HEADER MEMBRANE PROTEIN 12-NOV-24 9EB9 TITLE HUMAN TRPML1 BOUND TO SYBODY94 COMPND MOL_ID: 1; COMPND 2 MOLECULE: SYBODY94; COMPND 3 CHAIN: E, F, G, H; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: MUCOLIPIN-1; COMPND 7 CHAIN: A, B, C, D; COMPND 8 SYNONYM: ML1,MG-2,MUCOLIPIDIN,TRANSIENT RECEPTOR POTENTIAL CHANNEL COMPND 9 MUCOLIPIN 1,TRPML1; COMPND 10 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 3 ORGANISM_TAXID: 32630; SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_COMMON: HUMAN; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 GENE: MCOLN1, ML4, MSTP080; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS TRPML1, SYBODY, ION CHANNEL, MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR R.P.PUMROY,S.P.SALPHATI,V.Y.MOISEENKOVA-BELL,S.NEWSTEAD REVDAT 1 21-JAN-26 9EB9 0 JRNL AUTH S.P.SALPHATI,R.P.PUMROY,C.R.CHRISTENSEN, JRNL AUTH 2 V.Y.MOISEENKOVA-BELL,S.NEWSTEAD JRNL TITL HUMAN TRPML1 BOUND TO SYBODY94 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 1 REMARK 1 REFERENCE 1 REMARK 1 AUTH D.LIEBSCHNER,P.V.AFONINE,M.L.BAKER,G.BUNKOCZI,V.B.CHEN, REMARK 1 AUTH 2 T.I.CROLL,B.HINTZE,L.W.HUNG,S.JAIN,A.J.MCCOY,N.W.MORIARTY, REMARK 1 AUTH 3 R.D.OEFFNER,B.K.POON,M.G.PRISANT,R.J.READ,J.S.RICHARDSON, REMARK 1 AUTH 4 D.C.RICHARDSON,M.D.SAMMITO,O.V.SOBOLEV,D.H.STOCKWELL, REMARK 1 AUTH 5 T.C.TERWILLIGER,A.G.URZHUMTSEV,L.L.VIDEAU,C.J.WILLIAMS, REMARK 1 AUTH 6 P.D.ADAMS REMARK 1 TITL MACROMOLECULAR STRUCTURE DETERMINATION USING X-RAYS, REMARK 1 TITL 2 NEUTRONS AND ELECTRONS: RECENT DEVELOPMENTS IN PHENIX REMARK 1 REF ACTA CRYSTALLOGR., SECT. D: V. 75 861 2019 REMARK 1 REF 2 BIOL. CRYSTALLOGR. REMARK 1 REFN ISSN 0907-4449 REMARK 1 PMID 31588918 REMARK 1 DOI 10.1107/S2059798319011471 REMARK 2 REMARK 2 RESOLUTION. 3.00 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.000 REMARK 3 NUMBER OF PARTICLES : 46205 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9EB9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 13-NOV-24. REMARK 100 THE DEPOSITION ID IS D_1000287626. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : COMPLEX OF THE TETRAMERIC REMARK 245 TRPML1 ION CHANNEL BOUND TO REMARK 245 FOUR COPIES OF SYBODY94 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4900.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: OCTAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, A, F, G, H, B, C, D, I, J, REMARK 350 AND CHAINS: K, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER E 118 REMARK 465 ALA E 119 REMARK 465 GLY E 120 REMARK 465 ARG E 121 REMARK 465 ALA E 122 REMARK 465 GLY E 123 REMARK 465 GLU E 124 REMARK 465 GLN E 125 REMARK 465 LYS E 126 REMARK 465 LEU E 127 REMARK 465 ILE E 128 REMARK 465 SER E 129 REMARK 465 GLU E 130 REMARK 465 GLU E 131 REMARK 465 ASP E 132 REMARK 465 LEU E 133 REMARK 465 ASN E 134 REMARK 465 SER E 135 REMARK 465 ALA E 136 REMARK 465 VAL E 137 REMARK 465 ASP E 138 REMARK 465 HIS E 139 REMARK 465 HIS E 140 REMARK 465 HIS E 141 REMARK 465 HIS E 142 REMARK 465 HIS E 143 REMARK 465 HIS E 144 REMARK 465 MET A 1 REMARK 465 THR A 2 REMARK 465 ALA A 3 REMARK 465 PRO A 4 REMARK 465 ALA A 5 REMARK 465 GLY A 6 REMARK 465 PRO A 7 REMARK 465 ARG A 8 REMARK 465 GLY A 9 REMARK 465 SER A 10 REMARK 465 GLU A 11 REMARK 465 THR A 12 REMARK 465 GLU A 13 REMARK 465 ARG A 14 REMARK 465 LEU A 15 REMARK 465 LEU A 16 REMARK 465 THR A 17 REMARK 465 PRO A 18 REMARK 465 ASN A 19 REMARK 465 PRO A 20 REMARK 465 GLY A 21 REMARK 465 TYR A 22 REMARK 465 GLY A 23 REMARK 465 THR A 24 REMARK 465 GLN A 25 REMARK 465 ALA A 26 REMARK 465 GLY A 27 REMARK 465 PRO A 28 REMARK 465 SER A 29 REMARK 465 PRO A 30 REMARK 465 ALA A 31 REMARK 465 PRO A 32 REMARK 465 PRO A 33 REMARK 465 THR A 34 REMARK 465 PRO A 35 REMARK 465 PRO A 36 REMARK 465 GLU A 37 REMARK 465 GLU A 38 REMARK 465 GLU A 39 REMARK 465 ASP A 40 REMARK 465 LEU A 41 REMARK 465 ARG A 42 REMARK 465 ARG A 43 REMARK 465 ARG A 44 REMARK 465 LEU A 45 REMARK 465 LYS A 46 REMARK 465 TYR A 47 REMARK 465 PHE A 48 REMARK 465 PHE A 49 REMARK 465 MET A 50 REMARK 465 SER A 51 REMARK 465 PRO A 52 REMARK 465 CYS A 53 REMARK 465 ASP A 54 REMARK 465 LYS A 55 REMARK 465 PHE A 56 REMARK 465 ARG A 57 REMARK 465 ALA A 58 REMARK 465 LYS A 59 REMARK 465 GLY A 60 REMARK 465 ARG A 61 REMARK 465 LYS A 62 REMARK 465 SER A 288 REMARK 465 VAL A 289 REMARK 465 PHE A 290 REMARK 465 GLN A 291 REMARK 465 HIS A 292 REMARK 465 GLY A 293 REMARK 465 ASP A 294 REMARK 465 ASN A 295 REMARK 465 SER A 296 REMARK 465 GLY A 323 REMARK 465 PHE A 324 REMARK 465 LEU A 325 REMARK 465 LEU A 326 REMARK 465 GLN A 327 REMARK 465 ASN A 328 REMARK 465 GLU A 329 REMARK 465 PHE A 330 REMARK 465 VAL A 331 REMARK 465 GLY A 332 REMARK 465 PHE A 333 REMARK 465 MET A 334 REMARK 465 TRP A 335 REMARK 465 ARG A 336 REMARK 465 GLN A 337 REMARK 465 ARG A 338 REMARK 465 GLY A 339 REMARK 465 ARG A 340 REMARK 465 VAL A 341 REMARK 465 ILE A 342 REMARK 465 SER A 343 REMARK 465 LEU A 344 REMARK 465 TRP A 345 REMARK 465 GLU A 346 REMARK 465 ARG A 347 REMARK 465 LEU A 348 REMARK 465 GLU A 349 REMARK 465 PHE A 350 REMARK 465 GLU A 376 REMARK 465 ALA A 377 REMARK 465 LYS A 378 REMARK 465 ASN A 379 REMARK 465 HIS A 526 REMARK 465 PRO A 527 REMARK 465 GLY A 528 REMARK 465 GLY A 529 REMARK 465 ALA A 530 REMARK 465 GLY A 531 REMARK 465 ALA A 532 REMARK 465 GLU A 533 REMARK 465 GLU A 534 REMARK 465 SER A 535 REMARK 465 GLU A 536 REMARK 465 LEU A 537 REMARK 465 GLN A 538 REMARK 465 ALA A 539 REMARK 465 TYR A 540 REMARK 