HEADER IMMUNE SYSTEM 24-SEP-24 9JO9 TITLE CRP-HCAB3 COMPLEX COMPND MOL_ID: 1; COMPND 2 MOLECULE: CRP SPECIFIC RECOGNITION HEAVY CHAIN ANTIBODIE 3 (HCAB3); COMPND 3 CHAIN: O, A, C, E, G, I, K, M, P, R; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: C-REACTIVE PROTEIN; COMPND 7 CHAIN: S, B, D, F, H, J, L, N, Q, T; COMPND 8 SYNONYM: C-REACTIVE PROTEIN PENTAMER; COMPND 9 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: VICUGNA PACOS; SOURCE 3 ORGANISM_TAXID: 30538; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_COMMON: HUMAN; SOURCE 10 ORGANISM_TAXID: 9606; SOURCE 11 GENE: CRP, PTX1; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS C REACTIVE PROTEIN AND ANTIBODY COMPLEX, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR Y.J.LI REVDAT 1 22-OCT-25 9JO9 0 JRNL AUTH Y.J.LI JRNL TITL CRP-HCAB3 COMPLEX JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.65 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.650 REMARK 3 NUMBER OF PARTICLES : 249262 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9JO9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 29-SEP-24. REMARK 100 THE DEPOSITION ID IS D_1300051443. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : C5 SYMMETRY PENTAMER COMPLEX OF REMARK 245 CRP ANTIGEN AND ANTIBODY4 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 3000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: EICOSAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: O, S, A, B, C, D, E, F, G, H, REMARK 350 AND CHAINS: I, J, K, L, M, N, P, Q, R, T REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET O 1 REMARK 465 ALA O 2 REMARK 465 SER O 128 REMARK 465 MET A 1 REMARK 465 ALA A 2 REMARK 465 SER A 128 REMARK 465 MET C 1 REMARK 465 ALA C 2 REMARK 465 SER C 128 REMARK 465 MET E 1 REMARK 465 ALA E 2 REMARK 465 SER E 128 REMARK 465 MET G 1 REMARK 465 ALA G 2 REMARK 465 SER G 128 REMARK 465 MET I 1 REMARK 465 ALA I 2 REMARK 465 SER I 128 REMARK 465 MET K 1 REMARK 465 ALA K 2 REMARK 465 SER K 128 REMARK 465 MET M 1 REMARK 465 ALA M 2 REMARK 465 SER M 128 REMARK 465 MET P 1 REMARK 465 ALA P 2 REMARK 465 SER P 128 REMARK 465 MET R 1 REMARK 465 ALA R 2 REMARK 465 SER R 128 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ARG O 21 76.61 -101.40 REMARK 500 ASN O 32 0.40 -66.50 REMARK 500 VAL O 50 -58.65 -121.62 REMARK 500 ASN O 79 59.52 38.52 REMARK 500 ALA O 94 -168.73 -170.68 REMARK 500 SER O 101 -163.40 -161.00 REMARK 500 GLN O 102 66.66 61.28 REMARK 500 THR S 27 -32.85 -132.02 REMARK 500 ASP S 70 -1.81 72.52 REMARK 500 ARG A 21 76.78 -101.89 REMARK 500 VAL A 50 -57.87 -121.42 REMARK 500 ALA A 51 -169.50 -160.52 REMARK 500 ALA A 94 -169.30 -167.32 REMARK 500 SER A 101 79.94 -161.79 REMARK 500 SER A 103 -18.07 -49.68 REMARK 500 SER A 104 -156.31 -100.47 REMARK 500 THR B 27 -54.05 -123.62 REMARK 500 SER B 45 46.80 -86.66 REMARK 500 GLN B 59 112.68 -167.16 REMARK 500 ASP B 70 -7.21 73.63 REMARK 500 ARG C 21 77.21 -101.15 REMARK 500 VAL C 50 -58.27 -121.49 REMARK 500 ASN C 79 57.76 34.50 REMARK 500 ASN C 87 60.25 38.43 REMARK 500 ALA C 94 -169.82 -167.59 REMARK 500 SER C 101 108.59 -164.45 REMARK 500 GLN C 102 119.92 -174.64 REMARK 500 TYR C 106 -176.69 -173.91 REMARK 500 ILE D 71 -56.79 -124.63 REMARK 500 LEU D 121 112.93 -164.46 REMARK 500 ASN D 145 62.63 63.65 REMARK 500 VAL E 50 -58.79 -121.31 REMARK 500 ASN E 79 58.23 34.43 REMARK 500 SER E 101 -65.79 -135.19 REMARK 500 GLN E 102 105.97 -59.91 REMARK 500 SER E 104 -168.37 -121.53 REMARK 500 THR F 27 -32.97 -131.99 REMARK 500 ASP F 70 -1.72 72.36 REMARK 500 ARG G 21 77.11 -100.76 REMARK 500 ASN G 32 3.72 -69.39 REMARK 500 VAL G 50 -57.94 -121.13 REMARK 500 ASN G 79 58.18 33.81 REMARK 500 ALA G 94 -168.59 -166.82 REMARK 500 SER G 101 110.07 -164.07 REMARK 500 SER G 104 -156.07 -116.42 REMARK 500 THR H 27 -33.01 -131.95 REMARK 500 ASP H 70 -1.65 72.12 REMARK 500 ASN H 145 43.48 70.31 REMARK 500 LYS I 45 -179.31 -172.16 REMARK 500 VAL I 50 -58.32 -120.73 REMARK 500 REMARK 500 THIS ENTRY HAS 97 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-61648 RELATED DB: EMDB REMARK 900 CRP-HCAB3 COMPLEX DBREF 9JO9 O 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 S 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 A 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 B 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 C 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 D 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 E 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 F 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 G 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 