HEADER VIRAL PROTEIN/IMMUNE SYSTEM 13-DEC-24 9L15 TITLE STRUCTURE OF SARS-COV-2 EG.5.1 VARIANT SPIKE PROTEIN COMPLEXED WITH TITLE 2 ANTIBODY XGI-203 COMPND MOL_ID: 1; COMPND 2 MOLECULE: XGI-203 HEAVY CHAIN; COMPND 3 CHAIN: H, I, J; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: XGI-203 LIGHT CHAIN; COMPND 7 CHAIN: L, M, N; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 11 CHAIN: C, B, A; COMPND 12 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 13 2; SOURCE 14 ORGANISM_TAXID: 2697049; SOURCE 15 STRAIN: OMICRON/EG.5.1; SOURCE 16 GENE: S, 2; SOURCE 17 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 18 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS SPIKE-ANTIBODY COMPLEX, VIRAL PROTEIN/IMMUNE SYSTEM, VIRAL PROTEIN- KEYWDS 2 IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR Y.N.QIU,L.SUN REVDAT 1 10-DEC-25 9L15 0 JRNL AUTH M.XIE,Y.QIU,X.ZHAO,J.SHI,Y.LIU,Q.ZHANG,J.HE,J.LI,L.LIU, JRNL AUTH 2 S.SUN,Y.ZHU,Q.MAO,Y.LONG,T.Y.OLIVEIRA,Z.WANG,Y.ZHOU,Y.YAN, JRNL AUTH 3 A.XIA,W.ZAI,C.T.MAYER,Y.XIE,S.JIANG,L.LU,R.XIA,F.WU,L.SUN, JRNL AUTH 4 P.WANG,H.CHU,Q.WANG JRNL TITL ORPHAN BROADLY RBD-BINDING ANTIBODIES ANNOTATE THREE JRNL TITL 2 REMAINING CONSERVED RBD EPITOPES ALONG SARS-COV-2 EVOLUTION. JRNL REF NAT COMMUN V. 16 10566 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 41298374 JRNL DOI 10.1038/S41467-025-65596-0 REMARK 2 REMARK 2 RESOLUTION. 2.95 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.950 REMARK 3 NUMBER OF PARTICLES : 32232 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9L15 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 17-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1300054704. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : EG.5.1 SPIKE PROTEIN (S) IN REMARK 245 COMPLEX WITH ANTIBODY XGI-203; REMARK 245 XGI-203 HEAVY CHAIN; XGI-203 REMARK 245 LIGHT CHAIN; EG.5.1 SPIKE REMARK 245 GLYCOPROTEIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, I, M, J, N, C, B, A, D, REMARK 350 AND CHAINS: E, F, G, K, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER H 142 REMARK 465 SER H 143 REMARK 465 LYS H 144 REMARK 465 SER H 145 REMARK 465 THR H 146 REMARK 465 SER H 147 REMARK 465 VAL H 226 REMARK 465 GLU H 227 REMARK 465 PRO H 228 REMARK 465 LYS H 229 REMARK 465 SER H 230 REMARK 465 CYS H 231 REMARK 465 ASP H 232 REMARK 465 LYS H 233 REMARK 465 THR H 234 REMARK 465 HIS H 235 REMARK 465 THR H 236 REMARK 465 CYS H 237 REMARK 465 PRO H 238 REMARK 465 PRO H 239 REMARK 465 CYS H 240 REMARK 465 PRO H 241 REMARK 465 ALA H 242 REMARK 465 PRO H 243 REMARK 465 GLU H 244 REMARK 465 LEU H 245 REMARK 465 LEU H 246 REMARK 465 GLY H 247 REMARK 465 GLY H 248 REMARK 465 PRO H 249 REMARK 465 SER H 250 REMARK 465 VAL H 251 REMARK 465 PHE H 252 REMARK 465 LEU H 253 REMARK 465 PHE H 254 REMARK 465 PRO H 255 REMARK 465 PRO H 256 REMARK 465 LYS H 257 REMARK 465 PRO H 258 REMARK 465 LYS H 259 REMARK 465 ASP H 260 REMARK 465 THR H 261 REMARK 465 LEU H 262 REMARK 465 MET H 263 REMARK 465 ILE H 264 REMARK 465 SER H 265 REMARK 465 ARG H 266 REMARK 465 THR H 267 REMARK 465 PRO H 268 REMARK 465 GLU H 269 REMARK 465 VAL H 270 REMARK 465 THR H 271 REMARK 465 CYS H 272 REMARK 465 VAL H 273 REMARK 465 VAL H 274 REMARK 465 VAL H 275 REMARK 465 ASP H 276 REMARK 465 VAL H 277 REMARK 465 SER H 278 REMARK 465 HIS H 279 REMARK 465 GLU H 280 REMARK 465 ASP H 281 REMARK 465 PRO H 282 REMARK 465 GLU H 283 REMARK 465 VAL H 284 REMARK 465 LYS H 285 REMARK 465 PHE H 286 REMARK 465 ASN H 287 REMARK 465 TRP H 288 REMARK 465 TYR H 289 REMARK 465 VAL H 290 REMARK 465 ASP H 291 REMARK 465 GLY H 292 REMARK 465 VAL H 293 REMARK 465 GLU H 294 REMARK 465 VAL H 295 REMARK 465 HIS H 296 REMARK 465 ASN H 297 REMARK 465 ALA H 298 REMARK 465 LYS H 299 REMARK 465 THR H 300 REMARK 465 LYS H 301 REMARK 465 PRO H 302 REMARK 465 ARG H 303 REMARK 465 GLU H 304 REMARK 465 GLU H 305 REMARK 465 GLN H 306 REMARK 465 TYR H 307 REMARK 465 ASN H 308 REMARK 465 SER H 309 REMARK 465 THR H 310 REMARK 465 TYR H 311 REMARK 465 ARG H 312 REMARK 465 VAL H 313 REMARK 465 VAL H 314 REMARK 465 SER H 315 REMARK 465 VAL H 316 REMARK 465 LEU H 317 REMARK 465 THR H 318 REMARK 465 VAL H 319 REMARK 465 LEU H 320 REMARK 465 HIS H 321 REMARK 465 GLN H 322 REMARK 465 ASP H 323 REMARK 465 TRP H 324 REMARK 465 LEU H 325 REMARK 465 ASN H 326 REMARK 465 GLY H 327 REMARK 465 LYS H 328 REMARK 465 GLU H 329 REMARK 465 TYR H 330 REMARK 465 LYS H 331 REMARK 465 CYS H 332 REMARK 465 LYS H 333 REMARK 465 VAL H 334 REMARK 465 SER H 335 REMARK 465 ASN H 336 REMARK 465 LYS H 337 REMARK 465 ALA H 338 REMARK 465 LEU H 339 REMARK 465 PRO H 340 REMARK 465 ALA H 341 REMARK 465 PRO H 342 REMARK 465 ILE H 343 REMARK 465 GLU H 344 REMARK 465 LYS H 345 REMARK 465 THR H 346 REMARK 465 ILE H 347 REMARK 465 SER H 348 REMARK 465 LYS H 349 REMARK 465 ALA H 350 REMARK 465 LYS H 351 REMARK 465 GLY H 352 REMARK 465 GLN H 353 REMARK 465 PRO H 354 REMARK 465 ARG H 355 REMARK 465 GLU H 356 REMARK 465 PRO H 357 REMARK 465 GLN H 358 REMARK 465 VAL H 359 REMARK 465 TYR H 360 REMARK 465 THR H 361 REMARK 465 LEU H 362 REMARK 465 PRO H 363 REMARK 465 PRO H 364 REMARK 465 SER H 365 REMARK 465 ARG H 366 REMARK 465 GLU H 367 REMARK 465 GLU H 368 REMARK 465 MET H 369 REMARK 465 THR H 370 REMARK 465 LYS H 371 REMARK 465 ASN H 372 REMARK 465 GLN H 373 REMARK 465 VAL H 374 REMARK 465 SER H 375 REMARK 465 LEU H 376 REMARK 465 THR H 377 REMARK 465 CYS H 378 REMARK 465 LEU H 379 REMARK 465 VAL H 380 REMARK 465 LYS H 381 REMARK 465 GLY H 382 REMARK 465 PHE H 383 REMARK 465 TYR H 384 REMARK 465 PRO H 385 REMARK 465 SER H 386 REMARK 465 ASP H 387 REMARK 465 ILE H 388 REMARK 465 ALA H 389 REMARK 465 VAL H 390 REMARK 465 GLU H 391 REMARK 465 TRP H 392 REMARK 465 GLU H 393 REMARK 465 SER H 394 REMARK 465 ASN H 395 REMARK 465 GLY H 396 REMARK 465 GLN H 397 REMARK 465 PRO H 398 REMARK 465 GLU H 399 REMARK 465 ASN H 400 REMARK 465 ASN H 401 REMARK 465 TYR H 402 REMARK 465 LYS H 403 REMARK 465 THR H 404 REMARK 465 THR H 405 REMARK 465 PRO H 406 REMARK 465 PRO H 407 REMARK 465 VAL H 408 REMARK 465 LEU H 409 REMARK 465 ASP H 410 REMARK 465 SER H 411 REMARK 465 ASP H 412 REMARK 465 GLY H 413 REMARK 465 SER H 414 REMARK 465 PHE H 415 REMARK 465 PHE H 416 REMARK 465 LEU H 417 REMARK 465 TYR H 418 REMARK 465 SER H 419 REMARK 465 LYS H 420 REMARK 465 LEU H 421 REMARK 465 THR H 422 REMARK 465 VAL H 423 REMARK 465 ASP H 424 REMARK 465 LYS H 425 REMARK 465 SER H 426 REMARK 465 ARG H 427 REMARK 465 TRP H 428 REMARK 465 GLN H 429 REMARK 465 GLN H 430 REMARK 465 GLY H 431 REMARK 465 ASN H 432 REMARK 465 VAL H 433 REMARK 465 PHE H 434 REMARK 465 SER H 435 REMARK 465 CYS H 436 REMARK 465 SER H 437 REMARK 465 VAL H 438 REMARK 465 MET H 439 REMARK 465 HIS H 440 REMARK 465 GLU H 441 REMARK 465 ALA H 442 REMARK 465 LEU H 443 REMARK 465 HIS H 444 REMARK 465 ASN H 445 REMARK 465 HIS H 446 REMARK 465 TYR H 447 REMARK 465 THR H 448 REMARK 465 GLN H 449 REMARK 465 LYS H 450 REMARK 465 SER H 451 REMARK 465 LEU H 452 REMARK 465 SER H 453 REMARK 465 LEU H 454 REMARK 465 SER H 455 REMARK 465 PRO H 456 REMARK 465 GLY H 457 REMARK 465 LYS H 458 REMARK 465 CYS L 232 REMARK 465 SER L 233 REMARK 465 SER I 142 REMARK 465 SER I 143 REMARK 465 LYS I 144 REMARK 465 SER I 145 REMARK 465 THR I 146 REMARK 465 SER I 147 REMARK 465 VAL I 226 REMARK 465 GLU I 227 REMARK 465 PRO I 228 REMARK 465 LYS I 229 REMARK 465 SER I 230 REMARK 465 CYS I 231 REMARK 465 ASP I 232 REMARK 465 LYS I 233 REMARK 465 THR I 234 REMARK 465 HIS I 235 REMARK 465 THR I 236 REMARK 465 CYS I 237 REMARK 465 PRO I 238 REMARK 465 PRO I 239 REMARK 465 CYS I 240 REMARK 465 PRO I 241 REMARK 465 ALA I 242 REMARK 465 PRO I 243 REMARK 465 GLU I 244 REMARK 465 LEU I 245 REMARK 465 LEU I 246 REMARK 465 GLY I 247 REMARK 465 GLY I 248 REMARK 465 PRO I 249 REMARK 465 SER I 250 REMARK 465 VAL I 251 REMARK 465 PHE I 252 REMARK 465 LEU I 253 REMARK 465 PHE I 254 REMARK 465 PRO I 255 REMARK 465 PRO I 256 REMARK 465 LYS I 257 REMARK 465 PRO I 258 REMARK 465 LYS I 259 REMARK 465 ASP I 260 REMARK 465 THR I 261 REMARK 465 LEU I 262 REMARK 465 MET I 263 REMARK 465 ILE I 264 REMARK 465 SER I 265 REMARK 465 ARG I 266 REMARK 465 THR I 267 REMARK 465 PRO I 268 REMARK 465 GLU I 269 REMARK 465 VAL I 270 REMARK 465 THR I 271 REMARK 465 CYS I 272 REMARK 465 VAL I 273 REMARK 465 VAL I 274 REMARK 465 VAL I 275 REMARK 465 ASP I 276 REMARK 465 VAL I 277 REMARK 465 SER I 278 REMARK 465 HIS I 279 REMARK 465 GLU I 280 REMARK 465 ASP I 281 REMARK 465 PRO I 282 REMARK 465 GLU I 283 REMARK 465 VAL I 284 REMARK 465 LYS I 285 REMARK 465 PHE I 286 REMARK 465 ASN I 287 REMARK 465 TRP I 288 REMARK 465 TYR I 289 REMARK 465 VAL I 290 REMARK 465 ASP I 291 REMARK 465 GLY I 292 REMARK 465 VAL I 293 REMARK 465 GLU I 294 REMARK 465 VAL I 295 REMARK 465 HIS I 296 REMARK 465 ASN I 297 REMARK 465 ALA I 298 REMARK 465 LYS I 299 REMARK 465 THR I 300 REMARK 465 LYS I 301 REMARK 465 PRO I 302 REMARK 465 ARG I 303 REMARK 465 GLU I 304 REMARK 465 GLU I 305 REMARK 465 GLN I 306 REMARK 465 TYR I 307 REMARK 465 ASN I 308 REMARK 465 SER I 309 REMARK 465 THR I 310 REMARK 465 TYR I 311 REMARK 465 ARG I 312 REMARK 465 VAL I 313 REMARK 465 VAL I 314 REMARK 465 SER I 315 REMARK 465 VAL I 316 REMARK 465 LEU I 317 REMARK 465 THR I 318 REMARK 465 VAL I 319 REMARK 465 LEU I 320 REMARK 465 HIS I 321 REMARK 465 GLN I 322 REMARK 465 ASP I 323 REMARK 465 TRP I 324 REMARK 465 LEU I 325 REMARK 465 ASN I 326 REMARK 465 GLY I 327 REMARK 465 LYS I 328 REMARK 465 GLU I 329 REMARK 465 TYR I 330 REMARK 465 LYS I 331 REMARK 465 CYS I 332 REMARK 465 LYS I 333 REMARK 465 VAL I 334 REMARK 465 SER I 335 REMARK 465 ASN I 336 REMARK 465 LYS I 337 REMARK 465 ALA I 338 REMARK 465 LEU I 339 REMARK 465 PRO I 340 REMARK 465 ALA I 341 REMARK 465 PRO I 342 REMARK 465 ILE I 343 REMARK 465 GLU I 344 REMARK 465 LYS I 345 REMARK 465 THR I 346 REMARK 465 ILE I 347 REMARK 465 SER I 348 REMARK 465 LYS I 349 REMARK 465 ALA I 350 REMARK 465 LYS I 351 REMARK 465 GLY I 352 REMARK 465 GLN I 353 REMARK 465 PRO I 354 REMARK 465 ARG I 355 REMARK 465 GLU I 356 REMARK 465 PRO I 357 REMARK 465 GLN I 358 REMARK 465 VAL I 359 REMARK 465 TYR I 360 REMARK 465 THR I 361 REMARK 465 LEU I 362 REMARK 465 PRO I 363 REMARK 465 PRO I 364 REMARK 465 SER I 365 REMARK 465 ARG I 366 REMARK 465 GLU I 367 REMARK 465 GLU I 368 REMARK 465 MET I 369 REMARK 465 THR I 370 REMARK 465 LYS I 371 REMARK 465 ASN I 372 REMARK 465 GLN I 373 REMARK 465 VAL I 374 REMARK 465 SER I 375 REMARK 465 LEU I 376 REMARK 465 THR I 377 REMARK 465 CYS I 378 REMARK 465 LEU I 379 REMARK 465 VAL I 380 REMARK 465 LYS I 381 REMARK 465 GLY I 382 REMARK 465 PHE I 383 REMARK 465 TYR I 384 REMARK 465 PRO I 385 REMARK 465 SER I 386 REMARK 465 ASP I 387 REMARK 465 ILE I 388 REMARK 465 ALA I 389 REMARK 465 VAL I 390 REMARK 465 GLU I 391 REMARK 465 TRP I 392 REMARK 465 GLU I 393 REMARK 465 SER I 394 REMARK 465 ASN I 395 REMARK 465 GLY I 396 REMARK 465 GLN I 397 REMARK 465 PRO I 398 REMARK 465 GLU I 399 REMARK 465 ASN I 400 REMARK 465 ASN I 401 REMARK 465 TYR I 402 REMARK 465 LYS I 403 REMARK 465 THR I 404 REMARK 465 THR I 405 REMARK 465 PRO I 406 REMARK 465 PRO I 407 REMARK 465 VAL I 408 REMARK 465 LEU I 409 REMARK 465 ASP I 410 REMARK 465 SER I 411 REMARK 465 ASP I 412 REMARK 465 GLY I 413 REMARK 465 SER I 414 REMARK 465 PHE I 415 REMARK 465 PHE I 416 REMARK 465 LEU I 417 REMARK 465 TYR I 418 REMARK 465 SER I 419 REMARK 465 LYS I 420 REMARK 465 LEU I 421 REMARK 465 THR I 422 REMARK 465 VAL I 423 REMARK 465 ASP I 424 REMARK 465 LYS I 425 REMARK 465 SER I 426 REMARK 465 ARG I 427 REMARK 465 TRP I 428 REMARK 465 GLN I 429 REMARK 465 GLN I 430 REMARK 465 GLY I 431 REMARK 465 ASN I 432 REMARK 465 VAL I 433 REMARK 465 PHE I 434 REMARK 465 SER I 435 REMARK 465 CYS I 436 REMARK 465 SER I 437 REMARK 465 VAL I 438 REMARK 465 MET I 439 REMARK 465 HIS I 440 REMARK 465 GLU I 441 REMARK 465 ALA I 442 REMARK 465 LEU I 443 REMARK 465 HIS I 444 REMARK 465 ASN I 445 REMARK 465 HIS I 446 REMARK 465 TYR I 447 REMARK 465 THR I 448 REMARK 465 GLN I 449 REMARK 465 LYS I 450 REMARK 465 SER I 451 REMARK 465 LEU I 452 REMARK 465 SER I 453 REMARK 465 LEU I 454 REMARK 465 SER I 455 REMARK 465 PRO I 456 REMARK 465 GLY I 457 REMARK 465 LYS I 458 REMARK 465 CYS M 232 REMARK 465 SER M 233 REMARK 465 SER J 142 REMARK 465 SER J 143 REMARK 465 LYS J 144 REMARK 465 SER J 145 REMARK 465 THR J 146 REMARK 465 SER J 147 REMARK 465 VAL J 226 REMARK 465 GLU J 227 REMARK 465 PRO J 228 REMARK 465 LYS J 229 REMARK 465 SER J 230 REMARK 465 CYS J 231 REMARK 465 ASP J 232 REMARK 465 LYS J 233 REMARK 465 THR J 234 REMARK 465 HIS J 235 REMARK 465 THR J 236 REMARK 465 CYS J 237 REMARK 465 PRO J 238 REMARK 465 PRO J 239 REMARK 465 CYS J 240 REMARK 465 PRO J 241 REMARK 465 ALA J 242 REMARK 465 PRO J 243 REMARK 465 GLU J 244 REMARK 465 LEU J 245 REMARK 465 LEU J 246 REMARK 465 GLY J 247 REMARK 465 GLY J 248 REMARK 465 PRO J 249 REMARK 465 SER J 250 REMARK 465 VAL J 251 REMARK 465 PHE J 252 REMARK 465 LEU J 253 REMARK 465 PHE J 254 REMARK 465 PRO J 255 REMARK 465 PRO J 256 REMARK 465 LYS J 257 REMARK 465 PRO J 258 REMARK 465 LYS J 259 REMARK 465 ASP J 260 REMARK 465 THR J 261 REMARK 465 LEU J 262 REMARK 465 MET J 263 REMARK 465 ILE J 264 REMARK 465 SER J 265 REMARK 465 ARG J 266 REMARK 465 THR J 267 REMARK 465 PRO J 268 REMARK 465 GLU J 269 