465 ILE A 541 REMARK 465 ALA A 542 REMARK 465 GLN A 543 REMARK 465 CYS A 544 REMARK 465 GLN A 545 REMARK 465 ASP A 546 REMARK 465 SER A 547 REMARK 465 PRO A 548 REMARK 465 THR A 549 REMARK 465 SER A 550 REMARK 465 GLY A 551 REMARK 465 LYS A 552 REMARK 465 PHE A 553 REMARK 465 ARG A 554 REMARK 465 ARG A 555 REMARK 465 GLY A 556 REMARK 465 SER A 557 REMARK 465 GLY A 558 REMARK 465 SER A 559 REMARK 465 ALA A 560 REMARK 465 CYS A 561 REMARK 465 SER A 562 REMARK 465 LEU A 563 REMARK 465 LEU A 564 REMARK 465 CYS A 565 REMARK 465 CYS A 566 REMARK 465 CYS A 567 REMARK 465 GLY A 568 REMARK 465 ARG A 569 REMARK 465 ASP A 570 REMARK 465 PRO A 571 REMARK 465 SER A 572 REMARK 465 GLU A 573 REMARK 465 GLU A 574 REMARK 465 HIS A 575 REMARK 465 SER A 576 REMARK 465 LEU A 577 REMARK 465 LEU A 578 REMARK 465 VAL A 579 REMARK 465 ASN A 580 REMARK 465 SER F 118 REMARK 465 ALA F 119 REMARK 465 GLY F 120 REMARK 465 ARG F 121 REMARK 465 ALA F 122 REMARK 465 GLY F 123 REMARK 465 GLU F 124 REMARK 465 GLN F 125 REMARK 465 LYS F 126 REMARK 465 LEU F 127 REMARK 465 ILE F 128 REMARK 465 SER F 129 REMARK 465 GLU F 130 REMARK 465 GLU F 131 REMARK 465 ASP F 132 REMARK 465 LEU F 133 REMARK 465 ASN F 134 REMARK 465 SER F 135 REMARK 465 ALA F 136 REMARK 465 VAL F 137 REMARK 465 ASP F 138 REMARK 465 HIS F 139 REMARK 465 HIS F 140 REMARK 465 HIS F 141 REMARK 465 HIS F 142 REMARK 465 HIS F 143 REMARK 465 HIS F 144 REMARK 465 SER G 118 REMARK 465 ALA G 119 REMARK 465 GLY G 120 REMARK 465 ARG G 121 REMARK 465 ALA G 122 REMARK 465 GLY G 123 REMARK 465 GLU G 124 REMARK 465 GLN G 125 REMARK 465 LYS G 126 REMARK 465 LEU G 127 REMARK 465 ILE G 128 REMARK 465 SER G 129 REMARK 465 GLU G 130 REMARK 465 GLU G 131 REMARK 465 ASP G 132 REMARK 465 LEU G 133 REMARK 465 ASN G 134 REMARK 465 SER G 135 REMARK 465 ALA G 136 REMARK 465 VAL G 137 REMARK 465 ASP G 138 REMARK 465 HIS G 139 REMARK 465 HIS G 140 REMARK 465 HIS G 141 REMARK 465 HIS G 142 REMARK 465 HIS G 143 REMARK 465 HIS G 144 REMARK 465 SER H 118 REMARK 465 ALA H 119 REMARK 465 GLY H 120 REMARK 465 ARG H 121 REMARK 465 ALA H 122 REMARK 465 GLY H 123 REMARK 465 GLU H 124 REMARK 465 GLN H 125 REMARK 465 LYS H 126 REMARK 465 LEU H 127 REMARK 465 ILE H 128 REMARK 465 SER H 129 REMARK 465 GLU H 130 REMARK 465 GLU H 131 REMARK 465 ASP H 132 REMARK 465 LEU H 133 REMARK 465 ASN H 134 REMARK 465 SER H 135 REMARK 465 ALA H 136 REMARK 465 VAL H 137 REMARK 465 ASP H 138 REMARK 465 HIS H 139 REMARK 465 HIS H 140 REMARK 465 HIS H 141 REMARK 465 HIS H 142 REMARK 465 HIS H 143 REMARK 465 HIS H 144 REMARK 465 MET B 1 REMARK 465 THR B 2 REMARK 465 ALA B 3 REMARK 465 PRO B 4 REMARK 465 ALA B 5 REMARK 465 GLY B 6 REMARK 465 PRO B 7 REMARK 465 ARG B 8 REMARK 465 GLY B 9 REMARK 465 SER B 10 REMARK 465 GLU B 11 REMARK 465 THR B 12 REMARK 465 GLU B 13 REMARK 465 ARG B 14 REMARK 465 LEU B 15 REMARK 465 LEU B 16 REMARK 465 THR B 17 REMARK 465 PRO B 18 REMARK 465 ASN B 19 REMARK 465 PRO B 20 REMARK 465 GLY B 21 REMARK 465 TYR B 22 REMARK 465 GLY B 23 REMARK 465 THR B 24 REMARK 465 GLN B 25 REMARK 465 ALA B 26 REMARK 465 GLY B 27 REMARK 465 PRO B 28 REMARK 465 SER B 29 REMARK 465 PRO B 30 REMARK 465 ALA B 31 REMARK 465 PRO B 32 REMARK 465 PRO B 33 REMARK 465 THR B 34 REMARK 465 PRO B 35 REMARK 465 PRO B 36 REMARK 465 GLU B 37 REMARK 465 GLU B 38 REMARK 465 GLU B 39 REMARK 465 ASP B 40 REMARK 465 LEU B 41 REMARK 465 ARG B 42 REMARK 465 ARG B 43 REMARK 465 ARG B 44 REMARK 465 LEU B 45 REMARK 465 LYS B 46 REMARK 465 TYR B 47 REMARK 465 PHE B 48 REMARK 465 PHE B 49 REMARK 465 MET B 50 REMARK 465 SER B 51 REMARK 465 PRO B 52 REMARK 465 CYS B 53 REMARK 465 ASP B 54 REMARK 465 LYS B 55 REMARK 465 PHE B 56 REMARK 465 ARG B 57 REMARK 465 ALA B 58 REMARK 465 LYS B 59 REMARK 465 GLY B 60 REMARK 465 ARG B 61 REMARK 465 LYS B 62 REMARK 465 SER B 288 REMARK 465 VAL B 289 REMARK 465 PHE B 290 REMARK 465 GLN B 291 REMARK 465 HIS B 292 REMARK 465 GLY B 293 REMARK 465 ASP B 294 REMARK 465 ASN B 295 REMARK 465 SER B 296 REMARK 465 GLY B 323 REMARK 465 PHE B 324 REMARK 465 LEU B 325 REMARK 465 LEU B 326 REMARK 465 GLN B 327 REMARK 465 ASN B 328 REMARK 465 GLU B 329 REMARK 465 PHE B 330 REMARK 465 VAL B 331 REMARK 465 GLY B 332 REMARK 465 PHE B 333 REMARK 465 MET B 334 REMARK 465 TRP B 335 REMARK 465 ARG B 336 REMARK 465 GLN B 337 REMARK 465 ARG B 338 REMARK 465 GLY B 339 REMARK 465 ARG B 340 REMARK 465 VAL B 341 REMARK 465 ILE B 342 REMARK 465 SER B 343 REMARK 465 LEU B 344 REMARK 465 TRP B 345 REMARK 465 GLU B 346 REMARK 465 ARG B 347 REMARK 465 LEU B 348 REMARK 465 GLU B 349 REMARK 465 PHE B 350 REMARK 465 GLU B 376 REMARK 465 ALA B 377 REMARK 465 LYS B 378 REMARK 465 ASN B 379 REMARK 465 HIS B 526 REMARK 465 PRO B 527 REMARK 465 GLY B 528 REMARK 465 GLY B 529 REMARK 465 ALA B 530 REMARK 465 GLY B 531 REMARK 465 ALA B 532 REMARK 465 GLU B 533 REMARK 465 GLU B 534 REMARK 465 SER B 535 REMARK 465 GLU B 536 REMARK 465 LEU B 537 REMARK 465 GLN B 538 REMARK 465 ALA B 539 REMARK 465 TYR B 540 REMARK 465 ILE B 541 REMARK 465 ALA B 542 REMARK 465 GLN B 543 REMARK 465 CYS B 544 REMARK 465 GLN B 545 REMARK 465 ASP B 546 REMARK 465 SER B 547 REMARK 465 PRO B 548 REMARK 465 THR B 549 REMARK 465 SER B 550 REMARK 465 GLY B 551 REMARK 465 LYS B 552 REMARK 465 PHE B 553 REMARK 465 ARG B 554 REMARK 465 ARG B 555 REMARK 465 GLY B 556 REMARK 465 SER B 557 REMARK 465 GLY B 558 REMARK 465 SER B 559 REMARK 465 ALA B 560 REMARK 465 CYS B 561 REMARK 465 SER B 562 REMARK 465 LEU B 563 REMARK 