H 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 I 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 J 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 K 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 L 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 M 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 N 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 P 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 Q 1 206 UNP P02741 CRP_HUMAN 19 224 DBREF 9JO9 R 1 128 PDB 9JO9 9JO9 1 128 DBREF 9JO9 T 1 206 UNP P02741 CRP_HUMAN 19 224 SEQRES 1 O 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 O 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 O 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 O 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 O 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 O 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 O 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 O 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 O 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 O 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 S 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 S 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 S 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 S 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 S 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 S 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 S 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 S 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 S 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 S 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 S 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 S 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 S 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 S 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 S 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 S 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 A 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 A 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 A 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 A 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 A 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 A 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 A 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 A 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 A 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 A 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 B 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 B 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 B 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 B 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 B 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 B 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 B 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 B 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 B 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 B 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 B 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 B 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 B 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 B 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 B 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 B 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 C 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 C 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 C 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 C 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 C 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 C 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 C 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 C 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 C 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 C 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 D 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 D 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 D 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 D 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 D 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 D 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 D 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 D 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 D 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 D 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 D 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 D 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 D 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 D 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 D 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 D 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 E 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 E 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 E 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 E 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 E 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 E 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 E 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 E 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 E 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 E 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 F 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 F 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 F 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 F 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 F 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 F 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 F 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 F 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 F 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 F 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 F 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 F 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 F 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 F 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 F 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 F 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 G 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 G 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 G 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 G 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 G 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 G 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 G 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 G 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 G 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 G 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 H 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 H 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 H 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 H 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 H 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 H 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 H 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 H 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 H 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 H 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 H 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 H 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 H 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 H 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 H 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 H 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 I 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 I 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 I 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 I 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 I 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 I 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 I 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 I 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 I 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 I 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 J 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 J 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 J 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 J 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 J 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 J 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 J 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 J 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 J 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 J 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 J 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 J 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 J 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 J 