HEADER VIRAL PROTEIN/IMMUNE SYSTEM 11-DEC-24 9KZZ TITLE STRUCTURE OF SARS-COV-2 EG.5.1 VARIANT SPIKE PROTEIN COMPLEXED WITH TITLE 2 ANTIBODY XGI-171 COMPND MOL_ID: 1; COMPND 2 MOLECULE: XGI-171 HEAVY CHAIN; COMPND 3 CHAIN: H, I, J; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: XGI-171 LIGHT CHAIN; COMPND 7 CHAIN: L, M, N; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 11 CHAIN: C, B, A; COMPND 12 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 13 2; SOURCE 14 ORGANISM_TAXID: 2697049; SOURCE 15 STRAIN: OMICRON/EG.5.1; SOURCE 16 GENE: S, 2; SOURCE 17 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 18 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM_CELL_LINE: HEK293F KEYWDS SPIKE-ANTIBODY COMPLEX, VIRAL PROTEIN/IMMUNE SYSTEM, VIRAL PROTEIN- KEYWDS 2 IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR Y.N.QIU,L.SUN REVDAT 1 10-DEC-25 9KZZ 0 JRNL AUTH M.XIE,Y.QIU,X.ZHAO,J.SHI,Y.LIU,Q.ZHANG,J.HE,J.LI,L.LIU, JRNL AUTH 2 S.SUN,Y.ZHU,Q.MAO,Y.LONG,T.Y.OLIVEIRA,Z.WANG,Y.ZHOU,Y.YAN, JRNL AUTH 3 A.XIA,W.ZAI,C.T.MAYER,Y.XIE,S.JIANG,L.LU,R.XIA,F.WU,L.SUN, JRNL AUTH 4 P.WANG,H.CHU,Q.WANG JRNL TITL ORPHAN BROADLY RBD-BINDING ANTIBODIES ANNOTATE THREE JRNL TITL 2 REMAINING CONSERVED RBD EPITOPES ALONG SARS-COV-2 EVOLUTION. JRNL REF NAT COMMUN V. 16 10566 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 41298374 JRNL DOI 10.1038/S41467-025-65596-0 REMARK 2 REMARK 2 RESOLUTION. 3.18 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.180 REMARK 3 NUMBER OF PARTICLES : 30115 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9KZZ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 13-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1300054606. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : EG.5.1 SPIKE PROTEIN (S) IN REMARK 245 COMPLEX WITH ANTIBODY XGI-171; REMARK 245 XGI-171 HEAVY CHAIN; XGI-171 REMARK 245 LIGHT CHAIN; EG.5.1 SPIKE REMARK 245 GLYCOPROTEIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, C, B, A, I, M, J, N, D, REMARK 350 AND CHAINS: E, F, G, K, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 PRO H 129 REMARK 465 LEU H 130 REMARK 465 ALA H 131 REMARK 465 PRO H 132 REMARK 465 SER H 133 REMARK 465 SER H 134 REMARK 465 LYS H 135 REMARK 465 SER H 136 REMARK 465 THR H 137 REMARK 465 SER H 138 REMARK 465 GLY H 139 REMARK 465 GLY H 140 REMARK 465 SER H 194 REMARK 465 LEU H 195 REMARK 465 GLY H 196 REMARK 465 THR H 197 REMARK 465 GLN H 198 REMARK 465 LYS H 220 REMARK 465 SER H 221 REMARK 465 CYS H 222 REMARK 465 ASP H 223 REMARK 465 LYS H 224 REMARK 465 THR H 225 REMARK 465 HIS H 226 REMARK 465 THR H 227 REMARK 465 CYS H 228 REMARK 465 PRO H 229 REMARK 465 PRO H 230 REMARK 465 CYS H 231 REMARK 465 PRO H 232 REMARK 465 ALA H 233 REMARK 465 PRO H 234 REMARK 465 GLU H 235 REMARK 465 LEU H 236 REMARK 465 LEU H 237 REMARK 465 GLY H 238 REMARK 465 GLY H 239 REMARK 465 PRO H 240 REMARK 465 SER H 241 REMARK 465 VAL H 242 REMARK 465 PHE H 243 REMARK 465 LEU H 244 REMARK 465 PHE H 245 REMARK 465 PRO H 246 REMARK 465 PRO H 247 REMARK 465 LYS H 248 REMARK 465 PRO H 249 REMARK 465 LYS H 250 REMARK 465 ASP H 251 REMARK 465 THR H 252 REMARK 465 LEU H 253 REMARK 465 MET H 254 REMARK 465 ILE H 255 REMARK 465 SER H 256 REMARK 465 ARG H 257 REMARK 465 THR H 258 REMARK 465 PRO H 259 REMARK 465 GLU H 260 REMARK 465 VAL H 261 REMARK 465 THR H 262 REMARK 465 CYS H 263 REMARK 465 VAL H 264 REMARK 465 VAL H 265 REMARK 465 VAL H 266 REMARK 465 ASP H 267 REMARK 465 VAL H 268 REMARK 465 SER H 269 REMARK 465 HIS H 270 REMARK 465 GLU H 271 REMARK 465 ASP H 272 REMARK 465 PRO H 273 REMARK 465 GLU H 274 REMARK 465 VAL H 275 REMARK 465 LYS H 276 REMARK 465 PHE H 277 REMARK 465 ASN H 278 REMARK 465 TRP H 279 REMARK 465 TYR H 280 REMARK 465 VAL H 281 REMARK 465 ASP H 282 REMARK 465 GLY H 283 REMARK 465 VAL H 284 REMARK 465 GLU H 285 REMARK 465 VAL H 286 REMARK 465 HIS H 287 REMARK 465 ASN H 288 REMARK 465 ALA H 289 REMARK 465 LYS H 290 REMARK 465 THR H 291 REMARK 465 LYS H 292 REMARK 465 PRO H 293 REMARK 465 ARG H 294 REMARK 465 GLU H 295 REMARK 465 GLU H 296 REMARK 465 GLN H 297 REMARK 465 TYR H 298 REMARK 465 ASN H 299 REMARK 465 SER H 300 REMARK 465 THR H 301 REMARK 465 TYR H 302 REMARK 465 ARG H 303 REMARK 465 VAL H 304 REMARK 465 VAL H 305 REMARK 465 SER H 306 REMARK 465 VAL H 307 REMARK 465 LEU H 308 REMARK 465 THR H 309 REMARK 465 VAL H 310 REMARK 465 LEU H 311 REMARK 465 HIS H 312 REMARK 465 GLN H 313 REMARK 465 ASP H 314 REMARK 465 TRP H 315 REMARK 465 LEU H 316 REMARK 465 ASN H 317 REMARK 465 GLY H 318 REMARK 465 LYS H 319 REMARK 465 GLU H 320 REMARK 465 TYR H 321 REMARK 465 LYS H 322 REMARK 465 CYS H 323 REMARK 465 LYS H 324 REMARK 465 VAL H 325 REMARK 465 SER H 326 REMARK 465 ASN H 327 REMARK 465 LYS H 328 REMARK 465 ALA H 329 REMARK 465 LEU H 330 REMARK 465 PRO H 331 REMARK 465 ALA H 332 REMARK 465 PRO H 333 REMARK 465 ILE H 334 REMARK 465 GLU H 335 REMARK 465 LYS H 336 REMARK 465 THR H 337 REMARK 465 ILE H 338 REMARK 465 SER H 339 REMARK 465 LYS H 340 REMARK 465 ALA H 341 REMARK 465 LYS H 342 REMARK 465 GLY H 343 REMARK 465 GLN H 344 REMARK 465 PRO H 345 REMARK 465 ARG H 346 REMARK 465 GLU H 347 REMARK 465 PRO H 348 REMARK 465 GLN H 349 REMARK 465 VAL H 350 REMARK 465 TYR H 351 REMARK 465 THR H 352 REMARK 465 LEU H 353 REMARK 465 PRO H 354 REMARK 465 PRO H 355 REMARK 465 SER H 356 REMARK 465 ARG H 357 REMARK 465 GLU H 358 REMARK 465 GLU H 359 REMARK 465 MET H 360 REMARK 465 THR H 361 REMARK 465 LYS H 362 REMARK 465 ASN H 363 REMARK 465 GLN H 364 REMARK 465 VAL H 365 REMARK 465 SER H 366 REMARK 465 LEU H 367 REMARK 465 THR H 368 REMARK 465 CYS H 369 REMARK 465 LEU H 370 REMARK 465 VAL H 371 REMARK 465 LYS H 372 REMARK 465 GLY H 373 REMARK 465 PHE H 374 REMARK 465 TYR H 375 REMARK 465 PRO H 376 REMARK 465 SER H 377 REMARK 465 ASP H 378 REMARK 465 ILE H 379 REMARK 465 ALA H 380 REMARK 465 VAL H 381 REMARK 465 GLU H 382 REMARK 465 TRP H 383 REMARK 465 GLU H 384 REMARK 465 SER H 385 REMARK 465 ASN H 386 REMARK 465 GLY H 387 REMARK 465 GLN H 388 REMARK 465 PRO H 389 REMARK 465 GLU H 390 REMARK 465 ASN H 391 REMARK 465 ASN H 392 REMARK 465 TYR H 393 REMARK 465 LYS H 394 REMARK 465 THR H 395 REMARK 465 THR H 396 REMARK 465 PRO H 397 REMARK 465 PRO H 398 REMARK 465 VAL H 399 REMARK 465 LEU H 400 REMARK 465 ASP H 401 REMARK 465 SER H 402 REMARK 465 ASP H 403 REMARK 465 GLY H 404 REMARK 465 SER H 405 REMARK 465 PHE H 406 REMARK 465 PHE H 407 REMARK 465 LEU H 408 REMARK 465 TYR H 409 REMARK 465 SER H 410 REMARK 465 LYS H 411 REMARK 465 LEU H 412 REMARK 465 THR H 413 REMARK 465 VAL H 414 REMARK 465 ASP H 415 REMARK 465 LYS H 416 REMARK 465 SER H 417 REMARK 465 ARG H 418 REMARK 465 TRP H 419 REMARK 465 GLN H 420 REMARK 465 GLN H 421 REMARK 465 GLY H 422 REMARK 465 ASN H 423 REMARK 465 VAL H 424 REMARK 465 PHE H 425 REMARK 465 SER H 426 REMARK 465 CYS H 427 REMARK 465 SER H 428 REMARK 465 VAL H 429 REMARK 465 MET H 430 REMARK 465 HIS H 431 REMARK 465 GLU H 432 REMARK 465 ALA H 433 REMARK 465 LEU H 434 REMARK 465 HIS H 435 REMARK 465 ASN H 436 REMARK 465 HIS H 437 REMARK 465 TYR H 438 REMARK 465 THR H 439 REMARK 465 GLN H 440 REMARK 465 LYS H 441 REMARK 465 SER H 442 REMARK 465 LEU H 443 REMARK 465 SER H 444 REMARK 465 LEU H 445 REMARK 465 SER H 446 REMARK 465 PRO H 447 REMARK 465 GLY H 448 REMARK 465 LYS H 449 REMARK 465 ALA L 154 REMARK 465 LEU L 155 REMARK 465 GLN L 156 REMARK 465 SER L 157 REMARK 465 GLU L 214 REMARK 465 CYS L 215 REMARK 465 MET C -10 REMARK 465 PRO C -9 REMARK 465 MET C -8 REMARK 465 GLY C -7 REMARK 465 SER C -6 REMARK 465 LEU C -5 REMARK 465 GLN C -4 REMARK 465 PRO C -3 REMARK 465 LEU C -2 REMARK 465 ALA C -1 REMARK 465 THR C 0 REMARK 465 LEU C 1 REMARK 465 TYR C 2 REMARK 465 LEU C 3 REMARK 465 LEU C 4 REMARK 465 GLY C 5 REMARK 465 MET C 6 REMARK 465 LEU C 7 REMARK 465 VAL C 8 REMARK 465 ALA C 9 REMARK 465 SER C 10 REMARK 465 VAL C 11 REMARK 465 LEU C 12 REMARK 465 ALA C 13 REMARK 465 HIS C 69 REMARK 465 VAL C 70 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 76 REMARK 465 LYS C 77 REMARK 465 ARG C 78 REMARK 465 PHE C 79 REMARK 465 ASP C 80 REMARK 465 ASN C 81 REMARK 465 GLN C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 MET C 153 REMARK 465 PHE C 175 REMARK 465 LEU C 176 REMARK 465 MET C 177 REMARK 465 ASP C 178 REMARK 465 LEU C 179 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLU C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 PHE C 186 REMARK 465 LYS C 187 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 VAL C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 PRO C 621 REMARK 465 VAL C 622 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 THR C 638 REMARK 465 GLY C 639 REMARK 465 SER C 640 REMARK 465 GLN C 677 REMARK 465 THR C 678 REMARK 465 LYS C 679 REMARK 465 SER C 680 REMARK 465 HIS C 681 REMARK 465 GLY C 682 REMARK 465 SER C 683 REMARK 465 ALA C 684 REMARK 465 SER C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 SER C 689 REMARK 465 THR C 827 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 CYS C 851 REMARK 465 ALA C 852 REMARK 465 GLN C 853 REMARK 465 LEU C 1145 REMARK 465 ASP C 1146 REMARK 465 SER C 1147 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 GLY C 1209 REMARK 465 SER C 1210 REMARK 465 GLY C 1211 REMARK 465 TYR C 1212 REMARK 465 ILE C 1213 REMARK 465 PRO C 1214 REMARK 465 GLU C 1215 REMARK 465 ALA C 1216 REMARK 465 PRO C 1217 REMARK 465 ARG C 1218 REMARK 465 ASP C 1219 REMARK 465 GLY C 1220 REMARK 465 GLN C 1221 REMARK 465 ALA C 1222 REMARK 465 TYR C 1223 REMARK 465 VAL C 1224 REMARK 465 ARG C 1225 REMARK 465 LYS C 1226 REMARK 465 ASP C 1227 REMARK 465 GLY C 1228 REMARK 465 GLU C 1229 REMARK 465 TRP C 1230 REMARK 465 VAL C 1231 REMARK 465 PHE C 1232 REMARK 465 LEU C 1233 REMARK 465 SER C 1234 REMARK 465 THR C 1235 REMARK 465 PHE C 1236 REMARK 465 LEU C 1237 REMARK 465 SER C 1238 REMARK 465 GLY C 1239 REMARK 465 LEU C 1240 REMARK 465 GLU C 1241 REMARK 465 VAL C 1242 REMARK 465 LEU C 1243 REMARK 465 PHE C 1244 REMARK 465 GLN C 1245 REMARK 465 GLY C 1246 REMARK 465 PRO C 1247 REMARK 465 GLY C 1248 REMARK 465 GLY C 1249 REMARK 465 TRP C 1250 REMARK 465 SER C 1251 REMARK 465 HIS C 1252 REMARK 465 PRO C 1253 REMARK 465 GLN C 1254 REMARK 465 PHE C 1255 REMARK 465 GLU C 1256 REMARK 465 LYS C 1257 REMARK 465 GLY C 1258 REMARK 465 GLY C 1259 REMARK 465 GLY C 1260 REMARK 465 SER C 1261 REMARK 465 GLY C 1262 REMARK 465 GLY C 1263 REMARK 465 GLY C 1264 REMARK 465 SER C 1265 REMARK 465 GLY C 1266 REMARK 465 GLY C 1267 REMARK 465 SER C 1268 REMARK 465 ALA C 1269 REMARK 465 TRP C 1270 REMARK 465 SER C 1271 REMARK 465 HIS C 1272 REMARK 465 PRO C 1273 REMARK 465 GLN C 1274 REMARK 465 PHE C 1275 REMARK 465 GLU C 1276 REMARK 465 LYS C 1277 REMARK 465 GLY C 1278 REMARK 465 GLY C 1279 REMARK 465 SER C 1280 REMARK 465 HIS C 1281 REMARK 465 HIS C 1282 REMARK 465 HIS C 1283 REMARK 465 HIS C 1284 REMARK 465 HIS C 1285 REMARK 465 HIS C 1286 REMARK 465 HIS C 1287 REMARK 465 HIS C 1288 REMARK 465 MET B -10 REMARK 465 PRO B -9 REMARK 465 MET B -8 REMARK 465 GLY B -7 REMARK 465 SER B -6 REMARK 465 LEU B -5 REMARK 465 GLN B -4 REMARK 465 PRO B -3 REMARK 465 LEU B -2 REMARK 465 ALA B -1 REMARK 465 THR B 0 REMARK 465 LEU B 1 REMARK 465 TYR B 2 REMARK 465 LEU B 3 REMARK 465 LEU B 4 REMARK 465 GLY B 5 REMARK 465 MET B 6 REMARK 465 LEU B 7 REMARK 465 VAL B 8 REMARK 465 ALA B 9 REMARK 465 SER B 10 REMARK 465 VAL B 11 REMARK 465 LEU B 12 REMARK 465 ALA B 13 REMARK 465 ALA B 67 REMARK 465 ILE B 68 REMARK 465 HIS B 69 REMARK 465 VAL B 70 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 THR B 76 REMARK 465 LYS B 77 REMARK 465 ARG B 78 REMARK 465 PHE B 79 REMARK 465 ASP B 80 REMARK 465 ASN B 81 REMARK 465 GLN B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASN B 149 REMARK 465 LYS B 150 REMARK 465 SER B 151 REMARK 465 TRP B 152 REMARK 465 MET B 153 REMARK 465 PHE B 175 REMARK 465 LEU B 176 REMARK 465 MET B 177 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLU B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 PHE B 186 REMARK 465 LYS B 187 REMARK 465 ARG B 246 REMARK 465 SER B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 VAL B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 SER B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 TRP B 258 REMARK 465 THR B 259 REMARK 465 ALA B 260 REMARK 465 GLY B 261 REMARK 465 VAL B 622 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 TYR B 636 REMARK 465 SER B 637 REMARK 465 THR B 638 REMARK 465 GLY B 639 REMARK 465 GLN B 677 REMARK 465 THR B 678 REMARK 465 LYS B 679 REMARK 465 SER B 680 REMARK 465 HIS B 681 REMARK 465 GLY B 682 REMARK 465 SER B 683 REMARK 465 ALA B 684 REMARK 465 SER B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 SER B 689 REMARK 465 THR B 827 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 CYS B 851 REMARK 465 ALA B 852 REMARK 465 GLN B 853 REMARK 465 LYS B 854 REMARK 465 LEU B 1145 REMARK 465 ASP B 1146 REMARK 465 SER B 1147 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 GLY B 1209 REMARK 465 SER B 1210 REMARK 465 GLY B 1211 REMARK 465 TYR B 1212 REMARK 465 ILE B 1213 REMARK 465 PRO B 1214 REMARK 465 GLU B 1215 REMARK 465 ALA B 1216 REMARK 465 PRO B 1217 REMARK 465 ARG B 1218 REMARK 465 ASP B 1219 REMARK 465 GLY B 1220 REMARK 