REMARK 465 VAL J 270 REMARK 465 THR J 271 REMARK 465 CYS J 272 REMARK 465 VAL J 273 REMARK 465 VAL J 274 REMARK 465 VAL J 275 REMARK 465 ASP J 276 REMARK 465 VAL J 277 REMARK 465 SER J 278 REMARK 465 HIS J 279 REMARK 465 GLU J 280 REMARK 465 ASP J 281 REMARK 465 PRO J 282 REMARK 465 GLU J 283 REMARK 465 VAL J 284 REMARK 465 LYS J 285 REMARK 465 PHE J 286 REMARK 465 ASN J 287 REMARK 465 TRP J 288 REMARK 465 TYR J 289 REMARK 465 VAL J 290 REMARK 465 ASP J 291 REMARK 465 GLY J 292 REMARK 465 VAL J 293 REMARK 465 GLU J 294 REMARK 465 VAL J 295 REMARK 465 HIS J 296 REMARK 465 ASN J 297 REMARK 465 ALA J 298 REMARK 465 LYS J 299 REMARK 465 THR J 300 REMARK 465 LYS J 301 REMARK 465 PRO J 302 REMARK 465 ARG J 303 REMARK 465 GLU J 304 REMARK 465 GLU J 305 REMARK 465 GLN J 306 REMARK 465 TYR J 307 REMARK 465 ASN J 308 REMARK 465 SER J 309 REMARK 465 THR J 310 REMARK 465 TYR J 311 REMARK 465 ARG J 312 REMARK 465 VAL J 313 REMARK 465 VAL J 314 REMARK 465 SER J 315 REMARK 465 VAL J 316 REMARK 465 LEU J 317 REMARK 465 THR J 318 REMARK 465 VAL J 319 REMARK 465 LEU J 320 REMARK 465 HIS J 321 REMARK 465 GLN J 322 REMARK 465 ASP J 323 REMARK 465 TRP J 324 REMARK 465 LEU J 325 REMARK 465 ASN J 326 REMARK 465 GLY J 327 REMARK 465 LYS J 328 REMARK 465 GLU J 329 REMARK 465 TYR J 330 REMARK 465 LYS J 331 REMARK 465 CYS J 332 REMARK 465 LYS J 333 REMARK 465 VAL J 334 REMARK 465 SER J 335 REMARK 465 ASN J 336 REMARK 465 LYS J 337 REMARK 465 ALA J 338 REMARK 465 LEU J 339 REMARK 465 PRO J 340 REMARK 465 ALA J 341 REMARK 465 PRO J 342 REMARK 465 ILE J 343 REMARK 465 GLU J 344 REMARK 465 LYS J 345 REMARK 465 THR J 346 REMARK 465 ILE J 347 REMARK 465 SER J 348 REMARK 465 LYS J 349 REMARK 465 ALA J 350 REMARK 465 LYS J 351 REMARK 465 GLY J 352 REMARK 465 GLN J 353 REMARK 465 PRO J 354 REMARK 465 ARG J 355 REMARK 465 GLU J 356 REMARK 465 PRO J 357 REMARK 465 GLN J 358 REMARK 465 VAL J 359 REMARK 465 TYR J 360 REMARK 465 THR J 361 REMARK 465 LEU J 362 REMARK 465 PRO J 363 REMARK 465 PRO J 364 REMARK 465 SER J 365 REMARK 465 ARG J 366 REMARK 465 GLU J 367 REMARK 465 GLU J 368 REMARK 465 MET J 369 REMARK 465 THR J 370 REMARK 465 LYS J 371 REMARK 465 ASN J 372 REMARK 465 GLN J 373 REMARK 465 VAL J 374 REMARK 465 SER J 375 REMARK 465 LEU J 376 REMARK 465 THR J 377 REMARK 465 CYS J 378 REMARK 465 LEU J 379 REMARK 465 VAL J 380 REMARK 465 LYS J 381 REMARK 465 GLY J 382 REMARK 465 PHE J 383 REMARK 465 TYR J 384 REMARK 465 PRO J 385 REMARK 465 SER J 386 REMARK 465 ASP J 387 REMARK 465 ILE J 388 REMARK 465 ALA J 389 REMARK 465 VAL J 390 REMARK 465 GLU J 391 REMARK 465 TRP J 392 REMARK 465 GLU J 393 REMARK 465 SER J 394 REMARK 465 ASN J 395 REMARK 465 GLY J 396 REMARK 465 GLN J 397 REMARK 465 PRO J 398 REMARK 465 GLU J 399 REMARK 465 ASN J 400 REMARK 465 ASN J 401 REMARK 465 TYR J 402 REMARK 465 LYS J 403 REMARK 465 THR J 404 REMARK 465 THR J 405 REMARK 465 PRO J 406 REMARK 465 PRO J 407 REMARK 465 VAL J 408 REMARK 465 LEU J 409 REMARK 465 ASP J 410 REMARK 465 SER J 411 REMARK 465 ASP J 412 REMARK 465 GLY J 413 REMARK 465 SER J 414 REMARK 465 PHE J 415 REMARK 465 PHE J 416 REMARK 465 LEU J 417 REMARK 465 TYR J 418 REMARK 465 SER J 419 REMARK 465 LYS J 420 REMARK 465 LEU J 421 REMARK 465 THR J 422 REMARK 465 VAL J 423 REMARK 465 ASP J 424 REMARK 465 LYS J 425 REMARK 465 SER J 426 REMARK 465 ARG J 427 REMARK 465 TRP J 428 REMARK 465 GLN J 429 REMARK 465 GLN J 430 REMARK 465 GLY J 431 REMARK 465 ASN J 432 REMARK 465 VAL J 433 REMARK 465 PHE J 434 REMARK 465 SER J 435 REMARK 465 CYS J 436 REMARK 465 SER J 437 REMARK 465 VAL J 438 REMARK 465 MET J 439 REMARK 465 HIS J 440 REMARK 465 GLU J 441 REMARK 465 ALA J 442 REMARK 465 LEU J 443 REMARK 465 HIS J 444 REMARK 465 ASN J 445 REMARK 465 HIS J 446 REMARK 465 TYR J 447 REMARK 465 THR J 448 REMARK 465 GLN J 449 REMARK 465 LYS J 450 REMARK 465 SER J 451 REMARK 465 LEU J 452 REMARK 465 SER J 453 REMARK 465 LEU J 454 REMARK 465 SER J 455 REMARK 465 PRO J 456 REMARK 465 GLY J 457 REMARK 465 LYS J 458 REMARK 465 CYS N 232 REMARK 465 SER N 233 REMARK 465 MET C -10 REMARK 465 PRO C -9 REMARK 465 MET C -8 REMARK 465 GLY C -7 REMARK 465 SER C -6 REMARK 465 LEU C -5 REMARK 465 GLN C -4 REMARK 465 PRO C -3 REMARK 465 LEU C -2 REMARK 465 ALA C -1 REMARK 465 THR C 0 REMARK 465 LEU C 1 REMARK 465 TYR C 2 REMARK 465 LEU C 3 REMARK 465 LEU C 4 REMARK 465 GLY C 5 REMARK 465 MET C 6 REMARK 465 LEU C 7 REMARK 465 VAL C 8 REMARK 465 ALA C 9 REMARK 465 SER C 10 REMARK 465 VAL C 11 REMARK 465 LEU C 12 REMARK 465 ALA C 13 REMARK 465 HIS C 69 REMARK 465 VAL C 70 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 76 REMARK 465 LYS C 77 REMARK 465 ARG C 78 REMARK 465 PHE C 79 REMARK 465 GLN C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 PHE C 175 REMARK 465 LEU C 176 REMARK 465 MET C 177 REMARK 465 ASP C 178 REMARK 465 LEU C 179 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLU C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 PHE C 186 REMARK 465 LYS C 187 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 VAL C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 GLY C 261 REMARK 465 ALA C 262 REMARK 465 ALA C 263 REMARK 465 PRO C 621 REMARK 465 VAL C 622 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 THR C 638 REMARK 465 GLY C 639 REMARK 465 GLN C 677 REMARK 465 THR C 678 REMARK 465 LYS C 679 REMARK 465 SER C 680 REMARK 465 HIS C 681 REMARK 465 GLY C 682 REMARK 465 SER C 683 REMARK 465 ALA C 684 REMARK 465 SER C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 SER C 689 REMARK 465 THR C 827 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 CYS C 851 REMARK 465 ALA C 852 REMARK 465 GLN C 853 REMARK 465 LEU C 1145 REMARK 465 ASP C 1146 REMARK 465 SER C 1147 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 GLY C 1209 REMARK 465 SER C 1210 REMARK 465 GLY C 1211 REMARK 465 TYR C 1212 REMARK 465 ILE C 1213 REMARK 465 PRO C 1214 REMARK 465 GLU C 1215 REMARK 465 ALA C 1216 REMARK 465 PRO C 1217 REMARK 465 ARG C 1218 REMARK 465 ASP C 1219 REMARK 465 GLY C 1220 REMARK 465 GLN C 1221 REMARK 465 ALA C 1222 REMARK 465 TYR C 1223 REMARK 465 VAL C 1224 REMARK 465 ARG C 1225 REMARK 465 LYS C 1226 REMARK 465 ASP C 1227 REMARK 465 GLY C 1228 REMARK 465 GLU C 1229 REMARK 465 TRP C 1230 REMARK 465 VAL C 1231 REMARK 465 PHE C 1232 REMARK 465 LEU C 1233 REMARK 465 SER C 1234 REMARK 465 THR C 1235 REMARK 465 PHE C 1236 REMARK 465 LEU C 1237 REMARK 465 SER C 1238 REMARK 465 GLY C 1239 REMARK 465 LEU C 1240 REMARK 465 GLU C 1241 REMARK 465 VAL C 1242 REMARK 465 LEU C 1243 REMARK 465 PHE C 1244 REMARK 465 GLN C 1245 REMARK 465 GLY C 1246 REMARK 465 PRO C 1247 REMARK 465 GLY C 1248 REMARK 465 GLY C 1249 REMARK 465 TRP C 1250 REMARK 465 SER C 1251 REMARK 465 HIS C 1252 REMARK 465 PRO C 1253 REMARK 465 GLN C 1254 REMARK 465 PHE C 1255 REMARK 465 GLU C 1256 REMARK 465 LYS C 1257 REMARK 465 GLY C 1258 REMARK 465 GLY C 1259 REMARK 465 GLY C 1260 REMARK 465 SER C 1261 REMARK 465 GLY C 1262 REMARK 465 GLY C 1263 REMARK 465 GLY C 1264 REMARK 465 SER C 1265 REMARK 465 GLY C 1266 REMARK 465 GLY C 1267 REMARK 465 SER C 1268 REMARK 465 ALA C 1269 REMARK 465 TRP C 1270 REMARK 465 SER C 1271 REMARK 465 HIS C 1272 REMARK 465 PRO C 1273 REMARK 465 GLN C 1274 REMARK 465 PHE C 1275 REMARK 465 GLU C 1276 REMARK 465 LYS C 1277 REMARK 465 GLY C 1278 REMARK 465 GLY C 1279 REMARK 465 SER C 1280 REMARK 465 HIS C 1281 REMARK 465 HIS C 1282 REMARK 465 HIS C 1283 REMARK 465 HIS C 1284 REMARK 465 HIS C 1285 REMARK 465 HIS C 1286 REMARK 465 HIS C 1287 REMARK 465 HIS C 1288 REMARK 465 MET B -10 REMARK 465 PRO B -9 REMARK 465 MET B -8 REMARK 465 GLY B -7 REMARK 465 SER B -6 REMARK 465 LEU B -5 REMARK 465 GLN B -4 REMARK 465 PRO B -3 REMARK 465 LEU B -2 REMARK 465 ALA B -1 REMARK 465 THR B 0 REMARK 465 LEU B 1 REMARK 465 TYR B 2 REMARK 465 LEU B 3 REMARK 465 LEU B 4 REMARK 465 GLY B 5 REMARK 465 MET B 6 REMARK 465 LEU B 7 REMARK 465 VAL B 8 REMARK 465 ALA B 9 REMARK 465 SER B 10 REMARK 465 VAL B 11 REMARK 465 LEU B 12 REMARK 465 ALA B 13 REMARK 465 ILE B 68 REMARK 465 HIS B 69 REMARK 465 VAL B 70 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 THR B 76 REMARK 465 LYS B 77 REMARK 465 TYR B 145 REMARK 465 GLN B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASN B 149 REMARK 465 LYS B 150 REMARK 465 SER B 151 REMARK 465 TRP B 152 REMARK 465 PHE B 175 REMARK 465 LEU B 176 REMARK 465 MET B 177 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLU B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 PHE B 186 REMARK 465 LYS B 187 REMARK 465 ARG B 246 REMARK 465 SER B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 VAL B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 SER B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 TRP B 258 REMARK 465 THR B 259 REMARK 465 ALA B 260 REMARK 465 GLY B 261 REMARK 465 VAL B 622 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 TYR B 636 REMARK 465 SER B 637 REMARK 465 THR B 638 REMARK 465 GLY B 639 REMARK 465 GLN B 677 REMARK 465 THR B 678 REMARK 465 LYS B 679 REMARK 465 SER B 680 REMARK 465 HIS B 681 REMARK 465 GLY B 682 REMARK 465 SER B 683 REMARK 465 ALA B 684 REMARK 465 SER B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 SER B 689 REMARK 465 THR B 827 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 CYS B 851 REMARK 465 ALA B 852 REMARK 465 GLN B 853 REMARK 465 LEU B 1145 REMARK 465 ASP B 1146 REMARK 465 SER B 1147 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 GLY B 1209 REMARK 465 SER B 1210 REMARK 465 GLY B 1211 REMARK 465 TYR B 1212 REMARK 465 ILE B 1213 REMARK 465 PRO B 1214 REMARK 465 GLU B 1215 REMARK 465 ALA B 1216 REMARK 465 PRO B 1217 REMARK 465 ARG B 1218 REMARK 465 ASP B 1219 REMARK 465 GLY B 1220 REMARK 465 GLN B 1221 REMARK 465 ALA B 1222 REMARK 465 TYR B 1223 REMARK 465 VAL B 1224 REMARK 465 ARG B 1225 REMARK 465 LYS B 1226 REMARK 465 ASP B 1227 REMARK 465 GLY B 1228 REMARK 465 GLU B 1229 REMARK 465 TRP B 1230 REMARK 465 VAL B 1231 REMARK 465 PHE B 1232 REMARK 465 LEU B 1233 REMARK 465 SER B 1234 REMARK 465 THR B 1235 REMARK 465 PHE B 1236 REMARK 465 LEU B 1237 REMARK 465 SER B 1238 REMARK 465 GLY B 1239 REMARK 465 LEU B 1240 REMARK 465 GLU B 1241 REMARK 465 VAL B 1242 REMARK 465 LEU B 1243 REMARK 465 PHE B 1244 REMARK 465 GLN B 1245 REMARK 465 GLY B 1246 REMARK 465 PRO B 1247 REMARK 465 GLY B 1248 REMARK 465 GLY B 1249 REMARK 465 TRP B 1250 REMARK 465 SER B 1251 REMARK 465 HIS B 1252 REMARK 465 PRO B 1253 REMARK 465 GLN B 1254 REMARK 465 PHE B 1255 REMARK 465 GLU B 1256 REMARK 465 LYS B 1257 REMARK 465 GLY B 1258 REMARK 465 GLY B 1259 REMARK 465 GLY B 1260 REMARK 465 SER B 1261 REMARK 465 GLY B 1262 REMARK 465 GLY B 1263 REMARK 465 GLY B 1264 REMARK 465 SER B 1265 REMARK 465 GLY B 1266 REMARK 465 GLY B 1267 REMARK 465 SER B 1268 REMARK 465 ALA B 1269 REMARK 465 TRP B 1270 REMARK 465 SER B 1271 REMARK 465 HIS B 1272 REMARK 465 PRO B 1273 REMARK 465 GLN B 1274 REMARK 465 PHE B 1275 REMARK 465 GLU B 1276 REMARK 465 LYS B 1277 REMARK 465 GLY B 1278 REMARK 465 GLY B 1279 REMARK 465 SER B 1280 REMARK 465 HIS B 1281 REMARK 465 HIS B 1282 REMARK 465 HIS B 1283 REMARK 465 HIS B 1284 REMARK 465 HIS B 1285 REMARK 465 HIS B 1286 REMARK 465 HIS B 1287 REMARK 465 HIS B 1288 REMARK 465 MET A -10 REMARK 465 PRO A -9 REMARK 465 MET A -8 REMARK 465 GLY A -7 REMARK 465 SER A -6 REMARK 465 LEU A -5 REMARK 465 GLN A -4 REMARK 465 PRO A -3 REMARK 465 LEU A -2 REMARK 465 ALA A -1 REMARK 465 THR A 0 REMARK 465 LEU A 1 REMARK 465 TYR A 2 REMARK 465 LEU A 3 REMARK 465 LEU A 4 REMARK 465 GLY A 5 REMARK 465 MET A 6 REMARK 465 LEU A 7 REMARK 465 VAL A 8 REMARK 465 ALA A 9 REMARK 465 SER A 10 REMARK 465 VAL A 11 REMARK 465 LEU A 12 REMARK 465 ALA A 13 REMARK 465 ILE A 68 REMARK 465 HIS A 69 REMARK 465 VAL A 70 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 76 REMARK 465 LYS A 77 REMARK 465 ARG A 78 REMARK 465 PHE A 79 REMARK 465 ASP A 80 REMARK 465 GLN A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 PHE A 175 REMARK 465 LEU A 176 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLU A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 PHE A 186 REMARK 465 LYS A 187 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 VAL A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 LYS A 679 REMARK 465 SER A 680 REMARK 465 HIS A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 SER A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 SER A 689 REMARK 465 THR A 827 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 LEU A 1145 REMARK 465 ASP A 1146 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 GLY A 1209 REMARK 465 SER A 1210 REMARK 465 GLY A 1211 REMARK 465 TYR A 1212 REMARK 465 ILE A 1213 REMARK 465 PRO A 1214 REMARK 465 GLU A 1215 REMARK 465 ALA A 1216 REMARK 465 PRO A 1217 REMARK 465 ARG A 1218 REMARK 465 ASP A 1219 REMARK 465 GLY A 1220 REMARK 465 GLN A 1221 REMARK 465 ALA A 1222 REMARK 465 TYR A 1223 REMARK 465 VAL A 1224 REMARK 465 ARG A 1225 REMARK 465 LYS A 1226 REMARK 465 ASP A 1227 REMARK 465 GLY A 1228 REMARK 465 GLU A 1229 REMARK 465 TRP A 1230 REMARK 465 VAL A 1231 REMARK 465 PHE A 1232 REMARK 465 LEU A 1233 REMARK 465 SER A 1234 REMARK 465 THR A 1235 REMARK 465 PHE A 1236 REMARK 465 LEU A 1237 REMARK 465 SER A 1238 REMARK 465 GLY A 1239 REMARK 465 LEU A 1240 REMARK 465 GLU A 1241 REMARK 465 VAL A 1242 