HEADER VIRAL PROTEIN/IMMUNE SYSTEM 10-DEC-24 9KZD TITLE THE LOCAL REFINED MAP OF SARS-COV-2 EG.5.1 VARIANT SPIKE PROTEIN TITLE 2 COMPLEXED WITH ANTIBODY XGI-171 COMPND MOL_ID: 1; COMPND 2 MOLECULE: XGI-171 HEAVY CHAIN; COMPND 3 CHAIN: H; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: XGI-171 LIGHT CHAIN; COMPND 7 CHAIN: L; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 11 CHAIN: A; COMPND 12 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 13 2; SOURCE 14 ORGANISM_TAXID: 2697049; SOURCE 15 STRAIN: OMICRON/EG.5.1; SOURCE 16 GENE: S, 2; SOURCE 17 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 18 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM_CELL_LINE: HEK293F KEYWDS SPIKE-ANTIBODY COMPLEX, VIRAL PROTEIN/IMMUNE SYSTEM, VIRAL PROTEIN- KEYWDS 2 IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR Y.N.QIU,L.SUN REVDAT 1 10-DEC-25 9KZD 0 JRNL AUTH M.XIE,Y.QIU,X.ZHAO,J.SHI,Y.LIU,Q.ZHANG,J.HE,J.LI,L.LIU, JRNL AUTH 2 S.SUN,Y.ZHU,Q.MAO,Y.LONG,T.Y.OLIVEIRA,Z.WANG,Y.ZHOU,Y.YAN, JRNL AUTH 3 A.XIA,W.ZAI,C.T.MAYER,Y.XIE,S.JIANG,L.LU,R.XIA,F.WU,L.SUN, JRNL AUTH 4 P.WANG,H.CHU,Q.WANG JRNL TITL ORPHAN BROADLY RBD-BINDING ANTIBODIES ANNOTATE THREE JRNL TITL 2 REMAINING CONSERVED RBD EPITOPES ALONG SARS-COV-2 EVOLUTION. JRNL REF NAT COMMUN V. 16 10566 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 41298374 JRNL DOI 10.1038/S41467-025-65596-0 REMARK 2 REMARK 2 RESOLUTION. 3.65 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.650 REMARK 3 NUMBER OF PARTICLES : 30115 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9KZD COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 13-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1300054497. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : EG.5.1 SPIKE PROTEIN (S) IN REMARK 245 COMPLEX WITH ANTIBODY XGI-171; REMARK 245 XGI-171 HEAVY CHAIN; XGI-171 REMARK 245 LIGHT CHAIN; EG.5.1 SPIKE REMARK 245 GLYCOPROTEIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, A REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 PRO H 138 REMARK 465 LEU H 139 REMARK 465 ALA H 140 REMARK 465 PRO H 141 REMARK 465 SER H 142 REMARK 465 SER H 143 REMARK 465 LYS H 144 REMARK 465 SER H 145 REMARK 465 THR H 146 REMARK 465 SER H 147 REMARK 465 GLY H 148 REMARK 465 GLY H 149 REMARK 465 SER H 203 REMARK 465 LEU H 204 REMARK 465 GLY H 205 REMARK 465 THR H 206 REMARK 465 GLN H 207 REMARK 465 LYS H 229 REMARK 465 SER H 230 REMARK 465 CYS H 231 REMARK 465 ASP H 232 REMARK 465 LYS H 233 REMARK 465 THR H 234 REMARK 465 HIS H 235 REMARK 465 THR H 236 REMARK 465 CYS H 237 REMARK 465 PRO H 238 REMARK 465 PRO H 239 REMARK 465 CYS H 240 REMARK 465 PRO H 241 REMARK 465 ALA H 242 REMARK 465 PRO H 243 REMARK 465 GLU H 244 REMARK 465 LEU H 245 REMARK 465 LEU H 246 REMARK 465 GLY H 247 REMARK 465 GLY H 248 REMARK 465 PRO H 249 REMARK 465 SER H 250 REMARK 465 VAL H 251 REMARK 465 PHE H 252 REMARK 465 LEU H 253 REMARK 465 PHE H 254 REMARK 465 PRO H 255 REMARK 465 PRO H 256 REMARK 465 LYS H 257 REMARK 465 PRO H 258 REMARK 465 LYS H 259 REMARK 465 ASP H 260 REMARK 465 THR H 261 REMARK 465 LEU H 262 REMARK 465 MET H 263 REMARK 465 ILE H 264 REMARK 465 SER H 265 REMARK 465 ARG H 266 REMARK 465 THR H 267 REMARK 465 PRO H 268 REMARK 465 GLU H 269 REMARK 465 VAL H 270 REMARK 465 THR H 271 REMARK 465 CYS H 272 REMARK 465 VAL H 273 REMARK 465 VAL H 274 REMARK 465 VAL H 275 REMARK 465 ASP H 276 REMARK 465 VAL H 277 REMARK 465 SER H 278 REMARK 465 HIS H 279 REMARK 465 GLU H 280 REMARK 465 ASP H 281 REMARK 465 PRO H 282 REMARK 465 GLU H 283 REMARK 465 VAL H 284 REMARK 465 LYS H 285 REMARK 465 PHE H 286 REMARK 465 ASN H 287 REMARK 465 TRP H 288 REMARK 465 TYR H 289 REMARK 465 VAL H 290 REMARK 465 ASP H 291 REMARK 465 GLY H 292 REMARK 465 VAL H 293 REMARK 465 GLU H 294 REMARK 465 VAL H 295 REMARK 465 HIS H 296 REMARK 465 ASN H 297 REMARK 465 ALA H 298 REMARK 465 LYS H 299 REMARK 465 THR H 300 REMARK 465 LYS H 301 REMARK 465 PRO H 302 REMARK 465 ARG H 303 REMARK 465 GLU H 304 REMARK 465 GLU H 305 REMARK 465 GLN H 306 REMARK 465 TYR H 307 REMARK 465 ASN H 308 REMARK 465 SER H 309 REMARK 465 THR H 310 REMARK 465 TYR H 311 REMARK 465 ARG H 312 REMARK 465 VAL H 313 REMARK 465 VAL H 314 REMARK 465 SER H 315 REMARK 465 VAL H 316 REMARK 465 LEU H 317 REMARK 465 THR H 318 REMARK 465 VAL H 319 REMARK 465 LEU H 320 REMARK 465 HIS H 321 REMARK 465 GLN H 322 REMARK 465 ASP H 323 REMARK 465 TRP H 324 REMARK 465 LEU H 325 REMARK 465 ASN H 326 REMARK 465 GLY H 327 REMARK 465 LYS H 328 REMARK 465 GLU H 329 REMARK 465 TYR H 330 REMARK 465 LYS H 331 REMARK 465 CYS H 332 REMARK 465 LYS H 333 REMARK 465 VAL H 334 REMARK 465 SER H 335 REMARK 465 ASN H 336 REMARK 465 LYS H 337 REMARK 465 ALA H 338 REMARK 465 LEU H 339 REMARK 465 PRO H 340 REMARK 465 ALA H 341 REMARK 465 PRO H 342 REMARK 465 ILE H 343 REMARK 465 GLU H 344 REMARK 465 LYS H 345 REMARK 465 THR H 346 REMARK 465 ILE H 347 REMARK 465 SER H 348 REMARK 465 LYS H 349 REMARK 465 ALA H 350 REMARK 465 LYS H 351 REMARK 465 GLY H 352 REMARK 465 GLN H 353 REMARK 465 PRO H 354 REMARK 465 ARG H 355 REMARK 465 GLU H 356 REMARK 465 PRO H 357 REMARK 465 GLN H 358 REMARK 465 VAL H 359 REMARK 465 TYR H 360 REMARK 465 THR H 361 REMARK 465 LEU H 362 REMARK 465 PRO H 363 REMARK 465 PRO H 364 REMARK 465 SER H 365 REMARK 465 ARG H 366 REMARK 465 GLU H 367 REMARK 465 GLU H 368 REMARK 465 MET H 369 REMARK 465 THR H 370 REMARK 465 LYS H 371 REMARK 465 ASN H 372 REMARK 465 GLN H 373 REMARK 465 VAL H 374 REMARK 465 SER H 375 REMARK 465 LEU H 376 REMARK 465 THR H 377 REMARK 465 CYS H 378 REMARK 465 LEU H 379 REMARK 465 VAL H 380 REMARK 465 LYS H 381 REMARK 465 GLY H 382 REMARK 465 PHE H 383 REMARK 465 TYR H 384 REMARK 465 PRO H 385 REMARK 465 SER H 386 REMARK 465 ASP H 387 REMARK 465 ILE H 388 REMARK 465 ALA H 389 REMARK 465 VAL H 390 REMARK 465 GLU H 391 REMARK 465 TRP H 392 REMARK 465 GLU H 393 REMARK 465 SER H 394 REMARK 465 ASN H 395 REMARK 465 GLY H 396 REMARK 465 GLN H 397 REMARK 465 PRO H 398 REMARK 465 GLU H 399 REMARK 465 ASN H 400 REMARK 465 ASN H 401 REMARK 465 TYR H 402 REMARK 465 LYS H 403 REMARK 465 THR H 404 REMARK 465 THR H 405 REMARK 465 