465 LEU B 564 REMARK 465 CYS B 565 REMARK 465 CYS B 566 REMARK 465 CYS B 567 REMARK 465 GLY B 568 REMARK 465 ARG B 569 REMARK 465 ASP B 570 REMARK 465 PRO B 571 REMARK 465 SER B 572 REMARK 465 GLU B 573 REMARK 465 GLU B 574 REMARK 465 HIS B 575 REMARK 465 SER B 576 REMARK 465 LEU B 577 REMARK 465 LEU B 578 REMARK 465 VAL B 579 REMARK 465 ASN B 580 REMARK 465 MET C 1 REMARK 465 THR C 2 REMARK 465 ALA C 3 REMARK 465 PRO C 4 REMARK 465 ALA C 5 REMARK 465 GLY C 6 REMARK 465 PRO C 7 REMARK 465 ARG C 8 REMARK 465 GLY C 9 REMARK 465 SER C 10 REMARK 465 GLU C 11 REMARK 465 THR C 12 REMARK 465 GLU C 13 REMARK 465 ARG C 14 REMARK 465 LEU C 15 REMARK 465 LEU C 16 REMARK 465 THR C 17 REMARK 465 PRO C 18 REMARK 465 ASN C 19 REMARK 465 PRO C 20 REMARK 465 GLY C 21 REMARK 465 TYR C 22 REMARK 465 GLY C 23 REMARK 465 THR C 24 REMARK 465 GLN C 25 REMARK 465 ALA C 26 REMARK 465 GLY C 27 REMARK 465 PRO C 28 REMARK 465 SER C 29 REMARK 465 PRO C 30 REMARK 465 ALA C 31 REMARK 465 PRO C 32 REMARK 465 PRO C 33 REMARK 465 THR C 34 REMARK 465 PRO C 35 REMARK 465 PRO C 36 REMARK 465 GLU C 37 REMARK 465 GLU C 38 REMARK 465 GLU C 39 REMARK 465 ASP C 40 REMARK 465 LEU C 41 REMARK 465 ARG C 42 REMARK 465 ARG C 43 REMARK 465 ARG C 44 REMARK 465 LEU C 45 REMARK 465 LYS C 46 REMARK 465 TYR C 47 REMARK 465 PHE C 48 REMARK 465 PHE C 49 REMARK 465 MET C 50 REMARK 465 SER C 51 REMARK 465 PRO C 52 REMARK 465 CYS C 53 REMARK 465 ASP C 54 REMARK 465 LYS C 55 REMARK 465 PHE C 56 REMARK 465 ARG C 57 REMARK 465 ALA C 58 REMARK 465 LYS C 59 REMARK 465 GLY C 60 REMARK 465 ARG C 61 REMARK 465 LYS C 62 REMARK 465 SER C 288 REMARK 465 VAL C 289 REMARK 465 PHE C 290 REMARK 465 GLN C 291 REMARK 465 HIS C 292 REMARK 465 GLY C 293 REMARK 465 ASP C 294 REMARK 465 ASN C 295 REMARK 465 SER C 296 REMARK 465 GLY C 323 REMARK 465 PHE C 324 REMARK 465 LEU C 325 REMARK 465 LEU C 326 REMARK 465 GLN C 327 REMARK 465 ASN C 328 REMARK 465 GLU C 329 REMARK 465 PHE C 330 REMARK 465 VAL C 331 REMARK 465 GLY C 332 REMARK 465 PHE C 333 REMARK 465 MET C 334 REMARK 465 TRP C 335 REMARK 465 ARG C 336 REMARK 465 GLN C 337 REMARK 465 ARG C 338 REMARK 465 GLY C 339 REMARK 465 ARG C 340 REMARK 465 VAL C 341 REMARK 465 ILE C 342 REMARK 465 SER C 343 REMARK 465 LEU C 344 REMARK 465 TRP C 345 REMARK 465 GLU C 346 REMARK 465 ARG C 347 REMARK 465 LEU C 348 REMARK 465 GLU C 349 REMARK 465 PHE C 350 REMARK 465 GLU C 376 REMARK 465 ALA C 377 REMARK 465 LYS C 378 REMARK 465 ASN C 379 REMARK 465 HIS C 526 REMARK 465 PRO C 527 REMARK 465 GLY C 528 REMARK 465 GLY C 529 REMARK 465 ALA C 530 REMARK 465 GLY C 531 REMARK 465 ALA C 532 REMARK 465 GLU C 533 REMARK 465 GLU C 534 REMARK 465 SER C 535 REMARK 465 GLU C 536 REMARK 465 LEU C 537 REMARK 465 GLN C 538 REMARK 465 ALA C 539 REMARK 465 TYR C 540 REMARK 465 ILE C 541 REMARK 465 ALA C 542 REMARK 465 GLN C 543 REMARK 465 CYS C 544 REMARK 465 GLN C 545 REMARK 465 ASP C 546 REMARK 465 SER C 547 REMARK 465 PRO C 548 REMARK 465 THR C 549 REMARK 465 SER C 550 REMARK 465 GLY C 551 REMARK 465 LYS C 552 REMARK 465 PHE C 553 REMARK 465 ARG C 554 REMARK 465 ARG C 555 REMARK 465 GLY C 556 REMARK 465 SER C 557 REMARK 465 GLY C 558 REMARK 465 SER C 559 REMARK 465 ALA C 560 REMARK 465 CYS C 561 REMARK 465 SER C 562 REMARK 465 LEU C 563 REMARK 465 LEU C 564 REMARK 465 CYS C 565 REMARK 465 CYS C 566 REMARK 465 CYS C 567 REMARK 465 GLY C 568 REMARK 465 ARG C 569 REMARK 465 ASP C 570 REMARK 465 PRO C 571 REMARK 465 SER C 572 REMARK 465 GLU C 573 REMARK 465 GLU C 574 REMARK 465 HIS C 575 REMARK 465 SER C 576 REMARK 465 LEU C 577 REMARK 465 LEU C 578 REMARK 465 VAL C 579 REMARK 465 ASN C 580 REMARK 465 MET D 1 REMARK 465 THR D 2 REMARK 465 ALA D 3 REMARK 465 PRO D 4 REMARK 465 ALA D 5 REMARK 465 GLY D 6 REMARK 465 PRO D 7 REMARK 465 ARG D 8 REMARK 465 GLY D 9 REMARK 465 SER D 10 REMARK 465 GLU D 11 REMARK 465 THR D 12 REMARK 465 GLU D 13 REMARK 465 ARG D 14 REMARK 465 LEU D 15 REMARK 465 LEU D 16 REMARK 465 THR D 17 REMARK 465 PRO D 18 REMARK 465 ASN D 19 REMARK 465 PRO D 20 REMARK 465 GLY D 21 REMARK 465 TYR D 22 REMARK 465 GLY D 23 REMARK 465 THR D 24 REMARK 465 GLN D 25 REMARK 465 ALA D 26 REMARK 465 GLY D 27 REMARK 465 PRO D 28 REMARK 465 SER D 29 REMARK 465 PRO D 30 REMARK 465 ALA D 31 REMARK 465 PRO D 32 REMARK 465 PRO D 33 REMARK 465 THR D 34 REMARK 465 PRO D 35 REMARK 465 PRO D 36 REMARK 465 GLU D 37 REMARK 465 GLU D 38 REMARK 465 GLU D 39 REMARK 465 ASP D 40 REMARK 465 LEU D 41 REMARK 465 ARG D 42 REMARK 465 ARG D 43 REMARK 465 ARG D 44 REMARK 465 LEU D 45 REMARK 465 LYS D 46 REMARK 465 TYR D 47 REMARK 465 PHE D 48 REMARK 465 PHE D 49 REMARK 465 MET D 50 REMARK 465 SER D 51 REMARK 465 PRO D 52 REMARK 465 CYS D 53 REMARK 465 ASP D 54 REMARK 465 LYS D 55 REMARK 465 PHE D 56 REMARK 465 ARG D 57 REMARK 465 ALA D 58 REMARK 465 LYS D 59 REMARK 465 GLY D 60 REMARK 465 ARG D 61 REMARK 465 LYS D 62 REMARK 465 SER D 288 REMARK 465 VAL D 289 REMARK 465 PHE D 290 REMARK 465 GLN D 291 REMARK 465 HIS D 292 REMARK 465 GLY D 293 REMARK 465 ASP D 294 REMARK 465 ASN D 295 REMARK 465 SER D 296 REMARK 465 GLY D 323 REMARK 465 PHE D 324 REMARK 465 LEU D 325 REMARK 465 LEU D 326 REMARK 465 GLN D 327 REMARK 465 ASN D 328 REMARK 465 GLU D 329 REMARK 465 PHE D 330 REMARK 465 VAL D 331 REMARK 465 GLY D 332 REMARK 465 PHE D 333 REMARK 465 MET D 334 REMARK 465 TRP D 335 REMARK 465 ARG D 336 REMARK 465 GLN D 337 REMARK 465 ARG D 338 REMARK 465 GLY D 339 REMARK 465 ARG D 340 REMARK 465 VAL D 341 REMARK 465 ILE