HEADER IMMUNE SYSTEM 12-OCT-24 9JY1 TITLE DELTA EPSILON/DELTA EPSILON FAB-TCR TETRAMER COMPND MOL_ID: 1; COMPND 2 MOLECULE: FAB HEAVY CHAIN; COMPND 3 CHAIN: P, R; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: FAB LIGHT CHAIN; COMPND 7 CHAIN: O, Q; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; COMPND 11 CHAIN: a, b, A, B; COMPND 12 SYNONYM: T-CELL RECEPTOR T3 ZETA CHAIN; COMPND 13 ENGINEERED: YES; COMPND 14 MOL_ID: 4; COMPND 15 MOLECULE: T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN; COMPND 16 CHAIN: d, D; COMPND 17 SYNONYM: T-CELL RECEPTOR T3 DELTA CHAIN; COMPND 18 ENGINEERED: YES; COMPND 19 MOL_ID: 5; COMPND 20 MOLECULE: T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN; COMPND 21 CHAIN: e, f, E, F; COMPND 22 SYNONYM: T-CELL SURFACE ANTIGEN T3/LEU-4 EPSILON CHAIN; COMPND 23 ENGINEERED: YES; COMPND 24 MOL_ID: 6; COMPND 25 MOLECULE: T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN; COMPND 26 CHAIN: g, G; COMPND 27 SYNONYM: T-CELL RECEPTOR T3 GAMMA CHAIN; COMPND 28 ENGINEERED: YES; COMPND 29 MOL_ID: 7; COMPND 30 MOLECULE: CDNA FLJ52576; COMPND 31 CHAIN: m, M; COMPND 32 SYNONYM: TCR DELTA; COMPND 33 ENGINEERED: YES; COMPND 34 MOL_ID: 8; COMPND 35 MOLECULE: T CELL RECEPTOR GAMMA VARIABLE 9,T CELL RECEPTOR GAMMA COMPND 36 CONSTANT 1; COMPND 37 CHAIN: n, N; COMPND 38 SYNONYM: TCR GAMMA; COMPND 39 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_COMMON: HUMAN; SOURCE 10 ORGANISM_TAXID: 9606; SOURCE 11 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_COMMON: HUMAN; SOURCE 16 ORGANISM_TAXID: 9606; SOURCE 17 GENE: CD247, CD3Z, T3Z, TCRZ; SOURCE 18 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 20 MOL_ID: 4; SOURCE 21 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 22 ORGANISM_COMMON: HUMAN; SOURCE 23 ORGANISM_TAXID: 9606; SOURCE 24 GENE: CD3D, T3D; SOURCE 25 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 27 MOL_ID: 5; SOURCE 28 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 29 ORGANISM_COMMON: HUMAN; SOURCE 30 ORGANISM_TAXID: 9606; SOURCE 31 GENE: CD3E, T3E; SOURCE 32 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 33 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 34 MOL_ID: 6; SOURCE 35 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 36 ORGANISM_COMMON: HUMAN; SOURCE 37 ORGANISM_TAXID: 9606; SOURCE 38 GENE: CD3G, T3G; SOURCE 39 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 40 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 41 MOL_ID: 7; SOURCE 42 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 43 ORGANISM_COMMON: HUMAN; SOURCE 44 ORGANISM_TAXID: 9606; SOURCE 45 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 46 EXPRESSION_SYSTEM_TAXID: 40674; SOURCE 47 MOL_ID: 8; SOURCE 48 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 49 ORGANISM_COMMON: HUMAN; SOURCE 50 ORGANISM_TAXID: 9606; SOURCE 51 GENE: TRGV9, TCRGV9, TRGC1, TCRGC1; SOURCE 52 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 53 EXPRESSION_SYSTEM_TAXID: 40674 KEYWDS T CELL RECEPTOR, GAMMA DELTA TCR, IMMUNE CELL, FAB COMPLEX, IMMUNE KEYWDS 2 SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR L.WANG,J.LI,Z.LI REVDAT 1 22-OCT-25 9JY1 0 JRNL AUTH L.WANG,Z.LI,Y.FAN,J.LI JRNL TITL STRUCTURES OF THE APO AND AGONIST-CROSSLINKED HUMAN GAMMA JRNL TITL 2 DELTA T-CELL RECEPTOR JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.08 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.080 REMARK 3 NUMBER OF PARTICLES : 66511 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9JY1 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 15-OCT-24. REMARK 100 THE DEPOSITION ID IS D_1300052382. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : DELTA EPSILON/DELTA EPSILON FAB REMARK 245 -TCR TETRAMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1400.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1800.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: EICOSAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: P, O, a, b, d, e, f, g, m, n, REMARK 350 AND CHAINS: R, Q, A, B, D, E, F, G, M, N REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLY P 136 REMARK 465 SER P 137 REMARK 465 ALA P 138 REMARK 465 ALA P 139 REMARK 465 GLN P 140 REMARK 465 THR P 141 REMARK 465 ASN P 142 REMARK 465 SER P 143 REMARK 465 GLY P 166 REMARK 465 SER P 167 REMARK 465 LEU P 168 REMARK 465 SER P 169 REMARK 465 SER P 170 REMARK 465 GLY P 171 REMARK 465 THR P 191 REMARK 465 VAL P 192 REMARK 465 PRO P 193 REMARK 465 SER P 194 REMARK 465 SER P 195 REMARK 465 PRO P 196 REMARK 465 ARG P 197 REMARK 465 PRO P 198 REMARK 465 SER P 199 REMARK 465 GLU P 200 REMARK 465 THR P 201 REMARK 465 ARG P 222 REMARK 465 THR O 201 REMARK 465 SER O 202 REMARK 465 THR O 203 REMARK 465 MET a 1 REMARK 465 LYS a 2 REMARK 465 TRP a 3 REMARK 465 LYS a 4 REMARK 465 ALA a 5 REMARK 465 LEU a 6 REMARK 465 PHE a 7 REMARK 465 THR a 8 REMARK 465 ALA a 9 REMARK 465 ALA a 10 REMARK 465 ILE a 11 REMARK 465 LEU a 12 REMARK 465 GLN a 13 REMARK 465 ALA a 14 REMARK 465 GLN a 15 REMARK 465 LEU a 16 REMARK 465 PRO a 17 REMARK 465 ILE a 18 REMARK 465 THR a 19 REMARK 465 GLU a 20 REMARK 465 ALA a 21 REMARK 465 GLN a 22 REMARK 465 SER a 23 REMARK 465 PHE a 24 REMARK 465 GLY a 25 REMARK 465 ARG a 57 REMARK 465 SER a 58 REMARK 465 ALA a 59 REMARK 465 ASP a 60 REMARK 465 ALA a 61 REMARK 465 PRO a 62 REMARK 465 ALA a 63 REMARK 465 TYR a 64 REMARK 465 GLN a 65 REMARK 465 GLN a 66 REMARK 465 GLY a 67 REMARK 465 GLN a 68 REMARK 465 ASN a 69 REMARK 465 GLN a 70 REMARK 465 LEU a 71 REMARK 465 TYR a 72 REMARK 465 ASN a 73 REMARK 465 GLU a 74 REMARK 465 LEU a 75 REMARK 465 ASN a 76 REMARK 465 LEU a 77 REMARK 465 GLY a 78 REMARK 465 ARG a 79 REMARK 465 ARG a 80 REMARK 465 GLU a 81 REMARK 465 GLU a 82 REMARK 465 TYR a 83 REMARK 465 ASP a 84 REMARK 465 VAL a 85 REMARK 465 LEU a 86 REMARK 465 ASP a 87 REMARK 465 LYS a 88 REMARK 465 ARG a 89 REMARK 465 ARG a 90 REMARK 465 GLY a 91 REMARK 465 ARG a 92 REMARK 465 ASP a 93 REMARK 465 PRO a 94 REMARK 465 GLU a 95 REMARK 465 MET a 96 REMARK 465 GLY a 97 REMARK 465 GLY a 98 REMARK 465 LYS a 99 REMARK 465 PRO a 100 REMARK 465 GLN a 101 REMARK 465 ARG a 102 REMARK 465 ARG a 103 REMARK 465 LYS a 104 REMARK 465 ASN a 105 REMARK 465 PRO a 106 REMARK 465 GLN a 107 REMARK 465 GLU a 108 REMARK 465 GLY a 109 REMARK 465 LEU a 110 REMARK 465 TYR a 111 REMARK 465 ASN a 112 REMARK 465 GLU a 113 REMARK 465 LEU a 114 REMARK 465 GLN a 115 REMARK 465 LYS a 116 REMARK 465 ASP a 117 REMARK 465 LYS a 118 REMARK 465 MET a 119 REMARK 465 ALA a 120 REMARK 465 GLU a 121 REMARK 465 ALA a 122 REMARK 465 TYR a 123 REMARK 465 SER a 124 REMARK 465 GLU a 125 REMARK 465 ILE a 126 REMARK 465 GLY a 127 REMARK 465 MET a 128 REMARK 465 LYS a 129 REMARK 465 GLY a 130 REMARK 465 GLU a 131 REMARK 465 ARG a 132 REMARK 465 ARG a 133 REMARK 465 ARG a 134 REMARK 465 GLY a 135 REMARK 465 LYS a 136 REMARK 465 GLY a 137 REMARK 465 HIS a 138 REMARK 465 ASP a 139 REMARK 465 GLY a 140 REMARK 465 LEU a 141 REMARK 465 TYR a 142 REMARK 465 GLN a 143 REMARK 465 GLY a 144 REMARK 465 LEU a 145 REMARK 465 SER a 146 REMARK 465 THR a 147 REMARK 465 ALA a 148 REMARK 465 THR a 149 REMARK 465 LYS a 150 REMARK 465 ASP a 151 REMARK 465 THR a 152 REMARK 465 TYR a 153 REMARK 465 ASP a 154 REMARK 465 ALA a 155 REMARK 465 LEU a 156 REMARK 465 HIS a 157 REMARK 465 MET a 158 REMARK 465 GLN a 159 REMARK 465 ALA a 160 REMARK 465 LEU a 161 REMARK 465 PRO a 162 REMARK 465 PRO a 163 REMARK 465 ARG a 164 REMARK 465 SER a 165 REMARK 465 ALA a 166 REMARK 465 MET b 1 REMARK 465 LYS b 2 REMARK 465 TRP b 3 REMARK 465 LYS b 4 REMARK 465 ALA b 5 REMARK 465 LEU b 6 REMARK 465 PHE b 7 REMARK 465 THR b 8 REMARK 465 ALA b 9 REMARK 465 ALA b 10 REMARK 465 ILE b 11 REMARK 465 LEU b 12 REMARK 465 GLN b 13 REMARK 465 ALA b 14 REMARK 465 GLN b 15 REMARK 465 LEU b 16 REMARK 465 PRO b 17 REMARK 465 ILE b 18 REMARK 465 THR b 19 REMARK 465 GLU b 20 REMARK 465 ALA b 21 REMARK 465 GLN b 22 REMARK 465 SER b 23 REMARK 465 PHE b 24 REMARK 465 GLY b 25 REMARK 465 LEU b 26 REMARK 465 SER b 56 REMARK 465 ARG b 57 REMARK 465 SER b 58 REMARK 465 ALA b 59 REMARK 465 ASP b 60 REMARK 465 ALA b 61 REMARK 465 PRO b 62 REMARK 465 ALA b 63 REMARK 465 TYR b 64 REMARK 465 GLN b 65 REMARK 465 GLN b 66 REMARK 465 GLY b 67 REMARK 465 GLN b 68 REMARK 465 ASN b 69 REMARK 465 GLN b 70 REMARK 465 LEU b 71 REMARK 465 TYR b 72 REMARK 465 ASN b 73 REMARK 465 GLU b 74 REMARK 465 LEU b 75 REMARK 465 ASN b 76 REMARK 465 LEU b 77 REMARK 465 GLY b 78 REMARK 465 ARG b 79 REMARK 465 ARG b 80 REMARK 465 GLU b 81 REMARK 465 GLU b 82 REMARK 465 TYR b 83 REMARK 465 ASP b 84 REMARK 465 VAL b 85 REMARK 465 LEU b 86 REMARK 465 ASP b 87 REMARK 465 LYS b 88 REMARK 465 ARG b 89 REMARK 465 ARG b 90 REMARK 465 GLY b 91 REMARK 465 ARG b 92 REMARK 465 ASP b 93 REMARK 465 PRO b 94 REMARK 465 GLU b 95 REMARK 465 MET b 96 REMARK 465 GLY b 97 REMARK 465 GLY b 98 REMARK 465 LYS b 99 REMARK 465 PRO b 100 REMARK 465 GLN b 101 REMARK 465 ARG b 102 REMARK 465 ARG b 103 REMARK 465 LYS b 104 REMARK 465 ASN b 105 REMARK 465 PRO b 106 REMARK 465 GLN b 107 REMARK 465 GLU b 108 REMARK 465 GLY b 109 REMARK 465 LEU b 110 REMARK 465 TYR b 111 REMARK 465 ASN b 112 REMARK 465 GLU b 113 REMARK 465 LEU b 114 REMARK 465 GLN b 115 REMARK 465 LYS b 116 REMARK 465 ASP b 117 REMARK 465 LYS b 118 REMARK 465 MET b 119 REMARK 465 ALA b 120 REMARK 465 GLU b 121 REMARK 465 ALA b 122 REMARK 465 TYR b 123 REMARK 465 SER b 124 REMARK 465 GLU b 125 REMARK 465 ILE b 126 REMARK 465 GLY b 127 REMARK 465 MET b 128 REMARK 465 LYS b 129 REMARK 465 GLY b 130 REMARK 465 GLU b 131 REMARK 465 ARG b 132 REMARK 465 ARG b 133 REMARK 465 ARG b 134 REMARK 465 GLY b 135 REMARK 465 LYS b 136 REMARK 465 GLY b 137 REMARK 465 HIS b 138 REMARK 465 ASP b 139 REMARK 465 GLY b 140 REMARK 465 LEU b 141 REMARK 465 TYR b 142 REMARK 465 GLN b 143 REMARK 465 GLY b 144 REMARK 465 LEU b 145 REMARK 465 SER b 146 REMARK 465 THR b 147 REMARK 465 ALA b 148 REMARK 465 THR b 149 REMARK 465 LYS b 150 REMARK 465 ASP b 151 REMARK 465 THR b 152 REMARK 465 TYR b 153 REMARK 465 ASP b 154 REMARK 465 ALA b 155 REMARK 465 LEU b 156 REMARK 465 HIS b 157 REMARK 465 MET b 158 REMARK 465 GLN b 159 REMARK 465 ALA b 160 REMARK 465 LEU b 161 REMARK 465 PRO b 162 REMARK 465 PRO b 163 REMARK 465 ARG b 164 REMARK 465 SER b 165 REMARK 465 ALA b 166 REMARK 465 MET d 1 REMARK 465 GLU d 2 REMARK 465 HIS d 3 REMARK 465 SER d 4 REMARK 465 THR d 5 REMARK 465 PHE d 6 REMARK 465 LEU d 7 REMARK 465 SER d 8 REMARK 465 GLY d 9 REMARK 465 LEU d 10 REMARK 465 VAL d 11 REMARK 465 LEU d 12 REMARK 465 ALA d 13 REMARK 465 THR d 14 REMARK 465 LEU d 15 REMARK 465 LEU d 16 REMARK 465 SER d 17 REMARK 465 GLN d 18 REMARK 465 VAL d 19 REMARK 465 SER d 20 REMARK 465 PRO d 21 REMARK 465 GLY d 127 REMARK 465 HIS d 128 REMARK 465 GLU d 129 REMARK 465 THR d 130 REMARK 465 GLY d 131 REMARK 465 ARG d 132 REMARK 465 LEU d 133 REMARK 465 SER d 134 REMARK 465 GLY d 135 REMARK 465 ALA d 136 REMARK 465 ALA d 137 REMARK 465 ASP d 138 REMARK 465 THR d 139 REMARK 465 GLN d 140 REMARK 465 ALA d 141 REMARK 465 LEU d 142 REMARK 465 LEU d 143 REMARK 465 ARG d 144 REMARK 465 ASN d 145 REMARK 465 ASP d 146 REMARK 465 GLN d 147 REMARK 465 VAL d 148 REMARK 465 TYR d 149 REMARK 465 GLN d 150 REMARK 465 PRO d 151 REMARK 465 LEU d 