PRO H 406 REMARK 465 PRO H 407 REMARK 465 VAL H 408 REMARK 465 LEU H 409 REMARK 465 ASP H 410 REMARK 465 SER H 411 REMARK 465 ASP H 412 REMARK 465 GLY H 413 REMARK 465 SER H 414 REMARK 465 PHE H 415 REMARK 465 PHE H 416 REMARK 465 LEU H 417 REMARK 465 TYR H 418 REMARK 465 SER H 419 REMARK 465 LYS H 420 REMARK 465 LEU H 421 REMARK 465 THR H 422 REMARK 465 VAL H 423 REMARK 465 ASP H 424 REMARK 465 LYS H 425 REMARK 465 SER H 426 REMARK 465 ARG H 427 REMARK 465 TRP H 428 REMARK 465 GLN H 429 REMARK 465 GLN H 430 REMARK 465 GLY H 431 REMARK 465 ASN H 432 REMARK 465 VAL H 433 REMARK 465 PHE H 434 REMARK 465 SER H 435 REMARK 465 CYS H 436 REMARK 465 SER H 437 REMARK 465 VAL H 438 REMARK 465 MET H 439 REMARK 465 HIS H 440 REMARK 465 GLU H 441 REMARK 465 ALA H 442 REMARK 465 LEU H 443 REMARK 465 HIS H 444 REMARK 465 ASN H 445 REMARK 465 HIS H 446 REMARK 465 TYR H 447 REMARK 465 THR H 448 REMARK 465 GLN H 449 REMARK 465 LYS H 450 REMARK 465 SER H 451 REMARK 465 LEU H 452 REMARK 465 SER H 453 REMARK 465 LEU H 454 REMARK 465 SER H 455 REMARK 465 PRO H 456 REMARK 465 GLY H 457 REMARK 465 LYS H 458 REMARK 465 ALA L 173 REMARK 465 LEU L 174 REMARK 465 GLN L 175 REMARK 465 SER L 176 REMARK 465 GLU L 233 REMARK 465 CYS L 234 REMARK 465 MET A -6 REMARK 465 PRO A -5 REMARK 465 MET A -4 REMARK 465 GLY A -3 REMARK 465 SER A -2 REMARK 465 LEU A -1 REMARK 465 GLN A 0 REMARK 465 PRO A 1 REMARK 465 LEU A 2 REMARK 465 ALA A 3 REMARK 465 THR A 4 REMARK 465 LEU A 5 REMARK 465 TYR A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 GLY A 9 REMARK 465 MET A 10 REMARK 465 LEU A 11 REMARK 465 VAL A 12 REMARK 465 ALA A 13 REMARK 465 SER A 14 REMARK 465 VAL A 15 REMARK 465 LEU A 16 REMARK 465 ALA A 17 REMARK 465 GLN A 18 REMARK 465 CYS A 19 REMARK 465 VAL A 20 REMARK 465 ASN A 21 REMARK 465 LEU A 22 REMARK 465 ILE A 23 REMARK 465 THR A 24 REMARK 465 ARG A 25 REMARK 465 THR A 26 REMARK 465 GLN A 27 REMARK 465 SER A 28 REMARK 465 TYR A 29 REMARK 465 THR A 30 REMARK 465 ASN A 31 REMARK 465 SER A 32 REMARK 465 PHE A 33 REMARK 465 THR A 34 REMARK 465 ARG A 35 REMARK 465 GLY A 36 REMARK 465 VAL A 37 REMARK 465 TYR A 38 REMARK 465 TYR A 39 REMARK 465 PRO A 40 REMARK 465 ASP A 41 REMARK 465 LYS A 42 REMARK 465 VAL A 43 REMARK 465 PHE A 44 REMARK 465 ARG A 45 REMARK 465 SER A 46 REMARK 465 SER A 47 REMARK 465 VAL A 48 REMARK 465 LEU A 49 REMARK 465 HIS A 50 REMARK 465 SER A 51 REMARK 465 THR A 52 REMARK 465 HIS A 53 REMARK 465 ASP A 54 REMARK 465 LEU A 55 REMARK 465 PHE A 56 REMARK 465 LEU A 57 REMARK 465 PRO A 58 REMARK 465 PHE A 59 REMARK 465 PHE A 60 REMARK 465 SER A 61 REMARK 465 ASN A 62 REMARK 465 VAL A 63 REMARK 465 THR A 64 REMARK 465 TRP A 65 REMARK 465 PHE A 66 REMARK 465 HIS A 67 REMARK 465 ALA A 68 REMARK 465 ILE A 69 REMARK 465 HIS A 70 REMARK 465 VAL A 71 REMARK 465 SER A 72 REMARK 465 GLY A 73 REMARK 465 THR A 74 REMARK 465 ASN A 75 REMARK 465 GLY A 76 REMARK 465 THR A 77 REMARK 465 LYS A 78 REMARK 465 ARG A 79 REMARK 465 PHE A 80 REMARK 465 ASP A 81 REMARK 465 ASN A 82 REMARK 465 PRO A 83 REMARK 465 ALA A 84 REMARK 465 LEU A 85 REMARK 465 PRO A 86 REMARK 465 PHE A 87 REMARK 465 ASN A 88 REMARK 465 ASP A 89 REMARK 465 GLY A 90 REMARK 465 VAL A 91 REMARK 465 TYR A 92 REMARK 465 PHE A 93 REMARK 465 ALA A 94 REMARK 465 SER A 95 REMARK 465 THR A 96 REMARK 465 GLU A 97 REMARK 465 LYS A 98 REMARK 465 SER A 99 REMARK 465 ASN A 100 REMARK 465 ILE A 101 REMARK 465 ILE A 102 REMARK 465 ARG A 103 REMARK 465 GLY A 104 REMARK 465 TRP A 105 REMARK 465 ILE A 106 REMARK 465 PHE A 107 REMARK 465 GLY A 108 REMARK 465 THR A 109 REMARK 465 THR A 110 REMARK 465 LEU A 111 REMARK 465 ASP A 112 REMARK 465 SER A 113 REMARK 465 LYS A 114 REMARK 465 THR A 115 REMARK 465 GLN A 116 REMARK 465 SER A 117 REMARK 465 LEU A 118 REMARK 465 LEU A 119 REMARK 465 ILE A 120 REMARK 465 VAL A 121 REMARK 465 ASN A 122 REMARK 465 ASN A 123 REMARK 465 ALA A 124 REMARK 465 THR A 125 REMARK 465 ASN A 126 REMARK 465 VAL A 127 REMARK 465 VAL A 128 REMARK 465 ILE A 129 REMARK 465 LYS A 130 REMARK 465 VAL A 131 REMARK 465 CYS A 132 REMARK 465 GLU A 133 REMARK 465 PHE A 134 REMARK 465 GLN A 135 REMARK 465 PHE A 136 REMARK 465 CYS A 137 REMARK 465 ASN A 138 REMARK 465 ASP A 139 REMARK 465 PRO A 140 REMARK 465 PHE A 141 REMARK 465 LEU A 142 REMARK 465 ASP A 143 REMARK 465 VAL A 144 REMARK 465 TYR A 145 REMARK 465 GLN A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 MET A 153 REMARK 465 GLU A 154 REMARK 465 SER A 155 REMARK 465 GLU A 156 REMARK 465 PHE A 157 REMARK 465 ARG A 158 REMARK 465 VAL A 159 REMARK 465 TYR A 160 REMARK 465 SER A 161 REMARK 465 SER A 162 REMARK 465 ALA A 163 REMARK 465 ASN A 164 REMARK 465 ASN A 165 REMARK 465 CYS A 166 REMARK 465 THR A 167 REMARK 465 PHE A 168 REMARK 465 GLU A 169 REMARK 465 TYR A 170 REMARK 465 VAL A 171 REMARK 465 SER A 172 REMARK 465 GLN A 173 REMARK 465 PRO A 174 REMARK 465 PHE A 175 REMARK 465 LEU A 176 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLU A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 PHE A 186 REMARK 465 LYS A 187 REMARK 465 ASN A 188 REMARK 465 LEU A 189 REMARK 465 ARG A 190 REMARK 465 GLU A 191 REMARK 465 PHE A 192 REMARK 465 VAL A 193 REMARK 465 PHE A 194 REMARK 465 LYS A 195 REMARK 465 ASN A 196 REMARK 465 ILE A 197 REMARK 465 ASP A 198 REMARK 465 GLY A 199 REMARK 465 TYR A 200 REMARK 465 PHE A 201 REMARK 465 LYS A 202 REMARK 465 ILE A 203 REMARK 465 TYR A 204 REMARK 465 SER A 205 REMARK 465 LYS A 206 REMARK 465 HIS A 207 REMARK 465 THR A 208 REMARK 465 PRO A 209 REMARK 465 ILE A 210 REMARK 465 ASN A 211 REMARK 465 LEU A 212 REMARK 465 GLU A 213 REMARK 465 ARG A 214 REMARK 465 ASP A 215 REMARK 465 LEU A 216 REMARK 465 PRO A 217 REMARK 465 GLN A 218 REMARK 465 GLY A 219 REMARK 465 PHE A 220 REMARK 465 SER A 221 REMARK 465 ALA A 222 REMARK 465 LEU A 223 REMARK 465 GLU A 224 REMARK 465 PRO A 225 REMARK 465 LEU A 226 REMARK 465 VAL A 227 REMARK 465 ASP A 228 REMARK 465 LEU A 229 REMARK 465 PRO A 230 REMARK 465 ILE A 231 REMARK 465 GLY A 232 REMARK 465 ILE A 233 REMARK 465 ASN A 234 REMARK 465 ILE A 235 REMARK 465 THR A 236 REMARK 465 ARG A 237 REMARK 465 PHE A 238 REMARK 465 GLN A 239 REMARK 