HEADER MEMBRANE PROTEIN 10-NOV-24 9KHH TITLE STRUCTURE OF THE COMPLEX OF LGR4 WITH NORRIN (2:2) COMPND MOL_ID: 1; COMPND 2 MOLECULE: MB52; COMPND 3 CHAIN: A, B; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: NORRIN,IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN; COMPND 7 CHAIN: E, F; COMPND 8 SYNONYM: NORRIE DISEASE PROTEIN,X-LINKED EXUDATIVE VITREORETINOPATHY COMPND 9 2 PROTEIN,IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN NIE; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR COMPND 13 4; COMPND 14 CHAIN: C, D; COMPND 15 SYNONYM: G-PROTEIN COUPLED RECEPTOR 48; COMPND 16 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; SOURCE 3 ORGANISM_TAXID: 9838; SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_COMMON: HUMAN; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 GENE: NDP, EVR2; SOURCE 11 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_COMMON: HUMAN; SOURCE 16 ORGANISM_TAXID: 9606; SOURCE 17 GENE: LGR4, GPR48; SOURCE 18 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS LGR4 NORRIN, MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR G.YONG,F.Z.HU,H.R.QIAO REVDAT 1 16-JUL-25 9KHH 0 JRNL AUTH G.YONG,F.Z.HU,H.R.QIAO JRNL TITL STRUCTURE OF THE COMPLEX OF LGR4 WITH NORRIN (2:2) JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.65 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.650 REMARK 3 NUMBER OF PARTICLES : 771783 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING ONLY REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9KHH COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 11-NOV-24. REMARK 100 THE DEPOSITION ID IS D_1300053594. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : STRUCTURE OF THE COMPLEX OF REMARK 245 LGR4 WITH NORRIN (2:2) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TALOS ARCTICA REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 7000.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, E, F, B, C, D REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -18 REMARK 465 LYS A -17 REMARK 465 LYS A -16 REMARK 465 ILE A -15 REMARK 465 TRP A -14 REMARK 465 LEU A -13 REMARK 465 ALA A -12 REMARK 465 LEU A -11 REMARK 465 ALA A -10 REMARK 465 GLY A -9 REMARK 465 LEU A -8 REMARK 465 VAL A -7 REMARK 465 LEU A -6 REMARK 465 ALA A -5 REMARK 465 PHE A -4 REMARK 465 SER A -3 REMARK 465 ALA A -2 REMARK 465 SER A -1 REMARK 465 ALA A 0 REMARK 465 GLN A 1 REMARK 465 VAL A 2 REMARK 465 GLN A 3 REMARK 465 LEU A 4 REMARK 465 VAL A 5 REMARK 465 GLU A 6 REMARK 465 SER A 7 REMARK 465 GLY A 8 REMARK 465 GLY A 9 REMARK 465 GLY A 10 REMARK 465 LEU A 11 REMARK 465 VAL A 12 REMARK 465 GLN A 13 REMARK 465 THR A 14 REMARK 465 LYS A 15 REMARK 465 THR A 16 REMARK 465 THR A 17 REMARK 465 THR A 18 REMARK 465 SER A 19 REMARK 465 VAL A 20 REMARK 465 ILE A 21 REMARK 465 ASP A 22 REMARK 465 THR A 23 REMARK 465 THR A 24 REMARK 465 ASN A 25 REMARK 465 ASP A 26 REMARK 465 ALA A 27 REMARK 465 GLN A 28 REMARK 465 ASN A 29 REMARK 465 LEU A 30 REMARK 465 LEU A 31 REMARK 465 THR A 32 REMARK 465 GLN A 33 REMARK 465 ALA A 34 REMARK 465 GLN A 35 REMARK 465 THR A 36 REMARK 465 ILE A 37 REMARK 465 VAL A 38 REMARK 465 ASN A 39 REMARK 465 THR A 40 REMARK 465 LEU A 41 REMARK 465 LYS A 42 REMARK 465 ASP A 43 REMARK 465 TYR A 44 REMARK 465 CYS A 45 REMARK 465 PRO A 46 REMARK 465 ILE A 47 REMARK 465 LEU A 48 REMARK 465 ILE A 49 REMARK 465 ALA A 50 REMARK 465 LYS A 51 REMARK 465 SER A 52 REMARK 465 SER A 53 REMARK 465 SER A 54 REMARK 465 SER A 55 REMARK 465 ASN A 56 REMARK 465 GLY A 57 REMARK 465 GLY A 58 REMARK 465 THR A 59 REMARK 465 ASN A 60 REMARK 465 ASN A 61 REMARK 465 ALA A 62 REMARK 465 ASN A 63 REMARK 465 THR A 64 REMARK 465 PRO A 65 REMARK 465 SER A 66 REMARK 465 TRP A 67 REMARK 465 GLN A 68 REMARK 465 THR A 69 REMARK 465 ALA A 70 REMARK 465 GLY A 71 REMARK 465 GLY A 72 REMARK 465 GLY A 73 REMARK 465 LYS A 74 REMARK 465 ASN A 75 REMARK 465 SER A 76 REMARK 465 CYS A 77 REMARK 465 ALA A 78 REMARK 465 THR A 79 REMARK 465 PHE A 80 REMARK 465 GLY A 81 REMARK 465 ALA A 82 REMARK 465 GLU A 83 REMARK 465 PHE A 84 REMARK 465 SER A 85 REMARK 465 ALA A 86 REMARK 465 ALA A 87 REMARK 465 SER A 88 REMARK 465 ASP A 89 REMARK 465 MET A 90 REMARK 465 ILE A 91 REMARK 465 ASN A 92 REMARK 465 ASN A 93 REMARK 465 ALA A 94 REMARK 465 GLN A 95 REMARK 465 LYS A 96 REMARK 465 ILE A 97 REMARK 465 VAL A 98 REMARK 465 GLN A 99 REMARK 465 GLU A 100 REMARK 465 THR A 101 REMARK 465 GLN A 102 REMARK 465 GLN A 103 REMARK 465 LEU A 104 REMARK 465 SER A 105 REMARK 465 ALA A 106 REMARK 465 ASN A 107 REMARK 465 GLN A 108 REMARK 465 PRO A 109 REMARK 465 LYS A 110 REMARK 465 ASN A 111 REMARK 465 ILE A 112 REMARK 465 THR A 113 REMARK 465 GLN A 114 REMARK 465 PRO A 115 REMARK 465 HIS A 116 REMARK 465 ASN A 117 REMARK 465 LEU A 118 REMARK 465 ASN A 119 REMARK 465 LEU A 120 REMARK 465 ASN A 121 REMARK 465 SER A 122 REMARK 465 PRO A 123 REMARK 465 SER A 124 REMARK 465 SER A 125 REMARK 465 LEU A 126 REMARK 465 THR A 127 REMARK 465 ALA A 128 REMARK 465 LEU A 129 REMARK 465 ALA A 130 REMARK 465 GLN A 131 REMARK 465 LYS A 132 REMARK 465 MET A 133 REMARK 465 LEU A 134 REMARK 465 LYS A 135 REMARK 465 ASN A 136 REMARK 465 ALA A 137 REMARK 465 GLN A 138 REMARK 465 SER A 139 REMARK 465 GLN A 140 REMARK 465 ALA A 141 REMARK 465 GLU A 142 REMARK 465 ILE A 143 REMARK 465 LEU A 144 REMARK 465 LYS A 145 REMARK 465 LEU A 146 REMARK 465 ALA A 147 REMARK 465 ASN A 148 REMARK 465 GLN A 149 REMARK 465 VAL A 150 REMARK 465 GLU A 151 REMARK 465 SER A 152 REMARK 465 ASP A 153 REMARK 465 PHE A 154 REMARK 465 ASN A 155 REMARK 465 LYS A 156 REMARK 465 LEU A 157 REMARK 465 SER A 158 REMARK 465 SER A 159 REMARK 465 GLY A 160 REMARK 465 HIS A 161 REMARK 465 LEU A 162 REMARK 465 LYS A 163 REMARK 465 ASP A 164 REMARK 465 TYR A 165 REMARK 465 ILE A 166 REMARK 465 GLY A 167 REMARK 465 LYS A 168 REMARK 465 CYS A 169 REMARK 465 ASP A 170 REMARK 465 ALA A 171 REMARK 465 SER A 172 REMARK 465 ALA A 173 REMARK 465 ILE A 174 REMARK 465 SER A 175 REMARK 465 SER A 176 REMARK 465 ALA A 177 REMARK 465 ASN A 178 REMARK 465 MET A 179 REMARK 465 THR A 180 REMARK 465 MET A 181 REMARK 465 GLN A 182 REMARK 465 ASN A 183 REMARK 465 GLN A 184 REMARK 465 LYS A 185 REMARK 465 ASN A 186 REMARK 465 ASN A 187 REMARK 465 TRP A 188 REMARK 465 GLY A 189 REMARK 465 ASN A 190 REMARK 465 GLY A 191 REMARK 465 CYS A 192 REMARK 465 ALA A 193 REMARK 465 GLY A 194 REMARK 465 VAL A 195 REMARK 465 GLU A 196 REMARK 465 GLU A 197 REMARK 465 THR A 198 REMARK 465 GLN A 199 REMARK 465 SER A 200 REMARK 465 LEU A 201 REMARK 465 LEU A 202 REMARK 465 LYS A 203 REMARK 465 THR A 204 REMARK 465 SER A 205 REMARK 465 ALA A 206 REMARK 465 ALA A 207 REMARK 465 ASP A 208 REMARK 465 PHE A 209 REMARK 465 ASN A 210 REMARK 465 ASN A 211 REMARK 465 GLN A 212 REMARK 465 THR A 213 REMARK 465 PRO A 214 REMARK 465 GLN A 215 REMARK 465 ILE A 216 REMARK 465 ASN A 217 REMARK 465 GLN A 218 REMARK 465 ALA A 219 REMARK 465 GLN A 220 REMARK 465 ASN A 221 REMARK 465 LEU A 222 REMARK 465 ALA A 223 REMARK 465 ASN A 224 REMARK 465 THR A 225 REMARK 465 LEU A 226 REMARK 465 ILE A 227 REMARK 465 GLN A 228 REMARK 465 GLU A 229 REMARK 465 LEU A 230 REMARK 465 GLY A 231 REMARK 465 ASN A 232 REMARK 465 ASN A 233 REMARK 465 PRO A 234 REMARK 465 PHE A 235 REMARK 465 ARG A 236 REMARK 465 ALA A 237 REMARK 465 SER A 238 REMARK 465 GLY A 239 REMARK 465 GLY A 240 REMARK 465 GLY A 241 REMARK 465 SER A 242 REMARK 465 GLY A 243 REMARK 465 GLY A 244 REMARK 465 GLY A 245 REMARK 465 GLY A 246 REMARK 465 SER A 247 REMARK 465 GLY A 248 REMARK 465 LYS A 249 REMARK 465 LEU A 250 REMARK 465 SER A 251 REMARK 465 ASP A 252 REMARK 465 THR A 253 REMARK 465 TYR A 254 REMARK 465 GLU A 255 REMARK 465 GLN A 256 REMARK 465 LEU A 257 REMARK 465 SER A 258 REMARK 465 ARG A 259 REMARK 465 LEU A 260 REMARK 465 LEU A 261 REMARK 465 THR A 262 REMARK 465 ASN A 263 REMARK 465 ASP A 264 REMARK 465 ASN A 265 REMARK 465 GLY A 266 REMARK 465 THR A 267 REMARK 465 ASN A 268 REMARK 465 SER A 269 REMARK 465 LYS A 270 REMARK 465 THR A 271 REMARK 465 SER A 272 REMARK 465 ALA A 273 REMARK 465 GLN A 274 REMARK 465 ALA A 275 REMARK 465 ILE A 276 REMARK 465 ASN A 277 REMARK 465 GLN A 278 REMARK 465 ALA A 279 REMARK 465 VAL A 280 REMARK 465 ASN A 281 REMARK 465 ASN A 282 REMARK 465 LEU A 283 REMARK 465 ASN A 284 REMARK 465 GLU A 285 REMARK 465 ARG A 286 REMARK 465 ALA A 287 REMARK 465 LYS A 288 REMARK 465 THR A 289 REMARK 465 LEU A 290 REMARK 465 ALA A 291 REMARK 465 GLY A 292 REMARK 465 GLY A 293 REMARK 465 THR A 294 REMARK 465 THR A 295 REMARK 465 ASN A 296 REMARK 465 SER A 297 REMARK 465 PRO A 298 REMARK 465 ALA A 299 REMARK 465 TYR A 300 REMARK 465 GLN A 301 REMARK 465 ALA A 302 REMARK 465 THR A 303 REMARK 465 LEU A 304 REMARK 465 LEU A 305 REMARK 465 ALA A 306 REMARK 465 LEU A 307 REMARK 465 ARG A 308 REMARK 465 SER A 309 REMARK 465 VAL A 310 REMARK 465 LEU A 311 REMARK 465 GLY A 312 REMARK 465 LEU A 313 REMARK 465 TRP A 314 REMARK 465 ASN A 315 REMARK 465 SER A 316 REMARK 465 MET A 317 REMARK 465 GLY A 318 REMARK 465 TYR A 319 REMARK 465 ALA A 320 REMARK 465 VAL A 321 REMARK 465 ILE A 322 REMARK 465 CYS A 323 REMARK 465 GLY A 324 REMARK 465 GLY A 325 REMARK 465 TYR A 326 REMARK 465 THR A 327 REMARK 465 LYS A 328 REMARK 465 SER A 329 REMARK 465 PRO A 330 REMARK 465 GLY A 331 REMARK 465 GLU A 332 REMARK 465 ASN A 333 REMARK 465 ASN A 334 REMARK 465 GLN A 335 REMARK 465 LYS A 336 REMARK 465 ASP A 337 REMARK 465 PHE A 338 REMARK 465 HIS A 339 REMARK 465 TYR A 340 REMARK 465 THR A 341 REMARK 465 ASP A 342 REMARK 465 GLU A 343 REMARK 465 ASN A 344 REMARK 465 GLY A 345 REMARK 465 ASN A 346 REMARK 465 GLY A 347 REMARK 465 THR A 348 REMARK 465 THR A 349 REMARK 465 ILE A 350 REMARK 465 ASN A 351 REMARK 465 CYS A 352 REMARK 465 GLY A 353 REMARK 465 GLY A 354 REMARK 465 SER A 355 REMARK 465 THR A 356 REMARK 465 ASN A 357 REMARK 465 SER A 358 REMARK 465 ASN A 359 REMARK 465 GLY A 360 REMARK 465 THR A 361 REMARK 465 HIS A 362 REMARK 465 SER A 363 REMARK 465 TYR A 364 REMARK 465 ASN A 365 REMARK 465 GLY A 366 REMARK 465 THR A 367 REMARK 465 ASN A 368 REMARK 465 THR A 369 REMARK 465 LEU A 370 REMARK 465 LYS A 371 REMARK 465 ALA A 372 REMARK 465 ASP A 373 REMARK 465 LYS A 374 REMARK 465 ASN A 375 REMARK 465 VAL A 376 REMARK 465 SER A 377 REMARK 465 LEU A 378 REMARK 465 SER A 379 REMARK 465 ILE A 380 REMARK 465 GLU A 381 REMARK 465 GLN A 382 REMARK 465 TYR A 383 REMARK 465 GLU A 384 REMARK 465 LYS A 385 REMARK 465 ILE A 386 REMARK 465 HIS A 387 REMARK 465 GLU A 388 REMARK 465 ALA A 389 REMARK 465 TYR A 390 REMARK 465 GLN A 391 REMARK 465 ILE A 392 REMARK 465 LEU A 393 REMARK 465 SER A 394 REMARK 465 LYS A 395 REMARK 465 ALA A 396 REMARK 465 LEU A 397 REMARK 465 LYS A 398 REMARK 465 GLN A 399 REMARK 465 ALA A 400 REMARK 465 GLY A 401 REMARK 465 LEU A 402 REMARK 465 ALA A 403 REMARK 465 PRO A 404 REMARK 465 LEU A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 LYS A 408 REMARK 465 GLY A 409 REMARK 465 GLU A 410 REMARK 465 LYS A 411 REMARK 465 LEU A 412 REMARK 465 GLU A 413 REMARK 465 ALA A 414 REMARK 465 HIS A 415 REMARK 465 VAL A 416 REMARK 465 THR A 417 REMARK 465 THR A 418 REMARK 465 SER A 419 REMARK 465 LYS A 420 REMARK 465 TYR A 421 REMARK 465 SER A 531 REMARK 465 HIS A 532 REMARK 465 HIS A 533 REMARK 465 HIS A 534 REMARK 465 HIS A 535 REMARK 465 HIS A 536 REMARK 465 HIS A 537 REMARK 465 MET E -13 REMARK 465 LEU E -12 REMARK 465 LEU E -11 REMARK 465 VAL E -10 REMARK 465 ASN E -9 REMARK 465 GLN E -8 REMARK 465 SER E -7 REMARK 465 HIS E -6 REMARK 465 GLN E -5 REMARK 465 GLY E -4 REMARK 465 PHE E -3 REMARK 465 ASN E -2 REMARK 465 LYS E -1 REMARK 465 GLU E 0 REMARK 465 HIS E 1 REMARK 465 THR E 2 REMARK 465 SER E 3 REMARK 465 LYS E 4 REMARK 465 MET E 5 REMARK 465 VAL E 6 REMARK 465 SER E 7 REMARK 465 ALA E 8 REMARK 465 ILE E 9 REMARK 465 VAL E 10 REMARK 465 LEU E 11 REMARK 465 TYR E 12 REMARK 465 VAL E 13 REMARK 465 LEU E 14 REMARK 465 LEU E 15 REMARK 465 ALA E 16 REMARK 465 ALA E 17 REMARK 465 ALA E 18 REMARK 465 ALA E 19 REMARK 465 HIS E 20 REMARK 465 SER E 21 REMARK 465 ALA E 22 REMARK 465 PHE E 23 REMARK 465 ALA E 24 REMARK 465 LYS E 25 REMARK 465 THR E 26 REMARK 465 ASP E 27 REMARK 465 SER E 28 REMARK 465 SER E 29 REMARK 465 PHE E 30 REMARK 465 ILE E 31 REMARK 465 MET E 32 REMARK 465 ASP E 33 REMARK 465 GLY E 112 REMARK 465 SER E 133 REMARK 465 GLY E 134 REMARK 465 GLY E 135 REMARK 465 SER E 136 REMARK 465 GLY E 137 REMARK 465 GLY E 138 REMARK 465 SER E 139 REMARK 465 GLY E 140 REMARK 465 GLY E 141 REMARK 465 LEU E 142 REMARK 465 GLU E 143 REMARK 465 VAL E 144 REMARK 465 LEU E 145 REMARK 465 PHE E 146 REMARK 465 GLN E 147 REMARK 465 GLY E 148 REMARK 465 PRO E 149 REMARK 465 GLY E 150 REMARK 465 GLY E 151 REMARK 465 SER E 152 REMARK 465 GLY E 153 REMARK 465 GLY E 154 REMARK 465 SER E 155 REMARK 465 GLY E 156 REMARK 465 GLY E 157 REMARK 465 LYS E 158 REMARK 465 SER E 159 REMARK 465 CYS E 160 REMARK 465 ASP E 161 REMARK 465 LYS E 162 REMARK 465 THR E 163 REMARK 465 HIS E 164 REMARK 465 THR E 165 REMARK 465 CYS E 166 REMARK 465 PRO E 167 REMARK 465 PRO E 168 REMARK 465 CYS E 169 REMARK 465 PRO E 170 REMARK 465 ALA E 171 