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 J 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 J 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 K 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 K 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 K 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 K 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 K 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 K 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 K 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 K 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 K 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 K 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 L 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 L 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 L 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 L 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 L 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 L 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 L 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 L 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 L 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 L 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 L 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 L 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 L 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 L 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 L 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 L 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 M 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 M 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 M 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 M 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 M 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 M 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 M 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 M 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 M 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 M 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 N 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 N 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 N 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 N 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 N 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 N 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 N 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 N 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 N 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 N 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 N 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 N 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 N 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 N 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 N 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 N 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 P 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 P 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 P 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 P 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 P 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 P 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 P 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 P 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 P 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 P 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 Q 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 Q 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 Q 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 Q 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 Q 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 Q 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 Q 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 Q 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 Q 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 Q 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 Q 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 Q 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 Q 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 Q 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 Q 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 Q 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO SEQRES 1 R 128 MET ALA GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU SEQRES 2 R 128 VAL GLN THR GLY GLY SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 R 128 SER GLY ARG THR PHE ASN ARG HIS TYR MET GLY TRP PHE SEQRES 4 R 128 ARG GLN VAL PRO GLY LYS GLU ARG GLU PHE VAL ALA SER SEQRES 5 R 128 ILE SER GLN THR GLY LEU ASN LYS ASP TYR VAL ASP SER SEQRES 6 R 128 ALA LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLU SEQRES 7 R 128 ASN THR VAL TYR LEU GLN MET ASN ASN LEU LYS PRO GLU SEQRES 8 R 128 ASP THR ALA LEU TYR TYR CYS ALA GLY SER GLN SER SER SEQRES 9 R 128 TYR TYR ASP LYS PRO ARG LEU LEU THR GLU TYR ALA TYR SEQRES 10 R 128 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER SEQRES 1 T 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS SEQRES 2 T 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU SEQRES 3 T 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE SEQRES 4 T 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE SEQRES 5 T 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE SEQRES 6 T 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY SEQRES 7 T 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL SEQRES 8 T 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER SEQRES 9 T 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL SEQRES 10 T 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU SEQRES 11 T 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY SEQRES 12 T 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE SEQRES 13 T 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP SEQRES 14 T 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO SEQRES 15 T 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN SEQRES 16 T 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO HELIX 1 AA1 THR O 30 HIS O 34 5 5 HELIX 2 AA2 LEU S 43 THR S 46 5 4 HELIX 3 AA3 SER S 167 GLY S 177 1 11 HELIX 4 AA4 THR A 30 HIS A 34 5 5 HELIX 5 AA5 GLU B 42 THR B 46 5 5 HELIX 6 AA6 SER B 167 LEU B 176 1 10 HELIX 7 AA7 ASN B 186 LEU B 190 5 5 HELIX 8 AA8 THR C 30 HIS C 34 5 5 HELIX 9 AA9 GLU D 42 THR D 46 5 5 HELIX 10 AB1 GLU D 147 SER D 151 5 5 HELIX 11 AB2 SER D 167 GLY D 177 1 11 HELIX 12 AB3 ASN D 186 LEU D 190 5 5 HELIX 13 AB4 THR E 30 HIS E 34 5 5 HELIX 14 AB5 GLU F 42 THR F 46 5 5 HELIX 15 AB6 SER F 167 GLY F 177 1 11 HELIX 16 AB7 THR G 30 HIS G 34 5 5 HELIX 17 AB8 SER H 167 GLY H 177 1 11 HELIX 18 AB9 THR I 30 HIS I 34 5 5 HELIX 19 AC1 LEU J 43 THR J 46 5 4 HELIX 20 AC2 SER J 167 GLY J 177 1 11 HELIX 21 AC3 THR K 30 HIS K 34 5 5 HELIX 22 AC4 LEU L 43 THR L 46 5 4 HELIX 23 AC5 SER L 167 GLY L 177 1 11 HELIX 24 AC6 THR M 30 HIS M 34 5 5 HELIX 25 AC7 GLU N 42 THR N 46 5 5 HELIX 26 AC8 SER N 167 GLY N 177 1 11 HELIX 27 AC9 ASN N 186 LEU N 190 5 5 HELIX 28 AD1 THR P 30 HIS P 34 5 5 HELIX 29 AD2 SER Q 167 GLY Q 177 1 11 HELIX 30 AD3 ASN Q 186 LEU Q 190 5 5 HELIX 31 AD4 THR R 30 HIS R 34 5 5 HELIX 32 AD5 GLU T 42 THR T 46 5 5 HELIX 33 AD6 SER T 167 GLY T 177 1 11 HELIX 34 AD7 ASN T 186 LEU T 190 5 5 SHEET 1 AA1 4 GLN O 5 SER O 9 0 SHEET 2 AA1 4 SER O 19 SER O 27 -1 O SER O 23 N SER O 9 SHEET 3 AA1 4 THR O 80 ASN O 86 -1 O LEU O 83 N LEU O 22 SHEET 4 AA1 4 PHE O 70 ASP O 75 -1 N SER O 73 O TYR O 82 SHEET 1 AA2 6 GLY O 12 GLN O 15 0 SHEET 2 AA2 6 THR O 122 SER O 127 1 O THR O 125 N GLY O 12 SHEET 3 AA2 6 ALA O 94 SER O 101 -1 N TYR O 96 O THR O 122 SHEET 4 AA2 6 TYR O 35 GLN O 41 -1 N GLN O 41 O LEU O 95 SHEET 5 AA2 6 GLU O 48 ILE O 53 -1 O GLU O 48 N ARG O 40 SHEET 6 AA2 6 LYS O 60 TYR O 62 -1 O ASP O 61 N SER O 52 SHEET 1 AA3 3 LYS S 114 PRO S 115 0 SHEET 2 AA3 3 ILE S 106 VAL S 111 -1 N VAL S 111 O LYS S 114 SHEET 3 AA3 3 LYS S 119 SER S 120 -1 O LYS S 119 N VAL S 107 SHEET 1 AA4 7 LYS S 114 PRO S 115 0 SHEET 2 AA4 7 ILE S 106 VAL S 111 -1 N VAL S 111 O LYS S 114 SHEET 3 AA4 7 VAL S 94 GLU S 101 -1 N CYS S 97 O TRP S 110 SHEET 4 AA4 7 ALA S 32 THR S 41 -1 N PHE S 39 O VAL S 94 SHEET 5 AA4 7 GLY S 154 MET S 161 -1 O ASN S 160 N CYS S 36 SHEET 6 AA4 7 LYS S 7 PHE S 11 -1 N PHE S 11 O GLY S 154 SHEET 7 AA4 7 PHE S 199 PRO S 202 -1 O LYS S 201 N ALA S 8 SHEET 1 AA5 7 SER S 80 GLU S 85 0 SHEET 2 AA5 7 GLY S 72 VAL S 77 -1 N TYR S 73 O PHE S 84 SHEET 3 AA5 7 GLN S 59 SER S 68 -1 N PHE S 66 O SER S 74 SHEET 4 AA5 7 TYR S 49 THR S 56 -1 N TYR S 54 O ILE S 63 SHEET 5 AA5 7 SER S 132 LEU S 135 -1 O ILE S 134 N SER S 53 SHEET 6 AA5 7 TYR S 19 LEU S 22 -1 N VAL S 20 O LEU S 135 SHEET 7 AA5 7 TYR S 192 GLN S 195 -1 O GLU S 193 N SER S 21 SHEET 1 AA6 4 GLN A 5 SER A 9 0 SHEET 2 AA6 4 SER A 19 SER A 27 -1 O SER A 23 N SER A 9 SHEET 3 AA6 4 THR A 80 ASN A 86 -1 O LEU A 83 N LEU A 22 SHEET 4 AA6 4 PHE A 70 ASP A 75 -1 N ASP A 75 O THR A 80 SHEET 1 