152 REMARK 465 ARG d 153 REMARK 465 ASP d 154 REMARK 465 ARG d 155 REMARK 465 ASP d 156 REMARK 465 ASP d 157 REMARK 465 ALA d 158 REMARK 465 GLN d 159 REMARK 465 TYR d 160 REMARK 465 SER d 161 REMARK 465 HIS d 162 REMARK 465 LEU d 163 REMARK 465 GLY d 164 REMARK 465 GLY d 165 REMARK 465 ASN d 166 REMARK 465 TRP d 167 REMARK 465 ALA d 168 REMARK 465 ARG d 169 REMARK 465 ASN d 170 REMARK 465 LYS d 171 REMARK 465 MET e 1 REMARK 465 GLN e 2 REMARK 465 SER e 3 REMARK 465 GLY e 4 REMARK 465 THR e 5 REMARK 465 HIS e 6 REMARK 465 TRP e 7 REMARK 465 ARG e 8 REMARK 465 VAL e 9 REMARK 465 LEU e 10 REMARK 465 GLY e 11 REMARK 465 LEU e 12 REMARK 465 CYS e 13 REMARK 465 LEU e 14 REMARK 465 LEU e 15 REMARK 465 SER e 16 REMARK 465 VAL e 17 REMARK 465 GLY e 18 REMARK 465 VAL e 19 REMARK 465 TRP e 20 REMARK 465 GLY e 21 REMARK 465 GLN e 22 REMARK 465 ASP e 23 REMARK 465 GLY e 24 REMARK 465 ASN e 25 REMARK 465 GLU e 26 REMARK 465 GLU e 27 REMARK 465 MET e 28 REMARK 465 GLY e 29 REMARK 465 GLY e 30 REMARK 465 ILE e 31 REMARK 465 THR e 32 REMARK 465 ASN e 154 REMARK 465 ARG e 155 REMARK 465 LYS e 156 REMARK 465 ALA e 157 REMARK 465 LYS e 158 REMARK 465 ALA e 159 REMARK 465 LYS e 160 REMARK 465 PRO e 161 REMARK 465 VAL e 162 REMARK 465 THR e 163 REMARK 465 ARG e 164 REMARK 465 GLY e 165 REMARK 465 ALA e 166 REMARK 465 GLY e 167 REMARK 465 ALA e 168 REMARK 465 GLY e 169 REMARK 465 GLY e 170 REMARK 465 ARG e 171 REMARK 465 GLN e 172 REMARK 465 ARG e 173 REMARK 465 GLY e 174 REMARK 465 GLN e 175 REMARK 465 ASN e 176 REMARK 465 LYS e 177 REMARK 465 GLU e 178 REMARK 465 ARG e 179 REMARK 465 PRO e 180 REMARK 465 PRO e 181 REMARK 465 PRO e 182 REMARK 465 VAL e 183 REMARK 465 PRO e 184 REMARK 465 ASN e 185 REMARK 465 PRO e 186 REMARK 465 ASP e 187 REMARK 465 TYR e 188 REMARK 465 GLU e 189 REMARK 465 PRO e 190 REMARK 465 ILE e 191 REMARK 465 ARG e 192 REMARK 465 LYS e 193 REMARK 465 GLY e 194 REMARK 465 GLN e 195 REMARK 465 ARG e 196 REMARK 465 ASP e 197 REMARK 465 LEU e 198 REMARK 465 TYR e 199 REMARK 465 SER e 200 REMARK 465 GLY e 201 REMARK 465 LEU e 202 REMARK 465 ASN e 203 REMARK 465 GLN e 204 REMARK 465 ARG e 205 REMARK 465 ARG e 206 REMARK 465 ILE e 207 REMARK 465 MET f 1 REMARK 465 GLN f 2 REMARK 465 SER f 3 REMARK 465 GLY f 4 REMARK 465 THR f 5 REMARK 465 HIS f 6 REMARK 465 TRP f 7 REMARK 465 ARG f 8 REMARK 465 VAL f 9 REMARK 465 LEU f 10 REMARK 465 GLY f 11 REMARK 465 LEU f 12 REMARK 465 CYS f 13 REMARK 465 LEU f 14 REMARK 465 LEU f 15 REMARK 465 SER f 16 REMARK 465 VAL f 17 REMARK 465 GLY f 18 REMARK 465 VAL f 19 REMARK 465 TRP f 20 REMARK 465 GLY f 21 REMARK 465 GLN f 22 REMARK 465 ASP f 23 REMARK 465 GLY f 24 REMARK 465 ASN f 25 REMARK 465 GLU f 26 REMARK 465 GLU f 27 REMARK 465 MET f 28 REMARK 465 GLY f 29 REMARK 465 GLY f 30 REMARK 465 ILE f 31 REMARK 465 THR f 32 REMARK 465 GLU f 70 REMARK 465 ASP f 71 REMARK 465 ASP f 72 REMARK 465 LYS f 73 REMARK 465 ARG f 155 REMARK 465 LYS f 156 REMARK 465 ALA f 157 REMARK 465 LYS f 158 REMARK 465 ALA f 159 REMARK 465 LYS f 160 REMARK 465 PRO f 161 REMARK 465 VAL f 162 REMARK 465 THR f 163 REMARK 465 ARG f 164 REMARK 465 GLY f 165 REMARK 465 ALA f 166 REMARK 465 GLY f 167 REMARK 465 ALA f 168 REMARK 465 GLY f 169 REMARK 465 GLY f 170 REMARK 465 ARG f 171 REMARK 465 GLN f 172 REMARK 465 ARG f 173 REMARK 465 GLY f 174 REMARK 465 GLN f 175 REMARK 465 ASN f 176 REMARK 465 LYS f 177 REMARK 465 GLU f 178 REMARK 465 ARG f 179 REMARK 465 PRO f 180 REMARK 465 PRO f 181 REMARK 465 PRO f 182 REMARK 465 VAL f 183 REMARK 465 PRO f 184 REMARK 465 ASN f 185 REMARK 465 PRO f 186 REMARK 465 ASP f 187 REMARK 465 TYR f 188 REMARK 465 GLU f 189 REMARK 465 PRO f 190 REMARK 465 ILE f 191 REMARK 465 ARG f 192 REMARK 465 LYS f 193 REMARK 465 GLY f 194 REMARK 465 GLN f 195 REMARK 465 ARG f 196 REMARK 465 ASP f 197 REMARK 465 LEU f 198 REMARK 465 TYR f 199 REMARK 465 SER f 200 REMARK 465 GLY f 201 REMARK 465 LEU f 202 REMARK 465 ASN f 203 REMARK 465 GLN f 204 REMARK 465 ARG f 205 REMARK 465 ARG f 206 REMARK 465 ILE f 207 REMARK 465 MET g 1 REMARK 465 GLU g 2 REMARK 465 GLN g 3 REMARK 465 GLY g 4 REMARK 465 LYS g 5 REMARK 465 GLY g 6 REMARK 465 LEU g 7 REMARK 465 ALA g 8 REMARK 465 VAL g 9 REMARK 465 LEU g 10 REMARK 465 ILE g 11 REMARK 465 LEU g 12 REMARK 465 ALA g 13 REMARK 465 ILE g 14 REMARK 465 ILE g 15 REMARK 465 LEU g 16 REMARK 465 LEU g 17 REMARK 465 GLN g 18 REMARK 465 GLY g 19 REMARK 465 THR g 20 REMARK 465 LEU g 21 REMARK 465 ALA g 22 REMARK 465 GLN g 23 REMARK 465 SER g 24 REMARK 465 ILE g 25 REMARK 465 GLY g 141 REMARK 465 VAL g 142 REMARK 465 ARG g 143 REMARK 465 GLN g 144 REMARK 465 SER g 145 REMARK 465 ARG g 146 REMARK 465 ALA g 147 REMARK 465 SER g 148 REMARK 465 ASP g 149 REMARK 465 LYS g 150 REMARK 465 GLN g 151 REMARK 465 THR g 152 REMARK 465 LEU g 153 REMARK 465 LEU g 154 REMARK 465 PRO g 155 REMARK 465 ASN g 156 REMARK 465 ASP g 157 REMARK 465 GLN g 158 REMARK 465 LEU g 159 REMARK 465 TYR g 160 REMARK 465 GLN g 161 REMARK 465 PRO g 162 REMARK 465 LEU g 163 REMARK 465 LYS g 164 REMARK 465 ASP g 165 REMARK 465 ARG g 166 REMARK 465 GLU g 167 REMARK 465 ASP g 168 REMARK 465 ASP g 169 REMARK 465 GLN g 170 REMARK 465 TYR g 171 REMARK 465 SER g 172 REMARK 465 HIS g 173 REMARK 465 LEU g 174 REMARK 465 GLN g 175 REMARK 465 GLY g 176 REMARK 465 ASN g 177 REMARK 465 GLN g 178 REMARK 465 LEU g 179 REMARK 465 ARG g 180 REMARK 465 ARG g 181 REMARK 465 ASN g 182 REMARK 465 MET m -1 REMARK 465 GLN m 0 REMARK 465 ARG m 1 REMARK 465 ILE m 2 REMARK 465 SER m 3 REMARK 465 SER m 4 REMARK 465 LEU m 5 REMARK 465 ILE m 6 REMARK 465 HIS m 7 REMARK 465 LEU m 8 REMARK 465 SER m 9 REMARK 465 LEU m 10 REMARK 465 PHE m 11 REMARK 465 TRP m 12 REMARK 465 ALA m 13 REMARK 465 GLY m 14 REMARK 465 VAL m 15 REMARK 465 MET m 16 REMARK 465 SER m 17 REMARK 465 ALA m 18 REMARK 465 ILE m 19 REMARK 465 GLU m 20 REMARK 465 LEU m 21 REMARK 465 VAL m 22 REMARK 465 PRO m 23 REMARK 465 GLU m 24 REMARK 465 HIS m 25 REMARK 465 GLN m 26 REMARK 465 THR m 27 REMARK 465 VAL m 28 REMARK 465 PRO m 29 REMARK 465 VAL m 30 REMARK 465 SER m 31 REMARK 465 ILE m 32 REMARK 465 GLY m 33 REMARK 465 VAL m 34 REMARK 465 PRO m 35 REMARK 465 ALA m 36 REMARK 465 THR m 37 REMARK 465 LEU m 38 REMARK 465 ARG m 39 REMARK 465 CYS m 40 REMARK 465 SER m 41 REMARK 465 MET m 42 REMARK 465 LYS m 43 REMARK 465 GLY m 44 REMARK 465 GLU m 45 REMARK 465 ALA m 46 REMARK 465 ILE m 47 REMARK 465 GLY m 48 REMARK 465 ASN m 49 REMARK 465 TYR m 50 REMARK 465 TYR m 51 REMARK 465 ILE m 52 REMARK 465 ASN m 53 REMARK 465 TRP m 54 REMARK 465 TYR m 55 REMARK 465 ARG m 56 REMARK 465 LYS m 57 REMARK 465 THR m 58 REMARK 465 GLN m 59 REMARK 465 GLY m 60 REMARK 465 ASN m 61 REMARK 465 THR m 62 REMARK 465 MET m 63 REMARK 465 THR m 64 REMARK 465 PHE m 65 REMARK 465 ILE m 66 REMARK 465 TYR m 67 REMARK 465 ARG m 68 REMARK 465 GLU m 69 REMARK 465 LYS m 70 REMARK 465 ASP m 71 REMARK 465 ILE m 72 REMARK 465 TYR m 73 REMARK 465 GLY m 74 REMARK 465 PRO m 75 REMARK 465 GLY m 76 REMARK 465 PHE m 77 REMARK 465 LYS m 78 REMARK 465 ASP m 79 REMARK 465 ASN m 80 REMARK 465 PHE m 81 REMARK 465 GLN m 82 REMARK 465 GLY m 83 REMARK 465 ASP m 84 REMARK 465 ILE m 85 REMARK 465 ASP m 86 REMARK 465 ILE m 87 REMARK 465 ALA m 88 REMARK 465 LYS m 89 REMARK 465 ASN m 90 REMARK 465 LEU m 91 REMARK 465 ALA m 92 REMARK 465 VAL m 93 REMARK 465 LEU m 94 REMARK 465 LYS m 95 REMARK 465 ILE m 96 REMARK 465 LEU m 97 REMARK 465 ALA m 98 REMARK 465 PRO m 99 REMARK 465 SER m 100 REMARK 465 GLU m 101 REMARK 465 ARG m 102 REMARK 465 ASP m 103 REMARK 465 GLU m 104 REMARK 465 GLY m 105 REMARK 465 SER m 106 REMARK 465 TYR m 107 REMARK 465 TYR m 108 REMARK 465 CYS m 109 REMARK 465 ALA m 110 REMARK 465 CYS m 111 REMARK 465 ASP m 112 REMARK 465 THR m 113 REMARK 465 LEU m 114 REMARK 465 GLY m 115 REMARK 465 MET m 116 REMARK 465 GLY m 117 REMARK 465 GLY m 118 REMARK 465 GLU m 119 REMARK 465 TYR m 120 REMARK 465 THR m 121 REMARK 465 ASP m 122 REMARK 465 LYS m 123 REMARK 465 LEU m 124 REMARK 465 ILE m 125 REMARK 465 PHE m 126 REMARK 465 GLY m 127 REMARK 465 LYS m 128 REMARK 465 GLY m 129 REMARK 465 THR m 130 REMARK 465 ARG m 131 REMARK 465 VAL m 132 REMARK 465 THR m 133 REMARK 465 VAL m 134 REMARK 465 GLU m 135 REMARK 465 PRO m 136 REMARK 465 ARG m 137 REMARK 465 SER m 138 REMARK 465 GLN m 139 REMARK 465 PRO m 140 REMARK 465 HIS m 141 REMARK 465 THR m 142 REMARK 465 LYS m 143 REMARK 465 PRO m 144 REMARK 465 SER m 145 REMARK 465 VAL m 146 REMARK 465 PHE m 147 REMARK 465 VAL m 148 REMARK 465 MET m 149 REMARK 465 LYS m 150 REMARK 465 ASN m 151 REMARK 465 GLY m 152 REMARK 465 THR m 153 REMARK 465 ASN m 154 REMARK 465 VAL m 155 REMARK 465 ALA m 156 REMARK 465 CYS m 157 REMARK 465 LEU m 158 REMARK 465 VAL m 159 REMARK 465 LYS m 160 REMARK 465 GLU m 161 REMARK 465 PHE m 162 REMARK 465 TYR m 163 REMARK 465 PRO m 164 REMARK 465 LYS m 165 REMARK 465 ASP m 166 REMARK 465 ILE m 167 REMARK 465 ARG m 168 REMARK 465 ILE m 169 REMARK 465 ASN m 170 REMARK 465 LEU m 171 REMARK 465 VAL m 172 REMARK 465 SER m 173 REMARK 465 SER m 174 REMARK 465 LYS m 175 REMARK 465 LYS m 176 REMARK 465 ILE m 177 REMARK 465 THR m 178 REMARK 465 GLU m 179 REMARK 465 PHE m 180 REMARK 465 ASP m 181 REMARK 465 PRO m 182 REMARK 465 ALA m 183 REMARK 465 ILE m 184 REMARK 465 VAL m 185 REMARK 465 ILE m 186 REMARK 465 SER m 187 REMARK 465 PRO m 188 REMARK 465 SER m 189 REMARK 465 GLY m 190 REMARK 465 LYS m 191 REMARK 465 TYR m 192 REMARK 465 ASN m 193 REMARK 465 ALA m 194 REMARK 465 VAL m 195 REMARK 465 LYS m 196 REMARK 465 LEU m 197 REMARK 465 GLY m 198 REMARK 465 LYS m 199 REMARK 465 TYR m 200 REMARK 465 GLU m 201 REMARK 465 ASP m 202 REMARK 465 SER m 203 REMARK 465 ASN m 204 REMARK 465 SER m 205 REMARK 465 VAL m 206 REMARK 465 THR m 207 REMARK 465 CYS m 208 REMARK 465 SER m 209 REMARK 465 VAL m 210 REMARK 465 GLN m 211 REMARK 465 HIS m 212 REMARK 465 ASP m 213 REMARK 465 ASN m 214 REMARK 465 LYS m 215 REMARK 465 THR m 216 REMARK 465 VAL m 217 REMARK 465 HIS m 218 REMARK 465 SER m 219 REMARK 465 THR m 220 REMARK 465 ASP m 221 REMARK 465 PHE m 222 REMARK 465 GLU m 223 REMARK 465 VAL m 224 REMARK 465 LYS m 225 REMARK 465 THR m 226 REMARK 465 ASP m 227 REMARK 465 SER m 228 REMARK 465 THR m 229 REMARK 465 ASP m 230 REMARK 465 HIS m 231 REMARK 465 VAL m 232 REMARK 465 LYS m 233 REMARK 465 PRO m 234 REMARK 465 LYS m 235 REMARK 465 GLU m 236 REMARK 465 THR m 237 REMARK 465 GLU m 238 REMARK 465 ASN m 239 REMARK 465 THR m 240 REMARK 465 LYS m 241 REMARK 465 GLN m 242 REMARK 465 PRO m 243 REMARK 465 SER m 244 REMARK 465 LYS m 245 REMARK 465 SER m 246 REMARK 465 CYS m 247 REMARK 465 HIS m 248 REMARK 465 LYS m 249 REMARK 465 PRO m 250 REMARK 465 LYS m 251 REMARK 465 ALA m 252 REMARK 465 ILE m 253 REMARK 465 LEU m 290 REMARK 465 MET n -17 REMARK 465 LEU n -16 REMARK 465 SER n -15 REMARK 465 LEU n -14 REMARK 465 LEU n -13 REMARK 465 HIS n -12 REMARK 465 THR n -11 REMARK 465 SER n -10 REMARK 465 THR n -9 REMARK 465 LEU n -8 REMARK 465 ALA n -7 REMARK 465 VAL n -6 REMARK 465 LEU n -5 REMARK 465 GLY n -4 REMARK 465 ALA n -3 REMARK 465 LEU n -2 REMARK 465 CYS n -1 REMARK 465 VAL n 0 REMARK 465 TYR n 1 REMARK 465 GLY n 2 REMARK 465 ALA n 3 REMARK 465 GLY n 4 REMARK 465 HIS n 5 REMARK 465 LEU n 6 REMARK 465 GLU n 7 REMARK 465 GLN n 8 REMARK 465 PRO n 9 REMARK 465 GLN n 10 REMARK 465 ILE n 11 