HEADER MEMBRANE PROTEIN 23-MAY-24 9FFL TITLE CRYO-EM STRUCTURE OF THE ALPHA1BETA3 GABA(A) RECEPTOR IN COMPLEX WITH TITLE 2 GABA AND MB25 IN THE SHORT-LIVED SYMMETRIC PRE-ACTIVE STATE COMPND MOL_ID: 1; COMPND 2 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1; COMPND 3 CHAIN: D, A; COMPND 4 SYNONYM: GABA(A) RECEPTOR SUBUNIT ALPHA-1; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3; COMPND 8 CHAIN: E, B, C; COMPND 9 SYNONYM: GABA(A) RECEPTOR SUBUNIT BETA-3; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: MEGABODY25,OUTER MEMBRANE PROTEIN; COMPND 13 CHAIN: F; COMPND 14 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: GABRA1; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: EXPI 293F; SOURCE 9 EXPRESSION_SYSTEM_PLASMID: PHLSEC; SOURCE 10 MOL_ID: 2; SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 12 ORGANISM_COMMON: HUMAN; SOURCE 13 ORGANISM_TAXID: 9606; SOURCE 14 GENE: GABRB3; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 17 EXPRESSION_SYSTEM_CELL_LINE: EXPI 293F; SOURCE 18 EXPRESSION_SYSTEM_PLASMID: PHLSEC; SOURCE 19 MOL_ID: 3; SOURCE 20 ORGANISM_SCIENTIFIC: LAMA GLAMA, HELICOBACTER PYLORI G27; SOURCE 21 ORGANISM_TAXID: 9844, 563041; SOURCE 22 GENE: HOPQ, HPG27_1120; SOURCE 23 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 24 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 25 EXPRESSION_SYSTEM_STRAIN: WK6 SU- KEYWDS GABA, NEUROTRANSMISSION, GATING CYCLE, TIME-RESOLVED CRYO-EM, KEYWDS 2 MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR D.B.MIHAYLOV,T.MALINAUSKAS,A.R.ARICESCU REVDAT 1 04-JUN-25 9FFL 0 JRNL AUTH D.B.MIHAYLOV,T.MALINAUSKAS,A.R.ARICESCU JRNL TITL CRYO-EM STRUCTURE OF THE ALPHA1BETA3 GABA(A) RECEPTOR IN JRNL TITL 2 COMPLEX WITH GABA AND MB25 IN THE SHORT-LIVED SYMMETRIC JRNL TITL 3 PRE-ACTIVE STATE JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.80 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : TOPAZ, EPU, CTFFIND, PHENIX, PHENIX, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 6HUK REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : OTHER REMARK 3 REFINEMENT TARGET : FSC AT 0.5 REMARK 3 OVERALL ANISOTROPIC B VALUE : 30.000 REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.800 REMARK 3 NUMBER OF PARTICLES : 176000 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9FFL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 23-MAY-24. REMARK 100 THE DEPOSITION ID IS D_1292138634. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF THE REMARK 245 ALPHA1BETA3 GABA(A) RECEPTOR IN REMARK 245 COMPLEX WITH GABA AND MB25 IN REMARK 245 THE SHORT-LIVED SYMMETRIC PRE- REMARK 245 ACTIVE STATE REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.00 REMARK 245 SAMPLE SUPPORT DETAILS : CURRENT: 30MA REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 18399 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : TFS FALCON 4I (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1400.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 96000 REMARK 245 CALIBRATED MAGNIFICATION : 96000 REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, E, B, A, C, F, a, b, G, c, REMARK 350 AND CHAINS: H, d, e, I REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET D -52 REMARK 465 ASP D -51 REMARK 465 GLU D -50 REMARK 465 LYS D -49 REMARK 465 THR D -48 REMARK 465 THR D -47 REMARK 465 GLY D -46 REMARK 465 TRP D -45 REMARK 465 ARG D -44 REMARK 465 GLY D -43 REMARK 465 GLY D -42 REMARK 465 HIS D -41 REMARK 465 VAL D -40 REMARK 465 VAL D -39 REMARK 465 GLU D -38 REMARK 465 GLY D -37 REMARK 465 LEU D -36 REMARK 465 ALA D -35 REMARK 465 GLY D -34 REMARK 465 GLU D -33 REMARK 465 LEU D -32 REMARK 465 GLU D -31 REMARK 465 GLN D -30 REMARK 465 LEU D -29 REMARK 465 ARG D -28 REMARK 465 ALA D -27 REMARK 465 ARG D -26 REMARK 465 LEU D -25 REMARK 465 GLU D -24 REMARK 465 HIS D -23 REMARK 465 HIS D -22 REMARK 465 PRO D -21 REMARK 465 GLN D -20 REMARK 465 GLY D -19 REMARK 465 GLN D -18 REMARK 465 ARG D -17 REMARK 465 GLU D -16 REMARK 465 PRO D -15 REMARK 465 ASP D -14 REMARK 465 TYR D -13 REMARK 465 ASP D -12 REMARK 465 ILE D -11 REMARK 465 PRO D -10 REMARK 465 THR D -9 REMARK 465 THR D -8 REMARK 465 GLU D -7 REMARK 465 ASN D -6 REMARK 465 LEU D -5 REMARK 465 TYR D -4 REMARK 465 PHE D -3 REMARK 465 GLN D -2 REMARK 465 GLY D -1 REMARK 465 THR D 0 REMARK 465 GLY D 1 REMARK 465 GLN D 2 REMARK 465 PRO D 3 REMARK 465 SER D 4 REMARK 465 GLN D 5 REMARK 465 ASP D 6 REMARK 465 GLU D 7 REMARK 465 LEU D 8 REMARK 465 LYS D 9 REMARK 465 ASP D 10 REMARK 465 ASN D 11 REMARK 465 GLU D 419 REMARK 465 PRO D 420 REMARK 465 GLN D 421 REMARK 465 LEU D 422 REMARK 465 LYS D 423 REMARK 465 ALA D 424 REMARK 465 PRO D 425 REMARK 465 THR D 426 REMARK 465 PRO D 427 REMARK 465 HIS D 428 REMARK 465 GLN D 429 REMARK 465 MET E -53 REMARK 465 ASP E -52 REMARK 465 GLU E -51 REMARK 465 LYS E -50 REMARK 465 THR E -49 REMARK 465 THR E -48 REMARK 465 GLY E -47 REMARK 465 TRP E -46 REMARK 465 ARG E -45 REMARK 465 GLY E -44 REMARK 465 GLY E -43 REMARK 465 HIS E -42 REMARK 465 VAL E -41 REMARK 465 VAL E -40 REMARK 465 GLU E -39 REMARK 465 GLY E -38 REMARK 465 LEU E -37 REMARK 465 ALA E -36 REMARK 465 GLY E -35 REMARK 465 GLU E -34 REMARK 465 LEU E -33 REMARK 465 GLU E -32 REMARK 465 GLN E -31 REMARK 465 LEU E -30 REMARK 465 ARG E -29 REMARK 465 ALA E -28 REMARK 465 ARG E -27 REMARK 465 LEU E -26 REMARK 465 GLU E -25 REMARK 465 HIS E -24 REMARK 465 HIS E -23 REMARK 465 PRO E -22 REMARK 465 GLN E -21 REMARK 465 GLY E -20 REMARK 465 GLN E -19 REMARK 465 ARG E -18 REMARK 465 GLU E -17 REMARK 465 PRO E -16 REMARK 465 ASP E -15 REMARK 465 TYR E -14 REMARK 465 ASP E -13 REMARK 465 ILE E -12 REMARK 465 PRO E -11 REMARK 465 THR E -10 REMARK 465 THR E -9 REMARK 465 GLU E -8 REMARK 465 ASN E -7 REMARK 465 LEU E -6 REMARK 465 TYR E -5 REMARK 465 PHE E -4 REMARK 465 GLN E -3 REMARK 465 GLY E -2 REMARK 465 THR E -1 REMARK 465 GLY E 0 REMARK 465 GLN E 1 REMARK 465 SER E 2 REMARK 465 VAL E 3 REMARK 465 ASN E 4 REMARK 465 ASP E 5 REMARK 465 PRO E 6 REMARK 465 GLY E 7 REMARK 465 ASN E 448 REMARK 465 MET B -53 REMARK 465 ASP B -52 REMARK 465 GLU B -51 REMARK 465 LYS B -50 REMARK 465 THR B -49 REMARK 465 THR B -48 REMARK 465 GLY B -47 REMARK 465 TRP B -46 REMARK 465 ARG B -45 REMARK 465 GLY B -44 REMARK 465 GLY B -43 REMARK 465 HIS B -42 REMARK 465 VAL B -41 REMARK 465 VAL B -40 REMARK 465 GLU B -39 REMARK 465 GLY B -38 REMARK 465 LEU B -37 REMARK 465 ALA B -36 REMARK 465 GLY B -35 REMARK 465 GLU B -34 REMARK 465 LEU B -33 REMARK 465 GLU B -32 REMARK 465 GLN B -31 REMARK 465 LEU B -30 REMARK 465 ARG B -29 REMARK 465 ALA B -28 REMARK 465 ARG B -27 REMARK 465 LEU B -26 REMARK 465 GLU B -25 REMARK 465 HIS B -24 REMARK 465 HIS B -23 REMARK 465 PRO B -22 REMARK 465 GLN B -21 REMARK 465 GLY B -20 REMARK 465 GLN B -19 REMARK 465 ARG B -18 REMARK 465 GLU B -17 REMARK 465 PRO B -16 REMARK 465 ASP B -15 REMARK 465 TYR B -14 REMARK 465 ASP B -13 REMARK 465 ILE B -12 REMARK 465 PRO B -11 REMARK 465 THR B -10 REMARK 465 THR B -9 REMARK 465 GLU B -8 REMARK 465 ASN B -7 REMARK 465 LEU B -6 REMARK 465 TYR B -5 REMARK 465 PHE B -4 REMARK 465 GLN B -3 REMARK 465 GLY B -2 REMARK 465 THR B -1 REMARK 465 GLY B 0 REMARK 465 GLN B 1 REMARK 465 SER B 2 REMARK 465 VAL B 3 REMARK 465 ASN B 4 REMARK 465 ASP B 5 REMARK 465 PRO B 6 REMARK 465 GLY B 7 REMARK 465 ASN B 448 REMARK 465 MET A -52 REMARK 465 ASP A -51 REMARK 465 GLU A -50 REMARK 465 LYS A -49 REMARK 465 THR A -48 REMARK 465 THR A -47 REMARK 465 GLY A -46 REMARK 465 TRP A -45 REMARK 465 ARG A -44 REMARK 465 GLY A -43 REMARK 465 GLY A -42 REMARK 465 HIS A -41 REMARK 465 VAL A -40 REMARK 465 VAL A -39 REMARK 465 GLU A -38 REMARK 465 GLY A -37 REMARK 