AA7 6 GLY A 12 GLN A 15 0 SHEET 2 AA7 6 THR A 122 SER A 127 1 O THR A 125 N GLY A 12 SHEET 3 AA7 6 ALA A 94 ALA A 99 -1 N TYR A 96 O THR A 122 SHEET 4 AA7 6 MET A 36 GLN A 41 -1 N GLN A 41 O LEU A 95 SHEET 5 AA7 6 ARG A 47 ILE A 53 -1 O GLU A 48 N ARG A 40 SHEET 6 AA7 6 LYS A 60 TYR A 62 -1 O ASP A 61 N SER A 52 SHEET 1 AA8 7 LYS B 114 SER B 120 0 SHEET 2 AA8 7 ILE B 106 VAL B 111 -1 N VAL B 111 O LYS B 114 SHEET 3 AA8 7 VAL B 94 GLU B 101 -1 N CYS B 97 O TRP B 110 SHEET 4 AA8 7 ALA B 32 TYR B 40 -1 N VAL B 35 O THR B 98 SHEET 5 AA8 7 GLY B 154 MET B 161 -1 O ASN B 160 N CYS B 36 SHEET 6 AA8 7 LYS B 7 PHE B 11 -1 N PHE B 11 O GLY B 154 SHEET 7 AA8 7 PHE B 199 PRO B 202 -1 O LYS B 201 N ALA B 8 SHEET 1 AA9 7 SER B 80 GLU B 85 0 SHEET 2 AA9 7 GLY B 72 VAL B 77 -1 N TYR B 73 O PHE B 84 SHEET 3 AA9 7 GLN B 59 SER B 68 -1 N PHE B 66 O SER B 74 SHEET 4 AA9 7 TYR B 49 THR B 56 -1 N TYR B 54 O ILE B 63 SHEET 5 AA9 7 SER B 132 LEU B 135 -1 O SER B 132 N ALA B 55 SHEET 6 AA9 7 TYR B 19 LEU B 22 -1 N LEU B 22 O ILE B 133 SHEET 7 AA9 7 TYR B 192 GLN B 195 -1 O GLU B 193 N SER B 21 SHEET 1 AB1 4 GLN C 5 SER C 9 0 SHEET 2 AB1 4 LEU C 20 SER C 27 -1 O SER C 23 N SER C 9 SHEET 3 AB1 4 THR C 80 MET C 85 -1 O MET C 85 N LEU C 20 SHEET 4 AB1 4 THR C 71 ASP C 75 -1 N SER C 73 O TYR C 82 SHEET 1 AB2 6 GLY C 12 GLN C 15 0 SHEET 2 AB2 6 THR C 122 SER C 127 1 O THR C 125 N GLY C 12 SHEET 3 AB2 6 ALA C 94 GLY C 100 -1 N TYR C 96 O THR C 122 SHEET 4 AB2 6 MET C 36 GLN C 41 -1 N GLN C 41 O LEU C 95 SHEET 5 AB2 6 GLU C 48 ILE C 53 -1 O GLU C 48 N ARG C 40 SHEET 6 AB2 6 LYS C 60 TYR C 62 -1 O ASP C 61 N SER C 52 SHEET 1 AB3 7 LYS D 114 SER D 120 0 SHEET 2 AB3 7 ILE D 106 VAL D 111 -1 N VAL D 111 O LYS D 114 SHEET 3 AB3 7 VAL D 94 GLU D 101 -1 N CYS D 97 O TRP D 110 SHEET 4 AB3 7 ALA D 32 TYR D 40 -1 N VAL D 35 O THR D 98 SHEET 5 AB3 7 GLY D 154 TRP D 162 -1 O GLY D 157 N HIS D 38 SHEET 6 AB3 7 LYS D 7 PHE D 11 -1 N PHE D 11 O GLY D 154 SHEET 7 AB3 7 PHE D 199 PRO D 202 -1 O LYS D 201 N ALA D 8 SHEET 1 AB4 7 GLU D 81 GLU D 85 0 SHEET 2 AB4 7 GLY D 72 VAL D 77 -1 N PHE D 75 O ILE D 82 SHEET 3 AB4 7 GLN D 59 SER D 68 -1 N PHE D 66 O SER D 74 SHEET 4 AB4 7 TYR D 49 THR D 56 -1 N THR D 56 O GLN D 59 SHEET 5 AB4 7 SER D 132 LEU D 135 -1 O ILE D 134 N SER D 53 SHEET 6 AB4 7 TYR D 19 LEU D 22 -1 N LEU D 22 O ILE D 133 SHEET 7 AB4 7 TYR D 192 GLN D 195 -1 O GLU D 193 N SER D 21 SHEET 1 AB5 4 GLN E 5 SER E 9 0 SHEET 2 AB5 4 SER E 19 SER E 27 -1 O SER E 23 N SER E 9 SHEET 3 AB5 4 THR E 80 ASN E 86 -1 O LEU E 83 N LEU E 22 SHEET 4 AB5 4 PHE E 70 ASP E 75 -1 N SER E 73 O TYR E 82 SHEET 1 AB6 6 GLY E 12 GLN E 15 0 SHEET 2 AB6 6 THR E 122 SER E 127 1 O THR E 125 N GLY E 12 SHEET 3 AB6 6 ALA E 94 GLY E 100 -1 N TYR E 96 O THR E 122 SHEET 4 AB6 6 MET E 36 GLN E 41 -1 N GLN E 41 O LEU E 95 SHEET 5 AB6 6 ARG E 47 ILE E 53 -1 O GLU E 48 N ARG E 40 SHEET 6 AB6 6 LYS E 60 TYR E 62 -1 O ASP E 61 N SER E 52 SHEET 1 AB7 4 GLY E 12 GLN E 15 0 SHEET 2 AB7 4 THR E 122 SER E 127 1 O THR E 125 N GLY E 12 SHEET 3 AB7 4 ALA E 94 GLY E 100 -1 N TYR E 96 O THR E 122 SHEET 4 AB7 4 TYR E 117 TRP E 118 -1 O TYR E 117 N GLY E 100 SHEET 1 AB8 3 LYS F 114 PRO F 115 0 SHEET 2 AB8 3 ILE F 106 VAL F 111 -1 N VAL F 111 O LYS F 114 SHEET 3 AB8 3 LYS F 119 SER F 120 -1 O LYS F 119 N VAL F 107 SHEET 1 AB9 7 LYS F 114 PRO F 115 0 SHEET 2 AB9 7 ILE F 106 VAL F 111 -1 N VAL F 111 O LYS F 114 SHEET 3 AB9 7 VAL F 94 GLU F 101 -1 N CYS F 97 O TRP F 110 SHEET 4 AB9 7 ALA F 32 TYR F 40 -1 N PHE F 39 O VAL F 94 SHEET 5 AB9 7 GLY F 154 MET F 161 -1 O ASN F 160 N CYS F 36 SHEET 6 AB9 7 LYS F 7 PHE F 11 -1 N PHE F 9 O ILE F 156 SHEET 7 AB9 7 PHE F 199 PRO F 202 -1 O LYS F 201 N ALA F 8 SHEET 1 AC1 7 SER F 80 GLU F 85 0 SHEET 2 AC1 7 GLY F 72 VAL F 77 -1 N TYR F 73 O PHE F 84 SHEET 3 AC1 7 GLN F 59 SER F 68 -1 N PHE F 66 O SER F 74 SHEET 4 AC1 7 TYR F 49 THR F 56 -1 N TYR F 54 O ILE F 63 SHEET 5 AC1 7 SER F 132 LEU F 135 -1 O ILE F 134 N SER F 53 SHEET 6 AC1 7 TYR F 19 LEU F 22 -1 N VAL F 20 O LEU F 135 SHEET 7 AC1 7 TYR F 192 GLN F 195 -1 O GLU F 193 N SER F 21 SHEET 1 AC2 4 GLN G 5 SER G 9 0 SHEET 2 AC2 4 SER G 19 SER G 27 -1 O SER G 23 N SER G 9 SHEET 3 AC2 4 THR G 80 ASN G 86 -1 O MET G 85 N LEU G 20 SHEET 4 AC2 4 PHE G 70 ASP G 75 -1 N SER G 73 O TYR G 82 SHEET 1 AC3 6 GLY G 12 GLN G 15 0 SHEET 2 AC3 6 THR G 122 SER G 127 1 O THR G 125 N GLY G 12 SHEET 3 AC3 6 LEU G 95 ALA G 99 -1 N TYR G 96 O THR G 122 SHEET 4 AC3 6 MET G 36 GLN G 41 -1 N GLN G 41 O LEU G 95 SHEET 5 AC3 6 ARG G 47 ILE G 53 -1 O GLU G 48 N ARG G 40 SHEET 6 AC3 6 LYS G 60 TYR G 62 -1 O ASP G 61 N SER G 52 SHEET 1 AC4 3 