REMARK 465 SER n 12 REMARK 465 SER n 13 REMARK 465 THR n 14 REMARK 465 LYS n 15 REMARK 465 THR n 16 REMARK 465 LEU n 17 REMARK 465 SER n 18 REMARK 465 LYS n 19 REMARK 465 THR n 20 REMARK 465 ALA n 21 REMARK 465 ARG n 22 REMARK 465 LEU n 23 REMARK 465 GLU n 24 REMARK 465 CYS n 25 REMARK 465 VAL n 26 REMARK 465 VAL n 27 REMARK 465 SER n 28 REMARK 465 GLY n 29 REMARK 465 ILE n 30 REMARK 465 THR n 31 REMARK 465 ILE n 32 REMARK 465 SER n 33 REMARK 465 ALA n 34 REMARK 465 THR n 35 REMARK 465 SER n 36 REMARK 465 VAL n 37 REMARK 465 TYR n 38 REMARK 465 TRP n 39 REMARK 465 TYR n 40 REMARK 465 ARG n 41 REMARK 465 GLU n 42 REMARK 465 ARG n 43 REMARK 465 PRO n 44 REMARK 465 GLY n 45 REMARK 465 GLU n 46 REMARK 465 VAL n 47 REMARK 465 ILE n 48 REMARK 465 GLN n 49 REMARK 465 PHE n 50 REMARK 465 LEU n 51 REMARK 465 VAL n 52 REMARK 465 SER n 53 REMARK 465 ILE n 54 REMARK 465 SER n 55 REMARK 465 TYR n 56 REMARK 465 ASP n 57 REMARK 465 GLY n 58 REMARK 465 THR n 59 REMARK 465 VAL n 60 REMARK 465 ARG n 61 REMARK 465 LYS n 62 REMARK 465 GLU n 63 REMARK 465 SER n 64 REMARK 465 GLY n 65 REMARK 465 ILE n 66 REMARK 465 PRO n 67 REMARK 465 SER n 68 REMARK 465 GLY n 69 REMARK 465 LYS n 70 REMARK 465 PHE n 71 REMARK 465 GLU n 72 REMARK 465 VAL n 73 REMARK 465 ASP n 74 REMARK 465 ARG n 75 REMARK 465 ILE n 76 REMARK 465 PRO n 77 REMARK 465 GLU n 78 REMARK 465 THR n 79 REMARK 465 SER n 80 REMARK 465 THR n 81 REMARK 465 SER n 82 REMARK 465 THR n 83 REMARK 465 LEU n 84 REMARK 465 THR n 85 REMARK 465 ILE n 86 REMARK 465 HIS n 87 REMARK 465 ASN n 88 REMARK 465 VAL n 89 REMARK 465 GLU n 90 REMARK 465 LYS n 91 REMARK 465 GLN n 92 REMARK 465 ASP n 93 REMARK 465 ILE n 94 REMARK 465 ALA n 95 REMARK 465 THR n 96 REMARK 465 TYR n 97 REMARK 465 TYR n 98 REMARK 465 CYS n 99 REMARK 465 ALA n 100 REMARK 465 LEU n 101 REMARK 465 TRP n 102 REMARK 465 GLU n 103 REMARK 465 ALA n 104 REMARK 465 GLN n 105 REMARK 465 GLN n 106 REMARK 465 GLU n 107 REMARK 465 LEU n 108 REMARK 465 GLY n 109 REMARK 465 LYS n 110 REMARK 465 LYS n 111 REMARK 465 ILE n 112 REMARK 465 LYS n 113 REMARK 465 VAL n 114 REMARK 465 PHE n 115 REMARK 465 GLY n 116 REMARK 465 PRO n 117 REMARK 465 GLY n 118 REMARK 465 THR n 119 REMARK 465 LYS n 120 REMARK 465 LEU n 121 REMARK 465 ILE n 122 REMARK 465 ILE n 123 REMARK 465 THR n 124 REMARK 465 ASP n 125 REMARK 465 LYS n 126 REMARK 465 GLN n 127 REMARK 465 LEU n 128 REMARK 465 ASP n 129 REMARK 465 ALA n 130 REMARK 465 ASP n 131 REMARK 465 VAL n 132 REMARK 465 SER n 133 REMARK 465 PRO n 134 REMARK 465 LYS n 135 REMARK 465 PRO n 136 REMARK 465 THR n 137 REMARK 465 ILE n 138 REMARK 465 PHE n 139 REMARK 465 LEU n 140 REMARK 465 PRO n 141 REMARK 465 SER n 142 REMARK 465 ILE n 143 REMARK 465 ALA n 144 REMARK 465 GLU n 145 REMARK 465 THR n 146 REMARK 465 LYS n 147 REMARK 465 LEU n 148 REMARK 465 GLN n 149 REMARK 465 LYS n 150 REMARK 465 ALA n 151 REMARK 465 GLY n 152 REMARK 465 THR n 153 REMARK 465 TYR n 154 REMARK 465 LEU n 155 REMARK 465 CYS n 156 REMARK 465 LEU n 157 REMARK 465 LEU n 158 REMARK 465 GLU n 159 REMARK 465 LYS n 160 REMARK 465 PHE n 161 REMARK 465 PHE n 162 REMARK 465 PRO n 163 REMARK 465 ASP n 164 REMARK 465 VAL n 165 REMARK 465 ILE n 166 REMARK 465 LYS n 167 REMARK 465 ILE n 168 REMARK 465 HIS n 169 REMARK 465 TRP n 170 REMARK 465 GLU n 171 REMARK 465 GLU n 172 REMARK 465 LYS n 173 REMARK 465 LYS n 174 REMARK 465 SER n 175 REMARK 465 ASN n 176 REMARK 465 THR n 177 REMARK 465 ILE n 178 REMARK 465 LEU n 179 REMARK 465 GLY n 180 REMARK 465 SER n 181 REMARK 465 GLN n 182 REMARK 465 GLU n 183 REMARK 465 GLY n 184 REMARK 465 ASN n 185 REMARK 465 THR n 186 REMARK 465 MET n 187 REMARK 465 LYS n 188 REMARK 465 THR n 189 REMARK 465 ASN n 190 REMARK 465 ASP n 191 REMARK 465 THR n 192 REMARK 465 TYR n 193 REMARK 465 MET n 194 REMARK 465 LYS n 195 REMARK 465 PHE n 196 REMARK 465 SER n 197 REMARK 465 TRP n 198 REMARK 465 LEU n 199 REMARK 465 THR n 200 REMARK 465 VAL n 201 REMARK 465 PRO n 202 REMARK 465 GLU n 203 REMARK 465 LYS n 204 REMARK 465 SER n 205 REMARK 465 LEU n 206 REMARK 465 ASP n 207 REMARK 465 LYS n 208 REMARK 465 GLU n 209 REMARK 465 HIS n 210 REMARK 465 ARG n 211 REMARK 465 CYS n 212 REMARK 465 ILE n 213 REMARK 465 VAL n 214 REMARK 465 ARG n 215 REMARK 465 HIS n 216 REMARK 465 GLU n 217 REMARK 465 ASN n 218 REMARK 465 ASN n 219 REMARK 465 LYS n 220 REMARK 465 ASN n 221 REMARK 465 GLY n 222 REMARK 465 VAL n 223 REMARK 465 ASP n 224 REMARK 465 GLN n 225 REMARK 465 GLU n 226 REMARK 465 ILE n 227 REMARK 465 ILE n 228 REMARK 465 PHE n 229 REMARK 465 PRO n 230 REMARK 465 PRO n 231 REMARK 465 ILE n 232 REMARK 465 LYS n 233 REMARK 465 THR n 234 REMARK 465 ASP n 235 REMARK 465 VAL n 236 REMARK 465 ILE n 237 REMARK 465 THR n 238 REMARK 465 MET n 239 REMARK 465 ASP n 240 REMARK 465 PRO n 241 REMARK 465 LYS n 242 REMARK 465 ASP n 243 REMARK 465 ASN n 244 REMARK 465 CYS n 245 REMARK 465 SER n 246 REMARK 465 LYS n 247 REMARK 465 ASP n 248 REMARK 465 ALA n 249 REMARK 465 ASN n 250 REMARK 465 ALA n 289 REMARK 465 PHE n 290 REMARK 465 CYS n 291 REMARK 465 CYS n 292 REMARK 465 ASN n 293 REMARK 465 GLY n 294 REMARK 465 GLU n 295 REMARK 465 LYS n 296 REMARK 465 SER n 297 REMARK 465 GLY R 136 REMARK 465 SER R 137 REMARK 465 ALA R 138 REMARK 465 ALA R 139 REMARK 465 GLN R 140 REMARK 465 THR R 141 REMARK 465 ASN R 142 REMARK 465 SER R 143 REMARK 465 GLY R 166 REMARK 465 SER R 167 REMARK 465 LEU R 168 REMARK 465 SER R 169 REMARK 465 SER R 170 REMARK 465 GLY R 171 REMARK 465 THR R 191 REMARK 465 VAL R 192 REMARK 465 PRO R 193 REMARK 465 SER R 194 REMARK 465 SER R 195 REMARK 465 PRO R 196 REMARK 465 ARG R 197 REMARK 465 PRO R 198 REMARK 465 SER R 199 REMARK 465 GLU R 200 REMARK 465 THR R 201 REMARK 465 ARG R 222 REMARK 465 THR Q 201 REMARK 465 SER Q 202 REMARK 465 THR Q 203 REMARK 465 MET A 1 REMARK 465 LYS A 2 REMARK 465 TRP A 3 REMARK 465 LYS A 4 REMARK 465 ALA A 5 REMARK 465 LEU A 6 REMARK 465 PHE A 7 REMARK 465 THR A 8 REMARK 465 ALA A 9 REMARK 465 ALA A 10 REMARK 465 ILE A 11 REMARK 465 LEU A 12 REMARK 465 GLN A 13 REMARK 465 ALA A 14 REMARK 465 GLN A 15 REMARK 465 LEU A 16 REMARK 465 PRO A 17 REMARK 465 ILE A 18 REMARK 465 THR A 19 REMARK 465 GLU A 20 REMARK 465 ALA A 21 REMARK 465 GLN A 22 REMARK 465 SER A 23 REMARK 465 PHE A 24 REMARK 465 GLY A 25 REMARK 465 ARG A 57 REMARK 465 SER A 58 REMARK 465 ALA A 59 REMARK 465 ASP A 60 REMARK 465 ALA A 61 REMARK 465 PRO A 62 REMARK 465 ALA A 63 REMARK 465 TYR A 64 REMARK 465 GLN A 65 REMARK 465 GLN A 66 REMARK 465 GLY A 67 REMARK 465 GLN A 68 REMARK 465 ASN A 69 REMARK 465 GLN A 70 REMARK 465 LEU A 71 REMARK 465 TYR A 72 REMARK 465 ASN A 73 REMARK 465 GLU A 74 REMARK 465 LEU A 75 REMARK 465 ASN A 76 REMARK 465 LEU A 77 REMARK 465 GLY A 78 REMARK 465 ARG A 79 REMARK 465 ARG A 80 REMARK 465 GLU A 81 REMARK 465 GLU A 82 REMARK 465 TYR A 83 REMARK 465 ASP A 84 REMARK 465 VAL A 85 REMARK 465 LEU A 86 REMARK 465 ASP A 87 REMARK 465 LYS A 88 REMARK 465 ARG A 89 REMARK 465 ARG A 90 REMARK 465 GLY A 91 REMARK 465 ARG A 92 REMARK 465 ASP A 93 REMARK 465 PRO A 94 REMARK 465 GLU A 95 REMARK 465 MET A 96 REMARK 465 GLY A 97 REMARK 465 GLY A 98 REMARK 465 LYS A 99 REMARK 465 PRO A 100 REMARK 465 GLN A 101 REMARK 465 ARG A 102 REMARK 465 ARG A 103 REMARK 465 LYS A 104 REMARK 465 ASN A 105 REMARK 465 PRO A 106 REMARK 465 GLN A 107 REMARK 465 GLU A 108 REMARK 465 GLY A 109 REMARK 465 LEU A 110 REMARK 465 TYR A 111 REMARK 465 ASN A 112 REMARK 465 GLU A 113 REMARK 465 LEU A 114 REMARK 465 GLN A 115 REMARK 465 LYS A 116 REMARK 465 ASP A 117 REMARK 465 LYS A 118 REMARK 465 MET A 119 REMARK 465 ALA A 120 REMARK 465 GLU A 121 REMARK 465 ALA A 122 REMARK 465 TYR A 123 REMARK 465 SER A 124 REMARK 465 GLU A 125 REMARK 465 ILE A 126 REMARK 465 GLY A 127 REMARK 465 MET A 128 REMARK 465 LYS A 129 REMARK 465 GLY A 130 REMARK 465 GLU A 131 REMARK 465 ARG A 132 REMARK 465 ARG A 133 REMARK 465 ARG A 134 REMARK 465 GLY A 135 REMARK 465 LYS A 136 REMARK 465 GLY A 137 REMARK 465 HIS A 138 REMARK 465 ASP A 139 REMARK 465 GLY A 140 REMARK 465 LEU A 141 REMARK 465 TYR A 142 REMARK 465 GLN A 143 REMARK 465 GLY A 144 REMARK 465 LEU A 145 REMARK 465 SER A 146 REMARK 465 THR A 147 REMARK 465 ALA A 148 REMARK 465 THR A 149 REMARK 465 LYS A 150 REMARK 465 ASP A 151 REMARK 465 THR A 152 REMARK 465 TYR A 153 REMARK 465 ASP A 154 REMARK 465 ALA A 155 REMARK 465 LEU A 156 REMARK 465 HIS A 157 REMARK 465 MET A 158 REMARK 465 GLN A 159 REMARK 465 ALA A 160 REMARK 465 LEU A 161 REMARK 465 PRO A 162 REMARK 465 PRO A 163 REMARK 465 ARG A 164 REMARK 465 SER A 165 REMARK 465 ALA A 166 REMARK 465 MET B 1 REMARK 465 LYS B 2 REMARK 465 TRP B 3 REMARK 465 LYS B 4 REMARK 465 ALA B 5 REMARK 465 LEU B 6 REMARK 465 PHE B 7 REMARK 465 THR B 8 REMARK 465 ALA B 9 REMARK 465 ALA B 10 REMARK 465 ILE B 11 REMARK 465 LEU B 12 REMARK 465 GLN B 13 REMARK 465 ALA B 14 REMARK 465 GLN B 15 REMARK 465 LEU B 16 REMARK 465 PRO B 17 REMARK 465 ILE B 18 REMARK 465 THR B 19 REMARK 465 GLU B 20 REMARK 465 ALA B 21 REMARK 465 GLN B 22 REMARK 465 SER B 23 REMARK 465 PHE B 24 REMARK 465 GLY B 25 REMARK 465 LEU B 26 REMARK 465 SER B 56 REMARK 465 ARG B 57 REMARK 465 SER B 58 REMARK 465 ALA B 59 REMARK 465 ASP B 60 REMARK 465 ALA B 61 REMARK 465 PRO B 62 REMARK 465 ALA B 63 REMARK 465 TYR B 64 REMARK 465 GLN B 65 REMARK 465 GLN B 66 REMARK 465 GLY B 67 REMARK 465 GLN B 68 REMARK 465 ASN B 69 REMARK 465 GLN B 70 REMARK 465 LEU B 71 REMARK 465 TYR B 72 REMARK 465 ASN B 73 REMARK 465 GLU B 74 REMARK 465 LEU B 75 REMARK 465 ASN B 76 REMARK 465 LEU B 77 REMARK 465 GLY B 78 REMARK 465 ARG B 79 REMARK 465 ARG B 80 REMARK 465 GLU B 81 REMARK 465 GLU B 82 REMARK 465 TYR B 83 REMARK 465 ASP B 84 REMARK 465 VAL B 85 REMARK 465 LEU B 86 REMARK 465 ASP B 87 REMARK 465 LYS B 88 REMARK 465 ARG B 89 REMARK 465 ARG B 90 REMARK 465 GLY B 91 REMARK 465 ARG B 92 REMARK 465 ASP B 93 REMARK 465 PRO B 94 REMARK 465 GLU B 95 REMARK 465 MET B 96 REMARK 465 GLY B 97 REMARK 465 GLY B 98 REMARK 465 LYS B 99 REMARK 465 PRO B 100 REMARK 465 GLN B 101 REMARK 465 ARG B 102 REMARK 465 ARG B 103 REMARK 465 LYS B 104 REMARK 465 ASN B 105 REMARK 465 PRO B 106 REMARK 465 GLN B 107 REMARK 465 GLU B 108 REMARK 465 GLY B 109 REMARK 465 LEU B 110 REMARK 465 TYR B 111 REMARK 465 ASN B 112 REMARK 465 GLU B 113 REMARK 465 LEU B 114 REMARK 465 GLN B 115 REMARK 465 LYS B 116 REMARK 465 ASP B 117 REMARK 465 LYS B 118 REMARK 465 MET B 119 REMARK 465 ALA B 120 REMARK 465 GLU B 121 REMARK 465 ALA B 122 REMARK 465 TYR B 123 REMARK 465 SER B 124 REMARK 465 GLU B 125 REMARK 465 ILE B 126 REMARK 465 GLY B 127 REMARK 465 MET B 128 REMARK 465 LYS B 129 REMARK 465 GLY B 130 REMARK 465 GLU B 131 REMARK 465 ARG B 132 REMARK 465 ARG B 133 REMARK 465 ARG B 134 REMARK 465 GLY B 135 REMARK 465 LYS B 136 REMARK 465 GLY B 137 REMARK 465 HIS B 138 REMARK 465 ASP B 139 REMARK 465 GLY B 140 REMARK 465 LEU B 141 REMARK 465 TYR B 142 REMARK 465 GLN B 143 REMARK 465 GLY B 144 REMARK 465 LEU B 145 REMARK 465 SER B 146 REMARK 465 THR B 147 REMARK 465 ALA B 148 REMARK 465 THR B 149 REMARK 465 LYS B 150 REMARK 465 ASP B 151 REMARK 465 THR B 152 REMARK 465 TYR B 153 REMARK 465 ASP B 154 REMARK 465 ALA B 155 REMARK 465 LEU B 156 REMARK 465 HIS B 157 REMARK 465 MET B 158 REMARK 465 GLN B 159 REMARK 465 ALA B 160 REMARK 465 LEU B 161 REMARK 465 PRO B 162 REMARK 465 