REMARK 465 PRO E 172 REMARK 465 GLU E 173 REMARK 465 LEU E 174 REMARK 465 LEU E 175 REMARK 465 GLY E 176 REMARK 465 GLY E 177 REMARK 465 PRO E 178 REMARK 465 SER E 179 REMARK 465 VAL E 180 REMARK 465 PHE E 181 REMARK 465 LEU E 182 REMARK 465 PHE E 183 REMARK 465 PRO E 184 REMARK 465 PRO E 185 REMARK 465 LYS E 186 REMARK 465 PRO E 187 REMARK 465 LYS E 188 REMARK 465 ASP E 189 REMARK 465 THR E 190 REMARK 465 LEU E 191 REMARK 465 MET E 192 REMARK 465 ILE E 193 REMARK 465 SER E 194 REMARK 465 ARG E 195 REMARK 465 THR E 196 REMARK 465 PRO E 197 REMARK 465 GLU E 198 REMARK 465 VAL E 199 REMARK 465 THR E 200 REMARK 465 CYS E 201 REMARK 465 VAL E 202 REMARK 465 VAL E 203 REMARK 465 VAL E 204 REMARK 465 ASP E 205 REMARK 465 VAL E 206 REMARK 465 SER E 207 REMARK 465 HIS E 208 REMARK 465 GLU E 209 REMARK 465 ASP E 210 REMARK 465 PRO E 211 REMARK 465 GLU E 212 REMARK 465 VAL E 213 REMARK 465 LYS E 214 REMARK 465 PHE E 215 REMARK 465 ASN E 216 REMARK 465 TRP E 217 REMARK 465 TYR E 218 REMARK 465 VAL E 219 REMARK 465 ASP E 220 REMARK 465 GLY E 221 REMARK 465 VAL E 222 REMARK 465 GLU E 223 REMARK 465 VAL E 224 REMARK 465 HIS E 225 REMARK 465 ASN E 226 REMARK 465 ALA E 227 REMARK 465 LYS E 228 REMARK 465 THR E 229 REMARK 465 LYS E 230 REMARK 465 PRO E 231 REMARK 465 ARG E 232 REMARK 465 GLU E 233 REMARK 465 GLU E 234 REMARK 465 GLN E 235 REMARK 465 TYR E 236 REMARK 465 ASN E 237 REMARK 465 SER E 238 REMARK 465 THR E 239 REMARK 465 TYR E 240 REMARK 465 ARG E 241 REMARK 465 VAL E 242 REMARK 465 VAL E 243 REMARK 465 SER E 244 REMARK 465 VAL E 245 REMARK 465 LEU E 246 REMARK 465 THR E 247 REMARK 465 VAL E 248 REMARK 465 LEU E 249 REMARK 465 HIS E 250 REMARK 465 GLN E 251 REMARK 465 ASP E 252 REMARK 465 TRP E 253 REMARK 465 LEU E 254 REMARK 465 ASN E 255 REMARK 465 GLY E 256 REMARK 465 LYS E 257 REMARK 465 GLU E 258 REMARK 465 TYR E 259 REMARK 465 LYS E 260 REMARK 465 CYS E 261 REMARK 465 LYS E 262 REMARK 465 VAL E 263 REMARK 465 SER E 264 REMARK 465 ASN E 265 REMARK 465 LYS E 266 REMARK 465 ALA E 267 REMARK 465 LEU E 268 REMARK 465 PRO E 269 REMARK 465 ALA E 270 REMARK 465 PRO E 271 REMARK 465 ILE E 272 REMARK 465 GLU E 273 REMARK 465 LYS E 274 REMARK 465 THR E 275 REMARK 465 ILE E 276 REMARK 465 SER E 277 REMARK 465 LYS E 278 REMARK 465 ALA E 279 REMARK 465 LYS E 280 REMARK 465 GLY E 281 REMARK 465 GLN E 282 REMARK 465 PRO E 283 REMARK 465 ARG E 284 REMARK 465 GLU E 285 REMARK 465 PRO E 286 REMARK 465 GLN E 287 REMARK 465 VAL E 288 REMARK 465 TYR E 289 REMARK 465 THR E 290 REMARK 465 LEU E 291 REMARK 465 PRO E 292 REMARK 465 PRO E 293 REMARK 465 SER E 294 REMARK 465 ARG E 295 REMARK 465 ASP E 296 REMARK 465 GLU E 297 REMARK 465 LEU E 298 REMARK 465 THR E 299 REMARK 465 LYS E 300 REMARK 465 ASN E 301 REMARK 465 GLN E 302 REMARK 465 VAL E 303 REMARK 465 SER E 304 REMARK 465 LEU E 305 REMARK 465 THR E 306 REMARK 465 CYS E 307 REMARK 465 LEU E 308 REMARK 465 VAL E 309 REMARK 465 LYS E 310 REMARK 465 GLY E 311 REMARK 465 PHE E 312 REMARK 465 TYR E 313 REMARK 465 PRO E 314 REMARK 465 SER E 315 REMARK 465 ASP E 316 REMARK 465 ILE E 317 REMARK 465 ALA E 318 REMARK 465 VAL E 319 REMARK 465 GLU E 320 REMARK 465 TRP E 321 REMARK 465 GLU E 322 REMARK 465 SER E 323 REMARK 465 ASN E 324 REMARK 465 GLY E 325 REMARK 465 GLN E 326 REMARK 465 PRO E 327 REMARK 465 GLU E 328 REMARK 465 ASN E 329 REMARK 465 ASN E 330 REMARK 465 TYR E 331 REMARK 465 LYS E 332 REMARK 465 ALA E 333 REMARK 465 THR E 334 REMARK 465 PRO E 335 REMARK 465 PRO E 336 REMARK 465 VAL E 337 REMARK 465 LEU E 338 REMARK 465 ASP E 339 REMARK 465 SER E 340 REMARK 465 ASP E 341 REMARK 465 GLY E 342 REMARK 465 SER E 343 REMARK 465 PHE E 344 REMARK 465 PHE E 345 REMARK 465 LEU E 346 REMARK 465 TYR E 347 REMARK 465 SER E 348 REMARK 465 LYS E 349 REMARK 465 LEU E 350 REMARK 465 THR E 351 REMARK 465 VAL E 352 REMARK 465 ASP E 353 REMARK 465 LYS E 354 REMARK 465 SER E 355 REMARK 465 ARG E 356 REMARK 465 TRP E 357 REMARK 465 GLN E 358 REMARK 465 GLN E 359 REMARK 465 GLY E 360 REMARK 465 ASN E 361 REMARK 465 VAL E 362 REMARK 465 PHE E 363 REMARK 465 SER E 364 REMARK 465 CYS E 365 REMARK 465 SER E 366 REMARK 465 VAL E 367 REMARK 465 MET E 368 REMARK 465 HIS E 369 REMARK 465 GLU E 370 REMARK 465 ALA E 371 REMARK 465 LEU E 372 REMARK 465 HIS E 373 REMARK 465 ASN E 374 REMARK 465 HIS E 375 REMARK 465 TYR E 376 REMARK 465 THR E 377 REMARK 465 GLN E 378 REMARK 465 LYS E 379 REMARK 465 SER E 380 REMARK 465 LEU E 381 REMARK 465 SER E 382 REMARK 465 LEU E 383 REMARK 465 SER E 384 REMARK 465 PRO E 385 REMARK 465 GLY E 386 REMARK 465 LYS E 387 REMARK 465 ASP E 388 REMARK 465 TYR E 389 REMARK 465 LYS E 390 REMARK 465 ASP E 391 REMARK 465 ASP E 392 REMARK 465 ASP E 393 REMARK 465 ASP E 394 REMARK 465 LYS E 395 REMARK 465 MET F -13 REMARK 465 LEU F -12 REMARK 465 LEU F -11 REMARK 465 VAL F -10 REMARK 465 ASN F -9 REMARK 465 GLN F -8 REMARK 465 SER F -7 REMARK 465 HIS F -6 REMARK 465 GLN F -5 REMARK 465 GLY F -4 REMARK 465 PHE F -3 REMARK 465 ASN F -2 REMARK 465 LYS F -1 REMARK 465 GLU F 0 REMARK 465 HIS F 1 REMARK 465 THR F 2 REMARK 465 SER F 3 REMARK 465 LYS F 4 REMARK 465 MET F 5 REMARK 465 VAL F 6 REMARK 465 SER F 7 REMARK 465 ALA F 8 REMARK 465 ILE F 9 REMARK 465 VAL F 10 REMARK 465 LEU F 11 REMARK 465 TYR F 12 REMARK 465 VAL F 13 REMARK 465 LEU F 14 REMARK 465 LEU F 15 REMARK 465 ALA F 16 REMARK 465 ALA F 17 REMARK 465 ALA F 18 REMARK 465 ALA F 19 REMARK 465 HIS F 20 REMARK 465 SER F 21 REMARK 465 ALA F 22 REMARK 465 PHE F 23 REMARK 465 ALA F 24 REMARK 465 LYS F 25 REMARK 465 THR F 26 REMARK 465 ASP F 27 REMARK 465 SER F 28 REMARK 465 SER F 29 REMARK 465 PHE F 30 REMARK 465 ILE F 31 REMARK 465 MET F 32 REMARK 465 ASP F 33 REMARK 465 SER F 34 REMARK 465 SER F 133 REMARK 465 GLY F 134 REMARK 465 GLY F 135 REMARK 465 SER F 136 REMARK 465 GLY F 137 REMARK 465 GLY F 138 REMARK 465 SER F 139 REMARK 465 GLY F 140 REMARK 465 GLY F 141 REMARK 465 LEU F 142 REMARK 465 GLU F 143 REMARK 465 VAL F 144 REMARK 465 LEU F 145 REMARK 465 PHE F 146 REMARK 465 GLN F 147 REMARK 465 GLY F 148 REMARK 465 PRO F 149 REMARK 465 GLY F 150 REMARK 465 GLY F 151 REMARK 465 SER F 152 REMARK 465 GLY F 153 REMARK 465 GLY F 154 REMARK 465 SER F 155 REMARK 465 GLY F 156 REMARK 465 GLY F 157 REMARK 465 LYS F 158 REMARK 465 SER F 159 REMARK 465 CYS F 160 REMARK 465 ASP F 161 REMARK 465 LYS F 162 REMARK 465 THR F 163 REMARK 465 HIS F 164 REMARK 465 THR F 165 REMARK 465 CYS F 166 REMARK 465 PRO F 167 REMARK 465 PRO F 168 REMARK 465 CYS F 169 REMARK 465 PRO F 170 REMARK 465 ALA F 171 REMARK 465 PRO F 172 REMARK 465 GLU F 173 REMARK 465 LEU F 174 REMARK 465 LEU F 175 REMARK 465 GLY F 176 REMARK 465 GLY F 177 REMARK 465 PRO F 178 REMARK 465 SER F 179 REMARK 465 VAL F 180 REMARK 465 PHE F 181 REMARK 465 LEU F 182 REMARK 465 PHE F 183 REMARK 465 PRO F 184 REMARK 465 PRO F 185 REMARK 465 LYS F 186 REMARK 465 PRO F 187 REMARK 465 LYS F 188 REMARK 465 ASP F 189 REMARK 465 THR F 190 REMARK 465 LEU F 191 REMARK 465 MET F 192 REMARK 465 ILE F 193 REMARK 465 SER F 194 REMARK 465 ARG F 195 REMARK 465 THR F 196 REMARK 465 PRO F 197 REMARK 465 GLU F 198 REMARK 465 VAL F 199 REMARK 465 THR F 200 REMARK 465 CYS F 201 REMARK 465 VAL F 202 REMARK 465 VAL F 203 REMARK 465 VAL F 204 REMARK 465 ASP F 205 REMARK 465 VAL F 206 REMARK 465 SER F 207 REMARK 465 HIS F 208 REMARK 465 GLU F 209 REMARK 465 ASP F 210 REMARK 465 PRO F 211 REMARK 465 GLU F 212 REMARK 465 VAL F 213 REMARK 465 LYS F 214 REMARK 465 PHE F 215 REMARK 465 ASN F 216 REMARK 465 TRP F 217 REMARK 465 TYR F 218 REMARK 465 VAL F 219 REMARK 465 ASP F 220 REMARK 465 GLY F 221 REMARK 465 VAL F 222 REMARK 465 GLU F 223 REMARK 465 VAL F 224 REMARK 465 HIS F 225 REMARK 465 ASN F 226 REMARK 465 ALA F 227 REMARK 465 LYS F 228 REMARK 465 THR F 229 REMARK 465 LYS F 230 REMARK 465 PRO F 231 REMARK 465 ARG F 232 REMARK 465 GLU F 233 REMARK 465 GLU F 234 REMARK 465 GLN F 235 REMARK 465 TYR F 236 REMARK 465 ASN F 237 REMARK 465 SER F 238 REMARK 465 THR F 239 REMARK 465 TYR F 240 REMARK 465 ARG F 241 REMARK 465 VAL F 242 REMARK 465 VAL F 243 REMARK 465 SER F 244 REMARK 465 VAL F 245 REMARK 465 LEU F 246 REMARK 465 THR F 247 REMARK 465 VAL F 248 REMARK 465 LEU F 249 REMARK 465 HIS F 250 REMARK 465 GLN F 251 REMARK 465 ASP F 252 REMARK 465 TRP F 253 REMARK 465 LEU F 254 REMARK 465 ASN F 255 REMARK 465 GLY F 256 REMARK 465 LYS F 257 REMARK 465 GLU F 258 REMARK 465 TYR F 259 REMARK 465 LYS F 260 REMARK 465 CYS F 261 REMARK 465 LYS F 262 REMARK 465 VAL F 263 REMARK 465 SER F 264 REMARK 465 ASN F 265 REMARK 465 LYS F 266 REMARK 465 ALA F 267 REMARK 465 LEU F 268 REMARK 465 PRO F 269 REMARK 465 ALA F 270 REMARK 465 PRO F 271 REMARK 465 ILE F 272 REMARK 465 GLU F 273 REMARK 465 LYS F 274 REMARK 465 THR F 275 REMARK 465 ILE F 276 REMARK 465 SER F 277 REMARK 465 LYS F 278 REMARK 465 ALA F 279 REMARK 465 LYS F 280 REMARK 465 GLY F 281 REMARK 465 GLN F 282 REMARK 465 PRO F 283 REMARK 465 ARG F 284 REMARK 465 GLU F 285 REMARK 465 PRO F 286 REMARK 465 GLN F 287 REMARK 465 VAL F 288 REMARK 465 TYR F 289 REMARK 465 THR F 290 REMARK 465 LEU F 291 REMARK 465 PRO F 292 REMARK 465 PRO F 293 REMARK 465 SER F 294 REMARK 465 ARG F 295 REMARK 465 ASP F 296 REMARK 465 GLU F 297 REMARK 465 LEU F 298 REMARK 465 THR F 299 REMARK 465 LYS F 300 REMARK 465 ASN F 301 REMARK 465 GLN F 302 REMARK 465 VAL F 303 REMARK 465 SER F 304 REMARK 465 LEU F 305 REMARK 465 THR F 306 REMARK 465 CYS F 307 REMARK 465 LEU F 308 REMARK 465 VAL F 309 REMARK 465 LYS F 310 REMARK 465 GLY F 311 REMARK 465 PHE F 312 REMARK 465 TYR F 313 REMARK 465 PRO F 314 REMARK 465 SER F 315 REMARK 465 ASP F 316 REMARK 465 ILE F 317 REMARK 465 ALA F 318 REMARK 465 VAL F 319 REMARK 465 GLU F 320 REMARK 465 TRP F 321 REMARK 465 GLU F 322 REMARK 465 SER F 323 REMARK 465 ASN F 324 REMARK 465 GLY F 325 REMARK 465 GLN F 326 REMARK 465 PRO F 327 REMARK 465 GLU F 328 REMARK 465 ASN F 329 REMARK 465 ASN F 330 REMARK 465 TYR F 331 REMARK 465 LYS F 332 REMARK 465 ALA F 333 REMARK 465 THR F 334 REMARK 465 PRO F 335 REMARK 465 PRO F 336 REMARK 465 VAL F 337 REMARK 465 LEU F 338 REMARK 465 ASP F 339 REMARK 465 SER F 340 REMARK 465 ASP F 341 REMARK 465 GLY F 342 REMARK 465 SER F 343 REMARK 465 PHE F 344 REMARK 465 PHE F 345 REMARK 465 LEU F 346 REMARK 465 TYR F 347 REMARK 465 SER F 348 REMARK 465 LYS F 349 REMARK 465 LEU F 350 REMARK 465 THR F 351 REMARK 465 VAL F 352 REMARK 465 ASP F 353 REMARK 465 LYS F 354 REMARK 465 SER F 355 REMARK 465 ARG F 356 REMARK 465 TRP F 357 REMARK 465 GLN F 358 REMARK 465 GLN F 359 REMARK 465 GLY F 360 REMARK 465 ASN F 361 REMARK 465 VAL F 362 REMARK 465 PHE F 363 REMARK 465 SER F 364 REMARK 465 CYS F 365 REMARK 465 SER F 366 REMARK 465 VAL F 367 REMARK 465 MET F 368 REMARK 465 HIS F 369 REMARK 465 GLU F 370 REMARK 465 ALA F 371 REMARK 465 LEU F 372 REMARK 465 HIS F 373 REMARK 465 ASN F 374 REMARK 465 HIS F 375 REMARK 465 TYR F 376 REMARK 465 THR F 377 REMARK 465 GLN F 378 REMARK 465 LYS F 379 REMARK 465 SER F 380 REMARK 465 LEU F 381 REMARK 465 SER F 382 REMARK 465 LEU F 383 REMARK 465 SER F 384 REMARK 465 PRO F 385 REMARK 465 GLY F 386 REMARK 465 LYS F 387 REMARK 465 ASP F 388 REMARK 465 TYR F 389 REMARK 465 LYS F 390 REMARK 465 ASP F 391 REMARK 465 ASP F 392 REMARK 465 ASP F 393 REMARK 465 ASP F 394 REMARK 465 LYS F 395 REMARK 465 MET B -18 REMARK 465 LYS B -17 REMARK 465 LYS B -16 REMARK 465 ILE B -15 REMARK 465 TRP B -14 REMARK 465 LEU B -13 REMARK 465 ALA B -12 REMARK 465 LEU B -11 REMARK 465 ALA B -10 REMARK 465 GLY B -9 REMARK 465 LEU B -8 REMARK 465 VAL B -7 REMARK 465 LEU B -6 REMARK 465 ALA B -5 REMARK 465 PHE B -4 REMARK 465 SER B -3 REMARK 465 ALA B -2 REMARK 465 SER B -1 REMARK 465 ALA B 0 REMARK 465 GLN B 1 REMARK 465 VAL B 2 REMARK 465 GLN B 3 REMARK 465 LEU B 4 REMARK 465 VAL B 5 REMARK 465 GLU B 6 REMARK 465 SER B 7 REMARK 465 GLY B 8 REMARK 465 GLY B 9 REMARK 465 GLY B 10 REMARK 465 LEU B 11 REMARK 465 VAL B 12 REMARK 465 GLN B 13 REMARK 465 THR B 14 REMARK 465 LYS B 15 REMARK 465 THR B 16 REMARK 465 THR B 17 REMARK 465 THR B 18 REMARK 465 SER B 19 REMARK 465 VAL B 20 REMARK 465 ILE B 21 REMARK 465 ASP B 22 REMARK 465 THR B 23 REMARK 465 THR B 24 REMARK 465 ASN B 25 REMARK 465 ASP B 26 REMARK 465 ALA B 27 REMARK 465 GLN B 28 REMARK 465 ASN B 29 REMARK 465 LEU B 30 REMARK 465 LEU B 31 REMARK 465 THR B 32 REMARK 465 GLN B 33 REMARK 465 ALA B 34 REMARK 465 GLN B 35 REMARK 465 THR B 36 REMARK 465 ILE B 37 REMARK 465 VAL B 38 REMARK 465 ASN B 39 REMARK 465 THR B 40 REMARK 465 LEU B 41 REMARK 465 LYS B 42 REMARK 465 ASP B 43 REMARK 465 TYR B 44 REMARK 465 CYS B 45 REMARK 465 PRO B 46 REMARK 465 ILE B 47 REMARK 465 LEU B 48 REMARK 465 ILE B 49 REMARK 465 ALA B 50 REMARK 465 LYS B 51 REMARK 465 SER B 52 REMARK 465 SER B 53 REMARK 465 SER B 54 REMARK 465 SER B 55 REMARK 465 ASN B 56 REMARK 465 GLY B 57 REMARK 465 GLY B 58 REMARK 465 THR B 59 REMARK 465 ASN B 60 REMARK 465 ASN B 61 REMARK 465 ALA B 62 REMARK 465 ASN B 63 REMARK 465 THR B 64 REMARK 465 PRO B 65 REMARK 465 SER B 66 REMARK 465 TRP B 67 REMARK 465 GLN B 68 REMARK 465 THR B 69 REMARK 465 ALA B 70 REMARK 465 GLY B 71 REMARK 465 GLY B 72 REMARK 465 GLY B 73 REMARK 465 LYS