LYS H 114 PRO H 115 0 SHEET 2 AC4 3 ILE H 106 VAL H 111 -1 N VAL H 111 O LYS H 114 SHEET 3 AC4 3 LYS H 119 SER H 120 -1 O LYS H 119 N VAL H 107 SHEET 1 AC5 7 LYS H 114 PRO H 115 0 SHEET 2 AC5 7 ILE H 106 VAL H 111 -1 N VAL H 111 O LYS H 114 SHEET 3 AC5 7 VAL H 94 GLU H 101 -1 N CYS H 97 O TRP H 110 SHEET 4 AC5 7 ALA H 32 THR H 41 -1 N PHE H 39 O VAL H 94 SHEET 5 AC5 7 GLY H 154 MET H 161 -1 O ASN H 160 N CYS H 36 SHEET 6 AC5 7 LYS H 7 PHE H 11 -1 N PHE H 9 O ILE H 156 SHEET 7 AC5 7 PHE H 199 PRO H 202 -1 O LYS H 201 N ALA H 8 SHEET 1 AC6 7 SER H 80 GLU H 85 0 SHEET 2 AC6 7 GLY H 72 VAL H 77 -1 N TYR H 73 O PHE H 84 SHEET 3 AC6 7 GLN H 59 SER H 68 -1 N PHE H 66 O SER H 74 SHEET 4 AC6 7 TYR H 49 THR H 56 -1 N TYR H 54 O ILE H 63 SHEET 5 AC6 7 SER H 132 LEU H 135 -1 O ILE H 134 N SER H 53 SHEET 6 AC6 7 TYR H 19 LEU H 22 -1 N VAL H 20 O LEU H 135 SHEET 7 AC6 7 TYR H 192 GLN H 195 -1 O GLU H 193 N SER H 21 SHEET 1 AC7 4 GLN I 5 SER I 9 0 SHEET 2 AC7 4 SER I 19 SER I 27 -1 O ALA I 25 N VAL I 7 SHEET 3 AC7 4 THR I 80 ASN I 86 -1 O MET I 85 N LEU I 20 SHEET 4 AC7 4 PHE I 70 ASP I 75 -1 N SER I 73 O TYR I 82 SHEET 1 AC8 6 GLY I 12 GLN I 15 0 SHEET 2 AC8 6 THR I 122 SER I 127 1 O THR I 125 N GLY I 12 SHEET 3 AC8 6 ALA I 94 SER I 101 -1 N TYR I 96 O THR I 122 SHEET 4 AC8 6 TYR I 35 GLN I 41 -1 N GLN I 41 O LEU I 95 SHEET 5 AC8 6 ARG I 47 ILE I 53 -1 O GLU I 48 N ARG I 40 SHEET 6 AC8 6 LYS I 60 TYR I 62 -1 O ASP I 61 N SER I 52 SHEET 1 AC9 3 LYS J 114 PRO J 115 0 SHEET 2 AC9 3 ILE J 106 VAL J 111 -1 N VAL J 111 O LYS J 114 SHEET 3 AC9 3 LYS J 119 SER J 120 -1 O LYS J 119 N VAL J 107 SHEET 1 AD1 7 LYS J 114 PRO J 115 0 SHEET 2 AD1 7 ILE J 106 VAL J 111 -1 N VAL J 111 O LYS J 114 SHEET 3 AD1 7 VAL J 94 GLU J 101 -1 N CYS J 97 O TRP J 110 SHEET 4 AD1 7 ALA J 32 THR J 41 -1 N PHE J 39 O VAL J 94 SHEET 5 AD1 7 GLY J 154 MET J 161 -1 O ASP J 155 N TYR J 40 SHEET 6 AD1 7 LYS J 7 PHE J 11 -1 N PHE J 11 O GLY J 154 SHEET 7 AD1 7 PHE J 199 PRO J 202 -1 O LYS J 201 N ALA J 8 SHEET 1 AD2 7 SER J 80 GLU J 85 0 SHEET 2 AD2 7 GLY J 72 VAL J 77 -1 N TYR J 73 O PHE J 84 SHEET 3 AD2 7 GLN J 59 SER J 68 -1 N PHE J 66 O SER J 74 SHEET 4 AD2 7 TYR J 49 THR J 56 -1 N TYR J 54 O ILE J 63 SHEET 5 AD2 7 SER J 132 LEU J 135 -1 O SER J 132 N ALA J 55 SHEET 6 AD2 7 TYR J 19 LEU J 22 -1 N LEU J 22 O ILE J 133 SHEET 7 AD2 7 TYR J 192 GLN J 195 -1 O GLN J 195 N TYR J 19 SHEET 1 AD3 4 GLN K 5 SER K 9 0 SHEET 2 AD3 4 SER K 19 SER K 27 -1 O ALA K 25 N VAL K 7 SHEET 3 AD3 4 THR K 80 ASN K 86 -1 O VAL K 81 N CYS K 24 SHEET 4 AD3 4 PHE K 70 ASP K 75 -1 N SER K 73 O TYR K 82 SHEET 1 AD4 6 GLY K 12 VAL K 14 0 SHEET 2 AD4 6 THR K 122 VAL K 126 1 O THR K 125 N GLY K 12 SHEET 3 AD4 6 ALA K 94 ALA K 99 -1 N TYR K 96 O THR K 122 SHEET 4 AD4 6 MET K 36 GLN K 41 -1 N PHE K 39 O TYR K 97 SHEET 5 AD4 6 ARG K 47 ILE K 53 -1 O GLU K 48 N ARG K 40 SHEET 6 AD4 6 LYS K 60 TYR K 62 -1 O ASP K 61 N SER K 52 SHEET 1 AD5 3 LYS L 114 PRO L 115 0 SHEET 2 AD5 3 ILE L 106 VAL L 111 -1 N VAL L 111 O LYS L 114 SHEET 3 AD5 3 LYS L 119 SER L 120 -1 O LYS L 119 N VAL L 107 SHEET 1 AD6 7 LYS L 114 PRO L 115 0 SHEET 2 AD6 7 ILE L 106 VAL L 111 -1 N VAL L 111 O LYS L 114 SHEET 3 AD6 7 VAL L 94 GLU L 101 -1 N CYS L 97 O TRP L 110 SHEET 4 AD6 7 ALA L 32 THR L 41 -1 N PHE L 39 O VAL L 94 SHEET 5 AD6 7 GLY L 154 MET L 161 -1 O ASP L 155 N TYR L 40 SHEET 6 AD6 7 LYS L 7 PHE L 11 -1 N PHE L 11 O GLY L 154 SHEET 7 AD6 7 PHE L 199 PRO L 202 -1 O LYS L 201 N ALA L 8 SHEET 1 AD7 7 SER L 80 GLU L 85 0 SHEET 2 AD7 7 GLY L 72 VAL L 77 -1 N TYR L 73 O PHE L 84 SHEET 3 AD7 7 GLN L 59 SER L 68 -1 N PHE L 66 O SER L 74 SHEET 4 AD7 7 TYR L 49 THR L 56 -1 N TYR L 54 O ILE L 63 SHEET 5 AD7 7 SER L 132 LEU L 135 -1 O SER L 132 N ALA L 55 SHEET 6 AD7 7 TYR L 19 LEU L 22 -1 N VAL L 20 O LEU L 135 SHEET 7 AD7 7 TYR L 192 GLN L 195 -1 O GLN L 195 N TYR L 19 SHEET 1 AD8 4 GLN M 5 SER M 9 0 SHEET 2 AD8 4 SER M 19 SER M 27 -1 O ALA M 25 N VAL M 7 SHEET 3 AD8 4 THR M 80 ASN M 86 -1 O LEU M 83 N LEU M 22 SHEET 4 AD8 4 PHE M 70 ASP M 75 -1 N ASP M 75 O THR M 80 SHEET 1 AD9 6 GLY M 12 GLN M 15 0 SHEET 2 AD9 6 THR M 122 SER M 127 1 O THR M 125 N GLY M 12 SHEET 3 AD9 6 LEU M 95 ALA M 99 -1 N TYR M 96 O THR M 122 SHEET 4 AD9 6 MET M 36 GLN M 41 -1 N PHE M 39 O TYR M 97 SHEET 5 AD9 6 ARG M 47 ILE M 53 -1 O GLU M 48 N ARG M 40 SHEET 6 AD9 6 ASP M 61 TYR M 62 -1 O ASP M 61 N SER M 52 SHEET 1 AE1 3 LYS N 114 PRO N 115 0 SHEET 2 AE1 3 ILE N 106 VAL N 111 -1 N VAL N 111 O LYS N 114 SHEET 3 AE1 3 LYS N 119 SER N 120 -1 O LYS N 119 N VAL N 107 SHEET 1 AE2 7 LYS N 114 PRO N 115 0 SHEET 2 AE2 7 ILE N 106 VAL N 111 -1 N VAL N 