465 GLN B 1221 REMARK 465 ALA B 1222 REMARK 465 TYR B 1223 REMARK 465 VAL B 1224 REMARK 465 ARG B 1225 REMARK 465 LYS B 1226 REMARK 465 ASP B 1227 REMARK 465 GLY B 1228 REMARK 465 GLU B 1229 REMARK 465 TRP B 1230 REMARK 465 VAL B 1231 REMARK 465 PHE B 1232 REMARK 465 LEU B 1233 REMARK 465 SER B 1234 REMARK 465 THR B 1235 REMARK 465 PHE B 1236 REMARK 465 LEU B 1237 REMARK 465 SER B 1238 REMARK 465 GLY B 1239 REMARK 465 LEU B 1240 REMARK 465 GLU B 1241 REMARK 465 VAL B 1242 REMARK 465 LEU B 1243 REMARK 465 PHE B 1244 REMARK 465 GLN B 1245 REMARK 465 GLY B 1246 REMARK 465 PRO B 1247 REMARK 465 GLY B 1248 REMARK 465 GLY B 1249 REMARK 465 TRP B 1250 REMARK 465 SER B 1251 REMARK 465 HIS B 1252 REMARK 465 PRO B 1253 REMARK 465 GLN B 1254 REMARK 465 PHE B 1255 REMARK 465 GLU B 1256 REMARK 465 LYS B 1257 REMARK 465 GLY B 1258 REMARK 465 GLY B 1259 REMARK 465 GLY B 1260 REMARK 465 SER B 1261 REMARK 465 GLY B 1262 REMARK 465 GLY B 1263 REMARK 465 GLY B 1264 REMARK 465 SER B 1265 REMARK 465 GLY B 1266 REMARK 465 GLY B 1267 REMARK 465 SER B 1268 REMARK 465 ALA B 1269 REMARK 465 TRP B 1270 REMARK 465 SER B 1271 REMARK 465 HIS B 1272 REMARK 465 PRO B 1273 REMARK 465 GLN B 1274 REMARK 465 PHE B 1275 REMARK 465 GLU B 1276 REMARK 465 LYS B 1277 REMARK 465 GLY B 1278 REMARK 465 GLY B 1279 REMARK 465 SER B 1280 REMARK 465 HIS B 1281 REMARK 465 HIS B 1282 REMARK 465 HIS B 1283 REMARK 465 HIS B 1284 REMARK 465 HIS B 1285 REMARK 465 HIS B 1286 REMARK 465 HIS B 1287 REMARK 465 HIS B 1288 REMARK 465 MET A -10 REMARK 465 PRO A -9 REMARK 465 MET A -8 REMARK 465 GLY A -7 REMARK 465 SER A -6 REMARK 465 LEU A -5 REMARK 465 GLN A -4 REMARK 465 PRO A -3 REMARK 465 LEU A -2 REMARK 465 ALA A -1 REMARK 465 THR A 0 REMARK 465 LEU A 1 REMARK 465 TYR A 2 REMARK 465 LEU A 3 REMARK 465 LEU A 4 REMARK 465 GLY A 5 REMARK 465 MET A 6 REMARK 465 LEU A 7 REMARK 465 VAL A 8 REMARK 465 ALA A 9 REMARK 465 SER A 10 REMARK 465 VAL A 11 REMARK 465 LEU A 12 REMARK 465 ALA A 13 REMARK 465 GLN A 14 REMARK 465 ALA A 67 REMARK 465 ILE A 68 REMARK 465 HIS A 69 REMARK 465 VAL A 70 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 76 REMARK 465 GLN A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 PHE A 175 REMARK 465 LEU A 176 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLU A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 PHE A 186 REMARK 465 LYS A 187 REMARK 465 ASN A 211 REMARK 465 LEU A 212 REMARK 465 GLU A 213 REMARK 465 ARG A 214 REMARK 465 ASP A 215 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 VAL A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 SER A 640 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 LYS A 679 REMARK 465 SER A 680 REMARK 465 HIS A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 SER A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 SER A 689 REMARK 465 THR A 827 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 LEU A 1145 REMARK 465 ASP A 1146 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 GLY A 1209 REMARK 465 SER A 1210 REMARK 465 GLY A 1211 REMARK 465 TYR A 1212 REMARK 465 ILE A 1213 REMARK 465 PRO A 1214 REMARK 465 GLU A 1215 REMARK 465 ALA A 1216 REMARK 465 PRO A 1217 REMARK 465 ARG A 1218 REMARK 465 ASP A 1219 REMARK 465 GLY A 1220 REMARK 465 GLN A 1221 REMARK 465 ALA A 1222 REMARK 465 TYR A 1223 REMARK 465 VAL A 1224 REMARK 465 ARG A 1225 REMARK 465 LYS A 1226 REMARK 465 ASP A 1227 REMARK 465 GLY A 1228 REMARK 465 GLU A 1229 REMARK 465 TRP A 1230 REMARK 465 VAL A 1231 REMARK 465 PHE A 1232 REMARK 465 LEU A 1233 REMARK 465 SER A 1234 REMARK 465 THR A 1235 REMARK 465 PHE A 1236 REMARK 465 LEU A 1237 REMARK 465 SER A 1238 REMARK 465 GLY A 1239 REMARK 465 LEU A 1240 REMARK 465 GLU A 1241 REMARK 465 VAL A 1242 REMARK 465 LEU A 1243 REMARK 465 PHE A 1244 REMARK 465 GLN A 1245 REMARK 465 GLY A 1246 REMARK 465 PRO A 1247 REMARK 465 GLY A 1248 REMARK 465 GLY A 1249 REMARK 465 TRP A 1250 REMARK 465 SER A 1251 REMARK 465 HIS A 1252 REMARK 465 PRO A 1253 REMARK 465 GLN A 1254 REMARK 465 PHE A 1255 REMARK 465 GLU A 1256 REMARK 465 LYS A 1257 REMARK 465 GLY A 1258 REMARK 465 GLY A 1259 REMARK 465 GLY A 1260 REMARK 465 SER A 1261 REMARK 465 GLY A 1262 REMARK 465 GLY A 1263 REMARK 465 GLY A 1264 REMARK 465 SER A 1265 REMARK 465 GLY A 1266 REMARK 465 GLY A 1267 REMARK 465 SER A 1268 REMARK 465 ALA A 1269 REMARK 465 TRP A 1270 REMARK 465 SER A 1271 REMARK 465 HIS A 1272 REMARK 465 PRO A 1273 REMARK 465 GLN A 1274 REMARK 465 PHE A 1275 REMARK 465 GLU A 1276 REMARK 465 LYS A 1277 REMARK 465 GLY A 1278 REMARK 465 GLY A 1279 REMARK 465 SER A 1280 REMARK 465 HIS A 1281 REMARK 465 HIS A 1282 REMARK 465 HIS A 1283 REMARK 465 HIS A 1284 REMARK 465 HIS A 1285 REMARK 465 HIS A 1286 REMARK 465 HIS A 1287 REMARK 465 HIS A 1288 REMARK 465 PRO I 129 REMARK 465 LEU I 130 REMARK 465 ALA I 131 REMARK 465 PRO I 132 REMARK 465 SER I 133 REMARK 465 SER I 134 REMARK 465 LYS I 135 REMARK 465 SER I 136 REMARK 465 THR I 137 REMARK 465 SER I 138 REMARK 465 GLY I 139 REMARK 465 GLY I 140 REMARK 465 SER I 194 REMARK 465 LEU I 195 REMARK 465 GLY I 196 REMARK 465 THR I 197 REMARK 465 GLN I 198 REMARK 465 LYS I 220 REMARK 465 SER I 221 REMARK 465 CYS I 222 REMARK 465 ASP I 223 REMARK 465 LYS I 224 REMARK 465 THR I 225 REMARK 465 HIS I 226 REMARK 465 THR I 227 REMARK 465 CYS I 228 REMARK 465 PRO I 229 REMARK 465 PRO I 230 REMARK 465 CYS I 231 REMARK 465 PRO I 232 REMARK 465 ALA I 233 REMARK 465 PRO I 234 REMARK 465 GLU I 235 REMARK 465 LEU I 236 REMARK 465 LEU I 237 REMARK 465 GLY I 238 REMARK 465 GLY I 239 REMARK 465 PRO I 240 REMARK 465 SER I 241 REMARK 465 VAL I 242 REMARK 465 PHE I 243 REMARK 465 LEU I 244 REMARK 465 PHE I 245 REMARK 465 PRO I 246 REMARK 465 PRO I 247 REMARK 465 LYS I 248 REMARK 465 PRO I 249 REMARK 465 LYS I 250 REMARK 465 ASP I 251 REMARK 465 THR I 252 REMARK 465 LEU I 253 REMARK 465 MET I 254 REMARK 465 ILE I 255 REMARK 465 SER I 256 REMARK 465 ARG I 257 REMARK 465 THR I 258 REMARK 465 PRO I 259 REMARK 465 GLU I 260 REMARK 465 VAL I 261 REMARK 465 THR I 262 REMARK 465 CYS I 263 REMARK 465 VAL I 264 REMARK 465 VAL I 265 REMARK 465 VAL I 266 REMARK 465 ASP I 267 REMARK 465 VAL I 268 REMARK 465 SER I 269 REMARK 465 HIS I 270 REMARK 465 GLU I 271 REMARK 465 ASP I 272 REMARK 465 PRO I 273 REMARK 465 GLU I 274 REMARK 465 VAL I 275 REMARK 465 LYS I 276 REMARK 465 PHE I 277 REMARK 465 ASN I 278 REMARK 465 TRP I 279 REMARK 465 TYR I 280 REMARK 465 VAL I 281 REMARK 465 ASP I 282 REMARK 465 GLY I 283 REMARK 465 VAL I 284 REMARK 465 GLU I 285 REMARK 465 VAL I 286 REMARK 465 HIS I 287 REMARK 465 ASN I 288 REMARK 465 ALA I 289 REMARK 465 LYS I 290 REMARK 465 THR I 291 REMARK 465 LYS I 292 REMARK 465 PRO I 293 REMARK 465 ARG I 294 REMARK 465 GLU I 295 REMARK 465 GLU I 296 REMARK 465 GLN I 297 REMARK 465 TYR I 298 REMARK 465 ASN I 299 REMARK 465 SER I 300 REMARK 465 THR I 301 REMARK 465 TYR I 302 REMARK 465 ARG I 303 REMARK 465 VAL I 304 REMARK 465 VAL I 305 REMARK 465 SER I 306 REMARK 465 VAL I 307 REMARK 465 LEU I 308 REMARK 465 THR I 309 REMARK 465 VAL I 310 REMARK 465 LEU I 311 REMARK 465 HIS I 312 REMARK 465 GLN I 313 REMARK 465 ASP I 314 REMARK 465 TRP I 315 REMARK 465 LEU I 316 REMARK 465 ASN I 317 REMARK 465 GLY I 318 REMARK 465 LYS I 319 REMARK 465 GLU I 320 REMARK 465 TYR I 321 REMARK 465 LYS I 322 REMARK 465 CYS I 323 REMARK 465 LYS I 324 REMARK 465 VAL I 325 REMARK 465 SER I 326 REMARK 465 ASN I 327 REMARK 465 LYS I 328 REMARK 465 ALA I 329 REMARK 465 LEU I 330 REMARK 465 PRO I 331 REMARK 465 ALA I 332 REMARK 465 PRO I 333 REMARK 465 ILE I 334 REMARK 465 GLU I 335 REMARK 465 LYS I 336 REMARK 465 THR I 337 REMARK 465 ILE I 338 REMARK 465 SER I 339 REMARK 465 LYS I 340 REMARK 465 ALA I 341 REMARK 465 LYS I 342 REMARK 465 GLY I 343 REMARK 465 GLN I 344 REMARK 465 PRO I 345 REMARK 465 ARG I 346 REMARK 465 GLU I 347 REMARK 465 PRO I 348 REMARK 465 GLN I 349 REMARK 465 VAL I 350 REMARK 465 TYR I 351 REMARK 465 THR I 352 REMARK 465 LEU I 353 REMARK 465 PRO I 354 REMARK 465 PRO I 355 REMARK 465 SER I 356 REMARK 465 ARG I 357 REMARK 465 GLU I 358 REMARK 465 GLU I 359 REMARK 465 MET I 360 REMARK 465 THR I 361 REMARK 465 LYS I 362 REMARK 465 ASN I 363 REMARK 465 GLN I 364 REMARK 465 VAL I 365 REMARK 465 SER I 366 REMARK 465 LEU I 367 REMARK 465 THR I 368 REMARK 465 CYS I 369 REMARK 465 LEU I 370 REMARK 465 VAL I 371 REMARK 465 LYS I 372 REMARK 465 GLY I 373 REMARK 465 PHE I 374 REMARK 465 TYR I 375 REMARK 465 PRO I 376 REMARK 465 SER I 377 REMARK 465 ASP I 378 REMARK 465 ILE I 379 REMARK 465 ALA I 380 REMARK 465 VAL I 381 REMARK 465 GLU I 382 REMARK 465 TRP I 383 REMARK 465 GLU I 384 REMARK 465 SER I 385 REMARK 465 ASN I 386 REMARK 465 GLY I 387 REMARK 465 GLN I 388 REMARK 465 PRO I 389 REMARK 465 GLU I 390 REMARK 465 ASN I 391 REMARK 465 ASN I 392 REMARK 465 TYR I 393 REMARK 465 LYS I 394 REMARK 465 THR I 395 REMARK 465 THR I 396 REMARK 465 PRO I 397 REMARK 465 PRO I 398 REMARK 465 VAL I 399 REMARK 465 LEU I 400 REMARK 465 ASP I 401 REMARK 465 SER I 402 REMARK 465 ASP I 403 REMARK 465 GLY I 404 REMARK 465 SER I 405 REMARK 465 PHE I 406 REMARK 465 PHE I 407 REMARK 465 LEU I 408 REMARK 465 TYR I 409 REMARK 465 SER I 410 REMARK 465 LYS I 411 REMARK 465 LEU I 412 REMARK 465 THR I 413 REMARK 465 VAL I 414 REMARK 465 ASP I 415 REMARK 465 LYS I 416 REMARK 465 SER I 417 REMARK 465 ARG I 418 REMARK 465 TRP I 419 REMARK 465 GLN I 420 REMARK 465 GLN I 421 REMARK 465 GLY I 422 REMARK 465 ASN I 423 REMARK 465 VAL I 424 REMARK 465 PHE I 425 REMARK 465 SER I 426 REMARK 465 CYS I 427 REMARK 465 SER I 428 REMARK 465 VAL I 429 REMARK 465 MET I 430 REMARK 465 HIS I 431 REMARK 465 GLU I 432 REMARK 465 ALA I 433 REMARK 465 LEU I 434 REMARK 465 HIS I 435 REMARK 465 ASN I 436 REMARK 465 HIS I 437 REMARK 465 TYR I 438 REMARK 465 THR I 439 REMARK 465 GLN I 440 REMARK 465 LYS I 441 REMARK 465 SER I 442 REMARK 465 LEU I 443 REMARK 465 SER I 444 REMARK 465 LEU I 445 REMARK 465 SER I 446 REMARK 465 PRO I 447 REMARK 465 GLY I 448 REMARK 465 LYS I 449 REMARK 465 ALA M 154 REMARK 465 LEU M 155 REMARK 465 GLN M 156 REMARK 465 SER M 157 REMARK 465 GLU M 214 REMARK 465 CYS M 215 REMARK 465 PRO J 129 REMARK 465 LEU J 130 REMARK 465 ALA J 131 REMARK 465 PRO J 132 REMARK 465 SER J 133 REMARK 465 SER J 134 REMARK 465 LYS J 135 REMARK 465 SER J 136 REMARK 465 THR J 137 REMARK 465 SER J 138 REMARK 465 GLY J 139 REMARK 465 GLY J 140 REMARK 465 SER J 194 REMARK 465 LEU J 195 REMARK 465 GLY J 196 REMARK 465 THR J 197 REMARK 465 GLN J 198 REMARK 465 LYS J 220 REMARK 465 SER J 221 REMARK 465 CYS J 222 REMARK 465 ASP J 223 REMARK 465 LYS J 224 REMARK 465 THR J 225 REMARK 465 HIS J 226 REMARK 465 THR J 227 REMARK 465 CYS J 228 REMARK 465 PRO J 229 REMARK 465 PRO J 230 REMARK 465 CYS J 231 REMARK 465 PRO J 232 REMARK 465 ALA J 233 REMARK 465 PRO J 234 REMARK 465 GLU J 235 REMARK 465 LEU J 236 REMARK 465 LEU J 237 REMARK 465 GLY J 238 REMARK 465 GLY J 239 REMARK 465 PRO J 240 REMARK 465 SER J 241 REMARK 465 VAL J 242 REMARK 465 PHE J 243 REMARK 465 LEU J 244 REMARK 465 PHE J 245 REMARK 465 PRO J 246 REMARK 465 PRO J 247 REMARK 465 LYS J 248 REMARK 465 PRO J 249 REMARK 465 LYS J 250 REMARK 465 ASP J 251 REMARK 465 THR J 252 REMARK 465 LEU J 253 REMARK 465 MET J 254 REMARK 465 ILE J 255 REMARK 465 SER J 256 REMARK 465 ARG J 257 REMARK 465 THR J 258 REMARK 465 PRO J 259 REMARK 465 GLU J 260 REMARK 465 VAL J 261 REMARK 465 THR J 262 REMARK 465 CYS J 263 REMARK 465 VAL J 264 REMARK 465 VAL J 265 REMARK 465 VAL J 266 REMARK 465 ASP J 267 REMARK 465 VAL J 268 REMARK 465 SER J 269 REMARK 465 HIS J 270 REMARK 465 GLU J 271 REMARK 465 ASP J 272 REMARK 465 PRO J 273 REMARK 465 GLU J 274 REMARK 465 VAL J 275 REMARK 465 LYS J 276 REMARK 465 PHE J 277 REMARK 465 ASN J 278 REMARK 465 TRP J 279 REMARK 465 TYR J 280 REMARK 465 VAL J 281 REMARK 465 ASP J 282 REMARK 465 GLY J 283 REMARK 465 VAL J 284 REMARK 465 GLU J 285 REMARK 465 VAL J 286 REMARK 465 HIS J 287 REMARK 465 ASN J 288 REMARK 465 ALA J 289 REMARK 465 LYS J 290 REMARK 465 THR J 291 REMARK 465 LYS J 292 REMARK 465 PRO J 293 REMARK 465 ARG J 294 REMARK 465 GLU J 295 REMARK 465 GLU J 296 REMARK 465 GLN J 297 REMARK 465 TYR J 298 REMARK 465 ASN J 299 REMARK 465 SER J 300 REMARK 465 THR J 301 REMARK 465 TYR J 302 REMARK 465 ARG J 303 REMARK 465 VAL J 304 REMARK 465 VAL J 305 REMARK 465 SER J 306 REMARK 465 VAL J 307 REMARK 465 LEU J 308 REMARK 465 THR J 309 REMARK 465 VAL J 310 REMARK 465 LEU J 311 REMARK 465 HIS J 312 REMARK 465 GLN J 313 REMARK 465 ASP J 314 REMARK 465 TRP J 315 REMARK 465 LEU J 316 REMARK 465 ASN J 317 REMARK 465 GLY J 318 REMARK 465 LYS J 319 REMARK 465 GLU J 320 REMARK 465 TYR J 321 REMARK 465 LYS J 322 REMARK 465 CYS J 323 REMARK 465 LYS J 324 REMARK 465 VAL J 325 REMARK 465 SER J 326 REMARK 465 ASN J 327 REMARK 465 LYS J 328 REMARK 465 ALA J 329 REMARK 465 LEU J 330 REMARK 465 PRO J 331 REMARK 465 ALA J 332 REMARK 465 PRO J 333 REMARK 465 ILE J 334 REMARK 465 GLU J 335 REMARK 465 LYS J 336 REMARK 465 THR J 337 REMARK 465 ILE J 338 REMARK 465 SER J 339 REMARK 465 LYS J 340 REMARK 465 ALA J 341 REMARK 465 LYS J 342 REMARK 465 GLY J 343 REMARK 465 GLN J 344 REMARK 465 PRO J 345 REMARK 465 ARG J 346 REMARK 465 GLU J 347 REMARK 465 PRO J 348 REMARK 465 GLN J 349 REMARK 465 VAL J 350 REMARK 465 TYR J 351 