D 342 REMARK 465 SER D 343 REMARK 465 LEU D 344 REMARK 465 TRP D 345 REMARK 465 GLU D 346 REMARK 465 ARG D 347 REMARK 465 LEU D 348 REMARK 465 GLU D 349 REMARK 465 PHE D 350 REMARK 465 GLU D 376 REMARK 465 ALA D 377 REMARK 465 LYS D 378 REMARK 465 ASN D 379 REMARK 465 HIS D 526 REMARK 465 PRO D 527 REMARK 465 GLY D 528 REMARK 465 GLY D 529 REMARK 465 ALA D 530 REMARK 465 GLY D 531 REMARK 465 ALA D 532 REMARK 465 GLU D 533 REMARK 465 GLU D 534 REMARK 465 SER D 535 REMARK 465 GLU D 536 REMARK 465 LEU D 537 REMARK 465 GLN D 538 REMARK 465 ALA D 539 REMARK 465 TYR D 540 REMARK 465 ILE D 541 REMARK 465 ALA D 542 REMARK 465 GLN D 543 REMARK 465 CYS D 544 REMARK 465 GLN D 545 REMARK 465 ASP D 546 REMARK 465 SER D 547 REMARK 465 PRO D 548 REMARK 465 THR D 549 REMARK 465 SER D 550 REMARK 465 GLY D 551 REMARK 465 LYS D 552 REMARK 465 PHE D 553 REMARK 465 ARG D 554 REMARK 465 ARG D 555 REMARK 465 GLY D 556 REMARK 465 SER D 557 REMARK 465 GLY D 558 REMARK 465 SER D 559 REMARK 465 ALA D 560 REMARK 465 CYS D 561 REMARK 465 SER D 562 REMARK 465 LEU D 563 REMARK 465 LEU D 564 REMARK 465 CYS D 565 REMARK 465 CYS D 566 REMARK 465 CYS D 567 REMARK 465 GLY D 568 REMARK 465 ARG D 569 REMARK 465 ASP D 570 REMARK 465 PRO D 571 REMARK 465 SER D 572 REMARK 465 GLU D 573 REMARK 465 GLU D 574 REMARK 465 HIS D 575 REMARK 465 SER D 576 REMARK 465 LEU D 577 REMARK 465 LEU D 578 REMARK 465 VAL D 579 REMARK 465 ASN D 580 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LEU A 245 CG CD1 CD2 REMARK 470 ASN A 248 CG OD1 ND2 REMARK 470 LEU A 314 CG CD1 CD2 REMARK 470 ARG A 318 CG CD NE CZ NH1 NH2 REMARK 470 LEU A 320 CG CD1 CD2 REMARK 470 LEU A 321 CG CD1 CD2 REMARK 470 LEU B 245 CG CD1 CD2 REMARK 470 ASN B 248 CG OD1 ND2 REMARK 470 LEU B 314 CG CD1 CD2 REMARK 470 ARG B 318 CG CD NE CZ NH1 NH2 REMARK 470 LEU B 320 CG CD1 CD2 REMARK 470 LEU B 321 CG CD1 CD2 REMARK 470 LEU C 245 CG CD1 CD2 REMARK 470 ASN C 248 CG OD1 ND2 REMARK 470 LEU C 314 CG CD1 CD2 REMARK 470 ARG C 318 CG CD NE CZ NH1 NH2 REMARK 470 LEU C 320 CG CD1 CD2 REMARK 470 LEU C 321 CG CD1 CD2 REMARK 470 LEU D 245 CG CD1 CD2 REMARK 470 ASN D 248 CG OD1 ND2 REMARK 470 LEU D 314 CG CD1 CD2 REMARK 470 ARG D 318 CG CD NE CZ NH1 NH2 REMARK 470 LEU D 320 CG CD1 CD2 REMARK 470 LEU D 321 CG CD1 CD2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 HIS A 286 72.44 53.67 REMARK 500 HIS B 286 72.44 53.67 REMARK 500 HIS C 286 72.50 53.65 REMARK 500 HIS D 286 72.47 53.60 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-47874 RELATED DB: EMDB REMARK 900 HUMAN TRPML1 BOUND TO SYBODY94 DBREF 9EB9 E 1 144 PDB 9EB9 9EB9 1 144 DBREF 9EB9 A 1 580 UNP Q9GZU1 MCLN1_HUMAN 1 580 DBREF 9EB9 F 1 144 PDB 9EB9 9EB9 1 144 DBREF 9EB9 G 1 144 PDB 9EB9 9EB9 1 144 DBREF 9EB9 H 1 144 PDB 9EB9 9EB9 1 144 DBREF 9EB9 B 1 580 UNP Q9GZU1 MCLN1_HUMAN 1 580 DBREF 9EB9 C 1 580 UNP Q9GZU1 MCLN1_HUMAN 1 580 DBREF 9EB9 D 1 580 UNP Q9GZU1 MCLN1_HUMAN 1 580 SEQRES 1 E 144 GLY SER SER SER GLN VAL GLN LEU VAL GLU SER GLY GLY SEQRES 2 E 144 GLY LEU VAL GLN ALA GLY GLY SER LEU ARG LEU SER CYS SEQRES 3 E 144 ALA ALA SER GLY PHE PRO VAL TYR HIS HIS PHE MET ARG SEQRES 4 E 144 TRP TYR ARG GLN ALA PRO GLY LYS GLU ARG GLU TRP VAL SEQRES 5 E 144 ALA ALA ILE HIS SER GLU GLY GLN THR THR GLU TYR ALA SEQRES 6 E 144 ASP SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SEQRES 7 E 144 ALA LYS ASN THR VAL TYR LEU GLN MET ASN SER LEU LYS SEQRES 8 E 144 PRO GLU ASP THR ALA VAL TYR TYR CYS TYR VAL MET VAL SEQRES 9 E 144 GLY GLN TRP TYR HIS GLY GLN GLY THR GLN VAL THR VAL SEQRES 10 E 144 SER ALA GLY ARG ALA GLY GLU GLN LYS LEU ILE SER GLU SEQRES 11 E 144 GLU ASP LEU ASN SER ALA VAL ASP HIS HIS HIS HIS HIS SEQRES 12 E 144 HIS SEQRES 1 A 580 MET THR ALA PRO ALA GLY PRO ARG GLY SER GLU THR GLU SEQRES 2 A 580 ARG LEU LEU THR PRO ASN PRO GLY TYR GLY THR GLN ALA SEQRES 3 A 580 GLY PRO SER PRO ALA PRO PRO THR PRO PRO GLU GLU GLU SEQRES 4 A 580 ASP LEU ARG ARG ARG LEU LYS TYR PHE PHE MET SER PRO SEQRES 5 A 580 CYS ASP LYS PHE ARG ALA LYS GLY ARG LYS PRO CYS LYS SEQRES 6 A 580 LEU MET LEU GLN VAL VAL LYS ILE LEU VAL VAL THR VAL SEQRES 7 A 580 GLN LEU ILE LEU PHE GLY LEU SER ASN GLN LEU ALA VAL SEQRES 8 A 580 THR PHE ARG GLU GLU ASN THR ILE ALA PHE ARG HIS LEU SEQRES 9 A 580 PHE LEU LEU GLY TYR SER ASP GLY ALA ASP ASP THR PHE SEQRES 10 A 580 ALA ALA TYR THR ARG GLU GLN LEU TYR GLN ALA ILE PHE SEQRES 11 A 580 HIS ALA VAL ASP GLN TYR LEU ALA LEU PRO ASP VAL SER SEQRES 12 A 580 LEU GLY ARG TYR ALA TYR VAL ARG GLY GLY GLY ASP PRO SEQRES 13 A 580 TRP THR ASN GLY SER GLY LEU ALA LEU CYS GLN ARG TYR SEQRES 14 A 580 TYR HIS ARG GLY HIS VAL ASP PRO ALA ASN ASP THR PHE SEQRES 15 A 580 ASP ILE ASP PRO MET VAL VAL THR ASP CYS ILE GLN VAL SEQRES 16 A 580 ASP PRO PRO GLU ARG PRO PRO PRO PRO PRO SER ASP ASP SEQRES 17 A 580 LEU THR LEU LEU GLU SER SER SER SER TYR LYS ASN LEU SEQRES 18 A 580 THR LEU LYS PHE HIS LYS LEU VAL ASN VAL THR ILE HIS SEQRES 19 A 580 PHE ARG LEU LYS THR ILE ASN LEU GLN SER LEU ILE ASN SEQRES 20 A 580 ASN GLU ILE PRO ASP CYS TYR THR PHE SER VAL LEU ILE SEQRES 21 A 580 THR PHE ASP ASN LYS ALA HIS SER GLY ARG ILE PRO ILE SEQRES 22 A 580 SER LEU GLU THR GLN ALA HIS ILE GLN GLU CYS LYS HIS SEQRES 23 A 580 PRO SER VAL PHE GLN HIS GLY ASP ASN SER PHE ARG LEU SEQRES 24 A 580 LEU PHE ASP VAL VAL VAL ILE LEU THR CYS SER LEU SER SEQRES 25 A 580 PHE LEU LEU CYS ALA ARG SER LEU LEU ARG GLY PHE LEU SEQRES 26 A 580 LEU GLN ASN GLU PHE VAL GLY PHE MET TRP ARG GLN ARG SEQRES 