PRO B 163 REMARK 465 ARG B 164 REMARK 465 SER B 165 REMARK 465 ALA B 166 REMARK 465 MET D 1 REMARK 465 GLU D 2 REMARK 465 HIS D 3 REMARK 465 SER D 4 REMARK 465 THR D 5 REMARK 465 PHE D 6 REMARK 465 LEU D 7 REMARK 465 SER D 8 REMARK 465 GLY D 9 REMARK 465 LEU D 10 REMARK 465 VAL D 11 REMARK 465 LEU D 12 REMARK 465 ALA D 13 REMARK 465 THR D 14 REMARK 465 LEU D 15 REMARK 465 LEU D 16 REMARK 465 SER D 17 REMARK 465 GLN D 18 REMARK 465 VAL D 19 REMARK 465 SER D 20 REMARK 465 PRO D 21 REMARK 465 GLY D 127 REMARK 465 HIS D 128 REMARK 465 GLU D 129 REMARK 465 THR D 130 REMARK 465 GLY D 131 REMARK 465 ARG D 132 REMARK 465 LEU D 133 REMARK 465 SER D 134 REMARK 465 GLY D 135 REMARK 465 ALA D 136 REMARK 465 ALA D 137 REMARK 465 ASP D 138 REMARK 465 THR D 139 REMARK 465 GLN D 140 REMARK 465 ALA D 141 REMARK 465 LEU D 142 REMARK 465 LEU D 143 REMARK 465 ARG D 144 REMARK 465 ASN D 145 REMARK 465 ASP D 146 REMARK 465 GLN D 147 REMARK 465 VAL D 148 REMARK 465 TYR D 149 REMARK 465 GLN D 150 REMARK 465 PRO D 151 REMARK 465 LEU D 152 REMARK 465 ARG D 153 REMARK 465 ASP D 154 REMARK 465 ARG D 155 REMARK 465 ASP D 156 REMARK 465 ASP D 157 REMARK 465 ALA D 158 REMARK 465 GLN D 159 REMARK 465 TYR D 160 REMARK 465 SER D 161 REMARK 465 HIS D 162 REMARK 465 LEU D 163 REMARK 465 GLY D 164 REMARK 465 GLY D 165 REMARK 465 ASN D 166 REMARK 465 TRP D 167 REMARK 465 ALA D 168 REMARK 465 ARG D 169 REMARK 465 ASN D 170 REMARK 465 LYS D 171 REMARK 465 MET E 1 REMARK 465 GLN E 2 REMARK 465 SER E 3 REMARK 465 GLY E 4 REMARK 465 THR E 5 REMARK 465 HIS E 6 REMARK 465 TRP E 7 REMARK 465 ARG E 8 REMARK 465 VAL E 9 REMARK 465 LEU E 10 REMARK 465 GLY E 11 REMARK 465 LEU E 12 REMARK 465 CYS E 13 REMARK 465 LEU E 14 REMARK 465 LEU E 15 REMARK 465 SER E 16 REMARK 465 VAL E 17 REMARK 465 GLY E 18 REMARK 465 VAL E 19 REMARK 465 TRP E 20 REMARK 465 GLY E 21 REMARK 465 GLN E 22 REMARK 465 ASP E 23 REMARK 465 GLY E 24 REMARK 465 ASN E 25 REMARK 465 GLU E 26 REMARK 465 GLU E 27 REMARK 465 MET E 28 REMARK 465 GLY E 29 REMARK 465 GLY E 30 REMARK 465 ILE E 31 REMARK 465 THR E 32 REMARK 465 ASN E 154 REMARK 465 ARG E 155 REMARK 465 LYS E 156 REMARK 465 ALA E 157 REMARK 465 LYS E 158 REMARK 465 ALA E 159 REMARK 465 LYS E 160 REMARK 465 PRO E 161 REMARK 465 VAL E 162 REMARK 465 THR E 163 REMARK 465 ARG E 164 REMARK 465 GLY E 165 REMARK 465 ALA E 166 REMARK 465 GLY E 167 REMARK 465 ALA E 168 REMARK 465 GLY E 169 REMARK 465 GLY E 170 REMARK 465 ARG E 171 REMARK 465 GLN E 172 REMARK 465 ARG E 173 REMARK 465 GLY E 174 REMARK 465 GLN E 175 REMARK 465 ASN E 176 REMARK 465 LYS E 177 REMARK 465 GLU E 178 REMARK 465 ARG E 179 REMARK 465 PRO E 180 REMARK 465 PRO E 181 REMARK 465 PRO E 182 REMARK 465 VAL E 183 REMARK 465 PRO E 184 REMARK 465 ASN E 185 REMARK 465 PRO E 186 REMARK 465 ASP E 187 REMARK 465 TYR E 188 REMARK 465 GLU E 189 REMARK 465 PRO E 190 REMARK 465 ILE E 191 REMARK 465 ARG E 192 REMARK 465 LYS E 193 REMARK 465 GLY E 194 REMARK 465 GLN E 195 REMARK 465 ARG E 196 REMARK 465 ASP E 197 REMARK 465 LEU E 198 REMARK 465 TYR E 199 REMARK 465 SER E 200 REMARK 465 GLY E 201 REMARK 465 LEU E 202 REMARK 465 ASN E 203 REMARK 465 GLN E 204 REMARK 465 ARG E 205 REMARK 465 ARG E 206 REMARK 465 ILE E 207 REMARK 465 MET F 1 REMARK 465 GLN F 2 REMARK 465 SER F 3 REMARK 465 GLY F 4 REMARK 465 THR F 5 REMARK 465 HIS F 6 REMARK 465 TRP F 7 REMARK 465 ARG F 8 REMARK 465 VAL F 9 REMARK 465 LEU F 10 REMARK 465 GLY F 11 REMARK 465 LEU F 12 REMARK 465 CYS F 13 REMARK 465 LEU F 14 REMARK 465 LEU F 15 REMARK 465 SER F 16 REMARK 465 VAL F 17 REMARK 465 GLY F 18 REMARK 465 VAL F 19 REMARK 465 TRP F 20 REMARK 465 GLY F 21 REMARK 465 GLN F 22 REMARK 465 ASP F 23 REMARK 465 GLY F 24 REMARK 465 ASN F 25 REMARK 465 GLU F 26 REMARK 465 GLU F 27 REMARK 465 MET F 28 REMARK 465 GLY F 29 REMARK 465 GLY F 30 REMARK 465 ILE F 31 REMARK 465 THR F 32 REMARK 465 GLU F 70 REMARK 465 ASP F 71 REMARK 465 ASP F 72 REMARK 465 LYS F 73 REMARK 465 ARG F 155 REMARK 465 LYS F 156 REMARK 465 ALA F 157 REMARK 465 LYS F 158 REMARK 465 ALA F 159 REMARK 465 LYS F 160 REMARK 465 PRO F 161 REMARK 465 VAL F 162 REMARK 465 THR F 163 REMARK 465 ARG F 164 REMARK 465 GLY F 165 REMARK 465 ALA F 166 REMARK 465 GLY F 167 REMARK 465 ALA F 168 REMARK 465 GLY F 169 REMARK 465 GLY F 170 REMARK 465 ARG F 171 REMARK 465 GLN F 172 REMARK 465 ARG F 173 REMARK 465 GLY F 174 REMARK 465 GLN F 175 REMARK 465 ASN F 176 REMARK 465 LYS F 177 REMARK 465 GLU F 178 REMARK 465 ARG F 179 REMARK 465 PRO F 180 REMARK 465 PRO F 181 REMARK 465 PRO F 182 REMARK 465 VAL F 183 REMARK 465 PRO F 184 REMARK 465 ASN F 185 REMARK 465 PRO F 186 REMARK 465 ASP F 187 REMARK 465 TYR F 188 REMARK 465 GLU F 189 REMARK 465 PRO F 190 REMARK 465 ILE F 191 REMARK 465 ARG F 192 REMARK 465 LYS F 193 REMARK 465 GLY F 194 REMARK 465 GLN F 195 REMARK 465 ARG F 196 REMARK 465 ASP F 197 REMARK 465 LEU F 198 REMARK 465 TYR F 199 REMARK 465 SER F 200 REMARK 465 GLY F 201 REMARK 465 LEU F 202 REMARK 465 ASN F 203 REMARK 465 GLN F 204 REMARK 465 ARG F 205 REMARK 465 ARG F 206 REMARK 465 ILE F 207 REMARK 465 MET G 1 REMARK 465 GLU G 2 REMARK 465 GLN G 3 REMARK 465 GLY G 4 REMARK 465 LYS G 5 REMARK 465 GLY G 6 REMARK 465 LEU G 7 REMARK 465 ALA G 8 REMARK 465 VAL G 9 REMARK 465 LEU G 10 REMARK 465 ILE G 11 REMARK 465 LEU G 12 REMARK 465 ALA G 13 REMARK 465 ILE G 14 REMARK 465 ILE G 15 REMARK 465 LEU G 16 REMARK 465 LEU G 17 REMARK 465 GLN G 18 REMARK 465 GLY G 19 REMARK 465 THR G 20 REMARK 465 LEU G 21 REMARK 465 ALA G 22 REMARK 465 GLN G 23 REMARK 465 SER G 24 REMARK 465 ILE G 25 REMARK 465 GLY G 141 REMARK 465 VAL G 142 REMARK 465 ARG G 143 REMARK 465 GLN G 144 REMARK 465 SER G 145 REMARK 465 ARG G 146 REMARK 465 ALA G 147 REMARK 465 SER G 148 REMARK 465 ASP G 149 REMARK 465 LYS G 150 REMARK 465 GLN G 151 REMARK 465 THR G 152 REMARK 465 LEU G 153 REMARK 465 LEU G 154 REMARK 465 PRO G 155 REMARK 465 ASN G 156 REMARK 465 ASP G 157 REMARK 465 GLN G 158 REMARK 465 LEU G 159 REMARK 465 TYR G 160 REMARK 465 GLN G 161 REMARK 465 PRO G 162 REMARK 465 LEU G 163 REMARK 465 LYS G 164 REMARK 465 ASP G 165 REMARK 465 ARG G 166 REMARK 465 GLU G 167 REMARK 465 ASP G 168 REMARK 465 ASP G 169 REMARK 465 GLN G 170 REMARK 465 TYR G 171 REMARK 465 SER G 172 REMARK 465 HIS G 173 REMARK 465 LEU G 174 REMARK 465 GLN G 175 REMARK 465 GLY G 176 REMARK 465 ASN G 177 REMARK 465 GLN G 178 REMARK 465 LEU G 179 REMARK 465 ARG G 180 REMARK 465 ARG G 181 REMARK 465 ASN G 182 REMARK 465 MET M -1 REMARK 465 GLN M 0 REMARK 465 ARG M 1 REMARK 465 ILE M 2 REMARK 465 SER M 3 REMARK 465 SER M 4 REMARK 465 LEU M 5 REMARK 465 ILE M 6 REMARK 465 HIS M 7 REMARK 465 LEU M 8 REMARK 465 SER M 9 REMARK 465 LEU M 10 REMARK 465 PHE M 11 REMARK 465 TRP M 12 REMARK 465 ALA M 13 REMARK 465 GLY M 14 REMARK 465 VAL M 15 REMARK 465 MET M 16 REMARK 465 SER M 17 REMARK 465 ALA M 18 REMARK 465 ILE M 19 REMARK 465 GLU M 20 REMARK 465 LEU M 21 REMARK 465 VAL M 22 REMARK 465 PRO M 23 REMARK 465 GLU M 24 REMARK 465 HIS M 25 REMARK 465 GLN M 26 REMARK 465 THR M 27 REMARK 465 VAL M 28 REMARK 465 PRO M 29 REMARK 465 VAL M 30 REMARK 465 SER M 31 REMARK 465 ILE M 32 REMARK 465 GLY M 33 REMARK 465 VAL M 34 REMARK 465 PRO M 35 REMARK 465 ALA M 36 REMARK 465 THR M 37 REMARK 465 LEU M 38 REMARK 465 ARG M 39 REMARK 465 CYS M 40 REMARK 465 SER M 41 REMARK 465 MET M 42 REMARK 465 LYS M 43 REMARK 465 GLY M 44 REMARK 465 GLU M 45 REMARK 465 ALA M 46 REMARK 465 ILE M 47 REMARK 465 GLY M 48 REMARK 465 ASN M 49 REMARK 465 TYR M 50 REMARK 465 TYR M 51 REMARK 465 ILE M 52 REMARK 465 ASN M 53 REMARK 465 TRP M 54 REMARK 465 TYR M 55 REMARK 465 ARG M 56 REMARK 465 LYS M 57 REMARK 465 THR M 58 REMARK 465 GLN M 59 REMARK 465 GLY M 60 REMARK 465 ASN M 61 REMARK 465 THR M 62 REMARK 465 MET M 63 REMARK 465 THR M 64 REMARK 465 PHE M 65 REMARK 465 ILE M 66 REMARK 465 TYR M 67 REMARK 465 ARG M 68 REMARK 465 GLU M 69 REMARK 465 LYS M 70 REMARK 465 ASP M 71 REMARK 465 ILE M 72 REMARK 465 TYR M 73 REMARK 465 GLY M 74 REMARK 465 PRO M 75 REMARK 465 GLY M 76 REMARK 465 PHE M 77 REMARK 465 LYS M 78 REMARK 465 ASP M 79 REMARK 465 ASN M 80 REMARK 465 PHE M 81 REMARK 465 GLN M 82 REMARK 465 GLY M 83 REMARK 465 ASP M 84 REMARK 465 ILE M 85 REMARK 465 ASP M 86 REMARK 465 ILE M 87 REMARK 465 ALA M 88 REMARK 465 LYS M 89 REMARK 465 ASN M 90 REMARK 465 LEU M 91 REMARK 465 ALA M 92 REMARK 465 VAL M 93 REMARK 465 LEU M 94 REMARK 465 LYS M 95 REMARK 465 ILE M 96 REMARK 465 LEU M 97 REMARK 465 ALA M 98 REMARK 465 PRO M 99 REMARK 465 SER M 100 REMARK 465 GLU M 101 REMARK 465 ARG M 102 REMARK 465 ASP M 103 REMARK 465 GLU M 104 REMARK 465 GLY M 105 REMARK 465 SER M 106 REMARK 465 TYR M 107 REMARK 465 TYR M 108 REMARK 465 CYS M 109 REMARK 465 ALA M 110 REMARK 465 CYS M 111 REMARK 465 ASP M 112 REMARK 465 THR M 113 REMARK 465 LEU M 114 REMARK 465 GLY M 115 REMARK 465 MET M 116 REMARK 465 GLY M 117 REMARK 465 GLY M 118 REMARK 465 GLU M 119 REMARK 465 TYR M 120 REMARK 465 THR M 121 REMARK 465 ASP M 122 REMARK 465 LYS M 123 REMARK 465 LEU M 124 REMARK 465 ILE M 125 REMARK 465 PHE M 126 REMARK 465 GLY M 127 REMARK 465 LYS M 128 REMARK 465 GLY M 129 REMARK 465 THR M 130 REMARK 465 ARG M 131 REMARK 465 VAL M 132 REMARK 465 THR M 133 REMARK 465 VAL M 134 REMARK 465 GLU M 135 REMARK 465 PRO M 136 REMARK 465 ARG M 137 REMARK 465 SER M 138 REMARK 465 GLN M 139 REMARK 465 PRO M 140 REMARK 465 HIS M 141 REMARK 465 THR M 142 REMARK 465 LYS M 143 REMARK 465 PRO M 144 REMARK 465 SER M 145 REMARK 465 VAL M 146 REMARK 465 PHE M 147 REMARK 465 VAL M 148 REMARK 465 MET M 149 REMARK 465 LYS M 150 REMARK 465 ASN M 151 REMARK 465 GLY M 152 REMARK 465 THR M 153 REMARK 465 ASN M 154 REMARK 465 VAL M 155 REMARK 465 ALA M 156 REMARK 465 CYS M 157 REMARK 465 LEU M 158 REMARK 465 VAL M 159 REMARK 465 LYS M 160 REMARK 465 GLU M 161 REMARK 465 PHE M 162 REMARK 465 TYR M 163 REMARK 465 PRO M 164 REMARK 465 LYS M 165 REMARK 465 ASP M 166 REMARK 465 ILE M 167 REMARK 465 ARG M 168 REMARK 465 ILE M 169 REMARK 465 ASN M 170 REMARK 465 LEU M 171 REMARK 465 VAL M 172 REMARK 465 SER M 173 REMARK 465 SER M 174 REMARK 465 LYS M 175 REMARK 465 LYS M 176 REMARK 465 ILE M 177 REMARK 465 THR M 178 REMARK 465 GLU M 179 REMARK 465 PHE M 180 REMARK 465 ASP M 181 REMARK 465 PRO M 182 REMARK 465 ALA M 183 REMARK 465 ILE M 184 REMARK 465 VAL M 185 REMARK 465 ILE M 186 REMARK 465 SER M 187 REMARK 465 PRO M 188 REMARK 465 SER M 189 REMARK 465 GLY M 190 REMARK 465 LYS M 191 REMARK 465 TYR M 192 REMARK 465 ASN M 193 REMARK 465 ALA M 194 REMARK 465 VAL M 195 REMARK 465 LYS M 196 REMARK 465 LEU M 197 REMARK 465 GLY M 198 REMARK 465 LYS M 199 REMARK 465 TYR M 200 REMARK 465 GLU M 201 REMARK 465 ASP M 202 REMARK 465 SER M 203 REMARK 465 ASN M 204 REMARK 465 SER M 205 REMARK 465 VAL M 206 REMARK 465 THR M 207 REMARK 465 CYS M 208 REMARK 465 SER M 209 REMARK 465 VAL M 210 REMARK 465 GLN M 211 REMARK 465 HIS M 212 REMARK 465 ASP M 213 REMARK 465 ASN M 214 REMARK 465 LYS M 215 REMARK 465 THR M 216 REMARK 465 VAL M 217 REMARK 465 HIS M 218 REMARK 465 SER M 219 REMARK 465 THR M 220 REMARK 465 ASP M 221 REMARK 465 PHE M 222 REMARK 465 GLU M 223 REMARK 465 VAL M 224 REMARK 465 LYS M 225 REMARK 465 THR M 226 REMARK 465 ASP M 227 REMARK 465 SER M 228 REMARK 465 THR M 229 REMARK 465 ASP M 230 REMARK 465 HIS M 231 REMARK 465 VAL M 232 REMARK 465 LYS M 