REMARK 465 LEU A 1243 REMARK 465 PHE A 1244 REMARK 465 GLN A 1245 REMARK 465 GLY A 1246 REMARK 465 PRO A 1247 REMARK 465 GLY A 1248 REMARK 465 GLY A 1249 REMARK 465 TRP A 1250 REMARK 465 SER A 1251 REMARK 465 HIS A 1252 REMARK 465 PRO A 1253 REMARK 465 GLN A 1254 REMARK 465 PHE A 1255 REMARK 465 GLU A 1256 REMARK 465 LYS A 1257 REMARK 465 GLY A 1258 REMARK 465 GLY A 1259 REMARK 465 GLY A 1260 REMARK 465 SER A 1261 REMARK 465 GLY A 1262 REMARK 465 GLY A 1263 REMARK 465 GLY A 1264 REMARK 465 SER A 1265 REMARK 465 GLY A 1266 REMARK 465 GLY A 1267 REMARK 465 SER A 1268 REMARK 465 ALA A 1269 REMARK 465 TRP A 1270 REMARK 465 SER A 1271 REMARK 465 HIS A 1272 REMARK 465 PRO A 1273 REMARK 465 GLN A 1274 REMARK 465 PHE A 1275 REMARK 465 GLU A 1276 REMARK 465 LYS A 1277 REMARK 465 GLY A 1278 REMARK 465 GLY A 1279 REMARK 465 SER A 1280 REMARK 465 HIS A 1281 REMARK 465 HIS A 1282 REMARK 465 HIS A 1283 REMARK 465 HIS A 1284 REMARK 465 HIS A 1285 REMARK 465 HIS A 1286 REMARK 465 HIS A 1287 REMARK 465 HIS A 1288 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ARG H 31 -37.48 -130.99 REMARK 500 TYR H 37 -4.79 67.88 REMARK 500 ILE H 53 -61.20 -99.59 REMARK 500 SER H 113 -169.61 -168.49 REMARK 500 LYS H 132 -169.06 -79.04 REMARK 500 VAL L 53 -50.75 -121.41 REMARK 500 ASN L 57 -11.93 71.79 REMARK 500 ASN L 85 51.03 39.96 REMARK 500 TYR I 37 -2.28 67.99 REMARK 500 ILE I 53 -60.21 -108.94 REMARK 500 SER I 113 -164.66 -169.91 REMARK 500 ASN M 57 -13.19 72.04 REMARK 500 SER M 113 32.97 -98.34 REMARK 500 ASP M 172 -6.17 71.76 REMARK 500 ASN J 34 -30.09 -130.53 REMARK 500 TYR J 37 -3.42 68.25 REMARK 500 ILE J 53 -60.69 -106.67 REMARK 500 SER J 113 -166.34 -168.33 REMARK 500 THR J 114 69.16 60.52 REMARK 500 PRO J 164 76.82 -67.07 REMARK 500 ASN N 57 -9.78 71.94 REMARK 500 TYR N 65 -1.79 -141.32 REMARK 500 ASP N 172 -10.90 62.01 REMARK 500 SER N 173 -17.84 -142.46 REMARK 500 LEU C 18 -3.08 66.83 REMARK 500 LEU C 84 139.02 -39.99 REMARK 500 ASP C 88 24.31 -145.91 REMARK 500 LEU C 212 -13.23 70.54 REMARK 500 GLU C 213 58.96 35.16 REMARK 500 PRO C 330 -176.08 -69.55 REMARK 500 VAL C 341 -61.05 -97.75 REMARK 500 SER C 758 30.57 -97.34 REMARK 500 SER C 813 -5.32 69.04 REMARK 500 LEU C 945 33.96 -97.94 REMARK 500 LYS B 41 30.30 -96.32 REMARK 500 PHE B 135 -72.45 -63.63 REMARK 500 CYS B 136 -63.29 -125.67 REMARK 500 ASN B 137 -36.71 -134.46 REMARK 500 ARG B 158 34.29 -140.57 REMARK 500 ASN B 196 51.83 -119.74 REMARK 500 ILE B 210 -54.36 -125.02 REMARK 500 ASP B 215 -178.28 -66.15 REMARK 500 LEU B 229 71.46 52.31 REMARK 500 GLU B 309 33.41 -97.54 REMARK 500 TYR B 423 116.72 -160.12 REMARK 500 HIS B 519 -23.59 -140.60 REMARK 500 ILE B 666 -56.48 -123.55 REMARK 500 ALA B 783 36.40 -99.45 REMARK 500 TYR B 796 58.70 37.71 REMARK 500 SER B 813 -4.87 69.37 REMARK 500 REMARK 500 THIS ENTRY HAS 64 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-62729 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-62731 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-62733 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-62734 RELATED DB: EMDB REMARK 900 STRUCTURE OF SARS-COV-2 EG.5.1 VARIANT SPIKE PROTEIN COMPLEXED WITH REMARK 900 ANTIBODY XGI-203 REMARK 900 RELATED ID: 9L07 RELATED DB: PDB REMARK 900 RELATED ID: EMD-62691 RELATED DB: EMDB DBREF 9L15 H 1 458 PDB 9L15 9L15 1 458 DBREF 9L15 L 1 233 PDB 9L15 9L15 1 233 DBREF 9L15 I 1 458 PDB 9L15 9L15 1 458 DBREF 9L15 M 1 233 PDB 9L15 9L15 1 233 DBREF 9L15 J 1 458 PDB 9L15 9L15 1 458 DBREF 9L15 N 1 233 PDB 9L15 9L15 1 233 DBREF 9L15 C 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9L15 B 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9L15 A 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 SEQADV 9L15 MET C -10 UNP P0DTC2 INITIATING METHIONINE SEQADV 9L15 PRO C -9 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET C -8 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C -7 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C -6 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C -5 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN C -4 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO C -3 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA C -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 THR C 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR C 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET C 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL C 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA C 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL C 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA C 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ILE C 19 UNP P0DTC2 THR 19 VARIANT SEQADV 9L15 C UNP P0DTC2 LEU 24 DELETION SEQADV 9L15 C UNP P0DTC2 PRO 25 DELETION SEQADV 9L15 C UNP P0DTC2 PRO 26 DELETION SEQADV 9L15 SER C 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 9L15 HIS C 52 UNP P0DTC2 GLN 52 VARIANT SEQADV 9L15 ALA C 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 9L15 ASP C 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 9L15 C UNP P0DTC2 TYR 144 DELETION SEQADV 9L15 GLN C 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 9L15 GLU C 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 9L15 GLU C 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 9L15 VAL C 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 9L15 HIS C 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 9L15 THR C 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 9L15 ILE C 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 9L15 PHE C 371 UNP P0DTC2 SER 371 VARIANT SEQADV 9L15 PRO C 373 UNP P0DTC2 SER 373 VARIANT SEQADV 9L15 PHE C 375 UNP P0DTC2 SER 375 VARIANT SEQADV 9L15 ALA C 376 UNP P0DTC2 THR 376 VARIANT SEQADV 9L15 ASN C 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 9L15 SER C 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 9L15 ASN C 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 9L15 LYS C 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 9L15 PRO C 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 9L15 SER C 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 9L15 LEU C 456 UNP P0DTC2 PHE 456 VARIANT SEQADV 9L15 LYS C 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 9L15 ASN C 477 UNP P0DTC2 SER 477 VARIANT SEQADV 9L15 LYS C 478 UNP P0DTC2 THR 478 VARIANT SEQADV 9L15 ALA C 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 9L15 PRO C 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 9L15 SER C 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 9L15 ARG C 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 9L15 TYR C 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 9L15 HIS C 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 9L15 GLY C 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 9L15 TYR C 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 9L15 LYS C 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 9L15 HIS C 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 9L15 GLY C 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9L15 SER C 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9L15 SER C 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9L15 LYS C 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 9L15 TYR C 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 9L15 PRO C 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9L15 PRO C 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9L15 PRO C 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9L15 PRO C 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9L15 HIS C 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 9L15 LYS C 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 9L15 PRO C 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 9L15 PRO C 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 9L15 GLY C 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR C 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ILE C 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO C 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU C 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA C 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO C 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ARG C 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ASP C 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN C 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA C 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR C 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL C 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ARG C 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS C 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ASP C 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU C 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP C 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL C 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE C 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 THR C 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE C 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU C 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL C 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU C 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE C 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN C 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO C 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP C 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO C 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN C 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE C 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU C 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS C 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA C 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP C 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO C 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN C 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE C 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU C 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS C 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY C 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER C 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS C 1288 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET B -10 UNP P0DTC2 INITIATING METHIONINE SEQADV 9L15 PRO B -9 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET B -8 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B -7 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B -6 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B -5 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN B -4 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO B -3 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA B -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 THR B 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR B 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET B 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL B 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA B 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL B 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA B 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ILE B 19 UNP P0DTC2 THR 19 VARIANT SEQADV 9L15 B UNP P0DTC2 LEU 24 DELETION SEQADV 9L15 B UNP P0DTC2 PRO 25 DELETION SEQADV 9L15 B UNP P0DTC2 PRO 26 DELETION SEQADV 9L15 SER B 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 9L15 HIS B 52 UNP P0DTC2 GLN 52 VARIANT SEQADV 9L15 ALA B 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 9L15 ASP B 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 9L15 B UNP P0DTC2 TYR 144 DELETION SEQADV 9L15 GLN B 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 9L15 GLU B 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 9L15 GLU B 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 9L15 VAL B 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 9L15 HIS B 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 9L15 THR B 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 9L15 ILE B 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 9L15 PHE B 371 UNP P0DTC2 SER 371 VARIANT SEQADV 9L15 PRO B 373 UNP P0DTC2 SER 373 VARIANT SEQADV 9L15 PHE B 375 UNP P0DTC2 SER 375 VARIANT SEQADV 9L15 ALA B 376 UNP P0DTC2 THR 376 VARIANT SEQADV 9L15 ASN B 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 9L15 SER B 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 9L15 ASN B 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 9L15 LYS B 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 9L15 PRO B 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 9L15 SER B 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 9L15 LEU B 456 UNP P0DTC2 PHE 456 VARIANT SEQADV 9L15 LYS B 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 9L15 ASN B 477 UNP P0DTC2 SER 477 VARIANT SEQADV 9L15 LYS B 478 UNP P0DTC2 THR 478 VARIANT SEQADV 9L15 ALA B 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 9L15 PRO B 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 9L15 SER B 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 9L15 ARG B 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 