27 A 580 GLY ARG VAL ILE SER LEU TRP GLU ARG LEU GLU PHE VAL SEQRES 28 A 580 ASN GLY TRP TYR ILE LEU LEU VAL THR SER ASP VAL LEU SEQRES 29 A 580 THR ILE SER GLY THR ILE MET LYS ILE GLY ILE GLU ALA SEQRES 30 A 580 LYS ASN LEU ALA SER TYR ASP VAL CYS SER ILE LEU LEU SEQRES 31 A 580 GLY THR SER THR LEU LEU VAL TRP VAL GLY VAL ILE ARG SEQRES 32 A 580 TYR LEU THR PHE PHE HIS ASN TYR ASN ILE LEU ILE ALA SEQRES 33 A 580 THR LEU ARG VAL ALA LEU PRO SER VAL MET ARG PHE CYS SEQRES 34 A 580 CYS CYS VAL ALA VAL ILE TYR LEU GLY TYR CYS PHE CYS SEQRES 35 A 580 GLY TRP ILE VAL LEU GLY PRO TYR HIS VAL LYS PHE ARG SEQRES 36 A 580 SER LEU SER MET VAL SER GLU CYS LEU PHE SER LEU ILE SEQRES 37 A 580 ASN GLY ASP ASP MET PHE VAL THR PHE ALA ALA MET GLN SEQRES 38 A 580 ALA GLN GLN GLY ARG SER SER LEU VAL TRP LEU PHE SER SEQRES 39 A 580 GLN LEU TYR LEU TYR SER PHE ILE SER LEU PHE ILE TYR SEQRES 40 A 580 MET VAL LEU SER LEU PHE ILE ALA LEU ILE THR GLY ALA SEQRES 41 A 580 TYR ASP THR ILE LYS HIS PRO GLY GLY ALA GLY ALA GLU SEQRES 42 A 580 GLU SER GLU LEU GLN ALA TYR ILE ALA GLN CYS GLN ASP SEQRES 43 A 580 SER PRO THR SER GLY LYS PHE ARG ARG GLY SER GLY SER SEQRES 44 A 580 ALA CYS SER LEU LEU CYS CYS CYS GLY ARG ASP PRO SER SEQRES 45 A 580 GLU GLU HIS SER LEU LEU VAL ASN SEQRES 1 F 144 GLY SER SER SER GLN VAL GLN LEU VAL GLU SER GLY GLY SEQRES 2 F 144 GLY LEU VAL GLN ALA GLY GLY SER LEU ARG LEU SER CYS SEQRES 3 F 144 ALA ALA SER GLY PHE PRO VAL TYR HIS HIS PHE MET ARG SEQRES 4 F 144 TRP TYR ARG GLN ALA PRO GLY LYS GLU ARG GLU TRP VAL SEQRES 5 F 144 ALA ALA ILE HIS SER GLU GLY GLN THR THR GLU TYR ALA SEQRES 6 F 144 ASP SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SEQRES 7 F 144 ALA LYS ASN THR VAL TYR LEU GLN MET ASN SER LEU LYS SEQRES 8 F 144 PRO GLU ASP THR ALA VAL TYR TYR CYS TYR VAL MET VAL SEQRES 9 F 144 GLY GLN TRP TYR HIS GLY GLN GLY THR GLN VAL THR VAL SEQRES 10 F 144 SER ALA GLY ARG ALA GLY GLU GLN LYS LEU ILE SER GLU SEQRES 11 F 144 GLU ASP LEU ASN SER ALA VAL ASP HIS HIS HIS HIS HIS SEQRES 12 F 144 HIS SEQRES 1 G 144 GLY SER SER SER GLN VAL GLN LEU VAL GLU SER GLY GLY SEQRES 2 G 144 GLY LEU VAL GLN ALA GLY GLY SER LEU ARG LEU SER CYS SEQRES 3 G 144 ALA ALA SER GLY PHE PRO VAL TYR HIS HIS PHE MET ARG SEQRES 4 G 144 TRP TYR ARG GLN ALA PRO GLY LYS GLU ARG GLU TRP VAL SEQRES 5 G 144 ALA ALA ILE HIS SER GLU GLY GLN THR THR GLU TYR ALA SEQRES 6 G 144 ASP SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SEQRES 7 G 144 ALA LYS ASN THR VAL TYR LEU GLN MET ASN SER LEU LYS SEQRES 8 G 144 PRO GLU ASP THR ALA VAL TYR TYR CYS TYR VAL MET VAL SEQRES 9 G 144 GLY GLN TRP TYR HIS GLY GLN GLY THR GLN VAL THR VAL SEQRES 10 G 144 SER ALA GLY ARG ALA GLY GLU GLN LYS LEU ILE SER GLU SEQRES 11 G 144 GLU ASP LEU ASN SER ALA VAL ASP HIS HIS HIS HIS HIS SEQRES 12 G 144 HIS SEQRES 1 H 144 GLY SER SER SER GLN VAL GLN LEU VAL GLU SER GLY GLY SEQRES 2 H 144 GLY LEU VAL GLN ALA GLY GLY SER LEU ARG LEU SER CYS SEQRES 3 H 144 ALA ALA SER GLY PHE PRO VAL TYR HIS HIS PHE MET ARG SEQRES 4 H 144 TRP TYR ARG GLN ALA PRO GLY LYS GLU ARG GLU TRP VAL SEQRES 5 H 144 ALA ALA ILE HIS SER GLU GLY GLN THR THR GLU TYR ALA SEQRES 6 H 144 ASP SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SEQRES 7 H 144 ALA LYS ASN THR VAL TYR LEU GLN MET ASN SER LEU LYS SEQRES 8 H 144 PRO GLU ASP THR ALA VAL TYR TYR CYS TYR VAL MET VAL SEQRES 9 H 144 GLY GLN TRP TYR HIS GLY GLN GLY THR GLN VAL THR VAL SEQRES 10 H 144 SER ALA GLY ARG ALA GLY GLU GLN LYS LEU ILE SER GLU SEQRES 11 H 144 GLU ASP LEU ASN SER ALA VAL ASP HIS HIS HIS HIS HIS SEQRES 12 H 144 HIS SEQRES 1 B 580 MET THR ALA PRO ALA GLY PRO ARG GLY SER GLU THR GLU SEQRES 2 B 580 ARG LEU LEU THR PRO ASN PRO GLY TYR GLY THR GLN ALA SEQRES 3 B 580 GLY PRO SER PRO ALA PRO PRO THR PRO PRO GLU GLU GLU SEQRES 4 B 580 ASP LEU ARG ARG ARG LEU LYS TYR PHE PHE MET SER PRO SEQRES 5 B 580 CYS ASP LYS PHE ARG ALA LYS GLY ARG LYS PRO CYS LYS SEQRES 6 B 580 LEU MET LEU GLN VAL VAL LYS ILE LEU VAL VAL THR VAL SEQRES 7 B 580 GLN LEU ILE LEU PHE GLY LEU SER ASN GLN LEU ALA VAL SEQRES 8 B 580 THR PHE ARG GLU GLU ASN THR ILE ALA PHE ARG HIS LEU SEQRES 9 B 580 PHE LEU LEU GLY TYR SER ASP GLY ALA ASP ASP THR PHE SEQRES 10 B 580 ALA ALA TYR THR ARG GLU GLN LEU TYR GLN ALA ILE PHE SEQRES 11 B 580 HIS ALA VAL ASP GLN TYR LEU ALA LEU PRO ASP VAL SER SEQRES 12 B 580 LEU GLY ARG TYR ALA TYR VAL ARG GLY GLY GLY ASP PRO SEQRES 13 B 580 TRP THR ASN GLY SER GLY LEU ALA LEU CYS GLN ARG TYR SEQRES 14 B 580 TYR HIS ARG GLY HIS VAL ASP PRO ALA ASN ASP THR PHE SEQRES 15 B 580 ASP ILE ASP PRO MET VAL VAL THR ASP CYS ILE GLN VAL SEQRES 16 B 580 ASP PRO PRO GLU ARG PRO PRO PRO PRO PRO SER ASP ASP SEQRES 17 B 580 LEU THR LEU LEU GLU SER SER SER SER TYR LYS ASN LEU SEQRES 18 B 580 THR LEU LYS PHE HIS LYS LEU VAL ASN VAL THR ILE HIS SEQRES 19 B 580 PHE ARG LEU LYS THR ILE ASN LEU GLN SER LEU ILE ASN SEQRES 20 B 580 ASN GLU ILE PRO ASP CYS TYR THR PHE SER VAL LEU ILE SEQRES 21 B 580 THR PHE ASP ASN LYS ALA HIS SER GLY ARG ILE PRO ILE SEQRES 22 B 580 SER LEU GLU THR GLN ALA HIS ILE GLN GLU CYS LYS HIS SEQRES 23 B 580 PRO SER VAL PHE GLN HIS GLY ASP ASN SER PHE ARG LEU SEQRES 24 B 580 LEU PHE ASP VAL VAL VAL ILE LEU THR CYS SER LEU SER SEQRES 25 B 580 PHE LEU LEU CYS ALA ARG SER LEU LEU ARG GLY PHE LEU SEQRES 26 B 580 LEU GLN ASN GLU PHE VAL GLY PHE MET TRP ARG GLN ARG SEQRES 27 B 580 GLY ARG VAL ILE SER LEU TRP GLU ARG LEU GLU PHE VAL SEQRES 28 B 580 ASN GLY TRP TYR ILE LEU