233 REMARK 465 PRO M 234 REMARK 465 LYS M 235 REMARK 465 GLU M 236 REMARK 465 THR M 237 REMARK 465 GLU M 238 REMARK 465 ASN M 239 REMARK 465 THR M 240 REMARK 465 LYS M 241 REMARK 465 GLN M 242 REMARK 465 PRO M 243 REMARK 465 SER M 244 REMARK 465 LYS M 245 REMARK 465 SER M 246 REMARK 465 CYS M 247 REMARK 465 HIS M 248 REMARK 465 LYS M 249 REMARK 465 PRO M 250 REMARK 465 LYS M 251 REMARK 465 ALA M 252 REMARK 465 ILE M 253 REMARK 465 LEU M 290 REMARK 465 MET N -17 REMARK 465 LEU N -16 REMARK 465 SER N -15 REMARK 465 LEU N -14 REMARK 465 LEU N -13 REMARK 465 HIS N -12 REMARK 465 THR N -11 REMARK 465 SER N -10 REMARK 465 THR N -9 REMARK 465 LEU N -8 REMARK 465 ALA N -7 REMARK 465 VAL N -6 REMARK 465 LEU N -5 REMARK 465 GLY N -4 REMARK 465 ALA N -3 REMARK 465 LEU N -2 REMARK 465 CYS N -1 REMARK 465 VAL N 0 REMARK 465 TYR N 1 REMARK 465 GLY N 2 REMARK 465 ALA N 3 REMARK 465 GLY N 4 REMARK 465 HIS N 5 REMARK 465 LEU N 6 REMARK 465 GLU N 7 REMARK 465 GLN N 8 REMARK 465 PRO N 9 REMARK 465 GLN N 10 REMARK 465 ILE N 11 REMARK 465 SER N 12 REMARK 465 SER N 13 REMARK 465 THR N 14 REMARK 465 LYS N 15 REMARK 465 THR N 16 REMARK 465 LEU N 17 REMARK 465 SER N 18 REMARK 465 LYS N 19 REMARK 465 THR N 20 REMARK 465 ALA N 21 REMARK 465 ARG N 22 REMARK 465 LEU N 23 REMARK 465 GLU N 24 REMARK 465 CYS N 25 REMARK 465 VAL N 26 REMARK 465 VAL N 27 REMARK 465 SER N 28 REMARK 465 GLY N 29 REMARK 465 ILE N 30 REMARK 465 THR N 31 REMARK 465 ILE N 32 REMARK 465 SER N 33 REMARK 465 ALA N 34 REMARK 465 THR N 35 REMARK 465 SER N 36 REMARK 465 VAL N 37 REMARK 465 TYR N 38 REMARK 465 TRP N 39 REMARK 465 TYR N 40 REMARK 465 ARG N 41 REMARK 465 GLU N 42 REMARK 465 ARG N 43 REMARK 465 PRO N 44 REMARK 465 GLY N 45 REMARK 465 GLU N 46 REMARK 465 VAL N 47 REMARK 465 ILE N 48 REMARK 465 GLN N 49 REMARK 465 PHE N 50 REMARK 465 LEU N 51 REMARK 465 VAL N 52 REMARK 465 SER N 53 REMARK 465 ILE N 54 REMARK 465 SER N 55 REMARK 465 TYR N 56 REMARK 465 ASP N 57 REMARK 465 GLY N 58 REMARK 465 THR N 59 REMARK 465 VAL N 60 REMARK 465 ARG N 61 REMARK 465 LYS N 62 REMARK 465 GLU N 63 REMARK 465 SER N 64 REMARK 465 GLY N 65 REMARK 465 ILE N 66 REMARK 465 PRO N 67 REMARK 465 SER N 68 REMARK 465 GLY N 69 REMARK 465 LYS N 70 REMARK 465 PHE N 71 REMARK 465 GLU N 72 REMARK 465 VAL N 73 REMARK 465 ASP N 74 REMARK 465 ARG N 75 REMARK 465 ILE N 76 REMARK 465 PRO N 77 REMARK 465 GLU N 78 REMARK 465 THR N 79 REMARK 465 SER N 80 REMARK 465 THR N 81 REMARK 465 SER N 82 REMARK 465 THR N 83 REMARK 465 LEU N 84 REMARK 465 THR N 85 REMARK 465 ILE N 86 REMARK 465 HIS N 87 REMARK 465 ASN N 88 REMARK 465 VAL N 89 REMARK 465 GLU N 90 REMARK 465 LYS N 91 REMARK 465 GLN N 92 REMARK 465 ASP N 93 REMARK 465 ILE N 94 REMARK 465 ALA N 95 REMARK 465 THR N 96 REMARK 465 TYR N 97 REMARK 465 TYR N 98 REMARK 465 CYS N 99 REMARK 465 ALA N 100 REMARK 465 LEU N 101 REMARK 465 TRP N 102 REMARK 465 GLU N 103 REMARK 465 ALA N 104 REMARK 465 GLN N 105 REMARK 465 GLN N 106 REMARK 465 GLU N 107 REMARK 465 LEU N 108 REMARK 465 GLY N 109 REMARK 465 LYS N 110 REMARK 465 LYS N 111 REMARK 465 ILE N 112 REMARK 465 LYS N 113 REMARK 465 VAL N 114 REMARK 465 PHE N 115 REMARK 465 GLY N 116 REMARK 465 PRO N 117 REMARK 465 GLY N 118 REMARK 465 THR N 119 REMARK 465 LYS N 120 REMARK 465 LEU N 121 REMARK 465 ILE N 122 REMARK 465 ILE N 123 REMARK 465 THR N 124 REMARK 465 ASP N 125 REMARK 465 LYS N 126 REMARK 465 GLN N 127 REMARK 465 LEU N 128 REMARK 465 ASP N 129 REMARK 465 ALA N 130 REMARK 465 ASP N 131 REMARK 465 VAL N 132 REMARK 465 SER N 133 REMARK 465 PRO N 134 REMARK 465 LYS N 135 REMARK 465 PRO N 136 REMARK 465 THR N 137 REMARK 465 ILE N 138 REMARK 465 PHE N 139 REMARK 465 LEU N 140 REMARK 465 PRO N 141 REMARK 465 SER N 142 REMARK 465 ILE N 143 REMARK 465 ALA N 144 REMARK 465 GLU N 145 REMARK 465 THR N 146 REMARK 465 LYS N 147 REMARK 465 LEU N 148 REMARK 465 GLN N 149 REMARK 465 LYS N 150 REMARK 465 ALA N 151 REMARK 465 GLY N 152 REMARK 465 THR N 153 REMARK 465 TYR N 154 REMARK 465 LEU N 155 REMARK 465 CYS N 156 REMARK 465 LEU N 157 REMARK 465 LEU N 158 REMARK 465 GLU N 159 REMARK 465 LYS N 160 REMARK 465 PHE N 161 REMARK 465 PHE N 162 REMARK 465 PRO N 163 REMARK 465 ASP N 164 REMARK 465 VAL N 165 REMARK 465 ILE N 166 REMARK 465 LYS N 167 REMARK 465 ILE N 168 REMARK 465 HIS N 169 REMARK 465 TRP N 170 REMARK 465 GLU N 171 REMARK 465 GLU N 172 REMARK 465 LYS N 173 REMARK 465 LYS N 174 REMARK 465 SER N 175 REMARK 465 ASN N 176 REMARK 465 THR N 177 REMARK 465 ILE N 178 REMARK 465 LEU N 179 REMARK 465 GLY N 180 REMARK 465 SER N 181 REMARK 465 GLN N 182 REMARK 465 GLU N 183 REMARK 465 GLY N 184 REMARK 465 ASN N 185 REMARK 465 THR N 186 REMARK 465 MET N 187 REMARK 465 LYS N 188 REMARK 465 THR N 189 REMARK 465 ASN N 190 REMARK 465 ASP N 191 REMARK 465 THR N 192 REMARK 465 TYR N 193 REMARK 465 MET N 194 REMARK 465 LYS N 195 REMARK 465 PHE N 196 REMARK 465 SER N 197 REMARK 465 TRP N 198 REMARK 465 LEU N 199 REMARK 465 THR N 200 REMARK 465 VAL N 201 REMARK 465 PRO N 202 REMARK 465 GLU N 203 REMARK 465 LYS N 204 REMARK 465 SER N 205 REMARK 465 LEU N 206 REMARK 465 ASP N 207 REMARK 465 LYS N 208 REMARK 465 GLU N 209 REMARK 465 HIS N 210 REMARK 465 ARG N 211 REMARK 465 CYS N 212 REMARK 465 ILE N 213 REMARK 465 VAL N 214 REMARK 465 ARG N 215 REMARK 465 HIS N 216 REMARK 465 GLU N 217 REMARK 465 ASN N 218 REMARK 465 ASN N 219 REMARK 465 LYS N 220 REMARK 465 ASN N 221 REMARK 465 GLY N 222 REMARK 465 VAL N 223 REMARK 465 ASP N 224 REMARK 465 GLN N 225 REMARK 465 GLU N 226 REMARK 465 ILE N 227 REMARK 465 ILE N 228 REMARK 465 PHE N 229 REMARK 465 PRO N 230 REMARK 465 PRO N 231 REMARK 465 ILE N 232 REMARK 465 LYS N 233 REMARK 465 THR N 234 REMARK 465 ASP N 235 REMARK 465 VAL N 236 REMARK 465 ILE N 237 REMARK 465 THR N 238 REMARK 465 MET N 239 REMARK 465 ASP N 240 REMARK 465 PRO N 241 REMARK 465 LYS N 242 REMARK 465 ASP N 243 REMARK 465 ASN N 244 REMARK 465 CYS N 245 REMARK 465 SER N 246 REMARK 465 LYS N 247 REMARK 465 ASP N 248 REMARK 465 ALA N 249 REMARK 465 ASN N 250 REMARK 465 ALA N 289 REMARK 465 PHE N 290 REMARK 465 CYS N 291 REMARK 465 CYS N 292 REMARK 465 ASN N 293 REMARK 465 GLY N 294 REMARK 465 GLU N 295 REMARK 465 LYS N 296 REMARK 465 SER N 297 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ARG O 108 CG CD NE CZ NH1 NH2 REMARK 470 SER O 154 OG REMARK 470 GLU O 155 CG CD OE1 OE2 REMARK 470 GLN O 157 CG CD OE1 NE2 REMARK 470 ASN O 158 CG OD1 ND2 REMARK 470 LYS O 170 CG CD CE NZ REMARK 470 ASN O 185 CG OD1 ND2 REMARK 470 GLU O 186 CG CD OE1 OE2 REMARK 470 TYR O 187 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 GLU O 188 CG CD OE1 OE2 REMARK 470 ARG O 189 CG CD NE CZ NH1 NH2 REMARK 470 ARG Q 108 CG CD NE CZ NH1 NH2 REMARK 470 SER Q 154 OG REMARK 470 GLU Q 155 CG CD OE1 OE2 REMARK 470 GLN Q 157 CG CD OE1 NE2 REMARK 470 ASN Q 158 CG OD1 ND2 REMARK 470 LYS Q 170 CG CD CE NZ REMARK 470 ASN Q 185 CG OD1 ND2 REMARK 470 GLU Q 186 CG CD OE1 OE2 REMARK 470 TYR Q 187 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 GLU Q 188 CG CD OE1 OE2 REMARK 470 ARG Q 189 CG CD NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 O GLU e 89 OG SER e 93 2.00 REMARK 500 O GLU E 89 OG SER E 93 2.01 REMARK 500 O THR d 47 OH TYR d 71 2.14 REMARK 500 O THR D 47 OH TYR D 71 2.15 REMARK 500 OH TYR P 102 O GLY e 67 2.16 REMARK 500 OH TYR R 102 O GLY E 67 2.16 REMARK 500 OG1 THR m 256 ND2 ASN m 260 2.18 REMARK 500 OG1 THR M 256 ND2 ASN M 260 2.18 REMARK 500 O ILE Q 106 OH TYR Q 141 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 LEU g 119 CA - CB - CG ANGL. DEV. = 13.9 DEGREES REMARK 500 LEU A 34 CA - CB - CG ANGL. DEV. = 14.2 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA P 92 -169.04 -161.81 REMARK 500 SER P 105 28.66 -141.47 REMARK 500 ASP P 182 49.83 -77.95 REMARK 500 SER P 187 79.50 -101.07 REMARK 500 LEU O 47 -62.94 -90.38 REMARK 500 THR O 51 -16.21 72.28 REMARK 500 SER O 52 -31.90 -136.73 REMARK 500 ASP a 28 159.18 67.72 REMARK 500 PHE a 55 -130.08 57.29 REMARK 500 GLU e 79 -124.59 53.30 REMARK 500 GLN e 92 32.69 -99.85 REMARK 500 ASP e 107 58.93 -91.11 REMARK 500 ASP g 68 -0.37 67.11 REMARK 500 ASP g 80 70.12 57.92 REMARK 500 LEU g 110 51.82 -93.69 REMARK 500 ALA R 92 -169.03 -161.81 REMARK 500 SER R 105 28.59 -141.36 REMARK 500 ASP R 182 49.79 -78.01 REMARK 500 SER R 187 79.45 -101.05 REMARK 500 LEU Q 47 -63.01 -90.42 REMARK 500 THR Q 51 -16.20 72.33 REMARK 500 SER Q 52 -31.92 -136.73 REMARK 500 PRO Q 142 -159.54 -87.28 REMARK 500 ASP Q 171 -15.74 -140.56 REMARK 500 ASP A 28 159.25 67.82 REMARK 500 PHE A 55 -130.13 57.31 REMARK 500 GLU E 79 -124.45 53.28 REMARK 500 GLN E 92 32.71 -99.85 REMARK 500 ASP E 107 58.92 -91.05 REMARK 500 ASP G 68 -0.37 67.11 REMARK 500 ASP G 80 70.11 57.95 REMARK 500 LEU G 110 51.98 -93.91 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-61884 RELATED DB: EMDB REMARK 900 DELTA EPSILON/DELTA EPSILON FAB-TCR TETRAMER DBREF 9JY1 P 1 222 PDB 9JY1 9JY1 1 222 DBREF 9JY1 O 1 213 PDB 9JY1 9JY1 1 213 DBREF 9JY1 a 1 164 UNP P20963 CD3Z_HUMAN 1 164 DBREF 9JY1 b 1 164 UNP P20963 CD3Z_HUMAN 1 164 DBREF 9JY1 d 1 171 UNP P04234 CD3D_HUMAN 1 171 DBREF 9JY1 e 1 207 UNP P07766 CD3E_HUMAN 1 207 DBREF 9JY1 f 1 207 UNP P07766 CD3E_HUMAN 1 207 DBREF 9JY1 g 1 182 UNP P09693 CD3G_HUMAN 1 182 DBREF 9JY1 m -1 290 UNP B7Z8B9 B7Z8B9_HUMAN 1 293 DBREF 9JY1 n -17 103 UNP Q99603 TRGV9_HUMAN 1 121 DBREF 9JY1 n 125 297 UNP P0CF51 TRGC1_HUMAN 1 173 DBREF 9JY1 R 1 222 PDB 9JY1 9JY1 1 222 DBREF 9JY1 Q 1 213 PDB 9JY1 9JY1 1 213 DBREF 9JY1 A 1 164 UNP P20963 CD3Z_HUMAN 1 164 DBREF 9JY1 B 1 164 UNP P20963 CD3Z_HUMAN 1 164 DBREF 9JY1 D 1 171 UNP P04234 CD3D_HUMAN 1 171 DBREF 9JY1 E 1 207 UNP P07766 CD3E_HUMAN 1 207 DBREF 9JY1 F 1 207 UNP P07766 CD3E_HUMAN 1 207 DBREF 9JY1 G 1 182 UNP P09693 CD3G_HUMAN 1 182 DBREF 9JY1 M -1 290 UNP B7Z8B9 B7Z8B9_HUMAN 1 293 DBREF 9JY1 N -17 103 UNP Q99603 TRGV9_HUMAN 1 121 DBREF 9JY1 N 125 297 UNP P0CF51 TRGC1_HUMAN 1 173 SEQADV 9JY1 SER a 165 UNP P20963 EXPRESSION TAG SEQADV 9JY1 ALA a 166 UNP P20963 EXPRESSION TAG SEQADV 9JY1 SER b 165 UNP P20963 EXPRESSION TAG SEQADV 9JY1 ALA b 166 UNP P20963 EXPRESSION TAG SEQADV 9JY1 LEU m 114 UNP B7Z8B9 VAL 116 CONFLICT SEQADV 9JY1 GLY m 115 UNP B7Z8B9 TYR 117 CONFLICT SEQADV 9JY1 MET m 116 UNP B7Z8B9 TRP 118 CONFLICT SEQADV 9JY1 m UNP B7Z8B9 ILE 120 DELETION SEQADV 9JY1 GLY m 118 UNP B7Z8B9 SER 121 CONFLICT SEQADV 9JY1 GLU m 119 UNP B7Z8B9 ARG 122 CONFLICT SEQADV 9JY1 ALA n 104 UNP Q99603 LINKER SEQADV 9JY1 GLN n 105 UNP Q99603 LINKER SEQADV 9JY1 GLN n 106 UNP Q99603 LINKER SEQADV 9JY1 GLU n 107 UNP Q99603 LINKER SEQADV 9JY1 LEU n 108 UNP Q99603 LINKER SEQADV 9JY1 GLY n 109 UNP Q99603 LINKER SEQADV 9JY1 LYS n 110 UNP Q99603 LINKER SEQADV 9JY1 LYS n 111 UNP Q99603 LINKER SEQADV 9JY1 ILE n 112 UNP Q99603 LINKER SEQADV 9JY1 LYS n 113 UNP Q99603 LINKER SEQADV 9JY1 VAL n 114 UNP Q99603 LINKER SEQADV 9JY1 PHE n 115 UNP Q99603 LINKER SEQADV 9JY1 GLY n 116 UNP Q99603 LINKER SEQADV 9JY1 PRO n 117 UNP Q99603 LINKER SEQADV 9JY1 GLY n 118 UNP Q99603 LINKER SEQADV 9JY1 THR n 119 UNP Q99603 LINKER SEQADV 9JY1 LYS n 120 UNP Q99603 LINKER SEQADV 9JY1 LEU n 121 UNP Q99603 LINKER SEQADV 9JY1 ILE n 122 UNP Q99603 LINKER SEQADV 9JY1 ILE n 123 UNP Q99603 LINKER SEQADV 9JY1 THR n 124 UNP Q99603 LINKER SEQADV 9JY1 GLU n 171 UNP P0CF51 GLN 47 CONFLICT SEQADV 9JY1 SER