B 74 REMARK 465 ASN B 75 REMARK 465 SER B 76 REMARK 465 CYS B 77 REMARK 465 ALA B 78 REMARK 465 THR B 79 REMARK 465 PHE B 80 REMARK 465 GLY B 81 REMARK 465 ALA B 82 REMARK 465 GLU B 83 REMARK 465 PHE B 84 REMARK 465 SER B 85 REMARK 465 ALA B 86 REMARK 465 ALA B 87 REMARK 465 SER B 88 REMARK 465 ASP B 89 REMARK 465 MET B 90 REMARK 465 ILE B 91 REMARK 465 ASN B 92 REMARK 465 ASN B 93 REMARK 465 ALA B 94 REMARK 465 GLN B 95 REMARK 465 LYS B 96 REMARK 465 ILE B 97 REMARK 465 VAL B 98 REMARK 465 GLN B 99 REMARK 465 GLU B 100 REMARK 465 THR B 101 REMARK 465 GLN B 102 REMARK 465 GLN B 103 REMARK 465 LEU B 104 REMARK 465 SER B 105 REMARK 465 ALA B 106 REMARK 465 ASN B 107 REMARK 465 GLN B 108 REMARK 465 PRO B 109 REMARK 465 LYS B 110 REMARK 465 ASN B 111 REMARK 465 ILE B 112 REMARK 465 THR B 113 REMARK 465 GLN B 114 REMARK 465 PRO B 115 REMARK 465 HIS B 116 REMARK 465 ASN B 117 REMARK 465 LEU B 118 REMARK 465 ASN B 119 REMARK 465 LEU B 120 REMARK 465 ASN B 121 REMARK 465 SER B 122 REMARK 465 PRO B 123 REMARK 465 SER B 124 REMARK 465 SER B 125 REMARK 465 LEU B 126 REMARK 465 THR B 127 REMARK 465 ALA B 128 REMARK 465 LEU B 129 REMARK 465 ALA B 130 REMARK 465 GLN B 131 REMARK 465 LYS B 132 REMARK 465 MET B 133 REMARK 465 LEU B 134 REMARK 465 LYS B 135 REMARK 465 ASN B 136 REMARK 465 ALA B 137 REMARK 465 GLN B 138 REMARK 465 SER B 139 REMARK 465 GLN B 140 REMARK 465 ALA B 141 REMARK 465 GLU B 142 REMARK 465 ILE B 143 REMARK 465 LEU B 144 REMARK 465 LYS B 145 REMARK 465 LEU B 146 REMARK 465 ALA B 147 REMARK 465 ASN B 148 REMARK 465 GLN B 149 REMARK 465 VAL B 150 REMARK 465 GLU B 151 REMARK 465 SER B 152 REMARK 465 ASP B 153 REMARK 465 PHE B 154 REMARK 465 ASN B 155 REMARK 465 LYS B 156 REMARK 465 LEU B 157 REMARK 465 SER B 158 REMARK 465 SER B 159 REMARK 465 GLY B 160 REMARK 465 HIS B 161 REMARK 465 LEU B 162 REMARK 465 LYS B 163 REMARK 465 ASP B 164 REMARK 465 TYR B 165 REMARK 465 ILE B 166 REMARK 465 GLY B 167 REMARK 465 LYS B 168 REMARK 465 CYS B 169 REMARK 465 ASP B 170 REMARK 465 ALA B 171 REMARK 465 SER B 172 REMARK 465 ALA B 173 REMARK 465 ILE B 174 REMARK 465 SER B 175 REMARK 465 SER B 176 REMARK 465 ALA B 177 REMARK 465 ASN B 178 REMARK 465 MET B 179 REMARK 465 THR B 180 REMARK 465 MET B 181 REMARK 465 GLN B 182 REMARK 465 ASN B 183 REMARK 465 GLN B 184 REMARK 465 LYS B 185 REMARK 465 ASN B 186 REMARK 465 ASN B 187 REMARK 465 TRP B 188 REMARK 465 GLY B 189 REMARK 465 ASN B 190 REMARK 465 GLY B 191 REMARK 465 CYS B 192 REMARK 465 ALA B 193 REMARK 465 GLY B 194 REMARK 465 VAL B 195 REMARK 465 GLU B 196 REMARK 465 GLU B 197 REMARK 465 THR B 198 REMARK 465 GLN B 199 REMARK 465 SER B 200 REMARK 465 LEU B 201 REMARK 465 LEU B 202 REMARK 465 LYS B 203 REMARK 465 THR B 204 REMARK 465 SER B 205 REMARK 465 ALA B 206 REMARK 465 ALA B 207 REMARK 465 ASP B 208 REMARK 465 PHE B 209 REMARK 465 ASN B 210 REMARK 465 ASN B 211 REMARK 465 GLN B 212 REMARK 465 THR B 213 REMARK 465 PRO B 214 REMARK 465 GLN B 215 REMARK 465 ILE B 216 REMARK 465 ASN B 217 REMARK 465 GLN B 218 REMARK 465 ALA B 219 REMARK 465 GLN B 220 REMARK 465 ASN B 221 REMARK 465 LEU B 222 REMARK 465 ALA B 223 REMARK 465 ASN B 224 REMARK 465 THR B 225 REMARK 465 LEU B 226 REMARK 465 ILE B 227 REMARK 465 GLN B 228 REMARK 465 GLU B 229 REMARK 465 LEU B 230 REMARK 465 GLY B 231 REMARK 465 ASN B 232 REMARK 465 ASN B 233 REMARK 465 PRO B 234 REMARK 465 PHE B 235 REMARK 465 ARG B 236 REMARK 465 ALA B 237 REMARK 465 SER B 238 REMARK 465 GLY B 239 REMARK 465 GLY B 240 REMARK 465 GLY B 241 REMARK 465 SER B 242 REMARK 465 GLY B 243 REMARK 465 GLY B 244 REMARK 465 GLY B 245 REMARK 465 GLY B 246 REMARK 465 SER B 247 REMARK 465 GLY B 248 REMARK 465 LYS B 249 REMARK 465 LEU B 250 REMARK 465 SER B 251 REMARK 465 ASP B 252 REMARK 465 THR B 253 REMARK 465 TYR B 254 REMARK 465 GLU B 255 REMARK 465 GLN B 256 REMARK 465 LEU B 257 REMARK 465 SER B 258 REMARK 465 ARG B 259 REMARK 465 LEU B 260 REMARK 465 LEU B 261 REMARK 465 THR B 262 REMARK 465 ASN B 263 REMARK 465 ASP B 264 REMARK 465 ASN B 265 REMARK 465 GLY B 266 REMARK 465 THR B 267 REMARK 465 ASN B 268 REMARK 465 SER B 269 REMARK 465 LYS B 270 REMARK 465 THR B 271 REMARK 465 SER B 272 REMARK 465 ALA B 273 REMARK 465 GLN B 274 REMARK 465 ALA B 275 REMARK 465 ILE B 276 REMARK 465 ASN B 277 REMARK 465 GLN B 278 REMARK 465 ALA B 279 REMARK 465 VAL B 280 REMARK 465 ASN B 281 REMARK 465 ASN B 282 REMARK 465 LEU B 283 REMARK 465 ASN B 284 REMARK 465 GLU B 285 REMARK 465 ARG B 286 REMARK 465 ALA B 287 REMARK 465 LYS B 288 REMARK 465 THR B 289 REMARK 465 LEU B 290 REMARK 465 ALA B 291 REMARK 465 GLY B 292 REMARK 465 GLY B 293 REMARK 465 THR B 294 REMARK 465 THR B 295 REMARK 465 ASN B 296 REMARK 465 SER B 297 REMARK 465 PRO B 298 REMARK 465 ALA B 299 REMARK 465 TYR B 300 REMARK 465 GLN B 301 REMARK 465 ALA B 302 REMARK 465 THR B 303 REMARK 465 LEU B 304 REMARK 465 LEU B 305 REMARK 465 ALA B 306 REMARK 465 LEU B 307 REMARK 465 ARG B 308 REMARK 465 SER B 309 REMARK 465 VAL B 310 REMARK 465 LEU B 311 REMARK 465 GLY B 312 REMARK 465 LEU B 313 REMARK 465 TRP B 314 REMARK 465 ASN B 315 REMARK 465 SER B 316 REMARK 465 MET B 317 REMARK 465 GLY B 318 REMARK 465 TYR B 319 REMARK 465 ALA B 320 REMARK 465 VAL B 321 REMARK 465 ILE B 322 REMARK 465 CYS B 323 REMARK 465 GLY B 324 REMARK 465 GLY B 325 REMARK 465 TYR B 326 REMARK 465 THR B 327 REMARK 465 LYS B 328 REMARK 465 SER B 329 REMARK 465 PRO B 330 REMARK 465 GLY B 331 REMARK 465 GLU B 332 REMARK 465 ASN B 333 REMARK 465 ASN B 334 REMARK 465 GLN B 335 REMARK 465 LYS B 336 REMARK 465 ASP B 337 REMARK 465 PHE B 338 REMARK 465 HIS B 339 REMARK 465 TYR B 340 REMARK 465 THR B 341 REMARK 465 ASP B 342 REMARK 465 GLU B 343 REMARK 465 ASN B 344 REMARK 465 GLY B 345 REMARK 465 ASN B 346 REMARK 465 GLY B 347 REMARK 465 THR B 348 REMARK 465 THR B 349 REMARK 465 ILE B 350 REMARK 465 ASN B 351 REMARK 465 CYS B 352 REMARK 465 GLY B 353 REMARK 465 GLY B 354 REMARK 465 SER B 355 REMARK 465 THR B 356 REMARK 465 ASN B 357 REMARK 465 SER B 358 REMARK 465 ASN B 359 REMARK 465 GLY B 360 REMARK 465 THR B 361 REMARK 465 HIS B 362 REMARK 465 SER B 363 REMARK 465 TYR B 364 REMARK 465 ASN B 365 REMARK 465 GLY B 366 REMARK 465 THR B 367 REMARK 465 ASN B 368 REMARK 465 THR B 369 REMARK 465 LEU B 370 REMARK 465 LYS B 371 REMARK 465 ALA B 372 REMARK 465 ASP B 373 REMARK 465 LYS B 374 REMARK 465 ASN B 375 REMARK 465 VAL B 376 REMARK 465 SER B 377 REMARK 465 LEU B 378 REMARK 465 SER B 379 REMARK 465 ILE B 380 REMARK 465 GLU B 381 REMARK 465 GLN B 382 REMARK 465 TYR B 383 REMARK 465 GLU B 384 REMARK 465 LYS B 385 REMARK 465 ILE B 386 REMARK 465 HIS B 387 REMARK 465 GLU B 388 REMARK 465 ALA B 389 REMARK 465 TYR B 390 REMARK 465 GLN B 391 REMARK 465 ILE B 392 REMARK 465 LEU B 393 REMARK 465 SER B 394 REMARK 465 LYS B 395 REMARK 465 ALA B 396 REMARK 465 LEU B 397 REMARK 465 LYS B 398 REMARK 465 GLN B 399 REMARK 465 ALA B 400 REMARK 465 GLY B 401 REMARK 465 LEU B 402 REMARK 465 ALA B 403 REMARK 465 PRO B 404 REMARK 465 LEU B 405 REMARK 465 ASN B 406 REMARK 465 SER B 407 REMARK 465 LYS B 408 REMARK 465 GLY B 409 REMARK 465 GLU B 410 REMARK 465 LYS B 411 REMARK 465 LEU B 412 REMARK 465 GLU B 413 REMARK 465 ALA B 414 REMARK 465 HIS B 415 REMARK 465 VAL B 416 REMARK 465 THR B 417 REMARK 465 THR B 418 REMARK 465 SER B 419 REMARK 465 LYS B 420 REMARK 465 TYR B 421 REMARK 465 SER B 531 REMARK 465 HIS B 532 REMARK 465 HIS B 533 REMARK 465 HIS B 534 REMARK 465 HIS B 535 REMARK 465 HIS B 536 REMARK 465 HIS B 537 REMARK 465 MET C 9 REMARK 465 LYS C 10 REMARK 465 THR C 11 REMARK 465 ILE C 12 REMARK 465 ILE C 13 REMARK 465 ALA C 14 REMARK 465 LEU C 15 REMARK 465 SER C 16 REMARK 465 TYR C 17 REMARK 465 ILE C 18 REMARK 465 PHE C 19 REMARK 465 CYS C 20 REMARK 465 LEU C 21 REMARK 465 VAL C 22 REMARK 465 PHE C 23 REMARK 465 ALA C 24 REMARK 465 ALA C 25 REMARK 465 PRO C 26 REMARK 465 PRO C 27 REMARK 465 LEU C 28 REMARK 465 CYS C 29 REMARK 465 TRP C 474 REMARK 465 GLY C 475 REMARK 465 CYS C 476 REMARK 465 ASP C 477 REMARK 465 SER C 478 REMARK 465 TYR C 479 REMARK 465 ALA C 480 REMARK 465 ASN C 481 REMARK 465 LEU C 482 REMARK 465 ASN C 483 REMARK 465 THR C 484 REMARK 465 GLU C 485 REMARK 465 ASP C 486 REMARK 465 ASN C 487 REMARK 465 SER C 488 REMARK 465 LEU C 489 REMARK 465 GLN C 490 REMARK 465 ASP C 491 REMARK 465 HIS C 492 REMARK 465 SER C 493 REMARK 465 VAL C 494 REMARK 465 ALA C 495 REMARK 465 GLN C 496 REMARK 465 GLU C 497 REMARK 465 LYS C 498 REMARK 465 GLY C 499 REMARK 465 THR C 500 REMARK 465 ALA C 501 REMARK 465 ASP C 502 REMARK 465 ALA C 503 REMARK 465 ALA C 504 REMARK 465 ASN C 505 REMARK 465 VAL C 506 REMARK 465 THR C 507 REMARK 465 SER C 508 REMARK 465 THR C 509 REMARK 465 LEU C 510 REMARK 465 GLU C 511 REMARK 465 ASN C 512 REMARK 465 GLU C 513 REMARK 465 GLU C 514 REMARK 465 HIS C 515 REMARK 465 SER C 516 REMARK 465 GLN C 517 REMARK 465 ILE C 518 REMARK 465 ILE C 519 REMARK 465 ILE C 650 REMARK 465 MET C 651 REMARK 465 LYS C 652 REMARK 465 ASN C 653 REMARK 465 GLY C 654 REMARK 465 GLU C 733 REMARK 465 LYS C 734 REMARK 465 GLU C 735 REMARK 465 ASP C 736 REMARK 465 LEU C 737 REMARK 465 SER C 738 REMARK 465 GLU C 739 REMARK 465 ASN C 740 REMARK 465 LYS C 821 REMARK 465 LYS C 822 REMARK 465 SER C 823 REMARK 465 GLY C 824 REMARK 465 SER C 825 REMARK 465 VAL C 826 REMARK 465 SER C 827 REMARK 465 VAL C 828 REMARK 465 SER C 829 REMARK 465 ILE C 830 REMARK 465 SER C 831 REMARK 465 SER C 832 REMARK 465 GLN C 833 REMARK 465 GLY C 834 REMARK 465 GLY C 835 REMARK 465 CYS C 836 REMARK 465 LEU C 837 REMARK 465 GLU C 838 REMARK 465 GLN C 839 REMARK 465 ASP C 840 REMARK 465 PHE C 841 REMARK 465 TYR C 842 REMARK 465 TYR C 843 REMARK 465 ASP C 844 REMARK 465 CYS C 845 REMARK 465 GLY C 846 REMARK 465 MET C 847 REMARK 465 TYR C 848 REMARK 465 SER C 849 REMARK 465 HIS C 850 REMARK 465 LEU C 851 REMARK 465 GLN C 852 REMARK 465 GLY C 853 REMARK 465 ASN C 854 REMARK 465 LEU C 855 REMARK 465 THR C 856 REMARK 465 VAL C 857 REMARK 465 CYS C 858 REMARK 465 ASP C 859 REMARK 465 CYS C 860 REMARK 465 CYS C 861 REMARK 465 GLU C 862 REMARK 465 SER C 863 REMARK 465 PHE C 864 REMARK 465 LEU C 865 REMARK 465 LEU C 866 REMARK 465 THR C 867 REMARK 465 LYS C 868 REMARK 465 PRO C 869 REMARK 465 VAL C 870 REMARK 465 SER C 871 REMARK 465 CYS C 872 REMARK 465 LYS C 873 REMARK 465 HIS C 874 REMARK 465 LEU C 875 REMARK 465 ILE C 876 REMARK 465 LYS C 877 REMARK 465 SER C 878 REMARK 465 HIS C 879 REMARK 465 SER C 880 REMARK 465 CYS C 881 REMARK 465 PRO C 882 REMARK 465 ALA C 883 REMARK 465 LEU C 884 REMARK 465 ALA C 885 REMARK 465 VAL C 886 REMARK 465 ALA C 887 REMARK 465 SER C 888 REMARK 465 CYS C 889 REMARK 465 GLN C 890 REMARK 465 ARG C 891 REMARK 465 PRO C 892 REMARK 465 GLU C 893 REMARK 465 GLY C 894 REMARK 465 TYR C 895 REMARK 465 TRP C 896 REMARK 465 SER C 897 REMARK 465 ASP C 898 REMARK 465 CYS C 899 REMARK 465 GLY C 900 REMARK 465 THR C 901 REMARK 465 GLN C 902 REMARK 465 SER C 903 REMARK 465 ALA C 904 REMARK 465 HIS C 905 REMARK 465 SER C 906 REMARK 465 ASP C 907 REMARK 465 TYR C 908 REMARK 465 ALA C 909 REMARK 465 ASP C 910 REMARK 465 GLU C 911 REMARK 465 GLU C 912 REMARK 465 ASP C 913 REMARK 465 SER C 914 REMARK 465 PHE C 915 REMARK 465 VAL C 916 REMARK 465 SER C 917 REMARK 465 ASP C 918 REMARK 465 SER C 919 REMARK 465 SER C 920 REMARK 465 ASP C 921 REMARK 465 GLN C 922 REMARK 465 VAL C 923 REMARK 465 GLN C 924 REMARK 465 ALA C 925 REMARK 465 CYS C 926 REMARK 465 GLY C 927 REMARK 465 ARG C 928 REMARK 465 ALA C 929 REMARK 465 CYS C 930 REMARK 465 PHE C 931 REMARK 465 TYR C 932 REMARK 465 GLN C 933 REMARK 465 SER C 934 REMARK 465 ARG C 935 REMARK 465 GLY C 936 REMARK 465 PHE C 937 REMARK 465 PRO C 938 REMARK 465 LEU C 939 REMARK 465 VAL C 940 REMARK 465 ARG C 941 REMARK 465 TYR C 942 REMARK 465 ALA C 943 REMARK 465 TYR C 944 REMARK 465 ASN C 945 REMARK 465 LEU C 946 REMARK 465 PRO C 947 REMARK 465 ARG C 948 REMARK 465 VAL C 949 REMARK 465 LYS C 950 REMARK 465 ASP C 951 REMARK 465 ALA C 952 REMARK 465 ALA C 953 REMARK 465 ALA C 954 REMARK 465 ASP C 955 REMARK 465 TYR C 956 REMARK 465 LYS C 957 REMARK 465 ASP C 958 REMARK 465 ASP C 959 REMARK 465 ASP C 960 REMARK 465 ASP C 961 REMARK 465 LYS C 962 REMARK 465 MET D 9 REMARK 465 LYS D 10 REMARK 465 THR D 11 REMARK 465 ILE D 12 REMARK 465 ILE D 13 REMARK 465 ALA D 14 REMARK 465 LEU D 15 REMARK 465 SER D 16 REMARK 465 TYR D 17 REMARK 465 ILE D 18 REMARK 465 PHE D 19 REMARK 465 CYS D 20 REMARK 465 LEU D 21 REMARK 465 VAL D 22 REMARK 465 PHE D 23 REMARK 465 ALA D 24 REMARK 465 ALA D 25 REMARK 465 PRO D 26 REMARK 465 PRO D 27 REMARK 465 LEU D 28 REMARK 465 CYS D 29 REMARK 465 TRP D 474 REMARK 465 GLY D 475 REMARK 465 CYS D 476 REMARK 465 ASP D 477 REMARK 465 SER D 478 REMARK 465 TYR D 479 REMARK 465 ALA D 480 REMARK 465 ASN D 481 REMARK 465 LEU D 482 REMARK 465 ASN D 483 REMARK 465 THR D 484 REMARK 465 GLU D 485 REMARK 465 ASP D 486 REMARK 465 ASN D 487 REMARK 465 SER D 488 REMARK 465 LEU D 489 REMARK 465 GLN D 490 REMARK 465 ASP D 491 REMARK 465 HIS D 492 REMARK 465 SER D 493 REMARK 465 VAL D 494 REMARK 465 ALA D 495 REMARK 465 GLN D 496 REMARK 465 GLU D 497 REMARK 465 LYS D 498 REMARK 465 GLY D 499 REMARK 465 THR