465 THR A 240 REMARK 465 LEU A 241 REMARK 465 LEU A 242 REMARK 465 ALA A 243 REMARK 465 LEU A 244 REMARK 465 HIS A 245 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 VAL A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 ALA A 262 REMARK 465 ALA A 263 REMARK 465 ALA A 264 REMARK 465 TYR A 265 REMARK 465 TYR A 266 REMARK 465 VAL A 267 REMARK 465 GLY A 268 REMARK 465 TYR A 269 REMARK 465 LEU A 270 REMARK 465 GLN A 271 REMARK 465 PRO A 272 REMARK 465 ARG A 273 REMARK 465 THR A 274 REMARK 465 PHE A 275 REMARK 465 LEU A 276 REMARK 465 LEU A 277 REMARK 465 LYS A 278 REMARK 465 TYR A 279 REMARK 465 ASN A 280 REMARK 465 GLU A 281 REMARK 465 ASN A 282 REMARK 465 GLY A 283 REMARK 465 THR A 284 REMARK 465 ILE A 285 REMARK 465 THR A 286 REMARK 465 ASP A 287 REMARK 465 ALA A 288 REMARK 465 VAL A 289 REMARK 465 ASP A 290 REMARK 465 CYS A 291 REMARK 465 ALA A 292 REMARK 465 LEU A 293 REMARK 465 ASP A 294 REMARK 465 PRO A 295 REMARK 465 LEU A 296 REMARK 465 SER A 297 REMARK 465 GLU A 298 REMARK 465 THR A 299 REMARK 465 LYS A 300 REMARK 465 CYS A 301 REMARK 465 THR A 302 REMARK 465 LEU A 303 REMARK 465 LYS A 304 REMARK 465 SER A 305 REMARK 465 PHE A 306 REMARK 465 THR A 307 REMARK 465 VAL A 308 REMARK 465 GLU A 309 REMARK 465 LYS A 310 REMARK 465 GLY A 311 REMARK 465 ILE A 312 REMARK 465 TYR A 313 REMARK 465 GLN A 314 REMARK 465 THR A 315 REMARK 465 SER A 316 REMARK 465 ASN A 317 REMARK 465 PHE A 318 REMARK 465 ARG A 319 REMARK 465 VAL A 320 REMARK 465 GLN A 321 REMARK 465 PRO A 322 REMARK 465 THR A 323 REMARK 465 GLU A 324 REMARK 465 SER A 325 REMARK 465 ILE A 326 REMARK 465 VAL A 327 REMARK 465 ARG A 328 REMARK 465 PHE A 329 REMARK 465 PRO A 330 REMARK 465 ASN A 331 REMARK 465 ILE A 332 REMARK 465 LYS A 529 REMARK 465 SER A 530 REMARK 465 THR A 531 REMARK 465 ASN A 532 REMARK 465 LEU A 533 REMARK 465 VAL A 534 REMARK 465 LYS A 535 REMARK 465 ASN A 536 REMARK 465 LYS A 537 REMARK 465 CYS A 538 REMARK 465 VAL A 539 REMARK 465 ASN A 540 REMARK 465 PHE A 541 REMARK 465 ASN A 542 REMARK 465 PHE A 543 REMARK 465 ASN A 544 REMARK 465 GLY A 545 REMARK 465 LEU A 546 REMARK 465 THR A 547 REMARK 465 GLY A 548 REMARK 465 THR A 549 REMARK 465 GLY A 550 REMARK 465 VAL A 551 REMARK 465 LEU A 552 REMARK 465 THR A 553 REMARK 465 GLU A 554 REMARK 465 SER A 555 REMARK 465 ASN A 556 REMARK 465 LYS A 557 REMARK 465 LYS A 558 REMARK 465 PHE A 559 REMARK 465 LEU A 560 REMARK 465 PRO A 561 REMARK 465 PHE A 562 REMARK 465 GLN A 563 REMARK 465 GLN A 564 REMARK 465 PHE A 565 REMARK 465 GLY A 566 REMARK 465 ARG A 567 REMARK 465 ASP A 568 REMARK 465 ILE A 569 REMARK 465 ALA A 570 REMARK 465 ASP A 571 REMARK 465 THR A 572 REMARK 465 THR A 573 REMARK 465 ASP A 574 REMARK 465 ALA A 575 REMARK 465 VAL A 576 REMARK 465 ARG A 577 REMARK 465 ASP A 578 REMARK 465 PRO A 579 REMARK 465 GLN A 580 REMARK 465 THR A 581 REMARK 465 LEU A 582 REMARK 465 GLU A 583 REMARK 465 ILE A 584 REMARK 465 LEU A 585 REMARK 465 ASP A 586 REMARK 465 ILE A 587 REMARK 465 THR A 588 REMARK 465 PRO A 589 REMARK 465 CYS A 590 REMARK 465 SER A 591 REMARK 465 PHE A 592 REMARK 465 GLY A 593 REMARK 465 GLY A 594 REMARK 465 VAL A 595 REMARK 465 SER A 596 REMARK 465 VAL A 597 REMARK 465 ILE A 598 REMARK 465 THR A 599 REMARK 465 PRO A 600 REMARK 465 GLY A 601 REMARK 465 THR A 602 REMARK 465 ASN A 603 REMARK 465 THR A 604 REMARK 465 SER A 605 REMARK 465 ASN A 606 REMARK 465 GLN A 607 REMARK 465 VAL A 608 REMARK 465 ALA A 609 REMARK 465 VAL A 610 REMARK 465 LEU A 611 REMARK 465 TYR A 612 REMARK 465 GLN A 613 REMARK 465 GLY A 614 REMARK 465 VAL A 615 REMARK 465 ASN A 616 REMARK 465 CYS A 617 REMARK 465 THR A 618 REMARK 465 GLU A 619 REMARK 465 VAL A 620 REMARK 465 PRO A 621 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 SER A 640 REMARK 465 ASN A 641 REMARK 465 VAL A 642 REMARK 465 PHE A 643 REMARK 465 GLN A 644 REMARK 465 THR A 645 REMARK 465 ARG A 646 REMARK 465 ALA A 647 REMARK 465 GLY A 648 REMARK 465 CYS A 649 REMARK 465 LEU A 650 REMARK 465 ILE A 651 REMARK 465 GLY A 652 REMARK 465 ALA A 653 REMARK 465 GLU A 654 REMARK 465 TYR A 655 REMARK 465 VAL A 656 REMARK 465 ASN A 657 REMARK 465 ASN A 658 REMARK 465 SER A 659 REMARK 465 TYR A 660 REMARK 465 GLU A 661 REMARK 465 CYS A 662 REMARK 465 ASP A 663 REMARK 465 ILE A 664 REMARK 465 PRO A 665 REMARK 465 ILE A 666 REMARK 465 GLY A 667 REMARK 465 ALA A 668 REMARK 465 GLY A 669 REMARK 465 ILE A 670 REMARK 465 CYS A 671 REMARK 465 ALA A 672 REMARK 465 SER A 673 REMARK 465 TYR A 674 REMARK 465 GLN A 675 REMARK 465 THR A 676 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 LYS A 679 REMARK 465 SER A 680 REMARK 465 HIS A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 SER A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 SER A 689 REMARK 465 GLN A 690 REMARK 465 SER A 691 REMARK 465 ILE A 692 REMARK 465 ILE A 693 REMARK 465 ALA A 694 REMARK 465 TYR A 695 REMARK 465 THR A 696 REMARK 465 MET A 697 REMARK 465 SER A 698 REMARK 465 LEU A 699 REMARK 465 GLY A 700 REMARK 465 ALA A 701 REMARK 465 GLU A 702 REMARK 465 ASN A 703 REMARK 465 SER A 704 REMARK 465 VAL A 705 REMARK 465 ALA A 706 REMARK 465 TYR A 707 REMARK 465 SER A 708 REMARK 465 ASN A 709 REMARK 465 ASN A 710 REMARK 465 SER A 711 REMARK 465 ILE A 712 REMARK 465 ALA A 713 REMARK 465 ILE A 714 REMARK 465 PRO A 715 REMARK 465 THR A 716 REMARK 465 ASN A 717 REMARK 465 PHE A 718 REMARK 465 THR A 719 REMARK 465 ILE A 720 REMARK 465 SER A 721 REMARK 465 VAL A 722 REMARK 465 THR A 723 REMARK 465 THR A 724 REMARK 465 GLU A 725 REMARK 465 ILE A 726 REMARK 465 LEU A 727 REMARK 465 PRO A 728 REMARK 465 VAL A 729 REMARK 465 SER A 730 REMARK 465 MET A 731 REMARK 465 THR A 732 REMARK 465 LYS A 733 REMARK 465 THR A 734 REMARK 465 SER A 735 REMARK 465 VAL A 736 REMARK 465 ASP A 737 REMARK 465 CYS A 738 REMARK 465 THR A 739 REMARK 465 MET A 740 REMARK 465 TYR A 741 REMARK 465 ILE A 742 REMARK 465 CYS A 743 REMARK 465 GLY A 744 REMARK 465 ASP A 745 REMARK 465 SER A 746 REMARK 465 THR A 747 REMARK 465 GLU A 748 REMARK 465 CYS A 749 REMARK 465 SER A 750 REMARK 465 ASN A 751 REMARK 465 LEU A 752 REMARK 465 LEU A 753 REMARK 465 LEU A 754 REMARK 465 GLN A 755 REMARK 465 TYR