REMARK 465 THR J 352 REMARK 465 LEU J 353 REMARK 465 PRO J 354 REMARK 465 PRO J 355 REMARK 465 SER J 356 REMARK 465 ARG J 357 REMARK 465 GLU J 358 REMARK 465 GLU J 359 REMARK 465 MET J 360 REMARK 465 THR J 361 REMARK 465 LYS J 362 REMARK 465 ASN J 363 REMARK 465 GLN J 364 REMARK 465 VAL J 365 REMARK 465 SER J 366 REMARK 465 LEU J 367 REMARK 465 THR J 368 REMARK 465 CYS J 369 REMARK 465 LEU J 370 REMARK 465 VAL J 371 REMARK 465 LYS J 372 REMARK 465 GLY J 373 REMARK 465 PHE J 374 REMARK 465 TYR J 375 REMARK 465 PRO J 376 REMARK 465 SER J 377 REMARK 465 ASP J 378 REMARK 465 ILE J 379 REMARK 465 ALA J 380 REMARK 465 VAL J 381 REMARK 465 GLU J 382 REMARK 465 TRP J 383 REMARK 465 GLU J 384 REMARK 465 SER J 385 REMARK 465 ASN J 386 REMARK 465 GLY J 387 REMARK 465 GLN J 388 REMARK 465 PRO J 389 REMARK 465 GLU J 390 REMARK 465 ASN J 391 REMARK 465 ASN J 392 REMARK 465 TYR J 393 REMARK 465 LYS J 394 REMARK 465 THR J 395 REMARK 465 THR J 396 REMARK 465 PRO J 397 REMARK 465 PRO J 398 REMARK 465 VAL J 399 REMARK 465 LEU J 400 REMARK 465 ASP J 401 REMARK 465 SER J 402 REMARK 465 ASP J 403 REMARK 465 GLY J 404 REMARK 465 SER J 405 REMARK 465 PHE J 406 REMARK 465 PHE J 407 REMARK 465 LEU J 408 REMARK 465 TYR J 409 REMARK 465 SER J 410 REMARK 465 LYS J 411 REMARK 465 LEU J 412 REMARK 465 THR J 413 REMARK 465 VAL J 414 REMARK 465 ASP J 415 REMARK 465 LYS J 416 REMARK 465 SER J 417 REMARK 465 ARG J 418 REMARK 465 TRP J 419 REMARK 465 GLN J 420 REMARK 465 GLN J 421 REMARK 465 GLY J 422 REMARK 465 ASN J 423 REMARK 465 VAL J 424 REMARK 465 PHE J 425 REMARK 465 SER J 426 REMARK 465 CYS J 427 REMARK 465 SER J 428 REMARK 465 VAL J 429 REMARK 465 MET J 430 REMARK 465 HIS J 431 REMARK 465 GLU J 432 REMARK 465 ALA J 433 REMARK 465 LEU J 434 REMARK 465 HIS J 435 REMARK 465 ASN J 436 REMARK 465 HIS J 437 REMARK 465 TYR J 438 REMARK 465 THR J 439 REMARK 465 GLN J 440 REMARK 465 LYS J 441 REMARK 465 SER J 442 REMARK 465 LEU J 443 REMARK 465 SER J 444 REMARK 465 LEU J 445 REMARK 465 SER J 446 REMARK 465 PRO J 447 REMARK 465 GLY J 448 REMARK 465 LYS J 449 REMARK 465 ALA N 154 REMARK 465 LEU N 155 REMARK 465 GLN N 156 REMARK 465 SER N 157 REMARK 465 GLU N 214 REMARK 465 CYS N 215 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 VAL H 48 -61.39 -102.34 REMARK 500 PRO L 142 -178.60 -67.57 REMARK 500 ALA L 185 -6.31 71.51 REMARK 500 SER C 45 -162.17 -78.07 REMARK 500 ILE C 100 -61.59 -103.78 REMARK 500 SER C 112 -22.17 -140.41 REMARK 500 THR C 114 71.68 58.71 REMARK 500 SER C 116 135.77 -170.56 REMARK 500 ASN C 122 -167.61 -79.34 REMARK 500 VAL C 227 -68.61 -123.61 REMARK 500 ARG C 246 56.93 37.56 REMARK 500 ASN C 334 -9.46 73.34 REMARK 500 LEU C 335 7.37 55.24 REMARK 500 CYS C 336 81.89 51.62 REMARK 500 PRO C 337 17.48 -66.97 REMARK 500 ASN C 343 54.39 -92.32 REMARK 500 THR C 345 -4.30 67.00 REMARK 500 VAL C 362 -80.78 -85.37 REMARK 500 ALA C 363 -48.39 -146.29 REMARK 500 ASP C 364 51.10 32.20 REMARK 500 GLN C 409 15.45 50.25 REMARK 500 GLN C 414 -166.21 -79.76 REMARK 500 THR C 415 61.71 61.28 REMARK 500 PRO C 479 45.19 -79.19 REMARK 500 LYS C 535 -61.35 -93.88 REMARK 500 ASN C 536 56.68 -95.64 REMARK 500 LEU C 560 79.01 53.33 REMARK 500 PRO C 561 -9.13 -49.61 REMARK 500 CYS C 738 -12.74 73.32 REMARK 500 SER C 758 37.04 -99.55 REMARK 500 ALA C 783 30.56 -93.39 REMARK 500 PHE C 855 -166.64 -129.67 REMARK 500 LYS C 969 66.05 63.10 REMARK 500 ASP C1084 55.90 -98.60 REMARK 500 PRO C1143 49.93 -78.82 REMARK 500 PHE B 32 -162.58 -76.47 REMARK 500 THR B 33 92.27 -68.38 REMARK 500 THR B 95 59.18 -91.08 REMARK 500 SER B 98 -61.90 -120.83 REMARK 500 ASN B 99 31.18 -144.16 REMARK 500 THR B 114 70.02 58.55 REMARK 500 ASN B 122 -167.22 -78.51 REMARK 500 SER B 155 24.25 -140.64 REMARK 500 LEU B 216 75.12 53.32 REMARK 500 VAL B 362 -75.18 -81.52 REMARK 500 ALA B 363 -60.34 -128.64 REMARK 500 ASP B 364 47.67 36.96 REMARK 500 TYR B 380 -158.73 -141.66 REMARK 500 GLN B 409 25.00 45.40 REMARK 500 ASN B 448 -1.12 67.21 REMARK 500 REMARK 500 THIS ENTRY HAS 84 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-62680 RELATED DB: EMDB REMARK 900 STRUCTURE OF SARS-COV-2 EG.5.1 VARIANT SPIKE PROTEIN COMPLEXED WITH REMARK 900 ANTIBODY XGI-171 REMARK 900 RELATED ID: EMD-62660 RELATED DB: EMDB REMARK 900 RELATED ID: 9KZD RELATED DB: PDB DBREF 9KZZ H 1 449 PDB 9KZZ 9KZZ 1 449 DBREF 9KZZ L 1 215 PDB 9KZZ 9KZZ 1 215 DBREF 9KZZ C 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9KZZ B 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9KZZ A 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9KZZ I 1 449 PDB 9KZZ 9KZZ 1 449 DBREF 9KZZ M 1 215 PDB 9KZZ 9KZZ 1 215 DBREF 9KZZ J 1 449 PDB 9KZZ 9KZZ 1 449 DBREF 9KZZ N 1 215 PDB 9KZZ 9KZZ 1 215 SEQADV 9KZZ MET C -10 UNP P0DTC2 INITIATING METHIONINE SEQADV 9KZZ PRO C -9 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET C -8 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C -7 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C -6 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C -5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN C -4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO C -3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA C -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ THR C 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR C 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET C 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL C 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA C 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL C 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA C 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ILE C 19 UNP P0DTC2 THR 19 VARIANT SEQADV 9KZZ C UNP P0DTC2 LEU 24 DELETION SEQADV 9KZZ C UNP P0DTC2 PRO 25 DELETION SEQADV 9KZZ C UNP P0DTC2 PRO 26 DELETION SEQADV 9KZZ SER C 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 9KZZ HIS C 52 UNP P0DTC2 GLN 52 VARIANT SEQADV 9KZZ ALA C 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 9KZZ ASP C 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 9KZZ C UNP P0DTC2 TYR 144 DELETION SEQADV 9KZZ GLN C 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 9KZZ GLU C 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 9KZZ GLU C 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 9KZZ VAL C 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 9KZZ HIS C 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 9KZZ THR C 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 9KZZ ILE C 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 9KZZ PHE C 371 UNP P0DTC2 SER 371 VARIANT SEQADV 9KZZ PRO C 373 UNP P0DTC2 SER 373 VARIANT SEQADV 9KZZ PHE C 375 UNP P0DTC2 SER 375 VARIANT SEQADV 9KZZ ALA C 376 UNP P0DTC2 THR 376 VARIANT SEQADV 9KZZ ASN C 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 9KZZ SER C 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 9KZZ ASN C 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 9KZZ LYS C 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 9KZZ PRO C 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 9KZZ SER C 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 9KZZ LEU C 456 UNP P0DTC2 PHE 456 VARIANT SEQADV 9KZZ LYS C 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 9KZZ ASN C 477 UNP P0DTC2 SER 477 VARIANT SEQADV 9KZZ LYS C 478 UNP P0DTC2 THR 478 VARIANT SEQADV 9KZZ ALA C 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 9KZZ PRO C 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 9KZZ SER C 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 9KZZ ARG C 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 9KZZ TYR C 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 9KZZ HIS C 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 9KZZ GLY C 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 9KZZ TYR C 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 9KZZ LYS C 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 9KZZ HIS C 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 9KZZ GLY C 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9KZZ SER C 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9KZZ SER C 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9KZZ LYS C 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 9KZZ TYR C 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 9KZZ PRO C 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9KZZ PRO C 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9KZZ PRO C 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9KZZ PRO C 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9KZZ HIS C 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 9KZZ LYS C 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 9KZZ PRO C 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 9KZZ PRO C 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 9KZZ GLY C 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR C 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ILE C 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO C 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU C 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA C 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO C 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ARG C 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ASP C 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN C 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA C 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR C 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL C 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ARG C 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS C 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ASP C 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU C 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP C 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL C 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE C 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ THR C 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE C 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU C 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL C 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU C 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE C 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN C 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO C 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP C 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO C 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN C 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE C 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU C 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS C 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA C 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP C 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO C 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN C 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE C 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU C 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS C 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY C 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER C 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS C 1288 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET B -10 UNP P0DTC2 INITIATING METHIONINE SEQADV 9KZZ PRO B -9 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET B -8 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B -7 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B -6 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B -5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN B -4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO B -3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA B -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ THR B 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR B 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET B 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL B 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA B 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL B 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA B 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ILE B 19 UNP P0DTC2 THR 19 VARIANT SEQADV 9KZZ B UNP P0DTC2 LEU 24 DELETION SEQADV 9KZZ B UNP P0DTC2 PRO 25 DELETION SEQADV 9KZZ B UNP P0DTC2 PRO 26 DELETION SEQADV 9KZZ SER B 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 9KZZ HIS B 52 UNP P0DTC2 GLN 52 VARIANT SEQADV 9KZZ ALA B 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 9KZZ ASP B 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 9KZZ B UNP P0DTC2 TYR 144 DELETION SEQADV 9KZZ GLN B 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 9KZZ GLU B 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 9KZZ GLU B 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 9KZZ VAL B 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 9KZZ HIS B 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 9KZZ THR B 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 9KZZ ILE B 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 