D 500 REMARK 465 ALA D 501 REMARK 465 ASP D 502 REMARK 465 ALA D 503 REMARK 465 ALA D 504 REMARK 465 ASN D 505 REMARK 465 VAL D 506 REMARK 465 THR D 507 REMARK 465 SER D 508 REMARK 465 THR D 509 REMARK 465 LEU D 510 REMARK 465 GLU D 511 REMARK 465 ASN D 512 REMARK 465 GLU D 513 REMARK 465 GLU D 514 REMARK 465 HIS D 515 REMARK 465 SER D 516 REMARK 465 GLN D 517 REMARK 465 ILE D 518 REMARK 465 ILE D 519 REMARK 465 ILE D 520 REMARK 465 HIS D 521 REMARK 465 CYS D 522 REMARK 465 THR D 523 REMARK 465 PRO D 524 REMARK 465 SER D 525 REMARK 465 THR D 526 REMARK 465 ILE D 650 REMARK 465 MET D 651 REMARK 465 LYS D 652 REMARK 465 ASN D 653 REMARK 465 GLY D 654 REMARK 465 GLU D 733 REMARK 465 LYS D 734 REMARK 465 GLU D 735 REMARK 465 ASP D 736 REMARK 465 LEU D 737 REMARK 465 SER D 738 REMARK 465 GLU D 739 REMARK 465 ASN D 740 REMARK 465 LYS D 821 REMARK 465 LYS D 822 REMARK 465 SER D 823 REMARK 465 GLY D 824 REMARK 465 SER D 825 REMARK 465 VAL D 826 REMARK 465 SER D 827 REMARK 465 VAL D 828 REMARK 465 SER D 829 REMARK 465 ILE D 830 REMARK 465 SER D 831 REMARK 465 SER D 832 REMARK 465 GLN D 833 REMARK 465 GLY D 834 REMARK 465 GLY D 835 REMARK 465 CYS D 836 REMARK 465 LEU D 837 REMARK 465 GLU D 838 REMARK 465 GLN D 839 REMARK 465 ASP D 840 REMARK 465 PHE D 841 REMARK 465 TYR D 842 REMARK 465 TYR D 843 REMARK 465 ASP D 844 REMARK 465 CYS D 845 REMARK 465 GLY D 846 REMARK 465 MET D 847 REMARK 465 TYR D 848 REMARK 465 SER D 849 REMARK 465 HIS D 850 REMARK 465 LEU D 851 REMARK 465 GLN D 852 REMARK 465 GLY D 853 REMARK 465 ASN D 854 REMARK 465 LEU D 855 REMARK 465 THR D 856 REMARK 465 VAL D 857 REMARK 465 CYS D 858 REMARK 465 ASP D 859 REMARK 465 CYS D 860 REMARK 465 CYS D 861 REMARK 465 GLU D 862 REMARK 465 SER D 863 REMARK 465 PHE D 864 REMARK 465 LEU D 865 REMARK 465 LEU D 866 REMARK 465 THR D 867 REMARK 465 LYS D 868 REMARK 465 PRO D 869 REMARK 465 VAL D 870 REMARK 465 SER D 871 REMARK 465 CYS D 872 REMARK 465 LYS D 873 REMARK 465 HIS D 874 REMARK 465 LEU D 875 REMARK 465 ILE D 876 REMARK 465 LYS D 877 REMARK 465 SER D 878 REMARK 465 HIS D 879 REMARK 465 SER D 880 REMARK 465 CYS D 881 REMARK 465 PRO D 882 REMARK 465 ALA D 883 REMARK 465 LEU D 884 REMARK 465 ALA D 885 REMARK 465 VAL D 886 REMARK 465 ALA D 887 REMARK 465 SER D 888 REMARK 465 CYS D 889 REMARK 465 GLN D 890 REMARK 465 ARG D 891 REMARK 465 PRO D 892 REMARK 465 GLU D 893 REMARK 465 GLY D 894 REMARK 465 TYR D 895 REMARK 465 TRP D 896 REMARK 465 SER D 897 REMARK 465 ASP D 898 REMARK 465 CYS D 899 REMARK 465 GLY D 900 REMARK 465 THR D 901 REMARK 465 GLN D 902 REMARK 465 SER D 903 REMARK 465 ALA D 904 REMARK 465 HIS D 905 REMARK 465 SER D 906 REMARK 465 ASP D 907 REMARK 465 TYR D 908 REMARK 465 ALA D 909 REMARK 465 ASP D 910 REMARK 465 GLU D 911 REMARK 465 GLU D 912 REMARK 465 ASP D 913 REMARK 465 SER D 914 REMARK 465 PHE D 915 REMARK 465 VAL D 916 REMARK 465 SER D 917 REMARK 465 ASP D 918 REMARK 465 SER D 919 REMARK 465 SER D 920 REMARK 465 ASP D 921 REMARK 465 GLN D 922 REMARK 465 VAL D 923 REMARK 465 GLN D 924 REMARK 465 ALA D 925 REMARK 465 CYS D 926 REMARK 465 GLY D 927 REMARK 465 ARG D 928 REMARK 465 ALA D 929 REMARK 465 CYS D 930 REMARK 465 PHE D 931 REMARK 465 TYR D 932 REMARK 465 GLN D 933 REMARK 465 SER D 934 REMARK 465 ARG D 935 REMARK 465 GLY D 936 REMARK 465 PHE D 937 REMARK 465 PRO D 938 REMARK 465 LEU D 939 REMARK 465 VAL D 940 REMARK 465 ARG D 941 REMARK 465 TYR D 942 REMARK 465 ALA D 943 REMARK 465 TYR D 944 REMARK 465 ASN D 945 REMARK 465 LEU D 946 REMARK 465 PRO D 947 REMARK 465 ARG D 948 REMARK 465 VAL D 949 REMARK 465 LYS D 950 REMARK 465 ASP D 951 REMARK 465 ALA D 952 REMARK 465 ALA D 953 REMARK 465 ALA D 954 REMARK 465 ASP D 955 REMARK 465 TYR D 956 REMARK 465 LYS D 957 REMARK 465 ASP D 958 REMARK 465 ASP D 959 REMARK 465 ASP D 960 REMARK 465 ASP D 961 REMARK 465 LYS D 962 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ARG C 460 CG CD NE CZ NH1 NH2 REMARK 470 TYR C 466 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 TYR C 468 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ILE C 520 CB CG1 CG2 CD1 REMARK 470 HIS C 521 CB CG ND1 CD2 CE1 NE2 REMARK 470 CYS C 522 CB SG REMARK 470 THR C 523 CB OG1 CG2 REMARK 470 PRO C 524 CB CG CD REMARK 470 SER C 525 CB OG REMARK 470 THR C 526 CB OG1 CG2 REMARK 470 ALA C 528 CB REMARK 470 PHE C 529 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LYS C 530 CB CG CD CE NZ REMARK 470 PRO C 531 CB CG CD REMARK 470 CYS C 532 CB SG REMARK 470 GLU C 533 CB CG CD OE1 OE2 REMARK 470 TYR C 534 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR C 534 OH REMARK 470 LEU C 535 CB CG CD1 CD2 REMARK 470 LEU C 536 CB CG CD1 CD2 REMARK 470 SER C 538 CB OG REMARK 470 TRP C 539 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP C 539 CZ2 CZ3 CH2 REMARK 470 MET C 540 CB CG SD CE REMARK 470 ILE C 541 CB CG1 CG2 CD1 REMARK 470 ARG C 542 CB CG CD NE CZ NH1 NH2 REMARK 470 LEU C 543 CB CG CD1 CD2 REMARK 470 THR C 544 CB OG1 CG2 REMARK 470 VAL C 545 CB CG1 CG2 REMARK 470 TRP C 546 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP C 546 CZ2 CZ3 CH2 REMARK 470 PHE C 547 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ILE C 548 CB CG1 CG2 CD1 REMARK 470 PHE C 549 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU C 550 CB CG CD1 CD2 REMARK 470 VAL C 551 CB CG1 CG2 REMARK 470 ALA C 552 CB REMARK 470 LEU C 553 CB CG CD1 CD2 REMARK 470 PHE C 554 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE C 555 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ASN C 556 CB CG OD1 ND2 REMARK 470 LEU C 557 CB CG CD1 CD2 REMARK 470 LEU C 558 CB CG CD1 CD2 REMARK 470 VAL C 559 CB CG1 CG2 REMARK 470 ILE C 560 CB CG1 CG2 CD1 REMARK 470 LEU C 561 CB CG CD1 CD2 REMARK 470 THR C 562 CB OG1 CG2 REMARK 470 THR C 563 CB OG1 CG2 REMARK 470 PHE C 564 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ALA C 565 CB REMARK 470 SER C 566 CB OG REMARK 470 CYS C 567 CB SG REMARK 470 THR C 568 CB OG1 CG2 REMARK 470 SER C 569 CB OG REMARK 470 LEU C 570 CB CG CD1 CD2 REMARK 470 PRO C 571 CB CG CD REMARK 470 SER C 572 CB OG REMARK 470 SER C 573 CB OG REMARK 470 LYS C 574 CB CG CD CE NZ REMARK 470 LEU C 575 CB CG CD1 CD2 REMARK 470 PHE C 576 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ILE C 577 CB CG1 CG2 CD1 REMARK 470 LEU C 579 CB CG CD1 CD2 REMARK 470 ILE C 580 CB CG1 CG2 CD1 REMARK 470 SER C 581 CB OG REMARK 470 VAL C 582 CB CG1 CG2 REMARK 470 SER C 583 CB OG REMARK 470 ASN C 584 CB CG OD1 ND2 REMARK 470 LEU C 585 CB CG CD1 CD2 REMARK 470 PHE C 586 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 MET C 587 CB CG SD CE REMARK 470 ILE C 589 CB CG1 CG2 CD1 REMARK 470 TYR C 590 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR C 590 OH REMARK 470 THR C 591 CB OG1 CG2 REMARK 470 ILE C 593 CB CG1 CG2 CD1 REMARK 470 LEU C 594 CB CG CD1 CD2 REMARK 470 THR C 595 CB OG1 CG2 REMARK 470 PHE C 596 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU C 597 CB CG CD1 CD2 REMARK 470 ASP C 598 CB CG OD1 OD2 REMARK 470 ALA C 599 CB REMARK 470 VAL C 600 CB CG1 CG2 REMARK 470 SER C 601 CB OG REMARK 470 TRP C 602 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP C 602 CZ2 CZ3 CH2 REMARK 470 ARG C 604 CB CG CD NE CZ NH1 NH2 REMARK 470 PHE C 605 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ALA C 606 CB REMARK 470 GLU C 607 CB CG CD OE1 OE2 REMARK 470 PHE C 608 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ILE C 610 CB CG1 CG2 CD1 REMARK 470 TRP C 611 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP C 611 CZ2 CZ3 CH2 REMARK 470 TRP C 612 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP C 612 CZ2 CZ3 CH2 REMARK 470 GLU C 613 CB CG CD OE1 OE2 REMARK 470 THR C 614 CB OG1 CG2 REMARK 470 SER C 616 CB OG REMARK 470 CYS C 618 CB SG REMARK 470 LYS C 619 CB CG CD CE NZ REMARK 470 VAL C 620 CB CG1 CG2 REMARK 470 ALA C 621 CB REMARK 470 PHE C 623 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU C 624 CB CG CD1 CD2 REMARK 470 ALA C 625 CB REMARK 470 VAL C 626 CB CG1 CG2 REMARK 470 PHE C 627 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 SER C 628 CB OG REMARK 470 SER C 629 CB OG REMARK 470 GLU C 630 CB CG CD OE1 OE2 REMARK 470 SER C 631 CB OG REMARK 470 ALA C 632 CB REMARK 470 ILE C 633 CB CG1 CG2 CD1 REMARK 470 PHE C 634 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU C 635 CB CG CD1 CD2 REMARK 470 LEU C 636 CB CG CD1 CD2 REMARK 470 MET C 637 CB CG SD CE REMARK 470 LEU C 638 CB CG CD1 CD2 REMARK 470 ALA C 639 CB REMARK 470 THR C 640 CB OG1 CG2 REMARK 470 VAL C 641 CB CG1 CG2 REMARK 470 GLU C 642 CB CG CD OE1 OE2 REMARK 470 ARG C 643 CB CG CD NE CZ NH1 NH2 REMARK 470 SER C 644 CB OG REMARK 470 LEU C 645 CB CG CD1 CD2 REMARK 470 SER C 646 CB OG REMARK 470 ALA C 647 CB REMARK 470 LYS C 648 CB CG CD CE NZ REMARK 470 ASP C 649 CB CG OD1 OD2 REMARK 470 LYS C 655 CB CG CD CE NZ REMARK 470 SER C 656 CB OG REMARK 470 ASN C 657 CB CG OD1 ND2 REMARK 470 HIS C 658 CB CG ND1 CD2 CE1 NE2 REMARK 470 LEU C 659 CB CG CD1 CD2 REMARK 470 LYS C 660 CB CG CD CE NZ REMARK 470 GLN C 661 CB CG CD OE1 NE2 REMARK 470 PHE C 662 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ARG C 663 CB CG CD NE CZ NH1 NH2 REMARK 470 VAL C 664 CB CG1 CG2 REMARK 470 ALA C 665 CB REMARK 470 ALA C 666 CB REMARK 470 LEU C 667 CB CG CD1 CD2 REMARK 470 LEU C 668 CB CG CD1 CD2 REMARK 470 ALA C 669 CB REMARK 470 PHE C 670 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU C 671 CB CG CD1 CD2 REMARK 470 ALA C 673 CB REMARK 470 THR C 674 CB OG1 CG2 REMARK 470 VAL C 675 CB CG1 CG2 REMARK 470 ALA C 676 CB REMARK 470 CYS C 678 CB SG REMARK 470 PHE C 679 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PRO C 680 CB CG CD REMARK 470 LEU C 681 CB CG CD1 CD2 REMARK 470 PHE C 682 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 HIS C 683 CB CG ND1 CD2 CE1 NE2 REMARK 470 ARG C 684 CB CG CD NE CZ NH1 NH2 REMARK 470 GLU C 686 CB CG CD OE1 OE2 REMARK 470 TYR C 687 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR C 687 OH REMARK 470 SER C 688 CB OG REMARK 470 ALA C 689 CB REMARK 470 SER C 690 CB OG REMARK 470 PRO C 691 CB CG CD REMARK 470 LEU C 692 CB CG CD1 CD2 REMARK 470 CYS C 693 CB SG REMARK 470 LEU C 694 CB CG CD1 CD2 REMARK 470 PRO C 695 CB CG CD REMARK 470 PHE C 696 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PRO C 697 CB CG CD REMARK 470 THR C 698 CB OG1 CG2 REMARK 470 GLU C 700 CB CG CD OE1 OE2 REMARK 470 THR C 701 CB OG1 CG2 REMARK 470 PRO C 702 CB CG CD REMARK 470 SER C 703 CB OG REMARK 470 LEU C 704 CB CG CD1 CD2 REMARK 470 PHE C 706 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR C 707 CB OG1 CG2 REMARK 470 VAL C 708 CB CG1 CG2 REMARK 470 THR C 709 CB OG1 CG2 REMARK 470 LEU C 710 CB CG CD1 CD2 REMARK 470 VAL C 711 CB CG1 CG2 REMARK 470 LEU C 712 CB CG CD1 CD2 REMARK 470 LEU C 713 CB CG CD1 CD2 REMARK 470 ASN C 714 CB CG OD1 ND2 REMARK 470 SER C 715 CB OG REMARK 470 LEU C 716 CB CG CD1 CD2 REMARK 470 ALA C 717 CB REMARK 470 PHE C 718 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU C 719 CB CG CD1 CD2 REMARK 470 LEU C 720 CB CG CD1 CD2 REMARK 470 MET C 721 CB CG SD CE REMARK 470 ALA C 722 CB REMARK 470 VAL C 723 CB CG1 CG2 REMARK 470 ILE C 724 CB CG1 CG2 CD1 REMARK 470 TYR C 725 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR C 725 OH REMARK 470 THR C 726 CB OG1 CG2 REMARK 470 LYS C 727 CB CG CD CE NZ REMARK 470 LEU C 728 CB CG CD1 CD2 REMARK 470 TYR C 729 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR C 729 OH REMARK 470 CYS C 730 CB SG REMARK 470 ASN C 731 CB CG OD1 ND2 REMARK 470 LEU C 732 CB CG CD1 CD2 REMARK 470 SER C 741 CB OG REMARK 470 GLN C 742 CB CG CD OE1 NE2 REMARK 470 SER C 743 CB OG REMARK 470 SER C 744 CB OG REMARK 470 MET C 745 CB CG SD CE REMARK 470 ILE C 746 CB CG1 CG2 CD1 REMARK 470 LYS C 747 CB CG CD CE NZ REMARK 470 HIS C 748 CB CG ND1 CD2 CE1 NE2 REMARK 470 VAL C 749 CB CG1 CG2 REMARK 470 ALA C 750 CB REMARK 470 TRP C 751 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP C 751 CZ2 CZ3 CH2 REMARK 470 LEU C 752 CB CG CD1 CD2 REMARK 470 ILE C 753 CB CG1 CG2 CD1 REMARK 470 PHE C 754 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR C 755 CB OG1 CG2 REMARK 470 ASN C 756 CB CG OD1 ND2 REMARK 470 CYS C 757 CB SG REMARK 470 ILE C 758 CB CG1 CG2 CD1 REMARK 470 PHE C 759 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE C 760 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 CYS C 761 CB SG REMARK 470 PRO C 762 CB CG CD REMARK 470 VAL C 763 CB CG1 CG2 REMARK 470 ALA C 764 CB REMARK 470 PHE C 765 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE C 766 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 SER C 767 CB OG REMARK 470 PHE C 768 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ALA C 769 CB REMARK 470 PRO C 770 CB CG CD REMARK 470 LEU C 771 CB CG CD1 CD2 REMARK 470 ILE C 772 CB CG1 CG2 CD1 REMARK 470 THR C 773 CB OG1 CG2 REMARK 470 ALA C 774 CB REMARK 470 ILE C 775 CB CG1 CG2 CD1 REMARK 470 SER C 776 CB OG REMARK 470 ILE C 777 CB CG1 CG2 CD1 REMARK 470 SER C 778 CB OG REMARK 470 PRO C 779 CB CG CD REMARK 470 GLU C 780 CB CG CD OE1 OE2 REMARK 470 ILE C 781 CB CG1 CG2 CD1 REMARK 470 MET C 782 CB CG SD CE