465 LEU A -36 REMARK 465 ALA A -35 REMARK 465 GLY A -34 REMARK 465 GLU A -33 REMARK 465 LEU A -32 REMARK 465 GLU A -31 REMARK 465 GLN A -30 REMARK 465 LEU A -29 REMARK 465 ARG A -28 REMARK 465 ALA A -27 REMARK 465 ARG A -26 REMARK 465 LEU A -25 REMARK 465 GLU A -24 REMARK 465 HIS A -23 REMARK 465 HIS A -22 REMARK 465 PRO A -21 REMARK 465 GLN A -20 REMARK 465 GLY A -19 REMARK 465 GLN A -18 REMARK 465 ARG A -17 REMARK 465 GLU A -16 REMARK 465 PRO A -15 REMARK 465 ASP A -14 REMARK 465 TYR A -13 REMARK 465 ASP A -12 REMARK 465 ILE A -11 REMARK 465 PRO A -10 REMARK 465 THR A -9 REMARK 465 THR A -8 REMARK 465 GLU A -7 REMARK 465 ASN A -6 REMARK 465 LEU A -5 REMARK 465 TYR A -4 REMARK 465 PHE A -3 REMARK 465 GLN A -2 REMARK 465 GLY A -1 REMARK 465 THR A 0 REMARK 465 GLY A 1 REMARK 465 GLN A 2 REMARK 465 PRO A 3 REMARK 465 SER A 4 REMARK 465 GLN A 5 REMARK 465 ASP A 6 REMARK 465 GLU A 7 REMARK 465 LEU A 8 REMARK 465 LYS A 9 REMARK 465 ASP A 10 REMARK 465 ASN A 11 REMARK 465 GLU A 419 REMARK 465 PRO A 420 REMARK 465 GLN A 421 REMARK 465 LEU A 422 REMARK 465 LYS A 423 REMARK 465 ALA A 424 REMARK 465 PRO A 425 REMARK 465 THR A 426 REMARK 465 PRO A 427 REMARK 465 HIS A 428 REMARK 465 GLN A 429 REMARK 465 MET C -53 REMARK 465 ASP C -52 REMARK 465 GLU C -51 REMARK 465 LYS C -50 REMARK 465 THR C -49 REMARK 465 THR C -48 REMARK 465 GLY C -47 REMARK 465 TRP C -46 REMARK 465 ARG C -45 REMARK 465 GLY C -44 REMARK 465 GLY C -43 REMARK 465 HIS C -42 REMARK 465 VAL C -41 REMARK 465 VAL C -40 REMARK 465 GLU C -39 REMARK 465 GLY C -38 REMARK 465 LEU C -37 REMARK 465 ALA C -36 REMARK 465 GLY C -35 REMARK 465 GLU C -34 REMARK 465 LEU C -33 REMARK 465 GLU C -32 REMARK 465 GLN C -31 REMARK 465 LEU C -30 REMARK 465 ARG C -29 REMARK 465 ALA C -28 REMARK 465 ARG C -27 REMARK 465 LEU C -26 REMARK 465 GLU C -25 REMARK 465 HIS C -24 REMARK 465 HIS C -23 REMARK 465 PRO C -22 REMARK 465 GLN C -21 REMARK 465 GLY C -20 REMARK 465 GLN C -19 REMARK 465 ARG C -18 REMARK 465 GLU C -17 REMARK 465 PRO C -16 REMARK 465 ASP C -15 REMARK 465 TYR C -14 REMARK 465 ASP C -13 REMARK 465 ILE C -12 REMARK 465 PRO C -11 REMARK 465 THR C -10 REMARK 465 THR C -9 REMARK 465 GLU C -8 REMARK 465 ASN C -7 REMARK 465 LEU C -6 REMARK 465 TYR C -5 REMARK 465 PHE C -4 REMARK 465 GLN C -3 REMARK 465 GLY C -2 REMARK 465 THR C -1 REMARK 465 GLY C 0 REMARK 465 GLN C 1 REMARK 465 SER C 2 REMARK 465 VAL C 3 REMARK 465 ASN C 4 REMARK 465 ASP C 5 REMARK 465 PRO C 6 REMARK 465 GLY C 7 REMARK 465 ASN C 448 REMARK 465 GLY F 10 REMARK 465 GLY F 11 REMARK 465 LEU F 12 REMARK 465 VAL F 13 REMARK 465 GLN F 14 REMARK 465 THR F 15 REMARK 465 LYS F 16 REMARK 465 THR F 17 REMARK 465 THR F 18 REMARK 465 THR F 19 REMARK 465 SER F 20 REMARK 465 VAL F 21 REMARK 465 ILE F 22 REMARK 465 ASP F 23 REMARK 465 THR F 24 REMARK 465 THR F 25 REMARK 465 ASN F 26 REMARK 465 ASP F 27 REMARK 465 ALA F 28 REMARK 465 GLN F 29 REMARK 465 ASN F 30 REMARK 465 LEU F 31 REMARK 465 LEU F 32 REMARK 465 THR F 33 REMARK 465 GLN F 34 REMARK 465 ALA F 35 REMARK 465 GLN F 36 REMARK 465 THR F 37 REMARK 465 ILE F 38 REMARK 465 VAL F 39 REMARK 465 ASN F 40 REMARK 465 THR F 41 REMARK 465 LEU F 42 REMARK 465 LYS F 43 REMARK 465 ASP F 44 REMARK 465 TYR F 45 REMARK 465 CYS F 46 REMARK 465 PRO F 47 REMARK 465 ILE F 48 REMARK 465 LEU F 49 REMARK 465 ILE F 50 REMARK 465 ALA F 51 REMARK 465 LYS F 52 REMARK 465 SER F 53 REMARK 465 SER F 54 REMARK 465 SER F 55 REMARK 465 SER F 56 REMARK 465 ASN F 57 REMARK 465 GLY F 58 REMARK 465 GLY F 59 REMARK 465 THR F 60 REMARK 465 ASN F 61 REMARK 465 ASN F 62 REMARK 465 ALA F 63 REMARK 465 ASN F 64 REMARK 465 THR F 65 REMARK 465 PRO F 66 REMARK 465 SER F 67 REMARK 465 TRP F 68 REMARK 465 GLN F 69 REMARK 465 THR F 70 REMARK 465 ALA F 71 REMARK 465 GLY F 72 REMARK 465 GLY F 73 REMARK 465 GLY F 74 REMARK 465 LYS F 75 REMARK 465 ASN F 76 REMARK 465 SER F 77 REMARK 465 CYS F 78 REMARK 465 ALA F 79 REMARK 465 THR F 80 REMARK 465 PHE F 81 REMARK 465 GLY F 82 REMARK 465 ALA F 83 REMARK 465 GLU F 84 REMARK 465 PHE F 85 REMARK 465 SER F 86 REMARK 465 ALA F 87 REMARK 465 ALA F 88 REMARK 465 SER F 89 REMARK 465 ASP F 90 REMARK 465 MET F 91 REMARK 465 ILE F 92 REMARK 465 ASN F 93 REMARK 465 ASN F 94 REMARK 465 ALA F 95 REMARK 465 GLN F 96 REMARK 465 LYS F 97 REMARK 465 ILE F 98 REMARK 465 VAL F 99 REMARK 465 GLN F 100 REMARK 465 GLU F 101 REMARK 465 THR F 102 REMARK 465 GLN F 103 REMARK 465 GLN F 104 REMARK 465 LEU F 105 REMARK 465 SER F 106 REMARK 465 ALA F 107 REMARK 465 ASN F 108 REMARK 465 GLN F 109 REMARK 465 PRO F 110 REMARK 465 LYS F 111 REMARK 465 ASN F 112 REMARK 465 ILE F 113 REMARK 465 THR F 114 REMARK 465 GLN F 115 REMARK 465 PRO F 116 REMARK 465 HIS F 117 REMARK 465 ASN F 118 REMARK 465 LEU F 119 REMARK 465 ASN F 120 REMARK 465 LEU F 121 REMARK 465 ASN F 122 REMARK 465 SER F 123 REMARK 465 PRO F 124 REMARK 465 SER F 125 REMARK 465 SER F 126 REMARK 465 LEU F 127 REMARK 465 THR F 128 REMARK 465 ALA F 129 REMARK 465 LEU F 130 REMARK 465 ALA F 131 REMARK 465 GLN F 132 REMARK 465 LYS F 133 REMARK 465 MET F 134 REMARK 465 LEU F 135 REMARK 465 LYS F 136 REMARK 465 ASN F 137 REMARK 465 ALA F 138 REMARK 465 GLN F 139 REMARK 465 SER F 140 REMARK 465 GLN F 141 REMARK 465 ALA F 142 REMARK 465 GLU F 143 REMARK 465 ILE F 144 REMARK 465 LEU F 145 REMARK 465 LYS F 146 REMARK 465 LEU F 147 REMARK 465 ALA F 148 REMARK 465 ASN F 149 REMARK 465 GLN F 150 REMARK 465 VAL F 151 REMARK 465 GLU F 152 REMARK 465 SER F 153 REMARK 465 ASP F 154 REMARK 465 PHE F 155 REMARK 465 ASN F 156 REMARK 465 LYS F 157 REMARK 465 LEU F 158 REMARK 465 SER F 159 REMARK 465 SER F 160 REMARK 465 GLY F 161 REMARK 465 HIS F 162 REMARK 465 LEU F 163 REMARK 465 LYS F 164 REMARK 465 ASP F 165 REMARK 465 TYR F 166 REMARK 465 ILE F 167 REMARK 465 GLY F 168 REMARK 465 LYS F 169 REMARK 465 CYS F 170 REMARK 465 ASP F 171 REMARK 465 ALA F 172 REMARK 465 SER F 173 REMARK 465 ALA F 174 REMARK 465 ILE F 175 REMARK 465 SER F 176 REMARK 465 SER F 177 REMARK 465 ALA F 178 REMARK 465 ASN F 179 REMARK 465 MET F 180 REMARK 465 THR F 181 REMARK 465 MET F 182 REMARK 465 GLN F 183 REMARK 465 ASN F 184 REMARK 465 GLN F 185 REMARK 465 LYS F 186 REMARK 465 ASN F 187 REMARK 465 ASN F 188 REMARK 465 TRP F 189 REMARK 465 GLY F 190 REMARK 465 ASN F 191 REMARK 465 GLY F 192 REMARK 465 CYS F 193 REMARK 465 ALA F 194 REMARK 465 GLY F 195 REMARK 465 VAL F 196 REMARK 465 GLU F 197 REMARK 465 GLU F 198 REMARK 465 THR F 199 REMARK 465 GLN F 200 REMARK 465 SER F 201 REMARK 465 LEU F 202 REMARK 465 LEU F 203 REMARK 465 LYS F 204 REMARK 465 THR F 205 REMARK 465 SER F 206 REMARK 465 ALA F 207 REMARK 465 ALA F 208 REMARK 465 ASP F 209 REMARK 465 PHE F 210 REMARK 465 ASN F 211 REMARK 465 ASN F 212 REMARK 465 GLN F 213 REMARK 465 THR F 214 REMARK 465 PRO F 215 REMARK 465 GLN F 216 REMARK 465 ILE F 217 REMARK 465 ASN F 218 REMARK 465 GLN F 219 REMARK 465 ALA F 220 REMARK 465 GLN F 221 REMARK 465 ASN F 222 REMARK 465 LEU F 223 REMARK 465 ALA F 224 REMARK 465 ASN F 225 REMARK 465 THR F 226 REMARK 465 LEU F 227 REMARK 465 ILE F 228 REMARK 465 GLN F 229 REMARK 465 GLU F 230 REMARK 465 LEU F 231 REMARK 465 GLY F 232 REMARK 465 ASN F 233 REMARK 465 ASN F 234 REMARK 465 THR F 235 REMARK 465 TYR F 236 REMARK 465 GLU F 237 REMARK 465 GLN F 238 REMARK 465 LEU F 239 REMARK 465 SER F 240 REMARK 465 ARG F 241 REMARK 465 LEU F 242 REMARK 465 LEU F 243 REMARK 465 THR F 244 REMARK 465 ASN F 245 REMARK 465 ASP F 246 REMARK 465 ASN F 247 REMARK 465 GLY F 248 REMARK 465 THR F 249 REMARK 465 ASN F 250 REMARK 465 SER F 251 REMARK 465 LYS F 252 REMARK 465 THR F 253 REMARK 465 SER F 254 REMARK 465 ALA F 255 REMARK 465 GLN F 256 REMARK 465 ALA F 257 REMARK 465 ILE F 258 REMARK 465 ASN