9KZZ PHE B 371 UNP P0DTC2 SER 371 VARIANT SEQADV 9KZZ PRO B 373 UNP P0DTC2 SER 373 VARIANT SEQADV 9KZZ PHE B 375 UNP P0DTC2 SER 375 VARIANT SEQADV 9KZZ ALA B 376 UNP P0DTC2 THR 376 VARIANT SEQADV 9KZZ ASN B 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 9KZZ SER B 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 9KZZ ASN B 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 9KZZ LYS B 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 9KZZ PRO B 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 9KZZ SER B 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 9KZZ LEU B 456 UNP P0DTC2 PHE 456 VARIANT SEQADV 9KZZ LYS B 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 9KZZ ASN B 477 UNP P0DTC2 SER 477 VARIANT SEQADV 9KZZ LYS B 478 UNP P0DTC2 THR 478 VARIANT SEQADV 9KZZ ALA B 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 9KZZ PRO B 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 9KZZ SER B 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 9KZZ ARG B 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 9KZZ TYR B 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 9KZZ HIS B 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 9KZZ GLY B 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 9KZZ TYR B 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 9KZZ LYS B 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 9KZZ HIS B 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 9KZZ GLY B 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9KZZ SER B 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9KZZ SER B 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9KZZ LYS B 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 9KZZ TYR B 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 9KZZ PRO B 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9KZZ PRO B 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9KZZ PRO B 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9KZZ PRO B 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9KZZ HIS B 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 9KZZ LYS B 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 9KZZ PRO B 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 9KZZ PRO B 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 9KZZ GLY B 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR B 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ILE B 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO B 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU B 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA B 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO B 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ARG B 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ASP B 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN B 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA B 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR B 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL B 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ARG B 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS B 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ASP B 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU B 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP B 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL B 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE B 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ THR B 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE B 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU B 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL B 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU B 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE B 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN B 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO B 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP B 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO B 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN B 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE B 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU B 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS B 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA B 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP B 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO B 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN B 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE B 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU B 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS B 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY B 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER B 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS B 1288 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET A -10 UNP P0DTC2 INITIATING METHIONINE SEQADV 9KZZ PRO A -9 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET A -8 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A -7 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A -6 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A -5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN A -4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO A -3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA A -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ THR A 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR A 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ MET A 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL A 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA A 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL A 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA A 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ILE A 19 UNP P0DTC2 THR 19 VARIANT SEQADV 9KZZ A UNP P0DTC2 LEU 24 DELETION SEQADV 9KZZ A UNP P0DTC2 PRO 25 DELETION SEQADV 9KZZ A UNP P0DTC2 PRO 26 DELETION SEQADV 9KZZ SER A 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 9KZZ HIS A 52 UNP P0DTC2 GLN 52 VARIANT SEQADV 9KZZ ALA A 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 9KZZ ASP A 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 9KZZ A UNP P0DTC2 TYR 144 DELETION SEQADV 9KZZ GLN A 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 9KZZ GLU A 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 9KZZ GLU A 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 9KZZ VAL A 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 9KZZ HIS A 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 9KZZ THR A 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 9KZZ ILE A 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 9KZZ PHE A 371 UNP P0DTC2 SER 371 VARIANT SEQADV 9KZZ PRO A 373 UNP P0DTC2 SER 373 VARIANT SEQADV 9KZZ PHE A 375 UNP P0DTC2 SER 375 VARIANT SEQADV 9KZZ ALA A 376 UNP P0DTC2 THR 376 VARIANT SEQADV 9KZZ ASN A 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 9KZZ SER A 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 9KZZ ASN A 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 9KZZ LYS A 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 9KZZ PRO A 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 9KZZ SER A 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 9KZZ LEU A 456 UNP P0DTC2 PHE 456 VARIANT SEQADV 9KZZ LYS A 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 9KZZ ASN A 477 UNP P0DTC2 SER 477 VARIANT SEQADV 9KZZ LYS A 478 UNP P0DTC2 THR 478 VARIANT SEQADV 9KZZ ALA A 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 9KZZ PRO A 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 9KZZ SER A 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 9KZZ ARG A 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 9KZZ TYR A 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 9KZZ HIS A 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 9KZZ GLY A 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 9KZZ TYR A 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 9KZZ LYS A 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 9KZZ HIS A 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 9KZZ GLY A 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9KZZ SER A 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9KZZ SER A 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9KZZ LYS A 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 9KZZ TYR A 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 9KZZ PRO A 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9KZZ PRO A 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9KZZ PRO A 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9KZZ PRO A 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9KZZ HIS A 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 9KZZ LYS A 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 9KZZ PRO A 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 9KZZ PRO A 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 9KZZ GLY A 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR A 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ILE A 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ARG A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ASP A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TYR A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ARG A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ASP A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ THR A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ VAL A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LEU A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ ALA A 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ TRP A 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PRO A 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLN A 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ PHE A 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLU A 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ LYS A 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ GLY A 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ SER A 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 9KZZ HIS A 1288 UNP P0DTC2 EXPRESSION TAG SEQRES 1 H 449 GLU VAL GLN LEU ALA GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 H 449 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 H 449 PHE THR PHE SER THR TYR ASP MET HIS TRP VAL ARG GLN SEQRES 4 H 449 VAL THR GLY ASN GLY LEU GLU TRP VAL SER THR ILE GLY SEQRES 5 H 449 THR GLY GLY ASP THR TYR TYR SER ASP SER VAL LYS GLY SEQRES 6 H 449 ARG PHE THR VAL SER ARG GLU ASN ALA LYS ASN ALA LEU SEQRES 7 H 449 PHE LEU GLN ILE ASN GLY LEU ARG ALA GLY ASP THR ALA SEQRES 8 H 449 VAL TYR TYR CYS ALA ARG GLY GLY SER GLY GLN PHE TRP SEQRES 9 H 449 TYR PHE ASP LEU TRP GLY ARG GLY THR LEU VAL THR VAL SEQRES 10 H 449 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 H 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 H 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 H 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 H 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 H 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 H 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 H 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 H 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 H 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 H 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 H 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 H 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 H 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 H 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 H 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 H 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 H 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 H 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 H 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 H 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 H 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 H 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 H 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 H 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 H 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 L 215 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 215 SER LEU GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 215 GLN THR ILE GLY ARG PHE LEU ASN TRP TYR GLN GLN LYS SEQRES 4 L 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR GLY ALA SER SEQRES 5 L 215 SER LEU GLN ILE GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 215 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 L 215 TYR SER MET PRO PRO VAL THR PHE GLY GLN GLY THR ARG SEQRES 9 L 215 LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 L 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 L 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 L 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 L 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 L 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 L 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 L 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 