -1 O ILE A 430 N THR A 415 SHEET 4 AA1 4 PHE A 441 GLU A 449 -1 O PHE A 446 N HIS A 429 SHEET 1 AA2 2 SER A 48 LEU A 49 0 SHEET 2 AA2 2 LYS A 452 SER A 453 -1 O SER A 453 N SER A 48 SHEET 1 AA3 2 PRO A 61 GLY A 62 0 SHEET 2 AA3 2 MET B 66 PRO B 67 -1 O MET B 66 N GLY A 62 SHEET 1 AA4 2 MET A 66 PRO A 67 0 SHEET 2 AA4 2 PRO B 61 GLY B 62 -1 O GLY B 62 N MET A 66 SHEET 1 AA5 4 CYS A 73 ILE A 81 0 SHEET 2 AA5 4 TYR A 86 ILE A 93 -1 O ILE A 93 N CYS A 73 SHEET 3 AA5 4 SER A 103 VAL A 114 -1 O TYR A 104 N LEU A 92 SHEET 4 AA5 4 PRO A 120 ILE A 126 -1 O ASN A 123 N ILE A 111 SHEET 1 AA6 4 LYS A 137 LEU A 144 0 SHEET 2 AA6 4 ASP A 147 SER A 153 -1 O TYR A 149 N ALA A 142 SHEET 3 AA6 4 ILE A 171 VAL A 176 -1 O ASP A 174 N GLN A 150 SHEET 4 AA6 4 ARG A 186 PHE A 187 -1 O PHE A 187 N ILE A 171 SHEET 1 AA7 5 ILE A 192 SER A 193 0 SHEET 2 AA7 5 LYS A 276 TRP A 280 1 O LEU A 277 N SER A 193 SHEET 3 AA7 5 SER A 263 ASP A 268 -1 N VAL A 266 O LYS A 278 SHEET 4 AA7 5 LYS A 214 TYR A 220 -1 N GLY A 219 O SER A 263 SHEET 5 AA7 5 TYR A 202 PRO A 203 -1 N TYR A 202 O TYR A 220 SHEET 1 AA8 5 ILE A 192 SER A 193 0 SHEET 2 AA8 5 LYS A 276 TRP A 280 1 O LEU A 277 N SER A 193 SHEET 3 AA8 5 SER A 263 ASP A 268 -1 N VAL A 266 O LYS A 278 SHEET 4 AA8 5 LYS A 214 TYR A 220 -1 N GLY A 219 O SER A 263 SHEET 5 AA8 5 ILE A 209 TYR A 211 -1 N TYR A 211 O LYS A 214 SHEET 1 AA9 4 GLY A 293 LEU A 298 0 SHEET 2 AA9 4 LYS A 301 THR A 306 -1 O TYR A 303 N LEU A 296 SHEET 3 AA9 4 GLN A 316 ILE A 320 -1 O GLY A 318 N ILE A 304 SHEET 4 AA9 4 ILE A 330 THR A 333 -1 O LYS A 331 N ILE A 319 SHEET 1 AB1 4 ALA A 364 ASN A 368 0 SHEET 2 AB1 4 GLY A 371 LEU A 379 -1 O SER A 375 N TYR A 365 SHEET 3 AB1 4 PRO A 388 SER A 393 -1 O SER A 393 N VAL A 374 SHEET 4 AB1 4 ARG A 398 ALA A 403 -1 O LEU A 402 N ILE A 390 SHEET 1 AB2 5 ASN C 59 TYR C 60 0 SHEET 2 AB2 5 LEU C 45 ILE C 51 -1 N ARG C 50 O ASN C 59 SHEET 3 AB2 5 TRP C 33 GLN C 39 -1 N MET C 34 O ILE C 51 SHEET 4 AB2 5 ARG C 98 SER C 100 -1 O GLU C 99 N TRP C 33 SHEET 5 AB2 5 HIS C 116 PHE C 117 -1 O HIS C 116 N SER C 100 SHEET 1 AB3 2 THR E 91 TRP E 92 0 SHEET 2 AB3 2 VAL E 100 VAL E 101 -1 O VAL E 101 N THR E 91 SHEET 1 AB4 4 LEU G 4 SER G 7 0 SHEET 2 AB4 4 SER G 17 ALA G 24 -1 O ALA G 23 N LEU G 5 SHEET 3 AB4 4 THR G 78 ASN G 84 -1 O LEU G 81 N VAL G 20 SHEET 4 AB4 4 THR G 69 ASP G 73 -1 N ASP G 73 O THR G 78 SHEET 1 AB5 5 THR G 58 TYR G 60 0 SHEET 2 AB5 5 GLY G 44 ILE G 51 -1 N ALA G 50 O TYR G 59 