F 259 REMARK 465 GLN F 260 REMARK 465 ALA F 261 REMARK 465 VAL F 262 REMARK 465 ASN F 263 REMARK 465 ASN F 264 REMARK 465 LEU F 265 REMARK 465 ASN F 266 REMARK 465 GLU F 267 REMARK 465 ARG F 268 REMARK 465 ALA F 269 REMARK 465 LYS F 270 REMARK 465 THR F 271 REMARK 465 LEU F 272 REMARK 465 ALA F 273 REMARK 465 GLY F 274 REMARK 465 GLY F 275 REMARK 465 THR F 276 REMARK 465 THR F 277 REMARK 465 ASN F 278 REMARK 465 SER F 279 REMARK 465 PRO F 280 REMARK 465 ALA F 281 REMARK 465 TYR F 282 REMARK 465 GLN F 283 REMARK 465 ALA F 284 REMARK 465 THR F 285 REMARK 465 LEU F 286 REMARK 465 LEU F 287 REMARK 465 ALA F 288 REMARK 465 LEU F 289 REMARK 465 ARG F 290 REMARK 465 SER F 291 REMARK 465 VAL F 292 REMARK 465 LEU F 293 REMARK 465 GLY F 294 REMARK 465 LEU F 295 REMARK 465 TRP F 296 REMARK 465 ASN F 297 REMARK 465 SER F 298 REMARK 465 MET F 299 REMARK 465 GLY F 300 REMARK 465 TYR F 301 REMARK 465 ALA F 302 REMARK 465 VAL F 303 REMARK 465 ILE F 304 REMARK 465 CYS F 305 REMARK 465 GLY F 306 REMARK 465 GLY F 307 REMARK 465 TYR F 308 REMARK 465 THR F 309 REMARK 465 LYS F 310 REMARK 465 SER F 311 REMARK 465 PRO F 312 REMARK 465 GLY F 313 REMARK 465 GLU F 314 REMARK 465 ASN F 315 REMARK 465 ASN F 316 REMARK 465 GLN F 317 REMARK 465 LYS F 318 REMARK 465 ASP F 319 REMARK 465 PHE F 320 REMARK 465 HIS F 321 REMARK 465 TYR F 322 REMARK 465 THR F 323 REMARK 465 ASP F 324 REMARK 465 GLU F 325 REMARK 465 ASN F 326 REMARK 465 GLY F 327 REMARK 465 ASN F 328 REMARK 465 GLY F 329 REMARK 465 THR F 330 REMARK 465 THR F 331 REMARK 465 ILE F 332 REMARK 465 ASN F 333 REMARK 465 CYS F 334 REMARK 465 GLY F 335 REMARK 465 GLY F 336 REMARK 465 SER F 337 REMARK 465 THR F 338 REMARK 465 ASN F 339 REMARK 465 SER F 340 REMARK 465 ASN F 341 REMARK 465 GLY F 342 REMARK 465 THR F 343 REMARK 465 HIS F 344 REMARK 465 SER F 345 REMARK 465 TYR F 346 REMARK 465 ASN F 347 REMARK 465 GLY F 348 REMARK 465 THR F 349 REMARK 465 ASN F 350 REMARK 465 THR F 351 REMARK 465 LEU F 352 REMARK 465 LYS F 353 REMARK 465 ALA F 354 REMARK 465 ASP F 355 REMARK 465 LYS F 356 REMARK 465 ASN F 357 REMARK 465 VAL F 358 REMARK 465 SER F 359 REMARK 465 LEU F 360 REMARK 465 SER F 361 REMARK 465 ILE F 362 REMARK 465 GLU F 363 REMARK 465 GLN F 364 REMARK 465 TYR F 365 REMARK 465 GLU F 366 REMARK 465 LYS F 367 REMARK 465 ILE F 368 REMARK 465 HIS F 369 REMARK 465 GLU F 370 REMARK 465 ALA F 371 REMARK 465 TYR F 372 REMARK 465 GLN F 373 REMARK 465 ILE F 374 REMARK 465 LEU F 375 REMARK 465 SER F 376 REMARK 465 LYS F 377 REMARK 465 ALA F 378 REMARK 465 LEU F 379 REMARK 465 LYS F 380 REMARK 465 GLN F 381 REMARK 465 ALA F 382 REMARK 465 GLY F 383 REMARK 465 LEU F 384 REMARK 465 ALA F 385 REMARK 465 PRO F 386 REMARK 465 LEU F 387 REMARK 465 ASN F 388 REMARK 465 SER F 389 REMARK 465 LYS F 390 REMARK 465 GLY F 391 REMARK 465 GLU F 392 REMARK 465 LYS F 393 REMARK 465 LEU F 394 REMARK 465 GLU F 395 REMARK 465 ALA F 396 REMARK 465 HIS F 397 REMARK 465 VAL F 398 REMARK 465 THR F 399 REMARK 465 THR F 400 REMARK 465 SER F 401 REMARK 465 LYS F 402 REMARK 465 TYR F 403 REMARK 465 GLY F 404 REMARK 465 SER F 405 REMARK 465 VAL F 511 REMARK 465 SER F 512 REMARK 465 SER F 513 REMARK 465 HIS F 514 REMARK 465 HIS F 515 REMARK 465 HIS F 516 REMARK 465 HIS F 517 REMARK 465 HIS F 518 REMARK 465 HIS F 519 REMARK 465 GLU F 520 REMARK 465 PRO F 521 REMARK 465 GLU F 522 REMARK 465 ALA F 523 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASP D 98 58.74 -98.52 REMARK 500 PRO D 147 36.61 -98.40 REMARK 500 ARG D 173 -158.85 -148.26 REMARK 500 ARG D 187 35.77 -94.13 REMARK 500 PRO E 78 47.65 -78.32 REMARK 500 ASP E 95 53.17 -90.35 REMARK 500 PRO B 78 49.08 -79.27 REMARK 500 LYS B 103 116.54 -161.49 REMARK 500 LEU B 145 34.97 -99.29 REMARK 500 LEU A 143 33.75 -97.76 REMARK 500 PRO A 147 39.17 -98.95 REMARK 500 THR A 230 -51.09 -120.06 REMARK 500 ASN A 417 40.85 -100.09 REMARK 500 LYS C 103 115.49 -164.82 REMARK 500 PRO C 144 41.26 -97.52 REMARK 500 SER F 442 -71.35 -89.53 REMARK 500 ASP F 454 -1.96 67.22 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-50365 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF THE ALPHA1BETA3 GABA(A) RECEPTOR IN COMPLEX REMARK 900 WITH GABA AND MB25 IN THE SHORT-LIVED SYMMETRIC PRE-ACTIVE STATE DBREF 9FFL D 5 312 UNP P14867 GBRA1_HUMAN 32 339 DBREF 9FFL D 391 429 UNP P14867 GBRA1_HUMAN 418 456 DBREF 9FFL E 1 307 UNP P28472 GBRB3_HUMAN 26 332 DBREF 9FFL E 422 448 UNP P28472 GBRB3_HUMAN 447 473 DBREF 9FFL B 1 307 UNP P28472 GBRB3_HUMAN 26 332 DBREF 9FFL B 422 448 UNP P28472 GBRB3_HUMAN 447 473 DBREF 9FFL A 5 312 UNP P14867 GBRA1_HUMAN 32 339 DBREF 9FFL A 391 429 UNP P14867 GBRA1_HUMAN 418 456 DBREF 9FFL C 1 307 UNP P28472 GBRB3_HUMAN 26 332 DBREF 9FFL C 422 448 UNP P28472 GBRB3_HUMAN 447 473 DBREF 9FFL F 2 13 PDB 9FFL 9FFL 2 13 DBREF 9FFL F 14 234 UNP B5Z8H1 B5Z8H1_HELPG 226 446 DBREF 9FFL F 235 403 UNP B5Z8H1 B5Z8H1_HELPG 53 221 DBREF 9FFL F 404 523 PDB 9FFL 9FFL 404 523 SEQADV 9FFL MET D -52 UNP P14867 INITIATING METHIONINE SEQADV 9FFL ASP D -51 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU D -50 UNP P14867 EXPRESSION TAG SEQADV 9FFL LYS D -49 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR D -48 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR D -47 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D -46 UNP P14867 EXPRESSION TAG SEQADV 9FFL TRP D -45 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG D -44 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D -43 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D -42 UNP P14867 EXPRESSION TAG SEQADV 9FFL HIS D -41 UNP P14867 EXPRESSION TAG SEQADV 9FFL VAL D -40 UNP P14867 EXPRESSION TAG SEQADV 9FFL VAL D -39 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU D -38 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D -37 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU D -36 UNP P14867 EXPRESSION TAG SEQADV 9FFL ALA D -35 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D -34 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU D -33 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU D -32 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU D -31 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN D -30 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU D -29 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG D -28 UNP P14867 EXPRESSION TAG SEQADV 9FFL ALA D -27 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG D -26 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU D -25 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU D -24 UNP P14867 EXPRESSION TAG SEQADV 9FFL HIS D -23 UNP P14867 EXPRESSION TAG SEQADV 9FFL HIS D -22 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO D -21 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN D -20 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D -19 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN D -18 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG D -17 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU D -16 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO D -15 UNP P14867 EXPRESSION TAG SEQADV 9FFL ASP D -14 UNP P14867 EXPRESSION TAG SEQADV 9FFL TYR D -13 UNP P14867 EXPRESSION TAG SEQADV 9FFL ASP D -12 UNP P14867 EXPRESSION TAG SEQADV 9FFL ILE D -11 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO D -10 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR D -9 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR D -8 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU D -7 UNP P14867 EXPRESSION TAG SEQADV 9FFL ASN D -6 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU D -5 UNP P14867 EXPRESSION TAG SEQADV 9FFL TYR D -4 UNP