A 165 UNP P20963 EXPRESSION TAG SEQADV 9JY1 ALA A 166 UNP P20963 EXPRESSION TAG SEQADV 9JY1 SER B 165 UNP P20963 EXPRESSION TAG SEQADV 9JY1 ALA B 166 UNP P20963 EXPRESSION TAG SEQADV 9JY1 LEU M 114 UNP B7Z8B9 VAL 116 CONFLICT SEQADV 9JY1 GLY M 115 UNP B7Z8B9 TYR 117 CONFLICT SEQADV 9JY1 MET M 116 UNP B7Z8B9 TRP 118 CONFLICT SEQADV 9JY1 M UNP B7Z8B9 ILE 120 DELETION SEQADV 9JY1 GLY M 118 UNP B7Z8B9 SER 121 CONFLICT SEQADV 9JY1 GLU M 119 UNP B7Z8B9 ARG 122 CONFLICT SEQADV 9JY1 ALA N 104 UNP Q99603 LINKER SEQADV 9JY1 GLN N 105 UNP Q99603 LINKER SEQADV 9JY1 GLN N 106 UNP Q99603 LINKER SEQADV 9JY1 GLU N 107 UNP Q99603 LINKER SEQADV 9JY1 LEU N 108 UNP Q99603 LINKER SEQADV 9JY1 GLY N 109 UNP Q99603 LINKER SEQADV 9JY1 LYS N 110 UNP Q99603 LINKER SEQADV 9JY1 LYS N 111 UNP Q99603 LINKER SEQADV 9JY1 ILE N 112 UNP Q99603 LINKER SEQADV 9JY1 LYS N 113 UNP Q99603 LINKER SEQADV 9JY1 VAL N 114 UNP Q99603 LINKER SEQADV 9JY1 PHE N 115 UNP Q99603 LINKER SEQADV 9JY1 GLY N 116 UNP Q99603 LINKER SEQADV 9JY1 PRO N 117 UNP Q99603 LINKER SEQADV 9JY1 GLY N 118 UNP Q99603 LINKER SEQADV 9JY1 THR N 119 UNP Q99603 LINKER SEQADV 9JY1 LYS N 120 UNP Q99603 LINKER SEQADV 9JY1 LEU N 121 UNP Q99603 LINKER SEQADV 9JY1 ILE N 122 UNP Q99603 LINKER SEQADV 9JY1 ILE N 123 UNP Q99603 LINKER SEQADV 9JY1 THR N 124 UNP Q99603 LINKER SEQADV 9JY1 GLU N 171 UNP P0CF51 GLN 47 CONFLICT SEQRES 1 P 222 GLU VAL GLN LEU GLN GLN SER GLY PRO GLU LEU VAL LYS SEQRES 2 P 222 PRO GLY ALA SER MET LYS ILE SER CYS LYS ALA SER GLY SEQRES 3 P 222 TYR SER PHE THR GLY TYR THR MET ASN TRP VAL LYS GLN SEQRES 4 P 222 SER HIS GLY LYS ASN LEU GLU TRP MET GLY LEU ILE ASN SEQRES 5 P 222 PRO TYR LYS GLY VAL SER THR TYR ASN GLN LYS PHE LYS SEQRES 6 P 222 ASP LYS ALA THR LEU THR VAL ASP LYS SER SER SER THR SEQRES 7 P 222 ALA TYR MET GLU LEU LEU SER LEU THR SER GLU ASP SER SEQRES 8 P 222 ALA VAL TYR TYR CYS ALA ARG SER GLY TYR TYR GLY ASP SEQRES 9 P 222 SER ASP TRP TYR PHE ASP VAL TRP GLY GLN GLY THR THR SEQRES 10 P 222 LEU THR VAL PHE SER ALA LYS THR THR PRO PRO SER VAL SEQRES 11 P 222 TYR PRO LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER SEQRES 12 P 222 MET VAL THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO SEQRES 13 P 222 GLU PRO VAL THR VAL THR TRP ASN SER GLY SER LEU SER SEQRES 14 P 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU LYS SER ASP SEQRES 15 P 222 LEU TYR THR LEU SER SER SER VAL THR VAL PRO SER SER SEQRES 16 P 222 PRO ARG PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS SEQRES 17 P 222 PRO ALA SER SER THR THR VAL ASP LYS LYS ILE VAL PRO SEQRES 18 P 222 ARG SEQRES 1 O 212 ASP ILE GLN MET THR GLN THR THR SER SER LEU SER ALA SEQRES 2 O 212 SER LEU GLY ASP ARG VAL THR ILE SER CYS ARG ALA SER SEQRES 3 O 212 GLN ASP ILE ARG ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 O 212 PRO ASP GLY THR VAL LYS LEU LEU ILE TYR TYR THR SER SEQRES 5 O 212 ARG LEU HIS SER GLY VAL PRO SER LYS PHE SER GLY SER SEQRES 6 O 212 GLY SER GLY THR ASP TYR SER LEU THR ILE SER ASN LEU SEQRES 7 O 212 GLU GLN GLU ASP ILE ALA THR TYR PHE CYS GLN GLN GLY SEQRES 8 O 212 ASN THR LEU PRO TRP THR PHE ALA GLY GLY THR LYS LEU SEQRES 9 O 212 GLU ILE LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 O 212 PHE PRO PRO ALA SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 O 212 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS SER SEQRES 12 O 212 ILE ASN SER LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 O 212 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 O 212 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 O 212 LYS ASN GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 O 212 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 O 212 PHE ASN ARG SER SEQRES 1 a 166 MET LYS TRP LYS ALA LEU PHE THR ALA ALA ILE LEU GLN SEQRES 2 a 166 ALA GLN LEU PRO ILE THR GLU ALA GLN SER PHE GLY LEU SEQRES 3 a 166 LEU ASP PRO LYS LEU CYS TYR LEU LEU ASP GLY ILE LEU SEQRES 4 a 166 PHE ILE TYR GLY VAL ILE LEU THR ALA LEU PHE LEU ARG SEQRES 5 a 166 VAL LYS PHE SER ARG SER ALA ASP ALA PRO ALA TYR GLN SEQRES 6 a 166 GLN GLY GLN ASN GLN LEU TYR ASN GLU LEU ASN LEU GLY SEQRES 7 a 166 ARG ARG GLU GLU TYR ASP VAL LEU ASP LYS ARG ARG GLY SEQRES 8 a 166 ARG ASP PRO GLU MET GLY GLY LYS PRO GLN ARG ARG LYS SEQRES 9 a 166 ASN PRO GLN GLU GLY LEU TYR ASN GLU LEU GLN LYS ASP SEQRES 10 a 166 LYS MET ALA GLU ALA TYR SER GLU ILE GLY MET LYS GLY SEQRES 11 a 166 GLU ARG ARG ARG GLY LYS GLY HIS ASP GLY LEU TYR GLN SEQRES 12 a 166 GLY LEU SER THR ALA THR LYS ASP THR TYR ASP ALA LEU SEQRES 13 a 166 HIS MET GLN ALA LEU PRO PRO ARG SER ALA SEQRES 1 b 166 MET LYS TRP LYS ALA LEU PHE THR ALA ALA ILE LEU GLN SEQRES 2 b 166 ALA GLN LEU PRO ILE THR GLU ALA GLN SER PHE GLY LEU SEQRES 3 b 166 LEU ASP PRO LYS LEU CYS TYR LEU LEU ASP GLY ILE LEU SEQRES 4 b 166 PHE ILE TYR GLY VAL ILE LEU THR ALA LEU PHE LEU ARG SEQRES 5 b 166 VAL LYS PHE SER ARG SER ALA ASP ALA PRO ALA TYR GLN SEQRES 6 b 166 GLN GLY GLN ASN GLN LEU TYR ASN GLU LEU ASN LEU GLY SEQRES 7 b 166 ARG ARG GLU GLU TYR ASP VAL LEU ASP LYS ARG ARG GLY SEQRES 8 b 166 ARG ASP PRO GLU MET GLY GLY LYS PRO GLN ARG ARG LYS SEQRES 9 b 166 ASN PRO GLN GLU GLY LEU TYR ASN GLU LEU GLN LYS ASP SEQRES 10 b 166 LYS MET ALA GLU ALA TYR SER GLU ILE GLY MET LYS GLY SEQRES 11 b 166 GLU ARG ARG ARG GLY LYS GLY HIS ASP GLY LEU TYR GLN SEQRES 12 b 166 GLY LEU SER THR ALA THR LYS ASP THR TYR ASP ALA LEU SEQRES 13 b 166 HIS MET GLN ALA LEU PRO PRO ARG SER ALA SEQRES 1 d 171 MET GLU HIS SER THR PHE LEU SER GLY LEU VAL LEU ALA SEQRES 2 d 171 THR LEU LEU SER GLN VAL SER PRO PHE LYS ILE PRO ILE SEQRES 3 d 171 GLU GLU LEU GLU ASP ARG VAL PHE VAL ASN CYS ASN THR SEQRES 4 d 171 SER ILE THR TRP VAL GLU GLY THR VAL GLY THR LEU LEU SEQRES 5 d 171 SER ASP ILE THR ARG LEU ASP LEU GLY LYS ARG ILE LEU SEQRES 6 d 171 ASP PRO ARG GLY ILE TYR ARG CYS ASN GLY THR ASP ILE SEQRES 7 d 171 TYR LYS ASP LYS GLU SER THR VAL GLN VAL HIS TYR ARG SEQRES 8 d 171 MET CYS GLN SER CYS VAL GLU LEU ASP PRO ALA THR VAL SEQRES 9 d 171 ALA GLY ILE ILE VAL THR ASP VAL ILE ALA THR LEU LEU SEQRES 10 d 171 LEU ALA LEU GLY VAL PHE CYS PHE ALA GLY HIS GLU THR SEQRES 11 d 171 GLY ARG LEU SER GLY ALA ALA ASP THR GLN ALA LEU LEU SEQRES 12 d 171 ARG ASN ASP GLN VAL TYR GLN PRO LEU ARG ASP ARG ASP SEQRES 13 d 171 ASP ALA GLN TYR SER HIS LEU GLY GLY ASN TRP ALA ARG SEQRES 14 d 171 ASN LYS SEQRES 1 e 207 MET GLN SER GLY THR HIS TRP ARG VAL LEU GLY LEU CYS SEQRES 2 e 207 LEU LEU SER VAL GLY VAL TRP GLY GLN ASP GLY ASN GLU SEQRES 3 e 207 GLU MET GLY GLY ILE THR GLN THR PRO TYR LYS VAL SER SEQRES 4 e 207 ILE SER GLY THR THR VAL ILE LEU THR CYS PRO GLN TYR SEQRES 5 e 207 PRO GLY SER GLU ILE LEU TRP GLN HIS ASN ASP LYS ASN SEQRES 6 e 207 ILE GLY GLY ASP GLU ASP ASP LYS ASN ILE GLY SER ASP SEQRES 7 e 207 GLU ASP HIS LEU SER LEU LYS GLU PHE SER GLU LEU GLU SEQRES 8 e 207 GLN SER GLY TYR TYR VAL CYS TYR PRO ARG GLY SER LYS SEQRES 9 e 207 PRO GLU ASP ALA ASN PHE TYR LEU TYR LEU ARG ALA ARG SEQRES 10 e 207 VAL CYS GLU ASN CYS MET GLU MET ASP VAL MET SER VAL SEQRES 11 e 207 ALA THR ILE VAL ILE VAL ASP ILE CYS ILE THR GLY GLY SEQRES 12 e 207 LEU LEU LEU LEU VAL TYR TYR TRP SER LYS ASN ARG LYS SEQRES 13 e 207 ALA LYS ALA LYS PRO VAL THR ARG GLY ALA GLY ALA GLY SEQRES 14 e 207 GLY ARG GLN ARG GLY GLN ASN LYS GLU ARG PRO PRO PRO SEQRES 15 e 207 VAL PRO ASN PRO ASP TYR GLU PRO ILE ARG LYS GLY GLN SEQRES 16 e 207 ARG ASP LEU TYR SER GLY LEU ASN GLN ARG ARG ILE SEQRES 1 f 207 MET GLN SER GLY THR HIS TRP ARG VAL LEU GLY LEU CYS SEQRES 2 f 207 LEU LEU SER VAL GLY VAL TRP GLY GLN ASP GLY ASN GLU SEQRES 3 f 207 GLU MET GLY GLY ILE THR GLN THR PRO TYR LYS VAL SER SEQRES 4 f 207 ILE SER GLY THR THR VAL ILE LEU THR CYS PRO GLN TYR SEQRES 5 f 207 PRO GLY SER GLU ILE LEU TRP GLN HIS ASN ASP LYS ASN SEQRES 6 f 207 ILE GLY GLY ASP GLU ASP ASP LYS ASN ILE GLY SER ASP SEQRES 7 f 207 GLU ASP HIS LEU SER LEU LYS GLU PHE SER GLU LEU GLU SEQRES 8 f 207 GLN SER GLY TYR TYR VAL CYS TYR PRO ARG GLY SER LYS SEQRES 9 f 207 PRO GLU ASP ALA ASN PHE TYR LEU TYR LEU ARG ALA ARG SEQRES 10 f 207 VAL CYS GLU ASN CYS MET GLU MET ASP VAL MET SER VAL SEQRES 11 f 207 ALA THR ILE VAL ILE VAL ASP ILE CYS ILE THR GLY GLY SEQRES 12 f 207 LEU LEU LEU LEU VAL TYR TYR TRP SER LYS ASN ARG LYS SEQRES 13 f 207 ALA LYS ALA LYS PRO VAL THR ARG GLY ALA GLY ALA GLY SEQRES 14 f 207 GLY ARG GLN ARG GLY GLN ASN LYS GLU ARG PRO PRO PRO SEQRES 15 f 207 VAL PRO ASN PRO ASP TYR GLU PRO ILE ARG LYS GLY GLN SEQRES 16 f 207 ARG ASP LEU TYR SER GLY LEU ASN GLN ARG ARG ILE SEQRES 1 g 182 MET GLU GLN GLY LYS GLY LEU ALA VAL LEU ILE LEU ALA SEQRES 2 g 182 ILE ILE LEU LEU GLN GLY THR LEU ALA GLN SER ILE LYS SEQRES 3 g 182 GLY ASN HIS LEU VAL LYS VAL TYR ASP TYR GLN GLU ASP SEQRES 4 g 182 GLY SER VAL LEU LEU THR CYS ASP ALA GLU ALA LYS ASN SEQRES 5 g 182 ILE THR TRP PHE LYS ASP GLY LYS MET ILE GLY PHE LEU SEQRES 6 g 182 THR GLU ASP LYS LYS LYS TRP ASN LEU GLY SER ASN ALA SEQRES 7 g 182 LYS ASP PRO ARG GLY MET TYR GLN CYS LYS GLY SER GLN SEQRES 8 g 182 ASN LYS SER LYS PRO LEU GLN VAL TYR TYR ARG MET CYS SEQRES 9 g 182 GLN ASN CYS ILE GLU LEU ASN ALA ALA THR ILE SER GLY SEQRES 10 g 182 PHE LEU PHE ALA GLU ILE VAL SER ILE PHE VAL LEU ALA SEQRES 11 g 182 VAL GLY VAL TYR PHE ILE ALA GLY GLN ASP GLY VAL ARG SEQRES 12 g 182 GLN SER ARG ALA SER ASP LYS GLN THR LEU LEU PRO ASN SEQRES 13 g 182 ASP GLN LEU TYR GLN PRO LEU LYS ASP ARG GLU ASP ASP SEQRES 14 g 182 GLN TYR SER HIS LEU GLN GLY ASN GLN LEU ARG ARG ASN SEQRES 1 m 292 MET GLN ARG ILE SER SER LEU ILE HIS LEU SER LEU PHE SEQRES 2 m 292 TRP ALA GLY VAL MET SER ALA ILE GLU LEU VAL PRO GLU SEQRES 3 m 292 HIS GLN THR VAL PRO VAL SER ILE GLY VAL PRO ALA THR SEQRES 4 m 292 LEU ARG CYS SER MET LYS GLY GLU ALA ILE GLY ASN TYR SEQRES 5 m 292 TYR ILE ASN TRP TYR ARG LYS THR GLN GLY ASN THR MET SEQRES 6 m 292 THR PHE ILE TYR ARG GLU LYS ASP ILE TYR GLY PRO GLY SEQRES 7 m 292 PHE LYS ASP ASN PHE GLN GLY ASP ILE ASP ILE ALA LYS SEQRES 8 m 292 ASN LEU ALA VAL LEU LYS ILE LEU ALA PRO SER GLU ARG SEQRES 9 m 292 ASP GLU GLY SER TYR TYR CYS ALA CYS ASP THR LEU GLY SEQRES 10 m 292 MET GLY GLY GLU TYR THR ASP LYS LEU ILE PHE GLY LYS SEQRES 11 m 292 GLY THR ARG VAL THR VAL GLU PRO ARG SER GLN PRO HIS SEQRES 12 m 292 THR LYS PRO SER VAL PHE VAL MET LYS ASN GLY THR ASN SEQRES 13 m 292 VAL ALA CYS LEU VAL LYS GLU PHE TYR PRO LYS ASP ILE SEQRES 14 m 292 ARG ILE ASN LEU VAL SER SER LYS LYS ILE THR GLU PHE SEQRES 15 m 292 ASP PRO ALA ILE VAL ILE SER PRO SER GLY LYS TYR ASN SEQRES 16 m 292 ALA VAL LYS LEU GLY LYS TYR GLU ASP SER ASN SER VAL SEQRES 17 m 292 THR CYS SER VAL GLN HIS ASP ASN LYS THR VAL HIS SER SEQRES 18 m 292 THR ASP PHE GLU VAL LYS THR ASP SER THR ASP HIS VAL SEQRES 19 m 292 LYS PRO LYS GLU THR GLU ASN THR LYS GLN PRO SER LYS SEQRES 20 m 292 SER CYS HIS LYS PRO LYS ALA ILE VAL HIS THR GLU LYS SEQRES 21 m 292 VAL ASN MET MET SER LEU THR VAL LEU GLY LEU ARG MET SEQRES 22 m 292 LEU PHE ALA LYS THR VAL ALA VAL ASN PHE LEU LEU THR SEQRES 23 m 292 ALA LYS LEU PHE PHE LEU SEQRES 1 n 315 MET LEU SER LEU LEU HIS THR SER THR LEU ALA VAL LEU SEQRES 2 n 315 GLY ALA LEU CYS VAL TYR GLY ALA GLY HIS LEU GLU GLN SEQRES 3 n 315 PRO GLN ILE SER SER THR LYS THR LEU SER LYS THR ALA SEQRES 4 n 315 ARG LEU GLU CYS VAL VAL SER GLY ILE THR ILE SER ALA SEQRES 