9L15 TYR B 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 9L15 HIS B 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 9L15 GLY B 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 9L15 TYR B 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 9L15 LYS B 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 9L15 HIS B 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 9L15 GLY B 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9L15 SER B 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9L15 SER B 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9L15 LYS B 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 9L15 TYR B 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 9L15 PRO B 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9L15 PRO B 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9L15 PRO B 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9L15 PRO B 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9L15 HIS B 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 9L15 LYS B 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 9L15 PRO B 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 9L15 PRO B 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 9L15 GLY B 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR B 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ILE B 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO B 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU B 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA B 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO B 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ARG B 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ASP B 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN B 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA B 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR B 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL B 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ARG B 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS B 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ASP B 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU B 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP B 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL B 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE B 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 THR B 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE B 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU B 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL B 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU B 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE B 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN B 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO B 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP B 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO B 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN B 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE B 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU B 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS B 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA B 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP B 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO B 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN B 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE B 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU B 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS B 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY B 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER B 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS B 1288 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET A -10 UNP P0DTC2 INITIATING METHIONINE SEQADV 9L15 PRO A -9 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET A -8 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A -7 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A -6 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A -5 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN A -4 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO A -3 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A -2 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA A -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 THR A 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR A 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 MET A 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL A 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA A 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL A 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA A 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ILE A 19 UNP P0DTC2 THR 19 VARIANT SEQADV 9L15 A UNP P0DTC2 LEU 24 DELETION SEQADV 9L15 A UNP P0DTC2 PRO 25 DELETION SEQADV 9L15 A UNP P0DTC2 PRO 26 DELETION SEQADV 9L15 SER A 27 UNP P0DTC2 ALA 27 VARIANT SEQADV 9L15 HIS A 52 UNP P0DTC2 GLN 52 VARIANT SEQADV 9L15 ALA A 83 UNP P0DTC2 VAL 83 VARIANT SEQADV 9L15 ASP A 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 9L15 A UNP P0DTC2 TYR 144 DELETION SEQADV 9L15 GLN A 146 UNP P0DTC2 HIS 146 VARIANT SEQADV 9L15 GLU A 183 UNP P0DTC2 GLN 183 VARIANT SEQADV 9L15 GLU A 213 UNP P0DTC2 VAL 213 VARIANT SEQADV 9L15 VAL A 252 UNP P0DTC2 GLY 252 VARIANT SEQADV 9L15 HIS A 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 9L15 THR A 346 UNP P0DTC2 ARG 346 VARIANT SEQADV 9L15 ILE A 368 UNP P0DTC2 LEU 368 VARIANT SEQADV 9L15 PHE A 371 UNP P0DTC2 SER 371 VARIANT SEQADV 9L15 PRO A 373 UNP P0DTC2 SER 373 VARIANT SEQADV 9L15 PHE A 375 UNP P0DTC2 SER 375 VARIANT SEQADV 9L15 ALA A 376 UNP P0DTC2 THR 376 VARIANT SEQADV 9L15 ASN A 405 UNP P0DTC2 ASP 405 VARIANT SEQADV 9L15 SER A 408 UNP P0DTC2 ARG 408 VARIANT SEQADV 9L15 ASN A 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 9L15 LYS A 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 9L15 PRO A 445 UNP P0DTC2 VAL 445 VARIANT SEQADV 9L15 SER A 446 UNP P0DTC2 GLY 446 VARIANT SEQADV 9L15 LEU A 456 UNP P0DTC2 PHE 456 VARIANT SEQADV 9L15 LYS A 460 UNP P0DTC2 ASN 460 VARIANT SEQADV 9L15 ASN A 477 UNP P0DTC2 SER 477 VARIANT SEQADV 9L15 LYS A 478 UNP P0DTC2 THR 478 VARIANT SEQADV 9L15 ALA A 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 9L15 PRO A 486 UNP P0DTC2 PHE 486 VARIANT SEQADV 9L15 SER A 490 UNP P0DTC2 PHE 490 VARIANT SEQADV 9L15 ARG A 498 UNP P0DTC2 GLN 498 VARIANT SEQADV 9L15 TYR A 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 9L15 HIS A 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 9L15 GLY A 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 9L15 TYR A 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 9L15 LYS A 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 9L15 HIS A 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 9L15 GLY A 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9L15 SER A 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9L15 SER A 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9L15 LYS A 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 9L15 TYR A 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 9L15 PRO A 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9L15 PRO A 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9L15 PRO A 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9L15 PRO A 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9L15 HIS A 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 9L15 LYS A 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 9L15 PRO A 986 UNP P0DTC2 LYS 986 VARIANT SEQADV 9L15 PRO A 987 UNP P0DTC2 VAL 987 VARIANT SEQADV 9L15 GLY A 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR A 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ILE A 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ARG A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ASP A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TYR A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ARG A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ASP A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 THR A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 VAL A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LEU A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 ALA A 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 TRP A 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PRO A 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLN A 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 PHE A 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLU A 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 LYS A 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 GLY A 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 SER A 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 9L15 HIS A 1288 UNP P0DTC2 EXPRESSION TAG SEQRES 1 H 453 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL SER SEQRES 2 H 453 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 H 453 GLY SER ILE ARG ASN GLU VAL TYR TYR TRP SER TRP ILE SEQRES 4 H 453 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 H 453 ILE HIS TYR SER GLY ASN THR TYR TYR ASN PRO SER LEU SEQRES 6 H 453 LYS SER ARG VAL ALA ILE SER VAL ASP THR SER LYS ASN SEQRES 7 H 453 GLN PHE SER LEU LYS LEU ASN SER VAL THR ALA ALA ASP SEQRES 8 H 453 THR ALA VAL TYR TYR CYS ALA ARG VAL SER VAL GLY GLY SEQRES 9 H 453 ARG LEU VAL SER THR PHE ASP TYR TRP GLY GLN GLY THR SEQRES 10 H 453 LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SER SEQRES 11 H 453 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 H 453 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 H 453 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 H 453 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 H 453 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 H 453 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 H 453 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 H 453 GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO PRO SEQRES 19 H 453 CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL PHE SEQRES 20 H 453 LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SER SEQRES 21 H 453 ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SER SEQRES 22 H 453 HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL ASP SEQRES 23 H 453 GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG GLU SEQRES 24 H 453 GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL LEU SEQRES 25 H 453 THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU TYR SEQRES 26 H 453 LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO ILE SEQRES 27 H 453 GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG GLU SEQRES 28 H 453 PRO GLN VAL TYR THR LEU PRO PRO SER ARG GLU GLU MET SEQRES 29 H 453 THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS GLY SEQRES 30 H 453 PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER ASN SEQRES 31 H 453 GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO VAL SEQRES 32 H 453 LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS LEU SEQRES 33 H 453 THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL PHE SEQRES 34 H 453 SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS TYR SEQRES 35 H 453 THR GLN LYS SER LEU SER LEU SER PRO GLY LYS SEQRES 1 L 217 GLU PHE MET LEU THR GLN PRO HIS SER VAL SER GLU SER SEQRES 2 L 217 PRO GLU MET THR VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 L 217 GLY SER ILE ALA ASP ASN TYR VAL GLN TRP TYR GLN GLN SEQRES 4 L 217 ARG PRO GLY SER ALA PRO THR THR VAL ILE TYR GLU ASN SEQRES 5 L 217 TYR GLN ARG PRO SER GLY VAL PRO ASN ARG PHE SER GLY SEQRES 6 L 217 SER ILE ASP SER SER SER ASN SER ALA SER LEU THR ILE SEQRES 7 L 217 SER GLY LEU LYS THR GLU ASP GLU ALA ASP TYR TYR CYS SEQRES 8 L 217 GLN SER TYR ASP ASN SER ASN VAL ALA VAL PHE GLY GLY SEQRES 9 L 217 GLY THR GLN LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 L 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 L 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 L 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 L 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 L 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 L 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 L 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 L 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 I 453 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL SER SEQRES 2 I 453 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 I 453 GLY SER ILE ARG ASN GLU VAL TYR TYR TRP SER TRP ILE SEQRES 4 I 453 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 I 453 ILE HIS TYR SER GLY ASN THR TYR TYR ASN PRO SER LEU SEQRES 6 I 453 LYS SER ARG VAL ALA ILE SER VAL ASP THR SER LYS ASN SEQRES 7 I 453 GLN PHE SER LEU LYS LEU ASN SER VAL THR ALA ALA ASP SEQRES 8 I 453 THR ALA VAL TYR TYR CYS ALA ARG VAL SER VAL GLY GLY SEQRES 9 I 453 ARG LEU VAL SER THR PHE ASP TYR TRP GLY GLN GLY THR SEQRES 10 I 453 LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SER SEQRES 11 I 453 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 I 453 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 I 453 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 