LEU VAL THR SER ASP VAL LEU SEQRES 29 B 580 THR ILE SER GLY THR ILE MET LYS ILE GLY ILE GLU ALA SEQRES 30 B 580 LYS ASN LEU ALA SER TYR ASP VAL CYS SER ILE LEU LEU SEQRES 31 B 580 GLY THR SER THR LEU LEU VAL TRP VAL GLY VAL ILE ARG SEQRES 32 B 580 TYR LEU THR PHE PHE HIS ASN TYR ASN ILE LEU ILE ALA SEQRES 33 B 580 THR LEU ARG VAL ALA LEU PRO SER VAL MET ARG PHE CYS SEQRES 34 B 580 CYS CYS VAL ALA VAL ILE TYR LEU GLY TYR CYS PHE CYS SEQRES 35 B 580 GLY TRP ILE VAL LEU GLY PRO TYR HIS VAL LYS PHE ARG SEQRES 36 B 580 SER LEU SER MET VAL SER GLU CYS LEU PHE SER LEU ILE SEQRES 37 B 580 ASN GLY ASP ASP MET PHE VAL THR PHE ALA ALA MET GLN SEQRES 38 B 580 ALA GLN GLN GLY ARG SER SER LEU VAL TRP LEU PHE SER SEQRES 39 B 580 GLN LEU TYR LEU TYR SER PHE ILE SER LEU PHE ILE TYR SEQRES 40 B 580 MET VAL LEU SER LEU PHE ILE ALA LEU ILE THR GLY ALA SEQRES 41 B 580 TYR ASP THR ILE LYS HIS PRO GLY GLY ALA GLY ALA GLU SEQRES 42 B 580 GLU SER GLU LEU GLN ALA TYR ILE ALA GLN CYS GLN ASP SEQRES 43 B 580 SER PRO THR SER GLY LYS PHE ARG ARG GLY SER GLY SER SEQRES 44 B 580 ALA CYS SER LEU LEU CYS CYS CYS GLY ARG ASP PRO SER SEQRES 45 B 580 GLU GLU HIS SER LEU LEU VAL ASN SEQRES 1 C 580 MET THR ALA PRO ALA GLY PRO ARG GLY SER GLU THR GLU SEQRES 2 C 580 ARG LEU LEU THR PRO ASN PRO GLY TYR GLY THR GLN ALA SEQRES 3 C 580 GLY PRO SER PRO ALA PRO PRO THR PRO PRO GLU GLU GLU SEQRES 4 C 580 ASP LEU ARG ARG ARG LEU LYS TYR PHE PHE MET SER PRO SEQRES 5 C 580 CYS ASP LYS PHE ARG ALA LYS GLY ARG LYS PRO CYS LYS SEQRES 6 C 580 LEU MET LEU GLN VAL VAL LYS ILE LEU VAL VAL THR VAL SEQRES 7 C 580 GLN LEU ILE LEU PHE GLY LEU SER ASN GLN LEU ALA VAL SEQRES 8 C 580 THR PHE ARG GLU GLU ASN THR ILE ALA PHE ARG HIS LEU SEQRES 9 C 580 PHE LEU LEU GLY TYR SER ASP GLY ALA ASP ASP THR PHE SEQRES 10 C 580 ALA ALA TYR THR ARG GLU GLN LEU TYR GLN ALA ILE PHE SEQRES 11 C 580 HIS ALA VAL ASP GLN TYR LEU ALA LEU PRO ASP VAL SER SEQRES 12 C 580 LEU GLY ARG TYR ALA TYR VAL ARG GLY GLY GLY ASP PRO SEQRES 13 C 580 TRP THR ASN GLY SER GLY LEU ALA LEU CYS GLN ARG TYR SEQRES 14 C 580 TYR HIS ARG GLY HIS VAL ASP PRO ALA ASN ASP THR PHE SEQRES 15 C 580 ASP ILE ASP PRO MET VAL VAL THR ASP CYS ILE GLN VAL SEQRES 16 C 580 ASP PRO PRO GLU ARG PRO PRO PRO PRO PRO SER ASP ASP SEQRES 17 C 580 LEU THR LEU LEU GLU SER SER SER SER TYR LYS ASN LEU SEQRES 18 C 580 THR LEU LYS PHE HIS LYS LEU VAL ASN VAL THR ILE HIS SEQRES 19 C 580 PHE ARG LEU LYS THR ILE ASN LEU GLN SER LEU ILE ASN SEQRES 20 C 580 ASN GLU ILE PRO ASP CYS TYR THR PHE SER VAL LEU ILE SEQRES 21 C 580 THR PHE ASP ASN LYS ALA HIS SER GLY ARG ILE PRO ILE SEQRES 22 C 580 SER LEU GLU THR GLN ALA HIS ILE GLN GLU CYS LYS HIS SEQRES 23 C 580 PRO SER VAL PHE GLN HIS GLY ASP ASN SER PHE ARG LEU SEQRES 24 C 580 LEU PHE ASP VAL VAL VAL ILE LEU THR CYS SER LEU SER SEQRES 25 C 580 PHE LEU LEU CYS ALA ARG SER LEU LEU ARG GLY PHE LEU SEQRES 26 C 580 LEU GLN ASN GLU PHE VAL GLY PHE MET TRP ARG GLN ARG SEQRES 27 C 580 GLY ARG VAL ILE SER LEU TRP GLU ARG LEU GLU PHE VAL SEQRES 28 C 580 ASN GLY TRP TYR ILE LEU LEU VAL THR SER ASP VAL LEU SEQRES 29 C 580 THR ILE SER GLY THR ILE MET LYS ILE GLY ILE GLU ALA SEQRES 30 C 580 LYS ASN LEU ALA SER TYR ASP VAL CYS SER ILE LEU LEU SEQRES 31 C 580 GLY THR SER THR LEU LEU VAL TRP VAL GLY VAL ILE ARG SEQRES 32 C 580 TYR LEU THR PHE PHE HIS ASN TYR ASN ILE LEU ILE ALA SEQRES 33 C 580 THR LEU ARG VAL ALA LEU PRO SER VAL MET ARG PHE CYS SEQRES 34 C 580 CYS CYS VAL ALA VAL ILE TYR LEU GLY TYR CYS PHE CYS SEQRES 35 C 580 GLY TRP ILE VAL LEU GLY PRO TYR HIS VAL LYS PHE ARG SEQRES 36 C 580 SER LEU SER MET VAL SER GLU CYS LEU PHE SER LEU ILE SEQRES 37 C 580 ASN GLY ASP ASP MET PHE VAL THR PHE ALA ALA MET GLN SEQRES 38 C 580 ALA GLN GLN GLY ARG SER SER LEU VAL TRP LEU PHE SER SEQRES 39 C 580 GLN LEU TYR LEU TYR SER PHE ILE SER LEU PHE ILE TYR SEQRES 40 C 580 MET VAL LEU SER LEU PHE ILE ALA LEU ILE THR GLY ALA SEQRES 41 C 580 TYR ASP THR ILE LYS HIS PRO GLY GLY ALA GLY ALA GLU SEQRES 42 C 580 GLU SER GLU LEU GLN ALA TYR ILE ALA GLN CYS GLN ASP SEQRES 43 C 580 SER PRO THR SER GLY LYS PHE ARG ARG GLY SER GLY SER SEQRES 44 C 580 ALA CYS SER LEU LEU CYS CYS CYS GLY ARG ASP PRO SER SEQRES 45 C 580 GLU GLU HIS SER LEU LEU VAL ASN SEQRES 1 D 580 MET THR ALA PRO ALA GLY PRO ARG GLY SER GLU THR GLU SEQRES 2 D 580 ARG LEU LEU THR PRO ASN PRO GLY TYR GLY THR GLN ALA SEQRES 3 D 580 GLY PRO SER PRO ALA PRO PRO THR PRO PRO GLU GLU GLU SEQRES 4 D 580 ASP LEU ARG ARG ARG LEU LYS TYR PHE PHE MET SER PRO SEQRES 5 D 580 CYS ASP LYS PHE ARG ALA LYS GLY ARG LYS PRO CYS LYS SEQRES 6 D 580 LEU MET LEU GLN VAL VAL LYS ILE LEU VAL VAL THR VAL SEQRES 7 D 580 GLN LEU ILE LEU PHE GLY LEU SER ASN GLN LEU ALA VAL SEQRES 8 D 580 THR PHE ARG GLU GLU ASN THR ILE ALA PHE ARG HIS LEU SEQRES 9 D 580 PHE LEU LEU GLY TYR SER ASP GLY ALA ASP ASP THR PHE SEQRES 10 D 580 ALA ALA TYR THR ARG GLU GLN LEU TYR GLN ALA ILE PHE SEQRES 11 D 580 HIS ALA VAL ASP GLN TYR LEU ALA LEU PRO ASP VAL SER SEQRES 12 D 580 LEU GLY ARG TYR ALA TYR VAL ARG GLY GLY GLY ASP PRO SEQRES 13 D 580 TRP THR ASN GLY SER GLY LEU ALA LEU CYS GLN ARG TYR SEQRES 14 D 580 TYR HIS ARG GLY HIS VAL ASP PRO ALA ASN ASP THR PHE SEQRES 15 D 580 ASP ILE ASP PRO MET VAL VAL THR ASP CYS ILE GLN VAL SEQRES 16 D 580 ASP PRO PRO GLU ARG PRO PRO PRO PRO PRO SER ASP ASP SEQRES 17 D 580 LEU THR LEU LEU GLU SER SER SER SER TYR LYS ASN LEU SEQRES 18 D 580 THR LEU LYS PHE HIS LYS LEU VAL ASN VAL THR ILE HIS SEQRES 19 D 580 PHE