5 n 315 THR SER VAL TYR TRP TYR ARG GLU ARG PRO GLY GLU VAL SEQRES 6 n 315 ILE GLN PHE LEU VAL SER ILE SER TYR ASP GLY THR VAL SEQRES 7 n 315 ARG LYS GLU SER GLY ILE PRO SER GLY LYS PHE GLU VAL SEQRES 8 n 315 ASP ARG ILE PRO GLU THR SER THR SER THR LEU THR ILE SEQRES 9 n 315 HIS ASN VAL GLU LYS GLN ASP ILE ALA THR TYR TYR CYS SEQRES 10 n 315 ALA LEU TRP GLU ALA GLN GLN GLU LEU GLY LYS LYS ILE SEQRES 11 n 315 LYS VAL PHE GLY PRO GLY THR LYS LEU ILE ILE THR ASP SEQRES 12 n 315 LYS GLN LEU ASP ALA ASP VAL SER PRO LYS PRO THR ILE SEQRES 13 n 315 PHE LEU PRO SER ILE ALA GLU THR LYS LEU GLN LYS ALA SEQRES 14 n 315 GLY THR TYR LEU CYS LEU LEU GLU LYS PHE PHE PRO ASP SEQRES 15 n 315 VAL ILE LYS ILE HIS TRP GLU GLU LYS LYS SER ASN THR SEQRES 16 n 315 ILE LEU GLY SER GLN GLU GLY ASN THR MET LYS THR ASN SEQRES 17 n 315 ASP THR TYR MET LYS PHE SER TRP LEU THR VAL PRO GLU SEQRES 18 n 315 LYS SER LEU ASP LYS GLU HIS ARG CYS ILE VAL ARG HIS SEQRES 19 n 315 GLU ASN ASN LYS ASN GLY VAL ASP GLN GLU ILE ILE PHE SEQRES 20 n 315 PRO PRO ILE LYS THR ASP VAL ILE THR MET ASP PRO LYS SEQRES 21 n 315 ASP ASN CYS SER LYS ASP ALA ASN ASP THR LEU LEU LEU SEQRES 22 n 315 GLN LEU THR ASN THR SER ALA TYR TYR MET TYR LEU LEU SEQRES 23 n 315 LEU LEU LEU LYS SER VAL VAL TYR PHE ALA ILE ILE THR SEQRES 24 n 315 CYS CYS LEU LEU ARG ARG THR ALA PHE CYS CYS ASN GLY SEQRES 25 n 315 GLU LYS SER SEQRES 1 R 222 GLU VAL GLN LEU GLN GLN SER GLY PRO GLU LEU VAL LYS SEQRES 2 R 222 PRO GLY ALA SER MET LYS ILE SER CYS LYS ALA SER GLY SEQRES 3 R 222 TYR SER PHE THR GLY TYR THR MET ASN TRP VAL LYS GLN SEQRES 4 R 222 SER HIS GLY LYS ASN LEU GLU TRP MET GLY LEU ILE ASN SEQRES 5 R 222 PRO TYR LYS GLY VAL SER THR TYR ASN GLN LYS PHE LYS SEQRES 6 R 222 ASP LYS ALA THR LEU THR VAL ASP LYS SER SER SER THR SEQRES 7 R 222 ALA TYR MET GLU LEU LEU SER LEU THR SER GLU ASP SER SEQRES 8 R 222 ALA VAL TYR TYR CYS ALA ARG SER GLY TYR TYR GLY ASP SEQRES 9 R 222 SER ASP TRP TYR PHE ASP VAL TRP GLY GLN GLY THR THR SEQRES 10 R 222 LEU THR VAL PHE SER ALA LYS THR THR PRO PRO SER VAL SEQRES 11 R 222 TYR PRO LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER SEQRES 12 R 222 MET VAL THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO SEQRES 13 R 222 GLU PRO VAL THR VAL THR TRP ASN SER GLY SER LEU SER SEQRES 14 R 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU LYS SER ASP SEQRES 15 R 222 LEU TYR THR LEU SER SER SER VAL THR VAL PRO SER SER SEQRES 16 R 222 PRO ARG PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS SEQRES 17 R 222 PRO ALA SER SER THR THR VAL ASP LYS LYS ILE VAL PRO SEQRES 18 R 222 ARG SEQRES 1 Q 212 ASP ILE GLN MET THR GLN THR THR SER SER LEU SER ALA SEQRES 2 Q 212 SER LEU GLY ASP ARG VAL THR ILE SER CYS ARG ALA SER SEQRES 3 Q 212 GLN ASP ILE ARG ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 Q 212 PRO ASP GLY THR VAL LYS LEU LEU ILE TYR TYR THR SER SEQRES 5 Q 212 ARG LEU HIS SER GLY VAL PRO SER LYS PHE SER GLY SER SEQRES 6 Q 212 GLY SER GLY THR ASP TYR SER LEU THR ILE SER ASN LEU SEQRES 7 Q 212 GLU GLN GLU ASP ILE ALA THR TYR PHE CYS GLN GLN GLY SEQRES 8 Q 212 ASN THR LEU PRO TRP THR PHE ALA GLY GLY THR LYS LEU SEQRES 9 Q 212 GLU ILE LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 Q 212 PHE PRO PRO ALA SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 Q 212 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS SER SEQRES 12 Q 212 ILE ASN SER LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 Q 212 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 Q 212 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 Q 212 LYS ASN GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 Q 212 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 Q 212 PHE ASN ARG SER SEQRES 1 A 166 MET LYS TRP LYS ALA LEU PHE THR ALA ALA ILE LEU GLN SEQRES 2 A 166 ALA GLN LEU PRO ILE THR GLU ALA GLN SER PHE GLY LEU SEQRES 3 A 166 LEU ASP PRO LYS LEU CYS TYR LEU LEU ASP GLY ILE LEU SEQRES 4 A 166 PHE ILE TYR GLY VAL ILE LEU THR ALA LEU PHE LEU ARG SEQRES 5 A 166 VAL LYS PHE SER ARG SER ALA ASP ALA PRO ALA TYR GLN SEQRES 6 A 166 GLN GLY GLN ASN GLN LEU TYR ASN GLU LEU ASN LEU GLY SEQRES 7 A 166 ARG ARG GLU GLU TYR ASP VAL LEU ASP LYS ARG ARG GLY SEQRES 8 A 166 ARG ASP PRO GLU MET GLY GLY LYS PRO GLN ARG ARG LYS SEQRES 9 A 166 ASN PRO GLN GLU GLY LEU TYR ASN GLU LEU GLN LYS ASP SEQRES 10 A 166 LYS MET ALA GLU ALA TYR SER GLU ILE GLY MET LYS GLY SEQRES 11 A 166 GLU ARG ARG ARG GLY LYS GLY HIS ASP GLY LEU TYR GLN SEQRES 12 A 166 GLY LEU SER THR ALA THR LYS ASP THR TYR ASP ALA LEU SEQRES 13 A 166 HIS MET GLN ALA LEU PRO PRO ARG SER ALA SEQRES 1 B 166 MET LYS TRP LYS ALA LEU PHE THR ALA ALA ILE LEU GLN SEQRES 2 B 166 ALA GLN LEU PRO ILE THR GLU ALA GLN SER PHE GLY LEU SEQRES 3 B 166 LEU ASP PRO LYS LEU CYS TYR LEU LEU ASP GLY ILE LEU SEQRES 4 B 166 PHE ILE TYR GLY VAL ILE LEU THR ALA LEU PHE LEU ARG SEQRES 5 B 166 VAL LYS PHE SER ARG SER ALA ASP ALA PRO ALA TYR GLN SEQRES 6 B 166 GLN GLY GLN ASN GLN LEU TYR ASN GLU LEU ASN LEU GLY SEQRES 7 B 166 ARG ARG GLU GLU TYR ASP VAL LEU ASP LYS ARG ARG GLY SEQRES 8 B 166 ARG ASP PRO GLU MET GLY GLY LYS PRO GLN ARG ARG LYS SEQRES 9 B 166 ASN PRO GLN GLU GLY LEU TYR ASN GLU LEU GLN LYS ASP SEQRES 10 B 166 LYS MET ALA GLU ALA TYR SER GLU ILE GLY MET LYS GLY SEQRES 11 B 166 GLU ARG ARG ARG GLY LYS GLY HIS ASP GLY LEU TYR GLN SEQRES 12 B 166 GLY LEU SER THR ALA THR LYS ASP THR TYR ASP ALA LEU SEQRES 13 B 166 HIS MET GLN ALA LEU PRO PRO ARG SER ALA SEQRES 1 D 171 MET GLU HIS SER THR PHE LEU SER GLY LEU VAL LEU ALA SEQRES 2 D 171 THR LEU LEU SER GLN VAL SER PRO PHE LYS ILE PRO ILE SEQRES 3 D 171 GLU GLU LEU GLU ASP ARG VAL PHE VAL ASN CYS ASN THR SEQRES 4 D 171 SER ILE THR TRP VAL GLU GLY THR VAL GLY THR LEU LEU SEQRES 5 D 171 SER ASP ILE THR ARG LEU ASP LEU GLY LYS ARG ILE LEU SEQRES 6 D 171 ASP PRO ARG GLY ILE TYR ARG CYS ASN GLY THR ASP ILE SEQRES 7 D 171 TYR LYS ASP LYS GLU SER THR VAL GLN VAL HIS TYR ARG SEQRES 8 D 171 MET CYS GLN SER CYS VAL GLU LEU ASP PRO ALA THR VAL SEQRES 9 D 171 ALA GLY ILE ILE VAL THR ASP VAL ILE ALA THR LEU LEU SEQRES 10 D 171 LEU ALA LEU GLY VAL PHE CYS PHE ALA GLY HIS GLU THR SEQRES 11 D 171 GLY ARG LEU SER GLY ALA ALA ASP THR GLN ALA LEU LEU SEQRES 12 D 171 ARG ASN ASP GLN VAL TYR GLN PRO LEU ARG ASP ARG ASP SEQRES 13 D 171 ASP ALA GLN TYR SER HIS LEU GLY GLY ASN TRP ALA ARG SEQRES 14 D 171 ASN LYS SEQRES 1 E 207 MET GLN SER GLY THR HIS TRP ARG VAL LEU GLY LEU CYS SEQRES 2 E 207 LEU LEU SER VAL GLY VAL TRP GLY GLN ASP GLY ASN GLU SEQRES 3 E 207 GLU MET GLY GLY ILE THR GLN THR PRO TYR LYS VAL SER SEQRES 4 E 207 ILE SER GLY THR THR VAL ILE LEU THR CYS PRO GLN TYR SEQRES 5 E 207 PRO GLY SER GLU ILE LEU TRP GLN HIS ASN ASP LYS ASN SEQRES 6 E 207 ILE GLY GLY ASP GLU ASP ASP LYS ASN ILE GLY SER ASP SEQRES 7 E 207 GLU ASP HIS LEU SER LEU LYS GLU PHE SER GLU LEU GLU SEQRES 8 E 207 GLN SER GLY TYR TYR VAL CYS TYR PRO ARG GLY SER LYS SEQRES 9 E 207 PRO GLU ASP ALA ASN PHE TYR LEU TYR LEU ARG ALA ARG SEQRES 10 E 207 VAL CYS GLU ASN CYS MET GLU MET ASP VAL MET SER VAL SEQRES 11 E 207 ALA THR ILE VAL ILE VAL ASP ILE CYS ILE THR GLY GLY SEQRES 12 E 207 LEU LEU LEU LEU VAL TYR TYR TRP SER LYS ASN ARG LYS SEQRES 13 E 207 ALA LYS ALA LYS PRO VAL THR ARG GLY ALA GLY ALA GLY SEQRES 14 E 207 GLY ARG GLN ARG GLY GLN ASN LYS GLU ARG PRO PRO PRO SEQRES 15 E 207 VAL PRO ASN PRO ASP TYR GLU PRO ILE ARG LYS GLY GLN SEQRES 16 E 207 ARG ASP LEU TYR SER GLY LEU ASN GLN ARG ARG ILE SEQRES 1 F 207 MET GLN SER GLY THR HIS TRP ARG VAL LEU GLY LEU CYS SEQRES 2 F 207 LEU LEU SER VAL GLY VAL TRP GLY GLN ASP GLY ASN GLU SEQRES 3 F 207 GLU MET GLY GLY ILE THR GLN THR PRO TYR LYS VAL SER SEQRES 4 F 207 ILE SER GLY THR THR VAL ILE LEU THR CYS PRO GLN TYR SEQRES 5 F 207 PRO GLY SER GLU ILE LEU TRP GLN HIS ASN ASP LYS ASN SEQRES 6 F 207 ILE GLY GLY ASP GLU ASP ASP LYS ASN ILE GLY SER ASP SEQRES 7 F 207 GLU ASP HIS LEU SER LEU LYS GLU PHE SER GLU LEU GLU SEQRES 8 F 207 GLN SER GLY TYR TYR VAL CYS TYR PRO ARG GLY SER LYS SEQRES 9 F 207 PRO GLU ASP ALA ASN PHE TYR LEU TYR LEU ARG ALA ARG SEQRES 10 F 207 VAL CYS GLU ASN CYS MET GLU MET ASP VAL MET SER VAL SEQRES 11 F 207 ALA THR ILE VAL ILE VAL ASP ILE CYS ILE THR GLY GLY SEQRES 12 F 207 LEU LEU LEU LEU VAL TYR TYR TRP SER LYS ASN ARG LYS SEQRES 13 F 207 ALA LYS ALA LYS PRO VAL THR ARG GLY ALA GLY ALA GLY SEQRES 14 F 207 GLY ARG GLN ARG GLY GLN ASN LYS GLU ARG PRO PRO PRO SEQRES 15 F 207 VAL PRO ASN PRO ASP TYR GLU PRO ILE ARG LYS GLY GLN SEQRES 16 F 207 ARG ASP LEU TYR SER GLY LEU ASN GLN ARG ARG ILE SEQRES 1 G 182 MET GLU GLN GLY LYS GLY LEU ALA VAL LEU ILE LEU ALA SEQRES 2 G 182 ILE ILE LEU LEU GLN GLY THR LEU ALA GLN SER ILE LYS SEQRES 3 G 182 GLY ASN HIS LEU VAL LYS VAL TYR ASP TYR GLN GLU ASP SEQRES 4 G 182 GLY SER VAL LEU LEU THR CYS ASP ALA GLU ALA LYS ASN SEQRES 5 G 182 ILE THR TRP PHE LYS ASP GLY LYS MET ILE GLY PHE LEU SEQRES 6 G 182 THR GLU ASP LYS LYS LYS TRP ASN LEU GLY SER ASN ALA SEQRES 7 G 182 LYS ASP PRO ARG GLY MET TYR GLN CYS LYS GLY SER GLN SEQRES 8 G 182 ASN LYS SER LYS PRO LEU GLN VAL TYR TYR ARG MET CYS SEQRES 9 G 182 GLN ASN CYS ILE GLU LEU ASN ALA ALA THR ILE SER GLY SEQRES 10 G 182 PHE LEU PHE ALA GLU ILE VAL SER ILE PHE VAL LEU ALA SEQRES 11 G 182 VAL GLY VAL TYR PHE ILE ALA GLY GLN ASP GLY VAL ARG SEQRES 12 G 182 GLN SER ARG ALA SER ASP LYS GLN THR LEU LEU PRO ASN SEQRES 13 G 182 ASP GLN LEU TYR GLN PRO LEU LYS ASP ARG GLU ASP ASP SEQRES 14 G 182 GLN TYR SER HIS LEU GLN GLY ASN GLN LEU ARG ARG ASN SEQRES 1 M 292 MET GLN ARG ILE SER SER LEU ILE HIS LEU SER LEU PHE SEQRES 2 M 292 TRP ALA GLY VAL MET SER ALA ILE GLU LEU VAL PRO GLU SEQRES 3 M 292 HIS GLN THR VAL PRO VAL SER ILE GLY VAL PRO ALA THR SEQRES 4 M 292 LEU ARG CYS SER MET LYS GLY GLU ALA ILE GLY ASN TYR SEQRES 5 M 292 TYR ILE ASN TRP TYR ARG LYS THR GLN GLY ASN THR MET SEQRES 6 M 292 THR PHE ILE TYR ARG GLU LYS ASP ILE TYR GLY PRO GLY SEQRES 7 M 292 PHE LYS ASP ASN PHE GLN GLY ASP ILE ASP ILE ALA LYS SEQRES 8 M 292 ASN LEU ALA VAL LEU LYS ILE LEU ALA PRO SER GLU ARG SEQRES 9 M 292 ASP GLU GLY SER TYR TYR CYS ALA CYS ASP THR LEU GLY SEQRES 10 M 292 MET GLY GLY GLU TYR THR ASP LYS LEU ILE PHE GLY LYS SEQRES 11 M 292 GLY THR ARG VAL THR VAL GLU PRO ARG SER GLN PRO HIS SEQRES 12 M 292 THR LYS PRO SER VAL PHE VAL MET LYS ASN GLY THR ASN SEQRES 13 M 292 VAL ALA CYS LEU VAL LYS GLU PHE TYR PRO LYS ASP ILE SEQRES 14 M 292 ARG ILE ASN LEU VAL SER SER LYS LYS ILE THR GLU PHE SEQRES 15 M 292 ASP PRO ALA ILE VAL ILE SER PRO SER GLY LYS TYR ASN SEQRES 16 M 292 ALA VAL LYS LEU GLY LYS TYR GLU ASP SER ASN SER VAL SEQRES 17 M 292 THR CYS SER VAL GLN HIS ASP ASN LYS THR VAL HIS SER SEQRES 18 M 292 THR ASP PHE GLU VAL LYS THR ASP SER THR ASP HIS VAL SEQRES 19 M 292 LYS PRO LYS GLU THR GLU ASN THR LYS GLN PRO SER LYS SEQRES 20 M 292 SER CYS HIS LYS PRO LYS ALA ILE VAL HIS THR GLU LYS SEQRES 21 M 292 VAL ASN MET MET SER LEU THR VAL LEU GLY LEU ARG MET SEQRES 22 M 292 LEU PHE ALA LYS THR VAL ALA VAL ASN PHE LEU LEU THR SEQRES 23 M 292 ALA LYS LEU PHE PHE LEU SEQRES 1 N 315 MET LEU SER LEU LEU HIS THR SER THR LEU ALA VAL LEU SEQRES 2 N 315 GLY ALA LEU CYS VAL TYR GLY ALA GLY HIS LEU GLU GLN SEQRES 3 N 315 PRO GLN ILE SER SER THR LYS THR LEU SER LYS THR ALA SEQRES 4 N 315 ARG LEU GLU CYS VAL VAL SER GLY ILE