P14867 EXPRESSION TAG SEQADV 9FFL PHE D -3 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN D -2 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D -1 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR D 0 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY D 1 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN D 2 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO D 3 UNP P14867 EXPRESSION TAG SEQADV 9FFL SER D 4 UNP P14867 EXPRESSION TAG SEQADV 9FFL SER D 313 UNP P14867 LINKER SEQADV 9FFL GLN D 385 UNP P14867 LINKER SEQADV 9FFL PRO D 386 UNP P14867 LINKER SEQADV 9FFL ALA D 387 UNP P14867 LINKER SEQADV 9FFL ARG D 388 UNP P14867 LINKER SEQADV 9FFL ALA D 389 UNP P14867 LINKER SEQADV 9FFL ALA D 390 UNP P14867 LINKER SEQADV 9FFL MET E -53 UNP P28472 INITIATING METHIONINE SEQADV 9FFL ASP E -52 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU E -51 UNP P28472 EXPRESSION TAG SEQADV 9FFL LYS E -50 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR E -49 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR E -48 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E -47 UNP P28472 EXPRESSION TAG SEQADV 9FFL TRP E -46 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG E -45 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E -44 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E -43 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS E -42 UNP P28472 EXPRESSION TAG SEQADV 9FFL VAL E -41 UNP P28472 EXPRESSION TAG SEQADV 9FFL VAL E -40 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU E -39 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E -38 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU E -37 UNP P28472 EXPRESSION TAG SEQADV 9FFL ALA E -36 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E -35 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU E -34 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU E -33 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU E -32 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN E -31 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU E -30 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG E -29 UNP P28472 EXPRESSION TAG SEQADV 9FFL ALA E -28 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG E -27 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU E -26 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU E -25 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS E -24 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS E -23 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO E -22 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN E -21 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E -20 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN E -19 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG E -18 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU E -17 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO E -16 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASP E -15 UNP P28472 EXPRESSION TAG SEQADV 9FFL TYR E -14 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASP E -13 UNP P28472 EXPRESSION TAG SEQADV 9FFL ILE E -12 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO E -11 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR E -10 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR E -9 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU E -8 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASN E -7 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU E -6 UNP P28472 EXPRESSION TAG SEQADV 9FFL TYR E -5 UNP P28472 EXPRESSION TAG SEQADV 9FFL PHE E -4 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN E -3 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E -2 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR E -1 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY E 0 UNP P28472 EXPRESSION TAG SEQADV 9FFL SER E 308 UNP P28472 LINKER SEQADV 9FFL GLN E 309 UNP P28472 LINKER SEQADV 9FFL PRO E 310 UNP P28472 LINKER SEQADV 9FFL ALA E 311 UNP P28472 LINKER SEQADV 9FFL ARG E 312 UNP P28472 LINKER SEQADV 9FFL ALA E 313 UNP P28472 LINKER SEQADV 9FFL ALA E 314 UNP P28472 LINKER SEQADV 9FFL MET B -53 UNP P28472 INITIATING METHIONINE SEQADV 9FFL ASP B -52 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU B -51 UNP P28472 EXPRESSION TAG SEQADV 9FFL LYS B -50 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR B -49 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR B -48 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B -47 UNP P28472 EXPRESSION TAG SEQADV 9FFL TRP B -46 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG B -45 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B -44 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B -43 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS B -42 UNP P28472 EXPRESSION TAG SEQADV 9FFL VAL B -41 UNP P28472 EXPRESSION TAG SEQADV 9FFL VAL B -40 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU B -39 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B -38 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU B -37 UNP P28472 EXPRESSION TAG SEQADV 9FFL ALA B -36 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B -35 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU B -34 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU B -33 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU B -32 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN B -31 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU B -30 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG B -29 UNP P28472 EXPRESSION TAG SEQADV 9FFL ALA B -28 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG B -27 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU B -26 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU B -25 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS B -24 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS B -23 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO B -22 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN B -21 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B -20 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN B -19 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG B -18 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU B -17 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO B -16 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASP B -15 UNP P28472 EXPRESSION TAG SEQADV 9FFL TYR B -14 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASP B -13 UNP P28472 EXPRESSION TAG SEQADV 9FFL ILE B -12 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO B -11 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR B -10 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR B -9 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU B -8 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASN B -7 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU B -6 UNP P28472 EXPRESSION TAG SEQADV 9FFL TYR B -5 UNP P28472 EXPRESSION TAG SEQADV 9FFL PHE B -4 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN B -3 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B -2 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR B -1 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY B 0 UNP P28472 EXPRESSION TAG SEQADV 9FFL SER B 308 UNP P28472 LINKER SEQADV 9FFL GLN B 309 UNP P28472 LINKER SEQADV 9FFL PRO B 310 UNP P28472 LINKER SEQADV 9FFL ALA B 311 UNP P28472 LINKER SEQADV 9FFL ARG B 312 UNP P28472 LINKER SEQADV 9FFL ALA B 313 UNP P28472 LINKER SEQADV 9FFL ALA B 314 UNP P28472 LINKER SEQADV 9FFL MET A -52 UNP P14867 INITIATING METHIONINE SEQADV 9FFL ASP