REMARK 470 LYS C 783 CB CG CD CE NZ REMARK 470 SER C 784 CB OG REMARK 470 VAL C 785 CB CG1 CG2 REMARK 470 THR C 786 CB OG1 CG2 REMARK 470 LEU C 787 CB CG CD1 CD2 REMARK 470 ILE C 788 CB CG1 CG2 CD1 REMARK 470 PHE C 789 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE C 790 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PRO C 791 CB CG CD REMARK 470 LEU C 792 CB CG CD1 CD2 REMARK 470 PRO C 793 CB CG CD REMARK 470 ALA C 794 CB REMARK 470 CYS C 795 CB SG REMARK 470 LEU C 796 CB CG CD1 CD2 REMARK 470 ASN C 797 CB CG OD1 ND2 REMARK 470 PRO C 798 CB CG CD REMARK 470 VAL C 799 CB CG1 CG2 REMARK 470 LEU C 800 CB CG CD1 CD2 REMARK 470 TYR C 801 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR C 801 OH REMARK 470 VAL C 802 CB CG1 CG2 REMARK 470 PHE C 803 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE C 804 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ASN C 805 CB CG OD1 ND2 REMARK 470 PRO C 806 CB CG CD REMARK 470 LYS C 807 CB CG CD CE NZ REMARK 470 PHE C 808 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LYS C 809 CB CG CD CE NZ REMARK 470 GLU C 810 CB CG CD OE1 OE2 REMARK 470 ASP C 811 CB CG OD1 OD2 REMARK 470 TRP C 812 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP C 812 CZ2 CZ3 CH2 REMARK 470 LYS C 813 CB CG CD CE NZ REMARK 470 LEU C 814 CB CG CD1 CD2 REMARK 470 LEU C 815 CB CG CD1 CD2 REMARK 470 LYS C 816 CB CG CD CE NZ REMARK 470 ARG C 817 CB CG CD NE CZ NH1 NH2 REMARK 470 ARG C 818 CB CG CD NE CZ NH1 NH2 REMARK 470 VAL C 819 CB CG1 CG2 REMARK 470 THR C 820 CB OG1 CG2 REMARK 470 TYR D 466 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 TYR D 468 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ALA D 528 CB REMARK 470 PHE D 529 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LYS D 530 CB CG CD CE NZ REMARK 470 PRO D 531 CB CG CD REMARK 470 CYS D 532 CB SG REMARK 470 GLU D 533 CB CG CD OE1 OE2 REMARK 470 TYR D 534 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR D 534 OH REMARK 470 LEU D 535 CB CG CD1 CD2 REMARK 470 LEU D 536 CB CG CD1 CD2 REMARK 470 SER D 538 CB OG REMARK 470 TRP D 539 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP D 539 CZ2 CZ3 CH2 REMARK 470 MET D 540 CB CG SD CE REMARK 470 ILE D 541 CB CG1 CG2 CD1 REMARK 470 ARG D 542 CB CG CD NE CZ NH1 NH2 REMARK 470 LEU D 543 CB CG CD1 CD2 REMARK 470 THR D 544 CB OG1 CG2 REMARK 470 VAL D 545 CB CG1 CG2 REMARK 470 TRP D 546 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP D 546 CZ2 CZ3 CH2 REMARK 470 PHE D 547 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ILE D 548 CB CG1 CG2 CD1 REMARK 470 PHE D 549 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU D 550 CB CG CD1 CD2 REMARK 470 VAL D 551 CB CG1 CG2 REMARK 470 ALA D 552 CB REMARK 470 LEU D 553 CB CG CD1 CD2 REMARK 470 PHE D 554 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE D 555 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ASN D 556 CB CG OD1 ND2 REMARK 470 LEU D 557 CB CG CD1 CD2 REMARK 470 LEU D 558 CB CG CD1 CD2 REMARK 470 VAL D 559 CB CG1 CG2 REMARK 470 ILE D 560 CB CG1 CG2 CD1 REMARK 470 LEU D 561 CB CG CD1 CD2 REMARK 470 THR D 562 CB OG1 CG2 REMARK 470 THR D 563 CB OG1 CG2 REMARK 470 PHE D 564 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ALA D 565 CB REMARK 470 SER D 566 CB OG REMARK 470 CYS D 567 CB SG REMARK 470 THR D 568 CB OG1 CG2 REMARK 470 SER D 569 CB OG REMARK 470 LEU D 570 CB CG CD1 CD2 REMARK 470 PRO D 571 CB CG CD REMARK 470 SER D 572 CB OG REMARK 470 SER D 573 CB OG REMARK 470 LYS D 574 CB CG CD CE NZ REMARK 470 LEU D 575 CB CG CD1 CD2 REMARK 470 PHE D 576 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ILE D 577 CB CG1 CG2 CD1 REMARK 470 LEU D 579 CB CG CD1 CD2 REMARK 470 ILE D 580 CB CG1 CG2 CD1 REMARK 470 SER D 581 CB OG REMARK 470 VAL D 582 CB CG1 CG2 REMARK 470 SER D 583 CB OG REMARK 470 ASN D 584 CB CG OD1 ND2 REMARK 470 LEU D 585 CB CG CD1 CD2 REMARK 470 PHE D 586 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 MET D 587 CB CG SD CE REMARK 470 ILE D 589 CB CG1 CG2 CD1 REMARK 470 TYR D 590 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR D 590 OH REMARK 470 THR D 591 CB OG1 CG2 REMARK 470 ILE D 593 CB CG1 CG2 CD1 REMARK 470 LEU D 594 CB CG CD1 CD2 REMARK 470 THR D 595 CB OG1 CG2 REMARK 470 PHE D 596 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU D 597 CB CG CD1 CD2 REMARK 470 ASP D 598 CB CG OD1 OD2 REMARK 470 ALA D 599 CB REMARK 470 VAL D 600 CB CG1 CG2 REMARK 470 SER D 601 CB OG REMARK 470 TRP D 602 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP D 602 CZ2 CZ3 CH2 REMARK 470 ARG D 604 CB CG CD NE CZ NH1 NH2 REMARK 470 PHE D 605 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ALA D 606 CB REMARK 470 GLU D 607 CB CG CD OE1 OE2 REMARK 470 PHE D 608 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ILE D 610 CB CG1 CG2 CD1 REMARK 470 TRP D 611 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP D 611 CZ2 CZ3 CH2 REMARK 470 TRP D 612 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP D 612 CZ2 CZ3 CH2 REMARK 470 GLU D 613 CB CG CD OE1 OE2 REMARK 470 THR D 614 CB OG1 CG2 REMARK 470 SER D 616 CB OG REMARK 470 CYS D 618 CB SG REMARK 470 LYS D 619 CB CG CD CE NZ REMARK 470 VAL D 620 CB CG1 CG2 REMARK 470 ALA D 621 CB REMARK 470 PHE D 623 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU D 624 CB CG CD1 CD2 REMARK 470 ALA D 625 CB REMARK 470 VAL D 626 CB CG1 CG2 REMARK 470 PHE D 627 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 SER D 628 CB OG REMARK 470 SER D 629 CB OG REMARK 470 GLU D 630 CB CG CD OE1 OE2 REMARK 470 SER D 631 CB OG REMARK 470 ALA D 632 CB REMARK 470 ILE D 633 CB CG1 CG2 CD1 REMARK 470 PHE D 634 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU D 635 CB CG CD1 CD2 REMARK 470 LEU D 636 CB CG CD1 CD2 REMARK 470 MET D 637 CB CG SD CE REMARK 470 LEU D 638 CB CG CD1 CD2 REMARK 470 ALA D 639 CB REMARK 470 THR D 640 CB OG1 CG2 REMARK 470 VAL D 641 CB CG1 CG2 REMARK 470 GLU D 642 CB CG CD OE1 OE2 REMARK 470 ARG D 643 CB CG CD NE CZ NH1 NH2 REMARK 470 SER D 644 CB OG REMARK 470 LEU D 645 CB CG CD1 CD2 REMARK 470 SER D 646 CB OG REMARK 470 ALA D 647 CB REMARK 470 LYS D 648 CB CG CD CE NZ REMARK 470 ASP D 649 CB CG OD1 OD2 REMARK 470 LYS D 655 CB CG CD CE NZ REMARK 470 SER D 656 CB OG REMARK 470 ASN D 657 CB CG OD1 ND2 REMARK 470 HIS D 658 CB CG ND1 CD2 CE1 NE2 REMARK 470 LEU D 659 CB CG CD1 CD2 REMARK 470 LYS D 660 CB CG CD CE NZ REMARK 470 GLN D 661 CB CG CD OE1 NE2 REMARK 470 PHE D 662 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ARG D 663 CB CG CD NE CZ NH1 NH2 REMARK 470 VAL D 664 CB CG1 CG2 REMARK 470 ALA D 665 CB REMARK 470 ALA D 666 CB REMARK 470 LEU D 667 CB CG CD1 CD2 REMARK 470 LEU D 668 CB CG CD1 CD2 REMARK 470 ALA D 669 CB REMARK 470 PHE D 670 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU D 671 CB CG CD1 CD2 REMARK 470 ALA D 673 CB REMARK 470 THR D 674 CB OG1 CG2 REMARK 470 VAL D 675 CB CG1 CG2 REMARK 470 ALA D 676 CB REMARK 470 CYS D 678 CB SG REMARK 470 PHE D 679 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PRO D 680 CB CG CD REMARK 470 LEU D 681 CB CG CD1 CD2 REMARK 470 PHE D 682 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 HIS D 683 CB CG ND1 CD2 CE1 NE2 REMARK 470 ARG D 684 CB CG CD NE CZ NH1 NH2 REMARK 470 GLU D 686 CB CG CD OE1 OE2 REMARK 470 TYR D 687 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR D 687 OH REMARK 470 SER D 688 CB OG REMARK 470 ALA D 689 CB REMARK 470 SER D 690 CB OG REMARK 470 PRO D 691 CB CG CD REMARK 470 LEU D 692 CB CG CD1 CD2 REMARK 470 CYS D 693 CB SG REMARK 470 LEU D 694 CB CG CD1 CD2 REMARK 470 PRO D 695 CB CG CD REMARK 470 PHE D 696 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PRO D 697 CB CG CD REMARK 470 THR D 698 CB OG1 CG2 REMARK 470 GLU D 700 CB CG CD OE1 OE2 REMARK 470 THR D 701 CB OG1 CG2 REMARK 470 PRO D 702 CB CG CD REMARK 470 SER D 703 CB OG REMARK 470 LEU D 704 CB CG CD1 CD2 REMARK 470 PHE D 706 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR D 707 CB OG1 CG2 REMARK 470 VAL D 708 CB CG1 CG2 REMARK 470 THR D 709 CB OG1 CG2 REMARK 470 LEU D 710 CB CG CD1 CD2 REMARK 470 VAL D 711 CB CG1 CG2 REMARK 470 LEU D 712 CB CG CD1 CD2 REMARK 470 LEU D 713 CB CG CD1 CD2 REMARK 470 ASN D 714 CB CG OD1 ND2 REMARK 470 SER D 715 CB OG REMARK 470 LEU D 716 CB CG CD1 CD2 REMARK 470 ALA D 717 CB REMARK 470 PHE D 718 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU D 719 CB CG CD1 CD2 REMARK 470 LEU D 720 CB CG CD1 CD2 REMARK 470 MET D 721 CB CG SD CE REMARK 470 ALA D 722 CB REMARK 470 VAL D 723 CB CG1 CG2 REMARK 470 ILE D 724 CB CG1 CG2 CD1 REMARK 470 TYR D 725 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR D 725 OH REMARK 470 THR D 726 CB OG1 CG2 REMARK 470 LYS D 727 CB CG CD CE NZ REMARK 470 LEU D 728 CB CG CD1 CD2 REMARK 470 TYR D 729 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR D 729 OH REMARK 470 CYS D 730 CB SG REMARK 470 ASN D 731 CB CG OD1 ND2 REMARK 470 LEU D 732 CB CG CD1 CD2 REMARK 470 SER D 741 CB OG REMARK 470 GLN D 742 CB CG CD OE1 NE2 REMARK 470 SER D 743 CB OG REMARK 470 SER D 744 CB OG REMARK 470 MET D 745 CB CG SD CE REMARK 470 ILE D 746 CB CG1 CG2 CD1 REMARK 470 LYS D 747 CB CG CD CE NZ REMARK 470 HIS D 748 CB CG ND1 CD2 CE1 NE2 REMARK 470 VAL D 749 CB CG1 CG2 REMARK 470 ALA D 750 CB REMARK 470 TRP D 751 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP D 751 CZ2 CZ3 CH2 REMARK 470 LEU D 752 CB CG CD1 CD2 REMARK 470 ILE D 753 CB CG1 CG2 CD1 REMARK 470 PHE D 754 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 THR D 755 CB OG1 CG2 REMARK 470 ASN D 756 CB CG OD1 ND2 REMARK 470 CYS D 757 CB SG REMARK 470 ILE D 758 CB CG1 CG2 CD1 REMARK 470 PHE D 759 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE D 760 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 CYS D 761 CB SG REMARK 470 PRO D 762 CB CG CD REMARK 470 VAL D 763 CB CG1 CG2 REMARK 470 ALA D 764 CB REMARK 470 PHE D 765 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE D 766 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 SER D 767 CB OG REMARK 470 PHE D 768 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ALA D 769 CB REMARK 470 PRO D 770 CB CG CD REMARK 470 LEU D 771 CB CG CD1 CD2 REMARK 470 ILE D 772 CB CG1 CG2 CD1 REMARK 470 THR D 773 CB OG1 CG2 REMARK 470 ALA D 774 CB REMARK 470 ILE D 775 CB CG1 CG2 CD1 REMARK 470 SER D 776 CB OG REMARK 470 ILE D 777 CB CG1 CG2 CD1 REMARK 470 SER D 778 CB OG REMARK 470 PRO D 779 CB CG CD REMARK 470 GLU D 780 CB CG CD OE1 OE2 REMARK 470 ILE D 781 CB CG1 CG2 CD1 REMARK 470 MET D 782 CB CG SD CE REMARK 470 LYS D 783 CB CG CD CE NZ REMARK 470 SER D 784 CB OG REMARK 470 VAL D 785 CB CG1 CG2 REMARK 470 THR D 786 CB OG1 CG2 REMARK 470 LEU D 787 CB CG CD1 CD2 REMARK 470 ILE D 788 CB CG1 CG2 CD1 REMARK 470 PHE D 789 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE D 790 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PRO D 791 CB CG CD REMARK 470 LEU D 792 CB CG CD1 CD2 REMARK 470 PRO D 793 CB CG CD REMARK 470 ALA D 794 CB REMARK 470 CYS D 795 CB SG REMARK 470 LEU D 796 CB CG CD1 CD2 REMARK 470 ASN D 797 CB CG OD1 ND2 REMARK 470 PRO D 798 CB CG CD REMARK 470 VAL D 799 CB CG1 CG2 REMARK 470 LEU D 800 CB CG CD1 CD2 REMARK 470 TYR D 801 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR D 801 OH REMARK 470 VAL D 802 CB CG1 CG2 REMARK 470 PHE D 803 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 PHE D 804 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 ASN D 805 CB CG OD1 ND2 REMARK 470 PRO D 806 CB CG CD REMARK 470 LYS D 807 CB CG CD CE NZ REMARK 470 PHE D 808 CB CG CD1 CD2 CE1 CE2 CZ REMARK 470 LYS D 809 CB CG CD CE NZ REMARK 470 GLU D 810 CB CG CD OE1 OE2 REMARK 470 ASP D 811 CB CG OD1 OD2 REMARK 470 TRP D 812 CB CG CD1 CD2 NE1 CE2 CE3 REMARK 470 TRP D 812 CZ2 CZ3 CH2 REMARK 470 LYS D 813 CB CG CD CE NZ REMARK 470 LEU D 814 CB CG CD1 CD2 REMARK 470 LEU D 815 CB CG CD1 CD2 REMARK 470 LYS D 816 CB CG CD CE NZ REMARK 470 ARG D 817 CB CG CD NE CZ NH1 NH2 REMARK 470 ARG D 818 CB CG CD NE CZ NH1 NH2 REMARK 470 VAL D 819 CB CG1 CG2 REMARK 470 THR D 820 CB OG1 CG2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 SD MET E 59 CE2 TRP D 159 1.71 REMARK 500 SD MET E 59 NE1 TRP D 159 1.73 REMARK 500 SD MET E 59 CZ2 TRP D 159 1.98 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLN E 87 74.86 53.92 REMARK 500 CYS F 96 98.01 -69.77 REMARK 500 MET C 66 38.22 -95.52 REMARK 500 LEU C 104 59.31 -90.41 REMARK 500 LEU C 160 33.36 -140.49 REMARK 500 LEU C 200 59.02 -93.13 REMARK 500 ASP C 265 135.62 -173.39 REMARK 500 LEU C 279 24.86 -141.22 REMARK 500 PRO C 283 49.05 -78.19 REMARK 500 LEU C 315 51.48 -92.76 REMARK 500 TYR C 352 -145.59 55.14 REMARK 500 ASN C 353 -174.74 63.50 REMARK 500 ILE C 389 -60.05 -107.61 REMARK 500 ARG C 392 -37.00 -130.08 REMARK 500 ARG C 398 16.55 57.78 REMARK 500 GLU C 424 66.67 -100.75 REMARK 500 ARG C 460 29.12 -140.45 REMARK 500 TYR C 466 -148.99 59.04 REMARK 500 ALA C 528 -6.38 76.51 REMARK 500 ARG C 604 21.67 -142.06 REMARK 500 MET D 66 38.17 -95.51 REMARK 500 LEU D 104 59.27 -90.42 REMARK 500 LEU D 160 33.37 -140.50 REMARK 500 LEU D 200 59.02 -93.14 REMARK 500 ASP D 265 135.61 -173.41 