THR ILE SER ALA SEQRES 5 N 315 THR SER VAL TYR TRP TYR ARG GLU ARG PRO GLY GLU VAL SEQRES 6 N 315 ILE GLN PHE LEU VAL SER ILE SER TYR ASP GLY THR VAL SEQRES 7 N 315 ARG LYS GLU SER GLY ILE PRO SER GLY LYS PHE GLU VAL SEQRES 8 N 315 ASP ARG ILE PRO GLU THR SER THR SER THR LEU THR ILE SEQRES 9 N 315 HIS ASN VAL GLU LYS GLN ASP ILE ALA THR TYR TYR CYS SEQRES 10 N 315 ALA LEU TRP GLU ALA GLN GLN GLU LEU GLY LYS LYS ILE SEQRES 11 N 315 LYS VAL PHE GLY PRO GLY THR LYS LEU ILE ILE THR ASP SEQRES 12 N 315 LYS GLN LEU ASP ALA ASP VAL SER PRO LYS PRO THR ILE SEQRES 13 N 315 PHE LEU PRO SER ILE ALA GLU THR LYS LEU GLN LYS ALA SEQRES 14 N 315 GLY THR TYR LEU CYS LEU LEU GLU LYS PHE PHE PRO ASP SEQRES 15 N 315 VAL ILE LYS ILE HIS TRP GLU GLU LYS LYS SER ASN THR SEQRES 16 N 315 ILE LEU GLY SER GLN GLU GLY ASN THR MET LYS THR ASN SEQRES 17 N 315 ASP THR TYR MET LYS PHE SER TRP LEU THR VAL PRO GLU SEQRES 18 N 315 LYS SER LEU ASP LYS GLU HIS ARG CYS ILE VAL ARG HIS SEQRES 19 N 315 GLU ASN ASN LYS ASN GLY VAL ASP GLN GLU ILE ILE PHE SEQRES 20 N 315 PRO PRO ILE LYS THR ASP VAL ILE THR MET ASP PRO LYS SEQRES 21 N 315 ASP ASN CYS SER LYS ASP ALA ASN ASP THR LEU LEU LEU SEQRES 22 N 315 GLN LEU THR ASN THR SER ALA TYR TYR MET TYR LEU LEU SEQRES 23 N 315 LEU LEU LEU LYS SER VAL VAL TYR PHE ALA ILE ILE THR SEQRES 24 N 315 CYS CYS LEU LEU ARG ARG THR ALA PHE CYS CYS ASN GLY SEQRES 25 N 315 GLU LYS SER HET NAG d 201 14 HET NAG d 202 14 HET NAG D 201 14 HET NAG D 202 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 21 NAG 4(C8 H15 N O6) HELIX 1 AA1 SER P 28 TYR P 32 5 5 HELIX 2 AA2 THR P 87 SER P 91 5 5 HELIX 3 AA3 ALA O 122 GLY O 129 1 8 HELIX 4 AA4 LYS O 184 ARG O 189 1 6 HELIX 5 AA5 PRO a 29 LYS a 54 1 26 HELIX 6 AA6 ASP b 28 PHE b 55 1 28 HELIX 7 AA7 ILE d 64 ASP d 66 5 3 HELIX 8 AA8 ASP d 100 ALA d 126 1 27 HELIX 9 AA9 ASP e 126 LYS e 153 1 28 HELIX 10 AB1 ASP f 126 ASN f 154 1 29 HELIX 11 AB2 SER g 76 ASP g 80 5 5 HELIX 12 AB3 ASN g 111 ASP g 140 1 30 HELIX 13 AB4 THR m 256 PHE m 289 1 34 HELIX 14 AB5 THR n 252 THR n 288 1 37 HELIX 15 AB6 SER R 28 TYR R 32 5 5 HELIX 16 AB7 THR R 87 SER R 91 5 5 HELIX 17 AB8 ALA Q 122 GLY Q 129 1 8 HELIX 18 AB9 LYS Q 184 ARG Q 189 1 6 HELIX 19 AC1 PRO A 29 LYS A 54 1 26 HELIX 20 AC2 ASP B 28 PHE B 55 1 28 HELIX 21 AC3 ILE D 64 ASP D 66 5 3 HELIX 22 AC4 ASP D 100 ALA D 126 1 27 HELIX 23 AC5 ASP E 126 LYS E 153 1 28 HELIX 24 AC6 ASP F 126 ASN F 154 1 29 HELIX 25 AC7 SER G 76 ASP G 80 5 5 HELIX 26 AC8 ASN G 111 ASP G 140 1 30 HELIX 27 AC9 THR M 256 PHE M 289 1 34 HELIX 28 AD1 THR N 252 THR N 288 1 37 SHEET 1 AA1 4 GLN P 3 GLN P 6 0 SHEET 2 AA1 4 MET P 18 SER P 25 -1 O SER P 25 N GLN P 3 SHEET 3 AA1 4 THR P 78 LEU P 83 -1 O MET P 81 N ILE P 20 SHEET 4 AA1 4 ALA P 68 ASP P 73 -1 N ASP P 73 O THR P 78 SHEET 1 AA2 6 GLU P 10 VAL P 12 0 SHEET 2 AA2 6 THR P 116 VAL P 120 1 O THR P 117 N GLU P 10 SHEET 3 AA2 6 VAL P 93 SER P 99 -1 N TYR P 94 O THR P 116 SHEET 4 AA2 6 THR P 33 SER P 40 -1 N ASN P 35 O ALA P 97 SHEET 5 AA2 6 ASN P 44 ILE P 51 -1 O GLU P 46 N LYS P 38 SHEET 6 AA2 6 SER P 58 TYR P 60 -1 O THR P 59 N LEU P 50 SHEET 1 AA3 4 GLU P 10 VAL P 12 0 SHEET 2 AA3 4 THR P 116 VAL P 120 1 O THR P 117 N GLU P 10 SHEET 3 AA3 4 VAL P 93 SER P 99 -1 N TYR P 94 O THR P 116 SHEET 4 AA3 4 PHE P 109 TRP P 112 -1 O VAL P 111 N ARG P 98 SHEET 1 AA4 3 SER P 129 LEU P 133 0 SHEET 2 AA4 3 GLY P 148 TYR P 154 -1 O LYS P 152 N SER P 129 SHEET 3 AA4 3 TYR P 184 SER P 189 -1 O TYR P 184 N TYR P 154 SHEET 1 AA5 3 THR P 160 TRP P 163 0 SHEET 2 AA5 3 THR P 203 HIS P 208 -1 O ALA P 207 N THR P 160 SHEET 3 AA5 3 THR P 213 LYS P 218 -1 O LYS P 217 N CYS P 204 SHEET 1 AA6 4 MET O 4 THR O 5 0 SHEET 2 AA6 4 VAL O 19 ALA O 25 -1 O ARG O 24 N THR O 5 SHEET 3 AA6 4 ASP O 70 ILE O 75 -1 O ILE O 75 N VAL O 19 SHEET 4 AA6 4 PHE O 62 SER O 67 -1 N SER O 63 O THR O 74 SHEET 1 AA7 6 SER O 10 SER O 12 0 SHEET 2 AA7 6 THR O 102 GLU O 105 1 O LYS O 103 N LEU O 11 SHEET 3 AA7 6 THR O 85 GLN O 90 -1 N TYR O 86 O THR O 102 SHEET 4 AA7 6 LEU O 33 GLN O 38 -1 N GLN O 38 O THR O 85 SHEET 5 AA7 6 VAL O 44 TYR O 49 -1 O LEU O 47 N TRP O 35 SHEET 6 AA7 6 ARG O 53 LEU O 54 -1 O ARG O 53 N TYR O 49 SHEET 1 AA8 4 ILE O 118 PHE O 119 0 SHEET 2 AA8 4 GLY O 130 CYS O 135 -1 O VAL O 134 N PHE O 119 SHEET 3 AA8 4 MET O 176 THR O 183 -1 O LEU O 182 N ALA O 131 SHEET 4 AA8 4 VAL O 160 TRP O 164 -1 N SER O 163 O SER O 177 SHEET 1 AA9 4 SER O 154 GLU O 155 0 SHEET 2 AA9 4 SER O 147 ILE O 151 -1 N ILE O 151 O SER O 154 SHEET 3 AA9 4 SER O 192 ALA O 197 -1 O THR O 194 N LYS O 150 SHEET 4 AA9 4 ILE O 206 ASN O 211 -1 O ILE O 206 N ALA O 197 SHEET 1 AB1 4 ILE d 26 LEU d 29 0 SHEET 2 AB1 4 ARG d 32 ASN d 36 -1 O PHE d 34 N GLU d 27 SHEET 3 AB1 4 ARG d 57 LYS d 62 -1 O LEU d 58 N VAL d 35 SHEET 4 AB1 4 THR d 50 LEU d 51 -1 N THR d 50 O ASP d 59 SHEET 1 AB2 7 THR d 42 GLY d 46 0 SHEET 2 AB2 7 ARG d 68 CYS d 73 -1 O ILE d 70 N GLU d 45 SHEET 3 AB2 7 SER d 84 ARG d 91 -1 O VAL d 86 N TYR d 71 SHEET 4 AB2 7 PHE e 110 ALA e 116 1 O TYR e 111 N GLN d 87 SHEET 5 AB2 7 GLY e 94 PRO e 100 -1 N TYR e 96 O LEU e 112 SHEET 6 AB2 7 ILE e 57 HIS e 61 -1 N LEU e 58 O TYR e 99 SHEET 7 AB2 7 LYS e 64 ILE e 66 -1 O LYS e 64 N HIS e 61 SHEET 1 AB3 2 CYS d 96 GLU d 98 0 SHEET 2 AB3 2 CYS e 122 GLU e 124 -1 O MET e 123 N VAL d 97 SHEET 1 AB4 4 LYS e 37 SER e 41 0 SHEET 2 AB4 4 THR e 44 THR e 48 -1 O ILE e 46 N SER e 39 SHEET 3 AB4 4 HIS e 81 LEU e 84 -1 O LEU e 82 N LEU e 47 SHEET 4 AB4 4 ILE e 75 ASP e 78 -1 N GLY e 76 O SER e 83 SHEET 1 AB5 4 LYS f 37 SER f 41 0 SHEET 2 AB5 4 THR f 44 THR f 48 -1 O ILE f 46 N SER f 39 SHEET 3 AB5 4 HIS f 81 LEU f 84 -1 O LEU f 82 N LEU f 47 SHEET 4 AB5 4 GLY f 76 SER f 77 -1 N GLY f 76 O SER f 83 SHEET 1 AB6 3 LYS f 64 ASN f 65 0 SHEET 2 AB6 3 LEU f 58 HIS f 61 -1 N HIS f 61 O LYS f 64 SHEET 3 AB6 3 TYR f 96 TYR f 99 -1 O VAL f 97 N GLN f 60 SHEET 1 AB7 3 LEU f 112 ALA f 116 0 SHEET 2 AB7 3 LYS g 93 ARG g 102 1 O TYR g 100 N TYR f 113 SHEET 3 AB7 3 GLY g 83 LYS g 88 -1 N CYS g 87 O SER g 94 SHEET 1 AB8 3 VAL g 31 TYR g 34 0 SHEET 2 AB8 3 VAL g 42 CYS g 46 -1 O THR g 45 N LYS g 32 SHEET 3 AB8 3 LYS g 71 GLY g 75 -1 O GLY g 75 N VAL g 42 SHEET 1 AB9 2 TRP g 55 LYS g 57 0 SHEET 2 AB9 2 LYS g 60 GLY g 63 -1 O LYS g 60 N LYS g 57 SHEET 1 AC1 4 GLN R 3 GLN R 6 0 SHEET 2 AC1 4 MET R 18 SER R 25 -1 O SER R 25 N GLN R 3 SHEET 3 AC1 4 THR R 78 LEU R 83 -1 O MET R 81 N ILE R 20 SHEET 4 AC1 4 ALA R 68 ASP R 73 -1 N ASP R 73 O THR R 78 SHEET 1 AC2 6 GLU R 10 VAL R 12 0 SHEET 2 AC2 6 THR R 116 VAL R 120 1 O THR R 117 N GLU R 10 SHEET 3 AC2 6 VAL R 93 SER R 99 -1 N TYR R 94 O THR R 116 SHEET 4 AC2 6 THR R 33 SER R 40 -1 N ASN R 35 O ALA R 97 SHEET 5 AC2 6 ASN R 44 ILE R 51 -1 O GLU R 46 N LYS R 38 SHEET 6 AC2 6 SER R 58 TYR R 60 -1 O THR R 59 N LEU R 50 SHEET 1 AC3 4 GLU R 10 VAL R 12 0 SHEET 2 AC3 4 THR R 116 VAL R 120 1 O THR R 117 N GLU R 10 SHEET 3 AC3 4 VAL R 93 SER R 99 -1 N TYR R 94 O THR R 116 SHEET 4 AC3 4 PHE R 109 TRP R 112 -1 O VAL R 111 N ARG R 98 SHEET 1 AC4 3 SER R 129 LEU R 133 0 SHEET 2 AC4 3 GLY R 148 TYR R 154 -1 O LYS R 152 N SER R 129 SHEET 3 AC4 3 TYR R 184 SER R 189 -1 O TYR R 184 N TYR R 154 SHEET 1 AC5 3 THR R 160 TRP R 163 0 SHEET 2 AC5 3 THR R 203 HIS R 208 -1 O ALA R 207 N THR R 160 SHEET 3 AC5 3 THR R 213 LYS R 218 -1 O LYS R 217 N CYS R 204 SHEET 1 AC6 4 MET Q 4 THR Q 5 0 SHEET 2 AC6 4 VAL Q 19 ALA Q 25 -1 O ARG Q 24 N THR Q 5 SHEET 3 AC6 4 ASP Q 70 ILE Q 75 -1 O ILE Q 75 N VAL Q 19 SHEET 4 AC6 4 PHE Q 62 SER Q 67 -1 N SER Q 63 O THR Q 74 SHEET 1 AC7 6 SER Q 10 SER Q 12 0 SHEET 2 AC7 6 THR Q 102 GLU Q 105 1 O LYS Q 103 N LEU Q 11 SHEET 3 AC7 6 THR Q 85 GLN Q 90 -1 N TYR Q 86 O THR Q 102 SHEET 4 AC7 6 LEU Q 33 GLN Q 38 -1 N GLN Q 38 O THR Q 85 SHEET 5 AC7 6 VAL Q 44 TYR Q 49 -1 O LEU Q 47 N TRP Q 35 SHEET 6 AC7 6 ARG Q 53 LEU Q 54 -1 O ARG Q 53 N TYR Q 49 SHEET 1 AC8 4 ILE Q 118 PHE Q 119 0 SHEET 2 AC8 4 GLY Q 130 CYS Q 135 -1 O VAL Q 134 N PHE Q 119 SHEET 3 AC8 4 MET Q 176 THR Q 183 -1 O LEU Q 182 N ALA Q 131 SHEET 4 AC8 4 VAL Q 160 TRP Q 164 -1 N SER Q 163 O SER Q 177 SHEET 1 AC9 4 SER Q 154 GLU Q 155 0 SHEET 2 AC9 4 SER Q 147 ILE Q 151 -1 N ILE Q 151 O SER Q 154 SHEET 3 AC9 4 SER Q 192 ALA Q 197 -1 O THR Q 194 N LYS Q 150 SHEET 4 AC9 4 ILE Q 206 ASN Q 211 -1 O ILE Q 206 N ALA Q 197 SHEET 1 AD1 4 ILE D 26 LEU D 29 0 SHEET 2 AD1 4 ARG D 32 ASN D 36 -1 O PHE D 34 N GLU D 27 SHEET 3 AD1 4 ARG D 57 LYS D 62 -1 O LEU D 58 N VAL D 35 SHEET 4 AD1 4 THR D 50 LEU D 51 -1 N THR D 50 O ASP D 59 SHEET 1 AD2 7 THR D 42 GLY D 46 0 SHEET 2 AD2 7 ARG D 68 CYS D 73 -1 O ILE D 70 N GLU D 45 SHEET 3 AD2 7 SER D 84 ARG D 91 -1 O VAL D 86 N TYR D 71 SHEET 4 AD2 7 PHE E 110 ALA E 116 1 O TYR E 111 N GLN D 87 SHEET 5 AD2 7 GLY E 94 PRO E 100 -1 N TYR E 96 O LEU E 112 SHEET 6 AD2 7 ILE E 57 HIS E 61 -1 N LEU E 58 O TYR E 99 SHEET 7 AD2 7 LYS E 64 ILE E 66 -1 O LYS E 64 N HIS E 61 SHEET 1 AD3 2 CYS D 96 GLU D 98 0 SHEET 2 AD3 2 CYS E 122 GLU E 124 -1 O MET E 123 N VAL D 97 SHEET 1 AD4 4 LYS E 37 SER E 41 0 SHEET 2 AD4 4 THR E 44 THR E 48 -1 O ILE E 46 N SER E 39 SHEET 3 AD4 4 HIS E 81 LEU E 84 -1 O LEU E 82 N LEU E 47 SHEET 4 AD4 4 ILE E 75 ASP E 78 -1 N GLY E 76 O SER E 83 SHEET 1 AD5 4 LYS F 37 SER F 41 0 SHEET 2 AD5 4 THR F 44 THR F 48 -1 O ILE F 46 N SER F 39 SHEET 3 AD5 4 HIS F 81 LEU F 84 -1 O LEU F 82 N LEU F 47 SHEET 4 AD5 4 GLY F 76 SER F 77 -1 N GLY F 76 O SER F 83 SHEET 1 AD6 3 LYS F 64 ASN F 65 0 SHEET 2 AD6 3 LEU F 58 HIS F 61 -1 N HIS F 61 O LYS F 64 SHEET 3 AD6 3 TYR F 96 TYR F 99 -1 O VAL F 97 N GLN F 60 SHEET 1 AD7 3 LEU F 112 ALA F 116 0 SHEET 2 AD7 3 LYS G 93 ARG G 102 1 O TYR G 100 N TYR F 113 SHEET 3 AD7 3 GLY G 83 LYS G 88 -1 N CYS G 87 O SER G 94 SHEET 1 AD8 3 VAL G 31 TYR G 34 0 SHEET 2 AD8 3 VAL G 42 CYS G 46 -1 O THR G 45 N LYS G 32 SHEET 3 AD8 3 LYS G 71 GLY G 75 -1 O GLY G 75 N VAL G 42 SHEET 1 AD9 2 TRP G 55 LYS G 57 0 SHEET 2 AD9 2 LYS G 60 GLY G 63 -1 O LYS G 60 N LYS G 57 SSBOND 1 CYS P 22 CYS P 96 1555 1555 2.03 SSBOND 2 CYS P 149 CYS P 204 1555 1555 2.03 SSBOND 3 CYS O 23 CYS O 88 1555 1555 2.03 SSBOND 4 CYS O 135 CYS O 195 1555 1555 2.03 SSBOND 5 CYS d 37 CYS d 73 1555 1555 2.03 SSBOND 6 CYS d 93 CYS d 96 1555 1555 2.03 SSBOND 7 CYS e 49 CYS e 98 1555 1555 2.04 SSBOND 8 CYS f 49 CYS f 98 1555 1555 2.03 SSBOND 9 CYS f 119 CYS f 122 1555 1555 2.03 SSBOND 10 CYS g 46 CYS g 87 1555 1555 2.03 SSBOND 11 CYS g 104 CYS g 107 1555 1555 2.03 SSBOND 12 CYS R 22 CYS R 96 1555 1555 2.03 SSBOND 13 CYS R 149 CYS R 204 1555 1555 2.03 SSBOND 14 CYS Q 23 CYS Q 88 1555 1555 2.03 SSBOND 15 CYS Q 135 CYS Q 195 1555 1555 2.03 SSBOND 16 CYS D 37 CYS D 73 1555 1555 2.03 SSBOND 17 CYS D 93 CYS D 96 1555 1555 2.03 SSBOND 18 CYS E 49 CYS E 98 1555 1555 2.04 SSBOND 19 CYS F 49 CYS F 98 1555 1555 2.03 SSBOND 20 CYS F 119 CYS F 122 1555 1555 2.03 SSBOND 21 CYS G 46 CYS G 87 1555 1555 2.03 SSBOND 22 CYS G 104 CYS G 107 1555 1555 2.03 LINK ND2 ASN d 38 C1 NAG d 202 1555 1555 1.44 LINK ND2 ASN d 74 C1 NAG d 201 1555 1555 1.45 LINK ND2 ASN D 38 C1 NAG D 202 1555 1555 1.45 LINK ND2 ASN D 74 C1 NAG D 201 1555 1555 1.45 CISPEP 1 LEU O 94 PRO O 95 0 0.24 CISPEP 2 ARG O 108 ALA O 110 0 20.60 CISPEP 3 TYR O 141 PRO O 142 0 8.99 CISPEP 4 LEU Q 94 PRO Q 95 0 0.24 CISPEP 5 TYR Q 141 PRO Q 142 0 5.43 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000