A 756 REMARK 465 GLY A 757 REMARK 465 SER A 758 REMARK 465 PHE A 759 REMARK 465 CYS A 760 REMARK 465 THR A 761 REMARK 465 GLN A 762 REMARK 465 LEU A 763 REMARK 465 LYS A 764 REMARK 465 ARG A 765 REMARK 465 ALA A 766 REMARK 465 LEU A 767 REMARK 465 THR A 768 REMARK 465 GLY A 769 REMARK 465 ILE A 770 REMARK 465 ALA A 771 REMARK 465 VAL A 772 REMARK 465 GLU A 773 REMARK 465 GLN A 774 REMARK 465 ASP A 775 REMARK 465 LYS A 776 REMARK 465 ASN A 777 REMARK 465 THR A 778 REMARK 465 GLN A 779 REMARK 465 GLU A 780 REMARK 465 VAL A 781 REMARK 465 PHE A 782 REMARK 465 ALA A 783 REMARK 465 GLN A 784 REMARK 465 VAL A 785 REMARK 465 LYS A 786 REMARK 465 GLN A 787 REMARK 465 ILE A 788 REMARK 465 TYR A 789 REMARK 465 LYS A 790 REMARK 465 THR A 791 REMARK 465 PRO A 792 REMARK 465 PRO A 793 REMARK 465 ILE A 794 REMARK 465 LYS A 795 REMARK 465 TYR A 796 REMARK 465 PHE A 797 REMARK 465 GLY A 798 REMARK 465 GLY A 799 REMARK 465 PHE A 800 REMARK 465 ASN A 801 REMARK 465 PHE A 802 REMARK 465 SER A 803 REMARK 465 GLN A 804 REMARK 465 ILE A 805 REMARK 465 LEU A 806 REMARK 465 PRO A 807 REMARK 465 ASP A 808 REMARK 465 PRO A 809 REMARK 465 SER A 810 REMARK 465 LYS A 811 REMARK 465 PRO A 812 REMARK 465 SER A 813 REMARK 465 LYS A 814 REMARK 465 ARG A 815 REMARK 465 SER A 816 REMARK 465 PRO A 817 REMARK 465 ILE A 818 REMARK 465 GLU A 819 REMARK 465 ASP A 820 REMARK 465 LEU A 821 REMARK 465 LEU A 822 REMARK 465 PHE A 823 REMARK 465 ASN A 824 REMARK 465 LYS A 825 REMARK 465 VAL A 826 REMARK 465 THR A 827 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 LYS A 854 REMARK 465 PHE A 855 REMARK 465 ASN A 856 REMARK 465 GLY A 857 REMARK 465 LEU A 858 REMARK 465 THR A 859 REMARK 465 VAL A 860 REMARK 465 LEU A 861 REMARK 465 PRO A 862 REMARK 465 PRO A 863 REMARK 465 LEU A 864 REMARK 465 LEU A 865 REMARK 465 THR A 866 REMARK 465 ASP A 867 REMARK 465 GLU A 868 REMARK 465 MET A 869 REMARK 465 ILE A 870 REMARK 465 ALA A 871 REMARK 465 GLN A 872 REMARK 465 TYR A 873 REMARK 465 THR A 874 REMARK 465 SER A 875 REMARK 465 ALA A 876 REMARK 465 LEU A 877 REMARK 465 LEU A 878 REMARK 465 ALA A 879 REMARK 465 GLY A 880 REMARK 465 THR A 881 REMARK 465 ILE A 882 REMARK 465 THR A 883 REMARK 465 SER A 884 REMARK 465 GLY A 885 REMARK 465 TRP A 886 REMARK 465 THR A 887 REMARK 465 PHE A 888 REMARK 465 GLY A 889 REMARK 465 ALA A 890 REMARK 465 GLY A 891 REMARK 465 PRO A 892 REMARK 465 ALA A 893 REMARK 465 LEU A 894 REMARK 465 GLN A 895 REMARK 465 ILE A 896 REMARK 465 PRO A 897 REMARK 465 PHE A 898 REMARK 465 PRO A 899 REMARK 465 MET A 900 REMARK 465 GLN A 901 REMARK 465 MET A 902 REMARK 465 ALA A 903 REMARK 465 TYR A 904 REMARK 465 ARG A 905 REMARK 465 PHE A 906 REMARK 465 ASN A 907 REMARK 465 GLY A 908 REMARK 465 ILE A 909 REMARK 465 GLY A 910 REMARK 465 VAL A 911 REMARK 465 THR A 912 REMARK 465 GLN A 913 REMARK 465 ASN A 914 REMARK 465 VAL A 915 REMARK 465 LEU A 916 REMARK 465 TYR A 917 REMARK 465 GLU A 918 REMARK 465 ASN A 919 REMARK 465 GLN A 920 REMARK 465 LYS A 921 REMARK 465 LEU A 922 REMARK 465 ILE A 923 REMARK 465 ALA A 924 REMARK 465 ASN A 925 REMARK 465 GLN A 926 REMARK 465 PHE A 927 REMARK 465 ASN A 928 REMARK 465 SER A 929 REMARK 465 ALA A 930 REMARK 465 ILE A 931 REMARK 465 GLY A 932 REMARK 465 LYS A 933 REMARK 465 ILE A 934 REMARK 465 GLN A 935 REMARK 465 ASP A 936 REMARK 465 SER A 937 REMARK 465 LEU A 938 REMARK 465 SER A 939 REMARK 465 SER A 940 REMARK 465 THR A 941 REMARK 465 PRO A 942 REMARK 465 SER A 943 REMARK 465 ALA A 944 REMARK 465 LEU A 945 REMARK 465 GLY A 946 REMARK 465 LYS A 947 REMARK 465 LEU A 948 REMARK 465 GLN A 949 REMARK 465 ASP A 950 REMARK 465 VAL A 951 REMARK 465 VAL A 952 REMARK 465 ASN A 953 REMARK 465 HIS A 954 REMARK 465 ASN A 955 REMARK 465 ALA A 956 REMARK 465 GLN A 957 REMARK 465 ALA A 958 REMARK 465 LEU A 959 REMARK 465 ASN A 960 REMARK 465 THR A 961 REMARK 465 LEU A 962 REMARK 465 VAL A 963 REMARK 465 LYS A 964 REMARK 465 GLN A 965 REMARK 465 LEU A 966 REMARK 465 SER A 967 REMARK 465 SER A 968 REMARK 465 LYS A 969 REMARK 465 PHE A 970 REMARK 465 GLY A 971 REMARK 465 ALA A 972 REMARK 465 ILE A 973 REMARK 465 SER A 974 REMARK 465 SER A 975 REMARK 465 VAL A 976 REMARK 465 LEU A 977 REMARK 465 ASN A 978 REMARK 465 ASP A 979 REMARK 465 ILE A 980 REMARK 465 LEU A 981 REMARK 465 SER A 982 REMARK 465 ARG A 983 REMARK 465 LEU A 984 REMARK 465 ASP A 985 REMARK 465 PRO A 986 REMARK 465 PRO A 987 REMARK 465 GLU A 988 REMARK 465 ALA A 989 REMARK 465 GLU A 990 REMARK 465 VAL A 991 REMARK 465 GLN A 992 REMARK 465 ILE A 993 REMARK 465 ASP A 994 REMARK 465 ARG A 995 REMARK 465 LEU A 996 REMARK 465 ILE A 997 REMARK 465 THR A 998 REMARK 465 GLY A 999 REMARK 465 ARG A 1000 REMARK 465 LEU A 1001 REMARK 465 GLN A 1002 REMARK 465 SER A 1003 REMARK 465 LEU A 1004 REMARK 465 GLN A 1005 REMARK 465 THR A 1006 REMARK 465 TYR A 1007 REMARK 465 VAL A 1008 REMARK 465 THR A 1009 REMARK 465 GLN A 1010 REMARK 465 GLN A 1011 REMARK 465 LEU A 1012 REMARK 465 ILE A 1013 REMARK 465 ARG A 1014 REMARK 465 ALA A 1015 REMARK 465 ALA A 1016 REMARK 465 GLU A 1017 REMARK 465 ILE A 1018 REMARK 465 ARG A 1019 REMARK 465 ALA A 1020 REMARK 465 SER A 1021 REMARK 465 ALA A 1022 REMARK 465 ASN A 1023 REMARK 465 LEU A 1024 REMARK 465 ALA A 1025 REMARK 465 ALA A 1026 REMARK 465 THR A 1027 REMARK 465 LYS A 1028 REMARK 465 MET A 1029 REMARK 465 SER A 1030 REMARK 465 GLU A 1031 REMARK 465 CYS A 1032 REMARK 465 VAL A 1033 REMARK 465 LEU A 1034 REMARK 465 GLY A 1035 REMARK 465 GLN A 1036 REMARK 465 SER A 1037 REMARK 465 LYS A 1038 REMARK 465 ARG A 1039 REMARK 465 VAL A 1040 REMARK 465 ASP A 1041 REMARK 465 PHE A 1042 REMARK 465 CYS A 1043 REMARK 465 GLY A 1044 REMARK 465 LYS A 1045 REMARK 465 GLY A 1046 REMARK 465 TYR A 1047 REMARK 465 HIS A 1048 REMARK 465 LEU A 1049 REMARK 465 MET A 1050 REMARK 465 SER A 1051 REMARK 465 PHE A 1052 REMARK 465 PRO A 1053 REMARK 465 GLN A 1054 REMARK 465 SER A 1055 REMARK 465 ALA A 1056 REMARK 465 PRO A 1057 REMARK 465 HIS A 1058 REMARK 465 GLY A 1059 REMARK 465 VAL A 1060 REMARK 465 VAL A 1061 REMARK 465 PHE A 1062 REMARK 465 LEU A 1063 REMARK 465 HIS A 1064 REMARK 465 VAL A 1065 REMARK 465 THR A 1066 REMARK 465 TYR A 1067 REMARK 