L 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 C 1295 MET PRO MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR SEQRES 2 C 1295 LEU LEU GLY MET LEU VAL ALA SER VAL LEU ALA GLN CYS SEQRES 3 C 1295 VAL ASN LEU ILE THR ARG THR GLN SER TYR THR ASN SER SEQRES 4 C 1295 PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SEQRES 5 C 1295 SER SER VAL LEU HIS SER THR HIS ASP LEU PHE LEU PRO SEQRES 6 C 1295 PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SEQRES 7 C 1295 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO ALA SEQRES 8 C 1295 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 9 C 1295 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 10 C 1295 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 11 C 1295 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 12 C 1295 CYS ASN ASP PRO PHE LEU ASP VAL TYR GLN LYS ASN ASN SEQRES 13 C 1295 LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SER SEQRES 14 C 1295 ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO PHE SEQRES 15 C 1295 LEU MET ASP LEU GLU GLY LYS GLU GLY ASN PHE LYS ASN SEQRES 16 C 1295 LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE SEQRES 17 C 1295 LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU GLU ARG SEQRES 18 C 1295 ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU VAL SEQRES 19 C 1295 ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN THR SEQRES 20 C 1295 LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO VAL ASP SEQRES 21 C 1295 SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR TYR SEQRES 22 C 1295 VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS TYR SEQRES 23 C 1295 ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS ALA SEQRES 24 C 1295 LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SER SEQRES 25 C 1295 PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN PHE SEQRES 26 C 1295 ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO ASN SEQRES 27 C 1295 ILE THR ASN LEU CYS PRO PHE HIS GLU VAL PHE ASN ALA SEQRES 28 C 1295 THR THR PHE ALA SER VAL TYR ALA TRP ASN ARG LYS ARG SEQRES 29 C 1295 ILE SER ASN CYS VAL ALA ASP TYR SER VAL ILE TYR ASN SEQRES 30 C 1295 PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SER SEQRES 31 C 1295 PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL TYR SEQRES 32 C 1295 ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER GLN SEQRES 33 C 1295 ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR ASN SEQRES 34 C 1295 TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE ALA SEQRES 35 C 1295 TRP ASN SER ASN LYS LEU ASP SER LYS PRO SER GLY ASN SEQRES 36 C 1295 TYR ASN TYR LEU TYR ARG LEU LEU ARG LYS SER LYS LEU SEQRES 37 C 1295 LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR GLN SEQRES 38 C 1295 ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY PRO ASN SEQRES 39 C 1295 CYS TYR SER PRO LEU GLN SER TYR GLY PHE ARG PRO THR SEQRES 40 C 1295 TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL LEU SEQRES 41 C 1295 SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS GLY SEQRES 42 C 1295 PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS VAL SEQRES 43 C 1295 ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL LEU SEQRES 44 C 1295 THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE SEQRES 45 C 1295 GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG ASP SEQRES 46 C 1295 PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SER SEQRES 47 C 1295 PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN THR SEQRES 48 C 1295 SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS SEQRES 49 C 1295 THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU THR SEQRES 50 C 1295 PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL PHE SEQRES 51 C 1295 GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR VAL SEQRES 52 C 1295 ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY SEQRES 53 C 1295 ILE CYS ALA SER TYR GLN THR GLN THR LYS SER HIS GLY SEQRES 54 C 1295 SER ALA SER SER VAL ALA SER GLN SER ILE ILE ALA TYR SEQRES 55 C 1295 THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SER SEQRES 56 C 1295 ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SER SEQRES 57 C 1295 VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS THR SEQRES 58 C 1295 SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER THR SEQRES 59 C 1295 GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE CYS SEQRES 60 C 1295 THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL GLU SEQRES 61 C 1295 GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL LYS SEQRES 62 C 1295 GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY GLY SEQRES 63 C 1295 PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS PRO SEQRES 64 C 1295 SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN LYS SEQRES 65 C 1295 VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY SEQRES 66 C 1295 ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS SEQRES 67 C 1295 ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO LEU SEQRES 68 C 1295 LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA LEU SEQRES 69 C 1295 LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY ALA SEQRES 70 C 1295 GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET ALA SEQRES 71 C 1295 TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL LEU SEQRES 72 C 1295 TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SER SEQRES 73 C 1295 ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR PRO SEQRES 74 C 1295 SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS ASN SEQRES 75 C 1295 ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SER SEQRES 76 C 1295 LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE LEU SEQRES 77 C 1295 SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP SEQRES 78 C 1295 ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR TYR SEQRES 79 C 1295 VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SEQRES 80 C 1295 SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS VAL SEQRES 81 C 1295 LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS GLY SEQRES 82 C 1295 TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS GLY SEQRES 83 C 1295 VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN GLU SEQRES 84 C 1295 LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP GLY SEQRES 85 C 1295 LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER ASN SEQRES 86 C 1295 GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR GLU SEQRES 87 C 1295 PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER GLY SEQRES 88 C 1295 ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR VAL SEQRES 89 C 1295 TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS GLU SEQRES 90 C 1295 GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO ASP SEQRES 91 C 1295 VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER VAL SEQRES 92 C 1295 VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL SEQRES 93 C 1295 ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN GLU SEQRES 94 C 1295 LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO GLU SEQRES 95 C 1295 ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY SEQRES 96 C 1295 GLU TRP VAL PHE LEU SER THR PHE LEU SER GLY LEU GLU SEQRES 97 C 1295 VAL LEU PHE GLN GLY PRO GLY GLY TRP SER HIS PRO GLN SEQRES 98 C 1295 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY SEQRES 99 C 1295 SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SER SEQRES 100 C 1295 HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 B 1295 MET PRO MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR SEQRES 2 B 1295 LEU LEU GLY MET LEU VAL ALA SER VAL LEU ALA GLN CYS SEQRES 3 B 1295 VAL ASN LEU ILE THR ARG THR GLN SER TYR THR ASN SER SEQRES 4 B 1295 PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SEQRES 5 B 1295 SER SER VAL LEU HIS SER THR HIS ASP LEU PHE LEU PRO SEQRES 6 B 1295 PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SEQRES 7 B 1295 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO ALA SEQRES 8 B 1295 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 9 B 1295 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 10 B 1295 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 11 B 1295 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 12 B 1295 CYS ASN ASP PRO PHE LEU ASP VAL TYR GLN LYS ASN ASN SEQRES 13 B 1295 LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SER SEQRES 14 B 1295 ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO PHE SEQRES 15 B 1295 LEU MET ASP LEU GLU GLY LYS GLU GLY ASN PHE LYS ASN SEQRES 16 B 1295 LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE SEQRES 17 B 1295 LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU GLU ARG SEQRES 18 B 1295 ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU VAL SEQRES 19 B 1295 ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN THR SEQRES 20 B 1295 LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO VAL ASP SEQRES 21 B 1295 SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR TYR SEQRES 22 B 1295 VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS TYR SEQRES 23 B 1295 ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS ALA SEQRES 24 B 1295 LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SER SEQRES 25 B 1295 PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN PHE SEQRES 26 B 1295 ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO ASN SEQRES 27 B 1295 ILE THR ASN LEU CYS PRO PHE HIS GLU VAL PHE ASN ALA SEQRES 28 B 1295 THR THR PHE ALA SER VAL TYR ALA TRP ASN ARG LYS ARG SEQRES 29 B 1295 ILE SER ASN CYS VAL ALA ASP TYR SER VAL ILE TYR ASN SEQRES 30 B 1295 PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SER SEQRES 31 B 1295 PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL TYR SEQRES 32 B 1295 ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER GLN SEQRES 33 B 1295 ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR ASN SEQRES 34 B 1295 TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE ALA SEQRES 35 B 1295 TRP ASN SER ASN LYS LEU ASP SER LYS PRO SER GLY ASN SEQRES 36 B 1295 TYR ASN TYR LEU TYR ARG LEU LEU ARG LYS SER LYS LEU SEQRES 37 B 1295 LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR GLN SEQRES 38 B 1295 ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY PRO ASN SEQRES 39 B 1295 CYS TYR SER PRO LEU GLN SER TYR GLY PHE ARG PRO THR SEQRES 40 B 1295 TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL LEU SEQRES 41 B 1295 SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS GLY SEQRES 42 B 1295 PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS VAL SEQRES 43 B 1295 ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL LEU SEQRES 44 B 1295 THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE SEQRES 45 B 1295 GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG ASP SEQRES 46 B 1295 PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SER SEQRES 47 B 1295 PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN THR SEQRES 48 B 1295 SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS SEQRES 49 B 1295 THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU THR SEQRES 50 B 1295 PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL PHE SEQRES 51 B 1295 GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR VAL SEQRES 52 B 1295 ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY SEQRES 53 B 1295 ILE CYS ALA SER TYR GLN THR GLN THR LYS SER HIS GLY SEQRES 54 B 1295 SER ALA SER SER VAL ALA SER GLN SER ILE ILE ALA TYR SEQRES 55 B 1295 THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SER SEQRES 56 B 1295 ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SER SEQRES 57 B 1295 VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS THR SEQRES 58 B 1295 SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER THR SEQRES 59 B 1295 GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE CYS SEQRES 60 B 1295 THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL GLU SEQRES 61 B 1295 GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL LYS SEQRES 62 B 1295 GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY GLY SEQRES 63 B 1295 PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS PRO SEQRES 64 B 1295 SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN LYS SEQRES 65 B 1295 VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY SEQRES 66 B 1295 ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS SEQRES 67 B 1295 ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO LEU SEQRES 68 B 1295 LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA LEU SEQRES 69 B 1295 LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY ALA SEQRES 70 B 1295 GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET ALA SEQRES 71 B 1295 TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL LEU SEQRES 72 B 1295 TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SER SEQRES 73 B 1295 ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR PRO SEQRES 74 B 1295 SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS ASN SEQRES 75 B 1295 ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SER SEQRES 76 B 1295 LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE LEU SEQRES 77 B 1295 SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP SEQRES 78 B 1295 ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR TYR SEQRES 79 B 1295 VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SEQRES 80 B 1295 SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS VAL SEQRES 81 B 1295 LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS GLY SEQRES 82 B 1295 TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS GLY SEQRES 83 B 1295 VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN GLU SEQRES 84 B 1295 LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP GLY SEQRES 85 B 1295 LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER ASN SEQRES 86 B 1295 GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR GLU SEQRES 87 B 1295 PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER GLY SEQRES 88 B 1295 ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR VAL SEQRES 89 B 1295 TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS GLU SEQRES 90 B 1295 GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO ASP SEQRES 91 B 1295 VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER VAL SEQRES 92 B 1295 VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL SEQRES 93 B 1295 ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN GLU SEQRES 94 B 1295 LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO GLU SEQRES 95 B 1295 ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY SEQRES 96 B 1295 GLU TRP VAL PHE LEU SER THR PHE LEU SER GLY LEU GLU SEQRES 97 B 1295 VAL LEU PHE GLN GLY PRO GLY GLY TRP SER HIS PRO GLN SEQRES 98 B 1295 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY SEQRES 99 B 1295 SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SER SEQRES 100 B 1295 HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 A 1295 MET PRO MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR SEQRES 2 A 1295 LEU LEU GLY MET LEU VAL ALA SER VAL LEU ALA GLN CYS SEQRES 3 A 1295 VAL ASN LEU ILE THR ARG THR GLN SER TYR THR ASN SER SEQRES 4 A 1295 PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SEQRES 5 A 1295 SER SER VAL LEU HIS SER THR HIS ASP LEU PHE LEU PRO SEQRES 6 A 1295 PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SEQRES 7 A 1295 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO ALA SEQRES 8 A 1295 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 9 A 1295 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 10 A 1295 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 11 A 1295 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 12 A 1295 CYS ASN ASP PRO PHE LEU ASP VAL TYR GLN LYS ASN ASN SEQRES 13 A 1295 LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SER SEQRES 14 A 1295 ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO PHE SEQRES 15 A 1295 LEU MET ASP LEU GLU GLY LYS GLU GLY ASN PHE LYS ASN SEQRES 16 A 1295 LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE SEQRES 17 A 1295 LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU GLU ARG SEQRES 18 A 1295 ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU VAL SEQRES 19 A 1295 ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN THR SEQRES 20 A 1295 LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO VAL ASP SEQRES 21 A 1295 SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR TYR SEQRES 22 A 1295 VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS TYR SEQRES 23 A 1295 ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS ALA SEQRES 24 A 1295 LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SER SEQRES 25 A 1295 PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN PHE SEQRES 26 A 1295 ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO ASN SEQRES 27 A 1295 ILE THR ASN LEU CYS PRO PHE HIS GLU VAL PHE ASN ALA SEQRES 28 A 1295 THR THR PHE ALA SER VAL TYR ALA TRP ASN ARG LYS ARG SEQRES 29 A 1295 ILE SER ASN CYS VAL ALA ASP TYR SER VAL ILE TYR ASN SEQRES 30 A 1295 PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SER SEQRES 31 A 1295 PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL TYR SEQRES 32 A 1295 ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER GLN SEQRES 33 A 1295 ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR ASN SEQRES 34 A 1295 TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE ALA SEQRES 35 A 1295 TRP ASN SER ASN LYS LEU ASP SER LYS PRO SER GLY ASN SEQRES 36 A 1295 TYR ASN TYR LEU TYR ARG LEU LEU ARG LYS SER LYS LEU SEQRES 37 A 1295 LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR GLN SEQRES 38 A 1295 ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY PRO ASN SEQRES 39 A 1295 CYS TYR SER PRO LEU GLN SER TYR GLY PHE ARG PRO THR SEQRES 40 A 1295 TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL LEU SEQRES 41 A 1295 SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS GLY SEQRES 42 A 1295 PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS VAL SEQRES 43 A 1295 ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL LEU SEQRES 44 A 1295 THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE SEQRES 45 A 1295 GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG ASP SEQRES 46 A 1295 PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SER SEQRES 47 A 1295 PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN THR SEQRES 48 A 1295 SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS SEQRES 49 A 1295 THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU THR SEQRES 50 A 1295 PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL PHE SEQRES 51 A 1295 GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR VAL SEQRES 52 A 1295 ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY SEQRES 53 A 1295 ILE CYS ALA SER TYR GLN THR GLN THR LYS SER HIS GLY SEQRES 54 A 1295 SER ALA SER SER VAL ALA SER GLN SER ILE ILE ALA TYR SEQRES 55 A 1295 THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SER SEQRES 56 A 1295 ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SER SEQRES 57 A 1295 VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS THR SEQRES 58 A 1295 SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER THR SEQRES 59 A 1295 GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE CYS SEQRES 60 A 1295 THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL GLU SEQRES 61 A 1295 GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL LYS SEQRES 62 A 1295 GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY GLY SEQRES 63 A 1295 PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS PRO SEQRES 64 A 1295 SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN LYS SEQRES 65 A 1295 VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY SEQRES 66 A 1295 ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS SEQRES 67 A 1295 ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO LEU SEQRES 68 A 1295 LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA LEU SEQRES 69 A 1295 LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY ALA SEQRES 70 A 1295 GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET ALA SEQRES 71 A 1295 TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL LEU SEQRES 72 A 1295 TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SER SEQRES 73 A 1295 ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR PRO SEQRES 74 A 1295 SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS ASN SEQRES 75 A 1295 ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SER SEQRES 76 A 1295 LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE LEU SEQRES 77 A 1295 SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP SEQRES 78 A 1295 ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR TYR SEQRES 79 A 1295 VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SEQRES 80 A 1295 SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS VAL SEQRES 81 A 1295 LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS GLY SEQRES 82 A 1295 TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS GLY SEQRES 83 A 1295 VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN GLU SEQRES 84 A 1295 LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP GLY SEQRES 85 A 1295 LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER ASN SEQRES 86 A 1295 GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR GLU SEQRES 87 A 1295 PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER GLY SEQRES 88 A 1295 ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR VAL SEQRES 89 A 1295 TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS GLU SEQRES 90 A 1295 GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO ASP SEQRES 91 A 1295 VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER VAL SEQRES 92 A 1295 VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL SEQRES 93 A 1295 ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN GLU SEQRES 94 A 1295 LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO GLU SEQRES 95 A 1295 ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY SEQRES 96 A 1295 GLU TRP VAL PHE LEU SER THR PHE LEU SER GLY LEU GLU SEQRES 97 A 1295 VAL LEU PHE GLN GLY PRO GLY GLY TRP SER HIS PRO GLN SEQRES 98 A 1295 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY SEQRES 99 A 1295 SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SER SEQRES 100 A 1295 HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 I 449 GLU VAL GLN LEU ALA GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 I 449 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 I 449 PHE THR PHE SER THR TYR ASP MET HIS TRP VAL ARG GLN SEQRES 4 I 449 VAL THR GLY ASN GLY LEU GLU TRP VAL SER THR ILE GLY SEQRES 5 I 449 THR GLY GLY ASP THR TYR TYR SER ASP SER VAL LYS GLY SEQRES 6 I 449 ARG PHE THR VAL SER ARG GLU ASN ALA LYS ASN ALA LEU SEQRES 7 I 449 PHE LEU GLN ILE ASN GLY LEU ARG ALA GLY ASP THR ALA SEQRES 8 I 449 VAL TYR TYR CYS ALA ARG GLY GLY SER GLY GLN PHE TRP SEQRES 9 I 449 TYR PHE ASP LEU TRP GLY ARG GLY THR LEU VAL THR VAL SEQRES 10 I 449 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 I 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 I 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 I 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 I 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 I 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 I 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 I 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 I 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 I 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 I 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 I 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 I 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 I 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 I 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 I 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 I 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 I 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 I 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 I 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 I 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 I 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 I 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 I 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 I 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 I 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 M 215 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 M 215 SER LEU GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 M 215 GLN THR ILE GLY ARG PHE LEU ASN TRP TYR GLN GLN LYS SEQRES 4 M 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR GLY ALA SER SEQRES 5 M 215 SER LEU GLN ILE GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 M 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 M 215 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 M 215 TYR SER MET PRO PRO VAL THR PHE GLY GLN GLY THR ARG SEQRES 9 M 215 LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 M 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 M 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 M 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 M 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 M 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 M 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 M 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 M 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 J 449 GLU VAL GLN LEU ALA GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 J 449 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 J 449 PHE THR PHE SER THR TYR ASP MET HIS TRP VAL ARG GLN SEQRES 4 J 449 VAL THR GLY ASN GLY LEU GLU TRP VAL SER THR ILE GLY SEQRES 5 J 449 THR GLY GLY ASP THR TYR TYR SER ASP SER VAL LYS GLY SEQRES 6 J 449 ARG PHE THR VAL SER ARG GLU ASN ALA LYS ASN ALA LEU SEQRES 7 J 449 PHE LEU GLN ILE ASN GLY LEU ARG ALA GLY ASP THR ALA SEQRES 8 J 449 VAL TYR TYR CYS ALA ARG GLY GLY SER GLY GLN PHE TRP SEQRES 9 J 449 TYR PHE ASP LEU TRP GLY ARG GLY THR LEU VAL THR VAL SEQRES 10 J 449 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 J 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 J 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 J 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 J 