111 O LYS N 114 SHEET 3 AE2 7 VAL N 94 GLU N 101 -1 N CYS N 97 O TRP N 110 SHEET 4 AE2 7 ALA N 32 TYR N 40 -1 N PHE N 39 O VAL N 94 SHEET 5 AE2 7 GLY N 154 MET N 161 -1 O ASN N 160 N CYS N 36 SHEET 6 AE2 7 LYS N 7 PHE N 11 -1 N PHE N 9 O ILE N 156 SHEET 7 AE2 7 PHE N 199 PRO N 202 -1 O LYS N 201 N ALA N 8 SHEET 1 AE3 7 SER N 80 GLU N 85 0 SHEET 2 AE3 7 GLY N 72 VAL N 77 -1 N TYR N 73 O PHE N 84 SHEET 3 AE3 7 GLN N 59 SER N 68 -1 N PHE N 66 O SER N 74 SHEET 4 AE3 7 TYR N 49 THR N 56 -1 N TYR N 54 O ILE N 63 SHEET 5 AE3 7 SER N 132 LEU N 135 -1 O SER N 132 N ALA N 55 SHEET 6 AE3 7 TYR N 19 LEU N 22 -1 N VAL N 20 O LEU N 135 SHEET 7 AE3 7 TYR N 192 GLN N 195 -1 O GLN N 195 N TYR N 19 SHEET 1 AE4 4 GLN P 5 SER P 9 0 SHEET 2 AE4 4 SER P 19 SER P 27 -1 O ALA P 25 N VAL P 7 SHEET 3 AE4 4 THR P 80 ASN P 86 -1 O LEU P 83 N LEU P 22 SHEET 4 AE4 4 PHE P 70 ASP P 75 -1 N THR P 71 O GLN P 84 SHEET 1 AE5 6 GLY P 12 GLN P 15 0 SHEET 2 AE5 6 THR P 122 SER P 127 1 O THR P 125 N GLY P 12 SHEET 3 AE5 6 ALA P 94 ALA P 99 -1 N TYR P 96 O THR P 122 SHEET 4 AE5 6 GLY P 37 GLN P 41 -1 N GLN P 41 O LEU P 95 SHEET 5 AE5 6 ARG P 47 ILE P 53 -1 O GLU P 48 N ARG P 40 SHEET 6 AE5 6 LYS P 60 TYR P 62 -1 O ASP P 61 N SER P 52 SHEET 1 AE6 3 LYS Q 114 PRO Q 115 0 SHEET 2 AE6 3 ILE Q 106 VAL Q 111 -1 N VAL Q 111 O LYS Q 114 SHEET 3 AE6 3 LYS Q 119 SER Q 120 -1 O LYS Q 119 N VAL Q 107 SHEET 1 AE7 7 LYS Q 114 PRO Q 115 0 SHEET 2 AE7 7 ILE Q 106 VAL Q 111 -1 N VAL Q 111 O LYS Q 114 SHEET 3 AE7 7 VAL Q 94 GLU Q 101 -1 N CYS Q 97 O TRP Q 110 SHEET 4 AE7 7 ALA Q 32 THR Q 41 -1 N PHE Q 39 O VAL Q 94 SHEET 5 AE7 7 GLY Q 154 MET Q 161 -1 O ASN Q 160 N CYS Q 36 SHEET 6 AE7 7 LYS Q 7 PHE Q 11 -1 N PHE Q 9 O ILE Q 156 SHEET 7 AE7 7 PHE Q 199 PRO Q 202 -1 O LYS Q 201 N ALA Q 8 SHEET 1 AE8 7 SER Q 80 GLU Q 85 0 SHEET 2 AE8 7 GLY Q 72 VAL Q 77 -1 N TYR Q 73 O PHE Q 84 SHEET 3 AE8 7 GLN Q 59 SER Q 68 -1 N PHE Q 66 O SER Q 74 SHEET 4 AE8 7 TYR Q 49 THR Q 56 -1 N TYR Q 54 O ILE Q 63 SHEET 5 AE8 7 SER Q 132 LEU Q 135 -1 O SER Q 132 N ALA Q 55 SHEET 6 AE8 7 TYR Q 19 LEU Q 22 -1 N VAL Q 20 O LEU Q 135 SHEET 7 AE8 7 TYR Q 192 GLN Q 195 -1 O GLN Q 195 N TYR Q 19 SHEET 1 AE9 4 GLN R 5 SER R 9 0 SHEET 2 AE9 4 SER R 19 SER R 27 -1 O ALA R 25 N VAL R 7 SHEET 3 AE9 4 THR R 80 ASN R 86 -1 O MET R 85 N LEU R 20 SHEET 4 AE9 4 PHE R 70 ASP R 75 -1 N SER R 73 O TYR R 82 SHEET 1 AF1 6 GLY R 12 GLN R 15 0 SHEET 2 AF1 6 THR R 122 SER R 127 1 O THR R 125 N GLY R 12 SHEET 3 AF1 6 ALA R 94 SER R 101 -1 N ALA R 94 O VAL R 124 SHEET 4 AF1 6 TYR R 35 GLN R 41 -1 N GLY R 37 O ALA R 99 SHEET 5 AF1 6 ARG R 47 ILE R 53 -1 O GLU R 48 N ARG R 40 SHEET 6 AF1 6 LYS R 60 TYR R 62 -1 O ASP R 61 N SER R 52 SHEET 1 AF2 4 GLY R 12 GLN R 15 0 SHEET 2 AF2 4 THR R 122 SER R 127 1 O THR R 125 N GLY R 12 SHEET 3 AF2 4 ALA R 94 SER R 101 -1 N ALA R 94 O VAL R 124 SHEET 4 AF2 4 TYR R 117 TRP R 118 -1 O TYR R 117 N GLY R 100 SHEET 1 AF3 3 LYS T 114 PRO T 115 0 SHEET 2 AF3 3 ILE T 106 VAL T 111 -1 N VAL T 111 O LYS T 114 SHEET 3 AF3 3 LYS T 119 SER T 120 -1 O LYS T 119 N VAL T 107 SHEET 1 AF4 7 LYS T 114 PRO T 115 0 SHEET 2 AF4 7 ILE T 106 VAL T 111 -1 N VAL T 111 O LYS T 114 SHEET 3 AF4 7 VAL T 94 GLU T 101 -1 N CYS T 97 O TRP T 110 SHEET 4 AF4 7 ALA T 32 TYR T 40 -1 N PHE T 39 O VAL T 94 SHEET 5 AF4 7 GLY T 154 MET T 161 -1 O ASP T 155 N TYR T 40 SHEET 6 AF4 7 LYS T 7 PHE T 11 -1 N PHE T 11 O GLY T 154 SHEET 7 AF4 7 PHE T 199 PRO T 202 -1 O LYS T 201 N ALA T 8 SHEET 1 AF5 7 SER T 80 GLU T 85 0 SHEET 2 AF5 7 GLY T 72 VAL T 77 -1 N TYR T 73 O PHE T 84 SHEET 3 AF5 7 GLN T 59 SER T 68 -1 N PHE T 66 O SER T 74 SHEET 4 AF5 7 TYR T 49 THR T 56 -1 N TYR T 54 O ILE T 63 SHEET 5 AF5 7 SER T 132 LEU T 135 -1 O SER T 132 N ALA T 55 SHEET 6 AF5 7 TYR T 19 LEU T 22 -1 N VAL T 20 O LEU T 135 SHEET 7 AF5 7 TYR T 192 GLN T 195 -1 O GLN T 195 N TYR T 19 SSBOND 1 CYS O 24 CYS O 98 1555 1555 2.69 SSBOND 2 CYS S 36 CYS S 97 1555 1555 2.34 SSBOND 3 CYS B 36 CYS B 97 1555 1555 2.39 SSBOND 4 CYS C 24 CYS C 98 1555 1555 2.31 SSBOND 5 CYS D 36 CYS D 97 1555 1555 2.36 SSBOND 6 CYS E 24 CYS E 98 1555 1555 2.22 SSBOND 7 CYS F 36 CYS F 97 1555 1555 2.39 SSBOND 8 CYS G 24 CYS G 98 1555 1555 2.32 SSBOND 9 CYS H 36 CYS H 97 1555 1555 2.35 SSBOND 10 CYS I 24 CYS I 98 1555 1555 2.37 SSBOND 11 CYS J 36 CYS J 97 1555 1555 2.35 SSBOND 12 CYS K 24 CYS K 98 1555 1555 2.34 SSBOND 13 CYS L 36 CYS L 97 1555 1555 2.35 SSBOND 14 CYS N 36 CYS N 97 1555 1555 2.35 SSBOND 15 CYS P 24 CYS P 98 1555 1555 2.41 SSBOND 16 CYS Q 36 CYS Q 97 1555 1555 2.35 SSBOND 17 CYS T 36 CYS T 97 1555 1555 2.35 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000