465 VAL A 1068 REMARK 465 PRO A 1069 REMARK 465 ALA A 1070 REMARK 465 GLN A 1071 REMARK 465 GLU A 1072 REMARK 465 LYS A 1073 REMARK 465 ASN A 1074 REMARK 465 PHE A 1075 REMARK 465 THR A 1076 REMARK 465 THR A 1077 REMARK 465 ALA A 1078 REMARK 465 PRO A 1079 REMARK 465 ALA A 1080 REMARK 465 ILE A 1081 REMARK 465 CYS A 1082 REMARK 465 HIS A 1083 REMARK 465 ASP A 1084 REMARK 465 GLY A 1085 REMARK 465 LYS A 1086 REMARK 465 ALA A 1087 REMARK 465 HIS A 1088 REMARK 465 PHE A 1089 REMARK 465 PRO A 1090 REMARK 465 ARG A 1091 REMARK 465 GLU A 1092 REMARK 465 GLY A 1093 REMARK 465 VAL A 1094 REMARK 465 PHE A 1095 REMARK 465 VAL A 1096 REMARK 465 SER A 1097 REMARK 465 ASN A 1098 REMARK 465 GLY A 1099 REMARK 465 THR A 1100 REMARK 465 HIS A 1101 REMARK 465 TRP A 1102 REMARK 465 PHE A 1103 REMARK 465 VAL A 1104 REMARK 465 THR A 1105 REMARK 465 GLN A 1106 REMARK 465 ARG A 1107 REMARK 465 ASN A 1108 REMARK 465 PHE A 1109 REMARK 465 TYR A 1110 REMARK 465 GLU A 1111 REMARK 465 PRO A 1112 REMARK 465 GLN A 1113 REMARK 465 ILE A 1114 REMARK 465 ILE A 1115 REMARK 465 THR A 1116 REMARK 465 THR A 1117 REMARK 465 ASP A 1118 REMARK 465 ASN A 1119 REMARK 465 THR A 1120 REMARK 465 PHE A 1121 REMARK 465 VAL A 1122 REMARK 465 SER A 1123 REMARK 465 GLY A 1124 REMARK 465 ASN A 1125 REMARK 465 CYS A 1126 REMARK 465 ASP A 1127 REMARK 465 VAL A 1128 REMARK 465 VAL A 1129 REMARK 465 ILE A 1130 REMARK 465 GLY A 1131 REMARK 465 ILE A 1132 REMARK 465 VAL A 1133 REMARK 465 ASN A 1134 REMARK 465 ASN A 1135 REMARK 465 THR A 1136 REMARK 465 VAL A 1137 REMARK 465 TYR A 1138 REMARK 465 ASP A 1139 REMARK 465 PRO A 1140 REMARK 465 LEU A 1141 REMARK 465 GLN A 1142 REMARK 465 PRO A 1143 REMARK 465 GLU A 1144 REMARK 465 LEU A 1145 REMARK 465 ASP A 1146 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 GLY A 1209 REMARK 465 SER A 1210 REMARK 465 GLY A 1211 REMARK 465 TYR A 1212 REMARK 465 ILE A 1213 REMARK 465 PRO A 1214 REMARK 465 GLU A 1215 REMARK 465 ALA A 1216 REMARK 465 PRO A 1217 REMARK 465 ARG A 1218 REMARK 465 ASP A 1219 REMARK 465 GLY A 1220 REMARK 465 GLN A 1221 REMARK 465 ALA A 1222 REMARK 465 TYR A 1223 REMARK 465 VAL A 1224 REMARK 465 ARG A 1225 REMARK 465 LYS A 1226 REMARK 465 ASP A 1227 REMARK 465 GLY A 1228 REMARK 465 GLU A 1229 REMARK 465 TRP A 1230 REMARK 465 VAL A 1231 REMARK 465 PHE A 1232 REMARK 465 LEU A 1233 REMARK 465 SER A 1234 REMARK 465 THR A 1235 REMARK 465 PHE A 1236 REMARK 465 LEU A 1237 REMARK 465 SER A 1238 REMARK 465 GLY A 1239 REMARK 465 LEU A 1240 REMARK 465 GLU A 1241 REMARK 465 VAL A 1242 REMARK 465 LEU A 1243 REMARK 465 PHE A 1244 REMARK 465 GLN A 1245 REMARK 465 GLY A 1246 REMARK 465 PRO A 1247 REMARK 465 GLY A 1248 REMARK 465 GLY A 1249 REMARK 465 TRP A 1250 REMARK 465 SER A 1251 REMARK 465 HIS A 1252 REMARK 465 PRO A 1253 REMARK 465 GLN A 1254 REMARK 465 PHE A 1255 REMARK 465 GLU A 1256 REMARK 465 LYS A 1257 REMARK 465 GLY A 1258 REMARK 465 GLY A 1259 REMARK 465 GLY A 1260 REMARK 465 SER A 1261 REMARK 465 GLY A 1262 REMARK 465 GLY A 1263 REMARK 465 GLY A 1264 REMARK 465 SER A 1265 REMARK 465 GLY A 1266 REMARK 465 GLY A 1267 REMARK 465 SER A 1268 REMARK 465 ALA A 1269 REMARK 465 TRP A 1270 REMARK 465 SER A 1271 REMARK 465 HIS A 1272 REMARK 465 PRO A 1273 REMARK 465 GLN A 1274 REMARK 465 PHE A 1275 REMARK 465 GLU A 1276 REMARK 465 LYS A 1277 REMARK 465 GLY A 1278 REMARK 465 GLY A 1279 REMARK 465 SER A 1280 REMARK 465 HIS A 1281 REMARK 465 HIS A 1282 REMARK 465 HIS A 1283 REMARK 465 HIS A 1284 REMARK 465 HIS A 1285 REMARK 465 HIS A 1286 REMARK 465 HIS A 1287 REMARK 465 HIS A 1288 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LYS H 84 -4.30 68.50 REMARK 500 PRO L 46 47.69 -73.40 REMARK 500 LYS L 48 -168.22 -160.92 REMARK 500 ALA L 57 -4.68 68.59 REMARK 500 SER L 65 -3.76 -140.94 REMARK 500 SER L 77 34.87 -97.09 REMARK 500 ALA L 204 -4.51 68.06 REMARK 500 THR A 345 -9.06 70.42 REMARK 500 ALA A 363 -167.64 -166.65 REMARK 500 TYR A 380 -159.86 -141.65 REMARK 500 SER A 408 -165.51 -79.38 REMARK 500 ASN A 450 -4.89 75.74 REMARK 500 ARG A 457 34.52 -140.50 REMARK 500 ASN A 487 -4.36 69.70 REMARK 500 ARG A 498 59.85 -144.39 REMARK 500 LEU A 518 -169.60 -126.04 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-62660 RELATED DB: EMDB REMARK 900 THE LOCAL REFINED MAP OF SARS-COV-2 EG.5.1 VARIANT SPIKE PROTEIN REMARK 900 COMPLEXED WITH ANTIBODY XGI-171 REMARK 900 RELATED ID: EMD-62680 RELATED DB: EMDB REMARK 900 RELATED ID: 9KZZ RELATED DB: PDB DBREF 9KZD H 1 458 PDB 9KZD 9KZD 1 458 DBREF 9KZD L 1 234 PDB 9KZD 9KZD 1 234 DBREF 9KZD A 18 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 SEQADV 9KZD MET A -6 UNP P0DTC2 INITIATING METHIONINE SEQADV 9KZD PRO A -5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD MET A -4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A -3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLN A 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PRO A 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ALA A 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD THR A 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD TYR A 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD MET A 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD VAL A 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ALA A 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 14 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD VAL A 15 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 16 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ALA A 17 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ILE A 23 UNP P0DTC2 THR 19 VARIANT SEQADV 9KZD A UNP P0DTC2 LEU 24 DELETION SEQADV 9KZD A UNP P0DTC2 PRO 25 DELETION SEQADV 9KZD A UNP P0DTC2 PRO 26 DELETION SEQADV 9KZD SER A 28 UNP P0DTC2 ALA 27 VARIANT SEQADV 9KZD HIS A 53 UNP P0DTC2 GLN 52 VARIANT SEQADV 9KZD ALA A 84 UNP P0DTC2 VAL 83 VARIANT SEQADV 9KZD ASP A 143 UNP P0DTC2 GLY 142 VARIANT SEQADV 9KZD A UNP P0DTC2 TYR 144 DELETION SEQADV 9KZD GLN A 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 9KZD GLU A 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 9KZD GLU A 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 