A -51 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU A -50 UNP P14867 EXPRESSION TAG SEQADV 9FFL LYS A -49 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR A -48 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR A -47 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A -46 UNP P14867 EXPRESSION TAG SEQADV 9FFL TRP A -45 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG A -44 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A -43 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A -42 UNP P14867 EXPRESSION TAG SEQADV 9FFL HIS A -41 UNP P14867 EXPRESSION TAG SEQADV 9FFL VAL A -40 UNP P14867 EXPRESSION TAG SEQADV 9FFL VAL A -39 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU A -38 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A -37 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU A -36 UNP P14867 EXPRESSION TAG SEQADV 9FFL ALA A -35 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A -34 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU A -33 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU A -32 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU A -31 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN A -30 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU A -29 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG A -28 UNP P14867 EXPRESSION TAG SEQADV 9FFL ALA A -27 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG A -26 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU A -25 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU A -24 UNP P14867 EXPRESSION TAG SEQADV 9FFL HIS A -23 UNP P14867 EXPRESSION TAG SEQADV 9FFL HIS A -22 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO A -21 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN A -20 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A -19 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN A -18 UNP P14867 EXPRESSION TAG SEQADV 9FFL ARG A -17 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU A -16 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO A -15 UNP P14867 EXPRESSION TAG SEQADV 9FFL ASP A -14 UNP P14867 EXPRESSION TAG SEQADV 9FFL TYR A -13 UNP P14867 EXPRESSION TAG SEQADV 9FFL ASP A -12 UNP P14867 EXPRESSION TAG SEQADV 9FFL ILE A -11 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO A -10 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR A -9 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR A -8 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLU A -7 UNP P14867 EXPRESSION TAG SEQADV 9FFL ASN A -6 UNP P14867 EXPRESSION TAG SEQADV 9FFL LEU A -5 UNP P14867 EXPRESSION TAG SEQADV 9FFL TYR A -4 UNP P14867 EXPRESSION TAG SEQADV 9FFL PHE A -3 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN A -2 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A -1 UNP P14867 EXPRESSION TAG SEQADV 9FFL THR A 0 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLY A 1 UNP P14867 EXPRESSION TAG SEQADV 9FFL GLN A 2 UNP P14867 EXPRESSION TAG SEQADV 9FFL PRO A 3 UNP P14867 EXPRESSION TAG SEQADV 9FFL SER A 4 UNP P14867 EXPRESSION TAG SEQADV 9FFL SER A 313 UNP P14867 LINKER SEQADV 9FFL GLN A 385 UNP P14867 LINKER SEQADV 9FFL PRO A 386 UNP P14867 LINKER SEQADV 9FFL ALA A 387 UNP P14867 LINKER SEQADV 9FFL ARG A 388 UNP P14867 LINKER SEQADV 9FFL ALA A 389 UNP P14867 LINKER SEQADV 9FFL ALA A 390 UNP P14867 LINKER SEQADV 9FFL MET C -53 UNP P28472 INITIATING METHIONINE SEQADV 9FFL ASP C -52 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU C -51 UNP P28472 EXPRESSION TAG SEQADV 9FFL LYS C -50 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR C -49 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR C -48 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C -47 UNP P28472 EXPRESSION TAG SEQADV 9FFL TRP C -46 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG C -45 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C -44 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C -43 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS C -42 UNP P28472 EXPRESSION TAG SEQADV 9FFL VAL C -41 UNP P28472 EXPRESSION TAG SEQADV 9FFL VAL C -40 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU C -39 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C -38 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU C -37 UNP P28472 EXPRESSION TAG SEQADV 9FFL ALA C -36 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C -35 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU C -34 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU C -33 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU C -32 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN C -31 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU C -30 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG C -29 UNP P28472 EXPRESSION TAG SEQADV 9FFL ALA C -28 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG C -27 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU C -26 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU C -25 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS C -24 UNP P28472 EXPRESSION TAG SEQADV 9FFL HIS C -23 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO C -22 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN C -21 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C -20 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN C -19 UNP P28472 EXPRESSION TAG SEQADV 9FFL ARG C -18 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU C -17 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO C -16 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASP C -15 UNP P28472 EXPRESSION TAG SEQADV 9FFL TYR C -14 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASP C -13 UNP P28472 EXPRESSION TAG SEQADV 9FFL ILE C -12 UNP P28472 EXPRESSION TAG SEQADV 9FFL PRO C -11 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR C -10 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR C -9 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLU C -8 UNP P28472 EXPRESSION TAG SEQADV 9FFL ASN C -7 UNP P28472 EXPRESSION TAG SEQADV 9FFL LEU C -6 UNP P28472 EXPRESSION TAG SEQADV 9FFL TYR C -5 UNP P28472 EXPRESSION TAG SEQADV 9FFL PHE C -4 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLN C -3 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C -2 UNP P28472 EXPRESSION TAG SEQADV 9FFL THR C -1 UNP P28472 EXPRESSION TAG SEQADV 9FFL GLY C 0 UNP P28472 EXPRESSION TAG SEQADV 9FFL SER C 308 UNP P28472 LINKER SEQADV 9FFL GLN C 309 UNP P28472 LINKER SEQADV 9FFL PRO C 310 UNP P28472 LINKER SEQADV 9FFL ALA C 311 UNP P28472 LINKER SEQADV 9FFL ARG C 312 UNP P28472 LINKER SEQADV 9FFL ALA C 313 UNP P28472 LINKER SEQADV 9FFL ALA C 314 UNP P28472 LINKER SEQRES 1 D 411 MET ASP GLU LYS THR THR GLY TRP ARG GLY GLY HIS VAL SEQRES 2 D 411 VAL GLU GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA SEQRES 3 D 411 ARG LEU GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ASP SEQRES 4 D 411 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY SEQRES 5 D 411 THR GLY GLN PRO SER GLN ASP GLU LEU LYS ASP ASN THR SEQRES 6 D 411 THR VAL PHE THR ARG ILE LEU ASP ARG LEU LEU ASP GLY SEQRES 7 D 411 TYR ASP ASN ARG LEU ARG PRO GLY LEU GLY GLU ARG VAL SEQRES 8 D 411 THR GLU VAL LYS THR ASP ILE PHE VAL THR SER PHE GLY SEQRES 9 D 411 PRO VAL SER ASP HIS ASP MET GLU TYR THR ILE ASP VAL SEQRES 10 D 411 PHE PHE ARG GLN SER TRP LYS ASP GLU ARG LEU LYS PHE SEQRES 11 D 411 LYS GLY PRO MET THR VAL LEU ARG LEU ASN ASN LEU MET SEQRES 12 D 411 ALA SER LYS ILE TRP THR PRO ASP THR PHE PHE HIS ASN SEQRES 13 D 411 GLY LYS LYS SER VAL ALA HIS ASN MET THR MET PRO ASN SEQRES 14 D 411 LYS LEU LEU ARG ILE THR GLU ASP GLY THR LEU LEU