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 J 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 J 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 J 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 J 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 J 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 J 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 J 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 J 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 J 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 J 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 J 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 J 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 J 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 J 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 J 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 J 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 J 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 J 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 J 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 J 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 J 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 N 215 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 N 215 SER LEU GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 N 215 GLN THR ILE GLY ARG PHE LEU ASN TRP TYR GLN GLN LYS SEQRES 4 N 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR GLY ALA SER SEQRES 5 N 215 SER LEU GLN ILE GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 N 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 N 215 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN SER SEQRES 8 N 215 TYR SER MET PRO PRO VAL THR PHE GLY GLN GLY THR ARG SEQRES 9 N 215 LEU GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 N 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 N 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 N 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 N 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 N 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 N 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 N 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 N 215 SER PHE ASN ARG GLY GLU CYS HET NAG D 1 14 HET NAG D 2 14 HET NAG E 1 14 HET NAG E 2 14 HET BMA E 3 11 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET BMA G 3 11 HET NAG K 1 14 HET NAG K 2 14 HET BMA K 3 11 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG X 1 14 HET NAG X 2 14 HET BMA X 3 11 HET NAG Y 1 14 HET NAG Y 2 14 HET BMA Y 3 11 HET NAG Z 1 14 HET NAG Z 2 14 HET BMA Z 3 11 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET BMA b 3 11 HET NAG c 1 14 HET NAG c 2 14 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET NAG e 1 14 HET NAG e 2 14 HET NAG f 1 14 HET NAG f 2 14 HET BMA f 3 11 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET NAG i 1 14 HET NAG i 2 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 65(C8 H15 N O6) FORMUL 11 BMA 10(C6 H12 O6) HELIX 1 AA1 THR H 28 TYR H 32 5 5 HELIX 2 AA2 ARG H 86 THR H 90 5 5 HELIX 3 AA3 SER H 162 ALA H 164 5 3 HELIX 4 AA4 SER L 122 LYS L 127 1 6 HELIX 5 AA5 ALA L 185 HIS L 190 1 6 HELIX 6 AA6 ASP C 294 LYS C 304 1 11 HELIX 7 AA7 PRO C 337 ASN C 343 1 7 HELIX 8 AA8 SER C 349 TRP C 353 5 5 HELIX 9 AA9 TYR C 365 ASN C 370 1 6 HELIX 10 AB1 SER C 383 LEU C 387 5 5 HELIX 11 AB2 ARG C 403 SER C 408 5 6 HELIX 12 AB3 PRO C 479 VAL C 483 5 5 HELIX 13 AB4 ASN C 616 VAL C 620 5 5 HELIX 14 AB5 CYS C 738 CYS C 743 1 6 HELIX 15 AB6 SER C 746 GLN C 755 1 10 HELIX 16 AB7 SER C 758 ALA C 783 1 26 HELIX 17 AB8 LYS C 811 ARG C 815 5 5 HELIX 18 AB9 SER C 816 VAL C 826 1 11 HELIX 19 AC1 THR C 866 SER C 884 1 19 HELIX 20 AC2 TRP C 886 GLY C 891 1 6 HELIX 21 AC3 PRO C 897 GLY C 910 1 14 HELIX 22 AC4 GLN C 913 GLU C 918 1 6 HELIX 23 AC5 ASN C 919 THR C 941 1 23 HELIX 24 AC6 LEU C 945 SER C 968 1 24 HELIX 25 AC7 VAL C 976 LEU C 984 1 9 HELIX 26 AC8 ASP C 985 CYS C 1032 1 48 HELIX 27 AC9 ASP B 294 LYS B 304 1 11 HELIX 28 AD1 PRO B 337 ASN B 343 1 7 HELIX 29 AD2 SER B 349 TRP B 353 5 5 HELIX 30 AD3 TYR B 365 PHE B 371 1 7 HELIX 31 AD4 SER B 383 LEU B 387 5 5 HELIX 32 AD5 ASN B 405 SER B 408 5 4 HELIX 33 AD6 GLY B 416 ASN B 422 1 7 HELIX 34 AD7 PRO B 479 VAL B 483 5 5 HELIX 35 AD8 ASP B 737 CYS B 743 1 7 HELIX 36 AD9 SER B 746 GLN B 755 1 10 HELIX 37 AE1 SER B 758 ALA B 783 1 26 HELIX 38 AE2 LYS B 811 ARG B 815 5 5 HELIX 39 AE3 SER B 816 VAL B 826 1 11 HELIX 40 AE4 THR B 866 SER B 884 1 19 HELIX 41 AE5 TRP B 886 ALA B 890 5 5 HELIX 42 AE6 PRO B 897 ILE B 909 1 13 HELIX 43 AE7 THR B 912 ASN B 919 1 8 HELIX 44 AE8 ASN B 919 THR B 941 1 23 HELIX 45 AE9 LEU B 945 GLN B 965 1 21 HELIX 46 AF1 LEU B 966 SER B 968 5 3 HELIX 47 AF2 VAL B 976 LEU B 984 1 9 HELIX 48 AF3 ASP B 985 VAL B 1033 1 49 HELIX 49 AF4 ASP A 294 LEU A 303 1 10 HELIX 50 AF5 PRO A 337 ASN A 343 1 7 HELIX 51 AF6 ARG A 403 ILE A 410 5 8 HELIX 52 AF7 GLY A 416 ASN A 422 1 7 HELIX 53 AF8 PRO A 479 VAL A 483 5 5 HELIX 54 AF9 ILE A 569 ASP A 571 5 3 HELIX 55 AG1 ASP A 737 CYS A 743 1 7 HELIX 56 AG2 SER A 746 LEU A 753 1 8 HELIX 57 AG3 LEU A 754 GLY A 757 5 4 HELIX 58 AG4 SER A 758 PHE A 782 1 25 HELIX 59 AG5 SER A 816 VAL A 826 1 11 HELIX 60 AG6 THR A 866 SER A 884 1 19 HELIX 61 AG7 TRP A 886 GLY A 891 1 6 HELIX 62 AG8 PRO A 897 ILE A 909 1 13 HELIX 63 AG9 THR A 912 GLU A 918 1 7 HELIX 64 AH1 ASN A 919 THR A 941 1 23 HELIX 65 AH2 LEU A 945 GLN A 965 1 21 HELIX 66 AH3 LEU A 966 SER A 968 5 3 HELIX 67 AH4 VAL A 976 LEU A 981 1 6 HELIX 68 AH5 ALA A 989 VAL A 1033 1 45 HELIX 69 AH6 THR I 28 TYR I 32 5 5 HELIX 70 AH7 ARG I 86 THR I 90 5 5 HELIX 71 AH8 TRP I 160 ALA I 164 5 5 HELIX 72 AH9 SER M 122 SER M 128 1 7 HELIX 73 AI1 THR J 28 TYR J 32 5 5 HELIX 74 AI2 ARG J 86 THR J 90 5 5 HELIX 75 AI3 SER J 162 ALA J 164 5 3 HELIX 76 AI4 SER N 122 LYS N 127 1 6 HELIX 77 AI5 ASP N 186 HIS N 190 5 5 SHEET 1 AA1 4 GLN H 3 SER H 7 0 SHEET 2 AA1 4 LEU H 18 SER H 25 -1 O ALA H 23 N ALA H 5 SHEET 3 AA1 4 ALA H 77 ILE H 82 -1 O ILE H 82 N LEU H 18 SHEET 4 AA1 4 PHE H 67 ARG H 71 -1 N THR H 68 O GLN H 81 SHEET 1 AA2 6 LEU H 11 VAL H 12 0 SHEET 2 AA2 6 THR H 113 VAL H 117 1 O THR H 116 N VAL H 12 SHEET 3 AA2 6 ALA H 91 GLY H 98 -1 N TYR H 93 O THR H 113 SHEET 4 AA2 6 ASP H 33 GLN H 39 -1 N ASP H 33 O GLY H 98 SHEET 5 AA2 6 LEU H 45 ILE H 51 -1 O VAL H 48 N TRP H 36 SHEET 6 AA2 6 THR H 57 TYR H 59 -1 O TYR H 58 N THR H 50 SHEET 1 AA3 4 LEU H 11 VAL H 12 0 SHEET 2 AA3 4 THR H 113 VAL H 117 1 O THR H 116 N VAL H 12 SHEET 3 AA3 4 ALA H 91 GLY H 98 -1 N TYR H 93 O THR H 113 SHEET 4 AA3 4 PHE H 106 TRP H 109 -1 O LEU H 108 N ARG H 97 SHEET 1 AA4 4 SER H 126 PHE H 128 0 SHEET 2 AA4 4 ALA H 142 LYS H 149 -1 O LEU H 147 N PHE H 128 SHEET 3 AA4 4 SER H 185 VAL H 190 -1 O VAL H 188 N LEU H 144 SHEET 4 AA4 4 VAL H 169 THR H 171 -1 N HIS H 170 O VAL H 187 SHEET 1 AA5 3 SER H 159 TRP H 160 0 SHEET 2 AA5 3 ILE H 201 HIS H 206 -1 O ASN H 203 N SER H 159 SHEET 3 AA5 3 THR H 211 ARG H 216 -1 O VAL H 213 N VAL H 204 SHEET 1 AA6 2 VAL H 175 LEU H 176 0 SHEET 2 AA6 2 TYR H 182 SER H 183 -1 O SER H 183 N VAL H 175 SHEET 1 AA7 4 MET L 4 GLN L 6 0 SHEET 2 AA7 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AA7 4 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AA7 4 PHE L 62 SER L 67 -1 N SER L 65 O THR L 72 SHEET 1 AA8 6 SER L 10 ALA L 13 0 SHEET 2 AA8 6 THR L 103 ILE L 107 1 O ARG L 104 N LEU L 11 SHEET 3 AA8 6 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 103 SHEET 4 AA8 6 LEU L 33 GLN L 38 -1 N GLN L 38 O THR L 85 SHEET 5 AA8 6 LYS L 45 TYR L 49 -1 O LYS L 45 N GLN L 37 SHEET 6 AA8 6 SER L 53 LEU L 54 -1 O SER L 53 N TYR L 49 SHEET 1 AA9 4 SER L 115 PHE L 119 0 SHEET 2 AA9 4 SER L 132 PHE L 140 -1 O LEU L 136 N PHE L 117 SHEET 3 AA9 4 TYR L 174 THR L 181 -1 O LEU L 176 N LEU L 137 SHEET 4 AA9 4 SER L 163 VAL L 164 -1 N SER L 163 O SER L 177 SHEET 1 AB1 3 LYS L 146 VAL L 151 0 SHEET 2 AB1 3 VAL L 192 THR L 198 -1 O ALA L 194 N LYS L 150 SHEET 3 AB1 3 LYS L 208 ASN L 211 -1 O PHE L 210 N TYR L 193 SHEET 1 AB2 7 THR C 22 ASN C 30 0 SHEET 2 AB2 7 ASN C 61 ALA C 67 -1 O TRP C 64 N SER C 27 SHEET 3 AB2 7 ALA C 262 TYR C 269 -1 O ALA C 262 N ALA C 67 SHEET 4 AB2 7 VAL C 90 SER C 94 -1 N TYR C 91 O GLY C 268 SHEET 5 AB2 7 LEU C 189 LYS C 195 -1 O PHE C 192 N PHE C 92 SHEET 6 AB2 7 LYS C 202 THR C 208 -1 O LYS C 202 N LYS C 195 SHEET 7 AB2 7 GLU C 224 PRO C 225 -1 O GLU C 224 N SER C 205 SHEET 1 AB3 7 PHE C 43 ARG C 44 0 SHEET 2 AB3 7 PHE A 565 ARG A 567 1 O PHE A 565 N PHE C 43 SHEET 3 AB3 7 THR A 573 VAL A 576 -1 O ALA A 575 N GLY A 566 SHEET 4 AB3 7 LEU A 585 THR A 588 -1 O ILE A 587 N ASP A 574 SHEET 5 AB3 7 LEU A 546 GLU A 554 -1 N THR A 553 O ASP A 586 SHEET 6 AB3 7 CYS A 538 PHE A 543 -1 N VAL A 539 O GLY A 550 SHEET 7 AB3 7 GLU A 324 ARG A 328 1 N ILE A 326 O ASN A 540 SHEET 1 AB4 3 LEU C 48 PHE C 55 0 SHEET 2 AB4 3 GLN C 271 TYR C 279 -1 O PHE C 275 N THR C 51 SHEET 3 AB4 3 ILE C 285 ASP C 290 -1 O ASP C 287 N LYS C 278 SHEET 1 AB5 3 LEU C 84 PRO C 85 0 SHEET 2 AB5 3 ARG C 237 LEU C 244 -1 O PHE C 238 N LEU C 84 SHEET 3 AB5 3 ILE C 101 GLY C 107 -1 N ILE C 105 O GLN C 239 SHEET 1 AB6 3 LEU C 84 PRO C 85 0 SHEET 2 AB6 3 ARG C 237 LEU C 244 -1 O PHE C 238 N LEU C 84 SHEET 3 AB6 3 PHE C 140 ASP C 142 1 N LEU C 141 O LEU C 242 SHEET 1 AB7 3 VAL C 120 ASN C 121 0 SHEET 2 AB7 3 VAL C 126 ILE C 128 -1 O VAL C 127 N VAL C 120 SHEET 3 AB7 3 TYR C 170 SER C 172 -1 O TYR C 170 N ILE C 128 SHEET 1 AB8 2 GLU C 132 PHE C 133 0 SHEET 2 AB8 2 ALA C 163 ASN C 164 -1 O ASN C 164 N GLU C 132 SHEET 1 AB9 5 GLY C 311 ARG C 319 0 SHEET 2 AB9 5 PHE C 592 THR C 599 -1 O GLY C 593 N PHE C 318 SHEET 3 AB9 5 ALA C 609 GLN C 613 -1 O ALA C 609 N ILE C 598 SHEET 4 AB9 5 GLY C 648 ILE C 651 -1 O CYS C 649 N TYR C 612 SHEET 5 AB9 5 VAL C 642 THR C 645 -1 N PHE C 643 O LEU C 650 SHEET 1 AC1 7 SER C 325 ARG C 328 0 SHEET 2 AC1 7 CYS C 538 PHE C 543 1 O ASN C 540 N ILE C 326 SHEET 3 AC1 7 LEU C 546 GLU C 554 -1 O GLY C 548 N PHE C 541 SHEET 4 AC1 7 ILE C 584 THR C 588 -1 O ASP C 586 N THR C 553 SHEET 5 AC1 7 THR C 573 ARG C 577 -1 N ASP C 574 O ILE C 587 SHEET 6 AC1 7 PHE C 565 ARG C 567 -1 N GLY C 566 O ALA C 575 SHEET 7 AC1 7 VAL B 42 PHE B 43 1 O PHE B 43 N PHE C 565 SHEET 1 AC2 5 ASN C 354 ILE C 358 0 SHEET 2 AC2 5 ASN C 394 ILE C 402 -1 O ALA C 397 N LYS C 356 SHEET 3 AC2 5 TYR C 508 GLU C 516 -1 O VAL C 512 N ASP C 398 SHEET 4 AC2 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AC2 5 ALA C 376 CYS C 379 -1 N LYS C 378 O VAL C 433 SHEET 1 AC3 2 CYS C 391 PHE C 392 0 SHEET 2 AC3 2 VAL C 524 CYS C 525 -1 O VAL C 524 N PHE C 392 SHEET 1 AC4 4 GLU C 654 TYR C 655 0 SHEET 2 AC4 4 SER C 691 THR C 696 1 O ALA C 694 N GLU C 654 SHEET 3 AC4 4 ILE C 670 GLN C 675 -1 N CYS C 671 O TYR C 695 SHEET 4 AC4 4 ILE C 664 GLY C 667 -1 N ILE C 664 O ALA C 672 SHEET 1 AC5 2 GLU C 702 ASN C 703 0 SHEET 2 AC5 2 ILE B 788 TYR B 789 1 O ILE B 788 N ASN C 703 SHEET 1 AC6 3 SER C 711 PRO C 728 0 SHEET 2 AC6 3 GLY C1059 THR C1076 -1 O PHE C1075 N ILE C 712 SHEET 3 AC6 3 TYR C1047 ALA C1056 -1 N TYR C1047 O TYR C1067 SHEET 1 AC7 2 LYS C 733 VAL C 736 0 SHEET 2 AC7 2 LEU C 858 LEU C 861 -1 O LEU C 861 N LYS C 733 SHEET 1 AC8 2 GLN C 787 TYR C 789 0 SHEET 2 AC8 2 ALA A 701 ASN A 703 1 O ASN A 703 N ILE C 788 SHEET 1 AC9 4 THR C1120 ASN C1125 0 SHEET 2 AC9 4 LYS C1086 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AC9 4 ILE C1081 CYS C1082 -1 N ILE C1081 O HIS C1088 SHEET 4 AC9 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AD1 3 VAL C1094 SER C1097 0 SHEET 2 AD1 3 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 3 AD1 3 GLN C1113 ILE C1114 -1 O GLN C1113 N VAL C1104 SHEET 1 AD2 7 THR B 22 SER B 31 0 SHEET 2 AD2 7 SER B 60 HIS B 66 -1 O TRP B 64 N SER B 27 SHEET 3 AD2 7 TYR B 265 TYR B 269 -1 O TYR B 265 N PHE B 65 SHEET 4 AD2 7 VAL B 90 ALA B 93 -1 N ALA B 93 O TYR B 266 SHEET 5 AD2 7 GLU B 191 ILE B 197 -1 O PHE B 192 N PHE B 92 SHEET 6 AD2 7 TYR B 200 LYS B 206 -1 O LYS B 202 N LYS B 195 SHEET 7 AD2 7 GLU B 224 LEU B 229 -1 O LEU B 229 N PHE B 201 SHEET 1 AD3 3 LEU B 48 PHE B 55 0 SHEET 2 AD3 3 GLN B 271 TYR B 279 -1 O PHE B 275 N THR B 51 SHEET 3 AD3 3 ILE B 285 ASP B 290 -1 O ASP B 287 N LYS B 278 SHEET 1 AD4 6 LEU B 84 PRO B 85 0 SHEET 2 AD4 6 ARG B 237 LEU B 242 -1 O PHE B 238 N LEU B 84 SHEET 3 AD4 6 ILE B 101 GLY B 107 -1 N GLY B 107 O ARG B 237 SHEET 4 AD4 6 LEU B 117 ASN B 121 -1 O LEU B 117 N PHE B 106 SHEET 5 AD4 6 VAL B 126 LYS B 129 -1 O LYS B 129 N LEU B 118 SHEET 6 AD4 6 TYR B 170 SER B 172 -1 O TYR B 170 N ILE B 128 SHEET 1 AD5 5 GLY B 311 ARG B 319 0 SHEET 2 AD5 5 PHE B 592 THR B 599 -1 O GLY B 593 N PHE B 318 SHEET 3 AD5 5 ALA B 609 GLN B 613 -1 O ALA B 609 N ILE B 598 SHEET 4 AD5 5 GLY B 648 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AD5 5 VAL B 642 GLN B 644 -1 N PHE B 643 O LEU B 650 SHEET 1 AD6 7 GLU B 324 ARG B 328 0 SHEET 2 AD6 7 CYS B 538 PHE B 543 1 O ASN B 540 N ILE B 326 SHEET 3 AD6 7 LEU B 546 GLU B 554 -1 O LEU B 546 N PHE B 543 SHEET 4 AD6 7 ILE B 584 THR B 588 -1 O ASP B 586 N THR B 553 SHEET 5 AD6 7 THR B 573 ARG B 577 -1 N ASP B 574 O ILE B 587 SHEET 6 AD6 7 PHE B 565 ARG B 567 -1 N GLY B 566 O ASP B 574 SHEET 7 AD6 7 VAL A 42 PHE A 43 1 O PHE A 43 N PHE B 