9KZD VAL A 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 9KZD HIS A 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 9KZD THR A 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 9KZD ILE A 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 9KZD PHE A 371 UNP P0DTC2 SER 371 VARIANT SEQADV 9KZD PRO A 373 UNP P0DTC2 SER 373 VARIANT SEQADV 9KZD PHE A 375 UNP P0DTC2 SER 375 VARIANT SEQADV 9KZD ALA A 376 UNP P0DTC2 THR 376 VARIANT SEQADV 9KZD ASN A 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 9KZD SER A 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 9KZD ASN A 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 9KZD LYS A 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 9KZD PRO A 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 9KZD SER A 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 9KZD LEU A 456 UNP P0DTC2 PHE 456 VARIANT SEQADV 9KZD LYS A 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 9KZD ASN A 477 UNP P0DTC2 SER 477 VARIANT SEQADV 9KZD LYS A 478 UNP P0DTC2 THR 478 VARIANT SEQADV 9KZD ALA A 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 9KZD PRO A 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 9KZD SER A 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 9KZD ARG A 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 9KZD TYR A 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 9KZD HIS A 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 9KZD GLY A 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 9KZD TYR A 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 9KZD LYS A 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 9KZD HIS A 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 9KZD GLY A 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9KZD SER A 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9KZD SER A 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9KZD LYS A 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 9KZD TYR A 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 9KZD PRO A 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9KZD PRO A 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9KZD PRO A 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9KZD PRO A 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9KZD HIS A 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 9KZD LYS A 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 9KZD PRO A 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 9KZD PRO A 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 9KZD GLY A 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD TYR A 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ILE A 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PRO A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLU A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ALA A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PRO A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ARG A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ASP A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLN A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ALA A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD TYR A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD VAL A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ARG A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LYS A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ASP A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLU A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD TRP A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD VAL A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PHE A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD THR A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PHE A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLU A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD VAL A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LEU A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PHE A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLN A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PRO A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD TRP A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PRO A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLN A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PHE A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLU A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LYS A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD ALA A 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD TRP A 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PRO A 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLN A 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD PHE A 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLU A 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD LYS A 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD GLY A 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD SER A 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZD HIS A 1288 UNP P0DTC2 EXPRESSION TAG SEQRES 1 H 449 GLU VAL GLN LEU ALA GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 H 449 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 H 449 PHE THR PHE SER THR TYR ASP MET HIS TRP VAL ARG GLN SEQRES 4 H 449 VAL THR GLY ASN GLY LEU GLU TRP VAL SER THR ILE GLY SEQRES 5 H 449 THR GLY GLY ASP THR TYR TYR SER ASP SER VAL LYS GLY SEQRES 6 H 449 ARG PHE THR VAL SER ARG GLU ASN ALA LYS ASN ALA LEU SEQRES 7 H 449 PHE LEU GLN ILE ASN GLY LEU ARG ALA GLY ASP THR ALA SEQRES 8 H 449 VAL TYR TYR CYS ALA ARG GLY GLY SER GLY GLN PHE TRP SEQRES 9 H 449 TYR PHE ASP LEU TRP GLY ARG GLY THR LEU VAL THR VAL SEQRES 10 H 449 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 H 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 H 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 H 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 H 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 H 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 H 