TYR SEQRES 15 D 411 THR MET ARG LEU THR VAL ARG ALA GLU CYS PRO MET HIS SEQRES 16 D 411 LEU GLU ASP PHE PRO MET ASP ALA HIS ALA CYS PRO LEU SEQRES 17 D 411 LYS PHE GLY SER TYR ALA TYR THR ARG ALA GLU VAL VAL SEQRES 18 D 411 TYR GLU TRP THR ARG GLU PRO ALA ARG SER VAL VAL VAL SEQRES 19 D 411 ALA GLU ASP GLY SER ARG LEU ASN GLN TYR ASP LEU LEU SEQRES 20 D 411 GLY GLN THR VAL ASP SER GLY ILE VAL GLN SER SER THR SEQRES 21 D 411 GLY GLU TYR VAL VAL MET THR THR HIS PHE HIS LEU LYS SEQRES 22 D 411 ARG LYS ILE GLY TYR PHE VAL ILE GLN THR TYR LEU PRO SEQRES 23 D 411 CYS ILE MET THR VAL ILE LEU SER GLN VAL SER PHE TRP SEQRES 24 D 411 LEU ASN ARG GLU SER VAL PRO ALA ARG THR VAL PHE GLY SEQRES 25 D 411 VAL THR THR VAL LEU THR MET THR THR LEU SER ILE SER SEQRES 26 D 411 ALA ARG ASN SER LEU PRO LYS VAL ALA TYR ALA THR ALA SEQRES 27 D 411 MET ASP TRP PHE ILE ALA VAL CYS TYR ALA PHE VAL PHE SEQRES 28 D 411 SER ALA LEU ILE GLU PHE ALA THR VAL ASN TYR PHE THR SEQRES 29 D 411 LYS SER GLN PRO ALA ARG ALA ALA LYS ILE ASP ARG LEU SEQRES 30 D 411 SER ARG ILE ALA PHE PRO LEU LEU PHE GLY ILE PHE ASN SEQRES 31 D 411 LEU VAL TYR TRP ALA THR TYR LEU ASN ARG GLU PRO GLN SEQRES 32 D 411 LEU LYS ALA PRO THR PRO HIS GLN SEQRES 1 E 395 MET ASP GLU LYS THR THR GLY TRP ARG GLY GLY HIS VAL SEQRES 2 E 395 VAL GLU GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA SEQRES 3 E 395 ARG LEU GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ASP SEQRES 4 E 395 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY SEQRES 5 E 395 THR GLY GLN SER VAL ASN ASP PRO GLY ASN MET SER PHE SEQRES 6 E 395 VAL LYS GLU THR VAL ASP LYS LEU LEU LYS GLY TYR ASP SEQRES 7 E 395 ILE ARG LEU ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS SEQRES 8 E 395 VAL GLY MET ASN ILE ASP ILE ALA SER ILE ASP MET VAL SEQRES 9 E 395 SER GLU VAL ASN MET ASP TYR THR LEU THR MET TYR PHE SEQRES 10 E 395 GLN GLN TYR TRP ARG ASP LYS ARG LEU ALA TYR SER GLY SEQRES 11 E 395 ILE PRO LEU ASN LEU THR LEU ASP ASN ARG VAL ALA ASP SEQRES 12 E 395 GLN LEU TRP VAL PRO ASP THR TYR PHE LEU ASN ASP LYS SEQRES 13 E 395 LYS SER PHE VAL HIS GLY VAL THR VAL LYS ASN ARG MET SEQRES 14 E 395 ILE ARG LEU HIS PRO ASP GLY THR VAL LEU TYR GLY LEU SEQRES 15 E 395 ARG ILE THR THR THR ALA ALA CYS MET MET ASP LEU ARG SEQRES 16 E 395 ARG TYR PRO LEU ASP GLU GLN ASN CYS THR LEU GLU ILE SEQRES 17 E 395 GLU SER TYR GLY TYR THR THR ASP ASP ILE GLU PHE TYR SEQRES 18 E 395 TRP ARG GLY GLY ASP LYS ALA VAL THR GLY VAL GLU ARG SEQRES 19 E 395 ILE GLU LEU PRO GLN PHE SER ILE VAL GLU HIS ARG LEU SEQRES 20 E 395 VAL SER ARG ASN VAL VAL PHE ALA THR GLY ALA TYR PRO SEQRES 21 E 395 ARG LEU SER LEU SER PHE ARG LEU LYS ARG ASN ILE GLY SEQRES 22 E 395 TYR PHE ILE LEU GLN THR TYR MET PRO SER ILE LEU ILE SEQRES 23 E 395 THR ILE LEU SER TRP VAL SER PHE TRP ILE ASN TYR ASP SEQRES 24 E 395 ALA SER ALA ALA ARG VAL ALA LEU GLY ILE THR THR VAL SEQRES 25 E 395 LEU THR MET THR THR ILE ASN THR HIS LEU ARG GLU THR SEQRES 26 E 395 LEU PRO LYS ILE PRO TYR VAL LYS ALA ILE ASP MET TYR SEQRES 27 E 395 LEU MET GLY CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU SEQRES 28 E 395 GLU TYR ALA PHE VAL ASN TYR ILE PHE PHE SER GLN PRO SEQRES 29 E 395 ALA ARG ALA ALA ALA ILE ASP ARG TRP SER ARG ILE VAL SEQRES 30 E 395 PHE PRO PHE THR PHE SER LEU PHE ASN LEU VAL TYR TRP SEQRES 31 E 395 LEU TYR TYR VAL ASN SEQRES 1 B 395 MET ASP GLU LYS THR THR GLY TRP ARG GLY GLY HIS VAL SEQRES 2 B 395 VAL GLU GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA SEQRES 3 B 395 ARG LEU GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ASP SEQRES 4 B 395 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY SEQRES 5 B 395 THR GLY GLN SER VAL ASN ASP PRO GLY ASN MET SER PHE SEQRES 6 B 395 VAL LYS GLU THR VAL ASP LYS LEU LEU LYS GLY TYR ASP SEQRES 7 B 395 ILE ARG LEU ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS SEQRES 8 B 395 VAL GLY MET ASN ILE ASP ILE ALA SER ILE ASP MET VAL SEQRES 9 B 395 SER GLU VAL ASN MET ASP TYR THR LEU THR MET TYR PHE SEQRES 10 B 395 GLN GLN TYR TRP ARG ASP LYS ARG LEU ALA TYR SER GLY SEQRES 11 B 395 ILE PRO LEU ASN LEU THR LEU ASP ASN ARG VAL ALA ASP SEQRES 12 B 395 GLN LEU TRP VAL PRO ASP THR TYR PHE LEU ASN ASP LYS SEQRES 13 B 395 LYS SER PHE VAL HIS GLY VAL THR VAL LYS ASN ARG MET SEQRES 14 B 395 ILE ARG LEU HIS PRO ASP GLY THR VAL LEU TYR GLY LEU SEQRES 15 B 395 ARG ILE THR THR THR ALA ALA CYS MET MET ASP LEU ARG SEQRES 16 B 395 ARG TYR PRO LEU ASP GLU GLN ASN CYS THR LEU GLU ILE SEQRES 17 B 395 GLU SER TYR GLY TYR THR THR ASP ASP ILE GLU PHE TYR SEQRES 18 B 395 TRP ARG GLY GLY ASP LYS ALA VAL THR GLY VAL GLU ARG SEQRES 19 B 395 ILE GLU LEU PRO GLN PHE SER ILE VAL GLU HIS ARG LEU SEQRES 20 B 395 VAL SER ARG ASN VAL VAL PHE ALA THR GLY ALA TYR PRO SEQRES 21 B 395 ARG LEU SER LEU SER PHE ARG LEU LYS ARG ASN ILE GLY SEQRES 22 B 395 TYR PHE ILE LEU GLN THR TYR MET PRO SER ILE LEU ILE SEQRES 23 B 395 THR ILE LEU SER TRP VAL SER PHE TRP ILE ASN TYR ASP SEQRES 24 B 395 ALA SER ALA ALA ARG VAL ALA LEU GLY ILE THR THR VAL SEQRES 25 B 395 LEU THR MET THR THR ILE ASN THR HIS LEU ARG GLU THR SEQRES 26 B 395 LEU PRO LYS ILE PRO TYR VAL LYS ALA ILE ASP MET TYR SEQRES 27 B 395 LEU MET GLY CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU SEQRES 28 B 395 GLU TYR ALA PHE VAL ASN TYR ILE PHE PHE SER GLN PRO SEQRES 29 B 395 ALA ARG ALA ALA ALA ILE ASP ARG TRP SER ARG ILE VAL SEQRES 30 B 395 PHE PRO PHE THR PHE SER LEU PHE ASN LEU VAL TYR TRP SEQRES 31 B 395 LEU TYR TYR VAL ASN SEQRES 1 A 411 MET ASP GLU LYS THR THR GLY TRP ARG GLY GLY HIS VAL SEQRES 2 A 411 VAL GLU GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA SEQRES 3 A 411 ARG LEU GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ASP SEQRES 4 A 411 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY SEQRES 5 A 411 THR GLY GLN PRO SER GLN ASP GLU LEU LYS ASP ASN THR SEQRES 6 A 411 THR VAL PHE THR ARG ILE LEU ASP ARG LEU LEU ASP GLY SEQRES 7 A 411 TYR ASP ASN ARG LEU ARG PRO GLY LEU GLY GLU ARG VAL SEQRES 8 A 411 THR GLU VAL LYS THR ASP ILE PHE VAL THR SER PHE GLY SEQRES 9 A 411 PRO VAL SER ASP HIS ASP MET GLU TYR THR ILE ASP VAL SEQRES 10 A 411 PHE PHE ARG GLN SER TRP LYS ASP GLU ARG LEU LYS PHE SEQRES 11 A 411 LYS GLY PRO MET THR VAL LEU ARG LEU ASN ASN LEU MET SEQRES 12 A 411 ALA SER LYS ILE TRP THR PRO ASP THR PHE PHE HIS ASN SEQRES 13 A 411 GLY LYS LYS SER VAL ALA HIS ASN MET THR MET PRO ASN SEQRES 14 A 411 LYS LEU LEU ARG ILE THR GLU ASP GLY THR LEU LEU TYR SEQRES 15 A 411 THR MET ARG LEU THR VAL ARG ALA GLU CYS PRO MET HIS SEQRES 16 A 411 LEU GLU ASP PHE PRO MET ASP ALA HIS ALA CYS PRO LEU SEQRES 17 A 411 LYS PHE GLY SER TYR ALA TYR THR ARG ALA GLU VAL VAL SEQRES 18 A 411 TYR GLU TRP THR ARG GLU PRO ALA ARG SER VAL VAL VAL SEQRES 19 A 411 ALA GLU ASP GLY SER ARG LEU ASN GLN TYR ASP LEU LEU SEQRES 20 A 411 GLY GLN THR VAL ASP SER GLY ILE VAL GLN SER SER THR SEQRES 21 A 411 GLY GLU TYR VAL VAL MET THR THR HIS PHE HIS LEU LYS SEQRES 22 A 411 ARG LYS ILE GLY TYR PHE VAL ILE GLN THR TYR LEU PRO SEQRES 23 A 411 CYS ILE MET THR VAL ILE LEU SER GLN VAL SER PHE TRP SEQRES 24 A 411 LEU ASN ARG GLU SER VAL PRO ALA ARG THR VAL PHE GLY SEQRES 25 A 411 VAL THR THR VAL LEU THR MET THR THR LEU SER ILE SER SEQRES 26 A 411 ALA ARG ASN SER LEU PRO LYS VAL ALA TYR ALA THR ALA SEQRES 27 A 411 MET ASP TRP PHE ILE ALA VAL CYS TYR ALA PHE VAL PHE SEQRES 28 A 411 SER ALA LEU ILE GLU PHE ALA THR VAL ASN TYR PHE THR SEQRES 29 A 411 LYS SER GLN PRO ALA ARG ALA ALA LYS ILE ASP ARG LEU SEQRES 30 A 411 SER ARG ILE ALA PHE PRO LEU LEU PHE GLY ILE PHE ASN SEQRES 31 A 411 LEU VAL TYR TRP ALA THR TYR LEU ASN ARG GLU PRO GLN SEQRES 32 A 411 LEU LYS ALA PRO THR PRO