REMARK 500 LEU D 279 24.93 -141.23 REMARK 500 PRO D 283 49.08 -78.22 REMARK 500 LEU D 315 51.42 -92.79 REMARK 500 TYR D 352 -145.58 55.12 REMARK 500 ASN D 353 -174.72 63.53 REMARK 500 ARG D 392 -37.03 -130.06 REMARK 500 ARG D 398 16.57 57.73 REMARK 500 GLU D 424 66.66 -100.80 REMARK 500 ARG D 460 29.13 -140.50 REMARK 500 TYR D 466 -149.02 59.02 REMARK 500 ALA D 528 -6.39 76.51 REMARK 500 ARG D 604 21.65 -142.05 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-62340 RELATED DB: EMDB REMARK 900 STRUCTURE OF THE COMPLEX OF LGR4 WITH NORRIN (2:2) DBREF 9KHH A -18 537 PDB 9KHH 9KHH -18 537 DBREF 9KHH E 25 133 UNP Q00604 NDP_HUMAN 25 133 DBREF 9KHH E 158 387 UNP P0DOX5 IGG1_HUMAN 220 449 DBREF 9KHH F 25 133 UNP Q00604 NDP_HUMAN 25 133 DBREF 9KHH F 158 387 UNP P0DOX5 IGG1_HUMAN 220 449 DBREF 9KHH B -18 537 PDB 9KHH 9KHH -18 537 DBREF 9KHH C 24 951 UNP Q9BXB1 LGR4_HUMAN 24 951 DBREF 9KHH D 24 951 UNP Q9BXB1 LGR4_HUMAN 24 951 SEQADV 9KHH MET E -13 UNP Q00604 INITIATING METHIONINE SEQADV 9KHH LEU E -12 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU E -11 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL E -10 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ASN E -9 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLN E -8 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER E -7 UNP Q00604 EXPRESSION TAG SEQADV 9KHH HIS E -6 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLN E -5 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLY E -4 UNP Q00604 EXPRESSION TAG SEQADV 9KHH PHE E -3 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ASN E -2 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LYS E -1 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLU E 0 UNP Q00604 EXPRESSION TAG SEQADV 9KHH HIS E 1 UNP Q00604 EXPRESSION TAG SEQADV 9KHH THR E 2 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER E 3 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LYS E 4 UNP Q00604 EXPRESSION TAG SEQADV 9KHH MET E 5 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL E 6 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER E 7 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA E 8 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ILE E 9 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL E 10 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU E 11 UNP Q00604 EXPRESSION TAG SEQADV 9KHH TYR E 12 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL E 13 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU E 14 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU E 15 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA E 16 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA E 17 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA E 18 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA E 19 UNP Q00604 EXPRESSION TAG SEQADV 9KHH HIS E 20 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER E 21 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA E 22 UNP Q00604 EXPRESSION TAG SEQADV 9KHH PHE E 23 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA E 24 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLY E 134 UNP Q00604 LINKER SEQADV 9KHH GLY E 135 UNP Q00604 LINKER SEQADV 9KHH SER E 136 UNP Q00604 LINKER SEQADV 9KHH GLY E 137 UNP Q00604 LINKER SEQADV 9KHH GLY E 138 UNP Q00604 LINKER SEQADV 9KHH SER E 139 UNP Q00604 LINKER SEQADV 9KHH GLY E 140 UNP Q00604 LINKER SEQADV 9KHH GLY E 141 UNP Q00604 LINKER SEQADV 9KHH LEU E 142 UNP Q00604 LINKER SEQADV 9KHH GLU E 143 UNP Q00604 LINKER SEQADV 9KHH VAL E 144 UNP Q00604 LINKER SEQADV 9KHH LEU E 145 UNP Q00604 LINKER SEQADV 9KHH PHE E 146 UNP Q00604 LINKER SEQADV 9KHH GLN E 147 UNP Q00604 LINKER SEQADV 9KHH GLY E 148 UNP Q00604 LINKER SEQADV 9KHH PRO E 149 UNP Q00604 LINKER SEQADV 9KHH GLY E 150 UNP Q00604 LINKER SEQADV 9KHH GLY E 151 UNP Q00604 LINKER SEQADV 9KHH SER E 152 UNP Q00604 LINKER SEQADV 9KHH GLY E 153 UNP Q00604 LINKER SEQADV 9KHH GLY E 154 UNP Q00604 LINKER SEQADV 9KHH SER E 155 UNP Q00604 LINKER SEQADV 9KHH GLY E 156 UNP Q00604 LINKER SEQADV 9KHH GLY E 157 UNP Q00604 LINKER SEQADV 9KHH ALA E 333 UNP P0DOX5 THR 395 CONFLICT SEQADV 9KHH ASP E 388 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH TYR E 389 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH LYS E 390 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP E 391 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP E 392 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP E 393 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP E 394 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH LYS E 395 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH MET F -13 UNP Q00604 INITIATING METHIONINE SEQADV 9KHH LEU F -12 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU F -11 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL F -10 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ASN F -9 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLN F -8 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER F -7 UNP Q00604 EXPRESSION TAG SEQADV 9KHH HIS F -6 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLN F -5 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLY F -4 UNP Q00604 EXPRESSION TAG SEQADV 9KHH PHE F -3 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ASN F -2 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LYS F -1 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLU F 0 UNP Q00604 EXPRESSION TAG SEQADV 9KHH HIS F 1 UNP Q00604 EXPRESSION TAG SEQADV 9KHH THR F 2 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER F 3 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LYS F 4 UNP Q00604 EXPRESSION TAG SEQADV 9KHH MET F 5 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL F 6 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER F 7 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA F 8 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ILE F 9 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL F 10 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU F 11 UNP Q00604 EXPRESSION TAG SEQADV 9KHH TYR F 12 UNP Q00604 EXPRESSION TAG SEQADV 9KHH VAL F 13 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU F 14 UNP Q00604 EXPRESSION TAG SEQADV 9KHH LEU F 15 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA F 16 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA F 17 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA F 18 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA F 19 UNP Q00604 EXPRESSION TAG SEQADV 9KHH HIS F 20 UNP Q00604 EXPRESSION TAG SEQADV 9KHH SER F 21 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA F 22 UNP Q00604 EXPRESSION TAG SEQADV 9KHH PHE F 23 UNP Q00604 EXPRESSION TAG SEQADV 9KHH ALA F 24 UNP Q00604 EXPRESSION TAG SEQADV 9KHH GLY F 134 UNP Q00604 LINKER SEQADV 9KHH GLY F 135 UNP Q00604 LINKER SEQADV 9KHH SER F 136 UNP Q00604 LINKER SEQADV 9KHH GLY F 137 UNP Q00604 LINKER SEQADV 9KHH GLY F 138 UNP Q00604 LINKER SEQADV 9KHH SER F 139 UNP Q00604 LINKER SEQADV 9KHH GLY F 140 UNP Q00604 LINKER SEQADV 9KHH GLY F 141 UNP Q00604 LINKER SEQADV 9KHH LEU F 142 UNP Q00604 LINKER SEQADV 9KHH GLU F 143 UNP Q00604 LINKER SEQADV 9KHH VAL F 144 UNP Q00604 LINKER SEQADV 9KHH LEU F 145 UNP Q00604 LINKER SEQADV 9KHH PHE F 146 UNP Q00604 LINKER SEQADV 9KHH GLN F 147 UNP Q00604 LINKER SEQADV 9KHH GLY F 148 UNP Q00604 LINKER SEQADV 9KHH PRO F 149 UNP Q00604 LINKER SEQADV 9KHH GLY F 150 UNP Q00604 LINKER SEQADV 9KHH GLY F 151 UNP Q00604 LINKER SEQADV 9KHH SER F 152 UNP Q00604 LINKER SEQADV 9KHH GLY F 153 UNP Q00604 LINKER SEQADV 9KHH GLY F 154 UNP Q00604 LINKER SEQADV 9KHH SER F 155 UNP Q00604 LINKER SEQADV 9KHH GLY F 156 UNP Q00604 LINKER SEQADV 9KHH GLY F 157 UNP Q00604 LINKER SEQADV 9KHH ALA F 333 UNP P0DOX5 THR 395 CONFLICT SEQADV 9KHH ASP F 388 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH TYR F 389 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH LYS F 390 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP F 391 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP F 392 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP F 393 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH ASP F 394 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH LYS F 395 UNP P0DOX5 EXPRESSION TAG SEQADV 9KHH MET C 9 UNP Q9BXB1 INITIATING METHIONINE SEQADV 9KHH LYS C 10 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH THR C 11 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ILE C 12 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ILE C 13 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA C 14 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LEU C 15 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH SER C 16 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH TYR C 17 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ILE C 18 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH PHE C 19 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH CYS C 20 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LEU C 21 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH VAL C 22 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH PHE C 23 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA C 952 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA C 953 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA C 954 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP C 955 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH TYR C 956 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LYS C 957 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP C 958 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP C 959 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP C 960 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP C 961 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LYS C 962 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH MET D 9 UNP Q9BXB1 INITIATING METHIONINE SEQADV 9KHH LYS D 10 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH THR D 11 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ILE D 12 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ILE D 13 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA D 14 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LEU D 15 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH SER D 16 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH TYR D 17 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ILE D 18 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH PHE D 19 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH CYS D 20 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LEU D 21 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH VAL D 22 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH PHE D 23 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA D 952 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA D 953 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ALA D 954 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP D 955 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH TYR D 956 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LYS D 957 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP D 958 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP D 959 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP D 960 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH ASP D 961 UNP Q9BXB1 EXPRESSION TAG SEQADV 9KHH LYS D 962 UNP Q9BXB1 EXPRESSION TAG SEQRES 1 A 556 MET LYS LYS ILE TRP LEU ALA LEU ALA GLY LEU VAL LEU SEQRES 2 A 556 ALA PHE SER ALA SER ALA GLN VAL GLN LEU VAL GLU SER SEQRES 3 A 556 GLY GLY GLY LEU VAL GLN THR LYS THR THR THR SER VAL SEQRES 4 A 556 ILE ASP THR THR ASN ASP ALA GLN ASN LEU LEU THR GLN SEQRES 5 A 556 ALA GLN THR ILE VAL ASN THR LEU LYS ASP TYR CYS PRO SEQRES 6 A 556 ILE LEU ILE ALA LYS SER SER SER SER ASN GLY GLY THR SEQRES 7 A 556 ASN ASN ALA ASN THR PRO SER TRP GLN THR ALA GLY GLY SEQRES 8 A 556 GLY LYS ASN SER CYS ALA THR PHE GLY ALA GLU PHE SER SEQRES 9 A 556 ALA ALA SER ASP MET ILE ASN ASN ALA GLN LYS ILE VAL SEQRES 10 A 556 GLN GLU THR GLN GLN LEU SER ALA ASN GLN PRO LYS ASN SEQRES 11 A 556 ILE THR GLN PRO HIS ASN LEU ASN LEU ASN SER PRO SER SEQRES 12 A 556 SER LEU THR ALA LEU ALA GLN LYS MET LEU LYS ASN ALA SEQRES 13 A 556 GLN SER GLN ALA GLU ILE LEU LYS LEU ALA ASN GLN VAL SEQRES 14 A 556 GLU SER ASP PHE ASN LYS LEU SER SER GLY HIS LEU LYS SEQRES 15 A 556 ASP TYR ILE GLY LYS CYS ASP ALA SER ALA ILE SER SER SEQRES 16 A 556 ALA ASN MET THR MET GLN ASN GLN LYS ASN ASN TRP GLY SEQRES 17 A 556 ASN GLY CYS ALA GLY VAL GLU GLU THR GLN SER LEU LEU SEQRES 18 A 556 LYS THR SER ALA ALA ASP PHE ASN ASN GLN THR PRO GLN SEQRES 19 A 556 ILE ASN GLN ALA GLN ASN LEU ALA ASN THR LEU ILE GLN SEQRES 20 A 556 GLU LEU GLY ASN ASN PRO PHE ARG ALA SER GLY GLY GLY SEQRES 21 A 556 SER GLY GLY GLY GLY SER GLY LYS LEU SER ASP THR TYR SEQRES 22 A 556 GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY THR SEQRES 23 A 556 ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA VAL SEQRES 24 A 