SHEET 3 AB5 5 MET G 34 THR G 40 -1 N ARG G 38 O GLU G 46 SHEET 4 AB5 5 VAL G 93 PHE G 99 -1 O TYR G 95 N LEU G 37 SHEET 5 AB5 5 PHE G 108 TRP G 111 -1 O TYR G 110 N LYS G 98 SHEET 1 AB6 4 MET I 4 SER I 7 0 SHEET 2 AB6 4 SER I 22 SER I 25 -1 O ARG I 24 N THR I 5 SHEET 3 AB6 4 ASP I 75 ILE I 80 -1 O PHE I 76 N CYS I 23 SHEET 4 AB6 4 PHE I 67 SER I 72 -1 N SER I 68 O LYS I 79 SHEET 1 AB7 6 SER I 10 VAL I 13 0 SHEET 2 AB7 6 THR I 106 ILE I 110 1 O LYS I 107 N LEU I 11 SHEET 3 AB7 6 GLY I 89 GLN I 95 -1 N TYR I 91 O THR I 106 SHEET 4 AB7 6 LEU I 38 GLN I 43 -1 N ASP I 39 O MET I 94 SHEET 5 AB7 6 LEU I 51 TYR I 54 -1 O LEU I 52 N TRP I 40 SHEET 6 AB7 6 ASN I 58 ARG I 59 -1 O ASN I 58 N TYR I 54 SHEET 1 AB8 4 ILE B 31 PRO B 33 0 SHEET 2 AB8 4 ALA B 411 HIS B 421 -1 O THR B 420 N LYS B 32 SHEET 3 AB8 4 LYS B 424 ASN B 434 -1 O ILE B 430 N THR B 415 SHEET 4 AB8 4 PHE B 441 GLU B 449 -1 O PHE B 446 N HIS B 429 SHEET 1 AB9 2 SER B 48 LEU B 49 0 SHEET 2 AB9 2 LYS B 452 SER B 453 -1 O SER B 453 N SER B 48 SHEET 1 AC1 4 CYS B 73 ILE B 81 0 SHEET 2 AC1 4 TYR B 86 ILE B 93 -1 O ILE B 93 N CYS B 73 SHEET 3 AC1 4 SER B 103 VAL B 114 -1 O TYR B 104 N LEU B 92 SHEET 4 AC1 4 PRO B 120 ILE B 126 -1 O ASN B 123 N ILE B 111 SHEET 1 AC2 4 LYS B 137 LEU B 144 0 SHEET 2 AC2 4 ASP B 147 SER B 153 -1 O ASP B 147 N LEU B 144 SHEET 3 AC2 4 ILE B 171 VAL B 176 -1 O ASP B 174 N GLN B 150 SHEET 4 AC2 4 ARG B 186 PHE B 187 -1 O PHE B 187 N ILE B 171 SHEET 1 AC3 5 ILE B 192 SER B 193 0 SHEET 2 AC3 5 LYS B 276 TRP B 280 1 O VAL B 279 N SER B 193 SHEET 3 AC3 5 SER B 263 ASP B 268 -1 N ASP B 268 O LYS B 276 SHEET 4 AC3 5 LYS B 214 TYR B 220 -1 N GLY B 219 O SER B 263 SHEET 5 AC3 5 TYR B 202 PRO B 203 -1 N TYR B 202 O TYR B 220 SHEET 1 AC4 5 ILE B 192 SER B 193 0 SHEET 2 AC4 5 LYS B 276 TRP B 280 1 O VAL B 279 N SER B 193 SHEET 3 AC4 5 SER B 263 ASP B 268 -1 N ASP B 268 O LYS B 276 SHEET 4 AC4 5 LYS B 214 TYR B 220 -1 N GLY B 219 O SER B 263 SHEET 5 AC4 5 ILE B 209 TYR B 211 -1 N TYR B 211 O LYS B 214 SHEET 1 AC5 4 GLY B 293 LEU B 298 0 SHEET 2 AC5 4 LYS B 301 THR B 306 -1 O TYR B 303 N LEU B 296 SHEET 3 AC5 4 GLN B 316 ILE B 320 -1 O ILE B 320 N ILE B 302 SHEET 4 AC5 4 ILE B 330 THR B 333 -1 O LYS B 331 N ILE B 319 SHEET 1 AC6 4 ALA B 364 ASN B 368 0 SHEET 2 AC6 4 GLY B 371 LEU B 379 -1 O SER B 375 N TYR B 365 SHEET 3 AC6 4 PRO B 388 SER B 393 -1 O SER B 393 N VAL B 374 SHEET 4 AC6 4 ARG B 398 ALA B 403 -1 O LEU B 402 N ILE B 390 SHEET 1 