HIS GLN SEQRES 1 C 395 MET ASP GLU LYS THR THR GLY TRP ARG GLY GLY HIS VAL SEQRES 2 C 395 VAL GLU GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA SEQRES 3 C 395 ARG LEU GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ASP SEQRES 4 C 395 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY SEQRES 5 C 395 THR GLY GLN SER VAL ASN ASP PRO GLY ASN MET SER PHE SEQRES 6 C 395 VAL LYS GLU THR VAL ASP LYS LEU LEU LYS GLY TYR ASP SEQRES 7 C 395 ILE ARG LEU ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS SEQRES 8 C 395 VAL GLY MET ASN ILE ASP ILE ALA SER ILE ASP MET VAL SEQRES 9 C 395 SER GLU VAL ASN MET ASP TYR THR LEU THR MET TYR PHE SEQRES 10 C 395 GLN GLN TYR TRP ARG ASP LYS ARG LEU ALA TYR SER GLY SEQRES 11 C 395 ILE PRO LEU ASN LEU THR LEU ASP ASN ARG VAL ALA ASP SEQRES 12 C 395 GLN LEU TRP VAL PRO ASP THR TYR PHE LEU ASN ASP LYS SEQRES 13 C 395 LYS SER PHE VAL HIS GLY VAL THR VAL LYS ASN ARG MET SEQRES 14 C 395 ILE ARG LEU HIS PRO ASP GLY THR VAL LEU TYR GLY LEU SEQRES 15 C 395 ARG ILE THR THR THR ALA ALA CYS MET MET ASP LEU ARG SEQRES 16 C 395 ARG TYR PRO LEU ASP GLU GLN ASN CYS THR LEU GLU ILE SEQRES 17 C 395 GLU SER TYR GLY TYR THR THR ASP ASP ILE GLU PHE TYR SEQRES 18 C 395 TRP ARG GLY GLY ASP LYS ALA VAL THR GLY VAL GLU ARG SEQRES 19 C 395 ILE GLU LEU PRO GLN PHE SER ILE VAL GLU HIS ARG LEU SEQRES 20 C 395 VAL SER ARG ASN VAL VAL PHE ALA THR GLY ALA TYR PRO SEQRES 21 C 395 ARG LEU SER LEU SER PHE ARG LEU LYS ARG ASN ILE GLY SEQRES 22 C 395 TYR PHE ILE LEU GLN THR TYR MET PRO SER ILE LEU ILE SEQRES 23 C 395 THR ILE LEU SER TRP VAL SER PHE TRP ILE ASN TYR ASP SEQRES 24 C 395 ALA SER ALA ALA ARG VAL ALA LEU GLY ILE THR THR VAL SEQRES 25 C 395 LEU THR MET THR THR ILE ASN THR HIS LEU ARG GLU THR SEQRES 26 C 395 LEU PRO LYS ILE PRO TYR VAL LYS ALA ILE ASP MET TYR SEQRES 27 C 395 LEU MET GLY CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU SEQRES 28 C 395 GLU TYR ALA PHE VAL ASN TYR ILE PHE PHE SER GLN PRO SEQRES 29 C 395 ALA ARG ALA ALA ALA ILE ASP ARG TRP SER ARG ILE VAL SEQRES 30 C 395 PHE PRO PHE THR PHE SER LEU PHE ASN LEU VAL TYR TRP SEQRES 31 C 395 LEU TYR TYR VAL ASN SEQRES 1 F 522 GLN VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 F 522 THR LYS THR THR THR SER VAL ILE ASP THR THR ASN ASP SEQRES 3 F 522 ALA GLN ASN LEU LEU THR GLN ALA GLN THR ILE VAL ASN SEQRES 4 F 522 THR LEU LYS ASP TYR CYS PRO ILE LEU ILE ALA LYS SER SEQRES 5 F 522 SER SER SER ASN GLY GLY THR ASN ASN ALA ASN THR PRO SEQRES 6 F 522 SER TRP GLN THR ALA GLY GLY GLY LYS ASN SER CYS ALA SEQRES 7 F 522 THR PHE GLY ALA GLU PHE SER ALA ALA SER ASP MET ILE SEQRES 8 F 522 ASN ASN ALA GLN LYS ILE VAL GLN GLU THR GLN GLN LEU SEQRES 9 F 522 SER ALA ASN GLN PRO LYS ASN ILE THR GLN PRO HIS ASN SEQRES 10 F 522 LEU ASN LEU ASN SER PRO SER SER LEU THR ALA LEU ALA SEQRES 11 F 522 GLN LYS MET LEU LYS ASN ALA GLN SER GLN ALA GLU ILE SEQRES 12 F 522 LEU LYS LEU ALA ASN GLN VAL GLU SER ASP PHE ASN LYS SEQRES 13 F 522 LEU SER SER GLY HIS LEU LYS ASP TYR ILE GLY LYS CYS SEQRES 14 F 522 ASP ALA SER ALA ILE SER SER ALA ASN MET THR MET GLN SEQRES 15 F 522 ASN GLN LYS ASN ASN TRP GLY ASN GLY CYS ALA GLY VAL SEQRES 16 F 522 GLU GLU THR GLN SER LEU LEU LYS THR SER ALA ALA ASP SEQRES 17 F 522 PHE ASN ASN GLN THR PRO GLN ILE ASN GLN ALA GLN ASN SEQRES 18 F 522 LEU ALA ASN THR LEU ILE GLN GLU LEU GLY ASN ASN THR SEQRES 19 F 522 TYR GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY SEQRES 20 F 522 THR ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA SEQRES 21 F 522 VAL ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY SEQRES 22 F 522 GLY THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU SEQRES 23 F 522 ALA LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY SEQRES 24 F 522 TYR ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY SEQRES 25 F 522 GLU ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN SEQRES 26 F 522 GLY ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SEQRES 27 F 522 SER ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU SEQRES 28 F 522 LYS ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR SEQRES 29 F 522 GLU LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA SEQRES 30 F 522 LEU LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY SEQRES 31 F 522 GLU LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SEQRES 32 F 522 SER LEU ARG LEU SER CYS ALA ALA SER GLY HIS THR PHE SEQRES 33 F 522 ASN TYR PRO ILE MET GLY TRP PHE ARG GLN ALA PRO GLY SEQRES 34 F 522 LYS GLU ARG GLU PHE VAL GLY ALA ILE SER TRP SER GLY SEQRES 35 F 522 GLY SER THR SER TYR ALA ASP SER VAL LYS ASP ARG PHE SEQRES 36 F 522 THR ILE SER ARG ASP ASN ALA LYS ASN THR VAL TYR LEU SEQRES 37 F 522 GLU MET ASN ASN LEU LYS PRO GLU ASP THR ALA VAL TYR SEQRES 38 F 522 TYR CYS ALA ALA LYS GLY ARG TYR SER GLY GLY LEU TYR SEQRES 39 F 522 TYR PRO THR ASN TYR ASP TYR TRP GLY GLN GLY THR GLN SEQRES 40 F 522 VAL THR VAL SER SER HIS HIS HIS HIS HIS HIS GLU PRO SEQRES 41 F 522 GLU ALA HET NAG a 1 14 HET NAG a 2 14 HET BMA a 3 11 HET MAN a 4 11 HET MAN a 5 11 HET NAG b 1 14 HET NAG b 2 14 HET BMA b 3 11 HET MAN b 4 11 HET MAN b 5 11 HET NAG G 1 14 HET NAG G 2 14 HET NAG c 1 14 HET NAG c 2 14 HET BMA c 3 11 HET MAN c 4 11 HET MAN c 5 11 HET NAG H 1 14 HET NAG H 2 14 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET MAN d 4 11 HET MAN d 5 11 HET NAG e 1 14 HET NAG e 2 14 HET BMA e 3 11 HET MAN e 4 11 HET MAN e 5 11 HET NAG I 1 14 HET NAG I 2 14 HET D10 D 501 10 HET POV D 502 52 HET CL D 503 1 HET ABU E 501 7 HET D10 E 502 10 HET ABU B 501 7 HET D10 B 502 10 HET D10 B 503 10 HET R16 B 504 16 HET D10 B 505 10 HET POV A 501 52 HET CL A 502 1 HET D10 C 501 10 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETNAM D10 DECANE HETNAM POV (2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9- HETNAM 2 POV ENOYLOXY]PROPYL 2-(TRIMETHYLAMMONIO)ETHYL PHOSPHATE HETNAM CL CHLORIDE ION HETNAM ABU GAMMA-AMINO-BUTANOIC ACID HETNAM R16 HEXADECANE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN POV POPC HETSYN ABU GAMMA(AMINO)-BUTYRIC ACID FORMUL 7 NAG 16(C8 H15 N O6) FORMUL 7 BMA 5(C6 H12 O6) FORMUL 7 MAN 10(C6 H12 O6) FORMUL 15 D10 6(C10 H22) FORMUL 16 POV 2(C42 H82 N O8 P) FORMUL 17 CL 2(CL 1-) FORMUL 18 ABU 2(C4 H9 N O2) FORMUL 23 R16 C16 H34 FORMUL 28 HOH *56(H2 O) HELIX 1 AA1 THR D 12 LEU D 23 1 12 HELIX 2 AA2 GLU D 73 LYS D 76 5 4 HELIX 3 AA3 ASN D 87 ILE D 94 5 8 HELIX 4 AA4 GLU D 174 ARG D 177 5 4 HELIX 5 AA5 ILE D 223 THR D 230 1 8 HELIX 6 AA6 THR D 230 SER D 244 1 15 HELIX 7 AA7 PHE D 245 LEU D 247 5 3 HELIX 8 AA8 SER D 251 ARG D 274 1 24 HELIX 9 AA9 THR D 284 PHE D 310 1 27 HELIX 10 AB1 GLN D 385 ARG D 418 1 34 HELIX 11 AB2 MET E 9 LEU E 20 1 12 HELIX 12 AB3 LYS E 70 ALA E 73 5 4 HELIX 13 AB4 ASP E 84 GLN E 90 5 7 HELIX 14 AB5 ASP E 139 TYR E 143 5 5 HELIX 15 AB6 GLY E 170 LYS E 173 5 4 HELIX 16 AB7 ILE E 218 THR E 225 1 8 HELIX 17 AB8 TYR E 226 TRP E 237 1 12 HELIX 18 AB9 VAL E 238 ILE E 242 5 5 HELIX 19 AC1 ALA E 246 LEU E 272 1 27 HELIX 20 AC2 LYS E 279 PHE E 306 1 28 HELIX 21 AC3 GLN E 309 TYR E 446 1 31 HELIX 22 AC4 MET B 9 LYS B 21 1 13 HELIX 23 AC5 LYS B 70 ALA B 73 5 4 HELIX 24 AC6 ASP B 84 LEU B 91 5 8 HELIX 25 AC7 GLY B 170 LYS B 173 5 4 HELIX 26 AC8 GLY B 177 ILE B 181 5 5 HELIX 27 AC9 ILE B 218 THR B 225 1 8 HELIX 28 AD1 THR B 225 SER B 236 1 12 HELIX 29 AD2 TRP B 237 ILE B 242 5 6 HELIX 30 AD3 ALA B 246 LEU B 272 1 27 HELIX 31 AD4 LYS B 279 PHE B 306 1 28 HELIX 32 AD5 GLN B 309 TYR B 446 1 31 HELIX 33 AD6 THR A 13 LEU A 23 1 11 HELIX 34 AD7 GLU A 73 LYS A 76 5 4 HELIX 35 AD8 ASN A 87 ILE A 94 5 8 HELIX 36 AD9 GLU A 174 ARG A 177 5 4 HELIX 37 AE1 ILE A 223 THR A 230 1 8 HELIX 38 AE2 