I 453 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 I 453 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 I 453 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 I 453 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 I 453 GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO PRO SEQRES 19 I 453 CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL PHE SEQRES 20 I 453 LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SER SEQRES 21 I 453 ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SER SEQRES 22 I 453 HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL ASP SEQRES 23 I 453 GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG GLU SEQRES 24 I 453 GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL LEU SEQRES 25 I 453 THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU TYR SEQRES 26 I 453 LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO ILE SEQRES 27 I 453 GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG GLU SEQRES 28 I 453 PRO GLN VAL TYR THR LEU PRO PRO SER ARG GLU GLU MET SEQRES 29 I 453 THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS GLY SEQRES 30 I 453 PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER ASN SEQRES 31 I 453 GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO VAL SEQRES 32 I 453 LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS LEU SEQRES 33 I 453 THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL PHE SEQRES 34 I 453 SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS TYR SEQRES 35 I 453 THR GLN LYS SER LEU SER LEU SER PRO GLY LYS SEQRES 1 M 217 GLU PHE MET LEU THR GLN PRO HIS SER VAL SER GLU SER SEQRES 2 M 217 PRO GLU MET THR VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 M 217 GLY SER ILE ALA ASP ASN TYR VAL GLN TRP TYR GLN GLN SEQRES 4 M 217 ARG PRO GLY SER ALA PRO THR THR VAL ILE TYR GLU ASN SEQRES 5 M 217 TYR GLN ARG PRO SER GLY VAL PRO ASN ARG PHE SER GLY SEQRES 6 M 217 SER ILE ASP SER SER SER ASN SER ALA SER LEU THR ILE SEQRES 7 M 217 SER GLY LEU LYS THR GLU ASP GLU ALA ASP TYR TYR CYS SEQRES 8 M 217 GLN SER TYR ASP ASN SER ASN VAL ALA VAL PHE GLY GLY SEQRES 9 M 217 GLY THR GLN LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 M 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 M 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 M 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 M 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 M 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 M 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 M 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 M 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 J 453 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL SER SEQRES 2 J 453 PRO SER GLN THR LEU SER LEU THR CYS THR VAL SER GLY SEQRES 3 J 453 GLY SER ILE ARG ASN GLU VAL TYR TYR TRP SER TRP ILE SEQRES 4 J 453 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY TYR SEQRES 5 J 453 ILE HIS TYR SER GLY ASN THR TYR TYR ASN PRO SER LEU SEQRES 6 J 453 LYS SER ARG VAL ALA ILE SER VAL ASP THR SER LYS ASN SEQRES 7 J 453 GLN PHE SER LEU LYS LEU ASN SER VAL THR ALA ALA ASP SEQRES 8 J 453 THR ALA VAL TYR TYR CYS ALA ARG VAL SER VAL GLY GLY SEQRES 9 J 453 ARG LEU VAL SER THR PHE ASP TYR TRP GLY GLN GLY THR SEQRES 10 J 453 LEU VAL THR VAL ALA SER ALA SER THR LYS GLY PRO SER SEQRES 11 J 453 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 J 453 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 J 453 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 J 453 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 J 453 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 J 453 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 J 453 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 J 453 GLU PRO LYS SER CYS ASP LYS THR HIS THR CYS PRO PRO SEQRES 19 J 453 CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL PHE SEQRES 20 J 453 LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SER SEQRES 21 J 453 ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SER SEQRES 22 J 453 HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL ASP SEQRES 23 J 453 GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG GLU SEQRES 24 J 453 GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL LEU SEQRES 25 J 453 THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU TYR SEQRES 26 J 453 LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO ILE SEQRES 27 J 453 GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG GLU SEQRES 28 J 453 PRO GLN VAL TYR THR LEU PRO PRO SER ARG GLU GLU MET SEQRES 29 J 453 THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS GLY SEQRES 30 J 453 PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER ASN SEQRES 31 J 453 GLY GLN PRO GLU ASN ASN TYR LYS THR THR PRO PRO VAL SEQRES 32 J 453 LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS LEU SEQRES 33 J 453 THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL PHE SEQRES 34 J 453 SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS TYR SEQRES 35 J 453 THR GLN LYS SER LEU SER LEU SER PRO GLY LYS SEQRES 1 N 217 GLU PHE MET LEU THR GLN PRO HIS SER VAL SER GLU SER SEQRES 2 N 217 PRO GLU MET THR VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 N 217 GLY SER ILE ALA ASP ASN TYR VAL GLN TRP TYR GLN GLN SEQRES 4 N 217 ARG PRO GLY SER ALA PRO THR THR VAL ILE TYR GLU ASN SEQRES 5 N 217 TYR GLN ARG PRO SER GLY VAL PRO ASN ARG PHE SER GLY SEQRES 6 N 217 SER ILE ASP SER SER SER ASN SER ALA SER LEU THR ILE SEQRES 7 N 217 SER GLY LEU LYS THR GLU ASP GLU ALA ASP TYR TYR CYS SEQRES 8 N 217 GLN SER TYR ASP ASN SER ASN VAL ALA VAL PHE GLY GLY SEQRES 9 N 217 GLY THR GLN LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 N 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 N 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 N 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 N 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 N 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 N 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 N 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 N 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 C 1295 MET PRO MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR SEQRES 2 C 1295 LEU LEU GLY MET LEU VAL ALA SER VAL LEU ALA GLN CYS SEQRES 3 C 1295 VAL ASN LEU ILE THR ARG THR GLN SER TYR THR ASN SER SEQRES 4 C 1295 PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SEQRES 5 C 1295 SER SER VAL LEU HIS SER THR HIS ASP LEU PHE LEU PRO SEQRES 6 C 1295 PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SEQRES 7 C 1295 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO ALA SEQRES 8 C 1295 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 9 C 1295 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 10 C 1295 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 11 C 1295 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 12 C 1295 CYS ASN ASP PRO PHE LEU ASP VAL TYR GLN LYS ASN ASN SEQRES 13 C 1295 LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SER SEQRES 14 C 1295 ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO PHE SEQRES 15 C 1295 LEU MET ASP LEU GLU GLY LYS GLU GLY ASN PHE LYS ASN SEQRES 16 C 1295 LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE SEQRES 17 C 1295 LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU GLU ARG SEQRES 18 C 1295 ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU VAL SEQRES 19 C 1295 ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN THR SEQRES 20 C 1295 LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO VAL ASP SEQRES 21 C 1295 SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR TYR SEQRES 22 C 1295 VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS TYR SEQRES 23 C 1295 ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS ALA SEQRES 24 C 1295 LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SER SEQRES 25 C 1295 PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN PHE SEQRES 26 C 1295 ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO ASN SEQRES 27 C 1295 ILE THR ASN LEU CYS PRO PHE HIS GLU VAL PHE ASN ALA SEQRES 28 C 1295 THR THR PHE ALA SER VAL TYR ALA TRP ASN ARG LYS ARG SEQRES 29 C 1295 ILE SER ASN CYS VAL ALA ASP TYR SER VAL ILE TYR ASN SEQRES 30 C 1295 PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SER SEQRES 31 C 1295 PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL TYR SEQRES 32 C 1295 ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER GLN SEQRES 33 C 1295 ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR ASN SEQRES 34 C 1295 TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE ALA SEQRES 35 C 1295 TRP ASN SER ASN LYS LEU ASP SER LYS PRO SER GLY ASN SEQRES 36 C 1295 TYR ASN TYR LEU TYR ARG LEU LEU ARG LYS SER LYS LEU SEQRES 37 C 1295 LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR GLN SEQRES 38 C 1295 ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY PRO ASN SEQRES 39 C 1295 CYS TYR SER PRO LEU GLN SER TYR GLY PHE ARG PRO THR SEQRES 40 C 1295 TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL LEU SEQRES 41 C 1295 SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS GLY SEQRES 42 C 1295 PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS VAL SEQRES 43 C 1295 ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL LEU SEQRES 44 C 1295 THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE SEQRES 45 C 1295 GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG ASP SEQRES 46 C 1295 PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SER SEQRES 47 C 1295 PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN THR SEQRES 48 C 1295 SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS SEQRES 49 C 1295 THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU THR SEQRES 50 C 1295 PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL PHE SEQRES 51 C 1295 GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR VAL SEQRES 52 C 1295 ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY SEQRES 53 C 1295 ILE CYS ALA SER TYR GLN THR GLN THR LYS SER HIS GLY SEQRES 54 C 1295 SER ALA SER SER VAL ALA SER GLN SER ILE ILE ALA TYR SEQRES 55 C 1295 THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SER SEQRES 56 C 1295 ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SER SEQRES 57 C 1295 VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS THR SEQRES 58 C 1295 SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER THR SEQRES 59 C 1295 GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE CYS SEQRES 60 C 1295 THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL GLU SEQRES 61 C 1295 GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL LYS SEQRES 62 C 1295 GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY GLY SEQRES 63 C 1295 PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS PRO SEQRES 64 C 1295 SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN LYS SEQRES 65 C 1295 VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY SEQRES 66 C 1295 ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS SEQRES 67 C 1295 ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO LEU SEQRES 68 C 1295 LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA LEU SEQRES 69 C 1295 LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY ALA SEQRES 70 C 1295 GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET ALA SEQRES 71 C 1295 TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL LEU SEQRES 72 C 1295 TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SER SEQRES 73 C 1295 ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR PRO SEQRES 74 C 1295 SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS ASN SEQRES 75 C 1295 ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SER SEQRES 76 C 1295 LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE LEU SEQRES 77 C 1295 SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP SEQRES 78 C 1295 ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR TYR SEQRES 79 C 1295 VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SEQRES 80 C 1295 SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS VAL SEQRES 81 C 1295 LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS GLY SEQRES 82 C 1295 TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS GLY SEQRES 83 C 1295 VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN GLU SEQRES 84 C 1295 LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP GLY SEQRES 85 C 1295 LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER ASN SEQRES 86 C 1295 GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR GLU SEQRES 87 C 1295 PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER GLY SEQRES 88 C 1295 ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR VAL SEQRES 89 C 1295 TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS GLU SEQRES 90 C 1295 GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO ASP SEQRES 91 C 1295 VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER VAL SEQRES 92 C 1295 VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL SEQRES 93 C 1295 ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN GLU SEQRES 94 C 1295 LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO GLU SEQRES 95 C 1295 ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY SEQRES 96 C 1295 GLU TRP VAL PHE LEU SER THR PHE LEU SER GLY LEU GLU SEQRES 97 C 1295 VAL LEU PHE GLN GLY PRO GLY GLY TRP SER HIS PRO GLN SEQRES 98 C 1295 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY SEQRES 99 C 1295 SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SER SEQRES 100 C 1295 HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 B 1295 MET PRO MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR SEQRES 2 B 1295 LEU LEU GLY MET LEU VAL ALA SER VAL LEU ALA GLN CYS SEQRES 3 B 1295 VAL ASN LEU ILE THR ARG THR GLN SER TYR THR ASN SER SEQRES 4 B 1295 PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SEQRES 5 B 1295 SER SER VAL LEU HIS SER THR HIS ASP LEU PHE LEU PRO SEQRES 6 B 1295 PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SEQRES 7 B 1295 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO ALA SEQRES 8 B 1295 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 9 B 1295 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 10 B 1295 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 11 B 1295 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 12 B 1295 CYS ASN ASP PRO PHE LEU ASP VAL TYR GLN LYS ASN ASN SEQRES 13 B 1295 LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SER SEQRES 14 B 1295 ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO PHE SEQRES 15 B 1295 LEU MET ASP LEU GLU GLY LYS GLU GLY ASN PHE LYS ASN SEQRES 16 B 1295 LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE SEQRES 17 B 1295 LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU GLU ARG SEQRES 18 B 1295 ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU VAL SEQRES 19 B 1295 ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN THR SEQRES 20 B 1295 LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO VAL ASP SEQRES 21 B 1295 SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR TYR SEQRES 22 B 1295 VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS TYR SEQRES 23 B 1295 ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS ALA SEQRES 24 B 1295 LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SER SEQRES 25 B 1295 PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN PHE SEQRES 26 B 1295 ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO ASN SEQRES 27 B 1295 ILE THR ASN LEU CYS PRO PHE HIS GLU VAL PHE ASN ALA SEQRES 28 B 1295 THR THR PHE ALA SER VAL TYR ALA TRP ASN ARG LYS ARG SEQRES 29 B 1295 ILE SER ASN CYS VAL ALA ASP TYR SER VAL ILE TYR ASN SEQRES 30 B 1295 PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SER SEQRES 31 B 1295 PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL TYR SEQRES 32 B 1295 ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER GLN SEQRES 33 B 1295 ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR ASN SEQRES 34 B 1295 TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE ALA SEQRES 35 B 1295 TRP ASN SER ASN LYS LEU ASP SER LYS PRO SER GLY ASN SEQRES 36 B 1295 TYR ASN TYR LEU TYR ARG LEU LEU ARG LYS SER LYS LEU SEQRES 37 B 1295 LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR GLN SEQRES 38 B 1295 ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY PRO ASN SEQRES 39 B 1295 CYS TYR SER PRO LEU GLN SER TYR GLY PHE ARG PRO THR SEQRES 40 B 1295 TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL LEU SEQRES 41 B 1295 SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS GLY SEQRES 42 B 1295 PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS VAL SEQRES 43 B 1295 ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL LEU SEQRES 44 B 1295 THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE SEQRES 45 B 1295 GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG ASP SEQRES 46 B 1295 PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SER SEQRES 47 B 1295 PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN THR SEQRES 48 B 1295 SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS SEQRES 49 B 1295 THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU THR SEQRES 50 B 1295 PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL PHE SEQRES 51 B 1295 GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR VAL SEQRES 52 B 1295 ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY SEQRES 53 B 1295 ILE CYS ALA SER TYR GLN THR GLN THR LYS SER HIS GLY SEQRES 54 B 1295 SER ALA SER SER VAL ALA SER GLN SER ILE ILE ALA TYR SEQRES 55 B 1295 THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SER SEQRES 56 B 1295 ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SER SEQRES 57 B 1295 VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS THR SEQRES 58 B 1295 SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER THR SEQRES 59 B 1295 GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE CYS SEQRES 60 B 1295 THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL GLU SEQRES 61 B 1295 GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL LYS SEQRES 62 B 1295 GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY GLY SEQRES 63 B 1295 PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS PRO SEQRES 64 B 1295 SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN LYS SEQRES 65 B 1295 VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY SEQRES 66 B 1295 ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS SEQRES 67 B 1295 ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO LEU SEQRES 68 B 1295 LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA LEU SEQRES 69 B 1295 LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY ALA SEQRES 70 B 1295 GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET ALA SEQRES 71 B 1295 TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL LEU SEQRES 72 B 1295 TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SER SEQRES 73 B 1295 ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR PRO SEQRES 74 B 1295 SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS ASN SEQRES 75 B 1295 ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SER SEQRES 76 B 1295 LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE LEU SEQRES 77 B 1295 SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP SEQRES 78 B 1295 ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR TYR SEQRES 79 B 1295 VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SEQRES 80 B 1295 SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS VAL SEQRES 81 B 1295 LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS GLY SEQRES 82 B 1295 TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS GLY SEQRES 83 B 1295 VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN GLU SEQRES 84 B 1295 LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP GLY SEQRES 85 B 1295 LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER ASN SEQRES 86 B 1295 GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR GLU SEQRES 87 B 1295 PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER GLY SEQRES 88 B 1295 ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR VAL SEQRES 89 B 1295 TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS GLU SEQRES 90 B 1295 GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO ASP SEQRES 91 B 1295 VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER VAL SEQRES 92 B 1295 VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL SEQRES 93 B 1295 ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN GLU SEQRES 94 B 1295 LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO GLU SEQRES 95 B 1295 ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY SEQRES 96 B 1295 GLU TRP VAL PHE LEU SER THR PHE LEU SER GLY LEU GLU SEQRES 97 B 1295 VAL LEU PHE GLN GLY PRO GLY GLY TRP SER HIS PRO GLN SEQRES 98 B 1295 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY SEQRES 99 B 1295 SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SER SEQRES 100 B 1295 HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 A 1295 MET PRO MET GLY SER LEU GLN PRO LEU ALA THR LEU TYR SEQRES 2 A 1295 LEU LEU GLY MET LEU VAL ALA SER VAL LEU ALA GLN CYS SEQRES 3 A 1295 VAL ASN LEU ILE THR ARG THR GLN SER TYR THR ASN SER SEQRES 4 A 1295 PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SEQRES 5 A 1295 SER SER VAL LEU HIS SER THR HIS ASP LEU PHE LEU PRO SEQRES 6 A 1295 PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE HIS VAL SEQRES 7 A 1295 SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN PRO ALA SEQRES 8 A 1295 LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER THR GLU SEQRES 9 A 1295 LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY THR THR SEQRES 10 A 1295 LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL ASN ASN SEQRES 11 A 1295 ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE GLN PHE SEQRES 12 A 1295 CYS ASN ASP PRO PHE LEU ASP VAL TYR GLN LYS ASN ASN SEQRES 13 A 1295 LYS SER TRP MET GLU SER GLU PHE ARG VAL TYR SER SER SEQRES 14 A 1295 ALA ASN ASN CYS THR PHE GLU TYR VAL SER GLN PRO PHE SEQRES 15 A 1295 LEU MET ASP LEU GLU GLY LYS GLU GLY ASN PHE LYS ASN SEQRES 16 A 1295 LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP GLY TYR PHE SEQRES 17 A 1295 LYS ILE TYR SER LYS HIS THR PRO ILE ASN LEU GLU ARG SEQRES 18 A 1295 ASP LEU PRO GLN GLY PHE SER ALA LEU GLU PRO LEU VAL SEQRES 19 A 1295 ASP LEU PRO ILE GLY ILE ASN ILE THR ARG PHE GLN THR SEQRES 20 A 1295 LEU LEU ALA LEU HIS ARG SER TYR LEU THR PRO VAL ASP SEQRES 21 A 1295 SER SER SER GLY TRP THR ALA GLY ALA ALA ALA TYR TYR SEQRES 22 A 1295 VAL GLY TYR LEU GLN PRO ARG THR PHE LEU LEU LYS TYR SEQRES 23 A 1295 ASN GLU ASN GLY THR ILE THR ASP ALA VAL ASP CYS ALA SEQRES 24 A 1295 LEU ASP PRO LEU SER GLU THR LYS CYS THR LEU LYS SER SEQRES 25 A 1295 PHE THR VAL GLU LYS GLY ILE TYR GLN THR SER ASN PHE SEQRES 26 A 1295 ARG VAL GLN PRO THR GLU SER ILE VAL ARG PHE PRO ASN SEQRES 27 A 1295 ILE THR ASN LEU CYS PRO PHE HIS GLU VAL PHE ASN ALA SEQRES 28 A 1295 THR THR PHE ALA SER VAL TYR ALA TRP ASN ARG LYS ARG SEQRES 29 A 1295 ILE SER ASN CYS VAL ALA ASP TYR SER VAL ILE TYR ASN SEQRES 30 A 1295 PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR GLY VAL SER SEQRES 31 A 1295 PRO THR LYS LEU ASN ASP LEU CYS PHE THR ASN VAL TYR SEQRES 32 A 1295 ALA ASP SER PHE VAL ILE ARG GLY ASN GLU VAL SER GLN SEQRES 33 A 1295 ILE ALA PRO GLY GLN THR GLY ASN ILE ALA ASP TYR ASN SEQRES 34 A 1295 TYR LYS LEU PRO ASP ASP PHE THR GLY CYS VAL ILE ALA SEQRES 35 A 1295 TRP ASN SER ASN LYS LEU ASP SER LYS PRO SER GLY ASN SEQRES 36 A 1295 TYR ASN TYR LEU TYR ARG LEU LEU ARG LYS SER LYS LEU SEQRES 37 A 1295 LYS PRO PHE GLU ARG ASP ILE SER THR GLU ILE TYR GLN SEQRES 38 A 1295 ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA GLY PRO ASN SEQRES 39 A 1295 CYS TYR SER PRO LEU GLN SER TYR GLY PHE ARG PRO THR SEQRES 40 A 1295 TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL VAL VAL LEU SEQRES 41 A 1295 SER PHE GLU LEU LEU HIS ALA PRO ALA THR VAL CYS GLY SEQRES 42 A 1295 PRO LYS LYS SER THR ASN LEU VAL LYS ASN LYS CYS VAL SEQRES 43 A 1295 ASN PHE ASN PHE ASN GLY LEU THR GLY THR GLY VAL LEU SEQRES 44 A 1295 THR GLU SER ASN LYS LYS PHE LEU PRO PHE GLN GLN PHE SEQRES 45 A 1295 GLY ARG ASP ILE ALA ASP THR THR ASP ALA VAL ARG ASP SEQRES 46 A 1295 PRO GLN THR LEU GLU ILE LEU ASP ILE THR PRO CYS SER SEQRES 47 A 1295 PHE GLY GLY VAL SER VAL ILE THR PRO GLY THR ASN THR SEQRES 48 A 1295 SER ASN GLN VAL ALA VAL LEU TYR GLN GLY VAL ASN CYS SEQRES 49 A 1295 THR GLU VAL PRO VAL ALA ILE HIS ALA ASP GLN LEU THR SEQRES 50 A 1295 PRO THR TRP ARG VAL TYR SER THR GLY SER ASN VAL PHE SEQRES 51 A 1295 GLN THR ARG ALA GLY CYS LEU ILE GLY ALA GLU TYR VAL SEQRES 52 A 1295 ASN ASN SER TYR GLU CYS ASP ILE PRO ILE GLY ALA GLY SEQRES 53 A 1295 ILE CYS ALA SER TYR GLN THR GLN THR LYS SER HIS GLY SEQRES 54 A 1295 SER ALA SER SER VAL ALA SER GLN SER ILE ILE ALA TYR SEQRES 55 A 1295 THR MET SER LEU GLY ALA GLU ASN SER VAL ALA TYR SER SEQRES 56 A 1295 ASN ASN SER ILE ALA ILE PRO THR ASN PHE THR ILE SER SEQRES 57 A 1295 VAL THR THR GLU ILE LEU PRO VAL SER MET THR LYS THR SEQRES 58 A 1295 SER VAL ASP CYS THR MET TYR ILE CYS GLY ASP SER THR SEQRES 59 A 1295 GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SER PHE CYS SEQRES 60 A 1295 THR GLN LEU LYS ARG ALA LEU THR GLY ILE ALA VAL GLU SEQRES 61 A 1295 GLN ASP LYS ASN THR GLN GLU VAL PHE ALA GLN VAL LYS SEQRES 62 A 1295 GLN ILE TYR LYS THR PRO PRO ILE LYS TYR PHE GLY GLY SEQRES 63 A 1295 PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SER LYS PRO SEQRES 64 A 1295 SER LYS ARG SER PRO ILE GLU ASP LEU LEU PHE ASN LYS SEQRES 65 A 1295 VAL THR LEU ALA ASP ALA GLY PHE ILE LYS GLN TYR GLY SEQRES 66 A 1295 ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP LEU ILE CYS SEQRES 67 A 1295 ALA GLN LYS PHE ASN GLY LEU THR VAL LEU PRO PRO LEU SEQRES 68 A 1295 LEU THR ASP GLU MET ILE ALA GLN TYR THR SER ALA LEU SEQRES 69 A 1295 LEU ALA GLY THR ILE THR SER GLY TRP THR PHE GLY ALA SEQRES 70 A 1295 GLY PRO ALA LEU GLN ILE PRO PHE PRO MET GLN MET ALA SEQRES 71 A 1295 TYR ARG PHE ASN GLY ILE GLY VAL THR GLN ASN VAL LEU SEQRES 72 A 1295 TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN PHE ASN SER SEQRES 73 A 1295 ALA ILE GLY LYS ILE GLN ASP SER LEU SER SER THR PRO SEQRES 74 A 1295 SER ALA LEU GLY LYS LEU GLN ASP VAL VAL ASN HIS ASN SEQRES 75 A 1295 ALA GLN ALA LEU ASN THR LEU VAL LYS GLN LEU SER SER SEQRES 76 A 1295 LYS PHE GLY ALA ILE SER SER VAL LEU ASN ASP