AC7 3 MET D 34 GLN D 39 0 SHEET 2 AC7 3 LEU D 45 ILE D 51 -1 O SER D 49 N TRP D 36 SHEET 3 AC7 3 ASN D 59 TYR D 60 -1 O ASN D 59 N ARG D 50 SHEET 1 AC8 2 GLU D 99 ALA D 101 0 SHEET 2 AC8 2 TYR D 115 PHE D 117 -1 O HIS D 116 N SER D 100 SHEET 1 AC9 3 VAL F 34 ASP F 35 0 SHEET 2 AC9 3 ALA F 90 TRP F 92 -1 O ALA F 90 N ASP F 35 SHEET 3 AC9 3 VAL F 100 VAL F 101 -1 O VAL F 101 N THR F 91 SHEET 1 AD1 4 LEU H 4 SER H 7 0 SHEET 2 AD1 4 LEU H 18 ALA H 24 -1 O ALA H 23 N LEU H 5 SHEET 3 AD1 4 THR H 78 MET H 83 -1 O LEU H 81 N VAL H 20 SHEET 4 AD1 4 THR H 69 ASP H 73 -1 N ASP H 73 O THR H 78 SHEET 1 AD2 5 THR H 58 TYR H 60 0 SHEET 2 AD2 5 GLY H 44 ILE H 51 -1 N ALA H 50 O TYR H 59 SHEET 3 AD2 5 MET H 34 THR H 40 -1 N ARG H 38 O GLU H 46 SHEET 4 AD2 5 VAL H 93 PHE H 99 -1 O TYR H 95 N LEU H 37 SHEET 5 AD2 5 PHE H 108 TRP H 111 -1 O TYR H 110 N LYS H 98 SHEET 1 AD3 4 MET J 4 SER J 7 0 SHEET 2 AD3 4 SER J 22 SER J 25 -1 O ARG J 24 N THR J 5 SHEET 3 AD3 4 ASP J 75 ILE J 80 -1 O PHE J 76 N CYS J 23 SHEET 4 AD3 4 PHE J 67 SER J 72 -1 N SER J 68 O LYS J 79 SHEET 1 AD4 6 SER J 10 VAL J 13 0 SHEET 2 AD4 6 THR J 106 ILE J 110 1 O LYS J 107 N LEU J 11 SHEET 3 AD4 6 VAL J 90 GLN J 95 -1 N TYR J 91 O THR J 106 SHEET 4 AD4 6 LEU J 38 GLN J 43 -1 N ASP J 39 O MET J 94 SHEET 5 AD4 6 LEU J 51 TYR J 54 -1 O LEU J 52 N TRP J 40 SHEET 6 AD4 6 ASN J 58 ARG J 59 -1 O ASN J 58 N TYR J 54 SSBOND 1 CYS A 42 CYS A 454 1555 1555 2.02 SSBOND 2 CYS A 73 CYS A 97 1555 1555 2.03 SSBOND 3 CYS A 139 CYS A 152 1555 1555 2.03 SSBOND 4 CYS A 233 CYS A 246 1555 1555 2.03 SSBOND 5 CYS A 238 CYS A 352 1555 1555 2.05 SSBOND 6 CYS A 346 CYS A 356 1555 1555 2.04 SSBOND 7 CYS A 418 CYS A 427 1555 1555 2.03 SSBOND 8 CYS G 22 CYS G 96 1555 1555 2.03 SSBOND 9 CYS I 23 CYS I 93 1555 1555 2.03 SSBOND 10 CYS B 42 CYS B 454 1555 1555 2.02 SSBOND 11 CYS B 73 CYS B 97 1555 1555 2.04 SSBOND 12 CYS B 139 CYS B 152 1555 1555 2.03 SSBOND 13 CYS B 233 CYS B 246 1555 1555 2.03 SSBOND 14 CYS B 238 CYS B 352 1555 1555 2.04 SSBOND 15 CYS B 346 CYS B 356 1555 1555 2.03 SSBOND 16 CYS B 418 CYS B 427 1555 1555 2.03 SSBOND 17 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 18 CYS J 23 CYS J 93 1555 1555 2.03 CISPEP 1 THR A 52 PRO A 53 0 -6.10 CISPEP 2 ASP C 118 PRO C 119 0 -3.97 CISPEP 3 SER I 7 PRO I 8 0 -10.28 CISPEP 4 THR B 52 PRO B 53 0 -5.35 CISPEP 5 ASP D 118 PRO D 119 0 -1.89 CISPEP 6 SER J 7 PRO J 8 0 -10.06 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000