ARG LEU LYS THR ILE ASN LEU GLN SER LEU ILE ASN SEQRES 20 D 580 ASN GLU ILE PRO ASP CYS TYR THR PHE SER VAL LEU ILE SEQRES 21 D 580 THR PHE ASP ASN LYS ALA HIS SER GLY ARG ILE PRO ILE SEQRES 22 D 580 SER LEU GLU THR GLN ALA HIS ILE GLN GLU CYS LYS HIS SEQRES 23 D 580 PRO SER VAL PHE GLN HIS GLY ASP ASN SER PHE ARG LEU SEQRES 24 D 580 LEU PHE ASP VAL VAL VAL ILE LEU THR CYS SER LEU SER SEQRES 25 D 580 PHE LEU LEU CYS ALA ARG SER LEU LEU ARG GLY PHE LEU SEQRES 26 D 580 LEU GLN ASN GLU PHE VAL GLY PHE MET TRP ARG GLN ARG SEQRES 27 D 580 GLY ARG VAL ILE SER LEU TRP GLU ARG LEU GLU PHE VAL SEQRES 28 D 580 ASN GLY TRP TYR ILE LEU LEU VAL THR SER ASP VAL LEU SEQRES 29 D 580 THR ILE SER GLY THR ILE MET LYS ILE GLY ILE GLU ALA SEQRES 30 D 580 LYS ASN LEU ALA SER TYR ASP VAL CYS SER ILE LEU LEU SEQRES 31 D 580 GLY THR SER THR LEU LEU VAL TRP VAL GLY VAL ILE ARG SEQRES 32 D 580 TYR LEU THR PHE PHE HIS ASN TYR ASN ILE LEU ILE ALA SEQRES 33 D 580 THR LEU ARG VAL ALA LEU PRO SER VAL MET ARG PHE CYS SEQRES 34 D 580 CYS CYS VAL ALA VAL ILE TYR LEU GLY TYR CYS PHE CYS SEQRES 35 D 580 GLY TRP ILE VAL LEU GLY PRO TYR HIS VAL LYS PHE ARG SEQRES 36 D 580 SER LEU SER MET VAL SER GLU CYS LEU PHE SER LEU ILE SEQRES 37 D 580 ASN GLY ASP ASP MET PHE VAL THR PHE ALA ALA MET GLN SEQRES 38 D 580 ALA GLN GLN GLY ARG SER SER LEU VAL TRP LEU PHE SER SEQRES 39 D 580 GLN LEU TYR LEU TYR SER PHE ILE SER LEU PHE ILE TYR SEQRES 40 D 580 MET VAL LEU SER LEU PHE ILE ALA LEU ILE THR GLY ALA SEQRES 41 D 580 TYR ASP THR ILE LYS HIS PRO GLY GLY ALA GLY ALA GLU SEQRES 42 D 580 GLU SER GLU LEU GLN ALA TYR ILE ALA GLN CYS GLN ASP SEQRES 43 D 580 SER PRO THR SER GLY LYS PHE ARG ARG GLY SER GLY SER SEQRES 44 D 580 ALA CYS SER LEU LEU CYS CYS CYS GLY ARG ASP PRO SER SEQRES 45 D 580 GLU GLU HIS SER LEU LEU VAL ASN HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HET NAG L 1 14 HET NAG L 2 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 9 NAG 8(C8 H15 N O6) HELIX 1 AA1 PRO E 32 HIS E 36 5 5 HELIX 2 AA2 LYS E 91 THR E 95 5 5 HELIX 3 AA3 CYS A 64 LEU A 106 1 43 HELIX 4 AA4 THR A 121 SER A 143 1 23 HELIX 5 AA5 ASP A 208 LEU A 212 5 5 HELIX 6 AA6 GLU A 213 LEU A 221 5 9 HELIX 7 AA7 LYS A 224 HIS A 226 5 3 HELIX 8 AA8 ASN A 241 ASN A 247 1 7 HELIX 9 AA9 ARG A 298 ARG A 322 1 25 HELIX 10 AB1 GLY A 353 GLY A 374 1 22 HELIX 11 AB2 ALA A 381 VAL A 401 1 21 HELIX 12 AB3 VAL A 401 THR A 406 1 6 HELIX 13 AB4 PHE A 408 GLY A 448 1 41 HELIX 14 AB5 HIS A 451 ARG A 455 5 5 HELIX 15 AB6 SER A 456 GLY A 470 1 15 HELIX 16 AB7 ASP A 472 ALA A 482 1 11 HELIX 17 AB8 SER A 487 MET A 508 1 22 HELIX 18 AB9 MET A 508 LYS A 525 1 18 HELIX 19 AC1 PRO F 32 HIS F 36 5 5 HELIX 20 AC2 LYS F 91 THR F 95 5 5 HELIX 21 AC3 PRO G 32 HIS G 36 5 5 HELIX 22 AC4 LYS G 91 THR G 95 5 5 HELIX 23 AC5 PRO H 32 HIS H 36 5 5 HELIX 24 AC6 LYS H 91 THR H 95 5 5 HELIX 25 AC7 CYS B 64 LEU B 106 1 43 HELIX 26 AC8 THR B 121 SER B 143 1 23 HELIX 27 AC9 ASP B 208 LEU B 212 5 5 HELIX 28 AD1 GLU B 213 LEU B 221 5 9 HELIX 29 AD2 LYS B 224 HIS B 226 5 3 HELIX 30 AD3 ASN B 241 ASN B 247 1 7 HELIX 31 AD4 ARG B 298 ARG B 322 1 25 HELIX 32 AD5 GLY B 353 GLY B 374 1 22 HELIX 33 AD6 ALA B 381 VAL B 401 1 21 HELIX 34 AD7 VAL B 401 THR B 406 1 6 HELIX 35 AD8 PHE B 408 GLY B 448 1 41 HELIX 36 AD9 HIS B 451 ARG B 455 5 5 HELIX 37 AE1 SER B 456 GLY B 470 1 15 HELIX 38 AE2 ASP B 472 ALA B 482 1 11 HELIX 39 AE3 SER B 487 MET B 508 1 22 HELIX 40 AE4 MET B 508 LYS B 525 1 18 HELIX 41 AE5 CYS C 64 LEU C 106 1 43 HELIX 42 AE6 THR C 121 SER C 143 1 23 HELIX 43 AE7 ASP C 208 LEU C 212 5 5 HELIX 44 AE8 GLU C 213 LEU C 221 5 9 HELIX 45 AE9 LYS C 224 HIS C 226 5 3 HELIX 46 AF1 ASN C 241 ASN C 247 1 7 HELIX 47 AF2 ARG C 298 ARG C 322 1 25 HELIX 48 AF3 GLY C 353 GLY C 374 1 22 HELIX 49 AF4 ALA C 381 VAL C 401 1 21 HELIX 50 AF5 VAL C 401 THR C 406 1 6 HELIX 51 AF6 PHE C 408 GLY C 448 1 41 HELIX 52 AF7 HIS C 451 ARG C 455 5 5 HELIX 53 AF8 SER C 456 GLY C 470 1 15 HELIX 54 AF9 ASP C 472 ALA C 482 1 11 HELIX 55 AG1 SER C 487 MET C 508 1 22 HELIX 56 AG2 MET C 508 LYS C 525 1 18 HELIX 57 AG3 CYS D 64 LEU D 106 1 43 HELIX 58 AG4 THR D 121 SER D 143 1 23 HELIX 59 AG5 ASP D 208 LEU D 212 5 5 HELIX 60 AG6 GLU D 213 LEU D 221 5 9 HELIX 61 AG7 LYS D 224 HIS D 226 5 3 HELIX 62 AG8 ASN D 241 ASN D 247 1 7 HELIX 63 AG9 ARG D 298 ARG D 322 1 25 HELIX 64 AH1 GLY D 353 GLY D 374 1 22 HELIX 65 AH2 ALA D 381 VAL D 401 1 21 HELIX 66 AH3 VAL D 401 THR D 406 1 6 HELIX 67 AH4 PHE D 408 GLY D 448 1 41 HELIX 68 AH5 HIS D 451 ARG D 455 5 5 HELIX 69 AH6 SER D 456 GLY D 470 1 15 HELIX 70 AH7 ASP D 472 ALA D 482 1 11 HELIX 71 AH8 SER D 487 MET D 508 1 22 HELIX 72 AH9 MET D 508 LYS D 525 1 18 SHEET 1 AA1 4 GLN E 7 SER E 11 0 SHEET 2 AA1 4 LEU E 22 SER E 29 -1 O ALA E 27 N VAL E 9 SHEET 3 AA1 4 THR E 82 MET E 87 -1 O MET E 87 N LEU E 22 SHEET 4 AA1 4 PHE E 72 ASP E 77 -1 N SER E 75 O TYR E 84 SHEET 1 AA2 5 THR E 62 TYR E 64 0 SHEET 2 AA2 5 ARG E 49 ILE E 55 -1 N ALA E 54 O GLU E 63 SHEET 3 AA2 5 PHE E 37 GLN E 43 -1 N ARG E 42 O GLU E 50 SHEET 4 AA2 5 ALA E 96 MET E 103 -1 O TYR E 101 N ARG E 39 SHEET 5 AA2 5 TRP E 107 HIS E 109 -1 O TYR E 108 N VAL E 102 SHEET 1 AA3 5 THR E 62 TYR E 64 0 SHEET 2 AA3 5 ARG E 49 ILE E 55 -1 N ALA E 54 O GLU E 63 SHEET 3 AA3 5 PHE E 37 GLN E 43 -1 N ARG E 42 O GLU E 50 SHEET 4 AA3 5 ALA E 96 MET E 103 -1 O TYR E 101 N ARG E 39 SHEET 5 AA3 5 THR E 113 VAL E 115 -1 O THR E 113 N TYR E 98 SHEET 1 AA4 5 ALA A 118 ALA A 119 0 SHEET 2 AA4 5 ILE A 271 GLU