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 H 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 H 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 H 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 H 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 H 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 H 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 H 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 H 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 H 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 H 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 H 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 H 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 H 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 H 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 H 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 H 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 H 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 H 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 H 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 L 215 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 215 SER LEU GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 215 GLN THR ILE GLY ARG PHE LEU ASN TRP TYR GLN GLN LYS SEQRES 4 L 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR GLY ALA SER SEQRES 5 L 215 SER LEU GLN ILE GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 215 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 L 215 TYR SER MET PRO PRO VAL THR PHE GLY GLN GLY THR ARG SEQRES 9 L 215 LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 A 1295 MET PRO MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR SEQRES 2 A 1295 LEU LEU GLY MET LEU VAL ALA SER VAL LEU ALA GLN CYS SEQRES 3 A 1295 VAL ASN LEU ILE THR ARG THR GLN SER TYR THR ASN SER SEQRES 4 A 1295 PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SEQRES 5 A 1295 SER SER VAL LEU HIS SER THR HIS ASP LEU PHE LEU PRO SEQRES 6 A 1295 PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SEQRES 7 A 1295 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO ALA SEQRES 8 A 1295 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 9 A 1295 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 10 A 1295 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 11 A 1295 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 12 A 1295 CYS ASN ASP PRO PHE LEU ASP VAL TYR GLN LYS ASN ASN SEQRES 13 A 1295 LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SER SEQRES 14 A 1295 ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO PHE SEQRES 15 A 1295 LEU MET ASP LEU GLU GLY LYS GLU GLY ASN PHE LYS ASN SEQRES 16 A 1295 LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE SEQRES 17 A 1295 LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU GLU ARG SEQRES 18 A 1295 ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU VAL SEQRES 19 A 1295 ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN THR SEQRES 20 A 1295 LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO VAL ASP SEQRES 21 A 1295 SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR TYR SEQRES 22 A 1295 VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS TYR SEQRES 23 A 1295 ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS ALA SEQRES 24 A 1295 LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SER SEQRES 25 A 1295 PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN PHE SEQRES 26 A 1295 ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO ASN SEQRES 27 A 1295 ILE THR ASN LEU CYS PRO PHE HIS GLU VAL PHE ASN ALA SEQRES 28 A 1295 THR THR PHE ALA SER VAL TYR ALA TRP ASN ARG LYS ARG SEQRES 29 A 1295 ILE SER ASN CYS VAL ALA ASP TYR SER VAL ILE TYR ASN SEQRES 30 A 1295 PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SER SEQRES 31 A 1295 PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL TYR SEQRES 32 A 1295 ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER GLN SEQRES 33 A 1295 ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR ASN SEQRES 34 A 1295 TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE ALA SEQRES 35 A 1295 TRP ASN SER ASN LYS LEU ASP SER LYS PRO SER GLY ASN SEQRES 36 A 1295 TYR ASN TYR LEU TYR ARG LEU LEU ARG LYS SER LYS LEU SEQRES 37 A 1295 LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR GLN SEQRES 38 A 1295 ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY PRO ASN SEQRES 39 A 1295 CYS TYR SER PRO LEU GLN SER TYR GLY PHE ARG PRO THR SEQRES 40 A 1295 TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL LEU SEQRES 41 A 1295 SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS GLY SEQRES 42 A 1295 PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS VAL SEQRES 43 A 1295 ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL LEU SEQRES 44 A 1295 THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE SEQRES 45 A 1295 GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG ASP SEQRES 46 A 1295 PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SER SEQRES 47 A 1295 PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN THR SEQRES 48 A 1295 SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS SEQRES 49 A 1295 THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU THR SEQRES 50 A 1295 PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL PHE SEQRES 51 A 1295 GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR VAL SEQRES 52 A 1295 ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY SEQRES 53 A 1295 ILE CYS ALA SER TYR GLN THR GLN THR LYS SER HIS GLY SEQRES 54 A 1295 SER ALA SER SER VAL ALA SER GLN SER ILE ILE ALA TYR SEQRES 55 A 1295 THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SER SEQRES 56 A 1295 ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SER SEQRES 57 A 1295 VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS THR SEQRES 58 A 1295 SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER THR SEQRES 59 A 1295 GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE CYS SEQRES 60 A 1295 THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL GLU SEQRES 61 A 1295 GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL LYS SEQRES 62 A 1295 GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY GLY SEQRES 63 A 1295 PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS PRO SEQRES 64 A 1295 SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN LYS SEQRES 65 A 1295 VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY SEQRES 66 A 1295 ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS SEQRES 67 A 1295 ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO LEU SEQRES 68 A 1295 LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA LEU SEQRES 69 A 1295 LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY ALA SEQRES 70 A 1295 GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET ALA SEQRES 71 A 1295 TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL LEU SEQRES 72 A 1295 TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SER SEQRES 73 A 1295 ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR PRO SEQRES 74 A 1295 SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS ASN SEQRES 75 A 1295 ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SER SEQRES 76 A 1295 LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE LEU SEQRES 77 A 1295 SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP SEQRES 78 A 1295 ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR TYR SEQRES 79 A 1295 VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SEQRES 80 A 1295 SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS VAL SEQRES 81 A 1295 LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS GLY SEQRES 82 A 1295 TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS GLY SEQRES 83 A 1295 VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN GLU SEQRES 84 A 1295 LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP GLY SEQRES 85 A 1295 LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER ASN SEQRES 86 A 1295 GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR GLU SEQRES 87 A 1295 PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER GLY SEQRES 88 A 1295 ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR VAL SEQRES 89 A 1295 TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS GLU SEQRES 90 A 1295 GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO ASP SEQRES 91 A 1295 VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER VAL SEQRES 92 A 1295 VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL SEQRES 93 A 1295 ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN GLU SEQRES 94 A 1295 LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO GLU SEQRES 95 A 1295 ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY SEQRES 96 A 1295 GLU TRP VAL PHE LEU SER THR PHE LEU SER GLY LEU GLU SEQRES 97 A 1295 VAL LEU PHE GLN GLY PRO GLY GLY TRP SER HIS PRO GLN SEQRES 98 A 1295 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY SEQRES 99 A 1295 SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SER SEQRES 100 A 1295 HIS HIS HIS HIS HIS HIS HIS HIS HELIX 1 AA1 THR H 29 TYR H 37 5 5 HELIX 2 AA2 ASN H 82 LYS H 84 5 3 HELIX 3 AA3 ARG H 95 ASP H 98 5 4 HELIX 4 AA4 LYS H 216 ASN H 219 5 4 HELIX 5 AA5 SER L 141 LYS L 146 1 6 HELIX 6 AA6 ALA L 204 HIS L 209 1 6 HELIX 7 AA7 PRO A 337 VAL A 341 5 5 HELIX 8 AA8 TYR A 365 ASN A 370 1 6 HELIX 9 AA9 LYS A 386 LEU A 390 5 5 HELIX 10 AB1 ASN A 405 VAL A 407 5 3 HELIX 11 AB2 GLY A 416 ASN A 422 1 7 HELIX 12 AB3 PRO A 479 VAL A 483 5 5 SHEET 1 AA1 6 GLY H 11 VAL H 13 0 SHEET 2 AA1 6 THR H 122 VAL H 126 1 O THR H 125 N VAL H 13 SHEET 3 AA1 6 ALA H 100 GLY H 107 -1 N TYR H 102 O THR H 122 SHEET 4 AA1 6 ASP H 38 VAL H 45 -1 N ASP H 38 O GLY H 107 SHEET 5 AA1 6 LEU H 50 ILE H 56 -1 O SER H 54 N TRP H 41 SHEET 6 AA1 6 THR H 65 TYR H 67 -1 O TYR H 66 N THR H 55 SHEET 1 AA2 4 GLY H 11 VAL H 13 0 SHEET 2 AA2 4 THR H 122 VAL H 126 1 O THR H 125 N VAL H 13 SHEET 3 AA2 4 ALA H 100 GLY H 107 -1 N TYR H 102 O THR H 122 SHEET 4 AA2 4 PHE H 115 TRP H 118 -1 O ASP H 116 N ARG H 106 SHEET 1 AA3 3 LEU H 19 ALA H 24 0 SHEET 2 AA3 3 ALA H 86 ILE H 91 -1 O LEU H 87 N CYS H 23 SHEET 3 AA3 3 PHE H 76 GLU H 81 -1 N SER H 79 O PHE H 88 SHEET 1 AA4 3 ALA H 151 GLY H 154 0 SHEET 2 AA4 3 VAL H 196 VAL H 199 -1 O VAL H 199 N ALA H 151 SHEET 3 AA4 3 VAL H 178 HIS H 179 -1 N HIS H 179 O VAL H 196 SHEET 1 AA5 3 VAL H 157 TYR H 160 0 SHEET 2 AA5 3 TYR H 191 LEU H 193 -1 O TYR H 191 N TYR H 160 SHEET 3 AA5 3 VAL H 184 LEU H 185 -1 N VAL H 184 O SER H 192 SHEET 1 AA6 2 ILE H 210 HIS H 215 0 SHEET 2 AA6 2 THR H 220 ARG H 225 -1 O LYS H 224 N CYS H 211 SHEET 1 AA7 5 SER L 10 ALA L 13 0 SHEET 2 AA7 5 THR L 122 ILE L 126 1 O GLU L 125 N ALA L 13 SHEET 3 AA7 5 THR L 101 GLN L 106 -1 N TYR L 102 O THR L 122 SHEET 4 AA7 5 LEU L 39 GLN L 44 -1 N GLN L 44 O THR L 101 SHEET 5 AA7 5 LYS L 51 LEU L 52 -1 O LYS L 51 N GLN L 43 SHEET 1 AA8 3 VAL L 19 ARG L 24 0 SHEET 2 AA8 3 ASP L 86 ILE L 91 -1 O ILE L 91 N VAL L 19 SHEET 3 AA8 3 SER L 79 SER L 83 -1 N SER L 79 O THR L 88 SHEET 1 AA9 2 ILE L 54 TYR L 55 0 SHEET 2 AA9 2 SER L 66 LEU L 67 -1 O SER L 66 N TYR L 55 SHEET 1 AB1 4 SER L 134 PHE L 136 0 SHEET 2 AB1 4 SER L 151 ASN L 157 -1 O LEU L 155 N PHE L 136 SHEET 3 AB1 4 SER L 194 THR L 200 -1 O LEU L 195 N LEU L 156 SHEET 4 AB1 4 GLU L 181 VAL L 183 -1 N SER L 182 O SER L 196 SHEET 1 AB2 2 LYS L 165 GLN L 167 0 SHEET 2 AB2 2 GLU L 215 THR L 217 -1 O GLU L 215 N GLN L 167 SHEET 1 AB3 5 ASN A 354 ILE A 358 0 SHEET 2 AB3 5 ASN A 394 ARG A 403 -1 O VAL A 395 N ILE A 358 SHEET 3 AB3 5 PRO A 507 GLU A 516 -1 O TYR A 508 N ILE A 402 SHEET 4 AB3 5 GLY A 431 ASN A 437 -1 N CYS A 432 O LEU A 513 SHEET 5 AB3 5 ALA A 376 CYS A 379 -1 N ALA A 376 O ALA A 435 SHEET 1 AB4 2 LEU A 452 TYR A 453 0 SHEET 2 AB4 2 GLN A 493 SER A 494 -1 O GLN A 493 N TYR A 453 SSBOND 1 CYS H 23 CYS H 104 1555 1555 2.03 SSBOND 2 CYS H 155 CYS H 211 1555 1555 2.03 SSBOND 3 CYS L 23 CYS L 104 1555 1555 2.03 SSBOND 4 CYS L 154 CYS L 214 1555 1555 2.04 SSBOND 5 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 6 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 7 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 8 CYS A 480 CYS A 488 1555 1555 2.04 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000