556 ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY GLY SEQRES 25 A 556 THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU ALA SEQRES 26 A 556 LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY TYR SEQRES 27 A 556 ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY GLU SEQRES 28 A 556 ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN GLY SEQRES 29 A 556 ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SER SEQRES 30 A 556 ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU LYS SEQRES 31 A 556 ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR GLU SEQRES 32 A 556 LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA LEU SEQRES 33 A 556 LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY GLU SEQRES 34 A 556 LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SER SEQRES 35 A 556 LEU ARG LEU SER CYS ALA ALA SER GLY TYR THR TYR SER SEQRES 36 A 556 PRO TYR CYS MET GLY TRP PHE ARG GLN ALA PRO GLY LYS SEQRES 37 A 556 ALA ARG GLU GLY VAL ALA THR VAL ASP LEU ASP GLY SER SEQRES 38 A 556 THR ILE TYR ALA ASP SER VAL LYS GLY ARG PHE THR ILE SEQRES 39 A 556 SER GLN ASP ASN ALA LYS ASN THR LEU TYR LEU GLN MET SEQRES 40 A 556 ASN SER LEU LYS PRO GLU ASP THR ALA MET TYR TYR CYS SEQRES 41 A 556 ALA SER ARG THR ARG ALA GLY VAL THR CYS GLY LEU ASN SEQRES 42 A 556 TRP ALA ILE PHE SER TYR TRP GLY GLN GLY THR GLN VAL SEQRES 43 A 556 THR VAL SER SER HIS HIS HIS HIS HIS HIS SEQRES 1 E 409 MET LEU LEU VAL ASN GLN SER HIS GLN GLY PHE ASN LYS SEQRES 2 E 409 GLU HIS THR SER LYS MET VAL SER ALA ILE VAL LEU TYR SEQRES 3 E 409 VAL LEU LEU ALA ALA ALA ALA HIS SER ALA PHE ALA LYS SEQRES 4 E 409 THR ASP SER SER PHE ILE MET ASP SER ASP PRO ARG ARG SEQRES 5 E 409 CYS MET ARG HIS HIS TYR VAL ASP SER ILE SER HIS PRO SEQRES 6 E 409 LEU TYR LYS CYS SER SER LYS MET VAL LEU LEU ALA ARG SEQRES 7 E 409 CYS GLU GLY HIS CYS SER GLN ALA SER ARG SER GLU PRO SEQRES 8 E 409 LEU VAL SER PHE SER THR VAL LEU LYS GLN PRO PHE ARG SEQRES 9 E 409 SER SER CYS HIS CYS CYS ARG PRO GLN THR SER LYS LEU SEQRES 10 E 409 LYS ALA LEU ARG LEU ARG CYS SER GLY GLY MET ARG LEU SEQRES 11 E 409 THR ALA THR TYR ARG TYR ILE LEU SER CYS HIS CYS GLU SEQRES 12 E 409 GLU CYS ASN SER GLY GLY SER GLY GLY SER GLY GLY LEU SEQRES 13 E 409 GLU VAL LEU PHE GLN GLY PRO GLY GLY SER GLY GLY SER SEQRES 14 E 409 GLY GLY LYS SER CYS ASP LYS THR HIS THR CYS PRO PRO SEQRES 15 E 409 CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL PHE SEQRES 16 E 409 LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SER SEQRES 17 E 409 ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SER SEQRES 18 E 409 HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL ASP SEQRES 19 E 409 GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG GLU SEQRES 20 E 409 GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL LEU SEQRES 21 E 409 THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU TYR SEQRES 22 E 409 LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO ILE SEQRES 23 E 409 GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG GLU SEQRES 24 E 409 PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU LEU SEQRES 25 E 409 THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS GLY SEQRES 26 E 409 PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER ASN SEQRES 27 E 409 GLY GLN PRO GLU ASN ASN TYR LYS ALA THR PRO PRO VAL SEQRES 28 E 409 LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS LEU SEQRES 29 E 409 THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL PHE SEQRES 30 E 409 SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS TYR SEQRES 31 E 409 THR GLN LYS SER LEU SER LEU SER PRO GLY LYS ASP TYR SEQRES 32 E 409 LYS ASP ASP ASP ASP LYS SEQRES 1 F 409 MET LEU LEU VAL ASN GLN SER HIS GLN GLY PHE ASN LYS SEQRES 2 F 409 GLU HIS THR SER LYS MET VAL SER ALA ILE VAL LEU TYR SEQRES 3 F 409 VAL LEU LEU ALA ALA ALA ALA HIS SER ALA PHE ALA LYS SEQRES 4 F 409 THR ASP SER SER PHE ILE MET ASP SER ASP PRO ARG ARG SEQRES 5 F 409 CYS MET ARG HIS HIS TYR VAL ASP SER ILE SER HIS PRO SEQRES 6 F 409 LEU TYR LYS CYS SER SER LYS MET VAL LEU LEU ALA ARG SEQRES 7 F 409 CYS GLU GLY HIS CYS SER GLN ALA SER ARG SER GLU PRO SEQRES 8 F 409 LEU VAL SER PHE SER THR VAL LEU LYS GLN PRO PHE ARG SEQRES 9 F 409 SER SER CYS HIS CYS CYS ARG PRO GLN THR SER LYS LEU SEQRES 10 F 409 LYS ALA LEU ARG LEU ARG CYS SER GLY GLY MET ARG LEU SEQRES 11 F 409 THR ALA THR TYR ARG TYR ILE LEU SER CYS HIS CYS GLU SEQRES 12 F 409 GLU CYS ASN SER GLY GLY SER GLY GLY SER GLY GLY LEU SEQRES 13 F 409 GLU VAL LEU PHE GLN GLY PRO GLY GLY SER GLY GLY SER SEQRES 14 F 409 GLY GLY LYS SER CYS ASP LYS THR HIS THR CYS PRO PRO SEQRES 15 F 409 CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL PHE SEQRES 16 F 409 LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SER SEQRES 17 F 409 ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SER SEQRES 18 F 409 HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL ASP SEQRES 19 F 409 GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG GLU SEQRES 20 F 409 GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL LEU SEQRES 21 F 409 THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU TYR SEQRES 22 F 409 LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO ILE SEQRES 23 F 409 GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG GLU SEQRES 24 F 409 PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU LEU SEQRES 25 F 409 THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS GLY SEQRES 26 F 409 PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER ASN SEQRES 27 F 409 GLY GLN PRO GLU ASN ASN TYR LYS ALA THR PRO PRO VAL SEQRES 28 F 409 LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS LEU SEQRES 29 F 409 THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL PHE SEQRES 30 F 409 SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS TYR SEQRES 31 F 409 THR GLN LYS SER LEU SER LEU SER PRO GLY LYS ASP TYR SEQRES 32 F 409 LYS ASP ASP ASP ASP LYS SEQRES 1 B 556 MET LYS LYS ILE TRP LEU ALA LEU ALA GLY LEU VAL LEU SEQRES 2 B 556 ALA PHE SER ALA SER ALA GLN VAL GLN LEU VAL GLU SER SEQRES 3 B 556 GLY GLY GLY LEU VAL GLN THR LYS THR THR THR SER VAL SEQRES 4 B 556 ILE ASP THR THR ASN ASP ALA GLN ASN LEU LEU THR GLN SEQRES 5 B 556 ALA GLN THR ILE VAL ASN THR LEU LYS ASP TYR CYS PRO SEQRES 6 B 556 ILE LEU ILE ALA LYS SER SER SER SER ASN GLY GLY THR SEQRES 7 B 556 ASN ASN ALA ASN THR PRO SER TRP GLN THR ALA GLY GLY SEQRES 8 B 556 GLY LYS ASN SER CYS ALA THR PHE GLY ALA GLU PHE SER SEQRES 9 B 556 ALA ALA SER ASP MET ILE ASN ASN ALA GLN LYS ILE VAL SEQRES 10 B 556 GLN GLU THR GLN GLN LEU SER ALA ASN GLN PRO LYS ASN SEQRES 11 B 556 ILE THR GLN PRO HIS ASN LEU ASN LEU ASN SER PRO SER SEQRES 12 B 556 SER LEU THR ALA LEU ALA GLN LYS MET LEU LYS ASN ALA SEQRES 13 B 556 GLN SER GLN ALA GLU ILE LEU LYS LEU ALA ASN GLN VAL SEQRES 14 B 556 GLU SER ASP PHE ASN LYS LEU SER SER GLY HIS LEU LYS SEQRES 15 B 556 ASP TYR ILE GLY LYS CYS ASP ALA SER ALA ILE SER SER SEQRES 16 B 556 ALA ASN MET THR MET GLN ASN GLN LYS ASN ASN TRP GLY SEQRES 17 B 556 ASN GLY CYS ALA GLY VAL GLU GLU THR GLN SER LEU LEU SEQRES 18 B 556 LYS THR SER ALA ALA ASP PHE ASN ASN GLN THR PRO GLN SEQRES 19 B 556 ILE ASN GLN ALA GLN ASN LEU ALA ASN THR LEU ILE GLN SEQRES 20 B 556 GLU LEU GLY ASN ASN PRO PHE ARG ALA SER GLY GLY GLY SEQRES 21 B 556 SER GLY GLY GLY GLY SER GLY LYS LEU SER ASP THR TYR SEQRES 22 B 556 GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY THR SEQRES 23 B 556 ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA VAL SEQRES 24 B 556 ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY GLY SEQRES 25 B 556 THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU ALA SEQRES 26 B 556 LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY TYR SEQRES 27 B 556 ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY GLU SEQRES 28 B 556 ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN GLY SEQRES 29 B 556 ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SER SEQRES 30 B 556 ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU LYS SEQRES 31 B 556 ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR GLU SEQRES 32 B 556 LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA LEU SEQRES 33 B 556 LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY GLU SEQRES 34 B 556 LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SER SEQRES 35 B 556 LEU ARG LEU SER CYS ALA ALA SER GLY TYR THR TYR SER SEQRES 36 B 556 PRO TYR CYS MET GLY TRP PHE ARG GLN ALA PRO GLY LYS SEQRES 37 B 556 ALA ARG GLU GLY VAL ALA THR VAL ASP LEU ASP GLY SER SEQRES 38 B 556 THR ILE TYR ALA ASP SER VAL LYS GLY ARG PHE THR ILE SEQRES 39 B 556 SER GLN ASP ASN ALA LYS ASN THR LEU TYR LEU GLN MET SEQRES 40 B 556 ASN SER LEU LYS PRO GLU ASP THR ALA MET TYR TYR CYS SEQRES 41 B 556 ALA SER ARG THR ARG ALA GLY VAL THR CYS GLY LEU ASN SEQRES 42 B 556 TRP ALA ILE PHE SER TYR TRP GLY GLN GLY THR GLN VAL SEQRES 43 B 556 THR VAL SER SER HIS HIS HIS HIS HIS HIS SEQRES 1 C 954 MET LYS THR ILE ILE ALA LEU SER TYR ILE PHE CYS LEU SEQRES 2 C 954 VAL PHE ALA ALA PRO PRO LEU CYS ALA ALA PRO CYS SER SEQRES 3 C 954 CYS ASP GLY ASP ARG ARG VAL ASP CYS SER GLY LYS GLY SEQRES 4 C 954 LEU THR ALA VAL PRO GLU GLY LEU SER ALA PHE THR GLN SEQRES 5 C 954 ALA LEU ASP ILE SER MET ASN ASN ILE THR GLN LEU PRO SEQRES 6 C 954 GLU ASP ALA PHE LYS ASN PHE PRO PHE LEU GLU GLU LEU SEQRES 7 C 954 GLN LEU ALA GLY ASN ASP LEU SER PHE ILE HIS PRO LYS SEQRES 8 C 954 ALA LEU SER GLY LEU LYS GLU LEU LYS VAL LEU THR LEU SEQRES 9 C 954 GLN ASN ASN GLN LEU LYS THR VAL PRO SER GLU ALA ILE SEQRES 10 C 954 ARG GLY LEU SER ALA LEU GLN SER LEU ARG LEU ASP ALA SEQRES 11 C 954 ASN HIS ILE THR SER VAL PRO GLU ASP SER PHE GLU GLY SEQRES 12 C 954 LEU VAL GLN LEU ARG HIS LEU TRP LEU ASP ASP ASN SER SEQRES 13 C 954 LEU THR GLU VAL PRO VAL HIS PRO LEU SER ASN LEU PRO SEQRES 14 C 954 THR LEU GLN ALA LEU THR LEU ALA LEU ASN LYS ILE SER SEQRES 15 C 954 SER ILE PRO ASP PHE ALA PHE THR ASN LEU SER SER LEU SEQRES 16 C 954 VAL VAL LEU HIS LEU HIS ASN ASN LYS ILE ARG SER LEU SEQRES 17 C 954 SER GLN HIS CYS PHE ASP GLY LEU ASP ASN LEU GLU THR SEQRES 18 C 954 LEU ASP LEU ASN TYR ASN ASN LEU GLY GLU PHE PRO GLN SEQRES 19 C 954 ALA ILE LYS ALA LEU PRO SER LEU LYS GLU LEU GLY PHE SEQRES 20 C 954 HIS SER ASN SER ILE SER VAL ILE PRO ASP GLY ALA PHE SEQRES 21 C 954 ASP GLY ASN PRO LEU LEU ARG THR ILE HIS LEU TYR ASP SEQRES 22 C 954 ASN PRO LEU SER PHE VAL GLY ASN SER ALA PHE HIS ASN SEQRES 23 C 954 LEU SER ASP LEU HIS SER LEU VAL ILE ARG GLY ALA SER SEQRES 24 C 954 MET VAL GLN GLN PHE PRO ASN LEU THR GLY THR VAL HIS SEQRES 25 C 954 LEU GLU SER LEU THR LEU THR GLY THR LYS ILE SER SER SEQRES 26 C 954 ILE PRO ASN ASN LEU CYS GLN GLU GLN LYS MET LEU ARG SEQRES 27 C 954 THR LEU ASP LEU SER TYR ASN ASN ILE ARG ASP LEU PRO SEQRES 28 C 954 SER PHE ASN GLY CYS HIS ALA LEU GLU GLU ILE SER LEU SEQRES 29 C 954 GLN ARG ASN GLN ILE TYR GLN ILE LYS GLU GLY THR PHE SEQRES 30 C 954 GLN GLY LEU ILE SER LEU ARG ILE LEU ASP LEU SER ARG SEQRES 31 C 954 ASN LEU ILE HIS GLU ILE HIS SER ARG ALA PHE ALA THR SEQRES 32 C 954 LEU GLY PRO ILE THR ASN LEU ASP VAL SER PHE ASN GLU SEQRES 33 C 954 LEU THR SER PHE PRO THR GLU GLY LEU ASN GLY LEU ASN SEQRES 34 C 954 GLN LEU LYS LEU VAL GLY ASN PHE LYS LEU LYS GLU ALA SEQRES 35 C 954 LEU ALA ALA LYS ASP PHE VAL ASN LEU ARG SER LEU SER SEQRES 36 C 954 VAL PRO TYR ALA TYR GLN CYS CYS ALA PHE TRP GLY CYS SEQRES 37 C 954 ASP SER TYR ALA ASN LEU ASN THR GLU ASP ASN SER LEU SEQRES 38 C 954 GLN ASP HIS SER VAL ALA GLN GLU LYS GLY THR ALA ASP SEQRES 39 C 954 ALA ALA ASN VAL THR SER THR LEU GLU ASN GLU GLU HIS SEQRES 40 C 954 SER GLN ILE ILE ILE HIS CYS THR PRO SER THR GLY ALA SEQRES 41 C 954 PHE LYS PRO CYS GLU TYR LEU LEU GLY SER TRP MET ILE SEQRES 42 C 954 ARG LEU THR VAL TRP PHE ILE PHE LEU VAL ALA LEU PHE SEQRES 43 C 954 PHE ASN LEU LEU VAL ILE LEU THR THR PHE ALA SER CYS SEQRES 44 C 954 THR SER LEU PRO SER SER LYS LEU PHE ILE GLY LEU ILE SEQRES 45 C 954 SER VAL SER ASN LEU PHE MET GLY ILE TYR THR GLY ILE SEQRES 46 C 954 LEU THR PHE LEU ASP ALA VAL SER TRP GLY ARG PHE ALA SEQRES 47 C 954 GLU PHE GLY ILE TRP TRP GLU THR GLY SER GLY CYS LYS SEQRES 48 C 954 VAL ALA GLY PHE LEU ALA VAL PHE SER SER GLU SER ALA SEQRES 49 C 954 ILE PHE LEU LEU MET LEU ALA THR VAL GLU ARG SER LEU SEQRES 50 C 954 SER ALA LYS ASP ILE MET LYS ASN GLY LYS SER ASN HIS SEQRES 51 C 954 LEU LYS GLN PHE ARG VAL ALA ALA LEU LEU ALA PHE LEU SEQRES 52 C 954 GLY ALA THR VAL ALA GLY CYS PHE PRO LEU PHE HIS ARG SEQRES 53 C 954 GLY GLU TYR SER ALA SER PRO LEU CYS LEU PRO PHE PRO SEQRES 54 C 954 THR GLY GLU THR PRO SER LEU GLY PHE THR VAL THR LEU SEQRES 55 C 954 VAL LEU LEU ASN SER LEU ALA PHE LEU LEU MET ALA VAL SEQRES 56 C 954 ILE TYR THR LYS LEU TYR CYS ASN LEU GLU LYS GLU ASP SEQRES 57 C 954 LEU SER GLU ASN SER GLN SER SER MET ILE LYS HIS VAL SEQRES 58 C 954 ALA TRP LEU ILE PHE THR ASN CYS ILE PHE PHE CYS PRO SEQRES 59 C 954 VAL ALA PHE PHE SER PHE ALA PRO LEU ILE THR ALA ILE SEQRES 60 C 954 SER ILE SER PRO GLU ILE MET LYS SER VAL THR LEU ILE SEQRES 61 C 954 PHE PHE PRO LEU