A 283 -1 O ILE A 271 N ALA A 119 SHEET 3 AA4 5 ASP A 252 ASP A 263 -1 N CYS A 253 O GLN A 282 SHEET 4 AA4 5 LEU A 228 ILE A 240 -1 N THR A 239 O TYR A 254 SHEET 5 AA4 5 ALA A 148 TYR A 149 -1 N ALA A 148 O LYS A 238 SHEET 1 AA5 6 ALA A 118 ALA A 119 0 SHEET 2 AA5 6 ILE A 271 GLU A 283 -1 O ILE A 271 N ALA A 119 SHEET 3 AA5 6 ASP A 252 ASP A 263 -1 N CYS A 253 O GLN A 282 SHEET 4 AA5 6 LEU A 228 ILE A 240 -1 N THR A 239 O TYR A 254 SHEET 5 AA5 6 LEU A 163 TYR A 170 -1 N ARG A 168 O VAL A 229 SHEET 6 AA5 6 VAL A 188 VAL A 195 -1 O VAL A 189 N TYR A 169 SHEET 1 AA6 2 GLY A 173 ASP A 176 0 SHEET 2 AA6 2 THR A 181 ILE A 184 -1 O THR A 181 N ASP A 176 SHEET 1 AA7 4 GLN F 7 SER F 11 0 SHEET 2 AA7 4 LEU F 22 SER F 29 -1 O ALA F 27 N VAL F 9 SHEET 3 AA7 4 THR F 82 MET F 87 -1 O MET F 87 N LEU F 22 SHEET 4 AA7 4 PHE F 72 ASP F 77 -1 N SER F 75 O TYR F 84 SHEET 1 AA8 5 THR F 62 TYR F 64 0 SHEET 2 AA8 5 ARG F 49 ILE F 55 -1 N ALA F 54 O GLU F 63 SHEET 3 AA8 5 PHE F 37 GLN F 43 -1 N ARG F 42 O GLU F 50 SHEET 4 AA8 5 ALA F 96 MET F 103 -1 O TYR F 101 N ARG F 39 SHEET 5 AA8 5 TRP F 107 HIS F 109 -1 O TYR F 108 N VAL F 102 SHEET 1 AA9 5 THR F 62 TYR F 64 0 SHEET 2 AA9 5 ARG F 49 ILE F 55 -1 N ALA F 54 O GLU F 63 SHEET 3 AA9 5 PHE F 37 GLN F 43 -1 N ARG F 42 O GLU F 50 SHEET 4 AA9 5 ALA F 96 MET F 103 -1 O TYR F 101 N ARG F 39 SHEET 5 AA9 5 THR F 113 VAL F 115 -1 O THR F 113 N TYR F 98 SHEET 1 AB1 4 GLN G 7 SER G 11 0 SHEET 2 AB1 4 LEU G 22 SER G 29 -1 O ALA G 27 N VAL G 9 SHEET 3 AB1 4 THR G 82 MET G 87 -1 O MET G 87 N LEU G 22 SHEET 4 AB1 4 PHE G 72 ASP G 77 -1 N SER G 75 O TYR G 84 SHEET 1 AB2 5 THR G 62 TYR G 64 0 SHEET 2 AB2 5 ARG G 49 ILE G 55 -1 N ALA G 54 O GLU G 63 SHEET 3 AB2 5 PHE G 37 GLN G 43 -1 N ARG G 42 O GLU G 50 SHEET 4 AB2 5 ALA G 96 MET G 103 -1 O TYR G 101 N ARG G 39 SHEET 5 AB2 5 TRP G 107 HIS G 109 -1 O TYR G 108 N VAL G 102 SHEET 1 AB3 5 THR G 62 TYR G 64 0 SHEET 2 AB3 5 ARG G 49 ILE G 55 -1 N ALA G 54 O GLU G 63 SHEET 3 AB3 5 PHE G 37 GLN G 43 -1 N ARG G 42 O GLU G 50 SHEET 4 AB3 5 ALA G 96 MET G 103 -1 O TYR G 101 N ARG G 39 SHEET 5 AB3 5 THR G 113 VAL G 115 -1 O THR G 113 N TYR G 98 SHEET 1 AB4 4 GLN H 7 SER H 11 0 SHEET 2 AB4 4 LEU H 22 SER H 29 -1 O ALA H 27 N VAL H 9 SHEET 3 AB4 4 THR H 82 MET H 87 -1 O MET H 87 N LEU H 22 SHEET 4 AB4 4 PHE H 72 ASP H 77 -1 N SER H 75 O TYR H 84 SHEET 1 AB5 5 THR H 62 TYR H 64 0 SHEET 2 AB5 5 ARG H 49 ILE H 55 -1 N ALA H 54 O GLU H 63 SHEET 3 AB5 5 PHE H 37 GLN H 43 -1 N ARG H 42 O GLU H 50 SHEET 4 AB5 5 ALA H 96 MET H 103 -1 O TYR H 101 N ARG H 39 SHEET 5 AB5 5 TRP H 107 HIS H 109 -1 O TYR H 108 N VAL H 102 SHEET 1 AB6 5 THR H 62 TYR H 64 0 SHEET 2 AB6 5 ARG H 49 ILE H 55 -1 N ALA H 54 O GLU H 63 SHEET 3 AB6 5 PHE H 37 GLN H 43 -1 N ARG H 42 O GLU H 50 SHEET 4 AB6 5 ALA H 96 MET H 103 -1 O TYR H 101 N ARG H 39 SHEET 5 AB6 5 THR H 113 VAL H 115 -1 O THR H 113 N TYR H 98 SHEET 1 AB7 5 ALA B 118 ALA B 119 0 SHEET 2 AB7 5 ILE B 271 GLU B 283 -1 O ILE B 271 N ALA B 119 SHEET 3 AB7 5 ASP B 252 ASP B 263 -1 N CYS B 253 O GLN B 282 SHEET 4 AB7 5 LEU B 228 ILE B 240 -1 N THR B 239 O TYR B 254 SHEET 5 AB7 5 ALA B 148 TYR B 149 -1 N ALA B 148 O LYS B 238 SHEET 1 AB8 6 ALA B 118 ALA B 119 0 SHEET 2 AB8 6 ILE B 271 GLU B 283 -1 O ILE B 271 N ALA B 119 SHEET 3 AB8 6 ASP B 252 ASP B 263 -1 N CYS B 253 O GLN B 282 SHEET 4 AB8 6 LEU B 228 ILE B 240 -1 N THR B 239 O TYR B 254 SHEET 5 AB8 6 LEU B 163 TYR B 170 -1 N ARG B 168 O VAL B 229 SHEET 6 AB8 6 VAL B 188 VAL B 195 -1 O VAL B 189 N TYR B 169 SHEET 1 AB9 2 GLY B 173 ASP B 176 0 SHEET 2 AB9 2 THR B 181 ILE B 184 -1 O THR B 181 N ASP B 176 SHEET 1 AC1 5 ALA C 118 ALA C 119 0 SHEET 2 AC1 5 ILE C 271 GLU C 283 -1 O ILE C 271 N ALA C 119 SHEET 3 AC1 5 ASP C 252 ASP C 263 -1 N CYS C 253 O GLN C 282 SHEET 4 AC1 5 LEU C 228 ILE C 240 -1 N THR C 239 O TYR C 254 SHEET 5 AC1 5 ALA C 148 TYR C 149 -1 N ALA C 148 O LYS C 238 SHEET 1 AC2 6 ALA C 118 ALA C 119 0 SHEET 2 AC2 6 ILE C 271 GLU C 283 -1 O ILE C 271 N ALA C 119 SHEET 3 AC2 6 ASP C 252 ASP C 263 -1 N CYS C 253 O GLN C 282 SHEET 4 AC2 6 LEU C 228 ILE C 240 -1 N THR C 239 O TYR C 254 SHEET 5 AC2 6 LEU C 163 TYR C 170 -1 N ARG C 168 O VAL C 229 SHEET 6 AC2 6 VAL C 188 VAL C 195 -1 O VAL C 189 N TYR C 169 SHEET 1 AC3 2 GLY C 173 ASP C 176 0 SHEET 2 AC3 2 THR C 181 ILE C 184 -1 O THR C 181 N ASP C 176 SHEET 1 AC4 5 ALA D 118 ALA D 119 0 SHEET 2 AC4 5 ILE D 271 GLU D 283 -1 O ILE D 271 N ALA D 119 SHEET 3 AC4 5 ASP D 252 ASP D 263 -1 N CYS D 253 O GLN D 282 SHEET 4 AC4 5 LEU D 228 ILE D 240 -1 N THR D 239 O TYR D 254 SHEET 5 AC4 5 ALA D 148 TYR D 149 -1 N ALA D 148 O LYS D 238 SHEET 1 AC5 6 ALA D 118 ALA D 119 0 SHEET 2 AC5 6 ILE D 271 GLU D 283 -1 O ILE D 271 N ALA D 119 SHEET 3 AC5 6 ASP D 252 ASP D 263 -1 N CYS D 253 O GLN D 282 SHEET 4 AC5 6 LEU D 228 ILE D 240 -1 N THR D 239 O TYR D 254 SHEET 5 AC5 6 LEU D 163 TYR D 170 -1 N ARG D 168 O VAL D 229 SHEET 6 AC5 6 VAL D 188 VAL D 195 -1 O VAL D 189 N TYR D 169 SHEET 1 AC6 2 GLY D 173 ASP D 176 0 SHEET 2 AC6 2 THR D 181 ILE D 184 -1 O THR D 181 N ASP D 176 LINK ND2 ASN A 220 C1 NAG I 1 1555 1555 1.44 LINK ND2 ASN B 220 C1 NAG J 1 1555 1555 1.44 LINK ND2 ASN C 220 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN D 220 C1 NAG L 1 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.45 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.45 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.45 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000