THR A 230 SER A 244 1 15 HELIX 39 AE3 PHE A 245 LEU A 247 5 3 HELIX 40 AE4 SER A 251 LEU A 277 1 27 HELIX 41 AE5 THR A 284 PHE A 310 1 27 HELIX 42 AE6 GLN A 385 ASN A 417 1 33 HELIX 43 AE7 MET C 9 LYS C 21 1 13 HELIX 44 AE8 LYS C 70 ALA C 73 5 4 HELIX 45 AE9 ASP C 84 LEU C 91 5 8 HELIX 46 AF1 GLY C 170 LYS C 173 5 4 HELIX 47 AF2 ILE C 218 THR C 225 1 8 HELIX 48 AF3 TYR C 226 TRP C 237 1 12 HELIX 49 AF4 VAL C 238 ILE C 242 5 5 HELIX 50 AF5 ALA C 246 LEU C 272 1 27 HELIX 51 AF6 LYS C 279 PHE C 306 1 28 HELIX 52 AF7 GLN C 309 TYR C 446 1 31 HELIX 53 AF8 ASP F 450 LYS F 453 5 4 HELIX 54 AF9 LYS F 475 THR F 479 5 5 HELIX 55 AG1 TYR F 496 THR F 498 5 3 SHEET 1 AA1 6 VAL D 83 LEU D 86 0 SHEET 2 AA1 6 LYS D 117 THR D 122 -1 O ILE D 121 N LEU D 84 SHEET 3 AA1 6 THR D 126 GLU D 138 -1 O THR D 130 N LEU D 118 SHEET 4 AA1 6 GLU D 59 LYS D 71 -1 N ILE D 62 O VAL D 135 SHEET 5 AA1 6 THR D 39 SER D 54 -1 N SER D 54 O GLU D 59 SHEET 6 AA1 6 VAL D 167 TRP D 171 1 O VAL D 168 N VAL D 41 SHEET 1 AA2 5 VAL D 108 ALA D 109 0 SHEET 2 AA2 5 THR D 126 GLU D 138 -1 O THR D 134 N VAL D 108 SHEET 3 AA2 5 GLU D 59 LYS D 71 -1 N ILE D 62 O VAL D 135 SHEET 4 AA2 5 THR D 39 SER D 54 -1 N SER D 54 O GLU D 59 SHEET 5 AA2 5 VAL D 179 VAL D 181 1 O VAL D 180 N ILE D 45 SHEET 1 AA3 4 THR D 99 PHE D 101 0 SHEET 2 AA3 4 ALA D 150 SER D 159 -1 O GLY D 158 N PHE D 100 SHEET 3 AA3 4 GLY D 208 ARG D 221 -1 O PHE D 217 N CYS D 153 SHEET 4 AA3 4 TYR D 191 SER D 205 -1 N THR D 197 O HIS D 216 SHEET 1 AA4 6 LEU E 81 LEU E 83 0 SHEET 2 AA4 6 ARG E 114 LEU E 118 -1 O LEU E 118 N LEU E 81 SHEET 3 AA4 6 THR E 123 ALA E 135 -1 O LEU E 125 N ARG E 117 SHEET 4 AA4 6 ASP E 56 ARG E 68 -1 N LEU E 59 O THR E 132 SHEET 5 AA4 6 VAL E 36 SER E 51 -1 N SER E 51 O ASP E 56 SHEET 6 AA4 6 ILE E 164 TRP E 168 1 O GLU E 165 N VAL E 38 SHEET 1 AA5 5 ASP E 101 VAL E 106 0 SHEET 2 AA5 5 THR E 123 ALA E 135 -1 O THR E 133 N LYS E 102 SHEET 3 AA5 5 ASP E 56 ARG E 68 -1 N LEU E 59 O THR E 132 SHEET 4 AA5 5 VAL E 36 SER E 51 -1 N SER E 51 O ASP E 56 SHEET 5 AA5 5 VAL E 175 THR E 176 1 O THR E 176 N ILE E 44 SHEET 1 AA6 4 THR E 96 PHE E 98 0 SHEET 2 AA6 4 GLU E 147 SER E 156 -1 O GLU E 155 N TYR E 97 SHEET 3 AA6 4 GLY E 203 ARG E 216 -1 O LEU E 208 N ILE E 154 SHEET 4 AA6 4 PHE E 186 PHE E 200 -1 N PHE E 200 O GLY E 203 SHEET 1 AA7 6 THR B 82 LEU B 83 0 SHEET 2 AA7 6 ARG B 114 LEU B 118 -1 O ILE B 116 N LEU B 83 SHEET 3 AA7 6 THR B 123 ALA B 135 -1 O LEU B 125 N ARG B 117 SHEET 4 AA7 6 ASP B 56 ARG B 68 -1 N TYR B 57 O ALA B 134 SHEET 5 AA7 6 VAL B 36 SER B 51 -1 N SER B 51 O ASP B 56 SHEET 6 AA7 6 ILE B 164 TRP B 168 1 O GLU B 165 N VAL B 38 SHEET 1 AA8 5 ASP B 101 VAL B 106 0 SHEET 2 AA8 5 THR B 123 ALA B 135 -1 O THR B 133 N LYS B 102 SHEET 3 AA8 5 ASP B 56 ARG B 68 -1 N TYR B 57 O ALA B 134 SHEET 4 AA8 5 VAL B 36 SER B 51 -1 N SER B 51 O ASP B 56 SHEET 5 AA8 5 VAL B 175 THR B 176 1 O THR B 176 N ILE B 42 SHEET 1 AA9 4 THR B 96 PHE B 98 0 SHEET 2 AA9 4 GLU B 147 SER B 156 -1 O GLU B 155 N TYR B 97 SHEET 3 AA9 4 GLY B 203 LYS B 215 -1 O LEU B 208 N ILE B 154 SHEET 4 AA9 4 ILE B 188 PHE B 200 -1 N VAL B 189 O ARG B 213 SHEET 1 AB1 6 VAL A 83 LEU A 86 0 SHEET 2 AB1 6 LYS A 117 THR A 122 -1 O ILE A 121 N LEU A 84 SHEET 3 AB1 6 THR A 126 GLU A 138 -1 O THR A 126 N THR A 122 SHEET 4 AB1 6 GLU A 59 LYS A 71 -1 N GLN A 68 O TYR A 129 SHEET 5 AB1 6 THR A 39 SER A 54 -1 N ASP A 44 O ARG A 67 SHEET 6 AB1 6 VAL A 167 TRP A 171 1 O GLU A 170 N THR A 43 SHEET 1 AB2 5 VAL A 108 ALA A 109 0 SHEET 2 AB2 5 THR A 126 GLU A 138 -1 O THR A 134 N VAL A 108 SHEET 3 AB2 5 GLU A 59 LYS A 71 -1 N GLN A 68 O TYR A 129 SHEET 4 AB2 5 THR A 39 SER A 54 -1 N ASP A 44 O ARG A 67 SHEET 5 AB2 5 VAL A 179 VAL A 181 1 O VAL A 180 N ILE A 45 SHEET 1 AB3 4 THR A 99 PHE A 101 0 SHEET 2 AB3 4 ALA A 150 SER A 159 -1 O GLY A 158 N PHE A 100 SHEET 3 AB3 4 GLY A 208 ARG A 221 -1 O MET A 213 N PHE A 157 SHEET 4 AB3 4 TYR A 191 SER A 205 -1 N SER A 205 O GLY A 208 SHEET 1 AB4 6 LEU C 81 LEU C 83 0 SHEET 2 AB4 6 ARG C 114 LEU C 118 -1 O LEU C 118 N LEU C 81 SHEET 3 AB4 6 THR C 123 ALA C 135 -1 O LEU C 125 N ARG C 117 SHEET 4 AB4 6 ASP C 56 ARG C 68 -1 N TYR C 57 O ALA C 134 SHEET 5 AB4 6 VAL C 36 ILE C 47 -1 N ALA C 45 O THR C 60 SHEET 6 AB4 6 ILE C 164 TRP C 168 1 O GLU C 165 N VAL C 38 SHEET 1 AB5 5 ASP C 101 VAL C 106 0 SHEET 2 AB5 5 THR C 123 ALA C 135 -1 O THR C 133 N LYS C 102 SHEET 3 AB5 5 ASP C 56 ARG C 68 -1 N TYR C 57 O ALA C 134 SHEET 4 AB5 5 VAL C 36 ILE C 47 -1 N ALA C 45 O THR C 60 SHEET 5 AB5 5 VAL C 175 THR C 176 1 O THR C 176 N ILE C 44 SHEET 1 AB6 4 THR C 96 PHE C 98 0 SHEET 2 AB6 4 GLU C 147 SER C 156 -1 O GLU C 155 N TYR C 97 SHEET 3 AB6 4 GLY C 203 ARG C 216 -1 O LEU C 208 N ILE C 154 SHEET 4 AB6 4 PHE C 186 PHE C 200 -1 N VAL C 189 O ARG C 213 SHEET 1 AB7 4 VAL F 3 SER F 8 0 SHEET 2 AB7 4 ARG F 407 GLY F 414 -1 O SER F 413 N GLN F 4 SHEET 3 AB7 4 THR F 466 MET F 471 -1 O VAL F 467 N CYS F 410 SHEET 4 AB7 4 PHE F 456 ASP F 461 -1 N ASP F 461 O THR F 466 SHEET 1 AB8 5 THR F 446 TYR F 448 0 SHEET 2 AB8 5 ARG F 433 SER F 440 -1 N ALA F 438 O SER F 447 SHEET 3 AB8 5 ILE F 421 GLN F 427 -1 N TRP F 424 O GLY F 437 SHEET 4 AB8 5 ALA F 480 LYS F 487 -1 O ALA F 485 N GLY F 423 SHEET 5 AB8 5 TYR F 500 TRP F 503 -1 O TYR F 502 N ALA F 486 SHEET 1 AB9 5 THR F 446 TYR F 448 0 SHEET 2 AB9 5 ARG F 433 SER F 440 -1 N ALA F 438 O SER F 447 SHEET 3 AB9 5 ILE F 421 GLN F 427 -1 N TRP F 424 O GLY F 437 SHEET 4 AB9 5 ALA F 480 LYS F 487 -1 O ALA F 485 N GLY F 423 SHEET 5 AB9 5 GLN F 508 VAL F 509 -1 O VAL F 509 N ALA F 480 SSBOND 1 CYS D 139 CYS D 153 1555 1555 2.04 SSBOND 2 CYS E 136 CYS E 150 1555 1555 2.04 SSBOND 3 CYS B 136 CYS B 150 1555 1555 2.04 SSBOND 4 CYS A 139 CYS A 153 1555 1555 2.04 SSBOND 5 CYS C 136 CYS C 150 1555 1555 2.03 SSBOND 6 CYS F 410 CYS F 484 1555 1555 2.04 LINK ND2 ASN D 111 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN E 80 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN E 149 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN B 80 C1 NAG H 1 1555 1555 1.44 LINK ND2 ASN B 149 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN A 111 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN C 80 C1 NAG I 1 1555 1555 1.44 LINK ND2 ASN C 149 C1 NAG e 1 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.44 LINK O4 NAG a 2 C1 BMA a 3 1555 1555 1.44 LINK O3 BMA a 3 C1 MAN a 4 1555 1555 1.44 LINK O6 BMA a 3 C1 MAN a 5 1555 1555 1.44 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.44 LINK O4 NAG b 2 C1 BMA b 3 1555 1555 1.44 LINK O3 BMA b 3 C1 MAN b 4 1555 1555 1.44 LINK O6 BMA b 3 C1 MAN b 5 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.45 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.43 LINK O4 NAG c 2 C1 BMA c 3 1555 1555 1.44 LINK O3 BMA c 3 C1 MAN c 4 1555 1555 1.44 LINK O6 BMA c 3 C1 MAN c 5 1555 1555 1.44 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.43 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.44 LINK O3 BMA d 3 C1 MAN d 4 1555 1555 1.44 LINK O6 BMA d 3 C1 MAN d 5 1555 1555 1.44 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.43 LINK O4 NAG e 2 C1 BMA e 3 1555 1555 1.44 LINK O3 BMA e 3 C1 MAN e 4 1555 1555 1.44 LINK O6 BMA e 3 C1 MAN e 5 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.44 CISPEP 1 MET D 112 THR D 113 0 -0.23 CISPEP 2 PHE D 146 PRO D 147 0 1.02 CISPEP 3 VAL E 109 THR E 110 0 4.46 CISPEP 4 TYR E 143 PRO E 144 0 5.20 CISPEP 5 VAL B 109 THR B 110 0 2.68 CISPEP 6 TYR B 143 PRO B 144 0 4.36 CISPEP 7 MET A 112 THR A 113 0 0.07 CISPEP 8 PHE A 146 PRO A 147 0 -0.52 CISPEP 9 VAL C 109 THR C 110 0 4.52 CISPEP 10 TYR C 143 PRO C 144 0 -0.84 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000