PRO ALA CYS LEU ASN PRO VAL LEU TYR SEQRES 62 C 954 VAL PHE PHE ASN PRO LYS PHE LYS GLU ASP TRP LYS LEU SEQRES 63 C 954 LEU LYS ARG ARG VAL THR LYS LYS SER GLY SER VAL SER SEQRES 64 C 954 VAL SER ILE SER SER GLN GLY GLY CYS LEU GLU GLN ASP SEQRES 65 C 954 PHE TYR TYR ASP CYS GLY MET TYR SER HIS LEU GLN GLY SEQRES 66 C 954 ASN LEU THR VAL CYS ASP CYS CYS GLU SER PHE LEU LEU SEQRES 67 C 954 THR LYS PRO VAL SER CYS LYS HIS LEU ILE LYS SER HIS SEQRES 68 C 954 SER CYS PRO ALA LEU ALA VAL ALA SER CYS GLN ARG PRO SEQRES 69 C 954 GLU GLY TYR TRP SER ASP CYS GLY THR GLN SER ALA HIS SEQRES 70 C 954 SER ASP TYR ALA ASP GLU GLU ASP SER PHE VAL SER ASP SEQRES 71 C 954 SER SER ASP GLN VAL GLN ALA CYS GLY ARG ALA CYS PHE SEQRES 72 C 954 TYR GLN SER ARG GLY PHE PRO LEU VAL ARG TYR ALA TYR SEQRES 73 C 954 ASN LEU PRO ARG VAL LYS ASP ALA ALA ALA ASP TYR LYS SEQRES 74 C 954 ASP ASP ASP ASP LYS SEQRES 1 D 954 MET LYS THR ILE ILE ALA LEU SER TYR ILE PHE CYS LEU SEQRES 2 D 954 VAL PHE ALA ALA PRO PRO LEU CYS ALA ALA PRO CYS SER SEQRES 3 D 954 CYS ASP GLY ASP ARG ARG VAL ASP CYS SER GLY LYS GLY SEQRES 4 D 954 LEU THR ALA VAL PRO GLU GLY LEU SER ALA PHE THR GLN SEQRES 5 D 954 ALA LEU ASP ILE SER MET ASN ASN ILE THR GLN LEU PRO SEQRES 6 D 954 GLU ASP ALA PHE LYS ASN PHE PRO PHE LEU GLU GLU LEU SEQRES 7 D 954 GLN LEU ALA GLY ASN ASP LEU SER PHE ILE HIS PRO LYS SEQRES 8 D 954 ALA LEU SER GLY LEU LYS GLU LEU LYS VAL LEU THR LEU SEQRES 9 D 954 GLN ASN ASN GLN LEU LYS THR VAL PRO SER GLU ALA ILE SEQRES 10 D 954 ARG GLY LEU SER ALA LEU GLN SER LEU ARG LEU ASP ALA SEQRES 11 D 954 ASN HIS ILE THR SER VAL PRO GLU ASP SER PHE GLU GLY SEQRES 12 D 954 LEU VAL GLN LEU ARG HIS LEU TRP LEU ASP ASP ASN SER SEQRES 13 D 954 LEU THR GLU VAL PRO VAL HIS PRO LEU SER ASN LEU PRO SEQRES 14 D 954 THR LEU GLN ALA LEU THR LEU ALA LEU ASN LYS ILE SER SEQRES 15 D 954 SER ILE PRO ASP PHE ALA PHE THR ASN LEU SER SER LEU SEQRES 16 D 954 VAL VAL LEU HIS LEU HIS ASN ASN LYS ILE ARG SER LEU SEQRES 17 D 954 SER GLN HIS CYS PHE ASP GLY LEU ASP ASN LEU GLU THR SEQRES 18 D 954 LEU ASP LEU ASN TYR ASN ASN LEU GLY GLU PHE PRO GLN SEQRES 19 D 954 ALA ILE LYS ALA LEU PRO SER LEU LYS GLU LEU GLY PHE SEQRES 20 D 954 HIS SER ASN SER ILE SER VAL ILE PRO ASP GLY ALA PHE SEQRES 21 D 954 ASP GLY ASN PRO LEU LEU ARG THR ILE HIS LEU TYR ASP SEQRES 22 D 954 ASN PRO LEU SER PHE VAL GLY ASN SER ALA PHE HIS ASN SEQRES 23 D 954 LEU SER ASP LEU HIS SER LEU VAL ILE ARG GLY ALA SER SEQRES 24 D 954 MET VAL GLN GLN PHE PRO ASN LEU THR GLY THR VAL HIS SEQRES 25 D 954 LEU GLU SER LEU THR LEU THR GLY THR LYS ILE SER SER SEQRES 26 D 954 ILE PRO ASN ASN LEU CYS GLN GLU GLN LYS MET LEU ARG SEQRES 27 D 954 THR LEU ASP LEU SER TYR ASN ASN ILE ARG ASP LEU PRO SEQRES 28 D 954 SER PHE ASN GLY CYS HIS ALA LEU GLU GLU ILE SER LEU SEQRES 29 D 954 GLN ARG ASN GLN ILE TYR GLN ILE LYS GLU GLY THR PHE SEQRES 30 D 954 GLN GLY LEU ILE SER LEU ARG ILE LEU ASP LEU SER ARG SEQRES 31 D 954 ASN LEU ILE HIS GLU ILE HIS SER ARG ALA PHE ALA THR SEQRES 32 D 954 LEU GLY PRO ILE THR ASN LEU ASP VAL SER PHE ASN GLU SEQRES 33 D 954 LEU THR SER PHE PRO THR GLU GLY LEU ASN GLY LEU ASN SEQRES 34 D 954 GLN LEU LYS LEU VAL GLY ASN PHE LYS LEU LYS GLU ALA SEQRES 35 D 954 LEU ALA ALA LYS ASP PHE VAL ASN LEU ARG SER LEU SER SEQRES 36 D 954 VAL PRO TYR ALA TYR GLN CYS CYS ALA PHE TRP GLY CYS SEQRES 37 D 954 ASP SER TYR ALA ASN LEU ASN THR GLU ASP ASN SER LEU SEQRES 38 D 954 GLN ASP HIS SER VAL ALA GLN GLU LYS GLY THR ALA ASP SEQRES 39 D 954 ALA ALA ASN VAL THR SER THR LEU GLU ASN GLU GLU HIS SEQRES 40 D 954 SER GLN ILE ILE ILE HIS CYS THR PRO SER THR GLY ALA SEQRES 41 D 954 PHE LYS PRO CYS GLU TYR LEU LEU GLY SER TRP MET ILE SEQRES 42 D 954 ARG LEU THR VAL TRP PHE ILE PHE LEU VAL ALA LEU PHE SEQRES 43 D 954 PHE ASN LEU LEU VAL ILE LEU THR THR PHE ALA SER CYS SEQRES 44 D 954 THR SER LEU PRO SER SER LYS LEU PHE ILE GLY LEU ILE SEQRES 45 D 954 SER VAL SER ASN LEU PHE MET GLY ILE TYR THR GLY ILE SEQRES 46 D 954 LEU THR PHE LEU ASP ALA VAL SER TRP GLY ARG PHE ALA SEQRES 47 D 954 GLU PHE GLY ILE TRP TRP GLU THR GLY SER GLY CYS LYS SEQRES 48 D 954 VAL ALA GLY PHE LEU ALA VAL PHE SER SER GLU SER ALA SEQRES 49 D 954 ILE PHE LEU LEU MET LEU ALA THR VAL GLU ARG SER LEU SEQRES 50 D 954 SER ALA LYS ASP ILE MET LYS ASN GLY LYS SER ASN HIS SEQRES 51 D 954 LEU LYS GLN PHE ARG VAL ALA ALA LEU LEU ALA PHE LEU SEQRES 52 D 954 GLY ALA THR VAL ALA GLY CYS PHE PRO LEU PHE HIS ARG SEQRES 53 D 954 GLY GLU TYR SER ALA SER PRO LEU CYS LEU PRO PHE PRO SEQRES 54 D 954 THR GLY GLU THR PRO SER LEU GLY PHE THR VAL THR LEU SEQRES 55 D 954 VAL LEU LEU ASN SER LEU ALA PHE LEU LEU MET ALA VAL SEQRES 56 D 954 ILE TYR THR LYS LEU TYR CYS ASN LEU GLU LYS GLU ASP SEQRES 57 D 954 LEU SER GLU ASN SER GLN SER SER MET ILE LYS HIS VAL SEQRES 58 D 954 ALA TRP LEU ILE PHE THR ASN CYS ILE PHE PHE CYS PRO SEQRES 59 D 954 VAL ALA PHE PHE SER PHE ALA PRO LEU ILE THR ALA ILE SEQRES 60 D 954 SER ILE SER PRO GLU ILE MET LYS SER VAL THR LEU ILE SEQRES 61 D 954 PHE PHE PRO LEU PRO ALA CYS LEU ASN PRO VAL LEU TYR SEQRES 62 D 954 VAL PHE PHE ASN PRO LYS PHE LYS GLU ASP TRP LYS LEU SEQRES 63 D 954 LEU LYS ARG ARG VAL THR LYS LYS SER GLY SER VAL SER SEQRES 64 D 954 VAL SER ILE SER SER GLN GLY GLY CYS LEU GLU GLN ASP SEQRES 65 D 954 PHE TYR TYR ASP CYS GLY MET TYR SER HIS LEU GLN GLY SEQRES 66 D 954 ASN LEU THR VAL CYS ASP CYS CYS GLU SER PHE LEU LEU SEQRES 67 D 954 THR LYS PRO VAL SER CYS LYS HIS LEU ILE LYS SER HIS SEQRES 68 D 954 SER CYS PRO ALA LEU ALA VAL ALA SER CYS GLN ARG PRO SEQRES 69 D 954 GLU GLY TYR TRP SER ASP CYS GLY THR GLN SER ALA HIS SEQRES 70 D 954 SER ASP TYR ALA ASP GLU GLU ASP SER PHE VAL SER ASP SEQRES 71 D 954 SER SER ASP GLN VAL GLN ALA CYS GLY ARG ALA CYS PHE SEQRES 72 D 954 TYR GLN SER ARG GLY PHE PRO LEU VAL ARG TYR ALA TYR SEQRES 73 D 954 ASN LEU PRO ARG VAL LYS ASP ALA ALA ALA ASP TYR LYS SEQRES 74 D 954 ASP ASP ASP ASP LYS HELIX 1 AA1 ASP A 467 LYS A 470 5 4 HELIX 2 AA2 LYS A 492 THR A 496 5 5 HELIX 3 AA3 SER F 111 GLY F 113 5 3 HELIX 4 AA4 ASP B 467 LYS B 470 5 4 HELIX 5 AA5 LYS B 492 THR B 496 5 5 HELIX 6 AA6 PRO C 121 ARG C 126 1 6 HELIX 7 AA7 PRO C 169 ASN C 175 1 7 HELIX 8 AA8 PRO C 241 LEU C 247 5 7 HELIX 9 AA9 ASN C 337 GLN C 342 1 6 HELIX 10 AB1 HIS C 405 ALA C 410 5 6 HELIX 11 AB2 SER C 538 CYS C 567 1 30 HELIX 12 AB3 PRO C 571 SER C 601 1 31 HELIX 13 AB4 ARG C 604 GLY C 615 1 12 HELIX 14 AB5 GLY C 615 ASP C 649 1 35 HELIX 15 AB6 HIS C 658 HIS C 683 1 26 HELIX 16 AB7 GLU C 686 SER C 690 5 5 HELIX 17 AB8 SER C 703 CYS C 730 1 28 HELIX 18 AB9 MET C 745 PHE C 768 1 24 HELIX 19 AC1 SER C 778 PHE C 790 1 13 HELIX 20 AC2 PRO C 791 PHE C 803 1 13 HELIX 21 AC3 ASN C 805 THR C 820 1 16 HELIX 22 AC4 PRO D 121 ARG D 126 1 6 HELIX 23 AC5 PRO D 169 ASN D 175 1 7 HELIX 24 AC6 PRO D 241 LEU D 247 5 7 HELIX 25 AC7 ASN D 337 GLN D 342 1 6 HELIX 26 AC8 HIS D 405 ALA D 410 5 6 HELIX 27 AC9 SER D 538 CYS D 567 1 30 HELIX 28 AD1 PRO D 571 SER D 601 1 31 HELIX 29 AD2 ARG D 604 GLY D 615 1 12 HELIX 30 AD3 GLY D 615 ASP D 649 1 35 HELIX 31 AD4 HIS D 658 HIS D 683 1 26 HELIX 32 AD5 GLU D 686 SER D 690 5 5 HELIX 33 AD6 SER D 703 CYS D 730 1 28 HELIX 34 AD7 MET D 745 PHE D 768 1 24 HELIX 35 AD8 SER D 778 PHE D 790 1 13 HELIX 36 AD9 PRO D 791 PHE D 803 1 13 HELIX 37 AE1 ASN D 805 THR D 820 1 16 SHEET 1 AA1 3 LEU A 424 LEU A 426 0 SHEET 2 AA1 3 LEU A 486 MET A 488 -1 O LEU A 486 N LEU A 426 SHEET 3 AA1 3 PHE A 473 ILE A 475 -1 N THR A 474 O GLN A 487 SHEET 1 AA2 5 THR A 463 TYR A 465 0 SHEET 2 AA2 5 ARG A 451 ASP A 458 -1 N THR A 456 O ILE A 464 SHEET 3 AA2 5 CYS A 439 GLN A 445 -1 N MET A 440 O VAL A 457 SHEET 4 AA2 5 ALA A 497 ARG A 504 -1 O ALA A 502 N GLY A 441 SHEET 5 AA2 5 TYR A 520 TRP A 521 -1 O TYR A 520 N SER A 503 SHEET 1 AA3 5 THR A 463 TYR A 465 0 SHEET 2 AA3 5 ARG A 451 ASP A 458 -1 N THR A 456 O ILE A 464 SHEET 3 AA3 5 CYS A 439 GLN A 445 -1 N MET A 440 O VAL A 457 SHEET 4 AA3 5 ALA A 497 ARG A 504 -1 O ALA A 502 N GLY A 441 SHEET 5 AA3 5 THR A 525 VAL A 527 -1 O VAL A 527 N ALA A 497 SHEET 1 AA4 4 MET E 40 ASP E 46 0 SHEET 2 AA4 4 VAL E 60 GLY E 67 -1 O LEU E 62 N TYR E 44 SHEET 3 AA4 4 SER F 73 PRO F 77 -1 O SER F 75 N CYS E 65 SHEET 4 AA4 4 PHE F 89 SER F 92 -1 O ARG F 90 N GLU F 76 SHEET 1 AA5 4 PHE E 89 SER E 92 0 SHEET 2 AA5 4 SER E 73 PRO E 77 -1 N ARG E 74 O SER E 92 SHEET 3 AA5 4 LYS F 58 GLY F 67 -1 O GLY F 67 N SER E 73 SHEET 4 AA5 4 MET F 40 ILE F 48 -1 N TYR F 44 O LEU F 62 SHEET 1 AA6 2 HIS E 94 ARG E 97 0 SHEET 2 AA6 2 HIS E 127 GLU E 130 -1 O GLU E 129 N CYS E 95 SHEET 1 AA7 3 SER E 101 ARG E 109 0 SHEET 2 AA7 3 ARG E 115 ILE E 123 -1 O TYR E 120 N LYS E 104 SHEET 3 AA7 3 VAL F 79 SER F 80 -1 O SER F 80 N THR E 119 SHEET 1 AA8 2 HIS F 94 ARG F 109 0 SHEET 2 AA8 2 ARG F 115 GLU F 130 -1 O TYR F 120 N LYS F 104 SHEET 1 AA9 3 LEU B 424 LEU B 426 0 SHEET 2 AA9 3 LEU B 486 MET B 488 -1 O LEU B 486 N LEU B 426 SHEET 3 AA9 3 PHE B 473 ILE B 475 -1 N THR B 474 O GLN B 487 SHEET 1 AB1 5 THR B 463 TYR B 465 0 SHEET 2 AB1 5 ARG B 451 ASP B 458 -1 N THR B 456 O ILE B 464 SHEET 3 AB1 5 CYS B 439 GLN B 445 -1 N MET B 440 O VAL B 457 SHEET 4 AB1 5 ALA B 497 ARG B 504 -1 O ALA B 502 N GLY B 441 SHEET 5 AB1 5 TYR B 520 TRP B 521 -1 O TYR B 520 N SER B 503 SHEET 1 AB2 5 THR B 463 TYR B 465 0 SHEET 2 AB2 5 ARG B 451 ASP B 458 -1 N THR B 456 O ILE B 464 SHEET 3 AB2 5 CYS B 439 GLN B 445 -1 N MET B 440 O VAL B 457 SHEET 4 AB2 5 ALA B 497 ARG B 504 -1 O ALA B 502 N GLY B 441 SHEET 5 AB2 5 THR B 525 VAL B 527 -1 O VAL B 527 N ALA B 497 SHEET 1 AB311 ARG C 40 ASP C 42 0 SHEET 2 AB311 ALA C 61 ASP C 63 1 O ALA C 61 N VAL C 41 SHEET 3 AB311 GLU C 85 GLN C 87 1 O GLU C 85 N LEU C 62 SHEET 4 AB311 VAL C 109 THR C 111 1 O VAL C 109 N LEU C 86 SHEET 5 AB311 SER C 133 ARG C 135 1 O ARG C 135 N LEU C 110 SHEET 6 AB311 HIS C 157 TRP C 159 1 O TRP C 159 N LEU C 134 SHEET 7 AB311 ALA C 181 THR C 183 1 O ALA C 181 N LEU C 158 SHEET 8 AB311 VAL C 205 HIS C 207 1 O VAL C 205 N LEU C 182 SHEET 9 AB311 THR C 229 ASP C 231 1 O ASP C 231 N LEU C 206 SHEET 10 AB311 GLU C 252 GLY C 254 1 O GLU C 252 N LEU C 230 SHEET 11 AB311 THR C 276 HIS C 278 1 O THR C 276 N LEU C 253 SHEET 1 AB4 2 GLN C 71 LEU C 72 0 SHEET 2 AB4 2 PHE C 95 ILE C 96 1 O PHE C 95 N LEU C 72 SHEET 1 AB5 2 SER C 191 ILE C 192 0 SHEET 2 AB5 2 SER C 215 LEU C 216 1 O SER C 215 N ILE C 192 SHEET 1 AB6 2 VAL C 262 ILE C 263 0 SHEET 2 AB6 2 PHE C 286 VAL C 287 1 O PHE C 286 N ILE C 263 SHEET 1 AB7 9 SER C 300 ARG C 304 0 SHEET 2 AB7 9 SER C 323 THR C 327 1 O THR C 325 N ILE C 303 SHEET 3 AB7 9 THR C 347 ASP C 349 1 O ASP C 349 N LEU C 326 SHEET 4 AB7 9 GLU C 369 SER C 371 1 O SER C 371 N LEU C 348 SHEET 5 AB7 9 ILE C 393 ASP C 395 1 O ILE C 393 N ILE C 370 SHEET 6 AB7 9 ASN C 417 ASP C 419 1 O ASN C 417 N LEU C 394 SHEET 7 AB7 9 GLN C 438 LYS C 440 1 O LYS C 440 N LEU C 418 SHEET 8 AB7 9 SER C 461 SER C 463 1 O SER C 461 N LEU C 439 SHEET 9 AB7 9 HIS C 521 CYS C 522 1 O HIS C 521 N LEU C 462 SHEET 1 AB811 ARG D 40 ASP D 42 0 SHEET 2 AB811 ALA D 61 ASP D 63 1 O ALA D 61 N VAL D 41 SHEET 3 AB811 GLU D 85 GLN D 87 1 O GLU D 85 N LEU D 62 SHEET 4 AB811 VAL D 109 THR D 111 1 O VAL D 109 N LEU D 86 SHEET 5 AB811 SER D 133 ARG D 135 1 O ARG D 135 N LEU D 110 SHEET 6 AB811 HIS D 157 TRP D 159 1 O TRP D 159 N LEU D 134 SHEET 7 AB811 ALA D 181 THR D 183 1 O ALA D 181 N LEU D 158 SHEET 8 AB811 VAL D 205 HIS D 207 1 O VAL D 205 N LEU D 182 SHEET 9 AB811 THR D 229 ASP D 231 1 O ASP D 231 N LEU D 206 SHEET 10 AB811 GLU D 252 GLY D 254 1 O GLU D 252 N LEU D 230 SHEET 11 AB811 THR D 276 HIS D 278 1 O THR D 276 N LEU D 253 SHEET 1 AB9 2 GLN D 71 LEU D 72 0 SHEET 2 AB9 2 PHE D 95 ILE D 96 1 O PHE D 95 N LEU D 72 SHEET 1 AC1 2 SER D 191 ILE D 192 0 SHEET 2 AC1 2 SER D 215 LEU D 216 1 O SER D 215 N ILE D 192 SHEET 1 AC2 2 VAL D 262 ILE D 263 0 SHEET 2 AC2 2 PHE D 286 VAL D 287 1 O PHE D 286 N ILE D 263 SHEET 1 AC3 8 SER D 300 ARG D 304 0 SHEET 2 AC3 8 SER D 323 THR D 327 1 O THR D 325 N ILE D 303 SHEET 3 AC3 8 THR D 347 ASP D 349 1 O ASP D 349 N LEU D 326 SHEET 4 AC3 8 GLU D 369 SER D 371 1 O SER D 371 N LEU D 348 SHEET 5 AC3 8 ILE D 393 ASP D 395 1 O ILE D 393 N ILE D 370 SHEET 6 AC3 8 ASN D 417 ASP D 419 1 O ASN D 417 N LEU D 394 SHEET 7 AC3 8 GLN D 438 LYS D 440 1 O LYS D 440 N LEU D 418 SHEET 8 AC3 8 SER D 461 SER D 463 1 O SER D 461 N LEU D 439 SSBOND 1 CYS A 428 CYS A 501 1555 1555 2.04 SSBOND 2 CYS E 39 CYS E 96 1555 1555 2.03 SSBOND 3 CYS E 55 CYS E 110 1555 1555 2.03 SSBOND 4 CYS E 65 CYS E 126 1555 1555 2.03 SSBOND 5 CYS E 69 CYS E 128 1555 1555 2.03 SSBOND 6 CYS E 93 CYS F 95 1555 1555 2.04 SSBOND 7 CYS E 95 CYS F 93 1555 1555 2.03 SSBOND 8 CYS E 131 CYS F 131 1555 1555 2.03 SSBOND 9 CYS F 39 CYS F 96 1555 1555 2.03 SSBOND 10 CYS F 55 CYS F 110 1555 1555 2.03 SSBOND 11 CYS F 65 CYS F 126 1555 1555 2.03 SSBOND 12 CYS F 69 CYS F 128 1555 1555 2.03 SSBOND 13 CYS B 428 CYS B 501 1555 1555 2.04 SSBOND 14 CYS C 33 CYS C 43 1555 1555 2.03 SSBOND 15 CYS C 339 CYS C 364 1555 1555 2.03 SSBOND 16 CYS D 33 CYS D 43 1555 1555 2.04 SSBOND 17 CYS D 339 CYS D 364 1555 1555 2.03 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000