ILE LEU SEQRES 77 A 1295 SER ARG LEU ASP PRO PRO GLU ALA GLU VAL GLN ILE ASP SEQRES 78 A 1295 ARG LEU ILE THR GLY ARG LEU GLN SER LEU GLN THR TYR SEQRES 79 A 1295 VAL THR GLN GLN LEU ILE ARG ALA ALA GLU ILE ARG ALA SEQRES 80 A 1295 SER ALA ASN LEU ALA ALA THR LYS MET SER GLU CYS VAL SEQRES 81 A 1295 LEU GLY GLN SER LYS ARG VAL ASP PHE CYS GLY LYS GLY SEQRES 82 A 1295 TYR HIS LEU MET SER PHE PRO GLN SER ALA PRO HIS GLY SEQRES 83 A 1295 VAL VAL PHE LEU HIS VAL THR TYR VAL PRO ALA GLN GLU SEQRES 84 A 1295 LYS ASN PHE THR THR ALA PRO ALA ILE CYS HIS ASP GLY SEQRES 85 A 1295 LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE VAL SER ASN SEQRES 86 A 1295 GLY THR HIS TRP PHE VAL THR GLN ARG ASN PHE TYR GLU SEQRES 87 A 1295 PRO GLN ILE ILE THR THR ASP ASN THR PHE VAL SER GLY SEQRES 88 A 1295 ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN ASN THR VAL SEQRES 89 A 1295 TYR ASP PRO LEU GLN PRO GLU LEU ASP SER PHE LYS GLU SEQRES 90 A 1295 GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SER PRO ASP SEQRES 91 A 1295 VAL ASP LEU GLY ASP ILE SER GLY ILE ASN ALA SER VAL SEQRES 92 A 1295 VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU ASN GLU VAL SEQRES 93 A 1295 ALA LYS ASN LEU ASN GLU SER LEU ILE ASP LEU GLN GLU SEQRES 94 A 1295 LEU GLY LYS TYR GLU GLN GLY SER GLY TYR ILE PRO GLU SEQRES 95 A 1295 ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY SEQRES 96 A 1295 GLU TRP VAL PHE LEU SER THR PHE LEU SER GLY LEU GLU SEQRES 97 A 1295 VAL LEU PHE GLN GLY PRO GLY GLY TRP SER HIS PRO GLN SEQRES 98 A 1295 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY SEQRES 99 A 1295 SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SER SEQRES 100 A 1295 HIS HIS HIS HIS HIS HIS HIS HIS HET NAG D 1 14 HET NAG D 2 14 HET NAG E 1 14 HET NAG E 2 14 HET NAG F 1 14 HET NAG F 2 14 HET BMA F 3 11 HET NAG G 1 14 HET NAG G 2 14 HET NAG K 1 14 HET NAG K 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG X 1 14 HET NAG X 2 14 HET NAG Y 1 14 HET NAG Y 2 14 HET NAG Z 1 14 HET NAG Z 2 14 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET NAG c 1 14 HET NAG c 2 14 HET NAG d 1 14 HET NAG d 2 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG A1307 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 61(C8 H15 N O6) FORMUL 12 BMA C6 H12 O6 HELIX 1 AA1 ASN H 68 LYS H 72 5 5 HELIX 2 AA2 THR H 95 THR H 99 5 5 HELIX 3 AA3 SER H 202 GLY H 205 5 4 HELIX 4 AA4 LYS L 95 GLU L 99 5 5 HELIX 5 AA5 SER L 142 ALA L 148 1 7 HELIX 6 AA6 THR L 202 SER L 208 1 7 HELIX 7 AA7 ASN I 68 LYS I 72 5 5 HELIX 8 AA8 THR I 95 THR I 99 5 5 HELIX 9 AA9 TRP I 169 ALA I 173 5 5 HELIX 10 AB1 SER I 202 GLY I 205 5 4 HELIX 11 AB2 SER M 29 ASN M 37 5 5 HELIX 12 AB3 LYS M 95 GLU M 99 5 5 HELIX 13 AB4 SER M 142 GLN M 147 1 6 HELIX 14 AB5 THR M 202 SER M 208 1 7 HELIX 15 AB6 PRO J 69 LYS J 72 5 4 HELIX 16 AB7 THR J 95 THR J 99 5 5 HELIX 17 AB8 SER J 171 ALA J 173 5 3 HELIX 18 AB9 SER J 202 GLY J 205 5 4 HELIX 19 AC1 SER N 29 ASN N 37 5 5 HELIX 20 AC2 LYS N 95 GLU N 99 5 5 HELIX 21 AC3 SER N 142 GLN N 147 1 6 HELIX 22 AC4 THR N 202 SER N 208 1 7 HELIX 23 AC5 ASP C 294 LYS C 304 1 11 HELIX 24 AC6 PHE C 338 ASN C 343 1 6 HELIX 25 AC7 TYR C 365 ALA C 372 1 8 HELIX 26 AC8 GLY C 416 ASN C 422 1 7 HELIX 27 AC9 SER C 438 SER C 443 1 6 HELIX 28 AD1 ASN C 616 VAL C 620 5 5 HELIX 29 AD2 ASP C 737 CYS C 743 1 7 HELIX 30 AD3 SER C 746 GLY C 757 1 12 HELIX 31 AD4 SER C 758 ALA C 783 1 26 HELIX 32 AD5 LYS C 811 ARG C 815 5 5 HELIX 33 AD6 SER C 816 VAL C 826 1 11 HELIX 34 AD7 THR C 866 SER C 884 1 19 HELIX 35 AD8 TRP C 886 GLY C 891 1 6 HELIX 36 AD9 PRO C 897 ILE C 909 1 13 HELIX 37 AE1 GLN C 913 THR C 941 1 29 HELIX 38 AE2 LEU C 945 GLN C 965 1 21 HELIX 39 AE3 LEU C 966 SER C 968 5 3 HELIX 40 AE4 VAL C 976 SER C 982 1 7 HELIX 41 AE5 ASP C 985 VAL C 1033 1 49 HELIX 42 AE6 ASP B 294 LEU B 303 1 10 HELIX 43 AE7 PRO B 337 ASN B 343 1 7 HELIX 44 AE8 ASP B 364 PHE B 371 5 8 HELIX 45 AE9 ASN B 405 ILE B 410 5 6 HELIX 46 AF1 GLY B 416 ASN B 422 1 7 HELIX 47 AF2 GLY B 502 HIS B 505 5 4 HELIX 48 AF3 ASN B 616 VAL B 620 5 5 HELIX 49 AF4 ASP B 737 CYS B 743 1 7 HELIX 50 AF5 GLU B 748 LEU B 754 1 7 HELIX 51 AF6 GLN B 755 GLY B 757 5 3 HELIX 52 AF7 SER B 758 ALA B 783 1 26 HELIX 53 AF8 LYS B 811 ARG B 815 5 5 HELIX 54 AF9 SER B 816 VAL B 826 1 11 HELIX 55 AG1 THR B 866 SER B 884 1 19 HELIX 56 AG2 TRP B 886 GLY B 891 1 6 HELIX 57 AG3 PRO B 897 ILE B 909 1 13 HELIX 58 AG4 THR B 912 ASN B 919 1 8 HELIX 59 AG5 ASN B 919 THR B 941 1 23 HELIX 60 AG6 PRO B 942 ALA B 944 5 3 HELIX 61 AG7 LEU B 945 GLN B 965 1 21 HELIX 62 AG8 LEU B 966 SER B 968 5 3 HELIX 63 AG9 VAL B 976 LEU B 981 1 6 HELIX 64 AH1 ASP B 985 VAL B 1033 1 49 HELIX 65 AH2 ASP A 294 LEU A 303 1 10 HELIX 66 AH3 PRO A 337 ASN A 343 1 7 HELIX 67 AH4 ASP A 364 PHE A 371 5 8 HELIX 68 AH5 LYS A 386 ASP A 389 5 4 HELIX 69 AH6 ASN A 405 VAL A 407 5 3 HELIX 70 AH7 GLY A 416 ASN A 422 1 7 HELIX 71 AH8 ASP A 737 CYS A 743 1 7 HELIX 72 AH9 SER A 746 LEU A 754 1 9 HELIX 73 AI1 GLN A 755 GLY A 757 5 3 HELIX 74 AI2 SER A 758 ALA A 783 1 26 HELIX 75 AI3 SER A 816 LYS A 825 1 10 HELIX 76 AI4 THR A 866 SER A 884 1 19 HELIX 77 AI5 TRP A 886 GLY A 891 1 6 HELIX 78 AI6 PRO A 897 ILE A 909 1 13 HELIX 79 AI7 THR A 912 GLU A 918 1 7 HELIX 80 AI8 ASN A 919 SER A 940 1 22 HELIX 81 AI9 THR A 941 ALA A 944 5 4 HELIX 82 AJ1 LEU A 945 GLN A 965 1 21 HELIX 83 AJ2 VAL A 976 LEU A 984 1 9 HELIX 84 AJ3 ASP A 985 VAL A 1033 1 49 SHEET 1 AA1 4 LEU H 4 SER H 7 0 SHEET 2 AA1 4 LEU H 19 VAL H 25 -1 O THR H 24 N GLN H 5 SHEET 3 AA1 4 GLN H 86 LEU H 91 -1 O LEU H 91 N LEU H 19 SHEET 4 AA1 4 VAL H 76 ASP H 81 -1 N ALA H 77 O LYS H 90 SHEET 1 AA2 5 LEU H 12 VAL H 13 0 SHEET 2 AA2 5 THR H 122 VAL H 126 1 O THR H 125 N VAL H 13 SHEET 3 AA2 5 ALA H 100 ARG H 106 -1 N TYR H 102 O THR H 122 SHEET 4 AA2 5 TYR H 38 GLN H 44 -1 N ILE H 42 O TYR H 103 SHEET 5 AA2 5 GLU H 51 HIS H 57 -1 O GLU H 51 N ARG H 43 SHEET 1 AA3 4 SER H 135 LEU H 139 0 SHEET 2 AA3 4 THR H 150 TYR H 160 -1 O LEU H 156 N PHE H 137 SHEET 3 AA3 4 TYR H 191 PRO H 200 -1 O VAL H 199 N ALA H 151 SHEET 4 AA3 4 VAL H 178 THR H 180 -1 N HIS H 179 O VAL H 196 SHEET 1 AA4 4 SER H 135 LEU H 139 0 SHEET 2 AA4 4 THR H 150 TYR H 160 -1 O LEU H 156 N PHE H 137 SHEET 3 AA4 4 TYR H 191 PRO H 200 -1 O VAL H 199 N ALA H 151 SHEET 4 AA4 4 VAL H 184 LEU H 185 -1 N VAL H 184 O SER H 192 SHEET 1 AA5 3 SER H 168 TRP H 169 0 SHEET 2 AA5 3 CYS H 211 ASN H 214 -1 O ASN H 212 N SER H 168 SHEET 3 AA5 3 LYS H 221 LYS H 224 -1 O LYS H 224 N CYS H 211 SHEET 1 AA6 5 SER L 9 GLU L 13 0 SHEET 2 AA6 5 THR L 122 VAL L 126 1 O THR L 125 N VAL L 11 SHEET 3 AA6 5 ASP L 101 ASP L 108 -1 N TYR L 102 O THR L 122 SHEET 4 AA6 5 GLN L 40 GLN L 44 -1 N GLN L 40 O GLN L 105 SHEET 5 AA6 5 THR L 51 ILE L 54 -1 O THR L 51 N GLN L 43 SHEET 1 AA7 4 SER L 9 GLU L 13 0 SHEET 2 AA7 4 THR L 122 VAL L 126 1 O THR L 125 N VAL L 11 SHEET 3 AA7 4 ASP L 101 ASP L 108 -1 N TYR L 102 O THR L 122 SHEET 4 AA7 4 VAL L 115 PHE L 118 -1 O VAL L 115 N ASP L 108 SHEET 1 AA8 3 THR L 18 THR L 24 0 SHEET 2 AA8 3 SER L 86 SER L 92 -1 O LEU L 89 N ILE L 21 SHEET 3 AA8 3 PHE L 76 ASP L 81 -1 N SER L 77 O THR L 90 SHEET 1 AA9 4 THR L 137 PHE L 139 0 SHEET 2 AA9 4 ALA L 151 SER L 158 -1 O LEU L 156 N THR L 137 SHEET 3 AA9 4 TYR L 193 LEU L 201 -1 O ALA L 195 N ILE L 157 SHEET 4 AA9 4 GLY L 179 THR L 182 -1 N GLU L 181 O TYR L 198 SHEET 1 AB1 4 THR L 137 PHE L 139 0 SHEET 2 AB1 4 ALA L 151 SER L 158 -1 O LEU L 156 N THR L 137 SHEET 3 AB1 4 TYR L 193 LEU L 201 -1 O ALA L 195 N ILE L 157 SHEET 4 AB1 4 SER L 186 LYS L 187 -1 N SER L 186 O ALA L 194 SHEET 1 AB2 3 THR L 166 LYS L 170 0 SHEET 2 AB2 3 SER L 213 HIS L 218 -1 O SER L 213 N LYS L 170 SHEET 3 AB2 3 SER L 221 GLU L 224 -1 O SER L 221 N HIS L 218 SHEET 1 AB3 4 GLN I 3 SER I 7 0 SHEET 2 AB3 4 LEU I 19 SER I 26 -1 O THR I 22 N SER I 7 SHEET 3 AB3 4 GLN I 86 LEU I 91 -1 O LEU I 91 N LEU I 19 SHEET 4 AB3 4 VAL I 76 ASP I 81 -1 N ALA I 77 O LYS I 90 SHEET 1 AB4 4 GLU I 51 ILE I 56 0 SHEET 2 AB4 4 TYR I 37 GLN I 44 -1 N ARG I 43 O GLU I 51 SHEET 3 AB4 4 VAL I 101 SER I 108 -1 O TYR I 103 N ILE I 42 SHEET 4 AB4 4 THR I 122 LEU I 123 -1 O THR I 122 N TYR I 102 SHEET 1 AB5 4 SER I 135 LEU I 139 0 SHEET 2 AB5 4 THR I 150 TYR I 160 -1 O LEU I 156 N PHE I 137 SHEET 3 AB5 4 TYR I 191 PRO I 200 -1 O VAL I 199 N ALA I 151 SHEET 4 AB5 4 VAL I 178 THR I 180 -1 N HIS I 179 O VAL I 196 SHEET 1 AB6 4 SER I 135 LEU I 139 0 SHEET 2 AB6 4 THR I 150 TYR I 160 -1 O LEU I 156 N PHE I 137 SHEET 3 AB6 4 TYR I 191 PRO I 200 -1 O VAL I 199 N ALA I 151 SHEET 4 AB6 4 VAL I 184 LEU I 185 -1 N VAL I 184 O SER I 192 SHEET 1 AB7 4 LEU M 4 THR M 5 0 SHEET 2 AB7 4 THR M 18 GLY M 25 -1 O THR M 24 N THR M 5 SHEET 3 AB7 4 SER M 86 SER M 92 -1 O ILE M 91 N VAL M 19 SHEET 4 AB7 4 PHE M 76 ASP M 81 -1 N ASP M 81 O SER M 86 SHEET 1 AB8 5 SER M 9 GLU M 13 0 SHEET 2 AB8 5 THR M 122 VAL M 126 1 O GLN M 123 N VAL M 11 SHEET 3 AB8 5 ASP M 101 TYR M 107 -1 N TYR M 102 O THR M 122 SHEET 4 AB8 5 GLN M 40 GLN M 44 -1 N GLN M 40 O GLN M 105 SHEET 5 AB8 5 THR M 51 ILE M 54 -1 O VAL M 53 N TRP M 41 SHEET 1 AB9 4 SER M 9 GLU M 13 0 SHEET 2 AB9 4 THR M 122 VAL M 126 1 O GLN M 123 N VAL M 11 SHEET 3 AB9 4 ASP M 101 TYR M 107 -1 N TYR M 102 O THR M 122 SHEET 4 AB9 4 ALA M 116 PHE M 118 -1 O VAL M 117 N SER M 106 SHEET 1 AC1 4 THR M 137 PHE M 139 0 SHEET 2 AC1 4 ALA M 151 PHE M 160 -1 O LEU M 156 N THR M 137 SHEET 3 AC1 4 TYR M 193 LEU M 201 -1 O LEU M 199 N LEU M 153 SHEET 4 AC1 4 GLY M 179 THR M 182 -1 N GLU M 181 O TYR M 198 SHEET 1 AC2 4 THR M 137 PHE M 139 0 SHEET 2 AC2 4 ALA M 151 PHE M 160 -1 O LEU M 156 N THR M 137 SHEET 3 AC2 4 TYR M 193 LEU M 201 -1 O LEU M 199 N LEU M 153 SHEET 4 AC2 4 SER M 186 LYS M 187 -1 N SER M 186 O ALA M 194 SHEET 1 AC3 3 VAL M 167 LYS M 170 0 SHEET 2 AC3 3 SER M 213 HIS M 218 -1 O SER M 213 N LYS M 170 SHEET 3 AC3 3 SER M 221 VAL M 223 -1 O SER M 221 N HIS M 218 SHEET 1 AC4 4 GLN J 3 SER J 7 0 SHEET 2 AC4 4 LEU J 19 SER J 26 -1 O THR J 22 N SER J 7 SHEET 3 AC4 4 GLN J 86 LEU J 91 -1 O LEU J 91 N LEU J 19 SHEET 4 AC4 4 VAL J 76 ASP J 81 -1 N ALA J 77 O LYS J 90 SHEET 1 AC5 5 THR J 65 TYR J 67 0 SHEET 2 AC5 5 GLU J 51 ILE J 56 -1 N TYR J 55 O TYR J 66 SHEET 3 AC5 5 TRP J 39 GLN J 44 -1 N TRP J 41 O ILE J 53 SHEET 4 AC5 5 ALA J 100 ARG J 106 -1 O VAL J 101 N GLN J 44 SHEET 5 AC5 5 THR J 122 VAL J 124 -1 O THR J 122 N TYR J 102 SHEET 1 AC6 4 SER J 135 PRO J 138 0 SHEET 2 AC6 4 THR J 150 TYR J 160 -1 O LEU J 156 N PHE J 137 SHEET 3 AC6 4 TYR J 191 PRO J 200 -1 O LEU J 193 N VAL J 157 SHEET 4 AC6 4 VAL J 178 THR J 180 -1 N HIS J 179 O VAL J 196 SHEET 1 AC7 4 SER J 135 PRO J 138 0 SHEET 2 AC7 4 THR J 150 TYR J 160 -1 O LEU J 156 N PHE J 137 SHEET 3 AC7 4 TYR J 191 PRO J 200 -1 O LEU J 193 N VAL J 157 SHEET 4 AC7 4 VAL J 184 LEU J 185 -1 N VAL J 184 O SER J 192 SHEET 1 AC8 3 VAL J 165 TRP J 169 0 SHEET 2 AC8 3 CYS J 211 HIS J 215 -1 O ASN J 212 N SER J 168 SHEET 3 AC8 3 THR J 220 LYS J 224 -1 O THR J 220 N HIS J 215 SHEET 1 AC9 4 LEU N 4 THR N 5 0 SHEET 2 AC9 4 VAL N 19 GLY N 25 -1 O THR N 24 N THR N 5 SHEET 3 AC9 4 SER N 86 ILE N 91 -1 O ALA N 87 N CYS N 23 SHEET 4 AC9 4 PHE N 76 ASP N 81 -1 N SER N 77 O THR N 90 SHEET 1 AD1 5 SER N 9 GLU N 13 0 SHEET 2 AD1 5 THR N 122 VAL N 126 1 O THR N 125 N VAL N 11 SHEET 3 AD1 5 ASP N 101 TYR N 107 -1 N TYR N 102 O THR N 122 SHEET 4 AD1 5 GLN N 40 GLN N 44 -1 N GLN N 40 O GLN N 105 SHEET 5 AD1 5 THR N 51 ILE N 54 -1 O THR N 51 N GLN N 43 SHEET 1 AD2 4 SER N 9 GLU N 13 0 SHEET 2 AD2 4 THR N 122 VAL N 126 1 O THR N 125 N VAL N 11 SHEET 3 AD2 4 ASP N 101 TYR N 107 -1 N TYR N 102 O THR N 122 SHEET 4 AD2 4 ALA N 116 PHE N 118 -1 O VAL N 117 N SER N 106 SHEET 1 AD3 4 SER N 135 PHE N 139 0 SHEET 2 AD3 4 ALA N 151 SER N 158 -1 O LEU N 156 N THR N 137 SHEET 3 AD3 4 TYR N 193 LEU N 201 -1 O ALA N 195 N ILE N 157 SHEET 4 AD3 4 VAL N 180 THR N 182 -1 N GLU N 181 O TYR N 198 SHEET 1 AD4 4 SER N 135 PHE N 139 0 SHEET 2 AD4 4 ALA N 151 SER N 158 -1 O LEU N 156 N THR N 137 SHEET 3 AD4 4 TYR N 193 LEU N 201 -1 O ALA N 195 N ILE N 157 SHEET 4 AD4 4 SER N 186 LYS N 187 -1 N SER N 186 O ALA N 194 SHEET 1 AD5 3 THR N 166 LYS N 170 0 SHEET 2 AD5 3 SER N 213 HIS N 218 -1 O GLN N 215 N ALA N 168 SHEET 3 AD5 3 SER N 221 VAL N 223 -1 O SER N 221 N HIS N 218 SHEET 1 AD6 7 ARG C 21 THR C 29 0 SHEET 2 AD6 7 VAL C 62 ALA C 67 -1 O VAL C 62 N THR C 29 SHEET 3 AD6 7 TYR C 265 TYR C 269 -1 O TYR C 265 N PHE C 65 SHEET 4 AD6 7 VAL C 90 SER C 94 -1 N ALA C 93 O TYR C 266 SHEET 5 AD6 7 LEU C 189 ILE C 197 -1 O PHE C 192 N PHE C 92 SHEET 6 AD6 7 TYR C 200 THR C 208 -1 O THR C 208 N LEU C 189 SHEET 7 AD6 7 GLU C 224 LEU C 229 -1 O LEU C 226 N ILE C 203 SHEET 1 AD7 7 VAL C 42 PHE C 43 0 SHEET 2 AD7 7 PHE A 565 ARG A 567 1 O PHE A 565 N PHE C 43 SHEET 3 AD7 7 THR A 573 ARG A 577 -1 O ALA A 575 N GLY A 566 SHEET 4 AD7 7 ILE A 584 THR A 588 -1 O ILE A 587 N ASP A 574 SHEET 5 AD7 7 THR A 547 GLU A 554 -1 N VAL A 551 O THR A 588 SHEET 6 AD7 7 CYS A 538 ASN A 542 -1 N PHE A 541 O GLY A 548 SHEET 7 AD7 7 SER A 325 VAL A 327 1 N ILE A 326 O ASN A 540 SHEET 1 AD8 3 LEU C 48 PHE C 55 0 SHEET 2 AD8 3 GLN C 271 TYR C 279 -1 O PHE C 275 N THR C 51 SHEET 3 AD8 3 ILE C 285 ASP C 287 -1 O ASP C 287 N LYS C 278 SHEET 1 AD9 5 CYS C 166 TYR C 170 0 SHEET 2 AD9 5 VAL C 127 CYS C 131 -1 N VAL C 130 O THR C 167 SHEET 3 AD9 5 SER C 116 VAL C 120 -1 N LEU C 118 O LYS C 129 SHEET 4 AD9 5 ILE C 101 GLY C 107 -1 N PHE C 106 O LEU C 117 SHEET 5 AD9 5 ARG C 237 LEU C 242 -1 O ARG C 237 N GLY C 107 SHEET 1 AE1 5 GLY C 311 ARG C 319 0 SHEET 2 AE1 5 PHE C 592 THR C 599 -1 O VAL C 595 N SER C 316 SHEET 3 AE1 5 ALA C 609 GLN C 613 -1 O ALA C 609 N ILE C 598 SHEET 4 AE1 5 GLY C 648 ILE C 651 -1 O ILE C 651 N VAL C 610 SHEET 5 AE1 5 PHE C 643 THR C 645 -1 N PHE C 643 O LEU C 650 SHEET 1 AE2 5 ASN C 354 ILE C 358 0 SHEET 2 AE2 5 VAL C 395 ILE C 402 -1 O ALA C 397 N LYS C 356 SHEET 3 AE2 5 TYR C 508 PHE C 515 -1 O TYR C 508 N ILE C 402 SHEET 4 AE2 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AE2 5 ALA C 376 TYR C 380 -1 N LYS C 378 O VAL C 433 SHEET 1 AE3 2 CYS C 391 PHE C 392 0 SHEET 2 AE3 2 VAL C 524 CYS C 525 -1 O VAL C 524 N PHE C 392 SHEET 1 AE4 2 LEU C 452 ARG C 454 0 SHEET 2 AE4 2 LEU C 492 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AE5 2 TYR C 473 GLN C 474 0 SHEET 2 AE5 2 CYS C 488 TYR C 489 -1 O TYR C 489 N TYR C 473 SHEET 1 AE6 6 CYS C 538 PHE C 543 0 SHEET 2 AE6 6 LEU C 546 GLU C 554 -1 O GLY C 548 N PHE C 541 SHEET 3 AE6 6 ILE C 584 THR C 588 -1 O ASP C 586 N THR C 553 SHEET 4 AE6 6 THR C 573 ARG C 577 -1 N VAL C 576 O LEU C 585 SHEET 5 AE6 6 PHE C 565 ARG C 567 -1 N GLY C 566 O ALA C 575 SHEET 6 AE6 6 VAL B 42 PHE B 43 1 O PHE B 43 N ARG C 567 SHEET 1 AE7 4 GLU C 654 TYR C 655 0 SHEET 2 AE7 4 SER C 691 THR C 696 1 O ALA C 694 N GLU C 654 SHEET 3 AE7 4 ILE C 670 GLN C 675 -1 N SER C 673 O ILE C 693 SHEET 4 AE7 4 ILE C 664 GLY C 667 -1 N GLY C 667 O ILE C 670 SHEET 1 AE8 2 GLU C 702 SER C 704 0 SHEET 2 AE8 2 ILE B 788 LYS B 790 1 O LYS B 790 N ASN C 703 SHEET 1 AE9 3 SER C 711 PRO C 728 0 SHEET 2 AE9 3 GLY C1059 THR C1077 -1 O VAL C1068 N THR C 719 SHEET 3 AE9 3 TYR C1047 ALA C1056 -1 N TYR C1047 O TYR C1067 SHEET 1 AF1 5 SER C 711 PRO C 728 0 SHEET 2 AF1 5 GLY C1059 THR C1077 -1 O VAL C1068 N THR C 719 SHEET 3 AF1 5 VAL C1094 SER C1097 -1 O SER C1097 N THR C1076 SHEET 4 AF1 5 TRP C1102 THR C1105 -1 O THR C1105 N VAL C1094 SHEET 5 AF1 5 GLN C1113 ILE C1114 -1 O GLN C1113 N VAL C1104 SHEET 1 AF2 2 LYS C 733 VAL C 736 0 SHEET 2 AF2 2 LEU C 858 LEU C 861 -1 O LEU C 861 N LYS C 733 SHEET 1 AF3 2 GLN C 787 TYR C 789 0 SHEET 2 AF3 2 ALA A 701 ASN A 703 1 O ASN A 703 N ILE C 788 SHEET 1 AF4 4 THR C1120 ASN C1125 0 SHEET 2 AF4 4 LYS C1086 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AF4 4 ILE C1081 HIS C1083 -1 N HIS C1083 O LYS C1086 SHEET 4 AF4 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AF5 7 GLN B 23 TYR B 28 0 SHEET 2 AF5 7 THR B 63 HIS B 66 -1 O TRP B 64 N SER B 27 SHEET 3 AF5 7 ALA B 264 TYR B 269 -1 O TYR B 265 N PHE B 65 SHEET 4 AF5 7 GLY B 89 SER B 94 -1 N ALA B 93 O TYR B 266 SHEET 5 AF5 7 LEU B 189 ILE B 197 -1 O PHE B 192 N PHE B 92 SHEET 6 AF5 7 TYR B 200 THR B 208 -1 O THR B 208 N LEU B 189 SHEET 7 AF5 7 GLU B 224 VAL B 227 -1 O LEU B 226 N ILE B 203 SHEET 1 AF6 3 LEU B 48 THR B 51 0 SHEET 2 AF6 3 PHE B 275 TYR B 279 -1 O LEU B 277 N HIS B 49 SHEET 3 AF6 3 ILE B 285 ASP B 290 -1 O VAL B 289 N LEU B 276 SHEET 1 AF7 2 LEU B 54 PHE B 55 0 SHEET 2 AF7 2 GLN B 271 PRO B 272 -1 O GLN B 271 N PHE B 55 SHEET 1 AF8 6 LEU B 141 ASP B 142 0 SHEET 2 AF8 6 ARG B 237 LEU B 244 1 O LEU B 242 N LEU B 141 SHEET 3 AF8 6 ILE B 101 GLY B 107 -1 N GLY B 107 O ARG B 237 SHEET 4 AF8 6 SER B 116 ASN B 121 -1 O LEU B 117 N PHE B 106 SHEET 5 AF8 6 VAL B 126 CYS B 131 -1 O VAL B 127 N VAL B 120 SHEET 6 AF8 6 GLU B 169 TYR B 170 -1 O TYR B 170 N ILE B 128 SHEET 1 AF9 5 ILE B 312 ARG B 319 0 SHEET 2 AF9 5 PHE B 592 ILE B 598 -1 O GLY B 593 N PHE B 318 SHEET 3 AF9 5 ALA B 609 GLN B 613 -1 O ALA B 609 N ILE B 598 SHEET 4 AF9 5 GLY B 648 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AF9 5 VAL B 642 THR B 645 -1 N PHE B 643 O LEU B 650 SHEET 1 AG1 5 ASN B 354 ILE B 358 0 SHEET 2 AG1 5 VAL B 395 ARG B 403 -1 O ALA B 397 N LYS B 356 SHEET 3 AG1 5 PRO B 507 SER B 514 -1 O VAL B 512 N ASP B 398 SHEET 4 AG1 5 GLY B 431 ASN B 437 -1 N ILE B 434 O VAL B 511 SHEET 5 AG1 5 ALA B 376 TYR B 380 -1 N TYR B 380 O GLY B 431 SHEET 1 AG2 2 LEU B 452 ARG B 454 0 SHEET 2 AG2 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AG3 2 TYR B 473 GLN B 474 0 SHEET 2 AG3 2 CYS B 488 TYR B 489 -1 O TYR B 489 N TYR B 473 SHEET 1 AG4 6 CYS B 538 PHE B 543 0 SHEET 2 AG4 6 LEU B 546 GLU B 554 -1 O GLY B 548 N PHE B 541 SHEET 3 AG4 6 ILE B 584 THR B 588 -1 O ASP B 586 N THR B 553 SHEET 4 AG4 6 THR B 573 ARG B 577 -1 N ASP B 574 O ILE B 587 SHEET 5 AG4 6 PHE B 565 ARG B 567 -1 N GLY B 566 O ALA B 575 SHEET 6 AG4 6 VAL A 42 PHE A 43 1 O PHE A 43 N PHE B 565 SHEET 1 AG5 4 GLU B 654 TYR B 655 0 SHEET 2 AG5 4 SER B 691 THR B 696 1 O ALA B 694 N GLU B 654 SHEET 3 AG5 4 ILE B 670 GLN B 675 -1 N CYS B 671 O TYR B 695 SHEET 4 AG5 4 ILE B 664 PRO B 665 -1 N ILE B 664 O ALA B 672 SHEET 1 AG6 2 ALA B 701 SER B 704 0 SHEET 2 AG6 2 GLN A 787 LYS A 790 1 O LYS A 790 N ASN B 703 SHEET 1 AG7 3 SER B 711 PRO B 728 0 SHEET 2 AG7 3 GLY B1059 THR B1077 -1 O VAL B1068 N THR B 719 SHEET 3 AG7 3 TYR B1047 ALA B1056 -1 N TYR B1047 O TYR B1067 SHEET 1 AG8 4 SER B 711 PRO B 728 0 SHEET 2 AG8 4 GLY B1059 THR B1077 -1 O VAL B1068 N THR B 719 SHEET 3 AG8 4 VAL B1094 SER B1097 -1 O SER B1097 N THR B1076 SHEET 4 AG8 4 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 1 AG9 2 LYS B 733 VAL B 736 0 SHEET 2 AG9 2 LEU B 858 LEU B 861 -1 O THR B 859 N SER B 735 SHEET 1 AH1 4 THR B1120 ASN B1125 0 SHEET 2 AH1 4 LYS B1086 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AH1 4 ILE B1081 CYS B1082 -1 N ILE B1081 O HIS B1088 SHEET 4 AH1 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AH2 3 LEU A 48 PHE A 55 0 SHEET 2 AH2 3 GLN A 271 TYR A 279 -1 O LEU A 277 N HIS A 49 SHEET 3 AH2 3 ILE A 285 ASP A 290 -1 O THR A 286 N LYS A 278 SHEET 1 AH3 2 LEU A 84 PRO A 85 0 SHEET 2 AH3 2 ARG A 237 PHE A 238 -1 O PHE A 238 N LEU A 84 SHEET 1 AH4 5 GLU A 224 LEU A 229 0 SHEET 2 AH4 5 TYR A 200 THR A 208 -1 N ILE A 203 O LEU A 226 SHEET 3 AH4 5 LEU A 189 ILE A 197 -1 N LEU A 189 O THR A 208 SHEET 4 AH4 5 GLY A 89 PHE A 92 -1 N PHE A 92 O PHE A 192 SHEET 5 AH4 5 VAL A 267 TYR A 269 -1 O GLY A 268 N TYR A 91 SHEET 1 AH5 2 GLY A 103 TRP A 104 0 SHEET 2 AH5 2 ILE A 119 VAL A 120 -1 O ILE A 119 N TRP A 104 SHEET 1 AH6 2 VAL A 126 VAL A 127 0 SHEET 2 AH6 2 VAL A 171 SER A 172 -1 O SER A 172 N VAL A 126 SHEET 1 AH7 2 LEU A 141 ASP A 142 0 SHEET 2 AH7 2 ALA A 243 LEU A 244 1 O LEU A 244 N LEU A 141 SHEET 1 AH8 5 GLY A 311 ARG A 319 0 SHEET 2 AH8 5 PHE A 592 THR A 599 -1 O GLY A 593 N PHE A 318 SHEET 3 AH8 5 ALA A 609 GLN A 613 -1 O ALA A 609 N ILE A 598 SHEET 4 AH8 5 GLY A 648 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 5 AH8 5 PHE A 643 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AH9 5 ASN A 354 ILE A 358 0 SHEET 2 AH9 5 ASN A 394 ARG A 403 -1 O VAL A 395 N ILE A 358 SHEET 3 AH9 5 PRO A 507 GLU A 516 -1 O VAL A 510 N PHE A 400 SHEET 4 AH9 5 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 5 AH9 5 ALA A 376 TYR A 380 -1 N TYR A 380 O GLY A 431 SHEET 1 AI1 2 CYS A 391 PHE A 392 0 SHEET 2 AI1 2 VAL A 524 CYS A 525 -1 O VAL A 524 N PHE A 392 SHEET 1 AI2 2 LEU A 452 ARG A 454 0 SHEET 2 AI2 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AI3 2 TYR A 473 GLN A 474 0 SHEET 2 AI3 2 CYS A 488 TYR A 489 -1 O TYR A 489 N TYR A 473 SHEET 1 AI4 4 GLU A 654 TYR A 660 0 SHEET 2 AI4 4 SER A 691 MET A 697 1 O ALA A 694 N VAL A 656 SHEET 3 AI4 4 ILE A 670 GLN A 675 -1 N CYS A 671 O TYR A 695 SHEET 4 AI4 4 ILE A 664 GLY A 667 -1 N GLY A 667 O ILE A 670 SHEET 1 AI5 3 SER A 711 PRO A 728 0 SHEET 2 AI5 3 GLY A1059 THR A1077 -1 O VAL A1068 N THR A 719 SHEET 3 AI5 3 TYR A1047 ALA A1056 -1 N MET A1050 O VAL A1065 SHEET 1 AI6 4 SER A 711 PRO A 728 0 SHEET 2 AI6 4 GLY A1059 THR A1077 -1 O VAL A1068 N THR A 719 SHEET 3 AI6 4 VAL A1094 SER A1097 -1 O SER A1097 N THR A1076 SHEET 4 AI6 4 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 1 AI7 2 LYS A 733 VAL A 736 0 SHEET 2 AI7 2 LEU A 858 LEU A 861 -1 O THR A 859 N SER A 735 SHEET 1 AI8 4 THR A1120 VAL A1122 0 SHEET 2 AI8 4 ALA A1087 PRO A1090 -1 N PHE A1089 O PHE A1121 SHEET 3 AI8 4 ILE A1081 CYS A1082 -1 N ILE A1081 O HIS A1088 SHEET 4 AI8 4 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SSBOND 1 CYS H 23 CYS H 104 1555 1555 2.03 SSBOND 2 CYS H 155 CYS H 211 1555 1555 2.03 SSBOND 3 CYS L 23 CYS L 104 1555 1555 2.03 SSBOND 4 CYS L 155 CYS L 214 1555 1555 2.03 SSBOND 5 CYS I 23 CYS I 104 1555 1555 2.03 SSBOND 6 CYS I 155 CYS I 211 1555 1555 2.03 SSBOND 7 CYS M 23 CYS M 104 1555 1555 2.03 SSBOND 8 CYS M 155 CYS M 214 1555 1555 2.03 SSBOND 9 CYS J 23 CYS J 104 1555 1555 2.03 SSBOND 10 CYS J 155 CYS J 211 1555 1555 2.03 SSBOND 11 CYS N 23 CYS N 104 1555 1555 2.03 SSBOND 12 CYS N 155 CYS N 214 1555 1555 2.03 SSBOND 13 CYS C 15 CYS C 136 1555 1555 2.03 SSBOND 14 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 15 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 16 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 17 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 18 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 19 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 20 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 21 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 22 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 23 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 24 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 25 CYS C 1032 CYS C 1043 1555 1555 2.03 SSBOND 26 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 27 CYS B 15 CYS B 136 1555 1555 2.03 SSBOND 28 CYS B 131 CYS B 166 1555 1555 2.03 SSBOND 29 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 30 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 31 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 32 CYS B 391 CYS B 525 1555 1555 2.03 SSBOND 33 CYS B 480 CYS B 488 1555 1555 2.03 SSBOND 34 CYS B 538 CYS B 590 1555 1555 2.03 SSBOND 35 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 36 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 37 CYS B 738 CYS B 760 1555 1555 2.03 SSBOND 38 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 39 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 40 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 41 CYS A 15 CYS A 136 1555 1555 2.04 SSBOND 42 CYS A 131 CYS A 166 1555 1555 2.03 SSBOND 43 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 44 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 45 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 46 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 47 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 48 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 49 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 50 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 51 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 52 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 53 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 54 CYS A 1082 CYS A 1126 1555 1555 2.03 LINK ND2 ASN C 61 C1 NAG D 1 1555 1555 1.45 LINK ND2 ASN C 125 C1 NAG C1304 1555 1555 1.44 LINK ND2 ASN C 165 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C 234 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN C 282 C1 NAG C1301 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG F 1 1555 1555 1.45 LINK ND2 ASN C 616 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C 709 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 717 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN C1074 C1 NAG C1306 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN B 61 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN B 122 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN B 165 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN B 234 C1 NAG B1304 1555 1555 1.44 LINK ND2 ASN B 282 C1 NAG B1305 1555 1555 1.44 LINK ND2 ASN B 331 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN B 343 C1 NAG B1306 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1301 1555 1555 1.44 LINK ND2 ASN B 709 C1 NAG B1302 1555 1555 1.44 LINK ND2 ASN B 717 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN B1074 C1 NAG B1303 1555 1555 1.44 LINK ND2 ASN B1098 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG T 1 1555 1555 1.45 LINK ND2 ASN A 122 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN A 165 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 282 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 343 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1305 1555 1555 1.44 LINK ND2 ASN A 709 C1 NAG A1306 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN A1074 C1 NAG A1307 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN A1134 C1 NAG d 1 1555 1555 1.44 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.44 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.44 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG F 2 C1 BMA F 3 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.45 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.45 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.45 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.44 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.44 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000