565 SHEET 1 AD7 5 ASN B 354 ILE B 358 0 SHEET 2 AD7 5 ASN B 394 ARG B 403 -1 O ALA B 397 N LYS B 356 SHEET 3 AD7 5 PRO B 507 GLU B 516 -1 O VAL B 512 N ASP B 398 SHEET 4 AD7 5 GLY B 431 ASN B 437 -1 N ILE B 434 O VAL B 511 SHEET 5 AD7 5 ALA B 376 CYS B 379 -1 N LYS B 378 O VAL B 433 SHEET 1 AD8 2 LEU B 452 TYR B 453 0 SHEET 2 AD8 2 GLN B 493 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AD9 4 GLU B 654 TYR B 655 0 SHEET 2 AD9 4 SER B 691 THR B 696 1 O ALA B 694 N GLU B 654 SHEET 3 AD9 4 ILE B 670 GLN B 675 -1 N CYS B 671 O TYR B 695 SHEET 4 AD9 4 ILE B 664 GLY B 667 -1 N ILE B 664 O ALA B 672 SHEET 1 AE1 2 GLU B 702 ASN B 703 0 SHEET 2 AE1 2 ILE A 788 TYR A 789 1 O ILE A 788 N ASN B 703 SHEET 1 AE2 3 SER B 711 PRO B 728 0 SHEET 2 AE2 3 GLY B1059 ALA B1078 -1 O PHE B1075 N ILE B 712 SHEET 3 AE2 3 TYR B1047 ALA B1056 -1 N LEU B1049 O VAL B1065 SHEET 1 AE3 4 SER B 711 PRO B 728 0 SHEET 2 AE3 4 GLY B1059 ALA B1078 -1 O PHE B1075 N ILE B 712 SHEET 3 AE3 4 VAL B1094 SER B1097 -1 O SER B1097 N THR B1076 SHEET 4 AE3 4 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 1 AE4 2 THR B 734 VAL B 736 0 SHEET 2 AE4 2 LEU B 858 VAL B 860 -1 O THR B 859 N SER B 735 SHEET 1 AE5 4 THR B1120 ASN B1125 0 SHEET 2 AE5 4 LYS B1086 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AE5 4 ILE B1081 CYS B1082 -1 N ILE B1081 O HIS B1088 SHEET 4 AE5 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AE6 7 SER A 27 ASN A 30 0 SHEET 2 AE6 7 ASN A 61 PHE A 65 -1 O TRP A 64 N SER A 27 SHEET 3 AE6 7 TYR A 265 TYR A 269 -1 O VAL A 267 N THR A 63 SHEET 4 AE6 7 GLY A 89 SER A 94 -1 N TYR A 91 O GLY A 268 SHEET 5 AE6 7 LEU A 189 ASN A 196 -1 O PHE A 192 N PHE A 92 SHEET 6 AE6 7 PHE A 201 THR A 208 -1 O THR A 208 N LEU A 189 SHEET 7 AE6 7 GLU A 224 PRO A 225 -1 O GLU A 224 N SER A 205 SHEET 1 AE7 3 LEU A 48 PHE A 55 0 SHEET 2 AE7 3 GLN A 271 TYR A 279 -1 O PHE A 275 N THR A 51 SHEET 3 AE7 3 ILE A 285 ASP A 290 -1 O VAL A 289 N LEU A 276 SHEET 1 AE8 6 LEU A 84 PRO A 85 0 SHEET 2 AE8 6 ARG A 237 LEU A 242 -1 O PHE A 238 N LEU A 84 SHEET 3 AE8 6 ILE A 101 GLY A 107 -1 N GLY A 103 O LEU A 241 SHEET 4 AE8 6 SER A 116 ASN A 121 -1 O LEU A 117 N PHE A 106 SHEET 5 AE8 6 VAL A 126 CYS A 131 -1 O CYS A 131 N SER A 116 SHEET 6 AE8 6 THR A 167 SER A 172 -1 O TYR A 170 N ILE A 128 SHEET 1 AE9 5 GLY A 311 ARG A 319 0 SHEET 2 AE9 5 PHE A 592 THR A 599 -1 O GLY A 593 N PHE A 318 SHEET 3 AE9 5 ALA A 609 GLN A 613 -1 O ALA A 609 N ILE A 598 SHEET 4 AE9 5 GLY A 648 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 5 AE9 5 VAL A 642 THR A 645 -1 N PHE A 643 O LEU A 650 SHEET 1 AF1 5 LYS A 356 ILE A 358 0 SHEET 2 AF1 5 ASN A 394 ILE A 402 -1 O ALA A 397 N LYS A 356 SHEET 3 AF1 5 TYR A 508 GLU A 516 -1 O VAL A 512 N ASP A 398 SHEET 4 AF1 5 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 5 AF1 5 ALA A 376 CYS A 379 -1 N LYS A 378 O VAL A 433 SHEET 1 AF2 4 GLU A 654 TYR A 655 0 SHEET 2 AF2 4 SER A 691 THR A 696 1 O ALA A 694 N GLU A 654 SHEET 3 AF2 4 ILE A 670 GLN A 675 -1 N CYS A 671 O TYR A 695 SHEET 4 AF2 4 ILE A 664 GLY A 667 -1 N ILE A 664 O ALA A 672 SHEET 1 AF3 3 SER A 711 PRO A 728 0 SHEET 2 AF3 3 GLY A1059 THR A1076 -1 O PHE A1075 N ILE A 712 SHEET 3 AF3 3 TYR A1047 ALA A1056 -1 N TYR A1047 O TYR A1067 SHEET 1 AF4 2 LYS A 733 VAL A 736 0 SHEET 2 AF4 2 LEU A 858 LEU A 861 -1 O THR A 859 N SER A 735 SHEET 1 AF5 4 THR A1120 ASN A1125 0 SHEET 2 AF5 4 LYS A1086 PRO A1090 -1 N PHE A1089 O PHE A1121 SHEET 3 AF5 4 ILE A1081 CYS A1082 -1 N ILE A1081 O HIS A1088 SHEET 4 AF5 4 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SHEET 1 AF6 2 VAL A1094 SER A1097 0 SHEET 2 AF6 2 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 1 AF7 4 GLN I 3 SER I 7 0 SHEET 2 AF7 4 LEU I 18 SER I 25 -1 O ALA I 23 N ALA I 5 SHEET 3 AF7 4 ALA I 77 ILE I 82 -1 O LEU I 78 N CYS I 22 SHEET 4 AF7 4 PHE I 67 ARG I 71 -1 N THR I 68 O GLN I 81 SHEET 1 AF8 6 LEU I 11 VAL I 12 0 SHEET 2 AF8 6 THR I 113 VAL I 117 1 O THR I 116 N VAL I 12 SHEET 3 AF8 6 ALA I 91 GLY I 98 -1 N TYR I 93 O THR I 113 SHEET 4 AF8 6 ASP I 33 GLN I 39 -1 N ASP I 33 O GLY I 98 SHEET 5 AF8 6 LEU I 45 ILE I 51 -1 O SER I 49 N TRP I 36 SHEET 6 AF8 6 THR I 57 TYR I 59 -1 O TYR I 58 N THR I 50 SHEET 1 AF9 4 LEU I 11 VAL I 12 0 SHEET 2 AF9 4 THR I 113 VAL I 117 1 O THR I 116 N VAL I 12 SHEET 3 AF9 4 ALA I 91 GLY I 98 -1 N TYR I 93 O THR I 113 SHEET 4 AF9 4 PHE I 106 TRP I 109 -1 O LEU I 108 N ARG I 97 SHEET 1 AG1 3 SER I 126 VAL I 127 0 SHEET 2 AG1 3 VAL I 148 TYR I 151 -1 O LYS I 149 N SER I 126 SHEET 3 AG1 3 TYR I 182 LEU I 184 -1 O TYR I 182 N TYR I 151 SHEET 1 AG2 3 ALA I 142 GLY I 145 0 SHEET 2 AG2 3 VAL I 187 VAL I 190 -1 O VAL I 188 N LEU I 144 SHEET 3 AG2 3 VAL I 169 HIS I 170 -1 N HIS I 170 O VAL I 187 SHEET 1 AG3 3 VAL I 158 SER I 159 0 SHEET 2 AG3 3 ILE I 201 VAL I 204 -1 O ASN I 203 N SER I 159 SHEET 3 AG3 3 VAL I 213 ARG I 216 -1 O VAL I 213 N VAL I 204 SHEET 1 AG4 4 MET M 4 THR M 5 0 SHEET 2 AG4 4 VAL M 19 ALA M 25 -1 O ARG M 24 N THR M 5 SHEET 3 AG4 4 ASP M 70 ILE M 75 -1 O LEU M 73 N ILE M 21 SHEET 4 AG4 4 PHE M 62 SER M 67 -1 N SER M 65 O THR M 72 SHEET 1 AG5 6 SER M 10 ALA M 13 0 SHEET 2 AG5 6 THR M 103 ILE M 107 1 O ARG M 104 N LEU M 11 SHEET 3 AG5 6 THR M 85 GLN M 90 -1 N TYR M 86 O THR M 103 SHEET 4 AG5 6 LEU M 33 GLN M 38 -1 N GLN M 38 O THR M 85 SHEET 5 AG5 6 LYS M 45 TYR M 49 -1 O LYS M 45 N GLN M 37 SHEET 6 AG5 6 SER M 53 LEU M 54 -1 O SER M 53 N TYR M 49 SHEET 1 AG6 4 SER M 115 PHE M 119 0 SHEET 2 AG6 4 THR M 130 PHE M 140 -1 O LEU M 136 N PHE M 117 SHEET 3 AG6 4 TYR M 174 LYS M 184 -1 O SER M 178 N CYS M 135 SHEET 4 AG6 4 SER M 163 VAL M 164 -1 N SER M 163 O SER M 177 SHEET 1 AG7 2 GLN M 148 VAL M 151 0 SHEET 2 AG7 2 TYR M 193 GLU M 196 -1 O ALA M 194 N LYS M 150 SHEET 1 AG8 4 GLN J 3 SER J 7 0 SHEET 2 AG8 4 LEU J 18 SER J 25 -1 O ALA J 23 N ALA J 5 SHEET 3 AG8 4 ALA J 77 ILE J 82 -1 O ILE J 82 N LEU J 18 SHEET 4 AG8 4 PHE J 67 ARG J 71 -1 N THR J 68 O GLN J 81 SHEET 1 AG9 6 LEU J 11 VAL J 12 0 SHEET 2 AG9 6 THR J 113 VAL J 117 1 O THR J 116 N VAL J 12 SHEET 3 AG9 6 ALA J 91 GLY J 98 -1 N TYR J 93 O THR J 113 SHEET 4 AG9 6 ASP J 33 GLN J 39 -1 N ASP J 33 O GLY J 98 SHEET 5 AG9 6 LEU J 45 ILE J 51 -1 O SER J 49 N TRP J 36 SHEET 6 AG9 6 THR J 57 TYR J 59 -1 O TYR J 58 N THR J 50 SHEET 1 AH1 4 LEU J 11 VAL J 12 0 SHEET 2 AH1 4 THR J 113 VAL J 117 1 O THR J 116 N VAL J 12 SHEET 3 AH1 4 ALA J 91 GLY J 98 -1 N TYR J 93 O THR J 113 SHEET 4 AH1 4 PHE J 106 TRP J 109 -1 O LEU J 108 N ARG J 97 SHEET 1 AH2 3 ALA J 142 LEU J 147 0 SHEET 2 AH2 3 TYR J 182 VAL J 190 -1 O VAL J 188 N LEU J 144 SHEET 3 AH2 3 VAL J 169 LEU J 176 -1 N PHE J 172 O SER J 185 SHEET 1 AH3 3 SER J 159 TRP J 160 0 SHEET 2 AH3 3 ILE J 201 HIS J 206 -1 O ASN J 203 N SER J 159 SHEET 3 AH3 3 THR J 211 ARG J 216 -1 O VAL J 213 N VAL J 204 SHEET 1 AH4 4 MET N 4 GLN N 6 0 SHEET 2 AH4 4 VAL N 19 ALA N 25 -1 O ARG N 24 N THR N 5 SHEET 3 AH4 4 ASP N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 4 AH4 4 PHE N 62 SER N 67 -1 N SER N 65 O THR N 72 SHEET 1 AH5 6 SER N 10 ALA N 13 0 SHEET 2 AH5 6 THR N 103 ILE N 107 1 O ARG N 104 N LEU N 11 SHEET 3 AH5 6 THR N 85 GLN N 90 -1 N TYR N 86 O THR N 103 SHEET 4 AH5 6 LEU N 33 GLN N 38 -1 N GLN N 38 O THR N 85 SHEET 5 AH5 6 LYS N 45 TYR N 49 -1 O LYS N 45 N GLN N 37 SHEET 6 AH5 6 SER N 53 LEU N 54 -1 O SER N 53 N TYR N 49 SHEET 1 AH6 4 SER N 115 PHE N 117 0 SHEET 2 AH6 4 SER N 132 PHE N 140 -1 O ASN N 138 N SER N 115 SHEET 3 AH6 4 TYR N 174 THR N 181 -1 O TYR N 174 N PHE N 140 SHEET 4 AH6 4 SER N 163 VAL N 164 -1 N SER N 163 O SER N 177 SHEET 1 AH7 3 LYS N 146 VAL N 151 0 SHEET 2 AH7 3 VAL N 192 THR N 198 -1 O GLU N 196 N GLN N 148 SHEET 3 AH7 3 SER N 209 ASN N 211 -1 O PHE N 210 N TYR N 193 SSBOND 1 CYS H 22 CYS H 95 1555 1555 2.03 SSBOND 2 CYS H 146 CYS H 202 1555 1555 2.03 SSBOND 3 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 4 CYS L 135 CYS L 195 1555 1555 2.03 SSBOND 5 CYS C 15 CYS C 136 1555 1555 2.03 SSBOND 6 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 7 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 8 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 9 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 10 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 11 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 12 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 13 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 14 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 15 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 16 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 17 CYS C 1032 CYS C 1043 1555 1555 2.03 SSBOND 18 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 19 CYS B 15 CYS B 136 1555 1555 2.03 SSBOND 20 CYS B 131 CYS B 166 1555 1555 2.03 SSBOND 21 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 22 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 23 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 24 CYS B 391 CYS B 525 1555 1555 2.03 SSBOND 25 CYS B 480 CYS B 488 1555 1555 2.03 SSBOND 26 CYS B 538 CYS B 590 1555 1555 2.03 SSBOND 27 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 28 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 29 CYS B 738 CYS B 760 1555 1555 2.03 SSBOND 30 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 31 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 32 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 33 CYS A 15 CYS A 136 1555 1555 2.03 SSBOND 34 CYS A 131 CYS A 166 1555 1555 2.03 SSBOND 35 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 36 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 37 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 38 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 39 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 40 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 41 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 42 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 43 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 44 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 45 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 46 CYS A 1082 CYS A 1126 1555 1555 2.03 SSBOND 47 CYS I 22 CYS I 95 1555 1555 2.03 SSBOND 48 CYS I 146 CYS I 202 1555 1555 2.03 SSBOND 49 CYS M 23 CYS M 88 1555 1555 2.03 SSBOND 50 CYS M 135 CYS M 195 1555 1555 2.03 SSBOND 51 CYS J 22 CYS J 95 1555 1555 2.03 SSBOND 52 CYS J 146 CYS J 202 1555 1555 2.03 SSBOND 53 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 54 CYS N 135 CYS N 195 1555 1555 2.03 LINK ND2 ASN C 61 C1 NAG D 1 1555 1555 1.44 LINK ND2 ASN C 122 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN C 165 C1 NAG F 1 1555 1555 1.44 LINK ND2 ASN C 282 C1 NAG C1301 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN C 657 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 709 C1 NAG O 1 1555 1555 1.45 LINK ND2 ASN C 717 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN C1074 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN B 61 C1 NAG B1301 1555 1555 1.44 LINK ND2 ASN B 122 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN B 165 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN B 234 C1 NAG B1302 1555 1555 1.44 LINK ND2 ASN B 282 C1 NAG B1303 1555 1555 1.44 LINK ND2 ASN B 331 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1304 1555 1555 1.44 LINK ND2 ASN B 709 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN B 717 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN B1074 C1 NAG B1305 1555 1555 1.44 LINK ND2 ASN B1098 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN A 61 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 122 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN A 165 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 282 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 709 C1 NAG e 1 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG g 1 1555 1555 1.44 LINK ND2 ASN A1074 C1 NAG A1305 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG h 1 1555 1555 1.45 LINK ND2 ASN A1134 C1 NAG i 1 1555 1555 1.44 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.46 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.44 LINK O4 NAG E 2 C1 BMA E 3 1555 1555 1.45 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.46 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG G 2 C1 BMA G 3 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.46 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.46 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG X 2 C1 BMA X 3 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.44 LINK O4 NAG Y 2 C1 BMA Y 3 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.46 LINK O4 NAG Z 2 C1 BMA Z 3 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.44 LINK O4 NAG b 2 C1 BMA b 3 1555 1555 1.44 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.44 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.45 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.44 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.45 LINK O4 NAG f 2 C1 BMA f 3 1555 1555 1.44 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.44 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.45 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000